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Search of human proteins with 14719833
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14719833 NLR family, pyrin domain containing 1 isoform 3
[Homo sapiens]
(1443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 2941 0.0
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 2925 0.0
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 2829 0.0
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 2813 0.0
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 2682 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 488 e-137
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 461 e-129
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 461 e-129
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 461 e-129
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 440 e-123
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 434 e-121
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 423 e-118
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 343 9e-94
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 337 6e-92
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 327 7e-89
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 327 7e-89
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 323 6e-88
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 322 2e-87
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 316 1e-85
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 316 1e-85
gi|7662404 caspase recruitment domain family, member 8 [Homo sap... 303 1e-81
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 296 7e-80
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 281 3e-75
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 252 2e-66
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 250 8e-66
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 144 5e-34
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 130 7e-30
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 130 7e-30
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 130 7e-30
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 130 7e-30
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 2941 bits (7624), Expect = 0.0
Identities = 1443/1443 (100%), Positives = 1443/1443 (100%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
Query: 961 VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE
Sbjct: 961 VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
Query: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW
Sbjct: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
Query: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV
Sbjct: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
Query: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP
Sbjct: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
Query: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRY 1260
VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRY
Sbjct: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRY 1260
Query: 1261 TVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1320
TVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV
Sbjct: 1261 TVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1320
Query: 1321 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1380
KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ
Sbjct: 1321 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1380
Query: 1381 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1440
EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP
Sbjct: 1381 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1440
Query: 1441 LSS 1443
LSS
Sbjct: 1441 LSS 1443
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 2925 bits (7583), Expect = 0.0
Identities = 1443/1473 (97%), Positives = 1443/1473 (97%), Gaps = 30/1473 (2%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 958 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 991 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050
ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
Query: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110
GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
Query: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170
PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
Query: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230
ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
Query: 1231 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1290
KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
Sbjct: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320
Query: 1291 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1350
SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380
Query: 1351 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1410
FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440
Query: 1411 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1443
KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 2829 bits (7334), Expect = 0.0
Identities = 1399/1443 (96%), Positives = 1399/1443 (96%), Gaps = 44/1443 (3%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
Query: 961 VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE
Sbjct: 961 VMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPE 1020
Query: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW
Sbjct: 1021 VVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRW 1080
Query: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV
Sbjct: 1081 PNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFV 1140
Query: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP
Sbjct: 1141 ALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIP 1200
Query: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRY 1260
VTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 VTSVVLLYHRVHPEEVTFHLYLIPSDCSIR------------------------------ 1230
Query: 1261 TVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1320
KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV
Sbjct: 1231 --------------KELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALV 1276
Query: 1321 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1380
KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ
Sbjct: 1277 KPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQ 1336
Query: 1381 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1440
EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP
Sbjct: 1337 EQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLP 1396
Query: 1441 LSS 1443
LSS
Sbjct: 1397 LSS 1399
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 2813 bits (7293), Expect = 0.0
Identities = 1399/1473 (94%), Positives = 1399/1473 (94%), Gaps = 74/1473 (5%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 958 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 991 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050
ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
Query: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110
GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
Query: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170
PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
Query: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230
ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
Query: 1231 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1290
KELELCYRSPGEDQLF
Sbjct: 1261 --------------------------------------------KELELCYRSPGEDQLF 1276
Query: 1291 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1350
SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1277 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1336
Query: 1351 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1410
FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1337 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1396
Query: 1411 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1443
KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1397 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1429
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 2682 bits (6951), Expect = 0.0
Identities = 1323/1357 (97%), Positives = 1323/1357 (97%), Gaps = 34/1357 (2%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 958 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 991 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1046
ASHVAQANLKLLDVSKIFPIAEIA EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
Query: 1047 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1106
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
Query: 1107 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
Query: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
Query: 1227 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1286
CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
Sbjct: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
Query: 1287 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1323
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 488 bits (1255), Expect = e-137
Identities = 298/717 (41%), Positives = 413/717 (57%), Gaps = 46/717 (6%)
Query: 273 DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323
+ + ++T+LLL++ +P+ + ++ RGH I+I LF P +
Sbjct: 152 NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
Query: 324 TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381
EP R V++QGAAGIGKS LA +V W G+L+ RF ++FY +CRE+ QS S+
Sbjct: 206 RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
Query: 382 ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441
+LI AP+++++ PERLLFI+DG DE +P CL W + +P + LL
Sbjct: 266 DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
Query: 442 SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501
SL+ K +LPE S LIT R TAL+ L LE R VE+LGFSE+ RKEYFY+YF + QA
Sbjct: 326 SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
Query: 502 RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561
+ F V+ N+ L+ +C VP V W+ CTCL QQ++ L TS+TTT + + YL +Q
Sbjct: 386 QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
Query: 562 QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614
+P P+L R LCSLAA+G+W +K LF DLRKHGLDG +S FL M I Q+
Sbjct: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
Query: 615 IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672
YSFIHL FQEFFAAM Y+L E E G G D+ + L Y F A T+R
Sbjct: 506 CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
Query: 673 FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726
FL GLL++E +E ++S +L+QW+ S LQ SLE CLYE +
Sbjct: 562 FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
Query: 727 NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777
+ F+ Q ++HF+ + + + + ME +V +FC+K R + L L E R S
Sbjct: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
Query: 778 TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836
+ T++V L + DAY + L + L NL EL L N+L VK LC+ LR P
Sbjct: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
Query: 837 CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896
C L+ LRL C +++ C+DL+ L AN+ LT +DLS N + G LC+ LR P C+L
Sbjct: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
Query: 897 QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Q +QL C L S CQ++ASVL +P L ELDL N L+D+G+RLLC+GLRHP C+L
Sbjct: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
Score = 145 bits (367), Expect = 2e-34
Identities = 77/160 (48%), Positives = 101/160 (63%), Gaps = 2/160 (1%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 881
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLG 957
+ SL+ELDL N L D+GV LLCEGLRHP CKL +RLG
Sbjct: 882 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLG 921
Score = 145 bits (365), Expect = 4e-34
Identities = 81/159 (50%), Positives = 103/159 (64%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L C L S C+ L+ V
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L A+ +L+ELDL N+L D G+ LL EGL+HPAC+L +L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975
Score = 139 bits (349), Expect = 3e-32
Identities = 78/162 (48%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL C L +
Sbjct: 868 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+AN L ELDLSFN L D G L + L+ P+C+LQ+L L SCGLT+ C
Sbjct: 928 AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
++L L + +L +L L N L D GVRLLC+ L HP CKL
Sbjct: 988 ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029
Score = 90.9 bits (224), Expect = 8e-18
Identities = 53/122 (43%), Positives = 69/122 (56%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL+ NL+ELDLS N L + L + L+ P C L+ L L CGLTA+ C++L F L
Sbjct: 936 VLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLG 995
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
NQTLT+L L+ N L D G + LC+RL P CKL+ L L L LA++ P
Sbjct: 996 INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
Query: 923 SL 924
L
Sbjct: 1056 YL 1057
Score = 54.7 bits (130), Expect = 6e-07
Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66
RL+ YLE L+ ELK+F+L L + G+ P EK +E+A L+ +G + A
Sbjct: 12 RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
Query: 67 WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126
W LAL T+E++ + L + Q + P PS LG+ S V + + P
Sbjct: 70 WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
Query: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171
+ RR R + D + R ++ S Y L +H +P Q
Sbjct: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
Score = 50.8 bits (120), Expect = 9e-06
Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 26/98 (26%)
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
+ LA+ L +P+L EL L +N L GV+LLC+GLRHP CKL L
Sbjct: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNL--------------- 747
Query: 972 EMSNSTSSLKRQRLGS----ERAASHVAQANLKLLDVS 1005
LKR R+ S + +A+ +A NL +D+S
Sbjct: 748 -------RLKRCRISSSACEDLSAALIANKNLTRMDLS 778
Score = 37.4 bits (85), Expect = 0.11
Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 8/84 (9%)
Query: 769 LIEGRQHRSTWSPTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAV 825
L EG QH P + W+ +T + L+ L + + L +L L+ N+L + V
Sbjct: 961 LAEGLQH-----PACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGV 1015
Query: 826 KSLCKTLRRPRCLLETLRLAGCGL 849
+ LCK L P C L L L G L
Sbjct: 1016 RLLCKRLSHPGCKLRVLWLFGMDL 1039
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 461 bits (1187), Expect = e-129
Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LVSC LTS CCQDLASVLS S SL
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
L + +N L D GV +LCE ++P C L +LG
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890
Score = 133 bits (334), Expect = 1e-30
Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL + L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
+ +LT L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS +
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981
+L L L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL+
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972
Query: 982 RQRLGS 987
+ LG+
Sbjct: 973 KLSLGN 978
Score = 132 bits (331), Expect = 3e-30
Identities = 73/166 (43%), Positives = 99/166 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 839 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 899 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LG
Sbjct: 959 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 896 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 956 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 1016 SALETLQEEKPEL 1028
Score = 39.3 bits (90), Expect = 0.028
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 461 bits (1187), Expect = e-129
Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LVSC LTS CCQDLASVLS S SL
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
L + +N L D GV +LCE ++P C L +LG
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890
Score = 133 bits (334), Expect = 1e-30
Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL + L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
+ +LT L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS +
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981
+L L L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL+
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972
Query: 982 RQRLGS 987
+ LG+
Sbjct: 973 KLSLGN 978
Score = 132 bits (331), Expect = 3e-30
Identities = 73/166 (43%), Positives = 99/166 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 839 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 899 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LG
Sbjct: 959 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 896 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 956 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 1016 SALETLQEEKPEL 1028
Score = 39.3 bits (90), Expect = 0.028
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 461 bits (1185), Expect = e-129
Identities = 287/723 (39%), Positives = 404/723 (55%), Gaps = 51/723 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LV+ GLTS CC L+SVLS + +L
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQR 984
L L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL++
Sbjct: 859 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 918
Query: 985 LGS 987
LG+
Sbjct: 919 LGN 921
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 959 SALETLQEEKPEL 971
Score = 39.3 bits (90), Expect = 0.028
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 440 bits (1132), Expect = e-123
Identities = 282/720 (39%), Positives = 396/720 (55%), Gaps = 45/720 (6%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
EGR S+ + L R + + I VL +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLKRQRLGS 987
L+ N L D G++LLCEGL HP CKL L + +T D + S+ SL++ LG+
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 921
Score = 132 bits (331), Expect = 3e-30
Identities = 73/166 (43%), Positives = 99/166 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LG
Sbjct: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 959 SALETLQEEKPEL 971
Score = 39.3 bits (90), Expect = 0.028
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 434 bits (1115), Expect = e-121
Identities = 274/689 (39%), Positives = 381/689 (55%), Gaps = 44/689 (6%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
EGR S+ + L R + + I VL +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
L ELDLS N+L ++ LC L+ C L+ L L GLT+ C L+ L NQ LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 801
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
L L N L D G K LC+ L P CKLQ L+L +C LTS CC DL+++L++S SL++L
Sbjct: 802 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 861
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
L N+L D+GV + CE L+ +C L LG
Sbjct: 862 LGNNDLGDLGVMMFCEVLKQQSCLLQNLG 890
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 782 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 841
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 842 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 901
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 902 SALETLQEEKPEL 914
Score = 39.3 bits (90), Expect = 0.028
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 423 bits (1088), Expect = e-118
Identities = 256/651 (39%), Positives = 368/651 (56%), Gaps = 17/651 (2%)
Query: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
Query: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
Query: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
Query: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
Query: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
Query: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Query: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
Query: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
Query: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
Query: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
Query: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL S
Sbjct: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLES 824
Score = 128 bits (321), Expect = 5e-29
Identities = 70/166 (42%), Positives = 98/166 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLG
Sbjct: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG 992
Score = 124 bits (310), Expect = 9e-28
Identities = 72/160 (45%), Positives = 89/160 (55%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
L + L +++L QN L G+ L + L+ P CKL LG
Sbjct: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLG 1049
Score = 111 bits (278), Expect = 4e-24
Identities = 71/182 (39%), Positives = 100/182 (54%), Gaps = 1/182 (0%)
Query: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLG-KPSVMTPTEGLDTGEMSNSTSSLKRQRL 985
LDL N L D GV+LLC+ RHP+C L L V+T LD + + +L+ L
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
Query: 986 GS 987
G+
Sbjct: 965 GN 966
Score = 78.6 bits (192), Expect = 4e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
Query: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
+ L +V ++P L + D +N +DV
Sbjct: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
Score = 45.1 bits (105), Expect = 5e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
Query: 68 DLALHTWEQMGLRSLCAQAQE 88
++L + +M L+ LC +A+E
Sbjct: 73 SVSLKIFGKMNLKDLCERAKE 93
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 343 bits (879), Expect = 9e-94
Identities = 240/768 (31%), Positives = 362/768 (47%), Gaps = 102/768 (13%)
Query: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
Query: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
Query: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
Query: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
Query: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
Query: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
Query: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
Query: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
Query: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---------------------------- 837
NL ELDLS + L S+VK LC L+ PRC
Sbjct: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSK 783
Query: 838 -----------------LLETLRLAGC----------GLTAEDCKDLAFGLRANQTLTEL 870
+L+ LR + C L+A C+DLA L + Q +T L
Sbjct: 784 LTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRL 843
Query: 871 DLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
L FN L D G K LC L P C L+RL+L C L + C+ L+ L + SL L+L
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903
Query: 931 QNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
+N+L D GV+ LCE L P L L EG GE++N+ S
Sbjct: 904 KNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREG--CGELANALS 949
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 118 bits (295), Expect = 5e-26
Identities = 77/190 (40%), Positives = 103/190 (54%), Gaps = 5/190 (2%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLIRLGKPSVMTPTEGLDTGEMSNSTS 978
+ ++K LDL +N+L D GV+LLCE L+ H A + L K ++ T +S+S S
Sbjct: 950 HNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKS 1009
Query: 979 SLKRQRLGSE 988
+ LG+E
Sbjct: 1010 LVNLNLLGNE 1019
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 337 bits (863), Expect = 6e-92
Identities = 254/828 (30%), Positives = 386/828 (46%), Gaps = 107/828 (12%)
Query: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
Query: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
Query: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
Query: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
Query: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
Query: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
Query: 561 A--QPLGP-----QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
A Q P +L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
Query: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
Query: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
Query: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
Query: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
I ++ S P++ +L R +
Sbjct: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
Query: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
Query: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
Query: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
C ++ VL S SL LDL N L+D GV LC L+HP C + L
Sbjct: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIREL 833
Score = 124 bits (310), Expect = 9e-28
Identities = 66/155 (42%), Positives = 88/155 (56%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
+L+ L+L LD V +LCE L HP C L LG
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLG 948
Score = 122 bits (306), Expect = 2e-27
Identities = 66/156 (42%), Positives = 86/156 (55%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
Query: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
LK L L N + D GVR LC L+HP CKL LG
Sbjct: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLG 891
Score = 69.7 bits (169), Expect = 2e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
Query: 922 PSL 924
P L
Sbjct: 970 PHL 972
Score = 38.9 bits (89), Expect = 0.036
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
Query: 69 LALHTWEQMGLRSLCAQAQE 88
+ L+ + Q+ + L +AQE
Sbjct: 71 VTLNLFLQINRKDLWTKAQE 90
Score = 34.3 bits (77), Expect = 0.89
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
Query: 851 AEDCKDL 857
E K L
Sbjct: 956 EETQKIL 962
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 327 bits (837), Expect = 7e-89
Identities = 242/747 (32%), Positives = 371/747 (49%), Gaps = 84/747 (11%)
Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
Query: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
Query: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
Query: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
Query: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC-------------- 837
+W L S+ ++L L ++ + LS S V+ LC+ + C
Sbjct: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPAD 742
Query: 838 -------------------------------LLETLR----------LAGCGLTAEDCKD 856
L E LR L C T + D
Sbjct: 743 AHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWAD 802
Query: 857 LAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS 916
L+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C LT C+DLA+
Sbjct: 803 LSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAA 862
Query: 917 VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEG-LDTGEMSN 975
VL S L L L +N + + GV+ LCEGLR+P CKL L + ++G D ++
Sbjct: 863 VLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQ 922
Query: 976 STSSLKRQRLGSERAASHVAQANLKLL 1002
SSL LG +H+ +K L
Sbjct: 923 EKSSLLCLDLG----LNHIGVKGMKFL 945
Score = 125 bits (313), Expect = 4e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
Score = 111 bits (277), Expect = 6e-24
Identities = 65/155 (41%), Positives = 90/155 (58%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
+DL S LS + SL LDL QN L GV++L E L
Sbjct: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006
Score = 63.5 bits (153), Expect = 1e-09
Identities = 42/125 (33%), Positives = 60/125 (48%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L +L+ +L LDL N + +K LC+ LR+P C L L L GC + C+DL
Sbjct: 917 LTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCS 976
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L NQ+L LDL N L +G K L + L S L+ L+L + + L +
Sbjct: 977 ALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEE 1036
Query: 920 ASPSL 924
+P L
Sbjct: 1037 KNPQL 1041
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 327 bits (837), Expect = 7e-89
Identities = 243/702 (34%), Positives = 355/702 (50%), Gaps = 75/702 (10%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 ----------------------IEGRQH---------------RSTWSPTMVVLFRWVPV 792
+E +Q RST V + P
Sbjct: 630 LENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPD 689
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 690 T-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATP 747
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT C
Sbjct: 748 EQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASC 807
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DLA+VL S L L L +N + D GV+ LCEGL +P CKL
Sbjct: 808 KDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 849
Score = 113 bits (282), Expect = 2e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 916
Score = 97.8 bits (242), Expect = 7e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
Score = 53.9 bits (128), Expect = 1e-06
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 838 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 894
Query: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 895 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 954
Query: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
LRQ + L+ L+L + + + L V +P L
Sbjct: 955 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 323 bits (829), Expect = 6e-88
Identities = 226/719 (31%), Positives = 357/719 (49%), Gaps = 100/719 (13%)
Query: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
Query: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
Query: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
Query: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
Query: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
Query: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
Query: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
Query: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
Query: 831 TLRRPRCLLETLRLAGCGLTAE------------DCKDLAFGLRA--------------- 863
LR P C L+ L + + + D K L+F L
Sbjct: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720
Query: 864 -----------------------------NQTLTELDLSFNVLTDAGAKHLCQRLRQPSC 894
N+ LT L++S N L D G LC+ L P
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDT 779
Query: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
L L L C L+ CC+ ++ +L + S++ LDL N L D G++ LCE L+HP C L
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCL 838
Score = 140 bits (353), Expect = 9e-33
Identities = 76/177 (42%), Positives = 106/177 (59%), Gaps = 2/177 (1%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--KPSVMTPTEGLDTGE 972
L+ S +L++L+L N LD GV +LCE LRHP C L LG K T+ L T E
Sbjct: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973
Score = 110 bits (274), Expect = 1e-23
Identities = 65/160 (40%), Positives = 94/160 (58%), Gaps = 1/160 (0%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
L ++ +LK L + N + DVGV+LLC L H C+L LG
Sbjct: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
Query: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
+ L +++M + LC + +E G++ ++
Sbjct: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
Score = 42.7 bits (99), Expect = 0.003
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
Query: 860 GLRANQTLTELD 871
N LT D
Sbjct: 973 EEERNPNLTITD 984
Score = 42.4 bits (98), Expect = 0.003
Identities = 40/146 (27%), Positives = 68/146 (46%), Gaps = 14/146 (9%)
Query: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL----SFNVL 877
H +KSL + P+ +++L + C + +D AF +A L E + + +++
Sbjct: 532 HQCLKSLGER-GNPQGQVDSLAIFYCLF---EMQDPAFVKQAVNLLQEANFHIIDNVDLV 587
Query: 878 TDAGAKHLCQRLRQPSCKLQRL--QLVSCGLTSD----CCQDLASVLSASPSLKELDLQQ 931
A C LR+ +Q + + TSD C + SVL+ S L+EL +Q
Sbjct: 588 VSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQD 647
Query: 932 NNLDDVGVRLLCEGLRHPACKLIRLG 957
+ L + C LRHP+C+L +LG
Sbjct: 648 STLSESTFVTWCNQLRHPSCRLQKLG 673
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 322 bits (824), Expect = 2e-87
Identities = 209/657 (31%), Positives = 339/657 (51%), Gaps = 34/657 (5%)
Query: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
Query: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
Query: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
Query: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
Query: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
Query: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Query: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
Query: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
Query: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
Query: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKL 928
Score = 137 bits (344), Expect = 1e-31
Identities = 77/166 (46%), Positives = 94/166 (56%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLG
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLG 1100
Score = 115 bits (288), Expect = 3e-25
Identities = 65/162 (40%), Positives = 91/162 (56%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
LA L + L L L N ++D GV+LLCE +R P+C L
Sbjct: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHL 1039
Score = 108 bits (271), Expect = 3e-23
Identities = 60/148 (40%), Positives = 81/148 (54%)
Query: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
Query: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
Query: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLG 957
QNN G+ LC P L +G
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIG 1157
Score = 68.2 bits (165), Expect = 6e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
Score = 39.3 bits (90), Expect = 0.028
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
Query: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
AW ++ +E M LR+L +A++ HSP P
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 316 bits (809), Expect = 1e-85
Identities = 244/729 (33%), Positives = 357/729 (48%), Gaps = 101/729 (13%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
++ R T+ T+ R + W S+ NLK L++ + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688
Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
S+V+ LC + R C L+ L LAG
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748
Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
C L T E + + L+ANQ+L L LS NVL D GA
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 945 GLRHPACKL 953
GL +P CKL
Sbjct: 869 GLSYPDCKL 877
Score = 113 bits (282), Expect = 2e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 944
Score = 97.8 bits (242), Expect = 7e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Score = 53.9 bits (128), Expect = 1e-06
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 866 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 922
Query: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 923 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 982
Query: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
LRQ + L+ L+L + + + L V +P L
Sbjct: 983 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 1018
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 316 bits (809), Expect = 1e-85
Identities = 244/729 (33%), Positives = 357/729 (48%), Gaps = 101/729 (13%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
++ R T+ T+ R + W S+ NLK L++ + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688
Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
S+V+ LC + R C L+ L LAG
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748
Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
C L T E + + L+ANQ+L L LS NVL D GA
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 945 GLRHPACKL 953
GL +P CKL
Sbjct: 869 GLSYPDCKL 877
Score = 112 bits (280), Expect = 3e-24
Identities = 67/164 (40%), Positives = 86/164 (52%), Gaps = 1/164 (0%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L+ L + SL LDL N + G+ +LC+ L +P C L L
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHL 936
Score = 72.4 bits (176), Expect = 3e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
Query: 912 QDLASVLSASPSL 924
+ L V +P L
Sbjct: 949 KLLEEVKEKNPKL 961
>gi|7662404 caspase recruitment domain family, member 8 [Homo sapiens]
Length = 431
Score = 303 bits (775), Expect = 1e-81
Identities = 171/384 (44%), Positives = 231/384 (60%), Gaps = 16/384 (4%)
Query: 1049 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1107
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
Query: 1108 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
Query: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
Query: 1227 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1286
+ KAIDD E +F VR+ PP+ PL G Y VS S + L+++PKEL+L YRSPGE
Sbjct: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292
Query: 1287 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP 1346
Q FS+FY G + I+L++ +K+ TLVW+ VKP DL PP P
Sbjct: 293 IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGA 345
Query: 1347 QLLHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQS 1405
FV + QL AR+ ++ VLD L +VL++ + E V E TR S+ L S+ +
Sbjct: 346 A---FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEK 402
Query: 1406 WDRKCKDGLYQALKETHPHLIMEL 1429
D L++++ E P+L+ L
Sbjct: 403 KGDLALDVLFRSISERDPYLVSYL 426
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 296 bits (759), Expect = 7e-80
Identities = 240/745 (32%), Positives = 355/745 (47%), Gaps = 83/745 (11%)
Query: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
Query: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
Query: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
Query: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
Query: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
Query: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
Query: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
R++E F C +S+ + ++WV L+ +P
Sbjct: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
Query: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
Query: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
R V + + L L+ + L G S S K L +
Sbjct: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
Query: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
Query: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
Query: 944 EGLRHPACKLIRLGKPSVMTPTEGL 968
L+H C L L SV + L
Sbjct: 834 AVLQHQGCGLQTLSLASVELSEQSL 858
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 281 bits (719), Expect = 3e-75
Identities = 199/667 (29%), Positives = 327/667 (49%), Gaps = 48/667 (7%)
Query: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
Query: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
Query: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
Query: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
Query: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
Query: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
Query: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
Query: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
Query: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
Query: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
Query: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL----CEGLRHP 949
C+LQ L+L C T DL + L + LK L L++N+L++ G L E L
Sbjct: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIE 847
Query: 950 ACKLIRL 956
C L +L
Sbjct: 848 NCNLTQL 854
Score = 110 bits (275), Expect = 1e-23
Identities = 73/207 (35%), Positives = 93/207 (44%), Gaps = 51/207 (24%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLA------------ 845
Q L VL ++L+ L++ + AVK LC+ LR PRC L+ LRL
Sbjct: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
Query: 846 ---------------------------------------GCGLTAEDCKDLAFGLRANQT 866
C LT C+ LA LR ++
Sbjct: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868
Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
LT L L+ N L D GAKH+ L C LQRL L C LT +CCQD+ S L + +LK
Sbjct: 869 LTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKS 928
Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKL 953
LDL N+L D GV LLCE L++P C L
Sbjct: 929 LDLSFNSLKDDGVILLCEALKNPDCTL 955
Score = 108 bits (269), Expect = 5e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Score = 69.7 bits (169), Expect = 2e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
Query: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
Query: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
Query: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
N + G LC+ S + +R +++ C
Sbjct: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
Score = 33.9 bits (76), Expect = 1.2
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Query: 69 LALHTWEQMGLRSLC 83
+ + + M +C
Sbjct: 100 VTSNIFAIMNCDKMC 114
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 252 bits (643), Expect = 2e-66
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
Query: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
Query: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
Query: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
Query: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
Query: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
Query: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
Query: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
Query: 719 LHCLYETRNKTFL 731
LYE + K +
Sbjct: 564 EFSLYEAKIKNLV 576
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 250 bits (638), Expect = 8e-66
Identities = 191/650 (29%), Positives = 309/650 (47%), Gaps = 41/650 (6%)
Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
Query: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
Query: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
Query: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
Query: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
Query: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
Query: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
Query: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L
Sbjct: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISL 780
Score = 111 bits (278), Expect = 4e-24
Identities = 59/154 (38%), Positives = 85/154 (55%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVM 962
+ N ++D G++LLC GLRHP C L+ +G M
Sbjct: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECM 900
Score = 109 bits (273), Expect = 2e-23
Identities = 64/168 (38%), Positives = 94/168 (55%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKP 959
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +G P
Sbjct: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
Score = 70.5 bits (171), Expect = 1e-11
Identities = 42/127 (33%), Positives = 63/127 (49%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Q + V+ L+ L++ N + + ++ LC LR P C+L + L C LT+ C+ L
Sbjct: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L N+TL L+L N L + G L + L P C L+ + L GL + Q L +V
Sbjct: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
Query: 918 LSASPSL 924
PSL
Sbjct: 970 KERKPSL 976
Score = 34.7 bits (78), Expect = 0.68
Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLD 969
+++ S+ SL+EL + N+L+ + R+L + L H +CKL R K S ++ G +
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKL-RTLKLSYVSTASGFE 679
Score = 34.3 bits (77), Expect = 0.89
Identities = 20/61 (32%), Positives = 32/61 (52%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + L SVL + L+ L+L N L + V L ++L P C+L+ + L GL
Sbjct: 901 LTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
Query: 852 E 852
+
Sbjct: 961 Q 961
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 144 bits (364), Expect = 5e-34
Identities = 79/156 (50%), Positives = 98/156 (62%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
L + +L +L L N L D GVRLLC+ L HP CKL
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 255
Score = 144 bits (363), Expect = 6e-34
Identities = 74/154 (48%), Positives = 97/154 (62%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+ SL+ELDL N L D+GV LLCEGLRHP CKL
Sbjct: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
Score = 115 bits (287), Expect = 4e-25
Identities = 61/135 (45%), Positives = 86/135 (63%), Gaps = 2/135 (1%)
Query: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
Query: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
Query: 939 VRLLCEGLRHPACKL 953
+RLLC+GLRHP C+L
Sbjct: 127 LRLLCQGLRHPVCRL 141
Score = 103 bits (257), Expect = 1e-21
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
Query: 912 QDLASVLSASPSL 924
LA++ P L
Sbjct: 271 SRLAALRVTKPYL 283
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (323), Expect = 3e-29
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 971 GEMSNSTSSLKRQRLGSER 989
+ S +SL+ LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 121 bits (304), Expect = 4e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
Score = 119 bits (297), Expect = 3e-26
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
Query: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
+S SSL AA+ +A +L+ LD+S
Sbjct: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
Score = 108 bits (270), Expect = 4e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L N L D G++LLCEGL P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Score = 81.6 bits (200), Expect = 5e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
Query: 922 PSLK 925
PSL+
Sbjct: 455 PSLR 458
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (323), Expect = 3e-29
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 971 GEMSNSTSSLKRQRLGSER 989
+ S +SL+ LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 121 bits (304), Expect = 4e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
Score = 119 bits (297), Expect = 3e-26
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
Query: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
+S SSL AA+ +A +L+ LD+S
Sbjct: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
Score = 108 bits (270), Expect = 4e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L N L D G++LLCEGL P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Score = 81.6 bits (200), Expect = 5e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
Query: 922 PSLK 925
PSL+
Sbjct: 455 PSLR 458
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (323), Expect = 3e-29
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 971 GEMSNSTSSLKRQRLGSER 989
+ S +SL+ LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 121 bits (304), Expect = 4e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
Score = 119 bits (297), Expect = 3e-26
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
Query: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
+S SSL AA+ +A +L+ LD+S
Sbjct: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
Score = 108 bits (270), Expect = 4e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L N L D G++LLCEGL P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Score = 81.6 bits (200), Expect = 5e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
Query: 922 PSLK 925
PSL+
Sbjct: 455 PSLR 458
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (323), Expect = 3e-29
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 971 GEMSNSTSSLKRQRLGSER 989
+ S +SL+ LGS +
Sbjct: 220 CGIVASKASLRELALGSNK 238
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 121 bits (304), Expect = 4e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
Score = 119 bits (297), Expect = 3e-26
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
Query: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
+S SSL AA+ +A +L+ LD+S
Sbjct: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
Score = 108 bits (270), Expect = 4e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
L N L D G++LLCEGL P C+L +L
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Score = 81.6 bits (200), Expect = 5e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
Query: 922 PSLK 925
PSL+
Sbjct: 455 PSLR 458
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,368,199
Number of Sequences: 37866
Number of extensions: 3082771
Number of successful extensions: 10481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 9638
Number of HSP's gapped (non-prelim): 630
length of query: 1443
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1328
effective length of database: 13,892,928
effective search space: 18449808384
effective search space used: 18449808384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.