Guide to the Human Genome
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Search of human proteins with 14719829

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14719829 NLR family, pyrin domain containing 1 isoform 1
[Homo sapiens]
         (1473 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...  2997   0.0  
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...  2925   0.0  
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...  2885   0.0  
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...  2813   0.0  
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...  2753   0.0  
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...   492   e-139
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...   464   e-130
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...   463   e-130
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...   463   e-130
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...   450   e-126
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...   443   e-124
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]     427   e-119
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...   341   3e-93
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]      339   1e-92
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]       333   9e-91
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...   330   6e-90
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]     324   4e-88
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]   322   1e-87
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...   319   1e-86
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...   319   1e-86
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]      314   3e-85
gi|7662404 caspase recruitment domain family, member 8 [Homo sap...   303   1e-81
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]      281   3e-75
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]     252   2e-66
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]    250   6e-66
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...   151   5e-36
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]          141   5e-33
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]          141   5e-33
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]          141   5e-33
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]          141   5e-33

>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1473

 Score = 2997 bits (7769), Expect = 0.0
 Identities = 1473/1473 (100%), Positives = 1473/1473 (100%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
            TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080

Query: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140

Query: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200

Query: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260

Query: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320
            KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
Sbjct: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320

Query: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380
            SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380

Query: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440
            FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440

Query: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473
            KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 1443

 Score = 2925 bits (7583), Expect = 0.0
 Identities = 1443/1473 (97%), Positives = 1443/1473 (97%), Gaps = 30/1473 (2%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG   
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957

Query: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
                                       KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 958  ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990

Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 991  ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050

Query: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110

Query: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170

Query: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230

Query: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320
            KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF
Sbjct: 1231 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1290

Query: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380
            SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1291 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1350

Query: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440
            FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1351 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1410

Query: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473
            KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1411 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1443


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1429

 Score = 2885 bits (7479), Expect = 0.0
 Identities = 1429/1473 (97%), Positives = 1429/1473 (97%), Gaps = 44/1473 (2%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
            TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080

Query: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140

Query: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200

Query: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260

Query: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320
                                                        KELELCYRSPGEDQLF
Sbjct: 1261 --------------------------------------------KELELCYRSPGEDQLF 1276

Query: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380
            SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1277 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1336

Query: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440
            FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1337 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1396

Query: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473
            KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1397 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1429


>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
            sapiens]
          Length = 1399

 Score = 2813 bits (7293), Expect = 0.0
 Identities = 1399/1473 (94%), Positives = 1399/1473 (94%), Gaps = 74/1473 (5%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG   
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957

Query: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
                                       KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 958  ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990

Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1080
            ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW
Sbjct: 991  ASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFW 1050

Query: 1081 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1140
            GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN
Sbjct: 1051 GPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEIN 1110

Query: 1141 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1200
            PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV
Sbjct: 1111 PQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARV 1170

Query: 1201 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1260
            ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR
Sbjct: 1171 ELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIR 1230

Query: 1261 KAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLF 1320
                                                        KELELCYRSPGEDQLF
Sbjct: 1231 --------------------------------------------KELELCYRSPGEDQLF 1246

Query: 1321 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1380
            SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH
Sbjct: 1247 SEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLH 1306

Query: 1381 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1440
            FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC
Sbjct: 1307 FVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKC 1366

Query: 1441 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1473
            KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
Sbjct: 1367 KDGLYQALKETHPHLIMELWEKGSKKGLLPLSS 1399


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
            sapiens]
          Length = 1375

 Score = 2753 bits (7137), Expect = 0.0
 Identities = 1353/1357 (99%), Positives = 1353/1357 (99%), Gaps = 4/1357 (0%)

Query: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
            MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1    MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60

Query: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
            YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61   YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120

Query: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
            IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121  IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180

Query: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
            AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181  AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240

Query: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
            PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241  PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300

Query: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
            PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301  PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360

Query: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
            FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361  FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420

Query: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
            EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421  EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480

Query: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
            FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481  FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540

Query: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
            TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541  TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600

Query: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
            ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601  ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660

Query: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
            GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661  GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720

Query: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
            CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721  CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780

Query: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
            PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781  PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840

Query: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
            TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841  TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900

Query: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
            LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901  LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960

Query: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
            TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961  TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020

Query: 1021 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1076
            ASHVAQANLKLLDVSKIFPIAEIA    EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080

Query: 1077 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1136
            DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140

Query: 1137 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
            GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200

Query: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
            PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260

Query: 1257 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1316
            CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
Sbjct: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320

Query: 1317 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1353
            DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
            sapiens]
          Length = 1061

 Score =  492 bits (1267), Expect = e-139
 Identities = 325/813 (39%), Positives = 448/813 (55%), Gaps = 65/813 (7%)

Query: 273  DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323
            + + ++T+LLL++       +P+  +     ++  RGH          I+I  LF P  +
Sbjct: 152  NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205

Query: 324  TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381
              EP R V++QGAAGIGKS LA +V   W  G+L+  RF ++FY +CRE+ QS    S+ 
Sbjct: 206  RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265

Query: 382  ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441
            +LI        AP+++++  PERLLFI+DG DE      +P    CL W + +P + LL 
Sbjct: 266  DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325

Query: 442  SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501
            SL+ K +LPE S LIT R TAL+ L   LE  R VE+LGFSE+ RKEYFY+YF +  QA 
Sbjct: 326  SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385

Query: 502  RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561
            + F  V+ N+ L+ +C VP V W+ CTCL QQ++    L  TS+TTT + + YL   +Q 
Sbjct: 386  QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445

Query: 562  QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614
            +P  P+L      R LCSLAA+G+W +K LF   DLRKHGLDG  +S FL M I Q+   
Sbjct: 446  KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505

Query: 615  IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672
                YSFIHL FQEFFAAM Y+L E E G G       D+ + L  Y      F A T+R
Sbjct: 506  CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561

Query: 673  FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726
            FL GLL++E    +E     ++S     +L+QW+ S        LQ  SLE   CLYE +
Sbjct: 562  FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621

Query: 727  NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777
             + F+ Q ++HF+ + +  + + ME +V +FC+K  R  + L L         E R   S
Sbjct: 622  EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681

Query: 778  TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836
              + T++V L     + DAY + L + L    NL EL L  N+L    VK LC+ LR P 
Sbjct: 682  AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741

Query: 837  CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896
            C L+ LRL  C +++  C+DL+  L AN+ LT +DLS N +   G   LC+ LR P C+L
Sbjct: 742  CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801

Query: 897  QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
            Q +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G+RLLC+GLRHP C+L  L
Sbjct: 802  QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861

Query: 957  GL----------DQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNS 1006
             L          D+   +  + Q LR L+    +L         V+   EGL        
Sbjct: 862  WLKICRLTAAACDELASTLSVNQSLRELDLSLNEL-----GDLGVLLLCEGLRHPTCKLQ 916

Query: 1007 TSSLKRQRLGSE--RAASHVAQA--NLKLLDVS 1035
            T  L   RLGS      S V QA  NL+ LD+S
Sbjct: 917  TLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949



 Score =  149 bits (376), Expect = 2e-35
 Identities = 85/174 (48%), Positives = 110/174 (63%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L  C L S  C+ L+ V
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           L A+ +L+ELDL  N+L D G+ LL EGL+HPAC+L +L LD   L+ +  + L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990



 Score =  145 bits (366), Expect = 3e-34
 Identities = 87/190 (45%), Positives = 110/190 (57%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  C L +
Sbjct: 868  LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+ L+  L+AN  L ELDLSFN L D G   L + L+ P+C+LQ+L L SCGLT+  C
Sbjct: 928  AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
            ++L   L  + +L +L L  N L D GVRLLC+ L HP CKL  L L    L+      L
Sbjct: 988  ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 1047

Query: 972  RALEQEKPQL 981
             AL   KP L
Sbjct: 1048 AALRVTKPYL 1057



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)

Query: 8   RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66
           RL+ YLE L+  ELK+F+L L     +    G+ P    EK   +E+A  L+  +G + A
Sbjct: 12  RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69

Query: 67  WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126
           W LAL T+E++  + L  + Q       + P  PS   LG+ S      V +    + P 
Sbjct: 70  WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126

Query: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171
              +   RR  R + D + R    ++ S  Y  L    +H +P Q
Sbjct: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score =  464 bits (1193), Expect = e-130
 Identities = 285/709 (40%), Positives = 397/709 (55%), Gaps = 50/709 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LV+ GLTS CC  L+SVLS + +L 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
            L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 859 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958

Query: 912 QDLASVLSASPSL 924
             L ++    P L
Sbjct: 959 SALETLQEEKPEL 971



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
           sapiens]
          Length = 1036

 Score =  463 bits (1192), Expect = e-130
 Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
            L + +N L D GV +LCE  ++P C L +LGL  + L+
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897



 Score =  148 bits (374), Expect = 3e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018

Query: 972  RALEQEKPQLLI 983
              L++EKP+L +
Sbjct: 1019 ETLQEEKPELTV 1030



 Score =  136 bits (342), Expect = 2e-31
 Identities = 76/172 (44%), Positives = 101/172 (58%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
           +L  L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
           sapiens]
          Length = 1036

 Score =  463 bits (1192), Expect = e-130
 Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798

Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858

Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
            L + +N L D GV +LCE  ++P C L +LGL  + L+
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897



 Score =  148 bits (374), Expect = 3e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018

Query: 972  RALEQEKPQLLI 983
              L++EKP+L +
Sbjct: 1019 ETLQEEKPELTV 1030



 Score =  136 bits (342), Expect = 2e-31
 Identities = 76/172 (44%), Positives = 101/172 (58%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
           +L  L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score =  450 bits (1158), Expect = e-126
 Identities = 282/715 (39%), Positives = 396/715 (55%), Gaps = 44/715 (6%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+    V+ L L 
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
                         EGR           S+ +     L R     +  + I   VL   +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
            L ELDLS N+L    ++ LC  L+   C L+ L L   GLT+  C  L+  L  NQ LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 801

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
            L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC DL+++L++S SL++L 
Sbjct: 802 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 861

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
           L  N+L D+GV + CE L+  +C L  LGL +   + E +  L  L++EKP+L +
Sbjct: 862 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 916



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
           sapiens]
          Length = 979

 Score =  443 bits (1140), Expect = e-124
 Identities = 280/706 (39%), Positives = 389/706 (55%), Gaps = 44/706 (6%)

Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262

Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322

Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382

Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442

Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502

Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562

Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622

Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+    V+ L L 
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682

Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
                         EGR           S+ +     L R     +  + I   VL   +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
            L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L  + +LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
            L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + +L  L 
Sbjct: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
           L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907



 Score =  148 bits (374), Expect = 3e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
            DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961

Query: 972 RALEQEKPQLLI 983
             L++EKP+L +
Sbjct: 962 ETLQEEKPELTV 973



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68

Query: 68 DLALHTWEQMGLRSLCAQAQ 87
           +A+  +  +  R L  +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score =  427 bits (1097), Expect = e-119
 Identities = 257/656 (39%), Positives = 372/656 (56%), Gaps = 17/656 (2%)

Query: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
           +P+IV+LQGAAG+GK+TL R+    W  G LY  RF++VFY + RE+ Q K  S A+LI 
Sbjct: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234

Query: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
           KD  +T  PI +I+ +P  LLFI+D  DE  +  +EP   LC  W+Q  P   L+ SLL 
Sbjct: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294

Query: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
           K +LPEAS L+T R T  + L   L+   +VE+LG SE +R+EY Y++F D+R A++ F 
Sbjct: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354

Query: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
            +KSN+ L+++C VP V W ACTCL QQM++   +TLT +TTT L   Y++         
Sbjct: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414

Query: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
             + P   QLR LC +AA+GIW    +F  ++LR+ GL  + +S+F+   I+Q +     
Sbjct: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474

Query: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
            Y F HL  QEFFAAM Y+L+     G  S     DL+  L++             FL G
Sbjct: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534

Query: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
           LL+++  +++E  F+C++S      L+Q +  L        Q   LE  HCLYET++K F
Sbjct: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594

Query: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
           ++Q M  F ++ + +   + LLV +FC+K  R ++ ++L            T +    W 
Sbjct: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654

Query: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
                + WQ L SVL    +L+ELDL  ++L  SA+  L   LR P C L+ L L     
Sbjct: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714

Query: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
             + C+D++  L  N+ L  LDL  + + D G K LC+ L+ P CKLQ L+L SC LT  
Sbjct: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773

Query: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
           CC ++++ L  S SL  L+L  NNL D GV+LLCE LRHP C L RL L+   L++
Sbjct: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829



 Score =  134 bits (338), Expect = 5e-31
 Identities = 79/186 (42%), Positives = 102/186 (54%)

Query: 798  QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
            + L + L   ++L  LDL  N L  + VK LC   R P C L+ L L GC LT   C DL
Sbjct: 890  EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949

Query: 858  AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
            A  +  N  L  LDL  N L D G K LC  LR P+C +QRL L  CGLTS CCQDL+S 
Sbjct: 950  ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009

Query: 918  LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
            L  +  L +++L QN L   G+  L + L+ P CKL  LGL +    +E ++ L A+   
Sbjct: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069

Query: 978  KPQLLI 983
             P L+I
Sbjct: 1070 NPHLII 1075



 Score =  132 bits (332), Expect = 2e-30
 Identities = 74/180 (41%), Positives = 105/180 (58%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A  + L   L   + L  L L+ N L    VK +   L+  +C L++L L  C  T+
Sbjct: 827  LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
               + L+  L  N++LT LDL  N L D G K LC   R PSC LQ L+L+ C LT+ CC
Sbjct: 887  LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
             DLASV+  +P+L+ LDL  N+L D GV++LC+ LR+P C + RLGL+   L+    Q+L
Sbjct: 947  LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDL 1006



 Score =  114 bits (284), Expect = 9e-25
 Identities = 69/175 (39%), Positives = 97/175 (55%)

Query: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
           +++L  L+LS N+L    V+ LC+ LR P+C LE L L  CGLT   C+ L+  L +N+ 
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844

Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
           LT L L+ NVL D G K +   L+   C L+ L L  C  TS   + L++ L  + SL  
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904

Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
           LDL  N L D GV+LLC+  RHP+C L  L L    L++    +L ++    P L
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A    L SV+    NL+ LDL  N L    VK LC  LR P C ++ L L  CGLT+
Sbjct: 941  LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+DL+  L  N+ L +++L+ N L   G   L + L+ P CKLQ L L       +  
Sbjct: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060

Query: 912  QDLASVLSASPSL-KELDLQQNNLDDV 937
            + L +V  ++P L  + D   +N +DV
Sbjct: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
          L  YLE L KEEL  F+L L  K       G TP    K +  E +A+ +   Y  ++AW
Sbjct: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72

Query: 68 DLALHTWEQMGLRSLCAQAQE 88
           ++L  + +M L+ LC +A+E
Sbjct: 73 SVSLKIFGKMNLKDLCERAKE 93


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
           sapiens]
          Length = 1043

 Score =  341 bits (874), Expect = 3e-93
 Identities = 238/761 (31%), Positives = 359/761 (47%), Gaps = 100/761 (13%)

Query: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
           SWP D+V     ++    E++ L  P     + + ++L G AG+GK+TLA Q    W  G
Sbjct: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255

Query: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
            L+  RF +VFY SC ++   K  + AELI  D     API + +S+PE+LLFI+DG +E
Sbjct: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315

Query: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
              ++ E  SE       C  W Q  P   +L SLL K ++P A+ LIT +T  +++L  
Sbjct: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373

Query: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
           SL    +V++ GF+    + YF R+F D  +  +  + ++ N+ L+  C  P V W  C+
Sbjct: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433

Query: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
           CL Q   R   L   ++TTT+L  ++ +       +         Q R LCSLA EG+W 
Sbjct: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493

Query: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
               F+ +D    GL+   I +  +  ILQ+ +      +F HL FQEFFAAMS+VLE+ 
Sbjct: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553

Query: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
           +    HS    +++  L+   +    +      F  GLL+    RE+E+  HC++S    
Sbjct: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613

Query: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
             L++W   L       LQ H L   HCL+E++ + F  +++    E+ + +  D EL  
Sbjct: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673

Query: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
            +FC+K  + + KL+L          S +  +L R + + +          W  + S L 
Sbjct: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723

Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---------------------------- 837
              NL ELDLS + L  S+VK LC  L+ PRC                            
Sbjct: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSK 783

Query: 838 -----------------LLETLRLAGC----------GLTAEDCKDLAFGLRANQTLTEL 870
                            +L+ LR + C           L+A  C+DLA  L + Q +T L
Sbjct: 784 LTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRL 843

Query: 871 DLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
            L FN L D G K LC  L  P C L+RL+L  C L +  C+ L+  L  + SL  L+L 
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903

Query: 931 QNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           +N+L D GV+ LCE L  P   L  L L   + + E   EL
Sbjct: 904 KNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGEL 944



 Score =  122 bits (306), Expect = 3e-27
 Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)

Query: 800  LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
            L   L   R+L  L+LS NSL    VK LC+ L RP   L++L L+GC  T E C +LA 
Sbjct: 887  LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946

Query: 860  GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
             L  N  +  LDL  N L D G K LC+ L+ P   L  L L  C LT+ CCQ L SVLS
Sbjct: 947  ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005

Query: 920  ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
            +S SL  L+L  N LD  GV++LC+ L+   C+L +LG
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043



 Score =  116 bits (291), Expect = 1e-25
 Identities = 74/172 (43%), Positives = 95/172 (55%), Gaps = 5/172 (2%)

Query: 800  LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
            L S+  VTR    L L  N L    +K LC  L  P+C LE L L  C L A  CK L+ 
Sbjct: 834  LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889

Query: 860  GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
             L  N++LT L+LS N L D G K LC+ L +P   LQ L L  C  T + C +LA+ LS
Sbjct: 890  ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949

Query: 920  ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
             + ++K LDL +N+L D GV+LLCE L+ P   L  LGL +  L+    Q L
Sbjct: 950  HNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHL 1000



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 23/51 (45%), Positives = 31/51 (60%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
            +T A  Q LFSVL  +++L  L+L GN L    VK LCK L++  C L+ L
Sbjct: 992  LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 1/82 (1%)

Query: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
           + S L  + +L ELDL  + L    V+ LC  L++P CK+ +L     T    ++  + A
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777

Query: 974 LE-QEKPQLLIFSRRKPSVMTP 994
           L+   K   L FS  K  +  P
Sbjct: 778 LQGNSKLTHLNFSSNKLGMTVP 799


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score =  339 bits (869), Expect = 1e-92
 Identities = 257/846 (30%), Positives = 395/846 (46%), Gaps = 107/846 (12%)

Query: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
           + E+ ++  EK E    PWA +     +    L   H+P    WE ++   L       W
Sbjct: 26  FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85

Query: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
               E+   K        R H +    L+         P+  Y E  +    E+ D +  
Sbjct: 86  TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141

Query: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
                    V+L+G  GIGK+TL R+V   W  G L+ DRF  VF+ +  E+      SL
Sbjct: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198

Query: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
            EL+ +D   +   I  I S+PER+LFI+DG ++  + LQ   ++L   W Q QP   +L
Sbjct: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257

Query: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
            SLL K +LPE+S LI     A+Q     L   + +++LGFSES +K YF  +F ++ +A
Sbjct: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317

Query: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
           ++ F  V+ N  L+ LC  P+  WL CTC+ Q+++R E L + S+ TT L   +L    +
Sbjct: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377

Query: 561 A--QPLGP-----QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
           A  Q   P     +L+ LC+LAAEGIW    +FS  DLR++GL  +    ++ M +LQ  
Sbjct: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437

Query: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
                ++F+HLC QEF AAM Y+L+  K     +           ++  +  L   GI  
Sbjct: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493

Query: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
                   F+ G+ ++E    +E  F   LS+   + + Q + SL             E 
Sbjct: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545

Query: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
              L+ET+ K F+T+VM  FEE+ + +     L++ +FC+K  +H+  L++         
Sbjct: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605

Query: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
                                       I   ++ S   P++ +L           R + 
Sbjct: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665

Query: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
            T  Y+     LF  +    +LK L L G SLS S ++ LC+TL+ P C +E L L  C 
Sbjct: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725

Query: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
           +++E C+D+A  L  N  L  L L  N L D G   LC+ L+   C L+RL L+ C LTS
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785

Query: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMR 968
             C  ++ VL  S SL  LDL  N L+D GV  LC  L+HP C +  L L    L+ +  
Sbjct: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845

Query: 969 QELRAL 974
           +++ A+
Sbjct: 846 KDIAAV 851



 Score =  136 bits (342), Expect = 2e-31
 Identities = 73/181 (40%), Positives = 104/181 (57%)

Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
           VL  +++L  LDL  N+L  + V SLC  L+ P C +  L L GC LT++ CKD+A  L 
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853

Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
            N  L  L L  N + D G + LC  L+ P CKL+ L L +C +T  CC D+A+ L A  
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913

Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
           +L+ L+L    LD   V +LCE L HP C L  LGL ++   +E ++ L ++E++ P L 
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973

Query: 983 I 983
           I
Sbjct: 974 I 974



 Score =  124 bits (310), Expect = 9e-28
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           SVL     LK L L  N L    +  LC+ L+   C LE L L  C LT+  C  ++  L
Sbjct: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
             +++L+ LDL  N L D G   LC  L+ P C ++ L L+ C LTSD C+D+A+VL  +
Sbjct: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855

Query: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
             LK L L  N + D GVR LC  L+HP CKL  LGL
Sbjct: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 44/123 (35%), Positives = 57/123 (46%)

Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
           +VL     LK L L  N +  + V+ LC  L+ P C LE L L  C +T   C D+A  L
Sbjct: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909

Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
            A +TL  L+L +  L       LC+ L  P C LQ L L   G   +  + L SV    
Sbjct: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969

Query: 922 PSL 924
           P L
Sbjct: 970 PHL 972



 Score = 38.9 bits (89), Expect = 0.037
 Identities = 25/80 (31%), Positives = 41/80 (51%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
          L  YL+ L+KEE  +F+ LL              A+ +K S  +VA  L   Y  ++AW+
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70

Query: 69 LALHTWEQMGLRSLCAQAQE 88
          + L+ + Q+  + L  +AQE
Sbjct: 71 VTLNLFLQINRKDLWTKAQE 90



 Score = 34.3 bits (77), Expect = 0.91
 Identities = 22/67 (32%), Positives = 31/67 (46%)

Query: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
           P+T A    + + L   + L+ L+L   +L   AV  LC+ L  P C L+ L L   G  
Sbjct: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955

Query: 851 AEDCKDL 857
            E  K L
Sbjct: 956 EETQKIL 962


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score =  333 bits (853), Expect = 9e-91
 Identities = 240/726 (33%), Positives = 365/726 (50%), Gaps = 79/726 (10%)

Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
           V+L G AG+GK+TLA+++   W    L   +F++ FY SCREL++    S AEL+ +D  
Sbjct: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267

Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
                I  IL++  ++LF++DG DE G        ++C  W + +P   LLGSLL + +L
Sbjct: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327

Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
           P+A+ L+T R  AL++L    E+  ++ V GF E  R+ YF R+F DE QA+RAF L++S
Sbjct: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387

Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
           N  L+ L   P V W+ CT L  QM++ E    T  T T L L +L     Q   L   L
Sbjct: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447

Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
           R L  LAA+G+W + ++   +DL + G+  + +  FL   IL++  +    YSFIHL FQ
Sbjct: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507

Query: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
           +F  A+ Y L  E+E+ R  H+  I D++K L   G+  L      +   +  GL +++ 
Sbjct: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565

Query: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
            +E+E  F CR+S   ++ Q +    +  +  HS      E L CLYE++ +  + +VMA
Sbjct: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623

Query: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
            F+E+ + +   ++++  +FC+K  R+++K+ L    E      T S +   + R     
Sbjct: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682

Query: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC-------------- 837
               +W  L S+    ++L  L ++ + LS S V+ LC+ +    C              
Sbjct: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPAD 742

Query: 838 -------------------------------LLETLR----------LAGCGLTAEDCKD 856
                                          L E LR          L  C  T +   D
Sbjct: 743 AHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWAD 802

Query: 857 LAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS 916
           L+  L  NQ+LT ++LS N L D GAK L   LR P C LQRL L +C LT   C+DLA+
Sbjct: 803 LSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAA 862

Query: 917 VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQ 976
           VL  S  L  L L +N + + GV+ LCEGLR+P CKL  L L    ++ +   +L  L Q
Sbjct: 863 VLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQ 922

Query: 977 EKPQLL 982
           EK  LL
Sbjct: 923 EKSSLL 928



 Score =  126 bits (316), Expect = 2e-28
 Identities = 76/192 (39%), Positives = 109/192 (56%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A  + L +VL V+R L  L L+ N + ++ VK LC+ LR P C L+TL L  C +T+
Sbjct: 852  LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
            + C DL   L+   +L  LDL  N +   G K LC+ LR+P C L+ L L  C +    C
Sbjct: 912  DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
            +DL S LS + SL  LDL QN L   GV++L E L   +  L  L L     +DE+ + L
Sbjct: 972  EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLL 1031

Query: 972  RALEQEKPQLLI 983
              +E++ PQL+I
Sbjct: 1032 EEIEEKNPQLII 1043



 Score =  125 bits (313), Expect = 4e-28
 Identities = 70/161 (43%), Positives = 91/161 (56%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W  L   L+V ++L  ++LS N L     K L  TLR P+C L+ L L  C LT  
Sbjct: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
           +CKDLA  L  ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C 
Sbjct: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           DL  +L    SL  LDL  N++   G++ LCE LR P C L
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
           1 [Homo sapiens]
          Length = 1009

 Score =  330 bits (846), Expect = 6e-90
 Identities = 246/713 (34%), Positives = 361/713 (50%), Gaps = 75/713 (10%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 ----------------------IEGRQH---------------RSTWSPTMVVLFRWVPV 792
                                 +E +Q                RST     V +    P 
Sbjct: 630 LENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPD 689

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           T AY     + +   + L  L L+G+     + +  LC  LR  +C L+ LRL G   T 
Sbjct: 690 T-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATP 747

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           E   +  + L+ANQ+L  L LS NVL D GA  L + + +P   LQ L L +C LT   C
Sbjct: 748 EQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASC 807

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
           +DLA+VL  S  L  L L +N + D GV+ LCEGL +P CKL  L L Q +++
Sbjct: 808 KDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSIT 860



 Score =  113 bits (282), Expect = 2e-24
 Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  L L
Sbjct: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 910



 Score =  105 bits (263), Expect = 2e-22
 Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L SC L    C
Sbjct: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
           Q L S L ++  L+ LDL QN+L   G+  L   LR    + K++RL   +T L  E+++
Sbjct: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 978

Query: 970 ELRALEQEKPQLLI 983
            L  ++++ P+L I
Sbjct: 979 LLEEVKEKNPKLTI 992


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score =  324 bits (830), Expect = 4e-88
 Identities = 228/724 (31%), Positives = 359/724 (49%), Gaps = 100/724 (13%)

Query: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
           LF P    ++PR VI+QG  GIGK+TL  ++  AW   +++ DRF + FYF CREL +  
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197

Query: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
             SLA+LI ++     API +I+S+PERLLF++D  +E    L EP S+LC    + +P 
Sbjct: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257

Query: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
             LL SLL K +LPEAS LI  +    + L   +  +   +  GF+ES R  YF  +F D
Sbjct: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317

Query: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
            ++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++   ++ 
Sbjct: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377

Query: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
                +   GP      QL+ LCSLAAEG+W     F  DDLR++G+  A I   L   I
Sbjct: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437

Query: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
           L ++     SY F+H+C QEF AA+ Y+L+        +  C+ +L     EK   A+ I
Sbjct: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497

Query: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
               G     FL GLL+ + + +++  F  +LSQ   + + Q + SL     P     SL
Sbjct: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
              +CL+E ++  F+ Q +   +E    +  +++L+V  +C+K+   ++KL         
Sbjct: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611

Query: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
           +  +H ST   +++            W  + SVL  + +L+EL +  ++LS S   + C 
Sbjct: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660

Query: 831 TLRRPRCLLETLRLAGCGLTAE------------DCKDLAFGLRA--------------- 863
            LR P C L+ L +     + +            D K L+F L                 
Sbjct: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720

Query: 864 -----------------------------NQTLTELDLSFNVLTDAGAKHLCQRLRQPSC 894
                                        N+ LT L++S N L D G   LC+ L  P  
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDT 779

Query: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLI 954
            L  L L  C L+  CC+ ++ +L  + S++ LDL  N L D G++ LCE L+HP C L 
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLD 839

Query: 955 RLGL 958
            L L
Sbjct: 840 SLCL 843



 Score =  153 bits (386), Expect = 1e-36
 Identities = 80/186 (43%), Positives = 113/186 (60%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           + +  +L   ++++ LDLS N L    +K+LC+ L+ P C L++L L  C +TA  C+DL
Sbjct: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L +NQ L  L +  N + D G + LC+ L    C+L+ L L  CGLTS CC+DLASV
Sbjct: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
           L+ S +L++L+L  N LD  GV +LCE LRHP C L  LGL +T   +E +  L A E+ 
Sbjct: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEER 976

Query: 978 KPQLLI 983
            P L I
Sbjct: 977 NPNLTI 982



 Score =  115 bits (287), Expect = 4e-25
 Identities = 68/177 (38%), Positives = 104/177 (58%), Gaps = 1/177 (0%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           ++L  +L   + L  L++S N L  + V  LC+ L  P  +L  L LA C L+ + C+ +
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           +  L  N+++  LDLS NVL D G K LC+ L+ P C L  L LV C +T+  C+DLAS 
Sbjct: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
           L ++ +LK L +  N + DVGV+LLC  L H  C+L  LGL++  L+    ++L ++
Sbjct: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 46/110 (41%), Positives = 60/110 (54%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A  + L S L   +NLK L +  N +    V+ LC+ L    C LE L L  CGLT+
Sbjct: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
             CKDLA  L  ++TL +L+L+ N L   G   LC+ LR P C LQ L L
Sbjct: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)

Query: 9  LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
          L  YLE LKKEE ++F+  L               + +K S  E+A+ L+  Y EQ+AW+
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70

Query: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
          + L  +++M  + LC +  +E  G++ ++
Sbjct: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 26/72 (36%), Positives = 36/72 (50%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL  ++ L++L+L+ N+L H+ V  LC+ LR P C L+ L L       E    L  
Sbjct: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972

Query: 860 GLRANQTLTELD 871
               N  LT  D
Sbjct: 973 EEERNPNLTITD 984


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score =  322 bits (826), Expect = 1e-87
 Identities = 210/660 (31%), Positives = 341/660 (51%), Gaps = 34/660 (5%)

Query: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
           PR V+L G +GIGKS LAR++   W +G LY   F +VF+   RE+ + K  S+ E I +
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338

Query: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
           +   + AP+ +I+SRPERLLFI+DG D+ G VL    ++LC  W++ QP   L+ SLL K
Sbjct: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397

Query: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
            +LPE+  ++T R    + L   +   R++ V G S   R          E Q  +  R 
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457

Query: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
           + +N+EL   C VP V  L C  L  Q    E +   ++T T L   ++   L  + +  
Sbjct: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517

Query: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
           +         L+  C +A EG+W +K++F  DDL   GL  + +     M I L +    
Sbjct: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577

Query: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
             Y+F HL  Q+F AA+ YVLE  +   + + C + +EKT     L+  G H +      
Sbjct: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634

Query: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
           RFL GL+S++  R +E +  C +  G  + L+ WV  L    QP+      +L++ HCL+
Sbjct: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692

Query: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
           ET++K F+   +  F+E+ + +  +++L+  +FC++   +++K+++    I  R   +  
Sbjct: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752

Query: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
            P + +  R   + +  W+   S+L    +L++LDL  + L+  A+K+LC  LR P C +
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812

Query: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
           +TL      +T    + L   + AN+ L  L+L    L +   +  C+ L+ P C L+ L
Sbjct: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871

Query: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLD 959
           +L  CGLT  C   ++ +L+ SPSLK L L  N + D GV  L + LR   C L +L L+
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931



 Score =  139 bits (351), Expect = 2e-32
 Identities = 80/180 (44%), Positives = 100/180 (55%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T    Q L S L   R+L  L LS NSL +  V  LC+++R P C L+ L L  C L  
Sbjct: 935  ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C  LA  L  N  LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 995  AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
            + L+ V+S S  LK LDL  N L D GV  LCEGL+     L RLGL    L+ +  + L
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114



 Score =  116 bits (290), Expect = 2e-25
 Identities = 66/174 (37%), Positives = 96/174 (55%)

Query: 810  LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
            L  L LS N +  + VK LC+ +R P C L+ L L  C LTA  C+ L+  +  ++ L  
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069

Query: 870  LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
            LDL+ N L D G   LC+ L+Q +  L RL L +CGLTSDCC+ L+  LS +  L  L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129

Query: 930  QQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
             QNN    G+  LC     P   L  +GL +     ++R+ L  ++  KP+++I
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183



 Score =  115 bits (289), Expect = 2e-25
 Identities = 67/167 (40%), Positives = 93/167 (55%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A +  +  +L  + +LK L L+GN ++   V  L   LR  +C L+ L L  CG+TA
Sbjct: 878  LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+ LA  L +N++LT L LS N L + G   LC+ +R P C LQRL L  C L +  C
Sbjct: 938  TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
              LA  L  +  L  L L  N ++D GV+LLCE +R P+C L  L L
Sbjct: 998  GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 39/110 (35%), Positives = 60/110 (54%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T A  + L  V+  +R+LK LDL+ N+L    V +LC+ L++   +L  L L  CGLT+
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
            + C+ L+  L  N+ LT L+L  N  +  G   LC     P+  LQ + L
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)

Query: 5   AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
           ++G   C  E L KEE + F+ LL  K+ S S++   P    + + +E  + L+ + YG 
Sbjct: 62  SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119

Query: 64  QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
             AW  ++  +E M LR+L  +A++    HSP  P
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
           isoform 3 [Homo sapiens]
          Length = 1037

 Score =  319 bits (818), Expect = 1e-86
 Identities = 247/740 (33%), Positives = 363/740 (49%), Gaps = 101/740 (13%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
                   ++    R T+  T+    R    +   W    S+     NLK L++  + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688

Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
            S+V+ LC  + R  C L+                            L LAG        
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748

Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
                       C L          T E   +  + L+ANQ+L  L LS NVL D GA  
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808

Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
           L + + +P   LQ L L +C LT   C+DLA+VL  S  L  L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868

Query: 945 GLRHPACKLIRLGLDQTTLS 964
           GL +P CKL  L L Q +++
Sbjct: 869 GLSYPDCKLQTLVLQQCSIT 888



 Score =  113 bits (282), Expect = 2e-24
 Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  L L
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 938



 Score =  105 bits (263), Expect = 2e-22
 Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 830  LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L SC L    C
Sbjct: 890  LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
            Q L S L ++  L+ LDL QN+L   G+  L   LR    + K++RL   +T L  E+++
Sbjct: 949  QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 1006

Query: 970  ELRALEQEKPQLLI 983
             L  ++++ P+L I
Sbjct: 1007 LLEEVKEKNPKLTI 1020


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
           2 [Homo sapiens]
          Length = 980

 Score =  319 bits (818), Expect = 1e-86
 Identities = 247/740 (33%), Positives = 363/740 (49%), Gaps = 101/740 (13%)

Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
           F P L+ + PR      V+L G AG+GK+TLA++    W    L     ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215

Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
           ++    S AELI KD       I  IL++ +R+LF++DG+DE    PG ++Q+    +C 
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271

Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
            W + +P   LLGSLL + +LP A+ L+T R  AL++L    +Q  +V V GF E  R+ 
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331

Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
           YF R+F DE QA+RAF L++SN  L+ L   P V W+ CT L  QM++ E    T  T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391

Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
            L L +L     Q   L   LR L  LAA+G+W + ++F  +DL + G+  + +  FL  
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451

Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
            IL++  +    YSFIHL FQ+F  A+ Y LE E+G  R  H+  I D++K L   G   
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509

Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
           L      +   FL GL +++  +E+E  F CR+S    + L+Q    L     L      
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569

Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
           E L CLYE++ +     V+A F+E+ + +    E++ C+F +K  + ++KL L       
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629

Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
                   ++    R T+  T+    R    +   W    S+     NLK L++  + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688

Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
            S+V+ LC  + R  C L+                            L LAG        
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748

Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
                       C L          T E   +  + L+ANQ+L  L LS NVL D GA  
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808

Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
           L + + +P   LQ L L +C LT   C+DLA+VL  S  L  L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868

Query: 945 GLRHPACKLIRLGLDQTTLS 964
           GL +P CKL  L L Q +++
Sbjct: 869 GLSYPDCKLQTLVLQQCSIT 888



 Score =  120 bits (302), Expect = 7e-27
 Identities = 73/191 (38%), Positives = 101/191 (52%), Gaps = 1/191 (0%)

Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
           T   W   F VLK  ++LK L LS N L       L KT+ RP+  L+ L L  C LT  
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833

Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
            CKDLA  L  ++ LT L L+ N + D G K LC+ L  P CKLQ L L  C +T   C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893

Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
            L+  L  + SL  LDL  N +   G+ +LC+ L +P C L  L L     + E+++ L 
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLE 952

Query: 973 ALEQEKPQLLI 983
            ++++ P+L I
Sbjct: 953 EVKEKNPKLTI 963



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + L +VL V++ L  L L+ N +  + VK LC+ L  P C L+TL L  C +T 
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ L+  L+   +LT LDLS N +   G   LCQ L  P+C L+ L+L +     +  
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948

Query: 912 QDLASVLSASPSL 924
           + L  V   +P L
Sbjct: 949 KLLEEVKEKNPKL 961


>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
          Length = 892

 Score =  314 bits (805), Expect = 3e-85
 Identities = 248/760 (32%), Positives = 369/760 (48%), Gaps = 83/760 (10%)

Query: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
           ++FT+LL+        ++ L     P+     R        LF    + + P  V+LQG 
Sbjct: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203

Query: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
           AGIGK+  A+++   W  G+LY  +    F+  C EL +     SLA+LI        AP
Sbjct: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263

Query: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
           + Q+L++P+RLLFILDG DE    L  P +  C    +      +LG LL K +LP A  
Sbjct: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322

Query: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
           L+T R  A   L   L   +  EV GFS+  +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382

Query: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
           ALC VP+V W+ CT L QQ++    L+ TSKTTT++ L ++   L + P+  GP+L    
Sbjct: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442

Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
           R+LC LA EG+  ++  F+  +L +  L G+ + T FL      G+L+     ++Y FI 
Sbjct: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499

Query: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
             FQEF AA+SY+LED       +  +  L +       H +    TTRFL GLLS E  
Sbjct: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556

Query: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
           R++E  F C +S+   +  ++WV                    L+   +P          
Sbjct: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616

Query: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
           + LE L+CLYET+   F+ Q +  F E+ +       M++ V ++C++     + L+LI 
Sbjct: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676

Query: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
                           R V   +   + L   L+ +       L G S S    K L  +
Sbjct: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714

Query: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
           L          P C L +L L+ C L    C+DL+  LRA   LTEL L  N L++AG +
Sbjct: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774

Query: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
            L + L  P C++Q ++ V         Q L  +L  SP+L  LDL    L    V  LC
Sbjct: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833

Query: 944 EGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
             L+H  C L  L L    LS++  QEL+A+++ KP L+I
Sbjct: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873


>gi|7662404 caspase recruitment domain family, member 8 [Homo sapiens]
          Length = 431

 Score =  303 bits (775), Expect = 1e-81
 Identities = 171/384 (44%), Positives = 231/384 (60%), Gaps = 16/384 (4%)

Query: 1079 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1137
            F GP G V  E++DK  N Y V FP AG Y W  TGL F++R+ VTV I F  W Q L  
Sbjct: 56   FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115

Query: 1138 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
            ++     W+V GPL D+ AEP  AV  +HLPHF++LQG  VD S F +AHFK EGM+LE 
Sbjct: 116  DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174

Query: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
            PARVE  + VLE+PSFS +G+LL++       IP+TS  L+Y+  HPE++ FHLYL+PSD
Sbjct: 175  PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234

Query: 1257 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1316
              + KAIDD E +F  VR+   PP+ PL  G  Y VS S +  L+++PKEL+L YRSPGE
Sbjct: 235  ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292

Query: 1317 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAP 1376
             Q FS+FY G +   I+L++ +K+  TLVW+  VKP DL       PP       P    
Sbjct: 293  IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPP-------PFSGA 345

Query: 1377 QLLHFVDQYREQLIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQS 1435
                FV +   QL AR+  ++ VLD L   +VL++ + E V  E TR S+   L S+ + 
Sbjct: 346  A---FVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEK 402

Query: 1436 WDRKCKDGLYQALKETHPHLIMEL 1459
                  D L++++ E  P+L+  L
Sbjct: 403  KGDLALDVLFRSISERDPYLVSYL 426


>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
          Length = 1048

 Score =  281 bits (720), Expect = 3e-75
 Identities = 202/686 (29%), Positives = 335/686 (48%), Gaps = 51/686 (7%)

Query: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
           ++P+ V +QGA GIGK+ LA++V   W R + Y  +    FYF C+E+ Q+   S +ELI
Sbjct: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260

Query: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
            +    +   + +I+S+P++LL +LDG +E    L +   +L   W Q  P   LL SLL
Sbjct: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320

Query: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
            KT+LPEA+ LI  R T+ Q   P L+    V + GF+   + +YF  YF    +  +  
Sbjct: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380

Query: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
                N  L+++C VP V W+ C+ L QQM+R   LT +    T++ + Y+       A+
Sbjct: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440

Query: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
               +    QL  LC LAA+ +W +K +   +DL +  LD   ++ FL M IL      +
Sbjct: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500

Query: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
           +H     Y F  + FQEFFAA+ YVL   ++ +  H    +++++ + +      + +  
Sbjct: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555

Query: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
             FL G L++     +E  F C++S G  R L++ +P L     P       +  +CL+E
Sbjct: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615

Query: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
            R + F++Q +  + ++ + +  + E+ V  FC+K  +++ +++L           +   
Sbjct: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675

Query: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
            H  + +P    L RW       WQ L SV      L+ L ++ + L    +K+L   LR
Sbjct: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728

Query: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
            P+C L+ L L     T  + +DL   L  NQ L  L++    +     K LC+ LR P 
Sbjct: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787

Query: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           C+LQ L+L  C  T     DL + L  +  LK L L++N+L++ G   L         +L
Sbjct: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQL 841

Query: 954 IRLGLDQTTLSDEMRQELRA-LEQEK 978
            RL ++   L+    + L + L Q K
Sbjct: 842 ERLSIENCNLTQLTCESLASCLRQSK 867



 Score =  112 bits (279), Expect = 3e-24
 Identities = 77/235 (32%), Positives = 104/235 (44%), Gaps = 51/235 (21%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLA------------ 845
           Q L  VL   ++L+ L++    +   AVK LC+ LR PRC L+ LRL             
Sbjct: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808

Query: 846 ---------------------------------------GCGLTAEDCKDLAFGLRANQT 866
                                                   C LT   C+ LA  LR ++ 
Sbjct: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868

Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
           LT L L+ N L D GAKH+   L    C LQRL L  C LT +CCQD+ S L  + +LK 
Sbjct: 869 LTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKS 928

Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
           LDL  N+L D GV LLCE L++P C L  L L+    +    Q + ++ ++   L
Sbjct: 929 LDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983



 Score =  108 bits (269), Expect = 5e-23
 Identities = 61/153 (39%), Positives = 84/153 (54%)

Query: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
            +T    + L S L+ ++ L  L L+ N+L     K +   L   RC L+ L L  C LT 
Sbjct: 851  LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910

Query: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
              C+D+   L  N+TL  LDLSFN L D G   LC+ L+ P C LQ L+L +C  TS CC
Sbjct: 911  NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970

Query: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
            Q +AS+L  +  L+ LDL +N +   G+  LCE
Sbjct: 971  QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)

Query: 709  LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
            L+L+ +SLE+    Y +         +A  E + +  C  T +       C++ S+ +  
Sbjct: 821  LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871

Query: 767  LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
            L L E      G +H   W+       P   ++ R   +T    Q + S L   + LK L
Sbjct: 872  LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929

Query: 814  DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
            DLS NSL    V  LC+ L+ P C L+ L L  C  T+  C+ +A  LR NQ L  LDLS
Sbjct: 930  DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989

Query: 874  FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
             N +   G   LC+     S + +R +++ C
Sbjct: 990  KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 1/137 (0%)

Query: 855 KDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDL 914
           +DL      N  L  L ++ +VL     K L   LR P CKLQ+L L     T    QDL
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTM-LNQDL 751

Query: 915 ASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
             VL+ +  L+ L++Q   ++   V+LLC  LR P C+L  L L+    +  +  +L   
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811

Query: 975 EQEKPQLLIFSRRKPSV 991
            Q    L     RK S+
Sbjct: 812 LQGNGHLKTLILRKNSL 828



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)

Query: 12  YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
           Y+  +  EEL+ F+ LL  +     S+G  P    Q E  S  EV   L+ ++  +RAWD
Sbjct: 44  YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99

Query: 69  LALHTWEQMGLRSLC 83
           +  + +  M    +C
Sbjct: 100 VTSNIFAIMNCDKMC 114


>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
          Length = 655

 Score =  252 bits (643), Expect = 2e-66
 Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)

Query: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
           H +    RE +     W+    N ++ Q+LL+ +P   S + L    +P+   E+    +
Sbjct: 96  HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150

Query: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
            +  LF  G   +  P +V+LQG+AG GK+TLAR++   W  G LY  RF +VFY SC+E
Sbjct: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210

Query: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
           +       L +L+        AP+ +IL +PERLLFILDG DE    LQ P  E  L   
Sbjct: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265

Query: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
              P ++LL  L+ +  LP  S LIT R  AL+NL P L+QAR V +LGFSE  R  YF 
Sbjct: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325

Query: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
            YFTDE+QA RAF +V+ N  L+  C VP + W+ C+ L  QM+R + +  T + +T + 
Sbjct: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385

Query: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
           + Y++  L     G          LR LCSLAAEGI  ++ LF   +LRKH LDG  ++ 
Sbjct: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445

Query: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
           FL     Q    I   YSF H+ FQ+FF AMSY++++++ R GK S    ++++ LE   
Sbjct: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503

Query: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
             G    + T +FLL +   +    +E  F  R+S    ++L  +   ++ +    + + 
Sbjct: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563

Query: 719 LHCLYETRNKTFL 731
              LYE + K  +
Sbjct: 564 EFSLYEAKIKNLV 576


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score =  250 bits (639), Expect = 6e-66
 Identities = 192/652 (29%), Positives = 310/652 (47%), Gaps = 41/652 (6%)

Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
           V L G    GK+ +       W +G+++ +   +V + +  E+ Q    SLAELI KD  
Sbjct: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208

Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
              API  ILS P++LLFIL+ +D   + L    S LC + +Q  P   LL SLL + + 
Sbjct: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268

Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
           P   FLI++R T   N+   L++      L  S   R+ YF  +F D ++A  A +LV  
Sbjct: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328

Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
           ++ L  LC V  + W+ CT L +QM +     L  +T T L  H+LA AL ++       
Sbjct: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388

Query: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
             LG  L+ LC LAA G++     FS +DLR  G   A +S      IL   +     Y 
Sbjct: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447

Query: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
           FIHL  QEF  A+++++         G  ++       EK  +    + +F      F+ 
Sbjct: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496

Query: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
           GLL+    + +E  F  +L    +   +       L        H +   +CLYE R + 
Sbjct: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556

Query: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
           F+  ++    E+ + +++D +++V  +C+ +  H++ L+L   R          PT   +
Sbjct: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616

Query: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
              V     YW+ + S+     +L+EL +  N L+  + + L K L    C L TL+L+ 
Sbjct: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671

Query: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
              TA   +DL   L  N++LT L ++   ++      L   L +P+C++  L L+ C L
Sbjct: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730

Query: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
            +  C+++AS+L +  SL++L L  N L   G+ +LC+ L HP C LI L L
Sbjct: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782



 Score =  123 bits (309), Expect = 1e-27
 Identities = 72/194 (37%), Positives = 109/194 (56%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+     L  VL  +  L++LDL  N L +  V  +   L  P C LE L L+GC  ++
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C+ +A  +  N+ L  L++  N + DAG + LC  LR P+C L  + L  C LTS CC
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           + LASVL+ + +L+ L+L QN+L + GV  L E L  P C L  +GL  T L+ + +Q L
Sbjct: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966

Query: 972 RALEQEKPQLLIFS 985
             +++ KP L+  S
Sbjct: 967 MTVKERKPSLIFLS 980



 Score =  115 bits (289), Expect = 2e-25
 Identities = 61/166 (36%), Positives = 93/166 (56%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +L++L LS N L    +  LC  L  P C L +L L  C LT   C  L   L  + TL 
Sbjct: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           +LDL  N L + G  H+   L  P+C+L+ L L  C  +SD CQ +A V++ +  L+ L+
Sbjct: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
           +  N ++D G++LLC GLRHP C L+ +GL++  L+    + L ++
Sbjct: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASV 912



 Score = 38.9 bits (89), Expect = 0.037
 Identities = 19/67 (28%), Positives = 36/67 (53%)

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           +++ S+     SL+EL +  N+L+ +  R+L + L H +CKL  L L   + +      L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682

Query: 972 RALEQEK 978
           +AL + +
Sbjct: 683 KALARNR 689


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
           sapiens]
          Length = 287

 Score =  151 bits (381), Expect = 5e-36
 Identities = 88/184 (47%), Positives = 108/184 (58%)

Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
           Q + SVL    +L ELDL+GN+L    ++ LC+ LR P C L TL L  C LTA  C +L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159

Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
           A  L  NQ+L ELDLS N L D G   LC+ LR P+CKLQ L+L SCGLT+  C++L   
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219

Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
           L  + +L +L L  N L D GVRLLC+ L HP CKL  L L    L+      L AL   
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279

Query: 978 KPQL 981
           KP L
Sbjct: 280 KPYL 283



 Score =  148 bits (374), Expect = 3e-35
 Identities = 79/172 (45%), Positives = 105/172 (61%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L + L   +NL  +DLSGN +    +  LC+ LR P+C L+ ++L  C L +  C+++A 
Sbjct: 45  LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N  L ELDL+ N L D G + LCQ LR P C+L+ L L  C LT+  C +LAS LS
Sbjct: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
            + SL+ELDL  N L D+GV LLCEGLRHP CKL  L LD   L+ +  + L
Sbjct: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216



 Score =  116 bits (290), Expect = 2e-25
 Identities = 66/153 (43%), Positives = 92/153 (60%), Gaps = 2/153 (1%)

Query: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
           S+S +  ++    L +PR   + L L  C +++  C+DL+  L AN+ LT +DLS N + 
Sbjct: 9   SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66

Query: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
             G   LC+ LR P C+LQ +QL  C L S  CQ++ASVL  +P L ELDL  N L+D+G
Sbjct: 67  FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126

Query: 939 VRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           +RLLC+GLRHP C+L  L L    L+     EL
Sbjct: 127 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159



 Score =  103 bits (257), Expect = 1e-21
 Identities = 61/133 (45%), Positives = 77/133 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A    L S L V ++L+ELDLS N L    V  LC+ LR P C L+TLRL  CGLTA
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C++L F L  NQTLT+L L+ N L D G + LC+RL  P CKL+ L L    L     
Sbjct: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270

Query: 912 QDLASVLSASPSL 924
             LA++    P L
Sbjct: 271 SRLAALRVTKPYL 283



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 2/94 (2%)

Query: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH 948
           L QP  + QRL L  C ++S  C+DL++ L A+ +L  +DL  N +   G+ LLCEGLRH
Sbjct: 22  LLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRH 79

Query: 949 PACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
           P C+L  + L +  L     QE+ ++    P L+
Sbjct: 80  PQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 113


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  141 bits (355), Expect = 5e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455

Query: 980 QLLIFS 985
            L + S
Sbjct: 456 SLRVIS 461



 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (325), Expect = 2e-29
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 972 RALEQEKPQL 981
             +   K  L
Sbjct: 220 CGIVASKASL 229



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  122 bits (305), Expect = 3e-27
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390

Query: 972 RA 973
            A
Sbjct: 391 AA 392



 Score =  115 bits (289), Expect = 2e-25
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  141 bits (355), Expect = 5e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455

Query: 980 QLLIFS 985
            L + S
Sbjct: 456 SLRVIS 461



 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (325), Expect = 2e-29
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 972 RALEQEKPQL 981
             +   K  L
Sbjct: 220 CGIVASKASL 229



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  122 bits (305), Expect = 3e-27
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390

Query: 972 RA 973
            A
Sbjct: 391 AA 392



 Score =  115 bits (289), Expect = 2e-25
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  141 bits (355), Expect = 5e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455

Query: 980 QLLIFS 985
            L + S
Sbjct: 456 SLRVIS 461



 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (325), Expect = 2e-29
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 972 RALEQEKPQL 981
             +   K  L
Sbjct: 220 CGIVASKASL 229



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  122 bits (305), Expect = 3e-27
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390

Query: 972 RA 973
            A
Sbjct: 391 AA 392



 Score =  115 bits (289), Expect = 2e-25
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  141 bits (355), Expect = 5e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455

Query: 980 QLLIFS 985
            L + S
Sbjct: 456 SLRVIS 461



 Score =  130 bits (328), Expect = 7e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258



 Score =  129 bits (325), Expect = 2e-29
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 972 RALEQEKPQL 981
             +   K  L
Sbjct: 220 CGIVASKASL 229



 Score =  126 bits (316), Expect = 2e-28
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221

Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281

Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315



 Score =  122 bits (305), Expect = 3e-27
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270

Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330

Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390

Query: 972 RA 973
            A
Sbjct: 391 AA 392



 Score =  115 bits (289), Expect = 2e-25
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59

Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119

Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427

Query: 838 LLETLRL 844
           LLE L L
Sbjct: 428 LLEQLVL 434


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,356,096
Number of Sequences: 37866
Number of extensions: 3125506
Number of successful extensions: 10745
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 9916
Number of HSP's gapped (non-prelim): 589
length of query: 1473
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1358
effective length of database: 13,892,928
effective search space: 18866596224
effective search space used: 18866596224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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