Guide to the Human Genome
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Search of human proteins with 14602435

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14602435 Williams Beuren syndrome chromosome region 14
isoform beta [Homo sapiens]
         (833 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14602435 Williams Beuren syndrome chromosome region 14 isofor...  1719   0.0  
gi|14602439 Williams Beuren syndrome chromosome region 14 isofor...  1710   0.0  
gi|14602433 Williams Beuren syndrome chromosome region 14 isofor...  1707   0.0  
gi|14602437 Williams Beuren syndrome chromosome region 14 isofor...  1698   0.0  
gi|111955326 MLX interacting protein [Homo sapiens]                   523   e-148
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   105   2e-22
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   102   2e-21
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   101   2e-21
gi|160707881 formin 2 [Homo sapiens]                                   96   2e-19
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         96   2e-19
gi|47132519 Ras association and pleckstrin homology domains 1 is...    95   3e-19
gi|163965366 nascent polypeptide-associated complex alpha subuni...    92   2e-18
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    91   3e-18
gi|116284392 mucin 2 precursor [Homo sapiens]                          89   1e-17
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       85   3e-16
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    84   5e-16
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    83   9e-16
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   82   3e-15
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   82   3e-15
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   82   3e-15
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    82   3e-15
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    81   3e-15
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]         80   6e-15
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 80   8e-15
gi|11386183 WAS protein family, member 2 [Homo sapiens]                80   1e-14
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 79   1e-14
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    79   2e-14
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         78   4e-14
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    78   4e-14
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             77   5e-14

>gi|14602435 Williams Beuren syndrome chromosome region 14 isoform
           beta [Homo sapiens]
          Length = 833

 Score = 1719 bits (4451), Expect = 0.0
 Identities = 833/833 (100%), Positives = 833/833 (100%)

Query: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60
           MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
Sbjct: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60

Query: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120
           SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
Sbjct: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120

Query: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180
           RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
Sbjct: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180

Query: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240
           YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
Sbjct: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240

Query: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300
           QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
Sbjct: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300

Query: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
           DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360

Query: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420
           SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420

Query: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
           PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
Sbjct: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480

Query: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
           EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
Sbjct: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540

Query: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600
           LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
Sbjct: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600

Query: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660
           LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK
Sbjct: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660

Query: 661 RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG 720
           RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG
Sbjct: 661 RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG 720

Query: 721 VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL 780
           VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL
Sbjct: 721 VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL 780

Query: 781 AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL 833
           AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL
Sbjct: 781 AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL 833


>gi|14602439 Williams Beuren syndrome chromosome region 14 isoform
           delta [Homo sapiens]
          Length = 831

 Score = 1710 bits (4428), Expect = 0.0
 Identities = 831/833 (99%), Positives = 831/833 (99%), Gaps = 2/833 (0%)

Query: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60
           MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
Sbjct: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60

Query: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120
           SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
Sbjct: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120

Query: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180
           RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
Sbjct: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180

Query: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240
           YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
Sbjct: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240

Query: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300
           QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
Sbjct: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300

Query: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
           DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360

Query: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420
           SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420

Query: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
           PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
Sbjct: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480

Query: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
           EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
Sbjct: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540

Query: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600
           LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
Sbjct: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600

Query: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660
           LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNK  NRRITHISAEQK
Sbjct: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNK--NRRITHISAEQK 658

Query: 661 RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG 720
           RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG
Sbjct: 659 RRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATG 718

Query: 721 VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL 780
           VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL
Sbjct: 719 VPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSL 778

Query: 781 AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL 833
           AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL
Sbjct: 779 AWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL 831


>gi|14602433 Williams Beuren syndrome chromosome region 14 isoform
           alpha [Homo sapiens]
          Length = 852

 Score = 1707 bits (4421), Expect = 0.0
 Identities = 833/852 (97%), Positives = 833/852 (97%), Gaps = 19/852 (2%)

Query: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60
           MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
Sbjct: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60

Query: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120
           SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
Sbjct: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120

Query: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180
           RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
Sbjct: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180

Query: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240
           YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
Sbjct: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240

Query: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300
           QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
Sbjct: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300

Query: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
           DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360

Query: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420
           SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420

Query: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
           PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
Sbjct: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480

Query: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
           EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
Sbjct: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540

Query: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600
           LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
Sbjct: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600

Query: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660
           LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK
Sbjct: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660

Query: 661 RRFNIKLGFDTLHGLVSTLSAQPSLK-------------------ERAGLQEEAQQLRDE 701
           RRFNIKLGFDTLHGLVSTLSAQPSLK                   ERAGLQEEAQQLRDE
Sbjct: 661 RRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDE 720

Query: 702 IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE 761
           IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE
Sbjct: 721 IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE 780

Query: 762 SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT 821
           SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT
Sbjct: 781 SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT 840

Query: 822 RAVTEGTLGKPL 833
           RAVTEGTLGKPL
Sbjct: 841 RAVTEGTLGKPL 852


>gi|14602437 Williams Beuren syndrome chromosome region 14 isoform
           gamma [Homo sapiens]
          Length = 850

 Score = 1698 bits (4398), Expect = 0.0
 Identities = 831/852 (97%), Positives = 831/852 (97%), Gaps = 21/852 (2%)

Query: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60
           MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD
Sbjct: 1   MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSD 60

Query: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120
           SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI
Sbjct: 61  SLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKI 120

Query: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180
           RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE
Sbjct: 121 RLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMRE 180

Query: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240
           YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR
Sbjct: 181 YHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGR 240

Query: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300
           QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS
Sbjct: 241 QLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDIS 300

Query: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360
           DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN
Sbjct: 301 DFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARN 360

Query: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420
           SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP
Sbjct: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP 420

Query: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
           PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS
Sbjct: 421 PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480

Query: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
           EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA
Sbjct: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540

Query: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600
           LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER
Sbjct: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600

Query: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQK 660
           LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNK  NRRITHISAEQK
Sbjct: 601 LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNK--NRRITHISAEQK 658

Query: 661 RRFNIKLGFDTLHGLVSTLSAQPSLK-------------------ERAGLQEEAQQLRDE 701
           RRFNIKLGFDTLHGLVSTLSAQPSLK                   ERAGLQEEAQQLRDE
Sbjct: 659 RRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDE 718

Query: 702 IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE 761
           IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE
Sbjct: 719 IEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFE 778

Query: 762 SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT 821
           SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT
Sbjct: 779 SFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQAT 838

Query: 822 RAVTEGTLGKPL 833
           RAVTEGTLGKPL
Sbjct: 839 RAVTEGTLGKPL 850


>gi|111955326 MLX interacting protein [Homo sapiens]
          Length = 919

 Score =  523 bits (1348), Expect = e-148
 Identities = 372/940 (39%), Positives = 492/940 (52%), Gaps = 157/940 (16%)

Query: 11  GLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLL------------------------RSQV 46
           G QV       + D D+D+++PS   ++G                           R Q+
Sbjct: 17  GRQVLLKPQVSEDDDDSDTDEPSPPPASGAATPARAHASAAPPPPRAGPGREEPPRRQQI 76

Query: 47  IHSGHFMVSSPHSDSLPRR----------RDQEGSVGPSDFGPRSIDPTLTRLFECLSLA 96
           IHSGHFMVSSPH +  P++            Q  S G +     SID +LT+LFEC++LA
Sbjct: 77  IHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLA 136

Query: 97  YSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGP-EAD 155
           YSGKLVSPKWKNFKGLKL  RDKIRLNNAIWRAWY+QY+++RK+PVC FVTPL G  + D
Sbjct: 137 YSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVD 196

Query: 156 AHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPE 215
            HR+PEA+  EG YWK RIE+V+REYHKWR Y+KKRL++  +++DL +  Q +       
Sbjct: 197 EHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQ-HKDEDLSSLVQDDDML---- 251

Query: 216 QWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLF-TMTQSGPSPLQLPPEDA 274
            W K       PV +   EE+P    LLD +  +S+ SDTLF T++   P     P E A
Sbjct: 252 YWHKHGDGWKTPVPM---EEDP----LLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIA 304

Query: 275 YVGNADMIQPDLTPLQPSLDDFMD----ISDFFTNSRL---PQPPMPSNFPEP-PSFSPV 326
           ++GNADMIQP L PLQP+LD FMD      D F++SR       P  ++ P P P+  P 
Sbjct: 305 HLGNADMIQPGLIPLQPNLD-FMDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPA 363

Query: 327 VDSLFSSGTLGPEV--------PPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLL 378
            +S+  +  L P V        PP + ++ H+           C    + ++     F+ 
Sbjct: 364 QESILPTTAL-PTVSLPDSLIAPPTAPSLAHMD-------EQGC----EHTSRTEDPFIQ 411

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPP-----FPPMAPPTALLQEE--PLF 431
           P D  P  PP  VP P L   P   +P L P P PP      P + PP   L     P F
Sbjct: 412 PTDFGPSEPPLSVPQPFL---PVFTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTF 468

Query: 432 SPRFPFPTVPPAPGVSPLPAPAAF----PPTPQSV----------PSPAPTPFPIELLPL 477
                F  V  AP V    A A      P T  S           P+P+  P  + L P+
Sbjct: 469 HQPQKFAGVNKAPSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPV 528

Query: 478 GYSEPAFGPCFSMPR------GKP---------PAPSPRGQKASPPTLAPATAS--PPTT 520
               P     F  P+      G+P         P P P         +APA  S  P   
Sbjct: 529 T-RPPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPAAFSGQPQAV 587

Query: 521 AGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             ++ P   + + A+   Q+    +  + + R+PG     VPEF  + L          P
Sbjct: 588 IMTSGPLKREGMLASTVSQS-NVVIAPAAIARAPG-----VPEFHSSILVTDLGHGTSSP 641

Query: 581 PPGPATLAPSRPLLVPKAERLSPPAPSGSER-RLSGDLSSMPGPGTLSVRVSPPQPILSR 639
           P   + L PS     P  +    P   GS +  ++G     P  G  S   S   P  S 
Sbjct: 642 PAPVSRLFPSTAQ-DPLGKGEQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSP--SP 698

Query: 640 GRPDSNKT-----------ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPS---- 684
             P +N +           +NR++ HISAEQKRRFNIK+ FD L+ L+S  S   S    
Sbjct: 699 QSPQNNCSGKSDPKNVAALKNRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAIT 758

Query: 685 -----------LKERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRD 733
                       +ER  +QEEA++LR+EIEELNA I  CQQ LPATGVP+T ++FD M+D
Sbjct: 759 LQKTVEYITKLQQERGQMQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHMKD 818

Query: 734 MFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSLAWLDQYCSLPALR 793
           MFD+YV+TRTL NWKFW+FSI+I+PLFESF GMVST+S+  L +T+L+WLDQ+CSLP LR
Sbjct: 819 MFDEYVKTRTLQNWKFWIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILR 878

Query: 794 PTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL 833
           P VL++LRQL TSTSILTDP ++PEQA++AVT   +GK L
Sbjct: 879 PMVLSTLRQLSTSTSILTDPAQLPEQASKAVTR--IGKRL 916


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score =  105 bits (262), Expect = 2e-22
 Identities = 120/405 (29%), Positives = 151/405 (37%), Gaps = 50/405 (12%)

Query: 252 ISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSL--DDFMDISDFFTNSRLP 309
           I   L T +   P  LQ PP       A +  P L  L PSL        S   T   L 
Sbjct: 508 IMPPLETQSSLAPPSLQTPP-------ASLTTPPLENL-PSLAPPPLQTASAPLTTPHLE 559

Query: 310 QPPMPSNFP--EPPS--FSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCP-G 364
            PP P+  P   PPS   +P  ++  S  T  P+ PPA ++         LQ   S P  
Sbjct: 560 TPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP-------LQGLPSPPLS 612

Query: 365 PLDSSAFLSSDFL-LPEDPKPRLPPPPVPPPL--LHYPPPAKVPGLE------PCPPPPF 415
           PL +    +   L LP    P  P PP  PPL  L  P P     L       P  PPP 
Sbjct: 613 PLATPPPQAPPXLALPPLQAP--PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPS 670

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELL 475
           PP+  P +     P+     P    PP+    PL  P + P +P   PS  P P      
Sbjct: 671 PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA---- 726

Query: 476 PLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAA 535
                 P   P   +P   P +P        PP + P  A+PP     + P    +   A
Sbjct: 727 ----PPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLA 782

Query: 536 KPEQALEPPLVSSTLLRSPGSPQE---TVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
           KP     P L +  L   P  P       P  P   LP +P  TP  PP  P  LA   P
Sbjct: 783 KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP--PPQAPPVLA--AP 838

Query: 593 LL-VPKAERLSPPAPSGSERRLSGDLSSMPGPG-TLSVRVSPPQP 635
           LL VP +   SP   +       G  +S+ GP  TL++   PP P
Sbjct: 839 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 883



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 109/356 (30%), Positives = 149/356 (41%), Gaps = 47/356 (13%)

Query: 267 LQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFP--EPPSFS 324
           LQ PP    + +        +P   +   F+ +S   T + L  P  P++ P   PP  +
Sbjct: 400 LQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQA 459

Query: 325 PVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKP 384
           P+  SL +S  L   + PA S ++       LQA +S        A LSS  + P + + 
Sbjct: 460 PL--SLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASH-SPQAPLSSLIMPPLETQS 516

Query: 385 RLPPPPV--PPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPP 442
            L PP +  PP  L  PP   +P L P      PP+   +A     PL +P       PP
Sbjct: 517 SLAPPSLQTPPASLTTPPLENLPSLAP------PPLQTASA-----PLTTPHLE---TPP 562

Query: 443 APGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMP--RGKPPAP-S 499
            P   PL AP    P+P + P P  TP  I   P     P   P  + P  +G P  P S
Sbjct: 563 CPAPCPLQAP----PSPLTTP-PPETPSSIATPP-----PQAPPALASPPLQGLPSPPLS 612

Query: 500 PRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQE 559
           P      PP   P  A PP  A  + P    L   A P     P  ++  LL++P SP  
Sbjct: 613 PLA--TPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQ-APNALAVHLLQAPFSPPP 669

Query: 560 TVPEFPCTFLPP-----TPAPTPPRPPPGPATLAPSRPLLVPKAERLSPP-APSGS 609
           + P     F PP     +P+ TPP   P P+  AP  PL VP +   SPP +PS +
Sbjct: 670 S-PPVQAPFSPPASPPVSPSATPPSQAP-PSLAAP--PLQVPPSPPASPPMSPSAT 721



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 102/380 (26%), Positives = 127/380 (33%), Gaps = 71/380 (18%)

Query: 252 ISDTLFTMTQSGPS----PLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSR 307
           +S +    +Q+ PS    PLQ+PP            P   P+ PS               
Sbjct: 685 VSPSATPPSQAPPSLAAPPLQVPPSP----------PASPPMSPSATPPPQAPPPLAAPP 734

Query: 308 LPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLD 367
           L  PP P   P  P  SP       S T  P VPP  +A         LQ   S P  L 
Sbjct: 735 LQVPPSP---PASPPMSP-------SATPPPRVPPLLAAPP-------LQVPPSPPASLP 777

Query: 368 SSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYP-PPAKVPGLEPCPPPPFPPMAP-PTALL 425
            S            P P+ PP    PPL   P PPA  PG  P  P    PM+P  T   
Sbjct: 778 MSPLAK--------PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPP 829

Query: 426 QEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFG 485
           Q  P+ +   P   VPP+P  SP       PPTP    S +     + L P         
Sbjct: 830 QAPPVLAA--PLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP--------- 878

Query: 486 PCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPL 545
                  G PP PS   +  S     P  A   ++A S    L    +  +   A  PP 
Sbjct: 879 -------GPPPPPS---RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP 928

Query: 546 VSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPA 605
            +      P +     P  P  F     AP P  P  GP +      +   +    + PA
Sbjct: 929 DAELAACHPAA-WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPA 987

Query: 606 PSGSERRLSGDLSSMPGPGT 625
           P        G L   P PGT
Sbjct: 988 P--------GALDPGPSPGT 999



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 105/442 (23%), Positives = 134/442 (30%), Gaps = 117/442 (26%)

Query: 304 TNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCP 363
           T   LP+P  PS  P PP+  P      +S     E  PA+       G  +  A  S  
Sbjct: 185 TEVGLPRPA-PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243

Query: 364 G---PLDSSAFLSSDF-------LLPEDPKPR----LPPPPVPPPLLHYPP--------P 401
               PL S A               P  PKP+    L PP V PP     P        P
Sbjct: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSP 303

Query: 402 AKVPG-----LEPCPPP------------PFPPMAPPTALLQEEPLFSPRFPFPTVPPAP 444
              P        P PPP            P PP+A P  L    P   P       PPA 
Sbjct: 304 LATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPAT 363

Query: 445 GVSPLPAPAAFPP--------------TPQSVPSPA--PTPFPIELLPLGYSEPAFGPCF 488
             S  P     PP               P S+ SP+    P P+ L  L  +     P  
Sbjct: 364 PPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTL 423

Query: 489 -------------------------SMPRGKPPAPSPRGQKASPP---TLAPATA--SPP 518
                                    S P   PP  +P    ASPP   +L+PA +  S P
Sbjct: 424 QATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSP 483

Query: 519 TTA------------GSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEF-- 564
            T                 P  + ++   + + +L PP + +        P E +P    
Sbjct: 484 LTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAP 543

Query: 565 ------------PCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERR 612
                       P    PP PAP P + PP P T  P           ++ P P      
Sbjct: 544 PPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPE-----TPSSIATPPPQAPPAL 598

Query: 613 LSGDLSSMPGPGTLSVRVSPPQ 634
            S  L  +P P    +   PPQ
Sbjct: 599 ASPPLQGLPSPPLSPLATPPPQ 620



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 67/247 (27%), Positives = 86/247 (34%), Gaps = 22/247 (8%)

Query: 377 LLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPP----------PPFPPMAPPTALLQ 426
           L P  P    PPPPV P  L     A   G +P             P   P A PT    
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT---- 80

Query: 427 EEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGP 486
                S R P  + PPA G     AP A   +P  V SP          PLG        
Sbjct: 81  RSAGTSSRNP-ASRPPASGRGE-RAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 138

Query: 487 CFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLV 546
             ++ RGK    +    K S  +      +   T G+ +P + +   AA  E  L  P  
Sbjct: 139 EETVARGK----ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 194

Query: 547 SSTLLRSPGSPQETVPE-FPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPA 605
           S+        P+++V      +   P+PA    RP  G     P+   L   A  LS PA
Sbjct: 195 SARPRPPTEGPRKSVSSASEHSTTEPSPA-ARRRPSAGGGLQRPASRSLSSSATPLSSPA 253

Query: 606 PSGSERR 612
            SG   R
Sbjct: 254 RSGPSAR 260



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/234 (23%), Positives = 74/234 (31%), Gaps = 20/234 (8%)

Query: 417 PMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLP 476
           P A    LL   P  SPR P P  P A  V          P  +          P E  P
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP-ESAP 75

Query: 477 LGYSEPAFGPCFSMPRGKPPAPSPRGQKASP-------PTLAPATASPPTTAG------- 522
                 + G     P  +PPA S RG++A P       P  +P  AS  T  G       
Sbjct: 76  RAGPTRSAGTSSRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 523 ---SNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTP-P 578
              +         T A    AL       T   +PG+P   +             P P P
Sbjct: 135 RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 194

Query: 579 RPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP 632
              P P T  P + +        + P+P+   R  +G     P   +LS   +P
Sbjct: 195 SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  102 bits (253), Expect = 2e-21
 Identities = 109/359 (30%), Positives = 146/359 (40%), Gaps = 45/359 (12%)

Query: 309 PQPPMPSNFP--EPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPL 366
           P  P P       PP  +P      ++  LGP    +SS +   S  + LQ++   P  L
Sbjct: 269 PSQPKPKGLQALRPPQVTPPRKD--AAPALGPL---SSSPLATPSPSAALQSQ--APPTL 321

Query: 367 DSSAFLSSDFLLPEDPKPRLPPPPVPPPLLH-YPPPAKVPGLEPCPPPPFPPMAPPTALL 425
            ++   SS       P P  PP P  PP L   P P   P  +       P +    + L
Sbjct: 322 PATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 381

Query: 426 QEEPLFSPRFPFPTVPPAPGVSPL---PAPAAFPP-TPQSVPSP-APTPFPIELLPLGYS 480
              PL     P P  PPA  + PL   P+P A PP +P + PSP AP    + LL   +S
Sbjct: 382 PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 441

Query: 481 EPAFGPC---FSMPRGKPPAPSPRGQKASPPTLA--------PATASPPTTAGSNNPCLT 529
            P   P    FS P   P +PS      +PP+LA           ASPP +  +  P   
Sbjct: 442 PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 501

Query: 530 QLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTF-----------LPPTPAPTPP 578
               AA P Q  +PP  +   L +P  P + +P  P +F           LP +P  TP 
Sbjct: 502 PPPLAAPPLQLAKPPPQAPPALATP--PLQALPSPPASFPGQAPFSPSASLPMSPLATP- 558

Query: 579 RPPPGPATLAPSRPLL-VPKAERLSPPAPSGSERRLSGDLSSMPGPG-TLSVRVSPPQP 635
            PP  P  LA   PLL VP +   SP   +       G  +S+ GP  TL++   PP P
Sbjct: 559 -PPQAPPVLA--APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 614



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 116/401 (28%), Positives = 147/401 (36%), Gaps = 41/401 (10%)

Query: 264 PSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSF 323
           P PL  P   A      +  P  TP   +       +   T+S LP PP+      PP  
Sbjct: 337 PLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 396

Query: 324 SPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAF-------LSSDF 376
            P   +L       P  PPAS  ++ L+  S  QA N+    L  + F       + + F
Sbjct: 397 PP---ALALPPLQAPPSPPASPPLSPLATPSP-QAPNALAVHLLQAPFSPPPSPPVQAPF 452

Query: 377 LLPEDP--KPRLPPPPVPPPLLHYPP------PAKVPGLEP--CPPPPFPP--MAPPTAL 424
             P  P   P   PP   PP L  PP      P   P + P   PPP  PP   APP  L
Sbjct: 453 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 512

Query: 425 LQEEPLFSPRFPFPTV-----PPA--PGVSPLPAPAAFPPTPQSVPSP-APTPFPIELLP 476
            +  P   P    P +     PPA  PG +P    A+ P +P + P P AP      LL 
Sbjct: 513 AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ 572

Query: 477 LGYSEPAFGPCFSMPRGKPPAPSPRGQKASPP-TLAPATASPPTTAGSNNPCLTQLLTAA 535
           +  S PA  P    PR +PP P P    + P  TLA A   PP  + S +  L+    A 
Sbjct: 573 VPPSPPA-SPTLQAPR-RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG 630

Query: 536 KPEQALEPPLVSSTLLRSP--GSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPL 593
               A   P         P  G+     P+       P      P PP      AP  PL
Sbjct: 631 HSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA-FRGAPGAPL 689

Query: 594 LVPKAERLSPPAPSG--SERRLSGDLSSMPGPGTLSVRVSP 632
             P A    P +  G  +     G  S+ P PG L    SP
Sbjct: 690 PWPPA--TGPGSADGLCTIYETEGPESATPAPGALDPGPSP 728



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 114/393 (29%), Positives = 138/393 (35%), Gaps = 81/393 (20%)

Query: 265 SPLQLPPEDAYVGNADMIQPDLTPLQ--PSLDDFMDISDFFTNSRLPQPP-------MPS 315
           SPL  PP  A    A      L PLQ  PS      +S   T S  PQ P       + +
Sbjct: 387 SPLATPPPQAPPALA------LPPLQAPPSPPASPPLSPLATPS--PQAPNALAVHLLQA 438

Query: 316 NFPEPPSFSPVVDSLFS---SGTLGPEVPPASSAMTHLSGHSRLQARNSCPG--PLDSSA 370
            F  PPS  P V + FS   S  + P   P S A   L+    LQ   S P   P+  SA
Sbjct: 439 PFSPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP-LQVPPSPPASPPMSPSA 495

Query: 371 FLSSDFLLPEDPKPRLPPPPVPPPL-LHYPPPAKVPGLE-------PCPPPPFPPMAP-- 420
                      P P+ PPP   PPL L  PPP   P L        P PP  FP  AP  
Sbjct: 496 ----------TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 545

Query: 421 PTALLQEEPLFSP--------RFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPI 472
           P+A L   PL +P          P   VPP+P  SP       PPTP    S +     +
Sbjct: 546 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 605

Query: 473 ELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLL 532
            L P                G PP PS   +  S     P  A   ++A S    L    
Sbjct: 606 ALAP----------------GPPPPPS---RSPSSTLSGPDLAGHSSSATSTPEELRGYD 646

Query: 533 TAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
           +  +   A  PP  +      P +     P  P  F     AP P  P  GP +      
Sbjct: 647 SGPEGGAAASPPPDAELAACHPAA-WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 705

Query: 593 LLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
           +   +    + PAP        G L   P PGT
Sbjct: 706 IYETEGPESATPAP--------GALDPGPSPGT 730



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 67/247 (27%), Positives = 86/247 (34%), Gaps = 22/247 (8%)

Query: 377 LLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPP----------PPFPPMAPPTALLQ 426
           L P  P    PPPPV P  L     A   G +P             P   P A PT    
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPT---- 80

Query: 427 EEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGP 486
                S R P  + PPA G     AP A   +P  V SP          PLG        
Sbjct: 81  RSAGTSSRNP-ASRPPASGRGE-RAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 138

Query: 487 CFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLV 546
             ++ RGK    +    K S  +      +   T G+ +P + +   AA  E  L  P  
Sbjct: 139 EETVARGK----ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 194

Query: 547 SSTLLRSPGSPQETVPE-FPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPA 605
           S+        P+++V      +   P+PA    RP  G     P+   L   A  LS PA
Sbjct: 195 SARPRPPTEGPRKSVSSASEHSTTEPSPA-ARRRPSAGGGLQRPASRSLSSSATPLSSPA 253

Query: 606 PSGSERR 612
            SG   R
Sbjct: 254 RSGPSAR 260



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 63/223 (28%), Positives = 75/223 (33%), Gaps = 53/223 (23%)

Query: 448 PLPAPAAFPPTPQSVP----SPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP-------- 495
           P PAP+A P  P   P    S A      E  P     P+ G     P  +         
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 249

Query: 496 PAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEP---------PLV 546
            +P+  G  A     APA  S P   G         L A +P Q   P         PL 
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKPKG---------LQALRPPQVTPPRKDAAPALGPLS 300

Query: 547 SSTL--------LRSPGSPQETVPEFP------CTFLPPTP-APTPPRPPPGPATLAPSR 591
           SS L        L+S   P  T+P  P      C    P P AP  P  PP   TL PS 
Sbjct: 301 SSPLATPSPSAALQSQAPP--TLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTL-PSP 357

Query: 592 PLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
           P   P     S  +P+     L    S +P P    +   PPQ
Sbjct: 358 PATPPSQATTSLGSPT-----LQATHSFLPSPPLSPLATPPPQ 395



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/234 (23%), Positives = 74/234 (31%), Gaps = 20/234 (8%)

Query: 417 PMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLP 476
           P A    LL   P  SPR P P  P A  V          P  +          P E  P
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP-ESAP 75

Query: 477 LGYSEPAFGPCFSMPRGKPPAPSPRGQKASP-------PTLAPATASPPTTAG------- 522
                 + G     P  +PPA S RG++A P       P  +P  AS  T  G       
Sbjct: 76  RAGPTRSAGTSSRNPASRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 523 ---SNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTP-P 578
              +         T A    AL       T   +PG+P   +             P P P
Sbjct: 135 RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 194

Query: 579 RPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP 632
              P P T  P + +        + P+P+   R  +G     P   +LS   +P
Sbjct: 195 SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 248


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  101 bits (252), Expect = 2e-21
 Identities = 113/357 (31%), Positives = 144/357 (40%), Gaps = 55/357 (15%)

Query: 325 PVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLP-EDPK 383
           P   SL SS T  P   PA S  +   G  R  A  S P P    A        P +D  
Sbjct: 228 PASRSLSSSAT--PLSSPARSGPS-ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 284

Query: 384 PRLPP---PPVPPPLLHYPP-PAKVPGLEPCPPPPFPPMAPPT------------ALLQE 427
           P L P    P+  P    PP P+  P L+  P PP  P +  T            + L  
Sbjct: 285 PALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPS 344

Query: 428 EPLFSPRFPFPTVPPAPGVSPL---PAPAAFPP-TPQSVPSP-APTPFPIELLPLGYSEP 482
            PL     P P  PPA  + PL   P+P A PP +P + PSP AP    + LL   +S P
Sbjct: 345 PPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 404

Query: 483 AFGPC---FSMPRGKPPAPSPRGQKASPPTLA--------PATASPPTTAGSNNPCLTQL 531
              P    FS P   P +PS      +PP+LA           ASPP +  +  P     
Sbjct: 405 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464

Query: 532 LTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTF-----------LPPTPAPTPPRP 580
             AA P Q  +PP  +   L +P  P + +P  P +F           LP +P  TP  P
Sbjct: 465 PLAAPPLQLAKPPPQAPPALATP--PLQALPSPPASFPGQAPFSPSASLPMSPLATP--P 520

Query: 581 PPGPATLAPSRPLL-VPKAERLSPPAPSGSERRLSGDLSSMPGPG-TLSVRVSPPQP 635
           P  P  LA   PLL VP +   SP   +       G  +S+ GP  TL++   PP P
Sbjct: 521 PQAPPVLA--APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP 575



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 116/401 (28%), Positives = 147/401 (36%), Gaps = 41/401 (10%)

Query: 264 PSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSF 323
           PSP   P   A      +  P  TP   +       +   T+S LP PP+      PP  
Sbjct: 298 PSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQA 357

Query: 324 SPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAF-------LSSDF 376
            P   +L       P  PPAS  ++ L+  S  QA N+    L  + F       + + F
Sbjct: 358 PP---ALALPPLQAPPSPPASPPLSPLATPSP-QAPNALAVHLLQAPFSPPPSPPVQAPF 413

Query: 377 LLPEDP--KPRLPPPPVPPPLLHYPP------PAKVPGLEP--CPPPPFPP--MAPPTAL 424
             P  P   P   PP   PP L  PP      P   P + P   PPP  PP   APP  L
Sbjct: 414 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQL 473

Query: 425 LQEEPLFSPRFPFPTV-----PPA--PGVSPLPAPAAFPPTPQSVPSP-APTPFPIELLP 476
            +  P   P    P +     PPA  PG +P    A+ P +P + P P AP      LL 
Sbjct: 474 AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ 533

Query: 477 LGYSEPAFGPCFSMPRGKPPAPSPRGQKASPP-TLAPATASPPTTAGSNNPCLTQLLTAA 535
           +  S PA  P    PR +PP P P    + P  TLA A   PP  + S +  L+    A 
Sbjct: 534 VPPSPPA-SPTLQAPR-RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG 591

Query: 536 KPEQALEPPLVSSTLLRSP--GSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPL 593
               A   P         P  G+     P+       P      P PP      AP  PL
Sbjct: 592 HSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA-FRGAPGAPL 650

Query: 594 LVPKAERLSPPAPSG--SERRLSGDLSSMPGPGTLSVRVSP 632
             P A    P +  G  +     G  S+ P PG L    SP
Sbjct: 651 PWPPA--TGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 114/393 (29%), Positives = 138/393 (35%), Gaps = 81/393 (20%)

Query: 265 SPLQLPPEDAYVGNADMIQPDLTPLQ--PSLDDFMDISDFFTNSRLPQPP-------MPS 315
           SPL  PP  A    A      L PLQ  PS      +S   T S  PQ P       + +
Sbjct: 348 SPLATPPPQAPPALA------LPPLQAPPSPPASPPLSPLATPS--PQAPNALAVHLLQA 399

Query: 316 NFPEPPSFSPVVDSLFS---SGTLGPEVPPASSAMTHLSGHSRLQARNSCPG--PLDSSA 370
            F  PPS  P V + FS   S  + P   P S A   L+    LQ   S P   P+  SA
Sbjct: 400 PFSPPPS--PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPP-LQVPPSPPASPPMSPSA 456

Query: 371 FLSSDFLLPEDPKPRLPPPPVPPPL-LHYPPPAKVPGLE-------PCPPPPFPPMAP-- 420
                      P P+ PPP   PPL L  PPP   P L        P PP  FP  AP  
Sbjct: 457 ----------TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 506

Query: 421 PTALLQEEPLFSP--------RFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPI 472
           P+A L   PL +P          P   VPP+P  SP       PPTP    S +     +
Sbjct: 507 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 566

Query: 473 ELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLL 532
            L P                G PP PS   +  S     P  A   ++A S    L    
Sbjct: 567 ALAP----------------GPPPPPS---RSPSSTLSGPDLAGHSSSATSTPEELRGYD 607

Query: 533 TAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
           +  +   A  PP  +      P +     P  P  F     AP P  P  GP +      
Sbjct: 608 SGPEGGAAASPPPDAELAACHPAA-WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 666

Query: 593 LLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
           +   +    + PAP        G L   P PGT
Sbjct: 667 IYETEGPESATPAP--------GALDPGPSPGT 691



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 86/333 (25%), Positives = 103/333 (30%), Gaps = 77/333 (23%)

Query: 377 LLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPP----------PPFPPMAPPTALLQ 426
           L P  P    PPPPV P  L     A   G +P             P   P A PT    
Sbjct: 25  LTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTR--T 82

Query: 427 EEPLFSPRF----PFPTVPPAPGVSPLPAPAAFPPTP-----------QSVPSPAPTPFP 471
             P  S R     P     P P  SP  A     P P           ++V     T  P
Sbjct: 83  SRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAP 142

Query: 472 -IELLPLGYSEPAFGPCFSMP------------------------RGKPPAPSPRGQKAS 506
               L  G      GP    P                        R +PP   PR   +S
Sbjct: 143 KRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSS 202

Query: 507 P---PTLAPATAS---PPTTAGSNNPCLTQLLTAAKP--EQALEPPLVSSTLLRSPGSPQ 558
                T  P+ A+   P    G   P    L ++A P    A   P    T  R+P  P 
Sbjct: 203 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT-PRAPAHPS 261

Query: 559 ETVPEFPCTFLPPTPAPTPPRPPPGPATLAP--SRPLLVPKAERLSPPAPSGSERRLSGD 616
           +  P+      P  P  TPPR    PA L P  S PL  P     +PP+PS         
Sbjct: 262 QPKPKGLQALRP--PQVTPPRKDAAPA-LGPLSSSPLATPSPS--APPSPSAPP-----S 311

Query: 617 LSSMPGPGTLSVRVSPPQPILSRGRPDSNKTEN 649
           L ++P P        P Q   S G P    T +
Sbjct: 312 LQTLPSPPA----TPPSQATTSLGSPTLQATHS 340



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 56/234 (23%), Positives = 74/234 (31%), Gaps = 29/234 (12%)

Query: 417 PMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLP 476
           P A    LL   P  SPR P P  P A  V          P  +          P     
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIP----- 71

Query: 477 LGYSEPAFGPCFSMPRGKPPAPSPRGQKASP-------PTLAPATASPPTTAG------- 522
              S P  GP  +    +PPA S RG++A P       P  +P  AS  T  G       
Sbjct: 72  --ESAPRAGPTRT---SRPPA-SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 125

Query: 523 ---SNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTP-P 578
              +         T A    AL       T   +PG+P   +             P P P
Sbjct: 126 RISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAP 185

Query: 579 RPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP 632
              P P T  P + +        + P+P+   R  +G     P   +LS   +P
Sbjct: 186 SARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATP 239


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 124/420 (29%), Positives = 149/420 (35%), Gaps = 66/420 (15%)

Query: 268  QLPPEDAYVGNADMIQPDLTPLQPSLDDFM-----DISDFFTNSRLPQPPMPSNFPEPPS 322
            Q PP  + + +A   QP   P      +F       +S  F NS         N P PP 
Sbjct: 809  QPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNS--------CNIPSPPP 860

Query: 323  FSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDP 382
              P  +S  S   LG  VPP    +  ++  +        P PL  +  L      P  P
Sbjct: 861  L-PCTESSSSMPGLGM-VPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPP----PPPP 914

Query: 383  KPRL---PPPPVP-------PPL--LHYPPPAKVPGLEPCPPPPFP----PMAPP---TA 423
             P     PPPP+P       PPL     PPP  +PG    PPPP P    P+ PP     
Sbjct: 915  LPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAG 974

Query: 424  LLQEEPLFSPRFPFPTVPPAPGVS---PLPAPAAFPPTPQSVPS---PAPTPFPIELLPL 477
            +    PL  P    P  PP PG     P P P A  P P  +P    P P P P   +P 
Sbjct: 975  IPPPPPL--PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1032

Query: 478  GYSEPAFG--PCFSMP-RGKPPAPSPRGQKASPPTLAPATA--SPPTTAGSNNPCLTQLL 532
                P  G  P   +P  G PP P   G    PP   P      PP   G+  P    L 
Sbjct: 1033 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP 1092

Query: 533  TAAKPEQALEPPLVSSTLLRSPGSPQETV---PEFPCTFLPPTPAPTP----PRPPPGPA 585
             A  P     PPL    +   P  P   +   P  P   +PP P P P    P PPP P 
Sbjct: 1093 GAGIPP---PPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPP-PPPLPGAGIPPPPPLPR 1148

Query: 586  TLAPSRPLLVPKAERLSPPAPSGS---ERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRP 642
               P  P L        PP P         L G +   P P    V + PP P+   G P
Sbjct: 1149 VGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-VGIPPPPPLPGVGIPPPPPLPGAGIP 1207



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 110/355 (30%), Positives = 124/355 (34%), Gaps = 70/355 (19%)

Query: 308  LPQPPMP-SNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPL 366
            LP PP+P +  P PP            G   P  PP   A   L     L      P P 
Sbjct: 932  LPLPPLPGAGIPPPPPLP---------GAAIPPPPPLPGAGIPLP--PPLPGAGIPPPPP 980

Query: 367  DSSAFLSSDFLLPE---DPKPRLP----PPPVPPPLLHYPPPAKVPGLEPCPPPPFP--- 416
               A +     LP     P P LP    PPP P P    PPP  +PG    PPPP P   
Sbjct: 981  LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 1040

Query: 417  ----PMAPPTALLQEEPLFSPRFPFPTVPPAPGVS---PLPAPAAFPPTPQSVPS---PA 466
                P  P   +    PL  P    P  PP PG     P P P A  P P  +P    P 
Sbjct: 1041 IPPPPPLPGAGIPPPPPL--PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1098

Query: 467  PTPFPIELLPLGYSEPAFG--PCFSMP-RGKPPAPSPRGQKASPPTLAPATA--SPPTTA 521
            P P P   +P     P  G  P   +P  G PP P   G    PP   P      PP   
Sbjct: 1099 PPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158

Query: 522  GSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPE---FPCTFLPPTP----- 573
            G+  P    L  A  P     PPL    +   P  P   +P     P   +PP P     
Sbjct: 1159 GAGIPPPPPLPGAGIPPP---PPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM 1215

Query: 574  ----APTPPRPPPG-----PATLAPSRPLLVPKAER-----------LSPPAPSG 608
                AP PP PPPG     P  L  S P L+P+              L PP PSG
Sbjct: 1216 GIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSG 1270



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 59/196 (30%), Positives = 68/196 (34%), Gaps = 46/196 (23%)

Query: 309  PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDS 368
            P PP+P     PP   P V         G  +PP                    P PL  
Sbjct: 1131 PPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPP--------------------PPPLPG 1170

Query: 369  SAFLSSDFLLPEDPKPRLP----PPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTAL 424
            +            P P LP    PPP P P +  PPP  +PG    PPPP P M  P A 
Sbjct: 1171 AGI---------PPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPA- 1220

Query: 425  LQEEPLFSPRFPFPTVPPAPGVSPLP-APAAFPP-TPQSVPSPAPTPFPIELLPLGYSEP 482
                    P  P P  PP  G+ P P  P + PP  PQ   S  PTP     LP      
Sbjct: 1221 --------PAPPLP--PPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSG 1270

Query: 483  AFGPCFSMPRGKPPAP 498
             FG   +  +G    P
Sbjct: 1271 LFGLGMNQDKGSRKQP 1286



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 72/263 (27%), Positives = 87/263 (33%), Gaps = 33/263 (12%)

Query: 395 LLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLF-SPR---FPFPTVPPAPGVS-PL 449
           +L  PP   +PG  PCPP       P T    E  L  SPR       +  P   +S P 
Sbjct: 754 VLTLPPVDGLPGRPPCPPG--AESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPP 811

Query: 450 PAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP-PAPSPRGQKASP- 507
           P P+      Q  P   P P  I        E +    F      P P P P  + +S  
Sbjct: 812 PPPSLLWSAGQGQPGSQP-PHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSM 870

Query: 508 PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPG--------SPQE 559
           P L      PP   G   P L    + A P+    PPL  + +L  P          P  
Sbjct: 871 PGLGMVPPPPPPLPGMTVPTLP---STAIPQ---PPPLQGTEMLPPPPPPLPGAGIPPPP 924

Query: 560 TVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSS 619
            +P      LPP P    P PPP P    P  P L      L PP P             
Sbjct: 925 PLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGA---------GI 975

Query: 620 MPGPGTLSVRVSPPQPILSRGRP 642
            P P      + PP P+   G P
Sbjct: 976 PPPPPLPGAGIPPPPPLPGAGIP 998


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 117/399 (29%), Positives = 155/399 (38%), Gaps = 35/399 (8%)

Query: 226  VPVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPD 285
            VP  L  P   P    + + +   S +S T+ ++  S   P+ +P       +A +  P 
Sbjct: 1403 VPSSLPGPASSP--MPIPNSSPLASPVSSTV-SVPLSSSLPISVPTTLPAPASAPLTIPI 1459

Query: 286  LTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSG-TLGPEVPPAS 344
              PL  S           T+   P  P+    P PPS +P   S  +S  TLG    P+ 
Sbjct: 1460 SAPLTVSASG----PALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSL 1515

Query: 345  SAMTHLSGHSRLQARNSC--PGPLDSSAFLSSDFLLPED----PKPRLPPPPVPPPLLHY 398
            S+ +   GH  L A  S   PG   + A   S  L+P      P P  P P      L  
Sbjct: 1516 SS-SQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLA 1574

Query: 399  PPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPT 458
            P  +    L     P  P  AP TA+L   P   P  P P + P+PG +P+ A +   P 
Sbjct: 1575 PASSASQALAT---PLAPMAAPQTAILAPSPA-PPLAPLPVLAPSPGAAPVLASSQ-TPV 1629

Query: 459  PQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPP 518
            P   PS  P        P+    P   P  +      P PSP    AS  TLA A A  P
Sbjct: 1630 PVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAP 1689

Query: 519  TTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGS-----PQETVPEFPCTFLPPTP 573
            T  GS +P  T  L    P    + P  + TL  +P S     P +T+   P   L PT 
Sbjct: 1690 TLGGS-SPSQTLSLGTGNP----QGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQ 1744

Query: 574  ----APTPPRPPPGPATLAPSRPL-LVPKAERLSPPAPS 607
                AP PP  P  P   AP+  L L P +   S  AP+
Sbjct: 1745 TLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPA 1783



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 107/397 (26%), Positives = 141/397 (35%), Gaps = 59/397 (14%)

Query: 282  IQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSN---FPEPPSFSPVVDSLFSSGTLGP 338
            + P   P    L   ++     T  RLP P + +     P P    P++  + S     P
Sbjct: 1327 LAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPS---P 1383

Query: 339  EVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFL--SSDFLLPEDPKPRLP-----PPPV 391
            EV  ++     L+  S L   +S PGP  S   +  SS    P      +P     P  V
Sbjct: 1384 EVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISV 1443

Query: 392  PPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPP-------AP 444
            P  L   P PA  P   P   P     + P  L    P  +P  P    PP       +P
Sbjct: 1444 PTTL---PAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP 1500

Query: 445  GVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP---PAPSPR 501
              S L    A  P+  S  +P     P+ L P     P      + P   P   PA +  
Sbjct: 1501 SASALTLGLATAPSLSSSQTPG---HPLLLAPTSSHVPGLNSTVA-PACSPVLVPASALA 1556

Query: 502  GQKASPPTLAPATASPPTTAGSNNPCL-TQLLTAAKPEQAL-----EPPLVSSTLLR-SP 554
                S P  APA AS    A S +  L T L   A P+ A+      PPL    +L  SP
Sbjct: 1557 SPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSP 1616

Query: 555  G------SPQETVPEFPCTFLP--------PTPAPTPPRPPPGPATLAPS---RPLLVPK 597
            G      S Q  VP    +  P        P PAPTP   P    T+ P+    PL  P 
Sbjct: 1617 GAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPA 1676

Query: 598  AERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
            + +    AP+     L+  L       TLS+    PQ
Sbjct: 1677 STQTLALAPA-----LAPTLGGSSPSQTLSLGTGNPQ 1708



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 85/299 (28%), Positives = 111/299 (37%), Gaps = 43/299 (14%)

Query: 309  PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDS 368
            P  P+P   P P + +PV   L SS T  P + P+S+  T L+  S +      P P   
Sbjct: 1605 PLAPLPVLAPSPGA-APV---LASSQTPVPVMAPSSTPGTSLASASPV------PAPTPV 1654

Query: 369  SAFLSSDFLLPEDPKPRLPPP---------PVPPPLLHYPPPAKVPGLEPCPPP-PFPP- 417
             A  S+  +LP      LP P         P   P L    P++   L    P  PFP  
Sbjct: 1655 LAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQ 1714

Query: 418  ---MAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIEL 474
               + P ++L+          P P + P   +S  PAP   P +P   P+PA T   + L
Sbjct: 1715 TLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVG-PAPAHT---LTL 1770

Query: 475  LPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTA 534
             P   S     P         PAP P    A+  TLA A AS  + A   +  +     A
Sbjct: 1771 APASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGA 1830

Query: 535  AK---------PEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGP 584
            A          P    EP  +  TL   P SP  T   F      P P   PP PP  P
Sbjct: 1831 APLPVTMVSRLPVSKDEPDTL--TLRSGPPSPPSTATSFG----GPRPRRQPPPPPRSP 1883



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 94/353 (26%), Positives = 132/353 (37%), Gaps = 78/353 (22%)

Query: 356  LQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPP---PPVPPPLLHYPPPAKV-------P 405
            +QA    PGP   S   SS       P     P     VPP +++     K+        
Sbjct: 1260 IQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRD 1319

Query: 406  GLEPCPP---PPFPPMAPPTALLQEEPLFSP-RFPFPTVPPAPGVSPLPAPAAFPPTPQS 461
            GL P PP    P PP +   A+L   P  +P R P PT+  A   +P+P P    P  + 
Sbjct: 1320 GLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTAR--APMPTPTLVRPLLKL 1377

Query: 462  VPSPAP--TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS--- 516
            V SP+P  +       PL  S P   P  S+P    PA SP     S P  +P +++   
Sbjct: 1378 VHSPSPEVSASAPGAAPLTISSPLHVPS-SLPG---PASSPMPIPNSSPLASPVSSTVSV 1433

Query: 517  ----------PPTTAGSNNPCLTQLLTAAKPEQALEPPLVSS-------TLLRSPGSPQ- 558
                      P T     +  LT  ++A     A  P L++S        +  +PG P  
Sbjct: 1434 PLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSL 1493

Query: 559  ----------------ETVPEFPCTFLPPTP---APTPPRPPPGPATLAPS-RPLLVPKA 598
                             T P    +  P  P   APT    P   +T+AP+  P+LVP +
Sbjct: 1494 APSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPAS 1553

Query: 599  ERLSP------PAP---------SGSERRLSGDLSSMPGPGTLSVRVSPPQPI 636
               SP      PAP         S + + L+  L+ M  P T  +  SP  P+
Sbjct: 1554 ALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPL 1606



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 85/316 (26%), Positives = 113/316 (35%), Gaps = 59/316 (18%)

Query: 382  PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVP 441
            P P L   P P P+    P + +    P  PP  P   PP  +L   PL       P V 
Sbjct: 1028 PGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLL-PPLQPNSGSLPQVL 1086

Query: 442  PAP-----GVSPLPAPA-AFPPTPQSVP--SPAPTPFPIELL-----PLGYSEP------ 482
            P+P     G S  P P  +  PTP +    SPAP P    LL     P GY+ P      
Sbjct: 1087 PSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATT 1146

Query: 483  -----AFGPCFSMPRGKPPAPS------------PRGQKASPPTLAPATASPPTTAGSNN 525
                 A     ++P    PAP             P G+  S   LA     P   AG + 
Sbjct: 1147 TSTTTATATTTAVP-APTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSK 1205

Query: 526  PCLTQL------LTAAKPEQAL--EP-PLVSSTL-LRSPGSPQETVPEFPCTFL----PP 571
            P   Q+      LT A+  Q    +P PL  + + L S G     + +     L     P
Sbjct: 1206 PLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAP 1265

Query: 572  TPAPTPPR--PPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVR 629
            TP PTP    P   P+T      L +P A    PP    +   +   +   P  G     
Sbjct: 1266 TPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDG----- 1320

Query: 630  VSPPQPILSRGRPDSN 645
            ++P  P+    RP S+
Sbjct: 1321 LTPVPPLAPAPRPPSS 1336



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 95/370 (25%), Positives = 128/370 (34%), Gaps = 88/370 (23%)

Query: 384  PRLPPPPVPPPLLHYPPPAKVPGLEPCP-PPPFPPMAP-PTALLQEEPLFSPRFPFPTVP 441
            PR  P P P P      PA +P L P P   P P  AP P  +L       P    P+ P
Sbjct: 2437 PRPAPRPRPTPA---SAPAAIPALVPVPVSAPVPISAPNPITIL-------PVHILPSPP 2486

Query: 442  PAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPR 501
            P   + P  +PA  PP P   P PA TP P +   +  S P      S+P        P 
Sbjct: 2487 PPSQIPPCSSPACTPP-PACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPL 2545

Query: 502  GQKASPPTLAPATASP-----PTTAGSNN------------PCLTQLLTAAKPEQALEPP 544
            G +      A A ASP      + A S              P   ++L  ++   +L P 
Sbjct: 2546 GLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPS 2605

Query: 545  LVSSTL----------LRSPGSPQET--------------VPEFPCTFLPPTPAPTPPRP 580
              S TL            +P S + T              V E     LPP+ A   P  
Sbjct: 2606 APSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQ 2665

Query: 581  PPGPA-------------TLAPSRPLLVPKAERLSP------------PAPSGSERRLSG 615
             P  A             T +P +P  +  AE  +P            P+P+   RR + 
Sbjct: 2666 EPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTS 2725

Query: 616  DLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQ--KRRFNIKLGFDTLH 673
                + G GT      PP P + R      K   R +T +  ++  +RR   +    TL 
Sbjct: 2726 ADVEIRGQGT-GRPGQPPGPKVLR------KLPGRLVTVVEEKELVRRRRQQRGAASTLV 2778

Query: 674  GLVSTLSAQP 683
              VS  SA P
Sbjct: 2779 PGVSETSASP 2788



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 57/217 (26%), Positives = 77/217 (35%), Gaps = 37/217 (17%)

Query: 409  PCPPP-PFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAP 467
            P PPP P P       +LQ  P    R       P   + P+P     PP P+    P P
Sbjct: 981  PDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRP--PPGPELSAQPTP 1038

Query: 468  TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPC 527
             P P ++LP      A               SP G     P L PA+  P          
Sbjct: 1039 GPVP-QVLPASLMVSA---------------SPAG-----PPLIPASRPPGPV------- 1070

Query: 528  LTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATL 587
               LL   +P     P ++ S L    G+ +   P       PP P    P PPPG ++L
Sbjct: 1071 ---LLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSL 1127

Query: 588  APSRPLLVPKAERLSP-PAPSGSERRLSGDLSSMPGP 623
               +PL VP      P  A + S    +   +++P P
Sbjct: 1128 L--KPLTVPPGYTFPPAAATTTSTTTATATTTAVPAP 1162



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 106/411 (25%), Positives = 137/411 (33%), Gaps = 95/411 (23%)

Query: 307  RLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPL 366
            R+P+P  P   P P S    + +L       P    A + +T L  H         P P 
Sbjct: 2435 RVPRPA-PRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHI-------LPSPP 2486

Query: 367  DSSAFLSSDFLLPEDPKPRLPPPPV-PPPLLHYPPPAKVPGLEPCPPPPF-PPMAPPTAL 424
              S        +P    P   PPP   PP  H PPPA+   + P  P    PP  P +A 
Sbjct: 2487 PPSQ-------IPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISAS 2539

Query: 425  LQEEPL-FSPRFPFPTVPPAPGVSPLPAPAAFPPTPQS--VPSPAPTPFPIELLPLGYSE 481
            +   PL   P         A   S   A  A   T     VP     P  +E+LP+    
Sbjct: 2540 VTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKN 2599

Query: 482  PAFGPCFSMPRGKPPAPS-PRGQKASPPTLAPATASPPTTAGSNNP-CLTQ-----LLTA 534
             +  P  S P     A S P GQ+   P  A  T       G   P C+++     L  +
Sbjct: 2600 LSLTP--SAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPS 2657

Query: 535  AKPEQALEPPLVSS----------TLLRSPGSPQETVPE---FPCTFLPPTPAPTPPRP- 580
            A  ++ L+ PL +           T   SP  PQE V      P T    T +P  P P 
Sbjct: 2658 AASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPA 2717

Query: 581  -----------------------PPGPATLA--PSRPL---------------------L 594
                                   PPGP  L   P R +                     L
Sbjct: 2718 RPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTL 2777

Query: 595  VPKAERLSPPAPSGSERRLSGDLSSMP--GP----GTLSVRVSPPQPILSR 639
            VP     S    S S R +SG  SS P  GP     + S+   P QP ++R
Sbjct: 2778 VPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIAR 2828



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 67/268 (25%), Positives = 97/268 (36%), Gaps = 63/268 (23%)

Query: 384  PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA 443
            PR P  PVP      PPP      +P P P  P + P + ++   P   P  P       
Sbjct: 1015 PRAPLGPVPVR----PPPGPELSAQPTPGP-VPQVLPASLMVSASPAGPPLIP------- 1062

Query: 444  PGVSPLPAPAAFPP-TPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRG 502
               S  P P   PP  P S   P   P P+ +L                  +PP P+   
Sbjct: 1063 --ASRPPGPVLLPPLQPNSGSLPQVLPSPLGVL--------------SGTSRPPTPT-LS 1105

Query: 503  QKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVP 562
             K +PP  AP   SP    GS++  L + LT   P     PP  ++T   +  +   T  
Sbjct: 1106 LKPTPP--APVRLSPAPPPGSSS--LLKPLTV--PPGYTFPPAAATTTSTTTATATTTA- 1158

Query: 563  EFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLS----------PPAPSGSER- 611
                      PAPT   P P    L+P     +P  E +S          P A +G  + 
Sbjct: 1159 ---------VPAPT---PAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKP 1206

Query: 612  ---RLSGDLSSMPGPGTLSVRVSPPQPI 636
               ++ G+  ++ G     + V  P+P+
Sbjct: 1207 LTFQIQGNKLTLTGAQVRQLAVGQPRPL 1234



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 55/218 (25%), Positives = 75/218 (34%), Gaps = 61/218 (27%)

Query: 441  PPAPGVSPLPAPAAFPPT--------PQSVPSPAPTPF----PIELLPLGYSEPAFG--- 485
            P +P V  +  P + PP           S+P+P   PF     IEL   G   P  G   
Sbjct: 2788 PGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGA 2847

Query: 486  ------PCFSMPRGKPP----APSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAA 535
                  P     RG+PP    +P+  G+       AP++     T G++     + L  A
Sbjct: 2848 LLAITPPAVKRRRGRPPKKNRSPADAGRGVDE---APSSTLKGKTNGADPVPGPETLIVA 2904

Query: 536  KPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLV 595
             P   LEP L+                        P P P  P+P   P       PLL 
Sbjct: 2905 DP--VLEPQLI------------------------PGPQPLGPQPVHRP------NPLLS 2932

Query: 596  PKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPP 633
            P  +R     P   +  + G +SS  G G    R  PP
Sbjct: 2933 PVEKRRRGRPPKARDLPIPGTISS-AGDGNSESRTQPP 2969



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 36/119 (30%), Positives = 43/119 (36%), Gaps = 15/119 (12%)

Query: 403  KVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPL-PAPAAFPPTPQS 461
            K  G +P P P    +A P    Q  P   P  P P   P P +SP+       PP  + 
Sbjct: 2888 KTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARD 2947

Query: 462  VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTT 520
            +P P      I     G SE    P        PP PSP      PP L   TA+   T
Sbjct: 2948 LPIPG----TISSAGDGNSESRTQP--------PPHPSP--LTPLPPLLVCPTATVANT 2992


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 122/417 (29%), Positives = 151/417 (36%), Gaps = 82/417 (19%)

Query: 272 EDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSR----LPQPPMPSNFPEPPSFSPVV 327
           E++     + +    T L P L     I   +T S+    LP PP P   P PP   P  
Sbjct: 588 EESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPP 647

Query: 328 ----DSLFSSGTLGPEVPPASSA--MTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPED 381
                S  S+G+  P     S+   + + S HS    +   P  + S +      + P  
Sbjct: 648 PLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNG 707

Query: 382 PKPRLPPPPVPP---------------PLLHY----PPPAKV----------PGLEPCPP 412
             P  PPPP PP               P L      PPP K+          P   P PP
Sbjct: 708 VVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPP 767

Query: 413 P---PFPPMAPPTALLQEEPLFSPRFPFPTV------PPAPGVSPLPAPAAFPPT--PQS 461
           P   P PP APP  L+      S +   P V       P P V P     AFP +  P S
Sbjct: 768 PIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS 827

Query: 462 VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKAS---PPTLAPATASPP 518
            P+P P P P   LP   S  A  P    P    P PS   Q AS   PP   PA  S P
Sbjct: 828 PPTP-PVPVPPPTLPKQQSFCAKPP----PSPLSPVPSVVKQIASQFPPPPTPPAMESQP 882

Query: 519 TTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
                 N    Q   A K +   +P   SS  + SP  P    PE    F PP P+P P 
Sbjct: 883 LKPVPAN-VAPQSPPAVKAKPKWQP---SSIPVPSPDFPPPP-PESSLVFPPPPPSPVPA 937

Query: 579 RPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
            PPP P T +P+             P  SGS  + +   SS  G      +  PP P
Sbjct: 938 PPPPPPPTASPT-------------PDKSGSPGKKTSKTSSPGG------KKPPPTP 975



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 81/293 (27%), Positives = 105/293 (35%), Gaps = 52/293 (17%)

Query: 382 PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTA--------------LLQE 427
           P P LPPPP PPP    PPP   P     PPPP P  + P+A               LQ 
Sbjct: 624 PSPPLPPPPPPPP----PPPPPPPP----PPPPLPSQSAPSAGSAAPMFVKYSTITRLQN 675

Query: 428 EPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPC 487
               S     P  PP      +      PP     P P P P P     +   +PA  PC
Sbjct: 676 ASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPA--PC 733

Query: 488 F-SMPRGKPPAP-------------SPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLT 533
             S+P+   P P             +P      PP  AP     P       P  T   T
Sbjct: 734 APSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKT 793

Query: 534 AAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPL 593
            A       PP  +      P  P +  P FP +++PP+P PTPP P P P    P +  
Sbjct: 794 VAPVVTQAAPPTPT-----PPVPPAKKQPAFPASYIPPSP-PTPPVPVPPPT--LPKQQS 845

Query: 594 LVPKAERLSPPAPSGSERRLSGDLSSM--PGPGTLSVRVSPPQPILSRGRPDS 644
              K     PP+P      +   ++S   P P   ++   P +P+ +   P S
Sbjct: 846 FCAK----PPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVPANVAPQS 894



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 89/336 (26%), Positives = 116/336 (34%), Gaps = 82/336 (24%)

Query: 266  PLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSP 325
            P+ +PP       +   +P  +PL P       I+     S+ P PP P      P   P
Sbjct: 832  PVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIA-----SQFPPPPTPPAMESQP-LKP 885

Query: 326  VVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPR 385
            V         + P+ PPA  A       S                       +P  P P 
Sbjct: 886  V------PANVAPQSPPAVKAKPKWQPSS-----------------------IPV-PSPD 915

Query: 386  LPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPG 445
             PPPP    L+  PPP   P   P PPPP     PPTA    +   SP           G
Sbjct: 916  FPPPPPESSLVFPPPP---PSPVPAPPPP----PPPTASPTPDKSGSPGKKTSKTSSPGG 968

Query: 446  VSPLPAPAAFPPTPQ---SVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRG 502
              P       PPTPQ   S+ S +    P    P   S         + +  PPA S   
Sbjct: 969  KKP-------PPTPQRNSSIKSSSGAEHPEPKRPSVDS--------LVSKFTPPAESGSP 1013

Query: 503  QKAS-PPTLAPATASPPTTAGSNNP-CLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQET 560
             K + PP  AP        +G N P  L Q   +AK       P++S       G  +++
Sbjct: 1014 SKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAK------APVLS-------GRGKDS 1060

Query: 561  VPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVP 596
            V EF      P+P      PPP P T  P  P+ +P
Sbjct: 1061 VVEF------PSPPSDSDFPPPPPETELPLPPIEIP 1090



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 63/253 (24%), Positives = 78/253 (30%), Gaps = 58/253 (22%)

Query: 309  PQPPMPSNFPEPPSFSPVVDSLF-SSGTLGPEVPPASSAMTHLSGHSR----LQARNSCP 363
            P+P  PS       F+P  +S   S  TL P   P      +LSG +      Q   S  
Sbjct: 990  PEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAK 1049

Query: 364  GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPP---PAKVPG-------------- 406
             P+ S     S    P  P     PPP P   L  PP   PA   G              
Sbjct: 1050 APVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQ 1109

Query: 407  ------LEPCPPPPFPPMAPPTALLQEEPLFSPRFP--FPTVPPAPGVSPLPAPAAFPPT 458
                  ++  PPP  P     T L Q E    P      P VP +P  S    P      
Sbjct: 1110 QWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADL 1169

Query: 459  PQSVPSPAPT------------------------PFPIELLP----LGYSEPAFGPCFSM 490
             +++   + T                        P P ELL      GY         ++
Sbjct: 1170 NRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSHISGYATL 1229

Query: 491  PRGKPPAPSPRGQ 503
             RG PPAP  R Q
Sbjct: 1230 RRGPPPAPPKRDQ 1242


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 116/472 (24%), Positives = 161/472 (34%), Gaps = 83/472 (17%)

Query: 233  PEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPE-------DAYVGNADMIQPD 285
            P E+ G          L+ ++D+   +  S     + PP        D  +GN   +   
Sbjct: 771  PTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGN---LSSP 827

Query: 286  LTPLQPSLD-----DFMDISDFFTNSRLPQPPMPSNFPEPPSFSP--------------- 325
            ++P++ S        F    D    +  P PP P   P P + +P               
Sbjct: 828  VSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPT 887

Query: 326  --VVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPE--D 381
              VV+  F         P  + A++  S   +       P  + +S         P    
Sbjct: 888  PSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATP 947

Query: 382  PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP-PTALLQEEPLFSPRFPFPT- 439
            P P+  P    P     PP A  P  +  P  P P  AP P A     P   P  P P  
Sbjct: 948  PSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007

Query: 440  --VPPA---------PGVSPLPA-----PAAFPPTPQSVPSPAPTPFPIELLPLG-YSEP 482
               PPA         P  +P P      PAA PP+P+  P+  P P      P      P
Sbjct: 1008 APTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSP 1067

Query: 483  AFGPCFSM--------------PRGKPPAPSPRGQK----ASPPTLAPATASPPTTAGSN 524
              GP                  P+G P  PSP+G      A+PP+     A+PP      
Sbjct: 1068 KGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPT 1127

Query: 525  NPCLTQLLTAAKPEQALEPPL-VSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPG 583
             P  T    + K   A  PP    +T   +P SP+  +   P    P TPA TPP P  G
Sbjct: 1128 TPAATP--PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1185

Query: 584  PATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
             AT +P      P A   +PP+P G      G  +  P     +   +PP P
Sbjct: 1186 LATPSPKGAPTTPAA---TPPSPKG------GLATPSPKGAPTTPAATPPSP 1228



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 103/341 (30%), Positives = 134/341 (39%), Gaps = 72/341 (21%)

Query: 334  GTLGPEVPPA--SSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPP- 390
            G+ GP+ P    SS ++ +      +   S  G  DS A   S    P  P P+  P P 
Sbjct: 813  GSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHS----PTPPSPKGAPTPS 868

Query: 391  -----------VPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
                       +PP     P    +P  +  P  P P  AP  ++    P  +   P P 
Sbjct: 869  AVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPK 928

Query: 440  ---VPPAPGVSPLPAPAAFPPTPQ---SVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRG 493
                 P+P  +P P PAA PP+P+   + PSP   P P    P     P  GP    P+G
Sbjct: 929  GIPASPSPKGAPTP-PAATPPSPKGGPATPSPKWAPTPPAATP---PSPKGGPATPSPKG 984

Query: 494  KP--PA---PSPRGQKASP-----PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEP 543
             P  PA   PSP+G  A+P     PT  P   +PP+  GS  P  T     A    A  P
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPT--PPAVTPPSPKGS--PAATPFPKGASTPPAATP 1040

Query: 544  PLVSSTLLRSP-GSPQET-VPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERL 601
            P        SP GSP  T +P+      P TPA T P P  GPAT +       P A   
Sbjct: 1041 P--------SPKGSPAATPLPKGA----PTTPAATLPSPKGGPATPSLKGAPTPPAA--- 1085

Query: 602  SPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRP 642
            +PP+P G             GP T S + +P  P  +   P
Sbjct: 1086 TPPSPKG-------------GPATPSPKGAPMPPAATPPSP 1113



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 97/370 (26%), Positives = 138/370 (37%), Gaps = 56/370 (15%)

Query: 309  PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDS 368
            P  P P   P PP+ +P   S   + TL P   P+S       G +   ++     P  +
Sbjct: 1324 PGTPPPKGAPTPPAVTP--PSPKGTPTL-PATTPSSKG-----GPTTPSSKEGPTPPAAT 1375

Query: 369  SAFLSSDFLLPEDPK--PRLPPP---PVPPPLLHYPP---PAKVPGLEPCPPPPFPPMAP 420
             +      + P  PK  P +P P   P  P ++   P   PA     E    P    + P
Sbjct: 1376 PSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP 1435

Query: 421  PTAL---LQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSP-------APTPF 470
            P      L++ P  S     P  P + G   LPA    PP+P+  P+P       +P   
Sbjct: 1436 PAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVT--PPSPKEPPAPKQVATSSSPKKA 1493

Query: 471  PIELLPLGYSE-PAFGPCFSMPRGKPPAPSPRGQ----------KASPPTLAPATASPPT 519
            P    P+G    PA  P  S P+  P  PS R            K +P TLAP  A  P 
Sbjct: 1494 PATPAPMGAPTLPAVIP--SSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551

Query: 520  TAGSNNPCLTQLLTAAKP-------EQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPT 572
                 +P  T  +   K        ++A  PP V+ +  +   SP+E +     T   P 
Sbjct: 1552 AMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPK 1611

Query: 573  PAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSP 632
             APTPP   P      P+ P   PK    SPP    S +       S   P +++ ++  
Sbjct: 1612 EAPTPPAVTPPSPEKGPATP--APKGTPTSPPVTPSSLK------DSPTSPASVTCKMGA 1663

Query: 633  PQPILSRGRP 642
              P  S+G P
Sbjct: 1664 TVPQASKGLP 1673



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 86/337 (25%), Positives = 116/337 (34%), Gaps = 68/337 (20%)

Query: 309  PQPPMPSNFPEPPSFSPVVDS--LFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPL 366
            P  P P   P PP+ +P      L +    G    PA++  +   G +    + +   P 
Sbjct: 1094 PATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPA 1153

Query: 367  DSSAFLSSDFLLPEDPKPRL--PPPPVPPPLLHYPPPAKVPGLEPCPP------PPFPPM 418
             +          P  PK  L  PPP   P      PP+   GL    P      P   P 
Sbjct: 1154 AT----------PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1203

Query: 419  APPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLG 478
            +P   L    P  +P  P  T P   G    P+P   P TP + P               
Sbjct: 1204 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP--------------- 1248

Query: 479  YSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPE 538
               P  GP    P+G P  P+     A+PP+L    A+PP   G+ NP +          
Sbjct: 1249 -PSPKGGPATPPPKGAPTPPA-----ATPPSLKGGLATPP-HKGAPNPAVV--------- 1292

Query: 539  QALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKA 598
                          +P SP+      P    P  PA TPP P   P T  P      P  
Sbjct: 1293 --------------TPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKG---APTP 1335

Query: 599  ERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
              ++PP+P G+    +   SS  GP T S +  P  P
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPP 1372



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 108/411 (26%), Positives = 144/411 (35%), Gaps = 75/411 (18%)

Query: 288  PLQPSLDDFMDISDFFTNSRLP------QPPMPSNFPEP-------PSFSPVVDSLFSSG 334
            PL P+  +   ++    N+  P       P +P + P P       P  +  VD +  + 
Sbjct: 699  PLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTS 758

Query: 335  TLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPP----- 389
             L P         T  SG S   A  S  G L   A   S   +   P+ + PP      
Sbjct: 759  ALAPVASSPKECPTEDSGAS---ATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSA 815

Query: 390  -----------PVPPPLLHYPPPAKV--------PGLEPCPPPPFPPMAP-PTALLQEEP 429
                       PV P    + P   +        P     P PP P  AP P+A+    P
Sbjct: 816  GPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSP 875

Query: 430  LFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFS 489
                  P  T  P P V  LP P   P TP    +PA        L +  S P       
Sbjct: 876  KGVTLPPKET--PTPSVVNLPFPKEGPATPAPKQAPA--------LSMTSSSPKKARATP 925

Query: 490  MPRGKPPAPSPRGQKASP------PTLAPATASP---PTTAGSNNPCLTQLLTAAKPEQA 540
             P+G P +PSP+G    P      P   PAT SP   PT   +  P          P+ A
Sbjct: 926  APKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGA 985

Query: 541  LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATL-----APSRPLLV 595
              PP  ++T     G P    P+      P  PA TPP P   PA       A + P   
Sbjct: 986  PTPP--AATPPSPKGGPATPSPKGA----PTPPAVTPPSPKGSPAATPFPKGASTPPAAT 1039

Query: 596  PKAERLSP---PAPSGSERRLSGDL-SSMPGPGTLSVRVSPPQPILSRGRP 642
            P + + SP   P P G+    +  L S   GP T S++ +P  P  +   P
Sbjct: 1040 PPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSP 1090



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 91/356 (25%), Positives = 129/356 (36%), Gaps = 34/356 (9%)

Query: 312  PMPSNFPEPPSFSPVVDS--LFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSS 369
            P P   P  P+ +P      L +    G    PA++  +   G +    + +   P  + 
Sbjct: 1212 PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP 1271

Query: 370  AFLSSDFLLPED---PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQ 426
              L      P     P P +  PP P       PP   P   P   PP P  +P T    
Sbjct: 1272 PSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP-TPPAATPPSPKGSPGTP--- 1327

Query: 427  EEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGP 486
              P  +P  P  T P   G   LPA         + PS    P P    P     PA  P
Sbjct: 1328 -PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTP 1386

Query: 487  CFSMPRGKPPAPSPRGQKASP------PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
                P+  P  PSP+G   SP      P  APAT  P T  G+  P    L   A    +
Sbjct: 1387 --PSPKRGPAIPSPKGDPTSPAVIPLSPKKAPAT--PVTREGAATPSKGDLTPPAVTPVS 1442

Query: 541  LEPPLVSSTLLRSPGSPQE----TVPEF--PCTFLPPTP-----APTPPRPPPGPATL-A 588
            L+    +S     P +P      T+P    P    PP P     + +P + P  PA + A
Sbjct: 1443 LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502

Query: 589  PSRPLLVPKAERLSPPAPSGSERRL--SGDLSSMPGPGTLSVRVSPPQPILSRGRP 642
            P+ P ++P + +  P  PS     +  +  L S   P TL+ + +   P ++   P
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSP 1558



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 103/437 (23%), Positives = 148/437 (33%), Gaps = 66/437 (15%)

Query: 264  PSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSF 323
            PSP + PP    V  +    P   P  P+      +     +S    P  PS+  +P + 
Sbjct: 1473 PSPKE-PPAPKQVATSS--SPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAP 1529

Query: 324  SPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPK 383
            +  + S  +  TL P+      AMT  S     +   + P P ++ A  SS        K
Sbjct: 1530 TATLLSKKTPATLAPKEALIPPAMTVPSP----KKTPAIPTPKEAPATPSS--------K 1577

Query: 384  PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAP-PTALLQEEPLFSPRFPFPT-VP 441
                PP V P      P  K   + P    P P  AP P A+    P   P  P P   P
Sbjct: 1578 EASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTP 1637

Query: 442  PAPGVSP---------------------------LPAPAAFPPTPQSVPSPAPTPFPIEL 474
             +P V+P                           LPA        + + +PAP   PI  
Sbjct: 1638 TSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIIT 1697

Query: 475  LPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASP-----PTTAGSNNPCLT 529
             P            + P   P   +  G K    T+APA   P       TA   +   +
Sbjct: 1698 APTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS 1757

Query: 530  QLLTAAKPEQALEPPLVSST---LLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP----- 581
                 A PE     PL ++    +L  P S   +    P   LP  P+P P  PP     
Sbjct: 1758 PKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFL 1817

Query: 582  ---PGPATLAPSRPLLVPKAER---LSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPP-- 633
               PG    +PS+PL     +    L PP P          L +MP P +  + V  P  
Sbjct: 1818 PSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSA 1877

Query: 634  -QPILSRGRPDSNKTEN 649
             QP+    +    ++++
Sbjct: 1878 KQPVTKNNKGSGTESDS 1894



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 63/237 (26%), Positives = 85/237 (35%), Gaps = 43/237 (18%)

Query: 436 PFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP 495
           P PT+PP       PAP   P +  +  SP P+P  I   PL    P      ++P G  
Sbjct: 41  PGPTLPPPCS----PAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTA 96

Query: 496 P-----APSPRGQKASPPTLAPATAS-PPTTAGSNNPCLTQLLTAAKPEQALEPPLVSST 549
           P      P+  G   SP  LA A+    PT  G+ +      L A  P    +       
Sbjct: 97  PEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPN 156

Query: 550 LLRSPGS------------PQETVPEFPCTFLPPTPAPTPPRP--PPGPATLAPSRP--L 593
           LL SP S                 P  P T L   P+   P P   P P  +  + P   
Sbjct: 157 LLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHC 216

Query: 594 LVPKAE---------------RLSPPAPSGSERRLSGDLSSMPGPGTLSVR--VSPP 633
           + P A                 L+  +P   +  +S  L S   PG+LS++  VSPP
Sbjct: 217 VTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPP 273



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 46/198 (23%), Positives = 70/198 (35%), Gaps = 13/198 (6%)

Query: 405 PGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPS 464
           P +   P     P +P   ++       P     T    P   PLP P      P SV  
Sbjct: 465 PPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLV 524

Query: 465 PAPTPFPIELLPLGYSEPAFGPC-FSMPRGKPPAPSPRGQKA--SPPTLAPATASP---- 517
             PT   ++ +P       F P    +   K P   P  Q A  + P+    ++SP    
Sbjct: 525 KFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPL 584

Query: 518 PTTAGSNNPCLTQLLTAAKPEQALEPPL---VSSTLLR--SPGSPQETVPEFPCTFLPPT 572
              A      L + L   KP  ++  PL    S+++++  S   P    P    + + PT
Sbjct: 585 SPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPT 644

Query: 573 PAPTPPRPPPGPATLAPS 590
            A   P     PA +AP+
Sbjct: 645 VAAF-PLESADPAGVAPT 661


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 114/395 (28%), Positives = 146/395 (36%), Gaps = 49/395 (12%)

Query: 258 TMTQSGPSPLQLPPEDAYVGNADM-IQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSN 316
           +M    P PLQ   E   +G A + ++P L   +  L++ M +      S L  PP  S 
Sbjct: 403 SMQPKEPGPLQC--EAKPLGKAGVQLEPQL---EAPLNEEMPLLPPPEESPLSPPPEESP 457

Query: 317 FPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDF 376
              PP  S +           PE  PAS     L     L+     P P +S        
Sbjct: 458 TSPPPEASRLSPP--------PEELPASPLPEALHLSRPLEESPLSPPPEES-------- 501

Query: 377 LLPEDPKPRLPP------PPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPL 430
             P  P P   P       P+ PP    P PA    L P  PP   P++PP    +E PL
Sbjct: 502 --PLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSP--PPEASPLSPP---FEESPL 554

Query: 431 FSPRFPFPTVPP--APGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCF 488
             P    PT PP  A  +SP P  +   P P+  P  +P P    L P     P   P  
Sbjct: 555 SPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPM-SPPPEASRLFPPFEESPLSPP-- 611

Query: 489 SMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSS 548
             P   P +P P   + SPP      + PP  +  + P     L+       L PP   S
Sbjct: 612 --PEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEES 669

Query: 549 TLLRSP-GSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLL-VPKAERLSPPAP 606
            L   P  SP    PE      PP  +PT P P   PA+  P   L+ +P  E    P P
Sbjct: 670 PLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLP 729

Query: 607 SGSE---RRLSGDLSSMPGPGTLSVRVSPPQPILS 638
              +   R     LS  P    LS R  P +P LS
Sbjct: 730 EEPQLCPRSEGPHLSPRPEEPHLSPR--PEEPHLS 762



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 129/480 (26%), Positives = 165/480 (34%), Gaps = 80/480 (16%)

Query: 191 RLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLS 250
           RL  P  E  +  P +     PPPE       S + P     P   P     L      S
Sbjct: 571 RLSPPPEESPMSPPPEESPMSPPPEA------SRLFPPFEESPLSPPPEESPLSPPPEAS 624

Query: 251 DISDTLFTMTQSGP---SPLQLPPEDAYVGNADMIQ-----PDLTPLQPSLDDFMDISDF 302
            +S        S P   SP+  PPE + +    ++      P+ +PL P  ++    S  
Sbjct: 625 RLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEE-SPTSPP 683

Query: 303 FTNSRLPQPPMPSNFPEPPSFSPVV----DSLFSSGTLGPEVPPASSAMTHLSGHSRLQA 358
              SRL  PP  S    PP  SP      DSL S       +P   S +  L    +L  
Sbjct: 684 PEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMS-------LPLEESPLLPLPEEPQLCP 736

Query: 359 RNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPM 418
           R+  P             L P   +P L P P  P   H  P A+ P L P P  P    
Sbjct: 737 RSEGP------------HLSPRPEEPHLSPRPEEP---HLSPQAEEPHLSPQPEEPCLCA 781

Query: 419 APPTALLQEEPLFSPRFPFPTVPPAPG---VSPLPAPAAFPPTPQSVPSPAPTPFPIELL 475
            P      EEP  SP+   P + P P    +SP        P P+  P  +P P    L 
Sbjct: 782 VP------EEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEE-PCLSPQPEESHLS 834

Query: 476 PLGYSEPAFGP----CFSMPRGKPPAPSPRGQKA-SPPTLAPATASPPTTAGSNNPCLTQ 530
           P    EP   P        P  + P  SPR +K    P   PA    P       P L+ 
Sbjct: 835 PQS-EEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSP 893

Query: 531 LLTAAKPEQALEPPL--VSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLA 588
           LL      +  EPPL  +   L  SP       P+     +PP P P    PP  P   A
Sbjct: 894 LLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQL----MPPDPLP----PPLSPIITA 945

Query: 589 PSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTE 648
            + P L P  E   P    G       D  S      L   +SPP        P++N T+
Sbjct: 946 AAPPALSPLGELEYPFGAKG-----DSDPESPLAAPILETPISPP--------PEANCTD 992



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 100/345 (28%), Positives = 126/345 (36%), Gaps = 48/345 (13%)

Query: 311 PPMPSNFP--EPPSFSPVVDSLFSSG---TLGPEVPPASSAMTHLSGHSRLQARNSCPGP 365
           PP P + P  EP +           G   ++ P+ P          G + +Q       P
Sbjct: 374 PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433

Query: 366 LDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTAL- 424
           L+    L    L P +  P  PPP   P      PP +   L P PP   P    P AL 
Sbjct: 434 LNEEMPL----LPPPEESPLSPPPEESPT----SPPPEASRLSP-PPEELPASPLPEALH 484

Query: 425 ----LQEEPLFSPRFPFPTVPPAPG--VSPLPAPAAFPPTPQSVPSPA---PTPFPIELL 475
               L+E PL  P    P  PP      SPL      PP  +S PSPA   P   P E  
Sbjct: 485 LSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPE-ESPPSPALETPLSPPPEAS 543

Query: 476 PLGYSEPAF--GPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLT 533
           PL    P F   P    P   P +P P   + SPP      + PP  +  + P     L 
Sbjct: 544 PLS---PPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLF 600

Query: 534 AAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAP---- 589
               E  L PP   S L   P + +          L P P  +P  PPP  + ++P    
Sbjct: 601 PPFEESPLSPPPEESPLSPPPEASR----------LSPPPEDSPMSPPPEESPMSPPPEV 650

Query: 590 SRPLLVPKAERLSPPAPSGSERRLSGDLSSMP-GPGTLSVRVSPP 633
           SR   +P   RLSPP     E  LS      P  P   + R+SPP
Sbjct: 651 SRLSPLPVVSRLSPPP---EESPLSPPPEESPTSPPPEASRLSPP 692



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 135/494 (27%), Positives = 179/494 (36%), Gaps = 79/494 (15%)

Query: 192 LRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVP--VLLGDP-EEEPGGRQLLDLNCF 248
           L  P  E     P +A    PPPE    +L +S +P  + L  P EE P      +    
Sbjct: 449 LSPPPEESPTSPPPEASRLSPPPE----ELPASPLPEALHLSRPLEESPLSPPPEESPLS 504

Query: 249 LSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRL 308
               S     + +S  SP +  P    +       P+ +PL P  ++   +S        
Sbjct: 505 PPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEE-SPLSPPPEELPT 563

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDS 368
             PP  S    PP  SP+              PP  S M+     SRL        P + 
Sbjct: 564 SPPPEASRLSPPPEESPM------------SPPPEESPMSPPPEASRLFP------PFEE 605

Query: 369 SAFLSSDFLLPEDPKP---RLPPPPVPPPLLHYPPPAKVPGLEPCPPP------PFPPMA 419
           S         P  P P   RL PPP   P+   PPP + P     PPP      P P ++
Sbjct: 606 SPLSPPPEESPLSPPPEASRLSPPPEDSPM--SPPPEESP---MSPPPEVSRLSPLPVVS 660

Query: 420 PPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTP-------FPI 472
             +   +E PL  P    PT PP       P P   P +P    SPA  P        P+
Sbjct: 661 RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL 720

Query: 473 E---LLPLGYSEPAF-----GPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSN 524
           E   LLPL   EP       GP  S PR + P  SPR ++   P L+P    P  +    
Sbjct: 721 EESPLLPLP-EEPQLCPRSEGPHLS-PRPEEPHLSPRPEE---PHLSPQAEEPHLSPQPE 775

Query: 525 NPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQ------ETVPEFPCTFLPPTPAPTPP 578
            PCL  +          E P +S        SPQ        VPE PC    P  +   P
Sbjct: 776 EPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSP 835

Query: 579 R-------PPPGPATLAP--SRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVR 629
           +       P P  + L+P   +P L P+ E+  PP   G +     +L   P PG  S+ 
Sbjct: 836 QSEEPCLSPRPEESHLSPELEKPPLSPRPEK--PPEEPG-QCPAPEELPLFPPPGEPSLS 892

Query: 630 VSPPQPILSR-GRP 642
               +P LS  G P
Sbjct: 893 PLLGEPALSEPGEP 906



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 122/447 (27%), Positives = 157/447 (35%), Gaps = 86/447 (19%)

Query: 195  PSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISD 254
            P  ED  ++P   E    PP +  +     VV  L   PEE P           LS   +
Sbjct: 628  PPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP-----------LSPPPE 676

Query: 255  TLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMP 314
               T      S L  PPED+         P+ +P  P  +D +       +  LP P  P
Sbjct: 677  ESPTSPPPEASRLSPPPEDSPTSPP----PEDSPASPPPEDSLMSLPLEESPLLPLPEEP 732

Query: 315  SNFP--EPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFL 372
               P  E P  SP  +    S    PE P       HLS  +     +  P      A  
Sbjct: 733  QLCPRSEGPHLSPRPEEPHLSPR--PEEP-------HLSPQAEEPHLSPQPEEPCLCAVP 783

Query: 373  SSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQ---EEP 429
                L P+   P L P P     LH  P  + P L P P  P     P  + L    EEP
Sbjct: 784  EEPHLSPQAEGPHLSPQPEE---LHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEP 840

Query: 430  LFSPR---------------FPFPTVPPA-PGVSPLPAPAA-FPPTPQSVPSP------- 465
              SPR                P P  PP  PG  P P     FPP  +   SP       
Sbjct: 841  CLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPAL 900

Query: 466  --------APTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASP 517
                    +P P  + L P G  EP+  P    P   PP  SP    A+PP L+P     
Sbjct: 901  SEPGEPPLSPLPEELPLSPSG--EPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGE-- 956

Query: 518  PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTP 577
                        +    AK +   E PL ++ +L +P SP    PE  CT   P P P  
Sbjct: 957  -----------LEYPFGAKGDSDPESPL-AAPILETPISPP---PEANCT--DPEPVPPM 999

Query: 578  PRPPPGPATLAPSRPLLV-PKAERLSP 603
              PP   + + P+ P+L+ P   + SP
Sbjct: 1000 ILPPSPGSPVGPASPILMEPLPPQCSP 1026



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 94/359 (26%), Positives = 127/359 (35%), Gaps = 50/359 (13%)

Query: 264  PSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSF 323
            P P + P E       + +     P +PSL   +           P  P+P   P  PS 
Sbjct: 862  PRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSG 921

Query: 324  SPVVD-SLFSSGTLGPEVPP--ASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFL-LP 379
             P +   L     L P + P   ++A   LS    L+      G  D  + L++  L  P
Sbjct: 922  EPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETP 981

Query: 380  EDPKPRL---PPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQE--EPLFSPR 434
              P P      P PVPP +L              PP P  P+ P + +L E   P  SP 
Sbjct: 982  ISPPPEANCTDPEPVPPMIL--------------PPSPGSPVGPASPILMEPLPPQCSPL 1027

Query: 435  FPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPI-------ELLPLGYSEPAFGPC 487
                 VP     SP P+  + P  P SVPSP      +       EL  +   + +   C
Sbjct: 1028 LQHSLVPQN---SP-PSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPEC 1083

Query: 488  FSM-PRGKPPAPSPRGQKASP-PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPL 545
             ++ P    P PSP G  + P P+ APA            P        ++PE    P  
Sbjct: 1084 PALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGS 1143

Query: 546  VSSTLLRSPG--SPQETVPEFPCTFLP----------PTPAPTPPRPP--PGPATLAPS 590
            ++S L  SP    P+E  P  P    P          P      PR P  P P TL  S
Sbjct: 1144 LASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIKS 1202



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 106/369 (28%), Positives = 131/369 (35%), Gaps = 99/369 (26%)

Query: 334  GTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPP 393
            G LG   PP ++A T   G        + P  L +SA     FL P  P   +P P  P 
Sbjct: 2111 GALGS--PPPAAAPTIFIGSP------TTPAGLSTSA---DGFLKP--PAGSVPGPDSPG 2157

Query: 394  PL-LHYPP--PAKVPGLEPCPPPPFPPMAP--PTALLQEEPLFSPRFPFPT----VPPAP 444
             L L  PP  PA+VP  +P    P  P+ P  PTA     P   P +P PT     PP  
Sbjct: 2158 ELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTA-----PPTYPPYPSPTGAPAQPPML 2212

Query: 445  GVSPLPA---PAAFPPTPQSVPSPAP-TPFPIELLPLGYSEPAFGPCFSMPR-GKPPAPS 499
            G S  P    P  F  TP   P   P TP P       + +P    C S+     P +P 
Sbjct: 2213 GASSRPGAGQPGEFHTTPPGTPRHQPSTPDP-------FLKPR---CPSLDNLAVPESPG 2262

Query: 500  PRGQKASPPTLAPA---------------------TASPPTTAGSNNPCL-TQL--LTAA 535
              G KAS P L+P                      +  PP     ++P   T L  L   
Sbjct: 2263 VGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELK 2322

Query: 536  KPEQALEP--PLVSSTLLRSPG---SPQE---------TVPEFPCTFLP---------PT 572
             P+    P  P  S    +SPG    PQE         + P  P  F P         P 
Sbjct: 2323 TPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPP 2382

Query: 573  PAPTPPRPPPGPATLAPSRPLLVPKAERL--SPPAPSGSERRLSGDLSSMPGPGTLSVRV 630
              P P  PPP      P R L      R+  SP + S S+  L+        P  LS   
Sbjct: 2383 LTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLT--------PRPLSAEA 2434

Query: 631  SPPQPILSR 639
              P P+  R
Sbjct: 2435 FCPSPVTPR 2443



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 79/303 (26%), Positives = 101/303 (33%), Gaps = 69/303 (22%)

Query: 377  LLPEDPKPR---LPPPPVPPPLLH---YPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPL 430
            L P++P P     P PP  P +     Y  P   P L P P PP     PP +     P 
Sbjct: 2347 LRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPP-----PPESCCALPPR 2401

Query: 431  FSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPF-PIELLPLGYSEPA------ 483
              P  PF  VP +P  S   + +   P P S  +  P+P  P    P  YS P       
Sbjct: 2402 SLPSDPFSRVPASPQ-SQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSR 2460

Query: 484  --FGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQAL 541
              F P    PR +PP  + +    +  +L          AG       ++ +   P    
Sbjct: 2461 DPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVR 2520

Query: 542  EPPLVSSTLLRSP---------GSPQETVPEFPCTFLPPT--------PAPTPPRP---- 580
             P   +     SP         G P    P  P   LPP         P PT  +P    
Sbjct: 2521 SPGTGAFVGTPSPMRFTFPQAVGEPS-LKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTN 2579

Query: 581  -------------PPGPAT--------LAPSRPLLVPKAERLSPPAPSGSERRLSGDLSS 619
                         P GP++        L+P RP  V     L PPAP GS   LS   S 
Sbjct: 2580 YTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSV-----LPPPAPDGSLPYLSHGASQ 2634

Query: 620  MPG 622
              G
Sbjct: 2635 RSG 2637



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 80/340 (23%), Positives = 109/340 (32%), Gaps = 82/340 (24%)

Query: 332  SSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDP---KPRL-- 386
            S G LG      +S++ HL     +          D    ++ + L P+ P   +P    
Sbjct: 4115 SHGQLGSGSSSEASSVPHLLAQPSVSLG-------DQPGSMTQNLLGPQQPMLERPMQNN 4167

Query: 387  --PPPPVPPPLLHYPPPAKVPGLEP-------------CPPPPFPPMAPPT-----ALLQ 426
              P PP P P+L         G+ P                P    ++P       ALL 
Sbjct: 4168 TGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLM 4227

Query: 427  EEPLFSPRFPFPTVP-PAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFG 485
            +  L   +    T P   PG    P        PQ    P P   P++ L  G       
Sbjct: 4228 QRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAG------- 4280

Query: 486  PCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPL 545
                 P+G P  P+P G  ++ P L P   +PP                           
Sbjct: 4281 ---PRPQGPPRLPAPPGALSTGPVLGPVHPTPP--------------------------- 4310

Query: 546  VSSTLLRSPGSPQETVPEFPCTF-LPPTPAPTPPR-PPPGPATLAPSRPLLVPKAERLSP 603
                    P SPQE  P+ P     P +  PT  + PP  P T  P  P L P   R+SP
Sbjct: 4311 --------PSSPQE--PKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSP 4360

Query: 604  PAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPD 643
             A   ++   S  L     P  L+    P Q  L  G  D
Sbjct: 4361 AAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVPGHLD 4400



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 56/209 (26%), Positives = 66/209 (31%), Gaps = 57/209 (27%)

Query: 440  VPPAPGVSPLPAPAAFP------PT---------------------------------PQ 460
            +PP PG    P PAA P      PT                                 P 
Sbjct: 2106 IPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPP 2165

Query: 461  SVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTT 520
             VP+  P+  P  L P    EP F    + P   PP PSP G  A PP L  ++      
Sbjct: 2166 QVPAQVPSQDPFGLAPAYPLEPRFP---TAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQ 2222

Query: 521  AGS--NNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
             G     P  T     + P+  L+P        R P      VPE P         P   
Sbjct: 2223 PGEFHTTPPGTPRHQPSTPDPFLKP--------RCPSLDNLAVPESPGVGGGKASEPLLS 2274

Query: 579  RPPPGPATLAPSRPLLVPKAERLSPPAPS 607
             PP G      SR  L  K E L   +PS
Sbjct: 2275 PPPFG-----ESRKALEVKKEELGASSPS 2298



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 58/233 (24%), Positives = 71/233 (30%), Gaps = 46/233 (19%)

Query: 390  PVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPL 449
            P+ P      P +   GL P  PPP   +AP        P   P    P     P   P 
Sbjct: 2330 PLTPRASQVEPQSPGLGLRPQEPPPAQALAP-------SPPSHPDIFRPGSYTDPYAQPP 2382

Query: 450  PAPAAFPPTPQSVPSPAPTPFPIE------------------LLPLGYSEPAFGPCFSMP 491
              P   PP P+S  +  P   P +                  L P   S  AF P    P
Sbjct: 2383 LTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTP 2442

Query: 492  RGKPPAP------SPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTA--------AKP 537
            R + P P       P+ +    P   P    PP  A          L A        A P
Sbjct: 2443 RFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGP 2502

Query: 538  EQALEPPLVSS---TLLRSPGSPQETVPEFPCTFLPP----TPAPTPPRPPPG 583
               L   + S      +RSPG+        P  F  P     P+  PP P PG
Sbjct: 2503 AGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPG 2555



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 24/66 (36%), Positives = 26/66 (39%), Gaps = 6/66 (9%)

Query: 392  PPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPA 451
            PPP    PPP+      P  P P  P   P   L  EPL  P  P P    +   S  P 
Sbjct: 4909 PPPEEPSPPPS------PLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPK 4962

Query: 452  PAAFPP 457
            P A PP
Sbjct: 4963 PRARPP 4968



 Score = 37.0 bits (84), Expect = 0.076
 Identities = 80/332 (24%), Positives = 105/332 (31%), Gaps = 65/332 (19%)

Query: 227  PVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDL 286
            P  LG  +    G  L  L     D+     T     P   Q+ P+   +G      P  
Sbjct: 2301 PPNLGFVDSPSSGTHLGGLELKTPDVFKAPLT-----PRASQVEPQSPGLGLRPQEPPPA 2355

Query: 287  TPLQPSLDDFMDI------SDFFTNSRL---PQPPMPSNFPEPPSFSPVVDSLFSSGTLG 337
              L PS     DI      +D +    L   PQPP P +    P  S   D  FS     
Sbjct: 2356 QALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDP-FSRVPAS 2414

Query: 338  PEVPPASSAMTHLSGHSRLQARNSCPGPLDS------------SAFLSSDFLLPEDPKPR 385
            P+    SS+ + L+    L A   CP P+              S   S D   P    PR
Sbjct: 2415 PQ--SQSSSQSPLTPRP-LSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPR 2471

Query: 386  LPPPPVP----------------PPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQE-- 427
              PP V                 P  L   P  ++    P   PP    +P T       
Sbjct: 2472 PQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTP 2531

Query: 428  ------------EPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPT-PFPIEL 474
                        EP   P  P P +PP  G++    P      PQS      T  F    
Sbjct: 2532 SPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSG 2591

Query: 475  LPLGYSEPAFGPCFSMPRGKPPA----PSPRG 502
             PLG S  + G  + +   +PP+    P+P G
Sbjct: 2592 SPLGPSSGSTGESYGLSPLRPPSVLPPPAPDG 2623



 Score = 37.0 bits (84), Expect = 0.076
 Identities = 36/124 (29%), Positives = 44/124 (35%), Gaps = 31/124 (25%)

Query: 390  PVPPPLLHYPPPAKVPGLEP---CPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGV 446
            P P P   +     V  L+      PPP  P  PP          SP  P P  PP   +
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPP----------SPLAPSPASPPTEPL 4933

Query: 447  SPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKAS 506
              LP      P       P P+P     LPL  S  +  P    PR +PP     G+ + 
Sbjct: 4934 VELPTEPLAEP-------PVPSP-----LPLASSPESARP---KPRARPP---EEGEDSR 4975

Query: 507  PPTL 510
            PP L
Sbjct: 4976 PPRL 4979



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 106/470 (22%), Positives = 154/470 (32%), Gaps = 117/470 (24%)

Query: 300  SDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQAR 359
            S   T + L  PP P +   PP+  P V     +G     V P+     H    +   AR
Sbjct: 4608 SQLLTKNNLSNPPTPPS-SLPPTPPPSVQQKMVNG-----VTPSEELGEHPKDAA--SAR 4659

Query: 360  NSCPGPLDSSAFLSSDFL--LPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP-----P 412
            +S     D+S   S D L  LP  P  +     +        P + VP   P        
Sbjct: 4660 DSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEA 4719

Query: 413  PPFPPMAPPTALLQEEPLFSPRFPF---PTVPPAPGVSP-----LPAPAAFPPTP----- 459
            P FP +       QE+   SP  P     ++P  P   P     L  P   P T      
Sbjct: 4720 PRFPHLGSGR-WEQEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGK 4778

Query: 460  ------------------------------QSVPSPAPTPFPIELLPLGYSEPAFGPCFS 489
                                            +P+     FP      G +EP  G    
Sbjct: 4779 GSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAG-TEPKKGEAEG 4837

Query: 490  MPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPL---- 545
             P GK      +     P  L    A  P     +   +  LL    P  A EPP     
Sbjct: 4838 -PGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESP--APEPPTQHSY 4894

Query: 546  ---VSSTLLRSPGSPQETVPEFPCTFLPPTP-APTPPRPPPGPATLAPSRPLLVPKAERL 601
               VS+  +R   +P    PE P    PP+P AP+P  PP  P    P+ PL        
Sbjct: 4895 TYNVSNLDVRQLSAPP---PEEPSP--PPSPLAPSPASPPTEPLVELPTEPL-------A 4942

Query: 602  SPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENR--RITHISAEQ 659
             PP PS             P P   S   + P+P   R RP     ++R  R+      +
Sbjct: 4943 EPPVPS-------------PLPLASSPESARPKP---RARPPEEGEDSRPPRLKKWKGVR 4986

Query: 660  KRRFNIKLGFDTLHGLVSTLSAQPSLKERAGLQEEAQQLRDEIEELNAAI 709
             +R  + L                ++++ +G QE+ +++ + +E+L  A+
Sbjct: 4987 WKRLRLLL----------------TIQKGSGRQEDEREVAEFMEQLGTAL 5020



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 50/186 (26%), Positives = 70/186 (37%), Gaps = 40/186 (21%)

Query: 499  SPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQ 558
            SP+ Q+     L P   + P    S+   L   L     EQ    P VSS     P + Q
Sbjct: 3986 SPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQ 4045

Query: 559  ------ETVPEFPCTFLPPTPAPT----------PPRPPPGPATLAPSRPLLVPKAER-- 600
                   T PE   T  P    P+           P+P P P++L    PL +P  ++  
Sbjct: 4046 GGPLAIGTTPESMAT-EPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQ 4104

Query: 601  --LSPPAPSGSERRL----SGDLSSMP------------GPGTLSVR-VSPPQPILSRGR 641
              L   A  GS  +L    S + SS+P             PG+++   + P QP+L   R
Sbjct: 4105 VSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLE--R 4162

Query: 642  PDSNKT 647
            P  N T
Sbjct: 4163 PMQNNT 4168



 Score = 30.4 bits (67), Expect = 7.1
 Identities = 55/213 (25%), Positives = 76/213 (35%), Gaps = 36/213 (16%)

Query: 332  SSGTLGPE----VPPASSAMTHLSG----HSRLQARNSCPG--PLDSSAFLSSDFLLPED 381
            ++G +GP       P+S A   LS      +  Q ++S  G  P   S  +      P D
Sbjct: 2710 AAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSD 2769

Query: 382  PKPRLPPPPVPPPLLHYPPPAKVPGLEP-CPPPPFPPMAP-------------PTALLQE 427
             +   PPPP  P  +       V G +      P+P   P              TA    
Sbjct: 2770 DRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAATSM 2829

Query: 428  EPLFSPRFPFPTVPPAPGVSPLPAPAA-----FPPTPQSVPSPAPTPFPIELLPLGYS-E 481
                S RFP  T  P  G   L +P A      P   + VP PA    P + + L ++ +
Sbjct: 2830 RFAMSARFP-STPGPELGRQALGSPLAGISTRLPGPGEPVPGPAG---PAQFIELRHNVQ 2885

Query: 482  PAFGPCFSMPRGKPPAPSPRGQKAS--PPTLAP 512
               GP  +   G+ P   PR    S  P  LAP
Sbjct: 2886 KGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAP 2918


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 101/399 (25%), Positives = 145/399 (36%), Gaps = 57/399 (14%)

Query: 260  TQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPE 319
            T S P+    PP  +       + P  TP  P+             +  P PP+ +    
Sbjct: 1398 TPSPPTTTPSPPPTS----TTTLPPTTTPSPPTTTTTTP-----PPTTTPSPPITTTTTP 1448

Query: 320  PPSFSPVVDSLFSSGTLGPEV----PPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSD 375
            PP+ +P      S+ T  P      PP ++     +  S      + P P  + +  ++ 
Sbjct: 1449 PPTTTP--SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1506

Query: 376  FLLPEDPKPRLPP-----PPV-----PPPLLHYPPPAKVPGLEPCP----PPPFPPMAPP 421
             + P      LPP     PP      PPP     PP   P   P      PP   P  PP
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP 1566

Query: 422  TALLQEEPLFSPRFPFPTVPPAPGV---SPLPAPAAFPP-TPQSVPSPAPTPFPIELLPL 477
            T      P  +P  P  T P  P +   +P P     PP T  + P P  TP P    P+
Sbjct: 1567 TTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI 1626

Query: 478  GYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKP 537
              + P      ++P    P+P P      PPT  P   SPPTT   + P    + T   P
Sbjct: 1627 --TPPT--STTTLPPTTTPSPPPTTTTTPPPTTTP---SPPTTTTPSPP----ITTTTTP 1675

Query: 538  EQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLL-VP 596
                 PP        +P SP  T P  P T +  TP+PT     P   T  PS      P
Sbjct: 1676 -----PPTT------TPSSPITTTPSPPTTTM-TTPSPTTTPSSPITTTTTPSSTTTPSP 1723

Query: 597  KAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
                ++ P+P+ +    +  ++++P   T S   + P P
Sbjct: 1724 PPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLP 1762



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 84/308 (27%), Positives = 104/308 (33%), Gaps = 48/308 (15%)

Query: 382  PKPRLPPPPVPPPLLHYPPPAKVPGLEPCP---PPPFPPMAPPTALLQEEPLFSPRFPFP 438
            P  +    P PP     PPP     L P     PP      PP       P+ +   P P
Sbjct: 1391 PMDKCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPP 1450

Query: 439  TVPPAPGVS----PLPAPAAFPPT-----PQSVPS----------PAPTPFPIELLPLGY 479
            T  P+P +S    P P     PPT     P + PS          P  TP P    P+  
Sbjct: 1451 TTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI-- 1508

Query: 480  SEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQ 539
            + PA     ++P    P+P        PPT  P   SPPTT     P  T   T   P  
Sbjct: 1509 TPPA--STTTLPPTTTPSPPTTTTTTPPPTTTP---SPPTTTPITPPTST---TTLPPTT 1560

Query: 540  ALEPPLVSSTL---LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVP 596
               PP  ++T      +P  P  T P  P T    TP PT    PP   T  P  P   P
Sbjct: 1561 TPSPPPTTTTTPPPTTTPSPPTTTTPS-PPTITTTTPPPTTTPSPPTTTTTTPP-PTTTP 1618

Query: 597  KAERLSPPAPSGSERRLSGDLSSMPGPGTLS-----------VRVSPPQPILSRGRPDSN 645
                 +P  P  S   L    +  P P T +              +P  PI +   P   
Sbjct: 1619 SPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPT 1678

Query: 646  KTENRRIT 653
             T +  IT
Sbjct: 1679 TTPSSPIT 1686



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 89/358 (24%), Positives = 122/358 (34%), Gaps = 45/358 (12%)

Query: 253  SDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPP 312
            S  + T T   P+    PP    +       P  TP  P+       +     +     P
Sbjct: 1439 SPPITTTTTPPPTTTPSPP----ISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTP 1494

Query: 313  MPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFL 372
             P+  P PP+ +P+     S+ TL P   P+    T            + P P  + +  
Sbjct: 1495 PPTTTPSPPTTTPITPPA-STTTLPPTTTPSPPTTT-----------TTTPPPTTTPSPP 1542

Query: 373  SSDFLLPEDPKPRLPPP--PVPPPLLHYPPPAKVPGLEPCPPPPFPPM----APPTALLQ 426
            ++  + P      LPP   P PPP     PP       P    P PP      PP     
Sbjct: 1543 TTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTP 1602

Query: 427  EEPLFSPRFPFPTVPPAPG----VSPLPAPAAFPPTPQSVPSPAPTPF---PIELLPLGY 479
              P  +   P PT  P+P     ++P  +    PPT  + PSP PT     P    P   
Sbjct: 1603 SPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPT--TTPSPPPTTTTTPPPTTTPSPP 1660

Query: 480  SEPAFGPCFSMPRGKPPAPSPRGQ---KASPPTLAPATASPPTTAGSNNPCLTQLLTAAK 536
            +     P  +     PP  +P        SPPT    T SP TT  S       + T   
Sbjct: 1661 TTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSS------PITTTTT 1714

Query: 537  PEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPT----PAPTPPRPP-PGPATLAP 589
            P     P    +T+     +   + P    T LPPT    P  T P PP   P T +P
Sbjct: 1715 PSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSP 1772



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 90/348 (25%), Positives = 117/348 (33%), Gaps = 61/348 (17%)

Query: 258  TMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFT--NSRLPQPPMPS 315
            T T S P+    PP            P  TP  P+       +   T   +  P PP  +
Sbjct: 1474 TTTPSPPTTTPSPPTTT----TTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTT 1529

Query: 316  NFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSD 375
                PP+ +P      S  T  P  PP S+               + P P  ++      
Sbjct: 1530 TTTPPPTTTP------SPPTTTPITPPTSTTTL---------PPTTTPSPPPTTTTTPPP 1574

Query: 376  FLLPEDPKPRLPPPPV-----PPPLLHYPPPAKVPGLEPCPPPPFPP----MAPPTALLQ 426
               P  P    P PP      PPP     PP       P    P PP    + PPT+   
Sbjct: 1575 TTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTT 1634

Query: 427  EEPLFSPR-------FPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPF-PIELLPLG 478
              P  +P         P PT  P+P  +  P+P   P T  + P P  TP  PI   P  
Sbjct: 1635 LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSP---PITTTTTPPPTTTPSSPITTTP-- 1689

Query: 479  YSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPE 538
                      S P      PSP    +SP T    T +P +T   + P  T  +T   P 
Sbjct: 1690 ----------SPPTTTMTTPSPTTTPSSPIT---TTTTPSSTTTPSPPPTT--MTTPSPT 1734

Query: 539  QALEPPLVSSTLL--RSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGP 584
                PP  + T L   +  SP  T P  P +  PPT +P     P  P
Sbjct: 1735 TTPSPPTTTMTTLPPTTTSSPLTTTP-LPPSITPPTFSPFSTTTPTTP 1781



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 67/279 (24%), Positives = 90/279 (32%), Gaps = 45/279 (16%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3981 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4039

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 4040 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 4098

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 4099 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 4158

Query: 567  TFLPPTPAP-----------------TPPRPPPGPATLAPSRPLLVPKAE-RLSPPAPSG 608
            T + PTP P                 TP   P G  T  P+     P AE   S P P  
Sbjct: 4159 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPES 4218

Query: 609  SERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKT 647
            S  + S   SS     T  +   PP   ++   P S  T
Sbjct: 4219 STPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPT 4257



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 60/227 (26%), Positives = 77/227 (33%), Gaps = 24/227 (10%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 4096 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4154

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGS 523
            I           P G   P   P  +      P P+P G +  PPT   +TA       S
Sbjct: 4155 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTGPPTHT-STAPIAELTTS 4212

Query: 524  NNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTP-APTPPR--- 579
            N P  +   +  +  ++   PL  ST L S   P     E   T  P TP APT      
Sbjct: 4213 NPPPES---STPQTSRSTSSPLTESTTLLSTLPP---AIEMTSTAPPSTPTAPTTTSGGH 4266

Query: 580  ---PPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGP 623
               PPP   T  P  P         S P PS  +   +   +  P P
Sbjct: 4267 TLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTP 4313



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 55/209 (26%), Positives = 78/209 (37%), Gaps = 31/209 (14%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 4119 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 4171

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
             P   P  +      P P+P G +  PPT    T++ P         + +L T+  P ++
Sbjct: 4172 TPTTTP-ITTTTTVTPTPTPTGTQTGPPT---HTSTAP---------IAELTTSNPPPES 4218

Query: 541  LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPT---PAPTPPRPPPGPATLAPSRPLLVPK 597
              P    ST   SP +   T+     + LPP     +  PP  P  P T +    L  P 
Sbjct: 4219 STPQTSRST--SSPLTESTTL----LSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPP 4272

Query: 598  AERLSPPAPSGSERRLSGDLSSMPGPGTL 626
            +   SPP      R  +   SS P P T+
Sbjct: 4273 STTTSPPGT--PTRGTTTGSSSAPTPSTV 4299



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 1957 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2015

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2016 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2074

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2075 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2134

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 2135 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2193



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 2141 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2199

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2200 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2258

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2259 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2318

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 2319 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2377



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 2325 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2383

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2384 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2442

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2443 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2502

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 2503 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2561



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 2509 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2567

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2568 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2626

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2627 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2686

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 2687 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2745



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 2693 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2751

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2752 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2810

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2811 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2870

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 2871 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2929



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 2877 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2935

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 2936 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2994

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 2995 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3054

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3055 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3113



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3061 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3119

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 3120 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3178

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 3179 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3238

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3239 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3297



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3245 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3303

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 3304 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3362

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 3363 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3422

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3423 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3481



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3429 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3487

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 3488 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3546

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 3547 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3606

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3607 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3665



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3613 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3671

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 3672 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3730

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 3731 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3790

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3791 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3849



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 55/239 (23%), Positives = 79/239 (33%), Gaps = 42/239 (17%)

Query: 412  PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
            P P     P T  +      +P  P PT    P  +P+       PTP    +  PT  P
Sbjct: 3797 PTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3855

Query: 472  IELL--------PLGYSEPAFGPCFSMPRGKPPAPSPRGQKA--SPPTLAPATASP-PTT 520
            I           P G   P   P  +      P P+P G +   + P     T +P PT 
Sbjct: 3856 ITTTTTVTPTPTPTGTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 3914

Query: 521  AGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPC 566
             G+  P  T + T         P         P+ ++T +    +P       T P    
Sbjct: 3915 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3974

Query: 567  TFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
            T + PTP PT  + P            P P       P   P      ++P P P+G++
Sbjct: 3975 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4033



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 58/242 (23%), Positives = 82/242 (33%), Gaps = 50/242 (20%)

Query: 409  PCPPPPFP-----PMAP-PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSV 462
            P PP   P      + P PT    + P  +P     TV P P  +    P   P T  + 
Sbjct: 1893 PTPPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 1952

Query: 463  PSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----P 517
             +P PT       P G   P   P  +      P P+P G +   PT  P T +      
Sbjct: 1953 VTPTPT-------PTGTQTPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPT 2002

Query: 518  PTTAGSNNPCLTQLLTAAKPEQALEP---------PLVSSTLLRSPGSP-----QETVPE 563
            PT  G+  P  T + T         P         P+ ++T +    +P       T P 
Sbjct: 2003 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2062

Query: 564  FPCTFLPPTPAPTPPRPP------------PGPATLAPSRPLLVP--KAERLSP-PAPSG 608
               T + PTP PT  + P            P P       P   P      ++P P P+G
Sbjct: 2063 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2122

Query: 609  SE 610
            ++
Sbjct: 2123 TQ 2124



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 2095 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 2147

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 2148 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2204

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 2205 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2264

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 2265 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2308



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 2279 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 2331

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 2332 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2388

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 2389 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2448

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 2449 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2492



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 2463 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 2515

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 2516 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2572

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 2573 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2632

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 2633 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2676



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 2647 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 2699

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 2700 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2756

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 2757 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 2816

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 2817 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 2860



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 2831 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 2883

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 2884 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2940

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 2941 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3000

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3001 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3044



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3015 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3067

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3068 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3124

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 3125 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3184

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3185 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3228



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3199 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3251

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3252 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3308

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 3309 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3368

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3369 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3412



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3383 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3435

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3436 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3492

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 3493 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3552

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3553 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3596



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3567 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3619

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3620 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3676

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 3677 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3736

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3737 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3780



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3751 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3803

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3804 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3860

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 3861 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 3920

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 3921 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 3964



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 53/224 (23%), Positives = 76/224 (33%), Gaps = 44/224 (19%)

Query: 421  PTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            PT    + P  +P     TV P P  +    P   P T  +  +P PT       P G  
Sbjct: 3935 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT-------PTGTQ 3987

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATAS-----PPTTAGSNNPCLTQLLTAA 535
             P   P  +      P P+P G +   PT  P T +      PT  G+  P  T + T  
Sbjct: 3988 TPTTTP-ITTTTTVTPTPTPTGTQT--PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 4044

Query: 536  KPEQALEP---------PLVSSTLLRSPGSP-----QETVPEFPCTFLPPTPAPTPPRPP 581
                   P         P+ ++T +    +P       T P    T + PTP PT  + P
Sbjct: 4045 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTP 4104

Query: 582  ------------PGPATLAPSRPLLVP--KAERLSP-PAPSGSE 610
                        P P       P   P      ++P P P+G++
Sbjct: 4105 TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQ 4148



 Score = 36.6 bits (83), Expect = 0.099
 Identities = 57/242 (23%), Positives = 80/242 (33%), Gaps = 45/242 (18%)

Query: 388  PPPVPPPLLHYPPP----AKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA 443
            P P P      PP     A +  L    PPP     P T+     PL        T+PPA
Sbjct: 4186 PTPTPTGTQTGPPTHTSTAPIAELTTSNPPP-ESSTPQTSRSTSSPLTESTTLLSTLPPA 4244

Query: 444  PGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQ 503
                 +   +  PP+  + P+       +   P   + P   P      G   AP+P   
Sbjct: 4245 -----IEMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTP--- 4296

Query: 504  KASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPE 563
              S       +A  PT    + P + +  T  +P  +    L+   L  +  +P E V  
Sbjct: 4297 --STVQTTTTSAWTPTPTPLSTPSIIRT-TGLRPYPS--SVLICCVLNDTYYAPGEEVYN 4351

Query: 564  -------------FPCTF------LPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPP 604
                           CT        P TP+PTP    P  +T  PS+P   P     S P
Sbjct: 4352 GTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPT---PSKSTPTPSKPSSTP-----SKP 4403

Query: 605  AP 606
             P
Sbjct: 4404 TP 4405



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 50/215 (23%), Positives = 62/215 (28%), Gaps = 38/215 (17%)

Query: 258  TMTQSGPSPLQL---PPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMP 314
            T T   P+P       P    +     + P  TP          I+   T +  P P   
Sbjct: 4134 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4193

Query: 315  SNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSS 374
               P   + +  +  L +S       PP SS           Q   S   PL  S  L S
Sbjct: 4194 QTGPPTHTSTAPIAELTTSNP-----PPESSTP---------QTSRSTSSPLTESTTLLS 4239

Query: 375  DFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPR 434
              L P        PP  P        P    G     PPP    +PP             
Sbjct: 4240 T-LPPAIEMTSTAPPSTPTA------PTTTSGGHTLSPPPSTTTSPPGT----------- 4281

Query: 435  FPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTP 469
               PT     G S  P P+    T  S  +P PTP
Sbjct: 4282 ---PTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTP 4313


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 105/347 (30%), Positives = 133/347 (38%), Gaps = 50/347 (14%)

Query: 311  PPMPSNFPEPP-SFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSS 369
            P +  +FP+P  SF+PV+             PP S+ M   +G  +       P PL   
Sbjct: 693  PSLQQHFPDPAMSFAPVL-------------PPPSTPMP--TGPGQPAPPGQQPPPLAQP 737

Query: 370  AFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEP 429
              L         P+P +P  PVPP L  Y  PA   G      P   P AP   L Q  P
Sbjct: 738  TPLPQVLA----PQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPP 793

Query: 430  LFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPF-PIELLP-LGYSEPAFGPC 487
               P    P + P  G+  LP      PT    P P P  F P  +LP L    P   P 
Sbjct: 794  QMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPA 853

Query: 488  FSM-------PRGKPPAPSPRGQKASPPTLAP--ATASPPTTAGSNNPCLTQLLTAAKPE 538
              +       P G P A   R    + P   P  A A P   A S +  + QL     P 
Sbjct: 854  LPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQL-----PG 908

Query: 539  QALEP---PLVSSTLLRSPGSPQETVPEFPCTFLPPTPA----PT-PPRPPPGPATLAPS 590
            Q + P   P ++ T +  P SP  TV     T  PP PA    PT PP+P   P    P 
Sbjct: 909  QPVYPAAFPQMAPTDV--PPSPHHTVQNMRAT--PPQPALPPQPTLPPQPVLPPQPTLPP 964

Query: 591  RPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPIL 637
            +P+L P+  R  PP P    + +      +P    L VR  P QP L
Sbjct: 965  QPVLPPQPTR--PPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHL 1009



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 127/465 (27%), Positives = 161/465 (34%), Gaps = 113/465 (24%)

Query: 266 PLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPE------ 319
           P   P E   VG+ D  +    PLQ  +        +   +  P PP P   PE      
Sbjct: 548 PALQPKEQQDVGSPDKARGPPVPLQVQVT-------YHAQAGQPGPPEPEE-PEADQHLL 599

Query: 320 PPSF-----SPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNS-----CPGPLDSS 369
           PP+      S   DS F SG        + S+   +   S   A  S     C  P+   
Sbjct: 600 PPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEG 659

Query: 370 AFLSSDF----------LLPEDPKPRLPPPPVPPPLL-HYPPPAKVPGLEPCPPPPFPPM 418
             L                P  P   +P P  PP L  H+P PA      P  PPP  PM
Sbjct: 660 PVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAM--SFAPVLPPPSTPM 717

Query: 419 -------APPTALLQEEPLFSPRFPFPTV-PPAPGVSPLPAPAAFPP--TPQS-VPSPA- 466
                  APP    Q+ P  +   P P V  P P V   P P   PP   P S V +PA 
Sbjct: 718 PTGPGQPAPPG---QQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQ 774

Query: 467 --PTPFP-IELLPLGYSEPAFGPCFSMP--------RGKPPA----------PSPRGQKA 505
             P   P   L PL    P   P   +P         G PPA          P P  Q  
Sbjct: 775 LKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYF 834

Query: 506 SPPTLAPATASP-----------------PTTAGSNNPCLTQL--LTAAKPEQALEPPLV 546
           SP  + P+ A+P                 P  A    PC T +    A  P  A+ PP V
Sbjct: 835 SPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGV 894

Query: 547 SSTLLRS-----PGSP--QETVPEFPCTFLPPTP-------APTPPRPPPGPATLAPSRP 592
           ++  + S     PG P      P+   T +PP+P         TPP+P   P    P +P
Sbjct: 895 AALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQP 954

Query: 593 LLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPIL 637
           +L P  +   PP P      L    +  P P      + PPQP+L
Sbjct: 955 VLPP--QPTLPPQPV-----LPPQPTRPPQPVLPPQPMLPPQPVL 992



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 98/384 (25%), Positives = 138/384 (35%), Gaps = 75/384 (19%)

Query: 311  PPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSA 370
            PP+    P P   +P    +     + P +PP  +  + +   ++L+       PL   A
Sbjct: 732  PPLAQPTPLPQVLAP--QPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLA 789

Query: 371  FLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPC----PPPPFPPMAPPT---- 422
             +           P++PP PV PP+    P A + GL P     P    PP+ PP     
Sbjct: 790  QVP----------PQMPPIPVVPPIT---PLAGIDGLPPALPDLPTATVPPVPPPQYFSP 836

Query: 423  -----ALLQEEPLFSPRFPFPTVP-PAPGVSPLPAPAA--FPPTPQSVPSPAPTPFPIEL 474
                 +L    P  SP  P   V  P P  +PL  P     P  P ++P  A  P  +  
Sbjct: 837  AVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAA 896

Query: 475  LPLGYS------EPAFGPCFSM--PRGKPPAP--SPRGQKASPP--------TLAPATAS 516
            L +  +      +P +   F    P   PP+P  + +  +A+PP        TL P    
Sbjct: 897  LSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVL 956

Query: 517  PPTTAGSNNPCLTQLLT-----AAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPP 571
            PP       P L    T        P+  L P  V       P  P+   P  P    P 
Sbjct: 957  PPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPA 1016

Query: 572  T----------PAP--------TPPRPPPGPATLAPSRP-LLVPKAERLSPPAPSGSERR 612
                       PAP         P  P P  A L+P  P +L+P A  L P  PS S   
Sbjct: 1017 ATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPS-SLAT 1075

Query: 613  LSGDLSSMP-GPGTLSVRVSPPQP 635
            +S  + S+P    TL    +PP P
Sbjct: 1076 VSASVQSVPTQTATLLPPANPPLP 1099



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 91/326 (27%), Positives = 118/326 (36%), Gaps = 53/326 (16%)

Query: 307  RLPQPP-----MPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNS 361
            +LP PP     MP     P +  P    L +    G       SA+  L G     A   
Sbjct: 860  KLPHPPGAPLAMPCRTIVPNA--PATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFP 917

Query: 362  CPGPLD--SSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMA 419
               P D   S   +   +    P+P LPP P  PP             +P  PP   P  
Sbjct: 918  QMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPP-------------QPVLPPQ--PTL 962

Query: 420  PPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPA--PTPFPIELLPL 477
            PP  +L          P PT PP P + P P     PP P   P PA    P P++    
Sbjct: 963  PPQPVLP---------PQPTRPPQPVLPPQP---MLPPQPVLPPQPALPVRPEPLQPHLP 1010

Query: 478  GYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKP 537
              + PA  P   +  G  PAP      A  PT+      P   A   +P L ++L  A P
Sbjct: 1011 EQAAPAATPGSQILLGH-PAPYAVDVAAQVPTV------PVPPAAVLSPPLPEVLLPAAP 1063

Query: 538  EQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP---PPGPATLAPSRPLL 594
            E  L P   SS  L +  +  ++VP    T LPP   P P  P    P P       P+ 
Sbjct: 1064 E--LLPQFPSS--LATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQ 1119

Query: 595  VPKAERLSPPA-PSGSERRLSGDLSS 619
              +A +  PP  P   E     D++S
Sbjct: 1120 EEQASQDKPPGLPQSCESYGGSDVTS 1145



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 69/235 (29%), Positives = 78/235 (33%), Gaps = 48/235 (20%)

Query: 380  EDPKPRLPPPPVPPPLLHYPPPAKVPG------LEPCPPPPF--------------PPMA 419
            E P P  P    P PL   PP A          L     P F              PP A
Sbjct: 1320 EHPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGA 1379

Query: 420  PPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAA-------FPPTPQSVPSPAPTPFPI 472
            PP  L    P   P    P    AP  S +P PA+        P TPQ + S   T  P+
Sbjct: 1380 PPAPLAPSSP---PVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPL 1436

Query: 473  ---ELLPLGYSEPAFG--PCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPC 527
                  PL       G  PC   P     A S R   A    L P    P   +G+  P 
Sbjct: 1437 AETHEAPLAVQPLVVGLAPCTPAPE----AASTRDASAPREPLPPPAPEPSPHSGTPQPA 1492

Query: 528  LTQ---LLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPR 579
            L Q   LL AA    +    L +S L   P  P  TVP  P + L       PPR
Sbjct: 1493 LGQPAPLLPAAVGAVS----LATSQLPSPPLGP--TVPPQPPSALESDGEGPPPR 1541



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 64/245 (26%), Positives = 84/245 (34%), Gaps = 37/245 (15%)

Query: 394  PLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFP-FPTVPPAPGVSPLPAP 452
            P+  +P P       P P    PP A   +   ++ L S   P F         +    P
Sbjct: 1317 PVAEHPAPEAPESSPPLPLSSLPPEASQDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNP 1376

Query: 453  AAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTL-A 511
               PP P +  SP     P+  LP   + PA     +MP       S  G   +P  L +
Sbjct: 1377 PGAPPAPLAPSSP-----PVTALPQDGAAPATS---TMPEPASGTASQAGGPGTPQGLTS 1428

Query: 512  PATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPP 571
                S P       P   Q L          P   S+   R   +P+E +P       PP
Sbjct: 1429 ELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAAST---RDASAPREPLP-------PP 1478

Query: 572  TPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMP-GPGTLSVRV 630
             P P+P    P PA   P+ PLL         PA  G+    +  L S P GP       
Sbjct: 1479 APEPSPHSGTPQPALGQPA-PLL---------PAAVGAVSLATSQLPSPPLGP------T 1522

Query: 631  SPPQP 635
             PPQP
Sbjct: 1523 VPPQP 1527



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 107/448 (23%), Positives = 149/448 (33%), Gaps = 71/448 (15%)

Query: 262  SGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPP 321
            S P PL   P +A   +A       +  QPS   F+      + +    PP     P  P
Sbjct: 1330 SPPLPLSSLPPEASQDSAPYKDQLSSKEQPS---FLASQQLLSQAGPSNPPGAPPAPLAP 1386

Query: 322  SFSPVV----DSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDF- 376
            S  PV     D    + +  PE  PAS   +   G    Q   S    L++S  L+    
Sbjct: 1387 SSPPVTALPQDGAAPATSTMPE--PASGTASQAGGPGTPQGLTS---ELETSQPLAETHE 1441

Query: 377  -----------LLPEDPKPRL--------PPPPVPPPLLHYPPPAKVPGLEPCPPPPFPP 417
                       L P  P P          P  P+PPP     P +  P      P P  P
Sbjct: 1442 APLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLP 1501

Query: 418  MAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPL 477
             A     L    L SP    PTVPP P  S L +    PP               +L  L
Sbjct: 1502 AAVGAVSLATSQLPSPPLG-PTVPPQP-PSALESDGEGPPPRVGFVDSTIKSLDEKLRTL 1559

Query: 478  GYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKP 537
             Y E    P  S   G P     R       TL P     P     +  C   L     P
Sbjct: 1560 LYQEHV--PTSSASAGTPVEVGDRDF-----TLEPLRGDQP----RSEVCGGDLALPPVP 1608

Query: 538  EQAL-------EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPG------- 583
            ++A+       +P +  S L  + G+  E       T      A + PR   G       
Sbjct: 1609 KEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMT------AESSPRSMLGYDRDGRQ 1662

Query: 584  ---PATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGP---GTLSVRVSPPQPIL 637
                + + PS P  VP   R +   P+  +   +G+ S+ P P   GT+  + S PQ + 
Sbjct: 1663 VASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLG 1722

Query: 638  SRGRPDSNKTENRRITHISAEQKRRFNI 665
            +R      K   ++     A+   RF++
Sbjct: 1723 ARALGSPRKRPEQQDVSSPAKTVGRFSV 1750



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 39/142 (27%), Positives = 56/142 (39%), Gaps = 30/142 (21%)

Query: 498  PSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSP 557
            P+P   ++SPP   P ++ PP  +  + P   QL +  +P        ++S  L S   P
Sbjct: 1322 PAPEAPESSPPL--PLSSLPPEASQDSAPYKDQLSSKEQPS------FLASQQLLSQAGP 1373

Query: 558  QETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDL 617
                               PP  PP P  LAPS P +    +  + PA S      SG  
Sbjct: 1374 SN-----------------PPGAPPAP--LAPSSPPVTALPQDGAAPATSTMPEPASGTA 1414

Query: 618  SSMPGPGT---LSVRVSPPQPI 636
            S   GPGT   L+  +   QP+
Sbjct: 1415 SQAGGPGTPQGLTSELETSQPL 1436



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 26/83 (31%), Positives = 29/83 (34%), Gaps = 11/83 (13%)

Query: 405 PGLE----PCPPPPFPP------MAPPTALLQEEPLFSPRFPFPTVPPA-PGVSPLPAPA 453
           PGLE    P P PP P       +     L+ E     P  P P    A PG    PA A
Sbjct: 55  PGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADA 114

Query: 454 AFPPTPQSVPSPAPTPFPIELLP 476
              P     P P P    +E  P
Sbjct: 115 GPEPVGTQEPGPDPIAAAVETAP 137


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 78/271 (28%), Positives = 101/271 (37%), Gaps = 29/271 (10%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEP----CPPPPFPPMAPPTALLQEEPLFSPRF 435
           E  + +LPPPP+ PP    PPP   P   P    CPPPP PP++PP       PL     
Sbjct: 395 EKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPP-PPVSPP-------PL----- 441

Query: 436 PFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRG-K 494
           P P  PPA        P   P T        P      L P   +E       + P G  
Sbjct: 442 PSPPPPPAQEEQEESPPPVVPATCSRKRGRPP------LTPSQRAERE--AARAGPEGTS 493

Query: 495 PPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPP--LVSSTLLR 552
           PP P+P      PP  +P  A   TT   N       + +A+  + ++ P   +     +
Sbjct: 494 PPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPK 553

Query: 553 SPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERR 612
            P      V   P T  PP P    P P P  A   PS P+ +P+  R     P+     
Sbjct: 554 PPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTS 613

Query: 613 LSGDL-SSMPGPGTLSVRVSPPQPILSRGRP 642
           L+ +L    P P        PP P  S  RP
Sbjct: 614 LTRELPPPPPAPPPPPAPSPPPAPATSSRRP 644



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 67/225 (29%), Positives = 83/225 (36%), Gaps = 46/225 (20%)

Query: 379 PEDPKPRLPP---PPVP--PPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFS- 432
           P+ PK  + P   PP+   PP+   P P   P   P PP    P+      +  EP F  
Sbjct: 552 PKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRW 611

Query: 433 --------PRFPFPTVPPAPGVSPLPAPAAFPP----TPQSVPS---------------- 464
                   P  P P  PPAP   P PA ++  P     PQ  PS                
Sbjct: 612 TSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPL 671

Query: 465 -----PAPTPFPIELLPLGYSEPAFGPC--FSMPRGKPPAPSPRGQKASPPTLAPATASP 517
                P P P P +  P      A G     S+PR  P   +P   + SP   APA ++ 
Sbjct: 672 GAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHG-APALSNG 730

Query: 518 PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVP 562
           P T       L  L T   P QAL PP      L+ P SPQ+  P
Sbjct: 731 PQTQAQLLQPLQALQTQLLP-QALPPP---QPQLQPPPSPQQMPP 771



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 63/238 (26%), Positives = 84/238 (35%), Gaps = 29/238 (12%)

Query: 381 DPKPRLPP-----PPVPPPLLHYPPPAKVPGLEPCPP-PPFPPMAP-PTALLQEEPLFSP 433
           D  P  PP     P + PP+   PP  + P   P PP  P PP  P P    +   L  P
Sbjct: 548 DEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREP 607

Query: 434 RFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPC------ 487
            F + ++        LP P   PP P + PSP P P      PL    P F P       
Sbjct: 608 TFRWTSL-----TRELPPPPPAPPPPPA-PSPPPAPATSSRRPLLLRAPQFTPSEAHLKI 661

Query: 488 FSMPRGKPPAPSPRGQKASPPTLAPATASP-PTTAGSNN----PCLTQLLTAAKPEQALE 542
           +      PP  +P   +  PP    + A P P   G  N    P    ++T   P +A  
Sbjct: 662 YESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTT--PVKAEV 719

Query: 543 PPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAER 600
            P  +  L   P +  + +           P   PP   P P    P  P  +P  E+
Sbjct: 720 SPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPP---PQPQLQPPPSPQQMPPLEK 774



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 86/333 (25%), Positives = 113/333 (33%), Gaps = 75/333 (22%)

Query: 382 PKPRLPPPPVP---PPLLHYPPPAKVPGLEPCPPPPF----------PPMAPPTALLQEE 428
           P P  PPPP P   PPL   PPP      E  PPP            PP+ P     +E 
Sbjct: 425 PPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREA 484

Query: 429 PLFSPRF---PFPTVPPAPGVSPLPAPAAFPP-------------------------TPQ 460
               P     P PT   A G  P  +P   P                          TP+
Sbjct: 485 ARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPR 544

Query: 461 S-VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAP------A 513
             +    P P  +E+ P+    P       +P+   P PSP      P T  P      +
Sbjct: 545 RFMDEDPPKPPKVEVSPV--LRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRS 602

Query: 514 TASPPTTAGSNNPCLTQLLT----AAKPEQALEPPLVSSTLLRSP---GSPQETVPEFPC 566
               PT   ++   LT+ L     A  P  A  PP   +T  R P    +PQ T  E   
Sbjct: 603 ILREPTFRWTS---LTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHL 659

Query: 567 TFL------PPTPAPTPPRPPPGPATLAPS--RPLLVPKAERLSPP-------APSGSER 611
                    PP  AP  P P P PA  +P+   P  V +   LS P        P  +E 
Sbjct: 660 KIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEV 719

Query: 612 RLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDS 644
              G  +   GP T +  + P Q + ++  P +
Sbjct: 720 SPHGAPALSNGPQTQAQLLQPLQALQTQLLPQA 752



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 55/191 (28%), Positives = 78/191 (40%), Gaps = 29/191 (15%)

Query: 395  LLHYPPPA-KVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPA 453
            ++H P P+ + PG E   PP    +  P A  +  P+ +     P + P  G +P PAP 
Sbjct: 1804 IVHSPAPSSEPPGGED--PPLDTDVLVPGAPERHSPIQNLD---PPLRPDSGSAPPPAPR 1858

Query: 454  AFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLA-P 512
            +F      VP+ +P+  P+          +FGP        P   SP       PT+  P
Sbjct: 1859 SFSGARIKVPNYSPSRRPL-------GGVSFGPL-------PSPGSPSSLTHHIPTVGDP 1904

Query: 513  ATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCT---FL 569
               +PP  +   +P    L     P +   PPL +S  LR P  P   V     T     
Sbjct: 1905 DFPAPPRRSRRPSP----LAPRPPPSRWASPPLKTSPQLRVP-PPTSVVTALTPTSGELA 1959

Query: 570  PPTPAPTPPRP 580
            PP PAP+PP P
Sbjct: 1960 PPGPAPSPPPP 1970



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 96/385 (24%), Positives = 126/385 (32%), Gaps = 69/385 (17%)

Query: 276  VGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGT 335
            V +A  + P  TP  P ++    + D  T+S       P     PPS  P V      G 
Sbjct: 2041 VVSAPGLAPSATPGAPRIEQLDGVDDG-TDSEAEAVQQPRGQGTPPS-GPGVVRAGVLGA 2098

Query: 336  LGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLP-------EDPKPRLPP 388
             G    P     + +          +  GP D  A    + L P         P   L  
Sbjct: 2099 AGDRARPPEDLPSEIVDF----VLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTA 2154

Query: 389  PPVPPPL----LHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAP 444
             P  P      L   P  +V  L P P PP P  +    + +   +F        V  A 
Sbjct: 2155 SPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVF--------VKMAG 2206

Query: 445  GVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFG--PCFSMPRGKPPAPSP-- 500
               P+P P   PP P ++   APT +    LP G   P  G  P   + R  PP P P  
Sbjct: 2207 EGEPVPPPVKQPPLPPTISPTAPTSW---TLPPG---PLLGVLPVVGVVRPAPPPPPPPL 2260

Query: 501  ----RGQKASPPTLAP--------ATASPPT-------------TAGSNNPCLTQLLTAA 535
                    ASPP  A         +  SPP               A  + P +  L +  
Sbjct: 2261 TLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGG 2320

Query: 536  KPEQALEPPLVSSTL-LRSPGSP---QETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
                 ++ P V   L L  PG P   +   P    + L P P   PP+ P GP  L    
Sbjct: 2321 FSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDL---- 2376

Query: 592  PLLVPKAERLSPPAPSGSERRLSGD 616
             LL  +    S  A S  E   S D
Sbjct: 2377 -LLESQWHHYSGEASSSEEEPPSPD 2400



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 53/182 (29%), Positives = 73/182 (40%), Gaps = 15/182 (8%)

Query: 462  VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTA 521
            V SPAP+  P      G  +P       +P G P   SP  Q   PP    + ++PP   
Sbjct: 1805 VHSPAPSSEPP-----GGEDPPLDTDVLVP-GAPERHSPI-QNLDPPLRPDSGSAPPPAP 1857

Query: 522  GSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP 581
             S +    ++   +   + L    VS   L SPGSP       P    P  PA  PPR  
Sbjct: 1858 RSFSGARIKVPNYSPSRRPLGG--VSFGPLPSPGSPSSLTHHIPTVGDPDFPA--PPRRS 1913

Query: 582  PGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGR 641
              P+ LAP RP   P +   SPP  +  + R+    S +      S  ++PP P  S   
Sbjct: 1914 RRPSPLAP-RP---PPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPP 1969

Query: 642  PD 643
            P+
Sbjct: 1970 PE 1971



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 20/95 (21%)

Query: 554 PGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRL 613
           P + +E     P    PP P+P PP PPP   + +P  PL  P    +SPP         
Sbjct: 392 PAAEKEEAKLPPPPLTPPAPSPPPPLPPP---STSPPPPLCPPPPPPVSPP--------- 439

Query: 614 SGDLSSMPGPGTLSVRVSPPQPIL------SRGRP 642
              L S P P     +   P P++       RGRP
Sbjct: 440 --PLPSPPPPPAQEEQEESPPPVVPATCSRKRGRP 472



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 49/180 (27%), Positives = 63/180 (35%), Gaps = 29/180 (16%)

Query: 305  NSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPG 364
            N  +   P PS+ P P    P +D+      L P  P   S + +L    R  +  S P 
Sbjct: 1801 NQTIVHSPAPSSEP-PGGEDPPLDT----DVLVPGAPERHSPIQNLDPPLRPDS-GSAPP 1854

Query: 365  PLDSSAFLSSDFLLPEDPKPR----------LPPPPVPPPLLHYPPPAKVPGLEPCP--- 411
            P   S F  +   +P     R          LP P  P  L H+ P    P     P   
Sbjct: 1855 PAPRS-FSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRS 1913

Query: 412  --PPPFPPMAPPTALLQEEPLFSP--RFPFPT-----VPPAPGVSPLPAPAAFPPTPQSV 462
              P P  P  PP+         SP  R P PT     + P  G    P PA  PP P+ +
Sbjct: 1914 RRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDL 1973



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 18/139 (12%)

Query: 318  PEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSS-DF 376
            P+  S  P     FS   +  +VP  S +   L G S         GPL S    SS   
Sbjct: 1847 PDSGSAPPPAPRSFSGARI--KVPNYSPSRRPLGGVSF--------GPLPSPGSPSSLTH 1896

Query: 377  LLPEDPKPRLPPPPV----PPPLLHYPPPAK--VPGLEPCPPPPFPP-MAPPTALLQEEP 429
             +P    P  P PP     P PL   PPP++   P L+  P    PP  +  TAL     
Sbjct: 1897 HIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSG 1956

Query: 430  LFSPRFPFPTVPPAPGVSP 448
              +P  P P+ PP   + P
Sbjct: 1957 ELAPPGPAPSPPPPEDLGP 1975


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 115/424 (27%), Positives = 149/424 (35%), Gaps = 76/424 (17%)

Query: 262  SGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPP 321
            + P PL    E++    A     +L  L P +     + D F  S  P    PS FP   
Sbjct: 721  TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST 780

Query: 322  SFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPED 381
               P   S       GP  P   S  T L     +Q R   PGP            +P  
Sbjct: 781  GPGPHYLS-------GPLPPGTYSGPTQL-----IQPR--APGP----------HAMPVA 816

Query: 382  PKPRLPPPPVPPPLLHYPPPAKVP---------GLEPCPPPPFPPMAPPTALLQEEPLFS 432
            P P L P P   P L   P +            G+ P PP    P APP      E   +
Sbjct: 817  PGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMA 876

Query: 433  PR----------FPFPT-VPPAPGVSPLPAPAAFP-------PTPQSVPSPAPTPFPIEL 474
             R           P P+   P P  +P P P  FP       PTP + P+ A  P P + 
Sbjct: 877  VRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQH 936

Query: 475  -----LPLGYSEPAFGPCFSMPRGKPPAPSPRGQKA---SPPTLAPATASP---PTTAGS 523
                 +P G+  P  GP    P+   P P P   +A    PP        P   P  A  
Sbjct: 937  HFSSGIPAGFPAPRIGP---QPQ---PHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPG 990

Query: 524  NNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPG 583
              P  +    A +P    +PP    T L  PG  Q+ +P        P+P P  P  PP 
Sbjct: 991  LLPPQSPYPYAPQPGVLGQPPPPLHTQLY-PGPAQDPLPAHSGALPFPSPGPPQPPHPPL 1049

Query: 584  PATLAPSRPLLVPKAERLSPPAPSGSER-----RLSGDLSSMPGPGTLSVR--VSPPQPI 636
                APS   + P+A  L+   PS + +      L    +  PGPG +  R   + P P 
Sbjct: 1050 AYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPC 1109

Query: 637  LSRG 640
            L RG
Sbjct: 1110 LRRG 1113



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 111/422 (26%), Positives = 146/422 (34%), Gaps = 76/422 (18%)

Query: 260  TQSGPSPLQLP---PEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSN 316
            + +GP P  L    P   Y G   +IQP                       +P  P P+ 
Sbjct: 778  SSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHA----------------MPVAPGPAL 821

Query: 317  FPEP---------PSFSP---VVDSLFSSGTLGPEVPPA---SSAMTHLSGHSRLQARNS 361
            +P P         P  SP   VV S +    +GP  P A   S+     SG     A   
Sbjct: 822  YPAPAYTPELGLVPRSSPQHGVVSSPYVG--VGPAPPVAGLPSAPPPQFSGPELAMAVRP 879

Query: 362  CPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPP 421
                +DS         +P    PR  P P PPP     P   VP  +P P P   P    
Sbjct: 880  ATTTVDSI-----QAPIPSHTAPRPNPTPAPPP-----PCFPVPPPQPLPTPYTYPAGAK 929

Query: 422  TALLQEEPLFS---PRFPFPTVPPAPGVSPLPAPA-AFPPTPQSVPSPAPTP--FPIE-- 473
              +  +    S     FP P + P P   P P P+ AF P P   P P   P  FP +  
Sbjct: 930  QPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAP 989

Query: 474  -LLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASP---PTLAPATASPPTTAGSNNPCLT 529
             LLP     P + P   +  G+PP P        P   P  A + A P  + G   P   
Sbjct: 990  GLLPPQSPYP-YAPQPGV-LGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHP 1047

Query: 530  QLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAP 589
             L     P      P  +   +R P S  ++ P      L P+PAP+P   P  P   A 
Sbjct: 1048 PLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPS---PHLVPSPAPSPGPGPVPPRPPAA 1104

Query: 590  SRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTEN 649
              P  + +    +    S  E +  G  S  PG G         QP+L   + D+   E 
Sbjct: 1105 EPPPCLRRGAAAADLLSSSPESQHGGTQS--PGGG---------QPLLQPTKVDA--AEG 1151

Query: 650  RR 651
            RR
Sbjct: 1152 RR 1153



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 32/92 (34%), Positives = 40/92 (43%), Gaps = 23/92 (25%)

Query: 387  PPPPVPPPLLHYPPPAKVPGLEPCPPP---PFPPMAPPTALLQEEPLFSPRFPFPTVPPA 443
            PP  +  P+   P PA+ PGL P   P   P P  +PP       PL SP      +P A
Sbjct: 1509 PPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPP-------PLSSP------LPEA 1555

Query: 444  PGVSPLPAPAAFPPTPQSVPSPAPTPFPIELL 475
                  P P   PP P++ PS  P    +ELL
Sbjct: 1556 ------PQPKEEPPVPEA-PSSGPPSSSLELL 1580



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 30/86 (34%), Positives = 36/86 (41%), Gaps = 8/86 (9%)

Query: 380  EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
            E P   LP P  PP L    PPA +P   P P    PP++ P   L E P      P P 
Sbjct: 1514 ESPVASLPGPAEPPGL----PPASLPESTPIPSSSPPPLSSP---LPEAPQPKEEPPVPE 1566

Query: 440  VPPA-PGVSPLPAPAAFPPTPQSVPS 464
             P + P  S L   A+  P   S+ S
Sbjct: 1567 APSSGPPSSSLELLASLTPEAFSLDS 1592



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 33/120 (27%), Positives = 46/120 (38%), Gaps = 24/120 (20%)

Query: 544  PLVSSTLLRSPGSPQETVP-----EFPCTFLPPTPAPTPPRPP----------PGPATLA 588
            PL S+++ +    PQ++       + P + +  T A    RPP          PGPA   
Sbjct: 1468 PLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPP 1527

Query: 589  PSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTE 648
               P  +P+    S P PS S   LS  L   P P     +  PP P      P S+  E
Sbjct: 1528 GLPPASLPE----STPIPSSSPPPLSSPLPEAPQP-----KEEPPVPEAPSSGPPSSSLE 1578



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 34/119 (28%), Positives = 43/119 (36%), Gaps = 13/119 (10%)

Query: 491  PRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAK----PEQALEPPLV 546
            P  KP A +   QK   P       S     G + P  +   T AK    P   LE P+ 
Sbjct: 1464 PPCKPLASASISQKNHLPQ-----DSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVA 1518

Query: 547  SST-LLRSPGSPQETVPE---FPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERL 601
            S       PG P  ++PE    P +  PP  +P P  P P      P  P   P +  L
Sbjct: 1519 SLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSL 1577



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 15/156 (9%)

Query: 212  PPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPP 271
            PPP   CK L S+ +      P++      +L  +  +S I  T+  ++   P  L+ P 
Sbjct: 1463 PPP---CKPLASASISQKNHLPQDSQD--LVLGGDVPISSIQATIAKLSIRPPGGLESPV 1517

Query: 272  EDAYVGNADMIQPDLTPLQ-PSLDDFMDISDFFTNSRLPQPPMP---SNFPEPPSFSPVV 327
              +  G A+   P L P   P        S    +S LP+ P P      PE PS  P  
Sbjct: 1518 A-SLPGPAE--PPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPS 1574

Query: 328  DSLFSSGTLGPEVPPASSAM---THLSGHSRLQARN 360
             SL    +L PE     S++     +S H+ LQA N
Sbjct: 1575 SSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHN 1610



 Score = 31.2 bits (69), Expect = 4.1
 Identities = 28/90 (31%), Positives = 37/90 (41%), Gaps = 16/90 (17%)

Query: 449  LPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPP 508
            L +P A  P P   P   P   P E  P+  S P   P  S P   P AP P   K  PP
Sbjct: 1513 LESPVASLPGPAEPPGLPPASLP-ESTPIPSSSP---PPLSSPL--PEAPQP---KEEPP 1563

Query: 509  TLAPATASPPTTAGSNNPCLTQLLTAAKPE 538
                 ++ PP+++        +LL +  PE
Sbjct: 1564 VPEAPSSGPPSSS-------LELLASLTPE 1586


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 74/256 (28%), Positives = 94/256 (36%), Gaps = 31/256 (12%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPG-LEPCPPPPFPPMAPPTALLQEEPLFSPRFPF 437
           P++P P  P  P P       P  K P    P  P P  P  P     +E    +P+ P 
Sbjct: 314 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 373

Query: 438 PTVP--PAPGVSPLPAPAAFPPTPQSVPSPAPTPF------PIELLPLGYSEPA----FG 485
           PT    P+P     PAP      P +   PAPT        P E  P    EPA      
Sbjct: 374 PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE 433

Query: 486 PCFSMPRG------KPPAPSPRGQKASPPTLAPATASP----PTTAGSNNPCLTQLLTAA 535
           P  + P+       K PAP+   + A   T  PA  +P    PTT     P   + LT  
Sbjct: 434 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT 493

Query: 536 KPEQAL----EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
            PE+      E P  ++    +P +P+E  P  P    P TP    P  P  PA   P  
Sbjct: 494 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 553

Query: 592 PLLVPKAERLSPPAPS 607
           P      E    PAP+
Sbjct: 554 PAPTTPKE----PAPT 565



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 101/361 (27%), Positives = 131/361 (36%), Gaps = 47/361 (13%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVP-------PASSAMTHLSGHSRLQARNS 361
           P+ P P+   EP   +P   +  +     P  P       P   A T     +    +  
Sbjct: 415 PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 474

Query: 362 CPGPLDSSAFLSSDFLLPEDPK------PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPF 415
            P     +A  +   L P  P+      P  P P  P  L    P    P     P P  
Sbjct: 475 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 534

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVP--PAPGVSPLPAPAAFPPT-PQSVPSPAPT---- 468
           P  A P    +  P  +P+ P PT P  PAP      AP     T P ++  PAPT    
Sbjct: 535 PKAAAPNTPKEPAPT-TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 593

Query: 469 PFPIELLPLGYSEPAFGPCF----SMPRGKPPA----PSPRGQKASPPTLAPATASPPTT 520
           P P EL P    EP    C     + P+G  P     P+P   K   PT    TA  PTT
Sbjct: 594 PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA--PTT 651

Query: 521 AGSNNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTP---A 574
                P  T     A  E A    + P  +++   +P +P+ET P  P    P TP   A
Sbjct: 652 L--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 709

Query: 575 PTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
           PT P  PP P T   S P    +     P     S    + +LS+ P P  L    SP +
Sbjct: 710 PTTPETPP-PTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKAL--ENSPKE 761

Query: 635 P 635
           P
Sbjct: 762 P 762



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 72/284 (25%), Positives = 97/284 (34%), Gaps = 28/284 (9%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFP 438
           P++P    P  P P  +   P   K P        P  P  P     +E    +P+ P P
Sbjct: 221 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 280

Query: 439 TV--PPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPA-FGPCFSMPRGKP 495
           T    PAP  +         P P +   PAPT  P E  P    EP    P    P  K 
Sbjct: 281 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPTPTTPKEPAPTTKE 339

Query: 496 PA------PSPRGQKASPPTL----APATASPPTTAGSNNPCLT------QLLTAAKPEQ 539
           PA      P+P   K   PT     AP T   P    +  P  T         T + P  
Sbjct: 340 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 399

Query: 540 ALEP-PLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP-------PGPATLAPSR 591
             EP P  + +   +P  P  T  + P    P  PAPT P+ P       P P T     
Sbjct: 400 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 459

Query: 592 PLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
           P    K    +P  P+ +  + +   +      T   +++P  P
Sbjct: 460 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 503



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 65/222 (29%), Positives = 80/222 (36%), Gaps = 14/222 (6%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
           ++P P  P  P P      P   K P        P  P  P     +E    +P+ P PT
Sbjct: 378 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 437

Query: 440 VP--PAPGVSPLPAPAA-FPPTPQSVPSPAPTPFPIELLPLGYSEPA------FGPCFSM 490
            P  PAP     PAP     P P +   PAPT  P E  P    E A        P  + 
Sbjct: 438 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT-PKEPAPTTPKETAPTTPKKLTP--TT 494

Query: 491 PRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTL 550
           P    P    +    +P  LAP T   PT      P  T    AA P    EP   ++  
Sbjct: 495 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPA-PTTPK 552

Query: 551 LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
             +P +P+E  P  P    P TP  T P     PA   P +P
Sbjct: 553 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 594



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 86/345 (24%), Positives = 114/345 (33%), Gaps = 37/345 (10%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQ-----ARNSCP 363
           P+ P P+   EP   +P   +  ++    P  P   +  T  S  +  +        S P
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 412

Query: 364 GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP-----PPPFPPM 418
                 +  ++    P  PK   P  P  P       PA     EP P     P P  P 
Sbjct: 413 TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPK 472

Query: 419 APPTALLQEEPLFSPRFPFPTVPP--APGVSPLPAPAA---------FPPTPQSVPSPAP 467
            P     +E    +P+   PT P   AP     PAP             PTP +   PAP
Sbjct: 473 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 532

Query: 468 TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTL----APATASPPTTAGS 523
           T  P    P    EPA           P  P+P   K + PT     AP T   P     
Sbjct: 533 TT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 591

Query: 524 NNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             P   +L      E      + P  ++    +P +P+E  P  P    P TP  T P  
Sbjct: 592 KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 651

Query: 581 PPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
              PA   P +P   PK   L+P    G     +   S  P P T
Sbjct: 652 LKEPAPTTPKKP--APK--ELAPTTTKGP----TSTTSDKPAPTT 688



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 67/217 (30%), Positives = 78/217 (35%), Gaps = 43/217 (19%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPC--PPPPFPPMAPPTALLQEEPLFSPRFPF 437
           ++P P  P  P P  L   P   K P    C  P P  P    PT   +  P  +P+ P 
Sbjct: 584 KEPAPTTPKKPAPKELA--PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT-TPKEPA 640

Query: 438 PTVP----------PAPGVSPLPAPAAFPPTPQSVPS------PAPTPFPIELLPLGYSE 481
           PT P          PAP     PAP    PT    P+      PAPT  P E  P    E
Sbjct: 641 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT-PKETAPTTPKE 699

Query: 482 PAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQAL 541
           PA           P  P P   + S PT    T   PTT   +    T  L+A    +AL
Sbjct: 700 PAPTTPKKPAPTTPETPPPTTSEVSTPT----TTKEPTTIHKSPDESTPELSAEPTPKAL 755

Query: 542 EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
           E             SP+E  P  P T    TPA T P
Sbjct: 756 E------------NSPKE--PGVPTT---KTPAATKP 775



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/246 (24%), Positives = 90/246 (36%), Gaps = 26/246 (10%)

Query: 400 PPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTP 459
           P +KV   +P P        P     +E    +P+ P  T P  P  + + +    P  P
Sbjct: 189 PTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEP 247

Query: 460 QSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPA----PSPRGQKASPPT-LAPAT 514
               + +    P E  P    EPA     + P+   P     P+P   K++P T   PA 
Sbjct: 248 APTTTKSAPTTPKEPAPTTTKEPA----PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 303

Query: 515 ASP----PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLP 570
            +P    PTT     P   +  T   P++    P        +P  P  T P+ P    P
Sbjct: 304 TTPKKPAPTTPKEPAPTTPKEPTPTTPKE--PAPTTKEPAPTTPKEPAPTAPKKPAPTTP 361

Query: 571 PTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTL-SVR 629
             PAPT P+ P    T  PS           +P  P+ +  + +   +  P P T  S  
Sbjct: 362 KEPAPTTPKEPAPTTTKEPS---------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 412

Query: 630 VSPPQP 635
            +P +P
Sbjct: 413 TTPKEP 418


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 74/256 (28%), Positives = 94/256 (36%), Gaps = 31/256 (12%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPG-LEPCPPPPFPPMAPPTALLQEEPLFSPRFPF 437
           P++P P  P  P P       P  K P    P  P P  P  P     +E    +P+ P 
Sbjct: 355 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 414

Query: 438 PTVP--PAPGVSPLPAPAAFPPTPQSVPSPAPTPF------PIELLPLGYSEPA----FG 485
           PT    P+P     PAP      P +   PAPT        P E  P    EPA      
Sbjct: 415 PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE 474

Query: 486 PCFSMPRG------KPPAPSPRGQKASPPTLAPATASP----PTTAGSNNPCLTQLLTAA 535
           P  + P+       K PAP+   + A   T  PA  +P    PTT     P   + LT  
Sbjct: 475 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT 534

Query: 536 KPEQAL----EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
            PE+      E P  ++    +P +P+E  P  P    P TP    P  P  PA   P  
Sbjct: 535 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 594

Query: 592 PLLVPKAERLSPPAPS 607
           P      E    PAP+
Sbjct: 595 PAPTTPKE----PAPT 606



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 101/361 (27%), Positives = 131/361 (36%), Gaps = 47/361 (13%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVP-------PASSAMTHLSGHSRLQARNS 361
           P+ P P+   EP   +P   +  +     P  P       P   A T     +    +  
Sbjct: 456 PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 515

Query: 362 CPGPLDSSAFLSSDFLLPEDPK------PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPF 415
            P     +A  +   L P  P+      P  P P  P  L    P    P     P P  
Sbjct: 516 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 575

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVP--PAPGVSPLPAPAAFPPT-PQSVPSPAPT---- 468
           P  A P    +  P  +P+ P PT P  PAP      AP     T P ++  PAPT    
Sbjct: 576 PKAAAPNTPKEPAPT-TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 634

Query: 469 PFPIELLPLGYSEPAFGPCF----SMPRGKPPA----PSPRGQKASPPTLAPATASPPTT 520
           P P EL P    EP    C     + P+G  P     P+P   K   PT    TA  PTT
Sbjct: 635 PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA--PTT 692

Query: 521 AGSNNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTP---A 574
                P  T     A  E A    + P  +++   +P +P+ET P  P    P TP   A
Sbjct: 693 L--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 750

Query: 575 PTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
           PT P  PP P T   S P    +     P     S    + +LS+ P P  L    SP +
Sbjct: 751 PTTPETPP-PTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKAL--ENSPKE 802

Query: 635 P 635
           P
Sbjct: 803 P 803



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 72/284 (25%), Positives = 97/284 (34%), Gaps = 28/284 (9%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFP 438
           P++P    P  P P  +   P   K P        P  P  P     +E    +P+ P P
Sbjct: 262 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 321

Query: 439 TV--PPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPA-FGPCFSMPRGKP 495
           T    PAP  +         P P +   PAPT  P E  P    EP    P    P  K 
Sbjct: 322 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPTPTTPKEPAPTTKE 380

Query: 496 PA------PSPRGQKASPPTL----APATASPPTTAGSNNPCLT------QLLTAAKPEQ 539
           PA      P+P   K   PT     AP T   P    +  P  T         T + P  
Sbjct: 381 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 440

Query: 540 ALEP-PLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP-------PGPATLAPSR 591
             EP P  + +   +P  P  T  + P    P  PAPT P+ P       P P T     
Sbjct: 441 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 500

Query: 592 PLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
           P    K    +P  P+ +  + +   +      T   +++P  P
Sbjct: 501 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 544



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 65/222 (29%), Positives = 80/222 (36%), Gaps = 14/222 (6%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
           ++P P  P  P P      P   K P        P  P  P     +E    +P+ P PT
Sbjct: 419 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 478

Query: 440 VP--PAPGVSPLPAPAA-FPPTPQSVPSPAPTPFPIELLPLGYSEPA------FGPCFSM 490
            P  PAP     PAP     P P +   PAPT  P E  P    E A        P  + 
Sbjct: 479 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT-PKEPAPTTPKETAPTTPKKLTP--TT 535

Query: 491 PRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTL 550
           P    P    +    +P  LAP T   PT      P  T    AA P    EP   ++  
Sbjct: 536 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPA-PTTPK 593

Query: 551 LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
             +P +P+E  P  P    P TP  T P     PA   P +P
Sbjct: 594 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 635



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 86/345 (24%), Positives = 114/345 (33%), Gaps = 37/345 (10%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQ-----ARNSCP 363
           P+ P P+   EP   +P   +  ++    P  P   +  T  S  +  +        S P
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 453

Query: 364 GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP-----PPPFPPM 418
                 +  ++    P  PK   P  P  P       PA     EP P     P P  P 
Sbjct: 454 TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPK 513

Query: 419 APPTALLQEEPLFSPRFPFPTVPP--APGVSPLPAPAA---------FPPTPQSVPSPAP 467
            P     +E    +P+   PT P   AP     PAP             PTP +   PAP
Sbjct: 514 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 573

Query: 468 TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTL----APATASPPTTAGS 523
           T  P    P    EPA           P  P+P   K + PT     AP T   P     
Sbjct: 574 TT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 632

Query: 524 NNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             P   +L      E      + P  ++    +P +P+E  P  P    P TP  T P  
Sbjct: 633 KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 692

Query: 581 PPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
              PA   P +P   PK   L+P    G     +   S  P P T
Sbjct: 693 LKEPAPTTPKKP--APK--ELAPTTTKGP----TSTTSDKPAPTT 729



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 67/217 (30%), Positives = 78/217 (35%), Gaps = 43/217 (19%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPC--PPPPFPPMAPPTALLQEEPLFSPRFPF 437
           ++P P  P  P P  L   P   K P    C  P P  P    PT   +  P  +P+ P 
Sbjct: 625 KEPAPTTPKKPAPKELA--PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT-TPKEPA 681

Query: 438 PTVP----------PAPGVSPLPAPAAFPPTPQSVPS------PAPTPFPIELLPLGYSE 481
           PT P          PAP     PAP    PT    P+      PAPT  P E  P    E
Sbjct: 682 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT-PKETAPTTPKE 740

Query: 482 PAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQAL 541
           PA           P  P P   + S PT    T   PTT   +    T  L+A    +AL
Sbjct: 741 PAPTTPKKPAPTTPETPPPTTSEVSTPT----TTKEPTTIHKSPDESTPELSAEPTPKAL 796

Query: 542 EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
           E             SP+E  P  P T    TPA T P
Sbjct: 797 E------------NSPKE--PGVPTT---KTPAATKP 816



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/246 (24%), Positives = 90/246 (36%), Gaps = 26/246 (10%)

Query: 400 PPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTP 459
           P +KV   +P P        P     +E    +P+ P  T P  P  + + +    P  P
Sbjct: 230 PTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEP 288

Query: 460 QSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPA----PSPRGQKASPPT-LAPAT 514
               + +    P E  P    EPA     + P+   P     P+P   K++P T   PA 
Sbjct: 289 APTTTKSAPTTPKEPAPTTTKEPA----PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 344

Query: 515 ASP----PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLP 570
            +P    PTT     P   +  T   P++    P        +P  P  T P+ P    P
Sbjct: 345 TTPKKPAPTTPKEPAPTTPKEPTPTTPKE--PAPTTKEPAPTTPKEPAPTAPKKPAPTTP 402

Query: 571 PTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTL-SVR 629
             PAPT P+ P    T  PS           +P  P+ +  + +   +  P P T  S  
Sbjct: 403 KEPAPTTPKEPAPTTTKEPS---------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 453

Query: 630 VSPPQP 635
            +P +P
Sbjct: 454 TTPKEP 459


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 74/256 (28%), Positives = 94/256 (36%), Gaps = 31/256 (12%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPG-LEPCPPPPFPPMAPPTALLQEEPLFSPRFPF 437
           P++P P  P  P P       P  K P    P  P P  P  P     +E    +P+ P 
Sbjct: 407 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 466

Query: 438 PTVP--PAPGVSPLPAPAAFPPTPQSVPSPAPTPF------PIELLPLGYSEPA----FG 485
           PT    P+P     PAP      P +   PAPT        P E  P    EPA      
Sbjct: 467 PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE 526

Query: 486 PCFSMPRG------KPPAPSPRGQKASPPTLAPATASP----PTTAGSNNPCLTQLLTAA 535
           P  + P+       K PAP+   + A   T  PA  +P    PTT     P   + LT  
Sbjct: 527 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT 586

Query: 536 KPEQAL----EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
            PE+      E P  ++    +P +P+E  P  P    P TP    P  P  PA   P  
Sbjct: 587 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 646

Query: 592 PLLVPKAERLSPPAPS 607
           P      E    PAP+
Sbjct: 647 PAPTTPKE----PAPT 658



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 101/361 (27%), Positives = 131/361 (36%), Gaps = 47/361 (13%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVP-------PASSAMTHLSGHSRLQARNS 361
           P+ P P+   EP   +P   +  +     P  P       P   A T     +    +  
Sbjct: 508 PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 567

Query: 362 CPGPLDSSAFLSSDFLLPEDPK------PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPF 415
            P     +A  +   L P  P+      P  P P  P  L    P    P     P P  
Sbjct: 568 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 627

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVP--PAPGVSPLPAPAAFPPT-PQSVPSPAPT---- 468
           P  A P    +  P  +P+ P PT P  PAP      AP     T P ++  PAPT    
Sbjct: 628 PKAAAPNTPKEPAPT-TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 686

Query: 469 PFPIELLPLGYSEPAFGPCF----SMPRGKPPA----PSPRGQKASPPTLAPATASPPTT 520
           P P EL P    EP    C     + P+G  P     P+P   K   PT    TA  PTT
Sbjct: 687 PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA--PTT 744

Query: 521 AGSNNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTP---A 574
                P  T     A  E A    + P  +++   +P +P+ET P  P    P TP   A
Sbjct: 745 L--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 802

Query: 575 PTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
           PT P  PP P T   S P    +     P     S    + +LS+ P P  L    SP +
Sbjct: 803 PTTPETPP-PTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKAL--ENSPKE 854

Query: 635 P 635
           P
Sbjct: 855 P 855



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 72/284 (25%), Positives = 97/284 (34%), Gaps = 28/284 (9%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFP 438
           P++P    P  P P  +   P   K P        P  P  P     +E    +P+ P P
Sbjct: 314 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 373

Query: 439 TV--PPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPA-FGPCFSMPRGKP 495
           T    PAP  +         P P +   PAPT  P E  P    EP    P    P  K 
Sbjct: 374 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPTPTTPKEPAPTTKE 432

Query: 496 PA------PSPRGQKASPPTL----APATASPPTTAGSNNPCLT------QLLTAAKPEQ 539
           PA      P+P   K   PT     AP T   P    +  P  T         T + P  
Sbjct: 433 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 492

Query: 540 ALEP-PLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP-------PGPATLAPSR 591
             EP P  + +   +P  P  T  + P    P  PAPT P+ P       P P T     
Sbjct: 493 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 552

Query: 592 PLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
           P    K    +P  P+ +  + +   +      T   +++P  P
Sbjct: 553 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 596



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 65/222 (29%), Positives = 80/222 (36%), Gaps = 14/222 (6%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
           ++P P  P  P P      P   K P        P  P  P     +E    +P+ P PT
Sbjct: 471 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530

Query: 440 VP--PAPGVSPLPAPAA-FPPTPQSVPSPAPTPFPIELLPLGYSEPA------FGPCFSM 490
            P  PAP     PAP     P P +   PAPT  P E  P    E A        P  + 
Sbjct: 531 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT-PKEPAPTTPKETAPTTPKKLTP--TT 587

Query: 491 PRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTL 550
           P    P    +    +P  LAP T   PT      P  T    AA P    EP   ++  
Sbjct: 588 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPA-PTTPK 645

Query: 551 LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
             +P +P+E  P  P    P TP  T P     PA   P +P
Sbjct: 646 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 687



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 86/345 (24%), Positives = 114/345 (33%), Gaps = 37/345 (10%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQ-----ARNSCP 363
           P+ P P+   EP   +P   +  ++    P  P   +  T  S  +  +        S P
Sbjct: 446 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 505

Query: 364 GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP-----PPPFPPM 418
                 +  ++    P  PK   P  P  P       PA     EP P     P P  P 
Sbjct: 506 TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPK 565

Query: 419 APPTALLQEEPLFSPRFPFPTVPP--APGVSPLPAPAA---------FPPTPQSVPSPAP 467
            P     +E    +P+   PT P   AP     PAP             PTP +   PAP
Sbjct: 566 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 625

Query: 468 TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTL----APATASPPTTAGS 523
           T  P    P    EPA           P  P+P   K + PT     AP T   P     
Sbjct: 626 TT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 684

Query: 524 NNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             P   +L      E      + P  ++    +P +P+E  P  P    P TP  T P  
Sbjct: 685 KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 744

Query: 581 PPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
              PA   P +P   PK   L+P    G     +   S  P P T
Sbjct: 745 LKEPAPTTPKKP--APK--ELAPTTTKGP----TSTTSDKPAPTT 781



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 67/217 (30%), Positives = 78/217 (35%), Gaps = 43/217 (19%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPC--PPPPFPPMAPPTALLQEEPLFSPRFPF 437
           ++P P  P  P P  L   P   K P    C  P P  P    PT   +  P  +P+ P 
Sbjct: 677 KEPAPTTPKKPAPKELA--PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT-TPKEPA 733

Query: 438 PTVP----------PAPGVSPLPAPAAFPPTPQSVPS------PAPTPFPIELLPLGYSE 481
           PT P          PAP     PAP    PT    P+      PAPT  P E  P    E
Sbjct: 734 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT-PKETAPTTPKE 792

Query: 482 PAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQAL 541
           PA           P  P P   + S PT    T   PTT   +    T  L+A    +AL
Sbjct: 793 PAPTTPKKPAPTTPETPPPTTSEVSTPT----TTKEPTTIHKSPDESTPELSAEPTPKAL 848

Query: 542 EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
           E             SP+E  P  P T    TPA T P
Sbjct: 849 E------------NSPKE--PGVPTT---KTPAATKP 868



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/246 (24%), Positives = 90/246 (36%), Gaps = 26/246 (10%)

Query: 400 PPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTP 459
           P +KV   +P P        P     +E    +P+ P  T P  P  + + +    P  P
Sbjct: 282 PTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEP 340

Query: 460 QSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPA----PSPRGQKASPPT-LAPAT 514
               + +    P E  P    EPA     + P+   P     P+P   K++P T   PA 
Sbjct: 341 APTTTKSAPTTPKEPAPTTTKEPA----PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 396

Query: 515 ASP----PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLP 570
            +P    PTT     P   +  T   P++    P        +P  P  T P+ P    P
Sbjct: 397 TTPKKPAPTTPKEPAPTTPKEPTPTTPKE--PAPTTKEPAPTTPKEPAPTAPKKPAPTTP 454

Query: 571 PTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTL-SVR 629
             PAPT P+ P    T  PS           +P  P+ +  + +   +  P P T  S  
Sbjct: 455 KEPAPTTPKEPAPTTTKEPS---------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 505

Query: 630 VSPPQP 635
            +P +P
Sbjct: 506 TTPKEP 511


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 74/256 (28%), Positives = 94/256 (36%), Gaps = 31/256 (12%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPG-LEPCPPPPFPPMAPPTALLQEEPLFSPRFPF 437
           P++P P  P  P P       P  K P    P  P P  P  P     +E    +P+ P 
Sbjct: 448 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPA 507

Query: 438 PTVP--PAPGVSPLPAPAAFPPTPQSVPSPAPTPF------PIELLPLGYSEPA----FG 485
           PT    P+P     PAP      P +   PAPT        P E  P    EPA      
Sbjct: 508 PTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKE 567

Query: 486 PCFSMPRG------KPPAPSPRGQKASPPTLAPATASP----PTTAGSNNPCLTQLLTAA 535
           P  + P+       K PAP+   + A   T  PA  +P    PTT     P   + LT  
Sbjct: 568 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPT 627

Query: 536 KPEQAL----EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
            PE+      E P  ++    +P +P+E  P  P    P TP    P  P  PA   P  
Sbjct: 628 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 687

Query: 592 PLLVPKAERLSPPAPS 607
           P      E    PAP+
Sbjct: 688 PAPTTPKE----PAPT 699



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 101/361 (27%), Positives = 131/361 (36%), Gaps = 47/361 (13%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVP-------PASSAMTHLSGHSRLQARNS 361
           P+ P P+   EP   +P   +  +     P  P       P   A T     +    +  
Sbjct: 549 PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 608

Query: 362 CPGPLDSSAFLSSDFLLPEDPK------PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPF 415
            P     +A  +   L P  P+      P  P P  P  L    P    P     P P  
Sbjct: 609 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTT 668

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVP--PAPGVSPLPAPAAFPPT-PQSVPSPAPT---- 468
           P  A P    +  P  +P+ P PT P  PAP      AP     T P ++  PAPT    
Sbjct: 669 PKAAAPNTPKEPAPT-TPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKK 727

Query: 469 PFPIELLPLGYSEPAFGPCF----SMPRGKPPA----PSPRGQKASPPTLAPATASPPTT 520
           P P EL P    EP    C     + P+G  P     P+P   K   PT    TA  PTT
Sbjct: 728 PAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTA--PTT 785

Query: 521 AGSNNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTP---A 574
                P  T     A  E A    + P  +++   +P +P+ET P  P    P TP   A
Sbjct: 786 L--KEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 843

Query: 575 PTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQ 634
           PT P  PP P T   S P    +     P     S    + +LS+ P P  L    SP +
Sbjct: 844 PTTPETPP-PTTSEVSTPTTTKE-----PTTIHKSPDESTPELSAEPTPKAL--ENSPKE 895

Query: 635 P 635
           P
Sbjct: 896 P 896



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 72/284 (25%), Positives = 97/284 (34%), Gaps = 28/284 (9%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFP 438
           P++P    P  P P  +   P   K P        P  P  P     +E    +P+ P P
Sbjct: 355 PKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAP 414

Query: 439 TV--PPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPA-FGPCFSMPRGKP 495
           T    PAP  +         P P +   PAPT  P E  P    EP    P    P  K 
Sbjct: 415 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT-PKEPAPTTPKEPTPTTPKEPAPTTKE 473

Query: 496 PA------PSPRGQKASPPTL----APATASPPTTAGSNNPCLT------QLLTAAKPEQ 539
           PA      P+P   K   PT     AP T   P    +  P  T         T + P  
Sbjct: 474 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 533

Query: 540 ALEP-PLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP-------PGPATLAPSR 591
             EP P  + +   +P  P  T  + P    P  PAPT P+ P       P P T     
Sbjct: 534 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 593

Query: 592 PLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
           P    K    +P  P+ +  + +   +      T   +++P  P
Sbjct: 594 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTP 637



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 65/222 (29%), Positives = 80/222 (36%), Gaps = 14/222 (6%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPT 439
           ++P P  P  P P      P   K P        P  P  P     +E    +P+ P PT
Sbjct: 512 KEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571

Query: 440 VP--PAPGVSPLPAPAA-FPPTPQSVPSPAPTPFPIELLPLGYSEPA------FGPCFSM 490
            P  PAP     PAP     P P +   PAPT  P E  P    E A        P  + 
Sbjct: 572 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT-PKEPAPTTPKETAPTTPKKLTP--TT 628

Query: 491 PRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTL 550
           P    P    +    +P  LAP T   PT      P  T    AA P    EP   ++  
Sbjct: 629 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA-PNTPKEPA-PTTPK 686

Query: 551 LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRP 592
             +P +P+E  P  P    P TP  T P     PA   P +P
Sbjct: 687 EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKP 728



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 86/345 (24%), Positives = 114/345 (33%), Gaps = 37/345 (10%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQ-----ARNSCP 363
           P+ P P+   EP   +P   +  ++    P  P   +  T  S  +  +        S P
Sbjct: 487 PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 546

Query: 364 GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP-----PPPFPPM 418
                 +  ++    P  PK   P  P  P       PA     EP P     P P  P 
Sbjct: 547 TTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPK 606

Query: 419 APPTALLQEEPLFSPRFPFPTVPP--APGVSPLPAPAA---------FPPTPQSVPSPAP 467
            P     +E    +P+   PT P   AP     PAP             PTP +   PAP
Sbjct: 607 EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAP 666

Query: 468 TPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTL----APATASPPTTAGS 523
           T  P    P    EPA           P  P+P   K + PT     AP T   P     
Sbjct: 667 TT-PKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 725

Query: 524 NNPCLTQLLTAAKPEQA---LEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             P   +L      E      + P  ++    +P +P+E  P  P    P TP  T P  
Sbjct: 726 KKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTT 785

Query: 581 PPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGT 625
              PA   P +P   PK   L+P    G     +   S  P P T
Sbjct: 786 LKEPAPTTPKKP--APK--ELAPTTTKGP----TSTTSDKPAPTT 822



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 67/217 (30%), Positives = 78/217 (35%), Gaps = 43/217 (19%)

Query: 380 EDPKPRLPPPPVPPPLLHYPPPAKVPGLEPC--PPPPFPPMAPPTALLQEEPLFSPRFPF 437
           ++P P  P  P P  L   P   K P    C  P P  P    PT   +  P  +P+ P 
Sbjct: 718 KEPAPTTPKKPAPKELA--PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT-TPKEPA 774

Query: 438 PTVP----------PAPGVSPLPAPAAFPPTPQSVPS------PAPTPFPIELLPLGYSE 481
           PT P          PAP     PAP    PT    P+      PAPT  P E  P    E
Sbjct: 775 PTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTT-PKETAPTTPKE 833

Query: 482 PAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQAL 541
           PA           P  P P   + S PT    T   PTT   +    T  L+A    +AL
Sbjct: 834 PAPTTPKKPAPTTPETPPPTTSEVSTPT----TTKEPTTIHKSPDESTPELSAEPTPKAL 889

Query: 542 EPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPP 578
           E             SP+E  P  P T    TPA T P
Sbjct: 890 E------------NSPKE--PGVPTT---KTPAATKP 909



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/246 (24%), Positives = 90/246 (36%), Gaps = 26/246 (10%)

Query: 400 PPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTP 459
           P +KV   +P P        P     +E    +P+ P  T P  P  + + +    P  P
Sbjct: 323 PTSKVLA-KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEP 381

Query: 460 QSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPA----PSPRGQKASPPT-LAPAT 514
               + +    P E  P    EPA     + P+   P     P+P   K++P T   PA 
Sbjct: 382 APTTTKSAPTTPKEPAPTTTKEPA----PTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAP 437

Query: 515 ASP----PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLP 570
            +P    PTT     P   +  T   P++    P        +P  P  T P+ P    P
Sbjct: 438 TTPKKPAPTTPKEPAPTTPKEPTPTTPKE--PAPTTKEPAPTTPKEPAPTAPKKPAPTTP 495

Query: 571 PTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTL-SVR 629
             PAPT P+ P    T  PS           +P  P+ +  + +   +  P P T  S  
Sbjct: 496 KEPAPTTPKEPAPTTTKEPS---------PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAP 546

Query: 630 VSPPQP 635
            +P +P
Sbjct: 547 TTPKEP 552


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 98/343 (28%), Positives = 132/343 (38%), Gaps = 58/343 (16%)

Query: 322 SFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNS-CPGPLDSSAFLSSDFLLPE 380
           S  P +  LF+ G   P + PA      ++G    Q   S  P P   +  +S   + P 
Sbjct: 93  STPPTLGDLFAGGF--PVLRPAGQR--DVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPA 148

Query: 381 DPK--------------PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQ 426
            P+              P  P  P PPP    P P       P PPPP PP  P ++ + 
Sbjct: 149 SPRLGNTSEAHGAARTAPPRPNVPAPPP----PTP-------PPPPPPLPPPLPSSSPI- 196

Query: 427 EEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGP 486
           + PL SP  P  T    P V+P P P A PP P   P P PTP P+    +  S+ A  P
Sbjct: 197 KTPLVSPPGPL-TKGNLPVVAP-PVPCAPPPPP---PPPPPTPPPLPPASV-LSDKAVKP 250

Query: 487 CFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLV 546
             + P   PP P P      PP   P   + P               A+  + A EPP  
Sbjct: 251 QLA-PLHLPPIPPP--LPLLPPCGYPGLKAEP---------------ASPAQDAQEPPAP 292

Query: 547 SSTL-LRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPA 605
              L   +  SP+ ++P  P   +  +    PP PP  P+  AP  P         +PPA
Sbjct: 293 PPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAP--PQKAGAQALPAPPA 350

Query: 606 PSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTE 648
           P GS+  L       PG G   +   P  P  S     S+K++
Sbjct: 351 PPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQ 393



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 95/327 (29%), Positives = 116/327 (35%), Gaps = 69/327 (21%)

Query: 308 LPQPPMPSNFPEP-------PSFSPVVDSLFS------SGTLGPEVPPASSAMTHLSGHS 354
           +P PP P+  P P       PS SP+   L S       G L    PP   A        
Sbjct: 171 VPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPP-----P 225

Query: 355 RLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLE------ 408
                   P PL  ++ LS   + P+     LPP P P PLL   PP   PGL+      
Sbjct: 226 PPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLL---PPCGYPGLKAEPASP 282

Query: 409 -------PCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGV-SPLPAPAAFPPTPQ 460
                  P PPPP PP A            SPR   P  PP PGV S    P   PP   
Sbjct: 283 AQDAQEPPAPPPPLPPYAS----------CSPRASLP-APPLPGVNSSSETPPPLPPKSP 331

Query: 461 SVPSPAPTPFPIELLPLGYSEPAFGPCFSMPR-GKPPAPSPRGQKASPPTLAPATASPPT 519
           S  +P P     + LP   + P   P     R G+P A    G K +PP  AP   SP T
Sbjct: 332 SFQAP-PQKAGAQALPAPPAPPGSQPFLQKKRHGRPGA---GGGKLNPPP-APPARSPTT 386

Query: 520 TAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPR 579
              S     +Q  TA  P Q     L + +L          + +F   F   +    PP 
Sbjct: 387 ELSSK----SQQATAWTPTQQPGGQLRNGSL--------HIIDDFESKFTFHSVEDFPP- 433

Query: 580 PPPGPATLAPSRPLLVPKAERLSPPAP 606
               P    P + +   K  R   P P
Sbjct: 434 ----PDEYKPCQKIYPSKIPRSRTPGP 456



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 78/305 (25%), Positives = 110/305 (36%), Gaps = 61/305 (20%)

Query: 382 PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQE-EPLFSPRF----- 435
           P P  PPPP+PPP    PPP   P   P PPP  PP++  T+ L+  +P           
Sbjct: 2   PVPPPPPPPLPPP----PPPLGAP---PPPPPSAPPVSTDTSSLRRADPKGRSALLADIQ 54

Query: 436 --------------PFPTVPPAPGVSPLPAPAA---FPPTPQSVPSPAPTPFPIELLPLG 478
                           P +  + G +     +A      TP ++       FP+ L P G
Sbjct: 55  QGTRLRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPV-LRPAG 113

Query: 479 YSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLT--------- 529
             + A G     P  + P+P    +  S P + PA+     T+ ++    T         
Sbjct: 114 QRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPA 173

Query: 530 -QLLTAAKPEQALEPPLVSSTLLRSP----------GSPQETVPEFPCTFLPPTPAPTPP 578
               T   P   L PPL SS+ +++P          G+     P  PC   PP P P PP
Sbjct: 174 PPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCA-PPPPPPPPPP 232

Query: 579 RPPPGPATLAPSRPLLVPKAERLS-PPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPIL 637
            PPP P     S   + P+   L  PP P          L  +P  G   ++  P  P  
Sbjct: 233 TPPPLPPASVLSDKAVKPQLAPLHLPPIPP--------PLPLLPPCGYPGLKAEPASPAQ 284

Query: 638 SRGRP 642
               P
Sbjct: 285 DAQEP 289


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 103/350 (29%), Positives = 129/350 (36%), Gaps = 62/350 (17%)

Query: 312 PMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRL-QARNSCPGPLDSSA 370
           P P +   P    P        G+L PE P  S A   L+G   L   R + P P   S 
Sbjct: 140 PGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGS- 198

Query: 371 FLSSDFLLPEDPKPRLPPPPVPPPLLHYPP--------PAKVPGLEPCPPPPFPPMAPPT 422
             SS   LP    P   PPP P   L+ P          + VP     PP P    +PP+
Sbjct: 199 --SSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPS 256

Query: 423 ALLQEEPLF--SPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
               + PLF  S     P +PP+  +   P PA+ PP      S A    P+ L PLG +
Sbjct: 257 ----DPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPV-----SSATMHLPLVLGPLGGA 307

Query: 481 EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
               GP      G PP  +     A+     P    P T  G             +  +A
Sbjct: 308 PTVEGP------GAPPFLASSLLSAAAKAQHPPLPPPSTLQG-------------RRPRA 348

Query: 541 LEPPLVSSTLLRSPGSPQETVPEFPCTFL-------PPTP---APTPPRPPPGPATL-AP 589
             P    S+ LR    P +  P  P T         P TP    P  P P P P +L  P
Sbjct: 349 QAPSASHSSSLR----PSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEP 404

Query: 590 SRPLLVPKAERLSPPAPSGSER----RLSGDLSSMPGPGTLSVRVSPPQP 635
           S+P+L      L  P P  S       L G  + +P P TLS   SPPQP
Sbjct: 405 SQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLS-SGSPPQP 453



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 116/433 (26%), Positives = 154/433 (35%), Gaps = 75/433 (17%)

Query: 264 PSPLQLPPEDAYVGNADMIQPDLTPLQ-------PSLDDFMDISDFFTNSRLPQPPMPSN 316
           PSP+   P +     A    P L PL        PS +  + +S       L   P+P +
Sbjct: 488 PSPVLQSPSEGLGMGAGPACP-LPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLS 546

Query: 317 FPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDF 376
             +PP    +  SLF   T G   PP    +    G     A     GP   S  ++S  
Sbjct: 547 LGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGP---SLLVAS-- 601

Query: 377 LLPEDPKPRLPPPPVPP--------PLLHYPPPA----------------KVPGLEPCPP 412
           LLP  P   LPPP  PP        PLL   P A                   GL    P
Sbjct: 602 LLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSP 661

Query: 413 PPFPPM-APPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
             FPP+ APPT +     L +              + L  P+  PP P  + +P P P P
Sbjct: 662 LLFPPLSAPPTLIALNSALLA--------------ATLDPPSGTPPQPCVLSAPQPGP-P 706

Query: 472 IELLPLGYSEPAFGPCFSMP--RGKPP-APSPRGQKASPPTLAPATASP---PTTAGSNN 525
              +    ++P        P   G+PP   SP    +    L+  T+SP   P+      
Sbjct: 707 TSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPG 766

Query: 526 PCLT-QLLTAAKPEQALEPPLVSST-----LLRSPGSPQETVPEFPCTFLPPTPAPTPPR 579
           P L+ QL     P     PPL  ++     LL+S   P E  PE PC  LPP    +   
Sbjct: 767 PLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQ-PEAPC--LPPESPASALE 823

Query: 580 PPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSR 639
           P P      P    L P      PP P     R SG      G G   +     +P  +R
Sbjct: 824 PEPA----RPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGIN-GEARP--AR 876

Query: 640 GRPDSNKTENRRI 652
           GR   ++ E  R+
Sbjct: 877 GRKPGSRREPGRL 889



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 125/491 (25%), Positives = 169/491 (34%), Gaps = 83/491 (16%)

Query: 193 RKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVV------PVLLGDPEEEPGGRQLLDLN 246
           R P R           G  PP      Q F ++       P  L DP    G        
Sbjct: 146 RPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGS------- 198

Query: 247 CFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNS 306
                 S   F    + PSP   PP            P ++   PS +    +      S
Sbjct: 199 ------SSPRFLPRGNAPSPAPPPP------------PAISLNAPSYNWGAALRSSLVPS 240

Query: 307 RLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCP--- 363
            L  PP P     PPS  P+     S     P +PP+++   H    S+    ++     
Sbjct: 241 DLGSPPAPHASSSPPSDPPLFHC--SDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLP 298

Query: 364 ---GPLDSSA---------FLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCP 411
              GPL  +          FL+S  LL    K + PP P P  L    P A+ P      
Sbjct: 299 LVLGPLGGAPTVEGPGAPPFLASS-LLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSS 357

Query: 412 ---PPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFP-PTPQSVPSPA- 466
              P    P  PPT     E    P+ P  + P AP  +P+P P + P P+   +PS   
Sbjct: 358 SLRPSQRRPRRPPTVFRLLEGR-GPQTPRRSRPRAP--APVPQPFSLPEPSQPILPSVLS 414

Query: 467 ----PTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAG 522
               PTP P       +S+ +F    S     PP   P     SPP   P     P+  G
Sbjct: 415 LLGLPTPGP------SHSDGSFNLLGSDAHLPPP---PTLSSGSPPQ--PRHPIQPSLPG 463

Query: 523 SNNPCLTQLLTAAKPEQALEPPLVSSTLLRSP--GSPQETVPEFPCTFLPPTPAPTPPRP 580
           + +  L+ +  A  P  A + P+V S +L+SP  G      P  P   L    A   P P
Sbjct: 464 TTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSP 523

Query: 581 PPGPATLAPSRP-----LLVPKAERLSPPAPSGSERRLSGDLS---SMPGPGTLSVRVSP 632
             G A      P     L +P +    PP+P      L G L+     P P  L      
Sbjct: 524 EQGLALSGAGFPGMLGALPLPLSLGQPPPSPL-LNHSLFGVLTGGGGQPPPEPLLPPPGG 582

Query: 633 PQPILSRGRPD 643
           P P L+ G P+
Sbjct: 583 PGPPLAPGEPE 593


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 70/213 (32%), Positives = 80/213 (37%), Gaps = 40/213 (18%)

Query: 399 PPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAA---- 454
           P   + P   P PPPP+PP  PP A     PL S   P P   P P ++P P P A    
Sbjct: 14  PQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSES 73

Query: 455 -----FPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP---PAPSPRGQKAS 506
                  PTP+    PA  P P         EPA  P    P  +P   PAP P  + A 
Sbjct: 74  ATELYTEPTPEPATEPASEPAP---------EPATEPA-PEPATEPAPEPAPEPATESAP 123

Query: 507 PPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEF-- 564
            PT  PA  S P  A        +L     PE A EP     T L +P    E  PEF  
Sbjct: 124 EPTPEPALESVPEPA-------PELTPEVAPELAPEPTPEPVTEL-APEFCPEAAPEFRP 175

Query: 565 ---PCTFLPPTPA-----PTPPRPPPGPATLAP 589
              PC    P         T P P P P+   P
Sbjct: 176 SPAPCLLQCPVDTRERGLKTSPSPSPSPSPRTP 208



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 70/213 (32%), Positives = 86/213 (40%), Gaps = 39/213 (18%)

Query: 379 PEDPKPRLPPPPVP-----PPLLHYPPPAKVPGLEPCP---PPPFPPMAPPTALLQEEPL 430
           PE P P  PPPP P     PPLL    P  +P  EPCP   P P P     +A      L
Sbjct: 24  PEPPPPWPPPPPPPAPPPAPPLLSEASPEPIP--EPCPELAPGPCPEATSESA----TEL 77

Query: 431 FSPRFPFPTVPPAPGVSPLPAPAAFP-PTPQSVPSPAPTPFP-IELLPLGYSEPAFGPCF 488
           ++   P P   PA    P P PA  P P P + P+P P P P  E  P    EPA     
Sbjct: 78  YTEPTPEPATEPAS--EPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPAL---- 131

Query: 489 SMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALE-PPLVS 547
                  P P+P       P LAP     P         +T+L     PE A E  P  +
Sbjct: 132 ----ESVPEPAPELTPEVAPELAPEPTPEP---------VTELAPEFCPEAAPEFRPSPA 178

Query: 548 STLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP 580
             LL+ P   +E   +   T   P+P+P+P  P
Sbjct: 179 PCLLQCPVDTRERGLK---TSPSPSPSPSPRTP 208



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 63/177 (35%), Positives = 74/177 (41%), Gaps = 17/177 (9%)

Query: 439 TVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAP 498
           T PP  G  P  +P   PP P   P PAP P P  LL     EP   PC  +  G  P P
Sbjct: 11  TAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAP-PLLSEASPEPIPEPCPELAPG--PCP 67

Query: 499 SPRGQKA----SPPTLAPAT--ASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLR 552
               + A    + PT  PAT  AS P    +  P   +  T   PE A E P   S    
Sbjct: 68  EATSESATELYTEPTPEPATEPASEPAPEPATEPA-PEPATEPAPEPAPE-PATESAPEP 125

Query: 553 SPGSPQETVPEFPCTFLPPTPAP-TPPRPPPGPAT-LAPSRPLLVPKAERLSPPAPS 607
           +P    E+VPE P   L P  AP   P P P P T LAP      P+A     P+P+
Sbjct: 126 TPEPALESVPE-PAPELTPEVAPELAPEPTPEPVTELAPE---FCPEAAPEFRPSPA 178



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 64/212 (30%), Positives = 78/212 (36%), Gaps = 30/212 (14%)

Query: 309 PQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDS 368
           P+PP P   P PP   P    L S  +  P   P               A   CP     
Sbjct: 24  PEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPEL-----------APGPCPEATSE 72

Query: 369 SAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEE 428
           SA   ++      P+P   P   P      P PA  P  EP   P   P   P      E
Sbjct: 73  SA---TELYTEPTPEPATEPASEPA-----PEPATEPAPEPATEPAPEPAPEPATESAPE 124

Query: 429 PLFSPRFPFPTVP-PAPGVSPLPAPAAFP-PTPQSVPSPAPTPFPIELLPLGYSEPAFGP 486
           P  +P     +VP PAP ++P  AP   P PTP+ V   AP   P E  P     PA  P
Sbjct: 125 P--TPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEFCP-EAAPEFRPSPA--P 179

Query: 487 CFSMPRGKPPAPSPRGQKASP-PTLAPATASP 517
           C       P     RG K SP P+ +P+  +P
Sbjct: 180 CLLQ---CPVDTRERGLKTSPSPSPSPSPRTP 208



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 5/68 (7%)

Query: 570 PPTPAPTPPRPPPGPATLAPSRPLLVPK-AERLSP-PAPSGSERRLSGDLSSMPGPGTLS 627
           PP P P  P PPP P  L+ + P  +P+    L+P P P  +    + +L + P P   +
Sbjct: 31  PPPPPP--PAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESAT-ELYTEPTPEPAT 87

Query: 628 VRVSPPQP 635
              S P P
Sbjct: 88  EPASEPAP 95


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 70/250 (28%), Positives = 89/250 (35%), Gaps = 40/250 (16%)

Query: 266 PLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSP 325
           P  L  ++  +G  + +     P  P  D     S  F+   LP PP   ++P       
Sbjct: 225 PPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYP------- 277

Query: 326 VVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPR 385
            VD+   SG  GP+     S++   S         S PGP    A             P 
Sbjct: 278 -VDNQRGSGLAGPK----RSSVVSPSHPPPAPPLGSPPGPKPGFA-------------PP 319

Query: 386 LPPPPVPPPLLHYPPPAKVPGLEP--CPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPA 443
             PPP PPP++  PPP    G      PPPP PP  PP           P F  P  PP 
Sbjct: 320 PAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPP----------HPDFAAPPPPPP 369

Query: 444 PGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQ 503
           P  +  P     PP P S P+    P P    P G   P F      P   PP       
Sbjct: 370 PPAADYPT---LPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKP 426

Query: 504 KASPPTLAPA 513
           K+S P ++ A
Sbjct: 427 KSSLPAVSDA 436



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 73/258 (28%), Positives = 87/258 (33%), Gaps = 82/258 (31%)

Query: 360 NSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPP----------PAKVPGLEP 409
           +S P P  S +  S      ED    LPPPP       YP           P +   + P
Sbjct: 244 SSYPPPPQSDSASSPSPSFSED---NLPPPPAE---FSYPVDNQRGSGLAGPKRSSVVSP 297

Query: 410 CPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTP 469
             PPP PP+  P                    P PG +P PAP   PP    +P P P  
Sbjct: 298 SHPPPAPPLGSPPG------------------PKPGFAPPPAPPPPPPPMIGIPPPPP-- 337

Query: 470 FPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLT 529
                 P+G+  P          G PP PSP      P   AP    PP  A  + P L 
Sbjct: 338 ------PVGFGSP----------GTPPPPSPPSFPPHPDFAAPPPPPPPPAA--DYPTLP 379

Query: 530 QLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAP 589
                        PPL   T     G+P            PP P P PP PPP P T A 
Sbjct: 380 P------------PPLSQPT----GGAP------------PPPPPPPPPGPPPPPFTGAD 411

Query: 590 SRPLLVPKAERLSPPAPS 607
            +P + P     + P  S
Sbjct: 412 GQPAIPPPLSDTTKPKSS 429



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 68/261 (26%), Positives = 83/261 (31%), Gaps = 75/261 (28%)

Query: 381 DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTV 440
           + K +L     PP L++      +  +E      +PP  PP +     P  SP F    +
Sbjct: 214 ESKEKLGTSGYPPTLVYQN--GSIGCVENVDASSYPP--PPQSDSASSP--SPSFSEDNL 267

Query: 441 PPAPGVSPLPAP-----AAFPPTPQSVPSPA-PTPFPIELLPLGYSEPAFGPCFSMPRGK 494
           PP P     P           P   SV SP+ P P P    PLG S P   P F+ P   
Sbjct: 268 PPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAP----PLG-SPPGPKPGFAPPPAP 322

Query: 495 PPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSP 554
           PP P P      PP        PP   GS                              P
Sbjct: 323 PPPPPPMIGIPPPP--------PPVGFGS------------------------------P 344

Query: 555 GSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLS 614
           G+P               P P+PP  PP P   AP  P   P A+  + P P      LS
Sbjct: 345 GTP---------------PPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPP-----LS 384

Query: 615 GDLSSMPGPGTLSVRVSPPQP 635
                 P P        PP P
Sbjct: 385 QPTGGAPPPPPPPPPPGPPPP 405


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 75/241 (31%), Positives = 89/241 (36%), Gaps = 15/241 (6%)

Query: 374 SDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSP 433
           SD       + + PP  VPP  +  PP    P L P P PP  P  PPT L    P  +P
Sbjct: 380 SDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAP 439

Query: 434 RFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRG 493
             PF   P  PG+   P P   PP P     P P P P   LP G   P  GP   +P  
Sbjct: 440 --PFLRPPGMPGLRG-PLPRLLPPGPPPGRPPGPPPGPPPGLPPG--PPPRGPPPRLPPP 494

Query: 494 KPPA-PSPRGQKASPPTLAPATASPP---TTAGSNNPCL----TQLLTAAKPEQALEPPL 545
            PP  P PR     PP + P   +PP     A   NP +      L+   K +      +
Sbjct: 495 APPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATI 554

Query: 546 VSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPA 605
                      PQ T P+   T   PT      R     AT AP R      A  L+  A
Sbjct: 555 EKKATATISAKPQITNPKAEITRFVPTALRV--RRENKGATAAPQRKSEDDSAVPLAKAA 612

Query: 606 P 606
           P
Sbjct: 613 P 613



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 51/166 (30%), Positives = 59/166 (35%), Gaps = 34/166 (20%)

Query: 306 SRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGP 365
           S++  PPMP   P  P  +P +        L P  PP +       G   L+      GP
Sbjct: 400 SQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLR------GP 453

Query: 366 LDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALL 425
           L                 PRL PP  PP     PPP   PGL P PPP  PP        
Sbjct: 454 L-----------------PRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPP-------- 488

Query: 426 QEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFP 471
              P   P  P    PP PG+   P      P P  +  PAP P P
Sbjct: 489 ---PRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNP 531



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 50/149 (33%), Positives = 56/149 (37%), Gaps = 12/149 (8%)

Query: 495 PPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSP 554
           PP   P  Q  +PP   P    PP       P     L    P  A  PP      LR P
Sbjct: 393 PPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGA--PPF-----LRPP 445

Query: 555 GSPQETVPEFPCTFLPPTPAP-TPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRL 613
           G P    P  P   LPP P P  PP PPPGP    P  P       RL PPAP G     
Sbjct: 446 GMPGLRGP-LP-RLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPR 503

Query: 614 SGDLSS--MPGPGTLSVRVSPPQPILSRG 640
            G +    +P  G     + PP P+ + G
Sbjct: 504 PGMMRPPLVPPLGPAPPGLFPPAPLPNPG 532



 Score = 33.5 bits (75), Expect = 0.84
 Identities = 24/72 (33%), Positives = 30/72 (41%), Gaps = 17/72 (23%)

Query: 365 PLDSSAFLSSDFLLPEDPKPRLPPPPV--------PP-------PLLHYPPPAKVPGLEP 409
           PL       S+ L+ + P P   PP +        PP       PLL +  P   PG +P
Sbjct: 140 PLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKP 199

Query: 410 CPPPPFPPMAPP 421
             PPP PP  PP
Sbjct: 200 PGPPPGPP--PP 209


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 119/428 (27%), Positives = 153/428 (35%), Gaps = 74/428 (17%)

Query: 260  TQSGPSP-LQLPPEDAYVGNADMIQPDLTPLQPSLDDFM--DISDFFTNSRLPQPPMPSN 316
            T   PSP L   PE   +G      P     Q SL  F+  + S    ++  P   +P++
Sbjct: 662  TTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPAS 721

Query: 317  F---PEPPSFSPVVDSLFSSGT-LGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAF- 371
                  PP+  P   +  + G  LGP+ P  S A    +      A    PGP  S +  
Sbjct: 722  VIVSAPPPAQDPAPATPVAKGAGLGPQAPD-SQASPAPAPQIPAAAPLKGPGPSSSPSLP 780

Query: 372  ----LSSDFLLPEDPKPRLPP--PPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALL 425
                L     LP  P P  PP  PP  P  +  PP    P L PCPPP  PP  P   ++
Sbjct: 781  HQAPLGDSPHLPS-PHPTRPPSRPPSRPQSVSRPPSE--PPLHPCPPPQAPPTLPGIFVI 837

Query: 426  QEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFG 485
            Q +    P    P   PAP     P P   P  PQS P   P P    L P   S     
Sbjct: 838  QNQLGVPP----PASNPAP---TAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVAS 890

Query: 486  PCFSMPRGKPPAPS-----------PRGQKASPPT--LAPATASPPTTAGSNNPCLTQLL 532
               +  R   P PS           P      PPT  L P  A+PP         +T   
Sbjct: 891  SSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPF 950

Query: 533  TA-AKPEQALE--PPLVSSTLLR-----SPGSPQETVPEFPCTF---------LPPTPAP 575
             A  +P+  LE    + S  +L+     +P +PQ +    P T            P+  P
Sbjct: 951  PALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTP 1010

Query: 576  TPPRPPPGPATLAPS--RPLL---------------VPKAERLSPPAPSGSERRLSGDLS 618
            T P   P PA +A +   PLL               V KA    P  PSG +      LS
Sbjct: 1011 TAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQ--YESKLS 1068

Query: 619  SMPGPGTL 626
             +  P TL
Sbjct: 1069 GLKKPPTL 1076



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 77/288 (26%), Positives = 98/288 (34%), Gaps = 71/288 (24%)

Query: 388 PPPVPPPLLHYPP----PAKVPGLEPCPPPPF---PPMAPPTALLQEEPL---------- 430
           PP  P P    PP    P   PGL   P       PP A PTA+L ++ L          
Sbjct: 647 PPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQ 706

Query: 431 --FSPRFPFPTVP-------PAPGVSPLPA-PAAF-----PPTPQSVPSPAPTPFPIELL 475
              S   P  +VP       P P   P PA P A      P  P S  SPAP P      
Sbjct: 707 QPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAA 766

Query: 476 PLGYSEPAFGPCFSMPRGKP-------PAPSPRGQKASPPTLAPATASPPTTAGSNNPCL 528
           PL    P+  P  S+P   P       P+P P    + PP+   + + PP+         
Sbjct: 767 PLKGPGPSSSP--SLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPS--------- 815

Query: 529 TQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPP-PGPATL 587
                        EPPL        P  P +  P  P  F+       PP    P P   
Sbjct: 816 -------------EPPL-------HPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAP 855

Query: 588 APSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQP 635
            P +P L P+++    P P       S   S++      S R+  P P
Sbjct: 856 GPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTP 903



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 86/304 (28%), Positives = 108/304 (35%), Gaps = 77/304 (25%)

Query: 377 LLPEDPKPRLPPP-PVPPPLLHYPPPAKVPGLEPCPPPPFPPM----------------- 418
           +L   P P+ PP    P PL    P A+ P   P P    PP                  
Sbjct: 618 VLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKI 677

Query: 419 -------APPTALLQEEPL------------FSPRFPFPTVP-------PAPGVSPLPA- 451
                  A PTA+L ++ L             S   P  +VP       P P   P PA 
Sbjct: 678 VLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPAT 737

Query: 452 PAA-----FPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKP-------PAPS 499
           P A      P  P S  SPAP P      PL    P+  P  S+P   P       P+P 
Sbjct: 738 PVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSP--SLPHQAPLGDSPHLPSPH 795

Query: 500 PRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQE 559
           P    + PP+  P + S P +    +PC         P QA  PP +    +      Q 
Sbjct: 796 PTRPPSRPPS-RPQSVSRPPSEPPLHPC--------PPPQA--PPTLPGIFVI---QNQL 841

Query: 560 TVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSS 619
            VP  P    P   AP PP+PP  P +  P  PL  P A  L P + S +    S   S 
Sbjct: 842 GVP--PPASNPAPTAPGPPQPPLRPQSQPPEGPL--PPAPHLPPSSTSSAVASSSETSSR 897

Query: 620 MPGP 623
           +P P
Sbjct: 898 LPAP 901



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 77/279 (27%), Positives = 99/279 (35%), Gaps = 31/279 (11%)

Query: 388 PPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVS 447
           P  V  P L   P +   G  P    P P     T +LQ   L          P      
Sbjct: 546 PIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLVQP 605

Query: 448 PLPAPAAFPPTPQSVPSPAPTPFPIEL--LPLGYSEP-AFGP-------CFSMPRGKPPA 497
             PA A     P     PAP   P     LPLG  +P A  P         + P+   P 
Sbjct: 606 ATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQ 665

Query: 498 PSPRGQKASPPTLA---PATASPPTTAGSNNPCLTQLLTAAKPEQAL--EPPLVS---ST 549
           PSP G  +SP  +    P +A+P  TA      L   L   + +Q L  E P +S   S 
Sbjct: 666 PSP-GLASSPEKIVLGQPPSATP--TAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASV 722

Query: 550 LLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGS 609
           ++ +P   Q+  P  P        A   P+ P   A+ AP+    +P A  L  P PS S
Sbjct: 723 IVSAPPPAQDPAPATPVA----KGAGLGPQAPDSQASPAPAPQ--IPAAAPLKGPGPSSS 776

Query: 610 ----ERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDS 644
                +   GD   +P P        PP    S  RP S
Sbjct: 777 PSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPS 815



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 59/226 (26%), Positives = 77/226 (34%), Gaps = 36/226 (15%)

Query: 381  DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSP-RFPFPT 439
            DP  + PPPP            KV    P PPPP PP       +   P  +P R P  T
Sbjct: 1328 DPVHQPPPPPA---------TLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGT 1378

Query: 440  VPPAPGVSPLPAPAAF------PPTPQSVP-------SPAPTPFPIELLPLGYSEPAFGP 486
             P  P    LP    +      P  P+  P       SPAP P  ++    G        
Sbjct: 1379 APHCP---RLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAV 1435

Query: 487  ----CFSMPRGKPPAP-SPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQ-- 539
                   M +G PP P +   Q    P        P     S +P + Q   ++   Q  
Sbjct: 1436 EDELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDD 1495

Query: 540  ALEPPLVSS--TLLRSPGSPQET-VPEFPCTFLPPTPAPTPPRPPP 582
             L   L S+  ++L    +P  T  P +P      TPA  PP   P
Sbjct: 1496 TLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRP 1541



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 112/472 (23%), Positives = 149/472 (31%), Gaps = 106/472 (22%)

Query: 226 VPVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPD 285
           +P L G P   PGG                  T    G +P+Q+  +     N       
Sbjct: 211 IPGLQGLPNGSPGGA-----------------TAATLGLAPIQVVGQPVMALN------- 246

Query: 286 LTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASS 345
            TP    L   + +S +  ++  P  P+          SP    L     L   V    +
Sbjct: 247 -TPTSQLLAKQVPVSGYLASAAGPSEPVTL---ASAGVSPQGAGLVIQKNLSAAVATTLN 302

Query: 346 AMTHLSGHSRLQARNSCPG--PLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAK 403
             +   G     A    P   PL  +  L S  L+P    P +     P P+   P    
Sbjct: 303 GNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPA---PNVILHRTPTPIQPKPAGVL 359

Query: 404 VPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPG---------------VSP 448
            P L    P PF P A  T  +Q EP        P  P AP                +S 
Sbjct: 360 PPKLYQLTPKPFAP-AGATLTIQGEP-----GALPQQPKAPQNLTFMAAGKAGQNVVLSG 413

Query: 449 LPAPA---------------AFPPTPQSVPSPAPTPFPIELLPLGYS--EPAFGPC---- 487
            PAPA               A PP P   P     P  + LL  G S   PA        
Sbjct: 414 FPAPALQANVFKQPPATTTGAAPPQP---PGALSKPMSVHLLNQGSSIVIPAQHMLPGQN 470

Query: 488 -FSMPRGKPPAPSPRGQKASPPTLAP--ATASPPTTAGS--NNPCLT--------QLLTA 534
            F +P G P    P+   A P  +      A+ P T G    NP LT         L   
Sbjct: 471 QFLLP-GAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPV 529

Query: 535 AKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRP-PPGPA-------- 585
             P        + S      G P   + + P + L     PT  +P P GPA        
Sbjct: 530 LAPHSGAHSAHILSAAPIQVGQP--ALFQMPVS-LAAGSLPTQSQPAPAGPAATTVLQGV 586

Query: 586 TLAPSRPLLVPKAERLSPPA-PSGSERRLSGDLSSMPGPGTLSVRVSPPQPI 636
           TL PS   ++   + L  PA P+ +    +  L+  P P      VS P P+
Sbjct: 587 TLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAP-QAPPAVSTPLPL 637



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 41/160 (25%), Positives = 58/160 (36%), Gaps = 17/160 (10%)

Query: 462  VPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPR---------GQKASPPTLAP 512
            V S      PI     G+  P  GP  S   G    P P          G     P++  
Sbjct: 1202 VSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTW 1261

Query: 513  ATASPPTTAGSNNPCLTQLLTAAK--PEQALEPPLVSSTLLRSP-GSPQETVPEFPCTFL 569
            A AS   ++ S++      L A +  P  +   P + +   RS  G   +   E   + +
Sbjct: 1262 ARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKV 1321

Query: 570  PPTPAPTPP-RPPPGPATLAPSRPLLVPKAERLSPPAPSG 608
                A  P  +PPP PATL  + P   P      PP P+G
Sbjct: 1322 VHNTALDPVHQPPPPPATLKVAEPPPRPP----PPPPPTG 1357


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 92/331 (27%), Positives = 118/331 (35%), Gaps = 64/331 (19%)

Query: 299 ISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQA 358
           + + F  +  P  P P   P    F     S FS GT     PP     T  S +S   +
Sbjct: 501 LEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGS 560

Query: 359 RNSCP-GPLDSSAFLSSDFLLPE-DPKPRLPPP---PVPPPLLHYPPPAKVPGLEPCPPP 413
            +S P GP+   +F    +L    DP PR P P   P  PPL+    P  +  L P PP 
Sbjct: 561 HSSSPAGPV---SFPPPPYLARSIDPLPRPPSPAQNPQDPPLV----PLTL-ALPPAPPS 612

Query: 414 PFPPMAPPTALLQEEPLFSPRFPFPTVP---PAPGVSPL-PAPAAFPPTPQSVPSPAPTP 469
                   +    E P   PR  FP  P   P P   PL  AP   PP    +P+  P  
Sbjct: 613 SCHQNTSGSFRRPESP--RPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGELPARGPRL 670

Query: 470 FPIELLPL--GYSEPAFGPCFSMPRG---------------------------KPPAPSP 500
           F     PL   + EPA      +P G                           +PP   P
Sbjct: 671 FDFPPTPLEDQFEEPA--EFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEP 728

Query: 501 RGQKASP-PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQE 559
                SP PT    T + P  A +     T   TA + E+   PP +          P  
Sbjct: 729 FASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPAL---------PPPP 779

Query: 560 TVPEFPCTFLPPTPAPTPPRPPPGPATLAPS 590
            + +FP    PP+    PP PPP PA+L  S
Sbjct: 780 PLAKFP----PPSQPQPPPPPPPSPASLLKS 806



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 112/450 (24%), Positives = 140/450 (31%), Gaps = 149/450 (33%)

Query: 251 DISDTLFTMTQSGPSPLQ--LPPEDAY---------VGNADMIQPDLTPLQPSLDDFMDI 299
           +I + LF  T+  P P    LP  + +         VG  D   P  TP  P+       
Sbjct: 499 EILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPP-TPPTPTTSS---- 553

Query: 300 SDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFS--SGTLGPEVPPASSAMTHLSGHSRLQ 357
           S+  + S    P  P +FP PP  +  +D L    S    P+ PP       L       
Sbjct: 554 SNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALP------ 607

Query: 358 ARNSCPGPLDSS-AFLSSDFLLPEDPKPRLP--------PPPVPPPLLHYPPP------- 401
                P P  S     S  F  PE P+PR+         P P P PL   P P       
Sbjct: 608 -----PAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGVGE 662

Query: 402 --AKVPGLEPCPPPPF-------------------------------------------- 415
             A+ P L   PP P                                             
Sbjct: 663 LPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQ 722

Query: 416 PPMAPPTALLQEEPLFSPRFPFPTVP-----------------------PAPGVSPLPAP 452
           PP+  P A LQ  P  +   P  T P                       P P + P P  
Sbjct: 723 PPLKEPFASLQS-PFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPL 781

Query: 453 AAFPPTPQSVPSPAPTPFPIELLP--------LGYSEPAFGPCFSMPRGKPPAPSPRGQK 504
           A FPP  Q  P P P P P  LL           Y     G   S      P P P  Q 
Sbjct: 782 AKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVS----TRPGPLPTTQ- 836

Query: 505 ASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSP---QETV 561
            SP   + ATA PPT+A            A   + + +P   SS+   + G P   +   
Sbjct: 837 YSPGPPSGATALPPTSA------------APSAQGSPQPSASSSSQFSTSGGPWARERRA 884

Query: 562 PEFPCTFLPPTPAPTPPRPPPGPATLAPSR 591
            E       P P P  P  PP P +L P+R
Sbjct: 885 GE------EPVPGPMTPTQPPPPLSLPPAR 908



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 85/312 (27%), Positives = 104/312 (33%), Gaps = 75/312 (24%)

Query: 311 PPMPSNFPEPPSFSPVVDSLFSSGT------LGPEVPPASSAMT---HLSGHSRL-QARN 360
           P  PS  P  P  +    S  SS T        P +P A    T    +S H RL  + +
Sbjct: 384 PYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAH 443

Query: 361 SCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPP---AKVPGLEPC------- 410
           S   P   +   +    LP  P P  PPPP  P LL  PPP    K P            
Sbjct: 444 SSRKPFLGAPAATPHLSLP--PGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEIL 501

Query: 411 ---------PPPPFPPMAPPTALLQEEPLFSPRFPFPT----VPPAPGVSPLPAPAAFPP 457
                    PP P PP  P        P  + RF   T     PP P     P P     
Sbjct: 502 EELFFGTEGPPRPAPPPLPHREGFLGPP--ASRFSVGTQDSHTPPTP-----PTPTTSSS 554

Query: 458 TPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASP 517
              S    +    P+   P  Y   +  P   +PR   PA +P+     P TLA   A P
Sbjct: 555 NSNSGSHSSSPAGPVSFPPPPYLARSIDP---LPRPPSPAQNPQDPPLVPLTLALPPA-P 610

Query: 518 PTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTP 577
           P++   N                      +S   R P SP+      P    P TP    
Sbjct: 611 PSSCHQN----------------------TSGSFRRPESPR------PRVSFPKTP-EVG 641

Query: 578 PRPPPGPATLAP 589
           P PPPGP + AP
Sbjct: 642 PGPPPGPLSKAP 653



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 107/426 (25%), Positives = 131/426 (30%), Gaps = 117/426 (27%)

Query: 308 LPQPPMPSNFPEPPSFSPVVDSLFSS-----------GTL-----GPE----VPPASSAM 347
           LP PP+P   P PP   P +  L +S            TL     GPE     PP     
Sbjct: 246 LPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQ 305

Query: 348 THLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPP--PPVPPPLLHYPPPAKVP 405
            H   H         P P  + A+ +        P  RL P  PP P P    PP A+  
Sbjct: 306 RHSLPH---------PYPYPAPAYTA------HPPGHRLVPAAPPGPGP---RPPGAESH 347

Query: 406 GLEPCPPPPFPPM----------------APPTALLQEEPLFSPRFPFPTV--------- 440
           G  P   PP   +                A  TA +   P   P  P  T          
Sbjct: 348 GCLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSN 407

Query: 441 ---------PPAPGVSPLPAPA-------AFPPTPQSVPSP---APTPFPIELLPLGYSE 481
                    P  PG      PA          P+  S   P   AP   P   LP G S 
Sbjct: 408 TGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSS 467

Query: 482 PAFGPCFSMPRGKPP-----APSPRGQKASPPTL-----------APATASPPTTAGSNN 525
           P   PC  + R  PP      P+ R  +     L            PA    P   G   
Sbjct: 468 PPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLG 527

Query: 526 PCLTQLLTAAKPEQA-LEPPLVSSTLLRSPGSPQETVPEFPCTFLPP-------TPAPTP 577
           P  ++     +       PP  +++   S      + P  P +F PP        P P P
Sbjct: 528 PPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRP 587

Query: 578 PRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVS-PPQPI 636
           P P        P  P LVP    L P  PS   +  SG   S   P +   RVS P  P 
Sbjct: 588 PSPAQN-----PQDPPLVPLTLALPPAPPSSCHQNTSG---SFRRPESPRPRVSFPKTPE 639

Query: 637 LSRGRP 642
           +  G P
Sbjct: 640 VGPGPP 645



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 59/204 (28%), Positives = 76/204 (37%), Gaps = 40/204 (19%)

Query: 382 PKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQE--EPLFSPRF---- 435
           P P LPPPP   PL  +PPP+     +P PPPP PP   P +LL+     L   ++    
Sbjct: 771 PPPALPPPP---PLAKFPPPS-----QPQPPPPPPP--SPASLLKSLASVLEGQKYCYRG 820

Query: 436 ----------PFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFG 485
                     P PT   +PG  P     A PPT  + PS   +P P       +S    G
Sbjct: 821 TGAAVSTRPGPLPTTQYSPG--PPSGATALPPT-SAAPSAQGSPQPSASSSSQFSTSG-G 876

Query: 486 PCFSMPR-GKPPAPSPRGQKASPP--TLAPATASPPTTAGSNNPCLT-------QLLTAA 535
           P     R G+ P P P      PP  +L PA +        +  C T            A
Sbjct: 877 PWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEISRACETLVERVGRSATDPA 936

Query: 536 KPEQALEPPLVSSTLLRSPGSPQE 559
            P    EP    +  L  P   +E
Sbjct: 937 DPVDTAEPADSGTERLLPPAQAKE 960



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 74/265 (27%), Positives = 90/265 (33%), Gaps = 34/265 (12%)

Query: 384 PRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMA-PPTALLQEEPLFSPRFPFPTVPP 442
           P  PPP  PPP    PPP       P PPPP P +A  P   L +  L+S        P 
Sbjct: 245 PLPPPPLPPPP----PPP-------PPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPE 293

Query: 443 APGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRG 502
             G     AP        S+P P P P P        +  A  P   +    PP P PR 
Sbjct: 294 RKG----SAPPERQEQRHSLPHPYPYPAP--------AYTAHPPGHRLVPAAPPGPGPRP 341

Query: 503 QKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVP 562
             A      PAT  P +    +    +++ ++  P  A     V     R PG P  T  
Sbjct: 342 PGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSP--AATTACVPYAPSRPPGLPGTTTS 399

Query: 563 EFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSG-----DL 617
               +          P P    A    +  L V    RL P A S  +  L        L
Sbjct: 400 SSSSSSSNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHL 459

Query: 618 SSMPGPGTLSVRVSPPQPILSRGRP 642
           S  PGP   S    PP P L R  P
Sbjct: 460 SLPPGP---SSPPPPPCPRLLRPPP 481



 Score = 30.0 bits (66), Expect = 9.2
 Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 12/66 (18%)

Query: 570 PPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVR 629
           PP PAP PP    G ++  PS+P   P A     P P    R L G L S+ G     +R
Sbjct: 54  PPLPAPLPPSH--GSSSGHPSKPYYAPGA-----PTP----RPLHGKLESLHGCVQALLR 102

Query: 630 VSPPQP 635
             P QP
Sbjct: 103 -EPAQP 107


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
           sapiens]
          Length = 1362

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 117/481 (24%), Positives = 163/481 (33%), Gaps = 92/481 (19%)

Query: 189 KKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFS-------------SVVPVLLGDPEE 235
           +K+  K  R++++   K+++ + PPP++  K   S             S  P      EE
Sbjct: 545 EKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEE 604

Query: 236 EP-------GGRQL-LDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLT 287
           +          RQL LD+N    +    +  + QS    L+         N D I+ D  
Sbjct: 605 DKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKN-------SNPDEIEIDFE 657

Query: 288 PLQPSLDDFMD--ISDFFTNSRLPQPPMPS---------NFPEPPSFSPVVDSLFSSGTL 336
            L+PS    ++  ++      R PQ               F    S S    S   S   
Sbjct: 658 TLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDS 717

Query: 337 GPEVPPASSAMTHLSG------HSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPP 390
             E+ P S    H         H   Q     P P+               P P+ PPPP
Sbjct: 718 ETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQP----------PPPPQQPPPP 767

Query: 391 VPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPP----APGV 446
            PP     PPP   P   P    P    +PP  +  + P+  P+ P     P       +
Sbjct: 768 PPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPI 827

Query: 447 SPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKAS 506
             LP P   P  PQ  P    TP  +    +  S PA     ++P+ +P  PS R     
Sbjct: 828 LHLPQPELPPHLPQ--PPEHSTPPHLNQHAV-VSPPALHN--ALPQ-QPSRPSNRAAALP 881

Query: 507 PPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALE------PPLVSSTL------LRSP 554
           P    P   SP  T     P L Q   A  P+  LE      PPL S  +      L+  
Sbjct: 882 PKPARPPAVSPALT---QTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKV 938

Query: 555 GSPQETVPEFPCTFLPPTPAPTPPRP---------PPGPATLAPSRPLLVPKAERLSPPA 605
             P   +P       PP P P PP P         PP P    P +P   P+ +   PP 
Sbjct: 939 QPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPP---PPPQPQPPPQQQHQPPPR 995

Query: 606 P 606
           P
Sbjct: 996 P 996



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 95/377 (25%), Positives = 135/377 (35%), Gaps = 74/377 (19%)

Query: 264  PSPLQLPPEDAYVGNAD---MIQPDLTPLQPSLD-DFMDISDFFTNS--RLPQPPMPSNF 317
            P P  +P + A    +     I   +  L+P L     D    FT     LPQP +P + 
Sbjct: 780  PPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHL 839

Query: 318  PEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFL 377
            P+PP  S                PP      HL+ H+ + +  +    L       S+  
Sbjct: 840  PQPPEHS---------------TPP------HLNQHA-VVSPPALHNALPQQPSRPSNRA 877

Query: 378  LPEDPKPRLPPPPVP----PPLLHYPPPAKVPG-LEPCPPPPFPPMAPPTALLQEEPLFS 432
                PKP  PP   P     PLL  PP A+ P  L     PP PP+      L  + L  
Sbjct: 878  AALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQK 937

Query: 433  PRFPFPTVP-------PAPGVSPLPAPAAF---------PPTPQSVPSP----APTPFPI 472
             + P P +P       P P + P P P+           PP PQ  P P     P P P+
Sbjct: 938  VQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPV 997

Query: 473  ELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLL 532
             L P+ +S     P    P+G+ P   P GQ+  P    P  A P      ++       
Sbjct: 998  HLQPMQFSTHIQQP--PPPQGQQPPHPPPGQQPPP----PQPAKPQQVIQHHH------- 1044

Query: 533  TAAKPEQALEPPLVSSTLLRSPG-----SPQETVPEFPCTFLPPTPAPTPPRPPPGPATL 587
                P      P  +  L  +P      SPQ +  +      PP     P +     A++
Sbjct: 1045 ---SPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASV 1101

Query: 588  APSRPLLVPKAERLSPP 604
               +PL+V K E++  P
Sbjct: 1102 VQPQPLVVVKEEKIHSP 1118



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 66/253 (26%), Positives = 86/253 (33%), Gaps = 26/253 (10%)

Query: 397 HYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVP--PAPGVSPLPAPAA 454
           H+    + P   P  PPP P   PP    Q++    P  P P++P   AP +   P P  
Sbjct: 742 HHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFI 801

Query: 455 FPPTPQSVPSPAPTPFPIELLPLG-YSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPA 513
               P   P    + F     P+G +++P        P   P  P P      P     A
Sbjct: 802 ATQVPVLEPQLPGSVFD----PIGHFTQPILH--LPQPELPPHLPQPPEHSTPPHLNQHA 855

Query: 514 TASPPT--TAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPP 571
             SPP    A    P       AA P +   PP VS  L ++P  PQ  + + P   L  
Sbjct: 856 VVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLED 915

Query: 572 TPAPTPPRPP-------PGPATLAPSRPLL--VPKAERLSPPAPSGSERRLSGDLSSMPG 622
              P PP               + P  PLL  V    +  PP P      +   L   P 
Sbjct: 916 EEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPP 975

Query: 623 PGTLSVRVSPPQP 635
           P        PPQP
Sbjct: 976 P------PPPPQP 982



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 90/396 (22%), Positives = 132/396 (33%), Gaps = 93/396 (23%)

Query: 264  PSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPM-PSN----FP 318
            P P +LPP         + QP      P L+    +S    ++ LPQ P  PSN     P
Sbjct: 831  PQP-ELPPH--------LPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALP 881

Query: 319  EPPSFSPVVDSLFSSGTLGPEVP-------------PASSAMTHLSGHSRLQ-------- 357
              P+  P V    +   L P+ P             P +  +T +     LQ        
Sbjct: 882  PKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPP 941

Query: 358  --------ARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEP 409
                     ++  P PL      S    L + P P  PP P PPP   + PP +   L+P
Sbjct: 942  TPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQP 1001

Query: 410  C--------PPPP---FPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPT 458
                     PPPP    PP  PP    Q+ P      P     P   +    +P      
Sbjct: 1002 MQFSTHIQQPPPPQGQQPPHPPPG---QQPP------PPQPAKPQQVIQHHHSPRHHKSD 1052

Query: 459  PQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPP 518
            P S       P P+ +       P      S+    PP  + + +K     L  A+   P
Sbjct: 1053 PYSTGHLREAPSPLMI-----HSPQMSQFQSLTHQSPPQQNVQPKKQE---LRAASVVQP 1104

Query: 519  TTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSP--QETVPEFPCTFLPPTPAPT 576
                       Q L   K E+ +  P++ S     P SP  +   P+ P +   P   P 
Sbjct: 1105 -----------QPLVVVK-EEKIHSPIIRS----EPFSPSLRPEPPKHPESIKAPVHLPQ 1148

Query: 577  PPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERR 612
             P   P    +   RP++ P  +   PP     +++
Sbjct: 1149 RPEMKP----VDVGRPVIRPPEQNAPPPGAPDKDKQ 1180



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 48/173 (27%), Positives = 66/173 (38%), Gaps = 40/173 (23%)

Query: 399 PPPAKVPGLEPCPPP------PFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAP 452
           PP  + P  +P PPP      PFP + P   L+ + P+ +       VPP P  +P P P
Sbjct: 205 PPQTQTP--QPNPPPVQATPHPFPAVTPD--LIVQTPVMT------VVPPQPLQTPPPVP 254

Query: 453 AAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAP 512
                 PQ  P PAP P P++      S P       +     P  + +G K    T  P
Sbjct: 255 ------PQPQPPPAPAPQPVQ------SHPPI-----IAATPQPVKTKKGVKRKADTTTP 297

Query: 513 ATASPPTTAGS--NNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPE 563
            T  P     S    P  T+L    +  + ++PP         P S Q   PE
Sbjct: 298 TTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKD-----VPDSQQHPAPE 345



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 48/179 (26%), Positives = 69/179 (38%), Gaps = 31/179 (17%)

Query: 444 PGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQ 503
           PGVS +P       TP    +P P P P++  P  +  PA  P   +         P+  
Sbjct: 191 PGVSTVPNTTQ-ASTPPQTQTPQPNPPPVQATP--HPFPAVTPDLIVQTPVMTVVPPQPL 247

Query: 504 KASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPE 563
           + +PP + P    PP               A +P Q+  PP++++T    P   ++ V  
Sbjct: 248 Q-TPPPVPPQPQPPPA-------------PAPQPVQS-HPPIIAAT--PQPVKTKKGVKR 290

Query: 564 FPCTFLPPT--PAPTPPRPPPGPATL------APSRPLLVPK---AERLSPPAPSGSER 611
              T  P T  P   PP  PP P T         SRP+  PK    +    PAP  S +
Sbjct: 291 KADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSK 349



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 35/136 (25%), Positives = 48/136 (35%), Gaps = 33/136 (24%)

Query: 380 EDPKPRLPP--------PPVPP------PLLHYPPPAKVPGLEPCPPPPFPPMAPPTALL 425
           + P+P  PP        P V P      P++   PP  +    P PP P PP AP    +
Sbjct: 209 QTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPV 268

Query: 426 QEEPLFSPRFPFP------------TVPPAPGVSPLPAPAAFPPTPQSV------PSPAP 467
           Q  P      P P            T  P   + P+  P + PP P++        S  P
Sbjct: 269 QSHPPIIAATPQPVKTKKGVKRKADTTTPTT-IDPIHEPPSLPPEPKTTKLGQRRESSRP 327

Query: 468 TPFPIELLPLGYSEPA 483
              P + +P     PA
Sbjct: 328 VKPPKKDVPDSQQHPA 343



 Score = 36.6 bits (83), Expect = 0.099
 Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 15/92 (16%)

Query: 501 RGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQET 560
           RG+K +  T  P  ++ P T  ++ P  TQ      P+    PP V +T    P    + 
Sbjct: 181 RGRKETG-TAKPGVSTVPNTTQASTPPQTQT-----PQP--NPPPVQATPHPFPAVTPDL 232

Query: 561 VPEFPC-TFLPPTPAPTPP------RPPPGPA 585
           + + P  T +PP P  TPP      +PPP PA
Sbjct: 233 IVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPA 264



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 31/94 (32%), Positives = 36/94 (38%), Gaps = 21/94 (22%)

Query: 382 PKPRLPPPPVPPPL--LHYPPPAKVPGLEPCPP-----PPFPPMAPPTALLQEEPLFSPR 434
           P     P P PPP+    +P PA  P L    P     PP P   PP           P 
Sbjct: 205 PPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPP-----------PV 253

Query: 435 FPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPT 468
            P P  PPAP  +P P   + PP   + P P  T
Sbjct: 254 PPQPQPPPAP--APQPV-QSHPPIIAATPQPVKT 284



 Score = 33.9 bits (76), Expect = 0.64
 Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 12/80 (15%)

Query: 554 PGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRL 613
           PG  Q+         +   PAP P +PPP P    P  P   P+ ++  PP P       
Sbjct: 731 PGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPP---PQQQQQPPPPPPP----- 782

Query: 614 SGDLSSMPGPGTLSVRVSPP 633
                SMP     +++ SPP
Sbjct: 783 ----PSMPQQAAPAMKSSPP 798



 Score = 33.5 bits (75), Expect = 0.84
 Identities = 25/103 (24%), Positives = 38/103 (36%), Gaps = 8/103 (7%)

Query: 492 RGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLL 551
           RG+    + +   ++ P    A+  P T     NP   Q      P  A+ P L+  T +
Sbjct: 181 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQ--ATPHPFPAVTPDLIVQTPV 238

Query: 552 RSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLL 594
            +       VP  P    PP P    P P P P  +    P++
Sbjct: 239 MT------VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPII 275



 Score = 33.5 bits (75), Expect = 0.84
 Identities = 25/97 (25%), Positives = 34/97 (35%), Gaps = 12/97 (12%)

Query: 379 PEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFP 438
           P  P+P+ PP P P P+  +PP                  A  T     +P+  P    P
Sbjct: 252 PVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEP----P 307

Query: 439 TVPPAPGVSPL--------PAPAAFPPTPQSVPSPAP 467
           ++PP P  + L        P        P S   PAP
Sbjct: 308 SLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAP 344


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 109/403 (27%), Positives = 148/403 (36%), Gaps = 40/403 (9%)

Query: 265  SPLQLPPEDAYV----GNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEP 320
            SP   P   AY     G      P  +P  PS         +   S    P  PS  P  
Sbjct: 1590 SPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSP--SYSPTSPNYSPTSPSYSPTS 1647

Query: 321  PSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPE 380
            PS+SP   S   +    P   P S + +  S        +    P   S   +S    P 
Sbjct: 1648 PSYSPTSPSYSPTS---PSYSPTSPSYSPTS--PSYSPTSPSYSPTSPSYSPTSPSYSPT 1702

Query: 381  DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPP--PFPPMAPPTALLQEEPLFSPRFPFP 438
             P      P   P    Y P +  P   P  P   P  P   PT+     P +SP  P  
Sbjct: 1703 SPSYSPTSPSYSPTSPSYSPTS--PSYSPTSPSYSPTSPSYSPTS-----PNYSPTSPNY 1755

Query: 439  TVPPAPGVSPLPAPAAFPPTPQSVP-SPAPTPFPIELLPLGYSEPAFGPCFS--MPRGKP 495
            T P +P  SP  +P+  P +P   P SP  +P      P   S     P +S   PR  P
Sbjct: 1756 T-PTSPSYSPT-SPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTP 1813

Query: 496  PAPS--PRGQKASP--PTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLL 551
             +P+  P     SP  P+ +P +     T+ S +P   +  T   P+ +   P  S T  
Sbjct: 1814 QSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEY-TPTSPKYSPTSPKYSPTSP 1872

Query: 552  R-SPGSP--QETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSG 608
            + SP SP    T P++  T   PT +PT P   P     +P+ P   P + + SP +P+ 
Sbjct: 1873 KYSPTSPTYSPTTPKYSPT--SPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTY 1930

Query: 609  SERRLSGDLSSMPGPG--TLSVRVSPPQPILSRGRPDSNKTEN 649
            S     G   S   PG    S   S   P +S   PD +  EN
Sbjct: 1931 SPTSPKGSTYSPTSPGYSPTSPTYSLTSPAIS---PDDSDEEN 1970



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 93/390 (23%), Positives = 141/390 (36%), Gaps = 36/390 (9%)

Query: 262  SGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNF-PEP 320
            SG SP   P      G+     P  +P  PS    M  S +   S   +P  P  + P+ 
Sbjct: 1555 SGFSPGYSPAWSPTPGSPGSPGPS-SPYIPSPGGAMSPS-YSPTSPAYEPRSPGGYTPQS 1612

Query: 321  PSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPE 380
            PS+SP      +S +  P  P  S    + S  S   +      P   S   +S    P 
Sbjct: 1613 PSYSP------TSPSYSPTSPSYSPTSPNYSPTSPSYS------PTSPSYSPTSPSYSPT 1660

Query: 381  DPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPP--PFPPMAPPTALLQEEPLFSPRFPFP 438
             P      P   P    Y P +  P   P  P   P  P   PT+     P +SP  P  
Sbjct: 1661 SPSYSPTSPSYSPTSPSYSPTS--PSYSPTSPSYSPTSPSYSPTS-----PSYSPTSPSY 1713

Query: 439  TVPPAPGVSPLPAPAAFPPTPQSVP-SPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPA 497
            + P +P  SP  +P+  P +P   P SP+ +P      P   +     P +S P     +
Sbjct: 1714 S-PTSPSYSPT-SPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYS-PTSPSYS 1770

Query: 498  PSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSP 557
            P+      + P  +P + S   T+ S +P       ++       P    S+   SP SP
Sbjct: 1771 PTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSP 1830

Query: 558  QETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDL 617
              +      T   P+ +P+ P   P     +P+ P   P + + SP +P+ S        
Sbjct: 1831 SYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYS-------- 1882

Query: 618  SSMPGPGTLSVRVSPPQPILSRGRPDSNKT 647
             + P     S   SP  P+ +   P  + T
Sbjct: 1883 PTTPKYSPTSPTYSPTSPVYTPTSPKYSPT 1912



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 63/229 (27%), Positives = 89/229 (38%), Gaps = 20/229 (8%)

Query: 431  FSPRFPFPTVPPAPGVSPLPA----------PAAFPPTPQSVPSPAPTPFPIELLPLGYS 480
            +SP       P A G SP  A            A+ PTP S  SP P+  P    P G  
Sbjct: 1531 WSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSS-PYIPSPGGAM 1589

Query: 481  EPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQA 540
             P++ P  + P  +P   SP G     P+ +P + S   T+ S +P        +     
Sbjct: 1590 SPSYSP--TSPAYEP--RSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSP 1645

Query: 541  LEPPLVSSTLLRSPGSP--QETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKA 598
              P    ++   SP SP    T P +  T   P+ +PT P   P   + +P+ P   P +
Sbjct: 1646 TSPSYSPTSPSYSPTSPSYSPTSPSYSPT--SPSYSPTSPSYSPTSPSYSPTSPSYSPTS 1703

Query: 599  ERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKT 647
               SP +PS S    S   +S P     S   SP  P  S   P+ + T
Sbjct: 1704 PSYSPTSPSYSPTSPSYSPTS-PSYSPTSPSYSPTSPSYSPTSPNYSPT 1751


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,907,255
Number of Sequences: 37866
Number of extensions: 3519359
Number of successful extensions: 72334
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 660
Number of HSP's successfully gapped in prelim test: 2116
Number of HSP's that attempted gapping in prelim test: 21723
Number of HSP's gapped (non-prelim): 20970
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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