Search of human proteins with 145699133

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
         (1822 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145699133 KPL2 protein isoform 1 [Homo sapiens]                   3610   0.0  
gi|21389509 KPL2 protein isoform 2 [Homo sapiens]                     996   0.0  
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    62   7e-09
gi|148746195 trichohyalin [Homo sapiens]                               59   4e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    59   6e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    59   6e-08
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ...    56   4e-07
gi|147903302 MAP7 domain containing 3 [Homo sapiens]                   56   4e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    56   4e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     55   5e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    55   5e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    54   1e-06
gi|94721321 coiled-coil domain containing 11 [Homo sapiens]            54   1e-06
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    53   3e-06
gi|92859701 myosin VI [Homo sapiens]                                   52   4e-06
gi|109134347 NY-REN-58 antigen [Homo sapiens]                          52   5e-06
gi|109134355 NY-REN-58 antigen [Homo sapiens]                          52   5e-06
gi|148612801 KIAA1009 protein [Homo sapiens]                           52   5e-06
gi|42794779 myosin 18A isoform b [Homo sapiens]                        51   9e-06
gi|28416946 myosin 18A isoform a [Homo sapiens]                        51   9e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    51   1e-05
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    51   1e-05
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    51   1e-05
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    51   1e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    51   1e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    51   1e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    51   1e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    51   1e-05
gi|21735548 centrosomal protein 2 [Homo sapiens]                       50   3e-05
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    49   3e-05

>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
          Length = 1822

 Score = 3610 bits (9360), Expect = 0.0
 Identities = 1822/1822 (100%), Positives = 1822/1822 (100%)

Query: 1    MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL 60
            MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL
Sbjct: 1    MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL 60

Query: 61   NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM 120
            NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM
Sbjct: 61   NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM 120

Query: 121  QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER 180
            QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER
Sbjct: 121  QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER 180

Query: 181  FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE 240
            FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE
Sbjct: 181  FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE 240

Query: 241  AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED 300
            AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED
Sbjct: 241  AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED 300

Query: 301  AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE 360
            AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE
Sbjct: 301  AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE 360

Query: 361  VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA 420
            VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA
Sbjct: 361  VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA 420

Query: 421  RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT 480
            RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT
Sbjct: 421  RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT 480

Query: 481  LPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA 540
            LPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA
Sbjct: 481  LPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA 540

Query: 541  EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQA 600
            EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQA
Sbjct: 541  EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQA 600

Query: 601  FHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSA 660
            FHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSA
Sbjct: 601  FHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSA 660

Query: 661  NADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQ 720
            NADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQ
Sbjct: 661  NADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQ 720

Query: 721  DCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDF 780
            DCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDF
Sbjct: 721  DCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDF 780

Query: 781  VILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGF 840
            VILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGF
Sbjct: 781  VILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGF 840

Query: 841  LDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEK 900
            LDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEK
Sbjct: 841  LDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEK 900

Query: 901  KAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGK 960
            KAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGK
Sbjct: 901  KAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGK 960

Query: 961  GKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVP 1020
            GKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVP
Sbjct: 961  GKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVP 1020

Query: 1021 EEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDF 1080
            EEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDF
Sbjct: 1021 EEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDF 1080

Query: 1081 VAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWL 1140
            VAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWL
Sbjct: 1081 VAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWL 1140

Query: 1141 QDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKD 1200
            QDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKD
Sbjct: 1141 QDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKD 1200

Query: 1201 NSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQA 1260
            NSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQA
Sbjct: 1201 NSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQA 1260

Query: 1261 SLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSP 1320
            SLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSP
Sbjct: 1261 SLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSP 1320

Query: 1321 PMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLED 1380
            PMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLED
Sbjct: 1321 PMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLED 1380

Query: 1381 LVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGN 1440
            LVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGN
Sbjct: 1381 LVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGN 1440

Query: 1441 IKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTL 1500
            IKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTL
Sbjct: 1441 IKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTL 1500

Query: 1501 NLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQK 1560
            NLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQK
Sbjct: 1501 NLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQK 1560

Query: 1561 FKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYE 1620
            FKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYE
Sbjct: 1561 FKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYE 1620

Query: 1621 KDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAE 1680
            KDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAE
Sbjct: 1621 KDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAE 1680

Query: 1681 EFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRF 1740
            EFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRF
Sbjct: 1681 EFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRF 1740

Query: 1741 ASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQ 1800
            ASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQ
Sbjct: 1741 ASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQ 1800

Query: 1801 RSEHVQGSDGERSPSRHTEEKK 1822
            RSEHVQGSDGERSPSRHTEEKK
Sbjct: 1801 RSEHVQGSDGERSPSRHTEEKK 1822


>gi|21389509 KPL2 protein isoform 2 [Homo sapiens]
          Length = 514

 Score =  996 bits (2576), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL 60
           MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL
Sbjct: 1   MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKL 60

Query: 61  NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM 120
           NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM
Sbjct: 61  NNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTM 120

Query: 121 QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER 180
           QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER
Sbjct: 121 QRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLER 180

Query: 181 FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE 240
           FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE
Sbjct: 181 FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE 240

Query: 241 AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED 300
           AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED
Sbjct: 241 AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEED 300

Query: 301 AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE 360
           AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE
Sbjct: 301 AFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE 360

Query: 361 VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA 420
           VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA
Sbjct: 361 VLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQA 420

Query: 421 RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT 480
           RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT
Sbjct: 421 RYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKT 480

Query: 481 LPANPSREQLTELEKRDLLDTNDYEEYK 508
           LPANPSREQLTELEKRDLLDTNDYEEYK
Sbjct: 481 LPANPSREQLTELEKRDLLDTNDYEEYK 508


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 63/308 (20%), Positives = 145/308 (47%), Gaps = 30/308 (9%)

Query: 121 QRLTNLRLQNMKSDTFQERL---RHMIPRQ------TDFNLMRITYRFQEKYKHVKEDLA 171
           Q L+ +  Q  K+D + E L   R  +  +      TD  L     + QEK + V+ + +
Sbjct: 167 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 226

Query: 172 HLHFE------KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
            +         KLER + L  +Q+    E  +L +  Q+ + AK+QA   Q+ +      
Sbjct: 227 EIQLNVKELKRKLERAKLLLPQQQ-LQAEADHLGKELQS-VSAKLQA---QVEENELWNR 281

Query: 226 LKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYS 285
           L   + +KM +++++ ++  ++I++ E  I++  +      +   +   +        + 
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 341

Query: 286 DDEYIKKIQKRLEEDAFAREQREKRRRK-LLMDQLIAHEAQEEAYREEQLINRLMRQSQQ 344
            +E I+++++++ E    REQ EKR+ +  + +Q    E + + +R+E+ I    R+ ++
Sbjct: 342 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI----REQEE 397

Query: 345 ERRIAVQLMHVRHEK-----EVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDF 399
           + R   ++M  + EK     E +W+     ++Q E+ R ++ +     +    ++ KI  
Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457

Query: 400 EEQFLKEK 407
           +E+ ++E+
Sbjct: 458 QEEMMQEQ 465



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 69/386 (17%), Positives = 171/386 (44%), Gaps = 43/386 (11%)

Query: 49  EFLDSRVSSAKLNNFS---RLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQ-----L 100
           + ++S  S  +LN      +LE    LL  Q  Q  A  +  E   V+ KL  Q     L
Sbjct: 219 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 278

Query: 101 YIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQ 160
           +  L ++++  +   E +  +R   ++ Q  K    +E++R       +        R Q
Sbjct: 279 WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE---KEEKMRRQ 335

Query: 161 EKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKP 220
           E+    KE+      EK+   +K++E++     ++Q   + R+ E   + +A + +  + 
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQEEK 391

Query: 221 ASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDL 280
              +  K  E ++MM++++E     +E K +E   ++++Q +E   +             
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEE-KMWEQ--EEEMQEQEEKMRRQ----------- 437

Query: 281 LNTYSDDEYIKKIQKRL-EEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLM 339
                 +E I++ +K++ E++   REQ E  + +   ++ +  +  +   +E ++  +  
Sbjct: 438 ------EEKIREQEKKIREQEEKIREQEEMMQEQ---EEKMGEQEGKMCEQEAKMQEQEE 488

Query: 340 RQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDF 399
           +  +QE +I  Q   +R ++E + +     ++Q E+   ++ +     E    ++ K+  
Sbjct: 489 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 548

Query: 400 EEQFLKEKRFHDQIAVERAQARYEKH 425
           +E+ ++E+    ++ + + + + ++H
Sbjct: 549 QEEKMREQ----EVRLRQQEEKMQEH 570


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 59/294 (20%), Positives = 131/294 (44%), Gaps = 17/294 (5%)

Query: 137 QERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQ 196
           QERL     ++ D  L R    +QE+ +   E+         E+ Q  K  +     +++
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQEREERRAEE---------EQLQSCKGHETEEFPDEE 208

Query: 197 YLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKK----KKEAEDVADEIKKFE 252
            L RR   E+  K +    Q  +   +R  +  E ++  K+    +KE E + +E  + +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 253 ALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQK--RLEEDAFAREQREKR 310
             ++++ +      +  L    Q           ++ +++ Q+  R E+    REQ+E+R
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328

Query: 311 RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFRE 370
            ++    +      QEE  R EQ + R   + ++E+++  +    R E+++  + ++ RE
Sbjct: 329 EQQEERREQQLRREQEE--RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386

Query: 371 KQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
           +Q    +    +  L RE  L ++ ++  E+Q  +E++   +   ER + ++E+
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 68/325 (20%), Positives = 143/325 (44%), Gaps = 47/325 (14%)

Query: 105  QKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYK 164
            Q ++KS      +     L   R + ++++  Q+R +  +P + +    R   R +EK  
Sbjct: 772  QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831

Query: 165  HVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNR 224
               E+   L  ++ ER Q+L+EE+    +++    RR Q +   +     ++  +     
Sbjct: 832  QFLEEEEQL--QRRERAQQLQEEED--GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887

Query: 225  TLKALEA-QKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNT 283
            TL A  A Q+ ++K+++     +E  + E   K+  Q +E                    
Sbjct: 888  TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER------------------- 928

Query: 284  YSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLI----NRLM 339
                +Y ++ Q + EE+   RE+REKRRR          + +E  YR+++ +     +L+
Sbjct: 929  ----QYREEEQLQQEEEQLLREEREKRRR----------QERERQYRKDKKLQQKEEQLL 974

Query: 340  RQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDF 399
             +  ++RR   +    R E+E+  +      ++ E+RR ++++    ++  L ++     
Sbjct: 975  GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE----- 1029

Query: 400  EEQFLKEKRFHDQIAVERAQARYEK 424
            EEQ L+E+R   ++     Q R E+
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEE 1054



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 76/362 (20%), Positives = 151/362 (41%), Gaps = 53/362 (14%)

Query: 157  YRFQEKYKHVKEDLAHLHFEKL---ERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAA 213
            YR  +K +  +E L     EK    ER +K +EE+     E+Q L   R+     + +  
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE-- 1017

Query: 214  IIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTA 273
                 +    +     E ++++++++E   + +  +++    +++LQ +E          
Sbjct: 1018 -----RQYRKKDELQQEEEQLLREEREKRRLQERERQYRE--EEELQQEEE------QLL 1064

Query: 274  GQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ 333
            G+          + +Y K+ + + EE+   RE+ EKRRR+    Q      +EE  +EE+
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC---REEEELQQEEE 1121

Query: 334  LINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAK 393
               +L+R+ +++RR        R E+EV  +      ++ E+RR ++ +     E  L +
Sbjct: 1122 ---QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178

Query: 394  QAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNL 453
            +     EEQ L+E++       E+ +   E+ Y    E+  Q      +  D R      
Sbjct: 1179 E-----EEQLLREEQ-------EKRRQERERQYREEEELQRQKRKQRYRDEDQR------ 1220

Query: 454  IPYKLMHDWKELFFNAKPIYEQA--SVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMV 511
                      +L +  +P  E A    K        EQ  +LE   L D    ++ ++++
Sbjct: 1221 ---------SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271

Query: 512  GE 513
            GE
Sbjct: 1272 GE 1273



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 57/286 (19%), Positives = 128/286 (44%), Gaps = 14/286 (4%)

Query: 139 RLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYL 198
           R R  + R+ +  L     + Q + +  +E L  L  ++L R ++ +EEQ+   + ++  
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR-ERQEEEQQQQRLRREQQ 305

Query: 199 NRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKD 258
            RR+Q E   + Q    +  +    R  +  E ++   ++++ E    ++++ +   +++
Sbjct: 306 LRRKQEEERREQQ----EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361

Query: 259 LQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQ 318
            Q +    +   +   +    L      ++ +++ Q+   E    REQ+ +R ++L  +Q
Sbjct: 362 QQLRREQEEERREQQLRREQQLRR----EQQLRREQQLRREQQLRREQQLRREQQLRREQ 417

Query: 319 LIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRL 378
            +  E Q    R EQ   R  ++ +QERR   Q +    E+   W  R    ++HE+ R 
Sbjct: 418 QLRREQQ---LRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREEETERHEQERR 472

Query: 379 KDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
           K        E    +  K++ EE+  +++R   Q+  E+ + R ++
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 68/299 (22%), Positives = 129/299 (43%), Gaps = 39/299 (13%)

Query: 127 RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKE 186
           R Q +K +  QE  R  + R+ +        R Q+  +  +E       E+ ER+ KL+E
Sbjct: 443 REQRLKRE--QEERRDWLKREEETERHEQERRKQQLKRDQEE-------ERRERWLKLEE 493

Query: 187 EQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVAD 246
           E+R    E++    RR+ E                          ++ +K+++E E +  
Sbjct: 494 EERREQQERREQQLRREQEE-----------------------RREQRLKRQEEEERLQQ 530

Query: 247 EIKKFEALIKKDLQAKESASKTSLDTA-GQTTTDLLNTYSDDEYIKKIQKRLEEDAFARE 305
            ++  + L ++  + +E   K   +    Q   +       +E   ++ KR EE    R+
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE---RRQ 587

Query: 306 QREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQN 365
           QR KR ++  ++Q +  E  E   +EE+   RL R+  +E R   QL+    ++E   Q 
Sbjct: 588 QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER-RQQLLKSEEQEERRQQQ 646

Query: 366 RIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
               +++  E+RLK  ++    E  L ++ + +  EQ L E+    + A ER ++R  K
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE--EQEQARERIKSRIPK 703



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 72/318 (22%), Positives = 140/318 (44%), Gaps = 31/318 (9%)

Query: 118 QTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEK 177
           Q ++R   LR +       Q R    + R+      +   R Q+  +  +E+      E+
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440

Query: 178 LERFQKLKEEQRCFDIEKQYLNRRRQ---NEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
             R Q+LK EQ   +  + +L R  +   +E   + Q       +    R LK  E ++ 
Sbjct: 441 ERREQRLKREQ---EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497

Query: 235 MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSD--DEYIKK 292
            ++++  + +  E ++     +++ + K    +  L    ++   L     +  ++ +K+
Sbjct: 498 EQQERREQQLRREQEE-----RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 293 IQ-KRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQ 351
            + KRLE++   REQR KR ++   DQL+  E       EE+   RL R+  QE R+  +
Sbjct: 553 EEEKRLEQER--REQRLKREQEERRDQLLKRE-------EERRQQRLKRE--QEERLEQR 601

Query: 352 LMH---VRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKR 408
           L      R E+E   + R+ RE+  EERR +  +     E    +Q ++  E+Q  +E+R
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE---RRQQQLRREQQERREQR 658

Query: 409 FHDQIAVERAQARYEKHY 426
              +   ER + R ++ +
Sbjct: 659 LKREEEEERLEQRLKREH 676



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 60/301 (19%), Positives = 145/301 (48%), Gaps = 28/301 (9%)

Query: 114  GVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHL 173
            G E +  ++L + +L++ +S   Q+ L+H++  Q + +  +   R+Q++ +H  E+    
Sbjct: 1244 GRENEQFRQLEDSQLRDRQS---QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300

Query: 174  HFEKLE---RFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALE 230
              E+ E   R +K +EE++    E++   RR++ +   + +  ++Q       R  + L 
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ------EREEQPLR 1354

Query: 231  AQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYI 290
             Q+  +K +E E       + +   +K L+ ++   +   +         L     ++ +
Sbjct: 1355 RQERDRKFREEE------LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL 1408

Query: 291  KKIQKRL---EEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            ++ + R    EE   +R++R+++ R+   +Q +  + +E  + EE+   +L ++  ++ R
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFRE--EEQQVRRQERERKFLEEE--QQLRQERHRKFR 1464

Query: 348  IAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
               QL+  R E+++  Q R  +  + E++  +  +D   RE  L  Q   + E +FL+E+
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ---EPERKFLEEE 1521

Query: 408  R 408
            +
Sbjct: 1522 Q 1522



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 70/362 (19%), Positives = 149/362 (41%), Gaps = 39/362 (10%)

Query: 160  QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
            +EK +  + +L     E+  R Q+ +E++R F  + Q   +  +       +  +    +
Sbjct: 736  EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL----R 791

Query: 220  PASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTD 279
                R L+A E Q+  ++    E+  ++ ++     +K+LQ  E   +       Q   +
Sbjct: 792  EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 280  LLNTYSDDEYIKKIQKRLEEDAFA---REQREKRRRKLLMDQLIAHEAQEEAYREEQLI- 335
              +   +D+  ++ Q++  +  +     E+R++RR  L     +    QE+  +E+QL+ 
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL----QEQLRKEQQLLQ 907

Query: 336  ---NRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALA 392
                 L R+ +++RR   Q    R E+++  +      ++ E+RR +      +RE    
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ------ERERQYR 961

Query: 393  KQAKI-DFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTN 451
            K  K+   EEQ L E+        +R +   EK Y    E+  +   L  +  + R    
Sbjct: 962  KDKKLQQKEEQLLGEE------PEKRRRQEREKKYREEEELQQEEEQLLREEREKRR--- 1012

Query: 452  NLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMV 511
                     +W E  +  K   +Q   + L     + +L E E++   +    +E + ++
Sbjct: 1013 -------RQEW-ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064

Query: 512  GE 513
            GE
Sbjct: 1065 GE 1066



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 59/293 (20%), Positives = 124/293 (42%), Gaps = 51/293 (17%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E + ++    LR Q  +    Q+R R     +   +      +F+E+ + V+       F
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448

Query: 176  EKLERFQKLKEEQ-RCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
              LE  Q+L++E+ R F  E+Q L  R + ++  +              R  K LE ++ 
Sbjct: 1449 --LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ-------------ERDRKFLEEEQQ 1493

Query: 235  MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQ 294
            +++++      ++  + +   +K L+ ++   +                       ++ +
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ----------------------QRQR 1531

Query: 295  KRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMH 354
            K L+E+   R Q   ++R+   D+    E Q    REEQ ++R     +++R+  ++   
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR----QERDRKFRLEEQK 1587

Query: 355  VRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
            VR ++    Q R F E + + RR ++ Q  L +E    +  K   +EQ L+E+
Sbjct: 1588 VRRQE----QERKFMEDEQQLRR-QEGQQQLRQE----RDRKFREDEQLLQER 1631



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 66/314 (21%), Positives = 139/314 (44%), Gaps = 29/314 (9%)

Query: 137  QERLRHMIPRQT---DFNLMRITYRFQEKYKHVKEDLAHLHFE------KLERFQKLKEE 187
            QER    + RQ     F L     R QE+ +   ED   L  +      + ER +K +E+
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624

Query: 188  QRCF-DIEKQYLNRRRQNEIMAKIQAAIIQIPKPAS---NRTLKALEAQKMMKKKKEAED 243
            ++   + E+Q L+R+ ++    + +  + +  +      +R  K  E ++++++ +E + 
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684

Query: 244  VADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIK------------ 291
               E  +     ++ L+ +E   K   +       +L   + ++E ++            
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744

Query: 292  KIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQ 351
            + +K LEE+    E+ E++ R+   D+    E Q    REEQ +    ++S ++ R   Q
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR--SQESDRKFREEEQ 1802

Query: 352  LMHVRHEKEVLWQNRIFREKQHEER-RLKDFQDALDREAALAKQAKIDFEEQFLKEKRFH 410
            L   R E+++  Q R  + +  EE+ +L++ +  L +E     +A+  F  Q  K +R  
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ-EKSRREE 1861

Query: 411  DQIAVERAQARYEK 424
             ++  E  Q R ++
Sbjct: 1862 QELWQEEEQKRRQE 1875



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 36/155 (23%), Positives = 68/155 (43%), Gaps = 23/155 (14%)

Query: 291  KKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINR------------- 337
            ++ +K  EE    RE+RE++RR+   D+    E Q    REEQ + R             
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368

Query: 338  -------LMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAA 390
                    + + Q+ RR   +   ++ E+++  Q R  + +Q  +R+ ++ +  L R+  
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE- 1427

Query: 391  LAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKH 425
              +  K   EEQ ++ +    +   E  Q R E+H
Sbjct: 1428 --RDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 69/315 (21%), Positives = 132/315 (41%), Gaps = 41/315 (13%)

Query: 127 RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLE-RFQKLK 185
           R Q +KS+  +ER +  + R+          R +++ K  +E+      E+LE R ++  
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQ-------ERREQRLKREEEE------ERLEQRLKREH 676

Query: 186 EEQRCFDIEKQYLNRRRQNEIMAKIQAAII----QIPKPASNRTLKALEAQKMMKKKKEA 241
           EE+R     +Q L    Q +   +I++ I     Q+   A  R  K     +  + ++  
Sbjct: 677 EEER----REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732

Query: 242 EDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDA 301
           ++  ++ ++ E+    +LQ +E           +   D    +  +E  ++ ++RL    
Sbjct: 733 QEQEEKRRRRES----ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788

Query: 302 FAREQREKRRR---KLLMDQLIAHEAQEEAYREEQLINR------LMRQSQQERRIAVQL 352
             REQRE++ R   +   +Q    E +E+  R  Q   R      L  + Q +RR   Q 
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848

Query: 353 MHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQ---AKIDFEEQFLKEKRF 409
           +    E+E   Q    R +  E+RR + ++  L+ E    +    AK   +EQ  KE++ 
Sbjct: 849 L---QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905

Query: 410 HDQIAVERAQARYEK 424
             +   E  +   EK
Sbjct: 906 LQEEEEELQREEREK 920



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 54/224 (24%), Positives = 109/224 (48%), Gaps = 27/224 (12%)

Query: 158  RFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQI 217
            R QE+ +  +E+   L  ++ ER + L+EEQ+   + +Q L R+ + E   + +    Q+
Sbjct: 1685 RRQERDRKFREEEQQLRRQERER-KFLQEEQQ---LRRQELERKFREEEQLRQETEQEQL 1740

Query: 218  PKPASNRTLKALEAQKMMKKKKEAEDVADEI-KKFEALIKKDLQAKESASKTSLDTAGQT 276
             +    R  K LE +++  +++E +    E  +KF    +++ Q ++   +  L +    
Sbjct: 1741 RR--QERYRKILEEEQLRPEREEQQLRRQERDRKF----REEEQLRQEREEQQLRSQESD 1794

Query: 277  TTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                   + ++E ++  Q+R EE     +QR+ + R    ++ +  E QE+  R+E+   
Sbjct: 1795 -----RKFREEEQLR--QER-EEQQLRPQQRDGKYR--WEEEQLQLEEQEQRLRQER--- 1841

Query: 337  RLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKD 380
               RQ + E + A Q    R E+E LWQ    + +Q  ER+L++
Sbjct: 1842 --DRQYRAEEQFATQEKSRREEQE-LWQEEEQKRRQERERKLRE 1882



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 66/355 (18%), Positives = 146/355 (41%), Gaps = 66/355 (18%)

Query: 106  KKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKH 165
            ++++  L G E +T +R   L  Q  K +  Q+    ++  + +        R QE+ + 
Sbjct: 1057 QQEEEQLLGEERETRRR-QELERQYRKEEELQQEEEQLLREEPEKR------RRQERERQ 1109

Query: 166  VKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
             +E+   L  E+ +  ++ +E++R  ++E+QY   R + E+  + +  + + P+    + 
Sbjct: 1110 CREE-EELQQEEEQLLREEREKRRRQELERQY---REEEEVQQEEEQLLREEPEKRRRQE 1165

Query: 226  LKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSL-----------DTAG 274
            L+    ++   +++E + + +E +K     ++  + +E   +              D   
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225

Query: 275  QTTTDLLNTYSDDEYIKK-----------------------IQKRLEEDAFAREQREKRR 311
            Q   +  N   D++   K                       +Q  L E      ++E+RR
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285

Query: 312  -----RKLLMDQLIAHEAQEEA-------------YREEQLINRLMRQSQQERRIAVQLM 353
                 R    ++ +  E Q+EA              REE+   R  +++ ++ R   QL+
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL 1345

Query: 354  HVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKR 408
              R E+ +  Q R  + ++ E R  +  +  L+ E  L +Q +   E +FLKE++
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER---ERKFLKEEQ 1397



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 61/319 (19%), Positives = 126/319 (39%), Gaps = 53/319 (16%)

Query: 1068 QEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEA 1127
            ++ L+R + +Q    +    F    D+    E  + +LH++  D R  L +    R++E 
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFRE--DEQLLQEREEQQLHRQERD-RKFLEEEPQLRRQER 1657

Query: 1128 EQ-----------ERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYW-- 1174
            EQ           E   ++ E   Q       +  F   + +L R +  ++ LQ+     
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717

Query: 1175 --GMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLK 1232
               +E K   E+  R           ++  + QLR     R  +  E + P+ + + + +
Sbjct: 1718 RQELERKFREEEQLR-----------QETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766

Query: 1233 GKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKS 1292
             + D         F  +E+L  +  +Q       + + E  ++  EEE+  Q  + ++  
Sbjct: 1767 QERDRK-------FREEEQLRQEREEQ------QLRSQESDRKFREEEQLRQEREEQQLR 1813

Query: 1293 PQMGANK-KVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIA----------EIKRK 1341
            PQ    K + ++E  + ++++++ + +      A     T E+            E KR+
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873

Query: 1342 NELRVKIKEEHLAALQFEE 1360
             E   K++EEH+   Q EE
Sbjct: 1874 QERERKLREEHIRRQQKEE 1892


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 74/354 (20%), Positives = 163/354 (46%), Gaps = 49/354 (13%)

Query: 121 QRLTNLRLQNMKSDTFQERL---RHMIPRQ------TDFNLMRITYRFQEKYKHVKEDLA 171
           Q L+ +  Q  K+D + E L   R  +  +      TD  L     + QEK + V+ + +
Sbjct: 179 QALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKS 238

Query: 172 HLHFE------KLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
            +         KLER + L  +Q+    E  +L +  Q+ + AK+QA   Q+ +      
Sbjct: 239 EIQLNVKELKRKLERAKLLLPQQQ-LQAEADHLGKELQS-VSAKLQA---QVEENELWNR 293

Query: 226 LKALEAQKMMKKKKEAEDVADEIKKFEALIKK-DLQAKESASKTSLDTAGQTTTDLLNTY 284
           L   + +KM +++++ ++  ++I++ E  I++ + + +E   K           +     
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 285 SDDEYIKKIQK--RLEEDAFAREQREKRRRKLLM--------------DQLIAHEAQEEA 328
            ++   +K +K  R EE  + +E++ +R+ +++               +Q    E +E+ 
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413

Query: 329 YREEQLINRLMRQSQ------QERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQ 382
             EE++  +  RQ Q      QE +I  Q   +R +++ +W+     EK HE+ ++++ +
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ---EEKIHEQEKIREEE 470

Query: 383 DALDREAALAKQAKIDFEEQFLKEK-RFHDQIAVERAQARYEKHYSVCAEILDQ 435
              ++E    ++ KI  +E+  ++K + H+Q   E+ + + EK +    +I +Q
Sbjct: 471 KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ--EEKIRKQEEKVWRQEEKIREQ 522



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 55/288 (19%), Positives = 134/288 (46%), Gaps = 22/288 (7%)

Query: 158 RFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQI 217
           R QE+    KE+      EK+   +K++E++     ++Q   + R+ E   + +A + + 
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEKIREQEKRQEQEAKMWRQ 435

Query: 218 PKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTT 277
            +    +  K  E +K M +++E     ++I++ E   K+  Q +    +  +    +  
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE---KRQEQEEMWRQEEKIHEQEEIW 492

Query: 278 TDLLNTYSDDEYIKKIQKRL--------EEDAFAREQREK--RRRKLLMDQLIAHEAQEE 327
                 +  +E I+K ++++        E++   REQ EK  R+ + + +Q      +E+
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552

Query: 328 AYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDR 387
            + +E++     RQ +QE ++  Q   +R ++E +W+      +Q E+R+ ++ +     
Sbjct: 553 MHEQEKIWEEEKRQ-EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQE 611

Query: 388 EAALAKQAKIDFEEQFLKEK----RFHDQIAVERAQARYEKHYSVCAE 431
           E    ++ KI  +E+ ++E+    R  +++  E+ +   E+   +C +
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 659



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 44/228 (19%), Positives = 110/228 (48%), Gaps = 17/228 (7%)

Query: 158 RFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNR----RRQNEIMAKIQAA 213
           R QE+    +E+      E     +K+ E+++ ++ EK+        R++ +I  + +  
Sbjct: 527 REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586

Query: 214 IIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKD---LQAKESASKTSL 270
             Q  K       +  + +KM K++++  +  ++I++ E  I++    ++ +E  ++   
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQE 646

Query: 271 DTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYR 330
           +  G+    +       E  +K+Q++ EE  + +E++ + + K + +Q      QEE  +
Sbjct: 647 EKMGEQEEKMC------EQEEKMQEQ-EETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699

Query: 331 E--EQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEER 376
           E  E++  +  +  +QE ++  Q   +R ++E +W+  + R +Q EE+
Sbjct: 700 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV-RLRQQEEK 746



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 59/326 (18%), Positives = 153/326 (46%), Gaps = 20/326 (6%)

Query: 118 QTMQRLTNLRLQNMKSDTFQERLRHMIPRQT-DFNLMRITYRFQEKYKHVKEDLAHL--H 174
           + M     +R Q  K    +E++R    RQ  +  + R   + +E+ + ++E    +   
Sbjct: 398 EKMHEQEKIREQEEKRQE-EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 456

Query: 175 FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
            EK+   +K++EE++  + E+ +    RQ E + + +    Q  K          + +K+
Sbjct: 457 EEKIHEQEKIREEEKRQEQEEMW----RQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512

Query: 235 MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQ 294
            +++++  +  ++I++ E  + +  Q ++   +  +    +   +    + +++  ++  
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWR--QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570

Query: 295 KRLEEDAFAREQREK--RRRKLLMDQLIAHEAQEEAY--REEQLINRLMRQSQQERRIAV 350
           K   ++   REQ EK  R+ + + +Q    + QEE    +EE++  +  +  +QE +I  
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630

Query: 351 QLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQA-KIDFEEQFLKEK-- 407
           Q   +R E+E + Q +  +  + EE+  +  +   ++E  + +Q  KI  +E+ ++E+  
Sbjct: 631 QEEKIR-EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE 689

Query: 408 --RFHDQIAVERAQARYEKHYSVCAE 431
             R  +++  E+ +  +E+   +C +
Sbjct: 690 KIREQEEMMQEQEEKMWEQEEKMCEQ 715



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 57/299 (19%), Positives = 138/299 (46%), Gaps = 21/299 (7%)

Query: 137 QERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKL-KEEQRCF---- 191
           QE++R    RQ    + R     QE+  H +E++     +  E+ +K+ K+E++ +    
Sbjct: 463 QEKIREEEKRQEQEEMWR-----QEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517

Query: 192 DIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKF 251
            I +Q    R Q E M + Q   I+  +       K  E +K+ +++K  E   D++ + 
Sbjct: 518 KIREQEEKIREQEEKMWR-QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ-EDKMWRQ 575

Query: 252 EALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEE-DAFAREQREKR 310
           E  I++  +      +   +   +        +  +E I++ +++++E +   REQ EK 
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635

Query: 311 RRKLLMDQ----LIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNR 366
           R +  M Q     +  + ++   +EE++  +     +QE +I  Q   +R ++E + +  
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695

Query: 367 IFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKH 425
              ++Q EE+  +  +   ++E  + +Q +   + +  +EK +  ++ + + + + ++H
Sbjct: 696 EMMQEQ-EEKMWEQEEKMCEQEEKMQEQEE---KMRRQEEKMWEQEVRLRQQEEKMQEH 750



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 53/308 (17%), Positives = 124/308 (40%), Gaps = 40/308 (12%)

Query: 1068 QEFLKRPDHKQDFVAQW-QADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEE 1126
            QE ++  + +Q+    W Q +     +++W  +E   E  +++    +++W     R+EE
Sbjct: 463  QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW-----RQEE 517

Query: 1127 AEQERLDIINES----WLQDTLGMTMNHFF---SLMQAELNRFQDTKRLLQ-DYYWGMES 1178
              +E+ + I E     W Q+         +     M  +   +++ KR  Q D  W  E 
Sbjct: 518  KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577

Query: 1179 KIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNS 1238
            KI  ++ K + +   ++   +   E + ++                 K +  ++ + +  
Sbjct: 578  KIREQEEKVWRQEEKIREQEEKRQEQEEKM----------------WKQEEKIREQEEKI 621

Query: 1239 LENVESNFEADEKL----VMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQ 1294
             E  E   E +EK+     M   Q+  +        E  +++ E+E+     + K +  +
Sbjct: 622  QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE 681

Query: 1295 MGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELR--VKIKEEH 1352
                KK++++  K +++++  + +   M E    +   EE  + + +   R   K+ E+ 
Sbjct: 682  ----KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737

Query: 1353 LAALQFEE 1360
            +   Q EE
Sbjct: 738  VRLRQQEE 745


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 264/1422 (18%), Positives = 534/1422 (37%), Gaps = 189/1422 (13%)

Query: 72   LLGVQFDQNVAHGIITEKPGVATKLLYQL---YIALQKKKKSGLTGVEMQTMQRLTNL-- 126
            LL  + D       I EK    T++ + +    + L ++K S   GVE++T++   NL  
Sbjct: 882  LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS--LGVEIKTLKEQLNLLS 939

Query: 127  RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKE 186
            R +  K +  +E                           V   L   + E     Q  KE
Sbjct: 940  RAEEAKKEQVEED------------------------NEVSSGLKQNYDEMSPAGQISKE 975

Query: 187  E-QRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVA 245
            E Q  FD+ K+   +R++     K+QAA+I   K    R  +  E    +K + + E   
Sbjct: 976  ELQHEFDLLKKENEQRKR-----KLQAALIN-RKELLQRVSRLEEELANLKDESKKEIPL 1029

Query: 246  DEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEY-IKKIQKRLEEDAFAR 304
             E ++ E  +++D + KE + K       +    L  T S+ E  ++ I+K LEE   A 
Sbjct: 1030 SETERGE--VEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087

Query: 305  EQRE---KRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVR----- 356
            EQ +   K+  + L D+    +  +    E Q I + +  S  +      +  V+     
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147

Query: 357  ---------HEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
                     H K  L +  +  EK+ E+ + K  Q+AL    A+ K+A+   +E+ L+E+
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEKEQLQ-KKLQEALTSRKAILKKAQE--KERHLREE 1204

Query: 408  RFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFF 467
                +    R Q ++++       I DQ+  L  +V +        I  KL    ++   
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES-------IDGKLPSTDQQESC 1257

Query: 468  NAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPS 527
            ++ P  E+   K    + ++  L                  N+  +W    E    L   
Sbjct: 1258 SSTPGLEEPLFKATEQHHTQPVLES----------------NLCPDWPSHSEDASALQGG 1301

Query: 528  NNC--ILGHILHRLAEK-SLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQ---- 580
             +   I   +    AEK  L  +  STT EL   + +   L + ++ +   + SL+    
Sbjct: 1302 TSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSH 1361

Query: 581  -------------KDFPIQILSIDTL------VQEAIQAFHDNEKVSEVLPIQKNDEEDA 621
                         +   +QI  ++ L      + E  +     E+    L  Q +++E A
Sbjct: 1362 EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1421

Query: 622  LPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANAD---KTPKAEEVKSSDSFL 678
            L  +Q EI E +D   +  A     E+  +   E +     +      K EE+   +S  
Sbjct: 1422 LTKIQTEIIEQED---LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI-GEESRA 1477

Query: 679  KLTTRAQLGA---KSEQLLKKGKSIPDVL-----LVDIIVNAINEIPVNQDCILDGFPMT 730
            K   + +L A     ++ LK+ KS+ + L      ++ +  ++ ++              
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537

Query: 731  LNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTS 790
            L +  LL+E     ++ +TE++R   +  +L+     S ++ L     D   L+   ++ 
Sbjct: 1538 LGRLALLQEER---DKLITEMDRSLLENQSLS-SSCESLKLALEGLTEDKEKLVKEIESL 1593

Query: 791  SMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQW 850
              S+    IAE   ++  H+++ +      Q  +   N  ++IQH          ++E  
Sbjct: 1594 KSSK----IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH----------VVEAV 1639

Query: 851  FSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELP 910
              E + +  K+ +    +   EK  +    E+ + K K+ K  + K+ +        +  
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699

Query: 911  LPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKR 970
                 PA     E  + +  S+ + K    + K + E    K +SL   K    E     
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759

Query: 971  KGSPKGK-SSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYV------NEPVPEEM 1023
            K   +G  S    +   +   + T+ +       P +   ++ + +      +E VP   
Sbjct: 1760 KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819

Query: 1024 PLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKR-PDHKQDFVA 1082
                    +   +  IN     +  L+E     +A L E +   +EF +   + K   ++
Sbjct: 1820 SANPAVSKDFSSHDEINNYLQQIDQLKER----IAGLEEEKQKNKEFSQTLENEKNTLLS 1875

Query: 1083 QWQADFNSLPDDLWDDEETKAE-LHQRVNDLRDRLWDICDARKEEAEQERLDIINE---- 1137
            Q       L   +  +E TK   L+Q++ +   R+  + +  +EE +     ++N+    
Sbjct: 1876 QISTKDGEL--KMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933

Query: 1138 -----SWLQDTLGMTMNHFFSLMQAELNRFQD-TKRLLQDYYWGMESKIPVEDNKRFTRI 1191
                 ++ QD     + +   L+++E+   +     L ++    ++ K  VE   R   +
Sbjct: 1934 NGSIGNYCQDVTDAQIKN--ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991

Query: 1192 PLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMD------NSLENVESN 1245
              +Q   K+         L   +    + V    K     + K+        +LE V++ 
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051

Query: 1246 FEADEKLVMDTWQQA----SLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKV 1301
             + D ++  +   QA      A + + + ++     + E     AD  +   ++ +NK+ 
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111

Query: 1302 KKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRK--------NELRVKIKEEHL 1353
             K   K+K ED + + +              E++  ++R+         E++V + ++  
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171

Query: 1354 AALQFEEIATQFRLELIK-TKALALLEDLVTKVVDVYKLMEK 1394
               Q +E       +L   TK+++ L+D   +V+D  K  E+
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 183/934 (19%), Positives = 372/934 (39%), Gaps = 134/934 (14%)

Query: 33  LLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGV 92
           L   VLH+    DD  +           N  + L+P L+        N     + E+   
Sbjct: 8   LANVVLHELSGDDDTDQ-----------NMRAPLDPELHQESDMEFNNTTQEDVQERLAY 56

Query: 93  ATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLR-HMIPRQTDFN 151
           A +L+ +L   +++K        ++Q  Q+   L+ +   +D   ++L+ H   + T  N
Sbjct: 57  AEQLVVELKDIIRQK--------DVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLN 108

Query: 152 LMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQ 211
                 + Q       E  +    E+L +  K   E+   +IEK     + + E+++ +Q
Sbjct: 109 KYIEEMKAQGGTVLPTEPQSE---EQLSKHDKSSTEEE-MEIEKIKHKLQEKEELISTLQ 164

Query: 212 AAI--IQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTS 269
           A +   Q  +PA + T    E ++ +  K++ ++  + I   +A + +  QA+++A +  
Sbjct: 165 AQLTQAQAEQPAQSST----EMEEFVMMKQQLQEKEEFISTLQAQLSQ-TQAEQAAQQVV 219

Query: 270 LDTAGQTTTDL---------LNTYSD-----DEYIKKIQKRLEEDAFAREQREKRRRKLL 315
            +   +  T +         L T +D      + ++ +Q++LEE   +   R  +   LL
Sbjct: 220 REKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR-AQVVDLL 278

Query: 316 MDQLIAHEAQEEAYREE----QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREK 371
             +L A E + +   ++    +  +  +R + +  R   +++  + E EV  +   F   
Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338

Query: 372 QHE-ERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCA 430
           Q E    L+ F+ A   +A L  +++    EQ  K +       +   Q   ++  S C 
Sbjct: 339 QEEMHHLLEQFEQAGQAQAEL--ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD 396

Query: 431 EILDQ---IVDLSTKVADYRMLTNNLIPYKLMHDWKEL--FFNAKPI--YEQASVKTLP- 482
            + DQ   ++    + A     T   +  +L    KE+  F N  P+  +E AS  + P 
Sbjct: 397 ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456

Query: 483 ------ANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHIL 536
                    + E +  L+KR +       E +N  G   L    ++ L   N  +   I 
Sbjct: 457 VYNEGTQAVTEENIASLQKRVV-------ELENEKGALLLSSIELEELKAENEKLSSQIT 509

Query: 537 HRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQE 596
              A+     R      E+   ++      ++ S + +    L+  F  +   +  L+ E
Sbjct: 510 LLEAQN----RTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565

Query: 597 AIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKES--------------QDPQHVFSAG 642
             +A  +   +   L  ++ +E D   + Q+E+K+               +D    F   
Sbjct: 566 MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM 625

Query: 643 PVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKK-GKSIP 701
           P  +  LP  E E   + +  +T  +EE+  +D+ ++L +  Q G KS   +   G+   
Sbjct: 626 PNEESSLPAVEKEQASTEHQSRT--SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 702 DVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRN-LTEVERKKAQKST 760
           D L  + + + I E+ +N     + +   L+     E+A    N N L E  +K A  ++
Sbjct: 684 DEL--ERLKSQILELELNFHKAQEIYEKNLD-----EKAKEISNLNQLIEEFKKNADNNS 736

Query: 761 LAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAE---ELSY--KTAHEDI--- 812
            A    + +   L S   +  ++ ++        MN   AE    L Y  +TAH+++   
Sbjct: 737 SAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796

Query: 813 ---SQRVAAENQDKDGD--QNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEI-D 866
              S  + A+++D   +  QN  D +Q +              FSE   ++  + +++ +
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDVQLQ--------------FSEQSTLIRSLQSQLQN 842

Query: 867 KES-LCEKVKEILTTEIAKKKNKVEKKLEEKEAE 899
           KES + E  + +    I+ K  ++ + L +KE E
Sbjct: 843 KESEVLEGAERV--RHISSKVEELSQALSQKELE 874



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 111/585 (18%), Positives = 242/585 (41%), Gaps = 80/585 (13%)

Query: 99   QLYIALQKKKKSGLTGVEMQT-MQRLTNLR-LQNMKSDTFQERLRHMIPRQTDFNLMRIT 156
            +L +  ++  K  L   ++Q  + R+T L+     + D  +ERL + +    + N     
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQL---AELNGSIGN 1939

Query: 157  YRFQEKYKHVKEDLAHLHFEKLER-FQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAII 215
            Y        +K +L     + L++   +L+EE++    EK  +    + E + KIQ A  
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999

Query: 216  QIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIK--KDLQAKESASKTSLDTA 273
            +    +  + L+ L  +K  + K+  +D     +K  AL +  K L+  ++ S+  L+  
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059

Query: 274  GQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ 333
             +     +      E+ KK Q  L       +  +    ++L D L   + ++E    ++
Sbjct: 2060 KENLAQAV------EHRKKAQAELASFKVLLDDTQSEAARVLADNL---KLKKELQSNKE 2110

Query: 334  LINRLMRQSQQ--ERRI-AVQLMHVRHEKEVLWQ-NRIFREKQHEERRLKDFQDALDREA 389
             +   M+Q  +  ERR+   +  H++ +K +  + + + REK H E  + + Q  L+++ 
Sbjct: 2111 SVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170

Query: 390  ALAKQAKIDFEEQFLK-------------------------EKRFHDQIAVERAQARYEK 424
               +Q + + +    +                         E++F D I  +  + R ++
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230

Query: 425  HYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPA- 483
                C+ + DQ+  +S  + + ++  +     +L HD K+++ +      Q   K     
Sbjct: 2231 --DNCSVLKDQLRQMSIHMEELKINIS-----RLEHD-KQIWESKAQTEVQLQQKVCDTL 2282

Query: 484  -NPSREQLTELEKRDLLDTNDYEEYKNMVGEW-ALPEEMVDNLPPSNNCILGHILHRLAE 541
               ++E L++LE+   L  +   E   +  E  +L +++ D         L + L +  E
Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD---------LSNSLEKCKE 2333

Query: 542  K--SLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPI---QILSIDTLVQE 596
            +  +L         ++ +       L   L     +   L ++  +   +I+S+ +  +E
Sbjct: 2334 QKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE 2393

Query: 597  AIQAF-------HDNEKVSEVLPIQKNDEEDALPVLQEEIKESQD 634
            AIQ         HD E + E+  +   +EE+ + VL+EE K++ D
Sbjct: 2394 AIQVAIAELRQQHDKE-IKELENLLSQEEEENI-VLEEENKKAVD 2436



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 191/960 (19%), Positives = 359/960 (37%), Gaps = 186/960 (19%)

Query: 49   EFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKK 108
            E ++  V+  KL+ F  L+  ++ L  QF+Q           G A   L   Y AL++K 
Sbjct: 322  EKMELEVAERKLS-FHNLQEEMHHLLEQFEQ----------AGQAQAELESRYSALEQKH 370

Query: 109  KSGL------------TGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRIT 156
            K+ +            TG E+Q+        L++  S   Q++    +  Q+   + ++ 
Sbjct: 371  KAEMEEKTSHILSLQKTGQELQSACDA----LKDQNSKLLQDKNEQAV--QSAQTIQQLE 424

Query: 157  YRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQ 216
             + Q+K K + + L  L  ++ E        Q  F        +    E +A +Q  +++
Sbjct: 425  DQLQQKSKEISQFLNRLPLQQHET-----ASQTSFPDVYNEGTQAVTEENIASLQKRVVE 479

Query: 217  IPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQT 276
            +        L ++E +++   K E E ++ +I   EA  +     +E +  + +D A + 
Sbjct: 480  LENEKGALLLSSIELEEL---KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKR 536

Query: 277  TTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
            ++    +  D       QK  E      E +E +     +   +  +  EEA   E L  
Sbjct: 537  SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA-DHEVLDQ 595

Query: 337  RLMRQSQQER----RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL- 391
            + M+Q + E     ++ V L     +  ++           +E+   + Q     E +L 
Sbjct: 596  KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLN 655

Query: 392  -----AKQAKIDFEEQF----------------LKEKRFHDQIAVERAQARYEKHYSVCA 430
                  K  K D ++                  LK +    ++   +AQ  YEK+    A
Sbjct: 656  DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKA 715

Query: 431  EI---LDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYE----QASVKTLPA 483
            +    L+Q+++   K AD     N+     L  +  +L    K +      +A VK L  
Sbjct: 716  KEISNLNQLIEEFKKNAD----NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEM 771

Query: 484  NPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA--E 541
            N     L E E++  LD      + N++ E                      +H L+   
Sbjct: 772  N-----LAEAERQRRLDYESQTAHDNLLTEQ---------------------IHSLSIEA 805

Query: 542  KSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQ----------ILSID 591
            KS   + E    EL    ++        S ++T++RSLQ     +          +  I 
Sbjct: 806  KSKDVKIEVLQNELDDVQLQ-------FSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858

Query: 592  TLVQEAIQAFHDNE----KVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDE 647
            + V+E  QA    E    K+ ++L  +K D E     ++E  K+ Q  +  FS       
Sbjct: 859  SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE--KDQQVTEISFSMT----- 911

Query: 648  VLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVD 707
                   E M+  N +K     E+K+    L L +RA+  AK EQ+ +  +    +    
Sbjct: 912  -------EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAE-EAKKEQVEEDNEVSSGLKQNY 963

Query: 708  IIVNAINEIPVNQDCILDGFPMTLNQ----AQLLEEALTGCNRNLTEVERKKAQKSTLAI 763
              ++   +I  +++ +   F +   +     + L+ AL      L  V R + + + L  
Sbjct: 964  DEMSPAGQI--SKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021

Query: 764  DPATSKEIPLPSPAFDFV----ILLDVSDTSSMSRMNDI-------IAE-ELSYKTAHED 811
            +  + KEIPL       V       + S+    S+  +I       I+E E+  +   +D
Sbjct: 1022 E--SKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079

Query: 812  ISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKI---NAEIDKE 868
            + +++AAE Q     Q L  Q+   +    +   LL+   SE + I+ K+   N +    
Sbjct: 1080 LEEKLAAEEQ----FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135

Query: 869  SLCEKVKEILTTE--------------------IAKKKNKVEKKLEEKEAEKKAAASLAE 908
                 VKE +                       + K+K +++KKL+E    +KA    A+
Sbjct: 1136 DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQ 1195



 Score = 32.3 bits (72), Expect = 4.3
 Identities = 45/242 (18%), Positives = 105/242 (43%), Gaps = 22/242 (9%)

Query: 160  QEKYKHVKEDLAHLHFEKLERFQKLKEEQRC----FDIEKQYLNRRRQNEIMAKIQAAII 215
            +E+   +KED   +  ++L +     EE +      + +KQ    + Q E+  ++Q  + 
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV--QLQQKVC 2279

Query: 216  QIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQ 275
               +  +   L  LE  + +    +     +E+ K E+ +K  L+ + +    SL+   +
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQ-----NELAKLESELKS-LKDQLTDLSNSLEKCKE 2333

Query: 276  TTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLI 335
               +L      +  I++ +  ++   F+ EQ E     L   + +     EE   +EQ I
Sbjct: 2334 QKGNL------EGIIRQQEADIQNSKFSYEQLET---DLQASRELTSRLHEEINMKEQKI 2384

Query: 336  NRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRL-KDFQDALDREAALAKQ 394
              L+   ++  ++A+  +  +H+KE+     +  +++ E   L ++ + A+D+   L + 
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMET 2444

Query: 395  AK 396
             K
Sbjct: 2445 LK 2446


>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
            isoform 1 [Homo sapiens]
          Length = 1112

 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 124/605 (20%), Positives = 219/605 (36%), Gaps = 123/605 (20%)

Query: 478  VKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPP----------- 526
            V TLP +     +  + K         E+     G  A+ + MVD LP            
Sbjct: 420  VTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQE 479

Query: 527  SNNCILGHILH--RLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFP 584
              +CIL  + H  +L  K +P   E          V     G+       +    QK  P
Sbjct: 480  RASCILQLVKHIQKLQAKDVPVAEE----------VSALFAGEL----NPVAPKAQKKVP 525

Query: 585  I-QILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGP 643
            + + L +D  + E               P+  ++ ED  P      +E + P+H      
Sbjct: 526  VPEGLDLDAWINE---------------PLSDSESEDERPRAVFHEEEQRRPKH------ 564

Query: 644  VSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDV 703
                  P    E  L+   +   + +E  ++  ++K +   Q         K+ +  P V
Sbjct: 565  -----RPSEADEEELARRREA--RKQEQANNPFYIKSSPSPQ---------KRYQDTPGV 608

Query: 704  LLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAI 763
              + ++     +I ++    + G PM+    +L EE      + L + +R+K +K     
Sbjct: 609  EHIPVV-----QIDLSVPLKVPGLPMSDQYVKLEEERRH--RQKLEKDKRRKKRKEKEKK 661

Query: 764  DPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDK 823
                   +P  S         D++    +    DI+ EE+            + ++  DK
Sbjct: 662  GKRRHSSLPTESDE-------DIAPAQQV----DIVTEEMP--------ENALPSDEDDK 702

Query: 824  DGDQNLR--DQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTE 881
            D +   R  D    + +   +  P+ +   +E      K    ++K+S   K KE     
Sbjct: 703  DPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE----- 757

Query: 882  IAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAK 941
              KK  + E+  E+K+ ++K A  L      TPPPAP P P       +   A      +
Sbjct: 758  --KKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAK----TE 811

Query: 942  GKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIV 1001
             + + +   G+ +  +  K KK     K+    K + + GK   KK P  S + +     
Sbjct: 812  AQGEEDDAEGQDQDKKSPKPKK-----KKHRKEKEERTKGKKKSKKQPPGSEEAA----- 861

Query: 1002 PQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLY 1061
             +P + G+ E     E +P E       Y  L ENSY+     +   L+ED    +A + 
Sbjct: 862  GEPVQNGAPE----EEQLPPES-----SYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVL 912

Query: 1062 EIRTS 1066
            E R+S
Sbjct: 913  ENRSS 917



 Score = 31.6 bits (70), Expect = 7.4
 Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 14/135 (10%)

Query: 1219 ETVTPKPKTKSVLKGKMDNSLENVESNFEADEKL-VMDTWQQASLAVSHMVAAEIHQRL- 1276
            E + P  +   V +   +N+L + E + + ++    +D      LA S  +  + H+   
Sbjct: 675  EDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTE 734

Query: 1277 --MEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKS----------PPMAE 1324
                 EK+    + K K P+    K  +KE  K+K+++K+ K +           P  A 
Sbjct: 735  TSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAP 794

Query: 1325 ATPVIVTTEEIAEIK 1339
            A   + +T+E  + K
Sbjct: 795  APAPVPSTDECEDAK 809


>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
          Length = 876

 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 54/201 (26%), Positives = 96/201 (47%), Gaps = 38/201 (18%)

Query: 225 TLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTY 284
           TL    A   +KKKKE   V+    + EAL ++ +  +ES +K+        T  ++N  
Sbjct: 548 TLSVQSASSTVKKKKET--VSKTTNRCEALSQRHMIYEESGNKS--------TAGIMNAE 597

Query: 285 SDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQ 344
           +  + + ++++       AREQREK               +EE  + E++  R++++S+ 
Sbjct: 598 AATKILTELRR------LAREQREK---------------EEEERQREEMQQRVIKKSKD 636

Query: 345 ERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAK-QAKIDFEEQF 403
             + AV      H K    Q      +Q+E ++ K + D  D+EA L K  AKI  +E+ 
Sbjct: 637 MAKEAVGGQAEDHLKLKDGQ------QQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEA 690

Query: 404 LKEKRFHDQIAVERAQARYEK 424
            K K+ H++I ++  Q R E+
Sbjct: 691 DKRKKEHERIMLQNLQERLER 711


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 69/300 (23%), Positives = 132/300 (44%), Gaps = 33/300 (11%)

Query: 135 TFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIE 194
           T Q     M P     ++M+    F ++   ++ D      ++LE  ++ +E ++    +
Sbjct: 498 TVQRNQMLMTPTSAPRSVMK---SFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQK 554

Query: 195 KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMK--KKKEAEDVADEIKKFE 252
            +   RRR  E+  K +  +         + L+A E  + MK  KKK+ E    +I +  
Sbjct: 555 VEEDKRRRLEEVKLKREERL--------RKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606

Query: 253 ALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRR 312
              K++  A+E A K +   A +   ++      +E  ++++         +E+ E+R +
Sbjct: 607 EKAKEERLAEEKAKKKA---AAKKMEEVEARRKQEEEARRLRW------LQQEEEERRHQ 657

Query: 313 KLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQ 372
           +LL  +    E ++E  R+     RL  Q +QERR   +    R E+E   Q R  +E+Q
Sbjct: 658 ELLQKK---KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 714

Query: 373 -------HEERRLKDFQDALDREAALAKQ-AKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
                   E+ RL+  ++  +RE AL  Q  ++  E +  K+K    ++A  + Q   EK
Sbjct: 715 LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 56/274 (20%), Positives = 133/274 (48%), Gaps = 30/274 (10%)

Query: 127 RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKE 186
           RL+N++     E+LR     +          R  E+ K  +E+      +  ER +++KE
Sbjct: 537 RLENLRRKEEAEQLRRQKVEEDK-------RRRLEEVKLKREERLRKVLQARERVEQMKE 589

Query: 187 EQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVA- 245
           E++   IE+++     + E   + + A  +  K A+ + ++ +EA++  K+++EA  +  
Sbjct: 590 EKKK-QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR--KQEEEARRLRW 646

Query: 246 ----DEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDA 301
               +E ++ + L++K  + ++   + + +                   ++ Q+R E++ 
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE-------------QREQERREQER 693

Query: 302 FAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEV 361
             +E+RE+ RR+    +     A++E  RE++ +     +  QER  A++L   + ++E+
Sbjct: 694 REQERREQERREQERREQERQLAEQERRREQERLQ--AERELQEREKALRLQKEQLQREL 751

Query: 362 LWQNRIFREKQHEERRLKDFQDALDREAALAKQA 395
             + +   +++  ER+L++ Q+   +EAA A +A
Sbjct: 752 EEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 785



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 99/509 (19%), Positives = 185/509 (36%), Gaps = 105/509 (20%)

Query: 874  VKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHV 933
            ++ +L  E+ +K    +K+  E EAE  AAA          P  P          + + +
Sbjct: 359  LERLLNVEVPQKVGSEQKEPPE-EAEPVAAAE---------PEVPENNGNNSWPHNDTEI 408

Query: 934  ASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADST 993
            A+ TP  K  P + +P       QE K  + +   +   S + K S  +   +       
Sbjct: 409  ANSTPNPK--PAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHL 466

Query: 994  DTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQ 1053
            +   +    QPP+  +      + P P               +  +  ++T L  ++ +Q
Sbjct: 467  EDEEL----QPPRSKTP-----SSPCPA--------------SKVVRPLRTFLHTVQRNQ 503

Query: 1054 HTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLR 1113
              ++      R+  + F+KR    +                     + K +  QR+ +LR
Sbjct: 504  -MLMTPTSAPRSVMKSFIKRNTPLR--------------------MDPKEKERQRLENLR 542

Query: 1114 DRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYY 1173
                     RKEEAEQ R   + E   +            L + +L R +  +++LQ   
Sbjct: 543  ---------RKEEAEQLRRQKVEEDKRR-----------RLEEVKLKREERLRKVLQARE 582

Query: 1174 WGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKG 1233
               + K   E+ K+       Q+D K     + R+               K K K+  K 
Sbjct: 583  RVEQMK---EEKKKQIEQKFAQIDEKTEKAKEERL------------AEEKAKKKAAAK- 626

Query: 1234 KMDNSLENVESNFEADEKLVMDTW-QQASLAVSHMVAAEIHQRLMEEEKEN--QPADPKE 1290
                 +E VE+  + +E+     W QQ      H    E+ Q+  EEE+E   + A+ K 
Sbjct: 627  ----KMEEVEARRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEEEQERLRKAAEAKR 679

Query: 1291 KSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKE 1350
             + Q    ++ ++E  +++QE ++ + +     E    +   E   E +R    R   + 
Sbjct: 680  LAEQ---REQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736

Query: 1351 EHLAALQFEEIATQFRLELIKTKALALLE 1379
            E    LQ E++  +   +  K +   L E
Sbjct: 737  EKALRLQKEQLQRELEEKKKKEEQQRLAE 765


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 174/913 (19%), Positives = 370/913 (40%), Gaps = 119/913 (13%)

Query: 107  KKKSGLTGVEMQTMQR-LTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKH 165
            K+K  L G E + M + +T L+ + +K DT    L+  + +++      +    Q++ K 
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS----AHVNSLAQDETKL 1132

Query: 166  VKEDLAHLHFEKLERFQKLKEEQRCFD--IEKQYL---NRRRQNEIMAKIQAAI--IQIP 218
                 AHL   +++  + LKE     +  +E + L   ++R+ +E+ +K++      Q  
Sbjct: 1133 K----AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSL 1188

Query: 219  KPASNRTLKALEAQKMMKKKKEAEDVADEI----KKFEALIKKDLQAKESASKTSLDTAG 274
            K +  ++ K+LE  K ++ KK +E++A ++    KK EAL+       E+ +   ++ + 
Sbjct: 1189 KSSHEKSNKSLE-DKSLEFKKLSEELAIQLDICCKKTEALL-------EAKTNELINISS 1240

Query: 275  QTTTDLLNTYSDDEY-IKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ 333
              T  +L+  S  ++   K+++ L        + E + R+L  +Q   + + ++A     
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA----- 1295

Query: 334  LINRLMRQSQQERRIAVQLMHVRHEKEVLW-----QNRIFREKQHEERRLK-DFQDALDR 387
              ++L  +  Q + +   +  +  EKE L      Q +   EK+    +LK +  + ++ 
Sbjct: 1296 -THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINA 1354

Query: 388  EAALAKQAKIDFEEQFLKEKRFHD-QIAVERAQARYEKHYSVCA----------EILDQI 436
               + ++ K    E     K+  D  + ++ + +  EK  ++ +          E+LDQ+
Sbjct: 1355 VTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQV 1414

Query: 437  VDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKR 496
             DLS KV    +    +   + + DW   F   K        K   +  ++ Q T  E +
Sbjct: 1415 QDLSFKVD--TLSKEKISALEQVDDWSNKFSEWK--------KKAQSRFTQHQNTVKELQ 1464

Query: 497  DLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELP 556
              L+    E Y+       L EE+ D      +C+ G +     +KS   + ES      
Sbjct: 1465 IQLELKSKEAYEKDEQINLLKEEL-DQQNKRFDCLKGEMED---DKSKMEKKESN----- 1515

Query: 557  SFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKN 616
                    L   L  +T  +  L+     + + I++L  E ++ ++  + +     +QK 
Sbjct: 1516 --------LETELKSQTARIMELEDHITQKTIEIESL-NEVLKNYNQQKDIEHKELVQKL 1566

Query: 617  DEEDALPVLQE-EIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSD 675
                 L   ++  +KE+++          S +   ET+ + +   N     K EE+K+ +
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626

Query: 676  SFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQ 735
              L+  + A+L     +  +K  +I   LL        +++   ++    G         
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLL--------SQMEEKEEQYKKG--------- 1669

Query: 736  LLEEALTGCNRNLTEVERKK--AQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMS 793
              E  L+  N  L E ER+    ++   +++ + S+ + +P  A +     +  +  S  
Sbjct: 1670 -TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 794  RMNDIIAEELSY----KTAHEDISQRVAAENQDKDGDQ-NLRDQIQHRIIGFLDNWPLLE 848
             +     E++S      T  E + QRV  E ++       +R Q Q R+I         E
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI----KLEHAE 1784

Query: 849  QWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKK--KNKVEKKLEEKEAEKKAAASL 906
                E ++++  +  E+++++  +K   I+   + K+  KN ++ K   +        +L
Sbjct: 1785 AKQHEDQSMIGHLQEELEEKN--KKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842

Query: 907  AELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGET 966
             E  L           +K KE+    V  K        +  + + K ++LQ+  G+   T
Sbjct: 1843 QEKELTC-----QILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897

Query: 967  ALKRKGSPKGKSS 979
             L  + + +   S
Sbjct: 1898 ELLEENTEEKSKS 1910



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 58/265 (21%), Positives = 117/265 (44%), Gaps = 45/265 (16%)

Query: 180 RFQKLKEEQRCFD-IEKQYLNRRRQNEIMAKIQAAI---IQIPKPASNRTLKALEAQKMM 235
           R QK K E+  F+ +EK     ++  E   K++A +   I+  +  S     +L+ Q++ 
Sbjct: 402 REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ-QELS 460

Query: 236 KKKKEAEDVA-----DEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTY---SDD 287
           + K+E  DV      ++I K + L +K+L  KE      L T  +   + +      S  
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520

Query: 288 EYIKKIQKRLEEDAFAREQREKRRRKLLMD---QLIAHEAQEEAYR------EEQLINRL 338
           EY+K  Q++ ++++ A E+ E +++ +L +   +L   + + E YR      E  L   L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580

Query: 339 MRQSQQERRIAV----------------------QLMHVRHEKEVLWQNRIFREKQHEER 376
                Q + +AV                      +L  ++H+++ LW  ++   KQ  + 
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640

Query: 377 RLKDFQDALDRE-AALAKQAKIDFE 400
            ++  ++  ++E   L K  +I F+
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQ 665



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 253/1407 (17%), Positives = 526/1407 (37%), Gaps = 237/1407 (16%)

Query: 128  LQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEE 187
            ++  K D   E   H I  Q   +LM+   +   + +   + L  ++  KLE   K +E+
Sbjct: 845  VEAQKKDVCTELDAHKIQVQ---DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901

Query: 188  QRCFDIEKQYL------NRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEA 241
             +   +EK+ +       ++++ EI+ +  +A     K  S   L      K   ++K+ 
Sbjct: 902  TKQILVEKENMILQMREGQKKEIEILTQKLSA-----KEDSIHILNEEYETKFKNQEKKM 956

Query: 242  EDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDA 301
            E V  + K+ +  +KK L  +E+                           K++K LE  A
Sbjct: 957  EKVKQKAKEMQETLKKKLLDQEA---------------------------KLKKELENTA 989

Query: 302  FAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEV 361
                Q+EK+    +++      AQ  +      ++RL   +Q+E+  ++  +H R   +V
Sbjct: 990  LELSQKEKQFNAKMLEM-----AQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDV 1043

Query: 362  L--WQNRIFREKQHEERRLKDFQ-DALDREAALAKQAKIDF---------EEQFLKEKRF 409
            +  W+ ++  ++  E + + + Q    ++E A  KQ  + F         E  +LKE+  
Sbjct: 1044 ISIWEKKL-NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV 1102

Query: 410  HDQIAVERAQARYEK---HYSVCAEILDQI--------VDLSTKVADYRMLTNNLIPYKL 458
                 +   Q + ++   H +  A+   ++        VDL+  + +   L   L+  K+
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162

Query: 459  MHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYE----EYKNMVGEW 514
            +         A+    + S  T     + E+   L+          E    E+K +  E 
Sbjct: 1163 L---------AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213

Query: 515  ALP----------------EEMVDNLPPSNNCILG---HILHRLAE------------KS 543
            A+                  E+++      N IL    H  HR  +              
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273

Query: 544  LPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEA---IQA 600
            L  +    T E  +  +        L  K   ++S++ D    +   + L +E     QA
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333

Query: 601  FHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSA 660
              + E     L  + ++  +A+ +++EE+KE +    + S      ++  + +    LS 
Sbjct: 1334 ASEKESCITQLKKELSENINAVTLMKEELKEKK--VEISSLSKQLTDLNVQLQNSISLSE 1391

Query: 661  NADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQ 720
                     +    +    L     L  K + L K+   I  +  VD   N  +E     
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKE--KISALEQVDDWSNKFSEWKKKA 1449

Query: 721  DCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDF 780
                     T+ + Q+             E++ K+A +    I+    +E+   +  FD 
Sbjct: 1450 QSRFTQHQNTVKELQIQ-----------LELKSKEAYEKDEQIN-LLKEELDQQNKRFDC 1497

Query: 781  VILLDVSDTSSMSRMNDIIAEELSYKTAH---------------EDISQRVAAENQDKDG 825
            +      D S M +    +  EL  +TA                E +++ +   NQ KD 
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI 1557

Query: 826  D-QNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEID--KESLCEKVKEILTTEI 882
            + + L  ++QH    F +     +    E E  ++ +  ++   K  L  K KE+    +
Sbjct: 1558 EHKELVQKLQH----FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613

Query: 883  AKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKG 942
            + K  + E K  E   E ++AA LAEL               +++  Q   A K      
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAEL---------------KRKAEQKIAAIKKQLLSQ 1658

Query: 943  KPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSP--VAI 1000
              + E  +           KKG  +   + + K +    +V + +    S ++S     I
Sbjct: 1659 MEEKEEQY-----------KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707

Query: 1001 VPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWE---LIENSYINTIKTVLRHLREDQHTVL 1057
            VP+  K  +    Y  +   +        Y E   +++ +     K + R  +E + TV 
Sbjct: 1708 VPRSAKNVA---AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764

Query: 1058 AYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLW 1117
            ++ +E+R  +QE L + +H +    + Q+    L ++L               + +++ +
Sbjct: 1765 SH-FEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL---------------EEKNKKY 1808

Query: 1118 DICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGME 1177
             +  A+  E E  + +I  +  L++         F  +Q  L   + T ++L+     ++
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENV--------FDDVQKTLQEKELTCQILEQKIKELD 1860

Query: 1178 SKIPVEDNKRFTRIPLVQLDSK-DNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMD 1236
            S +  +  K   R+ + +L SK +  ++  ++    + +  LE  T +     +++ K+ 
Sbjct: 1861 SCLVRQ--KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKL- 1917

Query: 1237 NSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMG 1296
              L N+E+     E  +    ++       +V  +   R++ +E + +    K++  Q  
Sbjct: 1918 --LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ-- 1973

Query: 1297 ANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAAL 1356
                 ++E  K++QED + K  S         ++        +++ EL + IKE    A 
Sbjct: 1974 ----EREEKIKQEQEDLELKHNS-----TLKQLMREFNTQLAQKEQELEMTIKETINKA- 2023

Query: 1357 QFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARY 1416
              +E+  +  LE  + +   LL+ +  K  D+ +  +++       E   T K+ D+   
Sbjct: 2024 --QEVEAEL-LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ 2080

Query: 1417 HIETSTKIQNELYLSQEDFFINGNIKV 1443
              E   K Q +  L QE+   N N+ +
Sbjct: 2081 LEELQKKYQQK--LEQEENPGNDNVTI 2105



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 104/524 (19%), Positives = 217/524 (41%), Gaps = 64/524 (12%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E+  ++  T+   Q +++   +++  H   +Q D  +       Q   K +K+ +  L  
Sbjct: 706  ELSVLKDQTDKMKQELEAKMDEQKNHHQ--QQVDSIIKEHEVSIQRTEKALKDQINQLEL 763

Query: 176  EKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMM 235
               ER + LKE Q   +  +  + R       A  +  + Q  + A++   KA E Q   
Sbjct: 764  LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823

Query: 236  KKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTY--SDDEYIKKI 293
             ++K  +   + I   + + + + Q K+    T LD       DL+      + E  +K+
Sbjct: 824  LQQKLLDLETERILLTKQVAEVEAQKKDVC--TELDAHKIQVQDLMQQLEKQNSEMEQKV 881

Query: 294  -------QKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQER 346
                   + +LE+     +++E+ ++ L+  + +  + +E   +E +++ + +   +   
Sbjct: 882  KSLTQVYESKLED---GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938

Query: 347  RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKE 406
             I  +    + + +     ++ ++ +  +  LK  +  LD+EA L K+ +    E   KE
Sbjct: 939  HILNEEYETKFKNQEKKMEKVKQKAKEMQETLK--KKLLDQEAKLKKELENTALELSQKE 996

Query: 407  KRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVAD--------YRMLTNNLIPYKL 458
            K+F+ ++ +E AQA         A I D +  L T   +        +R   N++I    
Sbjct: 997  KQFNAKM-LEMAQAN-------SAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI-- 1046

Query: 459  MHDW-KELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALP 517
               W K+L   A+ + E   +  +      +++ EL+++ LL   + EE    +  W L 
Sbjct: 1047 ---WEKKLNQQAEELQE---IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI-TW-LK 1098

Query: 518  EEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSG-KTTIL 576
            EE V       +  L  +  +L +KS           + S A     L   L   +  + 
Sbjct: 1099 EEGV-----KQDTTLNELQEQLKQKS---------AHVNSLAQDETKLKAHLEKLEVDLN 1144

Query: 577  RSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEED 620
            +SL+++  +Q    + LV+  + A  D  KVSE+    K  +E+
Sbjct: 1145 KSLKENTFLQ----EQLVELKMLAEEDKRKVSELTSKLKTTDEE 1184



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 83/439 (18%), Positives = 176/439 (40%), Gaps = 63/439 (14%)

Query: 40   KFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQ 99
            K E+     +  D  V      + S  E  ++ L  Q+D+     ++ +   ++ K+   
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCE-LLDQVQDLSFKV--- 1421

Query: 100  LYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRF 159
                L K+K S L  V+  +          N  S+  ++        Q     ++I    
Sbjct: 1422 --DTLSKEKISALEQVDDWS----------NKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469

Query: 160  QEKYKHVKEDLAHLHFEKLE----RFQKLKEEQRCFDIEKQYLNRRRQN-EIMAKIQAA- 213
            + K  + K++  +L  E+L+    RF  LK E    + +K  + ++  N E   K Q A 
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM---EDDKSKMEKKESNLETELKSQTAR 1526

Query: 214  IIQIPKPASNRTLKALEAQKMMKKKKEAEDV-----ADEIKKFEAL-IKKDLQAKES--- 264
            I+++    + +T++     +++K   + +D+       +++ F+ L  +KD + KE+   
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586

Query: 265  ---------ASKTSLDTAGQTTTDL-LNTYSDDEYIKKIQKRLEEDAFAREQREKRR--- 311
                     + K  L+T  +    + L+  S +E +K ++ RLE ++ A+    KR+   
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646

Query: 312  -----RKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEK----EVL 362
                 +K L+ Q+   E Q +   E  L     +  ++ER +     H+  EK    E  
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV-----HILEEKLKSVESS 1701

Query: 363  WQNRIFREKQHEERRLKDFQDALDREAALAK--QAKIDFEEQFLKEKRFHDQIAVERAQA 420
                +   +  +       Q+  D +  + K  + KI   ++ L EK    Q   +  + 
Sbjct: 1702 QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761

Query: 421  RYEKHYSVCAEILDQIVDL 439
                H+ +  +  ++++ L
Sbjct: 1762 TVSSHFEMRCQYQERLIKL 1780



 Score = 40.8 bits (94), Expect = 0.012
 Identities = 64/288 (22%), Positives = 134/288 (46%), Gaps = 31/288 (10%)

Query: 138 ERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEK-Q 196
           E L+  + RQ   NL++   R +E  +  KE    L  EK    ++L E  R  ++EK +
Sbjct: 282 ETLQQRVKRQE--NLLK---RCKETIQSHKEQCTLLTSEKEALQEQLDE--RLQELEKIK 334

Query: 197 YLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMK-----KKKEAEDVADEIKKF 251
            L+   + +++ +++ A   I +   ++ +   E ++ M      K++E   +   IK+ 
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394

Query: 252 EALIKKDLQAKESASKTS-------LDTAGQTTTDLLNTYSD-DEYIKKIQKRLEEDAFA 303
               ++  + KE + + +       L TA +T        ++ DE IK I+K  EE+  +
Sbjct: 395 TTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS 454

Query: 304 REQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLW 363
            +Q   R ++ ++D ++   ++E+  + ++L  + + + +QE    +Q      E+E   
Sbjct: 455 LQQELSRVKQEVVD-VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ----TREREFQE 509

Query: 364 QNRIFREKQHEE----RRLKDFQDALD-REAALAKQAKIDFEEQFLKE 406
           Q ++  EK   E     + K+ Q++L   E  L K+A +   E  L++
Sbjct: 510 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD 557



 Score = 32.3 bits (72), Expect = 4.3
 Identities = 56/278 (20%), Positives = 110/278 (39%), Gaps = 56/278 (20%)

Query: 1039 INTIKTVLR----HLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDD 1094
            IN ++ +L+    HL+E Q  V     +I+ S  E L++   K D    +Q+   +  + 
Sbjct: 758  INQLELLLKERDKHLKEHQAHVENLEADIKRSEGE-LQQASAKLDVFQSYQS---ATHEQ 813

Query: 1095 LWDDEETKAELHQRVNDLR-DRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFS 1153
                EE  A+L Q++ DL  +R+  +   +  E E ++ D+  E                
Sbjct: 814  TKAYEEQLAQLQQKLLDLETERI--LLTKQVAEVEAQKKDVCTE---------------- 855

Query: 1154 LMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPR 1213
             + A   + QD  + L+     ME K+     K  T++   +L+  +  + Q +  LV +
Sbjct: 856  -LDAHKIQVQDLMQQLEKQNSEMEQKV-----KSLTQVYESKLEDGNKEQEQTKQILVEK 909

Query: 1214 ISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIH 1273
             ++ L+    + K   +L  K+    +++                       H++  E  
Sbjct: 910  ENMILQMREGQKKEIEILTQKLSAKEDSI-----------------------HILNEEYE 946

Query: 1274 QRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQE 1311
             +   +EK+ +    K K  Q    KK+  +  K K+E
Sbjct: 947  TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 62/259 (23%), Positives = 117/259 (45%), Gaps = 33/259 (12%)

Query: 179 ERFQKLKEEQRCFDIEKQYLN---RRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMM 235
           +R + L+ ++    + +Q +    RRR  E+  K +  +         + L+A E  + M
Sbjct: 540 QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERL--------RKVLQARERVEQM 591

Query: 236 K--KKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKI 293
           K  KKK+ E    +I +     K++  A+E A K +   A +   ++      +E  +++
Sbjct: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKA---AAKKMEEVEARRKQEEEARRL 648

Query: 294 QKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLM 353
           +         +E+ E+R ++LL  +    E ++E  R+     RL  Q +QERR   +  
Sbjct: 649 R------WLQQEEEERRHQELLQKK---KEEEQERLRKAAEAKRLAEQREQERREQERRE 699

Query: 354 HVRHEKEVLWQNRIFREKQ-------HEERRLKDFQDALDREAALAKQ-AKIDFEEQFLK 405
             R E+E   Q R  +E+Q        E+ RL+  ++  +RE AL  Q  ++  E +  K
Sbjct: 700 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 759

Query: 406 EKRFHDQIAVERAQARYEK 424
           +K    ++A  + Q   EK
Sbjct: 760 KKEEQQRLAERQLQEEQEK 778



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 56/274 (20%), Positives = 133/274 (48%), Gaps = 30/274 (10%)

Query: 127 RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKE 186
           RL+N++     E+LR     +          R  E+ K  +E+      +  ER +++KE
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDK-------RRRLEEVKLKREERLRKVLQARERVEQMKE 593

Query: 187 EQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVA- 245
           E++   IE+++     + E   + + A  +  K A+ + ++ +EA++  K+++EA  +  
Sbjct: 594 EKKK-QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR--KQEEEARRLRW 650

Query: 246 ----DEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDA 301
               +E ++ + L++K  + ++   + + +                   ++ Q+R E++ 
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE-------------QREQERREQER 697

Query: 302 FAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEV 361
             +E+RE+ RR+    +     A++E  RE++ +     +  QER  A++L   + ++E+
Sbjct: 698 REQERREQERREQERREQERQLAEQERRREQERLQ--AERELQEREKALRLQKEQLQREL 755

Query: 362 LWQNRIFREKQHEERRLKDFQDALDREAALAKQA 395
             + +   +++  ER+L++ Q+   +EAA A +A
Sbjct: 756 EEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 789



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 102/514 (19%), Positives = 187/514 (36%), Gaps = 111/514 (21%)

Query: 874  VKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHV 933
            ++ +L  E+ +K    +K+  E EAE  AAA          P  P          + + +
Sbjct: 359  LERLLNVEVPQKVGSEQKEPPE-EAEPVAAAE---------PEVPENNGNNSWPHNDTEI 408

Query: 934  ASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADST 993
            A+ TP  K  P + +P       QE K  + +   +   S + K S  +   +       
Sbjct: 409  ANSTPNPK--PAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHL 466

Query: 994  DTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQ 1053
            +   +    QPP+  +      + P P               +  +  ++T L  ++ +Q
Sbjct: 467  EDEEL----QPPRSKTP-----SSPCPA--------------SKVVRPLRTFLHTVQRNQ 503

Query: 1054 HTVLAYLYEIRTSFQEFLKRP-----DHKQDFVAQWQADFNSLPDDLWDDEETKAELHQR 1108
              ++      R+  + F+KR      D K  FV + +                     QR
Sbjct: 504  -MLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER---------------------QR 541

Query: 1109 VNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRL 1168
            + +LR         RKEEAEQ R   + E   +            L + +L R +  +++
Sbjct: 542  LENLR---------RKEEAEQLRRQKVEEDKRR-----------RLEEVKLKREERLRKV 581

Query: 1169 LQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTK 1228
            LQ      + K   E+ K+       Q+D K     + R+               K K K
Sbjct: 582  LQARERVEQMK---EEKKKQIEQKFAQIDEKTEKAKEERL------------AEEKAKKK 626

Query: 1229 SVLKGKMDNSLENVESNFEADEKLVMDTW-QQASLAVSHMVAAEIHQRLMEEEKEN--QP 1285
            +  K      +E VE+  + +E+     W QQ      H    E+ Q+  EEE+E   + 
Sbjct: 627  AAAK-----KMEEVEARRKQEEEARRLRWLQQEEEERRHQ---ELLQKKKEEEQERLRKA 678

Query: 1286 ADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELR 1345
            A+ K  + Q    ++ ++E  +++QE ++ + +     E    +   E   E +R    R
Sbjct: 679  AEAKRLAEQ---REQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735

Query: 1346 VKIKEEHLAALQFEEIATQFRLELIKTKALALLE 1379
               + E    LQ E++  +   +  K +   L E
Sbjct: 736  ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 70/354 (19%), Positives = 155/354 (43%), Gaps = 51/354 (14%)

Query: 116 EMQTMQRLTNLRLQNMKSDTFQERLRHMIP--RQTDFNLMRITYRFQEKYKHVKEDLAHL 173
           E +  ++   +R Q  K    +ERLR      R+ +  + R   R +E+ K ++E    L
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337

Query: 174 HFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQK 233
             +K  R Q+ + +++   + +Q    R Q E M + +  + +  K    +  K  + ++
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397

Query: 234 MM----KKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEY 289
            M    ++ +E E+   E +K    ++K  + K+   +       + T D      ++E 
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE------KKTRDQEEKMQEEER 451

Query: 290 IKKIQKRL-EEDAFAREQREK----------------------RRRKLLMDQLIAHEAQE 326
           I++ +K++ EE+   REQ EK                       +++ L +Q    E +E
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511

Query: 327 EAYREEQLIN-------------RLMRQSQQERRIAVQLMHVRHEKEVLW--QNRIFREK 371
           + + +E+ I              R  +  +QE ++  Q   +R +++ +W  + R+ ++ 
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571

Query: 372 QHEERRLKDFQDAL-DREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
           Q +E++  D ++ + + E    ++ K+  EE+ ++E+    Q   E+ Q + EK
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 37/213 (17%), Positives = 103/213 (48%), Gaps = 8/213 (3%)

Query: 230 EAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEY 289
           + +KM +++K   +   E+++ E  +++  + +E   +           +      +++ 
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371

Query: 290 IKKIQKRLEEDAFAREQREKRR--RKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            ++ ++  E++   REQ +K R   + + +Q      +EE  RE++ +   + + ++E++
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKK 431

Query: 348 IAVQLMHVRHEKEVLWQNRIFREKQ----HEERRLKDFQDALDR-EAALAKQAKIDFEEQ 402
           +  Q    R ++E + +    RE++     EE  +++ ++ + + E  + +Q + ++++Q
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491

Query: 403 FLKEKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
            L E++       E+ Q + EK +    +I DQ
Sbjct: 492 RLPEQK-EKLWEQEKMQEQEEKIWEQEEKIRDQ 523



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 43/247 (17%), Positives = 116/247 (46%), Gaps = 17/247 (6%)

Query: 182 QKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEA 241
           +K++EE+R  + EK+    R + E+M + +  + +  +    +  K  E ++ M++++E 
Sbjct: 583 EKMREEERMREREKKM---REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE- 638

Query: 242 EDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDA 301
                  K +E   K   Q ++   +  L    +   +       ++  ++ +K  E++ 
Sbjct: 639 -------KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691

Query: 302 FAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEV 361
             ++ +E+ ++    +++   E+  E  ++ +    +MR+  QE ++  Q   ++ ++E 
Sbjct: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE--QEEKMQEQEEKMQEQEEE 749

Query: 362 LWQNR----IFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVER 417
           +W+         EK  E++RL + ++ L     + +Q KI  +E+ ++++    +   E+
Sbjct: 750 MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809

Query: 418 AQARYEK 424
            + + EK
Sbjct: 810 MRGQEEK 816



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 68/354 (19%), Positives = 134/354 (37%), Gaps = 40/354 (11%)

Query: 1014 YVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKR 1073
            Y+ E   E   L L  Y   I N     +K     L+E      +   EI+ + +E LKR
Sbjct: 198  YIEELTKERDALSLELYRNTITNE---ELKKKNAELQEKLPLAESEKSEIQLNVKE-LKR 253

Query: 1074 PDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEE----AEQ 1129
               +  F+   Q   N+L +++W  EE   E  +++    +++W   +  +E+     EQ
Sbjct: 254  KLERAKFLLP-QVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 312

Query: 1130 ERLDIINESWLQDTLGMTMNHFFSLM-QAELNRFQDTKRLLQDYYWGMESKIPVEDNKRF 1188
            E      E  L++           L  Q EL   ++  +  ++  W  E K+  ++ K +
Sbjct: 313  EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMW 372

Query: 1189 TRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEA 1248
             +   +    K   E +                  K + +     + D  L   E     
Sbjct: 373  RQEERLWEQEKQMREQE-----------------QKMRDQEERMWEQDERLREKEERMRE 415

Query: 1249 DEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPK--EKSPQMGANKKVKKEPP 1306
             EK+    W+Q              +++ E+EK+ +  + K  E+       KK+++E  
Sbjct: 416  QEKM----WEQVE-------KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464

Query: 1307 KKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEE 1360
              +++++K + +   M E        + + E K K   + K++E+     + EE
Sbjct: 465  TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518



 Score = 40.8 bits (94), Expect = 0.012
 Identities = 46/272 (16%), Positives = 126/272 (46%), Gaps = 24/272 (8%)

Query: 160 QEKYKHVKEDLAHLHFEKL-ERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIP 218
           ++K K  +++      EK+ E+ +K+++++  +  EK+   + +  E   ++     Q  
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE---QEE 551

Query: 219 KPASNRTLKALEAQKMMKKKKEAE----DVADEIKKFEALIKKDLQAKESASKTSLDTAG 274
           K          + ++M KK +E E    D  +++++ E + +++ + +E           
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE--------- 602

Query: 275 QTTTDLLNTYSD--DEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREE 332
               +++    +   E  +K+Q++ EE  + +E++ + + + + +Q      QEE   E+
Sbjct: 603 ----EMMREQEEKMQEQEEKMQEQ-EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657

Query: 333 QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALA 392
           Q +     +  +  ++  Q      E+++  Q ++ ++ Q +E++  D +   + E+   
Sbjct: 658 QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE 717

Query: 393 KQAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
           ++ K+  EE+ ++E+    Q   E+ Q + E+
Sbjct: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749



 Score = 39.3 bits (90), Expect = 0.035
 Identities = 51/259 (19%), Positives = 120/259 (46%), Gaps = 24/259 (9%)

Query: 176 EKLERF-QKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
           +K +R+ ++L +E+    +E  Y N     E+  K      ++P   S ++   L  +++
Sbjct: 193 KKADRYIEELTKERDALSLEL-YRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251

Query: 235 MKKKKEAEDVADEIKKF---EALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIK 291
            +K + A+ +  +++     E + +++ + +E   K                +  +E ++
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE--------KMWRQEERLR 303

Query: 292 KIQKRL---EEDAFAREQREKRRRKLLMDQ-LIAHEAQEEAYREEQLINRLMRQSQQERR 347
           + + ++   EE  + +E+R + + K L +Q     E +E   +EEQ+  +  +  +QE +
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363

Query: 348 IAVQLMHVRHEKEVLW-QNRIFREKQ-----HEERRLKDFQDALDREAALAKQAKI-DFE 400
           +  Q   +  ++E LW Q +  RE++      EER  +  +   ++E  + +Q K+ +  
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423

Query: 401 EQFLKEKRFHDQIAVERAQ 419
           E+  +EK+  +Q    R Q
Sbjct: 424 EKMREEKKMQEQEKKTRDQ 442



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 46/235 (19%), Positives = 101/235 (42%), Gaps = 32/235 (13%)

Query: 1093 DDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINES-WLQDTLGMTMNHF 1151
            + +W+ EE   E  +++ +  +++W   +  ++  EQ+RL    E  W  +         
Sbjct: 624  EKMWEQEEKMQEQEEKMWEQEEKMW---EQEEKMWEQQRLPEQKEKLWEHE--------- 671

Query: 1152 FSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLV 1211
              + + E  + Q+ K   Q+    ME K   ++ K + +  + + +S    E ++R    
Sbjct: 672  -KMQEQEKMQEQEEKIWEQE---KMEKKTQEQEKKTWDQEKMREEESMREREKKMR---- 723

Query: 1212 PRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAE 1271
                +  E      + +  ++ + +   E  E  +E +EK+    W+Q  L        E
Sbjct: 724  EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM----WEQQRLPEQKEKLWE 779

Query: 1272 IHQRLMEEEK----ENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPM 1322
             H+++ E+EK    E +  D +EK    G  +K++ +  K + +++K  G+   M
Sbjct: 780  -HEKMQEQEKIWEQEEKMRDQEEK--MRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 48/283 (16%), Positives = 136/283 (48%), Gaps = 18/283 (6%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKL-KEEQRCFDIEKQYLNRRRQNEIMAKI-QAAIIQI 217
           +EK +  +E +     +  E+ +K+ ++E++ ++ E++   ++R  E   K+ +   +Q 
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675

Query: 218 PKPASNRTLKALEAQKMMKKKKEAEDVA---DEIKKFEALIKKDLQAKESASKTSLDTAG 274
            +    +  K  E +KM KK +E E      +++++ E++ +++ + +E           
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK 735

Query: 275 QTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYR---- 330
               +      ++E  ++ +K  E++    EQ+    +K   ++L  HE  +E  +    
Sbjct: 736 MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK---EKLWEHEKMQEQEKIWEQ 792

Query: 331 EEQLINRLMRQSQQERRIAVQLMHVRHEKEVLW--QNRIFREKQH---EERRLKDFQDAL 385
           EE++ ++  +   QE ++  Q   +R ++E +W  + +++ +++    +E ++   ++ +
Sbjct: 793 EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKM 852

Query: 386 DREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSV 428
           + E    ++ K+  +E+ ++ +    +   E+ + + EK Y V
Sbjct: 853 E-EKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYCV 894



 Score = 35.0 bits (79), Expect = 0.67
 Identities = 50/261 (19%), Positives = 107/261 (40%), Gaps = 21/261 (8%)

Query: 1095 LWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSL 1154
            LW+ E+   E  Q++ D  +R+W+  +  +E+ E+ R     +  + + +          
Sbjct: 378  LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR----EQEKMWEQVEKMREEKKMQ 433

Query: 1155 MQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRI 1214
             Q +  R Q+ K   ++     E K+  E+     +   +Q   ++  E + +     R+
Sbjct: 434  EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493

Query: 1215 SISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKL--VMDTWQQASLAVSHMVAAEI 1272
                    P+ K K   + KM    E  E  +E +EK+    + W Q           E 
Sbjct: 494  --------PEQKEKLWEQEKMQ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 542

Query: 1273 HQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTT 1332
              ++ E+E++ +  + K    +    KK +++  +KK  D++ K +           +  
Sbjct: 543  EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ--EKKTWDQEEKMREEERMREREKKMRE 600

Query: 1333 EEIAEIKRKNELRVKIKEEHL 1353
            EE  E+ R+ E +++ +EE +
Sbjct: 601  EE--EMMREQEEKMQEQEEKM 619


>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
          Length = 514

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 68/330 (20%), Positives = 151/330 (45%), Gaps = 50/330 (15%)

Query: 116 EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
           EMQ  +     +   M+  T   + ++   RQ DF   ++  +F+E+ + ++ +L  +H 
Sbjct: 115 EMQLKKETIEEKKDRMREKTKLLKEKNEKERQ-DFVAEKLDQQFRERCEELRVELLSIHQ 173

Query: 176 EKL----------------------ERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAA 213
           +K+                      + F KL EE R    +++    RRQ E+M   +  
Sbjct: 174 KKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLG 233

Query: 214 IIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESA---SKTSL 270
           +      A   ++KA      + K++EA  V     + +   ++D+  K+ A   ++T L
Sbjct: 234 L-----NAQITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTIL 288

Query: 271 DTAGQTTTD-LLNTYSDDE--YIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAH----E 323
             A Q   + +   Y D++   +K +Q+ L++     ++++++R  ++ +Q I H    +
Sbjct: 289 QKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQ 348

Query: 324 AQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQD 383
            +EE   +E+  +R++ +  + +++A +   +R EKE     R   ++    R+L+  Q+
Sbjct: 349 RREEEKAQEKEFDRIL-EEDKAKKLAEKDKELRLEKEA---RRQLVDEVMCTRKLQ-VQE 403

Query: 384 ALDREAALAKQAKIDFEEQFLKEKRFHDQI 413
            L REA        + EE+ +++K  ++ +
Sbjct: 404 KLQREAK-------EQEERAMEQKHINESL 426



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 66/298 (22%), Positives = 125/298 (41%), Gaps = 51/298 (17%)

Query: 93  ATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDT-------FQERLRHMIP 145
           AT+LL +    L +   + +     Q M     L+ Q  K +T        QER+ H+  
Sbjct: 247 ATQLLKEEEARLVESNNAQIKHENEQDM-----LKKQKAKQETRTILQKALQERIEHIQQ 301

Query: 146 RQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNE 205
              D   + +        K V+  L  L  E  ++ QK ++  R   I  +YL +RR+ E
Sbjct: 302 EYRDEQDLNM--------KLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEE 353

Query: 206 IMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKF--EALIKKDLQAKE 263
                     +  +   +R L+  +A+K+ +K KE     +  ++   E +  + LQ +E
Sbjct: 354 ----------KAQEKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQE 403

Query: 264 SASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRL---EEDAFAREQR-EKRRRKLLMDQL 319
              + + +   +          + ++I +  K L   E++ FAR QR  +  RK L  Q+
Sbjct: 404 KLQREAKEQEERAM--------EQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQI 455

Query: 320 IAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERR 377
              +  +EA +EE       ++ + E  +A   M +   +EVL  +++  +  H  R+
Sbjct: 456 AYQQQSQEAEKEE-------KRREFEAGVAANKMCLDKVQEVLSTHQVLPQNIHPMRK 506


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 54/283 (19%), Positives = 135/283 (47%), Gaps = 16/283 (5%)

Query: 154 RITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAA 213
           R+  + +EK    +E +     +  E+ +K++E++    I +Q    RRQ E+M + +  
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE--KIREQEEKMRRQEEMMWEKEEK 411

Query: 214 IIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTA 273
           + +  +    +  K    ++MM +K+E     +E    +  I++  + ++   K      
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471

Query: 274 GQTTTDLLNTYSDDEYIKKIQKRL---EEDAFAREQREKRRRKLLMDQLIAHEAQEEAYR 330
            Q     +  +  +E I++ ++++   EE  + +E++   + K+  ++    + QEE +R
Sbjct: 472 RQEQEAKM--WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE--KRQEQEEMWR 527

Query: 331 EEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQH-EERRLKDFQDALDREA 389
           +E+ I       +Q+ +I  Q   +R ++E +W+     EK H +E ++++ ++ + R+ 
Sbjct: 528 QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ---EEKMHDQEEKIREQEEKVWRQE 584

Query: 390 ALAKQAKIDFEEQFLKEK-RFHDQIAVERAQARYEKHYSVCAE 431
              ++ +    EQ  +EK R  +++  E+ +   E+   +C +
Sbjct: 585 EKIREQEEKIREQ--EEKIREQEEMTQEQEEKMGEQEEKMCEQ 625



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 56/302 (18%), Positives = 137/302 (45%), Gaps = 26/302 (8%)

Query: 118 QTMQRLTNLRLQNMKSDTFQERLRHMIPRQT-DFNLMRITYRFQEKYKHVKEDLAHL--H 174
           + M     +R Q  K    +E++R    RQ  +  + R   + +E+ + ++E    +   
Sbjct: 445 EKMHEQEKIREQEEKRQE-EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503

Query: 175 FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
            EK+   +K++EE++  + E+ +    RQ E + + +    Q  K          + +KM
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMW----RQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKM 559

Query: 235 MKKKKEAEDVADEIKKFEALI-KKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKI 293
            +++++  D  ++I++ E  + +++ + +E   K           + +    +++  ++ 
Sbjct: 560 WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619

Query: 294 QKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLM 353
           +K  E++   +EQ EK RR            QEE  RE++   R     +QE +I  Q  
Sbjct: 620 EKMCEQEEKMQEQEEKMRR------------QEEKIREQEKKIR-----EQEEKIREQEE 662

Query: 354 HVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQI 413
            ++ ++E +W+      +Q E+ + ++ +     E    ++ ++  +E+ ++E + H + 
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722

Query: 414 AV 415
           A+
Sbjct: 723 AI 724



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 49/266 (18%), Positives = 120/266 (45%), Gaps = 35/266 (13%)

Query: 176 EKLERF-QKLKEEQRCFDIE--KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQ 232
           +K +R+ ++L +E+    +E  +  +      E  AK+Q  +  +    S   L   E +
Sbjct: 250 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 309

Query: 233 KMMKKKK----------EAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLN 282
           + +++ K          EA+ +  E++   A ++  ++  E  ++             LN
Sbjct: 310 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-------------LN 356

Query: 283 TYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQS 342
              +++  ++ +K  E +   +EQ EK R +   ++ I  + ++   +EE +  +  +  
Sbjct: 357 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMR 413

Query: 343 QQERRIAVQLMHVRHEKEVLWQN----RIFREKQHEERRLKDFQDALDREAALAKQAKID 398
           +QE  +  +   +R ++E++W+     R   EK HE+ ++++ ++    E  + +Q K  
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK-- 471

Query: 399 FEEQFLKEKRFHDQIAVERAQARYEK 424
            +EQ  K  R  ++I  +  + R ++
Sbjct: 472 RQEQEAKMWRQEEKIREQEEKIREQE 497



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 49/271 (18%), Positives = 122/271 (45%), Gaps = 22/271 (8%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
           +EK +  +E +        E+ +K++ ++     +++ +  RRQ E+M + +  I ++ +
Sbjct: 388 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM--RRQEEMMWEKEEKIRELEE 445

Query: 220 PASNRTL------KALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTA 273
               +        K  E +K+ +++K  E  A   ++ E + +++ + +E   K      
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE- 504

Query: 274 GQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ 333
                       + E I++ +KR E++   R++ + R ++ +  Q      QEE  R+++
Sbjct: 505 --------EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556

Query: 334 LINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAK 393
                 +  +QE ++  Q   +R ++E +W+      +Q E+ R ++ +     E    +
Sbjct: 557 -----EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQ 611

Query: 394 QAKIDFEEQFLKEKRFHDQIAVERAQARYEK 424
           + K+  +E+ + E+    Q   E+ + + EK
Sbjct: 612 EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEK 642



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 54/280 (19%), Positives = 128/280 (45%), Gaps = 31/280 (11%)

Query: 158 RFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQI 217
           R QE+    KE+      EK+   +K++E++     E++   + ++ E  AK+     +I
Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 486

Query: 218 PKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTT 277
            +       +  +  +  +K  E E + +E K+ E   ++++  +E   +   +   Q  
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQE---QEEMWRQEEKIREQEEIWRQKE 543

Query: 278 TDLLNTYSDDEYIKKIQKRL-EEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                 +  +E I+K ++++  ++    +Q EK R           E +E+ +R+E+ I 
Sbjct: 544 ----KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR-----------EQEEKVWRQEEKIR 588

Query: 337 RLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQA- 395
                 +QE +I  Q   +R E+E + Q +  +  + EE+  +  +   ++E  + +Q  
Sbjct: 589 ------EQEEKIREQEEKIR-EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEE 641

Query: 396 KIDFEEQFLKEK----RFHDQIAVERAQARYEKHYSVCAE 431
           KI  +E+ ++E+    R  +++  E+ +  +E+   +C +
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681



 Score = 31.6 bits (70), Expect = 7.4
 Identities = 44/264 (16%), Positives = 109/264 (41%), Gaps = 23/264 (8%)

Query: 1095 LWDDEETKAELHQRVNDLRDRLW---DICDARKEEAEQERLDIINESWLQDTLGMTMNHF 1151
            +W  EE   E  +++ +  +++W   +    +++  E+E+     E W Q+         
Sbjct: 479  MWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 538

Query: 1152 FSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLV 1211
            +   + +++  ++  R  ++  W  E K+  ++ K   +   V    +   E + +I   
Sbjct: 539  WR-QKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597

Query: 1212 PRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAE 1271
                   E +T + + K  +  + +   E  E   E +EK+     Q+  +        E
Sbjct: 598  EEKIREQEEMTQEQEEK--MGEQEEKMCEQEEKMQEQEEKM---RRQEEKIREQEKKIRE 652

Query: 1272 IHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVT 1331
              +++ E+E+  Q  + K         +K+ ++  K +++++K + +   M E       
Sbjct: 653  QEEKIREQEEMMQEQEEK----MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE------- 701

Query: 1332 TEEIAEIKRKNELRVKIKEEHLAA 1355
             +E+    R+ E +++  +EHL A
Sbjct: 702  -QEVR--LRQQEEKMQEHQEHLEA 722


>gi|92859701 myosin VI [Homo sapiens]
          Length = 1285

 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 67/302 (22%), Positives = 131/302 (43%), Gaps = 30/302 (9%)

Query: 213  AIIQIPKPASNRTLKALEAQ--KMMKKKKEAEDVADEIKK-FEALIKKDLQAKESASKTS 269
            ++++  KP  N+ +K LE     +M K K      ++I+K ++AL+K   +   +  K  
Sbjct: 858  SVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKK 917

Query: 270  LDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAY 329
                            + E +++IQ+ +E++   RE+ EKRRRK   ++ +  E + +  
Sbjct: 918  QQE------------EEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRK 965

Query: 330  REEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREA 389
            +EE+   R  R+  ++R  A     +  +KE   Q +   E++  +R L   + A     
Sbjct: 966  QEEE--ERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELA-LRIAQSEAE 1022

Query: 390  ALAKQAKIDF---EEQFLKEKRFHDQIAVERAQ--ARYEKHYSVCAEILDQIVDLST-KV 443
             ++ +A+ D         + K   +Q+A E ++  +R     +  A    +  DLS  K 
Sbjct: 1023 LISDEAQADLALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKY 1082

Query: 444  ADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTND 503
            A+ R   N     +L+   +E F     +Y     K      ++++ TE E+R      D
Sbjct: 1083 AELRDTINTSCDIELLAACREEFHRRLKVYHAWKSK------NKKRNTETEQRAPKSVTD 1136

Query: 504  YE 505
            Y+
Sbjct: 1137 YD 1138



 Score = 33.1 bits (74), Expect = 2.5
 Identities = 27/133 (20%), Positives = 61/133 (45%), Gaps = 10/133 (7%)

Query: 1187 RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPK----TKSVLKGKMDNSLENV 1242
            +F  +  V  D K     Q++      + IS++T+  K K    T+  ++ + D  +++ 
Sbjct: 852  KFNEVVSVLKDGKPEMNKQIK-----NLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSS 906

Query: 1243 ESNFEADEKLVMDTWQQASLA-VSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKV 1301
            E    A +K      +   L  +   +  E  +R  +E++  +  + +    +M A +K 
Sbjct: 907  EELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQ 966

Query: 1302 KKEPPKKKQEDKK 1314
            ++E  KK+++D+K
Sbjct: 967  EEEERKKREDDEK 979


>gi|109134347 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 78/398 (19%), Positives = 163/398 (40%), Gaps = 49/398 (12%)

Query: 116 EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAH-LH 174
           E QT Q    L L+ ++ +        ++ +  D   M++     +K + ++  +   L 
Sbjct: 76  EKQTQQEKLQLLLEELRGE--------LVEKTKDLEEMKLQILTPQKLELLRAQIQQELE 127

Query: 175 FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQ--------AAIIQIPKPASNRTL 226
               ERF+ L EE   +   +   N+ R      K +        A I+   K      +
Sbjct: 128 TPMRERFRNLDEEVEKY---RAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEI 184

Query: 227 KALEAQKM-MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYS 285
             LE  K  ++ +    D+  + K+ E L ++ +   +       + A +   +  N+ +
Sbjct: 185 ARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVA-ELKAEKENSEA 243

Query: 286 DDEYIKKIQKR--LEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQ 343
             E  ++IQ R   E  A  R    +++   L  + +  E Q  + +   LIN+L +  +
Sbjct: 244 QVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAER 303

Query: 344 QERRIAVQLMHVRHEKEV------LWQNRIFREKQHEERRLKDFQDALDREAALAKQAKI 397
           +   ++ ++  ++H  ++      L   R   E + E  +++   D L  +  + K A +
Sbjct: 304 EINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILK-AAV 362

Query: 398 DFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYK 457
           +  +  L EK   D+  + + QA  E+ Y     + D+ ++L  ++AD   +       K
Sbjct: 363 EHHKVLLVEK---DRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM-------K 412

Query: 458 LMHD-WKELFFNAKPIYEQASVKTLPANPSREQLTELE 494
           + HD W++   + K  YE+     L A+   E++T  E
Sbjct: 413 VEHDVWRQ---SEKDQYEE----KLRASQMAEEITRKE 443



 Score = 38.9 bits (89), Expect = 0.046
 Identities = 57/256 (22%), Positives = 114/256 (44%), Gaps = 43/256 (16%)

Query: 110 SGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITY-RFQEKYKHVKE 168
           SGLTG + +  + L + RL          R  H    + ++  ++  + R Q ++  ++ 
Sbjct: 22  SGLTGSQSEFQKMLIDERL----------RCEH---HKANYQTLKAEHTRLQNEHVKLQN 68

Query: 169 DLAHLHFEK---LERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
           +L HL  EK    E+ Q L EE R   +EK              ++   +QI  P     
Sbjct: 69  ELKHLFNEKQTQQEKLQLLLEELRGELVEK-----------TKDLEEMKLQILTPQKLEL 117

Query: 226 LKALEAQKMMKKKKEA-EDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTY 284
           L+A   Q++    +E   ++ +E++K+ A+  K L+ + +  K+  +   +    +L+  
Sbjct: 118 LRAQIQQELETPMRERFRNLDEEVEKYRAVYNK-LRYEHTFLKSEFEHQKEEYARILDE- 175

Query: 285 SDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQ 344
              +Y  +I  RLEED           ++ L +QL+  +  +++ R EQL    +   Q+
Sbjct: 176 GKIKYESEI-ARLEED-----------KEELRNQLLNVDLTKDSKRVEQLAREKVYLCQK 223

Query: 345 ERRIAVQLMHVRHEKE 360
            + +  ++  ++ EKE
Sbjct: 224 LKGLEAEVAELKAEKE 239


>gi|109134355 NY-REN-58 antigen [Homo sapiens]
          Length = 701

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 78/398 (19%), Positives = 163/398 (40%), Gaps = 49/398 (12%)

Query: 116 EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAH-LH 174
           E QT Q    L L+ ++ +        ++ +  D   M++     +K + ++  +   L 
Sbjct: 76  EKQTQQEKLQLLLEELRGE--------LVEKTKDLEEMKLQILTPQKLELLRAQIQQELE 127

Query: 175 FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQ--------AAIIQIPKPASNRTL 226
               ERF+ L EE   +   +   N+ R      K +        A I+   K      +
Sbjct: 128 TPMRERFRNLDEEVEKY---RAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEI 184

Query: 227 KALEAQKM-MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYS 285
             LE  K  ++ +    D+  + K+ E L ++ +   +       + A +   +  N+ +
Sbjct: 185 ARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVA-ELKAEKENSEA 243

Query: 286 DDEYIKKIQKR--LEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQ 343
             E  ++IQ R   E  A  R    +++   L  + +  E Q  + +   LIN+L +  +
Sbjct: 244 QVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAER 303

Query: 344 QERRIAVQLMHVRHEKEV------LWQNRIFREKQHEERRLKDFQDALDREAALAKQAKI 397
           +   ++ ++  ++H  ++      L   R   E + E  +++   D L  +  + K A +
Sbjct: 304 EINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILK-AAV 362

Query: 398 DFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYK 457
           +  +  L EK   D+  + + QA  E+ Y     + D+ ++L  ++AD   +       K
Sbjct: 363 EHHKVLLVEK---DRELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKM-------K 412

Query: 458 LMHD-WKELFFNAKPIYEQASVKTLPANPSREQLTELE 494
           + HD W++   + K  YE+     L A+   E++T  E
Sbjct: 413 VEHDVWRQ---SEKDQYEE----KLRASQMAEEITRKE 443



 Score = 38.9 bits (89), Expect = 0.046
 Identities = 57/256 (22%), Positives = 114/256 (44%), Gaps = 43/256 (16%)

Query: 110 SGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITY-RFQEKYKHVKE 168
           SGLTG + +  + L + RL          R  H    + ++  ++  + R Q ++  ++ 
Sbjct: 22  SGLTGSQSEFQKMLIDERL----------RCEH---HKANYQTLKAEHTRLQNEHVKLQN 68

Query: 169 DLAHLHFEK---LERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
           +L HL  EK    E+ Q L EE R   +EK              ++   +QI  P     
Sbjct: 69  ELKHLFNEKQTQQEKLQLLLEELRGELVEK-----------TKDLEEMKLQILTPQKLEL 117

Query: 226 LKALEAQKMMKKKKEA-EDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTY 284
           L+A   Q++    +E   ++ +E++K+ A+  K L+ + +  K+  +   +    +L+  
Sbjct: 118 LRAQIQQELETPMRERFRNLDEEVEKYRAVYNK-LRYEHTFLKSEFEHQKEEYARILDE- 175

Query: 285 SDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQ 344
              +Y  +I  RLEED           ++ L +QL+  +  +++ R EQL    +   Q+
Sbjct: 176 GKIKYESEI-ARLEED-----------KEELRNQLLNVDLTKDSKRVEQLAREKVYLCQK 223

Query: 345 ERRIAVQLMHVRHEKE 360
            + +  ++  ++ EKE
Sbjct: 224 LKGLEAEVAELKAEKE 239


>gi|148612801 KIAA1009 protein [Homo sapiens]
          Length = 1403

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 86/358 (24%), Positives = 148/358 (41%), Gaps = 52/358 (14%)

Query: 123  LTNLRLQNMKSDTFQERLRHMIPR----QTDFNLMR---------ITYRFQEKYKHVKED 169
            L  LR+   + D+  E ++ +       + DF  M+         I Y   EK   +K  
Sbjct: 788  LAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKI- 846

Query: 170  LAHLHFEKLERFQK----LKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
            L   H +++ R QK      E Q   D  K  L  R  NE + K++  I ++   + N +
Sbjct: 847  LEETHKQEISRLQKRLQWYAENQELLD--KDALRLREANEEIEKLKLEIEKLKAESGNPS 904

Query: 226  LKALEAQKMMKKKKEAE-----DVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDL 280
            ++    QK+  K K A+     D+  ++K+ E ++K+       A   +   AG T    
Sbjct: 905  IR----QKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDK- 959

Query: 281  LNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEE--AYREEQLINRL 338
             NT    E+++K  K+LE D   +++  K+  + +  Q    + Q E    ++EQL+   
Sbjct: 960  -NTV---EFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACK 1015

Query: 339  MRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKID 398
            + Q    R  A+       EKE+   + I    Q   R L+   D L  + A     K D
Sbjct: 1016 LNQHDSPRIKAL-------EKEL---DDIKEAHQITVRNLEAEIDVLKHQNAELDVKKND 1065

Query: 399  FEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKV----ADYRMLTNN 452
             +++  +   F  Q+    A+A+  +     A    +I DLS  V     D RM+ +N
Sbjct: 1066 KDDEDFQSIEF--QVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSN 1121



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 58/247 (23%), Positives = 99/247 (40%), Gaps = 24/247 (9%)

Query: 194 EKQYLNRRRQNEIMAK---IQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKK 250
           EK+ L  +R  E   K    QA I QI    S +  K LE  K+ + KK+ E    ++ +
Sbjct: 610 EKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKE-KELE-NKLEELKKQQEKELFKLNQ 667

Query: 251 FEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKR 310
              +++  L + E  +K           D +      E +K+IQK ++E     +  ++ 
Sbjct: 668 DNYILQAKLSSFEETNKKQRWLHFGEAADPVT----GEKLKQIQKEIQEQETLLQGYQQE 723

Query: 311 RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQ------ 364
             +L        + QE+  + E+   R+ +++Q        L    H+   L Q      
Sbjct: 724 NERLYNQ---VKDLQEQNKKNEE---RMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSE 777

Query: 365 ---NRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQAR 421
              N+ F +   E R  +  +D+L  +    KQ K   E  F K K+  DQ   + A   
Sbjct: 778 PTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVT 837

Query: 422 YEKHYSV 428
            EK Y +
Sbjct: 838 GEKLYEI 844


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 65/275 (23%), Positives = 130/275 (47%), Gaps = 30/275 (10%)

Query: 115  VEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLH 174
            VE Q  ++L   RL ++++D+ +E  R +  +Q      R+T   Q+   H++      H
Sbjct: 1399 VEQQNKRQLER-RLGDLQADS-EESQRAL--QQLKKKCQRLTAELQDTKLHLEGQQVRNH 1454

Query: 175  FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
                    +L+++QR FD E    +   Q E   K+Q   +Q  K        +L+ Q++
Sbjct: 1455 --------ELEKKQRRFDSELSQAHEEAQRE---KLQREKLQREKDMLLAEAFSLK-QQL 1502

Query: 235  MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQ 294
             +K  +      ++   EA ++ D+ ++ES  + SL    +   DL      +  +K  +
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVKKQLRDL------EAKVKDQE 1555

Query: 295  KRLEEDAFAREQRE--KRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQL 352
            + L+E A   +  E  K R ++ M+++    ++E   R+E++     RQS Q++   ++ 
Sbjct: 1556 EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEA--RQSCQKK---LKQ 1610

Query: 353  MHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDR 387
            M V+ E+E   + ++ REK+  E +L    D ++R
Sbjct: 1611 MEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1645



 Score = 38.9 bits (89), Expect = 0.046
 Identities = 43/190 (22%), Positives = 84/190 (44%), Gaps = 22/190 (11%)

Query: 166  VKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
            ++E L+ L  EK E   +L+E+Q               NE+M K +AA+ Q  +  +   
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQE------------DMNELMKKHKAAVAQASRDLAQIN 1777

Query: 226  LKALEAQKMMKKKKEAEDVADEIKK-----FEALIKKDLQAKESASKTSLDTAGQ-TTTD 279
                + ++  K+K+E ++    ++       ++++ K L +++ A    L+T  +   T 
Sbjct: 1778 DLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837

Query: 280  LLNTYSDDEYIKKIQKRLEED---AFAREQREKRRRKLLMDQL-IAHEAQEEAYREEQLI 335
            +    S    +K+  ++L E+     A E REK + K L  QL    E   E  R+E   
Sbjct: 1838 VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEA 1897

Query: 336  NRLMRQSQQE 345
            +R   + + +
Sbjct: 1898 SRKKHELEMD 1907



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 59/308 (19%), Positives = 132/308 (42%), Gaps = 42/308 (13%)

Query: 179  ERFQKLKEEQRCFDIEKQYLNRRRQNEIMAK--IQAAIIQIPKPASN------------R 224
            E  ++L+ E+   +++ QY   ++Q E+M    ++A +I+  +                +
Sbjct: 1315 ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLK 1374

Query: 225  TLKALEAQKMMKKK--KEAEDVADEIKKFEALIKK---DLQAKESASKTSLDTAGQTTTD 279
              +A+      KK+  +E ED  +  ++ +  +++   DLQA    S+ +L    +    
Sbjct: 1375 YERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434

Query: 280  LLNTYSD-----------DEYIKKIQKRLEED---AFAREQREKRRRKLLM---DQLIAH 322
            L     D           +  ++K Q+R + +   A    QREK +R+ L    D L+A 
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494

Query: 323  EAQEEAYREEQLINRLMRQSQQERRIAVQLMHV--RHEKEVLWQNRIFREKQHEERRLKD 380
                +   EE+ ++ +   +Q+   +  +L  +  +  K+     ++ ++ +  E ++KD
Sbjct: 1495 AFSLKQQLEEKDMD-IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKD 1553

Query: 381  FQDALDREAA---LAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIV 437
             ++ LD +A    + +QAK+  E +  + ++ H +    R +   E   S   ++    V
Sbjct: 1554 QEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1613

Query: 438  DLSTKVAD 445
             L  +  D
Sbjct: 1614 QLEEEYED 1621


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 65/275 (23%), Positives = 130/275 (47%), Gaps = 30/275 (10%)

Query: 115  VEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLH 174
            VE Q  ++L   RL ++++D+ +E  R +  +Q      R+T   Q+   H++      H
Sbjct: 1399 VEQQNKRQLER-RLGDLQADS-EESQRAL--QQLKKKCQRLTAELQDTKLHLEGQQVRNH 1454

Query: 175  FEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKM 234
                    +L+++QR FD E    +   Q E   K+Q   +Q  K        +L+ Q++
Sbjct: 1455 --------ELEKKQRRFDSELSQAHEEAQRE---KLQREKLQREKDMLLAEAFSLK-QQL 1502

Query: 235  MKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQ 294
             +K  +      ++   EA ++ D+ ++ES  + SL    +   DL      +  +K  +
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVKKQLRDL------EAKVKDQE 1555

Query: 295  KRLEEDAFAREQRE--KRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQL 352
            + L+E A   +  E  K R ++ M+++    ++E   R+E++     RQS Q++   ++ 
Sbjct: 1556 EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEA--RQSCQKK---LKQ 1610

Query: 353  MHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDR 387
            M V+ E+E   + ++ REK+  E +L    D ++R
Sbjct: 1611 MEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1645



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 62/279 (22%), Positives = 117/279 (41%), Gaps = 52/279 (18%)

Query: 166  VKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRT 225
            ++E L+ L  EK E   +L+E+Q               NE+M K +AA+ Q  +  +   
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQE------------DMNELMKKHKAAVAQASRDLAQ-- 1775

Query: 226  LKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYS 285
            +  L+AQ     K+                K++LQ K  A ++ ++   Q+  D      
Sbjct: 1776 INDLQAQLEEANKE----------------KQELQEKLQALQSQVEFLEQSMVDKSLVSR 1819

Query: 286  DDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYRE-EQLINRLMRQSQQ 344
             +  I++++ RLE      E+ + +R + L  +L   E  E+   E +Q I    R+ +Q
Sbjct: 1820 QEAKIRELETRLE-----FERTQVKRLESLASRL--KENMEKLTEERDQRIAAENREKEQ 1872

Query: 345  ERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFL 404
             +R+  QL   + E        + R++    R+  + +  L+   A  +  + D +  F 
Sbjct: 1873 NKRLQRQLRDTKEE-----MGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAF- 1926

Query: 405  KEKRFHD-QIAVERAQARYEKHYSVCAEILDQIVDLSTK 442
              KR  D Q A+E      E       ++++ + D+ TK
Sbjct: 1927 --KRIGDLQAAIEDEMESDENE-----DLINSLQDMVTK 1958



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 59/308 (19%), Positives = 132/308 (42%), Gaps = 42/308 (13%)

Query: 179  ERFQKLKEEQRCFDIEKQYLNRRRQNEIMAK--IQAAIIQIPKPASN------------R 224
            E  ++L+ E+   +++ QY   ++Q E+M    ++A +I+  +                +
Sbjct: 1315 ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLK 1374

Query: 225  TLKALEAQKMMKKK--KEAEDVADEIKKFEALIKK---DLQAKESASKTSLDTAGQTTTD 279
              +A+      KK+  +E ED  +  ++ +  +++   DLQA    S+ +L    +    
Sbjct: 1375 YERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434

Query: 280  LLNTYSD-----------DEYIKKIQKRLEED---AFAREQREKRRRKLLM---DQLIAH 322
            L     D           +  ++K Q+R + +   A    QREK +R+ L    D L+A 
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494

Query: 323  EAQEEAYREEQLINRLMRQSQQERRIAVQLMHV--RHEKEVLWQNRIFREKQHEERRLKD 380
                +   EE+ ++ +   +Q+   +  +L  +  +  K+     ++ ++ +  E ++KD
Sbjct: 1495 AFSLKQQLEEKDMD-IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKD 1553

Query: 381  FQDALDREAA---LAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIV 437
             ++ LD +A    + +QAK+  E +  + ++ H +    R +   E   S   ++    V
Sbjct: 1554 QEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1613

Query: 438  DLSTKVAD 445
             L  +  D
Sbjct: 1614 QLEEEYED 1621


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 47/201 (23%), Positives = 98/201 (48%), Gaps = 24/201 (11%)

Query: 228 ALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDD 287
           ALE  + ++K K A+ +  E ++ E   K++ + ++   +       +   ++L    ++
Sbjct: 716 ALEQLQQLEKAKAAK-LEQERREAEMRAKREEEERKRQEELR-----RQQEEILRRQQEE 769

Query: 288 EYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ--LINRL--MRQSQ 343
           E     +KR EE+  AR ++E+  R+    ++     +EE  R++Q   + RL   R+ +
Sbjct: 770 E-----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 824

Query: 344 QERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQF 403
           +ERR   +L+  + E+   W     RE++  +RRL++ +  ++ EA     A++  EE+ 
Sbjct: 825 EERRKQEELLRKQEEEAAKWA----REEEEAQRRLEENRLRMEEEA-----ARLRHEEEE 875

Query: 404 LKEKRFHDQIAVERAQARYEK 424
            K K    Q   E  + R ++
Sbjct: 876 RKRKELEVQRQKELMRQRQQQ 896



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 50/259 (19%), Positives = 118/259 (45%), Gaps = 37/259 (14%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
           +E+ +  +E+L     E L R Q+ + ++R    E++ L RR+Q E + + +   I + +
Sbjct: 745 EEEERKRQEELRRQQEEILRRQQEEERKRR----EEEELARRKQEEALRRQREQEIALRR 800

Query: 220 PASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTD 279
                  +  + ++ +++ +E     +E +K E L++K    +E A+K + +        
Sbjct: 801 QREEEERQ--QQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWARE-------- 847

Query: 280 LLNTYSDDEYIKKIQK---RLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                 ++E  +++++   R+EE+A      E+ R++  ++     E   +  ++++ + 
Sbjct: 848 ------EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALR 901

Query: 337 RLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQDAL 385
           RL +Q QQ++   ++L                 +  L    I + ++  ER+L++ Q   
Sbjct: 902 RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 961

Query: 386 DREAALAKQAKIDFEEQFL 404
            RE   A Q +   ++Q L
Sbjct: 962 QRELMKALQQQQQQQQQKL 980



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 45/247 (18%), Positives = 116/247 (46%), Gaps = 12/247 (4%)

Query: 170 LAHLHFEKLERFQKLKEEQRCFDIE-KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKA 228
           +  L  E+L R Q+L    +   ++ +Q+L +++  +++A+ Q A +   +      L  
Sbjct: 596 MGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALL-- 653

Query: 229 LEAQKMMKKKKEAEDVADEIKKFEALIKKDL--QAKESASKTSLDTAGQTTTDLLNTYSD 286
           L+  + +K +   +++   + +  ++       + + +AS+ ++   G      L+T + 
Sbjct: 654 LQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 713

Query: 287 DEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQER 346
              ++++Q+  +  A   EQ  +        +    + QEE  R+++ I R  ++ +++R
Sbjct: 714 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 773

Query: 347 RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKE 406
           R   +L   + E+ +  Q    RE++   RR ++ ++   +E AL +  +   EE+   E
Sbjct: 774 REEEELARRKQEEALRRQ----REQEIALRRQREEEERQQQEEALRRLEERRREEE---E 826

Query: 407 KRFHDQI 413
           +R  +++
Sbjct: 827 RRKQEEL 833



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 21/93 (22%), Positives = 42/93 (45%), Gaps = 1/93 (1%)

Query: 886  KNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQ 945
            K  +E++ ++K  +++    L +     PP  PP +P+++  +   +  S   +     Q
Sbjct: 1183 KQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMN-HSTLHSVFQTNQ 1241

Query: 946  SEAPHGKQESLQEGKGKKGETALKRKGSPKGKS 978
            S       E++Q GK KK +  ++   S  G S
Sbjct: 1242 SNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFS 1274


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 47/201 (23%), Positives = 98/201 (48%), Gaps = 24/201 (11%)

Query: 228 ALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDD 287
           ALE  + ++K K A+ +  E ++ E   K++ + ++   +       +   ++L    ++
Sbjct: 743 ALEQLQQLEKAKAAK-LEQERREAEMRAKREEEERKRQEELR-----RQQEEILRRQQEE 796

Query: 288 EYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ--LINRL--MRQSQ 343
           E     +KR EE+  AR ++E+  R+    ++     +EE  R++Q   + RL   R+ +
Sbjct: 797 E-----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 851

Query: 344 QERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQF 403
           +ERR   +L+  + E+   W     RE++  +RRL++ +  ++ EA     A++  EE+ 
Sbjct: 852 EERRKQEELLRKQEEEAAKWA----REEEEAQRRLEENRLRMEEEA-----ARLRHEEEE 902

Query: 404 LKEKRFHDQIAVERAQARYEK 424
            K K    Q   E  + R ++
Sbjct: 903 RKRKELEVQRQKELMRQRQQQ 923



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 50/259 (19%), Positives = 118/259 (45%), Gaps = 37/259 (14%)

Query: 160  QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
            +E+ +  +E+L     E L R Q+ + ++R    E++ L RR+Q E + + +   I + +
Sbjct: 772  EEEERKRQEELRRQQEEILRRQQEEERKRR----EEEELARRKQEEALRRQREQEIALRR 827

Query: 220  PASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTD 279
                   +  + ++ +++ +E     +E +K E L++K    +E A+K + +        
Sbjct: 828  QREEEERQ--QQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWARE-------- 874

Query: 280  LLNTYSDDEYIKKIQK---RLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                  ++E  +++++   R+EE+A      E+ R++  ++     E   +  ++++ + 
Sbjct: 875  ------EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALR 928

Query: 337  RLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQDAL 385
            RL +Q QQ++   ++L                 +  L    I + ++  ER+L++ Q   
Sbjct: 929  RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 988

Query: 386  DREAALAKQAKIDFEEQFL 404
             RE   A Q +   ++Q L
Sbjct: 989  QRELMKALQQQQQQQQQKL 1007



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 45/247 (18%), Positives = 116/247 (46%), Gaps = 12/247 (4%)

Query: 170 LAHLHFEKLERFQKLKEEQRCFDIE-KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKA 228
           +  L  E+L R Q+L    +   ++ +Q+L +++  +++A+ Q A +   +      L  
Sbjct: 623 MGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALL-- 680

Query: 229 LEAQKMMKKKKEAEDVADEIKKFEALIKKDL--QAKESASKTSLDTAGQTTTDLLNTYSD 286
           L+  + +K +   +++   + +  ++       + + +AS+ ++   G      L+T + 
Sbjct: 681 LQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 740

Query: 287 DEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQER 346
              ++++Q+  +  A   EQ  +        +    + QEE  R+++ I R  ++ +++R
Sbjct: 741 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 800

Query: 347 RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKE 406
           R   +L   + E+ +  Q    RE++   RR ++ ++   +E AL +  +   EE+   E
Sbjct: 801 REEEELARRKQEEALRRQ----REQEIALRRQREEEERQQQEEALRRLEERRREEE---E 853

Query: 407 KRFHDQI 413
           +R  +++
Sbjct: 854 RRKQEEL 860



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 21/93 (22%), Positives = 42/93 (45%), Gaps = 1/93 (1%)

Query: 886  KNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQ 945
            K  +E++ ++K  +++    L +     PP  PP +P+++  +   +  S   +     Q
Sbjct: 1210 KQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMN-HSTLHSVFQTNQ 1268

Query: 946  SEAPHGKQESLQEGKGKKGETALKRKGSPKGKS 978
            S       E++Q GK KK +  ++   S  G S
Sbjct: 1269 SNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFS 1301


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 47/201 (23%), Positives = 98/201 (48%), Gaps = 24/201 (11%)

Query: 228 ALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDD 287
           ALE  + ++K K A+ +  E ++ E   K++ + ++   +       +   ++L    ++
Sbjct: 722 ALEQLQQLEKAKAAK-LEQERREAEMRAKREEEERKRQEELR-----RQQEEILRRQQEE 775

Query: 288 EYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ--LINRL--MRQSQ 343
           E     +KR EE+  AR ++E+  R+    ++     +EE  R++Q   + RL   R+ +
Sbjct: 776 E-----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 830

Query: 344 QERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQF 403
           +ERR   +L+  + E+   W     RE++  +RRL++ +  ++ EA     A++  EE+ 
Sbjct: 831 EERRKQEELLRKQEEEAAKWA----REEEEAQRRLEENRLRMEEEA-----ARLRHEEEE 881

Query: 404 LKEKRFHDQIAVERAQARYEK 424
            K K    Q   E  + R ++
Sbjct: 882 RKRKELEVQRQKELMRQRQQQ 902



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 50/259 (19%), Positives = 118/259 (45%), Gaps = 37/259 (14%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
           +E+ +  +E+L     E L R Q+ + ++R    E++ L RR+Q E + + +   I + +
Sbjct: 751 EEEERKRQEELRRQQEEILRRQQEEERKRR----EEEELARRKQEEALRRQREQEIALRR 806

Query: 220 PASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTD 279
                  +  + ++ +++ +E     +E +K E L++K    +E A+K + +        
Sbjct: 807 QREEEERQ--QQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWARE-------- 853

Query: 280 LLNTYSDDEYIKKIQK---RLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                 ++E  +++++   R+EE+A      E+ R++  ++     E   +  ++++ + 
Sbjct: 854 ------EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALR 907

Query: 337 RLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQDAL 385
           RL +Q QQ++   ++L                 +  L    I + ++  ER+L++ Q   
Sbjct: 908 RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 967

Query: 386 DREAALAKQAKIDFEEQFL 404
            RE   A Q +   ++Q L
Sbjct: 968 QRELMKALQQQQQQQQQKL 986



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 45/247 (18%), Positives = 116/247 (46%), Gaps = 12/247 (4%)

Query: 170 LAHLHFEKLERFQKLKEEQRCFDIE-KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKA 228
           +  L  E+L R Q+L    +   ++ +Q+L +++  +++A+ Q A +   +      L  
Sbjct: 602 MGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALL-- 659

Query: 229 LEAQKMMKKKKEAEDVADEIKKFEALIKKDL--QAKESASKTSLDTAGQTTTDLLNTYSD 286
           L+  + +K +   +++   + +  ++       + + +AS+ ++   G      L+T + 
Sbjct: 660 LQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 719

Query: 287 DEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQER 346
              ++++Q+  +  A   EQ  +        +    + QEE  R+++ I R  ++ +++R
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779

Query: 347 RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKE 406
           R   +L   + E+ +  Q    RE++   RR ++ ++   +E AL +  +   EE+   E
Sbjct: 780 REEEELARRKQEEALRRQ----REQEIALRRQREEEERQQQEEALRRLEERRREEE---E 832

Query: 407 KRFHDQI 413
           +R  +++
Sbjct: 833 RRKQEEL 839



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 21/93 (22%), Positives = 42/93 (45%), Gaps = 1/93 (1%)

Query: 886  KNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQ 945
            K  +E++ ++K  +++    L +     PP  PP +P+++  +   +  S   +     Q
Sbjct: 1189 KQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMN-HSTLHSVFQTNQ 1247

Query: 946  SEAPHGKQESLQEGKGKKGETALKRKGSPKGKS 978
            S       E++Q GK KK +  ++   S  G S
Sbjct: 1248 SNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFS 1280


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 47/201 (23%), Positives = 98/201 (48%), Gaps = 24/201 (11%)

Query: 228 ALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDD 287
           ALE  + ++K K A+ +  E ++ E   K++ + ++   +       +   ++L    ++
Sbjct: 722 ALEQLQQLEKAKAAK-LEQERREAEMRAKREEEERKRQEELR-----RQQEEILRRQQEE 775

Query: 288 EYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQ--LINRL--MRQSQ 343
           E     +KR EE+  AR ++E+  R+    ++     +EE  R++Q   + RL   R+ +
Sbjct: 776 E-----RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 830

Query: 344 QERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQF 403
           +ERR   +L+  + E+   W     RE++  +RRL++ +  ++ EA     A++  EE+ 
Sbjct: 831 EERRKQEELLRKQEEEAAKWA----REEEEAQRRLEENRLRMEEEA-----ARLRHEEEE 881

Query: 404 LKEKRFHDQIAVERAQARYEK 424
            K K    Q   E  + R ++
Sbjct: 882 RKRKELEVQRQKELMRQRQQQ 902



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 50/259 (19%), Positives = 118/259 (45%), Gaps = 37/259 (14%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPK 219
           +E+ +  +E+L     E L R Q+ + ++R    E++ L RR+Q E + + +   I + +
Sbjct: 751 EEEERKRQEELRRQQEEILRRQQEEERKRR----EEEELARRKQEEALRRQREQEIALRR 806

Query: 220 PASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTD 279
                  +  + ++ +++ +E     +E +K E L++K    +E A+K + +        
Sbjct: 807 QREEEERQ--QQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWARE-------- 853

Query: 280 LLNTYSDDEYIKKIQK---RLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLIN 336
                 ++E  +++++   R+EE+A      E+ R++  ++     E   +  ++++ + 
Sbjct: 854 ------EEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALR 907

Query: 337 RLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQDAL 385
           RL +Q QQ++   ++L                 +  L    I + ++  ER+L++ Q   
Sbjct: 908 RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 967

Query: 386 DREAALAKQAKIDFEEQFL 404
            RE   A Q +   ++Q L
Sbjct: 968 QRELMKALQQQQQQQQQKL 986



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 45/247 (18%), Positives = 116/247 (46%), Gaps = 12/247 (4%)

Query: 170 LAHLHFEKLERFQKLKEEQRCFDIE-KQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKA 228
           +  L  E+L R Q+L    +   ++ +Q+L +++  +++A+ Q A +   +      L  
Sbjct: 602 MGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALL-- 659

Query: 229 LEAQKMMKKKKEAEDVADEIKKFEALIKKDL--QAKESASKTSLDTAGQTTTDLLNTYSD 286
           L+  + +K +   +++   + +  ++       + + +AS+ ++   G      L+T + 
Sbjct: 660 LQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 719

Query: 287 DEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQER 346
              ++++Q+  +  A   EQ  +        +    + QEE  R+++ I R  ++ +++R
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779

Query: 347 RIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKE 406
           R   +L   + E+ +  Q    RE++   RR ++ ++   +E AL +  +   EE+   E
Sbjct: 780 REEEELARRKQEEALRRQ----REQEIALRRQREEEERQQQEEALRRLEERRREEE---E 832

Query: 407 KRFHDQI 413
           +R  +++
Sbjct: 833 RRKQEEL 839



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 21/93 (22%), Positives = 42/93 (45%), Gaps = 1/93 (1%)

Query: 886  KNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQ 945
            K  +E++ ++K  +++    L +     PP  PP +P+++  +   +  S   +     Q
Sbjct: 1189 KQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMN-HSTLHSVFQTNQ 1247

Query: 946  SEAPHGKQESLQEGKGKKGETALKRKGSPKGKS 978
            S       E++Q GK KK +  ++   S  G S
Sbjct: 1248 SNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFS 1280


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 48/220 (21%), Positives = 100/220 (45%), Gaps = 19/220 (8%)

Query: 291  KKIQKRLEEDAFAREQREKR---RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            K+ Q++ E +    EQ+  +    + LL +QL   +A+ E Y E + +   +   +QE  
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELE 921

Query: 348  IAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
              +  M  R E+E     ++  E++   +++ D ++ L+ E A  ++ +++      K K
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 408  RFHDQIAV-ERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF 466
            +  D+I V +    +  K   +  E   +I DL+T +A+      NL   K  H+     
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHE----- 1033

Query: 467  FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEE 506
                 +  +  V+      SR++L +L+++   D +D+ E
Sbjct: 1034 ----SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 64/291 (21%), Positives = 138/291 (47%), Gaps = 24/291 (8%)

Query: 153  MRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQA 212
            +R+  + QE  + + E  A L  E+ +R Q+L+ E++    +   L  + + E  A+ + 
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK- 968

Query: 213  AIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDT 272
              +Q+ K  +   +K LE + ++      +D  +++ K   L+++ + +  + +    + 
Sbjct: 969  --LQLEKVTAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERI-SDLTTNLAEEEE 1020

Query: 273  AGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREE 332
              +  T L N +  +  I +++ RL+++  +R++ EK +RKL  D    HE  + A  + 
Sbjct: 1021 KAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE--QIADLQA 1076

Query: 333  QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL- 391
            Q+    M+ +++E  +   L   R + E+  +N   ++ +  E  + D Q+ LD E A  
Sbjct: 1077 QIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 392  --AKQAKIDFEEQF--LK---EKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A++ K D  E+   LK   E         +  +A+ E+  +V  + LD+
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 73/346 (21%), Positives = 151/346 (43%), Gaps = 39/346 (11%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E++  +R    +++ MK+    E L   +    D  L R+    Q      + DL     
Sbjct: 1529 ELEKSKRALETQMEEMKTQL--EELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDE 1585

Query: 176  EKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMA----KIQAAIIQIPKPASNRTLKALEA 231
            +  E+ ++L+ +   ++ E +  + R+Q  + A    K++  +  +   A +      EA
Sbjct: 1586 QNEEKRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 232  QKMMKK-KKEAEDVADEIKKFEALIKKD---LQAKESASKTSLDTAGQTTTDLLNTYSDD 287
             K ++K + + +D   E++  +A   +D     AKE+  K     A     DL+    D 
Sbjct: 1644 IKQLRKLQAQMKDFQRELE--DARASRDEIFATAKENEKK-----AKSLEADLMQLQEDL 1696

Query: 288  EYIKKIQKR--LEEDAFARE-----------QREKRRRKLLMDQLIAHEAQEEAYREEQL 334
               ++ +K+  LE++  A E           Q EKRR +  + QL   E +EE    E +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL-EEELEEEQGNMEAM 1755

Query: 335  INRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERR--LKDFQDALD---REA 389
             +R+ + +QQ  +++ +L   R   +     R   E+Q++E R  L + + A+    +  
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815

Query: 390  ALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A +AKI   E+ ++++    Q A +  + + +K   +  ++ D+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 164/951 (17%), Positives = 357/951 (37%), Gaps = 139/951 (14%)

Query: 126  LRLQNMKSDTFQERLRHMIPRQTDFN--LMRITYRFQEKYKHVKEDLAHLHFEKLERFQK 183
            L+L+ + ++   ++L   I    D N  L +     +E+   +  +LA    EK +   K
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-EKAKNLTK 1027

Query: 184  LKEEQRCF------DIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKK 237
            LK +           ++K+  +R+   ++  K++       +  ++   +  E +  + K
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 238  KKEAEDVA-----DEIKKFEALIKK---------DLQAKESASKTSLDTAGQTTTDLLNT 283
            K+E    A     DEI +    +KK         DLQ    + + + + A +   DL   
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1144

Query: 284  YSDDEYIK-KIQKRLEEDAFAREQREKRR------RKLLMDQLIAHEAQEEAYREE--QL 334
              + E +K +++  L+  A  +E R KR       +K L ++  +HEAQ +  R++  Q 
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 335  INRLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQD 383
            +  L  Q +Q +R    L             +  E  VL Q +  +E +H++++L+    
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--QEVEHKKKKLEAQVQ 1262

Query: 384  ALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKV 443
             L  + +  ++A+ +     L +K    Q  VE       +      ++   +  LS+++
Sbjct: 1263 ELQSKCSDGERARAE-----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317

Query: 444  ADYRMLTNNLIPYKL---------------MHDWKELFFNAKPIYEQ-ASVKTLPANPSR 487
             D + L       KL               + D  +    AK   E+  S   +  + S+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377

Query: 488  EQLTE----LEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA--- 540
            ++L +    +E  +       +E +N+  ++       D L  + N +   +   +    
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 541  -EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQ 599
             ++ L    E    +      +   +    + +     +  ++   + LS+   ++EA++
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 600  AFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLS 659
            A  + E+ +++L  +  D   +   + + + E +  +                E +T L 
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QMEEMKTQLE 1549

Query: 660  ANADKTPKAEEVK----SSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVL------LVD-- 707
               D+    E+ K     +   LK      L A+ EQ  +K + +   L      L D  
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 708  -----------IIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKA 756
                        +   + ++ +  D  + G    + Q + L+  +    R   E+E  +A
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR---ELEDARA 1666

Query: 757  QKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMN---DIIAEELSYKTAHEDIS 813
             +  +    AT+KE    + + +  ++    D ++  R     D+  EEL+     E+++
Sbjct: 1667 SRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-----EELA 1718

Query: 814  QRVAAENQDKDGDQNLR---DQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESL 870
              ++  N  +D  + L     Q++  +     N   +     +      +++ E+  E  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 871  CEKVKEILTTEIAKKKNKVEKKLEEKE--AEKKAAASLAELPLPTPPPAPPPEPEKEKEI 928
              +  E    ++ ++  ++  KL E E   + K  +++A L           E + E+E 
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----EAKIAQLEEQVEQEA 1834

Query: 929  HQSHVASKTPTAKGKP--------QSEAPHGKQESLQEGKGKKGETALKRK 971
             +   A+K+   K K         + E    +Q   Q  KG      LKR+
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 84/449 (18%), Positives = 164/449 (36%), Gaps = 71/449 (15%)

Query: 1042 IKTVLRHLREDQHTVLAYLYEIRTSFQEF--------LKRPDHK---QDFVAQWQA---- 1086
            + T LR L E+++++   L E   + Q          ++  D K   QDF +  +A    
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 1087 --DFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTL 1144
               F    ++L    E KA  + ++   ++RL       ++E +   +D+ N+  L   L
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-------QQELDDLVVDLDNQRQLVSNL 1446

Query: 1145 GMTMNHFFSLMQAELN----------------RFQDTKRL--LQDYYWGMESKIPVEDNK 1186
                  F  L+  E N                R ++TK L   +     +E+K  +E   
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506

Query: 1187 RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTK-----------SVLKGKM 1235
            +  +  +  L S  +   +  +  + +   +LET   + KT+              K ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1236 DNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQ- 1294
            + +++ ++  FE D +   D   +           E    L +E K+   A   +K  + 
Sbjct: 1566 EVNMQALKGQFERDLQ-ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 1295 ------MGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKI 1348
                  + A+  +K      KQ  K          E      + +EI    ++NE + K 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 1349 KEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEK---------WLGER 1399
             E  L  LQ +  A +   +    +   L E+L + +     L ++          L E 
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1400 YLNEMASTEKLTDVARYHIETSTKIQNEL 1428
               E  + E ++D  R   + + ++ NEL
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 48/220 (21%), Positives = 100/220 (45%), Gaps = 19/220 (8%)

Query: 291  KKIQKRLEEDAFAREQREKR---RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            K+ Q++ E +    EQ+  +    + LL +QL   +A+ E Y E + +   +   +QE  
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELE 928

Query: 348  IAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
              +  M  R E+E     ++  E++   +++ D ++ L+ E A  ++ +++      K K
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 408  RFHDQIAV-ERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF 466
            +  D+I V +    +  K   +  E   +I DL+T +A+      NL   K  H+     
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHE----- 1040

Query: 467  FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEE 506
                 +  +  V+      SR++L +L+++   D +D+ E
Sbjct: 1041 ----SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 64/291 (21%), Positives = 138/291 (47%), Gaps = 24/291 (8%)

Query: 153  MRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQA 212
            +R+  + QE  + + E  A L  E+ +R Q+L+ E++    +   L  + + E  A+ + 
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK- 975

Query: 213  AIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDT 272
              +Q+ K  +   +K LE + ++      +D  +++ K   L+++ + +  + +    + 
Sbjct: 976  --LQLEKVTAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERI-SDLTTNLAEEEE 1027

Query: 273  AGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREE 332
              +  T L N +  +  I +++ RL+++  +R++ EK +RKL  D    HE  + A  + 
Sbjct: 1028 KAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE--QIADLQA 1083

Query: 333  QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL- 391
            Q+    M+ +++E  +   L   R + E+  +N   ++ +  E  + D Q+ LD E A  
Sbjct: 1084 QIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 392  --AKQAKIDFEEQF--LK---EKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A++ K D  E+   LK   E         +  +A+ E+  +V  + LD+
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 73/346 (21%), Positives = 151/346 (43%), Gaps = 39/346 (11%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E++  +R    +++ MK+    E L   +    D  L R+    Q      + DL     
Sbjct: 1536 ELEKSKRALETQMEEMKTQL--EELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDE 1592

Query: 176  EKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMA----KIQAAIIQIPKPASNRTLKALEA 231
            +  E+ ++L+ +   ++ E +  + R+Q  + A    K++  +  +   A +      EA
Sbjct: 1593 QNEEKRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 232  QKMMKK-KKEAEDVADEIKKFEALIKKD---LQAKESASKTSLDTAGQTTTDLLNTYSDD 287
             K ++K + + +D   E++  +A   +D     AKE+  K     A     DL+    D 
Sbjct: 1651 IKQLRKLQAQMKDFQRELE--DARASRDEIFATAKENEKK-----AKSLEADLMQLQEDL 1703

Query: 288  EYIKKIQKR--LEEDAFARE-----------QREKRRRKLLMDQLIAHEAQEEAYREEQL 334
               ++ +K+  LE++  A E           Q EKRR +  + QL   E +EE    E +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL-EEELEEEQGNMEAM 1762

Query: 335  INRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERR--LKDFQDALD---REA 389
             +R+ + +QQ  +++ +L   R   +     R   E+Q++E R  L + + A+    +  
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822

Query: 390  ALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A +AKI   E+ ++++    Q A +  + + +K   +  ++ D+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 164/951 (17%), Positives = 357/951 (37%), Gaps = 139/951 (14%)

Query: 126  LRLQNMKSDTFQERLRHMIPRQTDFN--LMRITYRFQEKYKHVKEDLAHLHFEKLERFQK 183
            L+L+ + ++   ++L   I    D N  L +     +E+   +  +LA    EK +   K
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-EKAKNLTK 1034

Query: 184  LKEEQRCF------DIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKK 237
            LK +           ++K+  +R+   ++  K++       +  ++   +  E +  + K
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 238  KKEAEDVA-----DEIKKFEALIKK---------DLQAKESASKTSLDTAGQTTTDLLNT 283
            K+E    A     DEI +    +KK         DLQ    + + + + A +   DL   
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1151

Query: 284  YSDDEYIK-KIQKRLEEDAFAREQREKRR------RKLLMDQLIAHEAQEEAYREE--QL 334
              + E +K +++  L+  A  +E R KR       +K L ++  +HEAQ +  R++  Q 
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 335  INRLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQD 383
            +  L  Q +Q +R    L             +  E  VL Q +  +E +H++++L+    
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--QEVEHKKKKLEAQVQ 1269

Query: 384  ALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKV 443
             L  + +  ++A+ +     L +K    Q  VE       +      ++   +  LS+++
Sbjct: 1270 ELQSKCSDGERARAE-----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324

Query: 444  ADYRMLTNNLIPYKL---------------MHDWKELFFNAKPIYEQ-ASVKTLPANPSR 487
             D + L       KL               + D  +    AK   E+  S   +  + S+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

Query: 488  EQLTE----LEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA--- 540
            ++L +    +E  +       +E +N+  ++       D L  + N +   +   +    
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 541  -EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQ 599
             ++ L    E    +      +   +    + +     +  ++   + LS+   ++EA++
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 600  AFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLS 659
            A  + E+ +++L  +  D   +   + + + E +  +                E +T L 
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QMEEMKTQLE 1556

Query: 660  ANADKTPKAEEVK----SSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVL------LVD-- 707
               D+    E+ K     +   LK      L A+ EQ  +K + +   L      L D  
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 708  -----------IIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKA 756
                        +   + ++ +  D  + G    + Q + L+  +    R   E+E  +A
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR---ELEDARA 1673

Query: 757  QKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMN---DIIAEELSYKTAHEDIS 813
             +  +    AT+KE    + + +  ++    D ++  R     D+  EEL+     E+++
Sbjct: 1674 SRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-----EELA 1725

Query: 814  QRVAAENQDKDGDQNLR---DQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESL 870
              ++  N  +D  + L     Q++  +     N   +     +      +++ E+  E  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 871  CEKVKEILTTEIAKKKNKVEKKLEEKE--AEKKAAASLAELPLPTPPPAPPPEPEKEKEI 928
              +  E    ++ ++  ++  KL E E   + K  +++A L           E + E+E 
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----EAKIAQLEEQVEQEA 1841

Query: 929  HQSHVASKTPTAKGKP--------QSEAPHGKQESLQEGKGKKGETALKRK 971
             +   A+K+   K K         + E    +Q   Q  KG      LKR+
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 84/449 (18%), Positives = 164/449 (36%), Gaps = 71/449 (15%)

Query: 1042 IKTVLRHLREDQHTVLAYLYEIRTSFQEF--------LKRPDHK---QDFVAQWQA---- 1086
            + T LR L E+++++   L E   + Q          ++  D K   QDF +  +A    
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 1087 --DFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTL 1144
               F    ++L    E KA  + ++   ++RL       ++E +   +D+ N+  L   L
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-------QQELDDLVVDLDNQRQLVSNL 1453

Query: 1145 GMTMNHFFSLMQAELN----------------RFQDTKRL--LQDYYWGMESKIPVEDNK 1186
                  F  L+  E N                R ++TK L   +     +E+K  +E   
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513

Query: 1187 RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTK-----------SVLKGKM 1235
            +  +  +  L S  +   +  +  + +   +LET   + KT+              K ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1236 DNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQ- 1294
            + +++ ++  FE D +   D   +           E    L +E K+   A   +K  + 
Sbjct: 1573 EVNMQALKGQFERDLQ-ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 1295 ------MGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKI 1348
                  + A+  +K      KQ  K          E      + +EI    ++NE + K 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 1349 KEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEK---------WLGER 1399
             E  L  LQ +  A +   +    +   L E+L + +     L ++          L E 
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1400 YLNEMASTEKLTDVARYHIETSTKIQNEL 1428
               E  + E ++D  R   + + ++ NEL
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 48/220 (21%), Positives = 100/220 (45%), Gaps = 19/220 (8%)

Query: 291  KKIQKRLEEDAFAREQREKR---RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            K+ Q++ E +    EQ+  +    + LL +QL   +A+ E Y E + +   +   +QE  
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELE 928

Query: 348  IAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
              +  M  R E+E     ++  E++   +++ D ++ L+ E A  ++ +++      K K
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 408  RFHDQIAV-ERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF 466
            +  D+I V +    +  K   +  E   +I DL+T +A+      NL   K  H+     
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHE----- 1040

Query: 467  FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEE 506
                 +  +  V+      SR++L +L+++   D +D+ E
Sbjct: 1041 ----SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 64/291 (21%), Positives = 138/291 (47%), Gaps = 24/291 (8%)

Query: 153  MRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQA 212
            +R+  + QE  + + E  A L  E+ +R Q+L+ E++    +   L  + + E  A+ + 
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK- 975

Query: 213  AIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDT 272
              +Q+ K  +   +K LE + ++      +D  +++ K   L+++ + +  + +    + 
Sbjct: 976  --LQLEKVTAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERI-SDLTTNLAEEEE 1027

Query: 273  AGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREE 332
              +  T L N +  +  I +++ RL+++  +R++ EK +RKL  D    HE  + A  + 
Sbjct: 1028 KAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE--QIADLQA 1083

Query: 333  QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL- 391
            Q+    M+ +++E  +   L   R + E+  +N   ++ +  E  + D Q+ LD E A  
Sbjct: 1084 QIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141

Query: 392  --AKQAKIDFEEQF--LK---EKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A++ K D  E+   LK   E         +  +A+ E+  +V  + LD+
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 73/346 (21%), Positives = 151/346 (43%), Gaps = 39/346 (11%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E++  +R    +++ MK+    E L   +    D  L R+    Q      + DL     
Sbjct: 1536 ELEKSKRALETQMEEMKTQL--EELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDE 1592

Query: 176  EKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMA----KIQAAIIQIPKPASNRTLKALEA 231
            +  E+ ++L+ +   ++ E +  + R+Q  + A    K++  +  +   A +      EA
Sbjct: 1593 QNEEKRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 232  QKMMKK-KKEAEDVADEIKKFEALIKKD---LQAKESASKTSLDTAGQTTTDLLNTYSDD 287
             K ++K + + +D   E++  +A   +D     AKE+  K     A     DL+    D 
Sbjct: 1651 IKQLRKLQAQMKDFQRELE--DARASRDEIFATAKENEKK-----AKSLEADLMQLQEDL 1703

Query: 288  EYIKKIQKR--LEEDAFARE-----------QREKRRRKLLMDQLIAHEAQEEAYREEQL 334
               ++ +K+  LE++  A E           Q EKRR +  + QL   E +EE    E +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL-EEELEEEQGNMEAM 1762

Query: 335  INRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERR--LKDFQDALD---REA 389
             +R+ + +QQ  +++ +L   R   +     R   E+Q++E R  L + + A+    +  
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822

Query: 390  ALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A +AKI   E+ ++++    Q A +  + + +K   +  ++ D+
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 164/951 (17%), Positives = 357/951 (37%), Gaps = 139/951 (14%)

Query: 126  LRLQNMKSDTFQERLRHMIPRQTDFN--LMRITYRFQEKYKHVKEDLAHLHFEKLERFQK 183
            L+L+ + ++   ++L   I    D N  L +     +E+   +  +LA    EK +   K
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-EKAKNLTK 1034

Query: 184  LKEEQRCF------DIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKK 237
            LK +           ++K+  +R+   ++  K++       +  ++   +  E +  + K
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 238  KKEAEDVA-----DEIKKFEALIKK---------DLQAKESASKTSLDTAGQTTTDLLNT 283
            K+E    A     DEI +    +KK         DLQ    + + + + A +   DL   
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1151

Query: 284  YSDDEYIK-KIQKRLEEDAFAREQREKRR------RKLLMDQLIAHEAQEEAYREE--QL 334
              + E +K +++  L+  A  +E R KR       +K L ++  +HEAQ +  R++  Q 
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 335  INRLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQD 383
            +  L  Q +Q +R    L             +  E  VL Q +  +E +H++++L+    
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--QEVEHKKKKLEAQVQ 1269

Query: 384  ALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKV 443
             L  + +  ++A+ +     L +K    Q  VE       +      ++   +  LS+++
Sbjct: 1270 ELQSKCSDGERARAE-----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324

Query: 444  ADYRMLTNNLIPYKL---------------MHDWKELFFNAKPIYEQ-ASVKTLPANPSR 487
             D + L       KL               + D  +    AK   E+  S   +  + S+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

Query: 488  EQLTE----LEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA--- 540
            ++L +    +E  +       +E +N+  ++       D L  + N +   +   +    
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 541  -EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQ 599
             ++ L    E    +      +   +    + +     +  ++   + LS+   ++EA++
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 600  AFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLS 659
            A  + E+ +++L  +  D   +   + + + E +  +                E +T L 
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QMEEMKTQLE 1556

Query: 660  ANADKTPKAEEVK----SSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVL------LVD-- 707
               D+    E+ K     +   LK      L A+ EQ  +K + +   L      L D  
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 708  -----------IIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKA 756
                        +   + ++ +  D  + G    + Q + L+  +    R   E+E  +A
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR---ELEDARA 1673

Query: 757  QKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMN---DIIAEELSYKTAHEDIS 813
             +  +    AT+KE    + + +  ++    D ++  R     D+  EEL+     E+++
Sbjct: 1674 SRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-----EELA 1725

Query: 814  QRVAAENQDKDGDQNLR---DQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESL 870
              ++  N  +D  + L     Q++  +     N   +     +      +++ E+  E  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 871  CEKVKEILTTEIAKKKNKVEKKLEEKE--AEKKAAASLAELPLPTPPPAPPPEPEKEKEI 928
              +  E    ++ ++  ++  KL E E   + K  +++A L           E + E+E 
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----EAKIAQLEEQVEQEA 1841

Query: 929  HQSHVASKTPTAKGKP--------QSEAPHGKQESLQEGKGKKGETALKRK 971
             +   A+K+   K K         + E    +Q   Q  KG      LKR+
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 84/449 (18%), Positives = 164/449 (36%), Gaps = 71/449 (15%)

Query: 1042 IKTVLRHLREDQHTVLAYLYEIRTSFQEF--------LKRPDHK---QDFVAQWQA---- 1086
            + T LR L E+++++   L E   + Q          ++  D K   QDF +  +A    
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 1087 --DFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTL 1144
               F    ++L    E KA  + ++   ++RL       ++E +   +D+ N+  L   L
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-------QQELDDLVVDLDNQRQLVSNL 1453

Query: 1145 GMTMNHFFSLMQAELN----------------RFQDTKRL--LQDYYWGMESKIPVEDNK 1186
                  F  L+  E N                R ++TK L   +     +E+K  +E   
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513

Query: 1187 RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTK-----------SVLKGKM 1235
            +  +  +  L S  +   +  +  + +   +LET   + KT+              K ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1236 DNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQ- 1294
            + +++ ++  FE D +   D   +           E    L +E K+   A   +K  + 
Sbjct: 1573 EVNMQALKGQFERDLQ-ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 1295 ------MGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKI 1348
                  + A+  +K      KQ  K          E      + +EI    ++NE + K 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 1349 KEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEK---------WLGER 1399
             E  L  LQ +  A +   +    +   L E+L + +     L ++          L E 
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1400 YLNEMASTEKLTDVARYHIETSTKIQNEL 1428
               E  + E ++D  R   + + ++ NEL
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 48/220 (21%), Positives = 100/220 (45%), Gaps = 19/220 (8%)

Query: 291  KKIQKRLEEDAFAREQREKR---RRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERR 347
            K+ Q++ E +    EQ+  +    + LL +QL   +A+ E Y E + +   +   +QE  
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAEEMRVRLAAKKQELE 921

Query: 348  IAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
              +  M  R E+E     ++  E++   +++ D ++ L+ E A  ++ +++      K K
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 408  RFHDQIAV-ERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELF 466
            +  D+I V +    +  K   +  E   +I DL+T +A+      NL   K  H+     
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHE----- 1033

Query: 467  FNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEE 506
                 +  +  V+      SR++L +L+++   D +D+ E
Sbjct: 1034 ----SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 64/291 (21%), Positives = 138/291 (47%), Gaps = 24/291 (8%)

Query: 153  MRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQA 212
            +R+  + QE  + + E  A L  E+ +R Q+L+ E++    +   L  + + E  A+ + 
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK- 968

Query: 213  AIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDT 272
              +Q+ K  +   +K LE + ++      +D  +++ K   L+++ + +  + +    + 
Sbjct: 969  --LQLEKVTAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERI-SDLTTNLAEEEE 1020

Query: 273  AGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREE 332
              +  T L N +  +  I +++ RL+++  +R++ EK +RKL  D    HE  + A  + 
Sbjct: 1021 KAKNLTKLKNKH--ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE--QIADLQA 1076

Query: 333  QLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL- 391
            Q+    M+ +++E  +   L   R + E+  +N   ++ +  E  + D Q+ LD E A  
Sbjct: 1077 QIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134

Query: 392  --AKQAKIDFEEQF--LK---EKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A++ K D  E+   LK   E         +  +A+ E+  +V  + LD+
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 73/346 (21%), Positives = 151/346 (43%), Gaps = 39/346 (11%)

Query: 116  EMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHF 175
            E++  +R    +++ MK+    E L   +    D  L R+    Q      + DL     
Sbjct: 1529 ELEKSKRALETQMEEMKTQL--EELEDELQATEDAKL-RLEVNMQALKGQFERDLQARDE 1585

Query: 176  EKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMA----KIQAAIIQIPKPASNRTLKALEA 231
            +  E+ ++L+ +   ++ E +  + R+Q  + A    K++  +  +   A +      EA
Sbjct: 1586 QNEEKRRQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 232  QKMMKK-KKEAEDVADEIKKFEALIKKD---LQAKESASKTSLDTAGQTTTDLLNTYSDD 287
             K ++K + + +D   E++  +A   +D     AKE+  K     A     DL+    D 
Sbjct: 1644 IKQLRKLQAQMKDFQRELE--DARASRDEIFATAKENEKK-----AKSLEADLMQLQEDL 1696

Query: 288  EYIKKIQKR--LEEDAFARE-----------QREKRRRKLLMDQLIAHEAQEEAYREEQL 334
               ++ +K+  LE++  A E           Q EKRR +  + QL   E +EE    E +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL-EEELEEEQGNMEAM 1755

Query: 335  INRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERR--LKDFQDALD---REA 389
             +R+ + +QQ  +++ +L   R   +     R   E+Q++E R  L + + A+    +  
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815

Query: 390  ALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQ 435
              A +AKI   E+ ++++    Q A +  + + +K   +  ++ D+
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 164/951 (17%), Positives = 357/951 (37%), Gaps = 139/951 (14%)

Query: 126  LRLQNMKSDTFQERLRHMIPRQTDFN--LMRITYRFQEKYKHVKEDLAHLHFEKLERFQK 183
            L+L+ + ++   ++L   I    D N  L +     +E+   +  +LA    EK +   K
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-EKAKNLTK 1027

Query: 184  LKEEQRCF------DIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKK 237
            LK +           ++K+  +R+   ++  K++       +  ++   +  E +  + K
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 238  KKEAEDVA-----DEIKKFEALIKK---------DLQAKESASKTSLDTAGQTTTDLLNT 283
            K+E    A     DEI +    +KK         DLQ    + + + + A +   DL   
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL--- 1144

Query: 284  YSDDEYIK-KIQKRLEEDAFAREQREKRR------RKLLMDQLIAHEAQEEAYREE--QL 334
              + E +K +++  L+  A  +E R KR       +K L ++  +HEAQ +  R++  Q 
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 335  INRLMRQSQQERRIAVQL-----------MHVRHEKEVLWQNRIFREKQHEERRLKDFQD 383
            +  L  Q +Q +R    L             +  E  VL Q +  +E +H++++L+    
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--QEVEHKKKKLEAQVQ 1262

Query: 384  ALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKV 443
             L  + +  ++A+ +     L +K    Q  VE       +      ++   +  LS+++
Sbjct: 1263 ELQSKCSDGERARAE-----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317

Query: 444  ADYRMLTNNLIPYKL---------------MHDWKELFFNAKPIYEQ-ASVKTLPANPSR 487
             D + L       KL               + D  +    AK   E+  S   +  + S+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377

Query: 488  EQLTE----LEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLA--- 540
            ++L +    +E  +       +E +N+  ++       D L  + N +   +   +    
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 541  -EKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQ 599
             ++ L    E    +      +   +    + +     +  ++   + LS+   ++EA++
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 600  AFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLS 659
            A  + E+ +++L  +  D   +   + + + E +  +                E +T L 
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--------QMEEMKTQLE 1549

Query: 660  ANADKTPKAEEVK----SSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVL------LVD-- 707
               D+    E+ K     +   LK      L A+ EQ  +K + +   L      L D  
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 708  -----------IIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKA 756
                        +   + ++ +  D  + G    + Q + L+  +    R   E+E  +A
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR---ELEDARA 1666

Query: 757  QKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMN---DIIAEELSYKTAHEDIS 813
             +  +    AT+KE    + + +  ++    D ++  R     D+  EEL+     E+++
Sbjct: 1667 SRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA-----EELA 1718

Query: 814  QRVAAENQDKDGDQNLR---DQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESL 870
              ++  N  +D  + L     Q++  +     N   +     +      +++ E+  E  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 871  CEKVKEILTTEIAKKKNKVEKKLEEKE--AEKKAAASLAELPLPTPPPAPPPEPEKEKEI 928
              +  E    ++ ++  ++  KL E E   + K  +++A L           E + E+E 
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL----EAKIAQLEEQVEQEA 1834

Query: 929  HQSHVASKTPTAKGKP--------QSEAPHGKQESLQEGKGKKGETALKRK 971
             +   A+K+   K K         + E    +Q   Q  KG      LKR+
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 84/449 (18%), Positives = 164/449 (36%), Gaps = 71/449 (15%)

Query: 1042 IKTVLRHLREDQHTVLAYLYEIRTSFQEF--------LKRPDHK---QDFVAQWQA---- 1086
            + T LR L E+++++   L E   + Q          ++  D K   QDF +  +A    
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 1087 --DFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTL 1144
               F    ++L    E KA  + ++   ++RL       ++E +   +D+ N+  L   L
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL-------QQELDDLVVDLDNQRQLVSNL 1446

Query: 1145 GMTMNHFFSLMQAELN----------------RFQDTKRL--LQDYYWGMESKIPVEDNK 1186
                  F  L+  E N                R ++TK L   +     +E+K  +E   
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506

Query: 1187 RFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTK-----------SVLKGKM 1235
            +  +  +  L S  +   +  +  + +   +LET   + KT+              K ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGK-NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1236 DNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQ- 1294
            + +++ ++  FE D +   D   +           E    L +E K+   A   +K  + 
Sbjct: 1566 EVNMQALKGQFERDLQ-ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 1295 ------MGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKI 1348
                  + A+  +K      KQ  K          E      + +EI    ++NE + K 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 1349 KEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEK---------WLGER 1399
             E  L  LQ +  A +   +    +   L E+L + +     L ++          L E 
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1400 YLNEMASTEKLTDVARYHIETSTKIQNEL 1428
               E  + E ++D  R   + + ++ NEL
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 62/278 (22%), Positives = 119/278 (42%), Gaps = 40/278 (14%)

Query: 160 QEKYKHVKEDLAHLHFEKLERFQKLKE-----EQRCFDIEKQYLNRRRQNEIMAKIQAAI 214
           +E    ++ DL  +  EK E  +KL E     E     +E+ +   +RQ E++A+     
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE- 730

Query: 215 IQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEA---LIKKDLQAKESASKTSLD 271
               K A  R   ALE  ++   +++ +D+A++++   +   L++  L   +  +     
Sbjct: 731 ----KEALVREKAALEV-RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785

Query: 272 TAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYRE 331
           T GQ    +       E I               Q E R  KL +D       + +A +E
Sbjct: 786 TKGQLEVQIQTVTQAKEVI---------------QGEVRCLKLELDT-----ERSQAEQE 825

Query: 332 EQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAAL 391
                R + Q++QE + A++     HEKEV   N++ REK  +ER     Q  L +    
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEV---NQL-REKWEKERSW--HQQELAKALES 879

Query: 392 AKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVC 429
            ++ K++ E +  +++   + I  +R + R +   ++C
Sbjct: 880 LEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALC 917



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 65/321 (20%), Positives = 140/321 (43%), Gaps = 48/321 (14%)

Query: 152  LMRITYRFQEKYKHVKEDLAHLHF----------EKLERFQKLKEEQRCFDI---EKQYL 198
            L  +T   +E+ + ++   + +H           E  ER Q++K ++   +    +K++L
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHL 1649

Query: 199  NR---RRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALI 255
             +   RR  E+M  +Q   IQ+ +    R  K LE + + + K    +   E+     L+
Sbjct: 1650 TQDLERRDQELM--LQKERIQVLEDQRTRQTKILE-EDLEQIKLSLRERGRELTTQRQLM 1706

Query: 256  KKDLQAKESASKTSLDTAGQTTTDLLNTYSD----DEYIKKIQK---RLEEDAFAREQR- 307
            ++  +  +  SK    +       L +   +     E+I ++Q+   +LE+      ++ 
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766

Query: 308  -------EKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKE 360
                    +R +++++ Q    EA+E+   +EQ +   + ++Q+       L     E E
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA------LAQRDQELE 1820

Query: 361  VLWQNRIFREKQHEERRLKD----FQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVE 416
             L Q +  ++ Q +E R+K+     Q AL++     K+   + ++   + +R  +++AVE
Sbjct: 1821 ALQQEQ--QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878

Query: 417  --RAQARYEKHYSVCAEILDQ 435
              R QA  E    + AE  +Q
Sbjct: 1879 GRRVQALEEVLGDLRAESREQ 1899



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 70/345 (20%), Positives = 138/345 (40%), Gaps = 56/345 (16%)

Query: 87   TEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQER--LRHM- 143
            T +  +  + L Q+ ++L+++      G E+ T ++L   R +  K  +  +R  L HM 
Sbjct: 1675 TRQTKILEEDLEQIKLSLRER------GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728

Query: 144  -IPRQTDFNL---MRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKE-EQRCFDIEKQYL 198
             I R  +  +       +  QE    +++ L  LH +  E    L + EQ    +++Q  
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788

Query: 199  NRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKD 258
              R Q E+  K Q+   Q+ +       +  E + + +++++A+   + +K+        
Sbjct: 1789 EAREQGEL--KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE-------- 1838

Query: 259  LQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAR-------------- 304
               K  A + +L+ A  T  +      D    K+  +RLEE+                  
Sbjct: 1839 ---KADALQGALEQAHMTLKERHGELQDH---KEQARRLEEELAVEGRRVQALEEVLGDL 1892

Query: 305  --EQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVL 362
              E RE+ +  L + Q  A +AQE       L         Q+  +  Q +    ++E+ 
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRAL---------QDSWLQAQAVLKERDQELE 1943

Query: 363  WQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEK 407
                  +  +H+E   +   +AL +EA     A +  +EQ L E+
Sbjct: 1944 ALRAESQSSRHQEEAARARAEAL-QEALGKAHAALQGKEQHLLEQ 1987



 Score = 35.8 bits (81), Expect = 0.39
 Identities = 77/367 (20%), Positives = 145/367 (39%), Gaps = 57/367 (15%)

Query: 1089 NSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTM 1148
            + L  DLW  ++T+  L  +V  L +RL D  +A K +   E  D+  +           
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTD-TEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304

Query: 1149 NHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRI 1208
                + +++EL    +T   LQ      E +      +R     L+Q  +K+N  +Q+  
Sbjct: 1305 EGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER----ELLQA-AKENLTAQVE- 1358

Query: 1209 PLVPRISISLETVTPKPKTKSVLKGKMDNSLENVES-------NFEADEKLVMDTWQQAS 1261
                     L+    + + ++   G ++  L    S         E++ +      +Q  
Sbjct: 1359 --------HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410

Query: 1262 LAVSHMVA-----AEIHQRLMEEEKENQPAD------PKEKSPQMGANKKVKKEPPKKKQ 1310
            L V+   A     A + Q L E E+E +          K++  Q  A + +  +  K+ Q
Sbjct: 1411 LKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470

Query: 1311 E--------DKKPKGKSP----PMA---EATPVIVTTEEIAEIKRKNELRVKIKEEHLAA 1355
            E         +  K +S     PMA       + V  E+I E+++  E +  + E  L  
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLE 1530

Query: 1356 LQFEE--IATQ------FRLELIKTKALAL-LEDLVTKVVDVYKLMEKWLGERYLNEMAS 1406
            L+ ++  I +Q       + +L+  + LAL LE+   K+    KL+++  G+R    +A 
Sbjct: 1531 LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590

Query: 1407 TEKLTDV 1413
            T    D+
Sbjct: 1591 THLTLDL 1597



 Score = 35.4 bits (80), Expect = 0.51
 Identities = 58/304 (19%), Positives = 121/304 (39%), Gaps = 27/304 (8%)

Query: 65   RLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLT 124
            ++E  + L   Q +         E+   A   L Q+ +  +K++ S L  + +QT + L 
Sbjct: 884  KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL-LQTQKELA 942

Query: 125  NL--RLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQ 182
            +   +L+ ++ D   ++L+     Q    +++   + QE  + +KE  A  H + L   Q
Sbjct: 943  DASQQLERLRQDMKVQKLKE----QETTGILQT--QLQEAQRELKE-AARQHRDDLAALQ 995

Query: 183  KLKEE--QRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKE 240
            +      Q   D++KQ  + + Q       Q  + Q             E Q+ +++ +E
Sbjct: 996  EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ-------------EVQEKLRETQE 1042

Query: 241  AEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRL--E 298
               +  E+++ +A +   L  KE       +       +L     D +  +  QK L  +
Sbjct: 1043 YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQ 1102

Query: 299  EDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHE 358
             +   +E +EK    L  +  +  E +     E+QL   L  Q  +  ++ ++L     +
Sbjct: 1103 MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ 1162

Query: 359  KEVL 362
             E L
Sbjct: 1163 LEAL 1166


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
            sapiens]
          Length = 916

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 55/206 (26%), Positives = 80/206 (38%), Gaps = 40/206 (19%)

Query: 855  ENILIKINAEIDKESLCEKVKEILTTEIA-----KKKNKVEKKLEEKEAEKKAAASLAEL 909
            E I+ +   E D++S  E+    +T E+A     +KK   E+K EE EAE++  A+    
Sbjct: 454  EEIIEETKVE-DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 512

Query: 910  PLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQES--LQEGKGKKGETA 967
               T P     E EKE+E  Q     +   AK     E    K+ S   +EG+ ++GET 
Sbjct: 513  VKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572

Query: 968  LKRKG---------------------------SPKGKSSGGKVPVKKSPADSTDTSPVAI 1000
             + +G                           +   K    K PV KSP +    SPV  
Sbjct: 573  AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 632

Query: 1001 VP-----QPPKPGSEEWVYVNEPVPE 1021
             P     + P P S        PVP+
Sbjct: 633  SPVEEKGKSPVPKSPVEEKGKSPVPK 658



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 43/157 (27%), Positives = 65/157 (41%), Gaps = 23/157 (14%)

Query: 883  AKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKG 942
            AK++ KVE+K EE   +++  A            A   +PEK K        S  P +  
Sbjct: 582  AKEEKKVEEKSEEVATKEELVAD-----------AKVEKPEKAK--------SPVPKSPV 622

Query: 943  KPQSEAPHGKQESLQEGKGKKGETALKRKG-SPKGKS---SGGKVPVKKSPADSTDTSPV 998
            + + ++P  K    ++GK    ++ ++ KG SP  KS     GK PV KSP +    SPV
Sbjct: 623  EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV 682

Query: 999  AIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIE 1035
               P        E     +   EE  +   P  E +E
Sbjct: 683  PKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 57/231 (24%), Positives = 93/231 (40%), Gaps = 24/231 (10%)

Query: 788  DTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLL 847
            + S M      I EEL+     E   ++ AAE ++++ +    +++  +        P +
Sbjct: 465  EKSEMEEALTAITEELAVSMKEE---KKEAAEEKEEEPEAE-EEEVAAKKSPVKATAPEV 520

Query: 848  EQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLA 907
            ++   E E    +   E + E       E   +E      K E + EE E E +A    A
Sbjct: 521  KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEA 580

Query: 908  ELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKG----KPQ-SEAPHGKQESLQEGKGK 962
            E            + EK+ E     VA+K          KP+ +++P  K    ++GK  
Sbjct: 581  EA-----------KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 629

Query: 963  KGETALKRKG-SPKGKS---SGGKVPVKKSPADSTDTSPVAIVPQPPKPGS 1009
              ++ ++ KG SP  KS     GK PV KSP +    SPV+  P   K  S
Sbjct: 630  VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 680



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 42/168 (25%), Positives = 74/168 (44%), Gaps = 25/168 (14%)

Query: 1179 KIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNS 1238
            K PVE+  + + +P   ++ K  S        VP+  +  +  +P PK+    KGK   S
Sbjct: 619  KSPVEEKGK-SPVPKSPVEEKGKSP-------VPKSPVEEKGKSPVPKSPVEEKGKSPVS 670

Query: 1239 LENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPAD-PKEKSPQMGA 1297
               VE   +A   +     ++A         AE+ +   +EE+E +  + PKE+      
Sbjct: 671  KSPVEE--KAKSPVPKSPVEEAKSK------AEVGKGEQKEEEEKEVKEAPKEE------ 716

Query: 1298 NKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELR 1345
              KV+K+  K K   +K K +SP   EA   +VT  +  ++  + E +
Sbjct: 717  --KVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 762



 Score = 33.5 bits (75), Expect = 1.9
 Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 10/128 (7%)

Query: 860 KINAEIDKESLCEKVKEILT---TEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPP 916
           K  + + K  + EK K  +     E AK K +V K  +++E EK+   +  E  +     
Sbjct: 664 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEE 723

Query: 917 APPPEPEKEK---EIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGS 973
            P   PEK+K    + +  VA      K    S   H ++E+ +EGK  + E   ++ G 
Sbjct: 724 KPKDVPEKKKAESPVKEEAVAEVVTITK----SVKVHLEKETKEEGKPLQQEKEKEKAGG 779

Query: 974 PKGKSSGG 981
             G    G
Sbjct: 780 EGGSEEEG 787



 Score = 32.7 bits (73), Expect = 3.3
 Identities = 29/105 (27%), Positives = 45/105 (42%), Gaps = 5/105 (4%)

Query: 881 EIAKKKNKVEKKLEEKEAEKKAAASLAE-LPLPTPPPAPPPEPEKEKEIHQSHVASKTPT 939
           E+ K + K E++ E KEA K+      E  P   P       P KE+ +  + V + T +
Sbjct: 695 EVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV--AEVVTITKS 752

Query: 940 AKGKPQSEAPHGKQESLQEGKGKK--GETALKRKGSPKGKSSGGK 982
            K   + E     +   QE + +K  GE   + +GS KG     K
Sbjct: 753 VKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 797



 Score = 31.6 bits (70), Expect = 7.4
 Identities = 57/297 (19%), Positives = 117/297 (39%), Gaps = 21/297 (7%)

Query: 1081 VAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESW- 1139
            +A+++    S   +L     TK  L ++++D+ +R      + ++  +Q   ++    W 
Sbjct: 317  IAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWE 376

Query: 1140 -------LQDTLGMTMN------HFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNK 1186
                    QD L + M        +  L++ E  RF      +    +     I +    
Sbjct: 377  MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 436

Query: 1187 RFTRI--PLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSV-LKGKMDNSLENVE 1243
            +  ++  P +++  K   E      +    S   E +T   +  +V +K +   + E  E
Sbjct: 437  QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496

Query: 1244 SNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKK 1303
               EA+E+ V             +   E  +   E ++E +  D   KS Q       +K
Sbjct: 497  EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS-EK 555

Query: 1304 EPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEE 1360
            E   +K+E ++ +G++   AEA       +E  +++ K+E  V  KEE +A  + E+
Sbjct: 556  EGSSEKEEGEQEEGETE--AEAEGEEAEAKEEKKVEEKSE-EVATKEELVADAKVEK 609



 Score = 31.6 bits (70), Expect = 7.4
 Identities = 39/157 (24%), Positives = 57/157 (36%), Gaps = 10/157 (6%)

Query: 864  EIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPE 923
            E  KE   EK +E       K K+  EKK  E   +++A A +  +             E
Sbjct: 711  EAPKEEKVEKKEE-------KPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763

Query: 924  KEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSG-GK 982
            + K + Q     K     G  +  +  G + S +E     GE   K +   + K  G G+
Sbjct: 764  EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGR 823

Query: 983  VPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPV 1019
               K    +  D SP        K  SEE V V + V
Sbjct: 824  EEEKGVVTNGLDLSPADEKKGGDK--SEEKVVVTKTV 858



 Score = 31.2 bits (69), Expect = 9.6
 Identities = 19/64 (29%), Positives = 34/64 (53%), Gaps = 5/64 (7%)

Query: 1657 VFQQVKASIPSA---EKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPEN 1713
            V ++ K+ +P +   E  S  + G  E+  E EE   +E  K ++  EK+E+K +++PE 
Sbjct: 674  VEEKAKSPVPKSPVEEAKSKAEVGKGEQ-KEEEEKEVKEAPK-EEKVEKKEEKPKDVPEK 731

Query: 1714 ANNE 1717
               E
Sbjct: 732  KKAE 735


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,601,972
Number of Sequences: 37866
Number of extensions: 3645421
Number of successful extensions: 31313
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 995
Number of HSP's that attempted gapping in prelim test: 21503
Number of HSP's gapped (non-prelim): 8561
length of query: 1822
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1705
effective length of database: 13,817,196
effective search space: 23558319180
effective search space used: 23558319180
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.