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Search of human proteins with 14249340
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249340 phospholipase C, delta 4 [Homo sapiens]
(762 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 1545 0.0
gi|19115964 phospholipase C delta 3 [Homo sapiens] 712 0.0
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 689 0.0
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 689 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 509 e-144
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 509 e-144
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 506 e-143
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 480 e-135
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 480 e-135
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 360 3e-99
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 360 3e-99
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 345 7e-95
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 342 6e-94
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 342 6e-94
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 338 1e-92
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 337 3e-92
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 337 3e-92
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 337 3e-92
gi|11386139 phospholipase C beta 3 [Homo sapiens] 325 1e-88
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 227 4e-59
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 227 4e-59
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 219 1e-56
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 177 2e-44
gi|38570146 synaptotagmin VII [Homo sapiens] 50 6e-06
gi|92859638 synaptotagmin V [Homo sapiens] 48 4e-05
gi|216548478 synaptotagmin XI [Homo sapiens] 46 1e-04
gi|211059429 synaptotagmin II [Homo sapiens] 45 2e-04
gi|31543670 synaptotagmin II [Homo sapiens] 45 2e-04
gi|209447073 synaptotagmin I [Homo sapiens] 45 3e-04
gi|5032139 synaptotagmin I [Homo sapiens] 45 3e-04
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 1545 bits (4001), Expect = 0.0
Identities = 762/762 (100%), Positives = 762/762 (100%)
Query: 1 MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPS 60
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPS
Sbjct: 1 MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPS 60
Query: 61 FSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQ 120
FSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQ
Sbjct: 61 FSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQ 120
Query: 121 LLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ 180
LLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ
Sbjct: 121 LLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQ 180
Query: 181 AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDC 240
AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDC
Sbjct: 181 AADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDC 240
Query: 241 TSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYF 300
TSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYF
Sbjct: 241 TSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYF 300
Query: 301 ICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILF 360
ICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILF
Sbjct: 301 ICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILF 360
Query: 361 KDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQL 420
KDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQL
Sbjct: 361 KDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQL 420
Query: 421 PSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480
PSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD
Sbjct: 421 PSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480
Query: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540
KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV
Sbjct: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540
Query: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600
QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG
Sbjct: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600
Query: 601 YVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIF 660
YVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIF
Sbjct: 601 YVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIF 660
Query: 661 GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL
Sbjct: 661 GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
Query: 721 PWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES 762
PWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES
Sbjct: 721 PWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES 762
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 712 bits (1838), Expect = 0.0
Identities = 369/747 (49%), Positives = 494/747 (66%), Gaps = 16/747 (2%)
Query: 9 LTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQA-RGSAKPSFSISDVE 67
LT D+D+ M G +RK+RS++W K R +RLQ DG++VW R+ R ++ F + +E
Sbjct: 56 LTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIE 115
Query: 68 TIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVT 127
+R GH SE LR + TI F GRR NLDL A + EEAQ W+RGL L +
Sbjct: 116 AVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARLD 175
Query: 128 SMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS 187
+M +ERLD W+ + R D NQD KMSF+E++ LL ++NV+M+ YA+ LF+ D S +
Sbjct: 176 AMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNN 235
Query: 188 GTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALE 247
LEG E +F + L KR E++E+F +S + + L+ E L+FL E+Q E T A +
Sbjct: 236 DRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFL-EDQGEEGATLARAQQ 294
Query: 248 LIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNT 307
LI YE +++ K ++++DGF+ YL S +G + ++QDM QPL HYFI SSHNT
Sbjct: 295 LIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNT 354
Query: 308 YLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATV 367
YL Q+ G SS E Y+RA +GCRCVE+D W+GP GEPV+YHGHTLTS+ILF+DVV V
Sbjct: 355 YLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAV 414
Query: 368 AQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELR 427
+AF S YPVILSLE HC EQQ MARHL ILG+ L++ LD P +LPSPE+L+
Sbjct: 415 RDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLK 474
Query: 428 RKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKP 487
++LVKGKKL E+ A + EE E + E +E+ ++ +++ +K
Sbjct: 475 GRVLVKGKKLPAARS---EDGRALSDREEE--------EEDDEEEEEEVEAAAQRRLAKQ 523
Query: 488 ILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQL 547
I P LS+L +Y + R+ + ++SS SE KAK+LI+EAGN FV+HN QL
Sbjct: 524 I-SPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQL 582
Query: 548 SRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDF 607
+RVYP GLR +S+NY+PQE+WN+GCQ+VA+N QT G EMD+ G F NG CGYVLKP
Sbjct: 583 TRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPAC 642
Query: 608 LRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTA 667
LR S+F PE P P TL IQV++ QQLPK++ K SIVDPLV+++I GV D A
Sbjct: 643 LRQPDSTFDPEYPGPP--RTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPADCA 700
Query: 668 RQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQ 727
RQET+YV NNGFNP WGQTL F++ PELA++RFVV DYD S NDF+GQ+TLP + ++Q
Sbjct: 701 RQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQ 760
Query: 728 GYRHIHLLSKDGISLRPASIFVYICIQ 754
GYRHIHLLSKDG SL PA++F+ I IQ
Sbjct: 761 GYRHIHLLSKDGASLSPATLFIQIRIQ 787
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 689 bits (1778), Expect = 0.0
Identities = 364/756 (48%), Positives = 496/756 (65%), Gaps = 21/756 (2%)
Query: 9 LTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQA--RGSAKPSFSISDV 66
L D+DL + +G + KV+S SW++ R+++LQ D T+W + R FSI D+
Sbjct: 13 LQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDI 72
Query: 67 ETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLV 126
+ +R GH +E L A ++P ++ F+IVF +R+ LDL+A S +AQ W+ GL ++
Sbjct: 73 QEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHS 132
Query: 127 TSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQ 186
SMD +++L W+ ++ DKN+D KMSF+E+Q L +N+++D YA +F+ D SQ
Sbjct: 133 GSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 192
Query: 187 SGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELAL 246
+ +LE EE FYK LT+R E+ F + G+ L++ + + FLQ +Q+E LAL
Sbjct: 193 TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALAL 252
Query: 247 ELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHN 306
LI+RYEPS++ K + ++ DGFL YL S DG F+ A +YQDM QPL+HY + SSHN
Sbjct: 253 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 312
Query: 307 TYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVAT 366
TYL+ DQL G SS E YIRAL +GCRC+E+D WDGP+ EP++YHG+T TS+ILF DV+
Sbjct: 313 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRA 372
Query: 367 VAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEEL 426
+ YAF+ S YPVILSLE HC+ EQQ+ MARHL ILG LL+ LDGV LPSPE+L
Sbjct: 373 IRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGV-TNSLPSPEQL 431
Query: 427 RRKILVKGKKLTLEEDLEYEEEEAEPEL----EESELALESQFETEPEPQEQNLQNKDKK 482
+ KIL+KGKKL L E PE +E E A E E E +Q+K K+
Sbjct: 432 KGKILLKGKKL---GGLLPPGGEGGPEATVVSDEDEAA-----EMEDEAVRSRVQHKPKE 483
Query: 483 KKSKPILCPALSSLVIYLKSVSFRSFTH-SKEHYHFYEISSFSETKAKRLIKEAGNEFVQ 541
K + L LS +VIY KSV F F+ FYE++SFSE +A RL++E+GN FV+
Sbjct: 484 DKLR--LAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 541
Query: 542 HNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGY 601
HN LSR+YP+G RTDSSNY+P E+WN GCQ+VA+N QT G EMD+ G F+ NG CGY
Sbjct: 542 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 601
Query: 602 VLKPDFLRDIQSSFHPEK-PISPFKAQTLL-IQVISGQQLPKVDKTKEGSIVDPLVKVQI 659
VLKP FLRD +F+P P+ A+ L I+VISGQQLPKV+K K SIVDP V V+I
Sbjct: 602 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEI 660
Query: 660 FGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYT 719
GV D A ++T + NNGFNP+W F V+VP+LA++RF+V DYD S+NDFIGQ T
Sbjct: 661 HGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQST 720
Query: 720 LPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
+P ++QGYRH+HL+SK+G A++FV I +Q+
Sbjct: 721 IPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 689 bits (1778), Expect = 0.0
Identities = 364/756 (48%), Positives = 496/756 (65%), Gaps = 21/756 (2%)
Query: 9 LTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQA--RGSAKPSFSISDV 66
L D+DL + +G + KV+S SW++ R+++LQ D T+W + R FSI D+
Sbjct: 34 LQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDI 93
Query: 67 ETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLV 126
+ +R GH +E L A ++P ++ F+IVF +R+ LDL+A S +AQ W+ GL ++
Sbjct: 94 QEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHS 153
Query: 127 TSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQ 186
SMD +++L W+ ++ DKN+D KMSF+E+Q L +N+++D YA +F+ D SQ
Sbjct: 154 GSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
Query: 187 SGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELAL 246
+ +LE EE FYK LT+R E+ F + G+ L++ + + FLQ +Q+E LAL
Sbjct: 214 TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALAL 273
Query: 247 ELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHN 306
LI+RYEPS++ K + ++ DGFL YL S DG F+ A +YQDM QPL+HY + SSHN
Sbjct: 274 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 333
Query: 307 TYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVAT 366
TYL+ DQL G SS E YIRAL +GCRC+E+D WDGP+ EP++YHG+T TS+ILF DV+
Sbjct: 334 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRA 393
Query: 367 VAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEEL 426
+ YAF+ S YPVILSLE HC+ EQQ+ MARHL ILG LL+ LDGV LPSPE+L
Sbjct: 394 IRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGV-TNSLPSPEQL 452
Query: 427 RRKILVKGKKLTLEEDLEYEEEEAEPEL----EESELALESQFETEPEPQEQNLQNKDKK 482
+ KIL+KGKKL L E PE +E E A E E E +Q+K K+
Sbjct: 453 KGKILLKGKKL---GGLLPPGGEGGPEATVVSDEDEAA-----EMEDEAVRSRVQHKPKE 504
Query: 483 KKSKPILCPALSSLVIYLKSVSFRSFTH-SKEHYHFYEISSFSETKAKRLIKEAGNEFVQ 541
K + L LS +VIY KSV F F+ FYE++SFSE +A RL++E+GN FV+
Sbjct: 505 DKLR--LAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 562
Query: 542 HNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGY 601
HN LSR+YP+G RTDSSNY+P E+WN GCQ+VA+N QT G EMD+ G F+ NG CGY
Sbjct: 563 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 622
Query: 602 VLKPDFLRDIQSSFHPEK-PISPFKAQTLL-IQVISGQQLPKVDKTKEGSIVDPLVKVQI 659
VLKP FLRD +F+P P+ A+ L I+VISGQQLPKV+K K SIVDP V V+I
Sbjct: 623 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEI 681
Query: 660 FGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYT 719
GV D A ++T + NNGFNP+W F V+VP+LA++RF+V DYD S+NDFIGQ T
Sbjct: 682 HGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQST 741
Query: 720 LPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
+P ++QGYRH+HL+SK+G A++FV I +Q+
Sbjct: 742 IPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 509 bits (1312), Expect = e-144
Identities = 294/756 (38%), Positives = 436/756 (57%), Gaps = 38/756 (5%)
Query: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
M EG ++KVRS S RYF L D ++ + S K I ++ +R G ++++
Sbjct: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202
Query: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
RS +++++ + F++++ +LDL+ANS + A IW+ GL+ L+ D++ S
Sbjct: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
Query: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
R W+S F D + G ++ + + +N + E F +
Sbjct: 263 SQDNMRTS-WVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 321
Query: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
+ EEF++ + L R E+ L FS++ + L + + FL+ EQ E++
Sbjct: 322 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 381
Query: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
LE+I +YEPS G+ + LS+DGF +YL S D IF+P + QDM QPL+HYFI SSH
Sbjct: 382 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 441
Query: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
NTYL+ DQ G S + GYIRALK GCR VE+DVWDGP EPV+Y GHT+TS+I+F+ V+
Sbjct: 442 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 501
Query: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425
+ +YAF S+YP+IL LE HCS +QQ+ M +H+ ++LG++L TT V + LPSP+
Sbjct: 502 IINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLY-TTSPNVEESYLPSPDV 560
Query: 426 LRRKILVKGKKLT-----LEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480
L+ KIL+K KKL+ +E D+ E+E A E ++N++ +
Sbjct: 561 LKGKILIKAKKLSSNCSGVEGDVTDEDEGA---------------EMSQRMGKENMEQPN 605
Query: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540
+ LC LS LV KSV F+ F S + ++E+ SF+E A + E +FV
Sbjct: 606 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665
Query: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600
+N L+RV+PS +R DSSN NPQ+ W GCQ+VAMN QT GL MD+ G FRQNG CG
Sbjct: 666 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725
Query: 601 YVLKPDFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKV 657
YVL+P +R+ S F + + + Q L I++ISGQ PK + +G +VDP V V
Sbjct: 726 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785
Query: 658 QIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQ 717
+I G+ D A Q T V NG P + ++ F++ +PELAM+RFVV+D D+ ++FIGQ
Sbjct: 786 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQ 844
Query: 718 YTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
YT+P+ C+Q GYRH+ L S G L AS+FV++ I
Sbjct: 845 YTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 509 bits (1312), Expect = e-144
Identities = 294/756 (38%), Positives = 436/756 (57%), Gaps = 38/756 (5%)
Query: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
M EG ++KVRS S RYF L D ++ + S K I ++ +R G ++++
Sbjct: 17 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 76
Query: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
RS +++++ + F++++ +LDL+ANS + A IW+ GL+ L+ D++ S
Sbjct: 77 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 136
Query: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
R W+S F D + G ++ + + +N + E F +
Sbjct: 137 SQDNMRTS-WVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 195
Query: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
+ EEF++ + L R E+ L FS++ + L + + FL+ EQ E++
Sbjct: 196 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 255
Query: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
LE+I +YEPS G+ + LS+DGF +YL S D IF+P + QDM QPL+HYFI SSH
Sbjct: 256 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 315
Query: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
NTYL+ DQ G S + GYIRALK GCR VE+DVWDGP EPV+Y GHT+TS+I+F+ V+
Sbjct: 316 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 375
Query: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425
+ +YAF S+YP+IL LE HCS +QQ+ M +H+ ++LG++L TT V + LPSP+
Sbjct: 376 IINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLY-TTSPNVEESYLPSPDV 434
Query: 426 LRRKILVKGKKLT-----LEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480
L+ KIL+K KKL+ +E D+ E+E A E ++N++ +
Sbjct: 435 LKGKILIKAKKLSSNCSGVEGDVTDEDEGA---------------EMSQRMGKENMEQPN 479
Query: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540
+ LC LS LV KSV F+ F S + ++E+ SF+E A + E +FV
Sbjct: 480 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 539
Query: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600
+N L+RV+PS +R DSSN NPQ+ W GCQ+VAMN QT GL MD+ G FRQNG CG
Sbjct: 540 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 599
Query: 601 YVLKPDFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKV 657
YVL+P +R+ S F + + + Q L I++ISGQ PK + +G +VDP V V
Sbjct: 600 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 659
Query: 658 QIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQ 717
+I G+ D A Q T V NG P + ++ F++ +PELAM+RFVV+D D+ ++FIGQ
Sbjct: 660 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQ 718
Query: 718 YTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
YT+P+ C+Q GYRH+ L S G L AS+FV++ I
Sbjct: 719 YTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 506 bits (1303), Expect = e-143
Identities = 268/606 (44%), Positives = 375/606 (61%), Gaps = 14/606 (2%)
Query: 147 DKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRA 206
D + GK++ ++ QRLL +++ + +F+ D + G + EEF Y+ +T R
Sbjct: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
Query: 207 EVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSM 266
E+ E+F ++S + + L FL +EQ + + +A E+I +YEP + + H +S+
Sbjct: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
Query: 267 DGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRA 326
+GF Y+ S++ +F C +YQDMT PLN YFI SSHNTYLV DQL G S + GY+ A
Sbjct: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
Query: 327 LKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETH 386
L +GCRC+E+D WDG EPVVYHG+TLTS++LFK V+ + +YAF TSDYPV+LSLE H
Sbjct: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
Query: 387 CSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKL-TLEEDLEY 445
CS QQ+ MA +L GE LLS LD P LPSPE L+ KILVK KK+ TL+E E
Sbjct: 252 CSTAQQEVMADNLQATFGESLLSDMLDD-FPDTLPSPEALKFKILVKNKKIGTLKETHER 310
Query: 446 EEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSF 505
+ + + ++ E ++ + + KKK K + ALS LVIY K+ F
Sbjct: 311 KGSDKRGDNQDKETGVK---------KLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKF 361
Query: 506 RSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQ 565
+SF HS+ + F E +S ET+A++L K +EF+ H ++R+YP R DSSN+NPQ
Sbjct: 362 KSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQ 421
Query: 566 ELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFK 625
E WN GCQMVA+N QT GL MD+ +G F NGG GY+LKP FLR+ +S F+P I
Sbjct: 422 EFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSN-IKEGM 480
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQ 685
TL I++ISG QLP + D LV +++FGV D +Q+T ++ N F+P W +
Sbjct: 481 PITLTIRLISGIQLPLTHSSSNKG--DSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNE 538
Query: 686 TLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPA 745
T F + VPELA++RFVV + N+F+GQYTLP CM +GYR I L S+ G SL PA
Sbjct: 539 TFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPA 598
Query: 746 SIFVYI 751
S+FVY+
Sbjct: 599 SLFVYV 604
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 480 bits (1236), Expect = e-135
Identities = 288/753 (38%), Positives = 426/753 (56%), Gaps = 37/753 (4%)
Query: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
MQ G ++KVR S R+F L D + + K IS ++ IR G ++E
Sbjct: 115 MQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTET 174
Query: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
R+ LA+++ + F+I+ +LDL+ANS + A IW+ GL+ LV D +
Sbjct: 175 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 234
Query: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
+ R WL F+ D + +G M L+ +N + + F Q +
Sbjct: 235 NQNTPRF-MWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEK 293
Query: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
+ + EEF + + L R EV L S + + L + + FL+ EQ T ++
Sbjct: 294 LTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 353
Query: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
L++I RYE S+ G+ + L++DGF YL S + DIF+P + QDMTQPL+HY+I +SH
Sbjct: 354 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 413
Query: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
NTYL+ DQ G + + GYIRALK GCR VE+DV DG EP++ + + +T+ + F+ V+
Sbjct: 414 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 473
Query: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQ--LPSP 423
+ ++AF S+YP+IL L HCS QQ+ MA+ + ++ G +L + + LP++ LPSP
Sbjct: 474 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYT---EAPLPSESYLPSP 530
Query: 424 EELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKK 483
E+L+R I+VKGKKL + D+ E E E EE+E++ + E ++
Sbjct: 531 EKLKRMIIVKGKKLPSDPDV--LEGEVTDEDEEAEMSRRMSVDYNGEQKQIR-------- 580
Query: 484 KSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHN 543
LC LS LV KSV +R F S + +++E+ SFSET+A R+ E +FV +N
Sbjct: 581 -----LCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYN 635
Query: 544 TWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVL 603
LSR+YPS +R DSSN NPQ+ WN GCQ+VAMN QT G MD+ G F QNGGCGYVL
Sbjct: 636 KKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVL 695
Query: 604 KPDFLRDIQSSFHPE-KPISP-FKAQTLLIQVISGQQLPK-VDKTKEGSIVDPLVKVQIF 660
+P +RD S F K I P L I++ISGQ PK +G ++DP V ++I
Sbjct: 696 RPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIH 755
Query: 661 GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
G+ D + Q T V+ N NP + +T F+V +PELAM+RFVV+D D+ ++FIGQYT+
Sbjct: 756 GIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTI 814
Query: 721 PWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
P+ C+Q GYRH+ L S G + ++FV+I I
Sbjct: 815 PFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 480 bits (1236), Expect = e-135
Identities = 288/753 (38%), Positives = 426/753 (56%), Gaps = 37/753 (4%)
Query: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77
MQ G ++KVR S R+F L D + + K IS ++ IR G ++E
Sbjct: 17 MQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTET 76
Query: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128
R+ LA+++ + F+I+ +LDL+ANS + A IW+ GL+ LV D +
Sbjct: 77 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
Query: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185
+ R WL F+ D + +G M L+ +N + + F Q +
Sbjct: 137 NQNTPRF-MWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEK 195
Query: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245
+ + EEF + + L R EV L S + + L + + FL+ EQ T ++
Sbjct: 196 LTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 255
Query: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
L++I RYE S+ G+ + L++DGF YL S + DIF+P + QDMTQPL+HY+I +SH
Sbjct: 256 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 315
Query: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365
NTYL+ DQ G + + GYIRALK GCR VE+DV DG EP++ + + +T+ + F+ V+
Sbjct: 316 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 375
Query: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQ--LPSP 423
+ ++AF S+YP+IL L HCS QQ+ MA+ + ++ G +L + + LP++ LPSP
Sbjct: 376 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYT---EAPLPSESYLPSP 432
Query: 424 EELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKK 483
E+L+R I+VKGKKL + D+ E E E EE+E++ + E ++
Sbjct: 433 EKLKRMIIVKGKKLPSDPDV--LEGEVTDEDEEAEMSRRMSVDYNGEQKQIR-------- 482
Query: 484 KSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHN 543
LC LS LV KSV +R F S + +++E+ SFSET+A R+ E +FV +N
Sbjct: 483 -----LCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYN 537
Query: 544 TWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVL 603
LSR+YPS +R DSSN NPQ+ WN GCQ+VAMN QT G MD+ G F QNGGCGYVL
Sbjct: 538 KKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVL 597
Query: 604 KPDFLRDIQSSFHPE-KPISP-FKAQTLLIQVISGQQLPK-VDKTKEGSIVDPLVKVQIF 660
+P +RD S F K I P L I++ISGQ PK +G ++DP V ++I
Sbjct: 598 RPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIH 657
Query: 661 GVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
G+ D + Q T V+ N NP + +T F+V +PELAM+RFVV+D D+ ++FIGQYT+
Sbjct: 658 GIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTI 716
Query: 721 PWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753
P+ C+Q GYRH+ L S G + ++FV+I I
Sbjct: 717 PFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 360 bits (924), Expect = 3e-99
Identities = 238/626 (38%), Positives = 335/626 (53%), Gaps = 75/626 (11%)
Query: 193 EEFVQFYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTSEL------- 244
E+F + + + R ++++LF+ + D LT+ + + FL E Q++ L
Sbjct: 207 EKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAK 266
Query: 245 -ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICS 303
A+++I+ YEP + K + ++S DGF YL S + L +YQ+M PL HYFI S
Sbjct: 267 RAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISS 326
Query: 304 SHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG--EPVVYHGHTLTSRILFK 361
SHNTYL G Q G+SSVE Y + L GCRCVE+D WDG EP++ HG + + ILFK
Sbjct: 327 SHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFK 386
Query: 362 DVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDG--VLPTQ 419
DV+ + + AF TS+YPVILS E HCS QQ M+++ ++ G+ LL L+ + P +
Sbjct: 387 DVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGR 446
Query: 420 -LPSPEELRRKILVKGKKLT--------------------------LEEDLEYE------ 446
LPSP +L+RKIL+K K+L LE+D E E
Sbjct: 447 ALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQ 506
Query: 447 EEEAEPELE-ESELALESQFETEPEPQ-----------EQNLQNKDKKKKSKPILCPALS 494
EEEA PE + +EL+ + E EQ K + + P LS
Sbjct: 507 EEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLS 566
Query: 495 SLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSG 554
+++ Y + V F+ F ++E Y +SSF+E+ +K EFV +N Q+SR+YP G
Sbjct: 567 TMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKG 626
Query: 555 LRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSS 614
R DSSNY PQ WNAGCQMV++N QT L M + G F NG CGY+LKPDF+R +
Sbjct: 627 GRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRT 686
Query: 615 FHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQE-- 670
F P E P+ A T +QVISGQ L DK + V+V ++G+ DT R+E
Sbjct: 687 FDPFSETPVDGVIAATCSVQVISGQFLS--DKK-----IGTYVEVDMYGLPTDTIRKEFR 739
Query: 671 TNYVENNGFNP-YWGQTLCFR-VLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
T V NNG NP Y ++ FR V++P+LA+LR V D N IGQ LP +Q G
Sbjct: 740 TRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAG 795
Query: 729 YRHIHLLSKDGISLRPASIFVYICIQ 754
YRHI L ++ L +IF I ++
Sbjct: 796 YRHISLRNEGNKPLSLPTIFCNIVLK 821
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 360 bits (924), Expect = 3e-99
Identities = 238/626 (38%), Positives = 335/626 (53%), Gaps = 75/626 (11%)
Query: 193 EEFVQFYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTSEL------- 244
E+F + + + R ++++LF+ + D LT+ + + FL E Q++ L
Sbjct: 207 EKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAK 266
Query: 245 -ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICS 303
A+++I+ YEP + K + ++S DGF YL S + L +YQ+M PL HYFI S
Sbjct: 267 RAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISS 326
Query: 304 SHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG--EPVVYHGHTLTSRILFK 361
SHNTYL G Q G+SSVE Y + L GCRCVE+D WDG EP++ HG + + ILFK
Sbjct: 327 SHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFK 386
Query: 362 DVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDG--VLPTQ 419
DV+ + + AF TS+YPVILS E HCS QQ M+++ ++ G+ LL L+ + P +
Sbjct: 387 DVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGR 446
Query: 420 -LPSPEELRRKILVKGKKLT--------------------------LEEDLEYE------ 446
LPSP +L+RKIL+K K+L LE+D E E
Sbjct: 447 ALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQ 506
Query: 447 EEEAEPELE-ESELALESQFETEPEPQ-----------EQNLQNKDKKKKSKPILCPALS 494
EEEA PE + +EL+ + E EQ K + + P LS
Sbjct: 507 EEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLS 566
Query: 495 SLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSG 554
+++ Y + V F+ F ++E Y +SSF+E+ +K EFV +N Q+SR+YP G
Sbjct: 567 TMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKG 626
Query: 555 LRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSS 614
R DSSNY PQ WNAGCQMV++N QT L M + G F NG CGY+LKPDF+R +
Sbjct: 627 GRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRT 686
Query: 615 FHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQE-- 670
F P E P+ A T +QVISGQ L DK + V+V ++G+ DT R+E
Sbjct: 687 FDPFSETPVDGVIAATCSVQVISGQFLS--DKK-----IGTYVEVDMYGLPTDTIRKEFR 739
Query: 671 TNYVENNGFNP-YWGQTLCFR-VLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
T V NNG NP Y ++ FR V++P+LA+LR V D N IGQ LP +Q G
Sbjct: 740 TRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAG 795
Query: 729 YRHIHLLSKDGISLRPASIFVYICIQ 754
YRHI L ++ L +IF I ++
Sbjct: 796 YRHISLRNEGNKPLSLPTIFCNIVLK 821
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 345 bits (886), Expect = 7e-95
Identities = 197/474 (41%), Positives = 279/474 (58%), Gaps = 14/474 (2%)
Query: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTV-WHARQARGSAKPSFSISDVETIRNGHDSE 76
MQEGM M K+R S +R++ L + W R +R + K SI ++ + G SE
Sbjct: 49 MQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRW--RPSRKNEKAKISIDSIQEVSEGRQSE 106
Query: 77 LLRSLAEELPLEQGFTIVFHG-RRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
+ + + ++HG R +LDL++ S E A+ W+ GL+ L+ ++ D
Sbjct: 107 VFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARR 166
Query: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQ-SGTL 190
Q DQWL F DKN DG +S EV +LLH +NV + ++ +F+ ADT GTL
Sbjct: 167 QRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTL 226
Query: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
EEF FYK ++ R ++ L ++S L FLQ EQK T E ++I+
Sbjct: 227 GFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIE 286
Query: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
++EP K + +L +DGF +Y S GDIFNP ++QDMTQPL+HYFI SSHNTYLV
Sbjct: 287 QFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLV 346
Query: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
GDQL QS V+ Y L+ GCRCVEVD WDGP GEP+V+HG+TLTS+ILFKDV+ T+ +Y
Sbjct: 347 GDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKY 406
Query: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
AF ++YPVILS+E HCS QQ+ MA++LT+ILG++L +++ T LPSP+ L+ KI
Sbjct: 407 AFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKI 466
Query: 431 LVKGKKLTLE-----EDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNK 479
LVKGKKL E+ E +E++ E+++ L T + E + K
Sbjct: 467 LVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRK 520
Score = 226 bits (575), Expect = 8e-59
Identities = 129/301 (42%), Positives = 187/301 (62%), Gaps = 17/301 (5%)
Query: 460 ALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYE 519
++E E + P Q+ +KK K L ALS LV Y KSV+ E ++
Sbjct: 595 SVEEGDEGQDSPGGQSRGATRQKKTMK--LSRALSDLVKYTKSVATHDI--EMEAASSWQ 650
Query: 520 ISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNM 579
+SSFSETKA +++++ ++++ N QLSR+YPS R DSSNYNPQ WNAGCQMVA+N
Sbjct: 651 VSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNY 710
Query: 580 QTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQ 637
Q+ G + + F NGGCGYVLKP + Q F+P E P+ + L++++ISGQ
Sbjct: 711 QSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNPNSEDPLPGQLKKQLVLRIISGQ 768
Query: 638 QLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVP 694
QLPK + G I+DP V+V+I G+ +D +R++T V++NGFNP W +TL F V +P
Sbjct: 769 QLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMP 828
Query: 695 ELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQ 754
E+A++RF+V D+D R DFIGQ TL ++ M GYRH++L + ASIFV++ +
Sbjct: 829 EIALVRFLVWDHDPIGR-DFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIFVHVAVS 882
Query: 755 E 755
+
Sbjct: 883 D 883
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 342 bits (878), Expect = 6e-94
Identities = 246/719 (34%), Positives = 375/719 (52%), Gaps = 69/719 (9%)
Query: 87 LEQGFTIVFHG----RRSNLDLMANSVEEAQIWMRGLQLLVD--LVTSMDHQERLDQWLS 140
LEQ V +G S+L+L+A E A+ W + L L +M L++ +
Sbjct: 98 LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYT 157
Query: 141 DWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAAD--TSQSGTLEGEEFVQ- 197
+ +G++ + + RL D++ + +A +S++ ++ E+F
Sbjct: 158 KL--KLQVTPEGRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPE 210
Query: 198 ----FYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTS--------EL 244
F L R E+ +F F A + LT+ + +DF+ +Q++ E
Sbjct: 211 VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ 270
Query: 245 ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSS 304
LI++YEP++S + +S+DGF+ YL ++ + +P L + +DM+QPL+HYFI SS
Sbjct: 271 VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSS 330
Query: 305 HNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGE--PVVYHGHTLTSRILFKD 362
HNTYL QL G SSVE Y + L GCRCVE+D W G + E PV+ HG T+T+ I FK+
Sbjct: 331 HNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKE 390
Query: 363 VVATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLDGVLPTQ-- 419
V+ +A+ AF+TS +P++LS E H S +QQ MA + I G+ LL L+ P +
Sbjct: 391 VIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKY-PLESG 449
Query: 420 --LPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFET------EPEP 471
LPSP +L KILVK KK + + +++ + + S FE E +
Sbjct: 450 VPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADT 509
Query: 472 QEQNLQNKDKKKKS---------KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISS 522
+ + + D KKS + + +S+LV Y++ V F SF SK+ +E+SS
Sbjct: 510 ESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSS 569
Query: 523 FSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTA 582
F ETK + ++ EFV++N QLSR+YP G R DSSNY PQ WNAGCQMVA+N QT
Sbjct: 570 FVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTM 629
Query: 583 GLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLP 640
L M I G + NG GY LKP+F+R F P E + A TL +++ISGQ L
Sbjct: 630 DLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLS 689
Query: 641 KVDKTKEGSIVDPLVKVQIFGVRLDTARQ--ETNYVENNGFNPYWGQ--TLCFRVLVPEL 696
DK V V+V +FG+ +DT R+ +T + N NP W + + +V++P L
Sbjct: 690 --DKK-----VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTL 742
Query: 697 AMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
A LR V + K FIG LP ++ GY +I L ++ L ++FVYI +++
Sbjct: 743 ACLRIAVYEEGGK----FIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKD 797
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 342 bits (878), Expect = 6e-94
Identities = 246/719 (34%), Positives = 375/719 (52%), Gaps = 69/719 (9%)
Query: 87 LEQGFTIVFHG----RRSNLDLMANSVEEAQIWMRGLQLLVD--LVTSMDHQERLDQWLS 140
LEQ V +G S+L+L+A E A+ W + L L +M L++ +
Sbjct: 98 LEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYT 157
Query: 141 DWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAAD--TSQSGTLEGEEFVQ- 197
+ +G++ + + RL D++ + +A +S++ ++ E+F
Sbjct: 158 KL--KLQVTPEGRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPE 210
Query: 198 ----FYKALTKRAEVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTS--------EL 244
F L R E+ +F F A + LT+ + +DF+ +Q++ E
Sbjct: 211 VYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQ 270
Query: 245 ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSS 304
LI++YEP++S + +S+DGF+ YL ++ + +P L + +DM+QPL+HYFI SS
Sbjct: 271 VQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSS 330
Query: 305 HNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGE--PVVYHGHTLTSRILFKD 362
HNTYL QL G SSVE Y + L GCRCVE+D W G + E PV+ HG T+T+ I FK+
Sbjct: 331 HNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKE 390
Query: 363 VVATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLDGVLPTQ-- 419
V+ +A+ AF+TS +P++LS E H S +QQ MA + I G+ LL L+ P +
Sbjct: 391 VIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKY-PLESG 449
Query: 420 --LPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFET------EPEP 471
LPSP +L KILVK KK + + +++ + + S FE E +
Sbjct: 450 VPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADT 509
Query: 472 QEQNLQNKDKKKKS---------KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISS 522
+ + + D KKS + + +S+LV Y++ V F SF SK+ +E+SS
Sbjct: 510 ESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSS 569
Query: 523 FSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTA 582
F ETK + ++ EFV++N QLSR+YP G R DSSNY PQ WNAGCQMVA+N QT
Sbjct: 570 FVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTM 629
Query: 583 GLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLP 640
L M I G + NG GY LKP+F+R F P E + A TL +++ISGQ L
Sbjct: 630 DLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLS 689
Query: 641 KVDKTKEGSIVDPLVKVQIFGVRLDTARQ--ETNYVENNGFNPYWGQ--TLCFRVLVPEL 696
DK V V+V +FG+ +DT R+ +T + N NP W + + +V++P L
Sbjct: 690 --DKK-----VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTL 742
Query: 697 AMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
A LR V + K FIG LP ++ GY +I L ++ L ++FVYI +++
Sbjct: 743 ACLRIAVYEEGGK----FIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKD 797
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 338 bits (866), Expect = 1e-92
Identities = 227/617 (36%), Positives = 318/617 (51%), Gaps = 69/617 (11%)
Query: 195 FVQFYKALTKRAEVQELFESFSADGQKLTLLEFLD-FLQEEQKERDCTSEL--------A 245
+ F +L R E+ E+F S+ A + E L F+ ++Q++ S L
Sbjct: 208 YKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQV 267
Query: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
LID+YEPS R LS +G + +LC + + L ++ DMTQPLNHYFI SSH
Sbjct: 268 QGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSH 327
Query: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDG--PSGEPVVYHGHTLTSRILFKDV 363
NTYL Q G SS E Y + L GCRCVE+D W G P EP++ HG T+T+ I FK+
Sbjct: 328 NTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEA 387
Query: 364 VATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLD--GVLP-TQ 419
+ +A+ AF+TS YP+ILS E H S QQ MA + I G+ LL+ L+ + P
Sbjct: 388 IEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVP 447
Query: 420 LPSPEELRRKILVKGKK------LTLEEDLEYEEEEAEPEL-----------EESELALE 462
LPSPE+LR KIL+K KK + +D E E + P EE E
Sbjct: 448 LPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEE 507
Query: 463 SQFETEPEPQEQNLQNKDKKKKS--------KPILCPALSSLVIYLKSVSFRSFTHSKEH 514
+ E E E + NL ++ KK + +SSLV Y++ F SF S +
Sbjct: 508 EEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQK 567
Query: 515 YHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQM 574
Y ISSF+E KA L+ +A +FV +N Q+SR+YP G R DSSNY PQ WNAGCQM
Sbjct: 568 NRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQM 627
Query: 575 VAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFK--------A 626
VA+N QT L M F NG GY+LK +F+R P+K +PF A
Sbjct: 628 VALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR------RPDKQFNPFSVDRIDVVVA 681
Query: 627 QTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYV--ENNGFNPYWG 684
TL I VISGQ L + V V+V++FG+ D R+ + N NP W
Sbjct: 682 TTLSITVISGQFLSE-------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWK 734
Query: 685 QT--LCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISL 742
+ + ++L+PELA LR VM+ N F+G +P + GY H+ L S+ + L
Sbjct: 735 EEPFVFEKILMPELASLRVAVME----EGNKFLGHRIIPINALNSGYHHLCLHSESNMPL 790
Query: 743 RPASIFVYICIQEGLEG 759
++F+++ +++ + G
Sbjct: 791 TMPALFIFLEMKDYIPG 807
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 337 bits (863), Expect = 3e-92
Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%)
Query: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76
+MQ G M K++ + +R F L ++ T R +R S K I + + G SE
Sbjct: 21 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 79
Query: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
+ AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D
Sbjct: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
Query: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190
Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL
Sbjct: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
Query: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
Query: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL
Sbjct: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
Query: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++
Sbjct: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
Query: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI
Sbjct: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
Query: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466
LVKGKKL + EE E E E+ E +F+
Sbjct: 440 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 475
Score = 209 bits (531), Expect = 1e-53
Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%)
Query: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517
+ T+ E Q K+ +++ LC LS LV+Y SV+ + +
Sbjct: 566 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 624
Query: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
+ SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+
Sbjct: 625 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
Query: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635
N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS
Sbjct: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 740
Query: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V
Sbjct: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 800
Query: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752
+PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I
Sbjct: 801 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 854
Query: 753 IQE 755
I E
Sbjct: 855 INE 857
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 337 bits (863), Expect = 3e-92
Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%)
Query: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76
+MQ G M K++ + +R F L ++ T R +R S K I + + G SE
Sbjct: 21 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 79
Query: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
+ AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D
Sbjct: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
Query: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190
Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL
Sbjct: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
Query: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I
Sbjct: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
Query: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL
Sbjct: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
Query: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++
Sbjct: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
Query: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI
Sbjct: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
Query: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466
LVKGKKL + EE E E E+ E +F+
Sbjct: 440 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 475
Score = 209 bits (531), Expect = 1e-53
Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%)
Query: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517
+ T+ E Q K+ +++ LC LS LV+Y SV+ + +
Sbjct: 566 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 624
Query: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
+ SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+
Sbjct: 625 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
Query: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635
N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS
Sbjct: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 740
Query: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V
Sbjct: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 800
Query: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752
+PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I
Sbjct: 801 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 854
Query: 753 IQE 755
I E
Sbjct: 855 INE 857
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 337 bits (863), Expect = 3e-92
Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%)
Query: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76
+MQ G M K++ + +R F L ++ T R +R S K I + + G SE
Sbjct: 3 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 61
Query: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
+ AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D
Sbjct: 62 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 121
Query: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190
Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL
Sbjct: 122 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 181
Query: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I
Sbjct: 182 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 241
Query: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL
Sbjct: 242 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 301
Query: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++
Sbjct: 302 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 361
Query: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI
Sbjct: 362 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 421
Query: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466
LVKGKKL + EE E E E+ E +F+
Sbjct: 422 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 457
Score = 209 bits (531), Expect = 1e-53
Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%)
Query: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517
+ T+ E Q K+ +++ LC LS LV+Y SV+ + +
Sbjct: 548 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 606
Query: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
+ SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+
Sbjct: 607 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 664
Query: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635
N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS
Sbjct: 665 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 722
Query: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V
Sbjct: 723 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 782
Query: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752
+PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I
Sbjct: 783 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 836
Query: 753 IQE 755
I E
Sbjct: 837 INE 839
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 325 bits (832), Expect = 1e-88
Identities = 231/688 (33%), Positives = 339/688 (49%), Gaps = 97/688 (14%)
Query: 149 NQDGKMSFQEVQRLLHL--MNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRA 206
NQDG++ + + ++ VE E F +++ + E F +F L R
Sbjct: 165 NQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRP 224
Query: 207 EVQELFESFSADGQK-LTLLEFLDFLQEEQKERDCTSEL--------ALELIDRYEPSDS 257
++ ++ A G+ LTL + +DF+ ++Q++ L A LI++YEP+
Sbjct: 225 DIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQ 284
Query: 258 GKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQ 317
R +SM+GF YL ++ I L + DMTQPL+ YFI SSHNTYL QL G
Sbjct: 285 FLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGT 344
Query: 318 SSVEGYIRALKRGCRCVEVDVWDG--PSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTS 375
SSVE Y +AL GCRCVE+DVW G P EP + HG T+T+ + +DV+ +A+ AF+TS
Sbjct: 345 SSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTS 404
Query: 376 DYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLD--GVLP-TQLPSPEELRRKIL 431
YPVILS E H S +QQ MA + I G+ LL LD + P LPSP++L +IL
Sbjct: 405 PYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRIL 464
Query: 432 VKGKK-------------------------------------------------LTLEED 442
VK KK L+ E+
Sbjct: 465 VKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEE 524
Query: 443 LEYEEEEAEPELEESELALE--------SQFETEPEPQEQNLQNKDKK-------KKSKP 487
+ E+ EP+ + L + E E E +E+ Q KK S+
Sbjct: 525 VGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEV 584
Query: 488 ILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQL 547
+S+LV Y++ V F+SF +++ +E+SSF ETKA + ++ EFV++N QL
Sbjct: 585 NATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQL 644
Query: 548 SRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDF 607
SR+YP G R DSSNY PQ WN GCQ+VA+N QT + M + G F NG GY+LKP+F
Sbjct: 645 SRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEF 704
Query: 608 LRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLD 665
+R SF P E + A L ++VISGQ L V V+V +FG+ +D
Sbjct: 705 MRRPDKSFDPFTEVIVDGIVANALRVKVISGQFL-------SDRKVGIYVEVDMFGLPVD 757
Query: 666 TARQ-ETNYVENNGFNPYWGQTLCF--RVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPW 722
T R+ T + N FNP W + +V++P LA LR + K F+G LP
Sbjct: 758 TRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGK----FVGHRILPV 813
Query: 723 TCMQQGYRHIHLLSKDGISLRPASIFVY 750
+ ++ GY ++ L ++ L ++ +Y
Sbjct: 814 SAIRSGYHYVCLRNEANQPLCLPALLIY 841
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 227 bits (578), Expect = 4e-59
Identities = 147/437 (33%), Positives = 237/437 (54%), Gaps = 41/437 (9%)
Query: 53 ARGSAK--PSFSISDVETIRNGHDSELLRSLAEE---LPLEQGFTIVFHG---RRSNLDL 104
+RG+ K + I +++ IR G S E+ P + ++ +G R L L
Sbjct: 63 SRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSL 122
Query: 105 MANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLH 164
A S +E +W++GL L++ ++++WL F D+N++ ++S ++++ +L
Sbjct: 123 QATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLS 182
Query: 165 LMNVEMDQEYAFSLFQAADTSQ-SGTLEGEEFVQFYKALT----KRAEVQELFESFSADG 219
+N + F + D Q SG + +F Q Y++L K ++ L S G
Sbjct: 183 QVNYRVPN-MRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAG 241
Query: 220 QK-----LTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD------SGKLRHV----L 264
++ ++L EF FL + Q E L +DR + + LR +
Sbjct: 242 ERPELCRVSLPEFQQFLLDYQGE--------LWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
Query: 265 SMDGFLSYLCSKDGDIFNPACLPIYQD-MTQPLNHYFICSSHNTYLVGDQLCGQSSVEGY 323
+D F+++L SK+ ++N + D M PL+HY+I SSHNTYL GDQ +SS+E Y
Sbjct: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
Query: 324 IRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSL 383
R L+ GCRC+E+D WDGP G PV+YHGHTLT++I F DV+ T+ ++AF S+YPVILS+
Sbjct: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
Query: 384 ETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDL 443
E HCS QQ+ MA++ ++LG+ LL+ ++ + LPSP +L+RKIL+K KKL E
Sbjct: 414 EDHCSIAQQRNMAQYFKKVLGDTLLTKPVE-ISADGLPSPNQLKRKILIKHKKLA--EGS 470
Query: 444 EYEEEEAEPELEESELA 460
YEE E++++
Sbjct: 471 AYEEVPTSMMYSENDIS 487
Score = 165 bits (417), Expect = 2e-40
Identities = 95/263 (36%), Positives = 144/263 (54%), Gaps = 6/263 (2%)
Query: 493 LSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEA-GNEFVQHNTWQLSRVY 551
LS LV+Y + V F E + ++SSF ETKA++ + +A G +F+Q+N QLSR+Y
Sbjct: 953 LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY 1012
Query: 552 PSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDI 611
P G R DSSNY+P +W G Q+VA+N QT M + F CGYVL+P +RD
Sbjct: 1013 PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDE 1072
Query: 612 QSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQET 671
+ + + + I+V+ + LPK + IV P V++++ G D+ +Q+T
Sbjct: 1073 AFDPFDKSSLRGLEPCAISIEVLGARHLPKNGR----GIVCPFVEIEVAGAEYDSTKQKT 1128
Query: 672 NYVENNGFNPYW-GQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYR 730
+V +NG NP W + F++ PE A LRFVV + D S +F+ Q T P ++ GYR
Sbjct: 1129 EFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYR 1188
Query: 731 HIHLLSKDGISLRPASIFVYICI 753
+ L + L AS+ + I I
Sbjct: 1189 AVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 227 bits (578), Expect = 4e-59
Identities = 147/437 (33%), Positives = 237/437 (54%), Gaps = 41/437 (9%)
Query: 53 ARGSAK--PSFSISDVETIRNGHDSELLRSLAEE---LPLEQGFTIVFHG---RRSNLDL 104
+RG+ K + I +++ IR G S E+ P + ++ +G R L L
Sbjct: 63 SRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSL 122
Query: 105 MANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLH 164
A S +E +W++GL L++ ++++WL F D+N++ ++S ++++ +L
Sbjct: 123 QATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLS 182
Query: 165 LMNVEMDQEYAFSLFQAADTSQ-SGTLEGEEFVQFYKALT----KRAEVQELFESFSADG 219
+N + F + D Q SG + +F Q Y++L K ++ L S G
Sbjct: 183 QVNYRVPN-MRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAG 241
Query: 220 QK-----LTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD------SGKLRHV----L 264
++ ++L EF FL + Q E L +DR + + LR +
Sbjct: 242 ERPELCRVSLPEFQQFLLDYQGE--------LWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
Query: 265 SMDGFLSYLCSKDGDIFNPACLPIYQD-MTQPLNHYFICSSHNTYLVGDQLCGQSSVEGY 323
+D F+++L SK+ ++N + D M PL+HY+I SSHNTYL GDQ +SS+E Y
Sbjct: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
Query: 324 IRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSL 383
R L+ GCRC+E+D WDGP G PV+YHGHTLT++I F DV+ T+ ++AF S+YPVILS+
Sbjct: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
Query: 384 ETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDL 443
E HCS QQ+ MA++ ++LG+ LL+ ++ + LPSP +L+RKIL+K KKL E
Sbjct: 414 EDHCSIAQQRNMAQYFKKVLGDTLLTKPVE-ISADGLPSPNQLKRKILIKHKKLA--EGS 470
Query: 444 EYEEEEAEPELEESELA 460
YEE E++++
Sbjct: 471 AYEEVPTSMMYSENDIS 487
Score = 165 bits (417), Expect = 2e-40
Identities = 95/263 (36%), Positives = 144/263 (54%), Gaps = 6/263 (2%)
Query: 493 LSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEA-GNEFVQHNTWQLSRVY 551
LS LV+Y + V F E + ++SSF ETKA++ + +A G +F+Q+N QLSR+Y
Sbjct: 953 LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY 1012
Query: 552 PSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDI 611
P G R DSSNY+P +W G Q+VA+N QT M + F CGYVL+P +RD
Sbjct: 1013 PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDE 1072
Query: 612 QSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQET 671
+ + + + I+V+ + LPK + IV P V++++ G D+ +Q+T
Sbjct: 1073 AFDPFDKSSLRGLEPCAISIEVLGARHLPKNGR----GIVCPFVEIEVAGAEYDSTKQKT 1128
Query: 672 NYVENNGFNPYW-GQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYR 730
+V +NG NP W + F++ PE A LRFVV + D S +F+ Q T P ++ GYR
Sbjct: 1129 EFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYR 1188
Query: 731 HIHLLSKDGISLRPASIFVYICI 753
+ L + L AS+ + I I
Sbjct: 1189 AVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 219 bits (557), Expect = 1e-56
Identities = 142/409 (34%), Positives = 217/409 (53%), Gaps = 19/409 (4%)
Query: 63 ISDVETIRNGHDS-ELLRSLAEELPLEQGFTIVFHGR--RSNLDLMANSVEEAQIWMRGL 119
I +++ IR G +S + R+ A + FTI++ + S L L A+S E+A W+ GL
Sbjct: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
Query: 120 QLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLF 179
++L + ++ WL D+ + +S +E++ +L L+N ++
Sbjct: 127 KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDK 186
Query: 180 QAADTSQSGTLEGEEFVQFYKALT------------KRAEVQELFESFSADGQKLTLLEF 227
+ L E+F FYK L K + V L + D + L +F
Sbjct: 187 FVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDF 246
Query: 228 LDFLQEEQKER--DCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPAC 285
FL EQ+E +++ + + + L +D FL+YL S++ I++
Sbjct: 247 QRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKY 306
Query: 286 LPI-YQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSG 344
+ QDM PL+HY+I SSHNTYL GDQL +SS E YIR L+ GCRC+E+D WDGP G
Sbjct: 307 DAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDG 366
Query: 345 EPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILG 404
+PV+YHG T T++I F DVV + +AF TS +PVILS+E HCS EQQ+ MA+ E+ G
Sbjct: 367 KPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
Query: 405 EQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPE 453
+ LL+ + QLPSP +LR KI++K KKL D++ E+ + E
Sbjct: 427 DLLLTKPTE-ASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDE 474
Score = 160 bits (405), Expect = 4e-39
Identities = 109/324 (33%), Positives = 166/324 (51%), Gaps = 17/324 (5%)
Query: 447 EEEAEPELEESELALESQFETEPEPQE-----QNLQNKDKKKKSKPILCPALSSLVIYLK 501
+++ +P +E + +E FE +E +N K + + LS LV+Y K
Sbjct: 879 KQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCK 938
Query: 502 SVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSN 561
S + E+ F EI SF ETKA +I++ + +++N L+RVYP G R DSSN
Sbjct: 939 PTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSN 996
Query: 562 YNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPI 621
Y+P LW G QMVA+N QTA M + F NG GYVL+P+ +R + P P
Sbjct: 997 YDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--TEKYDPMPPE 1054
Query: 622 SPFK-AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFN 680
S K TL ++V+ + LPK+ + SI P V+V+I G D + +T V +NG +
Sbjct: 1055 SQRKILMTLTVKVLGARHLPKLGR----SIACPFVEVEICGAEYDNNKFKTTVVNDNGLS 1110
Query: 681 PYWGQT---LCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSK 737
P W T + F + P LA LRFVV + D S +F+ T P ++ G+R + L +
Sbjct: 1111 PIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNG 1170
Query: 738 DGISLRPASIFVYICIQEGLEGDE 761
+ AS+ V+ ++ LE +E
Sbjct: 1171 YSEDIELASLLVFCEMRPVLESEE 1194
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 177 bits (450), Expect = 2e-44
Identities = 122/353 (34%), Positives = 177/353 (50%), Gaps = 72/353 (20%)
Query: 224 LLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIF-N 282
+L+ DFL Q E CT + L +I ++EPS S + ++S +GF +L K+ N
Sbjct: 1326 ILQLNDFLVNCQGEH-CTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKN 1384
Query: 283 PACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGP 342
+++ PL++Y+I SSHNTYL G QL G+SSVE Y + L +GCR VE+D WDG
Sbjct: 1385 DESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGD 1444
Query: 343 SGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEI 402
G P++YHGHTLT++I FK+VV + + AF SD P+I+S+E HCS QQ+ MA +
Sbjct: 1445 DGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTV 1504
Query: 403 LGEQLLSTTL---DGVLPTQLPSPEELRRKILVKGKKLTLEE------------------ 441
GE+L++ L D LPSP++LR+K+L+K KKL +
Sbjct: 1505 FGEKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQV 1564
Query: 442 --------------DLEYEEEEAEPELEESELALESQFETEPEPQEQN--LQ-------- 477
+ E E+EE E + + L+ ++ E PE + N LQ
Sbjct: 1565 QAYNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIP 1624
Query: 478 -----------NK--------------DKKKKSKPILCPALSSLVIYLKSVSF 505
NK D+ KK + P LS LVIY ++V F
Sbjct: 1625 KRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKF 1677
Score = 135 bits (341), Expect = 1e-31
Identities = 79/237 (33%), Positives = 116/237 (48%), Gaps = 13/237 (5%)
Query: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
Y ISS +E AKRL + + QH QL R YP+ R DSSN NP W G Q+VA+
Sbjct: 1755 YHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVAL 1814
Query: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRD----IQSSFHP-EKPISPFKAQTLLIQ 632
N QT L + + F NGGCGYVLKP L D + F P E+ + +
Sbjct: 1815 NYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSMDPAVYSLT 1874
Query: 633 VISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
++SGQ + S+ P ++V + G+ LD+ T + N NP W + F V
Sbjct: 1875 IVSGQNV-----CPSNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFHVH 1929
Query: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFV 749
+L LRF V++ + + Q +P +++GYRH+ L + L +S+F+
Sbjct: 1930 FEDLVFLRFAVVE---NNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 9/101 (8%)
Query: 624 FKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYW 683
F+ TL ++++ Q+LP D + DP VK+ + D + V+ NP+W
Sbjct: 147 FQESTLTVKIMKAQELPAKDFSGTS---DPFVKIYLLP---DKKHKLETKVKRKNLNPHW 200
Query: 684 GQTLCFRVLVPELAMLRFV---VMDYDWKSRNDFIGQYTLP 721
+T F E + R + V+DYD SRND IG+ ++P
Sbjct: 201 NETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIP 241
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 6/99 (6%)
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQ 685
A ++++ +I + L +D G DP VKV + +++T ++ N NP + +
Sbjct: 280 ANSIIVNIIKARNLKAMDI---GGTSDPYVKVWLMYKDKRVEKKKTVTMKRN-LNPIFNE 335
Query: 686 TLCFRVLVPELAMLRFV--VMDYDWKSRNDFIGQYTLPW 722
+ F + +L + VMD D SRND IG+ L W
Sbjct: 336 SFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSW 374
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 47.8 bits (112), Expect = 4e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 8/107 (7%)
Query: 624 FKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYW 683
F++ LL+ ++ L +D G DP V+V + D R+ V NP++
Sbjct: 120 FQSGQLLVGILQAMGLAALDL---GGSSDPYVRVYLLP---DKRRRYETKVHRQTLNPHF 173
Query: 684 GQTLCFRVLVPELA--MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
G+T F+V EL +L V D+D SRND IG+ +P + + G
Sbjct: 174 GETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLG 220
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/108 (26%), Positives = 50/108 (46%), Gaps = 6/108 (5%)
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQ 685
A L + V+ + L K+D G + DP VKV + +++T ++ N NPY+ +
Sbjct: 253 AGKLTVIVLEAKNLKKMDV---GGLSDPYVKVHLLQGGKKVRKKKTT-IKKNTLNPYYNE 308
Query: 686 TLCFRVLVPEL--AMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRH 731
F V ++ + V+DYD +N+ IG+ + G RH
Sbjct: 309 AFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRH 356
>gi|216548478 synaptotagmin XI [Homo sapiens]
Length = 431
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/98 (28%), Positives = 59/98 (60%), Gaps = 7/98 (7%)
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQ 685
AQ + + V+ + LPK+D T G +P VKV ++ R A+++T +V+ NP + +
Sbjct: 305 AQRMTVVVLKARHLPKMDIT--GLSGNPYVKVNVYYGRKRIAKKKT-HVKKCTLNPIFNE 361
Query: 686 TLCFRV---LVPELAMLRFVVMDYDWKSRNDFIGQYTL 720
+ + + L+P+++ + F+V+D+D ++N+ +G+ L
Sbjct: 362 SFIYDIPTDLLPDIS-IEFLVIDFDRTTKNEVVGRLIL 398
Score = 34.7 bits (78), Expect = 0.34
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 10/102 (9%)
Query: 624 FKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYW 683
F + L++ + LP +D +GS DP +K+ I D + V +P +
Sbjct: 169 FPKKALVVTIQEAHGLPVMDDQTQGS--DPYIKMTILP---DKRHRVKTRVLRKTLDPVF 223
Query: 684 GQTLCFRVL----VPELAMLRFVVMDYDWKSRNDFIGQYTLP 721
+T F + + +L +L F+V+ +D SR+D IG+ +P
Sbjct: 224 DETFTFYGIPYSQLQDL-VLHFLVLSFDRFSRDDVIGEVMVP 264
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/158 (27%), Positives = 69/158 (43%), Gaps = 16/158 (10%)
Query: 576 AMNMQT--AGLEMDICDGHFRQNGGCGYVLK-PDFLRDIQSSFHPEKPISPFKAQTLLIQ 632
AMNM+ G + D + + G G K P+ L +Q S + F+A L +
Sbjct: 105 AMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYD-----FQANQLTVG 159
Query: 633 VISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
V+ +LP +D G DP VKV + D ++ V NP + +T F+V
Sbjct: 160 VLQAAELPALDM---GGTSDPYVKVFLLP---DKKKKYETKVHRKTLNPAFNETFTFKVP 213
Query: 693 VPELA--MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
EL L + D+D S++D IG+ +P + G
Sbjct: 214 YQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG 251
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/158 (27%), Positives = 69/158 (43%), Gaps = 16/158 (10%)
Query: 576 AMNMQT--AGLEMDICDGHFRQNGGCGYVLK-PDFLRDIQSSFHPEKPISPFKAQTLLIQ 632
AMNM+ G + D + + G G K P+ L +Q S + F+A L +
Sbjct: 105 AMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYD-----FQANQLTVG 159
Query: 633 VISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
V+ +LP +D G DP VKV + D ++ V NP + +T F+V
Sbjct: 160 VLQAAELPALDM---GGTSDPYVKVFLLP---DKKKKYETKVHRKTLNPAFNETFTFKVP 213
Query: 693 VPELA--MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQG 728
EL L + D+D S++D IG+ +P + G
Sbjct: 214 YQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLG 251
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/110 (27%), Positives = 55/110 (50%), Gaps = 10/110 (9%)
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIF--GVRLDTARQETNYVENNGFNPYW 683
A L + ++ + L K+D G + DP VK+ + G RL +++ ++ N NPY+
Sbjct: 287 AGKLTVVILEAKNLKKMDV---GGLSDPYVKIHLMQNGKRL---KKKKTTIKKNTLNPYY 340
Query: 684 GQTLCFRVLVPELAMLRFVV--MDYDWKSRNDFIGQYTLPWTCMQQGYRH 731
++ F V ++ ++ VV +DYD +ND IG+ + + RH
Sbjct: 341 NESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 624 FKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYW 683
F+ LL+ +I +LP +D G DP VKV + D ++ V NP +
Sbjct: 154 FQNNQLLVGIIQAAELPALDM---GGTSDPYVKVFLLP---DKKKKFETKVHRKTLNPVF 207
Query: 684 GQTLCFRVLVPELA--MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGY 729
+ F+V EL L V D+D S++D IG++ +P + G+
Sbjct: 208 NEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 45.1 bits (105), Expect = 3e-04
Identities = 30/110 (27%), Positives = 55/110 (50%), Gaps = 10/110 (9%)
Query: 626 AQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIF--GVRLDTARQETNYVENNGFNPYW 683
A L + ++ + L K+D G + DP VK+ + G RL +++ ++ N NPY+
Sbjct: 287 AGKLTVVILEAKNLKKMDV---GGLSDPYVKIHLMQNGKRL---KKKKTTIKKNTLNPYY 340
Query: 684 GQTLCFRVLVPELAMLRFVV--MDYDWKSRNDFIGQYTLPWTCMQQGYRH 731
++ F V ++ ++ VV +DYD +ND IG+ + + RH
Sbjct: 341 NESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 624 FKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYW 683
F+ LL+ +I +LP +D G DP VKV + D ++ V NP +
Sbjct: 154 FQNNQLLVGIIQAAELPALDM---GGTSDPYVKVFLLP---DKKKKFETKVHRKTLNPVF 207
Query: 684 GQTLCFRVLVPELA--MLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGY 729
+ F+V EL L V D+D S++D IG++ +P + G+
Sbjct: 208 NEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,026,963
Number of Sequences: 37866
Number of extensions: 1337209
Number of successful extensions: 8060
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 6869
Number of HSP's gapped (non-prelim): 1003
length of query: 762
length of database: 18,247,518
effective HSP length: 110
effective length of query: 652
effective length of database: 14,082,258
effective search space: 9181632216
effective search space used: 9181632216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.