Guide to the Human Genome
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Search of human proteins with 14195601

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14195601 protein phosphatase 1, regulatory (inhibitor)
subunit 12B isoform b [Homo sapiens]
         (998 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...  1954   0.0  
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...  1890   0.0  
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...   840   0.0  
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...   840   0.0  
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun...   729   0.0  
gi|14195599 protein phosphatase 1, regulatory (inhibitor) subuni...   431   e-120
gi|14195597 protein phosphatase 1, regulatory (inhibitor) subuni...   366   e-101
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...   332   1e-90
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni...   206   9e-53
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1...   198   2e-50
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                   127   4e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   110   5e-24
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       106   1e-22
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        106   1e-22
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        106   1e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        106   1e-22
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   106   1e-22
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          102   2e-21
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]      101   3e-21
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   101   3e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    98   4e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         96   2e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         96   2e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         96   2e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         96   2e-19
gi|56090539 dysferlin-interacting protein 1 [Homo sapiens]             96   2e-19
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     96   2e-19
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...    95   4e-19
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                     95   4e-19
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  94   5e-19

>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score = 1954 bits (5062), Expect = 0.0
 Identities = 998/998 (100%), Positives = 998/998 (100%)

Query: 1   MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
           MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
Sbjct: 1   MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60

Query: 61  VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
           VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
Sbjct: 61  VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
           DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
           GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
Sbjct: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240

Query: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
           YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
Sbjct: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300

Query: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
           LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
Sbjct: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360

Query: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
           SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
Sbjct: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420

Query: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
           SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
Sbjct: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480

Query: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
           LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
Sbjct: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540

Query: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
           PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
Sbjct: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600

Query: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
           LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
Sbjct: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660

Query: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
           FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
Sbjct: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720

Query: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
           LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
Sbjct: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780

Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
           EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840

Query: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
           GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
Sbjct: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900

Query: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLK 960
           QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLK
Sbjct: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLK 960

Query: 961 QIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL 998
           QIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL
Sbjct: 961 QIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL 998


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score = 1890 bits (4895), Expect = 0.0
 Identities = 967/988 (97%), Positives = 975/988 (98%), Gaps = 6/988 (0%)

Query: 1   MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60
           MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
Sbjct: 1   MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA 60

Query: 61  VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120
           VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ
Sbjct: 61  VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQ 120

Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
           DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
Sbjct: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180

Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
           GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
Sbjct: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240

Query: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
           YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
Sbjct: 241 YELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300

Query: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360
           LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
Sbjct: 301 LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS 360

Query: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420
           SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
Sbjct: 361 SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS 420

Query: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480
           SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
Sbjct: 421 SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL 480

Query: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540
           LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
Sbjct: 481 LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI 540

Query: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600
           PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
Sbjct: 541 PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV 600

Query: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660
           LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
Sbjct: 601 LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT 660

Query: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720
           FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
Sbjct: 661 FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR 720

Query: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
           LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
Sbjct: 721 LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780

Query: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840
           EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
Sbjct: 781 EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG 840

Query: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900
           GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
Sbjct: 841 GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL 900

Query: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLK 960
           QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK L +  
Sbjct: 901 QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTE-- 958

Query: 961 QIQTLKQMNEQLQAENRALTRVVARLSE 988
               LK  N++L+ EN AL RV+++LS+
Sbjct: 959 ----LKSDNQRLKDENGALIRVISKLSK 982


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
            12A isoform a [Homo sapiens]
          Length = 1030

 Score =  840 bits (2170), Expect = 0.0
 Identities = 507/1059 (47%), Positives = 671/1059 (63%), Gaps = 119/1059 (11%)

Query: 15   ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
            A+ +R EQL+RW GS T+ EP         P+ +R   +V+F+DGAVFLAACSSGDTDEV
Sbjct: 6    AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56

Query: 75   RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
             KLL RGADIN  NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 57   LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116

Query: 135  GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
            GYL+IAE+ I  GA VG VNSEG+ P D+AEE AM++LL  +V +QG+D+E +RKEEE+ 
Sbjct: 117  GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176

Query: 195  MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
            ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 177  MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236

Query: 255  HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
            HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 237  HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296

Query: 314  TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
             ++ LIES  ++++      FKNKE ++ E           E  K  E EE  K+ SS S
Sbjct: 297  KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356

Query: 362  SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
            SEE+E +D  SE+ET+K    KP A V ++N+ S  +    +  P  ++  A   S  ++
Sbjct: 357  SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413

Query: 419  F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
            F   ++ +  K EE KDESP++WRLGLRKTGS+  L+E+  S+E  +++ ++ + RS+SS
Sbjct: 414  FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473

Query: 475  PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
            PR+S+ LDNK+KE+++K    +Y++   PR+L STSDIEEKENR+S+ +L  S SYTR+ 
Sbjct: 474  PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532

Query: 531  WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
            W D+ K N                          +P T +  T               ST
Sbjct: 533  WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592

Query: 553  YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
              K T   S A T         AE + +    S P  V T    P+  N   +T  L+ T
Sbjct: 593  TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651

Query: 605  --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
              GT  S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T 
Sbjct: 652  TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711

Query: 662  SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
             RSR+ R  +++  EK  + +  +   ++ E      +   E +Q + R+ DE    +R 
Sbjct: 712  GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770

Query: 722  RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
              P      TTP+S  ST   SLY SS L   NR +     +S  +   T   E +  + 
Sbjct: 771  --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825

Query: 781  EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
            EE    E  S+  SIRERRRP+E+RR TG++FWT+D DE        T+     KET  +
Sbjct: 826  EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885

Query: 833  RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
             +SR E      T+S S GDR  +   R    + L      +SR+E+D + D+KKLYE  
Sbjct: 886  SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939

Query: 890  LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
            L EN+KLK +L +  +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 940  LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997

Query: 950  EEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 988
            EEE      LK +  LK  N++L+ EN AL RV+++LS+
Sbjct: 998  EEE------LKMLPDLKADNQRLKDENGALIRVISKLSK 1030


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
            isoform a [Homo sapiens]
          Length = 1030

 Score =  840 bits (2170), Expect = 0.0
 Identities = 507/1059 (47%), Positives = 671/1059 (63%), Gaps = 119/1059 (11%)

Query: 15   ARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEV 74
            A+ +R EQL+RW GS T+ EP         P+ +R   +V+F+DGAVFLAACSSGDTDEV
Sbjct: 6    AKQKRNEQLKRWIGSETDLEP---------PVVKRQKTKVKFDDGAVFLAACSSGDTDEV 56

Query: 75   RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
             KLL RGADIN  NVDGLTALHQACID+N+DMVKFLVEN AN+NQ DNEGW PLHAAASC
Sbjct: 57   LKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASC 116

Query: 135  GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
            GYL+IAE+ I  GA VG VNSEG+ P D+AEE AM++LL  +V +QG+D+E +RKEEE+ 
Sbjct: 117  GYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERI 176

Query: 195  MLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPL 254
            ML+DARQWLNSG I DVR A+SG TALHVAAAKGY+EVL+LLIQAGY++N++DYDGWTPL
Sbjct: 177  MLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPL 236

Query: 255  HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK-E 313
            HAAAHWG +EAC IL + LCDM++ NK+GQT FDVADE ++ +LE LQKKQN+L SEK +
Sbjct: 237  HAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRD 296

Query: 314  TRNKLIES--DLNSKIQSGFFKNKEKMLYEE----------ETPKSQEMEEENKESSSSS 361
             ++ LIES  ++++      FKNKE ++ E           E  K  E EE  K+ SS S
Sbjct: 297  KKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESSCS 356

Query: 362  SEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSA---SSARR 418
            SEE+E +D  SE+ET+K    KP A V ++N+ S  +    +  P  ++  A   S  ++
Sbjct: 357  SEEDEEDDSESEAETDK---TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 413

Query: 419  F---SSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSS-IYRSSSS 474
            F   ++ +  K EE KDESP++WRLGLRKTGS+  L+E+  S+E  +++ ++ + RS+SS
Sbjct: 414  FPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTAGVTRSASS 473

Query: 475  PRISALLDNKDKERENK----SYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQL 530
            PR+S+ LDNK+KE+++K    +Y++   PR+L STSDIEEKENR+S+ +L  S SYTR+ 
Sbjct: 474  PRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSS-SLRTSSSYTRRK 532

Query: 531  WRDEAKGN-------------------------EIPQTIAPSTY-------------VST 552
            W D+ K N                          +P T +  T               ST
Sbjct: 533  WEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKSLLSSTST 592

Query: 553  YLKRTPHKSQADTT--------AEKTADNVSSSTPLCVITNRPLPSTANGVTATPVLSIT 604
              K T   S A T         AE + +    S P  V T    P+  N   +T  L+ T
Sbjct: 593  TTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVPTAV-TIPVAPTVVNAAASTTTLTTT 651

Query: 605  --GT-DSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERTF 661
              GT  S+ E RE+RRSYLTPVRDEE+ES RKARSRQARQ+RRSTQGVTLTDLQEAE+T 
Sbjct: 652  TAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTI 711

Query: 662  SRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHRL 721
             RSR+ R  +++  EK  + +  +   ++ E      +   E +Q + R+ DE    +R 
Sbjct: 712  GRSRSTRTREQENEEKEKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYR- 770

Query: 722  RCPAQPDKPTTPASP-STSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN 780
              P      TTP+S  ST   SLY SS L   NR +     +S  +   T   E +  + 
Sbjct: 771  --PVSTSSSTTPSSSLSTMSSSLYASSQL---NRPNSLVGITSAYSRGITKENEREGEKR 825

Query: 781  EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDE--------TDGSEEVKETWHE 832
            EE    E  S+  SIRERRRP+E+RR TG++FWT+D DE        T+     KET  +
Sbjct: 826  EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885

Query: 833  RLSRLESGGSNPTTSDSYGDRASARARREAREARL---ATLTSRVEEDSNRDYKKLYESA 889
             +SR E      T+S S GDR  +   R    + L      +SR+E+D + D+KKLYE  
Sbjct: 886  SISRYE------TSSTSAGDRYDSLLGRSGSYSYLEERKPYSSRLEKDDSTDFKKLYEQI 939

Query: 890  LTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEM 949
            L EN+KLK +L +  +EL D+K +LEK A Q+QE+ +DR S+LEMEKRERRALER++SEM
Sbjct: 940  LAENEKLKAQLHDTNMELTDLKLQLEK-ATQRQERFADR-SLLEMEKRERRALERRISEM 997

Query: 950  EEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 988
            EEE      LK +  LK  N++L+ EN AL RV+++LS+
Sbjct: 998  EEE------LKMLPDLKADNQRLKDENGALIRVISKLSK 1030


>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform b [Homo sapiens]
          Length = 943

 Score =  729 bits (1883), Expect = 0.0
 Identities = 449/968 (46%), Positives = 602/968 (62%), Gaps = 110/968 (11%)

Query: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
           MVKFLVEN AN+NQ DNEGW PLHAAASCGYL+IAE+ I  GA VG VNSEG+ P D+AE
Sbjct: 1   MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60

Query: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
           E AM++LL  +V +QG+D+E +RKEEE+ ML+DARQWLNSG I DVR A+SG TALHVAA
Sbjct: 61  EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
           AKGY+EVL+LLIQAGY++N++DYDGWTPLHAAAHWG +EAC IL + LCDM++ NK+GQT
Sbjct: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180

Query: 286 PFDVADEGLVEHLELLQKKQNVLRSEK-ETRNKLIES--DLNSKIQSGFFKNKEKMLYEE 342
            FDVADE ++ +LE LQKKQN+L SEK + ++ LIES  ++++      FKNKE ++ E 
Sbjct: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240

Query: 343 ----------ETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN 392
                     E  K  E EE  K+ SS SSEE+E +D  SE+ET+K    KP A V ++N
Sbjct: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDK---TKPLASVTNAN 297

Query: 393 SESKSSITEQIPAPAQNTFSA---SSARRF---SSGLFNKPEEPKDESPSSWRLGLRKTG 446
           + S  +    +  P  ++  A   S  ++F   ++ +  K EE KDESP++WRLGLRKTG
Sbjct: 298 TSSTQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTG 357

Query: 447 SHNMLSEVANSREPIRDRGSS-IYRSSSSPRISALLDNKDKERENK----SYISSLAPRK 501
           S+  L+E+  S+E  +++ ++ + RS+SSPR+S+ LDNK+KE+++K    +Y++   PR+
Sbjct: 358 SYGALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRR 417

Query: 502 LNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGN----------------------- 538
           L STSDIEEKENR+S+ +L  S SYTR+ W D+ K N                       
Sbjct: 418 LASTSDIEEKENRDSS-SLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLI 476

Query: 539 --EIPQTIAPSTY-------------VSTYLKRTPHKSQADTT--------AEKTADNVS 575
              +P T +  T               ST  K T   S A T         AE + +   
Sbjct: 477 SSSVPSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK 536

Query: 576 SSTPLCVITNRPLPSTANGVTATPVLSIT--GT-DSSVEAREKRRSYLTPVRDEEAESLR 632
            S P  V T    P+  N   +T  L+ T  GT  S+ E RE+RRSYLTPVRDEE+ES R
Sbjct: 537 DSVPTAV-TIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQR 595

Query: 633 KARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHE 692
           KARSRQARQ+RRSTQGVTLTDLQEAE+T  RSR+ R  +++  EK  + +  +   ++ E
Sbjct: 596 KARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKEKEEKEKQDKEKQEE 655

Query: 693 PSAVPATEAGEGQQPWGRSLDEEPICHRLRCPAQPDKPTTPASP-STSRPSLYTSSHLLW 751
                 +   E +Q + R+ DE    +R   P      TTP+S  ST   SLY SS L  
Sbjct: 656 KKESETSREDEYKQKYSRTYDETYQRYR---PVSTSSSTTPSSSLSTMSSSLYASSQL-- 710

Query: 752 TNRFSVPDSESSETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGIN 811
            NR +     +S  +   T   E +  + EE    E  S+  SIRERRRP+E+RR TG++
Sbjct: 711 -NRPNSLVGITSAYSRGITKENEREGEKREEEKEGEDKSQPKSIRERRRPREKRRSTGVS 769

Query: 812 FWTKDEDE--------TDGSEEVKETWHERLSRLESGGSNPTTSDSYGDRASARARREAR 863
           FWT+D DE        T+     KET  + +SR E      T+S S GDR  +   R   
Sbjct: 770 FWTQDSDENEQEQQSDTEEGSNKKETQTDSISRYE------TSSTSAGDRYDSLLGRSGS 823

Query: 864 EARL---ATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQ 920
            + L      +SR+E+D + D+KKLYE  L EN+KLK +L +  +EL D+K +LEK A Q
Sbjct: 824 YSYLEERKPYSSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEK-ATQ 882

Query: 921 KQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALT 980
           +QE+ +DR S+LEMEKRERRALER++SEMEEE      LK +  LK  N++L+ EN AL 
Sbjct: 883 RQERFADR-SLLEMEKRERRALERRISEMEEE------LKMLPDLKADNQRLKDENGALI 935

Query: 981 RVVARLSE 988
           RV+++LS+
Sbjct: 936 RVISKLSK 943



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 43/173 (24%), Positives = 82/173 (47%), Gaps = 17/173 (9%)

Query: 33  QEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGL 92
           Q    R+G   +   R+   R+   D   +L   +SG  ++VR   + G           
Sbjct: 69  QNEVNRQGVDIEA-ARKEEERIMLRDARQWL---NSGHINDVRHAKSGG----------- 113

Query: 93  TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
           TALH A      +++K L++   +VN +D +GWTPLHAAA  G        +++   + +
Sbjct: 114 TALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEM 173

Query: 153 VNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNS 205
           VN  G+   D+A+E  +    LE+++K+   L   +++++  +++      N+
Sbjct: 174 VNKVGQTAFDVADEDILG--YLEELQKKQNLLHSEKRDKKSPLIESTANMDNN 224


>gi|14195599 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform d [Homo sapiens]
          Length = 224

 Score =  431 bits (1107), Expect = e-120
 Identities = 224/224 (100%), Positives = 224/224 (100%)

Query: 775 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 834
           MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL
Sbjct: 1   MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 60

Query: 835 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 894
           SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ
Sbjct: 61  SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 120

Query: 895 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 954
           KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK
Sbjct: 121 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 180

Query: 955 NLHQLKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL 998
           NLHQLKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL
Sbjct: 181 NLHQLKQIQTLKQMNEQLQAENRALTRVVARLSESIESSDTQEL 224


>gi|14195597 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform c [Homo sapiens]
          Length = 208

 Score =  366 bits (940), Expect = e-101
 Identities = 193/214 (90%), Positives = 201/214 (93%), Gaps = 6/214 (2%)

Query: 775 MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 834
           MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL
Sbjct: 1   MDKNENEEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERL 60

Query: 835 SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 894
           SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ
Sbjct: 61  SRLESGGSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQ 120

Query: 895 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 954
           KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK
Sbjct: 121 KLKTKLQEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMK 180

Query: 955 NLHQLKQIQTLKQMNEQLQAENRALTRVVARLSE 988
            L +      LK  N++L+ EN AL RV+++LS+
Sbjct: 181 VLTE------LKSDNQRLKDENGALIRVISKLSK 208


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score =  332 bits (851), Expect = 1e-90
 Identities = 246/732 (33%), Positives = 350/732 (47%), Gaps = 95/732 (12%)

Query: 9   GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
           G  A +AR RR EQLR+W           R GA   P  RR    VRFE  A FLAAC+ 
Sbjct: 12  GAAAAAARERRREQLRQW---------GARAGAEPGPGERRART-VRFERAAEFLAACAG 61

Query: 69  GDTDEVRKLLARGAD------------------INTVNVDGLTALHQACIDENLDMVKFL 110
           GD DE R L+ R AD                  +++ N DG++ALHQACIDENL++V+FL
Sbjct: 62  GDLDEAR-LMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120

Query: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
           VE  A VNQ DNEGWTPLH AASCGYL+IA Y ++HGA++  VNS+G++P DLAE  AM+
Sbjct: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180

Query: 171 DLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
            LL  ++ ++G+D+E +++ EE+ +L D R WLN G + + R  R+GA+ALHVAAAKGY 
Sbjct: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240

Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           EV+RLL+QAGY+  ++D DGWTPLHAAAHWGV++AC +LAE    MD     GQ P D+A
Sbjct: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300

Query: 291 DEGLVEHLELLQKKQNVLRSEKE---TRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKS 347
           DE ++  LE L +KQ  LR++KE   +R +  ++  +SK +    ++    L   E    
Sbjct: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHR----RSSVCRLSSREKISL 356

Query: 348 QEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPA 407
           Q++ +E +   +     ++ EDE  E  TE                          P PA
Sbjct: 357 QDLSKERRPGGAGGPPIQD-EDEGEEGPTE--------------------------PPPA 389

Query: 408 QNTFSASSARRFSSGLFNKPEEP--KDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRG 465
           +      +    SS     P+ P   +E+P S R GL KTGS   L      R      G
Sbjct: 390 E----PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGP-PERRTAEGAPG 444

Query: 466 SSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGS 525
           + + RS+SS  +        + R   + I+     KL   S + E          + + S
Sbjct: 445 AGLQRSASSSWLEGTSTQAKELR--LARITPTPSPKLPEPSVLSEVTKPPPC---LENSS 499

Query: 526 YTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITN 585
              ++   E+     P     ST      +      Q     E++     + + L   + 
Sbjct: 500 PPSRIPEPESPAK--PNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557

Query: 586 RPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRS 645
           R    +  GVT T +             EK    L P R      +  + S   R     
Sbjct: 558 R----STQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPD 613

Query: 646 TQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGLEGSPEKHEPSAVPATEAGEG 704
            QG      +E  +     R   + +E +P ++  ++  LEG P                
Sbjct: 614 GQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR------------- 660

Query: 705 QQPWGRSLDEEP 716
           +Q W R L+ EP
Sbjct: 661 RQRWQRDLNPEP 672



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 111/423 (26%), Positives = 178/423 (42%), Gaps = 54/423 (12%)

Query: 589 PSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQG 648
           P T NGV++ P  S        EA   RR  L       A              RR+ +G
Sbjct: 391 PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGA---------LGPPERRTAEG 441

Query: 649 VTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPW 708
                LQ +  +        QA+E    + T T     SP+  EPS +      E  +P 
Sbjct: 442 APGAGLQRSASSSWLEGTSTQAKELRLARITPTP----SPKLPEPSVL-----SEVTKP- 491

Query: 709 GRSLDEEPICHRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSES------ 762
              L+      R+  P  P KP  P + ST+ P+   S     + +  V D ES      
Sbjct: 492 PPCLENSSPPSRIPEPESPAKPNVPTA-STAPPA--DSRDRRRSYQMPVRDEESESQRKA 548

Query: 763 -------SETTTNTTTAKEMDKNENEEADLDEQSSKRLSIRERRRPKE---RRRGTGINF 812
                  S  +T   T  ++ + E       E      S+   RRP+        +    
Sbjct: 549 RSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQR 608

Query: 813 WTKDEDETDGSEEVKETWHERLSRLESG---GSNPTTSDSYGDRASAR----ARREAREA 865
               + +  G +  +E  H ++ +   G   G     +D   + ++      ARR+  + 
Sbjct: 609 AEAPDGQGPGPQAARE--HRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQR 666

Query: 866 RLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKVAQQKQEKT 925
            L        E+ +  ++ LY     EN++L+  L E  L LA +K +LE+ A Q+QE+ 
Sbjct: 667 DLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELER-ATQRQERF 725

Query: 926 SDRSSVLEMEKRERRALERKMSEMEEEMKNLHQLKQIQTLKQMNEQLQAENRALTRVVAR 985
           ++R ++LE+E+ ERRALERK +E+EEE      LK +  L+  N++L+ EN AL RV+++
Sbjct: 726 AERPALLELERFERRALERKAAELEEE------LKALSDLRADNQRLKDENAALIRVISK 779

Query: 986 LSE 988
           LS+
Sbjct: 780 LSK 782


>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
           16A [Homo sapiens]
          Length = 528

 Score =  206 bits (524), Expect = 9e-53
 Identities = 132/404 (32%), Positives = 207/404 (51%), Gaps = 18/404 (4%)

Query: 10  KRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP----RVRFEDGAVFLAA 65
           +R + A+ RRA+Q++ W  +  E+E   ++G G +P     S     +V F    V L A
Sbjct: 21  ERLKHAQKRRAQQVKMW--AQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEA 78

Query: 66  CSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGW 125
            +  D +EVR+ L  G   +  N DGLTALHQ CID+  +MV+ L+E  AN+N  D+E W
Sbjct: 79  AARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECW 138

Query: 126 TPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI--- 182
           TPLHAAA+CG+L++ E  I  GA++  VN++G +P DL ++    D L   +  +GI   
Sbjct: 139 TPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQD 198

Query: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARS-GATALHVAAAKGYSEVLRLLIQAGY 241
            +E +R   E +ML D R  L +G   D+      GAT LHVAAA G+SE   LL++   
Sbjct: 199 SIEAARAVPELRMLDDIRSRLQAG--ADLHAPLDHGATLLHVAAANGFSEAAALLLEHRA 256

Query: 242 ELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA--DEGLVEHLE 299
            L+ +D DGW PLHAAA+WG      +L     D++ ++ + +TP DV   +E   + LE
Sbjct: 257 SLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLE 316

Query: 300 LLQKKQNVLRSEKETRNKL----IESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENK 355
           L  K   +LR++   R+ L      +    K+       +   LY ++  +   + ++  
Sbjct: 317 LKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPP 376

Query: 356 ESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSI 399
            +S    E+ +     +E       +  PE    H+     S +
Sbjct: 377 PTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPV 420


>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
           [Homo sapiens]
          Length = 567

 Score =  198 bits (504), Expect = 2e-50
 Identities = 127/387 (32%), Positives = 197/387 (50%), Gaps = 17/387 (4%)

Query: 10  KRAESARMRRAEQLRRWRGSLTEQEPAER-RGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
           +R  +A+ RRA+QL++W  +  EQ+   R R   R+  T     +V FE     L A   
Sbjct: 21  ERLRAAQKRRAQQLKKW--AQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLR 78

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
            D +EVR  L      +  N DGLTALHQ CID   ++VK L+ + ANVN +DNE WTPL
Sbjct: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLE--- 185
           HAAA+CG++N+ +  + +GA +  VNS+G +P DL E+    D++   +  QGI  E   
Sbjct: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198

Query: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245
           + R   EQQM+ D    + +G+  D   A+ GAT LH+A A GY     LL+  G  ++V
Sbjct: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDV 257

Query: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEG--LVEHLELLQK 303
           +D+DGW PLHAAA WG  +   +L      +  R  + + P D+ +E    V  LEL  K
Sbjct: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHK 317

Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFK--------NKEKMLYEEETPKSQEMEEENK 355
              +++S+   ++ L     ++  +    +        N  +  YE E    Q    E++
Sbjct: 318 HDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQ 377

Query: 356 ESSSSSSEEEEGEDEASESETEKEADK 382
            +S+ + +  E   +    +     +K
Sbjct: 378 RTSTYNGDIRETRTDQENKDPNPRLEK 404


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score =  127 bits (320), Expect = 4e-29
 Identities = 88/297 (29%), Positives = 145/297 (48%), Gaps = 10/297 (3%)

Query: 9   GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAG-RQPLTRRGSPRVRFEDGAVFLAACS 67
           G+R    +  R EQ++ +     E+E A ++  G  + L    +P+V F    +   A  
Sbjct: 14  GQRQRLVKRMRCEQIKAYY----EREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAII 69

Query: 68  SGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTP 127
             +  EV +LL  GAD +T+   G + LH     +N  + + L++   NVN QD + WTP
Sbjct: 70  HHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTP 129

Query: 128 LHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA-EEPAMKDLLLEQVKKQGID--- 183
           +H A +C   +I    +  GA+V + +  G +P D A E      +LL  + + G+D   
Sbjct: 130 MHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTS 189

Query: 184 LEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYEL 243
           L Q + +    ML D + +L+SG   + +    G T LH+A A GY EV+ L+++ G +L
Sbjct: 190 LRQMKLQRPMSMLTDVKHFLSSGGNVNEKN-DEGVTLLHMACASGYKEVVSLILEHGGDL 248

Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL 300
           N+ D   WTPLH AA +G      +L     +  + N   +   D+A    +E + L
Sbjct: 249 NIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLL 305



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 39/118 (33%), Positives = 66/118 (55%), Gaps = 4/118 (3%)

Query: 73  EVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAA 132
           +V+  L+ G ++N  N +G+T LH AC     ++V  ++E+  ++N  D++ WTPLH AA
Sbjct: 204 DVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAA 263

Query: 133 SCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKE 190
             G  N+ +  + H A+  +VN   E  SD+A    ++++LL    K  I  E+  KE
Sbjct: 264 KYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLL----KAEIAWEEKMKE 317


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  110 bits (276), Expect = 5e-24
 Identities = 73/236 (30%), Positives = 117/236 (49%), Gaps = 10/236 (4%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           L A      D    LLA GAD N V+ DG   LH A  + +    + L+++ A V+ Q+ 
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
           EGWTPLH AA   + N+A   ++  A   +  +EG+ P  +A        L++ +  QG 
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS-LVKLLTSQGA 518

Query: 183 DLEQSRKE--------EEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLR 234
           +L+  ++          E+  ++  +  L SG + D    +SG   LH AAA+G   + +
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAARGKYLICK 577

Query: 235 LLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           +L++ G  L +  + GWTPLH AA+ G  E   +LAE+  +M     +  TP  +A
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 65/227 (28%), Positives = 98/227 (43%), Gaps = 16/227 (7%)

Query: 75  RKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASC 134
           R L++R AD N    +G T LH A    ++ +VK L    A ++ Q     TPLH A   
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537

Query: 135 GYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQ 194
           G +   ++ +  GA    ++  G  P   A     K L+ + + + G  LE    +    
Sbjct: 538 GKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG-KYLICKMLLRYGASLELPTHQGWTP 596

Query: 195 MLQDARQWLNSGKIEDVR-----QARSGA------TALHVAAAKGYSEVLRLLIQAGYEL 243
           +   A +    G +E +       A  GA      T LH+AA  G   V+  L+Q G + 
Sbjct: 597 LHLAAYK----GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652

Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           N  +  GWTPLH A       +   L E   ++  RNK+G TP  +A
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLA 699



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 57/213 (26%), Positives = 93/213 (43%), Gaps = 28/213 (13%)

Query: 92  LTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVG 151
           +T LH      +++ V+ L+ +  +V+ Q   G+TPL  AA     ++    + HGA   
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 152 IVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDV 211
            V+ +G  P   A +              G D               AR  L+ G   D 
Sbjct: 423 RVDEDGWAPLHFAAQ-------------NGDD-------------GTARLLLDHGACVDA 456

Query: 212 RQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAE 271
            Q R G T LH+AA   +  V RLL+    + N+ + +G TPLH AA++G      +L  
Sbjct: 457 -QEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515

Query: 272 ALCDMDIRNKLGQTPFDVA-DEGLVEHLELLQK 303
              ++D + +  +TP  +A + G V  ++ L K
Sbjct: 516 QGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 65/269 (24%), Positives = 120/269 (44%), Gaps = 19/269 (7%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           ++R+  P +   +G   L  A   G    V+ L ++GA+++    +  T LH A     +
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
             ++ L+++ A  +  D  G+ PLH AA+ G   I +  + +GAS+ +   +G  P  LA
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 165 EEPAMKD---LLLEQVKKQGI-------DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQA 214
                 +   LL E     G         L  + +  E+ ++      L  G   +  + 
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL---LQCGADPNAAE- 656

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
           +SG T LH+A  +     +  L++    ++ ++  GWTP H AA  G      +L EA  
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 275 DMDIRNKLGQTPFDVA----DEGLVEHLE 299
            +D+++ +  TP  +A     +G++  LE
Sbjct: 717 QLDVQDGVSCTPLQLALRSRKQGIMSFLE 745


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  106 bits (265), Expect = 1e-22
 Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)

Query: 6   HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
           H+  KR  +  ++    R  Q+  + R  LT    A R G  +  + L  RG+P + R +
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309

Query: 58  DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   L   + GD  E V+ LL   A ++ V +D LTALH A    +  + K L++ RAN
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
            N +   G+TPLH A     + + E  + +GAS+  +   G  P  +A      +++L  
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429

Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
           ++     D+   R E    M   A Q       L +G + D R AR   T LH+A+  G 
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 488

Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
           +E+++LL+Q     +    +G+TPLH +A  G  +  S+L EA     +  K G TP  V
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548

Query: 290 ADE-GLVEHLELLQKKQ 305
           A + G ++  +LL +++
Sbjct: 549 AAKYGSLDVAKLLLQRR 565



 Score =  103 bits (258), Expect = 6e-22
 Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G    V++LL RG+ +++    G TALH A +    ++VK LV+  AN+N Q   G
Sbjct: 50  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
           +TPL+ AA   ++++ +Y + +GA+      +G  P  +A +        +LLE   K  
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169

Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
           + L      +RK++ +    +LQ+                                  A 
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
             LN G   D   AR+G T LHVA+ +G + +++LL+  G +++ +  DG TPLH AA  
Sbjct: 230 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
           G  +   +L E    +  R K G +P  +A +G  +H+E    LLQ K  V
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 337



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL + A+ N   ++G T LH AC    + +++ LV+  A++      G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            TP+H AA  G+LNI    + +GAS  + N  GE    +A      +++   ++     L
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 468

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
             +R  EEQ  L  A +    GK E V+              +G T LH++A +G  +V 
Sbjct: 469 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            +L++AG   ++    G+TPLH AA +G  +   +L +     D   K G TP  VA
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 109/451 (24%), Positives = 185/451 (41%), Gaps = 66/451 (14%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  D  + LL R A  ++   +GLT LH A   +N  +   L+E  A+ +     G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + IA   +N+GA   IV  +G  P  LA +    D++   + K G ++
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 667

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
             S K                          SG T+LH+AA +    V  +L + G + +
Sbjct: 668 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 701

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPL  A H+G  +  + L +   +++ + K G TP    A +G    + +L  
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 759

Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
            Q+  +    T N      +  ++      +  K++ EE T  +  + E++K +   +  
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 819

Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
           E      EEG+D  +         E   E   D  P +       ++ +S    +S    
Sbjct: 820 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 879

Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
              +   +T S +S  R S+ + +    P        K+   +S+RL     G+ N L  
Sbjct: 880 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 935

Query: 454 VANSREPIRDRGSS--IYRSSSSPRISALLD 482
           VA S  PI    +S  + R +SS  +S ++D
Sbjct: 936 VALSSSPIHSGRASPCLERDNSSFLVSFMVD 966



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
           G  D    LL  GA  +     G T LH A    +LD+ K L++ RA  +     G TPL
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 579

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
           H AA      +A   +  GAS       G  P  +A                        
Sbjct: 580 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 615

Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
              ++  +Q A   LN G   ++   + G T LH+A+ +G+++++ LL+  G  +++   
Sbjct: 616 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672

Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            G T LH AA         IL +   D D   KLG TP  VA
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G+ +    LL RGA ++    +G+T LH A    N +MVK L++    ++ +  +G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
            TPLH AA  G+  + E  +  GA +      G  P  +A +      +K LL  +    
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338

Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
            + L+                 ++L D R   N+       +A +G T LH+A  K   +
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 391

Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           V+ LL++ G  +      G TP+H AA  G      +L +     D+ N  G+T   +A
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 24/79 (30%), Positives = 40/79 (50%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + AC  G+   V  LL +GA++N    +G T LHQA    +  ++  L+++ A  N    
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 771

Query: 123 EGWTPLHAAASCGYLNIAE 141
            G T L  A   GY+++ +
Sbjct: 772 NGNTALAIAKRLGYISVVD 790


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  106 bits (265), Expect = 1e-22
 Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)

Query: 6   HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
           H+  KR  +  ++    R  Q+  + R  LT    A R G  +  + L  RG+P + R +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 58  DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   L   + GD  E V+ LL   A ++ V +D LTALH A    +  + K L++ RAN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
            N +   G+TPLH A     + + E  + +GAS+  +   G  P  +A      +++L  
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
           ++     D+   R E    M   A Q       L +G + D R AR   T LH+A+  G 
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 509

Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
           +E+++LL+Q     +    +G+TPLH +A  G  +  S+L EA     +  K G TP  V
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 290 ADE-GLVEHLELLQKKQ 305
           A + G ++  +LL +++
Sbjct: 570 AAKYGSLDVAKLLLQRR 586



 Score =  103 bits (258), Expect = 6e-22
 Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G    V++LL RG+ +++    G TALH A +    ++VK LV+  AN+N Q   G
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
           +TPL+ AA   ++++ +Y + +GA+      +G  P  +A +        +LLE   K  
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
           + L      +RK++ +    +LQ+                                  A 
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
             LN G   D   AR+G T LHVA+ +G + +++LL+  G +++ +  DG TPLH AA  
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
           G  +   +L E    +  R K G +P  +A +G  +H+E    LLQ K  V
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 358



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL + A+ N   ++G T LH AC    + +++ LV+  A++      G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            TP+H AA  G+LNI    + +GAS  + N  GE    +A      +++   ++     L
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 489

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
             +R  EEQ  L  A +    GK E V+              +G T LH++A +G  +V 
Sbjct: 490 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            +L++AG   ++    G+TPLH AA +G  +   +L +     D   K G TP  VA
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 64/428 (14%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  D  + LL R A  ++   +GLT LH A   +N  +   L+E  A+ +     G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + IA   +N+GA   IV  +G  P  LA +    D++   + K G ++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
             S K                          SG T+LH+AA +    V  +L + G + +
Sbjct: 689 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPL  A H+G  +  + L +   +++ + K G TP    A +G    + +L  
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 780

Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
            Q+  +    T N      +  ++      +  K++ EE T  +  + E++K +   +  
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840

Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
           E      EEG+D  +         E   E   D  P +       ++ +S    +S    
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900

Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
              +   +T S +S  R S+ + +    P        K+   +S+RL     G+ N L  
Sbjct: 901 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 956

Query: 454 VANSREPI 461
           VA S  PI
Sbjct: 957 VALSSSPI 964



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
           G  D    LL  GA  +     G T LH A    +LD+ K L++ RA  +     G TPL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
           H AA      +A   +  GAS       G  P  +A                        
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 636

Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
              ++  +Q A   LN G   ++   + G T LH+A+ +G+++++ LL+  G  +++   
Sbjct: 637 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693

Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            G T LH AA         IL +   D D   KLG TP  VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G+ +    LL RGA ++    +G+T LH A    N +MVK L++    ++ +  +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
            TPLH AA  G+  + E  +  GA +      G  P  +A +      +K LL  +    
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
            + L+                 ++L D R   N+       +A +G T LH+A  K   +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 412

Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           V+ LL++ G  +      G TP+H AA  G      +L +     D+ N  G+T   +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 24/79 (30%), Positives = 40/79 (50%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + AC  G+   V  LL +GA++N    +G T LHQA    +  ++  L+++ A  N    
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792

Query: 123 EGWTPLHAAASCGYLNIAE 141
            G T L  A   GY+++ +
Sbjct: 793 NGNTALAIAKRLGYISVVD 811


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  106 bits (265), Expect = 1e-22
 Identities = 94/317 (29%), Positives = 153/317 (48%), Gaps = 18/317 (5%)

Query: 6   HLGGKRAESARMR----RAEQL-RRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
           H+  KR  +  ++    R  Q+  + R  LT    A R G  +  + L  RG+P + R +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330

Query: 58  DGAVFLAACSSGDTDE-VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   L   + GD  E V+ LL   A ++ V +D LTALH A    +  + K L++ RAN
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
            N +   G+TPLH A     + + E  + +GAS+  +   G  P  +A      +++L  
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 177 VKK-QGIDLEQSRKEEEQQMLQDARQ------WLNSGKIEDVRQARSGATALHVAAAKGY 229
           ++     D+   R E    M   A Q       L +G + D R AR   T LH+A+  G 
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR-AREEQTPLHIASRLGK 509

Query: 230 SEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
           +E+++LL+Q     +    +G+TPLH +A  G  +  S+L EA     +  K G TP  V
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 569

Query: 290 ADE-GLVEHLELLQKKQ 305
           A + G ++  +LL +++
Sbjct: 570 AAKYGSLDVAKLLLQRR 586



 Score =  103 bits (258), Expect = 6e-22
 Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 51/291 (17%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G    V++LL RG+ +++    G TALH A +    ++VK LV+  AN+N Q   G
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKD---LLLEQVKKQG 181
           +TPL+ AA   ++++ +Y + +GA+      +G  P  +A +        +LLE   K  
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 182 IDLE----QSRKEEEQQ---MLQD----------------------------------AR 200
           + L      +RK++ +    +LQ+                                  A 
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 201 QWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHW 260
             LN G   D   AR+G T LHVA+ +G + +++LL+  G +++ +  DG TPLH AA  
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309

Query: 261 GVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE----LLQKKQNV 307
           G  +   +L E    +  R K G +P  +A +G  +H+E    LLQ K  V
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQG--DHVECVKHLLQHKAPV 358



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 69/237 (29%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL + A+ N   ++G T LH AC    + +++ LV+  A++      G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            TP+H AA  G+LNI    + +GAS  + N  GE    +A      +++   ++     L
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA--L 489

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAAAKGYSEVL 233
             +R  EEQ  L  A +    GK E V+              +G T LH++A +G  +V 
Sbjct: 490 VDARAREEQTPLHIASRL---GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            +L++AG   ++    G+TPLH AA +G  +   +L +     D   K G TP  VA
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 64/428 (14%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  D  + LL R A  ++   +GLT LH A   +N  +   L+E  A+ +     G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + IA   +N+GA   IV  +G  P  LA +    D++   + K G ++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK-GANI 688

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
             S K                          SG T+LH+AA +    V  +L + G + +
Sbjct: 689 HMSTK--------------------------SGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPL  A H+G  +  + L +   +++ + K G TP    A +G    + +L  
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL-- 780

Query: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSE 363
            Q+  +    T N      +  ++      +  K++ EE T  +  + E++K +   +  
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT 840

Query: 364 E------EEGEDEAS---------ESETEKEADKKPEA-------FVNHSNSESKSSITE 401
           E      EEG+D  +         E   E   D  P +       ++ +S    +S    
Sbjct: 841 EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR 900

Query: 402 QIPAPAQNTFSASSARRFSSGLFNKPEEP--------KDESPSSWRLGLRKTGSHNMLSE 453
              +   +T S +S  R S+ + +    P        K+   +S+RL     G+ N L  
Sbjct: 901 SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRL---SWGTEN-LDN 956

Query: 454 VANSREPI 461
           VA S  PI
Sbjct: 957 VALSSSPI 964



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 62/222 (27%), Positives = 90/222 (40%), Gaps = 27/222 (12%)

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
           G  D    LL  GA  +     G T LH A    +LD+ K L++ RA  +     G TPL
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSR 188
           H AA      +A   +  GAS       G  P  +A                        
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA------------------------ 636

Query: 189 KEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
              ++  +Q A   LN G   ++   + G T LH+A+ +G+++++ LL+  G  +++   
Sbjct: 637 --AKKNQMQIASTLLNYGAETNI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693

Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
            G T LH AA         IL +   D D   KLG TP  VA
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 63/239 (26%), Positives = 103/239 (43%), Gaps = 20/239 (8%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G+ +    LL RGA ++    +G+T LH A    N +MVK L++    ++ +  +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE----PAMKDLLLEQVKKQ 180
            TPLH AA  G+  + E  +  GA +      G  P  +A +      +K LL  +    
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359

Query: 181 GIDLE---------QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSE 231
            + L+                 ++L D R   N+       +A +G T LH+A  K   +
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNA-------RALNGFTPLHIACKKNRIK 412

Query: 232 VLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           V+ LL++ G  +      G TP+H AA  G      +L +     D+ N  G+T   +A
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 80/378 (21%), Positives = 148/378 (39%), Gaps = 33/378 (8%)

Query: 349  EMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQ 408
            +M E+ +E    S EE++ E   +E       + +  ++   +    +  I +     A 
Sbjct: 2721 KMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAM 2780

Query: 409  NTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSE-----VANSREPIRD 463
            +   +SSA   SSGL +   +  DE P  ++  L   G+H   +E     V+ +  P  D
Sbjct: 2781 SP--SSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQAD 2838

Query: 464  RGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRS 523
              S  + SSSS     + + K+ + E+ S  SS+   ++  T +  E   ++      + 
Sbjct: 2839 CPSESFSSSSSLPHCLVSEGKELD-EDISATSSIQKTEVTKTDETFENLPKDCP---SQD 2894

Query: 524  GSYTRQLWR--------DEAKGNEI--PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADN 573
             S T Q  R        D A+ +EI  PQ  +P   V +    +  +S+  T A  T   
Sbjct: 2895 SSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSF 2954

Query: 574  VSSSTPLCVITNR----PLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAE 629
             SS      IT+      + S+++G   +   +  G D  +E++++   +     D  + 
Sbjct: 2955 HSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLW-EMQSDSVSS 3013

Query: 630  SLRKARSRQARQTRRSTQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGL---- 684
            S     S            V +T       ++S  R + +A E + +E+     GL    
Sbjct: 3014 SFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDR 3073

Query: 685  --EGSPEKHEPSAVPATE 700
              +G+     P+  P  E
Sbjct: 3074 QSQGTTPDTTPARTPTEE 3091



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 24/79 (30%), Positives = 40/79 (50%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + AC  G+   V  LL +GA++N    +G T LHQA    +  ++  L+++ A  N    
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792

Query: 123 EGWTPLHAAASCGYLNIAE 141
            G T L  A   GY+++ +
Sbjct: 793 NGNTALAIAKRLGYISVVD 811



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 124/669 (18%), Positives = 241/669 (36%), Gaps = 113/669 (16%)

Query: 299  ELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESS 358
            E L+K   +LRS   TR++       S +QS   +++  ++ EE    S E  EE ++ +
Sbjct: 1557 EDLEKVNEILRSGTCTRDE-------SSVQSS--RSERGLVEEEWVIVSDEEIEEARQKA 1607

Query: 359  SSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARR 418
                 E    +   + E + + +K     VN+   +  + +   +P     T    + ++
Sbjct: 1608 PLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVP--LPKEQLQTVQDKAGKK 1665

Query: 419  FSSGLFNKPEE------PKDESPSSWR-----LGLRKTGSHNMLSEVANSREPIRDRGSS 467
              +    +  E      P DE+ S+ +     LG++K     +       +E  + +   
Sbjct: 1666 CEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKL-------KEKQKQKEEG 1718

Query: 468  IYRSSSSPRISALLDNKDKERENKSYISSLAPRKL---NSTSDIEEKENRESAVNLVRSG 524
            +  S+    +      K    E+      LAP  L    +TS + E+    S  + V++ 
Sbjct: 1719 LQASAEKAELK-----KGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKA- 1772

Query: 525  SYTRQLWRDEAKG-NEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVI 583
               ++   DE KG +++P  +     V       PH + + +   K+  +   S      
Sbjct: 1773 --LQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSL--KSERHAPGSPSPKTE 1828

Query: 584  TNRPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTR 643
             +  L S+A      PV        S  ++ ++ S ++P    E  S   + S+  + + 
Sbjct: 1829 RHSTLSSSAKTERHPPV--------SPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSP 1880

Query: 644  RSTQGVTLTDLQEAERTFSRSRAERQAQEQPREKPTDTEGLE--GSPEKHEPSAVPATEA 701
             S    T     E     S ++ ER     P  K      +   G  EKH P +   TE 
Sbjct: 1881 VSPSTKT-----ERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEK 1935

Query: 702  GEGQQPWGRSLDEEPIC-------HRLRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNR 754
                 P GR+   +P+        H    P+   +   P SP++    +  +  +    +
Sbjct: 1936 RLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMK 1995

Query: 755  FSVPDSESSETTTNT---TTAKEMDKNENEEADLDEQSSKRLSIRERRRPK--------- 802
                  + S+  T      +AK+    E  +  ++++    L+ RE ++ +         
Sbjct: 1996 AFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQR 2055

Query: 803  -------ERRRGTGI-NFWTKDEDETDGSEEV--------KETWHERLSRLESGGSNPTT 846
                   E +RG  + +   K ED   G E+V         ++  E  S  ES       
Sbjct: 2056 LPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKM 2115

Query: 847  SDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQK-----LKTKLQ 901
            +D  GD                 L    +  ++ D+ ++ +  L +N K     L  + +
Sbjct: 2116 ADEQGD---------------MDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE 2160

Query: 902  EAQLELADI 910
            +AQL L  +
Sbjct: 2161 KAQLHLDQV 2169


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  106 bits (265), Expect = 1e-22
 Identities = 68/237 (28%), Positives = 113/237 (47%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL + A+ N   ++G T LH AC    + +++ L+++ A++      G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            TP+H AA  G++NI    ++HGAS    N  GE    +A      + ++  + + G  +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE-VVRYLVQDGAQV 492

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQ-----------ARSGATALHVAAAKGYSEVL 233
           E   K+++  +   AR     GK + V+Q             SG T LH++A +G+ +V 
Sbjct: 493 EAKAKDDQTPLHISAR----LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
             L+  G  L++    G+TPLH AA +G  E  ++L +     D   K G TP  VA
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605



 Score =  101 bits (252), Expect = 3e-21
 Identities = 78/274 (28%), Positives = 130/274 (47%), Gaps = 39/274 (14%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  + V +LL R A+++     G TALH A +    ++VK LV N ANVN Q   G
Sbjct: 81  ASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNG 140

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA---MKDLLLEQVKKQG 181
           +TPL+ AA   +L + ++ +++GAS  +   +G  P  +A +     +  LLLE   K  
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGK 200

Query: 182 IDLE----QSRKEEEQQ---MLQD--------------------------ARQWLNSGKI 208
           + L      +RK++ +    +LQ+                          A   LN    
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260

Query: 209 EDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
            D   AR+  T LHVA+ +G + +++LL+  G +++ +  DG TPLH  A  G ++   +
Sbjct: 261 VDF-TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319

Query: 269 LAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQ 302
           L +    +  + K G +P  +A +G  +HL  +Q
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQG--DHLNCVQ 351



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 70/264 (26%), Positives = 123/264 (46%), Gaps = 8/264 (3%)

Query: 32  EQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDG 91
           E+EP ++R   ++   R+     + +  A +L A  +G  ++    +  G DIN  N +G
Sbjct: 19  EEEPEKKRKHRKRSRDRKK----KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNG 74

Query: 92  LTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVG 151
           L ALH A  + ++++V  L++  ANV+    +G T LH A+  G   + +  + +GA+V 
Sbjct: 75  LNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN 134

Query: 152 IVNSEGEVPSDLAEEP---AMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKI 208
             +  G  P  +A +     +   LL+    Q +  E          LQ     + S  +
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG-FTPLAVALQQGHDQVVSLLL 193

Query: 209 EDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
           E+  + +    ALH+AA K  ++   LL+Q     +V+   G+TPLH AAH+G     ++
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATL 253

Query: 269 LAEALCDMDIRNKLGQTPFDVADE 292
           L      +D   +   TP  VA +
Sbjct: 254 LLNRAAAVDFTARNDITPLHVASK 277



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 88/320 (27%), Positives = 144/320 (45%), Gaps = 26/320 (8%)

Query: 6   HLGGKRAESARM-----RRAEQLRRWRGSLTEQEPAERRGAGR--QPLTRRGSPRV-RFE 57
           H+  KR  +  +     R A+   + R  LT      R G  +  + L  R +P + + +
Sbjct: 273 HVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK 332

Query: 58  DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   L   + GD  + V+ LL     ++ V  D LTALH A    +  + K L++ +AN
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
            N +   G+TPLH A     + + E  + HGAS+  V   G  P  +A      + ++ Q
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN-IVSQ 451

Query: 177 VKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVR-----------QARSGATALHVAA 225
           +   G     +    E  +   AR    SG+ E VR           +A+   T LH++A
Sbjct: 452 LMHHGASPNTTNVRGETALHMAAR----SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISA 507

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
             G +++++ L+Q G   N     G+TPLH +A  G ++  + L +    + I  K G T
Sbjct: 508 RLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFT 567

Query: 286 PFDVADE-GLVEHLELLQKK 304
           P  VA + G +E   LL +K
Sbjct: 568 PLHVAAKYGKLEVANLLLQK 587



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 70/253 (27%), Positives = 103/253 (40%), Gaps = 35/253 (13%)

Query: 38  RRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQ 97
           + GA  Q +T  G   +          A   G  + V +L+  GA  NT NV G TALH 
Sbjct: 421 KHGASIQAVTESGLTPIH--------VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHM 472

Query: 98  ACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157
           A      ++V++LV++ A V  +  +  TPLH +A  G  +I +  +  GAS     + G
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 158 EVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSG 217
             P  L+     +D+                          A   L+ G    +   + G
Sbjct: 533 YTPLHLSAREGHEDV--------------------------AAFLLDHGASLSI-TTKKG 565

Query: 218 ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD 277
            T LHVAA  G  EV  LL+Q     +     G TPLH AAH+  ++   +L +      
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625

Query: 278 IRNKLGQTPFDVA 290
              K G TP  +A
Sbjct: 626 AAAKNGYTPLHIA 638



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 64/231 (27%), Positives = 106/231 (45%), Gaps = 14/231 (6%)

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
           G  D V++LL +GA  N     G T LH +  + + D+  FL+++ A+++    +G+TPL
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA---EEPAMKDLLLEQ-------VK 178
           H AA  G L +A   +   AS       G  P  +A   +   +  LLL+Q        K
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629

Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
                L  + K+ +  +   A   L  G   +    R G  ++H+AA +G+ +++ LL+ 
Sbjct: 630 NGYTPLHIAAKKNQMDI---ATTLLEYGADANA-VTRQGIASVHLAAQEGHVDMVSLLLG 685

Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289
               +N+ +  G TPLH AA         +L      +D + K+G TP  V
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 60/217 (27%), Positives = 88/217 (40%), Gaps = 28/217 (12%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           L +  SP    ++G   L  A      D    LL  GAD N V   G+ ++H A  + ++
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
           DMV  L+   ANVN  +  G TPLH AA    +N+AE  +N GA V      G  P  + 
Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737

Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
                       +K     L+ S K                       + ++G T LH A
Sbjct: 738 -------CHYGNIKIVNFLLQHSAKVN--------------------AKTKNGYTPLHQA 770

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
           A +G++ ++ +L+Q     N    +G T L  A   G
Sbjct: 771 AQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLG 807



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 39/121 (32%), Positives = 55/121 (45%), Gaps = 8/121 (6%)

Query: 40  GAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQAC 99
           GA    +TR+G   V          A   G  D V  LL R A++N  N  GLT LH A 
Sbjct: 654 GADANAVTRQGIASVHL--------AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705

Query: 100 IDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEV 159
            ++ +++ + LV   A+V+ Q   G+TPLH     G + I  + + H A V      G  
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765

Query: 160 P 160
           P
Sbjct: 766 P 766


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  106 bits (264), Expect = 1e-22
 Identities = 94/326 (28%), Positives = 155/326 (47%), Gaps = 16/326 (4%)

Query: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE 123
           AA S+G  + V+ LL  G +I+ +NV G TALH AC +    +V  L++  ANVNQ +N 
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246

Query: 124 GWTPLH-AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
           G+TPLH AAAS       E  +N+GA V I + +G+ P  +      +    + + + G 
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG-RFTRSQTLIQNGG 305

Query: 183 DLEQSRKEEEQQMLQDARQ----WLNSGKIEDVRQARSGATA---LHVAAAKGYSEVLRL 235
           +++   K+    +   AR      +N+ +      A+ G  +   LH+AA   +S+  R 
Sbjct: 306 EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRK 365

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
           L+ +G+E++  D  G T LHAAA  G  E   +L  +  D   ++K G+TP   A     
Sbjct: 366 LLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCH 425

Query: 296 EHL--ELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEE 353
            H    L+    NV  ++   R     + L+    S   +NK  +    +  +  E   E
Sbjct: 426 FHCIETLVTTGANVNETDDWGR-----TALHYAAASDMDRNKTILGNAHDNSEELERARE 480

Query: 354 NKESSSSSSEEEEGEDEASESETEKE 379
            KE  ++   E   +++A+ S  +KE
Sbjct: 481 LKEKEATLCLEFLLQNDANPSIRDKE 506



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 74/245 (30%), Positives = 126/245 (51%), Gaps = 12/245 (4%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +  +D  RKLL+ G +I+T +  G T LH A    N++ +K L  + A+ +++D  G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAM--KDLLLEQVKKQGI 182
            TPLH AA+  + +  E  +  GA+V   +  G      A    M     +L        
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473

Query: 183 DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ---A 239
           +LE++R+ +E++        L +     +R  + G  ++H AAA G+ + L LL++   +
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAYGHRQCLELLLERTNS 532

Query: 240 GYELNVQDYDGWT--PLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVE 296
           G+E   +   G T  PLH AA+ G  +A  +L ++L D+DIR++ G+T  D+A  +G  E
Sbjct: 533 GFE---ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTE 589

Query: 297 HLELL 301
            +E L
Sbjct: 590 CVEAL 594



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 28/227 (12%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +G  + V  LLA+GA+IN  +     ALH A    +LD+V  L+ + A V  +D +G
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLHAAAS G +N+ ++ +N G  +  +N  G     +A     +D ++ ++   G ++
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG-QDAVVNELIDYGANV 240

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEV-LRLLIQAGYEL 243
            Q                             +G T LH AAA  +  + L LL+  G ++
Sbjct: 241 NQPN--------------------------NNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 244 NVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           N+Q  DG +PLH  A  G       L +   ++D  +K G TP  VA
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 64/225 (28%), Positives = 100/225 (44%), Gaps = 33/225 (14%)

Query: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128
           GD + +  L+  GA +N  +   LT LH+A    + + V+ L+++ A+VN +D    TPL
Sbjct: 27  GDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPL 86

Query: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVP---SDLAEEPAMKDLLLEQVKKQGIDLE 185
           H AA+   +  AE  I   +SV + +  G      + L     M +LLL     +G ++ 
Sbjct: 87  HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL----AKGANIN 142

Query: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245
              K++ +                          ALH AA  G+ +V+ LLI  G E+  
Sbjct: 143 AFDKKDRR--------------------------ALHWAAYMGHLDVVALLINHGAEVTC 176

Query: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
           +D  G+TPLHAAA  G       L     ++D  N  G T   +A
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 13/232 (5%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A +S   + V+ L+   AD+N  + +  T LH A  ++ +   + ++   ++VN  D  G
Sbjct: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            T LH AA  G++ +    +  GA++   + +       A      D++   +   G ++
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI-NHGAEV 174

Query: 185 EQSRKE--------EEQQMLQDARQWLNSG-KIEDVRQARSGATALHVAAAKGYSEVLRL 235
               K+             +   +  LN G +I+++     G TALH+A   G   V+  
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINV--YGNTALHIACYNGQDAVVNE 232

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEAC-SILAEALCDMDIRNKLGQTP 286
           LI  G  +N  + +G+TPLH AA       C  +L     D++I++K G++P
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 70/283 (24%), Positives = 119/283 (42%), Gaps = 41/283 (14%)

Query: 64  AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE 123
           AA + G+ + ++ L + GAD +  +  G T LH A  + +   ++ LV   ANVN+ D+ 
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDW 445

Query: 124 GWTPLHAAASCGYLN----------------------------IAEYFINHGASVGIVNS 155
           G T LH AA+                                   E+ + + A+  I + 
Sbjct: 446 GRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDK 505

Query: 156 EGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQA- 214
           EG      A     +  L   +++     E+S     +  L  A    +   +E + Q+ 
Sbjct: 506 EGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSL 565

Query: 215 -------RSGATALHVAAAKGYSEVLRLLIQAGYELNVQD-YDGWTPLHAAAHWGVKEAC 266
                    G TAL +AA KG++E +  LI  G  + V+D     TPLHA+   G     
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625

Query: 267 SILAEALCD---MDIRNKLGQTPFDVA-DEGLVEHLELLQKKQ 305
            +L E   +   +D+++  GQTP  +A   G ++ + LL +K+
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 64/241 (26%), Positives = 109/241 (45%), Gaps = 15/241 (6%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + A + G  D V  LL + A+++TV++ G TALH+  +  + + V+ L+E   ++  +D+
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGAS---VGIVNSEGEVPSDLA----EEPAMKDLLLE 175
            G TPLH AA+ G+       +    S       +++G  P   A     E  ++ LL +
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769

Query: 176 QVKKQGI-----DLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
           +  ++ I      L  +   +           ++S  I   R  + G T L  AA   + 
Sbjct: 770 KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS-SIVSCRDDK-GRTPLRAAAFADHV 827

Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILA-EALCDMDIRNKLGQTPFDV 289
           E L+LL++    +N  D  G T L  AA  G   A  IL   A  D+ +++K   TP  +
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887

Query: 290 A 290
           A
Sbjct: 888 A 888



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 56/223 (25%), Positives = 100/223 (44%), Gaps = 13/223 (5%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN-E 123
           A  +G    +  LL    D++  +  G TAL  A    + + V+ L+   A++  +DN  
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608

Query: 124 GWTPLHAAASCGY---LNIAEYFINHGASVGIVNSEGEVPSDLA----EEPAMKDLLLEQ 176
             TPLHA+   G+   L +     ++  +V + +++G+ P  LA       A+  LL ++
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 177 VKKQGIDLEQSRKEEEQQML--QDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLR 234
                +D+          M   ++  Q L   ++  + +   G T LH AAA+G++  L 
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728

Query: 235 LLIQAGY---ELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            L+Q      +   +D  G+TPLH A + G +    +L E  C
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 35/85 (41%), Positives = 47/85 (55%), Gaps = 1/85 (1%)

Query: 207 KIEDVRQARSGA-TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEA 265
           K EDV    S   T LHVAA  G +E++ LLI +G  +N +D    TPLH A     +EA
Sbjct: 5   KTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64

Query: 266 CSILAEALCDMDIRNKLGQTPFDVA 290
             +L +   D++ R+K  QTP  VA
Sbjct: 65  VQVLIKHSADVNARDKNWQTPLHVA 89



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 62/246 (25%), Positives = 92/246 (37%), Gaps = 36/246 (14%)

Query: 64  AACSSGDTDEVRKLLARGADINTVNVD---GLTALHQACIDENLDMVKFLVENRANVNQQ 120
           A+  +G T  +R LL    +   V+V    G T L  A    ++D V  L+E  ANV+  
Sbjct: 615 ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674

Query: 121 DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ 180
           D  G T LH     G+    +  +    S+   +S G  P   A        L E     
Sbjct: 675 DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE----- 729

Query: 181 GIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG 240
              L Q    EE    +D                  G T LH A   G    + +L++  
Sbjct: 730 ---LLQMALSEEDCCFKD----------------NQGYTPLHWACYNGNENCIEVLLE-- 768

Query: 241 YELNVQDYDG--WTPLHAAAHWGVKEACSILAEALCD--MDIRNKLGQTPFDVADEGLVE 296
            +   + + G  +TPLH A         S+L  A+    +  R+  G+TP   A     +
Sbjct: 769 -QKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA--AFAD 825

Query: 297 HLELLQ 302
           H+E LQ
Sbjct: 826 HVECLQ 831



 Score = 37.4 bits (85), Expect = 0.071
 Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 2/104 (1%)

Query: 55  RFEDGAVFLAACSSGDTDEVRKLLAR-GADINTVNVDGLTALHQACIDENLDMVKFLVEN 113
           R + G   L A +  D  E  +LL R  A +N V+  G TAL  A  +     V  LV +
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869

Query: 114 -RANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE 156
            +A++  +D +  TPLH A S G+   A   ++      ++N +
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  102 bits (253), Expect = 2e-21
 Identities = 87/292 (29%), Positives = 129/292 (44%), Gaps = 37/292 (12%)

Query: 44  QPLTRRGSPRVRFED----GAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQAC 99
           Q L +RGS R+  +D     AV+ AA   G  D ++ L      ++  +  G  ALH A 
Sbjct: 396 QLLIKRGS-RIDVQDKGGSNAVYWAA-RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAA 453

Query: 100 IDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEV 159
              + D+ + L    +N N QD E  TPLH AA  GY ++A+     G +V I N EGE 
Sbjct: 454 RYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGET 513

Query: 160 PSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGAT 219
           P   A      D++ E + + G DL    K+                          G  
Sbjct: 514 PLLTASARGYHDIV-ECLAEHGADLNACDKD--------------------------GHI 546

Query: 220 ALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIR 279
           ALH+A  +   EV++ L+  G  ++ QD  G TPLH A   G       L EA C++DI 
Sbjct: 547 ALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS 606

Query: 280 NKLGQTPFDVADEG----LVEHLELLQKKQNVLRSEKETRNKLIESDLNSKI 327
           NK G+TP  +A       +V +L L+      L ++ +T   L  S+ +  +
Sbjct: 607 NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHV 658



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 57/197 (28%), Positives = 90/197 (45%), Gaps = 29/197 (14%)

Query: 92  LTALHQACIDENLDMVKFLVENRAN--VNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
           + A+  A  D+N+  ++ L+ + +N  VNQ +  G  PL  AA CG + I +  I  G+ 
Sbjct: 345 MKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSR 404

Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
           + + +  G      A      D L                           ++L+  K  
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTL---------------------------KFLSENKCP 437

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
              + +SG  ALHVAA  G+++V +LL   G   N+QD +  TPLH AA  G       L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497

Query: 270 AEALCDMDIRNKLGQTP 286
            EA C+++I+N+ G+TP
Sbjct: 498 CEAGCNVNIKNREGETP 514



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 40/126 (31%), Positives = 69/126 (54%), Gaps = 5/126 (3%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           ++ LL++G  ++  +  G T LH AC D N+ +V  L E   N++  +  G TPLH AA+
Sbjct: 560 IKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 619

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQVKK---QGIDLEQSR 188
            G L++  Y    GASV  + ++G+   DLA     + +  LL +++K   +G+ ++Q R
Sbjct: 620 NGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLR 679

Query: 189 KEEEQQ 194
             +  Q
Sbjct: 680 PTQNLQ 685



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 5/110 (4%)

Query: 210 DVRQA-RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSI 268
           DV Q  + G   L +AA  G  ++L+LLI+ G  ++VQD  G   ++ AA  G  +    
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430

Query: 269 LAEALCDMDIRNKLGQTPFDVADE-GLVEHLELL---QKKQNVLRSEKET 314
           L+E  C +D+++K G+    VA   G  +  +LL       N+   E+ET
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET 480


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score =  101 bits (252), Expect = 3e-21
 Identities = 78/258 (30%), Positives = 127/258 (49%), Gaps = 30/258 (11%)

Query: 63  LAACSSGDTDEVRKLLAR-------------GADINTVNVDGLTALHQACIDENLDMVKF 109
           + A  +GD   V+KL+A+               ++N  + DG +ALH A +  +L+++  
Sbjct: 8   ILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIAL 67

Query: 110 LVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAM 169
           L+E +A V+ +D+ G  PLH AA  G L      +   A+V   + +G++P  LA +   
Sbjct: 68  LLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGH 127

Query: 170 KDL------------LLEQVKKQGIDL--EQSRKEEEQQMLQD-ARQWLNSGKIEDVRQA 214
            ++            L+ + KK  +DL  E  R +  Q +L       L  G+ +D    
Sbjct: 128 YEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDP 187

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            +  T LH+AA  G+ EV+R L++AG E+N Q   G T LH AA +G  E   +L E   
Sbjct: 188 -NYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEGGV 245

Query: 275 DMDIRNKLGQTPFDVADE 292
           D++IRN   QT  D+ ++
Sbjct: 246 DVNIRNTYNQTALDIVNQ 263



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 69/241 (28%), Positives = 112/241 (46%), Gaps = 26/241 (10%)

Query: 54  VRFEDGAVFLA---ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFL 110
           V ++D   F A   A   G  + +  LL   A ++  + +G+  LH A     L+ V+ L
Sbjct: 42  VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101

Query: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
           +   A VN    +G  PLH AA  G+  ++E  + H ++  +VN   + P DLA E    
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRL 161

Query: 171 DL------------LLEQVKKQGID------LEQSRKEEEQQMLQDARQWLNSGKIEDVR 212
            +            LLE   K   D      L  + K   ++++   RQ L +G IE  R
Sbjct: 162 KVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVI---RQLLRAG-IEINR 217

Query: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272
           Q ++G TALH AA  G +EV+RLL++ G ++N+++    T L     +   +A   + + 
Sbjct: 218 QTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQL 276

Query: 273 L 273
           L
Sbjct: 277 L 277


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  101 bits (252), Expect = 3e-21
 Identities = 81/278 (29%), Positives = 129/278 (46%), Gaps = 49/278 (17%)

Query: 77  LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
           LL +GA+IN    + LT LH A    + D+V+ +V++ A VN  DN G T LH AA CG+
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445

Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQML 196
           L      +++G    I++ +G     +  E       ++Q+ ++GI L  S  E ++Q+L
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNEN------VQQLLQEGISLGNS--EADRQLL 497

Query: 197 QDAR-------------QWLNSGKIE---------------------------DVR-QAR 215
           + A+             Q +N   IE                           DV  + +
Sbjct: 498 EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557

Query: 216 SGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCD 275
            G   LH A + G+ EV  LL++ G  +NV D   +TPLH AA  G  E C +L +   D
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 617

Query: 276 MDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKE 313
              +N+ G TP D+  +G  +  +LL+    +L + K+
Sbjct: 618 PTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 87/290 (30%), Positives = 132/290 (45%), Gaps = 32/290 (11%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  D V  LL  GA++   +  GL  LH AC   + ++V  L+ + A+ N +DN  
Sbjct: 65  AAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWN 124

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA  G +++    + HGA   I N++G    DLA +P+ K +L  + KK  + L
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA-DPSAKAVLTGEYKKDEL-L 182

Query: 185 EQSRKEEEQQML------------QDARQ--------WLNSGKI--------EDVRQARS 216
           E +R   E++M+             D R+          N  KI         DV     
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242

Query: 217 G-ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCD 275
           G    LH A + G+ EV  LL++ G  +N  D   +TPLH AA     E CS+L     D
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302

Query: 276 MDIRNKLGQTPFDVA-DEGLVEHLELLQKKQNVLRSEKETRNKLIESDLN 324
             + N   ++  D+A    L E L    K  ++L++ +E     I+  L+
Sbjct: 303 PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLS 352



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 78/245 (31%), Positives = 112/245 (45%), Gaps = 31/245 (12%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V  LL  GAD++  +  GL  LH AC   + ++ + LV++ A VN  D   +TPLH AA+
Sbjct: 542 VEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAE--EPAMKDLL--------------LEQV 177
            G   I +  + HGA     N +G  P DL +  +  ++DLL              L +V
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARV 661

Query: 178 KK------------QGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVR-QARSGATALHVA 224
           KK            QG              L+ A   L  G   DV  Q + G   LH A
Sbjct: 662 KKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHG--ADVNAQDKGGLIPLHNA 719

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQ 284
           A+ G+ +V  LLI+    +N  D   +TPLH AA  G  + C++L     D  ++N+ GQ
Sbjct: 720 ASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQ 779

Query: 285 TPFDV 289
           TP D+
Sbjct: 780 TPLDL 784



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 60/215 (27%), Positives = 108/215 (50%), Gaps = 9/215 (4%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL  GAD++  +   L  LH AC   + ++ + LV++ A VN  D   +TPLH AAS
Sbjct: 227 VQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAAS 286

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQ 193
              + +    +++GA   ++N   +   DLA  P +K+ L  + K  G  L Q+ +E + 
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFK--GHSLLQAAREADV 344

Query: 194 QMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGY---SEVLRLLIQAGYELNVQDYDG 250
             ++       S ++ + +  ++  TALH AAA  Y    ++  LL++ G  +N +  + 
Sbjct: 345 TRIKKHL----SLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEF 400

Query: 251 WTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
            TPLH A+     +   ++ +    ++  + LGQT
Sbjct: 401 LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQT 435



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 35/97 (36%), Positives = 48/97 (49%)

Query: 77  LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
           LL  GAD+N  +  GL  LH A    ++D+   L++  A VN  D   +TPLH AA  G 
Sbjct: 698 LLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGR 757

Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLL 173
             +    + HGA   + N EG+ P DL     +  LL
Sbjct: 758 TQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 51/168 (30%), Positives = 74/168 (44%), Gaps = 36/168 (21%)

Query: 95  LHQACIDENLDMVKFLVENRANVNQQDNEGW--TPLHAAASCGYLNIAEYFINHGASVGI 152
           L +AC + +++ VK LV     VN +D  G   TPLH AA  G  ++ EY + +GA+V  
Sbjct: 28  LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 153 VNSEGEVPSDLA---EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
            +  G +P   A       + +LLL    + G D              +AR   N     
Sbjct: 87  RDDGGLIPLHNACSFGHAEVVNLLL----RHGAD-------------PNARDNWN----- 124

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAA 257
                    T LH AA KG  +V  +L+Q G E  +++ DG T L  A
Sbjct: 125 --------YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 39/147 (26%), Positives = 69/147 (46%), Gaps = 4/147 (2%)

Query: 207 KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEAC 266
           K+     A   +T LH AA  G  +V+  L+Q G  +  +D  G  PLH A  +G  E  
Sbjct: 48  KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVV 107

Query: 267 SILAEALCDMDIRNKLGQTPF-DVADEGLVE-HLELLQKKQNVLRSEKETRNKLIESDLN 324
           ++L     D + R+    TP  + A +G ++  + LLQ          + R  L  +D +
Sbjct: 108 NLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPS 167

Query: 325 SK-IQSGFFKNKEKMLYEEETPKSQEM 350
           +K + +G +K K+++L    +   ++M
Sbjct: 168 AKAVLTGEYK-KDELLESARSGNEEKM 193


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 72/238 (30%), Positives = 120/238 (50%), Gaps = 7/238 (2%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  D V  LL  GA+++  +  GL  LH AC   + ++V  L+   A+ N +DN  
Sbjct: 223 AAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWN 282

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA  G +++    + HGA   I N++G+   DLA +P+ K +L  + KK  + L
Sbjct: 283 YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-DPSAKAVLTGEYKKDEL-L 340

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
           E +R   E++++        +    D R+    +T LH+AA      +++LL+Q G +++
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRK----STPLHLAAGYNRVRIVQLLLQHGADVH 396

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELL 301
            +D  G  PLH A  +G  E   +L +    ++  +    TP  + A +  VE   LL
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 72/229 (31%), Positives = 118/229 (51%), Gaps = 11/229 (4%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL  GAD++  +  GL  LH AC   + ++ + L+++ A VN  D   +TPLH AAS
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQ 193
              + +    ++HGA   +VN  G+   D+A  P +++ L  + K  G  L Q+ +E + 
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK--GHSLLQAAREAD- 501

Query: 194 QMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGY---SEVLRLLIQAGYELNVQDYDG 250
             L   ++ L + +I + +Q +S  TALH A A  +    +V  LL++ G  +N ++ D 
Sbjct: 502 --LAKVKKTL-ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDF 558

Query: 251 WTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLE 299
            TPLH AA     +   +L +    M+  + LGQT    A   L  HL+
Sbjct: 559 MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRA--ALAGHLQ 605



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 74/244 (30%), Positives = 113/244 (46%), Gaps = 27/244 (11%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V  LL  GAD++  +  GL  LH AC   + ++ + LV + A+VN  D   +TPLH AA+
Sbjct: 700 VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAA 759

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEE--PAMKDL------LLEQVKKQGIDLE 185
            G   I +  + HGA     N +G  P DL +E    ++DL      LL+  KK  +   
Sbjct: 760 KGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARV 819

Query: 186 QSRKEEEQQMLQDAR-------------------QWLNSGKIEDVRQARSGATALHVAAA 226
           Q     E    +D +                   ++L     +   Q + G   LH AA+
Sbjct: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAAS 879

Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
            G+ ++  LLI+    +N  D   +TPLH AA  G  + C++L     D  ++N+ GQTP
Sbjct: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939

Query: 287 FDVA 290
            D+A
Sbjct: 940 LDLA 943



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 76/271 (28%), Positives = 129/271 (47%), Gaps = 35/271 (12%)

Query: 77  LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
           LL +GA++N  N D +T LH A    + D+++ L ++ A +N  D  G T LH AA  G+
Sbjct: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603

Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ--VKKQGID---LEQSRKEE 191
           L      +++G+   I++ +G   + +  E A++ +L E   ++   +D   LE S+  +
Sbjct: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNE-AVQQILSESTPIRTSDVDYRLLEASKAGD 662

Query: 192 EQQMLQ-DARQWLNSGKIE---------------------------DVR-QARSGATALH 222
            + + Q  + Q +N   +E                           DV  + + G   LH
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722

Query: 223 VAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKL 282
            A + G+ EV  LL++ G  +NV D   +TPLH AA  G  E C +L +   D   +N+ 
Sbjct: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782

Query: 283 GQTPFDVADEGLVEHLELLQKKQNVLRSEKE 313
           G TP D+  EG  +  +LL+    +L + K+
Sbjct: 783 GNTPLDLVKEGDTDIQDLLRGDAALLDAAKK 813



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 35/106 (33%), Positives = 54/106 (50%)

Query: 77  LLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGY 136
           LL  GAD+N  +  GL  LH A    ++D+   L++    VN  D   +TPLH AA  G 
Sbjct: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915

Query: 137 LNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGI 182
             +    + HGA   + N EG+ P DLA    ++ LL++ +  + +
Sbjct: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEAL 961



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 3/111 (2%)

Query: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDM 276
           G   LH A + G++EV+ LL+  G + N +D   +TPLH AA  G  + C +L +   D 
Sbjct: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308

Query: 277 DIRNKLGQTPFDVADEGLVEHLELLQKKQNVL---RSEKETRNKLIESDLN 324
           +IRN  G++  D+AD      L    KK  +L   RS  E +   + + LN
Sbjct: 309 NIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 359



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 51/212 (24%), Positives = 74/212 (34%), Gaps = 38/212 (17%)

Query: 46  LTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLD 105
           L     P  +  DG   L     GDTD    L    A ++      L  + + C  EN+ 
Sbjct: 770 LKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI- 828

Query: 106 MVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAE 165
                     N         TPLH AA    L +AEY + HGA V   +  G +P   A 
Sbjct: 829 ----------NCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAA 878

Query: 166 EPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAA 225
                D+    +K                 +    +W                T LH AA
Sbjct: 879 SYGHVDIAALLIK-------------YNTCVNATDKW--------------AFTPLHEAA 911

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAA 257
            KG +++  LL+  G +  +++ +G TPL  A
Sbjct: 912 QKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 34/122 (27%), Positives = 61/122 (50%), Gaps = 3/122 (2%)

Query: 218 ATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD 277
           ++ LH AA  G  +V+  L+Q G  ++ +D  G  PLH A  +G  E  S+L     D +
Sbjct: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPN 276

Query: 278 IRNKLGQTPF-DVADEGLVE-HLELLQKKQNVLRSEKETRNKLIESDLNSK-IQSGFFKN 334
            R+    TP  + A +G ++  + LLQ   +      + ++ L  +D ++K + +G +K 
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336

Query: 335 KE 336
            E
Sbjct: 337 DE 338


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +G  + VR+L+  GA++N  +  G T L+ A  + +L++VKFL+EN AN N    +G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
           +TPL  A   G+ N+  + IN+G           +   N +    + L +     D+L  
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202

Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
              K G          E   L  A+  LN G   +    ++G T LH+A+ +G   ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
           L+  G ++  +  D  TPLH AA  G      IL +    +  + K G +P  +A +G  
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315

Query: 296 EHLELLQ 302
           +HL+ ++
Sbjct: 316 DHLDCVR 322



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL RGA  N  NV   T LH A    + ++ K+L++N+A VN +  +  TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
            G+ N+ +  + + A+  +  + G  P  +A      + +L  ++K+      ++K    
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
                        E  + +DA                ++   ++ V+            A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            +G T LH+AA +   EV R L+Q G   N +   G TPLH AA  G  E  ++L     
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
           + ++ NK G TP   VA EG V   ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)

Query: 6   HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
           H+  +R     +R    R  Q+  + +  LT    A R G  R  + L   G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 58  DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   +   + GD  D VR LL   A+I+ + +D LT LH A    +  + K L++  A 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
            N +   G+TPLH A    ++ + E  +  GAS+  V   G  P    S +   P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
           L     ++G     S  + E  +   AR       ++L   K +   +A+   T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
             G++ +++LL++     N+    G TPLH AA  G  E    L E         K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 286 PFDVADE-GLVEHLELLQKK 304
           P  VA + G V   ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G       LL R A  N    +GLT LH A    NLD+VK L+    + +     G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + +A   + +G S    + +G  P  LA +    +++   + KQ    
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                               +G + +    +SG T LH+ A +G+  V  +LI+ G  ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPLH A+H+G  +    L +   D++ + KLG +P    A +G  + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755

Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
                N + S+  T   +           +   +  +       +K +M + E   +  +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815

Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
           + E+E +E  S  +E  +  D   E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)

Query: 57  EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +D      A   G T+ V+ LL   A+ N     G T LH A  + +++ V  L+E  A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
                 +G+TPLH AA  G + +AE  +   A        G  P  +A      D++   
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588

Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
           + + G            L  + K+ + ++ +   Q+  S   E V+    G T LH+AA 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644

Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
           +G++E++ LL+      N+ +  G TPLH  A  G      +L +    +D   ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
             VA   G ++ ++ L + Q    ++   + KL  S L+   Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL +GA  N+  ++G T LH AC   ++ +++ L++  A+++     G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
            TPLH A+  G+L I +  +  GAS  + N + E P  +A      ++   LL+   K  
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462

Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
                ++ +++Q  L  A +  ++  ++ + +          +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
             L++           G+TPLH AA +G      +L E     +   K G TP  VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)

Query: 62  FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
           FL A  SG+ D+    L  G DINT N +GL  LH A  + ++ MV  L+     +    
Sbjct: 16  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
            +G T LH AA  G   +    +N+GA+V   + +G  P  +A +     +   LLE   
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
            Q +  E          LQ   + + +  I    + +    ALH+AA    +    +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
                +V    G+TPLH AAH+       +L      ++   + G TP  +A   G V  
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254

Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
           + LL  +     ++ ET+ K   + L+   ++G  +  E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           L R GSP     +G   L  A      +  R LL  G   N  +V G+T LH A  + + 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
           +MV  L+  +AN N  +  G TPLH  A  G++ +A+  I HG  V      G  P  +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
                  L+                           ++L   + +   + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
           A +G+++++ LL++ G   N    DG TPL  A   G      +L       +  L    
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
            R    +T  ++ D    E  EL+  K     S + +   +L++    L+  ++S     
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861

Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
               + E    +S+E E+ +KE    S        E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)

Query: 90  DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
           D  T+  +A    NLD     + N  ++N  +  G   LH A+  G++ +    ++    
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66

Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
                               K+++LE   K+                             
Sbjct: 67  --------------------KEIILETTTKK----------------------------- 77

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
                  G TALH+AA  G  EV+R L+  G  +N Q   G+TPL+ AA     E    L
Sbjct: 78  -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
            E   + ++  + G TP  VA     E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +G  + VR+L+  GA++N  +  G T L+ A  + +L++VKFL+EN AN N    +G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
           +TPL  A   G+ N+  + IN+G           +   N +    + L +     D+L  
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202

Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
              K G          E   L  A+  LN G   +    ++G T LH+A+ +G   ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
           L+  G ++  +  D  TPLH AA  G      IL +    +  + K G +P  +A +G  
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315

Query: 296 EHLELLQ 302
           +HL+ ++
Sbjct: 316 DHLDCVR 322



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL RGA  N  NV   T LH A    + ++ K+L++N+A VN +  +  TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
            G+ N+ +  + + A+  +  + G  P  +A      + +L  ++K+      ++K    
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
                        E  + +DA                ++   ++ V+            A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            +G T LH+AA +   EV R L+Q G   N +   G TPLH AA  G  E  ++L     
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
           + ++ NK G TP   VA EG V   ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)

Query: 6   HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
           H+  +R     +R    R  Q+  + +  LT    A R G  R  + L   G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 58  DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   +   + GD  D VR LL   A+I+ + +D LT LH A    +  + K L++  A 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
            N +   G+TPLH A    ++ + E  +  GAS+  V   G  P    S +   P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
           L     ++G     S  + E  +   AR       ++L   K +   +A+   T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
             G++ +++LL++     N+    G TPLH AA  G  E    L E         K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 286 PFDVADE-GLVEHLELLQKK 304
           P  VA + G V   ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G       LL R A  N    +GLT LH A    NLD+VK L+    + +     G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + +A   + +G S    + +G  P  LA +    +++   + KQ    
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                               +G + +    +SG T LH+ A +G+  V  +LI+ G  ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPLH A+H+G  +    L +   D++ + KLG +P    A +G  + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755

Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
                N + S+  T   +           +   +  +       +K +M + E   +  +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815

Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
           + E+E +E  S  +E  +  D   E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)

Query: 57  EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +D      A   G T+ V+ LL   A+ N     G T LH A  + +++ V  L+E  A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
                 +G+TPLH AA  G + +AE  +   A        G  P  +A      D++   
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588

Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
           + + G            L  + K+ + ++ +   Q+  S   E V+    G T LH+AA 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644

Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
           +G++E++ LL+      N+ +  G TPLH  A  G      +L +    +D   ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
             VA   G ++ ++ L + Q    ++   + KL  S L+   Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL +GA  N+  ++G T LH AC   ++ +++ L++  A+++     G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
            TPLH A+  G+L I +  +  GAS  + N + E P  +A      ++   LL+   K  
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462

Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
                ++ +++Q  L  A +  ++  ++ + +          +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
             L++           G+TPLH AA +G      +L E     +   K G TP  VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)

Query: 62  FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
           FL A  SG+ D+    L  G DINT N +GL  LH A  + ++ MV  L+     +    
Sbjct: 16  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
            +G T LH AA  G   +    +N+GA+V   + +G  P  +A +     +   LLE   
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
            Q +  E          LQ   + + +  I    + +    ALH+AA    +    +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
                +V    G+TPLH AAH+       +L      ++   + G TP  +A   G V  
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254

Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
           + LL  +     ++ ET+ K   + L+   ++G  +  E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           L R GSP     +G   L  A      +  R LL  G   N  +V G+T LH A  + + 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
           +MV  L+  +AN N  +  G TPLH  A  G++ +A+  I HG  V      G  P  +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
                  L+                           ++L   + +   + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
           A +G+++++ LL++ G   N    DG TPL  A   G      +L       +  L    
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
            R    +T  ++ D    E  EL+  K     S + +   +L++    L+  ++S     
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861

Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
               + E    +S+E E+ +KE    S        E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)

Query: 90  DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
           D  T+  +A    NLD     + N  ++N  +  G   LH A+  G++ +    ++    
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66

Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
                               K+++LE   K+                             
Sbjct: 67  --------------------KEIILETTTKK----------------------------- 77

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
                  G TALH+AA  G  EV+R L+  G  +N Q   G+TPL+ AA     E    L
Sbjct: 78  -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
            E   + ++  + G TP  VA     E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +G  + VR+L+  GA++N  +  G T L+ A  + +L++VKFL+EN AN N    +G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
           +TPL  A   G+ N+  + IN+G           +   N +    + L +     D+L  
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202

Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
              K G          E   L  A+  LN G   +    ++G T LH+A+ +G   ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
           L+  G ++  +  D  TPLH AA  G      IL +    +  + K G +P  +A +G  
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315

Query: 296 EHLELLQ 302
           +HL+ ++
Sbjct: 316 DHLDCVR 322



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL RGA  N  NV   T LH A    + ++ K+L++N+A VN +  +  TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
            G+ N+ +  + + A+  +  + G  P  +A      + +L  ++K+      ++K    
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
                        E  + +DA                ++   ++ V+            A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            +G T LH+AA +   EV R L+Q G   N +   G TPLH AA  G  E  ++L     
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
           + ++ NK G TP   VA EG V   ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)

Query: 6   HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
           H+  +R     +R    R  Q+  + +  LT    A R G  R  + L   G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 58  DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   +   + GD  D VR LL   A+I+ + +D LT LH A    +  + K L++  A 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
            N +   G+TPLH A    ++ + E  +  GAS+  V   G  P    S +   P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
           L     ++G     S  + E  +   AR       ++L   K +   +A+   T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
             G++ +++LL++     N+    G TPLH AA  G  E    L E         K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 286 PFDVADE-GLVEHLELLQKK 304
           P  VA + G V   ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G       LL R A  N    +GLT LH A    NLD+VK L+    + +     G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + +A   + +G S    + +G  P  LA +    +++   + KQ    
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                               +G + +    +SG T LH+ A +G+  V  +LI+ G  ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPLH A+H+G  +    L +   D++ + KLG +P    A +G  + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755

Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
                N + S+  T   +           +   +  +       +K +M + E   +  +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815

Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
           + E+E +E  S  +E  +  D   E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)

Query: 57  EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +D      A   G T+ V+ LL   A+ N     G T LH A  + +++ V  L+E  A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
                 +G+TPLH AA  G + +AE  +   A        G  P  +A      D++   
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588

Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
           + + G            L  + K+ + ++ +   Q+  S   E V+    G T LH+AA 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644

Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
           +G++E++ LL+      N+ +  G TPLH  A  G      +L +    +D   ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
             VA   G ++ ++ L + Q    ++   + KL  S L+   Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL +GA  N+  ++G T LH AC   ++ +++ L++  A+++     G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
            TPLH A+  G+L I +  +  GAS  + N + E P  +A      ++   LL+   K  
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462

Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
                ++ +++Q  L  A +  ++  ++ + +          +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
             L++           G+TPLH AA +G      +L E     +   K G TP  VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)

Query: 62  FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
           FL A  SG+ D+    L  G DINT N +GL  LH A  + ++ MV  L+     +    
Sbjct: 16  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
            +G T LH AA  G   +    +N+GA+V   + +G  P  +A +     +   LLE   
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
            Q +  E          LQ   + + +  I    + +    ALH+AA    +    +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
                +V    G+TPLH AAH+       +L      ++   + G TP  +A   G V  
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254

Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
           + LL  +     ++ ET+ K   + L+   ++G  +  E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           L R GSP     +G   L  A      +  R LL  G   N  +V G+T LH A  + + 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
           +MV  L+  +AN N  +  G TPLH  A  G++ +A+  I HG  V      G  P  +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
                  L+                           ++L   + +   + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
           A +G+++++ LL++ G   N    DG TPL  A   G      +L       +  L    
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
            R    +T  ++ D    E  EL+  K     S + +   +L++    L+  ++S     
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861

Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
               + E    +S+E E+ +KE    S        E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)

Query: 90  DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
           D  T+  +A    NLD     + N  ++N  +  G   LH A+  G++ +    ++    
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66

Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
                               K+++LE   K+                             
Sbjct: 67  --------------------KEIILETTTKK----------------------------- 77

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
                  G TALH+AA  G  EV+R L+  G  +N Q   G+TPL+ AA     E    L
Sbjct: 78  -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
            E   + ++  + G TP  VA     E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 71/247 (28%), Positives = 118/247 (47%), Gaps = 18/247 (7%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A  +G  + VR+L+  GA++N  +  G T L+ A  + +L++VKFL+EN AN N    +G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 125 WTPLHAAASCGYLNIAEYFINHGAS---------VGIVNSEGEVPSDLAEEPAMKDLLLE 175
           +TPL  A   G+ N+  + IN+G           +   N +    + L +     D+L  
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-- 202

Query: 176 QVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRL 235
              K G          E   L  A+  LN G   +    ++G T LH+A+ +G   ++RL
Sbjct: 203 --SKTGFTPLHIAAHYEN--LNVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRL 257

Query: 236 LIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLV 295
           L+  G ++  +  D  TPLH AA  G      IL +    +  + K G +P  +A +G  
Sbjct: 258 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG-- 315

Query: 296 EHLELLQ 302
           +HL+ ++
Sbjct: 316 DHLDCVR 322



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 40/270 (14%)

Query: 74  VRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAAS 133
           V+ LL RGA  N  NV   T LH A    + ++ K+L++N+A VN +  +  TPLH AA 
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 134 CGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK---- 189
            G+ N+ +  + + A+  +  + G  P  +A      + +L  ++K+      ++K    
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539

Query: 190 -----------EEEQQMLQDARQ-------------WLNSGKIEDVR-----------QA 214
                        E  + +DA                ++   ++ V+            A
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599

Query: 215 RSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALC 274
            +G T LH+AA +   EV R L+Q G   N +   G TPLH AA  G  E  ++L     
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659

Query: 275 DMDIRNKLGQTPFD-VADEGLVEHLELLQK 303
           + ++ NK G TP   VA EG V   ++L K
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 91/320 (28%), Positives = 143/320 (44%), Gaps = 26/320 (8%)

Query: 6   HLGGKRAESARMR----RAEQLR-RWRGSLTEQEPAERRGAGR--QPLTRRGSP-RVRFE 57
           H+  +R     +R    R  Q+  + +  LT    A R G  R  + L   G+P + + +
Sbjct: 244 HIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303

Query: 58  DGAVFLAACSSGD-TDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +G   +   + GD  D VR LL   A+I+ + +D LT LH A    +  + K L++  A 
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKDL 172
            N +   G+TPLH A    ++ + E  +  GAS+  V   G  P    S +   P +K+L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 173 LLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVAA 225
           L     ++G     S  + E  +   AR       ++L   K +   +A+   T LH AA
Sbjct: 424 L-----QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA 478

Query: 226 AKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQT 285
             G++ +++LL++     N+    G TPLH AA  G  E    L E         K G T
Sbjct: 479 RIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFT 538

Query: 286 PFDVADE-GLVEHLELLQKK 304
           P  VA + G V   ELL ++
Sbjct: 539 PLHVAAKYGKVRVAELLLER 558



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 80/327 (24%), Positives = 136/327 (41%), Gaps = 43/327 (13%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G       LL R A  N    +GLT LH A    NLD+VK L+    + +     G
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
           +TPLH AA    + +A   + +G S    + +G  P  LA +    +++   + KQ    
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA--- 659

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                               +G + +    +SG T LH+ A +G+  V  +LI+ G  ++
Sbjct: 660 --------------------NGNLGN----KSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPF-DVADEGLVEHLELLQK 303
                G+TPLH A+H+G  +    L +   D++ + KLG +P    A +G  + + LL K
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755

Query: 304 ---KQNVLRSEKETRNKL-----------IESDLNSKIQSGFFKNKEKMLYEEETPKSQE 349
                N + S+  T   +           +   +  +       +K +M + E   +  +
Sbjct: 756 NGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILD 815

Query: 350 M-EEENKESSSSSSEEEEGEDEASESE 375
           + E+E +E  S  +E  +  D   E E
Sbjct: 816 VSEDEGEELISFKAERRDSRDVDEEKE 842



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 19/285 (6%)

Query: 57  EDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRAN 116
           +D      A   G T+ V+ LL   A+ N     G T LH A  + +++ V  L+E  A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528

Query: 117 VNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQ 176
                 +G+TPLH AA  G + +AE  +   A        G  P  +A      D++   
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588

Query: 177 VKKQG----------IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAA 226
           + + G            L  + K+ + ++ +   Q+  S   E V+    G T LH+AA 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQ 644

Query: 227 KGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTP 286
           +G++E++ LL+      N+ +  G TPLH  A  G      +L +    +D   ++G TP
Sbjct: 645 EGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704

Query: 287 FDVADE-GLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSG 330
             VA   G ++ ++ L + Q    ++   + KL  S L+   Q G
Sbjct: 705 LHVASHYGNIKLVKFLLQHQ----ADVNAKTKLGYSPLHQAAQQG 745



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 16/237 (6%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G     + LL +GA  N+  ++G T LH AC   ++ +++ L++  A+++     G
Sbjct: 345 AAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG 404

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDL---LLEQVKKQG 181
            TPLH A+  G+L I +  +  GAS  + N + E P  +A      ++   LL+   K  
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK-- 462

Query: 182 IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQ--------ARSGATALHVAAAKGYSEVL 233
                ++ +++Q  L  A +  ++  ++ + +          +G T LH+AA +G+ E +
Sbjct: 463 ---VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETV 519

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
             L++           G+TPLH AA +G      +L E     +   K G TP  VA
Sbjct: 520 LALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/282 (26%), Positives = 122/282 (43%), Gaps = 9/282 (3%)

Query: 62  FLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
           FL A  SG+ D+    L  G DINT N +GL  LH A  + ++ MV  L+     +    
Sbjct: 16  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75

Query: 122 NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP---AMKDLLLEQVK 178
            +G T LH AA  G   +    +N+GA+V   + +G  P  +A +     +   LLE   
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135

Query: 179 KQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQ 238
            Q +  E          LQ   + + +  I    + +    ALH+AA    +    +L+Q
Sbjct: 136 NQNVATEDG-FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 239 AGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEH 297
                +V    G+TPLH AAH+       +L      ++   + G TP  +A   G V  
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIM 254

Query: 298 LELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
           + LL  +     ++ ET+ K   + L+   ++G  +  E +L
Sbjct: 255 VRLLLDR----GAQIETKTKDELTPLHCAARNGHVRISEILL 292



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 81/340 (23%), Positives = 133/340 (39%), Gaps = 38/340 (11%)

Query: 46  LTRRGSPRVRFEDGAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENL 104
           L R GSP     +G   L  A      +  R LL  G   N  +V G+T LH A  + + 
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHA 648

Query: 105 DMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLA 164
           +MV  L+  +AN N  +  G TPLH  A  G++ +A+  I HG  V      G  P  +A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 165 EEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVA 224
                  L+                           ++L   + +   + + G + LH A
Sbjct: 709 SHYGNIKLV---------------------------KFLLQHQADVNAKTKLGYSPLHQA 741

Query: 225 AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL-------AEALCDMD 277
           A +G+++++ LL++ G   N    DG TPL  A   G      +L       +  L    
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK 801

Query: 278 IRNKLGQTPFDVADEGLVEHLELLQKKQNVLRS-EKETRNKLIE--SDLNSKIQSGFFKN 334
            R    +T  ++ D    E  EL+  K     S + +   +L++    L+  ++S     
Sbjct: 802 HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPR 861

Query: 335 KEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASES 374
               + E    +S+E E+ +KE    S        E S++
Sbjct: 862 IPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDN 901



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 50/213 (23%), Positives = 77/213 (36%), Gaps = 64/213 (30%)

Query: 90  DGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGAS 149
           D  T+  +A    NLD     + N  ++N  +  G   LH A+  G++ +    ++    
Sbjct: 11  DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH---- 66

Query: 150 VGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIE 209
                               K+++LE   K+                             
Sbjct: 67  --------------------KEIILETTTKK----------------------------- 77

Query: 210 DVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
                  G TALH+AA  G  EV+R L+  G  +N Q   G+TPL+ AA     E    L
Sbjct: 78  -------GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 270 AEALCDMDIRNKLGQTPFDVA----DEGLVEHL 298
            E   + ++  + G TP  VA     E +V HL
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHL 163


>gi|56090539 dysferlin-interacting protein 1 [Homo sapiens]
          Length = 154

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 56/140 (40%), Positives = 83/140 (59%), Gaps = 8/140 (5%)

Query: 35  PAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLL-ARGADINTVNVDGLT 93
           P +RR   R+ L  R    VRF +  +FL     GD ++V + +  R   + T++  GL 
Sbjct: 13  PRQRR---RRMLADRS---VRFPNDVLFLDHIRQGDLEQVGRFIRTRKVSLATIHPSGLA 66

Query: 94  ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIV 153
           ALH+A +  NL+ VK LV+  A+++Q+D  GWTPLH A S GY +IA Y I+ GA     
Sbjct: 67  ALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISLGADRDAT 126

Query: 154 NSEGEVPSDLAEEPAMKDLL 173
           N +G++PSDL  +P  K+L+
Sbjct: 127 NDDGDLPSDLI-DPDYKELV 145



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 33/107 (30%), Positives = 51/107 (47%)

Query: 196 LQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLH 255
           L+   +++ + K+       SG  ALH A   G  E ++LL++ G +++ +D  GWTPLH
Sbjct: 43  LEQVGRFIRTRKVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLH 102

Query: 256 AAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQ 302
            A   G  +    L     D D  N  G  P D+ D    E +EL +
Sbjct: 103 IACSDGYPDIARYLISLGADRDATNDDGDLPSDLIDPDYKELVELFK 149


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 89/330 (26%), Positives = 139/330 (42%), Gaps = 37/330 (11%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A + G    V+ LL  G D++  +    TALH+A +  N +++  L+     +++QD +G
Sbjct: 49  AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            T LH A+  G+   A+  +  GA+V   N  G     LA + +                
Sbjct: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHS-------------- 154

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                       Q  R  L +G   D++   +G T LHVAA   +  ++RLL+ A   ++
Sbjct: 155 ------------QSTRVLLLAGSRADLKN-NAGDTCLHVAARYNHLSIIRLLLTAFCSVH 201

Query: 245 VQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVAD-EGLVEHLELLQK 303
            ++  G T LH AA    K+   IL EA  D  I N  GQTP + A      E   LL K
Sbjct: 202 EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261

Query: 304 KQNVL-----RSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQE----MEEEN 354
              VL     RS ++ R +L E      +        +  +   +TP S++     EE  
Sbjct: 262 APQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAR 321

Query: 355 KESSSSSSEEEEGEDEASESETEKEADKKP 384
           +E  S+S E    +D   +S  +  A   P
Sbjct: 322 EEFLSASPEPRAKDDRRRKSRPKVSAFSDP 351


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 134/598 (22%), Positives = 237/598 (39%), Gaps = 99/598 (16%)

Query: 63   LAACSSGDTDEVRKLLARGADINT-VNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
            + A  +G    V+ LL  G+DIN  +  +  TAL  AC     ++V  L++ +ANV  + 
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254

Query: 122  NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQG 181
              G TPL  AAS GY  +    ++ GA V           +    P+ +D  L     +G
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADV-----------NAPPVPSSRDTALTIAADKG 1303

Query: 182  IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGY 241
                           +     ++ G   DVR  + G T L +A+  G+ +V++LL+QAG 
Sbjct: 1304 -------------HYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLVQAGA 1349

Query: 242  ELNVQDYDGWTPLHAAAHWG--------VKEA--------CSILAEALCDMDIRNKLGQ- 284
            +++  D    TPL +A   G        VKE         C      + D ++  K  Q 
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQC 1409

Query: 285  --TPFDVADEGLVE---HLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
              T     D+   E   +  +L K+ ++ +S +E+R + + +    + +    K K+K  
Sbjct: 1410 VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE----KRKKK-- 1463

Query: 340  YEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN---SESK 396
             +EE  + QE +EENK   +S   E+E E+E ++ + E+E   +P +    +    S + 
Sbjct: 1464 -KEEQKRKQEEDEENKPKENSELPEDEDEEE-NDEDVEQEVPIEPPSATTTTTIGISATS 1521

Query: 397  SSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVAN 456
            ++ T        N  +  S  R      NK  + K+  P++    L     H  L++   
Sbjct: 1522 ATFTNVFGKKRANVVTTPSTNR-----KNKKNKTKETPPTA---HLILPEQHMSLAQQKA 1573

Query: 457  SREPI--RDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKE-- 512
             +  I    RG     +S S       DN D    N    S    ++LN   D+   +  
Sbjct: 1574 DKNKINGEPRGGGAGGNSDS-------DNLDSTDCNSESSSGGKSQELNFVMDVNSSKYP 1626

Query: 513  -----NRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTA 567
                 ++E   +   S + TR       +G   P +++ S Y +  L  +    + + T+
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTR------LEGEVTPNSLSTS-YKTVSLPLSSPNIKLNLTS 1679

Query: 568  EKTADNVSSSTPLCVITNRPLPSTAN---------GVTATPVLSITGTDSSVEAREKR 616
             K            V  ++ L   A+         G   T +  +TG    V+ ++ +
Sbjct: 1680 PKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDK 1737



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 70/216 (32%), Positives = 109/216 (50%), Gaps = 11/216 (5%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           +AA S G  D V+ LL   AD+N+ +  G TAL  AC    +D+VK L+   AN+   + 
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE-GEVPSDLAEEPAMKDLLLEQVKKQG 181
            G TPL  AAS G++ +A   ++HGA +   ++E  E    LA      D ++  + + G
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD-MVRFLLEAG 395

Query: 182 IDLEQSRKEEEQQMLQD--------ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVL 233
            D E    E    +++         AR  L+SG   ++  A S  + L +AA  G+ E+ 
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM-PADSFESPLTLAACGGHVELA 454

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
            LLI+ G  L   + +G+TPL  AA  G +E  ++L
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 100/423 (23%), Positives = 172/423 (40%), Gaps = 56/423 (13%)

Query: 65   ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE- 123
            ACS G  + V  LLARGA+    NV   T L  A     ++++K L+   A +N +    
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188

Query: 124  -GWTPLHAAASCGYLNIAEYFINHGASV--------------GIVNSEGEVPSDLAEEPA 168
             G +PL  AA  G++   +  ++ G+ +                     EV S L +  A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248

Query: 169  MKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKG 228
              +   +      ++       E  ++L D    +N+  +   R      TAL +AA KG
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-----TALTIAADKG 1303

Query: 229  YSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFD 288
            + +   LLI  G  ++V++  G TPL  A++ G  +   +L +A  D+D  +    TP  
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363

Query: 289  VA-DEGLVEHLELLQKKQNVLRSEKETR---------------NKLIESDLNSKIQSGFF 332
             A  +G V+ ++ L K+ N   S+ E                 ++ +E+ + +K Q    
Sbjct: 1364 SAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAE 1423

Query: 333  KNKEK--MLYEEETPKSQE---------MEEENKESSSSSSEEEEGEDEASESETEKEAD 381
             NK    +L E +  KS+E           E+ KE      EE++ + E  E    KE  
Sbjct: 1424 ANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS 1483

Query: 382  KKPEAFVNHSNSESKSSITEQIP-----APAQNTFSASSARRFSSGLFNKPEEPKDESPS 436
            + PE   +    E+   + +++P     A    T   S+     + +F K       +PS
Sbjct: 1484 ELPE---DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPS 1540

Query: 437  SWR 439
            + R
Sbjct: 1541 TNR 1543



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 82/295 (27%), Positives = 131/295 (44%), Gaps = 45/295 (15%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           ACS GD + VRKLL  G  +N    +G + L  AC     ++ + L+   ANV  + N+G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 125 -WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
             TPL AA+S GYL+I +  + H A V   ++ G      A      D +++ +  +G +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD-IVKVLLNEGAN 330

Query: 184 LEQSRKE--------------EEQQMLQDARQWLNS----------------GKIEDVR- 212
           +E   +               E  ++L D    +N+                G ++ VR 
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390

Query: 213 QARSGA----------TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGV 262
              +GA          TAL  A   G+ EV RLL+ +G ++N+      +PL  AA  G 
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450

Query: 263 KEACSILAEALCDMDIRNKLGQTP-FDVADEGLVEHLE-LLQKKQNVLRSEKETR 315
            E  ++L E   +++  N  G TP  + A EG  E +  LL +  N+    +ET+
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 20/211 (9%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + AC  G  +  R LL  GA +N       + L  A    ++++   L+E  AN+ + ++
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA-------MKDLLLE 175
           EG+TPL  AA  G+  +    +  GA+   +N++ E   + A   A       + D L+ 
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLI- 525

Query: 176 QVKKQGIDLEQS-----RKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
              K G D+E        +  ++  L+  +  L SG       A +G TAL  A   G++
Sbjct: 526 ---KAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHT 581

Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
           +V  +L+QAG +L  +   G TPL  AA  G
Sbjct: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAG 612



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 12/212 (5%)

Query: 93   TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
            TAL  AC   + ++V  L+   A +  +D +G+TPL  AA+ G++ + E  ++ G  +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 153  VNSE-GEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA--------RQWL 203
             +    + P  LA     ++ +++ +  +G + E     +   +   A        +  L
Sbjct: 1117 QSERTKDTPLSLACSGGRQE-VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 204  NSG-KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ-DYDGWTPLHAAAHWG 261
            N+G +I     ++ G + L +AA  G+   ++LL+  G ++N Q + +  T L  A   G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 262  VKEACSILAEALCDMDIRNKLGQTPFDVADEG 293
              E  S+L +   +++ R K G TP   A  G
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 54/202 (26%), Positives = 93/202 (46%), Gaps = 28/202 (13%)

Query: 72  DEVRKLLARGADINTVNVDGLT--ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLH 129
           DE    L R    N+ N   +   +L +AC D +++ V+ L++   +VN+   EG + L 
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243

Query: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK 189
            A S GY  +A+  +   A+V    ++G++   +A   A     L+ VK           
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA---ASSGGYLDIVK----------- 289

Query: 190 EEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYD 249
                +L DA   +NS       Q+ +G TAL  A A G+ +++++L+  G  +   + +
Sbjct: 290 ---LLLLHDAD--VNS-------QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 250 GWTPLHAAAHWGVKEACSILAE 271
           G TPL  AA  G  E   +L +
Sbjct: 338 GHTPLMEAASAGHVEVARVLLD 359



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 29/88 (32%), Positives = 48/88 (54%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + A   G  + V+ LLA GA+++     G TAL  AC + + D+   L++  A++  +  
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASV 150
            G TPL  AA  G+L   ++ I+ GA+V
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANV 627



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 1/85 (1%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD-NE 123
           AC +G TD    LL  GAD+   +  G T L +A    +L  V+FL+   ANVN+   N 
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634

Query: 124 GWTPLHAAASCGYLNIAEYFINHGA 148
             T +  A + G+L + E  + HGA
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGA 659



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 92/413 (22%), Positives = 151/413 (36%), Gaps = 94/413 (22%)

Query: 58   DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
            D A+ +AA   G       L+ RGA I+  N  G T L  A    + D+V+ LV+  A+V
Sbjct: 1293 DTALTIAA-DKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351

Query: 118  NQQDNEGWTPLHAAASCGYLNIAEYFIN---------------------------HGASV 150
            +  DN   TPL +A   G++ + +Y +                            H    
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVE 1411

Query: 151  GIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIED 210
             IV ++ +     AE      +LL++     +DLE+SR+E  +Q L   R+     + + 
Sbjct: 1412 TIVKAKDQ---QAAEANKNASILLKE-----LDLEKSREESRKQALAAKREKRKEKRKKK 1463

Query: 211  VRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAH----------- 259
              + +           K  SE   L      E N +D +   P+   +            
Sbjct: 1464 KEEQKRKQEEDEENKPKENSE---LPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISAT 1520

Query: 260  -------WGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK 312
                   +G K A  +   +    + +NK  +TP         +H+ L Q+K +  +   
Sbjct: 1521 SATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKING 1580

Query: 313  ETR----------NKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS-- 360
            E R          + L  +D NS+  SG               KSQE+      +SS   
Sbjct: 1581 EPRGGGAGGNSDSDNLDSTDCNSESSSG--------------GKSQELNFVMDVNSSKYP 1626

Query: 361  ----SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQN 409
                 S+EE+     S+++T  E +  P       NS S S  T  +P  + N
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTRLEGEVTP-------NSLSTSYKTVSLPLSSPN 1672



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 21/60 (35%), Positives = 29/60 (48%)

Query: 58  DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
           D  V   AC+ G    V  LLA GAD      DG T L +A    + ++V +L++   NV
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 134/598 (22%), Positives = 237/598 (39%), Gaps = 99/598 (16%)

Query: 63   LAACSSGDTDEVRKLLARGADINT-VNVDGLTALHQACIDENLDMVKFLVENRANVNQQD 121
            + A  +G    V+ LL  G+DIN  +  +  TAL  AC     ++V  L++ +ANV  + 
Sbjct: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254

Query: 122  NEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQG 181
              G TPL  AAS GY  +    ++ GA V           +    P+ +D  L     +G
Sbjct: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADV-----------NAPPVPSSRDTALTIAADKG 1303

Query: 182  IDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGY 241
                           +     ++ G   DVR  + G T L +A+  G+ +V++LL+QAG 
Sbjct: 1304 -------------HYKFCELLIHRGAHIDVRN-KKGNTPLWLASNGGHFDVVQLLVQAGA 1349

Query: 242  ELNVQDYDGWTPLHAAAHWG--------VKEA--------CSILAEALCDMDIRNKLGQ- 284
            +++  D    TPL +A   G        VKE         C      + D ++  K  Q 
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQC 1409

Query: 285  --TPFDVADEGLVE---HLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKML 339
              T     D+   E   +  +L K+ ++ +S +E+R + + +    + +    K K+K  
Sbjct: 1410 VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE----KRKKK-- 1463

Query: 340  YEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSN---SESK 396
             +EE  + QE +EENK   +S   E+E E+E ++ + E+E   +P +    +    S + 
Sbjct: 1464 -KEEQKRKQEEDEENKPKENSELPEDEDEEE-NDEDVEQEVPIEPPSATTTTTIGISATS 1521

Query: 397  SSITEQIPAPAQNTFSASSARRFSSGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVAN 456
            ++ T        N  +  S  R      NK  + K+  P++    L     H  L++   
Sbjct: 1522 ATFTNVFGKKRANVVTTPSTNR-----KNKKNKTKETPPTA---HLILPEQHMSLAQQKA 1573

Query: 457  SREPI--RDRGSSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKE-- 512
             +  I    RG     +S S       DN D    N    S    ++LN   D+   +  
Sbjct: 1574 DKNKINGEPRGGGAGGNSDS-------DNLDSTDCNSESSSGGKSQELNFVMDVNSSKYP 1626

Query: 513  -----NRESAVNLVRSGSYTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTA 567
                 ++E   +   S + TR       +G   P +++ S Y +  L  +    + + T+
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTR------LEGEVTPNSLSTS-YKTVSLPLSSPNIKLNLTS 1679

Query: 568  EKTADNVSSSTPLCVITNRPLPSTAN---------GVTATPVLSITGTDSSVEAREKR 616
             K            V  ++ L   A+         G   T +  +TG    V+ ++ +
Sbjct: 1680 PKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDK 1737



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 70/216 (32%), Positives = 109/216 (50%), Gaps = 11/216 (5%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           +AA S G  D V+ LL   AD+N+ +  G TAL  AC    +D+VK L+   AN+   + 
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSE-GEVPSDLAEEPAMKDLLLEQVKKQG 181
            G TPL  AAS G++ +A   ++HGA +   ++E  E    LA      D ++  + + G
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD-MVRFLLEAG 395

Query: 182 IDLEQSRKEEEQQMLQD--------ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVL 233
            D E    E    +++         AR  L+SG   ++  A S  + L +AA  G+ E+ 
Sbjct: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM-PADSFESPLTLAACGGHVELA 454

Query: 234 RLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSIL 269
            LLI+ G  L   + +G+TPL  AA  G +E  ++L
Sbjct: 455 ALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 100/423 (23%), Positives = 172/423 (40%), Gaps = 56/423 (13%)

Query: 65   ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNE- 123
            ACS G  + V  LLARGA+    NV   T L  A     ++++K L+   A +N +    
Sbjct: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188

Query: 124  -GWTPLHAAASCGYLNIAEYFINHGASV--------------GIVNSEGEVPSDLAEEPA 168
             G +PL  AA  G++   +  ++ G+ +                     EV S L +  A
Sbjct: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248

Query: 169  MKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKG 228
              +   +      ++       E  ++L D    +N+  +   R      TAL +AA KG
Sbjct: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-----TALTIAADKG 1303

Query: 229  YSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFD 288
            + +   LLI  G  ++V++  G TPL  A++ G  +   +L +A  D+D  +    TP  
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363

Query: 289  VA-DEGLVEHLELLQKKQNVLRSEKETR---------------NKLIESDLNSKIQSGFF 332
             A  +G V+ ++ L K+ N   S+ E                 ++ +E+ + +K Q    
Sbjct: 1364 SAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAE 1423

Query: 333  KNKEK--MLYEEETPKSQE---------MEEENKESSSSSSEEEEGEDEASESETEKEAD 381
             NK    +L E +  KS+E           E+ KE      EE++ + E  E    KE  
Sbjct: 1424 ANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS 1483

Query: 382  KKPEAFVNHSNSESKSSITEQIP-----APAQNTFSASSARRFSSGLFNKPEEPKDESPS 436
            + PE   +    E+   + +++P     A    T   S+     + +F K       +PS
Sbjct: 1484 ELPE---DEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPS 1540

Query: 437  SWR 439
            + R
Sbjct: 1541 TNR 1543



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 82/295 (27%), Positives = 131/295 (44%), Gaps = 45/295 (15%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           ACS GD + VRKLL  G  +N    +G + L  AC     ++ + L+   ANV  + N+G
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

Query: 125 -WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGID 183
             TPL AA+S GYL+I +  + H A V   ++ G      A      D +++ +  +G +
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD-IVKVLLNEGAN 330

Query: 184 LEQSRKE--------------EEQQMLQDARQWLNS----------------GKIEDVR- 212
           +E   +               E  ++L D    +N+                G ++ VR 
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390

Query: 213 QARSGA----------TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGV 262
              +GA          TAL  A   G+ EV RLL+ +G ++N+      +PL  AA  G 
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450

Query: 263 KEACSILAEALCDMDIRNKLGQTP-FDVADEGLVEHLE-LLQKKQNVLRSEKETR 315
            E  ++L E   +++  N  G TP  + A EG  E +  LL +  N+    +ET+
Sbjct: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 20/211 (9%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + AC  G  +  R LL  GA +N       + L  A    ++++   L+E  AN+ + ++
Sbjct: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPA-------MKDLLLE 175
           EG+TPL  AA  G+  +    +  GA+   +N++ E   + A   A       + D L+ 
Sbjct: 470 EGYTPLMEAAREGHEEMVALLLAQGAN---INAQTEETQETALTLACCGGFSEVADFLI- 525

Query: 176 QVKKQGIDLEQS-----RKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
              K G D+E        +  ++  L+  +  L SG       A +G TAL  A   G++
Sbjct: 526 ---KAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA-TGDTALTYACENGHT 581

Query: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWG 261
           +V  +L+QAG +L  +   G TPL  AA  G
Sbjct: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAG 612



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 12/212 (5%)

Query: 93   TALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGI 152
            TAL  AC   + ++V  L+   A +  +D +G+TPL  AA+ G++ + E  ++ G  +  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 153  VNSE-GEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA--------RQWL 203
             +    + P  LA     ++ +++ +  +G + E     +   +   A        +  L
Sbjct: 1117 QSERTKDTPLSLACSGGRQE-VVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 204  NSG-KIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ-DYDGWTPLHAAAHWG 261
            N+G +I     ++ G + L +AA  G+   ++LL+  G ++N Q + +  T L  A   G
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235

Query: 262  VKEACSILAEALCDMDIRNKLGQTPFDVADEG 293
              E  S+L +   +++ R K G TP   A  G
Sbjct: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 54/202 (26%), Positives = 93/202 (46%), Gaps = 28/202 (13%)

Query: 72  DEVRKLLARGADINTVNVDGLT--ALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLH 129
           DE    L R    N+ N   +   +L +AC D +++ V+ L++   +VN+   EG + L 
Sbjct: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243

Query: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRK 189
            A S GY  +A+  +   A+V    ++G++   +A   A     L+ VK           
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA---ASSGGYLDIVK----------- 289

Query: 190 EEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYD 249
                +L DA   +NS       Q+ +G TAL  A A G+ +++++L+  G  +   + +
Sbjct: 290 ---LLLLHDAD--VNS-------QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNEN 337

Query: 250 GWTPLHAAAHWGVKEACSILAE 271
           G TPL  AA  G  E   +L +
Sbjct: 338 GHTPLMEAASAGHVEVARVLLD 359



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 29/88 (32%), Positives = 48/88 (54%)

Query: 63  LAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDN 122
           + A   G  + V+ LLA GA+++     G TAL  AC + + D+   L++  A++  +  
Sbjct: 540 MEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE 599

Query: 123 EGWTPLHAAASCGYLNIAEYFINHGASV 150
            G TPL  AA  G+L   ++ I+ GA+V
Sbjct: 600 GGRTPLMKAARAGHLCTVQFLISKGANV 627



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 1/85 (1%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQD-NE 123
           AC +G TD    LL  GAD+   +  G T L +A    +L  V+FL+   ANVN+   N 
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634

Query: 124 GWTPLHAAASCGYLNIAEYFINHGA 148
             T +  A + G+L + E  + HGA
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGA 659



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 92/413 (22%), Positives = 151/413 (36%), Gaps = 94/413 (22%)

Query: 58   DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
            D A+ +AA   G       L+ RGA I+  N  G T L  A    + D+V+ LV+  A+V
Sbjct: 1293 DTALTIAA-DKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351

Query: 118  NQQDNEGWTPLHAAASCGYLNIAEYFIN---------------------------HGASV 150
            +  DN   TPL +A   G++ + +Y +                            H    
Sbjct: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVE 1411

Query: 151  GIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIED 210
             IV ++ +     AE      +LL++     +DLE+SR+E  +Q L   R+     + + 
Sbjct: 1412 TIVKAKDQ---QAAEANKNASILLKE-----LDLEKSREESRKQALAAKREKRKEKRKKK 1463

Query: 211  VRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAH----------- 259
              + +           K  SE   L      E N +D +   P+   +            
Sbjct: 1464 KEEQKRKQEEDEENKPKENSE---LPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISAT 1520

Query: 260  -------WGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEK 312
                   +G K A  +   +    + +NK  +TP         +H+ L Q+K +  +   
Sbjct: 1521 SATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKING 1580

Query: 313  ETR----------NKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS-- 360
            E R          + L  +D NS+  SG               KSQE+      +SS   
Sbjct: 1581 EPRGGGAGGNSDSDNLDSTDCNSESSSG--------------GKSQELNFVMDVNSSKYP 1626

Query: 361  ----SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQN 409
                 S+EE+     S+++T  E +  P       NS S S  T  +P  + N
Sbjct: 1627 SLLLHSQEEKTSTATSKTQTRLEGEVTP-------NSLSTSYKTVSLPLSSPN 1672



 Score = 31.6 bits (70), Expect = 3.9
 Identities = 21/60 (35%), Positives = 29/60 (48%)

Query: 58  DGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANV 117
           D  V   AC+ G    V  LLA GAD      DG T L +A    + ++V +L++   NV
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 66/224 (29%), Positives = 113/224 (50%), Gaps = 15/224 (6%)

Query: 83  DINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEY 142
           ++N  + DG +ALH A ++ N +++  L+E +A V+ +DN+G  PLH AA  G     + 
Sbjct: 41  NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100

Query: 143 FINHGASVGIVNSEGEVPSDLAEEPAMKDL--LLEQVKKQGIDLEQSRKEEEQQMLQDAR 200
            +  G++V I + EG +P  LA +    D+  +L Q +     ++ S K       +  R
Sbjct: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160

Query: 201 -----QWLNSGKIEDVRQAR-------SGATALHVAAAKGYSEVLRLLIQAGYELNVQDY 248
                  L+S     + + R       +G + LH+AA  G+ +++RLL+QAG ++N Q  
Sbjct: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220

Query: 249 DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADE 292
            G T LH AA  G  E   +L ++  +  +RN   QT  D+  +
Sbjct: 221 SG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQ 263



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 57/219 (26%), Positives = 97/219 (44%), Gaps = 24/219 (10%)

Query: 65  ACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEG 124
           A   G  + ++ +L  G+ +N  + +G   LH A    + D+ + L+++++N    DN G
Sbjct: 89  AAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSG 148

Query: 125 WTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDL 184
            TPL  A   G + + +  ++      ++      P D A +P     L    K   ID+
Sbjct: 149 KTPLDLACEFGRVGVVQLLLSSNMCAALLEPR---PGD-ATDPNGTSPLHLAAKNGHIDI 204

Query: 185 EQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELN 244
                          R  L +G I+  RQ +SG TALH AA  G +EV+RLL+ +G   +
Sbjct: 205 --------------IRLLLQAG-IDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248

Query: 245 VQDYDGWTPLHAAAHWGVKEAC----SILAEALCDMDIR 279
           V++    T L     +   +A      +L EA   + +R
Sbjct: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.122    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,297,366
Number of Sequences: 37866
Number of extensions: 1894622
Number of successful extensions: 35508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 842
Number of HSP's successfully gapped in prelim test: 1345
Number of HSP's that attempted gapping in prelim test: 14097
Number of HSP's gapped (non-prelim): 13744
length of query: 998
length of database: 18,247,518
effective HSP length: 112
effective length of query: 886
effective length of database: 14,006,526
effective search space: 12409782036
effective search space used: 12409782036
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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