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Search of human proteins with 9966787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 1309 0.0
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 395 e-110
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 395 e-110
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 390 e-108
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 370 e-102
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 346 3e-95
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 177 2e-44
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 78 3e-14
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 76 1e-13
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 69 1e-11
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 69 1e-11
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 69 1e-11
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 69 1e-11
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 59 2e-08
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 59 2e-08
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 59 2e-08
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 59 2e-08
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 54 5e-07
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 54 5e-07
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 35 0.22
gi|149999615 variable charge, X-linked 3B [Homo sapiens] 35 0.22
gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform... 34 0.49
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 34 0.49
gi|134288865 solute carrier family 4, sodium bicarbonate cotrans... 34 0.49
gi|157266307 aquaporin 9 [Homo sapiens] 33 1.1
gi|66932943 variable charge, X chromosome [Homo sapiens] 33 1.1
gi|48762947 variable charge, X-linked 3A [Homo sapiens] 32 1.4
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 32 1.4
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 32 1.4
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 32 2.4
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 1309 bits (3388), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS 60
MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS
Sbjct: 1 MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS 60
Query: 61 ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY 120
ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY
Sbjct: 61 ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY 120
Query: 121 PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM 180
PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM
Sbjct: 121 PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM 180
Query: 181 AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR 240
AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR
Sbjct: 181 AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR 240
Query: 241 DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV 300
DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV
Sbjct: 241 DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV 300
Query: 301 KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE 360
KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE
Sbjct: 301 KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE 360
Query: 361 LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST 420
LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST
Sbjct: 361 LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST 420
Query: 421 DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV 480
DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV
Sbjct: 421 DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV 480
Query: 481 FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL 540
FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL
Sbjct: 481 FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL 540
Query: 541 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS 600
AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS
Sbjct: 541 AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS 600
Query: 601 NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS 660
NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS
Sbjct: 601 NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS 660
Query: 661 I 661
I
Sbjct: 661 I 661
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 395 bits (1016), Expect = e-110
Identities = 223/571 (39%), Positives = 338/571 (59%), Gaps = 42/571 (7%)
Query: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161
P++ ++N TD A ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 3 PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 62
Query: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221
I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 63 EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 122
Query: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281
+C LF+ +++ LTWW + RD +Y + +I+LI+F D I+WWE L+L+ Y Y++ MK
Sbjct: 123 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 182
Query: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARD-----KDEPTLP----AKPRL 328
+NV+++ + K + N N V ++ A D D+P++P K +
Sbjct: 183 YNVKMQAFFTVKQKSIANGNPV--------NSELEAGNDFYDGSYDDPSVPLLGQVKEKP 234
Query: 329 QRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHK 388
Q G + + + +M +S + E G ++ + R R + I+
Sbjct: 235 QYGKNPVVMVDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII-- 283
Query: 389 IAKKKCHVDENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGA 446
++E +R +AN V L N ++E P + +P QN +
Sbjct: 284 -------INERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 336
Query: 447 EAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGS 506
+ E D + P +V ++ +P++F L +T+P+ KP KFF +TF +
Sbjct: 337 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 396
Query: 507 ITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 566
WIAVFSY+MVW +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS
Sbjct: 397 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 456
Query: 567 SSVGSNIFDITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCK 625
+++GSN+FDI VGL +PW L T++ + V ++S GL ++VLL + +L I L K
Sbjct: 457 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 516
Query: 626 WRMNKILGFIMFGLYFVFLVVSVLLEDRILT 656
WR+++ LG + LY +FL S+++E + T
Sbjct: 517 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFT 547
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 395 bits (1016), Expect = e-110
Identities = 223/571 (39%), Positives = 338/571 (59%), Gaps = 42/571 (7%)
Query: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161
P++ ++N TD A ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 50 PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 109
Query: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221
I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 110 EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 169
Query: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281
+C LF+ +++ LTWW + RD +Y + +I+LI+F D I+WWE L+L+ Y Y++ MK
Sbjct: 170 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 229
Query: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARD-----KDEPTLP----AKPRL 328
+NV+++ + K + N N V ++ A D D+P++P K +
Sbjct: 230 YNVKMQAFFTVKQKSIANGNPV--------NSELEAGNDFYDGSYDDPSVPLLGQVKEKP 281
Query: 329 QRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHK 388
Q G + + + +M +S + E G ++ + R R + I+
Sbjct: 282 QYGKNPVVMVDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII-- 330
Query: 389 IAKKKCHVDENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGA 446
++E +R +AN V L N ++E P + +P QN +
Sbjct: 331 -------INERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 383
Query: 447 EAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGS 506
+ E D + P +V ++ +P++F L +T+P+ KP KFF +TF +
Sbjct: 384 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 443
Query: 507 ITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 566
WIAVFSY+MVW +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS
Sbjct: 444 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 503
Query: 567 SSVGSNIFDITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCK 625
+++GSN+FDI VGL +PW L T++ + V ++S GL ++VLL + +L I L K
Sbjct: 504 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 563
Query: 626 WRMNKILGFIMFGLYFVFLVVSVLLEDRILT 656
WR+++ LG + LY +FL S+++E + T
Sbjct: 564 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFT 594
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 390 bits (1003), Expect = e-108
Identities = 219/562 (38%), Positives = 332/562 (59%), Gaps = 43/562 (7%)
Query: 102 PLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSL 161
P++ ++N TD A ++P D+FS +ER+ GA++LH++G +YMF ALAIVCD+FFVPSL
Sbjct: 50 PVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSL 109
Query: 162 TVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIG 221
I E+L +S+DVAGATFMAAG S PELF S+IGVFI H +VG+GTIVGSAVFNIL +IG
Sbjct: 110 EKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIG 169
Query: 222 MCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMK 281
+C LF+ +++ LTWW + RD +Y + +I+LI+F D I+WWE L+L+ Y Y++ MK
Sbjct: 170 VCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMK 229
Query: 282 FNVQVEKWV----KQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASL 337
+NV+++ + K + N N V ++ A ++K Q G + +
Sbjct: 230 YNVKMQAFFTVKQKSIANGNPV--------NSELEAVKEKP----------QYGKNPVVM 271
Query: 338 HNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVD 397
+ +M +S + E G ++ + R R + I+ ++
Sbjct: 272 VDEIMSSSPPKFTF-------PEAGL--RIMITNKFGPRTRLRMASRII---------IN 313
Query: 398 ENERQNGAANHVEKIELPNSTSTDVE--MTPSSDASEPVQNGNLSHNIEGAEAQTADEEE 455
E +R +AN V L N ++E P + +P QN + + E
Sbjct: 314 ERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEA 373
Query: 456 DQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSY 515
D + P +V ++ +P++F L +T+P+ KP KFF +TF + WIAVFSY
Sbjct: 374 DFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSY 433
Query: 516 LMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFD 575
+MVW +G T+GI + IMG+T LAAGTS+PD + S+IVAR+GLGDMAVS+++GSN+FD
Sbjct: 434 IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFD 493
Query: 576 ITVGLPLPWLLYTVIHRF-QPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGF 634
I VGL +PW L T++ + V ++S GL ++VLL + +L I L KWR+++ LG
Sbjct: 494 ILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGV 553
Query: 635 IMFGLYFVFLVVSVLLEDRILT 656
+ LY +FL S+++E + T
Sbjct: 554 YVLVLYAIFLCFSIMIEFNVFT 575
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 370 bits (949), Expect = e-102
Identities = 217/559 (38%), Positives = 321/559 (57%), Gaps = 19/559 (3%)
Query: 109 SENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKL 168
S+N T+ A ++P DIF+ E+RR+GA++LHV+ IYMF ALAIVCD+FFVPSL I E+L
Sbjct: 84 SKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERL 143
Query: 169 GISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSR 228
+S+DVAGATFMAAG SAPELFTS+IGVFI +VG+GTIVGSAVFNIL +IG+C LF+
Sbjct: 144 HLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
Query: 229 EILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEK 288
+++ L+ W L RD +Y + +I LI+F D + WWESL+L+ Y Y+V MK+N + +
Sbjct: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQ 263
Query: 289 -WVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGS--------SASLHN 339
+ ++ +V A A+ S+ D L K R S SA H
Sbjct: 264 CFERRTKGAGNMVNGLANNAEIDDSSNCDA-TVVLLKKANFHRKASVIMVDELLSAYPHQ 322
Query: 340 SLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVD-E 398
+ ++MI + P L ++ + E R + + ++ + +
Sbjct: 323 LSFSEAGLRIMITSHFPPKTRLSMASRM----LINERQRLINSRAYTNGESEVAIKIPIK 378
Query: 399 NERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQP 458
+ +NG N T D + ++A +N N + + E + D++E
Sbjct: 379 HTVENGTGPSSAPDRGVNGTRRDDVV---AEAGNETENENEDNENDEEEEEDEDDDEGPY 435
Query: 459 LSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMV 518
PS + V + +P+ F L+ T+P+ KP K+F +TF S WIA FSY+MV
Sbjct: 436 TPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMV 495
Query: 519 WWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV 578
W +G T+GI + IMG+T LAAGTS+PD + S+IVAR+G+GDMAVS+S+GSN+FDI +
Sbjct: 496 WMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILI 555
Query: 579 GLPLPWLLYTV-IHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMF 637
GL LPW L T+ + + ++S GL ++ LL + + + L KW+++K LG
Sbjct: 556 GLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCL 615
Query: 638 GLYFVFLVVSVLLEDRILT 656
LY VFL S++ E + T
Sbjct: 616 LLYGVFLCFSIMTEFNVFT 634
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 346 bits (888), Expect = 3e-95
Identities = 192/351 (54%), Positives = 241/351 (68%), Gaps = 17/351 (4%)
Query: 115 HAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDV 174
H +G+YP D+FS+EERR+G ++LHV GM+Y+F+ALAIVCDE+FVP+L VIT+KL IS+DV
Sbjct: 435 HPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDV 494
Query: 175 AGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLT 234
AGATFMAAGGSAPELFTSLIGVFI+HSNVGIGTIVGSAVFNILFVIG C+LFSREILNLT
Sbjct: 495 AGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLT 554
Query: 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMI 294
WWPLFRDVSFYI+DLIMLI+FFLD++I WWESLLLL AY YV MK+N +E WVK+ +
Sbjct: 555 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQL 614
Query: 295 NRNKVVKVTAPEAQAKP---SAARD--KDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQL 349
+R V KV A E +KP + A D +D L L RG SS SLHNS +R++I+QL
Sbjct: 615 SRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQL 674
Query: 350 MIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHV 409
M+H+LDPL E K K +++ + R + + AK + +E E A V
Sbjct: 675 MLHSLDPLREV--RLAKEKEEESLNQGARAQPQ-------AKAESKPEEEEPAKLPAVTV 725
Query: 410 EKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLS 460
+P+ E + E V + + G E +TA E E + S
Sbjct: 726 TPAPVPDIKGDQKE---NPGGQEDVAEAESTGEMPGEEGETAGEGETEEKS 773
Score = 343 bits (881), Expect = 2e-94
Identities = 175/262 (66%), Positives = 203/262 (77%), Gaps = 3/262 (1%)
Query: 403 NGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEE---DQPL 459
+G A + EK S + + E + E E + +EEE ++PL
Sbjct: 838 HGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPL 897
Query: 460 SLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVW 519
SL WP +KQ +L + PIVFPLW+T+PDVR+ SRKFF TF GSI WIA+FSYLMVW
Sbjct: 898 SLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVW 957
Query: 520 WAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVG 579
WAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVG
Sbjct: 958 WAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVG 1017
Query: 580 LPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGL 639
LP+PWLL+++I+ QPV VSSNGLFCAIVLLF+MLLFVI SIA CKWRMNKILGF MF L
Sbjct: 1018 LPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLL 1077
Query: 640 YFVFLVVSVLLEDRILTCPVSI 661
YFVFL++SV+LEDRI++CPVS+
Sbjct: 1078 YFVFLIISVMLEDRIISCPVSV 1099
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/128 (28%), Positives = 66/128 (51%), Gaps = 4/128 (3%)
Query: 164 ITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMC 223
+ E +GIS+++ G T +AAG S P+L TS+I ++ + + VGS +F+I + +
Sbjct: 962 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVP 1021
Query: 224 ALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVI---MW-WESLLLLTAYFCYVVF 279
L I L P+ + F + L+ L++ F+ + I W +L T + Y VF
Sbjct: 1022 WLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVF 1081
Query: 280 MKFNVQVE 287
+ +V +E
Sbjct: 1082 LIISVMLE 1089
Score = 39.7 bits (91), Expect = 0.009
Identities = 19/53 (35%), Positives = 33/53 (62%)
Query: 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDI 576
+ + + ISE++ G T +AAG S P+L TS+I ++ + + VGS +F+I
Sbjct: 484 ITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNI 536
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 177 bits (450), Expect = 2e-44
Identities = 81/192 (42%), Positives = 125/192 (65%)
Query: 99 PQPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFV 158
PQ G S ++P+ F+ +ERR G II++ + ++YMF+A++IVCDE+F+
Sbjct: 33 PQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFL 92
Query: 159 PSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILF 218
PSL +I+E LG+S DVAG TFMAAG SAPEL T+ +GVFI ++GI TI+GSA++N+L
Sbjct: 93 PSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLG 152
Query: 219 VIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVV 278
+ C L S + L+ WPLFRD + Y + ++ DN + W+E LLL Y YV+
Sbjct: 153 ICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVL 212
Query: 279 FMKFNVQVEKWV 290
+ F++++ +++
Sbjct: 213 VLCFDIKINQYI 224
Score = 155 bits (393), Expect = 9e-38
Identities = 83/198 (41%), Positives = 123/198 (62%), Gaps = 2/198 (1%)
Query: 455 EDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFS 514
ED P P K++ +++ PI+ L++T PD RK + +F ITFF S WI+ F+
Sbjct: 290 EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFT 349
Query: 515 YLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIF 574
Y++VW GET+ I + +MGLT+LAAGTSIPD I SV+VARKG GDMA+S+ VGSN+F
Sbjct: 350 YILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVF 409
Query: 575 DITVGLPLPWLLYTV-IHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILG 633
D+ + L +PW + T I+ P V+S GL + L I ++F+ L++ W++++ LG
Sbjct: 410 DM-LCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLG 468
Query: 634 FIMFGLYFVFLVVSVLLE 651
+ Y +SVL E
Sbjct: 469 IVCLLSYLGLATLSVLYE 486
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/134 (24%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLP 583
+ E++G+S+++ G T +AAG+S P+L+T+ + GD+ +S+ +GS I+++
Sbjct: 98 ISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAAC 157
Query: 584 WLLYTVIHRFQPVAVSSNGLF--CAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYF 641
LL + +S LF CA + + I+ W +L +++GLY
Sbjct: 158 GLLSNTVS-----TLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALL-LLIYGLYV 211
Query: 642 VFLVVSVLLEDRIL 655
+ L + + I+
Sbjct: 212 LVLCFDIKINQYII 225
Score = 39.3 bits (90), Expect = 0.012
Identities = 21/57 (36%), Positives = 32/57 (56%)
Query: 161 LTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL 217
+T+ E L I D V G T +AAG S P+ S++ ++ + IVGS VF++L
Sbjct: 356 VTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML 412
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/262 (24%), Positives = 121/262 (46%), Gaps = 23/262 (8%)
Query: 48 AISTVSFSISAFSETDTQSTGEASVVSGPRVAQGYHQRTLLD--------LNDKILDYTP 99
A+S + + A + + T+ + + +S A G +Q ++D ++D+
Sbjct: 11 ALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRT 70
Query: 100 QPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVP 159
P +G + + +P + L A+ L+V ++Y+F+ L + +FF P
Sbjct: 71 NPDCHSDGGYLDYLEGIFCHFPPSLLPL------AVTLYVSWLLYLFLILGVTAAKFFCP 124
Query: 160 SLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAH-SNVGIGTIVGSAVFNILF 218
+L+ I+ L +S +VAG TF+A G AP++F++L+ H + + +G + G+ V
Sbjct: 125 NLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTV 184
Query: 219 VIGMCALFSREILNLTWWPLFRDVSFYIVDLIM-LIIFFLDNVIMWWESLLLLTAYFCYV 277
V G + + P FRD+ FY+V + + ++ F V + W +L L Y YV
Sbjct: 185 VAGGITILHPFMAASR--PFFRDIVFYMVAVFLTFLMLFRGRVTLAW-ALGYLGLYVFYV 241
Query: 278 VFMKFNVQVEKWVKQMINRNKV 299
V V + W+ Q R +
Sbjct: 242 V----TVILCTWIYQRQRRGSL 259
Score = 70.1 bits (170), Expect = 6e-12
Identities = 48/151 (31%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD 562
F S WI + +V +G +S ++GLT+LA G SI D + +AR+G
Sbjct: 426 FLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPR 485
Query: 563 MAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIV--LLFIMLLFVILS 620
MA S+ G IF+I VG+ L LL + V + +GL ++ L + L+F ++S
Sbjct: 486 MAFSACFGGIIFNILVGVGLGCLL-QISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVS 544
Query: 621 IALCKWRMNKILGFIMFGLYFVFLVVSVLLE 651
+ L ++++++ GF + Y FLVV++L E
Sbjct: 545 VPLQCFQLSRVYGFCLLLFYLNFLVVALLTE 575
Score = 38.1 bits (87), Expect = 0.026
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 17/131 (12%)
Query: 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIV-ARKGLGDMAVSSSVGSNIFDITV---G 579
+ T+ +S + G+T LA G PD+ ++++ + +A+ + G+ + TV G
Sbjct: 129 ISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGG 188
Query: 580 LPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGL 639
+ T++H P +S F IV + + L + + + LG++ GL
Sbjct: 189 I-------TILH---PFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYL--GL 236
Query: 640 YFVFLVVSVLL 650
Y VF VV+V+L
Sbjct: 237 Y-VFYVVTVIL 246
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/225 (30%), Positives = 102/225 (45%), Gaps = 50/225 (22%)
Query: 98 TPQPPLSKEGESENSTDHAQGDY-----------PKDIFSLEERRKGAIILHVIGMIYMF 146
TP P +S+ ST QG Y D SL ++ A++ + + M+YMF
Sbjct: 25 TPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVV-YFVAMVYMF 83
Query: 147 IALAIVCDEFFVPSLTVITEK--------------LGI----SDDVAGATFMAAGGSAPE 188
+ ++I+ D F ++ VIT K +G ++ V+ T MA G SAPE
Sbjct: 84 LGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPE 142
Query: 189 LFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMC-----ALFSREILNL------T 234
+ S+I V +G GTIVGSA FN+ VI +C A SR+I +L
Sbjct: 143 ILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTA 202
Query: 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
W +F V Y++ + F V+ WE+LL L + VVF
Sbjct: 203 SWSIFAYVWLYLI-----LAVFSPGVVQVWEALLTLVFFPVCVVF 242
Score = 53.1 bits (126), Expect = 8e-07
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 8/188 (4%)
Query: 443 IEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPIT 502
+E DEEE++ S E R F V + W L P+
Sbjct: 696 LEAITVSAGDEEEEEDGS----REERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWAC 751
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA-RKGLG 561
F SI I + + L+ A G T+G+ + + + +A GTSIPD S + A +
Sbjct: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
Query: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQ--PVAVSSNGLFCAIVLLFIMLLFVIL 619
D ++ + GSN ++ +GL + W + V Q P V + G V LF + FV +
Sbjct: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRT-GTLAFSVTLFTVFAFVGI 870
Query: 620 SIALCKWR 627
++ L + R
Sbjct: 871 AVLLYRRR 878
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
Query: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
Query: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 710 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 763
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 764 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 823
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 824 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 881
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 780 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 835
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
Query: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
Query: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 707 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 760
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 761 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 820
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 821 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 878
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 777 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 832
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
Query: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
Query: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 711 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 764
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 765 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 824
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 825 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 882
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 836
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
Query: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
Query: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 713 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 766
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 767 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 826
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 827 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 884
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 783 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 838
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 38/175 (21%)
Query: 137 LHVIGMIYMFIALAIVCDEFFVPSLTVIT---EKLGI---------------SDDVAGAT 178
++ + M+YMF+ ++I+ D F + S+ VIT +++ I ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 179 FMAAGGSAPELFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMCALF-----SREI 230
MA G SAPE+ S+I V ++G TIVGSA FN+ +I +C +R+I
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 231 LNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
+L W +F YI+ + V+ WE LL + VVF
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYII-----LSVISPGVVEVWEGLLTFFFFPICVVF 248
Score = 50.4 bits (119), Expect = 5e-06
Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 2/127 (1%)
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 561
F SI I + + + A G TIG+ + + + +A GTS+PD S + A +
Sbjct: 804 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 863
Query: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILS 620
D ++ + GSN ++ +G+ + W + + H S G V LF + F+ +
Sbjct: 864 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVG 923
Query: 621 IALCKWR 627
+ L + R
Sbjct: 924 VLLYRRR 930
Score = 35.4 bits (80), Expect = 0.17
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S + +++ IG + GS N+ IG+
Sbjct: 829 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGV 884
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITVGLPL 582
+E + LT++A G+S P+++ SVI GD+ S+ VGS F++ + + L
Sbjct: 131 NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIAL 185
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 38/175 (21%)
Query: 137 LHVIGMIYMFIALAIVCDEFFVPSLTVIT---EKLGI---------------SDDVAGAT 178
++ + M+YMF+ ++I+ D F + S+ VIT +++ I ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 179 FMAAGGSAPELFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMCALF-----SREI 230
MA G SAPE+ S+I V ++G TIVGSA FN+ +I +C +R+I
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 231 LNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
+L W +F YI+ + V+ WE LL + VVF
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYII-----LSVISPGVVEVWEGLLTFFFFPICVVF 248
Score = 50.4 bits (119), Expect = 5e-06
Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 2/127 (1%)
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 561
F SI I + + + A G TIG+ + + + +A GTS+PD S + A +
Sbjct: 768 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 827
Query: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILS 620
D ++ + GSN ++ +G+ + W + + H S G V LF + F+ +
Sbjct: 828 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVG 887
Query: 621 IALCKWR 627
+ L + R
Sbjct: 888 VLLYRRR 894
Score = 35.4 bits (80), Expect = 0.17
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S + +++ IG + GS N+ IG+
Sbjct: 793 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGV 848
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITVGLPL 582
+E + LT++A G+S P+++ SVI GD+ S+ VGS F++ + + L
Sbjct: 131 NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIAL 185
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 38/175 (21%)
Query: 137 LHVIGMIYMFIALAIVCDEFFVPSLTVIT---EKLGI---------------SDDVAGAT 178
++ + M+YMF+ ++I+ D F + S+ VIT +++ I ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 179 FMAAGGSAPELFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMCALF-----SREI 230
MA G SAPE+ S+I V ++G TIVGSA FN+ +I +C +R+I
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 231 LNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
+L W +F YI+ + V+ WE LL + VVF
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYII-----LSVISPGVVEVWEGLLTFFFFPICVVF 248
Score = 50.4 bits (119), Expect = 5e-06
Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 2/127 (1%)
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 561
F SI I + + + A G TIG+ + + + +A GTS+PD S + A +
Sbjct: 791 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 850
Query: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILS 620
D ++ + GSN ++ +G+ + W + + H S G V LF + F+ +
Sbjct: 851 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVG 910
Query: 621 IALCKWR 627
+ L + R
Sbjct: 911 VLLYRRR 917
Score = 35.4 bits (80), Expect = 0.17
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S + +++ IG + GS N+ IG+
Sbjct: 816 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGV 871
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITVGLPL 582
+E + LT++A G+S P+++ SVI GD+ S+ VGS F++ + + L
Sbjct: 131 NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIAL 185
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 58.5 bits (140), Expect = 2e-08
Identities = 50/175 (28%), Positives = 81/175 (46%), Gaps = 38/175 (21%)
Query: 137 LHVIGMIYMFIALAIVCDEFFVPSLTVIT---EKLGI---------------SDDVAGAT 178
++ + M+YMF+ ++I+ D F + S+ VIT +++ I ++ V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 179 FMAAGGSAPELFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMCALF-----SREI 230
MA G SAPE+ S+I V ++G TIVGSA FN+ +I +C +R+I
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 231 LNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
+L W +F YI+ + V+ WE LL + VVF
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYII-----LSVISPGVVEVWEGLLTFFFFPICVVF 248
Score = 50.4 bits (119), Expect = 5e-06
Identities = 32/127 (25%), Positives = 58/127 (45%), Gaps = 2/127 (1%)
Query: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LG 561
F SI I + + + A G TIG+ + + + +A GTS+PD S + A +
Sbjct: 799 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYA 858
Query: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILS 620
D ++ + GSN ++ +G+ + W + + H S G V LF + F+ +
Sbjct: 859 DASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVG 918
Query: 621 IALCKWR 627
+ L + R
Sbjct: 919 VLLYRRR 925
Score = 35.4 bits (80), Expect = 0.17
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S + +++ IG + GS N+ IG+
Sbjct: 824 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGV 879
Score = 32.0 bits (71), Expect = 1.9
Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 3/55 (5%)
Query: 531 SEEIMGLTILAAGTSIPDLITSVIVA---RKGLGDMAVSSSVGSNIFDITVGLPL 582
+E + LT++A G+S P+++ SVI GD+ S+ VGS F++ + + L
Sbjct: 131 NETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIAL 185
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 70 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 123
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 124 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 183
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 184 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 241
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 140 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 195
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 84 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 137
Query: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 138 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 197
Query: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 198 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 255
Score = 35.0 bits (79), Expect = 0.22
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 154 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 209
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 35.0 bits (79), Expect = 0.22
Identities = 32/143 (22%), Positives = 57/143 (39%), Gaps = 11/143 (7%)
Query: 306 EAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLD-----PLAEE 360
E+ P ++ ++P LP +R + LH+S + + QL+ D PLA
Sbjct: 601 ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS 660
Query: 361 LG-----SYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELP 415
L S G L + T +EK ILH++ + + + A + +
Sbjct: 661 LSDTNKDSTGSLPGSGS-THGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQES 719
Query: 416 NSTSTDVEMTPSSDASEPVQNGN 438
+ST+ E+T + P + N
Sbjct: 720 SSTAPGSEVTIKQEPVSPKKKEN 742
>gi|149999615 variable charge, X-linked 3B [Homo sapiens]
Length = 216
Score = 35.0 bits (79), Expect = 0.22
Identities = 37/170 (21%), Positives = 74/170 (43%), Gaps = 29/170 (17%)
Query: 298 KVVKVTAPEAQAKPSAARDKDEPT-------LPAKPRLQRGGSSASLHNSLMRNSIFQLM 350
K+ VTAPEA++ P+A D+P+ LP + + G + H+ L + S +
Sbjct: 58 KMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEG----TQHDPLSQESELE-- 111
Query: 351 IHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVE 410
+PL++E + + +++E + E S ++ + + E + VE
Sbjct: 112 ----EPLSQE------SEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVE 161
Query: 411 KIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLS 460
+ L + + ++ S+ EP LS + E + + E ++PLS
Sbjct: 162 E-PLSQESQVEEPLSQESEMEEP-----LSQESQVEEPLSQESEMEEPLS 205
>gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform b
[Homo sapiens]
Length = 807
Score = 33.9 bits (76), Expect = 0.49
Identities = 20/102 (19%), Positives = 45/102 (44%)
Query: 367 LKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTP 426
LK + ++ + ++K + ++K VD++ + ++K+ +P S D P
Sbjct: 59 LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP 118
Query: 427 SSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETR 468
+ + GN+ + +++ +EEE P A P + R
Sbjct: 119 KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR 160
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 33.9 bits (76), Expect = 0.49
Identities = 20/102 (19%), Positives = 45/102 (44%)
Query: 367 LKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEMTP 426
LK + ++ + ++K + ++K VD++ + ++K+ +P S D P
Sbjct: 59 LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP 118
Query: 427 SSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETR 468
+ + GN+ + +++ +EEE P A P + R
Sbjct: 119 KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR 160
>gi|134288865 solute carrier family 4, sodium bicarbonate
cotransporter, member 7 [Homo sapiens]
Length = 1214
Score = 33.9 bits (76), Expect = 0.49
Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 10/138 (7%)
Query: 193 LIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIML 252
L GVF+ +G+ ++ G +F+ + + GM A +++ L + PL++ F ++ L L
Sbjct: 1037 LYGVFLY---MGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCL 1093
Query: 253 IIFFLDNV---IMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVVKVTAPEAQA 309
++ ++ V + + ++L + ++ + F + W+ ++ +K K + +
Sbjct: 1094 VLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKE 1153
Query: 310 KPSAAR----DKDEPTLP 323
K A R D D LP
Sbjct: 1154 KEEAERMLQDDDDTVHLP 1171
>gi|157266307 aquaporin 9 [Homo sapiens]
Length = 295
Score = 32.7 bits (73), Expect = 1.1
Identities = 33/135 (24%), Positives = 57/135 (42%), Gaps = 35/135 (25%)
Query: 110 ENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMF----------------IALAIVC 153
EN+T H YP SL ++ +I +I +F IA+ ++
Sbjct: 141 ENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLL- 199
Query: 154 DEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIG----VFIAHSNVG----I 205
+ VI LG++ +G A +P LFT+L G VF A +N +
Sbjct: 200 -------IIVIASSLGLN---SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVV 249
Query: 206 GTIVGSAVFNILFVI 220
G +VG+ + +++V+
Sbjct: 250 GPLVGAVIGGLIYVL 264
>gi|66932943 variable charge, X chromosome [Homo sapiens]
Length = 206
Score = 32.7 bits (73), Expect = 1.1
Identities = 32/147 (21%), Positives = 63/147 (42%), Gaps = 20/147 (13%)
Query: 298 KVVKVTAPEAQAKPSAARDKDEPT-------LPAKPRLQRGGSSASLHNSLMRNSIFQLM 350
K+ VTAPEA++ P+A D+P+ LP + + G + H+ L + + +
Sbjct: 58 KMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEG----TQHDPLSQEAELEEP 113
Query: 351 IHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVE 410
+ + E L +++ + +++E E S ++ + E E + VE
Sbjct: 114 LSQESEVEEPLSQESQVE--EPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVE 171
Query: 411 -------KIELPNSTSTDVEMTPSSDA 430
++E P S + VE PS ++
Sbjct: 172 EPLSQESEMEEPLSQESQVEEPPSQES 198
>gi|48762947 variable charge, X-linked 3A [Homo sapiens]
Length = 186
Score = 32.3 bits (72), Expect = 1.4
Identities = 31/137 (22%), Positives = 60/137 (43%), Gaps = 16/137 (11%)
Query: 298 KVVKVTAPEAQAKPSAARDKDEPT-------LPAKPRLQRGGSSASLHNSLMRNSIFQLM 350
K+ VTAPEA++ P+A D+P+ LP + + G + H+ L + S +
Sbjct: 58 KMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEG----TQHDPLSQESELEEP 113
Query: 351 IHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVE 410
+ + E L +++ + +++E E S ++ + E E + VE
Sbjct: 114 LSQESEVEEPLSQESQVE--EPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVE 171
Query: 411 KIELPNSTSTDVEMTPS 427
+ P S +++E PS
Sbjct: 172 E---PLSQESEMEELPS 185
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 32.3 bits (72), Expect = 1.4
Identities = 33/154 (21%), Positives = 59/154 (38%), Gaps = 18/154 (11%)
Query: 305 PEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSY 364
P A +K A D +P+ + + GS ++ S P S+
Sbjct: 280 PRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTS---------------PRTSSSSSF 324
Query: 365 GKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTSTDVEM 424
K + + KA + AKK V+E+ ++ A+ E + S S+
Sbjct: 325 SDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSD 384
Query: 425 TPSSDASEPVQN---GNLSHNIEGAEAQTADEEE 455
+ S EP QN G L +E +++ +DE++
Sbjct: 385 SSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDD 418
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 32.3 bits (72), Expect = 1.4
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 5/46 (10%)
Query: 605 CAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLL 650
CA+ L+F L +LS KWR N GF FG + + + VS ++
Sbjct: 1023 CAVSLIF---LTYVLSFIFRKWRKNN--GFWSFGFFIILICVSTIM 1063
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 31.6 bits (70), Expect = 2.4
Identities = 17/78 (21%), Positives = 38/78 (48%), Gaps = 6/78 (7%)
Query: 391 KKKCHVDENERQNGAANHVEKIELPNSTST------DVEMTPSSDASEPVQNGNLSHNIE 444
++KC +D N N + + + +P+S +T ++P ++ +++HN +
Sbjct: 1117 EEKCRLDVNTELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQK 1176
Query: 445 GAEAQTADEEEDQPLSLA 462
E A+EEE +++A
Sbjct: 1177 CKEKMEAEEEEALAIAMA 1194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,223,156
Number of Sequences: 37866
Number of extensions: 1006874
Number of successful extensions: 3326
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 3206
Number of HSP's gapped (non-prelim): 107
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.