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Search of human proteins with 94536852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
sapiens]
(906 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap... 1831 0.0
gi|21071070 transmembrane channel-like 1 [Homo sapiens] 893 0.0
gi|122937502 transmembrane channel-like 3 [Homo sapiens] 639 0.0
gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens] 216 6e-56
gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens] 213 8e-55
gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens] 172 1e-42
gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens] 172 1e-42
gi|23943900 transmembrane channel-like 8 [Homo sapiens] 154 5e-37
gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens] 135 1e-31
gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens] 134 4e-31
gi|187608784 transmembrane channel-like 6 [Homo sapiens] 125 2e-28
gi|187608791 transmembrane channel-like 6 [Homo sapiens] 125 2e-28
gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens] 118 3e-26
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 54 5e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 49 2e-05
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 49 2e-05
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 48 5e-05
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 47 8e-05
gi|50409691 SRp25 nuclear protein isoform 4 [Homo sapiens] 47 1e-04
gi|50409707 SRp25 nuclear protein isoform 2 [Homo sapiens] 47 1e-04
gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo ... 46 1e-04
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 46 2e-04
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 46 2e-04
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens] 46 2e-04
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 45 3e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 45 3e-04
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 45 3e-04
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 45 3e-04
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 45 4e-04
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre... 44 5e-04
>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
sapiens]
Length = 906
Score = 1832 bits (4744), Expect = 0.0
Identities = 906/906 (100%), Positives = 906/906 (100%)
Query: 1 MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERA 60
MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERA
Sbjct: 1 MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERA 60
Query: 61 GGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI 120
GGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI
Sbjct: 61 GGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI 120
Query: 121 PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK 180
PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK
Sbjct: 121 PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK 180
Query: 181 LTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKD 240
LTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKD
Sbjct: 181 LTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKD 240
Query: 241 IESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEK 300
IESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEK
Sbjct: 241 IESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEK 300
Query: 301 AMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSM 360
AMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSM
Sbjct: 301 AMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSM 360
Query: 361 ASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKE 420
ASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKE
Sbjct: 361 ASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKE 420
Query: 421 ENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLG 480
ENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLG
Sbjct: 421 ENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLG 480
Query: 481 MFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKN 540
MFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKN
Sbjct: 481 MFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKN 540
Query: 541 ITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILL 600
ITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILL
Sbjct: 541 ITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILL 600
Query: 601 GDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGIN 660
GDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGIN
Sbjct: 601 GDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGIN 660
Query: 661 VLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPS 720
VLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPS
Sbjct: 661 VLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPS 720
Query: 721 FDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSK 780
FDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSK
Sbjct: 721 FDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSK 780
Query: 781 SLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPS 840
SLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPS
Sbjct: 781 SLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPS 840
Query: 841 ASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKS 900
ASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKS
Sbjct: 841 ASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKS 900
Query: 901 AQRPPH 906
AQRPPH
Sbjct: 901 AQRPPH 906
>gi|21071070 transmembrane channel-like 1 [Homo sapiens]
Length = 760
Score = 893 bits (2307), Expect = 0.0
Identities = 439/757 (57%), Positives = 562/757 (74%), Gaps = 15/757 (1%)
Query: 68 SPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI---PRRE 124
SP++ Q +E E E E + +R+ ++RT E + P E
Sbjct: 2 SPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDE 61
Query: 125 EKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTEL 184
E K ++K R L A E + EEEL ++ +++EK+++IAT++ KPW M KK+ L
Sbjct: 62 ETRKAREKERRRRLKRGAEE-EEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVL 120
Query: 185 REAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESH 244
+EA++FV + EGALGKGKGK+ +A+KM+MAKKW KF RDF+NFK C+PWE KIK IES
Sbjct: 121 KEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQ 180
Query: 245 FGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDF 304
FGSSVASYF+FLRWMYGVN+VLF L F L+++PE L G+PYGS+PRKTVPRAEE A +F
Sbjct: 181 FGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANF 240
Query: 305 SVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNT 364
VL+DF G +YS LFYGYY+N+RTIGW+ +RLP++YF+VG+ GYS ++V+++M N
Sbjct: 241 GVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNI 300
Query: 365 QGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIH 424
G G G+ + F FS+K+FTSWDYLIGN ETADNK+ SIT +FKE+I +E+ + EEN+H
Sbjct: 301 -GDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVH 359
Query: 425 LTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQ--NVSWYERNEVEIVMSLLGMF 482
L RFLR LANF + L GSGYLI++ VKRSQ+F++ + W+E+NE+ +VMSLLGMF
Sbjct: 360 LIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMF 419
Query: 483 CPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIK-NI 541
CP LF+ A LE+YHP LKW LGRIFAL LGNLY F+LALMD+++ K+ E+ +K NI
Sbjct: 420 CPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANI 479
Query: 542 THW--TLFNYYNSSGWNESVPRPP--LHPADVPRGSCWETAVGIEFMRLTVSDMLVTYIT 597
T W + YN+S ++E+ PP +HPADVPRG CWET VG EF+RLTVSD+L TY+T
Sbjct: 480 TLWEANMIKAYNAS-FSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVT 538
Query: 598 ILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLV 657
IL+GDFLRACFVRF NYCWCWDLE G+PSY EFDISGNVL LIFNQGMIWMGSF+AP L
Sbjct: 539 ILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLP 598
Query: 658 GINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSL 717
GIN+LRL TSMYFQCWAVM NVP RVFKASRSNNFY+G+LLL+LFLS +PV Y I+SL
Sbjct: 599 GINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSL 658
Query: 718 PPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNS 777
PPSFDCGPFSGKNRM++V+ ET+E+DFP+++ KI L+NPGL+I IL+M LAIYYLN+
Sbjct: 659 PPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNA 718
Query: 778 VSKSLSRANAQLRK--KIQVLREVEKSHKSVKGKATA 812
+K AN L+K K+Q L ++ K +A A
Sbjct: 719 TAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAA 755
>gi|122937502 transmembrane channel-like 3 [Homo sapiens]
Length = 1100
Score = 639 bits (1647), Expect = 0.0
Identities = 334/789 (42%), Positives = 488/789 (61%), Gaps = 48/789 (6%)
Query: 136 SSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYE 195
S+L S S E+ + QI + ++ +K L+A +R +PW M +KL LR+A+ V K+E
Sbjct: 30 SNLDDSFSADETGDSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFE 89
Query: 196 GALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIF 255
G L + +G Y+ A+ W KF R NF IPWEM+IK IESHFGS VASYFIF
Sbjct: 90 GRLTRTRG-----YQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIF 144
Query: 256 LRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIK 315
LRW++G+N+VL + ++IPE++ G P+GS RKT+P+ + A D +W GY++
Sbjct: 145 LRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQ 204
Query: 316 YSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDN 375
YS LFYGYY +R IG YRLP+AYF+VG++VF YS II+++ MA N++ S ++N
Sbjct: 205 YSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNEN 264
Query: 376 FTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANF 435
+TF +++F +WDYLIGN E A++K A+I S +E+I++EQE K +N+ +T LR++AN
Sbjct: 265 YTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANI 324
Query: 436 LIICCLCGSGYLIYFVVKRSQQFSK-MQNVSWYERNEVEIVMSLLGMFCPPLFETIAALE 494
L++ L GS YLIYFVV RSQ+ + + ++ +E+NEV +V+SL+ M P F+ IAALE
Sbjct: 325 LVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMIAPSAFDLIAALE 384
Query: 495 NYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNIT-HW----TLF-- 547
YHPRT L++QL R+ L+LGNLY+ ++AL+D V+ E KN T HW T F
Sbjct: 385 MYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFAT 444
Query: 548 -NYYNSSGWNESVP----------------------------RPPLHPADVPRGSCWETA 578
W+ S P + LH P+ CWET
Sbjct: 445 RTAPEEEKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLH-TQSPQDQCWETY 503
Query: 579 VGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLG 638
VG E ++L++ DML T +ILL DF R FVR+++ WCWDLE+ FP Y EF I+ NVL
Sbjct: 504 VGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLH 563
Query: 639 LIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGL 698
L++NQGMIWMG+F++P L NVL+L+ MY + WAV++ NVPH++VF+ASRSNNFY+ +
Sbjct: 564 LVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAM 623
Query: 699 LLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANP 758
LL +LFL +LP + I+ PS +CGPFSG+ ++YD++ ETIE DFP + G + +++P
Sbjct: 624 LLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSP 683
Query: 759 GLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDT 818
+I+PA+LL+F+ IYYL S+++SL +N QL+ +IQ R +K + +A + E+
Sbjct: 684 VVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQMVEARIQTQEE- 742
Query: 819 PKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPG 878
S+ K LT + ++ S + + G+S S T+ S +P S PG
Sbjct: 743 --STKKLPNDSDLTSQLSSAHSGTPQNNGNVAHFDSGSSKSGRIETVAQS--MPQSPRPG 798
Query: 879 IGPDSGHAP 887
S P
Sbjct: 799 DRAPSSPLP 807
>gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens]
Length = 723
Score = 216 bits (551), Expect = 6e-56
Identities = 184/774 (23%), Positives = 335/774 (43%), Gaps = 110/774 (14%)
Query: 58 ERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKRE 117
E +G + PG P R+ H E L + +C + + +R
Sbjct: 3 ESSGSALQPGRPSRQPAV---HPENLS------LDSSCFSSPPVNFLQELPSYRSIARRR 53
Query: 118 KEIPRREEKSKRQKKPRSSSLASSASG-GESLSEEELAQILEQVEEKKKLIATMRSKPWP 176
+ R+++S KP S + E+LS L + EK++L
Sbjct: 54 TTVHSRDKQSGTLLKPTDSYSSQLEDRIAENLSSHSLRNYALNISEKRRL---------- 103
Query: 177 MAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEM 236
R+ QE KY + +K +K W +F T W
Sbjct: 104 --------RDIQETQMKYLSEWDQ--------WKRYSSKSWKRFLEKAREMTTHLELWRE 147
Query: 237 KIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRA 296
I+ IE FG+ + SYF FLR++ +NLV+F +IF LV++P +L + +P
Sbjct: 148 DIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPVLLTKYKITNSSFVLIPFK 207
Query: 297 EEEKAMD------------FSVLWDF---EGYIKYSALFYGYYNNQRTIGWLR-----YR 336
+ +K +S + D G+++ ++LFYG+Y TI ++ Y
Sbjct: 208 DMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHY----TIDGVKFQNFTYD 263
Query: 337 LPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETA 396
LP+AY + ++ SL+ +++ + + E ++ K+F WD+ I N A
Sbjct: 264 LPLAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMA 323
Query: 397 DNKYASITTSFKESIVDEQ------ESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYF 450
D K++S+ + + +E+ E EE I + LR+ N +++ L Y IY
Sbjct: 324 DLKHSSLRYELRADLEEERMRQKIAERTSEETIRIYS-LRLFLNCIVLAVLGACFYAIYV 382
Query: 451 VVKRSQQFSKMQNVSWYERNEV------EIVMSLLGMFCPPLFETIAALENYHPRTGLKW 504
SQ+ K + + IV++L P +F I E+Y P ++
Sbjct: 383 ATVFSQEHMKKEIDKMVFGENLFILYLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRL 442
Query: 505 QLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPL 564
+ R + L + + L + +++T + G+N+ L
Sbjct: 443 TILRCVFMRLATICVLVFTLGSKI--TSCDDDTC------------DLCGYNQK-----L 483
Query: 565 HPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYC---WCWDLE 621
+P CWET VG E +L + D ++ L DF R V + + C CW +
Sbjct: 484 YP-------CWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWGQQ 536
Query: 622 AGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVP 681
EF I NVLG+++ Q + W+G+F++P L I L+ + Y + W+++ + P
Sbjct: 537 -------EFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRP 589
Query: 682 HERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIE 741
R F+AS SN F++ +LL+ L L+++P+ +I +P S CGPF+ N ++V+ +T+
Sbjct: 590 SPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTV- 648
Query: 742 NDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQV 795
+ FP+ L + + +P +++ L ++Y +++ + R QLR+++ +
Sbjct: 649 STFPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSL 702
>gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens]
Length = 613
Score = 213 bits (541), Expect = 8e-55
Identities = 156/622 (25%), Positives = 288/622 (46%), Gaps = 74/622 (11%)
Query: 209 YKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFG 268
+K +K W +F T W I+ IE FG+ + SYF FLR++ +NLV+F
Sbjct: 10 WKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFL 69
Query: 269 LIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMD------------FSVLWDF---EGY 313
+IF LV++P +L + +P + +K +S + D G+
Sbjct: 70 IIFMLVLLPVLLTKYKITNSSFVLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGF 129
Query: 314 IKYSALFYGYYNNQRTIGWLR-----YRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGST 368
++ ++LFYG+Y TI ++ Y LP+AY + ++ SL+ +++ + +
Sbjct: 130 LEETSLFYGHY----TIDGVKFQNFTYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINL 185
Query: 369 GEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQ------ESNKEEN 422
E ++ K+F WD+ I N AD K++S+ + + +E+ E EE
Sbjct: 186 IRSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERMRQKIAERTSEET 245
Query: 423 IHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEV------EIVM 476
I + LR+ N +++ L Y IY SQ+ K + + IV+
Sbjct: 246 IRIYS-LRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLFILYLPSIVI 304
Query: 477 SLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEE 536
+L P +F I E+Y P ++ + R + L + + L + +++
Sbjct: 305 TLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKI--TSCDDD 362
Query: 537 TIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYI 596
T + G+N+ L+P CWET VG E +L + D ++
Sbjct: 363 TC------------DLCGYNQK-----LYP-------CWETQVGQEMYKLMIFDFIIILA 398
Query: 597 TILLGDFLRACFVRFMNYC---WCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYA 653
L DF R V + + C CW + EF I NVLG+++ Q + W+G+F++
Sbjct: 399 VTLFVDFPRKLLVTYCSSCKLIQCWGQQ-------EFAIPDNVLGIVYGQTICWIGAFFS 451
Query: 654 PGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYT 713
P L I L+ + Y + W+++ + P R F+AS SN F++ +LL+ L L+++P+ +
Sbjct: 452 PLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPLTIS 511
Query: 714 IMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIY 773
I +P S CGPF+ N ++V+ +T+ + FP+ L + + +P +++ L ++
Sbjct: 512 ISRIPSSKACGPFTNFNTTWEVIPKTV-STFPSSLQSFIHGVTSEAFAVPFFMIICLIMF 570
Query: 774 YLNSVSKSLSRANAQLRKKIQV 795
Y +++ + R QLR+++ +
Sbjct: 571 YFIALAGAHKRVVIQLREQLSL 592
>gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens]
Length = 706
Score = 172 bits (436), Expect = 1e-42
Identities = 165/647 (25%), Positives = 287/647 (44%), Gaps = 71/647 (10%)
Query: 171 RSKPWPM-AKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKT 229
R PWPM A++ R A Y G G + + L+ + K K + +
Sbjct: 85 RELPWPMQARRAHRQRNASRDQVVY------GSGTKTDRWARLLRRSKEKTKEGLRSLQ- 137
Query: 230 QCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSI- 288
PW +K I FG+ SYF LR++ +N++ L+ + ++P L G P G
Sbjct: 138 ---PWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLPTWLGGAPPGPPG 194
Query: 289 PRKTVP----RAEEEKAMDFSV----LWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMA 340
P + P + + F+ L EGY+++S LFYG+Y R RL +
Sbjct: 195 PDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPP-------RPRLAVT 247
Query: 341 YFMVGVSVFGYSLIIVI-RSMASNTQGSTGEGESDNFTFSFKMFTSWDY-LIGNSETADN 398
Y +V L++++ RS++ Q E E+ ++S ++F++WD+ L G+
Sbjct: 248 YLCWAFAVGLICLLLILHRSVSGLKQTLLAESEALT-SYSHRVFSAWDFGLCGDVHVRLR 306
Query: 399 KYA---SITTSFKESIVDEQESNKEENIHLTRFL-RVLANFLIICCLCGSGYLIYFVVKR 454
+ + +E++V Q + + +L RVL N L++ L + Y +Y+
Sbjct: 307 QRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWATGC 366
Query: 455 SQQFSKMQNVSWYERNEV------EIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGR 508
+ + +M V ++ I ++ + PP+F+ IA LE Y + + L R
Sbjct: 367 TVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFILLR 426
Query: 509 IFALFLGNLYTFLLALMDDVHLKLANE-ETIKNITHWTLFNYYNSSGWNESVPRPPLHPA 567
L L +L L +L + + +E E K +NY + +P
Sbjct: 427 TVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCG----YNY-------KQLP------- 468
Query: 568 DVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSY 627
CWET +G E +L + D+L LL F R C
Sbjct: 469 ------CWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGL-----CPGALGRLAGT 517
Query: 628 AEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFK 687
EF + VLGLI+ Q ++W+GSF+ P L +N ++ L Y + + S+ P R F+
Sbjct: 518 QEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFR 577
Query: 688 ASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTF 747
AS +N F+ +LLL L +S +P+ Y+I +PPS CGPF G++ ++ + E+I + P
Sbjct: 578 ASAANFFFPLVLLLGLAISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESI-SSLPET 636
Query: 748 LGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQ 794
FL +P +L+ + + Y +++ S R ++L+++ Q
Sbjct: 637 TQNFLFFLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQ 683
>gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens]
Length = 712
Score = 172 bits (436), Expect = 1e-42
Identities = 165/647 (25%), Positives = 287/647 (44%), Gaps = 71/647 (10%)
Query: 171 RSKPWPM-AKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKT 229
R PWPM A++ R A Y G G + + L+ + K K + +
Sbjct: 91 RELPWPMQARRAHRQRNASRDQVVY------GSGTKTDRWARLLRRSKEKTKEGLRSLQ- 143
Query: 230 QCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSI- 288
PW +K I FG+ SYF LR++ +N++ L+ + ++P L G P G
Sbjct: 144 ---PWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLPTWLGGAPPGPPG 200
Query: 289 PRKTVP----RAEEEKAMDFSV----LWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMA 340
P + P + + F+ L EGY+++S LFYG+Y R RL +
Sbjct: 201 PDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPP-------RPRLAVT 253
Query: 341 YFMVGVSVFGYSLIIVI-RSMASNTQGSTGEGESDNFTFSFKMFTSWDY-LIGNSETADN 398
Y +V L++++ RS++ Q E E+ ++S ++F++WD+ L G+
Sbjct: 254 YLCWAFAVGLICLLLILHRSVSGLKQTLLAESEALT-SYSHRVFSAWDFGLCGDVHVRLR 312
Query: 399 KYA---SITTSFKESIVDEQESNKEENIHLTRFL-RVLANFLIICCLCGSGYLIYFVVKR 454
+ + +E++V Q + + +L RVL N L++ L + Y +Y+
Sbjct: 313 QRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWATGC 372
Query: 455 SQQFSKMQNVSWYERNEV------EIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGR 508
+ + +M V ++ I ++ + PP+F+ IA LE Y + + L R
Sbjct: 373 TVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFILLR 432
Query: 509 IFALFLGNLYTFLLALMDDVHLKLANE-ETIKNITHWTLFNYYNSSGWNESVPRPPLHPA 567
L L +L L +L + + +E E K +NY + +P
Sbjct: 433 TVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCG----YNY-------KQLP------- 474
Query: 568 DVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSY 627
CWET +G E +L + D+L LL F R C
Sbjct: 475 ------CWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCGL-----CPGALGRLAGT 523
Query: 628 AEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFK 687
EF + VLGLI+ Q ++W+GSF+ P L +N ++ L Y + + S+ P R F+
Sbjct: 524 QEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFR 583
Query: 688 ASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTF 747
AS +N F+ +LLL L +S +P+ Y+I +PPS CGPF G++ ++ + E+I + P
Sbjct: 584 ASAANFFFPLVLLLGLAISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESI-SSLPET 642
Query: 748 LGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQ 794
FL +P +L+ + + Y +++ S R ++L+++ Q
Sbjct: 643 TQNFLFFLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQ 689
>gi|23943900 transmembrane channel-like 8 [Homo sapiens]
Length = 726
Score = 154 bits (388), Expect = 5e-37
Identities = 147/587 (25%), Positives = 256/587 (43%), Gaps = 53/587 (9%)
Query: 234 WEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTV 293
WE + +I FG+ + SYF FLR++ +NL+ L V++P V + P
Sbjct: 91 WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPTLNLT 150
Query: 294 PRAEEEKAMDFSVLWDFEGYIKY---------SALFYGYYNNQRTIGWLRYRLPMAYFMV 344
+ + VL F + + + LFYG Y + Y + +AY +
Sbjct: 151 LQCPGSRQSPPGVL-RFHNQLWHVLTGRAFTNTYLFYGAYRVGPESSSV-YSIRLAYLLS 208
Query: 345 GVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASIT 404
++ +R M T G+ S K+F+SWD+ I E A K I+
Sbjct: 209 PLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEIS 268
Query: 405 TSFKESIVD-------EQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQ 457
FK + + +Q++ + L +LRV N L + G+ I++ K SQ
Sbjct: 269 NEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRV--NVLNGLLVVGAISAIFWATKYSQD 326
Query: 458 FSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNL 517
+K +++ + V++L+ P LF + LENY P T + L L L +L
Sbjct: 327 -NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTLIWCVVLKLASL 385
Query: 518 YTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWET 577
F ++L + L + +++ + + +Y CWE
Sbjct: 386 GMFSVSLGQTI-LCIGRDKSSCESYGYNVCDY-----------------------QCWEN 421
Query: 578 AVGIEFMRLTVSDMLVTYITILLGDFLRACFV-RFMNYCWCWDLEAGFPSYAEFDISGNV 636
+VG E +L++ + L+T L R V RF W W LE EF + NV
Sbjct: 422 SVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAW-LER-----EEFLVPKNV 475
Query: 637 LGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYM 696
L ++ Q + WMG FY P L +N + L + Y + + ++ ++ R F+AS S F+
Sbjct: 476 LDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQ 535
Query: 697 GLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLA 756
+LLL L L+ +P+ Y + S+ S+DCG F+ + + V+ E + P + +L
Sbjct: 536 LVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLG 595
Query: 757 NPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSH 803
+ P ++++ L + S +++ +RA +LRK++ V + EK H
Sbjct: 596 SHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQL-VWQVQEKWH 641
>gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens]
Length = 760
Score = 135 bits (341), Expect = 1e-31
Identities = 146/640 (22%), Positives = 263/640 (41%), Gaps = 112/640 (17%)
Query: 127 SKRQKKPRSSSLASSASGGESLSEE---------ELAQILEQVEEKKKLIATMRSKPWPM 177
SKR + + L S S ES+S+ + + + +KLIA++ P
Sbjct: 59 SKRNDQKGNQVLRFSTSLNESMSQTLHSLECMGIDTPGSSHETVQGQKLIASLI--PMTS 116
Query: 178 AKKLTELREAQEFVEKYEGA---LGKGKGKQLYAYKML---------MAKKWVKFKRDFD 225
++ +R +E+ + K K KQ + L +++ + + K
Sbjct: 117 RDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLS 176
Query: 226 NFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPY 285
W+ +K I FG+SV SYF FLRW+ N+ F L F +IIP+ +
Sbjct: 177 EILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVA--- 233
Query: 286 GSIPRKTVPRAEEEKAMDFSVLWDFEG--YIKYSALFYGYYNN---QRTIGWLRYRLPMA 340
++ + F+ L F G Y + + ++YG+Y N Q Y + +A
Sbjct: 234 ------------KKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLA 281
Query: 341 YFMVGVSVFGYSLIIVIRSMASNTQGSTGEGE--SDNFTFSFKMFTSWDYLIGNSETADN 398
Y + ++ SMA + + S T K+ WD+ + + +
Sbjct: 282 YIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGIT---KLIFCWDFTVTHEKAVKL 338
Query: 399 KYASITTSFKESIVDEQESNKEENIH--LTRFLRVLANFL------IICCLCGSGYLIYF 450
K +++T +E++ + ++ N + + LTRF + ++ I CC +Y+
Sbjct: 339 KQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAA-----VYY 393
Query: 451 VVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYH-PRTGLKWQLGRI 509
+ + + +F K + + V+S + + P ++ +E Y PR +
Sbjct: 394 LAEYNLEFLKTHSNPGAVLL-LPFVVSCINLAVPCIYSMFRLVERYEMPRH-------EV 445
Query: 510 FALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADV 569
+ L + N++ I+ + YY W L+ +
Sbjct: 446 YVLLIRNIFL--------------------KISIIGILCYY----W--------LNTVAL 473
Query: 570 PRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAE 629
CWET +G + RL + D + + + LG+FLR + M L+ E
Sbjct: 474 SGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRR--IIGMQLITSLGLQ-------E 524
Query: 630 FDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKAS 689
FDI+ NVL LI+ Q ++W+G F+ P L I ++ L Y + ++M + P + ++AS
Sbjct: 525 FDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRAS 584
Query: 690 RSNNFYMGLLLLVLFLSLL-PVAYTIMSLPPSFDCGPFSG 728
+ F++ LL F +L +A TI L PS DCGPF G
Sbjct: 585 QMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRG 624
>gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens]
Length = 1006
Score = 134 bits (337), Expect = 4e-31
Identities = 137/588 (23%), Positives = 245/588 (41%), Gaps = 109/588 (18%)
Query: 167 IATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKML---------MAKKW 217
I +R++P M +K R ++ V+K K KQ + L +++ +
Sbjct: 366 IKAIRNQPRTMEEK----RNLRKIVDKE-------KSKQTHRILQLNCCIQCLNSISRAY 414
Query: 218 VKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIP 277
+ K W+ +K I FG+SV SYF FLRW+ N+ F L F +IIP
Sbjct: 415 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 474
Query: 278 EVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEG--YIKYSALFYGYYNN---QRTIGW 332
+ + ++ + F+ L F G Y + + ++YG+Y N Q
Sbjct: 475 QFTVA---------------KKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSG 519
Query: 333 LRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGE--SDNFTFSFKMFTSWDYLI 390
Y + +AY + ++ SMA + + S T K+ WD+ +
Sbjct: 520 ASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGIT---KLIFCWDFTV 576
Query: 391 GNSETADNKYASITTSFKESIVDEQESNKEENIH--LTRFLRVLANFL------IICCLC 442
+ + K +++T +E++ + ++ N + + LTRF + ++ I CC
Sbjct: 577 THEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAA 636
Query: 443 GSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYH-PRTG 501
+Y++ + + +F K + + V+S + + P ++ +E Y PR
Sbjct: 637 -----VYYLAEYNLEFLKTHSNPGAVLL-LPFVVSCINLAVPCIYSMFRLVERYEMPRH- 689
Query: 502 LKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPR 561
++ L + N++ I+ + YY W
Sbjct: 690 ------EVYVLLIRNIFL--------------------KISIIGILCYY----W------ 713
Query: 562 PPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLE 621
L+ + CWET +G + RL + D + + + LG+FLR + M L+
Sbjct: 714 --LNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRR--IIGMQLITSLGLQ 769
Query: 622 AGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVP 681
EFDI+ NVL LI+ Q ++W+G F+ P L I ++ L Y + ++M + P
Sbjct: 770 -------EFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQP 822
Query: 682 HERVFKASRSNNFYMGLLLLVLFLSLL-PVAYTIMSLPPSFDCGPFSG 728
+ ++AS+ F++ LL F +L +A TI L PS DCGPF G
Sbjct: 823 PSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRG 870
>gi|187608784 transmembrane channel-like 6 [Homo sapiens]
Length = 805
Score = 125 bits (314), Expect = 2e-28
Identities = 159/696 (22%), Positives = 273/696 (39%), Gaps = 115/696 (16%)
Query: 129 RQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIAT-------------MRSKPW 175
R +P + SA L + EL + EEK+ L+ +R P
Sbjct: 111 RSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPL 170
Query: 176 PMAKKLTELREAQEFVEKYEGALGKGK-----GKQLYAYKMLMAKKWVKFKRDFDNFKTQ 230
+A+K + +++ K+ G G G G+ YA + + +
Sbjct: 171 SLAEKRSLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQAL--- 227
Query: 231 CIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPR 290
+PW +K I FGSSV SYF+FL+ + N +L L+ ++ P+V P P
Sbjct: 228 -MPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFP-PALPGPA 285
Query: 291 KTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRT----------------IGWLR 334
E L G ++ ++YG+Y+N +G L
Sbjct: 286 PVCTGLE---------LLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLP 336
Query: 335 YRLPMAYFM-VGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNS 393
Y +P+AY VGVS F + I ++ SMA + S G + + +F SWDY +
Sbjct: 337 YNMPLAYLSTVGVSFF-ITCITLVYSMAHSFGESYRVGSTSGI-HAITVFCSWDYKVTQK 394
Query: 394 ETADNKYASITTSFKESIVDEQESNKEENI-HLTRFLRVLANFLIICCLCGSGYLIYFVV 452
+ + +I T KE + + Q + ++ R VL ++C G + V
Sbjct: 395 RASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLGLVWLLCLGTALGCAVAVHV 454
Query: 453 KRSQQFSKMQNVSWYERNE------VEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQL 506
FS+ S + + +V+ LL + P L +AALE +
Sbjct: 455 -----FSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAALEPHD--------- 500
Query: 507 GRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHP 566
+ +A+ ++ LKLA T+ HW
Sbjct: 501 --------SPVLEVYVAICRNLILKLAILGTL--CYHWLG------------------RR 532
Query: 567 ADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPS 626
V +G CWE VG E R V D ++ + L G+ + + +
Sbjct: 533 VGVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIIS---------EKKLKRRR 583
Query: 627 YAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVF 686
EFDI+ NVL LI+ Q + W+G ++P L + +++LL Y + +++++ R +
Sbjct: 584 KPEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPW 643
Query: 687 KASRSNNFYMGLLLLVLFL-SLLPVAYTIMSLPPSFDCGPFSGKNRMYD---VLQETIEN 742
AS + ++ LL FL + + + Y + + PS CGPF + MY+ V +E
Sbjct: 644 LASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEA 703
Query: 743 DFP--TFLGKIFAFLANPGLIIPAILLMFLAIYYLN 776
P ++L + +L + + + LA+ YLN
Sbjct: 704 AGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLN 739
>gi|187608791 transmembrane channel-like 6 [Homo sapiens]
Length = 805
Score = 125 bits (314), Expect = 2e-28
Identities = 159/696 (22%), Positives = 273/696 (39%), Gaps = 115/696 (16%)
Query: 129 RQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIAT-------------MRSKPW 175
R +P + SA L + EL + EEK+ L+ +R P
Sbjct: 111 RSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPL 170
Query: 176 PMAKKLTELREAQEFVEKYEGALGKGK-----GKQLYAYKMLMAKKWVKFKRDFDNFKTQ 230
+A+K + +++ K+ G G G G+ YA + + +
Sbjct: 171 SLAEKRSLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQAL--- 227
Query: 231 CIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPR 290
+PW +K I FGSSV SYF+FL+ + N +L L+ ++ P+V P P
Sbjct: 228 -MPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFP-PALPGPA 285
Query: 291 KTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRT----------------IGWLR 334
E L G ++ ++YG+Y+N +G L
Sbjct: 286 PVCTGLE---------LLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLP 336
Query: 335 YRLPMAYFM-VGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNS 393
Y +P+AY VGVS F + I ++ SMA + S G + + +F SWDY +
Sbjct: 337 YNMPLAYLSTVGVSFF-ITCITLVYSMAHSFGESYRVGSTSGI-HAITVFCSWDYKVTQK 394
Query: 394 ETADNKYASITTSFKESIVDEQESNKEENI-HLTRFLRVLANFLIICCLCGSGYLIYFVV 452
+ + +I T KE + + Q + ++ R VL ++C G + V
Sbjct: 395 RASRLQQDNIRTRLKELLAEWQLRHSPRSVCGRLRQAAVLGLVWLLCLGTALGCAVAVHV 454
Query: 453 KRSQQFSKMQNVSWYERNE------VEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQL 506
FS+ S + + +V+ LL + P L +AALE +
Sbjct: 455 -----FSEFMIQSPEAAGQEAVLLVLPLVVGLLNLGAPYLCRVLAALEPHD--------- 500
Query: 507 GRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHP 566
+ +A+ ++ LKLA T+ HW
Sbjct: 501 --------SPVLEVYVAICRNLILKLAILGTL--CYHWLG------------------RR 532
Query: 567 ADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPS 626
V +G CWE VG E R V D ++ + L G+ + + +
Sbjct: 533 VGVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIIS---------EKKLKRRR 583
Query: 627 YAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVF 686
EFDI+ NVL LI+ Q + W+G ++P L + +++LL Y + +++++ R +
Sbjct: 584 KPEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPW 643
Query: 687 KASRSNNFYMGLLLLVLFL-SLLPVAYTIMSLPPSFDCGPFSGKNRMYD---VLQETIEN 742
AS + ++ LL FL + + + Y + + PS CGPF + MY+ V +E
Sbjct: 644 LASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEA 703
Query: 743 DFP--TFLGKIFAFLANPGLIIPAILLMFLAIYYLN 776
P ++L + +L + + + LA+ YLN
Sbjct: 704 AGPRVSWLPWVHRYLMENTFFVFLVSALLLAVIYLN 739
>gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens]
Length = 948
Score = 118 bits (295), Expect = 3e-26
Identities = 134/603 (22%), Positives = 246/603 (40%), Gaps = 109/603 (18%)
Query: 167 IATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKML---------MAKKW 217
I +R++P M +K R ++ V+K K KQ + L +++ +
Sbjct: 366 IKAIRNQPRTMEEK----RNLRKIVDKE-------KSKQTHRILQLNCCIQCLNSISRAY 414
Query: 218 VKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIP 277
+ K W+ +K I FG+SV SYF FLRW+ N+ F L F +IIP
Sbjct: 415 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 474
Query: 278 EVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEG--YIKYSALFYGYYNN---QRTIGW 332
+ + ++ + F+ L F G Y + + ++YG+Y N Q
Sbjct: 475 QFTVA---------------KKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSG 519
Query: 333 LRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGE--SDNFTFSFKMFTSWDYLI 390
Y + +AY + ++ SMA + + S T K+ WD+ +
Sbjct: 520 ASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGIT---KLIFCWDFTV 576
Query: 391 GNSETADNKYASITTSFKESIVDEQESNKEENIH--LTRFLRVLANFL------IICCLC 442
+ + K +++T +E++ + ++ N + + LTRF + ++ I CC
Sbjct: 577 THEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAA 636
Query: 443 GSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYH-PRTG 501
+Y++ + + +F K + + V+S + + P ++ +E Y PR
Sbjct: 637 -----VYYLAEYNLEFLKTHSNPGAVLL-LPFVVSCINLAVPCIYSMFRLVERYEMPRH- 689
Query: 502 LKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPR 561
++ L + N++ I+ + YY W
Sbjct: 690 ------EVYVLLIRNIFL--------------------KISIIGILCYY----W------ 713
Query: 562 PPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLE 621
L+ + CWET +G + RL + D + + + LG+FLR + M L+
Sbjct: 714 --LNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRR--IIGMQLITSLGLQ 769
Query: 622 AGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVP 681
EFDI+ NVL LI+ Q ++W+G F+ P L I ++ L Y + ++M + P
Sbjct: 770 -------EFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQP 822
Query: 682 HERVFKASRSNNFYMGLLLLVLFLSLL-PVAYTIMSLPPSFDCGPFSGKNRMYDVLQETI 740
+ ++AS+ F++ LL F +L +A TI + G+ M +L E I
Sbjct: 823 PSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRIITYLYWQITEGRKIMIRLLHEQI 882
Query: 741 END 743
N+
Sbjct: 883 INE 885
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 54.3 bits (129), Expect = 5e-07
Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 12/126 (9%)
Query: 70 RRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKR 129
RR++ R+R RE+ ++ERG+ E+ +G RK++ER + R REKE EEK KR
Sbjct: 63 RREREKRKREREKERKRERGKKEK--KGERKKEERERKKRR-----REKENKEGEEKEKR 115
Query: 130 QKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQE 189
+KK + +S G E +EE + EE+K+ + +K + RE ++
Sbjct: 116 KKKEKKERGRTSKEGKERERKEE-----RKREERKERERKKEEREKERERKERKKRERKQ 170
Query: 190 FVEKYE 195
EK E
Sbjct: 171 VGEKEE 176
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 6/142 (4%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R KR + E G +R +KE+ + + ++ R REE E+ER + ER
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEEL 153
E R+R ER + + K E+ R+EK ++++K R + E E
Sbjct: 155 --EKERERKERKKRERKQVGEKEEE----RKEKERKERKKRERNRKERKKERERKERRER 208
Query: 154 AQILEQVEEKKKLIATMRSKPW 175
+ ++ EE+KK R W
Sbjct: 209 KKERKKKEERKKERQKDRQTNW 230
Score = 50.4 bits (119), Expect = 7e-06
Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 6/124 (4%)
Query: 33 RRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAE 92
R +SK + E R+ +R ++ER R ++ ++R R+++GE+E E
Sbjct: 123 RGRTSKEGKERERKEERKREERKERERK--KEEREKERERKERKKRERKQVGEKEEERKE 180
Query: 93 RTCEGRRKRD----ERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESL 148
+ + R+KR+ ER +ER +R+KE ++EE+ K ++K R ++ G
Sbjct: 181 KERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRER 240
Query: 149 SEEE 152
E +
Sbjct: 241 KERK 244
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/162 (24%), Positives = 72/162 (44%), Gaps = 10/162 (6%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R S ++ + E +R ++ +K G G ++++ R++ R E +E E E+
Sbjct: 55 RESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEK 114
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGE--SLSEE 151
RK+ E+ +ER K KE R+EE+ + ++K R E +
Sbjct: 115 -----RKKKEK---KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166
Query: 152 ELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEK 193
E Q+ E+ EE+K+ R K K+ + RE +E E+
Sbjct: 167 ERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRER 208
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/164 (25%), Positives = 72/164 (43%), Gaps = 6/164 (3%)
Query: 6 KGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPS 65
K + E + + R K +R R ++ + + R +R +KE G
Sbjct: 53 KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEK 112
Query: 66 PGSPRRKQTGRRRHREELGEQERGE---AERTCEGRRKRDERASFQERTAAPKRE-KEIP 121
++++ R R +E E+ER E E E RK++ER +ER KRE K++
Sbjct: 113 EKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVG 172
Query: 122 RREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKK 165
+EE +R++K R + E E E + E+ +E+KK
Sbjct: 173 EKEE--ERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Score = 37.7 bits (86), Expect = 0.049
Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 19/142 (13%)
Query: 6 KGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPS 65
+G ++E R + + + + G R+ KR + E R ++ ++E+
Sbjct: 108 EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE-----RERKKEEREKERERKE 162
Query: 66 PGSPRRKQTGRR------RHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKE 119
RKQ G + + R+E ++ER ER E R +++ R +ER +R+KE
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE-RERKERRERKKERKKKEERKKE 221
Query: 120 IP-------RREEKSKRQKKPR 134
R +E+ KR++K R
Sbjct: 222 RQKDRQTNWREKERGKRERKER 243
Score = 35.0 bits (79), Expect = 0.32
Identities = 22/89 (24%), Positives = 45/89 (50%), Gaps = 1/89 (1%)
Query: 73 QTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKK 132
Q+ R E+ ++ G+ ER E +++R ER ++R +R++E ++E+K +R+K+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREK-RKREREKERKRERGKKEKKGERKKE 93
Query: 133 PRSSSLASSASGGESLSEEELAQILEQVE 161
R + E+E + E+ E
Sbjct: 94 ERERKKRRREKENKEGEEKEKRKKKEKKE 122
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/214 (22%), Positives = 102/214 (47%), Gaps = 14/214 (6%)
Query: 6 KGLKEEARGGVK---GRVKSGSPHTGDRLGR-RSSSKRALKAEG-TPGRRGAQRSQKERA 60
+G E G V+ G+V+ ++ G+ R + + EG + G R Q+ +
Sbjct: 135 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQM 194
Query: 61 GGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI 120
G + +Q G + + + E++ GE E E RK++E+ QE K+E+++
Sbjct: 195 GEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE---EQMRKQEEQMGEQEE-QVQKQEEQV 250
Query: 121 PRREEKSKRQKKP-RSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAK 179
++EE+ ++Q++ R + L ++E + EQ E+++ MR + M +
Sbjct: 251 QKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE---QMREQEEQMRE 307
Query: 180 KLTELREAQEFVEKYEGALGKGKGKQLYAYKMLM 213
+ ++RE +E + + E +GK + +Q++ K M
Sbjct: 308 QEEQMREQEEQMREQEEQMGK-QEEQMWEQKEQM 340
Score = 45.8 bits (107), Expect = 2e-04
Identities = 43/216 (19%), Positives = 90/216 (41%), Gaps = 16/216 (7%)
Query: 6 KGLKEEARGGVK---GRVKSGSPHTGDRLGR-RSSSKRALKAEGTPGRR-GAQRSQKERA 60
+G E G V+ G+V+ ++ G+ R + + EG G + G Q+E+
Sbjct: 149 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208
Query: 61 GGSPSPGSPRRKQTGR-----RRHREELGEQERG------EAERTCEGRRKRDERASFQE 109
G + +Q G R+ E++GEQE + ++ E RK++E+ QE
Sbjct: 209 GEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 110 RTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIAT 169
+ E+ + ++E+ + ++ EE++ + EQ+ E+++ +
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Query: 170 MRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQ 205
+ W +++ E +E E+ G + KQ
Sbjct: 329 QEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Score = 37.0 bits (84), Expect = 0.083
Identities = 31/138 (22%), Positives = 66/138 (47%), Gaps = 8/138 (5%)
Query: 70 RRKQTGR-----RRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRRE 124
+ +QTG R E++ EQE E+ E R+++E+ QE ++E+ ++E
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQMREQE-EQMREQEEQMGKQEEQMWEQKEQMWEQKE 345
Query: 125 EKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTEL 184
+ K++++ + +EE Q+ +Q E+ +K MR + M ++ ++
Sbjct: 346 QMWKQEEQMGEQEEQMQKQEEQVRKQEE--QMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 185 REAQEFVEKYEGALGKGK 202
E +E + + E +G+ K
Sbjct: 404 GEQKEQMREQEEQMGEQK 421
Score = 34.3 bits (77), Expect = 0.54
Identities = 30/139 (21%), Positives = 69/139 (49%), Gaps = 22/139 (15%)
Query: 70 RRKQTGRRRHREELGEQERG---EAERTCEGRR---KRDERASFQERTAAPKREKEIPRR 123
R ++ R E++G+QE + E+ E + K++E+ QE K+E+++ ++
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ-KQEEQVRKQ 371
Query: 124 EEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTE 183
EE+ ++Q++ EE++ + EQ+ E+K+ + + + M ++ +
Sbjct: 372 EEQMRKQEEQMRKQ------------EEQMRKQEEQMGEQKEQMGEQKEQ---MREQEEQ 416
Query: 184 LREAQEFVEKYEGALGKGK 202
+ E +E + K E +G+ K
Sbjct: 417 MGEQKEQMRKQEEHMGEQK 435
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 2/106 (1%)
Query: 30 RLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERG 89
R ++ KR K G R+ + ++ R+K+ ++R +E E+ERG
Sbjct: 95 RKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERG 154
Query: 90 EAERTCEGRRKRDERASFQERTAAP-KREKEIPRREEKSKRQKKPR 134
+ ER +RK++ER +ER K+E+E R E+ K +KK R
Sbjct: 155 KRERK-RKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/192 (24%), Positives = 78/192 (40%), Gaps = 21/192 (10%)
Query: 32 GRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEA 91
G++ KR + G R + +K+R RRK+ ++ RE ++RG
Sbjct: 59 GKKEKKKRKKRERGKERERKRKEREKQR---KERREKERRKRKKEKKKRE---RKQRGRR 112
Query: 92 ERTCEGRRKRDERASFQ------------ERTAAPKREKEIPRREEKSKRQKKPRSSSLA 139
ER + RK ER + Q +R KREKE +RE K K++KK
Sbjct: 113 ERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREK-K 171
Query: 140 SSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALG 199
+ E E E + E+ +E+KK + K +K ++Q F E A
Sbjct: 172 RERNRKERKKERERKERRERKKERKK--ERRKKKERKKDRKTDRQTDSQVFRPLRESAFN 229
Query: 200 KGKGKQLYAYKM 211
+ ++ Y++
Sbjct: 230 RVTVTGVFRYRI 241
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/110 (29%), Positives = 54/110 (49%), Gaps = 10/110 (9%)
Query: 33 RRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPR-RKQTGRRRHREELGEQER--- 88
RR KR + E R ++ +K+R G R RK+ R + R+E E+ER
Sbjct: 40 RREREKRKREREKERKRERGKKEKKKRK--KRERGKERERKRKEREKQRKERREKERRKR 97
Query: 89 ----GEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPR 134
+ ER GRR+R ++ +ER K+ +E R++ + K+++K R
Sbjct: 98 KKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/109 (22%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 26 HTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGE 85
H +R S ++ + E +R ++ +K G +K+ +R+ RE E
Sbjct: 24 HISKPCTQRESERKKERREREKRKREREKERKRERG---------KKEKKKRKKRERGKE 74
Query: 86 QERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPR 134
+ER ER + + +R++ +++ + K+ RRE K K+++K R
Sbjct: 75 RERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/99 (28%), Positives = 51/99 (51%), Gaps = 6/99 (6%)
Query: 70 RRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREE---K 126
RR++ R+R RE+ ++ERG+ E+ +RK+ ER +ER + ++ RRE+ K
Sbjct: 40 RREREKRKREREKERKRERGKKEKK---KRKKRERGKERERKRKEREKQRKERREKERRK 96
Query: 127 SKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKK 165
K++KK R + +E + +Q E+K+
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135
Score = 39.7 bits (91), Expect = 0.013
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 5/134 (3%)
Query: 6 KGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGT-PGRRGAQRSQKERAGGSP 64
K KE + R K + GRR K+ + E ++ +R +K+R
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 65 SPGSPRRKQTGRRRHREELGEQERGEA--ERTCEGRRKRDERASFQERTAAPKREKEIPR 122
R K+ G+R + + ++E E ER + R+K ER +ER +R+KE +
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRER--KKERKKERRK 201
Query: 123 REEKSKRQKKPRSS 136
++E+ K +K R +
Sbjct: 202 KKERKKDRKTDRQT 215
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 47.8 bits (112), Expect = 5e-05
Identities = 47/185 (25%), Positives = 80/185 (43%), Gaps = 17/185 (9%)
Query: 21 KSGSPHTGDRLGRRSSSK---RALKAEGTPGR-RGAQRSQKERAGGSPSPGSPRRKQTGR 76
+ SP +R R+ + R + +P + R RS+ R GGS S R K R
Sbjct: 11 RDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAER 70
Query: 77 -RRHREELGEQERG----EAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQK 131
RRH+E ++ER + +R +G R+ +R + + +P R K+ R K + K
Sbjct: 71 ERRHKERERDKERDRNKKDRDRDKDGHRRDKDR---KRSSLSPGRGKDFKSR--KDRDSK 125
Query: 132 KPRSSSLASSASGGESLSEEEL---AQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQ 188
K + LS EEL + E+ E K K ++ + + ++ E+ E Q
Sbjct: 126 KDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQ 185
Query: 189 EFVEK 193
+E+
Sbjct: 186 RMLEE 190
Score = 35.0 bits (79), Expect = 0.32
Identities = 53/219 (24%), Positives = 89/219 (40%), Gaps = 34/219 (15%)
Query: 9 KEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRG----AQRSQKERAGGSP 64
++ RGG + R +S S + +R R +R + + R R K+R S
Sbjct: 50 RDRRRGGSRSRSRSRSK-SAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSL 108
Query: 65 SPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRRE 124
SPG + ++ + R ++ E E G+ ++ + + S +E A K E+E
Sbjct: 109 SPGRGKDFKSRKDRDSKKDEEDEHGD-------KKPKAQPLSLEELLAKKKAEEEA---- 157
Query: 125 EKSKRQKKPRSSSLA---SSASGGESLSEEELAQILEQVEEKKKLIATMRSKPW--PMAK 179
+ KP+ S A + A EE ++LE+ +K+K + K P +
Sbjct: 158 -----EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQER 212
Query: 180 KLTELREAQEFV----EKYEGAL----GKGKGKQLYAYK 210
+ E RE E E EG K K K+L+A K
Sbjct: 213 ERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIK 251
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 47.0 bits (110), Expect = 8e-05
Identities = 38/164 (23%), Positives = 80/164 (48%), Gaps = 11/164 (6%)
Query: 85 EQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASG 144
E++ E E+ E KR E +E+ ++E ++ R+EEK + Q++
Sbjct: 350 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ 409
Query: 145 GESLSEEE--LAQILEQVEEKKKLIATMRSKPWPMAKKLTE----LREAQEFVEKYEGAL 198
E + E+E + + E+++E+++ + K KK+ E +RE +E +++ E +
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 469
Query: 199 GKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIE 242
G+ +GK + + M ++ K +R + + Q E KI++ E
Sbjct: 470 GEQEGK-MCEQEAKMQEQEEKMRRQEEKIREQ----EKKIREQE 508
Score = 43.9 bits (102), Expect = 7e-04
Identities = 46/177 (25%), Positives = 86/177 (48%), Gaps = 14/177 (7%)
Query: 72 KQTGRRRHREELGEQERGEAERTCEGR-RKRDERASFQERTAAPKREKEIPRREEKSKRQ 130
+Q + R+E QER E + E + R+++E+ QE K EK RR+E+ +
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM--RRQEEMMWE 341
Query: 131 KKPRSSSLASSASGGESLSE-EELAQILEQVEEKKKLIATMRSKPWPMAKKLTE----LR 185
K+ + L E + E EE Q E++ E++K +K W +K+ E +R
Sbjct: 342 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR 400
Query: 186 EAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIE 242
E +E +++ E +G+ + K ++ + M ++ K +R + + Q E KI++ E
Sbjct: 401 EQEEMMQEQEEKMGEQEEK-MWEQEEEMQEQEEKMRRQEEKIREQ----EKKIREQE 452
Score = 38.9 bits (89), Expect = 0.022
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 10/128 (7%)
Query: 71 RKQTGRRRHREEL---GEQERGEAE-RTCEGRRKRDERASFQERTAAPKREKEIPRREEK 126
R+Q + R +EE+ E++ GE E + CE + A QE+ +R++E R +EK
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQEGKMCE------QEAKMQEQEEKMRRQEEKIREQEK 502
Query: 127 SKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELRE 186
R+++ + E E+ ++ EQ E+ ++ MR + M ++ LR+
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Query: 187 AQEFVEKY 194
+E ++++
Sbjct: 563 QEEKMQEH 570
Score = 35.8 bits (81), Expect = 0.19
Identities = 36/184 (19%), Positives = 84/184 (45%), Gaps = 16/184 (8%)
Query: 71 RKQTGRRRHREEL---GEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKS 127
R+Q + R +EE+ E++ GE E + ++ QE+ +R++E R +EK
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEE-----KMWEQEEEMQEQEEKMRRQEEKIREQEKK 447
Query: 128 KRQKKPRSSSLASSASGGESLSEEELAQILEQ---VEEKKKLIATMRSKPWPMAKKLTE- 183
R+++ + E E+ ++ EQ ++E+++ + K KK+ E
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 184 ---LREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKD 240
+RE +E +++ E + + + K + + M ++ K +R + + Q + + +
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Query: 241 IESH 244
++ H
Sbjct: 567 MQEH 570
Score = 35.0 bits (79), Expect = 0.32
Identities = 32/143 (22%), Positives = 66/143 (46%), Gaps = 26/143 (18%)
Query: 71 RKQTGRRRHREELGEQERGEAE-----RTCEGRRKRDERASFQERTAAPKREK------- 118
R+Q +R+ E++ EQE+ + + R E R+++E+ QE + EK
Sbjct: 360 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 419
Query: 119 ------EIPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRS 172
E+ +EEK +RQ++ E + E+E +++++ EEK M
Sbjct: 420 MWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--EMMQEQEEK------MGE 471
Query: 173 KPWPMAKKLTELREAQEFVEKYE 195
+ M ++ +++E +E + + E
Sbjct: 472 QEGKMCEQEAKMQEQEEKMRRQE 494
>gi|50409691 SRp25 nuclear protein isoform 4 [Homo sapiens]
Length = 338
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/217 (25%), Positives = 88/217 (40%), Gaps = 33/217 (15%)
Query: 10 EEARGGVKG----RVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPS 65
E+ARGG+ G R + H G R +RS S+ + G+ R+ R R S S
Sbjct: 106 EKARGGLSGPQGGRARGAMAHVGSR--KRSRSRSRSRGRGSEKRKKKSRKDTSR-NCSAS 162
Query: 66 PGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREE 125
R KQ RRR R + + + +++ K + RR++
Sbjct: 163 TSQERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDK----RRKK 218
Query: 126 KSKRQKKPRSSSLASSASGGESL------------SEEELAQILEQVEEKKKLIATMRSK 173
K KR+K + + A E+L EEE +L +E+K I M+
Sbjct: 219 KKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVL--TDEQKSRIQAMK-- 274
Query: 174 PWPMAKKLTELREA--QEFVEKYEG--ALGKGKGKQL 206
PM K+ + R++ ++ V+ G L KG G+ L
Sbjct: 275 --PMTKEEWDARQSIIRKVVDPETGRTRLIKGDGEVL 309
Score = 35.8 bits (81), Expect = 0.19
Identities = 49/189 (25%), Positives = 77/189 (40%), Gaps = 30/189 (15%)
Query: 12 ARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTP-------GRRGAQRSQKERAGGSP 64
AR G G GS G L R +S+ A + E + R G Q RA G+
Sbjct: 68 ARDGTWGVRTKGS---GAALPSRPASRAAPRPEASSPPLPLEKARGGLSGPQGGRARGAM 124
Query: 65 SPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRRE 124
+ R++ R R R R E R+K+ + + + +A+ +E R +
Sbjct: 125 AHVGSRKRSRSRSRSRG-----------RGSEKRKKKSRKDTSRNCSASTSQE----RSK 169
Query: 125 EKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKL--- 181
+K++R+ + SSS +SS+S S S + +K+ R K KKL
Sbjct: 170 QKARRRTRSSSSS-SSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDKRRKKKKKRKKLKKK 228
Query: 182 -TELREAQE 189
E EAQ+
Sbjct: 229 GKEKAEAQQ 237
>gi|50409707 SRp25 nuclear protein isoform 2 [Homo sapiens]
Length = 341
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/217 (25%), Positives = 88/217 (40%), Gaps = 33/217 (15%)
Query: 10 EEARGGVKG----RVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPS 65
E+ARGG+ G R + H G R +RS S+ + G+ R+ R R S S
Sbjct: 106 EKARGGLSGPQGGRARGAMAHVGSR--KRSRSRSRSRGRGSEKRKKKSRKDTSR-NCSAS 162
Query: 66 PGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREE 125
R KQ RRR R + + + +++ K + RR++
Sbjct: 163 TSQERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDK----RRKK 218
Query: 126 KSKRQKKPRSSSLASSASGGESL------------SEEELAQILEQVEEKKKLIATMRSK 173
K KR+K + + A E+L EEE +L +E+K I M+
Sbjct: 219 KKKRKKLKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVL--TDEQKSRIQAMK-- 274
Query: 174 PWPMAKKLTELREA--QEFVEKYEG--ALGKGKGKQL 206
PM K+ + R++ ++ V+ G L KG G+ L
Sbjct: 275 --PMTKEEWDARQSIIRKVVDPETGRTRLIKGDGEVL 309
Score = 35.8 bits (81), Expect = 0.19
Identities = 49/189 (25%), Positives = 77/189 (40%), Gaps = 30/189 (15%)
Query: 12 ARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTP-------GRRGAQRSQKERAGGSP 64
AR G G GS G L R +S+ A + E + R G Q RA G+
Sbjct: 68 ARDGTWGVRTKGS---GAALPSRPASRAAPRPEASSPPLPLEKARGGLSGPQGGRARGAM 124
Query: 65 SPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRRE 124
+ R++ R R R R E R+K+ + + + +A+ +E R +
Sbjct: 125 AHVGSRKRSRSRSRSRG-----------RGSEKRKKKSRKDTSRNCSASTSQE----RSK 169
Query: 125 EKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKL--- 181
+K++R+ + SSS +SS+S S S + +K+ R K KKL
Sbjct: 170 QKARRRTRSSSSS-SSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDKRRKKKKKRKKLKKK 228
Query: 182 -TELREAQE 189
E EAQ+
Sbjct: 229 GKEKAEAQQ 237
>gi|239758151 PREDICTED: hypothetical protein XP_002346314 [Homo
sapiens]
Length = 321
Score = 46.2 bits (108), Expect = 1e-04
Identities = 40/144 (27%), Positives = 67/144 (46%), Gaps = 10/144 (6%)
Query: 9 KEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGS 68
++ A G K R G ++ RR A A+ G G ++ QK RA G+ G
Sbjct: 156 QKAATAGAKSRGGGVRSRGGKKIRRRGQKAAAAGAKSCGG--GGKKPQKARAVGARRRGW 213
Query: 69 PRRKQTGRRRHR---EELGEQERGEAERTCEGRRKRDERASFQ--ERTAAPKREKEIPRR 123
+ ++ G++ E+ G++ R + E+ + R+R ++A+ ER P+R+K
Sbjct: 214 KKLRRRGKKAAAAGGEKAGKKLRQQGEKGRKKPRRRGQKAAAAGGERCKKPRRQK---AA 270
Query: 124 EEKSKRQKKPRSSSLASSASGGES 147
+K KKPR L S+ G ES
Sbjct: 271 AVSAKSPKKPRRRVLNSARLGAES 294
Score = 37.7 bits (86), Expect = 0.049
Identities = 35/153 (22%), Positives = 63/153 (41%), Gaps = 23/153 (15%)
Query: 9 KEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGS 68
+ R G + + + +G R+ R R G + +R QK G+ S G
Sbjct: 115 ESSTRSGPRRCLSQDASRSGSRVCRSRPQTRG------GGGKKPRRGQKAATAGAKSRGG 168
Query: 69 PRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQ--------------ERTAAP 114
R + G++ R G++ ++C G K+ ++A ++ AA
Sbjct: 169 GVRSRGGKKIRRR--GQKAAAAGAKSCGGGGKKPQKARAVGARRRGWKKLRRRGKKAAAA 226
Query: 115 KREKEIPR-REEKSKRQKKPRSSSLASSASGGE 146
EK + R++ K +KKPR ++A+GGE
Sbjct: 227 GGEKAGKKLRQQGEKGRKKPRRRGQKAAAAGGE 259
Score = 32.7 bits (73), Expect = 1.6
Identities = 29/96 (30%), Positives = 40/96 (41%), Gaps = 6/96 (6%)
Query: 6 KGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQ-RSQKERAGGSP 64
+G K A GG K K G++ GR+ +R KA G R + R QK A +
Sbjct: 219 RGKKAAAAGGEKAGKK--LRQQGEK-GRKKPRRRGQKAAAAGGERCKKPRRQKAAAVSAK 275
Query: 65 SPGSPRRK--QTGRRRHREELGEQERGEAERTCEGR 98
SP PRR+ + R Q RG+ + R
Sbjct: 276 SPKKPRRRVLNSARLGAESRKNPQRRGQKSMAAKSR 311
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/204 (25%), Positives = 88/204 (43%), Gaps = 14/204 (6%)
Query: 3 HQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSK-RALKAEGTPGRRGAQRSQKERAG 61
HQ + L E R G+ + H R R K RAL+ GRR +ER G
Sbjct: 364 HQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQ----GRRAWAAQVEERRG 419
Query: 62 GSPSPGSPRRKQTGRRRHREELGEQERGE-AERTCEGRRKRDERASFQERTAAPKREKEI 120
G R+ RR+ + E E+ R E AER RR+R ERA+ ++R ++E+ +
Sbjct: 420 RR---GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 476
Query: 121 PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK 180
+REE + ++ A + + Q+ EK++L R++ + +
Sbjct: 477 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL---QREKRELSRAERARHEALLQG 533
Query: 181 LT--ELREAQEFVEKYEGALGKGK 202
T + +E + E +LG+ +
Sbjct: 534 RTRQQRQEREGLRSSLEASLGRAQ 557
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/204 (25%), Positives = 88/204 (43%), Gaps = 14/204 (6%)
Query: 3 HQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSK-RALKAEGTPGRRGAQRSQKERAG 61
HQ + L E R G+ + H R R K RAL+ GRR +ER G
Sbjct: 366 HQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQ----GRRAWAAQVEERRG 421
Query: 62 GSPSPGSPRRKQTGRRRHREELGEQERGE-AERTCEGRRKRDERASFQERTAAPKREKEI 120
G R+ RR+ + E E+ R E AER RR+R ERA+ ++R ++E+ +
Sbjct: 422 RR---GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 478
Query: 121 PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK 180
+REE + ++ A + + Q+ EK++L R++ + +
Sbjct: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL---QREKRELSRAERARHEALLQG 535
Query: 181 LT--ELREAQEFVEKYEGALGKGK 202
T + +E + E +LG+ +
Sbjct: 536 RTRQQRQEREGLRSSLEASLGRAQ 559
Score = 30.8 bits (68), Expect = 6.0
Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 9/108 (8%)
Query: 801 KSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEET-------TPPSASQSQAMDKKAQG 853
+S + G A ++E K A + ++ +EE +P +A+ + A A
Sbjct: 142 RSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPS 201
Query: 854 PGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKSA 901
G+S+S S +LPAS +R P S A +Q P S +G+ +
Sbjct: 202 AGSSSSCSSASLPASPAPRAARKASPSPSS--ARTQPPPAGSRTGRKS 247
>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/204 (25%), Positives = 88/204 (43%), Gaps = 14/204 (6%)
Query: 3 HQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSK-RALKAEGTPGRRGAQRSQKERAG 61
HQ + L E R G+ + H R R K RAL+ GRR +ER G
Sbjct: 366 HQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQ----GRRAWAAQVEERRG 421
Query: 62 GSPSPGSPRRKQTGRRRHREELGEQERGE-AERTCEGRRKRDERASFQERTAAPKREKEI 120
G R+ RR+ + E E+ R E AER RR+R ERA+ ++R ++E+ +
Sbjct: 422 RR---GREEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNL 478
Query: 121 PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKK 180
+REE + ++ A + + Q+ EK++L R++ + +
Sbjct: 479 KQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQL---QREKRELSRAERARHEALLQG 535
Query: 181 LT--ELREAQEFVEKYEGALGKGK 202
T + +E + E +LG+ +
Sbjct: 536 RTRQQRQEREGLRSSLEASLGRAQ 559
Score = 30.8 bits (68), Expect = 6.0
Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 9/108 (8%)
Query: 801 KSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEET-------TPPSASQSQAMDKKAQG 853
+S + G A ++E K A + ++ +EE +P +A+ + A A
Sbjct: 142 RSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPS 201
Query: 854 PGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKSA 901
G+S+S S +LPAS +R P S A +Q P S +G+ +
Sbjct: 202 AGSSSSCSSASLPASPAPRAARKASPSPSS--ARTQPPPAGSRTGRKS 247
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/154 (27%), Positives = 71/154 (46%), Gaps = 14/154 (9%)
Query: 46 TPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERA 105
TPG Q Q E+A + K RR E ++E E +R E RR+++E
Sbjct: 712 TPGPALEQLQQLEKAKAA--------KLEQERREAEMRAKREEEERKRQEELRRQQEEIL 763
Query: 106 SFQERTAAPKREKE--IPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILE----Q 159
Q+ +RE+E R++E++ R+++ + +L E +EE + LE +
Sbjct: 764 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 823
Query: 160 VEEKKKLIATMRSKPWPMAKKLTELREAQEFVEK 193
EE++K +R + AK E EAQ +E+
Sbjct: 824 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 857
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/159 (20%), Positives = 65/159 (40%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R + L+ + R+ + + R + R ++ RR REE Q++ EA R
Sbjct: 756 RRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALR 815
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEEL 153
E RR+ +E QE + E+ E+ + Q++ + L EEE
Sbjct: 816 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 875
Query: 154 AQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVE 192
+ E +++K + R + ++L + ++ Q+ +
Sbjct: 876 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 914
Score = 34.7 bits (78), Expect = 0.41
Identities = 38/185 (20%), Positives = 75/185 (40%), Gaps = 8/185 (4%)
Query: 29 DRLGRRSSSK--RALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQ 86
+ L RR + R + + RR + ++++ + RR++ RR +EEL +
Sbjct: 777 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 836
Query: 87 ERGEAERTCEG-----RRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASS 141
+ EA + RR + R +E A + E+E +R+E +++K
Sbjct: 837 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 896
Query: 142 ASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLT-ELREAQEFVEKYEGALGK 200
L +++ Q L Q++ +S + T L E Q+ E+ E L +
Sbjct: 897 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 956
Query: 201 GKGKQ 205
+ +Q
Sbjct: 957 EQRRQ 961
Score = 32.3 bits (72), Expect = 2.1
Identities = 26/118 (22%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 72 KQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQK 131
++ R RH EE +++ E +R E R+R ++ R ++++++ + + S
Sbjct: 864 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTW 923
Query: 132 KPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQE 189
+S++ A + SL+E Q LE+ E +++L R + + K L + ++ Q+
Sbjct: 924 GQQSNTTACQSQATLSLAE---IQKLEE-ERERQLREEQRRQQRELMKALQQQQQQQQ 977
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/154 (27%), Positives = 71/154 (46%), Gaps = 14/154 (9%)
Query: 46 TPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERA 105
TPG Q Q E+A + K RR E ++E E +R E RR+++E
Sbjct: 739 TPGPALEQLQQLEKAKAA--------KLEQERREAEMRAKREEEERKRQEELRRQQEEIL 790
Query: 106 SFQERTAAPKREKE--IPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILE----Q 159
Q+ +RE+E R++E++ R+++ + +L E +EE + LE +
Sbjct: 791 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 850
Query: 160 VEEKKKLIATMRSKPWPMAKKLTELREAQEFVEK 193
EE++K +R + AK E EAQ +E+
Sbjct: 851 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 884
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/159 (20%), Positives = 65/159 (40%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R + L+ + R+ + + R + R ++ RR REE Q++ EA R
Sbjct: 783 RRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALR 842
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEEL 153
E RR+ +E QE + E+ E+ + Q++ + L EEE
Sbjct: 843 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 902
Query: 154 AQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVE 192
+ E +++K + R + ++L + ++ Q+ +
Sbjct: 903 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 941
Score = 34.7 bits (78), Expect = 0.41
Identities = 38/185 (20%), Positives = 75/185 (40%), Gaps = 8/185 (4%)
Query: 29 DRLGRRSSSK--RALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQ 86
+ L RR + R + + RR + ++++ + RR++ RR +EEL +
Sbjct: 804 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863
Query: 87 ERGEAERTCEG-----RRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASS 141
+ EA + RR + R +E A + E+E +R+E +++K
Sbjct: 864 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 923
Query: 142 ASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLT-ELREAQEFVEKYEGALGK 200
L +++ Q L Q++ +S + T L E Q+ E+ E L +
Sbjct: 924 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 983
Query: 201 GKGKQ 205
+ +Q
Sbjct: 984 EQRRQ 988
Score = 32.3 bits (72), Expect = 2.1
Identities = 26/118 (22%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 72 KQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQK 131
++ R RH EE +++ E +R E R+R ++ R ++++++ + + S
Sbjct: 891 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTW 950
Query: 132 KPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQE 189
+S++ A + SL+E Q LE+ E +++L R + + K L + ++ Q+
Sbjct: 951 GQQSNTTACQSQATLSLAE---IQKLEE-ERERQLREEQRRQQRELMKALQQQQQQQQ 1004
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/154 (27%), Positives = 71/154 (46%), Gaps = 14/154 (9%)
Query: 46 TPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERA 105
TPG Q Q E+A + K RR E ++E E +R E RR+++E
Sbjct: 718 TPGPALEQLQQLEKAKAA--------KLEQERREAEMRAKREEEERKRQEELRRQQEEIL 769
Query: 106 SFQERTAAPKREKE--IPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILE----Q 159
Q+ +RE+E R++E++ R+++ + +L E +EE + LE +
Sbjct: 770 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829
Query: 160 VEEKKKLIATMRSKPWPMAKKLTELREAQEFVEK 193
EE++K +R + AK E EAQ +E+
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/159 (20%), Positives = 65/159 (40%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R + L+ + R+ + + R + R ++ RR REE Q++ EA R
Sbjct: 762 RRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALR 821
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEEL 153
E RR+ +E QE + E+ E+ + Q++ + L EEE
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 881
Query: 154 AQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVE 192
+ E +++K + R + ++L + ++ Q+ +
Sbjct: 882 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Score = 34.7 bits (78), Expect = 0.41
Identities = 38/185 (20%), Positives = 75/185 (40%), Gaps = 8/185 (4%)
Query: 29 DRLGRRSSSK--RALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQ 86
+ L RR + R + + RR + ++++ + RR++ RR +EEL +
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Query: 87 ERGEAERTCEG-----RRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASS 141
+ EA + RR + R +E A + E+E +R+E +++K
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 142 ASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLT-ELREAQEFVEKYEGALGK 200
L +++ Q L Q++ +S + T L E Q+ E+ E L +
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 962
Query: 201 GKGKQ 205
+ +Q
Sbjct: 963 EQRRQ 967
Score = 32.3 bits (72), Expect = 2.1
Identities = 26/118 (22%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 72 KQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQK 131
++ R RH EE +++ E +R E R+R ++ R ++++++ + + S
Sbjct: 870 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTW 929
Query: 132 KPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQE 189
+S++ A + SL+E Q LE+ E +++L R + + K L + ++ Q+
Sbjct: 930 GQQSNTTACQSQATLSLAE---IQKLEE-ERERQLREEQRRQQRELMKALQQQQQQQQ 983
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/154 (27%), Positives = 71/154 (46%), Gaps = 14/154 (9%)
Query: 46 TPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERA 105
TPG Q Q E+A + K RR E ++E E +R E RR+++E
Sbjct: 718 TPGPALEQLQQLEKAKAA--------KLEQERREAEMRAKREEEERKRQEELRRQQEEIL 769
Query: 106 SFQERTAAPKREKE--IPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILE----Q 159
Q+ +RE+E R++E++ R+++ + +L E +EE + LE +
Sbjct: 770 RRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE 829
Query: 160 VEEKKKLIATMRSKPWPMAKKLTELREAQEFVEK 193
EE++K +R + AK E EAQ +E+
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/159 (20%), Positives = 65/159 (40%)
Query: 34 RSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAER 93
R + L+ + R+ + + R + R ++ RR REE Q++ EA R
Sbjct: 762 RRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALR 821
Query: 94 TCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEEL 153
E RR+ +E QE + E+ E+ + Q++ + L EEE
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEE 881
Query: 154 AQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVE 192
+ E +++K + R + ++L + ++ Q+ +
Sbjct: 882 RKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ 920
Score = 34.7 bits (78), Expect = 0.41
Identities = 38/185 (20%), Positives = 75/185 (40%), Gaps = 8/185 (4%)
Query: 29 DRLGRRSSSK--RALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQ 86
+ L RR + R + + RR + ++++ + RR++ RR +EEL +
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Query: 87 ERGEAERTCEG-----RRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASS 141
+ EA + RR + R +E A + E+E +R+E +++K
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQ 902
Query: 142 ASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLT-ELREAQEFVEKYEGALGK 200
L +++ Q L Q++ +S + T L E Q+ E+ E L +
Sbjct: 903 QEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 962
Query: 201 GKGKQ 205
+ +Q
Sbjct: 963 EQRRQ 967
Score = 32.3 bits (72), Expect = 2.1
Identities = 26/118 (22%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 72 KQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQK 131
++ R RH EE +++ E +R E R+R ++ R ++++++ + + S
Sbjct: 870 EEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTW 929
Query: 132 KPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQE 189
+S++ A + SL+E Q LE+ E +++L R + + K L + ++ Q+
Sbjct: 930 GQQSNTTACQSQATLSLAE---IQKLEE-ERERQLREEQRRQQRELMKALQQQQQQQQ 983
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 44.7 bits (104), Expect = 4e-04
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 7/122 (5%)
Query: 16 VKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPG--SPRRKQ 73
+ R S S +G + R S S R + +R + A PS SP+RKQ
Sbjct: 327 ISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQ 386
Query: 74 TGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKP 133
+ R HR + E+ R + ERT + +R ER +E T KR++E REE+ Q +
Sbjct: 387 SPPR-HRSPMREKGRHDHERTSQSHDRRHER---REDTRG-KRDREKDSREEREYEQDQS 441
Query: 134 RS 135
S
Sbjct: 442 SS 443
Score = 43.5 bits (101), Expect = 9e-04
Identities = 29/86 (33%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 49 RRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQ 108
RR +R +++ P SP R Q GR +EL ER E R +RDERA +
Sbjct: 624 RRHGERDRRDNRERDQRPSSPIRHQ-GRN---DELERDERREERRVDRVDDRRDERARER 679
Query: 109 ERTAAPKREKEIPRREEKSKRQKKPR 134
+R RE+E R E+ + ++K R
Sbjct: 680 DRERERDRERERERERERDREREKER 705
Score = 37.0 bits (84), Expect = 0.083
Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 70 RRKQTGRRRHREELGEQERG-EAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSK 128
R K+ R R R+ ++ER E ER E R+R+ +ER +RE+E R E+++
Sbjct: 719 REKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR 778
Query: 129 RQKKPR 134
+ K R
Sbjct: 779 ERDKER 784
Score = 36.2 bits (82), Expect = 0.14
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 33 RRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAE 92
R +R L+ E R + +++R R ++ R R RE+ E+ER E E
Sbjct: 699 REREKERELERERAREREREREKERDRERDRDRDHD-RERERERERDREKEREREREERE 757
Query: 93 RTCEGRRKRD-ERASFQERTAAPKREKEIPRR-EEKSK 128
R E R+R+ ER +ER +E+E R E+K K
Sbjct: 758 RERERERERERERERERERARERDKERERQRDWEDKDK 795
Score = 35.8 bits (81), Expect = 0.19
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 8/144 (5%)
Query: 29 DRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQER 88
DR R +R GR + R RR + R R RE ++ER
Sbjct: 630 DRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRER 689
Query: 89 GEAERTCEGRRKRD-------ERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASS 141
E ER E R+R+ ERA +ER +R++E R + + +++ R
Sbjct: 690 -ERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKE 748
Query: 142 ASGGESLSEEELAQILEQVEEKKK 165
E E + E+ E+++
Sbjct: 749 REREREERERERERERERERERER 772
Score = 34.3 bits (77), Expect = 0.54
Identities = 24/96 (25%), Positives = 42/96 (43%)
Query: 70 RRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKR 129
R ++ R R RE+ E ER A R K +R ++R +RE+E R EK +
Sbjct: 691 RERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERE 750
Query: 130 QKKPRSSSLASSASGGESLSEEELAQILEQVEEKKK 165
+++ E E E + E+ +E+++
Sbjct: 751 REREERERERERERERERERERERERARERDKERER 786
Score = 33.9 bits (76), Expect = 0.70
Identities = 30/106 (28%), Positives = 49/106 (46%), Gaps = 12/106 (11%)
Query: 70 RRKQTGRRRHREELGEQERG-EAERTCEGRRKRD-ERASFQERTAAPKREKEIPRREEKS 127
R ++ R R R+ E+ER E ER E R+R+ ER ++R RE+E R ++
Sbjct: 687 RERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDRE 746
Query: 128 KRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSK 173
K +++ R E E E + E+ E+++ A R K
Sbjct: 747 KERERERE----------ERERERERERERERERERERERARERDK 782
Score = 33.9 bits (76), Expect = 0.70
Identities = 44/191 (23%), Positives = 78/191 (40%), Gaps = 40/191 (20%)
Query: 17 KGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQT-- 74
+ R S S T DR GR R + + + RR ++ KE+ S +R+QT
Sbjct: 872 ESRSLSPSHLTEDRQGRWKEEDRKPERKES-SRRYEEQELKEKV----SSVDKQREQTEI 926
Query: 75 ---GRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEI----------- 120
R R ++ +G + + E + + ++A Q++ K+E ++
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
Query: 121 -------PRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSK 173
P++ +K K +K R S G +S+EE AQ + KKK R+
Sbjct: 987 EDGQVFSPKKGQKKKSIEKKRKKS-----KGDSDISDEEAAQ-----QSKKK--RGPRTP 1034
Query: 174 PWPMAKKLTEL 184
P ++L E+
Sbjct: 1035 PITTKEELVEM 1045
Score = 31.2 bits (69), Expect = 4.6
Identities = 29/148 (19%), Positives = 63/148 (42%), Gaps = 13/148 (8%)
Query: 37 SKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCE 96
SK+ + EG+P R + + ++E + S + S K R + + Q E+
Sbjct: 822 SKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQ---ESRSLSP 878
Query: 97 GRRKRDERASFQERTAAPKREKEIPRREEKSKRQK-------KPRSSSLASSASGGESL- 148
D + ++E P+R++ R EE+ ++K + ++ L SS + +
Sbjct: 879 SHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDII 938
Query: 149 --SEEELAQILEQVEEKKKLIATMRSKP 174
+ E + ++ ++ K A ++ KP
Sbjct: 939 GHHQSEDRETSDRAHDENKKKAKIQKKP 966
Score = 30.4 bits (67), Expect = 7.8
Identities = 21/77 (27%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 56 QKERAGGSPSPGSPRRKQTGRRRHREELGEQER-GEAERTCEGRRKRDERASFQERTAA- 113
++ER R++ R R RE E+ER E ER E ++R+ + ++++
Sbjct: 738 ERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGR 797
Query: 114 -PKREKEIPRREEKSKR 129
+REK RE+++ R
Sbjct: 798 DDRREKREEIREDRNPR 814
>gi|41152097 DNA segment on chromosome X and Y (unique) 155
expressed sequence isoform 1 [Homo sapiens]
Length = 695
Score = 44.3 bits (103), Expect = 5e-04
Identities = 38/138 (27%), Positives = 69/138 (50%), Gaps = 13/138 (9%)
Query: 65 SPGSPRRKQTGRRRHRE-ELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRR 123
S S +++Q R++ +E E +E+ E+ E R++ +ER ++ + E+E R
Sbjct: 264 SDASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEER----KQKELEELERERKRE 319
Query: 124 EEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQV--EEKKKLIATMRSKPWPMAKKL 181
E+ KR++K R L + E L EE Q+ E++ EE+K L+A + + +L
Sbjct: 320 EKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAEL 379
Query: 182 ------TELREAQEFVEK 193
+LRE ++ EK
Sbjct: 380 LSRAKAVKLREQEQKEEK 397
Score = 38.9 bits (89), Expect = 0.022
Identities = 30/110 (27%), Positives = 48/110 (43%), Gaps = 12/110 (10%)
Query: 17 KGRVKSGSPHTGDRLGR-RSSSKRAL-------KAEGTPGRRGAQRSQKERAGGSPSPGS 68
KGR ++ DR R RS ++RA + E P ++ A + R + +
Sbjct: 585 KGRGRATGDGLADRHKRERSRARRASSREDGRPRKERRPHKKHAYKDDSPRRRSTSPDHT 644
Query: 69 PRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREK 118
R+ + RHR E + RG A R R+R ER+ R+ +P R +
Sbjct: 645 RSRRSHSKDRHRRERSRERRGSASRKHSRHRRRSERS----RSRSPSRHR 690
Score = 33.1 bits (74), Expect = 1.2
Identities = 30/117 (25%), Positives = 49/117 (41%), Gaps = 10/117 (8%)
Query: 29 DRLGRRSSSKRA-LKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRH-------R 80
D+ R S R +G R +RS+ RA S G PR+++ ++H R
Sbjct: 577 DKCNREPSKGRGRATGDGLADRHKRERSRARRAS-SREDGRPRKERRPHKKHAYKDDSPR 635
Query: 81 EELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSS 137
+ + R+ R R ER S + R +A ++ RR E+S+ + R S
Sbjct: 636 RRSTSPDHTRSRRSHSKDRHRRER-SRERRGSASRKHSRHRRRSERSRSRSPSRHRS 691
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,999,313
Number of Sequences: 37866
Number of extensions: 1653181
Number of successful extensions: 15628
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 528
Number of HSP's that attempted gapping in prelim test: 10659
Number of HSP's gapped (non-prelim): 3076
length of query: 906
length of database: 18,247,518
effective HSP length: 111
effective length of query: 795
effective length of database: 14,044,392
effective search space: 11165291640
effective search space used: 11165291640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.