BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapiens] (848 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 1705 0.0 gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 1697 0.0 gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 1391 0.0 gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 708 0.0 gi|118572606 hemicentin 1 [Homo sapiens] 167 3e-41 gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 162 1e-39 gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 162 1e-39 gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 155 2e-37 gi|19743806 roundabout 1 isoform b [Homo sapiens] 154 3e-37 gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 154 3e-37 gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 154 3e-37 gi|4506569 roundabout 1 isoform a [Homo sapiens] 154 3e-37 gi|224994173 roundabout 1 isoform d [Homo sapiens] 150 4e-36 gi|224994171 roundabout 1 isoform c [Homo sapiens] 150 4e-36 gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 150 4e-36 gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 150 4e-36 gi|110349719 titin isoform N2-A [Homo sapiens] 145 2e-34 gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 145 2e-34 gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 143 6e-34 gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 142 2e-33 gi|157311649 neogenin homolog 1 [Homo sapiens] 141 3e-33 gi|109150416 peroxidasin [Homo sapiens] 140 6e-33 gi|222352127 sidekick 2 [Homo sapiens] 139 1e-32 gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 139 1e-32 gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 137 3e-32 gi|119220552 sidekick 1 [Homo sapiens] 137 5e-32 gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 130 7e-30 gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 130 7e-30 gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 127 4e-29 gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 127 4e-29 >gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapiens] Length = 848 Score = 1705 bits (4416), Expect = 0.0 Identities = 848/848 (100%), Positives = 848/848 (100%) Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360 Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420 Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600 Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM 660 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM Sbjct: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM 660 Query: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV 720 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV Sbjct: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV 720 Query: 721 IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE 780 IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE Sbjct: 721 IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE 780 Query: 781 VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ 840 VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ Sbjct: 781 VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ 840 Query: 841 TKENESKA 848 TKENESKA Sbjct: 841 TKENESKA 848 >gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sapiens] Length = 858 Score = 1697 bits (4395), Expect = 0.0 Identities = 848/858 (98%), Positives = 848/858 (98%), Gaps = 10/858 (1%) Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK------- 353 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360 Query: 354 ---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 410 TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG Sbjct: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420 Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480 Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540 Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA Sbjct: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600 Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 650 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI Sbjct: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 660 Query: 651 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 710 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS Sbjct: 661 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720 Query: 711 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 770 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS Sbjct: 721 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 780 Query: 771 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 830 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE Sbjct: 781 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 840 Query: 831 VKTVPNDATQTKENESKA 848 VKTVPNDATQTKENESKA Sbjct: 841 VKTVPNDATQTKENESKA 858 >gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sapiens] Length = 761 Score = 1391 bits (3600), Expect = 0.0 Identities = 707/762 (92%), Positives = 710/762 (93%), Gaps = 37/762 (4%) Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60 Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120 Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180 Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240 Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300 Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360 Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420 Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV-- 598 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600 Query: 599 ---------------------------------QGEPSAPKLEGQMGEDGNSIKVNLIKQ 625 +GEPSAPKLEGQMGEDGNSIKVNLIKQ Sbjct: 601 PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ 660 Query: 626 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA Sbjct: 661 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 720 Query: 686 AHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 727 AHFVFRTSAQPTAIPA S T V +L LLL+ Sbjct: 721 AHFVFRTSAQPTAIPATLGGNSASYT--FVSLLFSAVTLLLL 760 >gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapiens] Length = 837 Score = 708 bits (1828), Expect = 0.0 Identities = 383/855 (44%), Positives = 538/855 (62%), Gaps = 33/855 (3%) Query: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61 L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK Sbjct: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60 Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121 + Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+ Sbjct: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118 Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181 +PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K Sbjct: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178 Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241 +DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P Sbjct: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238 Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301 EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE + Sbjct: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295 Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KTLDGHM 359 L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + + E K+LDG + Sbjct: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354 Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWE 418 V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK + Y+WE Sbjct: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414 Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 GN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S+NDFG YN Sbjct: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474 Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 CTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVPI Y+ + Sbjct: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 + V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S F+T P Sbjct: 535 KEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590 Query: 598 VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--WKPEIRLPSG 655 V+ EPS P + GQ G S K+++ KQDDGG+PI Y+V+YR+ E W E ++ Sbjct: 591 VR-EPSPPSIHGQ-PSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQGN 647 Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 715 DH++L+ L W YEV + A N+ G S+ + F +P I + +GL GA++ Sbjct: 648 KDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII--KDTLFNGLGLGAVI 705 Query: 716 GILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCG-KAGPGAKGKDMEEGKAAFSKDES 774 G+ + +L+LVV D++C+F+ +CGL MCI +CG K+G K K++EEGKAA+ KD S Sbjct: 706 GLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGS 765 Query: 775 KEPIVEVRTEEERTPNH-DGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKT 833 KEPIVE+RTE+ER NH DG EPNETTPLTEPEK P+ K E + P E+K Sbjct: 766 KEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPL--KEEDGKEALNPETIEIK- 822 Query: 834 VPNDATQTKENESKA 848 V ND Q+KE++SKA Sbjct: 823 VSNDIIQSKEDDSKA 837 >gi|118572606 hemicentin 1 [Homo sapiens] Length = 5635 Score = 167 bits (424), Expect = 3e-41 Identities = 127/428 (29%), Positives = 189/428 (44%), Gaps = 25/428 (5%) Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGED 134 ++ S L I +A + D G Y C T G +E VN+ + + + T EG Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNL 2213 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS-NNYLQIRGIKKTDEGTYRCEGRI 193 ++C+ PP +IWK KG V+ R +LS LQI +K+D Y C Sbjct: 2214 ISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASN 2273 Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253 +A ++QV + P + + G+S++L C+ +G P PT++W KDG Sbjct: 2274 VAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP 2332 Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--- 310 + + + E D+ L +K + +D Y+C+A N AG D L V A P I Sbjct: 2333 LIKAKGVE---ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN 2389 Query: 311 -TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369 EN + +E + V+LTCEASG P+PSITW +S L + + S R+ Sbjct: 2390 HRSPENISVVE-KNSVSLTCEASGIPLPSITWFKDGWPVS-----LSNSVRILSGGRM-- 2441 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITC 426 L L DAG+Y C N G++ + L V P + G V E V +TC Sbjct: 2442 LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 EV P I+W +DGQ L +I +L++T G Y C A + G Sbjct: 2502 EVTGNPVPEITWHKDGQPLQEDEAHHI----ISGGRFLQITNVQVPHTGRYTCLASSPAG 2557 Query: 487 QESLEFIL 494 +S F L Sbjct: 2558 HKSRSFSL 2565 Score = 160 bits (404), Expect = 6e-39 Identities = 121/473 (25%), Positives = 197/473 (41%), Gaps = 61/473 (12%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-V 110 I+WF N RI L + ++DAG Y CVV G E + + Sbjct: 2418 ITWFKDGWPVSLSNSVRIL-----SGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 +V + ++ +N + +E + + C+V + P I W HK + + + I+ Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW-HKDGQPLQEDEAHHIISG 2531 Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQ---ARQNIVNATA 225 +LQI ++ G Y C LA K +NV PTI + N + T Sbjct: 2532 GRFLQITNVQVPHTGRYTC----LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587 Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285 L +LVC+A +P T++W KDG +E + L I +++ Y Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIR---ILPGGRTLQILNAQEDNAGRY 2644 Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIP 337 C+A N+AGE +KV+ P I + + +++ +TL CEA P Sbjct: 2645 SCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704 Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397 S++W + + S D H+ + ++ +L +K Q +D G Y C ASN G+D Sbjct: 2705 SLSWYKDGQPLKS-----DDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAGEDELD 2757 Query: 398 MYLEVQYAPKLQGPVAVYTWE------------------GNQVNITCEVFAYPSATISWF 439 + +Q P Q WE N +++ CE A P T++W+ Sbjct: 2758 FDVNIQVPPSFQ-----KLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812 Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 +DG L SS+ K+ P L++ D G Y C AVN G++SL++ Sbjct: 2813 KDGHPLTSSD----KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQY 2861 Score = 158 bits (399), Expect = 2e-38 Identities = 114/420 (27%), Positives = 183/420 (43%), Gaps = 33/420 (7%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L + +A I D G Y CV G E + ++++++ + ++C Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAG-EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ 2126 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200 + PPT+ W G +LKK I + + L+I + D G Y CE +A G+ Sbjct: 2127 SDAIPPPTLTWLKDGHP-LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA-GKTE 2184 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260 K+ V + VPP I + T G ++L+C++ G P P + W K G + + Sbjct: 2185 -KNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG 2243 Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV---ENQT 317 I S QL I +K+D A Y C+A N AG +L+V+ +P IT + Sbjct: 2244 RVRILS-GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-----RVSSLTL 372 + + ++L CE G P P++TW DGH ++++ L L Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMK------------DGHPLIKAKGVEILDEGHILQL 2350 Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEV 428 K+I +D G Y+C A N G + L V P + G P + E N V++TCE Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410 Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 P +I+WF+DG P S ++++I + L + + D G Y C N G+E Sbjct: 2411 SGIPLPSITWFKDG--WPVSLSNSVRILS--GGRMLRLMQTTMEDAGQYTCVVRNAAGEE 2466 Score = 155 bits (393), Expect = 1e-37 Identities = 141/515 (27%), Positives = 215/515 (41%), Gaps = 47/515 (9%) Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137 S L I A +DAG Y CV G+ A +K+ ++ +P +E+ D I Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT---ALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096 Query: 138 V--CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195 C+ PP I W GR ++ + +R VLS+ LQI ++ D G Y C +A Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 ++ V+VPP I++ + + T N L C A+G P P ++W KD + Sbjct: 4155 GSSST--STKLTVHVPPRIRSTEG--HYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 KY ++ +L ++ V D Y C+A N AGE T+ L V P T + Sbjct: 4211 NLLG--KYT-AEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG 4267 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 ++ EQ+ L+C+A+G P+P +TW + I + +++GH S L ++ + Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH---------SELVIERV 4318 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPS 433 D+G Y+CTA N++G ++ V+ P +G E G + CEV P+ Sbjct: 4319 SKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPT 4378 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493 TI W R G + S+ ++ N A Y V D+ G+Y C A N G Sbjct: 4379 PTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDA----GDYTCVATNEAGVVERSMS 4433 Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW----HS-K 548 L T SP I +EP + GG IL +A W HS Sbjct: 4434 L----TLQSPPIITLEPVETVIN--------AGGKIILNCQATGEPQPTITWSRQGHSIS 4481 Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583 W D + I + E T A N G Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516 Score = 154 bits (388), Expect = 4e-37 Identities = 134/494 (27%), Positives = 214/494 (43%), Gaps = 54/494 (10%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P + +I V + C+ A +SW+ +G+ L + +++ N TL I Sbjct: 2681 PKEVKIKVNNTLTLECE-AYAIPSASLSWYK-DGQPLK-SDDHVNIAAN---GHTLQIKE 2734 Query: 86 ANIDDAGIYKCV---VTGEDGSESEATVNVKI---FQKLM-FKNAPTPQEFREGEDAVI- 137 A I D G Y CV + GED E + VN+++ FQKL N E +D +I Sbjct: 2735 AQISDTGRYTCVASNIAGED--ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIIN 2792 Query: 138 -----VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR 192 C+ ++ PPT+ W G + D I+ LQI K D G Y C Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHP-LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA- 2850 Query: 193 ILARGEINFK-DIQVIVNVPPTIQARQNIV--NATANLGQSVTLVCDAEGFPEPTMSWTK 249 + GE + + D++V+V PP I+ + + T + +S + C + G P P SW K Sbjct: 2851 VNEAGEDSLQYDVRVLV--PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908 Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309 DG+ + + D+ + F + L I D Y+C+AEN AG +L V P Sbjct: 2909 DGQPLLE---DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965 Query: 310 ITYVENQT-AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL---DGHMVVRSHA 365 + +++ + + ++LTCE SG P P ++W + + I TL G + A Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025 Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-----QGPVAVYTWEGN 420 +VS D GEY C A N G+ + L V P + + V EG Sbjct: 3026 KVS----------DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075 Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 V++ CE A P I+W+++G+++ S + I L + +D G Y C Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEI----LADGQMLHIKKAEVSDTGQYVCR 3131 Query: 481 AVNRIGQESLEFIL 494 A+N G++ F L Sbjct: 3132 AINVAGRDDKNFHL 3145 Score = 153 bits (387), Expect = 6e-37 Identities = 132/477 (27%), Positives = 206/477 (43%), Gaps = 34/477 (7%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P ++ + S C+ AG+ ++W + RI L I + Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPI-LTWLKDGVPVKANDNIRIEA-----GGKKLEIMS 1701 Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV--CDVVS 143 A D G Y CV T G E E V + + F + ++ C V Sbjct: 1702 AQEIDRGQYICVATSVAG-EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 S PPTI+W G+ +I ++D I+L+ L I + ++ G YRC A + K+ Sbjct: 1761 SPPPTIMWLKDGQ-LIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD--HKKE 1817 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 +V V+VPPTI++ + + V L C A G P P+++W KD + + + + K Sbjct: 1818 FEVTVHVPPTIKS-SGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK- 1875 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT---YVENQTAME 320 L I K D Y C+A N AGE I L V P + + N+T + Sbjct: 1876 -IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVL- 1933 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380 + V L C+A+G+P+P ITW R +S M + ++ + ++S Q +DA Sbjct: 1934 VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTS-----MTFLNRGQI--IDIESAQISDA 1986 Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437 G Y C A N+ G L+V AP + G VAV N V + CE P+ +++ Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVV--NNPVRLECEARGIPAPSLT 2044 Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 W +DG P S++SN + L +T +D G Y C AVN G++ + L Sbjct: 2045 WLKDGS--PVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDL 2098 Score = 152 bits (385), Expect = 1e-36 Identities = 120/476 (25%), Positives = 190/476 (39%), Gaps = 30/476 (6%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P ++ VG+ C G I+W L + +S + TL+I Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVS-----NPDGTLSIDQ 1230 Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE---GEDAVIVCDV 141 A DAGIY CV T G+ E+E T++V+ + P F+E + C Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPA 1290 Query: 142 VSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF 201 + PTI W H GR++ ++ I+ L I + D G Y C + Sbjct: 1291 KGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA--VNEAGTTE 1348 Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261 + + V+VPP I+ ++ + N + L Q L C+ EG P P + W KD Q+ + + Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQ 1408 Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAM 319 ++ L + + D Y C A N AG ++ V P I T N+ ++ Sbjct: 1409 TV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 L V L C+ G P P I W + G V R L LK+ + D Sbjct: 1466 VLNRDVALECQVKGTPFPDIHW------FKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATI 436 G Y CT SN G+ ++ + L + P ++G + + + + CE P I Sbjct: 1520 KGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAI 1579 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 +W++DGQ + SS+ + +Y YL + +D Y C N G F Sbjct: 1580 TWYKDGQPIMSSSQA---LY-IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631 Score = 150 bits (380), Expect = 4e-36 Identities = 125/475 (26%), Positives = 202/475 (42%), Gaps = 49/475 (10%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I+WF +G L N+ I ++ TL I NA D+AG Y CV T E G E Sbjct: 2607 ITWFK-DGTPLESNRN-IRIL---PGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYE 2660 Query: 112 VKIFQKLMFKN--------APTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKD 163 VK++ + +P + + + C+ + ++ W G+ LK D Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP--LKSD 2718 Query: 164 VRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN 222 + +N + LQI+ + +D G Y C +A GE D V + VPP+ Q I N Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIA-GEDEL-DFDVNIQVPPSFQKLWEIGN 2776 Query: 223 A--TANLGQS--------VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQL 272 T G++ ++L C+ P PT++W KDG + + K + L Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSD---KVLILPGGRVL 2833 Query: 273 TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL----EEQVTLT 328 I + D Y C+A N+AGE ++V P I + E+ + + Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE 2893 Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388 C +SG P P +W+ + + D H S+ R+ L + + Q TD G Y+C A Sbjct: 2894 CLSSGSPAPRNSWQKDGQPLLE-----DDHHKFLSNGRI--LQILNTQITDIGRYVCVAE 2946 Query: 389 NTIGQDSQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446 NT G + L V P + GP + + N +++TCEV +P +SW ++ Q + Sbjct: 2947 NTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006 Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 + + I P L++ +D G Y C A+N+ G+ +F L PS Sbjct: 3007 LNTNTLI----VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057 Score = 150 bits (378), Expect = 6e-36 Identities = 133/501 (26%), Positives = 206/501 (41%), Gaps = 52/501 (10%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I+W+ NG +T + + ++ + L I A + D G Y C G + Sbjct: 3091 ITWYK-NGRMITESTH-VEILAD---GQMLHIKKAEVSDTGQYVCRAINVAGRDD----- 3140 Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIV----------CDVVSSLPPTIIW--KHKGRDVI 159 K N P E VIV CD PPTI W HK + Sbjct: 3141 -----KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENS 3195 Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN 219 +VR I+ + LQI + +D G Y C + G+ K + + VPP++ + Sbjct: 3196 DSLEVR-ILSGGSKLQIARSQHSDSGNYTCIASNM-EGKAQ-KYYFLSIQVPPSVAGAEI 3252 Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279 + + LG++V LVC+A G P P + W KDG+ I E E+ S + S L I Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE-TERIRVSANGSTLNIYGALT 3311 Query: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAMEL-EEQVTLTCEASGDPI 336 +D +Y C+A N AGE+D +L V+ P I E + M L + + + C A+G P Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371 Query: 337 PSITWRTS--TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394 P I W + +SS + L V+R + Q +D Y C ASN G D Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIR---------IVRAQVSDVAVYTCVASNRAGVD 3422 Query: 395 SQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451 ++ L+V P + G + +G+ ++ C P+ +++W RDGQ L + Sbjct: 3423 NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL 3482 Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511 + + L++ D G Y C A N G+ S FIL + P ++ E Sbjct: 3483 TVSTH----GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI 3538 Query: 512 SSTAQVQFDEPEATGGVPILK 532 S + G+P K Sbjct: 3539 SVIVNNPLELTCIASGIPAPK 3559 Score = 148 bits (373), Expect = 2e-35 Identities = 125/483 (25%), Positives = 201/483 (41%), Gaps = 39/483 (8%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P++ ++ G+S C+V G ++W + I D L + N Sbjct: 2299 PTEIIVTRGKSISLECEVQG-IPPPTVTWMKDGHPLIKAKGVEIL-----DEGHILQLKN 2352 Query: 86 ANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKN-APTPQEFREGEDAVIVCDVVS 143 ++ D G Y CV G ++ + ++V ++ + +P E + C+ Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 P+I W G V L VR I+ L++ D G Y C R A E Sbjct: 2413 IPLPSITWFKDGWPVSLSNSVR-ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 + V+V PP I + + QSVTL C+ G P P ++W KDG+ + +ED+ + Sbjct: 2472 LSVLV--PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPL--QEDEAHH 2527 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--- 320 I S L I V Y C+A + AG + + L VF P I V + E Sbjct: 2528 IIS-GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586 Query: 321 --LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 L +L CEA P +ITW + L+ + +R +L + + Q Sbjct: 2587 VILNSPTSLVCEAYSYPPATITW-------FKDGTPLESNRNIRILPGGRTLQILNAQED 2639 Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------GPVAVYTWEGNQVNITCEVF 429 +AG Y C A+N G+ + ++V P + P V N + + CE + Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 A PSA++SW++DGQ L S ++ NI + L++ +D G Y C A N G++ Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNI----AANGHTLQIKEAQISDTGRYTCVASNIAGEDE 2755 Query: 490 LEF 492 L+F Sbjct: 2756 LDF 2758 Score = 144 bits (364), Expect = 3e-34 Identities = 118/473 (24%), Positives = 202/473 (42%), Gaps = 41/473 (8%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C+ AG+ I+W+ N +L ++ + + + I +A I DAGIYKCV Sbjct: 1942 CKAAGNPVPV-ITWYKDN--RLLSGSTSMTFL---NRGQIIDIESAQISDAGIYKCVAIN 1995 Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI------VCDVVSSLPPTIIWKHK 154 G+ ++F L AP+ V+ C+ P++ W Sbjct: 1996 SAGA-------TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048 Query: 155 GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTI 214 G V + ++ L + + +D G Y C + A GE +DI + V VPP I Sbjct: 2049 GSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQ-RDIDLRVYVPPNI 2106 Query: 215 QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI 274 + N + + Q+V L+C ++ P PT++W KDG + ++ S++ S L I Sbjct: 2107 MGEEQ--NVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG---LSISENRSVLKI 2161 Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ--VTLTCEAS 332 + D Y C A N AG+ + ++ ++ P I + T + + E ++L CE+S Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESS 2221 Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392 G P P++ W+ + ++ G + + S R L + + +DA Y C ASN G Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSM---GRVRILSGGR--QLQISIAEKSDAALYSCVASNVAG 2276 Query: 393 QDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448 + L+V P + P + G +++ CEV P T++W +DG P Sbjct: 2277 TAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGH--PLI 2334 Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 ++I + L++ +D G Y C AVN G ++ L PS Sbjct: 2335 KAKGVEILD--EGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385 Score = 144 bits (362), Expect = 4e-34 Identities = 103/414 (24%), Positives = 175/414 (42%), Gaps = 17/414 (4%) Query: 75 DDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGED 134 + +S L I + D G Y+C+ G+ A + + P GE Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGT-GRAQTFFDVSEPPPVIQVPNNVTVTPGER 536 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194 AV+ C ++S++ + W+ RDV L + R L+N L+++ +K D G Y C + Sbjct: 537 AVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHC--MVS 594 Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254 + G + + + V PP + N + G V+++C A G+P+P ++WT + I Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPK--NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI 652 Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314 +Y + D + L IK D Y C+A N AG L+ PK+ V+ Sbjct: 653 ---VGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 ++ + L + + C+ SG P P + W + + + + L ++ Sbjct: 709 SELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPL-------LGLLKIQE 761 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPS 433 Q DAG+Y C A N G+ + + L+V P +Q P V G+ V + C V YP Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPE 821 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 TI W R + S ++ + L + +D G Y C A N+ G+ Sbjct: 822 PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK 875 Score = 142 bits (357), Expect = 2e-33 Identities = 122/454 (26%), Positives = 183/454 (40%), Gaps = 32/454 (7%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139 L I A ++D G Y C+ + G + E V V + + + P + C Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643 Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199 + PP I W G + VR I+ YLQI D Y C +A G+ Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTANYTCVASNIA-GKT 3701 Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 ++ + VNVPP I+ + L +S L C AEG P P ++W KDG + Sbjct: 3702 T-REFILTVNVPPNIKGGPQ--SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 + ++ L I+ D Y+C+A N AG I L+V P I + Sbjct: 3759 RYSIL---ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV 3815 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 + Q TL CEA+G P PSI WR ++ + ++ + + ++ S SL + S D Sbjct: 3816 IVNVQTTLACEATGIPKPSINWR-KNGHLLNVDQNQNSYRLLSS----GSLVIISPSVDD 3870 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISW 438 Y CT +N G D +++ L VQ P + P + ITC P +I W Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHW 3930 Query: 439 FRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 ++G +LLP + Y S+ +E+ N G Y C A N G L Sbjct: 3931 TKNGIRLLPRGDG-----YRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVH 3985 Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEP-----EATG 526 + P ++P S V + P EATG Sbjct: 3986 EPP------VIQPQPSELHVILNNPILLPCEATG 4013 Score = 140 bits (353), Expect = 5e-33 Identities = 115/412 (27%), Positives = 174/412 (42%), Gaps = 24/412 (5%) Query: 81 LTIYNANIDDAGIYKCVVT---GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137 L I A + + G+Y+C+ G+ E E TV+V K++ + V Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP----TIKSSGLSERVVVKYKPVA 1845 Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 + + + +P P+I W + V + I S LQI D G Y C A Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA- 1904 Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 GE + IQ+ V+ PP+++ ++N T + V L C A G P P ++W KD + Sbjct: 1905 GETQ-QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS- 1962 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 F + + I+ +D Y C+A N AG + L+V P I+ N Sbjct: 1963 --GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 A+ + V L CEA G P PS+TW +SS L V S R+ +LT S Q Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ----VLSGGRILALT--SAQ 2074 Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSAT 435 +D G Y C A N G+ + + L V P + G V V + C+ A P T Sbjct: 2075 ISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPT 2134 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 ++W +DG L +I + + S L++ D G Y C A N G+ Sbjct: 2135 LTWLKDGHPLLKKPGLSI----SENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182 Score = 139 bits (350), Expect = 1e-32 Identities = 130/478 (27%), Positives = 197/478 (41%), Gaps = 41/478 (8%) Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83 +V S+ +++G+ C+ +G + WF + E L P+ I D L I Sbjct: 706 VVQSELLVALGDITVMECKTSG-IPPPQVKWFKGDLE-LRPSTFLII----DPLLGLLKI 759 Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVS 143 DAG Y CV E G + + + + +F P G + + C V Sbjct: 760 QETQDLDAGDYTCVAINEAG-RATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG 818 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEIN 200 PTI W+ I + +S L I + +D+GTY CE A + Sbjct: 819 YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICE----AENQFG 874 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDA-EGFPEPTMSWTKDGEQIEQE 257 + V V + I + AN+ GQ +TL C G P P W K+ + Q Sbjct: 875 KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 YI L I++V D EY C+A N AG + T + V P I + + Sbjct: 935 P----YITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 + VTL C+ASG+P PS+ W IS+ S SL + S Sbjct: 991 STIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF-------SAGADGSLYVVSPGG 1043 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---------PVAVYTWEGNQVNITCEV 428 ++GEY+CTA+NT G + + L V P++ G PV + G +V + CEV Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103 Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 + P I+W ++ QL+ S +S + PS S +++T +D G Y C A N G Sbjct: 1104 KSLPPPIITWAKETQLI--SPFSPRHTF-LPSGS-MKITETRTSDSGMYLCVATNIAG 1157 Score = 139 bits (349), Expect = 1e-32 Identities = 119/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I+W+ +G+ + + Q + + D L I A + D+ Y C V G+ +E + + Sbjct: 1579 ITWYK-DGQPIMSSSQALYI----DKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSFH 1632 Query: 112 VKIFQKLMFK-NAPTP--QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168 V ++ M + N TP ++ + C + P + W G V ++R I Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-IE 1691 Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228 L+I ++ D G Y C +A GE K +V V VPP I+ + Sbjct: 1692 AGGKKLEIMSAQEIDRGQYICVATSVA-GEKEIK-YEVDVLVPPAIEGGDETSYFIVMVN 1749 Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288 + L C G P PT+ W KDG+ I+ E D K + + +L I + ++ Y C+ Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLID-ERDGFKILL--NGRKLVIAQAQVSNTGLYRCM 1806 Query: 289 AENKAGEQDATIHLKVFAKPKI-TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347 A N AG+ + V P I + ++ + + V L C A+G P PSITW + Sbjct: 1807 AANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQP 1866 Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK 407 ++ T G++ ++S RV L + DAG Y C A+N G+ Q + L V P Sbjct: 1867 VN----TAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920 Query: 408 LQGPVAVY---TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464 L+ + N V + C+ P I+W++D +LL S +++ N + Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS--TSMTFLN--RGQII 1976 Query: 465 EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 ++ +D G Y C A+N G L + L PS Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013 Score = 138 bits (348), Expect = 2e-32 Identities = 115/435 (26%), Positives = 184/435 (42%), Gaps = 30/435 (6%) Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-VNVKIFQKLMFKNAPTPQEFREGEDAV 136 S ++ I D+G+Y CV T G+ ++A +NV + K+ + P + + G+ Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI--QRGPKHLKVQVGQRVD 1189 Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 I C+ + P I W KG +L + + L I +D G Y C +A Sbjct: 1190 IPCNAQGTPLPVITWS-KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAG 1248 Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATAN---LGQSVTLVCDAEGFPEPTMSWTKDGEQ 253 + +I + V PPT++ + N T Q + C A+G P+PT+ W +G + Sbjct: 1249 TDET--EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRE 1306 Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313 + E + +D + L I V D EYIC+A N+AG + +LKV P I Sbjct: 1307 LTGREPGISIL--EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDK 1364 Query: 314 ENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI--SSEEKTLDGHMVVRSHARVSS 369 E T + L + L CE G P P I W + SS +T++ +++ Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPE 1424 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITC 426 DAG Y C A N G + ++V P + G P V V + C Sbjct: 1425 ---------DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALEC 1475 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 +V P I WF+DG+ L + N+++ + +L+ ND G Y CT N G Sbjct: 1476 QVKGTPFPDIHWFKDGKPLFLGD-PNVELLDRGQVLHLKNA--RRNDKGRYQCTVSNAAG 1532 Query: 487 QESLEFILVQADTPS 501 +++ + L PS Sbjct: 1533 KQAKDIKLTIYIPPS 1547 Score = 135 bits (340), Expect = 2e-31 Identities = 117/480 (24%), Positives = 195/480 (40%), Gaps = 28/480 (5%) Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71 F L V + P I + +S C +A I+W +G L N R S+ Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITW-RKDGAVLAGNHARYSI 3762 Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE 131 + N L I +A++ D G Y C+ T G++ +++++ PT Sbjct: 3763 LEN----GFLHIQSAHVTDTGRYLCMATNAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIV 3817 Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCE 190 + C+ P+I W+ G + + ++ + +LS+ L I D TY C Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877 Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 + + + + + V VPP+I T + +T C A G P P++ WTK+ Sbjct: 3878 --VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSIHWTKN 3933 Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310 G ++ D + + S + I N Y C+A N AG + L V P I Sbjct: 3934 GIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVI 3990 Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370 ++ + L + L CEA+G P P ITW+ N+++ + H V+ S L Sbjct: 3991 QPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGR---NHAVLPS----GGL 4043 Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQ-VNITCEVF 429 + DAG Y+C A N G + L VQ P + + Y ++ + ++CE Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEAD 4103 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 P I+W +DG+ + S + S+ L++ D G+Y C A N G S Sbjct: 4104 GLPPPDITWHKDGRAIVESIRQRVL-----SSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158 Score = 128 bits (322), Expect = 2e-29 Identities = 120/513 (23%), Positives = 200/513 (38%), Gaps = 29/513 (5%) Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGED 134 + + I A + D +Y CV + G +++ N+++F N+ +E +G Sbjct: 3394 AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH-YNLQVFAPPNMDNSMGTEEITVLKGSS 3452 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRI 193 + C + P++ W G+ + L D V ++ LQ+ + D G Y C Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGL--DAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510 Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253 A GE++ K + V PP I + + + + L C A G P P M+W KDG Sbjct: 3511 EA-GEVS-KHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP 3568 Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313 + Q + + L I D Y C+A + AG+ D ++V P I Sbjct: 3569 LPQTDQVQTL---GGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT 3625 Query: 314 ENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371 + + + QVTL C++ P P ITW + + + + VR + L Sbjct: 3626 DEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR-------VRILSGGRYLQ 3678 Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA 430 + + D Y C ASN G+ ++ L V P ++ GP ++ + C Sbjct: 3679 INNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEG 3738 Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490 P+ I+W +DG +L + N++ Y+ +L + D G Y C A N G + Sbjct: 3739 VPTPRITWRKDGAVL-AGNHAR---YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRR 3794 Query: 491 EFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550 I +Q P PSI P + T V A I K WR G + + Sbjct: 3795 R-IDLQVHVP--PSI-APGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ 3850 Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583 ++ G + I+ + T NG G Sbjct: 3851 NSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883 Score = 124 bits (312), Expect = 3e-28 Identities = 115/473 (24%), Positives = 186/473 (39%), Gaps = 32/473 (6%) Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136 S +L I + D G Y CV + G+ ++ T +V + ++ EG Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIEGIPVT 999 Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 + C + P++IW KG ++I +F ++ L + + G Y C A Sbjct: 1000 LPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA- 1057 Query: 197 GEINFKDIQVIVNVPPTIQARQN------IVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 G K +Q+ V V P + Q V + G+ VTL C+ + P P ++W K+ Sbjct: 1058 GYAKRK-VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116 Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310 + I ++ S + I + +D Y+C+A N AG + L V PKI Sbjct: 1117 TQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173 Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370 +++ ++V + C A G P+P ITW + +DG V + +L Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVITW-----SKGGSTMLVDGEHHVSNPD--GTL 1226 Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNI 424 ++ +DAG Y C A+N G D + L VQ P ++ Y ++ Sbjct: 1227 SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF 1286 Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484 C P TI W +G+ L + I I + L + + D G Y C AVN Sbjct: 1287 PCPAKGTPKPTIKWLHNGREL-TGREPGISILE--DGTLLVIASVTPYDNGEYICVAVNE 1343 Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYS---STAQVQFDEPEATGGVPILKYK 534 G ++ L P +QV S + F E E T I+ YK Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396 Score = 121 bits (303), Expect = 3e-27 Identities = 116/442 (26%), Positives = 178/442 (40%), Gaps = 40/442 (9%) Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110 DI+W + +QR+ SS +L I DAG Y C+ GS S +T Sbjct: 4109 DITWHKDGRAIVESIRQRVL------SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST- 4161 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDV--RFI 167 + + ++ E A++ C V +P P I WK +D +L ++ ++ Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWK---KDNVLLANLLGKYT 4217 Query: 168 VLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL 227 L + + D G Y C A GE + + + V+V PT + + N Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVAN-NAAGE-DTHTVSLTVHVLPTFTELPG--DVSLNK 4273 Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G+ + L C A G P P ++WT + I D + S+L I++V K D Y+C Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS-----VNGHSELVIERVSKEDSGTYVC 4328 Query: 288 IAENKAGEQDATIHLKVFAKP--KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345 AEN G A + V P K Y N L L CE GDP P+I W Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIE-PLGGNAILNCEVKGDPTPTIQWNRKG 4387 Query: 346 RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405 +I + +R SL + DAG+Y C A+N G +SM L +Q Sbjct: 4388 VDIEISHR-------IRQLGN-GSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP 4439 Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464 P + PV G ++ + C+ P TI+W R G + + N+ N+ L Sbjct: 4440 PIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS-----L 4494 Query: 465 EVTPDSENDFGNYNCTAVNRIG 486 + + D + C A N +G Sbjct: 4495 YIADAQKEDTSEFECVARNLMG 4516 Score = 120 bits (302), Expect = 4e-27 Identities = 114/466 (24%), Positives = 184/466 (39%), Gaps = 27/466 (5%) Query: 25 VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIY 84 VP+ ++ GE C + A D +++W + + RI + N +L + Sbjct: 525 VPNNVTVTPGERAVLTCLIIS-AVDYNLTWQRNDRDVRLAEPARIRTLAN----LSLELK 579 Query: 85 NANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144 + +DAG Y C+V+ E GS S A+V + + + P Q F G + I+C Sbjct: 580 SVKFNDAGEYHCMVSSEGGS-SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGY 638 Query: 145 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204 P I W D+ + R+ + S+ L I+ D G Y C A + + Sbjct: 639 PKPKIAWTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696 Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264 + I P + + ++ A LG + C G P P + W K ++ I Sbjct: 697 RYI-EAPKLMVVQSELLVA---LGDITVMECKTSGIPPPQVKWFKGDLELRPSTF---LI 749 Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324 L I++ D +Y C+A N+AG I L V + P +ME+ Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSN 809 Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 VTL C G P P+I WR N+ + + S R +L + ++ +D G YI Sbjct: 810 VTLPCYVQGYPEPTIKWR-RLDNMPIFSRPFSVSSI--SQLRTGALFILNLWASDKGTYI 866 Query: 385 CTASNTIG--QDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA-YPSATISWFR 440 C A N G Q ++ + AP + P EG Q+ + C + A P W + Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK 926 Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 + +L + Y ++ S L + D G Y C A N G Sbjct: 927 NSAMLLQNPYITVR-----SDGSLHIERVQLQDGGEYTCVASNVAG 967 Score = 111 bits (277), Expect = 3e-24 Identities = 100/372 (26%), Positives = 159/372 (42%), Gaps = 35/372 (9%) Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 I C V S LP T+ + G V L D ++ L I + +DEG Y C + + Sbjct: 449 IPCSVDSLLPFTLSFVRNG--VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIA-VSSA 505 Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 G + + PP IQ N+ T G+ L C + ++W ++ + Sbjct: 506 GTGRAQTFFDVSEPPPVIQVPNNV---TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 E ++ S L +K V ND EY C+ ++ G A++ L V PK+T + Sbjct: 563 AEPARIRTLANLS--LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKN 620 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-RVSS---LTL 372 + +V++ C A+G P P I W T++ +V SH R++S L + Sbjct: 621 QSFTGGSEVSIMCSATGYPKPKIAW------------TVNDMFIVGSHRYRMTSDGTLFI 668 Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVF 429 K+ DAG Y C ASN+ G D Q+ L APKL Q + V G+ + C+ Sbjct: 669 KNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVAL--GDITVMECKTS 726 Query: 430 AYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 P + WF+ D +L PS+ + P L++ + D G+Y C A+N G+ Sbjct: 727 GIPPPQVKWFKGDLELRPST-----FLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 781 Query: 489 SLEFILVQADTP 500 + + L P Sbjct: 782 TGKITLDVGSPP 793 >gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform ROBO2a [Homo sapiens] Length = 1394 Score = 162 bits (410), Expect = 1e-39 Identities = 186/734 (25%), Positives = 287/734 (39%), Gaps = 89/734 (12%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ +GE++ P R+ + Sbjct: 53 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 110 Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139 + + D G Y CV G ++++ + F+ PT GE A++ C Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170 Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198 P PTI WK K + I K+ R I + L I +K+D G Y C G + GE Sbjct: 171 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 227 Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 + ++ V PT R +N ++V C +G P+PT+ W KD + + Sbjct: 228 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 285 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+ Sbjct: 286 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 340 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373 + VT CE G+P P++ W+ + L + + ++R S LT+ Sbjct: 341 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 395 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426 +IQ +DAG YIC A G LEV LQGP + C Sbjct: 396 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 455 Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 + P ISW ++G P + + I+ T L + +D G Y C A + Sbjct: 456 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 510 Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532 G+ S +L +D P PS QV + + +P G +P Sbjct: 511 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 570 Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+ Sbjct: 571 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 627 Query: 593 FKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGGSPIRH 634 PV+ + +P +G Q+ ++ + V L D I+ Sbjct: 628 ----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQG 683 Query: 635 YLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAA 686 Y V YR S S W+ + ++P+ V++ +L YE+ V QG + Sbjct: 684 YRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQGMDSES 742 Query: 687 HFVFRTSAQPTAIP 700 V T P+A P Sbjct: 743 KTVRTTEEAPSAPP 756 Score = 53.9 bits (128), Expect = 6e-07 Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ S++ LEV Q P V G Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 166 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TI W +D ++ I I L ++ ++D G Y C Sbjct: 167 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 221 Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525 N +G+ + E + + T I+QV E QVQ D P+ T Sbjct: 222 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 271 >gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform ROBO2b [Homo sapiens] Length = 1378 Score = 162 bits (410), Expect = 1e-39 Identities = 186/734 (25%), Positives = 287/734 (39%), Gaps = 89/734 (12%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ +GE++ P R+ + Sbjct: 37 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 94 Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139 + + D G Y CV G ++++ + F+ PT GE A++ C Sbjct: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154 Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198 P PTI WK K + I K+ R I + L I +K+D G Y C G + GE Sbjct: 155 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 211 Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 + ++ V PT R +N ++V C +G P+PT+ W KD + + Sbjct: 212 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+ Sbjct: 270 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373 + VT CE G+P P++ W+ + L + + ++R S LT+ Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 379 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426 +IQ +DAG YIC A G LEV LQGP + C Sbjct: 380 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 439 Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 + P ISW ++G P + + I+ T L + +D G Y C A + Sbjct: 440 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 494 Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532 G+ S +L +D P PS QV + + +P G +P Sbjct: 495 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 554 Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+ Sbjct: 555 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 611 Query: 593 FKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGGSPIRH 634 PV+ + +P +G Q+ ++ + V L D I+ Sbjct: 612 ----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQG 667 Query: 635 YLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAA 686 Y V YR S S W+ + ++P+ V++ +L YE+ V QG + Sbjct: 668 YRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQGMDSES 726 Query: 687 HFVFRTSAQPTAIP 700 V T P+A P Sbjct: 727 KTVRTTEEAPSAPP 740 Score = 53.9 bits (128), Expect = 6e-07 Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ S++ LEV Q P V G Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TI W +D ++ I I L ++ ++D G Y C Sbjct: 151 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 205 Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525 N +G+ + E + + T I+QV E QVQ D P+ T Sbjct: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 255 >gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3783 Score = 155 bits (391), Expect = 2e-37 Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%) Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137 S L I A AG Y C G + V + + + K P+ E+ ++ Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2685 Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C+ PTI W+ +G +V + VL L+I D G Y C + A Sbjct: 2686 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 + +++V VPP I+ + + + G L C A G PEP ++W KDG+ + Sbjct: 2744 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2799 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 E K+ S +L +K ++ D Y C AEN G +HL + P T + Sbjct: 2800 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2856 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 ++ L +++ L C A G P P I W + R ++ DG S+L ++ Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2907 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435 D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P Sbjct: 2908 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 2967 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 I W +DG L S+ + ++ N L + +D G Y C A N +G ILV Sbjct: 2968 IHWIKDGLPLRGSHLRH-QLQN----GSLTIRRTERDDAGRYQCLAENEMGVAKKVVILV 3022 Query: 496 QADTPSSPSIDQVEPYSSTAQ 516 P + QVEP T + Sbjct: 3023 LQSAP----VFQVEPQDMTVR 3039 Score = 148 bits (374), Expect = 2e-35 Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 + VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D Sbjct: 1762 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1815 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149 G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+ Sbjct: 1816 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209 W K R + V +V LQ+ ++ GTY C + E KD V V Sbjct: 1875 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 1931 Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269 V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991 Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325 S L +K + +D Y C+A N AGE DA +H + V P I + + + E V Sbjct: 1992 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049 Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 T+ C G P ++W + ++TL H +L + +Q DAG + C Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2102 Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441 A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D Sbjct: 2103 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 G+ L S + + PS L++ D G Y+C AV+ G+ F L + P Sbjct: 2162 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2212 Score = 147 bits (371), Expect = 4e-35 Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108 I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED + Sbjct: 1389 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1443 Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152 + V +FQK+ F+ +E R E A + CD + PP + W Sbjct: 1444 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1503 Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210 + + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V Sbjct: 1504 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1558 Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 PP I + + T N +V+L C A G P PT+SW ++G + +D Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1615 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327 L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L Sbjct: 1616 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1675 Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387 C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A Sbjct: 1676 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1728 Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442 N G+D + + L V P +GP AV G++ ++CE A P T++W++DG Sbjct: 1729 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1788 Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497 Q L + + LE+ +D G Y+C N G+ F L VQ Sbjct: 1789 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1844 Query: 498 DTPSSPSIDQV 508 + P + ++ QV Sbjct: 1845 ENPKTETVSQV 1855 Score = 136 bits (342), Expect = 9e-32 Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138 L + A + G Y C + G+ S+ + V + ++ + PT + A + Sbjct: 938 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197 C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R Sbjct: 998 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056 Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E + Sbjct: 1057 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 ED Y+ + L + + + D Y C+A N+AGE ++V P I + + Sbjct: 1114 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1170 Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 +++ + T L C +G P P +TW R ++ D H H + L+ Sbjct: 1171 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 1221 Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426 +Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C Sbjct: 1222 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 1281 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G Sbjct: 1282 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 1337 Query: 487 QESLEFILVQADTPSSPSIDQVEP 510 E+++ V+ P PSI + +P Sbjct: 1338 -EAVKNYHVEVLIP--PSISKDDP 1358 Score = 131 bits (329), Expect = 3e-30 Identities = 121/473 (25%), Positives = 187/473 (39%), Gaps = 28/473 (5%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I ++ D GIY C T G ES+ V +K+ + P + E + C Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199 PP + W KG + + + L+I + +D G+YRC + E+ Sbjct: 627 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685 Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 + + VNVPP I ++ + V L C+A G P PT+ W KDG + Sbjct: 686 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 741 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 +F LT+ +D Y C+A + GE + L+V P I E ++ Sbjct: 742 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 800 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E V L C++ P P ++W + + L+ V A + L + D Sbjct: 801 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 853 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 AG Y C A N G + L V AP L+ + EG+ ++CE P IS Sbjct: 854 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKIS 913 Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 W +DGQ LP + YL ++ G Y C N +G S + +Q Sbjct: 914 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 968 Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544 + P I EP + + VQ E ATG P + ++ + + VG E+ Sbjct: 969 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 1021 Score = 131 bits (329), Expect = 3e-30 Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%) Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147 D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P Sbjct: 1135 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1193 Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207 + W GR + + D I LQ+ + G Y C A GE K Q+ Sbjct: 1194 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1250 Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V + PTI + V T N ++L+C+A FP P ++W KDG E + + Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1307 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315 + L I K D +Y C+ N+ GE H++V P I+ + Sbjct: 1308 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVK 1365 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 + ++ +TL CE+ P P+I W + ++ + + V R+ L ++ Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1418 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415 Q +D+G Y+C A+N G+D Q + +Q P Q G V Y Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478 Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474 E N + C+ A P ++W+R+ Q L + + ++ L++ + Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1534 Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500 G Y+C A N +G++ L + L+ P Sbjct: 1535 GRYSCKASNEVGEDWLHYELLVLTPP 1560 Score = 130 bits (327), Expect = 5e-30 Identities = 114/431 (26%), Positives = 172/431 (39%), Gaps = 44/431 (10%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I +A+ +DAG Y C+ GS T + + + +N EG A + C Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195 S P I W G+ V + +F + + L ++ ++ D GTY C GR Sbjct: 2779 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2837 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 R + + V +P R LG + L C A G P P + WT + + Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2888 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + ++ D S L V + D Y+C AEN+ G A + V P + Sbjct: 2889 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 2943 Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370 +E + + L C GDP+P I W DG + SH R SL Sbjct: 2944 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 2991 Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429 T++ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+ Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3051 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G + Sbjct: 3052 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3106 Query: 490 LEFILVQADTP 500 LV P Sbjct: 3107 ARAFLVVRGEP 3117 Score = 129 bits (324), Expect = 1e-29 Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GE +C V G + +SW +G L +Q+ + S TL I + DAGI Sbjct: 2046 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2099 Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146 + CV G ++ T+ V++ L P EF+ D V+V + LP Sbjct: 2100 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2151 Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204 P + W G ++ + + LQ+ + D GTY C + GE + Sbjct: 2152 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2204 Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264 Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ + Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2262 Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322 + + D Y C+AE+ AG + + ++V A P I + Sbjct: 2263 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2314 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 Q+ L C +P P ITW I +E D H R L L+++ D+G+ Sbjct: 2315 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2367 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427 Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 L P S I P S L + P D G+Y C A N G + Sbjct: 2428 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470 Score = 120 bits (300), Expect = 7e-27 Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P++ ++ G LC G + +I+W +G+ LT + ++S +T + Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2267 Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144 + DAG+Y C+ G+ E V V+ ++ P V+ C V + Sbjct: 2268 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326 Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202 P I W G ++L++D +LQ++ + D G Y C R A + F+ Sbjct: 2327 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384 Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ + Sbjct: 2385 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2439 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322 + L I+ V D Y+C+A N AG L+V P I + + Sbjct: 2440 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 L CEASG P P + W + + + + ++ S+A L L + D+ + Sbjct: 2497 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2551 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441 + C SN +G+ + + V P + +T V +TC P+ T+SW + Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500 G L + Y + LE+ G Y C+A N G F+ VQA Sbjct: 2612 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2667 Query: 501 SSP 503 P Sbjct: 2668 VKP 2670 Score = 119 bits (297), Expect = 2e-26 Identities = 87/296 (29%), Positives = 124/296 (41%), Gaps = 31/296 (10%) Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS--- 266 VPP+I+ N + GQS+TL CDA GFP P + W KD + + Y + Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74 Query: 267 ---------DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV-ENQ 316 D+ L ++ + D Y C AEN+AG HL V P + Q Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134 Query: 317 TAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG--HMVVRSHARVSSLTLK 373 + L V L C SG P P + W + L G H+ V+ +V +T Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEW------TKDRQPVLPGGPHLQVQEDGQVLRITGS 188 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFA 430 + D G Y C A + GQ ++ L V P + G V E + V + CE Sbjct: 189 HV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246 Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 P+ I+WF+DG LLP+S K+ T L++ +D G Y C A N +G Sbjct: 247 VPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298 Score = 114 bits (284), Expect = 5e-25 Identities = 105/452 (23%), Positives = 170/452 (37%), Gaps = 43/452 (9%) Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110 D+ W G +L D +L D+G+Y C + G+ ++ Sbjct: 71 DLGWGQVGGHRLL------------DEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDF 117 Query: 111 NVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168 ++ + A QE G D + C P + W + V+ + Sbjct: 118 HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ 177 Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228 L+I G DEG Y+C A + +D Q+ V+ PPTI Sbjct: 178 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMED 235 Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288 V L+C+A G P P ++W KDG + K +++ QL + + +D Y C Sbjct: 236 HLVQLLCEARGVPTPNITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292 Query: 289 AENKAGEQDATIHLKVFAKPKI------TYVENQTAMELEEQVTLTCEASGDPIPSITWR 342 A N G + L V+ P I YV A V L C A G P P+++W Sbjct: 293 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWH 349 Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402 ++ ++ R S L L+S +G Y C AS+ G+ +EV Sbjct: 350 HEGLPVAESNES-------RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 402 Query: 403 QYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459 Q P+L +G V T G + + C+ P TI W ++G+ P+ + +++ Sbjct: 403 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--AS 458 Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491 + L + + G + C A N G E Sbjct: 459 QGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490 Score = 110 bits (274), Expect = 7e-24 Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%) Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86 GE++V E LC+ G +I+WF L P ++ L + A Sbjct: 228 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 281 Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143 DAG+Y C + G+ +AT + ++ + A P + G + C Sbjct: 282 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 PT+ W H+G V + R + + L++ + G Y C A GE + Sbjct: 341 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 397 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ + Sbjct: 398 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 455 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320 + + L I V+ + + C A N+AG A + + V + P + V Q Sbjct: 456 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 514 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374 E + A+ DP W + E G + + +++ L ++ Sbjct: 515 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 572 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433 + D G Y C A+N G+ + + L+V P ++ GPV E V + C P Sbjct: 573 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 632 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 +SWF+ Q P S++ + + + L + +D G+Y C A N G L + Sbjct: 633 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687 Score = 106 bits (264), Expect = 1e-22 Identities = 95/382 (24%), Positives = 162/382 (42%), Gaps = 41/382 (10%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG Sbjct: 2770 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2823 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C G + V++ I +F P + R G+ + C S P I W Sbjct: 2824 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882 Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208 R V + ++D + LQ + + D GTY C E R+ ++F V V Sbjct: 2883 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 2932 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 P +Q + +G S+ L C G P P + W KDG + + Sbjct: 2933 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 2987 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 + LTI++ +++D Y C+AEN+ G + L + + P + + V L Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047 Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3096 Query: 386 TASNTIGQDSQSMYLEVQYAPK 407 A N +G + +L V+ P+ Sbjct: 3097 VAHNLLGSATARAFLVVRGEPQ 3118 Score = 61.6 bits (148), Expect = 3e-09 Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 22/187 (11%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEK-----------TLDGHMVVRSHARVSSLT 371 + +TL C+A+G P+P I W + + + GH ++ SL Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLH 90 Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITCEV 428 IQ D+G Y C A N G + +L V P + G A V G V + C Sbjct: 91 FPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWT 150 Query: 429 FAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 P+ + W +D Q +LP + ++ L +T D G Y C A + GQ Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206 Query: 488 ESLEFIL 494 ++ +F L Sbjct: 207 QARDFQL 213 >gi|19743806 roundabout 1 isoform b [Homo sapiens] Length = 1612 Score = 154 bits (390), Expect = 3e-37 Identities = 193/733 (26%), Positives = 279/733 (38%), Gaps = 85/733 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 +Y DD + L I+KV D Y C+AEN G+ +A+ L V P Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372 + L VT CEA+G+P P+I WR + L + +S +R S LT+ Sbjct: 322 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376 Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425 ++Q +D G YIC N G YLEV P + QGPV ++ Sbjct: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436 Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 492 Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530 G+ E EF + VQ PS+PS +V S +P G Sbjct: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552 Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590 Y E S W E I GLKP Y + A N G+ + S Sbjct: 553 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609 Query: 591 SE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPIRHY 635 S+ KTQ P +++ ++G +SI+V+ D I+ Y Sbjct: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGY 668 Query: 636 LVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAAH 687 + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 669 KILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIK 727 Query: 688 FVFRTSAQPTAIP 700 F P+A P Sbjct: 728 FAKTLEEAPSAPP 740 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 204 TNMVGERESE 213 >gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] Length = 3874 Score = 154 bits (390), Expect = 3e-37 Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%) Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137 S L I A AG Y C G + V + + + K P+ E+ ++ Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776 Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C+ PTI W+ +G +V + VL L+I D G Y C + A Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 + +++V VPP I+ + + + G L C A G PEP ++W KDG+ + Sbjct: 2835 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2890 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 E K+ S +L +K ++ D Y C AEN G +HL + P T + Sbjct: 2891 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2947 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 ++ L +++ L C A G P P I W + R ++ DG S+L ++ Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2998 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435 D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P Sbjct: 2999 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 3058 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 I W +DG L S+ + ++ N L + +D G Y C A N +G ILV Sbjct: 3059 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 3113 Query: 496 QADTPSSPSIDQVEPYSSTAQ 516 P + QVEP T + Sbjct: 3114 LQSAP----VFQVEPQDMTVR 3130 Score = 148 bits (374), Expect = 2e-35 Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 + VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D Sbjct: 1853 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1906 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149 G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+ Sbjct: 1907 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209 W K R + V +V LQ+ ++ GTY C + E KD V V Sbjct: 1966 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 2022 Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269 V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082 Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325 S L +K + +D Y C+A N AGE DA +H + V P I + + + E V Sbjct: 2083 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140 Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 T+ C G P ++W + ++TL H +L + +Q DAG + C Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2193 Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441 A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D Sbjct: 2194 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 G+ L S + + PS L++ D G Y+C AV+ G+ F L + P Sbjct: 2253 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2303 Score = 147 bits (371), Expect = 4e-35 Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108 I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED + Sbjct: 1480 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1534 Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152 + V +FQK+ F+ +E R E A + CD + PP + W Sbjct: 1535 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1594 Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210 + + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V Sbjct: 1595 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1649 Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 PP I + + T N +V+L C A G P PT+SW ++G + +D Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1706 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327 L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L Sbjct: 1707 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1766 Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387 C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A Sbjct: 1767 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1819 Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442 N G+D + + L V P +GP AV G++ ++CE A P T++W++DG Sbjct: 1820 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1879 Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497 Q L + + LE+ +D G Y+C N G+ F L VQ Sbjct: 1880 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1935 Query: 498 DTPSSPSIDQV 508 + P + ++ QV Sbjct: 1936 ENPKTETVSQV 1946 Score = 136 bits (342), Expect = 9e-32 Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138 L + A + G Y C + G+ S+ + V + ++ + PT + A + Sbjct: 1029 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197 C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R Sbjct: 1089 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147 Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E + Sbjct: 1148 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1204 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 ED Y+ + L + + + D Y C+A N+AGE ++V P I + + Sbjct: 1205 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1261 Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 +++ + T L C +G P P +TW R ++ D H H + L+ Sbjct: 1262 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 1312 Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426 +Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C Sbjct: 1313 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 1372 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G Sbjct: 1373 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 1428 Query: 487 QESLEFILVQADTPSSPSIDQVEP 510 E+++ V+ P PSI + +P Sbjct: 1429 -EAVKNYHVEVLIP--PSISKDDP 1449 Score = 132 bits (331), Expect = 2e-30 Identities = 121/473 (25%), Positives = 189/473 (39%), Gaps = 28/473 (5%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I ++ D GIY C T G ES+ V +K+ + P + E + C Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199 PP + W KG + + + L+I + +D G+YRC + E+ Sbjct: 718 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776 Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 + + VNVPP I ++ + V L C+A G P PT+ W KDG + Sbjct: 777 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 832 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 +F LT+ +D Y C+A + GE + L+V P I E ++ Sbjct: 833 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 891 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E V L C++ P P ++W + + L+ V A + L + D Sbjct: 892 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 944 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 AG Y C A N G+ + L V AP L+ + EG+ +++CE P IS Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 1004 Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 W +DGQ LP + YL ++ G Y C N +G S + +Q Sbjct: 1005 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 1059 Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544 + P I EP + + VQ E ATG P + ++ + + VG E+ Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 1112 Score = 131 bits (329), Expect = 3e-30 Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%) Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147 D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P Sbjct: 1226 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1284 Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207 + W GR + + D I LQ+ + G Y C A GE K Q+ Sbjct: 1285 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1341 Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V + PTI + V T N ++L+C+A FP P ++W KDG E + + Sbjct: 1342 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1398 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315 + L I K D +Y C+ N+ GE H++V P I+ + Sbjct: 1399 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 1456 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 + ++ +TL CE+ P P+I W + ++ + + V R+ L ++ Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1509 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415 Q +D+G Y+C A+N G+D Q + +Q P Q G V Y Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1569 Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474 E N + C+ A P ++W+R+ Q L + + ++ L++ + Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1625 Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500 G Y+C A N +G++ L + L+ P Sbjct: 1626 GRYSCKASNEVGEDWLHYELLVLTPP 1651 Score = 129 bits (324), Expect = 1e-29 Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GE +C V G + +SW +G L +Q+ + S TL I + DAGI Sbjct: 2137 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2190 Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146 + CV G ++ T+ V++ L P EF+ D V+V + LP Sbjct: 2191 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2242 Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204 P + W G ++ + + LQ+ + D GTY C + GE + Sbjct: 2243 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2295 Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264 Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ + Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2353 Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322 + + D Y C+AE+ AG + + ++V A P I + Sbjct: 2354 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2405 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 Q+ L C +P P ITW I +E D H R L L+++ D+G+ Sbjct: 2406 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2458 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D Sbjct: 2459 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518 Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 L P S I P S L + P D G+Y C A N G + Sbjct: 2519 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561 Score = 129 bits (324), Expect = 1e-29 Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I +A+ +DAG Y C+ GS T + + + +N EG A + C Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195 S P I W G+ V + +F + + L ++ ++ D GTY C GR Sbjct: 2870 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2928 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 R + + V +P R LG + L C A G P P + WT + + Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2979 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + ++ D S L V + D Y+C AEN+ G A + V P + Sbjct: 2980 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 3034 Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370 +E + + L C GDP+P I W DG + SH R SL Sbjct: 3035 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 3082 Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429 T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+ Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3142 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G + Sbjct: 3143 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3197 Query: 490 LEFILVQADTP 500 LV P Sbjct: 3198 ARAFLVVRGEP 3208 Score = 120 bits (300), Expect = 7e-27 Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P++ ++ G LC G + +I+W +G+ LT + ++S +T + Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2358 Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144 + DAG+Y C+ G+ E V V+ ++ P V+ C V + Sbjct: 2359 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417 Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202 P I W G ++L++D +LQ++ + D G Y C R A + F+ Sbjct: 2418 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475 Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ + Sbjct: 2476 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2530 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322 + L I+ V D Y+C+A N AG L+V P I + + Sbjct: 2531 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 L CEASG P P + W + + + + ++ S+A L L + D+ + Sbjct: 2588 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2642 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441 + C SN +G+ + + V P + +T V +TC P+ T+SW + Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500 G L + Y + LE+ G Y C+A N G F+ VQA Sbjct: 2703 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2758 Query: 501 SSP 503 P Sbjct: 2759 VKP 2761 Score = 112 bits (280), Expect = 1e-24 Identities = 121/485 (24%), Positives = 184/485 (37%), Gaps = 52/485 (10%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C G K + ++W + Q ++V+ +L + + + D+G Y+C T Sbjct: 24 CGTHGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGDYECQATN 78 Query: 101 EDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI 159 E GS S A + V + + G+ + CD P I+W + V Sbjct: 79 EVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138 Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTY----RCE-GRILARGEINFKDIQVIVN----- 209 + + Q+ G + DEG R + GR RG Q Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198 Query: 210 ---------------VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254 PP++ G V L C G P P + WTKD + + Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV 258 Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314 +D L I DE Y C+A + AG+Q L+V A P I + Sbjct: 259 --LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGS 315 Query: 315 NQT---AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371 N+T A+ + V L CEA G P P+ITW + + K +V R L Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQ 368 Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCE 427 L Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 428 Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 +PS T+SW +G + SN S ++ S L + E G Y+C A + G+ Sbjct: 429 ARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGE 484 Query: 488 ESLEF 492 L++ Sbjct: 485 AVLQY 489 Score = 110 bits (274), Expect = 7e-24 Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%) Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86 GE++V E LC+ G +I+WF L P ++ L + A Sbjct: 319 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 372 Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143 DAG+Y C + G+ +AT + ++ + A P + G + C Sbjct: 373 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 PT+ W H+G V + R + + L++ + G Y C A GE + Sbjct: 432 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 488 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ + Sbjct: 489 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 546 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320 + + L I V+ + + C A N+AG A + + V + P + V Q Sbjct: 547 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 605 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374 E + A+ DP W + E G + + +++ L ++ Sbjct: 606 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 663 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433 + D G Y C A+N G+ + + L+V P ++ GPV E V + C P Sbjct: 664 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 723 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 +SWF+ Q P S++ + + + L + +D G+Y C A N G L + Sbjct: 724 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778 Score = 108 bits (271), Expect = 2e-23 Identities = 91/369 (24%), Positives = 144/369 (39%), Gaps = 28/369 (7%) Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG 191 G D + C P + W + V+ + L+I G DEG Y+C Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291 Query: 192 RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG 251 A + +D Q+ V+ PPTI V L+C+A G P P ++W KDG Sbjct: 292 FSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349 Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI- 310 + K +++ QL + + +D Y C A N G + L V+ P I Sbjct: 350 ALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 406 Query: 311 -----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365 YV A V L C A G P P+++W ++ ++ R Sbjct: 407 GAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWHHEGLPVAESNES-------RLET 456 Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQV 422 S L L+S +G Y C AS+ G+ +EVQ P+L +G V T G + Sbjct: 457 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 516 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 + C+ P TI W ++G+ P+ + +++ + L + + G + C A Sbjct: 517 ELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--ASQGTTLHIDHVELDHSGLFACQAT 572 Query: 483 NRIGQESLE 491 N G E Sbjct: 573 NEAGTAGAE 581 Score = 105 bits (261), Expect = 2e-22 Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG Sbjct: 2861 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2914 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C G + V++ I +F P + R G+ + C S P I W Sbjct: 2915 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973 Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208 R V + ++D + LQ + + D GTY C E R+ ++F V V Sbjct: 2974 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 3023 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 P +Q + +G S+ L C G P P + W KDG + + Sbjct: 3024 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 3078 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 + LTI + +++D Y C+AEN+ G + L + + P + + V L Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138 Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3187 Query: 386 TASNTIGQDSQSMYLEVQYAPK 407 A N +G + +L V+ P+ Sbjct: 3188 VAHNLLGSATARAFLVVRGEPQ 3209 Score = 102 bits (255), Expect = 1e-21 Identities = 107/441 (24%), Positives = 183/441 (41%), Gaps = 42/441 (9%) Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134 + L I +++ D G Y+CV G ++ + + V + N E Sbjct: 269 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 328 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFI-VLSNNYLQIRGIKKTDEGTYRCE-GR 192 ++C+ P I W G +L + + LQ+ + +D G Y C+ Sbjct: 329 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386 Query: 193 ILARGEINFKDIQVIVNVPPTIQ---ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249 + E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW Sbjct: 387 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 441 Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309 +G + + + D S L ++ + Y C+A + AGE ++V P+ Sbjct: 442 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 498 Query: 310 ITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 + E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++ Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 551 Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424 ++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + + Sbjct: 552 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 610 Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473 + P W +G P S + + I + Y+ P L++ D Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 668 Query: 474 FGNYNCTAVNRIGQESLEFIL 494 G Y C A N G+ E L Sbjct: 669 EGIYTCAATNLAGESKREVAL 689 Score = 35.4 bits (80), Expect = 0.22 Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 5/77 (6%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 G V + C P+ + W +D Q +LP + ++ L +T D G Y Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRY 287 Query: 478 NCTAVNRIGQESLEFIL 494 C A + GQ++ +F L Sbjct: 288 QCVAFSPAGQQARDFQL 304 >gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] Length = 5065 Score = 154 bits (390), Expect = 3e-37 Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%) Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137 S L I A AG Y C G + V + + + K P+ E+ ++ Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967 Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C+ PTI W+ +G +V + VL L+I D G Y C + A Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 + +++V VPP I+ + + + G L C A G PEP ++W KDG+ + Sbjct: 4026 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 4081 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 E K+ S +L +K ++ D Y C AEN G +HL + P T + Sbjct: 4082 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 4138 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 ++ L +++ L C A G P P I W + R ++ DG S+L ++ Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 4189 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435 D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P Sbjct: 4190 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 4249 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 I W +DG L S+ + ++ N L + +D G Y C A N +G ILV Sbjct: 4250 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 4304 Query: 496 QADTPSSPSIDQVEPYSSTAQ 516 P + QVEP T + Sbjct: 4305 LQSAP----VFQVEPQDMTVR 4321 Score = 148 bits (374), Expect = 2e-35 Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 + VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D Sbjct: 3044 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 3097 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149 G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+ Sbjct: 3098 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209 W K R + V +V LQ+ ++ GTY C + E KD V V Sbjct: 3157 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 3213 Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269 V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273 Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325 S L +K + +D Y C+A N AGE DA +H + V P I + + + E V Sbjct: 3274 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331 Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 T+ C G P ++W + ++TL H +L + +Q DAG + C Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 3384 Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441 A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D Sbjct: 3385 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 G+ L S + + PS L++ D G Y+C AV+ G+ F L + P Sbjct: 3444 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 3494 Score = 147 bits (371), Expect = 4e-35 Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108 I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED + Sbjct: 2671 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 2725 Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152 + V +FQK+ F+ +E R E A + CD + PP + W Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785 Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210 + + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V Sbjct: 2786 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 2840 Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 PP I + + T N +V+L C A G P PT+SW ++G + +D Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 2897 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327 L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L Sbjct: 2898 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 2957 Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387 C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A Sbjct: 2958 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 3010 Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442 N G+D + + L V P +GP AV G++ ++CE A P T++W++DG Sbjct: 3011 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 3070 Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497 Q L + + LE+ +D G Y+C N G+ F L VQ Sbjct: 3071 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 3126 Query: 498 DTPSSPSIDQV 508 + P + ++ QV Sbjct: 3127 ENPKTETVSQV 3137 Score = 144 bits (363), Expect = 3e-34 Identities = 132/498 (26%), Positives = 203/498 (40%), Gaps = 52/498 (10%) Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71 + LG V QV P ++ VGE+ C G+ + + +SW S +G L + SV Sbjct: 1112 YVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSW-SKDGVVLQGRGPQGSV 1169 Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQ--EF 129 + +S DAG Y+C + G ++ V +++ + + T E Sbjct: 1170 HFAAIRTS----------DAGRYRCEASNSAGVDAWE-VELRVLEPPHWGADETSGLLER 1218 Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189 GE+A + C + P + W+ L VL L + + D G Y C Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278 Query: 190 EGRILARGEINF--KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247 + A E+ + +++V VPP+I+ N + GQS+TL CDA GFP P + W Sbjct: 1279 Q----ATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334 Query: 248 TKDGEQIEQEEDDEKYIFS------------DDSSQLTIKKVDKNDEAEYICIAENKAGE 295 KD + + Y + D+ L ++ + D Y C AEN+AG Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394 Query: 296 QDATIHLKVFAKPKITYV-ENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEK 353 HL V P + Q + L V L C SG P P + W + Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW------TKDRQP 1448 Query: 354 TLDG--HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410 L G H+ V+ +V +T + D G Y C A + GQ ++ L V P + G Sbjct: 1449 VLPGGPHLQVQEDGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 1506 Query: 411 --PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468 V E + V + CE P+ I+WF+DG LLP+S K+ T L++ Sbjct: 1507 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGR 1562 Query: 469 DSENDFGNYNCTAVNRIG 486 +D G Y C A N +G Sbjct: 1563 AQSSDAGVYTCKASNAVG 1580 Score = 140 bits (354), Expect = 4e-33 Identities = 137/488 (28%), Positives = 197/488 (40%), Gaps = 49/488 (10%) Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80 QV I S S G C +G ISW + + RI V D+ T Sbjct: 609 QVSIHTSSQHFSQGVEVKVSCSASG-YPTPHISWSRES--QALQEDSRIHV----DAQGT 661 Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE------GED 134 L I +DAG Y C T E G++ E L + + P+ GE+ Sbjct: 662 LIIQGVAPEDAGNYSCQATNEVGTDQETVT-------LYYTDPPSVSAVNAVVLVAVGEE 714 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194 AV+VC+ PP +IW G ++IL + S+ L+I ++ D GTY C Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCR---- 766 Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQ 253 A E+ ++ + V Q + + T LG+S L C A G P PT++W + DG+ Sbjct: 767 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826 Query: 254 IEQEEDDEKYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV--FAKPK 309 + + S DS L + V D+A Y+C A N G+ A L V A P+ Sbjct: 827 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886 Query: 310 ITYVENQTAMELEEQVTLTCEA-SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368 I + + V+L C +G P+P W R + + S Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR--------HSIRADG 938 Query: 369 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY--TWEGNQVNITC 426 SL L AG Y C A+NT G + + L VQ P++ P A + T EG ++ C Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH-PTATHHITNEGVPASLPC 997 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 P+ TI+W ++ L S YN L + S D G Y CTA N +G Sbjct: 998 VASGVPAPTITWTKETNALTSRGPH----YNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 1053 Query: 487 QESLEFIL 494 S E L Sbjct: 1054 FSSQEMRL 1061 Score = 136 bits (342), Expect = 9e-32 Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138 L + A + G Y C + G+ S+ + V + ++ + PT + A + Sbjct: 2220 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197 C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R Sbjct: 2280 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338 Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E + Sbjct: 2339 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 ED Y+ + L + + + D Y C+A N+AGE ++V P I + + Sbjct: 2396 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 2452 Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 +++ + T L C +G P P +TW R ++ D H H + L+ Sbjct: 2453 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 2503 Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426 +Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C Sbjct: 2504 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 2563 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G Sbjct: 2564 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 2619 Query: 487 QESLEFILVQADTPSSPSIDQVEP 510 E+++ V+ P PSI + +P Sbjct: 2620 -EAVKNYHVEVLIP--PSISKDDP 2640 Score = 131 bits (330), Expect = 2e-30 Identities = 121/473 (25%), Positives = 188/473 (39%), Gaps = 28/473 (5%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I ++ D GIY C T G ES+ V +K+ + P + E + C Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199 PP + W KG + + + L+I + +D G+YRC + E+ Sbjct: 1909 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967 Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 + + VNVPP I ++ + V L C+A G P PT+ W KDG + Sbjct: 1968 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 2023 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 +F LT+ +D Y C+A + GE + L+V P I E ++ Sbjct: 2024 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 2082 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E V L C++ P P ++W + + L+ V A + L + D Sbjct: 2083 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 2135 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 AG Y C A N G + L V AP L+ + EG+ +++CE P IS Sbjct: 2136 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 2195 Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 W +DGQ LP + YL ++ G Y C N +G S + +Q Sbjct: 2196 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 2250 Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544 + P I EP + + VQ E ATG P + ++ + + VG E+ Sbjct: 2251 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 2303 Score = 131 bits (329), Expect = 3e-30 Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%) Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147 D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P Sbjct: 2417 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 2475 Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207 + W GR + + D I LQ+ + G Y C A GE K Q+ Sbjct: 2476 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 2532 Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V + PTI + V T N ++L+C+A FP P ++W KDG E + + Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 2589 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315 + L I K D +Y C+ N+ GE H++V P I+ + Sbjct: 2590 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 2647 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 + ++ +TL CE+ P P+I W + ++ + + V R+ L ++ Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 2700 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415 Q +D+G Y+C A+N G+D Q + +Q P Q G V Y Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760 Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474 E N + C+ A P ++W+R+ Q L + + ++ L++ + Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 2816 Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500 G Y+C A N +G++ L + L+ P Sbjct: 2817 GRYSCKASNEVGEDWLHYELLVLTPP 2842 Score = 130 bits (327), Expect = 5e-30 Identities = 120/473 (25%), Positives = 199/473 (42%), Gaps = 37/473 (7%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 +S GE+ C+V G+A +++W + L + R++ + + +L I D Sbjct: 528 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 581 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 G Y+CV + +G + A+V + + + + Q F +G + + C P I Sbjct: 582 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 640 Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208 W + + L++D R V + L I+G+ D G Y C+ A E+ + + + Sbjct: 641 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 694 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267 PP++ A +V +G+ LVC+A G P P + W + G E I E Sbjct: 695 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 745 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327 S +L I + D Y C A N+ G+ A I L V P++T + +EL L Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805 Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386 C A+G P P++TWR L RS S L +S+ D Y+C Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 863 Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442 A N G+ +++ + +AP V EG V++ C V A P W +DG Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923 Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 + LP + +I+ + L + + G Y+C A N G + + LV Sbjct: 924 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 971 Score = 129 bits (324), Expect = 1e-29 Identities = 124/481 (25%), Positives = 194/481 (40%), Gaps = 43/481 (8%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GE+ C G K + ++W + Q ++V+ +L + + + D+G Sbjct: 1221 GENASLPCPARGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGD 1275 Query: 94 YKCVVTGEDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152 Y+C T E GS S A + V + + G+ + CD P I+W Sbjct: 1276 YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335 Query: 153 HKGRDVILKK-------DVRFIVLSNNYLQIRG-------IKKTDEGTYRCEGRILARGE 198 + V + D+ + + + L G I++ D G Y C A G Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA-GT 1394 Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 +D ++V PP++ G V L C G P P + WTKD + + Sbjct: 1395 AQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG 1453 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT- 317 + +D L I DE Y C+A + AG+Q L+V A P I + N+T Sbjct: 1454 PHLQV--QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGSNETG 1510 Query: 318 --AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 A+ + V L CEA G P P+ITW + + K +V R L L Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQLGRA 1563 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAY 431 Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C + Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 1623 Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491 PS T+SW +G + SN S ++ S L + E G Y+C A + G+ L+ Sbjct: 1624 PSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679 Query: 492 F 492 + Sbjct: 1680 Y 1680 Score = 129 bits (324), Expect = 1e-29 Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GE +C V G + +SW +G L +Q+ + S TL I + DAGI Sbjct: 3328 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 3381 Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146 + CV G ++ T+ V++ L P EF+ D V+V + LP Sbjct: 3382 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 3433 Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204 P + W G ++ + + LQ+ + D GTY C + GE + Sbjct: 3434 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 3486 Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264 Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ + Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 3544 Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322 + + D Y C+AE+ AG + + ++V A P I + Sbjct: 3545 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 3596 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 Q+ L C +P P ITW I +E D H R L L+++ D+G+ Sbjct: 3597 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 3649 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D Sbjct: 3650 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709 Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 L P S I P S L + P D G+Y C A N G + Sbjct: 3710 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752 Score = 129 bits (324), Expect = 1e-29 Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 L I +A+ +DAG Y C+ GS T + + + +N EG A + C Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195 S P I W G+ V + +F + + L ++ ++ D GTY C GR Sbjct: 4061 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 4119 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 R + + V +P R LG + L C A G P P + WT + + Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 4170 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + ++ D S L V + D Y+C AEN+ G A + V P + Sbjct: 4171 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 4225 Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370 +E + + L C GDP+P I W DG + SH R SL Sbjct: 4226 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 4273 Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429 T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+ Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 4333 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G + Sbjct: 4334 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 4388 Query: 490 LEFILVQADTP 500 LV P Sbjct: 4389 ARAFLVVRGEP 4399 Score = 120 bits (300), Expect = 7e-27 Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P++ ++ G LC G + +I+W +G+ LT + ++S +T + Sbjct: 3502 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 3549 Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144 + DAG+Y C+ G+ E V V+ ++ P V+ C V + Sbjct: 3550 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608 Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202 P I W G ++L++D +LQ++ + D G Y C R A + F+ Sbjct: 3609 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666 Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ + Sbjct: 3667 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 3721 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322 + L I+ V D Y+C+A N AG L+V P I + + Sbjct: 3722 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 L CEASG P P + W + + + + ++ S+A L L + D+ + Sbjct: 3779 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 3833 Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441 + C SN +G+ + + V P + +T V +TC P+ T+SW + Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500 G L + Y + LE+ G Y C+A N G F+ VQA Sbjct: 3894 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 3949 Query: 501 SSP 503 P Sbjct: 3950 VKP 3952 Score = 113 bits (282), Expect = 8e-25 Identities = 118/471 (25%), Positives = 179/471 (38%), Gaps = 72/471 (15%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 ++VGE +C+ +G + I W+ E + + SS L I A D Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 759 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 AG Y C E G S A + + + P G A++ C PPT+ Sbjct: 760 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 818 Query: 151 WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205 W+ G+ + L+ + R + L + D+ Y CE R + G++ + Sbjct: 819 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 877 Query: 206 VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263 ++ + PP I + V GQ V+L C G P P W KDG + ++ Sbjct: 878 IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 932 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323 D S L + + + Y C+A N AG Q + L V P+I Sbjct: 933 SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 991 Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383 +L C ASG P P+ITW T ++S H V ++ +L + DAG Y Sbjct: 992 PASLPCVASGVPAPTITWTKETNALTSRGP----HYNV---SKEGTLLIAQPSAQDAGAY 1044 Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443 +CTA+NT+G SQ M L V + ++ Y WE + Sbjct: 1045 VCTATNTVGFSSQEMRLSVN-----RLALSKYVWE----------------------EYG 1077 Query: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 LLPS + L + D G+Y CTA N G S ++L Sbjct: 1078 LLPSGS--------------LRLAQVQVGDSGHYECTASNPAGSASHRYVL 1114 Score = 110 bits (274), Expect = 7e-24 Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%) Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86 GE++V E LC+ G +I+WF L P ++ L + A Sbjct: 1510 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 1563 Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143 DAG+Y C + G+ +AT + ++ + A P + G + C Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622 Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 PT+ W H+G V + R + + L++ + G Y C A GE + Sbjct: 1623 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 1679 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ + Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 1737 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320 + + L I V+ + + C A N+AG A + + V + P + V Q Sbjct: 1738 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 1796 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374 E + A+ DP W + E G + + +++ L ++ Sbjct: 1797 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 1854 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433 + D G Y C A+N G+ + + L+V P ++ GPV E V + C P Sbjct: 1855 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 1914 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 +SWF+ Q P S++ + + + L + +D G+Y C A N G L + Sbjct: 1915 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969 Score = 108 bits (270), Expect = 2e-23 Identities = 127/523 (24%), Positives = 191/523 (36%), Gaps = 92/523 (17%) Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEF--REGED 134 + +L + A + AG Y CV T GS+ +V++ ++ + PT EG Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTAGSQHR---DVELVVQVPPRIHPTATHHITNEGVP 992 Query: 135 AVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC---- 189 A + C V S +P PTI W K + + + + V L I D G Y C Sbjct: 993 ASLPC-VASGVPAPTITWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050 Query: 190 ------------------------EGRILARGEINFKDIQVI------------------ 207 E +L G + +QV Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110 Query: 208 -----VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 V VPP +Q ++ +G+++ L C AEG PEP +SW+KDG ++ Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVL--VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-- 320 F+ + +D Y C A N AG + L+V P E +E Sbjct: 1169 VHFA---------AIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380 E +L C A G P P +TWR + SSE L G V + SL L S+ D+ Sbjct: 1220 AGENASLPCPARGTPKPQVTWR---KGPSSEP--LHGQPGV-AVLEEGSLFLASVSPADS 1273 Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437 G+Y C A+N +G S+ L V P ++ V G + + C+ +P I Sbjct: 1274 GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333 Query: 438 WFRDGQLLP----------SSNYSNIKIYNT-PSASYLEVTPDSENDFGNYNCTAVNRIG 486 W +D QL+ + + + L E D G Y+C A N+ G Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393 Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVP 529 +F L+ PS + A + T GVP Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436 Score = 108 bits (270), Expect = 2e-23 Identities = 110/461 (23%), Positives = 181/461 (39%), Gaps = 40/461 (8%) Query: 55 FSPNGEKLTPNQQRIS-VVWNDDS---SSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110 FS +L+ N+ +S VW + S +L + + D+G Y+C + GS S V Sbjct: 1054 FSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1113 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 + + + P + GE + C + P + W G V+L+ Sbjct: 1114 -LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDG--VVLQGRG-----P 1165 Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230 + I+ +D G YRCE A ++ ++++ V PP A + G++ Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSA--GVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223 Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290 +L C A G P+P ++W K G E ++ S L + V D +Y C A Sbjct: 1224 ASLPCPARGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQAT 1281 Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI 348 N+ G L V+ P I + + + +TL C+A+G P+P I W + + Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341 Query: 349 SSE-----------EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397 + GH ++ SL IQ D+G Y C A N G + Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQAGTAQRD 1398 Query: 398 MYLEVQYAPKLQGPVA---VYTWEGNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNI 453 +L V P + G A V G V + C P+ + W +D Q +LP + + Sbjct: 1399 FHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQV 1458 Query: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 + L +T D G Y C A + GQ++ +F L Sbjct: 1459 Q----EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 1495 Score = 107 bits (268), Expect = 4e-23 Identities = 90/366 (24%), Positives = 148/366 (40%), Gaps = 25/366 (6%) Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195 ++ C V S+LP + + + + L ++ F N+ +I K +EGTY C + Sbjct: 445 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 501 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 G K V+ + PP + N+ T + G++ L C G ++W +D + Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 558 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + L I + D Y C+A N G A++ L V P+++ + Sbjct: 559 ASTGRVAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 615 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 +V ++C ASG P P I+W S E + L + A+ +L ++ + Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 667 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSA 434 DAG Y C A+N +G D +++ L P + AV G + + CE P Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727 Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 + W+R G + I S+ L + E D G Y C AVN +G S E L Sbjct: 728 RVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780 Query: 495 VQADTP 500 P Sbjct: 781 AVGHAP 786 Score = 105 bits (261), Expect = 2e-22 Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG Sbjct: 4052 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 4105 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C G + V++ I +F P + R G+ + C S P I W Sbjct: 4106 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164 Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208 R V + ++D + LQ + + D GTY C E R+ ++F V V Sbjct: 4165 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 4214 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 P +Q + +G S+ L C G P P + W KDG + + Sbjct: 4215 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 4269 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 + LTI + +++D Y C+AEN+ G + L + + P + + V L Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329 Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 4378 Query: 386 TASNTIGQDSQSMYLEVQYAPK 407 A N +G + +L V+ P+ Sbjct: 4379 VAHNLLGSATARAFLVVRGEPQ 4400 Score = 102 bits (255), Expect = 1e-21 Identities = 107/441 (24%), Positives = 183/441 (41%), Gaps = 42/441 (9%) Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134 + L I +++ D G Y+CV G ++ + + V + N E Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 1519 Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRCEG-R 192 ++C+ P I W G +L + + LQ+ + +D G Y C+ Sbjct: 1520 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577 Query: 193 ILARGEINFKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249 + E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW Sbjct: 1578 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 1632 Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309 +G + + + D S L ++ + Y C+A + AGE ++V P+ Sbjct: 1633 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 1689 Query: 310 ITYVEN--QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 + E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++ Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 1742 Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424 ++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + + Sbjct: 1743 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 1801 Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473 + P W +G P S + + I + Y+ P L++ D Sbjct: 1802 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 1859 Query: 474 FGNYNCTAVNRIGQESLEFIL 494 G Y C A N G+ E L Sbjct: 1860 EGIYTCAATNLAGESKREVAL 1880 Score = 89.0 bits (219), Expect = 2e-17 Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%) Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 +E++ +S I + K +E Y C A ++AG A + V P + Sbjct: 469 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 528 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374 E L+C G+ ++TW D ++ S RV+ SL + Sbjct: 529 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 576 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429 I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C Sbjct: 577 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 632 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G + Sbjct: 633 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 687 Query: 490 LEFILVQADTPSSPSIDQV 508 L D PS +++ V Sbjct: 688 ETVTLYYTDPPSVSAVNAV 706 Score = 43.5 bits (101), Expect = 8e-04 Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%) Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 426 SS + + G Y CTA + G + V P P T G ++C Sbjct: 479 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 538 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 V ++W RD ++LP+S ++ + LE++ D G Y C A N G Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 594 Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546 L+ + P + +S +V+ + P + + E +A+ E+ Sbjct: 595 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 651 Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 +G + I G+ PE A N G + + + P Sbjct: 652 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 698 >gi|4506569 roundabout 1 isoform a [Homo sapiens] Length = 1651 Score = 154 bits (390), Expect = 3e-37 Identities = 193/733 (26%), Positives = 279/733 (38%), Gaps = 85/733 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 74 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 131 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 190 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 191 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 247 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 248 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317 +Y DD + L I+KV D Y C+AEN G+ +A+ L V P Sbjct: 306 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372 + L VT CEA+G+P P+I WR + L + +S +R S LT+ Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415 Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425 ++Q +D G YIC N G YLEV P + QGPV ++ Sbjct: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475 Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 476 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 531 Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530 G+ E EF + VQ PS+PS +V S +P G Sbjct: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591 Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590 Y E S W E I GLKP Y + A N G+ + S Sbjct: 592 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648 Query: 591 SE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPIRHY 635 S+ KTQ P +++ ++G +SI+V+ D I+ Y Sbjct: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGY 707 Query: 636 LVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAAH 687 + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 708 KILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIK 766 Query: 688 FVFRTSAQPTAIP 700 F P+A P Sbjct: 767 FAKTLEEAPSAPP 779 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 242 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 243 TNMVGERESE 252 >gi|224994173 roundabout 1 isoform d [Homo sapiens] Length = 1551 Score = 150 bits (380), Expect = 4e-36 Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314 +Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+ Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369 + L VT CEA+G+P P+I WR + L + +S +R S Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422 LT+ ++Q +D G YIC N G YLEV P + QGPV Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 ++C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492 Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527 G+ E EF + VQ PS+PS +V S +P G Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552 Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587 Y E S W E I GLKP Y + A N G+ + Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609 Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632 S S+ KTQ P +++ ++G +SI+V+ D I Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668 Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684 + Y + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727 Query: 685 AAHFVFRTSAQPTAIP 700 F P+A P Sbjct: 728 EIKFAKTLEEAPSAPP 743 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 204 TNMVGERESE 213 >gi|224994171 roundabout 1 isoform c [Homo sapiens] Length = 1606 Score = 150 bits (380), Expect = 4e-36 Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314 +Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+ Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369 + L VT CEA+G+P P+I WR + L + +S +R S Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422 LT+ ++Q +D G YIC N G YLEV P + QGPV Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 ++C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492 Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527 G+ E EF + VQ PS+PS +V S +P G Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552 Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587 Y E S W E I GLKP Y + A N G+ + Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609 Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632 S S+ KTQ P +++ ++G +SI+V+ D I Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668 Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684 + Y + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727 Query: 685 AAHFVFRTSAQPTAIP 700 F P+A P Sbjct: 728 EIKFAKTLEEAPSAPP 743 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 204 TNMVGERESE 213 >gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo sapiens] Length = 1562 Score = 150 bits (380), Expect = 4e-36 Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314 +Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+ Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369 + L VT CEA+G+P P+I WR + L + +S +R S Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422 LT+ ++Q +D G YIC N G YLEV P + QGPV Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 ++C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492 Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527 G+ E EF + VQ PS+PS +V S +P G Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552 Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587 Y E S W E I GLKP Y + A N G+ + Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609 Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632 S S+ KTQ P +++ ++G +SI+V+ D I Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668 Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684 + Y + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727 Query: 685 AAHFVFRTSAQPTAIP 700 F P+A P Sbjct: 728 EIKFAKTLEEAPSAPP 743 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 204 TNMVGERESE 213 >gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo sapiens] Length = 1615 Score = 150 bits (380), Expect = 4e-36 Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80 PS +S GE C+ G I W+ GE++ P R+ + Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92 Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 + + D G+Y CV G A++ V I + F+ P+ GE AV+ Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151 Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 C P PTI WK G + KD R I + L I +K+D G Y C G + G Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 E + ++ V P+ R + N + S C+A G P PT+ W KD ++ + Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314 +Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+ Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369 + L VT CEA+G+P P+I WR + L + +S +R S Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422 LT+ ++Q +D G YIC N G YLEV P + QGPV Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 ++C P TI W +DG +L S+ S IK L++ D G Y C A Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492 Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527 G+ E EF + VQ PS+PS +V S +P G Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552 Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587 Y E S W E I GLKP Y + A N G+ + Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609 Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632 S S+ KTQ P +++ ++G +SI+V+ D I Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668 Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684 + Y + YR S+W E+R P+ + V++ L YE+ QG Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727 Query: 685 AAHFVFRTSAQPTAIP 700 F P+A P Sbjct: 728 EIKFAKTLEEAPSAPP 743 Score = 58.5 bits (140), Expect = 2e-08 Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 P+I + + E TL C+A G P P+I W + +++ H ++ + Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88 Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422 L + + + D G Y+C A N +G+ + S+ + + Q P V G Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148 Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 + C+ +P TISW +DG L + T L +T ++D G Y C Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203 Query: 482 VNRIGQESLE 491 N +G+ E Sbjct: 204 TNMVGERESE 213 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 145 bits (366), Expect = 2e-34 Identities = 113/473 (23%), Positives = 211/473 (44%), Gaps = 35/473 (7%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C++ G + K + W+ E ++ R+S V DS + L ++N +++D+G Y C Sbjct: 7327 CKIGGSPEIK-VLWYKDETEIQESSKFRMSFV---DSVAVLEMHNLSVEDSGDYTCEAHN 7382 Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160 GS S +T ++K+ + +F+ P P E +G D + C++ + P + W R+ L Sbjct: 7383 AAGSASSST-SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRE--L 7439 Query: 161 KKDVRFIVLSNNYL---QIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQ 215 + ++ ++S N+L I + D G Y+C+ A ++ + + PP Sbjct: 7440 RSGKKYKIMSENFLTSIHILNVDAADIGEYQCK----ATNDVGSDTCVGSIALKAPPRFV 7495 Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275 + + ++ +G+ V L EG ++ W KD +I +E D+ +S++ + L Sbjct: 7496 KKLSDISTV--VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS 7553 Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP 335 +V+ + +Y C +N AG Q+ L V I + + TL C +G P Sbjct: 7554 RVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613 Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395 S W + ++S+ K + +VS L + ++ +D+G Y N +G+DS Sbjct: 7614 ELSTKWFKDGKELTSDNK-----YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDS 7668 Query: 396 QSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448 + L+V + KL+ + G+ V + C+V+ P ++SWF +G + S Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGL---SGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725 Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 + T + L V E+D G+Y C A N G + L + PS Sbjct: 7726 RKYQTTL--TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS 7776 Score = 144 bits (362), Expect = 4e-34 Identities = 127/533 (23%), Positives = 226/533 (42%), Gaps = 41/533 (7%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P +++ G++ C VAG + WF E + N+ +IS + S L I N Sbjct: 7592 PESIKVTTGDTCTLECTVAG-TPELSTKWFKDGKELTSDNKYKISFF---NKVSGLKIIN 7647 Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVV 142 D+G+Y V G +S T ++++ + + F G V+ C V Sbjct: 7648 VAPSDSGVYSFEVQNPVGKDS-CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY 7706 Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINF 201 S P ++ W H+G ++ + + + N L + ++++D G Y C +A + Sbjct: 7707 GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDEC- 7765 Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261 + V PP+ + + ++ G +VT +G P ++SW K ++ D Sbjct: 7766 -SAPLTVREPPSFVQKPDPMDVLT--GTNVTFTSIVKGTPPFSVSWFKGSSELVPG-DRC 7821 Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321 D ++L + VD + EY CI N+AG+ T HL + A K N ++E Sbjct: 7822 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEK 7881 Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381 + + L +G P S+TW+ + N++ ++ + + + + L + S DAG Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQR-----CNITTTEKSAILEIPSSTVEDAG 7936 Query: 382 EYICTASNTIGQDS---QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438 +Y C N G+DS Q + LE Y K PV V G+ ++ C++ P +SW Sbjct: 7937 QYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSV--GDSASLQCQLAGTPEIGVSW 7994 Query: 439 FR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 ++ D +L P++ Y K++ + + L ND G Y C A N +G+ S L Sbjct: 7995 YKGDTKLRPTTTY---KMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051 Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550 + PS + Q + + T G+P++ + G E WY Sbjct: 8052 EQKLPPSFSR----------QLRDVQETVGLPVV---FDCAISGSEPISVSWY 8091 Score = 134 bits (337), Expect = 4e-31 Identities = 131/551 (23%), Positives = 221/551 (40%), Gaps = 52/551 (9%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 G+S F CQ+ G K + +SW+ E + IS + D +T I A ++++G Sbjct: 4876 GQSTTFECQITGTPKIR-VSWYLDGNEITAIQKHGISFI---DGLATFQISGARVENSGT 4931 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C + G+ S ++ +K+ + F P E + D + C+V + P + W Sbjct: 4932 YVCEARNDAGTAS-CSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990 Query: 154 KGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPP 212 R++ K + + L I +D G Y+C + G +V + PP Sbjct: 4991 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCI--VSNEGGSCSCSTRVALKEPP 5048 Query: 213 TIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQ 271 + + I N T L S T G P +++W KD + ++ EDD YI F D + Sbjct: 5049 SFIKK--IENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD--EDDNVYISFVDSVAT 5104 Query: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331 L I+ VD Y C A+N++G + L V +I + ++ +TL C Sbjct: 5105 LQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV 5164 Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391 +G P + W + I + + V+S ++S+ D+G+Y N Sbjct: 5165 AGTPELKVKWLKDGKQIVPSR-----YFSMSFENNVASFRIQSVMKQDSGQYTFKVENDF 5219 Query: 392 GQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444 G S YL V + KL V G+ +++ C+V + WF+DG+ Sbjct: 5220 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPISAQWFKDGKE 5276 Query: 445 LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS--- 501 + +S + ++ + LEV D NY C N G ++ IL + PS Sbjct: 5277 ISTS--AKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV 5334 Query: 502 SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561 P Q P S+ V+F ILK G + KW+ + G Sbjct: 5335 KPGRQQAIPDST---VEFK--------AILK--------GTPPFKIKWFKDDVELVSGPK 5375 Query: 562 TIVGLKPETTY 572 +GL+ T++ Sbjct: 5376 CFIGLEGSTSF 5386 Score = 129 bits (325), Expect = 9e-30 Identities = 133/584 (22%), Positives = 234/584 (40%), Gaps = 32/584 (5%) Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82 D+ P ++++GES F C V G A K I+W N E ++++V ++++TLT Sbjct: 7215 DLKPVSVDLALGESGTFKCHVTGTAPIK-ITWAKDNREIRPGGNYKMTLV---ENTATLT 7270 Query: 83 IYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141 + DAG Y C + G +S A + V+ + + K P+ + ++ E C + Sbjct: 7271 VLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS-RIVKQDEFTRYECKI 7329 Query: 142 VSSLPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200 S ++W ++ R V S L++ + D G Y CE A + Sbjct: 7330 GGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASS 7389 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260 ++ V PP + + + + G V L C+ +G P +SW KD ++ Sbjct: 7390 STSLK--VKEPPIFRKKPHPIETLK--GADVHLECELQGTPPFHVSWYKDKREL---RSG 7442 Query: 261 EKYIFSDDS--SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 +KY ++ + + I VD D EY C A N G + + A P+ + + Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIS 7502 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 + ++V L G S+ W I E ++ + +++L ++ Sbjct: 7503 TVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRE----SDNIWISYSENIATLQFSRVEPA 7558 Query: 379 DAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 +AG+Y C N G L V + A ++ P ++ G+ + C V P + Sbjct: 7559 NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTK 7618 Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 WF+DG+ L S N I +N S L++ + +D G Y+ N +G++S L + Sbjct: 7619 WFKDGKELTSDNKYKISFFN--KVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVS 7676 Query: 498 DTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553 D PS + + S ++ V E + G PI W G E+ + Y Sbjct: 7677 DRTVPPSFTRKLKETNGLSGSSVVM--ECKVYGSPPI---SVSWFHEGNEISSGRKYQTT 7731 Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 +T+ L+ + A N G E SA + P Sbjct: 7732 LTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPP 7775 Score = 129 bits (323), Expect = 1e-29 Identities = 111/481 (23%), Positives = 209/481 (43%), Gaps = 37/481 (7%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GES C+++G + K +SWF + E + +S + +S + LTI A+ +D+G Sbjct: 6379 GESIQLECKISGSPEIK-VSWFRNDSELHESWKYNMSFI---NSVALLTINEASAEDSGD 6434 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C G S +T + + +F P+P +G D ++ C++ + P ++W Sbjct: 6435 YICEAHNGVGDASCSTA-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493 Query: 154 KGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210 + V + +F + S ++ L I ++ +D G Y C+ A E+ V Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCK----ATNEVGSDTCSCSVKF 6547 Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270 + + + + + +G +V L EGF ++ W KD ++ +E ++ + F D+ + Sbjct: 6548 KEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIA 6607 Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330 L + + ++ +YIC +N AG ++ + L V +I + L C Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECV 6667 Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390 +G P S W R +S++ K H + + +V+SL + + +D G Y N+ Sbjct: 6668 VTGTPELSAKWFKDGRELSADSK----HHITFIN-KVASLKIPCAEMSDKGLYSFEVKNS 6722 Query: 391 IGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443 +G+ + ++ + V + KL+ A+ G V + C V ++ WF+DG Sbjct: 6723 VGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL---GASVVLECRVSGSAPISVGWFQDGN 6779 Query: 444 LL---PSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 + P S + T + S LE +D G Y C A N G + +L + P Sbjct: 6780 EIVSGPKCQSSFSENVCTLNLSLLE-----PSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834 Query: 501 S 501 S Sbjct: 6835 S 6835 Score = 127 bits (319), Expect = 4e-29 Identities = 120/532 (22%), Positives = 200/532 (37%), Gaps = 39/532 (7%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I WF + E ++ + I + + S+S L +Y+ + G Y C VT + GS+S T+ Sbjct: 5361 IKWFKDDVELVSGPKCFIGL---EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417 Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-S 170 + K + + G+ + + C + S ++W ++ R + S Sbjct: 5418 LVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDS 5477 Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230 +Q+ + D G + CE + A +VIV PP + IV N Sbjct: 5478 VAVIQMNNLSTEDSGDFICEAQNPAGS--TSCSTKVIVKEPPVFSSFPPIVETLKN--AE 5533 Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290 V+L C+ G P + W KD Q+ + K + + + I VD +D EY C A+ Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592 Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISS 350 N+ G +K+ P+ N + E L G + W + Sbjct: 5593 NEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652 Query: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS---MYLEVQYAPK 407 E + + V V++L + +AG+YIC N G M LE + Sbjct: 5653 ESENIRITFV----ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVE 5708 Query: 408 LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467 GP+ V G + C+V P ++ W++DG+LL SS YN S L + Sbjct: 5709 KAGPMTVTV--GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN--KISSLRIL 5764 Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGG 527 D G Y N +G+ S ++ +D PS + + TGG Sbjct: 5765 SVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTR-------------RLKNTGG 5811 Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579 V E + G W+ K + G K +TT++ + L Sbjct: 5812 VLGASCILECKVAGSSPISVAWFHEKTK------IVSGAKYQTTFSDNVCTL 5857 Score = 127 bits (319), Expect = 4e-29 Identities = 103/483 (21%), Positives = 208/483 (43%), Gaps = 35/483 (7%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 + G+S C++AG + + + WF E ++ R++ + DS + + + N + +D Sbjct: 5435 VKAGDSSRLECKIAGSPEIR-VVWFRNEHELPASDKYRMTFI---DSVAVIQMNNLSTED 5490 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 +G + C GS S +T V + + +F + P E + + + C++ + P ++ Sbjct: 5491 SGDFICEAQNPAGSTSCST-KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549 Query: 151 WKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207 W R L+ ++ + S N+ + I + +D G Y C+ A+ E+ Sbjct: 5550 WYKDKRQ--LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCK----AQNEVGSDTCVCT 5603 Query: 208 VNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265 V + PP ++ N + A G+ L EG + W K+ E++ +E ++ + F Sbjct: 5604 VKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661 Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325 ++ + L K + + +YIC +N G ++ L V I + + E Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETC 5721 Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 TL C+ +G P S+ W + ++S +K + ++SSL + S++ DAG Y Sbjct: 5722 TLECKVAGTPELSVEWYKDGKLLTSSQK-----HKFSFYNKISSLRILSVERQDAGTYTF 5776 Query: 386 TASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438 N +G+ S + ++V + +L+ V G + C+V +++W Sbjct: 5777 QVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL---GASCILECKVAGSSPISVAW 5833 Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498 F + + S + + + + L++ +D GNY C A N G + +L + Sbjct: 5834 FHEKTKIVSG--AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891 Query: 499 TPS 501 PS Sbjct: 5892 PPS 5894 Score = 126 bits (316), Expect = 1e-28 Identities = 119/475 (25%), Positives = 200/475 (42%), Gaps = 26/475 (5%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 GES C++ G + ++WF N E N R+ V +S + L I + ++D+G Sbjct: 3752 GESARLHCKLKGSPVIQ-VTWFKNNKELSESNTVRMYFV---NSEAILDITDVKVEDSGS 3807 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C + GS+S +T + I + F P + G +A++ C+V + P I W Sbjct: 3808 YSCEAVNDVGSDSCST-EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFK 3866 Query: 154 KGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV--IVNV 210 + + K R F S L+I D G Y C + E+ ++ Sbjct: 3867 DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC----VVANEVGKCGCMATHLLKE 3922 Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270 PPT + + + A GQ+VTL G +++W K G+++ +E+ K FS+ + Sbjct: 3923 PPTFVKKVDDLIALG--GQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFSNGVA 3979 Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330 L I V + +Y C+AEN+AG Q + L V KI + + TL Sbjct: 3980 VLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039 Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390 +G P W R + + +K + V+ L S + D+G+Y SN Sbjct: 4040 VAGTPELKPKWYKDGRPLVASKK-----YRISFKNNVAQLKFYSAELHDSGQYTFEISNE 4094 Query: 391 IGQDS---QSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446 +G S L+ AP P+ V + + C++ +SWF+DG+ + Sbjct: 4095 VGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA 4154 Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 +S+ +I + LE+ ND GN+ C A N +G + L+ + PS Sbjct: 4155 ASD--RYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPS 4207 Score = 124 bits (310), Expect = 5e-28 Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 26/469 (5%) Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89 E +VG+S CQVAG + +SW+ KL P + + N + +TL NI+ Sbjct: 6089 EAAVGDSVSLQCQVAG-TPEITVSWYK-GDTKLRPTPEYRTYFTN--NVATLVFNKVNIN 6144 Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVVSSLP 146 D+G Y C G+ S TV +I ++ + F E G + C + S P Sbjct: 6145 DSGEYTCKAENSIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAP 6203 Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD---EGTYRCE-GRILARGEINFK 202 + W G V+L+ D + + I +TD G Y C L + + Sbjct: 6204 IQVCWYRDG--VLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSAR 6261 Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262 P + ++ A G+S C G ++W+KD ++I + + Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKEI-RPGGNYT 6318 Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK-ITYVENQTAMEL 321 ++ L I KV K D +Y C A N G+ + L V PK + +E + Sbjct: 6319 ITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ 6378 Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381 E + L C+ SG P ++W RN S ++ +M + V+ LT+ D+G Sbjct: 6379 GESIQLECKISGSPEIKVSW---FRNDSELHESWKYNMSFIN--SVALLTINEASAEDSG 6433 Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440 +YIC A N +G S S L V+ P Q P V +G+ V + CE+ P + W + Sbjct: 6434 DYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493 Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 D + + N KI + + L + +D G Y+C A N +G ++ Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540 Score = 120 bits (301), Expect = 5e-27 Identities = 127/548 (23%), Positives = 216/548 (39%), Gaps = 41/548 (7%) Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92 +G S C+V+G A + WF E ++ + + S ++ TL + D G Sbjct: 6754 LGASVVLECRVSGSAPIS-VGWFQDGNEIVSGPKCQSSF---SENVCTLNLSLLEPSDTG 6809 Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152 IY CV GS+ E + + + + F+ P E G V+ PP + Sbjct: 6810 IYTCVAANVAGSD-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVIRGTPPFKVKW 6867 Query: 153 HKGRDVILKKDVRFIVLSN--NYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIV 208 KG ++ + I L + L++ ++ + G Y C L + + V Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSC----LVTNDAGSASCTTHLFV 6923 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 P T R + + + G + L G P ++SW KD I Q E ++ Sbjct: 6924 KEPATFVKR--LADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS-ITMTEK 6980 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 S+ L I + D A+Y C+ EN+AG+ + V P + E TL Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQ 7040 Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388 C+ G P I+W + S ++ V+SL + + ++D GEY C A Sbjct: 7041 CKVDGTPEIRISWYKEHTKLRSAPA-----YKMQFKNNVASLVINKVDHSDVGEYSCKAD 7095 Query: 389 NTIGQDSQSMYLEVQ-------YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 N++G + S L ++ +A KL+ V+ G V C + +SW++D Sbjct: 7096 NSVGAVASSAVLVIKARKLPPFFARKLKD---VHETLGFPVAFECRINGSEPLQVSWYKD 7152 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADT 499 G LL +N++ + + L++ ++ G YNC+A N +G S + IL + + Sbjct: 7153 GVLLKDD--ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEV 7210 Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P + V + + + TG PI K W E+ Y K +E Sbjct: 7211 PPFFDLKPVSVDLALGESGTFKCHVTGTAPI---KITWAKDNREIRPGGNY--KMTLVEN 7265 Query: 560 IVTIVGLK 567 T+ LK Sbjct: 7266 TATLTVLK 7273 Score = 119 bits (298), Expect = 1e-26 Identities = 121/537 (22%), Positives = 204/537 (37%), Gaps = 38/537 (7%) Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135 + + L I N+ DAG Y C + E G + + V + F P E G+ Sbjct: 6038 EKTCILEILNSTKRDAGQYSCEIENEAGRDVCGAL-VSTLEPPYFVTELEPLEAAVGDSV 6096 Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRI 193 + C V + T+ W +KG + +NN L + D G Y C+ Sbjct: 6097 SLQCQVAGTPEITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK--- 6152 Query: 194 LARGEINFKDIQVIVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248 A I + + + PP+ + + T +G VTL C G + W Sbjct: 6153 -AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWY 6209 Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 +DG + +E+ + F D+ + L I + D + +Y C A N G ++ L Sbjct: 6210 RDGVLLRDDENLQTS-FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPK 6268 Query: 309 KITYVENQTA---MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365 K + + + + E C +G ITW + I G+ + Sbjct: 6269 KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRP-----GGNYTITCVG 6323 Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVAVYTWEGNQVN 423 L + + D+G+Y C A+N +G+D S L V+ PK + + +G + Sbjct: 6324 NTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQ 6383 Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483 + C++ P +SWFR+ L S N+ N S + L + S D G+Y C A N Sbjct: 6384 LECKISGSPEIKVSWFRNDSELHESWKYNMSFIN--SVALLTINEASAEDSGDYICEAHN 6441 Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD---EPEATGGVPILKYKAEWRAV 540 +G S L T +P + +P A D + E +G P ++ W Sbjct: 6442 GVGDASCSTAL----TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPP---FEVVWVKD 6494 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 ++V +SK + + + I+ L+ A N G S + +FK P Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPP 6551 Score = 117 bits (292), Expect = 6e-26 Identities = 123/517 (23%), Positives = 201/517 (38%), Gaps = 33/517 (6%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C+++G ++ W+ + + + +I+ + + +++ I N + D G Y C Sbjct: 5538 CELSG-TPPFEVVWYKDKRQLRSSKKYKIA---SKNFHTSIHILNVDTSDIGEYHCKAQN 5593 Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160 E GS++ VK+ + F + GE A + + + P + W + +VI Sbjct: 5594 EVGSDT-CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652 Query: 161 KKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218 + + I N LQ + + G Y C+ I G + ++V P I + Sbjct: 5653 ESENIRITFVENVATLQFAKAEPANAGKYICQ--IKNDGGMRENMATLMVLEPAVIVEKA 5710 Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278 + T +G++ TL C G PE ++ W KDG+ + + K+ F + S L I V+ Sbjct: 5711 GPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQK-HKFSFYNKISSLRILSVE 5767 Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAK---PKITYVENQTAMELEEQVTLTCEASGDP 335 + D Y +N G+ T + V + P T T L L C+ +G Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827 Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395 S+ W I S K V +L L S+ +D G Y C A+N G D Sbjct: 5828 PISVAWFHEKTKIVSGAK-----YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDE 5882 Query: 396 QSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454 L VQ P ++ P + G V T + P ++WFR + L + NI Sbjct: 5883 CRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNI- 5941 Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE---FILVQADTPSSPSIDQVEPY 511 Y + + LE+ + G Y C N GQ S F+ A S VEP Sbjct: 5942 -YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPG 6000 Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548 S E TG +PI W+ G + S+ Sbjct: 6001 KSIIL----ESTYTGTLPI---SVTWKKDGFNITTSE 6030 Score = 114 bits (285), Expect = 4e-25 Identities = 136/583 (23%), Positives = 223/583 (38%), Gaps = 30/583 (5%) Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82 DI P ++ GES F C V G A+ I+W N E I+ V N + L Sbjct: 6274 DIKPVSIDVIAGESADFECHVTG-AQPMRITWSKDNKEIRPGGNYTITCVGN---TPHLR 6329 Query: 83 IYNANIDDAGIYKCVVTGEDGSE-SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141 I D+G Y C T + G + A ++VK K + K + ++GE + C + Sbjct: 6330 ILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFV-KKLEASKVAKQGESIQLECKI 6388 Query: 142 VSSLPPTIIWKHKGRDV--ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199 S + W ++ K ++ FI S L I D G Y CE G+ Sbjct: 6389 SGSPEIKVSWFRNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAH-NGVGDA 6446 Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 + + V PP + + V A G V L C+ G P + W KD +Q+ + Sbjct: 6447 SC-STALTVKAPPVFTQKPSPVGALK--GSDVILQCEISGTPPFEVVWVKDRKQVRNSK- 6502 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 K + L I ++ +D EY C A N+ G + +K P+ + T+ Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTST 6562 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 + + V L G S+ W + E + + +++L L S + ++ Sbjct: 6563 LIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI----DNIATLQLGSPEASN 6618 Query: 380 AGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438 +G+YIC N G S L V + A ++ P + GN + C V P + W Sbjct: 6619 SGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW 6678 Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498 F+DG+ L + + +I N + L++ +D G Y+ N +G+ + + +D Sbjct: 6679 FKDGRELSADSKHHITFIN--KVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736 Query: 499 TPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554 PS + V + V E +G PI W G E+ + Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVL--ECRVSGSAPI---SVGWFQDGNEIVSGPKCQSSF 6791 Query: 555 ASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 + + + L+P T A N G E SA + P Sbjct: 6792 SENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834 Score = 112 bits (279), Expect = 2e-24 Identities = 124/562 (22%), Positives = 218/562 (38%), Gaps = 44/562 (7%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C++AG + +SWF E ++ RI+ V + +++L I +++DAG + C T Sbjct: 4134 CKIAGSLPMR-VSWFKDGKEIAASDRYRIAFV---EGTASLEIIRVDMNDAGNFTCRATN 4189 Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160 GS+ + + + + F P ++ G + S P TI W KG ++ Sbjct: 4190 SVGSKDSSGALI-VQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW-FKGNKELV 4247 Query: 161 KKDVRFIVLS--NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218 +I + L++ +K +D GTY C+ +A G ++ V P T + Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL--FVKEPATFVEKL 4305 Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278 + G + L C G P ++W + +I+ E + F + ++ L + V Sbjct: 4306 E-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIK-ESSKHRMSFVESTAVLRLTDVG 4363 Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338 D EY+C A+N+AG + + V P T + E V L E +G P Sbjct: 4364 IEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFE 4423 Query: 339 ITW---RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395 ITW T R+ + + H+V SL + DAGEY C +N +G Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLV--------SLQILKFVAADAGEYQCRVTNEVGSSI 4475 Query: 396 QSMYLEVQYAPKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454 S + ++ P + + + G + T++W +D + + + Sbjct: 4476 CSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMT 4535 Query: 455 IYNTPSASYL---EVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD----TPSSPSIDQ 507 N ++ YL EV D G Y C A N G + +L + T + SID Sbjct: 4536 FENNVASLYLSGIEVKHD-----GKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDV 4590 Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567 + +T QV+F + + A+W G+E+ Y I+ I+ + Sbjct: 4591 TQGDPATLQVKFSGTK--------EITAKWFKDGQELTLGSKYKISVTDTVSILKIISTE 4642 Query: 568 PETTYAVRLAALNGKGLGEISA 589 + + N G A Sbjct: 4643 KKDSGEYTFEVQNDVGRSSCKA 4664 Score = 111 bits (277), Expect = 3e-24 Identities = 159/648 (24%), Positives = 254/648 (39%), Gaps = 81/648 (12%) Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89 ++SVG+S CQ+AG + +SW+ + KL P N+ +TL +I+ Sbjct: 7971 KVSVGDSASLQCQLAG-TPEIGVSWYKGD-TKLRPTTTYKMHFRNN--VATLVFNQVDIN 8026 Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE--GEDAVIVCDVVSSLPP 147 D+G Y C G S +T QKL + ++ +E G V C + S P Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086 Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDE---GTYRCEG-RILARGEINFKD 203 ++ W G+ + +V+ L N I KTD G Y C + + + Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNT--ATLNIFKTDRSLAGQYSCTATNPIGSASSSARL 8144 Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 I PP R V+A +G+S C G +SW KD +I KY Sbjct: 8145 ILTEGKNPPFFDIRLAPVDAV--VGESADFECHVTGTQPIKVSWAKDSREIRS---GGKY 8199 Query: 264 IFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV---FAKPKITYVENQTA 318 S ++S+ LT+ KVDK D +Y C A N+ G+ T L + P T ++T Sbjct: 8200 QISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETV 8259 Query: 319 MELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 E E L +G ++ W + I + T + + +++ V L ++ Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKNNIEI---QPTSNCEITFKNNTLV--LQVRKAGM 8314 Query: 378 TDAGEYICTASNTIGQD--SQSMYLEVQYAPKL--QGPVAVYTWEGNQVNITCEVFAYPS 433 DAG Y C SN G + S+ ++ P + Q V EG V ++C V Sbjct: 8315 NDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEP 8374 Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493 I W + G+ + S+ + + LE+ ++ D G+Y C A N G ++ + Sbjct: 8375 IRIQWLKAGREIKPSDRCSFSF--ASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSK 8432 Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQ-----FDEPEA--------------TGGVPI--LK 532 + D P+ V P + A V EP++ GG PI +K Sbjct: 8433 VTIKDKPA------VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVK 8486 Query: 533 Y-KAEWRAV---GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-- 586 + K +WR + G H K +AK + T GL R A N G E Sbjct: 8487 WTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGL-------YRCVAFNEHGEIESN 8539 Query: 587 --ISAASEFKTQPVQGEPSA-----PKLEGQMGEDGNSIKVNLIKQDD 627 + K + ++G+ A P L+ GE+ + L+K D Sbjct: 8540 VNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVD 8587 Score = 105 bits (263), Expect = 1e-22 Identities = 121/557 (21%), Positives = 208/557 (37%), Gaps = 36/557 (6%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATV 110 ++W + E + R++ +++ ++L + + G Y C + G + A + Sbjct: 4517 VTWLKDSDEITEDDNIRMTF---ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 +VK + + +G+ A + + T W G+++ L + V Sbjct: 4574 SVK--EPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTD 4631 Query: 171 N-NYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNAT 224 + L+I +K D G Y E GR + IN D+ + PP+ + +++ Sbjct: 4632 TVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLII----PPSFTKKLKKMDSI 4687 Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284 G + L C G ++ W KD ++I E K+ F D+++ L I +++ D Sbjct: 4688 K--GSFIDLECIVAGSHPISIQWFKDDQEISASEK-YKFSFHDNTAFLEISQLEGTDSGT 4744 Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344 Y C A NKAG + HL V P + +V L G +I W Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKD 4804 Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404 + + S V +SL L + + TD+G YIC SN +G + L V+ Sbjct: 4805 NKELHS-----GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859 Query: 405 AP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461 P K PV V G C++ P +SW+ DG + + I + Sbjct: 4860 PPQFIKKPSPVLVLR-NGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFID--GL 4916 Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD- 520 + +++ + G Y C A N G S L + P+ I +++P + Sbjct: 4917 ATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPT--FIRELKPVEVVKYSDVEL 4974 Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580 E E TG P ++ W E+ SK Y + + I P T + N Sbjct: 4975 ECEVTGTPP---FEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSN 5031 Query: 581 GKGLGEISAASEFKTQP 597 G S K P Sbjct: 5032 EGGSCSCSTRVALKEPP 5048 Score = 102 bits (255), Expect = 1e-21 Identities = 102/449 (22%), Positives = 181/449 (40%), Gaps = 34/449 (7%) Query: 52 ISWFSPNGEKLTPNQQ-RISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110 + W E + ++ RI+ V N +TL A +AG Y C + DG E Sbjct: 5641 VQWLKEKEEVIRESENIRITFVEN---VATLQFAKAEPANAGKYICQIKN-DGGMRENMA 5696 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 + + + + P GE + C V + ++ W G+ + + +F + Sbjct: 5697 TLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756 Query: 171 N-NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV-----PPTIQARQNIVNAT 224 + L+I +++ D GTY + + + +V+V PP+ R + N Sbjct: 5757 KISSLRILSVERQDAGTYTFQ----VQNNVGKSSCTAVVDVSDRAVPPSFTRR--LKNTG 5810 Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDE 282 LG S L C G +++W + +I KY FSD+ L + +D +D Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVS---GAKYQTTFSDNVCTLQLNSLDSSDM 5867 Query: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSIT 340 Y C+A N AG + L V P ++V+ +E+ + VT T G P + Sbjct: 5868 GNYTCVAANVAGSDECRAVLTVQEPP--SFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925 Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400 W R + ++ + V+ L L +I + +GEY C SN GQ S + L Sbjct: 5926 WFRGARELVKGDR-----CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL 5980 Query: 401 EVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459 V+ ++ ++ E G + + +++W +DG + +S N I T Sbjct: 5981 FVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCN--IVTTE 6038 Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQE 488 LE+ ++ D G Y+C N G++ Sbjct: 6039 KTCILEILNSTKRDAGQYSCEIENEAGRD 6067 Score = 102 bits (253), Expect = 2e-21 Identities = 118/461 (25%), Positives = 182/461 (39%), Gaps = 31/461 (6%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE-SEATV 110 +SW E L +R S+ + S+ L I + I+D Y C++ E G + EA V Sbjct: 6958 VSWIKD--EYLISQSERCSITMTE-KSTILEILESTIEDYAQYSCLIENEAGQDICEALV 7014 Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 +V + F E GE A + C V + I W +K + + Sbjct: 7015 SV--LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISW-YKEHTKLRSAPAYKMQFK 7071 Query: 171 NNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV--NVPPTIQARQNIVNATAN 226 NN L I + +D G Y C+ G + + VI +PP + V+ T Sbjct: 7072 NNVASLVINKVDHSDVGEYSCKADNSV-GAVASSAVLVIKARKLPPFFARKLKDVHET-- 7128 Query: 227 LGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286 LG V C G +SW KDG ++ + + + F + + L I + D++ +Y Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTS-FVHNVATLQILQTDQSHIGQYN 7187 Query: 287 CIAENKAGEQDATIHLKVF---AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343 C A N G ++ L + P + L E T C +G ITW Sbjct: 7188 CSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAK 7247 Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403 R I G+ + ++LT+ + DAG+Y C ASN G+DS S L VQ Sbjct: 7248 DNREIRP-----GGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ 7302 Query: 404 YAP----KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459 P KL+ V E + C++ P + W++D + S S ++ Sbjct: 7303 EPPRFIKKLEPSRIVKQDEFTRYE--CKIGGSPEIKVLWYKDETEIQES--SKFRMSFVD 7358 Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 S + LE+ S D G+Y C A N G S L + P Sbjct: 7359 SVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399 Score = 99.8 bits (247), Expect = 1e-20 Identities = 152/620 (24%), Positives = 234/620 (37%), Gaps = 89/620 (14%) Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89 E+ V E + + + + D D W+ E Q+R V + + I Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQS 3213 Query: 90 DAGIYKCVVTGEDGSESEATVNV----KIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSL 145 DAG Y V G + S VN ++ Q+L P + G+ A C V+S Sbjct: 3214 DAGEYT-FVAGRNRSSVTLYVNAPEPPQVLQELQ------PVTVQSGKPARF-CAVISGR 3265 Query: 146 P-PTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGR---------- 192 P P I W + + + +F+ Y L I + D Y CE + Sbjct: 3266 PQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE-DAAVYTCEAKNDYGVATTSA 3324 Query: 193 --ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 + E+ D ++ V P I Q+ V + GQ C G + +SW Sbjct: 3325 SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSE---GQPARFQCRVSG-TDLKVSWYSK 3380 Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310 ++I+ F +D+ QL I + DE Y +A N G+ +T +L + A I Sbjct: 3381 DKKIKPSRFFRMTQF-EDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESI 3439 Query: 311 TY--VENQTAMELEEQVTL-----------------TCEASGDPIPSITWRTSTRNISSE 351 + +E + ME++ + TCE P W + R I Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499 Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAPK-L 408 +K +RS +SSL + Q D GEY C ASN G S + L V Y P L Sbjct: 3500 DKCS-----IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFL 3554 Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVT 467 P ++ T+ G C V P W +DG L PS N+ +I + + LE++ Sbjct: 3555 SRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW---RISDAENKHILELS 3611 Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST------AQVQFDE 521 + D G Y+C A N+ G + + L+ D P I ++EP S + Q DE Sbjct: 3612 NLTIQDRGVYSCKASNKFGADICQAELIIIDKPH--FIKELEPVQSAINKKVHLECQVDE 3669 Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWY----DAKEASMEGIVTIVGLKPETTYAVRLA 577 K W G+++ K Y + K A++E + + LK TY Sbjct: 3670 DR--------KVTVTWSKDGQKLPPGKDYKICFEDKIATLE--IPLAKLKDSGTYV--CT 3717 Query: 578 ALNGKGLGEISAASEFKTQP 597 A N G SA + P Sbjct: 3718 ASNEAGSSSCSATVTVREPP 3737 Score = 98.2 bits (243), Expect = 3e-20 Identities = 131/599 (21%), Positives = 224/599 (37%), Gaps = 68/599 (11%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C V ISW+ E+L + + +D TL + A +DA +Y C Sbjct: 3259 CAVISGRPQPKISWYKE--EQLLSTGFKCKFL-HDGQEYTLLLIEAFPEDAAVYTCEAKN 3315 Query: 101 EDG-SESEATVNVKIFQKLM-FKNAP-------TPQE---FREGEDAVIVCDVVSSLPPT 148 + G + + A+++V++ + + + P TP + EG+ A C V S Sbjct: 3316 DYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV-SGTDLK 3374 Query: 149 IIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTY-----RCEGRILARGEINFK 202 + W K + + + R + Y L+I DEGTY G++ + ++ + Sbjct: 3375 VSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 3434 Query: 203 ------------DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 +I++ + P I ++ I LG C+ + P W K Sbjct: 3435 APESILHERIEQEIEMEMKAAPVI--KRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 3492 Query: 251 GEQIEQEED----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306 G +I + + KYI S L I + D EY C A N+ G T L V Sbjct: 3493 GREIYESDKCSIRSSKYI-----SSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE 3547 Query: 307 KPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364 T++ ++ + + C +G P+ W+ +S + Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHI 3607 Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVN 423 +S+LT++ D G Y C ASN G D Q+ + + ++ V + +V+ Sbjct: 3608 LELSNLTIQ-----DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVH 3662 Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483 + C+V T++W +DGQ LP + KI + LE+ D G Y CTA N Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720 Query: 484 RIGQESLEFILVQADTPS-----SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538 G S + + PS PS + S+ + G P++ + W Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLK------GSPVI--QVTWF 3772 Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 +E+ S + E I+ I +K E + + A+N G S K P Sbjct: 3773 KNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP 3831 Score = 94.7 bits (234), Expect = 3e-19 Identities = 152/686 (22%), Positives = 268/686 (39%), Gaps = 74/686 (10%) Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98 F C+V + + WF N E + + + I + D TL I +A++DD Y + Sbjct: 12659 FNCEV--NTEGAKAKWFR-NEEAIFDSSKYI--ILQKDLVYTLRIRDAHLDDQANYNVSL 12713 Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQ-EFREGEDAVIVCDVVSSLPPTIIWKHKGRD 157 T G ++ N+ + ++ + P E E + C V + L T+ W G + Sbjct: 12714 TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE 12772 Query: 158 VILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA 216 V V + V + L I+ DEG Y I+ G+ K + ++ + + Sbjct: 12773 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEY-----IVTAGQD--KSVAELLIIEAPTEF 12825 Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS--QLTI 274 +++ + T C + + W ++G +I++ +KY F D S +L I Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKE---GKKYKFEKDGSIHRLII 12881 Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE---QVTLTCEA 331 K +DE EY C G +D ++F + + LE V E Sbjct: 12882 KDCRLDDECEYAC------GVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAEL 12935 Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391 + D + + W + + +K H ++ S ++ L + I+ D GEY I Sbjct: 12936 NKDKV-EVQWLRNNMVVVQGDK----HQMM-SEGKIHRLQICDIKPRDQGEY-----RFI 12984 Query: 392 GQDSQSMY-LEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 449 +D ++ LE+ APK++ + G + + AYP A WF++ + L + Sbjct: 12985 AKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKT 13044 Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP-SIDQV 508 I T + + + D G Y N+ G+ L D P +++ Sbjct: 13045 -----IDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVT 13099 Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL-K 567 E + + ++EP GG I+ Y E R ++ W A + + T+ GL K Sbjct: 13100 ETFDGEVSLAWEEPLTDGGSKIIGYVVERR----DIKRKTWVLATDRAESCEFTVTGLQK 13155 Query: 568 PETTYAVRLAALNGKGLGE-------ISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV 620 Y R++A N G GE + A S++ V G P + D N V Sbjct: 13156 GGVEYLFRVSARNRVGTGEPVETDNPVEARSKY---DVPGPPLNVTI-----TDVNRFGV 13207 Query: 621 NLI---KQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 676 +L + DGG+ I +Y++ R +S W + + + + + EY V A Sbjct: 13208 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 13267 Query: 677 ENQQGKSK-AAHFVFRTSAQPTAIPA 701 +N+ G K +A F A P P+ Sbjct: 13268 QNRIGVGKPSAATPFVKVADPIERPS 13293 Score = 84.7 bits (208), Expect = 3e-16 Identities = 70/266 (26%), Positives = 112/266 (42%), Gaps = 41/266 (15%) Query: 174 LQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVN-----VPPTIQARQN---- 219 L ++ I K D+GTYRC+ G + E+ K ++ + + I+ R + Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685 Query: 220 ----------IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269 + N TA +G++V PEP ++W K G++I+ ++D+KY F D Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745 Query: 270 S--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT----------YVENQT 317 QLTI V +D+AEY +A NK GE L V P T + N Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805 Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 E + V SG P P++ W + +S ++ +L ++ Sbjct: 31806 CQE-GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI----EIIHEGLDYYALHIRDTLP 31860 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQ 403 D G Y TA+NT G S +L+V+ Sbjct: 31861 EDTGYYRVTATNTAGSTSCQAHLQVE 31886 Score = 83.2 bits (204), Expect = 9e-16 Identities = 83/299 (27%), Positives = 122/299 (40%), Gaps = 23/299 (7%) Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 452 Q++ ++L+V KL + V G ++ + V P I+W + +L Sbjct: 13685 QEAPEIFLDV----KLLAGLTVKA--GTKIELPATVTGKPEPKITWTKADMILKQDK--R 13736 Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS-IDQVEPY 511 I I N P S + + +D G Y AVN G+ + + D P P+ D + Sbjct: 13737 ITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVT 13796 Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETT 571 + + + ++ P GG I Y E RA EVWH K+ + + I P Sbjct: 13797 NESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLI----PNKE 13852 Query: 572 YAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP--KLEGQMGEDGNSIKVNLI---KQD 626 Y R+AA N G+GE AS T Q +P P +LE D V L D Sbjct: 13853 YIFRVAAENMYGVGEPVQASPI-TAKYQFDPPGPPTRLE---PSDITKDAVTLTWCEPDD 13908 Query: 627 DGGSPIRHYLV-RYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 DGGSPI Y V R + +W ++P +K L +Y V+AEN G K Sbjct: 13909 DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK 13967 Score = 82.0 bits (201), Expect = 2e-15 Identities = 83/346 (23%), Positives = 143/346 (41%), Gaps = 22/346 (6%) Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400 W+TS +++ E T+ G + +KS+ A + ++ I ++ + Sbjct: 26130 WKTSIQSLRGTEYTISGLTTGAEYV----FRVKSVNKVGASDPSDSSDPQIAKEREE--- 26182 Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460 E + + + G +T P + W + L + Y + T S Sbjct: 26183 EPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAY----VDTTDS 26238 Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQF 519 + L + + ND G Y T N + SL ++ DTP P+ V+ + +A + + Sbjct: 26239 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 26298 Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579 D PE GG P+ Y E R ++ W S + S + + L+ Y R++ Sbjct: 26299 DVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK----VTNLQEGAIYYFRVSGE 26354 Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVR 638 N G+G + E + +PS P+ G +S+ + +K + DGGS I HY+V Sbjct: 26355 NEFGVGIPAETKE--GVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV- 26411 Query: 639 YRALSSEWKPEIRLP-SGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 AL K ++ + S H ++ L N+EY V AENQ G S Sbjct: 26412 -EALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLS 26456 Score = 80.9 bits (198), Expect = 5e-15 Identities = 98/409 (23%), Positives = 161/409 (39%), Gaps = 48/409 (11%) Query: 315 NQTAMELEEQVTLTCEASGDPIPS--ITWRTSTRNISS---EEKTLDG---------HMV 360 N+ + L + T + S P+P +T TRN ++ E+ DG M Sbjct: 25276 NEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQ 25335 Query: 361 VRSHARVSSLT-LKSIQYTDAG-----EYI--CTASNTIGQDSQSMY------LEVQYAP 406 + + S+ T +K+++ T +G EY+ A N G+ +++ P Sbjct: 25336 TKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP 25395 Query: 407 KLQGPVAVYTWEGN-QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465 ++ P + + Q+ I P AT++W +DGQ L + N+ T ++ L Sbjct: 25396 SVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS--LS 25453 Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS---IDQVEPYSSTAQVQFDEP 522 + S+ D G Y N G ++ ++ D P P ID+V S T + ++ P Sbjct: 25454 IKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSIT--ISWNPP 25511 Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582 E GG I Y E + WH +A + IV L + Y R+ A N Sbjct: 25512 EYDGGCQISNYIVEKKETTSTTWHI----VSQAVARTSIKIVRLTTGSEYQFRVCAENRY 25567 Query: 583 GLGEISAAS----EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVR 638 G S +S E+ P G P PK+ + + +DGGS + Y + Sbjct: 25568 GKSSYSESSAVVAEYPFSP-PGPPGTPKVVH--ATKSTMLVTWQVPVNDGGSRVIGYHLE 25624 Query: 639 YRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 Y+ SS W ++ + + LD YE V AEN G K + Sbjct: 25625 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCS 25673 Score = 80.5 bits (197), Expect = 6e-15 Identities = 127/573 (22%), Positives = 210/573 (36%), Gaps = 51/573 (8%) Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 I+ V PPT+ W R + + + +S++ + I+ +++ +G Y +LA+ Sbjct: 16544 IIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMV-IKNCQRSHQGVYS----LLAK 16598 Query: 197 GEINFKDIQVIVNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254 E + +IV+V P + + N +T + P ++ I Sbjct: 16599 NEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYV-----I 16653 Query: 255 EQEEDDEK----YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD--ATIHLKVFAKP 308 E+ E D + ++ T++ + + + AEN G T V +P Sbjct: 16654 EKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREP 16713 Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG---HMVVRSHA 365 IT E +E++E T + +P P + N E + + H V + Sbjct: 16714 -ITVPERPEDLEVKEVTKNTVTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNL 16771 Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE-VQYAPKLQGPVAVYTWEGNQVNI 424 T+K ++ D EY +A N +GQ S + + +L P + Sbjct: 16772 LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIR 16831 Query: 425 TCEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 E FA P +SWF+D + + ++IK TP+ LE +D G Y Sbjct: 16832 VGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIK--TTPATLALEKIKAKRSDSGKY 16889 Query: 478 NCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPILKY 533 N G + D P P S D+V + + P GG I Y Sbjct: 16890 CVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVT--KDYMVISWKPPLDDGGSKITNY 16947 Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593 E + VG++V W AS + + L Y R+ A N G+ + + Sbjct: 16948 IIEKKEVGKDV----WMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSM 17003 Query: 594 KTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR-ALSSEWKPEIRL 652 K + P AP +S V K DGG PI +Y++ R +S W R+ Sbjct: 17004 KAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRW---ARV 17060 Query: 653 PSGSDHVMLK----SLDWNAEYEVYVVAENQQG 681 H K L +YE V AEN+ G Sbjct: 17061 TKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIG 17093 Score = 80.5 bits (197), Expect = 6e-15 Identities = 114/514 (22%), Positives = 202/514 (39%), Gaps = 55/514 (10%) Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTI 274 R+ + + T LG++ L C G P P + W + G+++ Q KY S D + LT+ Sbjct: 30536 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ---SRKYKMSSDGRTHTLTV 30592 Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI---TYVENQTAMELEEQVTLTCEA 331 ++ DE Y CIA N+ GE + + L + A P+ ++ + + + L Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652 Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ-YTDAGEYICTASNT 390 G P+P++TW + + + E ++ + + + L +K++Q T AG+Y SN Sbjct: 30653 IGRPVPAMTWFHGQKLLQNSE-----NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNV 30707 Query: 391 IGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWF---------- 439 G + +E+Q P K GP+ + N I+ + A SW Sbjct: 30708 FGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGG--SWITNYVVEKCEA 30765 Query: 440 ---RDGQLLPSS-NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 + QL+ S+ + + +I N + ++N FG + V+ + ++ Sbjct: 30766 KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFE 30823 Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555 + P P+I V + V + P + GG I Y E R + W S E Sbjct: 30824 KPGAPGKPTITAVT--KDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISV---TTEE 30878 Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDG 615 E + ++ L Y R+ N G E S SE P+ + P E+ Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE----PITPKSDVPIQAPHFKEEL 30934 Query: 616 NSIKVN-------LIKQDDGGSPI-RHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWN 667 ++ V + K PI + Y ++ K I+ G H ++ + + Sbjct: 30935 RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTD 30994 Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 701 + VY V QG S V T++ +PA Sbjct: 30995 DDATVYQVRATNQGGS-----VSGTASLEVEVPA 31023 Score = 80.5 bits (197), Expect = 6e-15 Identities = 84/399 (21%), Positives = 168/399 (42%), Gaps = 33/399 (8%) Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-RISVVWNDDSSS 79 ++ +Q I+ G+ +AG D+ W NG +LT +++ R V +D Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAGAT---DVKWVL-NGVELTNSEEYRYGVSGSDQ--- 33092 Query: 80 TLTIYNANIDDAGIYKCVVTGEDG---SESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136 TLTI A+ D GI C+ ++G + + T++ ++ F + P Q EG++ + Sbjct: 33093 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVL 33152 Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA 195 C++ P I W + + +V N Y L+IR +D G Y + + Sbjct: 33153 FTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNF- 33211 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATAN--------LGQSVTLVCDAEGFPEPTMSW 247 RG+ + ++ +P + + +V T+ QSV + + E + S Sbjct: 33212 RGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQ---EASFSS 33266 Query: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307 E + + S + V+ + + ++ I+ E + LK + Sbjct: 33267 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMS-SSSFMGISNMTQLESSTSKMLKAGIR 33325 Query: 308 ---PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364 PKI + + +++ + +T+ C +G+P P +TW R I S+E+ G + + Sbjct: 33326 GIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ---GRFHIENT 33382 Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403 +++L + +Q D G Y + N G DS ++ + ++ Sbjct: 33383 DDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421 Score = 79.3 bits (194), Expect = 1e-14 Identities = 80/308 (25%), Positives = 119/308 (38%), Gaps = 23/308 (7%) Query: 406 PKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464 P L+ P Y+ + G + I V P ISW +DG+ P + + + T +++ L Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE--PLKQTTRVNVEETATSTVL 24369 Query: 465 EVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 522 + +++DFG Y TA N G E+L I+++ P + E + + ++ P Sbjct: 24370 HIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPP 24429 Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582 TGG I Y E R WH + I LK T Y R+ A N Sbjct: 24430 AYTGGCQISNYIVEKRDTTTTTWHM----VSATVARTTIKITKLKTGTEYQFRIFAENRY 24485 Query: 583 GLGEISAASEFKTQPVQ------GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYL 636 G SA + K VQ G P P + + +D ++ + D G I ++L Sbjct: 24486 GK---SAPLDSKAVIVQYPFKEPGPPGTPFVT-SISKDQMLVQWHEPVNDGGTKIIGYHL 24541 Query: 637 VRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRT 692 + S W + P LD EYE V AEN G K + FV R Sbjct: 24542 EQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARD 24601 Query: 693 SAQPTAIP 700 P P Sbjct: 24602 PCDPPGRP 24609 Score = 77.4 bits (189), Expect = 5e-14 Identities = 102/434 (23%), Positives = 169/434 (38%), Gaps = 33/434 (7%) Query: 271 QLTIKKVDKNDEAEYICIAENKAG-----EQDATIHLKVFA--KPKITYVENQTAMELEE 323 Q TI + + E E+ AEN+ G +I K+ + P I +L E Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548 Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383 L+C+ G P+P I W + + K + S R +LT+ + + D G Y Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRFGKELIQSRK-----YKMSSDGRTHTLTVMTEEQEDEGVY 30603 Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAV----YTWEGNQVNITCEVFAYPSATISWF 439 C A+N +G+ S L +Q P+ + Y G+ + + P ++WF Sbjct: 30604 TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF 30663 Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEV-TPDSENDFGNYNCTAVNRIGQ-ESLEFILVQ- 496 +LL N NI I NT ++L + + G Y N G +++ + +Q Sbjct: 30664 HGQKLL--QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721 Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555 D P+ P + + ++A + + P GG I Y E E ++W A Sbjct: 30722 KPDKPTGPIVIEA-LLKNSAVISWKPPADDGGSWITNYVVEKCEAKE---GAEWQLVSSA 30777 Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQ-PVQGEPSAPKLEGQM 611 IV L Y R++A N G+ E+S+ K+ G P P + Sbjct: 30778 ISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVT 30837 Query: 612 GEDGNSIKVNLIKQDDGGSPIR-HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEY 670 + + + DGG+ IR +YL + ++W +K+L EY Sbjct: 30838 KD--SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEY 30895 Query: 671 EVYVVAENQQGKSK 684 E V EN G+S+ Sbjct: 30896 EFRVKCENLGGESE 30909 Score = 77.0 bits (188), Expect = 7e-14 Identities = 90/356 (25%), Positives = 142/356 (39%), Gaps = 29/356 (8%) Query: 365 ARVSSLTLKSIQYTDAGEYI--CTASNTIGQ-DSQSMYL-----EVQYAPKLQGPVAVYT 416 ARV SL T EY+ A N G+ D +S+ + ++ P ++ + Y+ Sbjct: 23181 ARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYS 23240 Query: 417 WE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 475 + G + I + P TI+W +DG LP + I + ++ + L + ++D G Sbjct: 23241 VQVGQDLKIEVPISGRPKPTITWTKDG--LPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298 Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPIL 531 Y T N +GQ++ +V D P P D V S T + ++ P TGG I Sbjct: 23299 QYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT--LSWNPPLYTGGCQIT 23356 Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590 Y + R VW D A++ + + LK T Y R+ A N G + Sbjct: 23357 NYIVQKRDTTTTVW-----DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALES 23411 Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSP-IRHYLVRYRALSSEWKP 648 Q EP P +S+ + + ++GGSP I ++L R S W Sbjct: 23412 DPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTK 23471 Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRTSAQPTAIP 700 + ++L+ EYE V AEN G KA+ +V R P P Sbjct: 23472 VNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP 23527 Score = 77.0 bits (188), Expect = 7e-14 Identities = 149/666 (22%), Positives = 258/666 (38%), Gaps = 110/666 (16%) Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135 DS STLT+ N N +DAG Y V GS+S T VK+ P P F++ Sbjct: 28408 DSFSTLTVENCNRNDAGKYTLTVENNSGSKS-ITFTVKVLDT---PGPPGPITFKD---- 28459 Query: 136 VIVCDVVSSLPPTIIWKHKGRD--------VILKKDVRF----IVLSNNYLQIRGIKKTD 183 V+ T++W D V+ K++ ++ QI + Sbjct: 28460 ------VTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLA 28513 Query: 184 EGT---YRCEG-RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEG 239 EG +R GE ++ P R ++V+ + + L D +G Sbjct: 28514 EGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDG 28573 Query: 240 FPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAG-- 294 T G +E +++ + ++ + + QLT ++++ + E E+ A+N AG Sbjct: 28574 GSRIT------GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYS 28627 Query: 295 EQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA----------SGDPIPSITWRTS 344 E + +P+I + T + + +TC+A SG P P +TW+ Sbjct: 28628 EPREAFSSVIIKEPQIEPTADLTGITNQ---LITCKAGSPFTIDVPISGRPAPKVTWKLE 28684 Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404 + ++ + + + ++LT+K D+G Y T NT G + S+ + V Sbjct: 28685 EMRLKETDR-----VSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 28739 Query: 405 AP-KLQGPV---------AVYTW----EGNQVNITCEVF-AYPSATISWFRDGQLLPSSN 449 P + GP+ V +W +G IT + S T +W L +S+ Sbjct: 28740 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW-----QLVNSS 28794 Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQAD----TPSSPS 504 +I T Y+E ++ ++ NR G + LE + A+ PS+P+ Sbjct: 28795 VKRTQIKVTHLTKYMEY---------SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPT 28845 Query: 505 IDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 563 +V S+ A ++++EP GG I+ Y E + +W + K +E + Sbjct: 28846 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVK---ENKVPCLECNYKV 28902 Query: 564 VGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLEGQMGEDGNSIKVNL 622 GL Y R ALN G+ + S AS Q P P++ D V+L Sbjct: 28903 TGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEV-----TDVTRSTVSL 28957 Query: 623 I---KQDDGGSPIRHYLVRYRALS----SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675 I DGGS + Y++ + +S W + + +L YE V+ Sbjct: 28958 IWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVL 29017 Query: 676 AENQQG 681 A+N G Sbjct: 29018 AKNAAG 29023 Score = 76.3 bits (186), Expect = 1e-13 Identities = 111/520 (21%), Positives = 189/520 (36%), Gaps = 72/520 (13%) Query: 50 KDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE---- 105 K+++W+ +G+KL N ++ D + L I N D G Y C ++GE G+ Sbjct: 32747 KEVTWYK-DGKKLKENGH-FQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 32804 Query: 106 ---------------------------SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 +E+TV K K + P +D + Sbjct: 32805 QFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVS 32864 Query: 139 CDVVSSLP--------PTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRC 189 D V+ PT IW G+ + + + L+I +D G Y C Sbjct: 32865 SDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTC 32924 Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE------GFPEP 243 + A G ++ ++ + +A++ T+ + V E E Sbjct: 32925 TVKNSA-GSVS-SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEI 32982 Query: 244 TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303 MS K E++ +E+ K + S++ + ++K+ E I + E +K Sbjct: 32983 KMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIK 33042 Query: 304 VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363 F+ T M + E L +A+ + W + +++ E+ G Sbjct: 33043 AFS----------TQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYG-----V 33087 Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPK-LQGPVAVYTWE 418 +LT+K + D G C + G Q ++ E+ AP + P + E Sbjct: 33088 SGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINE 33147 Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G V TCE+ PS I WF++ LP S SN+ I + + LE+ S +D G Y Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNN--LPISISSNVSISRSRNVYSLEIRNASVSDSGKYT 33205 Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518 A N GQ S L+ PS + V S +Q Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQ 33245 Score = 75.5 bits (184), Expect = 2e-13 Identities = 79/284 (27%), Positives = 106/284 (37%), Gaps = 39/284 (13%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G V + VF P T+SW +DG LL + IK+ + LE+ + D G+Y Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPA--EGIKMAMQRNLCTLELFSVNRKDSGDYT 19367 Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 TA N G +S L D P P S+ + YS A + ++ P GG I Y + Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPET-----TYAVRLAALNGKGLGEISAASE 592 R W A + V I E Y R+ A N G+G+ Sbjct: 19428 RETSRPNW---------AQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGD------ 19472 Query: 593 FKTQPVQGEPSAPKLE-GQMGEDGNSIKVNLIKQ----------DDGGSPIRHYLVRYRA 641 PV EP+ K G + N+ K DDGGSPI YL+ R Sbjct: 19473 ----PVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRE 19528 Query: 642 LSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 + W R P + L EYE V A N+ G K Sbjct: 19529 TQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGK 19572 Score = 75.5 bits (184), Expect = 2e-13 Identities = 78/292 (26%), Positives = 129/292 (44%), Gaps = 20/292 (6%) Query: 401 EVQYAPKLQGPVAVYTW----EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456 ++ AP++ VA+ T G V + P T++W +D + L S + I Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSD--ARYSIE 27321 Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA-DTPSSPSIDQVEPYS-ST 514 NT S+S L + + ND G Y T N +G+ + V+ DTP++ QV+ S T Sbjct: 27322 NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGT 27381 Query: 515 AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAV 574 + +D P GG PI+ Y E R + W + S + ++ L +T + Sbjct: 27382 VTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFK----LIDLSEKTPFFF 27437 Query: 575 RLAALNGKGLGEISAASEFKTQPVQ-GEPSAPKLEGQMGED-GNSIKVNLIKQD-DGGSP 631 R+ A N G+GE T+PV+ E AP + M + S+ ++ K D DGGS Sbjct: 27438 RVLAENEIGIGEPCET----TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSV 27493 Query: 632 IRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 I Y+V + + + S + + + L + E V A+N++G S Sbjct: 27494 ITEYVVERKGKGEQTWSHAGI-SKTCEIEVSQLKEQSVLEFRVFAKNEKGLS 27544 Score = 75.1 bits (183), Expect = 3e-13 Identities = 84/331 (25%), Positives = 128/331 (38%), Gaps = 16/331 (4%) Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419 VVR+ T + + AG S + Q+M E+ Q V G Sbjct: 21023 VVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--G 21080 Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479 + + + V P T++W + Q+L + N + T +++ L + +D G Y Sbjct: 21081 DNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE--TTATSTILNINECVRSDSGPYPL 21138 Query: 480 TAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 TA N +G+ + D P P+ I E S +D PE GGVPI Y E Sbjct: 21139 TARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 21198 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596 R W + + GL+ Y R+ A N G+G I++A Sbjct: 21199 RQTDSTTWVELATTVIRTTYKATRLTTGLE----YQFRVKAQNRYGVGPGITSACIVANY 21254 Query: 597 P--VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLP 653 P V G P P++ + +D +I + DGGSPI Y V + + W+ + Sbjct: 21255 PFKVPGPPGTPQVTA-VTKDSMTISWH-EPLSDGGSPILGYHVERKERNGILWQTVSKAL 21312 Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 + L YE V+AEN GKSK Sbjct: 21313 VPGNIFKSSGLTDGIAYEFRVIAENMAGKSK 21343 Score = 73.9 bits (180), Expect = 6e-13 Identities = 117/490 (23%), Positives = 188/490 (38%), Gaps = 69/490 (14%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST-LTIYNANIDDAG 92 G S F CQV G+ K ++ +G LT R V +N + L I DDAG Sbjct: 1096 GGSVVFGCQVGGNPKPH--VYWKKSGVPLTTGY-RYKVSYNKQTGECKLVISMTFADDAG 1152 Query: 93 IYKCVVTGEDGS---------ESEATVNVKIFQKLMFKNAPTP--QEFREGEDA----VI 137 Y VV + G E++ + +K Q+++++ T QE + GE A Sbjct: 1153 EYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYS 1212 Query: 138 VCDVVSSLPPTIIWKHKGRDVILKK----DVRFIVLSNNY-----LQIRGIKKTDEGTYR 188 + +I K +D ++ + D F + S ++ R IK T E Sbjct: 1213 EYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLE 1272 Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248 +G E DI V +R I N G VT C G+P P ++W Sbjct: 1273 EDGE-----EKMAVDISESEAVESGFDSR--IKNYRILEGMGVTFHCKMSGYPLPKIAWY 1325 Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 KDG++I+ E + D + L I V DE Y A N G +A K++ +P Sbjct: 1326 KDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG--NAICSGKLYVEP 1383 Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368 P+ + T+ + + S ++L V RS R+S Sbjct: 1384 ------------------------AAPLGAPTYIPTLEPV-SRIRSLSPRSVSRSPIRMS 1418 Query: 369 SLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNI 424 + + + A + A + G +++ LE Y P + PV+ EG Sbjct: 1419 PARMSPARMSPA--RMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARF 1476 Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484 +V P WF DGQ + ++Y++ + L + P + +D G + A NR Sbjct: 1477 DLKVVGRPMPETFWFHDGQQI-VNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNR 1535 Query: 485 IGQESLEFIL 494 G+ S+ IL Sbjct: 1536 AGRSSISVIL 1545 Score = 73.9 bits (180), Expect = 6e-13 Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 13/282 (4%) Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 + P SW + G+ + S+ + I +TP++S L + + D G Y TA N G Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDITQIT--STPTSSMLTIKYATRKDAGEYTITATNPFGT 20460 Query: 488 ESLEFILVQADTPSSPSIDQVEPYSS-TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546 + + D P P ++ S+ A + + P GG PI Y E R +W Sbjct: 20461 KVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520 Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK 606 D + I G Y R++A+N G GE + K G P P+ Sbjct: 20521 VVSEDIQSCRHVATKLIQG----NEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPE 20576 Query: 607 LEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSL 664 N+ V+ + DDGGS I Y V R S W I+ P + L Sbjct: 20577 KPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGL 20636 Query: 665 DWNAEYEVYVVAENQQG---KSKAAHFV-FRTSAQPTAIPAN 702 + YE V AEN+ G S+A+ V + +A P P+N Sbjct: 20637 QEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678 Score = 73.2 bits (178), Expect = 1e-12 Identities = 83/348 (23%), Positives = 134/348 (38%), Gaps = 21/348 (6%) Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT 311 E+I + K + + +K + E+E+ I+E + D I F + Sbjct: 30877 EEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEEL-- 30934 Query: 312 YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371 + + TL C+ +G P P + W + I ++ + + L Sbjct: 30935 ---RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLK---YRIQEFKGGYHQLI 30988 Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK------LQGPVAVYTWEGNQVNIT 425 + S+ DA Y A+N G S + LEV+ K L+G AV+ G V+I Sbjct: 30989 IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIK 31048 Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 P I+W + L+ ++ + + I S + D G Y A NR Sbjct: 31049 IPFSGKPDPVITWQKGQDLIDNNGHYQV-IVTRSFTSLVFPNGVERKDAGFYVVCAKNRF 31107 Query: 486 GQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEV 544 G + L AD P P +V S + + + EP + GG I Y E A E Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE- 31166 Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 +W +A E T++ L +T+Y R+ A N GL + S SE Sbjct: 31167 ---RWLRVGQA-RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSE 31210 Score = 72.0 bits (175), Expect = 2e-12 Identities = 102/442 (23%), Positives = 171/442 (38%), Gaps = 45/442 (10%) Query: 271 QLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKIT-YVENQTAMELEE--QV 325 Q T++ + + E E+ A N AG + AT+ +P + ++ + ME+EE V Sbjct: 16075 QFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNV 16134 Query: 326 TLTCEASGDPIPSITW-RTSTRNISSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEY 383 + + G P P++TW + + ++E L D H+ +L + + +D G Y Sbjct: 16135 NIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194 Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWF--R 440 TA N +G S+ M L V P GP+ + +Q+ T+SWF + Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQM------------TLSWFPPK 16242 Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---- 486 D +NY + + + + P + E + A N+ G Sbjct: 16243 DDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEP 16302 Query: 487 ----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542 E+ + P P++ V S T V ++EPE GG P+ Y E + Sbjct: 16303 LDSEPETARNLFSVPGAPDKPTVSSVTRNSMT--VNWEEPEYDGGSPVTGYWLEMKDTTS 16360 Query: 543 EVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGE 601 + W D +A G+ + GL + Y R+ A+N G+G S S+ T Sbjct: 16361 KRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIA 16420 Query: 602 PSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHV 659 P P +S + DGGS + Y+V Y+ EW+ + Sbjct: 16421 PPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 16480 Query: 660 MLKSLDWNAEYEVYVVAENQQG 681 ++ L A Y+ V A N G Sbjct: 16481 VVTGLKEGAFYKFRVRAVNIAG 16502 Score = 71.6 bits (174), Expect = 3e-12 Identities = 131/548 (23%), Positives = 215/548 (39%), Gaps = 70/548 (12%) Query: 190 EGRILARGEINFKDI-QVIVNVPPTIQARQNI--VNATANLGQSVTLVCDAEGFPEPTMS 246 + +LA E F+ + V V PTI+ + I +N G+ L +G + Sbjct: 18061 KANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLK 18120 Query: 247 WTK---DG----------EQIEQEEDDEK-YIFSDDSSQLTIKKVDKNDEAEYICIAENK 292 W + DG +++ +D E+ + S + + + +N E+ +N+ Sbjct: 18121 WRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 18180 Query: 293 AGEQDATIHLKVFAKPKITY------VENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346 GE D +V K + + ++ + + L G P P + W T+ Sbjct: 18181 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAW---TK 18237 Query: 347 NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP 406 + + + T + + + A S +L + +D G+Y+ TA+NT G S Y V Sbjct: 18238 DKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG--SFVAYATVNVLD 18295 Query: 407 KLQGPV------------AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454 K GPV W+ + + CE+ Y I + + + S YS Sbjct: 18296 K-PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNY----ILEKCETKRMVWSTYSATV 18350 Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFIL-VQADTPSSPSIDQVE 509 + TP + + +E F A N+IG ES I + D P P +V Sbjct: 18351 L--TPGTTVTRLIEGNEYIF---RVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT 18405 Query: 510 PYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA-KEASMEGIVTIVGLK 567 S V ++ PE GG I Y E +E ++W K A E + + L Sbjct: 18406 KVSKEEMTVVWNPPEYDGGKSITGYFLE----KKEKHSTRWVPVNKSAIPERRMKVQNLL 18461 Query: 568 PETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLIKQ- 625 P+ Y R+ A N G+GE S S EP P ++ + +SI + K Sbjct: 18462 PDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPV 18521 Query: 626 DDGGSPIRHYLVRYRALSSEWKPE---IRLPSGSDHV----MLKSLDWNAEYEVYVVAEN 678 DGG+PI Y+V R ++ P+ R + + V + SLD N EYE V A+N Sbjct: 18522 YDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQN 18581 Query: 679 QQGKSKAA 686 Q G + A Sbjct: 18582 QVGIGRPA 18589 Score = 71.2 bits (173), Expect = 4e-12 Identities = 73/258 (28%), Positives = 106/258 (41%), Gaps = 19/258 (7%) Query: 432 PSATISWFRDGQLLPSSNYS-NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490 P+ T W + P SN S I+ T S S L V + ND G Y T N G +S+ Sbjct: 28385 PTPTAVWSK-----PDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSI 28439 Query: 491 EFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549 F + DTP P I + +A + +D P GG I Y E R E W Sbjct: 28440 TFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKR----EASRRSW 28495 Query: 550 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG--EPSAPKL 607 E I + L Y R++A+N G+GE E P+ +P+ P+ Sbjct: 28496 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPE----PIVATEQPAPPRR 28551 Query: 608 EGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDW 666 + +S + +K D DGGS I YL+ R S++ E + + ++ Sbjct: 28552 LDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVE- 28610 Query: 667 NAEYEVYVVAENQQGKSK 684 EYE V A+N G S+ Sbjct: 28611 KTEYEFRVKAKNDAGYSE 28628 Score = 70.9 bits (172), Expect = 5e-12 Identities = 73/286 (25%), Positives = 116/286 (40%), Gaps = 20/286 (6%) Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 EG +++I A P T+SW +DG+ + +S+ +K N +++LEV D G Y Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMK--NDHISAHLEVPKSVRADAGIY 14457 Query: 478 NCTAVNRIGQESLEFILVQADTPSS-PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536 T N++G + + P I + S+ ++ ++ PE GG PIL Y E Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517 Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596 R G + + S T+ L P Y R+ A+N G GE Sbjct: 14518 RREAGRRTYIPVMSGENKLSW----TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIA 14573 Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD--DGGSPIRHYLVRYRALSSEWKPEIRLPS 654 +P P ++ ++ K DGGS I Y++ A K E R Sbjct: 14574 QDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIA-----KGEERWKR 14628 Query: 655 GSDHVM------LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 694 ++H++ K L+ EY+ V AEN G S+ + T A Sbjct: 14629 CNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 14674 Score = 70.1 bits (170), Expect = 8e-12 Identities = 135/629 (21%), Positives = 238/629 (37%), Gaps = 73/629 (11%) Query: 49 DKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEA 108 + ++ W G + ++ +I V S + L I N D+G Y + GS++ A Sbjct: 25136 EPEVKWEKAEG--ILTDRAQIEVT---SSFTMLVIDNVTRFDSGRYNLTLENNSGSKT-A 25189 Query: 109 TVNVKIFQKLMFKNAPTPQEFRE-GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-- 165 VNV++ +AP RE +D+V +S PP I K + I++K Sbjct: 25190 FVNVRVLDS---PSAPVNLTIREVKKDSV----TLSWEPPLIDGGAKITNYIVEKRETTR 25242 Query: 166 --FIVLSNNYLQIR-GIKKTDEGTYRCEGRILARGEINF-----KDIQVIVNVPPTIQAR 217 + ++NN + I+ EG R+LA E V V+ PP R Sbjct: 25243 KAYATITNNCTKTTFRIENLQEGC-SYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGR 25301 Query: 218 QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQL--TI 274 +V+ T N +++G + T G +E Q + EK+ L TI Sbjct: 25302 VTLVDVTRNTATIKWEKPESDGGSKIT------GYVVEMQTKGSEKWSTCTQVKTLEATI 25355 Query: 275 KKVDKNDEAEYICIAENKAGEQDA------TIHLKVFAKPKITYVENQTAMELEEQVTLT 328 + +E + A N+ G D I + KP + + ++ EQ+ + Sbjct: 25356 SGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKID 25415 Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388 G P ++ WR + + + + V S V+SL++K D G Y S Sbjct: 25416 VPFKGRPQATVNWRKDGQTLKETTR-----VNVSSSKTVTSLSIKEASKEDVGTYELCVS 25470 Query: 389 NTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNITCEVFAY-----PSA 434 N+ G + + + V P GP+ + +W + + C++ Y + Sbjct: 25471 NSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETT 25530 Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 + +W Q + ++IKI + S + +EN +G + + + + E+ Sbjct: 25531 STTWHIVSQAVAR---TSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV---VAEYPF 25584 Query: 495 VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554 P +P + V ST V + P GG ++ Y E++ +W K Sbjct: 25585 SPPGPPGTPKV--VHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKA---NKI 25639 Query: 555 ASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED 614 + + + GL Y R+ A N G+G+ S + E P + P Sbjct: 25640 LIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE--PVPARDPCDPPGQPEVTNIT 25697 Query: 615 GNSIKVNLIKQD-DGGSPIRHYLVRYRAL 642 S+ + K DGG+ I Y+V R L Sbjct: 25698 RKSVSLKWSKPHYDGGAKITGYIVERREL 25726 Score = 69.7 bits (169), Expect = 1e-11 Identities = 99/411 (24%), Positives = 162/411 (39%), Gaps = 49/411 (11%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G + L +G P P WTK+G+ I + S+ ++L IK+ D+ D Y Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKR---AMIATSETHTELVIKEADRGDSGTYDL 30207 Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347 + ENK G++ I ++V P + +E ++ + S P P+ Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPN----SPEGPLEYDDIQVRSVRVSWRP-PADDGGADILG 30262 Query: 348 ISSEEKTLD--GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405 E + + + S R +SL +K ++ + +A N G S+ + E Sbjct: 30263 YILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFG-ISKPLKSEEPVT 30321 Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIKIYNTP-- 459 PK P + +++T S ++SW R DG + Y K +T Sbjct: 30322 PKTPLNPPEPPSNPPEVLDVT-----KSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKW 30376 Query: 460 --------SASYLEVT---PDSENDFGNYNCTAVNRIG----QESLEFILVQ--ADTPSS 502 + + VT PD+E F A N +G + E ++ + D PS Sbjct: 30377 VRHNKTQITTTMYTVTGLVPDAEYQF---RIIAQNDVGLSETSPASEPVVCKDPFDKPSQ 30433 Query: 503 P-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561 P ++ + + +Q+++PE GG IL Y E+R G+ W KE + Sbjct: 30434 PGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKK---SNKERIKDKQF 30490 Query: 562 TIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQPVQGEPSAPKLEGQM 611 TI GL T Y R+ A N GL A KT+ GE AP + +M Sbjct: 30491 TIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGE--APGIRKEM 30539 Score = 69.3 bits (168), Expect = 1e-11 Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD--KNDEAEY 285 GQ+ + + + P + W +G ++++ K +++ S LT++ +D +D Y Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNTSGVLTLEILDCHTDDSGTY 32444 Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345 + N GE L V TY + E+ V P +T RT Sbjct: 32445 RAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSV----------FPELT-RTEA 32493 Query: 346 RNISSEEKTLDGHMV-----VRSHARVSSLTLKSIQYTDAGEYICTA--SNTIGQDSQSM 398 +SS +KT + V+S + +L S +++ + E A ++ + S + Sbjct: 32494 YAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTR 32553 Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 457 ++ A + L P ++ +EG +C+ P T++W R GQ+L +S + ++ Sbjct: 32554 KIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS--ARHQVTT 32611 Query: 458 TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-------VQADTPSSPSIDQVEP 510 T S E++ +D GNY+ N G++ EF L + S P + EP Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 32671 Score = 68.6 bits (166), Expect = 2e-11 Identities = 89/328 (27%), Positives = 137/328 (41%), Gaps = 46/328 (14%) Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392 G P+P+ W T I ++E H V + S LT+K+ D GEY T SN G Sbjct: 17536 GVPVPTAKWTTDGSEIKTDE-----HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAG 17590 Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDGQLLPSSNY 450 + +++L V P GP T N +++T E TISW +D P NY Sbjct: 17591 SKTVAVHLTVLDVP---GPP---TGPINILDVTPE-----HMTISWQPPKDDGGSPVINY 17639 Query: 451 SNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ 496 K + + S + L++ + + A N+IG +S + Sbjct: 17640 IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKH 17699 Query: 497 ADTPSSPSIDQV--EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554 +P SP V + + A V + P++ GG PI Y E R V KW + Sbjct: 17700 KFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREV-----TGKWVRVNK 17754 Query: 555 ASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASE--FKTQPVQ--GEPSAPKLEG 609 + + + GL TY R+ A N GL + S +S+ +P++ G P PKL+ Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKD 17814 Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLV 637 + E + + + DGGSPI Y+V Sbjct: 17815 KSRETADLVWTKPL--SDGGSPILGYVV 17840 Score = 67.8 bits (164), Expect = 4e-11 Identities = 96/395 (24%), Positives = 157/395 (39%), Gaps = 58/395 (14%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 E L + G PIP + W + + E+T M ++S + ++L +K TD G+ Sbjct: 24723 ETFVLEADIRGKPIPDVVWSKDGKEL---EETA-ARMEIKSTIQKTTLVVKDCIRTDGGQ 24778 Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAV---------YTW----EGNQVNITCEV 428 YI SN G S + ++V P +GP+ V W + NI+ + Sbjct: 24779 YILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYI 24838 Query: 429 F-AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG- 486 ++ +SW + + + NY K+ P Y+ + AVN+ G Sbjct: 24839 IEKRETSRLSWTQVSTEVQALNYKVTKL--LPGNEYI------------FRVMAVNKYGI 24884 Query: 487 QESLEFILVQA----DTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVG 541 E LE V A P PS +V + + V + P GG I Y E R Sbjct: 24885 GEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKR--- 24941 Query: 542 EEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF----KTQ 596 + +W + ++ + + + GL +Y R+AA N G+GE S S F Sbjct: 24942 -DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDAL 25000 Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVRYRALSSEWKPEIRLP 653 G PS PK+ D + V+L DGG+P++ Y+V + +++ P Sbjct: 25001 YPPGPPSNPKV-----TDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP 25055 Query: 654 SG--SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 +G + L N EY + A N +G + A Sbjct: 25056 TGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPA 25090 Score = 67.4 bits (163), Expect = 5e-11 Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 23/295 (7%) Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNY-----SNIKIYNTPSASYLEVTPDSEN 472 EG VNI ++ P T++WF+ P + +++ L + + Sbjct: 16130 EGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRS 16189 Query: 473 DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVP 529 D G Y TAVN +G S E L P P + ++ S +A + + P+ GG Sbjct: 16190 DTGLYTITAVNNLGTASKEMRLNVLGRP-GPPVGPIKFESVSADQMTLSWFPPKDDGGSK 16248 Query: 530 ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 589 I Y E R + W + KE + TI L Y R+ A N G+GE Sbjct: 16249 ITNYVIEKREANRKTWVHVSSEPKECT----YTIPKLLEGHEYVFRIMAQNKYGIGEPLD 16304 Query: 590 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYR-ALSSEWK 647 + + + P AP NS+ VN + + DGGSP+ Y + + S WK Sbjct: 16305 SEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK 16364 Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702 R P +K++ Y+V + E + + + + P ++P++ Sbjct: 16365 RVNRDP-------IKAMTLGVSYKVTGLIEGSDYQFR-VYAINAAGVGPASLPSD 16411 Score = 67.4 bits (163), Expect = 5e-11 Identities = 65/271 (23%), Positives = 103/271 (38%), Gaps = 13/271 (4%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G V + P T W DG + + + ++ N +S L + D G Y Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNF--SSVLTIKNCLRRDTGEYQ 17582 Query: 479 CTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYK 534 T N G +++ L D P P+ I V P T + + P+ GG P++ Y Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT--ISWQPPKDDGGSPVINYI 17640 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594 E + ++ W S + + I L+ Y R+ A N G+G ++ Sbjct: 17641 VEKQDTRKDTWGV----VSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTV 17696 Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP 653 + PS P N+ V+ + + DGGSPI Y + R ++ +W + P Sbjct: 17697 AKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTP 17756 Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 + L YE V AEN G SK Sbjct: 17757 IADLKFRVTGLYEGNTYEFRVFAENLAGLSK 17787 Score = 67.4 bits (163), Expect = 5e-11 Identities = 115/500 (23%), Positives = 191/500 (38%), Gaps = 63/500 (12%) Query: 235 CDAEGFPEP--------TMSWTK---DGEQIEQEEDDEKYIFSDD-----------SSQL 272 CD G PEP T+ WTK DG + EK D +Q Sbjct: 23521 CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580 Query: 273 TIKKVDKNDEAEYICIAENKAGE-------------QDATIHLKVFAKPKITYVENQTAM 319 T+ + ++ E+ IA+N AG +D ++ PK + + Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKF---RDTIVV 23637 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E L + G P+P+I W + I + +++ + L +K D Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDKEIEESARC-----EIKNTDFKALLIVKDAIRID 23692 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438 G+YI ASN G S + ++V P +GPV V + ++T + Sbjct: 23693 GGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDIS 23752 Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQA 497 + +S + + + + L+VT E + + AVN+ G E LE V Sbjct: 23753 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 23812 Query: 498 DTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552 P S++ + V ++ P++ GG I+ Y E R + +W Sbjct: 23813 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKR----DRSGIRWIKC 23868 Query: 553 KEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS-EFKTQPVQGEPSAPKLEGQ 610 + + + + + GL + Y R++A N G+GE S A+ +K +P P Sbjct: 23869 NKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHI 23928 Query: 611 MGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RALSSEWKPEIRLPSGSDHVM---LKSLD 665 + NSI + K DGGS I Y+V +A EW +I P V + L Sbjct: 23929 VDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW--QIVTPQTGLRVTRFEISKLT 23986 Query: 666 WNAEYEVYVVAENQQGKSKA 685 + EY++ V A N+ G +A Sbjct: 23987 EHQEYKIRVCALNKVGLGEA 24006 Score = 67.4 bits (163), Expect = 5e-11 Identities = 117/517 (22%), Positives = 194/517 (37%), Gaps = 66/517 (12%) Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 + LT G P P W ++IS M+ S + L +K D+G Y Sbjct: 30154 IRLTIPIKGKPFPICKWTKEGQDISKRA------MIATSETH-TELVIKEADRGDSGTYD 30206 Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444 N G+ +++Y++V+ P ++ QV + P+ G + Sbjct: 30207 LVLENKCGK--KAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYI 30264 Query: 445 LPSSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFI---- 493 L Y S + L V EN ++ +A N+ G +S E + Sbjct: 30265 LERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 30324 Query: 494 -LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW--HSKWY 550 L + PS+P + ++ S+ + + P+ GG + Y E + + W H+K Sbjct: 30325 PLNPPEPPSNPP-EVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQ 30383 Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLEG 609 + T+ GL P+ Y R+ A N GL E S ASE + +PS P Sbjct: 30384 ITTT-----MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELE 30438 Query: 610 QMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWN 667 + +S+ + K + DGG I Y V YR S WK + + L Sbjct: 30439 ILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEA 30498 Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 727 EYE V AEN+ G S+ + TA+ TSG + G + Sbjct: 30499 TEYEFRVFAENETGLSR---------PRRTAMSIKTKLTSGEAPG-----------IRKE 30538 Query: 728 VVDITCYFLNKCGLFMCIAVNLCGKAGPGAK----GKDMEEGKAAFSKDESKEPIVEVRT 783 + D+T K G ++ + G+ P K GK++ + + + + + V T Sbjct: 30539 MKDVT----TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMT 30594 Query: 784 EEERTPNHDGGKHT--EPNETTPLTEPEKGPVEAKPE 818 EE+ D G +T NE + K ++A P+ Sbjct: 30595 EEQ----EDEGVYTCIATNEVGEVETSSKLLLQATPQ 30627 Score = 67.4 bits (163), Expect = 5e-11 Identities = 86/413 (20%), Positives = 160/413 (38%), Gaps = 35/413 (8%) Query: 95 KCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154 K +V E S+A+ V+ ++ K T EG+ V+ ++ + + W Sbjct: 33018 KSIVHEEITKTSQASEEVRTHAEI--KAFSTQMSINEGQRLVLKANIAGATD--VKWVLN 33073 Query: 155 GRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRC-----EGRILARGEINFK----DI 204 G ++ ++ R+ V S+ L I+ DEG C EG + + ++ D Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133 Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264 ++ P + QNI N GQ+V C+ G P P + W K+ I + Sbjct: 33134 PAFISQPRS----QNI-----NEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSIS 33183 Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324 S + L I+ +D +Y A+N G+ AT L V P + + + Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL--PLVEEPSREVVLRTSGD 33241 Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT----DA 380 +L S + ++ + SS + M A +S+ ++ S+Q + + Sbjct: 33242 TSLQGSFSSQSV-QMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSS 33300 Query: 381 GEYICTASNTIGQDSQSMYLEVQYA---PKLQG-PVAVYTWEGNQVNITCEVFAYPSATI 436 ++ ++ T + S S L+ PK++ P + EG + + C P+ + Sbjct: 33301 SSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEV 33360 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 +W G+ + S I NT + L + + D G Y + N G +S Sbjct: 33361 TWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 33413 Score = 67.0 bits (162), Expect = 7e-11 Identities = 77/295 (26%), Positives = 116/295 (39%), Gaps = 36/295 (12%) Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465 PK + + V+ G + +++ P TI W + Q L SN + ++I +T A+ L Sbjct: 22547 PKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQEL--SNTARLEIKSTDFATSLS 22602 Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDE 521 V D GNY A N G+ S+ + D P P I V T + + Sbjct: 22603 VKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT--LAWKP 22660 Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNG 581 P GG I+ Y E R VW DA ++ VT L Y R+ A+N Sbjct: 22661 PLQDGGSDIINYIVERRETSRLVW--TVVDANVQTLSCKVT--KLLEGNEYTFRIMAVNK 22716 Query: 582 KGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-----------DGGS 630 G+GE P++ EP K + + + +V + +D DGGS Sbjct: 22717 YGVGE----------PLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGS 22766 Query: 631 PIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 I Y++ R W + G + + L N +YE V AEN G S+ Sbjct: 22767 EILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSE 22821 Score = 67.0 bits (162), Expect = 7e-11 Identities = 85/348 (24%), Positives = 126/348 (36%), Gaps = 57/348 (16%) Query: 189 CEGRILARGEINFKDIQVI-VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247 C G I ++ ++ ++V + + P I++A G V VC E + + T Sbjct: 31545 CGGAIRSQKGVSVAKVKVASIEIGPV---SGQIMHAVGEEGGHVKYVCKIENYDQSTQVT 31601 Query: 248 TKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305 G + Q E+ EKY + D + L +K + K D+ Y C N GE + + ++F Sbjct: 31602 WYFG--VRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS--YAELF 31657 Query: 306 AK------------------------------PKITY-VENQTAMELEEQVTLTCEASGD 334 K P+ T + N+TA + E V + Sbjct: 31658 VKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAY-VGENVRFGVTITVH 31716 Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394 P P +TW S + I + D S + LT+ S+ D EY A N G+D Sbjct: 31717 PEPHVTWYKSGQKIKPGDN--DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGED 31774 Query: 395 SQSMYLEVQYAPKLQGPVA----------VYTWEGNQVNITCEVFAYPSATISWFRDGQL 444 S L V P EG V V P T+ W +DGQ Sbjct: 31775 SCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQ- 31833 Query: 445 LPSSNYSNIKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIGQESLE 491 P S NI+I + Y L + D G Y TA N G S + Sbjct: 31834 -PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880 Score = 66.6 bits (161), Expect = 9e-11 Identities = 70/274 (25%), Positives = 108/274 (39%), Gaps = 13/274 (4%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G + I V P ++WF+DG + N++I + ++ L V + + G Y Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDG--VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030 Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535 A N G E + DTP + + + T + + +D P G PI Y Sbjct: 28031 VEAKNASGSAKAEIKVKVQDTPGKV-VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYII 28089 Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595 E R W + S I I G Y R++A+N G+G + Sbjct: 28090 EKRETSRLAWALIEDKCEAQSYTAIKLING----NEYQFRVSAVNKFGVGRPLDSDPVVA 28145 Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLV-RYRALSSEWKPEI-RL 652 Q P AP + GNSI + + + DGGS I+ Y++ R S+ W I + Sbjct: 28146 QIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKR 28205 Query: 653 PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 P + L EYE +V+AEN G A+ Sbjct: 28206 PISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 28239 Score = 66.2 bits (160), Expect = 1e-10 Identities = 76/325 (23%), Positives = 130/325 (40%), Gaps = 16/325 (4%) Query: 369 SLTLKSIQYTDAGEYICTASNTIG----QDSQSMY--LEVQYAPKLQGPVAVYTWEGNQV 422 SL + ++ ++ A N +G ++++ +Y E PK+ P + G ++ Sbjct: 18857 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 18916 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 I V+ P T W + + +S S++ ++ S+S L + + D G Y+ TA Sbjct: 18917 RIEAHVYGKPHPTCKWKKGEDEVVTS--SHLAVHKADSSSILIIKDVTRKDSGYYSLTAE 18974 Query: 483 NRIGQES--LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540 N G ++ ++ +++ A P P D + + + + P GG I Y E Sbjct: 18975 NSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKC-- 19032 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600 +V W A + + + L P Y R+ A N G+ E + + Q G Sbjct: 19033 --DVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFG 19090 Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDH 658 PS PK + + I V + D DGGSPI YL+ + +S W S Sbjct: 19091 VPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTE 19150 Query: 659 VMLKSLDWNAEYEVYVVAENQQGKS 683 L EY + A N+ G S Sbjct: 19151 YPCAGLVEGLEYSFRIYALNKAGSS 19175 Score = 65.5 bits (158), Expect = 2e-10 Identities = 72/293 (24%), Positives = 122/293 (41%), Gaps = 44/293 (15%) Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 + + SG P P++TW + E+TL + + A SS+ +K+ Q + G Y Sbjct: 16542 IRIIAYVSGKPPPTVTWNMN-------ERTLPQEATIETTAISSSMVIKNCQRSHQGVYS 16594 Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDG 442 A N G+ +++ ++V P GPV N N +C+ ++WF D Sbjct: 16595 LLAKNEAGERKKTIIVDVLDVP---GPVGTPFLAHNLTNESCK--------LTWFSPEDD 16643 Query: 443 QLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----E 488 P +NY K + T + V + + A N IG E Sbjct: 16644 GGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVE 16703 Query: 489 SLEFILVQAD--TPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545 + E ++++ P P ++ E +T + ++ P+ GG I+ Y E R +G E + Sbjct: 16704 TSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKF 16763 Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598 H D + T+ GLK TY R++A+N G G+ S F T+P+ Sbjct: 16764 HKVTNDNL---LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS----FCTKPI 16809 Score = 65.5 bits (158), Expect = 2e-10 Identities = 99/405 (24%), Positives = 150/405 (37%), Gaps = 49/405 (12%) Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 VPP+++ ++ G +V G P PT WT DG +I+ DE Y D Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKT---DEHYTVETD 17562 Query: 269 --SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT 326 SS LTIK + D EY N AG + +HL V P E +T Sbjct: 17563 NFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT 17622 Query: 327 LTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 ++ + D P I + + ++ D VV S + + L + +Q + Sbjct: 17623 ISWQPPKDDGGSPVINY-----IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFR 17677 Query: 385 CTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF- 439 A N IG DS + +++P V T +IT +AT+SW Sbjct: 17678 VRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVT------DIT-----ENAATVSWTL 17726 Query: 440 --RDGQLLPSSNYSN--------IKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIG-- 486 DG + Y +++ TP A VT E + + A N G Sbjct: 17727 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786 Query: 487 QESLEFILVQADTPSSPSIDQVEP-----YSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541 + S ++A P P + P TA + + +P + GG PIL Y E + G Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846 Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586 W+ + E + + GL Y R+ A N G GE Sbjct: 17847 TAQWNR--INKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889 Score = 65.1 bits (157), Expect = 3e-10 Identities = 101/431 (23%), Positives = 167/431 (38%), Gaps = 60/431 (13%) Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89 E+S ++ +C+V+ + + W+ + E + + I + L I NA+++ Sbjct: 12473 EVSETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILT---EGRKRILVIQNAHLE 12527 Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVVSSLPPT 148 DAG Y C + S VK+ + F + P E EGE A VC + P Sbjct: 12528 DAGNYNCRLPS-----SRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP- 12581 Query: 149 IIWKHKGR--------DVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200 + WK + DVI R +V+ + LQ G G R + Sbjct: 12582 VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV----- 12636 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDA--EGFPEPTMSWTKDGEQIEQEE 258 + ++++V + T Q Q V C+ EG W ++ E I Sbjct: 12637 IEKLRIVVPLKDTRVKEQ----------QEVVFNCEVNTEG---AKAKWFRNEEAIF--- 12680 Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 D KYI D L I+ +D+A Y N GE + + + + VE Sbjct: 12681 DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPL 12740 Query: 317 TAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 +E E+ VT C+ + + ++ W T+N EE D + R LT+K Sbjct: 12741 KDIETMEKKSVTFWCKVNRLNV-TLKW---TKN--GEEVPFDNRVSYRVDKYKHMLTIKD 12794 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFAYP 432 + D GEYI TA GQD L + AP ++ E + +C++ + Sbjct: 12795 CGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQL-SRE 12849 Query: 433 SATISWFRDGQ 443 A + W+R+G+ Sbjct: 12850 KANVKWYRNGR 12860 Score = 64.7 bits (156), Expect = 3e-10 Identities = 74/331 (22%), Positives = 120/331 (36%), Gaps = 58/331 (17%) Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270 PPT+ + + N T G+SVTL C G+P PT++W ++ QIE D + F + Sbjct: 942 PPTLVS--GLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIA 998 Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330 +L I++ D + C A N+AG + +L V Q + E E++ T Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV-----------QVSEEFEKETTAV-- 1045 Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390 T ++EEK +R +T S+ AG Sbjct: 1046 --------------TEKFTTEEKRF-------VESRDVVMTDTSLTEEQAGP-------- 1076 Query: 391 IGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450 G+ + ++ KL EG V C+V P + W + G L + Sbjct: 1077 -GEPAAPYFITKPVVQKLV--------EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYR 1127 Query: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE-FILVQADTPSSPSIDQVE 509 + L ++ +D G Y N+ G+ S +L +AD Q Sbjct: 1128 YKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEM 1187 Query: 510 PYSSTAQVQFDEP---EATGGVPILKYKAEW 537 Y + EP E G +Y+ E+ Sbjct: 1188 LYQTQVTAFVQEPKVGETAPGFVYSEYEKEY 1218 Score = 64.7 bits (156), Expect = 3e-10 Identities = 59/279 (21%), Positives = 115/279 (41%), Gaps = 14/279 (5%) Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473 ++ +G + +T + P W ++GQ + I + + + L + D Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISK----RAMIATSETHTELVIKEADRGD 30201 Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPIL 531 G Y+ N+ G++++ + +P+SP ++ + + +V + P GG IL Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261 Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591 Y E R V + W++ + S+ + GLK Y R++A N G+ + + Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGTSL----VVKGLKENVEYHFRVSAENQFGISKPLKSE 30317 Query: 592 EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIR-HYLVRYRALSSEWK 647 E T P P D V+L +DDGGS + +Y+ R + +W Sbjct: 30318 EPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWV 30377 Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 + + + L +AEY+ ++A+N G S+ + Sbjct: 30378 RHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETS 30416 Score = 63.9 bits (154), Expect = 6e-10 Identities = 114/554 (20%), Positives = 216/554 (38%), Gaps = 65/554 (11%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100 C+V+ KD + WF +GE++ P+ + + D L I A++ D G Y C G Sbjct: 11684 CEVS---KDVPVKWFK-DGEEIVPSPKYS--IKADGLRRILKIKKADLKDKGEYVCDC-G 11736 Query: 101 EDGSESEATVNVKIF--QKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158 D +++ TV ++ +K ++ E E + DV WK KG+ + Sbjct: 11737 TDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQ------WKLKGQPL 11790 Query: 159 ILKKDVRFIVLSNNYLQIRG---IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQ 215 D I ++ I + T E +++ A + K++ +I P Sbjct: 11791 TASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA-ANLKVKELPLIFITP---- 11845 Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ-LTI 274 + + C+ P+ T W K ++I DD + D + + I Sbjct: 11846 ----LSDVKVFEKDEAKFECEVSREPK-TFRWLKGTQEITG--DDRFELIKDGTKHSMVI 11898 Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334 K DEA+Y+ AE+K + ++ +T +++ TA E +E T E S D Sbjct: 11899 KSAAFEDEAKYMFEAEDK--HTSGKLIIEGIRLKFLTPLKDVTAKE-KESAVFTVELSHD 11955 Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394 I + W + + + + + ++ + S+T K + D + A +G Sbjct: 11956 NI-RVKWFKNDQRLHTTRS-----VSMQDEGKTHSITFKDLSIDDTSQIRVEA---MGMS 12006 Query: 395 SQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453 S++ ++ P G + YT E ++V + CE+ + A + WF+DG+ + S + I Sbjct: 12007 SEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGKEIKPSKNAVI 12065 Query: 454 KIYNTPSASYLEVTPDSENDFGNYNC-----TAVNRIGQESLEFILVQADTPSSPSIDQV 508 K L+ ++D G Y C ++ E E LV+ S++ + Sbjct: 12066 KADGKKRMLILKKA--LKSDIGQYTCDCGTDKTSGKLDIEDREIKLVR----PLHSVEVM 12119 Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568 E ++ + + E + A W+ GE + + + KE + + + Sbjct: 12120 ETETARFETEISEDD---------IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRL 12170 Query: 569 ETTYAVRLAALNGK 582 + T V A N K Sbjct: 12171 DQTGGVDFQAANVK 12184 Score = 63.9 bits (154), Expect = 6e-10 Identities = 106/496 (21%), Positives = 176/496 (35%), Gaps = 58/496 (11%) Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD- 278 + T G + L G PEP ++WTK ++Q D++ + + T+ VD Sbjct: 13697 LAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITIENVPKKSTVTIVDS 13753 Query: 279 -KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP 337 ++D YI A N G A + + V KP A ++ + +C + +P P Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDKP-----GPPAAFDITDVTNESCLLTWNP-P 13807 Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNT--IGQ 393 + N E + D + + + V K+ + EYI A N +G+ Sbjct: 13808 RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGE 13867 Query: 394 DSQSMYLEVQYAPKLQGP------------VAVYTW-----EGNQVNITCEVFAYPSATI 436 Q+ + +Y GP TW +G V T Sbjct: 13868 PVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD 13927 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496 W R ++ +K V ++ G +S E IL++ Sbjct: 13928 KWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK---------PSKSTEPILIK 13978 Query: 497 --ADTPSSPSIDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553 D P P V+ T+ ++ + +PE GG I Y E G + W Sbjct: 13979 DPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW-------- 14030 Query: 554 EASMEGIVT----IVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLE 608 EG+ T + GL Y+ R+ A+N G E S S+ + PS P+ Sbjct: 14031 VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWL 14090 Query: 609 GQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWN 667 + N+ + + + DGGSPI +Y+V R + + + + L Sbjct: 14091 EVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEG 14150 Query: 668 AEYEVYVVAENQQGKS 683 + Y V AEN G+S Sbjct: 14151 SLYVFRVAAENAIGQS 14166 Score = 63.5 bits (153), Expect = 8e-10 Identities = 92/389 (23%), Positives = 154/389 (39%), Gaps = 52/389 (13%) Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 V L +G P P+ +W + + E+ + V +H +V+ LT++ D GEY Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESER-----VTVETHTKVAKLTIRETTIRDTGEYT 29810 Query: 385 CTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FR 440 N G S+++ + + P GP+ + ++++ T S TISW Sbjct: 29811 LELKNVTGTTSETIKVIILDKPGPPTGPIKI-----DEIDAT-------SITISWEPPEL 29858 Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES- 489 DG P S Y + + + + S + T +E + + A NR G S Sbjct: 29859 DGG-APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSY 29917 Query: 490 LEFILVQADT----PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEV 544 L+ +++ + P P Q+ S + + PE GG + Y E +EV Sbjct: 29918 LQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE----RKEV 29973 Query: 545 WHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603 +W + + GL Y R+ A+N +G G+ S S+ V +P Sbjct: 29974 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK---PIVAMDPI 30030 Query: 604 AP--KLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSD 657 AP K + D V+L + +D+GGS + YL+ + + EW P+ Sbjct: 30031 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 30090 Query: 658 HVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 L L AEY V+A N G + A Sbjct: 30091 EYTLTHLPQGAEYRFRVLACNAGGPGEPA 30119 Score = 62.8 bits (151), Expect = 1e-09 Identities = 95/440 (21%), Positives = 166/440 (37%), Gaps = 49/440 (11%) Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDA-TIHLKVFAK-----PKITYVENQTAMELE 322 S Q I + + +E + +A N+ G D ++ + + AK P + + ++++ Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 + + + SG P P+ITW + + + V +++L++K D G+ Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQTTR-----INVTDSLDLTTLSIKETHKDDGGQ 23299 Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 Y T +N +GQ + S+ + P +GPV + ++ P + Sbjct: 23300 YGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN----PPLYTGGCQI 23355 Query: 442 GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIGQE-SLEFILVQ 496 + + +++ SA+ L+VT + A NR GQ +LE + Sbjct: 23356 TNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIV 23415 Query: 497 ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAE--------WRAVGEE 543 A P P+++ +Q+ EP GG P++ Y E W V + Sbjct: 23416 AQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKT 23475 Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603 + H + A+ EGI Y R+ A N G+G+ S SE +P Sbjct: 23476 IIHDTQFKAQNLE-EGI----------EYEFRVYAENIVGVGKASKNSECYVARDPCDP- 23523 Query: 604 APKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVML 661 P + N I + K DGGS I Y+V R L W + Sbjct: 23524 -PGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTV 23582 Query: 662 KSLDWNAEYEVYVVAENQQG 681 L + YE V+A+N G Sbjct: 23583 SGLTEDQRYEFRVIAKNAAG 23602 Score = 62.8 bits (151), Expect = 1e-09 Identities = 81/342 (23%), Positives = 136/342 (39%), Gaps = 57/342 (16%) Query: 271 QLTIKKVDKNDEAEY-ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329 Q T+ K+ +N E + IC ++ + AT+ V A+ +I E + +L + V L Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121 Query: 330 EAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS----LTLKSIQY 377 A+ G P P + W + +G + R+ V+S L + ++ Sbjct: 25122 SATLRLFVTIKGRPEPEVKWEKA-----------EGILTDRAQIEVTSSFTMLVIDNVTR 25170 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 D+G Y T N G S++ ++ V+ PV N+T S T+S Sbjct: 25171 FDSGRYNLTLENNSG--SKTAFVNVRVLDSPSAPV----------NLTIREVKKDSVTLS 25218 Query: 438 W---FRDG-----QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN----YNCTAVNRI 485 W DG + + K Y T + + + T EN + A N Sbjct: 25219 WEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEY 25278 Query: 486 G----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541 G E+ E + V + V+ +TA +++++PE+ GG I Y E + G Sbjct: 25279 GIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKG 25338 Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583 E W + + ++E TI GL Y R+AA+N KG Sbjct: 25339 SEKWST---CTQVKTLE--ATISGLTAGEEYVFRVAAVNEKG 25375 Score = 62.4 bits (150), Expect = 2e-09 Identities = 101/460 (21%), Positives = 180/460 (39%), Gaps = 63/460 (13%) Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---------KPKITYVENQTAM 319 ++ ++ +D++ E+ A N+ GE + ++ L V K +++ + + Sbjct: 15351 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKV 15410 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV-----RSHARVSSLTLKS 374 + E V + + +G P+P I W ++N + EK D + RS A+ K+ Sbjct: 15411 KAGEPVHIPADVTGLPMPKIEW---SKNETVIEKPTDALQITKEEVSRSEAKTELSIPKA 15467 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNIT 425 ++ D G Y TASN +G +++++EV P +AV TW+ N Sbjct: 15468 VR-EDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGG 15526 Query: 426 CEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NY 477 E+ Y W Y K+ P+ Y E + N +G + Sbjct: 15527 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKL--IPNGQY-EFRVRAVNKYGISD 15583 Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 C + + Q+ P P + + + V + P GG PI Y E Sbjct: 15584 ECKSDKVVIQDPYRL----PGPPGKPKV--LARTKGSMLVSWTPPLDNGGSPITGYWLEK 15637 Query: 538 RAVGEEVW-HSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS--EF 593 R G W + ++G+ + L Y R A+N G+G S S E Sbjct: 15638 REEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEV 15697 Query: 594 KTQPV--QGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRAL-SSEWK 647 P+ G PS P++ +D ++L DGGSPI+ Y+V + +++WK Sbjct: 15698 AGDPIFPPGPPSCPEV-----KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWK 15752 Query: 648 PEIRLPS---GSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 + P + ++ +L +Y V A N+ G+S+ Sbjct: 15753 -RVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESE 15791 Score = 62.0 bits (149), Expect = 2e-09 Identities = 97/415 (23%), Positives = 163/415 (39%), Gaps = 66/415 (15%) Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83 + P + GE+ F C+V G + K ++W+ NG+ L +R V + D L I Sbjct: 1845 LYPEPVRVLEGETARFRCRVTGYPQPK-VNWYL-NGQ-LIRKSKRFRVRY--DGIHYLDI 1899 Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKN----APTPQ-EFREGEDAVIV 138 + D G K +G E V ++I Q+ F++ AP P+ EF E + Sbjct: 1900 VDCKSYDTGEVKVTAENPEGV-IEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQ 1958 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNYLQIRGIKKTDEGTYRC----- 189 +V P + K V LK+ R + + L+ + ++T+EG Y Sbjct: 1959 FEVQKVDRPVDTTETK-EVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVE 2017 Query: 190 -------------------------------EGRILAR-GEINFKDIQVI-VNVPPTIQA 216 E + LA G+I + + + P+++A Sbjct: 2018 LKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEA 2077 Query: 217 R---QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273 + I + T G G P+P W K+G +IE+ + Y D+ +L Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV 2137 Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY---VENQTAMELEEQVTLTCE 330 I+ V D A + A N AGE + L V AK IT+ +++ A E + T CE Sbjct: 2138 IRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECE 2197 Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 S +P + W + +K + S +V L++ +I +DA +Y C Sbjct: 2198 TS-EPFVKVKWYKDGMEVHEGDK-----YRMHSDRKVHFLSILTIDTSDAEDYSC 2246 Score = 61.6 bits (148), Expect = 3e-09 Identities = 97/392 (24%), Positives = 157/392 (40%), Gaps = 61/392 (15%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 E + + + +G P+P I+W I EE+ + +H + LT+K D G+ Sbjct: 25805 EVLKINADIAGRPLPVISWAKD--GIEIEERARTEIISTDNH---TLLTVKDCIRRDTGQ 25859 Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR- 440 Y+ T N G S ++ +V P GP+ + +T E ++SW R Sbjct: 25860 YVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN-------GLTAE-----KCSLSWGRP 25907 Query: 441 --DGQLLPSSNYSNIKIYNTPSASYL-----------EVTPDSENDFGNYNCTAVNRIGQ 487 DG +Y ++ T ++ +VT + + + T VN+ G Sbjct: 25908 QEDGGA--DIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGV 25965 Query: 488 -ESLEFILVQA----DTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541 E LE + ++A PS P S++ + + + PE+ GG I Y E R Sbjct: 25966 GEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKN 26025 Query: 542 EEVW----HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KT 595 W YD + S GL+ Y R+ A N GL S S Sbjct: 26026 SLRWVRVNKKPVYDLRVKS-------TGLREGCEYEYRVYAENAAGLSLPSETSPLIRAE 26078 Query: 596 QPV--QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RALSSEWKPEIR 651 PV PS PK+ + +I + +K DGG+PI Y V Y ++ ++WK I+ Sbjct: 26079 DPVFLPSPPSKPKI---VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQ 26135 Query: 652 LPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 G+++ + L AEY V + N+ G S Sbjct: 26136 SLRGTEYT-ISGLTTGAEYVFRVKSVNKVGAS 26166 Score = 61.2 bits (147), Expect = 4e-09 Identities = 50/180 (27%), Positives = 81/180 (45%), Gaps = 9/180 (5%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE-DDEKYIFSDDSSQLTIKKVDKNDEAEYI 286 G + T GFP P +SW +DG+ I + FSD ++LTI V K + Y Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79 Query: 287 CIAENKAGEQDATIHLKVFAK-PKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRT 343 A N +G+ +T L V A+ +V+ +M + + QV L +G P P + + Sbjct: 80 LKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYR 139 Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403 I S +LD + + SL + D+G Y A+N++G+ + + L VQ Sbjct: 140 DGAEIQS---SLD--FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194 Score = 61.2 bits (147), Expect = 4e-09 Identities = 124/583 (21%), Positives = 233/583 (39%), Gaps = 79/583 (13%) Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98 F CQ++ + + + W+ NG ++ ++ D S L I + +DD Y C Sbjct: 12842 FSCQLSREKAN--VKWYR-NGREIKEGKKY--KFEKDGSIHRLIIKDCRLDDECEYAC-- 12894 Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158 G + +S A + V +++ + PQ+ E A +V + + + V Sbjct: 12895 -GVEDRKSRARLFV---EEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMV 12950 Query: 159 ILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRIL-ARGEINFKDIQVIVNVPPTIQ 215 +++ D ++ LQI IK D+G YR + AR ++ + P Sbjct: 12951 VVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLE------LAAAPKIKT 13004 Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275 A Q++V ++G+ +T+V + +P+ W K+ E + + D + + + I Sbjct: 13005 ADQDLV---VDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDT----TAEQTSFRIL 13057 Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKP------KITYV-ENQTAMELEEQVTLT 328 + K D+ Y + +NK G+ + I+LKV P ++T + + ++ EE +T Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPLT-- 13115 Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388 G I I + R+I + L V+ L ++Y + +A Sbjct: 13116 --DGGSKI--IGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYL----FRVSAR 13167 Query: 389 NTIGQ----------DSQSMY------LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP 432 N +G +++S Y L V + V++ TWE + + E+ Y Sbjct: 13168 NRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSL-TWEPPEYDGGAEITNY- 13225 Query: 433 SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488 + RD + ++ + SA+ +V E F A NRIG Sbjct: 13226 ---VIELRDKTSIRWDTAMTVRAEDL-SATVTDVVEGQEYSF---RVRAQNRIGVGKPSA 13278 Query: 489 SLEFILVQ--ADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545 + F+ V + PS P ++ + S+ Q++++ P GG PIL Y E G++ W Sbjct: 13279 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 13338 Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588 + E + GL+ Y R++A N G+ + S Sbjct: 13339 IR---CNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPS 13378 Score = 61.2 bits (147), Expect = 4e-09 Identities = 113/473 (23%), Positives = 182/473 (38%), Gaps = 53/473 (11%) Query: 273 TIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKITYVENQTAMELE--EQVTL 327 T K +++ E ++ AEN AG + AT K V +T++E++ +++ L Sbjct: 14640 TAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIAL 14699 Query: 328 TCEASGDPIPSITWRTSTRNISSEE-KTLDGHMVVRSHARVSS-------LTLK-SIQYT 378 SG P P+ITW I EE K +V R V LT + SI + Sbjct: 14700 DASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNS 14759 Query: 379 DAGEYICTASNTIGQDSQSMYLEVQY---APKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 GE +++ D ++V+ K V+V G +N E S Sbjct: 14760 KKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVL 14819 Query: 436 ISW---FRDG-------------QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479 W DG + P S + I + +T VT E + Sbjct: 14820 CKWEPPLDDGGSEIINYTLEKKDKTKPDSEW--IVVTSTLRHCKYSVTKLIEGKEYLFRV 14877 Query: 480 TAVNRI--GQESLEFILVQAD---TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKY 533 A NR G + LV D P +P VE +S + V+++EP+ G PIL Y Sbjct: 14878 RAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGY 14936 Query: 534 KAEWRAVGEEVW---HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590 E R V W + +A +A+++G+ + GL TY R+ A N G G+ S Sbjct: 14937 WLEKREVNSTHWSRVNKSLLNALKANVDGL--LEGL----TYVFRVCAENAAGPGKFSPP 14990 Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ--DDGGSPIRHYLVRYRALSSEWKP 648 S+ KT P P + +I++ + GG + +++ + ++EW Sbjct: 14991 SDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSR 15050 Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 701 +K + A+Y++ V A N G+ T A+P PA Sbjct: 15051 CTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPA 15103 Score = 60.8 bits (146), Expect = 5e-09 Identities = 137/625 (21%), Positives = 229/625 (36%), Gaps = 92/625 (14%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 +S GE C V G + I W G ++ P+ R S + ++ L + + D Sbjct: 8357 VSEGEYVQLSCHVQGSEPIR-IQWLKA-GREIKPSD-RCSFSFAS-GTAVLELRDVAKAD 8412 Query: 91 AGIYKCV---VTGEDGSESEATVNVK-----------IFQKLMFKNAPTPQEFREGEDAV 136 +G Y C V G D ++S+ T+ K + +L F + P E A Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472 Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN---YLQIRGIKKTDEGTYRCEGRI 193 + V P + W KG+ L + R + L+IR KTD G YRC Sbjct: 8473 FIAKVGGDPIPNVKWT-KGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVA-F 8530 Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT---MSWTKD 250 GEI VN+ + +Q + T + E M K+ Sbjct: 8531 NEHGEIESN-----VNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKN 8585 Query: 251 GEQIEQEEDDEKYIFSDDSSQLT---IKKVDKNDEAEYICIAENKAGEQD--------AT 299 + E E+ Y +D L + K + +E + I E + E+D + Sbjct: 8586 VDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSF 8645 Query: 300 IHLKVFAKPKITYV---ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--- 353 I ++ +T + ENQT ++ + V P ++W T + +K Sbjct: 8646 IQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEI 8705 Query: 354 TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA 413 ++DG +L +K+ Q D G Y I ++ +E + LQ Sbjct: 8706 SIDGDR--------HTLRVKNCQLKDQGNYRLVCGPHIASAKLTV-IEPAWERHLQD--- 8753 Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473 V EG +TC+ F+ P+ WFR+G++L ++ + L + D Sbjct: 8754 VTLKEGQTCTMTCQ-FSVPNVKSEWFRNGRILKPQGRHKTEVEH--KVHKLTIADVRAED 8810 Query: 474 FGNYNC-------TAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST--AQVQFDEPEA 524 G Y C +A RI E ++F T +I E S+T +V FD+ Sbjct: 8811 QGQYTCKYEDLETSAELRIEAEPIQF------TKRIQNIVVSEHQSATFECEVSFDDAIV 8864 Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP--ETTYAVRLAALNGK 582 T W E+ S+ Y+ + +TI + P E Y+V +A L + Sbjct: 8865 T-----------WYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSV-IARLEPR 8912 Query: 583 GLGEISAASEFKTQPVQGEPSAPKL 607 G +A T+ ++ E P + Sbjct: 8913 GEARSTAELYLTTKEIKLELKPPDI 8937 Score = 60.8 bits (146), Expect = 5e-09 Identities = 65/266 (24%), Positives = 105/266 (39%), Gaps = 12/266 (4%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G+ + ++ + P ++W ++ + P+ +I TP S LE+ + D G Y+ Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTK----ARIDVTPVGSKLEIRNAAHEDGGIYS 17288 Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 T N G +++ ++ D P P ++ E + + + EP GG I Y E Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596 R V W +K+ S L Y R+AA N G G + K Sbjct: 17349 RDVASAQWSPLSATSKKKSH----FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKAL 17404 Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSG 655 P PK + D + + K D DGGSPI YLV Y+ ++ + + + Sbjct: 17405 DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTN 17464 Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQG 681 + V + L Y V AEN G Sbjct: 17465 LECV-VTGLQQGKTYRFRVKAENIVG 17489 Score = 60.1 bits (144), Expect = 9e-09 Identities = 95/425 (22%), Positives = 158/425 (37%), Gaps = 48/425 (11%) Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 V L G P+P+++W+ + E + + + +L L S+ D+G+Y Sbjct: 19313 VCLDATVFGKPMPTVSWKKDGTLLKPAEG-----IKMAMQRNLCTLELFSVNRKDSGDYT 19367 Query: 385 CTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY---- 431 TA N+ G S ++ L+V P K+ A+ +WE + E+ Y Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427 Query: 432 -PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490 ++ +W + +P ++ S K+ E + A N+ G Sbjct: 19428 RETSRPNWAQVSATVPITSCSVEKLI--------------EGHEYQFRICAENKYGVGDP 19473 Query: 491 EFILVQ-ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAEWRAVGEEV 544 F A P P P S V + P GG PI Y E R Sbjct: 19474 VFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVN 19533 Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK-TQPVQGEPS 603 W ++ +E + GL+ T Y R+ A+N G G+ S AS+ + Q P Sbjct: 19534 WTKV---NRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPG 19590 Query: 604 APKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLK 662 P +S+ ++ K DGGSPI YLV + S+ LP + Sbjct: 19591 PPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFE 19650 Query: 663 --SLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV--GIL 718 L + +Y+ V A N+ G S + + + IP G + L I+ G+ Sbjct: 19651 VTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVT 19710 Query: 719 IVIFV 723 + ++V Sbjct: 19711 MRLYV 19715 Score = 60.1 bits (144), Expect = 9e-09 Identities = 83/356 (23%), Positives = 135/356 (37%), Gaps = 49/356 (13%) Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLT 328 ++ I K+ ++ E + A NK G +AT + V + K+ E EL + + + Sbjct: 23978 TRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVR 24037 Query: 329 CEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380 S G P P ITW S EE + + + L++ + DA Sbjct: 24038 AGGSARIHIPFKGRPTPEITW-------SREEGEFTDKVQIEKGVNYTQLSIDNCDRNDA 24090 Query: 381 GEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY 431 G+YI N+ G S + ++V P +++ A WE ++ +V Y Sbjct: 24091 GKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNY 24150 Query: 432 PSATISWFRDGQLLPSSNYS--NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 R SS S + K+ N + +EN+FG +G Sbjct: 24151 VIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFG---------VGVPV 24201 Query: 490 LEFILVQADTPSSP--SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547 V+A P SP + + ++A + +++PE GG +L Y E + G E Sbjct: 24202 ETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTE---- 24257 Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG------LGEISAASEFKTQP 597 KW E+ + V + GL Y R+ A N KG LG A + QP Sbjct: 24258 KWSIVAESKVCNAV-VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQP 24312 Score = 59.7 bits (143), Expect = 1e-08 Identities = 93/363 (25%), Positives = 137/363 (37%), Gaps = 69/363 (19%) Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367 PKI E Q ++ +++ + G P P+ W+ +E H+ V Sbjct: 18900 PKILMPE-QITIKAGKKLRIEAHVYGKPHPTCKWKKG-----EDEVVTSSHLAVHKADSS 18953 Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTW 417 S L +K + D+G Y TA N+ G D+Q + + V AP + +W Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 19013 Query: 418 ----EGNQVNIT------CE------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461 E NIT C+ V A S T + R G+L+P Y I+ Sbjct: 19014 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEY----IFRV--- 19066 Query: 462 SYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQF 519 +EN FG + T+ + Q PS P +V + V + Sbjct: 19067 -------RAENRFGISEPLTSPKMVAQ-------FPFGVPSEPKNARVTKVNKDCIFVAW 19112 Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579 D P++ GG PI+ Y E + +W K D S E GL Y+ R+ AL Sbjct: 19113 DRPDSDGGSPIIGYLIERKERNSLLW-VKANDTLVRSTE--YPCAGLVEGLEYSFRIYAL 19169 Query: 580 NGKGLGEISAASEFKT--QPVQGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIRH 634 N G S +E+ T PV P P++ D V+LI + DGGS I Sbjct: 19170 NKAGSSPPSKPTEYVTARMPVD-PPGKPEV-----IDVTKSTVSLIWARPKHDGGSKIIG 19223 Query: 635 YLV 637 Y V Sbjct: 19224 YFV 19226 Score = 59.3 bits (142), Expect = 1e-08 Identities = 104/493 (21%), Positives = 195/493 (39%), Gaps = 59/493 (11%) Query: 168 VLSNNYLQIRGIKKTDEGTYRCEG-RILARGEINFKDIQVIVN---VPPTIQA--RQNIV 221 +LS Y ++G+K+ D YR I+ +G+ +F + PPT+ R + Sbjct: 16771 LLSRKYT-VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKL- 16828 Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK-KVDKN 280 T +G++ L G P+P +SW KD + + EDD +I + ++ K K ++ Sbjct: 16829 --TIRVGEAFALTGRYSGKPKPKVSWFKD--EADVLEDDRTHIKTTPATLALEKIKAKRS 16884 Query: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340 D +Y + EN G + + V +P ++ + ++ + P+ Sbjct: 16885 DSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKP---PLDDGG 16941 Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT--ASNTIGQDSQSM 398 + + I +E D M V S + + T K + + +YI A N G + Sbjct: 16942 SKITNYIIEKKEVGKDVWMPVTSAS--AKTTCKVSKLLEGKDYIFRIHAENLYGISDPLV 16999 Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--DGQLLPSSNYSNIKIY 456 ++ + + P + I EV SA ++W + DG P +NY ++ Sbjct: 17000 SDSMKAKDRFRVP------DAPDQPIVTEV-TKDSALVTWNKPHDGGK-PITNYI-LEKR 17050 Query: 457 NTPSASYLEVTPDSENDFGNYN-------CTAVNRIGQESLEFILVQADTPSSPSI---- 505 T S + VT D + + + C R+ E+ E + PS P Sbjct: 17051 ETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAEN-EIGIGDPSPPSKPVFAKDP 17109 Query: 506 ----------DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555 + ++ ++ + + P GG IL Y E++ VG+E W + E+ Sbjct: 17110 IAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWR-RANHTPES 17168 Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED- 614 E + GL+ TY R+ A+N G + + E + EP L+ M + Sbjct: 17169 CPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQ 17228 Query: 615 ----GNSIKVNLI 623 G++++++ I Sbjct: 17229 HIKVGDTLRLSAI 17241 Score = 59.3 bits (142), Expect = 1e-08 Identities = 103/461 (22%), Positives = 178/461 (38%), Gaps = 58/461 (12%) Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE---QDATI---------HLKV 304 EE+ + + S Q + K + + E + AEN+ GE + T+ L + Sbjct: 19925 EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDL 19984 Query: 305 FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364 P + Y+ + + L G P PS++W+ +++ D + V S Sbjct: 19985 KGLPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLAT-----DTRVSVESS 20034 Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVN 423 A ++L + Q +DAG+Y T N G ++ ++V P + GP+ + Sbjct: 20035 AVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMT 20094 Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA---SYLEVTPDSENDFGNYNCT 480 + +A P +L + N K SA + VT E + + Sbjct: 20095 LK---WAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVS 20151 Query: 481 AVNRIGQ-ESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532 A N+ G E L+ + A D P P+I V+ + + + +P+ TGG PI Sbjct: 20152 AENKYGVGEGLKSEPIVARHPFDVPDAPPPPNI--VDVRHDSVSLTWTDPKKTGGSPITG 20209 Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGI----VTIVGLKPETTYAVRLAALNGKGLGEIS 588 Y E++ +W K A+ I + GL Y R+ A+N G+G+ S Sbjct: 20210 YHLEFKERNSLLW-------KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS 20262 Query: 589 AASE--FKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRAL-SS 644 SE P+ P P++ + NS+ + + + DGG + Y+V R L S Sbjct: 20263 LPSEPVVALDPID-PPGKPEV---INITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSK 20318 Query: 645 EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685 W + + L +YE + A+N G A Sbjct: 20319 SWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISA 20359 Score = 59.3 bits (142), Expect = 1e-08 Identities = 86/399 (21%), Positives = 157/399 (39%), Gaps = 34/399 (8%) Query: 209 NVPPTIQARQNIVNATA-NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267 NVPP ++ + G+S+ + +G P P ++W KDG +IE+ + E +D Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---ITD 28009 Query: 268 --DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325 S+ L ++ ++ Y A+N +G A I +KV P + E++ Sbjct: 28010 VLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKM 28069 Query: 326 TLTCEAS-GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 TL +A D IT I E + ++ S T + + ++ Sbjct: 28070 TLWWDAPLNDGCAPITHYI----IEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFR 28125 Query: 385 CTASNTIG----QDSQSMYLEVQY-APKLQGPVAVYTWEGNQVNITCEVFAYP-----SA 434 +A N G DS + ++QY P G GN + +T +A P S Sbjct: 28126 VSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLT---WARPESDGGSE 28182 Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI- 493 + + + S+ + + S + +VT +E + ++ A N G I Sbjct: 28183 IQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGIS 28242 Query: 494 -LVQADTPSSPS-----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547 L++ P +P + + +T +++ +P GG+ I+ Y E WH Sbjct: 28243 RLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHK 28302 Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586 EA ++ T+ L+ Y R++A+NG G G+ Sbjct: 28303 V---NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGD 28338 Score = 58.9 bits (141), Expect = 2e-08 Identities = 83/339 (24%), Positives = 133/339 (39%), Gaps = 52/339 (15%) Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392 G P+P +W + ++I + T + S S LT+K DAGEY TA+N G Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQ-----ITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459 Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSN 449 + + + V P GPV + N++ E AT++W DG P + Sbjct: 20460 TKVEHVKVTVLDVPGPPGPVEI-------SNVSAE-----KATLTWTPPLEDGG-SPIKS 20506 Query: 450 YSNIKIYNTPSASYLEVTPDSEN--------DFGN---YNCTAVNRIGQ------ESLEF 492 Y ++ T + V+ D ++ GN + +AVN G+ E ++ Sbjct: 20507 YI-LEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKM 20565 Query: 493 I--LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550 + P P + V +TA V + P GG I Y E R E +W Sbjct: 20566 VDRFGPPGPPEKPEVSNVT--KNTATVSWKRPVDDGGSEITGYHVERR----EKKSLRWV 20619 Query: 551 DAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEG 609 A + + + + GL+ +TY R++A N G+G S AS+ P P Sbjct: 20620 RAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNP 20679 Query: 610 QMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSSE 645 + D +L DGG I Y+V ++ + E Sbjct: 20680 HV-TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717 Score = 58.5 bits (140), Expect = 2e-08 Identities = 70/334 (20%), Positives = 122/334 (36%), Gaps = 65/334 (19%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 GQ+ G P P W DG+QI + + I D + L I +D E+ Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530 Query: 288 IAENKAGEQDATIHLKVFA---KPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWR 342 +A+N+AG ++ L V A + K +VE + ++E ++ + A+G+P P I W Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590 Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ--SMYL 400 ++ I + + + ++L + S D+ Y TA N G+D+ + + Sbjct: 1591 KNSDIIVPHKYP---KIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647 Query: 401 EVQYAP-----KLQGPVAVY--------------------TWEGNQV------------- 422 EV++A KL P Y WE + Sbjct: 1648 EVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKK 1707 Query: 423 -------------NITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467 + C + P+ + W DG+ L ++N +++ N L+ Sbjct: 1708 KLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAAN--RLRMINEFGYCSLDYG 1765 Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501 D G C A N+ G + L+ D S Sbjct: 1766 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKS 1799 Score = 58.5 bits (140), Expect = 2e-08 Identities = 78/300 (26%), Positives = 120/300 (40%), Gaps = 25/300 (8%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G + + V P I+W + G L S I T S S L V + D G Y Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAI----IDTTESYSLLIVDKVNRYDAGKYT 29516 Query: 479 CTAVNRIGQESLEFILVQADTPS-SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 A N+ G++S ++ DTP PS+ E + + ++ P GG P+ Y E Sbjct: 29517 IEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEK 29576 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 R + + + + I GL T Y R+ N G+GE S+ Sbjct: 29577 REAAMRAFKT----VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSD--AVL 29630 Query: 598 VQGEPSAP-KLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVR-YRALSSEWKPEIRL 652 V P P KLE D V L + DGGS + Y++ +A + W + L Sbjct: 29631 VSEVPLVPAKLE---VVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTL 29687 Query: 653 -PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 711 P+ +H + SL+ +Y + A+N++G S+ V + Q + PT LST Sbjct: 29688 KPTVLEHT-VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV----LPTIDLST 29742 Score = 58.2 bits (139), Expect = 3e-08 Identities = 97/393 (24%), Positives = 162/393 (41%), Gaps = 55/393 (13%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 E + + G PIP+I W + +S+ + + ++S +SL++K D+G Sbjct: 22559 ESFKVDADIYGKPIPTIQWIKGDQELSNTAR-----LEIKSTDFATSLSVKDAVRVDSGN 22613 Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW--- 438 YI A N G+ S ++ ++V P +GPV + +T E T++W Sbjct: 22614 YILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI-------SGVTAE-----KCTLAWKPP 22661 Query: 439 FRDG-----QLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIG-QE 488 +DG + ++ ++ A+ +VT E + + AVN+ G E Sbjct: 22662 LQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGE 22721 Query: 489 SLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541 LE V A D P +P + V S V ++ P + GG IL Y E R Sbjct: 22722 PLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI--VVWERPASDGGSEILGYVLEKRDKE 22779 Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK--TQPV- 598 W K E + + GL Y R++A N GL E S S ++ P+ Sbjct: 22780 GIRWTR---CHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 22836 Query: 599 -QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALS-SEWKPEIRLPSG 655 G P+ PK+ + +S+ ++ K DGG I+ Y+V +S EW P+G Sbjct: 22837 KPGPPNNPKV---IDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEW-TMCTPPTG 22892 Query: 656 --SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686 ++ ++ L EY + A N+ G + A Sbjct: 22893 INKTNIEVEKLLEKHEYNFRICAINKAGVGEHA 22925 Score = 57.8 bits (138), Expect = 4e-08 Identities = 87/402 (21%), Positives = 152/402 (37%), Gaps = 40/402 (9%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 LT+ + +D G Y V+ DG ++ + +K + + + Q+ EG+ ++ + Sbjct: 2323 LTVKDVTKEDQGEYSFVI---DGKKTTCKLKMKP-RPIAILQGLSDQKVCEGD--IVQLE 2376 Query: 141 VVSSLPPTI-IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA--- 195 V SL +W G++V V ++ ++ L I + K D G Y L Sbjct: 2377 VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLST 2436 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 G ++ + VI + N++ T L C ++ W + EQI+ Sbjct: 2437 SGRVSVYSVDVITPLKDV-----NVIEGT-----KAVLECKVSVPDVTSVKWYLNDEQIK 2486 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + D + I +L I + +DE Y I G + +L V I + + Sbjct: 2487 PD-DRVQAIVKGTKQRLVINRTHASDEGPYKLIV----GRVETNCNLSVEKIKIIRGLRD 2541 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 T E + V E S I + W + I K + +H ++ LT+ ++ Sbjct: 2542 LTCTETQN-VVFEVELSHSGI-DVLWNFKDKEIKPSSK-----YKIEAHGKIYKLTVLNM 2594 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 D G+Y A + ++ P VA E + CEV A P + Sbjct: 2595 MKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVA----ESQEAVFECEV-ANPDSK 2649 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 W RDG+ LP +N NI+ + L + +D G Y Sbjct: 2650 GEWLRDGKHLPLTN--NIRSESDGHKRRLIIAATKLDDIGEY 2689 Score = 57.8 bits (138), Expect = 4e-08 Identities = 98/463 (21%), Positives = 195/463 (42%), Gaps = 64/463 (13%) Query: 35 ESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSS-TLTIYNANIDDAGI 93 ES F +++ D + + WF N ++L + SV D+ + ++T + +IDD Sbjct: 11944 ESAVFTVELSHD--NIRVKWFK-NDQRLHTTR---SVSMQDEGKTHSITFKDLSIDDTSQ 11997 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 + G SE++ TV + F E ++ ++ C++ + P + W Sbjct: 11998 IRVEAMGMS-SEAKLTV---LEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFK 12052 Query: 154 KGRDV------ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-GRILARGEINFKDIQV 206 G+++ ++K D + L ++ K+D G Y C+ G G+++ +D ++ Sbjct: 12053 DGKEIKPSKNAVIKADGK-----KRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREI 12107 Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE-KYIF 265 + P + + + + TA ++ + +W GE + Q D E K Sbjct: 12108 KLVRP--LHSVEVMETETARFETEISE-------DDIHANWKLKGEALLQTPDCEIKEEG 12158 Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QTAMELE 322 S L ++D+ ++ +A ++ HL+V KP++ + + Sbjct: 12159 KIHSLVLHNCRLDQTGGVDF------QAANVKSSAHLRV--KPRVIGLLRPLKDVTVTAG 12210 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 E T CE S + IP + W + + +K +V RS +V +LTL+ ++ DAGE Sbjct: 12211 ETATFDCELSYEDIP-VEWYLKGKKLEPSDK-----VVPRSEGKVHTLTLRDVKLEDAGE 12264 Query: 383 YICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 439 TA + + +++++ V++ L+ EG + CEV + +A + WF Sbjct: 12265 VQLTAKDF--KTHANLFVKEPPVEFTKPLEDQTVE---EGATAVLECEV-SRENAKVKWF 12318 Query: 440 RDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 ++G ++L S Y + + TP+ D Y C A Sbjct: 12319 KNGTEILKSKKYEIVADGRVRKLVIHDCTPE---DIKTYTCDA 12358 Score = 57.8 bits (138), Expect = 4e-08 Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 14/254 (5%) Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491 P I+W + L +IK +T ++L ++ D G Y T N G++ Sbjct: 19721 PPPKITWSKPNVNLRDRIGLDIK--STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYT 19778 Query: 492 FILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550 ++ DTP P ++ E +A V ++ P GG PI+ Y + R + W + Sbjct: 19779 IVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTT 19838 Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610 + + S + L+ +Y R+ A N G+G+ E + + P ++ + Sbjct: 19839 ECSKTSFR----VANLEEGKSYFFRVFAENEYGIGD---PGETRDAVKASQTPGPVVDLK 19891 Query: 611 M-GEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNA 668 + +S + K DGGS I Y+V + ++W+ ++ S S K L Sbjct: 19892 VRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGK 19949 Query: 669 EYEVYVVAENQQGK 682 EY V AEN+ G+ Sbjct: 19950 EYTFRVSAENENGE 19963 Score = 57.8 bits (138), Expect = 4e-08 Identities = 99/403 (24%), Positives = 159/403 (39%), Gaps = 62/403 (15%) Query: 213 TIQARQNIV-NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ 271 TI+A IV NA + LG+ P P SW+K G+ I + D + + SS Sbjct: 20389 TIKAGDTIVLNAISILGK-----------PLPKSSWSKAGKDI-RPSDITQITSTPTSSM 20436 Query: 272 LTIKKVDKNDEAEYICIAENKAG---EQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 LTIK + D EY A N G E L V P + N +A + T Sbjct: 20437 LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP 20496 Query: 329 CEASGDPIPS--ITWRTSTR---NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383 E G PI S + R ++R + SE+ ++S V++ ++ +Y + Sbjct: 20497 LEDGGSPIKSYILEKRETSRLLWTVVSED--------IQSCRHVATKLIQGNEYI----F 20544 Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--- 440 +A N G+ V+ + P E + V +AT+SW R Sbjct: 20545 RVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKN-------TATVSWKRPVD 20597 Query: 441 DG---------QLLPSSNYSNIKIYNTP-SASYLEVTPDSENDFGNYNCTAVNRIG---- 486 DG + + ++ TP S +VT E + +A NR G Sbjct: 20598 DGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPP 20657 Query: 487 QESLEFILVQ--ADTPSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543 E+ + +L++ A P PS V + +A + + +P GG+ I Y E + VG+E Sbjct: 20658 SEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717 Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586 W + +V L+ + Y R++A+N G+GE Sbjct: 20718 AWIKDTTGTALRITQFVVP--DLQTKEKYNFRISAINDAGVGE 20758 Score = 57.8 bits (138), Expect = 4e-08 Identities = 68/270 (25%), Positives = 99/270 (36%), Gaps = 12/270 (4%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G + I ++ P ISW +DG + + +I +T + + L V D G Y Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIISTDNHTLLTVKDCIRRDTGQYV 25861 Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535 T N G S+ D P P+ +E TA+ + + P+ GG I Y Sbjct: 25862 LTLKNVAGTRSVAVNCKVLDKPGPPA-GPLEINGLTAEKCSLSWGRPQEDGGADIDYYIV 25920 Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595 E R E H W + + L Y R+ +N G+GE + K Sbjct: 25921 EKR----ETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKA 25976 Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSS-EWKPEIRLP 653 PS P S+ + + + DGGS I Y++ R +S W + P Sbjct: 25977 LDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKP 26036 Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 V L EYE V AEN G S Sbjct: 26037 VYDLRVKSTGLREGCEYEYRVYAENAAGLS 26066 Score = 57.4 bits (137), Expect = 6e-08 Identities = 68/300 (22%), Positives = 117/300 (39%), Gaps = 25/300 (8%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE------- 471 G+Q+ I + P+ SW DG+ + +++ P + LE +S Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDG---VHDIPEDAQLETAENSSVIIIPEC 15881 Query: 472 --NDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGV 528 + G Y+ TA N+ GQ++ + D P P +V + + ++ + P+ GG Sbjct: 15882 KRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGD 15941 Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588 I Y E R + + W D + + L E Y R+ A N G+G Sbjct: 15942 RIKGYVIEKRTIDGKAWTKVNPDCGSTTF----VVPDLLSEQQYFFRVRAENRFGIGPPV 15997 Query: 589 AASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLIK-QDDGGSPIRHYLVRYRA----- 641 + T P P ++ ++G N++ ++ ++DGGSP+ HY+V A Sbjct: 15998 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTG 16057 Query: 642 -LSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 700 W+ + ++ L EYE V A N G SK + V Q +P Sbjct: 16058 TKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 16117 Score = 57.0 bits (136), Expect = 7e-08 Identities = 66/303 (21%), Positives = 115/303 (37%), Gaps = 13/303 (4%) Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479 N + I YP T +W ++L + + +K+ + + L ++P +D G Y Sbjct: 13410 NPITILVPSTGYPRPTATWCFGDKVLETGD--RVKMKTLSAYAELVISPSERSDKGIYTL 13467 Query: 480 TAVNRIGQESLEFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538 NR+ S E + PS+P + + + + ++ P+ GG P+ Y E R Sbjct: 13468 KLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKR 13527 Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598 V + W + T+ L Y ++ A N G GE + E Sbjct: 13528 EVSRKTWTKVMDFVTDLEF----TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST 13583 Query: 599 QGE-PSAPKLEGQMGEDGNSIKVNL-IKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGS 656 P P+ NSI + ++DGGS I+ Y+V S+ P Sbjct: 13584 PATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAE 13643 Query: 657 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVG 716 + + L+ Y V A N+QG SK + R + + A+ +P L + G Sbjct: 13644 TKMEVTGLEEGKWYAYRVKALNRQGASKPS----RPTEEIQAVDTQEAPEIFLDVKLLAG 13699 Query: 717 ILI 719 + + Sbjct: 13700 LTV 13702 Score = 56.6 bits (135), Expect = 9e-08 Identities = 88/424 (20%), Positives = 155/424 (36%), Gaps = 57/424 (13%) Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 G I AR EI+ + + I +V+A G++ L D G P P + W+KD Sbjct: 24694 GAITARDEIDAPNASLDPKYKDVI-----VVHA----GETFVLEADIRGKPIPDVVWSKD 24744 Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310 G+++E+ + + + L +K + D +YI N G + I +KV +P Sbjct: 24745 GKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPG- 24803 Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370 + +++ C + +P P + + E++ + V +L Sbjct: 24804 ---PPEGPLKVTGVTAEKCYLAWNP-PLQDGGANISHYIIEKRETSRLSWTQVSTEVQAL 24859 Query: 371 TLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAV---YTWEGNQVNIT 425 K + EYI A N G P GPV Y G Sbjct: 24860 NYKVTKLLPGNEYIFRVMAVNKYGIGE----------PLESGPVTACNPYKPPGPPSTPE 24909 Query: 426 CEVFAYPSATISWFR---------DGQLLPSSNYSNIK----IYNTPSASYLEVTPDSEN 472 S ++W R +G +L + ++ T + L VT +E Sbjct: 24910 VSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 24969 Query: 473 DFGNYNCTAVNR--IGQESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPE 523 + A N +G+ S + +A PS+P + + S+ + + +P Sbjct: 24970 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKV--TDTSRSSVSLAWSKPI 25027 Query: 524 ATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG-IVTIVGLKPETTYAVRLAALNGK 582 GG P+ Y E + + W + ++G T+ LK T Y R+ A+N + Sbjct: 25028 YDGGAPVKGYVVEVKEAAADEWTT---CTPPTGLQGKQFTVTKLKENTEYNFRICAINSE 25084 Query: 583 GLGE 586 G+GE Sbjct: 25085 GVGE 25088 Score = 56.6 bits (135), Expect = 9e-08 Identities = 94/398 (23%), Positives = 150/398 (37%), Gaps = 29/398 (7%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G SV L G P PT+ W KD +++ Q + D + + IK D+ + Y Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKEL-QTNALVCVENTTDLASILIKDADRLNSGCYEL 26945 Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347 N G ATI +++ KP + E++TL D + + + Sbjct: 26946 KLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGA---KITHYI 27002 Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIGQDSQSMYLEVQ 403 + E + +V H +T I EYI IG+ +S + + Sbjct: 27003 VEKRETSRVVWSMVSEHLEECIITTTKI--IKGNEYIFRVRAVNKYGIGEPLESDSVVAK 27060 Query: 404 YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI----KIYNTP 459 A GP + N V++ P A G L + ++ + T Sbjct: 27061 NAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETI 27120 Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILV--QADTPSSPS-IDQVEPYS 512 + +VT +EN Y AVN GQ E EF D P P+ I + Sbjct: 27121 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTK 27180 Query: 513 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 572 S+ + + +P GG + Y E R EE W + + + E +V+ LKP Y Sbjct: 27181 SSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVS--NLKPGVNY 27238 Query: 573 AVRLAALNGKGLGEISAASEFKTQPVQGEP--SAPKLE 608 R++A+N G GE +E PVQ + AP+++ Sbjct: 27239 YFRVSAVNCAGQGEPIEMNE----PVQAKDILEAPEID 27272 Score = 56.6 bits (135), Expect = 9e-08 Identities = 72/324 (22%), Positives = 121/324 (37%), Gaps = 44/324 (13%) Query: 22 VDIVPSQGEI--SVGESKF---FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDD 76 ++I P G+I +VGE ++C++ + ++W+ G + N ++ + + +D Sbjct: 31565 IEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYF--GVRQLENSEKYEITY-ED 31621 Query: 77 SSSTLTIYNANIDDAGIYKCVVT---GEDGSESEATVN---------VKIFQKLMFKNAP 124 + L + + D G Y+C V GED S +E V + K + + Sbjct: 31622 GVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTD 31681 Query: 125 T------PQEFR---------EGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-KKDVRFIV 168 T P EF GE+ + P + W G+ + D ++ Sbjct: 31682 TMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTF 31741 Query: 169 LSNN---YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA-----RQNI 220 S+ L I + D+ Y R + + V ++ PPT ++ + Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801 Query: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280 NA GQSV G P PT+ W KDG+ + + E D L I+ Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861 Query: 281 DEAEYICIAENKAGEQDATIHLKV 304 D Y A N AG HL+V Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885 Score = 56.6 bits (135), Expect = 9e-08 Identities = 77/402 (19%), Positives = 135/402 (33%), Gaps = 110/402 (27%) Query: 105 ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164 E T +K P EGE A CD PT+ W KG+ +L Sbjct: 32548 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ--VLSTSA 32605 Query: 165 RFIVLSNNY---LQIRGIKKTDEGTY-----RCEGRILARGEINFKDIQV---IVNVPPT 213 R V + Y +I ++ +DEG Y EG+ A + + +V V PP Sbjct: 32606 RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR 32665 Query: 214 IQARQNIVNATANLGQSVTL----------VCDAEGFPEPT------------------- 244 +++ + V + + + V E P PT Sbjct: 32666 VKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLK 32725 Query: 245 -----------------------MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281 ++W KDG+++++ + + +D + +L I + ++D Sbjct: 32726 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESD 32785 Query: 282 EAEYIC-----------------------------IAENKAGEQ---DATIHLK------ 303 + EY+C I+E K +Q ++T+ K Sbjct: 32786 QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP 32845 Query: 304 --VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV 361 + +KP I T + + +A+G+P P+ W + I T G + Sbjct: 32846 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-----TQGGKYKL 32900 Query: 362 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403 L + +D+G Y CT N+ G S S L ++ Sbjct: 32901 SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942 Score = 56.2 bits (134), Expect = 1e-07 Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 2/101 (1%) Query: 209 NVPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267 NVPP I + + T G +V L G P PT+SW KDG ++ E K Sbjct: 19290 NVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI-KMAMQR 19348 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 + L + V++ D +Y AEN +G + ATI LKV KP Sbjct: 19349 NLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389 Score = 56.2 bits (134), Expect = 1e-07 Identities = 63/291 (21%), Positives = 101/291 (34%), Gaps = 16/291 (5%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G + + P+ ++W +D +P + + +T + S L + D G+Y Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYV 22219 Query: 479 CTAVNRIGQ--ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536 N G+ E+L I++ P + + E + + + + P+ GG I Y E Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279 Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596 R W +++ LK Y R+AA N G + Q Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKAC----RLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQ 22335 Query: 597 ---PVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP 653 V G P P + D ++ N D G I ++L R S W + P Sbjct: 22336 YPFKVPGPPGTPVVT-LSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTP 22394 Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRTSAQPTAIP 700 L+ EYE V AEN G K + +V R P P Sbjct: 22395 IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRP 22445 Score = 56.2 bits (134), Expect = 1e-07 Identities = 66/275 (24%), Positives = 106/275 (38%), Gaps = 24/275 (8%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G V + + P+ TI W++D + L ++ + + + NT + + + + G Y Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYE 26944 Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535 N +G S + D P P +E + TA+ + + P GG I Y Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPG-GPIEFKTVTAEKITLLWRPPADDGGAKITHYIV 27003 Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE------ISA 589 E R VW E E I+T + Y R+ A+N G+GE + A Sbjct: 27004 EKRETSRVVWSM----VSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059 Query: 590 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWK 647 + F T G P K+ NS+ V + DGGS I Y + R S W Sbjct: 27060 KNAFVTPGPPGIPEVTKI------TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWF 27113 Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 682 ++ + L N++Y+ V A N G+ Sbjct: 27114 KVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQ 27148 Score = 55.8 bits (133), Expect = 2e-07 Identities = 123/602 (20%), Positives = 219/602 (36%), Gaps = 93/602 (15%) Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL---SNNYLQIRGIKKTDEGT 186 + GED ++ PPT+ W+ ++ L D R+ + S++ L I + + D G Sbjct: 27284 KAGEDVQVLIPFKGRPPPTVTWRKDEKN--LGSDARYSIENTDSSSLLTIPQVTRNDTGK 27341 Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPT 244 Y + G K V V V T A Q + + G +VTL+ D P Sbjct: 27342 YILT---IENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRG-TVTLLWDPPLIDGGSPI 27397 Query: 245 MSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQDATI 300 +++ IE+ + ++ + S S + K +D +++ + +AEN+ G Sbjct: 27398 INYV-----IEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIG------ 27446 Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN---ISSEEKTLDG 357 +P T E A E+ PI ++ + ST+ +S + DG Sbjct: 27447 ----IGEPCET-TEPVKAAEVPA-----------PIRDLSMKDSTKTSVILSWTKPDFDG 27490 Query: 358 HMVVR--------------SHARVSS---LTLKSIQYTDAGEYICTASN--------TIG 392 V+ SHA +S + + ++ E+ A N TIG Sbjct: 27491 GSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIG 27550 Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451 + + P A T G+ V++ P +ISW +DG L S + Sbjct: 27551 PITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEF- 27609 Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQ 507 ++ T + L + + G Y N + + ++ ++ PS P D+ Sbjct: 27610 -VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDE 27668 Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567 ++ + + + +D PE GG I Y E R + W + + + L Sbjct: 27669 IK--ADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFK----VPNLV 27722 Query: 568 PETTYAVRLAALNGKGLGE------ISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVN 621 + Y R+ A N G+ + I A +F+ + G P P + + DG S+ + Sbjct: 27723 KDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFR---IPGPPGKPVIY-NVTSDGMSLTWD 27778 Query: 622 LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681 D G ++ + S W+ P L +Y+ V AEN G Sbjct: 27779 APVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAG 27838 Query: 682 KS 683 S Sbjct: 27839 LS 27840 Score = 55.5 bits (132), Expect = 2e-07 Identities = 115/520 (22%), Positives = 194/520 (37%), Gaps = 56/520 (10%) Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 G I KD + + + R IV N G++ L D G P PT+ W + ++IE+ Sbjct: 23612 GPITAKDEVELPRISMDPKFRDTIV---VNAGETFRLEADVHGKPLPTIEWLRGDKEIEE 23668 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 E +D + L +K + D +YI A N AG + +++KV +P Q Sbjct: 23669 SARCE-IKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQ 23727 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 E+ +LT P+ S + E + VV S +S LK + Sbjct: 23728 VTGVTSEKCSLTW---SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS--LKVTK 23782 Query: 377 YTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434 + EY+ A N G ++ AP L V + +T A S Sbjct: 23783 LLEGNEYVFRIMAVNKYGVGE-----PLESAPVLMKNPFVLPGPPKSLEVT--NIAKDSM 23835 Query: 435 TISWFRD---------GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTA 481 T+ W R G ++ + S I+ L VT +E+ + +A Sbjct: 23836 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 23895 Query: 482 VNR--IGQESLEFILVQADTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534 N +G+ S + +A P + V+ ++ + + +P GG IL Y Sbjct: 23896 ENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYV 23955 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594 E EE W + + I L Y +R+ ALN GLGE A S Sbjct: 23956 VEICKADEEEW--QIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE--ATSVPG 24011 Query: 595 TQPVQGEPSAPKLE-------GQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWK 647 T + + AP+L+ G + G S ++++ + G P + + E+ Sbjct: 24012 TVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFK---GRPTPE--ITWSREEGEFT 24066 Query: 648 PEIRLPSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKA 685 ++++ G ++ L + D N + + EN G A Sbjct: 24067 DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSA 24106 Score = 55.1 bits (131), Expect = 3e-07 Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 14/133 (10%) Query: 190 EGRILARGEINFKDIQVIVNV-------PPTIQARQNIVNATANL--GQSVTLVCDAEGF 240 E R+ A EI + + +NV PPTI+ R ++ T + G+ V + D G Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 15425 Query: 241 PEPTMSWTKDGEQIEQEED-----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295 P P + W+K+ IE+ D E+ S+ ++L+I K + D+ Y A N+ G Sbjct: 15426 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485 Query: 296 QDATIHLKVFAKP 308 +H++V+ +P Sbjct: 15486 VFRNVHVEVYDRP 15498 Score = 55.1 bits (131), Expect = 3e-07 Identities = 80/363 (22%), Positives = 138/363 (38%), Gaps = 27/363 (7%) Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPKLQGPVAVYTW 417 V H + + T++ + E+ A N G + ++ + P+++ P A T Sbjct: 28593 VEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE-PTADLTG 28651 Query: 418 EGNQVNITCE----------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467 NQ+ ITC+ + P+ ++W + L ++ + I T + L V Sbjct: 28652 ITNQL-ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETD--RVSITTTKDRTTLTVK 28708 Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEA 524 D G Y T N G ++ +V P P +E S +A+ + + EP+ Sbjct: 28709 DSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG-PVTGPIEVSSVSAESCVLSWGEPKD 28767 Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGL 584 GG I Y E R G W K + + L Y+ R+++ N G+ Sbjct: 28768 GGGTEITNYIVEKRESGTTAWQLVNSSVKRTQ----IKVTHLTKYMEYSFRVSSENRFGV 28823 Query: 585 GEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALS 643 + ++ + PSAP N++ + + DGGS I Y V + + Sbjct: 28824 SKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERN 28883 Query: 644 S-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702 + W E ++P + + L EY+ A N G SKA+ AQ + A Sbjct: 28884 TILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ-NPVDAP 28942 Query: 703 GSP 705 G P Sbjct: 28943 GRP 28945 Score = 54.7 bits (130), Expect = 4e-07 Identities = 72/339 (21%), Positives = 127/339 (37%), Gaps = 20/339 (5%) Query: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305 +W KDG I +E ++I +L I V +D EY C+ E+ +T L V Sbjct: 11150 TWMKDGSNI-RESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208 Query: 306 AKPK--ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363 P + +E + + + + L+CE + + + WR + + + G +V Sbjct: 11209 ELPVRFVKTLEEEVTVVKGQPLYLSCELNKE--RDVVWRKDGKIVVEK----PGRIVPGV 11262 Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQV 422 + +LT+ TDAG Y T N + S V+ L P+ + Sbjct: 11263 IGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGT 11322 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 I A + I WF+ +P+ +I + YL++ D Y AV Sbjct: 11323 AIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY---AV 11379 Query: 483 NRIGQE-SLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541 G+ + L + + I+ V Y + FD + +P +W+ G Sbjct: 11380 EIEGKRYPAKLTLGEREVELLKPIEDVTIYEKES-ASFDAEISEADIP-----GQWKLKG 11433 Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580 E + S + K + +T+ +K + V ALN Sbjct: 11434 ELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALN 11472 Score = 54.7 bits (130), Expect = 4e-07 Identities = 62/306 (20%), Positives = 122/306 (39%), Gaps = 36/306 (11%) Query: 16 TAVSLQVDIVPSQGEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVW 73 T +++D +++V E + F C + +A ++ W G + + + ++ Sbjct: 11480 TVKEIELDFAVPLKDVTVPERRQARFECVLTREA---NVIW--SKGPDIIKSSDKFDII- 11533 Query: 74 NDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGE 133 D L I ++ DD G+Y V G+ S ++ L F + Q +EGE Sbjct: 11534 ADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGE 11589 Query: 134 DAVIVCDVVSSLPPTIIWK-----HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYR 188 A VC++ + +K H R V++ + + + L+++ + D + Sbjct: 11590 TATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK-----THKLEMKEVTLDDISQIK 11644 Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248 + + E++ ++ P + + + TA +TL C+ + + W Sbjct: 11645 AQVK-----ELSSTAQLKVLEADPYFTVKLH--DKTAVEKDEITLKCEVS--KDVPVKWF 11695 Query: 249 KDGEQIEQEEDDEKYIFSDDSSQ--LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306 KDGE+I KY D + L IKK D D+ EY+C + + T+ ++ Sbjct: 11696 KDGEEIVPSP---KYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIK 11752 Query: 307 KPKITY 312 K Y Sbjct: 11753 VEKPLY 11758 Score = 54.7 bits (130), Expect = 4e-07 Identities = 70/287 (24%), Positives = 108/287 (37%), Gaps = 14/287 (4%) Query: 405 APKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460 APK++ V V G + +V P T+ W +DG+ L + IKI Sbjct: 21458 APKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKI--ADF 21515 Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQ 518 ++ L + D G Y TA N G F + D P P + E S + Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLS 21575 Query: 519 FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAA 578 + P GG I Y + R W + + + ++ + L Y R+ A Sbjct: 21576 WFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLK----VTKLLKGNEYIFRVMA 21631 Query: 579 LNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLV 637 +N G+GE + G P PK +S+ V D DGGS I +Y+V Sbjct: 21632 VNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIV 21691 Query: 638 RYRALSSEWKPEIRLPSGSD-HVMLKSLDWNAEYEVYVVAENQQGKS 683 R + + + + +D + L EYE ++AEN G S Sbjct: 21692 ERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGIS 21738 Score = 54.7 bits (130), Expect = 4e-07 Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%) Query: 419 GNQVNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--DFG 475 G + + + P+ + W + DG++ ++ ++S+ + D+ N D G Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID-------VTSSFTSLVLDNVNRYDSG 23009 Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534 Y T N G +S + DTPS P ++ E + + ++ P GG I Y Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 23069 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG-EISAASEF 593 E R + + + + + S + I L+ +Y R+ A N G+G A Sbjct: 23070 VEKREATRKSYAAVVTNCHKNSWK----IDQLQEGCSYYFRVTAENEYGIGLPAQTADPI 23125 Query: 594 KTQPVQGEPSAPKLEGQMGEDG---NSIKVNLIKQD-DGGSPIRHYLVRYRALSSE-WKP 648 K V P+ G++ D NS+ ++ K + DGGS I Y+V +A SE W Sbjct: 23126 KVAEV------PQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE 23179 Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 R+ S ++ +L EY VVA N++G+S Sbjct: 23180 CARVK--SLQAVITNLTQGEEYLFRVVAVNEKGRS 23212 Score = 54.3 bits (129), Expect = 5e-07 Identities = 59/230 (25%), Positives = 95/230 (41%), Gaps = 16/230 (6%) Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQFD 520 ++L + + +D G Y+ T VN G++++ + DTP S +V + T+ V + Sbjct: 18661 AFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWA 18720 Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580 PE GG + Y E R + W + + K+ S + L P Y R+ A+N Sbjct: 18721 PPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFH----VTNLVPGNEYYFRVTAVN 18776 Query: 581 --GKGLGEISAASEFKTQPVQGEPSAP-KLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV 637 G G+ + P+ EP P KLE ++ L DGG+ I Y+ Sbjct: 18777 EYGPGVPTDVPKPVLASDPL-SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYIT 18835 Query: 638 RYRALSSEWKPEIRLPSGSD----HVMLKSLDWNAEYEVYVVAENQQGKS 683 YR E +P R S +++ L +Y+ V A N G S Sbjct: 18836 SYR---EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 18882 Score = 54.3 bits (129), Expect = 5e-07 Identities = 125/579 (21%), Positives = 212/579 (36%), Gaps = 75/579 (12%) Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV 206 P ++W D+ + V S L I + D G Y + + ++ + + Sbjct: 26216 PNVLWSKPDTDLRTRAYVD-TTDSRTSLTIENANRNDSGKYT----LTIQNVLSAASLTL 26270 Query: 207 IVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261 +V V PPT Q++ +A L V PE IE+ E + Sbjct: 26271 VVKVLDTPGPPTNITVQDVTKESAVLSWDV---------PENDGGAPVKNYHIEKREASK 26321 Query: 262 KYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 K S ++ ++L+ K + + A Y +GE + + + K + E + Sbjct: 26322 KAWVSVTNNCNRLSYKVTNLQEGAIYYF---RVSGENEFGVGIPAETKEGVKITEKPSP- 26377 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-----VSSLTLKS 374 E++ +T S D + S+TW + S H VV + + V KS Sbjct: 26378 --PEKLGVT-SISKDSV-SLTWLKPEHDGGSRIV----HYVVEALEKGQKNWVKCAVAKS 26429 Query: 375 IQYTDAG-----EYICT--ASNTIG-QDSQSMYLEVQYAPKLQGPV---------AVYTW 417 + +G EY A N G D + + L V +L+ P VY Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVR 26489 Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 G+ + + + P ++ RDG L ++ N +I T + + D G Y Sbjct: 26490 AGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI--TAENLTINLKESVTADAGRY 26547 Query: 478 NCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKY 533 TA N G +V D P P+ I + S T ++++ P+ GG + Y Sbjct: 26548 EITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVT--LKWEPPKYDGGSQVTNY 26605 Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASE 592 R VW + ++ ++ L Y R+ A N G+ + I +A Sbjct: 26606 ILLKRETSTAVWT----EVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACV 26661 Query: 593 FKTQP--VQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSSE-WKP 648 P G PS P + E SI V + +GGS + Y + + +S W+ Sbjct: 26662 TVKLPYTTPGPPSTPWVTNVTRE---SITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQK 26718 Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH 687 +L + H + ++ YE V AEN G K +H Sbjct: 26719 ANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSH 26757 Score = 53.9 bits (128), Expect = 6e-07 Identities = 87/379 (22%), Positives = 147/379 (38%), Gaps = 35/379 (9%) Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 V L SG P P+I W + + + + + V + ++S+ +K ++G Y Sbjct: 26890 VKLRAGISGKPAPTIEWYKDDKELQT-----NALVCVENTTDLASILIKDADRLNSGCYE 26944 Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443 N +G S ++ +++ P G P+ T ++ + P A + Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWR----PPADDGGAKITH 27000 Query: 444 LLPSSNYSNIKIYNTPSASYLE-VTPDSENDFGN---YNCTAVNRIG-QESLEFILVQAD 498 + ++ +++ S E + ++ GN + AVN+ G E LE V A Sbjct: 27001 YIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAK 27060 Query: 499 ----TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553 TP P I +V + + V + P A GG I Y E R W K Sbjct: 27061 NAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKV---LK 27117 Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE 613 E + + GL + Y R+ A+N G G S SEF +P P + ++ + Sbjct: 27118 ETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIAD 27177 Query: 614 D-GNSIKVNLIKQ-DDGGSPIRHYLVRYR-ALSSEW-----KPEIRLPSGSDHVMLKSLD 665 +SI + K DGGS + Y+V R EW K E+R + ++ +L Sbjct: 27178 STKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR----TTEYVVSNLK 27233 Query: 666 WNAEYEVYVVAENQQGKSK 684 Y V A N G+ + Sbjct: 27234 PGVNYYFRVSAVNCAGQGE 27252 Score = 53.9 bits (128), Expect = 6e-07 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 9/113 (7%) Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 + KDI + + R +++ A G+ V ++ +G P PT++W KD + + Sbjct: 27260 VQAKDILEAPEIDLDVALRTSVI---AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGS-- 27314 Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKP 308 D +Y +D SS LTI +V +ND +YI EN GE + +T+ +KV P Sbjct: 27315 -DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTP 27366 Score = 53.9 bits (128), Expect = 6e-07 Identities = 85/368 (23%), Positives = 135/368 (36%), Gaps = 64/368 (17%) Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE------- 322 ++ T+ + +E ++ A N AG+ D+ I V+ TA EL+ Sbjct: 28311 TRYTVTDLQAGEEYKFRVSAINGAGKGDSCE-----VTGTIKAVDRLTAPELDIDANFKQ 28365 Query: 323 -------EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 + L G P P+ W N+S + + S+LT+++ Sbjct: 28366 THVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD-------IHTTDSFSTLTVENC 28418 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 DAG+Y T N G S + ++V P GP IT + SAT Sbjct: 28419 NRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP------------ITFKDVTRGSAT 28466 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE---------NDFGN-----YNCTA 481 + W D LL + + AS SE ND + +A Sbjct: 28467 LMW--DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSA 28524 Query: 482 VNRIG---QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 VN G + +V + P+ P +D V+ S+A + + +P+ GG I Y E Sbjct: 28525 VNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM 28584 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596 R G + W + + + T+ L +T Y R+ A N G E A S + Sbjct: 28585 RQKGSDFWVEAGH-----TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIK 28639 Query: 597 PVQGEPSA 604 Q EP+A Sbjct: 28640 EPQIEPTA 28647 Score = 53.5 bits (127), Expect = 8e-07 Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 1/81 (1%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G+ + + D G P P +SW KDG +IE+ E I +D+ + LT+K + D +Y+ Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTE-IISTDNHTLLTVKDCIRRDTGQYVL 25862 Query: 288 IAENKAGEQDATIHLKVFAKP 308 +N AG + ++ KV KP Sbjct: 25863 TLKNVAGTRSVAVNCKVLDKP 25883 Score = 52.8 bits (125), Expect = 1e-06 Identities = 101/457 (22%), Positives = 175/457 (38%), Gaps = 65/457 (14%) Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-----KPKITYVE--NQTAMEL 321 S + T+K + + D EY A N G+ + K P +++ ++ + + Sbjct: 16773 SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRV 16832 Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK----SIQY 377 E LT SG P P ++W ++ +++T H + + TL + Sbjct: 16833 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRT---------HIKTTPATLALEKIKAKR 16883 Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437 +D+G+Y N+ G S+ + +V + PV +++ +T + IS Sbjct: 16884 SDSGKYCVVVENSTG--SRKGFCQVNVVDRPGPPVGPVSFD----EVTKDYMV-----IS 16932 Query: 438 W---FRDGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNR 484 W DG +NY K + + + + +V+ E + A N Sbjct: 16933 WKPPLDDGGS-KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENL 16991 Query: 485 IG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536 G + L ++A D P P + +V +A V +++P GG PI Y E Sbjct: 16992 YGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVT--KDSALVTWNKPH-DGGKPITNYILE 17048 Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE--FK 594 R + W D + + L Y R++A N G+G+ S S+ F Sbjct: 17049 KRETMSKRWARVTKDPIHPYTK--FRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFA 17106 Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRAL-SSEWKPEIRL 652 P+ +PS P + NS+ + + DGGS I Y+V Y+ + EW+ Sbjct: 17107 KDPI-AKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHT 17165 Query: 653 PSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKAAH 687 P K L Y+ V+A N G+S AH Sbjct: 17166 PESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202 Score = 52.0 bits (123), Expect = 2e-06 Identities = 111/483 (22%), Positives = 179/483 (37%), Gaps = 61/483 (12%) Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210 W R L+ + + YL R + ++G R + R LA I KD+ + +V Sbjct: 23177 WSECARVKSLQAVITNLTQGEEYL-FRVVAVNEKG--RSDPRSLAV-PIVAKDLVIEPDV 23232 Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270 P + + +GQ + + G P+PT++WTKDG ++Q S D + Sbjct: 23233 KPAFSSY------SVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ-TTRINVTDSLDLT 23285 Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330 L+IK+ K+D +Y N G++ A+I + KP + E +TL Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL--- 23342 Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTAS 388 S +P P T N +++ + A V+ TLK + EY A Sbjct: 23343 -SWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAE 23400 Query: 389 NTIGQD--SQSMYLEVQYAPKLQGPVA------------VYTWEGNQVNITCEVFAY--- 431 N GQ +S + QY K GP V W N V Y Sbjct: 23401 NRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLE 23460 Query: 432 --PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 +I W + + + + + K N E +EN G V + + S Sbjct: 23461 RKERNSILWTKVNKTI--IHDTQFKAQNLEEGIEYEFRVYAENIVG------VGKASKNS 23512 Query: 490 LEFILVQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548 ++ D P +P V+ T +Q+ +P GG I Y E R + + + Sbjct: 23513 ECYVARDPCDPPGTPEPIMVKRNEIT--LQWTKPVYDGGSMITGYIVEKRDLPD----GR 23566 Query: 549 WYDAKEAS-MEGIVTIVGLKPETTYAVRLAALNGKG--------LGEISAASEFKTQPVQ 599 W A + +E T+ GL + Y R+ A N G G I+A E + + Sbjct: 23567 WMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRIS 23626 Query: 600 GEP 602 +P Sbjct: 23627 MDP 23629 Score = 51.2 bits (121), Expect = 4e-06 Identities = 47/182 (25%), Positives = 83/182 (45%), Gaps = 13/182 (7%) Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK---DVRFIVLSNNY-LQIRGIKKTDEGT 186 +G ++ V P T W +D ++++ V ++ N Y +I+ EG Sbjct: 17830 DGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEG- 17888 Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMS 246 E R LA I KDI V + R I T +GQ++ ++ +G PEP ++ Sbjct: 17889 ---EPRELAESVIA-KDILHPPEVELDVTCRDVI---TVRVGQTIRILARVKGRPEPDIT 17941 Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306 WTK+G+ + +E+ + I +L IK+ + D +YI A+N +G + + V Sbjct: 17942 WTKEGKVLVREKRVD-LIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLD 18000 Query: 307 KP 308 +P Sbjct: 18001 RP 18002 Score = 50.8 bits (120), Expect = 5e-06 Identities = 47/205 (22%), Positives = 89/205 (43%), Gaps = 13/205 (6%) Query: 405 APKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY 463 AP P+ +V EG+ + +P +SWFRDGQ++ +S ++I + + Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64 Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSIDQVEPYS--STAQVQFD 520 L + ++ + G Y+ A N GQ S +LV+A+T + +++ + +QV+ Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124 Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580 P++K+ + G E+ S + + + I PE + + A N Sbjct: 125 VRVTGIPTPVVKFYRD----GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180 Query: 581 GKGLGEISAASEFKTQPVQGEPSAP 605 +G ++ +E VQGE P Sbjct: 181 --SVGRATSTAELL---VQGEEEVP 200 Score = 50.4 bits (119), Expect = 7e-06 Identities = 108/509 (21%), Positives = 181/509 (35%), Gaps = 50/509 (9%) Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 I KD V ++ R IV + G + ++ G P PT++W + + QE Sbjct: 16513 IEMKDRLVSPDLQLDASVRDRIV---VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEA 16569 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 E S S + IK ++ + Y +A+N+AGE+ TI + V P Sbjct: 16570 TIETTAIS---SSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAH 16626 Query: 319 MELEEQVTLTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 E LT + D P + R T + V R +A V L Sbjct: 16627 NLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAY 16686 Query: 377 YTDAGEYICTASNTIG-----QDSQSMYL-EVQYAPKLQGPVAVYTWEGNQVNITCEVFA 430 + + A N+IG + S+++ + E P+ + V N V +T Sbjct: 16687 F-----FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPK 16741 Query: 431 YP--SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 Y S I++ + +L+ + + + N S Y V E D Y +AVN +GQ Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKY-TVKGLKEGDTYEYRVSAVNIVGQG 16800 Query: 489 SLEFI---LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545 F + D + P++ + ++ E A G R G+ Sbjct: 16801 KPSFCTKPITCKDELAPPTLHL--DFRDKLTIRVGEAFALTG----------RYSGKPKP 16848 Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL---NGK-------GLGEISAASEFKT 595 W+ + +E T + P T ++ A +GK G + Sbjct: 16849 KVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 16908 Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPS 654 G P P ++ +D I DDGGS I +Y++ + + + W P + S Sbjct: 16909 VDRPGPPVGPVSFDEVTKDYMVISWK-PPLDDGGSKITNYIIEKKEVGKDVWMP-VTSAS 16966 Query: 655 GSDHVMLKSLDWNAEYEVYVVAENQQGKS 683 + L +Y + AEN G S Sbjct: 16967 AKTTCKVSKLLEGKDYIFRIHAENLYGIS 16995 Score = 49.7 bits (117), Expect = 1e-05 Identities = 91/375 (24%), Positives = 141/375 (37%), Gaps = 58/375 (15%) Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140 LT+ N DD G Y GE+ + + TV K + T Q E ++AV C+ Sbjct: 2589 LTVLNMMKDDEGKYT-FYAGENMTSGKLTVAGGAISKPL-----TDQTVAESQEAVFECE 2642 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200 V + W G+ + L ++R + I K D+ GE Sbjct: 2643 VANP-DSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDD-----------IGEYT 2690 Query: 201 FKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 +K + ++A ++ + N T Q + + W K+G +E Sbjct: 2691 YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLES- 2749 Query: 258 EDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHL-----KVFAKPK- 309 +EKY S + L IK DE+ Y + G A+ L K+ KPK Sbjct: 2750 --NEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVETVKIIKKPKD 2803 Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369 +T +EN T V S D +P + W S E K D H +V S +V Sbjct: 2804 VTALENAT-------VAFEVSVSHDTVP-VKWFHK----SVEIKPSDKHRLV-SERKVHK 2850 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEV- 428 L L++I +DAGEY + +++E + K + V E + CEV Sbjct: 2851 LMLQNISPSDAGEYTAVVGQL--ECKAKLFVETLHITKTMKNIEVP--ETKTASFECEVS 2906 Query: 429 -FAYPSATISWFRDG 442 F PS W ++G Sbjct: 2907 HFNVPS---MWLKNG 2918 Score = 49.7 bits (117), Expect = 1e-05 Identities = 102/466 (21%), Positives = 168/466 (36%), Gaps = 28/466 (6%) Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290 +T++ + G+P PT +W G+++ + D K ++L I +++D+ Y E Sbjct: 13412 ITILVPSTGYPRPTATWC-FGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLE 13470 Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP--IPSITWRTSTRNI 348 N+ I + V A+P E + ++ V LT E D P + R + Sbjct: 13471 NRVKTISGEIDVNVIARPSAP-KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREV 13529 Query: 349 SSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY---LEVQYA 405 S + T V V L +Q + +C A N G + + + Sbjct: 13530 SRKTWTKVMDFVTDLEFTVPDL----VQGKEYLFKVC-ARNKCGPGEPAYVDEPVNMSTP 13584 Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL---PSSNYSNIKIYNTPSAS 462 + P W N + P G ++ P + + + + Sbjct: 13585 ATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAET 13644 Query: 463 YLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQA-DTPSSPSI----DQVEPYSSTA 515 +EVT E + Y A+NR G + S +QA DT +P I + + A Sbjct: 13645 KMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKA 13704 Query: 516 QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVR 575 + + P G P + K W + K + + VTIV K T Sbjct: 13705 GTKIELPATVTGKP--EPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI 13762 Query: 576 LAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHY 635 + A+N G +A E G P+A + E + + +DDGGS I +Y Sbjct: 13763 IEAVN--VCGRATAVVEVNVLDKPGPPAAFDITDVTNE--SCLLTWNPPRDDGGSKITNY 13818 Query: 636 LVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681 +V RA SE ++ + L N EY V AEN G Sbjct: 13819 VVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYG 13864 Score = 49.3 bits (116), Expect = 2e-05 Identities = 96/438 (21%), Positives = 165/438 (37%), Gaps = 35/438 (7%) Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82 DI+ ++ E VG S F C V+ I+ + +G + + + + D L Sbjct: 11123 DIILTESEF-VGSSAIFECLVSPSTA---ITTWMKDGSNIRESPKHRFIA--DGKDRKLH 11176 Query: 83 IYNANIDDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141 I + + DAG Y CV+ G S A + V+ K +G+ + C++ Sbjct: 11177 IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL 11236 Query: 142 VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199 + ++W+ G+ V+ K + V ++ L I TD GTY + Sbjct: 11237 --NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTY-----TVTVENA 11289 Query: 200 NFKDIQVIVNVPPTIQ--ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 N + V V I+ + I + + CD P + W K ++I E Sbjct: 11290 NNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAE 11348 Query: 258 EDDEKYIFSDDSS-QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 +D+ I D + L IK D AEY E K A + L + +E+ Sbjct: 11349 PNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGK--RYPAKLTLGEREVELLKPIEDV 11406 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 T E +E + E S IP W+ + E +++ LTL ++ Sbjct: 11407 TIYE-KESASFDAEISEADIPG-QWK-----LKGELLRPSPTCEIKAEGGKRFLTLHKVK 11459 Query: 377 YTDAGEYICTASNTIGQDSQSM-YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 AGE + A N I ++ +E+ +A L+ V E Q C + A Sbjct: 11460 LDQAGEVLYQALNAITTAILTVKEIELDFAVPLKD---VTVPERRQARFECVLTR--EAN 11514 Query: 436 ISWFRDGQLLPSSNYSNI 453 + W + ++ SS+ +I Sbjct: 11515 VIWSKGPDIIKSSDKFDI 11532 Score = 48.5 bits (114), Expect = 3e-05 Identities = 66/279 (23%), Positives = 108/279 (38%), Gaps = 44/279 (15%) Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 T+T G P+P++ W S + L V + +SLT+++ D+G+Y Sbjct: 26205 TMTVPFRGRPVPNVLW-------SKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257 Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDG 442 T N + S ++ ++V P G NIT + SA +SW DG Sbjct: 26258 TIQNVLSAASLTLVVKVLDTP------------GPPTNITVQDVTKESAVLSWDVPENDG 26305 Query: 443 QLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488 P NY + + + N + +VT E + + N G E Sbjct: 26306 G-APVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAE 26364 Query: 489 SLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547 + E + + + PS P V S + + + +PE GG I+ Y E G++ W Sbjct: 26365 TKEGVKI-TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNW-V 26422 Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586 K AK + GL+ + Y R+ A N GL + Sbjct: 26423 KCAVAKSTHH----VVSGLRENSEYFFRVFAENQAGLSD 26457 Score = 47.8 bits (112), Expect = 4e-05 Identities = 75/343 (21%), Positives = 138/343 (40%), Gaps = 32/343 (9%) Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320 E+ + D L ++ V+ +E I+EN + KP I + + Sbjct: 14347 EEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPD-------CKPTIDLETHDIIVI 14399 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380 E++++ P+P+++W + + + ++ + + +H V KS++ DA Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP----KSVR-ADA 14454 Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT--ISW 438 G Y T N +G + S+ ++V P + + +T E + T + + Sbjct: 14455 GIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHY 14514 Query: 439 FRDGQLLPSSNYSNIKI-YNTPSASYLEVTPDSENDFGNYNCTAVNRI-GQESLEF---- 492 + + Y + N S + ++ P+ E F AVN++ G E +E Sbjct: 14515 VLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFF---RVKAVNKVGGGEYIELKNPV 14571 Query: 493 ILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549 I P P +D VE ++ TA+ + + P GG I+ Y E A GEE +W Sbjct: 14572 IAQDPKQPPDPPVD-VEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEE----RW 14626 Query: 550 YDAKEASMEGIV-TIVGLKPETTYAVRLAALNGKGLGEISAAS 591 E + + T GL+ Y R+ A N G+ E S A+ Sbjct: 14627 KRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRAT 14669 Score = 47.8 bits (112), Expect = 4e-05 Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 10/118 (8%) Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250 G I AR E++ I + TI +V+A G+S + D G P PT+ W K Sbjct: 22530 GAITARDEVDPPRISMDPKYKDTI-----VVHA----GESFKVDADIYGKPIPTIQWIKG 22580 Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 +++ E +D ++ L++K + D YI A+N AGE+ T+++KV +P Sbjct: 22581 DQELSNTARLE-IKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637 Score = 47.8 bits (112), Expect = 4e-05 Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 3/85 (3%) Query: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283 T G S+ L+ G P P ++W+K G + + ++ S L + KV++ D Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT---TESYSLLIVDKVNRYDAG 29513 Query: 284 EYICIAENKAGEQDATIHLKVFAKP 308 +Y AEN++G++ AT+ +KV+ P Sbjct: 29514 KYTIEAENQSGKKSATVLVKVYDTP 29538 Score = 47.4 bits (111), Expect = 6e-05 Identities = 69/332 (20%), Positives = 136/332 (40%), Gaps = 31/332 (9%) Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVT 326 + + + ++K+ + E + A NKAG + A + + + K+ + +EL + + Sbjct: 22894 NKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIIN 22953 Query: 327 LTCEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 + S G P P + W I ++ + +SL L ++ Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAA-------IIDVTSSFTSLVLDNVNRY 23006 Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE--VFAYPSATI 436 D+G+Y T N+ G S + + V P + V + V+IT E + S Sbjct: 23007 DSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEF 492 ++ + + +Y+ + + N S+ ++ E + TA N G ++ + Sbjct: 23067 NYIVEKREATRKSYAAV-VTNCHKNSW-KIDQLQEGCSYYFRVTAENEYGIGLPAQTADP 23124 Query: 493 ILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 551 I V A+ P P V+ + ++ + + +PE GG I++Y E +A E W Sbjct: 23125 IKV-AEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE---C 23180 Query: 552 AKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583 A+ S++ ++T L Y R+ A+N KG Sbjct: 23181 ARVKSLQAVIT--NLTQGEEYLFRVVAVNEKG 23210 Score = 47.4 bits (111), Expect = 6e-05 Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 4/193 (2%) Query: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK-DVRFIVLSNNYLQIRG 178 FK R +A +VC V P + W +G+++I R Y Q+ Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989 Query: 179 IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN---ATANLGQSVTLVC 235 TD+ + R +G + V VP I + + A G+ V++ Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049 Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295 G P+P ++W K + I+ + + +S + V++ D Y+ A+N+ G Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI 31109 Query: 296 QDATIHLKVFAKP 308 T+ L V P Sbjct: 31110 DQKTVELDVADVP 31122 Score = 47.0 bits (110), Expect = 7e-05 Identities = 89/415 (21%), Positives = 161/415 (38%), Gaps = 61/415 (14%) Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY----- 263 ++PP+I ++ + G +V +V +G P PT++W K + ++ Y Sbjct: 16115 DMPPSIDLKEFM---EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN 16171 Query: 264 -IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTAME 320 + DD+ L I + ++D Y A N G + L V + P + ++ ++ Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 16231 Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380 +Q+TL+ D S + + I E + V S + + T+ + + Sbjct: 16232 --DQMTLSWFPPKDDGGS---KITNYVIEKREANRKTWVHVSSEPKECTYTIPKL--LEG 16284 Query: 381 GEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438 EY+ A N G + + E + A L ++ G T S T++W Sbjct: 16285 HEYVFRIMAQNKYGI-GEPLDSEPETARNL------FSVPGAPDKPTVSSVTRNSMTVNW 16337 Query: 439 FR---DGQLLPSSNYSNIKIYNTPSASYLEVTPD-------------------SENDFGN 476 DG P + Y +++ +T S + V D S+ F Sbjct: 16338 EEPEYDGGS-PVTGYW-LEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRV 16395 Query: 477 YNCTAVNRIGQESLEFILVQAD---TPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILK 532 Y A +G SL A P P +V ++ S+A +++ P GG + Sbjct: 16396 YAINAAG-VGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTG 16454 Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGE 586 Y E++ G+E +W K+ + G + + GLK Y R+ A+N G+GE Sbjct: 16455 YIVEYKEEGKE----EWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGE 16505 Score = 47.0 bits (110), Expect = 7e-05 Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 10/116 (8%) Query: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252 I R ++ I+V V T+ I+ A G++ L D G P PTM W+KDG+ Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTV-----ILKA----GEAFRLEADVSGRPPPTMEWSKDGK 21500 Query: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 ++E E I +D S+ L K + D Y A N G ++KV +P Sbjct: 21501 ELEGTAKLEIKI-ADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555 Score = 47.0 bits (110), Expect = 7e-05 Identities = 96/520 (18%), Positives = 194/520 (37%), Gaps = 40/520 (7%) Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSD 267 +PP I+ ++ T ++ L +G P P + W +D GE +++ + + Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES----TS 21911 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327 + L + V++ D +YI EN +G + A ++++V P ++++E Sbjct: 21912 SYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP-----GPPQDLKVKEVTKT 21966 Query: 328 TCEASGDPIPSITWRTSTRN--ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385 + + DP P + + +N + E T + V ++ +S + +Q + + Sbjct: 21967 SVTLTWDP-PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 22025 Query: 386 TASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP--SATISWFR 440 A N G + ++ P G + + N V+++ E + S + + Sbjct: 22026 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 22085 Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---QESLEFILVQA 497 + Q S ++ A+ + E F +A N G L ++ Sbjct: 22086 EMQTKGSDKWATCATVKVTEATITGLIQGEEYSF---RVSAQNEKGISDPRQLSVPVIAK 22142 Query: 498 DTPSSPSIDQV-EPYSSTA--QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554 D P+ + ++ A ++ D P P + W + + +A+ Sbjct: 22143 DLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAV----TWHKDNVPLKQTTRVNAES 22198 Query: 555 ASMEGIVTIVGLKPETT--YAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMG 612 ++TI E Y V+L G+ + ++ K G P+ P ++ Sbjct: 22199 TENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDK----PGPPTGPVKMDEVT 22254 Query: 613 EDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEV 672 D ++ K DGGS I +Y+V R S+ + + L EY+ Sbjct: 22255 ADSITLSWGPPKY-DGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQF 22313 Query: 673 YVVAENQQGKSKAAHFVFRTSAQPTAIPA-NGSPTSGLST 711 + AEN+ GKS + + P +P G+P LS+ Sbjct: 22314 RIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSS 22353 Score = 46.2 bits (108), Expect = 1e-04 Identities = 95/398 (23%), Positives = 149/398 (37%), Gaps = 59/398 (14%) Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284 A G ++ + G P+PT++W K G+QI ++ + + S+ L I + ++D Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTW-KKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135 Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344 Y A N GE I ++V P ++ +E + S DP P Sbjct: 21136 YPLTARNIVGEVGDVITIQVHDIPG----PPTGPIKFDEVSSDFVTFSWDP-PENDGGVP 21190 Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTASNT--IGQDSQSMYL 400 N E + D V V T K+ + T EY A N +G S + Sbjct: 21191 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 21250 Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNY------S 451 Y K+ GP QV + S TISW DG P Y Sbjct: 21251 VANYPFKVPGPPGT-----PQVTAVTK----DSMTISWHEPLSDGG-SPILGYHVERKER 21300 Query: 452 NIKIYNTPSASYL--EVTPDSENDFG---NYNCTAVNRIGQESLEFILVQADTPSSP--S 504 N ++ T S + + + S G + A N G+ + PS P + Sbjct: 21301 NGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKS-------KPSKPSEPMLA 21353 Query: 505 IDQVEPYSS---------TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555 +D ++P T +++ +PE TGG I Y E R ++ + +W A + Sbjct: 21354 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKR----DLPNGRWLKANFS 21409 Query: 556 S-MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 + +E T+ GL + Y R+ A N G IS SE Sbjct: 21410 NILENEFTVSGLTEDAAYEFRVIAKN--AAGAISPPSE 21445 Score = 45.8 bits (107), Expect = 2e-04 Identities = 92/421 (21%), Positives = 157/421 (37%), Gaps = 47/421 (11%) Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269 +PP + N A G+ + + G P P ++W KD ++Q ++++ Sbjct: 22146 IPPAFKLLFNTFTVLA--GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAES-TENN 22202 Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329 S LTIK + D Y+ N AGE T+++ V KP ++++E + Sbjct: 22203 SLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG----PPTGPVKMDEVTADSI 22258 Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTA 387 S P P +S N E++ A V+ T+K+ + EY A Sbjct: 22259 TLSWGP-PKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 22317 Query: 388 SNTIGQDS--QSMYLEVQYAPKLQGP-----VAVYTWEGNQVNITCEVFAYPSATISWFR 440 N G+ + S QY K+ GP V + + + +V + S I + Sbjct: 22318 ENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHL 22377 Query: 441 DGQLLPSSNYSNIKIYNTP------SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 + + S + +K+ TP + LE + E N + + + S ++ Sbjct: 22378 ERKERNSILW--VKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVA 22435 Query: 495 VQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553 D P P V S T +Q+ +P GG I Y E + + E W Sbjct: 22436 RDPCDPPGRPEAIIVTRNSVT--LQWKKPTYDGGSKITGYIVEKKELPEGRW-------M 22486 Query: 554 EASMEGIV----TIVGLKPETTYAVRLAALNGKGL--------GEISAASEFKTQPVQGE 601 +AS I+ + GL + Y R+ A N G+ G I+A E + + Sbjct: 22487 KASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMD 22546 Query: 602 P 602 P Sbjct: 22547 P 22547 Score = 45.4 bits (106), Expect = 2e-04 Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 18/135 (13%) Query: 176 IRGIKKTDEGTYRCE--GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233 I G K D CE G I A + ++ + N T ++V A G S+ L Sbjct: 28331 INGAGKGDS----CEVTGTIKAVDRLTAPELDIDANFKQT-----HVVRA----GASIRL 28377 Query: 234 VCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293 +G P PT W+K + D +D S LT++ ++ND +Y EN + Sbjct: 28378 FIAYQGRPTPTAVWSKPDSNLSLRADIHT---TDSFSTLTVENCNRNDAGKYTLTVENNS 28434 Query: 294 GEQDATIHLKVFAKP 308 G + T +KV P Sbjct: 28435 GSKSITFTVKVLDTP 28449 Score = 45.1 bits (105), Expect = 3e-04 Identities = 62/275 (22%), Positives = 111/275 (40%), Gaps = 23/275 (8%) Query: 419 GNQVNITCEVFAYPSATISWFRD-GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477 G + I V P T W ++ G+L + + I N + S L + D G Y Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGEL----DKDRVVIDNVGTKSELIIKDALRKDHGRY 15174 Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQV---QFDEPEATGGVPILKYK 534 TA N G + + D P P +D ++P + ++ + +PE GG I + Sbjct: 15175 VITATNSCGSKFAAARVEVFDVPG-PVLD-LKPVVTNRKMCLLNWSDPEDDGGSEITGFI 15232 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594 E + W + + + + I GL Y R+ A N G G Sbjct: 15233 IERKDAKMHTWRQP-IETERSKCD----ITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 15287 Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLP 653 G P++P+ ++I ++ + + +GGSPI+ Y++ R KP+ Sbjct: 15288 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHD---KPDFERV 15344 Query: 654 S----GSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684 + + ++++LD + YE V A N+ G+S+ Sbjct: 15345 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESE 15379 Score = 43.9 bits (102), Expect = 6e-04 Identities = 58/247 (23%), Positives = 99/247 (40%), Gaps = 32/247 (12%) Query: 476 NYNCTAVNRIGQ----ESLEFILVQADT--PSSPS-IDQVEPYSSTAQVQFDEPEATGGV 528 ++ AVN+ G+ E + +L + PS P ++ + +TA +++ PE GG Sbjct: 14054 SFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGS 14113 Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588 PI Y E R V + W + K+ T+ L + Y R+AA N G + + Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTK----CTVTPLTEGSLYVFRVAAENAIGQSDYT 14169 Query: 589 AASEF----KTQPVQGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLV-RYR 640 + T G P A + D V+L ++DGG PI+ Y++ + Sbjct: 14170 EIEDSVLAKDTFTTPGPPYALAV-----VDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKE 14224 Query: 641 ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 700 L + W + + + + E + V AEN+ G ++PT I Sbjct: 14225 RLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGH--------PSEPTEIL 14276 Query: 701 ANGSPTS 707 + PTS Sbjct: 14277 SIEDPTS 14283 Score = 43.9 bits (102), Expect = 6e-04 Identities = 89/401 (22%), Positives = 154/401 (38%), Gaps = 68/401 (16%) Query: 288 IAENKAGEQD-ATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIPS 338 +A N AGE D A + V K ++ E + +++ + + L+ G P P Sbjct: 17190 LAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPK 17249 Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398 +TW+ R+ ++ + +D V S L +++ + D G Y T N G + S+ Sbjct: 17250 VTWKKEDRDAPTKAR-IDVTPVG------SKLEIRNAAHEDGGIYSLTVENPAGSKTVSV 17302 Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNYSNIKI 455 + V P G ++ S ++W DG + ++ + Sbjct: 17303 KVLVLDKP------------GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD 17350 Query: 456 YNTPSASYLEVTPDSENDF------GN---YNCTAVNRIGQ----ESLEFI--LVQADTP 500 + S L T ++ F GN + A N+ G+ E+ + I L P Sbjct: 17351 VASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPP 17410 Query: 501 SSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P + V+ + + +++P+ GG PI Y E++ G + W ++E Sbjct: 17411 GPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKF---KTVTNLEC 17467 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG----EISAASEFKTQPVQGEPSAPKLEGQMGEDG 615 +VT GL+ TY R+ A N GLG I + K P E +EG + + G Sbjct: 17468 VVT--GLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAG 17525 Query: 616 NSIK---------VNLIKQDDGGSPIR---HYLVRYRALSS 644 +++ V K GS I+ HY V SS Sbjct: 17526 TTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS 17566 Score = 43.1 bits (100), Expect = 0.001 Identities = 87/443 (19%), Positives = 174/443 (39%), Gaps = 57/443 (12%) Query: 14 LGTAVSLQVD---IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRIS 70 LG + L V+ I+ +++ E+ +V+ + WF + E ++ R+ Sbjct: 2784 LGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLV 2843 Query: 71 VVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR 130 ++ L + N + DAG Y VV G+ +++ V K M KN P Sbjct: 2844 ---SERKVHKLMLQNISPSDAGEYTAVV-GQLECKAKLFVETLHITKTM-KNIEVP---- 2894 Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRC 189 E + A C+V P++ W G ++ + + + +V + L I D Y Sbjct: 2895 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 2953 Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249 + +++ + P I + +NA + + + EG + W K Sbjct: 2954 ---VCGNDQVS----ATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLK 3003 Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309 +G +I+ + + S L I+ V D A+Y +A AT++++ Sbjct: 3004 NGVEIKSTDKCQMRTKKLTHS-LNIRNVHFGDAADYTFVAGKATST--ATLYVEARHIEF 3060 Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369 ++++ +E +++ CE S +P ++ W +E + + ++ V Sbjct: 3061 RKHIKDIKVLE-KKRAMFECEVS-EPDITVQWMKD-----DQELQITDRIKIQKEKYVHR 3113 Query: 370 LTLKSIQYTDAGEYICTASNTI--------GQD--SQSMYLEVQYAPKLQGPVAVYTWEG 419 L + S + +DAG+Y A + G+D +S+ EVQ K + AV +E Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQR---AVVEFEV 3170 Query: 420 NQVNITCEVFAYPSATISWFRDG 442 N+ ++ W++DG Sbjct: 3171 NEDDVDAH----------WYKDG 3183 Score = 43.1 bits (100), Expect = 0.001 Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 5/83 (6%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTIKKVDKNDEAEY 285 G+ +++ P PT+SW KDG++++ ++ +D S+ L + K + D Y Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEVKA---SDRLTMKNDHISAHLEVPKSVRADAGIY 14457 Query: 286 ICIAENKAGEQDATIHLKVFAKP 308 ENK G A+I++KV P Sbjct: 14458 TITLENKLGSATASINVKVIGLP 14480 Score = 43.1 bits (100), Expect = 0.001 Identities = 70/335 (20%), Positives = 110/335 (32%), Gaps = 47/335 (14%) Query: 405 APKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN------------ 452 APK+ ++ G+++ + + P TI+W +D ++ Sbjct: 14680 APKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGE 14739 Query: 453 --------------IKIYNTPSA-SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497 + I N+ S L V D G Y N G + Sbjct: 14740 VQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVL 14799 Query: 498 DTPSSPSIDQVEPYSSTAQV-QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 556 DTP P E T+ + +++ P GG I+ Y E + + S+W Sbjct: 14800 DTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKP--DSEWIVVTSTL 14857 Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN 616 ++ L Y R+ A N G G + + G P AP N Sbjct: 14858 RHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 14917 Query: 617 SIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 676 S+ V + D GSPI Y + R ++S + KSL + + Sbjct: 14918 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVN----------KSL-------LNALK 14960 Query: 677 ENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 711 N G + +VFR A+ A P SP S T Sbjct: 14961 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKT 14995 Score = 43.1 bits (100), Expect = 0.001 Identities = 95/483 (19%), Positives = 174/483 (36%), Gaps = 60/483 (12%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G S + +G P P ++W+++ + + EK + + +QL+I D+ND +YI Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGV---NYTQLSIDNCDRNDAGKYIL 24095 Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMEL-EEQVTLTCEASGDPIPSITWRTSTR 346 EN +G + A + +KV P +N E+ ++ L E P I + Sbjct: 24096 KLENSSGSKSAFVTVKVLDTPGPP--QNLAVKEVRKDSAFLVWEP-----PIIDGGAKVK 24148 Query: 347 N--ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404 N I E T + V S +S ++++ + A N G ++ Sbjct: 24149 NYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVK 24208 Query: 405 APKLQGPVAVYT------------WEGNQVNITCEVFAY-----PSATISWFRDGQLLPS 447 A + P T WE + + V Y P T W ++ Sbjct: 24209 AAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW----SIVAE 24264 Query: 448 SNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 507 S N + S + + N+ G + L ++ D PS+ Sbjct: 24265 SKVCNAVVTGLSSGQEYQFRVKAYNEKG--------KSDPRVLGVPVIAKDLTIQPSLKL 24316 Query: 508 VEPYSSTAQVQFDEPEATGGVPIL---KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV 564 P+ +T +Q E + +P++ + W GE + + + +E + ++ I Sbjct: 24317 --PF-NTYSIQAGE-DLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIK 24372 Query: 565 GLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK 624 + + A N G A+E + V +P P G + D S +I Sbjct: 24373 EGNKDDFGKYTVTATNSAG-----TATENLSVIVLEKPGPP--VGPVRFDEVSADFVVIS 24425 Query: 625 QD----DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 680 + GG I +Y+V R ++ + + + L EY+ + AEN+ Sbjct: 24426 WEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRY 24485 Query: 681 GKS 683 GKS Sbjct: 24486 GKS 24488 Score = 42.4 bits (98), Expect = 0.002 Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 24/150 (16%) Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511 N ++ + + ++ +EN+ G +G S ++ + P+SP ++ + Sbjct: 14242 NFRVTDVIEGTEVQFQVRAENEAG---------VGHPSEPTEILSIEDPTSPPSPPLDLH 14292 Query: 512 SSTA-----QVQFDEPEATGGVPILKYKAEWRAVGEEVW----HSKWYDAKEASMEGIVT 562 + A + + PE GG PI+ Y E VG E W D K EG+V Sbjct: 14293 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVV- 14351 Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASE 592 P+ Y +R+ A+N G+ E S SE Sbjct: 14352 -----PDKEYVLRVRAVNAIGVSEPSEISE 14376 Score = 42.4 bits (98), Expect = 0.002 Identities = 87/468 (18%), Positives = 169/468 (36%), Gaps = 32/468 (6%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G S+ + +G P P ++WTKD ++ + E ++ + L I + ++ D +++ Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIEN---TESFTLLIIPECNRYDTGKFVM 20847 Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347 EN AG++ ++++V P T + ++ VTL + +P I + N Sbjct: 20848 TIENPAGKKSGFVNVRVLDTPGPVLNLRPTDI-TKDSVTLHWD-----LPLIDGGSRITN 20901 Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYA 405 E++ + + T K ++ EY A N G + E A Sbjct: 20902 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 20961 Query: 406 PKLQGPVAVYTWEGNQVNITCEV--FAYP-------SATISWFRDGQLLPSSNYSNIKIY 456 + P N ++IT A+P S + + Q S +++I Sbjct: 20962 SEAPSPPDSL----NIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV 21017 Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ 516 +T E F + R ++V+ T P +D Y Sbjct: 21018 KGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT-MLPELDLRGIYQKLVI 21076 Query: 517 VQFDEPEATGGVPIL---KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYA 573 + + +P+L K W+ + + ++ + + + I+ I + Sbjct: 21077 AKAGD-NIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135 Query: 574 VRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR 633 L A N +GE+ + + G P+ P ++ D + + ++DGG PI Sbjct: 21136 YPLTARN--IVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWD-PPENDGGVPIS 21192 Query: 634 HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681 +Y+V R S E+ L EY+ V A+N+ G Sbjct: 21193 NYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYG 21240 Score = 42.4 bits (98), Expect = 0.002 Identities = 50/209 (23%), Positives = 89/209 (42%), Gaps = 14/209 (6%) Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267 + + P+++ N + A G+ + + G P P +SW KDGE ++Q + Sbjct: 24308 LTIQPSLKLPFNTYSIQA--GEDLKIEIPVIGRPRPNISWVKDGEPLKQ-TTRVNVEETA 24364 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327 S+ L IK+ +K+D +Y A N AG + + V KP + + V + Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424 Query: 328 TCEASGDPIPSITWRTSTRNISSEEK---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384 + E P+ T N E++ T HMV + AR +++ + ++ ++ Sbjct: 24425 SWEP-----PAYTGGCQISNYIVEKRDTTTTTWHMVSATVAR-TTIKITKLKTGTEYQFR 24478 Query: 385 CTASNTIGQDS--QSMYLEVQYAPKLQGP 411 A N G+ + S + VQY K GP Sbjct: 24479 IFAENRYGKSAPLDSKAVIVQYPFKEPGP 24507 Score = 42.4 bits (98), Expect = 0.002 Identities = 59/273 (21%), Positives = 101/273 (36%), Gaps = 22/273 (8%) Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478 G V + P+A + W+ +G L S S I NT LE+ +D G Y Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQES--SKIHYTNTSGVLTLEILDCHTDDSGTYR 32445 Query: 479 CTAVNRIGQES----LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534 N G+ S L+ T +S D+ P S ++ E A Sbjct: 32446 AVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAV--------- 32496 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594 + ++ E S + K E ++ + + ++ AAL K L E S + K Sbjct: 32497 SSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIK 32556 Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH--YLVRYRALSSEWKPEIRL 652 T + P+ +G S + + D G P+ +L + + LS+ + ++ Sbjct: 32557 TTLAARILTKPR--SMTVYEGESARFSC---DTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611 Query: 653 PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685 + S+ + E VV EN +GK +A Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 32644 Score = 42.0 bits (97), Expect = 0.002 Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 10/119 (8%) Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 GEI DIQ V I A+ +V G + + +G P P SW DG+ + Sbjct: 15797 GEIPATDIQEEPEVFIDIGAQDCLV---CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKA 15853 Query: 257 EED-------DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 +D D + +++SS + I + ++ +Y A+NKAG++ A +KV P Sbjct: 15854 MKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912 Score = 42.0 bits (97), Expect = 0.002 Identities = 78/367 (21%), Positives = 139/367 (37%), Gaps = 61/367 (16%) Query: 253 QIEQEEDDEKYIFSDDS----SQLTIKKVDKNDEAEYICIAENKAG-EQDATIHLKVFAK 307 +I E+DE I + + + TI + +N E + A N G + A + A+ Sbjct: 21793 EIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAE 21852 Query: 308 PKITYVENQTAMELEEQVTLTC--------EASGDPIPSITWRTSTRNISSEEKTLDGHM 359 ++ E + +L + VT+ G P P + W ++LD Sbjct: 21853 DRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD------HGESLD-KA 21905 Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419 + S + + L + ++ D+G+YI T N+ G S + + V P G Sbjct: 21906 SIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP------------G 21953 Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY-----NTPSASYLEVTPDSEN-- 472 ++ + S T++W D LL S IK Y + +Y V + Sbjct: 21954 PPQDLKVKEVTKTSVTLTW--DPPLLDGG--SKIKNYIVEKRESTRKAYSTVATNCHKTS 22009 Query: 473 ---DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ----------VEPYSSTAQVQF 519 D C+ R+ E+ I + A+T S + ++ ++ + + Sbjct: 22010 WKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSW 22069 Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579 ++PE GG IL Y E + G + KW + TI GL Y+ R++A Sbjct: 22070 EKPEHDGGSRILGYIVEMQTKGSD----KWATCATVKVTE-ATITGLIQGEEYSFRVSAQ 22124 Query: 580 NGKGLGE 586 N KG+ + Sbjct: 22125 NEKGISD 22131 Score = 41.6 bits (96), Expect = 0.003 Identities = 89/449 (19%), Positives = 165/449 (36%), Gaps = 66/449 (14%) Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92 +GE+ CQ+ G DI W+ E + + ++S +D + TLT+ +D G Sbjct: 30546 LGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMS---SDGRTHTLTVMTEEQEDEG 30601 Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV--VSSLPPTII 150 +Y C+ T E G ++ + P +++ + + V + P + Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661 Query: 151 WKHKGRDVILKKDVRFIVLSNNY--LQIRGI-KKTDEGTYRCEGRILARGEINFKDIQVI 207 W H G+ ++ + I + +Y L ++ + +KT G Y+ + + Sbjct: 30662 WFH-GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ----------------L 30704 Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW---TKDG---------EQIE 255 NV T+ A ++ + +V +A +SW DG E+ E Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCE 30764 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQD------ATIHLKVFAK 307 +E E + S S T + V+ + A Y A+N G D I F K Sbjct: 30765 AKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEK 30824 Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSH 364 P TA+ + +C + P P+ RN E+K V Sbjct: 30825 PGAPGKPTITAVTKD-----SCVVAWKP-PASDGGAKIRNYYLEKREKKQNKWISVTTEE 30878 Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV--YTWEGNQV 422 R + ++K++ E+ N +G +S+ + PK P+ + E + Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCEN-LGGESEWSEISEPITPKSDVPIQAPHFKEELRNL 30937 Query: 423 NI--------TCEVFAYPSATISWFRDGQ 443 N+ C+V +P + W+R G+ Sbjct: 30938 NVRYQSNATLVCKVTGHPKPIVKWYRQGK 30966 Score = 41.2 bits (95), Expect = 0.004 Identities = 99/457 (21%), Positives = 165/457 (36%), Gaps = 67/457 (14%) Query: 162 KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV 221 K +F V + N + + + + EG Y + ++L PP I + I Sbjct: 18867 KKYKFRVAARNAVGV-SLPREAEGVYEAKEQLL----------------PPKILMPEQI- 18908 Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281 T G+ + + G P PT W K +++ + +D SS L IK V + D Sbjct: 18909 --TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHK-ADSSSILIIKDVTRKD 18965 Query: 282 EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW 341 Y AEN +G I + V P Q ++ + C S IP Sbjct: 18966 SGYYSLTAENSSGTDTQKIKVVVMDAPG----PPQPPFDISDIDADACSLSWH-IPLEDG 19020 Query: 342 RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMY 399 ++ N E+ + V + A V+ + + + EYI A N G Sbjct: 19021 GSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFG------I 19074 Query: 400 LEVQYAPKL--QGPVAVYTWEGN----QVNITCEVFAYP-------SATISWF-----RD 441 E +PK+ Q P V + N +VN C A+ S I + R+ Sbjct: 19075 SEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 19134 Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ- 496 L +N + ++ P A +E E F Y A+N+ G + E++ + Sbjct: 19135 SLLWVKANDTLVRSTEYPCAGLVE---GLEYSFRIY---ALNKAGSSPPSKPTEYVTARM 19188 Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555 D P P + ++ ST + + P+ GG I+ Y E + + W + A Sbjct: 19189 PVDPPGKPEV--IDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKW-VRCNTAPHQ 19245 Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 + T GL+ + Y R A + S S+ Sbjct: 19246 IPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSD 19282 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 10/143 (6%) Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQAD--TPSSPSIDQV-EPYSSTAQ 516 L+VT E + TAVN G E+ FI + TP PS +V + + Sbjct: 29300 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 29359 Query: 517 VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRL 576 + + +P GG I+ Y E + + W+ +A + E T+ LK Y+ R+ Sbjct: 29360 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE--FTVPDLKMGQKYSFRV 29417 Query: 577 AALNGKGLGEISAASEFKTQPVQ 599 AA+N KG+ E S S + +PV+ Sbjct: 29418 AAVNVKGMSEYS-ESIAEIEPVE 29439 Score = 40.8 bits (94), Expect = 0.005 Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%) Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470 P V EG C V YP ++W+ +GQL+ S ++ YL++ Sbjct: 1847 PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHYLDIVDCK 1903 Query: 471 ENDFGNYNCTAVNRIG------------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518 D G TA N G +E +L +A P P EP +VQ Sbjct: 1904 SYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEP-RPEFHVHEPGKLQFEVQ 1962 Query: 519 -FDEP-EATGGVPILKYKAEWRAVGEEV------WHSKWYDAKEASMEGIVTIVGLK 567 D P + T ++K K R E+V SK+ E +T V LK Sbjct: 1963 KVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELK 2019 Score = 40.8 bits (94), Expect = 0.005 Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 55/382 (14%) Query: 81 LTIYNANIDDAG--IYKCVVTGEDGSESEATVNVKIFQ---KLMFKNAPTPQEFREGEDA 135 LT++ +D AG +Y+ + + + A + VK + + K+ P+ + + Sbjct: 11453 LTLHKVKLDQAGEVLYQAL-----NAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC 11507 Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192 V+ + +IW KG D+I D +F ++++ + L I + DEG Y E Sbjct: 11508 VLTREA------NVIWS-KGPDIIKSSD-KFDIIADGKKHILVINDSQFDDEGVYTAE-- 11557 Query: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252 G+ K + ++ + + T G++ T VC+ + + W K+ Sbjct: 11558 --VEGK---KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS-HEKMHVVWFKNDA 11611 Query: 253 QIEQEEDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPK 309 ++ + S + +L +K+V +D ++ + + E +T LKV A P Sbjct: 11612 KLHTSRT---VLISSEGKTHKLEMKEVTLDDISQI----KAQVKELSSTAQLKVLEADPY 11664 Query: 310 ITY-VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368 T + ++TA+E +E +TL CE S D +P + W I K +++ Sbjct: 11665 FTVKLHDKTAVEKDE-ITLKCEVSKD-VP-VKWFKDGEEIVPSPK-----YSIKADGLRR 11716 Query: 369 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ-YAPKLQGPV-AVYTWEGNQVNITC 426 L +K D GEY+C G D + V+ K++ P+ V + G + Sbjct: 11717 ILKIKKADLKDKGEYVCDC----GTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEI 11772 Query: 427 EVFAYPSATISWFRDGQLLPSS 448 E+ + P W GQ L +S Sbjct: 11773 EL-SEPDVHGQWKLKGQPLTAS 11793 Score = 40.4 bits (93), Expect = 0.007 Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 7/101 (6%) Query: 211 PPTIQARQNIVNATANL-GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD-- 267 PP ++ ++ + G+++ + G P PT WTK+ E E D ++ + + Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKE----EGELDKDRVVIDNVG 15156 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 S+L IK + D Y+ A N G + A ++VF P Sbjct: 15157 TKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197 Score = 40.0 bits (92), Expect = 0.009 Identities = 85/396 (21%), Positives = 155/396 (39%), Gaps = 90/396 (22%) Query: 279 KNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLTCEAS----- 332 ++ + ++ A NK G D + + K + K + E + +L + + L + Sbjct: 19656 EDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYV 19715 Query: 333 ---GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 389 G P P ITW S N++ ++ + ++S + L +++ DAG+YI T N Sbjct: 19716 PVKGRPPPKITW--SKPNVNLRDRI---GLDIKSTDFDTFLRCENVNKYDAGKYILTLEN 19770 Query: 390 TIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLP 446 + G+ ++ ++V P G VN+T + + SA ++W DG P Sbjct: 19771 SCGKKEYTIVVKVLDTP------------GPPVNVTVKEISKDSAYVTWEPPIIDGG-SP 19817 Query: 447 SSNY---------------------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485 NY ++ ++ N +EN++G I Sbjct: 19818 IINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYG---------I 19868 Query: 486 GQESLEFILVQADTPSSPSID-QVEPYS-STAQVQFDEPEATGGVPILKY-------KAE 536 G V+A P +D +V S S+ + + +P + GG I+ Y + + Sbjct: 19869 GDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK 19928 Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTI---------VGLKPETTYAVR----LAALNGKG 583 W+ V + + S Y AK+ + T G E T R L+ KG Sbjct: 19929 WQRVMKSL--SLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKG 19986 Query: 584 LGEI----SAASEFKTQ-PVQGEPSAPKLEGQMGED 614 L ++ S F+ + P++G+P AP + + GED Sbjct: 19987 LPDLCYLAKENSNFRLKIPIKGKP-APSVSWKKGED 20021 Score = 40.0 bits (92), Expect = 0.009 Identities = 29/150 (19%), Positives = 65/150 (43%), Gaps = 8/150 (5%) Query: 166 FIVLSNNYLQIRGIKKTDEGTYRCEGR----ILARGEINFKDIQVIVNVPPT---IQARQ 218 + ++S+N+ + + + D +R + ++++G + + P + AR Sbjct: 28993 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 29052 Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278 + T G + L G PEP + WTK ++++ E ++ + IK D Sbjct: 29053 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCE-KVSLQYTGKRATAVIKFCD 29111 Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKP 308 ++D +Y +N +G + ++ +KV P Sbjct: 29112 RSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141 Score = 39.7 bits (91), Expect = 0.012 Identities = 79/392 (20%), Positives = 147/392 (37%), Gaps = 74/392 (18%) Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA----MELEEQV 325 +Q + + ++ + A N AG + + P + VE + A ++ E + Sbjct: 20731 TQFVVPDLQTKEKYNFRISAINDAGVGEPAVI------PDVEIVEREMAPDFELDAELRR 20784 Query: 326 TLTCEAS----------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 TL A G P P +TW N+ + + + + L + Sbjct: 20785 TLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRAN-------IENTESFTLLIIPEC 20837 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 D G+++ T N G+ S + + V P GPV +N+ S T Sbjct: 20838 NRYDTGKFVMTIENPAGKKSGFVNVRVLDTP---GPV---------LNLRPTDITKDSVT 20885 Query: 436 ISW--------FRDGQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVN 483 + W R + + K Y+T + +VT SE + A N Sbjct: 20886 LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAEN 20945 Query: 484 RIG----QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538 G E+ E + ++ PS P S++ ++ ST + + +P+ GG I Y E + Sbjct: 20946 EYGIGEPTETTEPVKA-SEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQ 21004 Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIV-GLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 G + W +++G+ +V L Y ++ A+N G SA E + Sbjct: 21005 RKGSDQW------THITTVKGLECVVRNLTEGEEYTFQVMAVNSAGR---SAPRESRPVI 21055 Query: 598 VQGEPSAPKLEGQ-------MGEDGNSIKVNL 622 V+ + P+L+ + + + G++IKV + Sbjct: 21056 VKEQTMLPELDLRGIYQKLVIAKAGDNIKVEI 21087 Score = 39.3 bits (90), Expect = 0.016 Identities = 81/436 (18%), Positives = 157/436 (36%), Gaps = 66/436 (15%) Query: 102 DGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK 161 +G+ + T + K QK P P EGE A C V P + W G+ +++ Sbjct: 1825 EGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ--LIR 1882 Query: 162 KDVRFIVLSN--NYLQIRGIKKTDEGTYRC-----EGRILARGEI------NFKDI---- 204 K RF V + +YL I K D G + EG I + ++ +F+ + Sbjct: 1883 KSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRA 1942 Query: 205 -----QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE---Q 256 + V+ P +Q V+ + ++ +V ++ E++ + Sbjct: 1943 PEPRPEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFK 2002 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDE-------------AEYICIAENKAGEQDATIHLK 303 +E Y + + +L +K D++ E + + E KA ++ I + Sbjct: 2003 RRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIP 2062 Query: 304 VFAKPKITYVENQTAMELEEQVT-----------LTCEASGDPIPSITWRTSTRNISSEE 352 F KI + A ++ E++ G P P W + I + Sbjct: 2063 TFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSD 2122 Query: 353 KTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ------YAP 406 + V L ++ + D+ + A N G+ S +L VQ + Sbjct: 2123 RI----YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2178 Query: 407 KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 466 +LQ VA + CE + P + W++DG + + ++++ +L + Sbjct: 2179 ELQDVVA--KEKDTMATFECET-SEPFVKVKWYKDGMEVHEGD--KYRMHSDRKVHFLSI 2233 Query: 467 TPDSENDFGNYNCTAV 482 +D +Y+C V Sbjct: 2234 LTIDTSDAEDYSCVLV 2249 Score = 38.9 bits (89), Expect = 0.020 Identities = 45/217 (20%), Positives = 86/217 (39%), Gaps = 13/217 (5%) Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258 + +D++V+ + + ++ I G+ V LV G P P SW G ++ + E Sbjct: 29727 VTVQDLRVLPTIDLSTMPQKTI---HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESE 29783 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 + ++LTI++ D EY +N G TI + + KP Sbjct: 29784 RVTVETHT-KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG----PPTGP 29838 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 ++++E + S +P P + E++ + V+ T K + T Sbjct: 29839 IKIDEIDATSITISWEP-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLT 29897 Query: 379 DAGEYICTASNT----IGQDSQSMYLEVQYAPKLQGP 411 + EY+ + T IG QS +E + + ++ GP Sbjct: 29898 EGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 29934 Score = 38.1 bits (87), Expect = 0.035 Identities = 47/204 (23%), Positives = 77/204 (37%), Gaps = 15/204 (7%) Query: 117 KLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQI 176 K +F P + EG+ A VV P W H G+ ++ + ++ + + Sbjct: 1456 KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSL 1515 Query: 177 RGIKKT--DEGTYRCEGRILARGEINFKDIQVIVNVPPT-IQARQNIVNATANL----GQ 229 + T D G E ++A+ I VI+ V Q + V N+ G Sbjct: 1516 IIVPATPSDSG----EWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571 Query: 230 SVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQLTIKKVDKNDEAEYICI 288 + + A G P P + W K+ + I + + I + + L I D A Y Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631 Query: 289 AENKAGEQDATIHLKV---FAKPK 309 A NKAG + V FA+P+ Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPE 1655 Score = 38.1 bits (87), Expect = 0.035 Identities = 95/438 (21%), Positives = 176/438 (40%), Gaps = 47/438 (10%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 + G F +V G D + W+ NG K+ RI W +D+ L I + +D Sbjct: 2089 VGQGSDAHFRVRVVGKP-DPECEWYK-NGVKIE-RSDRIYWYWPEDNVCELVIRDVTAED 2145 Query: 91 AG--IYKCV-VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP- 146 + + K + + GE S + V K Q + F +E +D + + +S P Sbjct: 2146 SASIMVKAINIAGETSSHAFLLVQAK--QLITFTQELQDVVAKE-KDTMATFECETSEPF 2202 Query: 147 PTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203 + W G +V + ++ + S+ ++L I I +D Y C +L E Sbjct: 2203 VKVKWYKDGMEV--HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSC---VLVEDENVKTT 2257 Query: 204 IQVIVN--VPPTIQARQNIVNATANLGQSVTLVC--DAEGFPEPTMSWTKDGEQIEQEED 259 ++IV V ++ Q+I + G+ +V + EG W + +E + + Sbjct: 2258 AKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEG------KWYHN--DVELKSN 2309 Query: 260 DEKYIFSDDSSQ-LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318 + I S Q LT+K V K D+ EY + + K T LK+ +P I ++ + Sbjct: 2310 GKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK----KTTCKLKMKPRP-IAILQGLSD 2364 Query: 319 MELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 ++ E V L + S + + + W + + ++ H+V+ + + L ++ + Sbjct: 2365 QKVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRV---HIVIDKQSHM--LLIEDMT 2418 Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATI 436 DAG Y T +G S S + V + V EG + + C+V ++ Sbjct: 2419 KEDAGNYSFTIP-ALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSV 2476 Query: 437 SWF-RDGQLLPSSNYSNI 453 W+ D Q+ P I Sbjct: 2477 KWYLNDEQIKPDDRVQAI 2494 Score = 38.1 bits (87), Expect = 0.035 Identities = 94/418 (22%), Positives = 162/418 (38%), Gaps = 55/418 (13%) Query: 238 EGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297 +G P P++SW K GE + S ++ L + K+D +Y +N AG ++ Sbjct: 20007 KGKPAPSVSWKK-GEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKE 20065 Query: 298 ATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG 357 TI +KV KP I T ++VT P + N E++ Sbjct: 20066 GTISIKVVGKPGI-----PTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN 20120 Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNT----IGQDSQSMYLEVQY---APKLQG 410 + V + V T + + + EY S +G+ +S + ++ P Sbjct: 20121 NKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPP 20180 Query: 411 PVAVYTWEGNQVNITCEVFAYPSAT----ISWF------RDGQLLPSSNYSNIKIYNTPS 460 P + + V++T + P T I+ + R+ L +N + I++ + Sbjct: 20181 PPNIVDVRHDSVSLT---WTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD--- 20234 Query: 461 ASYLEVTPDSENDFGNYNCTAVN--RIGQESLEFILVQA----DTPSSPSIDQVEPYSST 514 +VT +E + A+N +G+ SL V A D P P + + S T Sbjct: 20235 ---FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT 20291 Query: 515 AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYA 573 + + EP+ GG + Y E R ++ W A ++ E T+ L Y Sbjct: 20292 --LIWTEPKYDGGHKLTGYIVEKR----DLPSKSWMKANHVNVPECAFTVTDLVEGGKYE 20345 Query: 574 VRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKL-------EGQMGEDGNSIKVNLI 623 R+ A N G ISA SE +T + E AP + +G + G++I +N I Sbjct: 20346 FRIRAKN--TAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAI 20401 Score = 37.0 bits (84), Expect = 0.077 Identities = 132/672 (19%), Positives = 229/672 (34%), Gaps = 95/672 (14%) Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIF---- 115 EK + R S+ N DSSS LTI +D G Y + G +TV+VK+ Sbjct: 27309 EKNLGSDARYSIE-NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPA 27367 Query: 116 --QKLMFKNAPTPQEFREGEDAVIVCD--VVSSLPPTIIWKHKGRDVILKKDVRFIVLSN 171 QKL K+ ++ D ++ P I + + RD K+ + Sbjct: 27368 ACQKLQVKHVSRGT-------VTLLWDPPLIDGGSPIINYVIEKRDAT-KRTWSVVSHKC 27419 Query: 172 NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSV 231 + + I +++ + R+LA EI + + I + + Sbjct: 27420 SSTSFKLIDLSEKTPFFF--RVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 27477 Query: 232 TLVCDAEGFPEPTMSWTK---DGEQIEQE---------EDDEKYIFSDDSSQLTIKKVDK 279 +++ +SWTK DG + E E + + ++ + ++ + Sbjct: 27478 SVI----------LSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKE 27527 Query: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEA 331 E+ A+N+ G D + K I E Q + + V L Sbjct: 27528 QSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY 27587 Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTL--KSIQYTDAGEYICTASN 389 G P PSI+W + E VR + +TL K+ + G+Y N Sbjct: 27588 KGKPKPSISWLKDGLPLKESE-------FVRFSKTENKITLSIKNAKKEHGGKYTVILDN 27640 Query: 390 TIGQDSQSMYLEVQYAP-KLQGPV---------AVYTWEGNQVN----ITCEVFAYPSAT 435 + + + + + P K +GP+ + +W+ + N ITC ++ Sbjct: 27641 AVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITC--YSIEKRE 27698 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 S + S + K+ N + + +EN +G + Q + I+V Sbjct: 27699 TSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYG---------VSQPLVSSIIV 27749 Query: 496 Q------ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549 P P I V S + +D P GG + + E + +W K Sbjct: 27750 AKHQFRIPGPPGKPVIYNVT--SDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILW-QKV 27806 Query: 550 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEG 609 + + E T GL Y R+ A N GL S S+F +P Sbjct: 27807 NTSPISGREYRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYI 27864 Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAE 669 + + ++K N + DGGS I Y + R + W + L Sbjct: 27865 DVTRETITLKWNPPLR-DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDR 27923 Query: 670 YEVYVVAENQQG 681 YE ++A N G Sbjct: 27924 YEFRIIARNAVG 27935 Score = 36.6 bits (83), Expect = 0.10 Identities = 81/383 (21%), Positives = 136/383 (35%), Gaps = 65/383 (16%) Query: 271 QLTIKKVDKNDEAEYICIAENKAGE---------------QDATIHLKVFAKPKITYVEN 315 Q T+K++ + + + A N AGE + + L V K I + Sbjct: 15060 QYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAG 15119 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKS 374 +T + + +G P+P+ W + EE LD VV + S L +K Sbjct: 15120 KT-------LRIPAVVTGRPVPTKVW-------TKEEGELDKDRVVIDNVGTKSELIIKD 15165 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434 D G Y+ TA+N+ G + +EV P GPV +++ V Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVP---GPV---------LDLKPVVTNRKMC 15213 Query: 435 TISWF---RDG-----QLLPSSNYSNIKIYNTP---SASYLEVTPDSENDFGNYNCTAVN 483 ++W DG + + + + P S ++T E + A N Sbjct: 15214 LLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKN 15273 Query: 484 RIG-QESLEFILVQADTPSSP-----SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537 + G +E + A P P + E ST + + EP + GG PI Y E Sbjct: 15274 KFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEK 15333 Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 R + + K + L Y R+ A+N G E S Sbjct: 15334 RRHDKPDFERV---NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNV---V 15387 Query: 598 VQGEPSAPKLEGQMGEDGNSIKV 620 +Q + P ++ ++ G++IKV Sbjct: 15388 IQDDEVPPTIKLRLSVRGDTIKV 15410 Score = 36.6 bits (83), Expect = 0.10 Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED-DEKYIFSDDSSQLTIKKVDKNDEAEYI 286 G ++ L +G P P ++W+K + D K +D + L + V+K D +YI Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKS--TDFDTFLRCENVNKYDAGKYI 19765 Query: 287 CIAENKAGEQDATIHLKVFAKP 308 EN G+++ TI +KV P Sbjct: 19766 LTLENSCGKKEYTIVVKVLDTP 19787 Score = 36.6 bits (83), Expect = 0.10 Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 5/82 (6%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS-SQLTIKKVDKNDEAEYI 286 G S T+ G P P + W+K + Y+ + DS + LTI+ ++ND +Y Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRA----YVDTTDSRTSLTIENANRNDSGKYT 26256 Query: 287 CIAENKAGEQDATIHLKVFAKP 308 +N T+ +KV P Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTP 26278 Score = 36.2 bits (82), Expect = 0.13 Identities = 52/239 (21%), Positives = 86/239 (35%), Gaps = 26/239 (10%) Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN----YLQIRGIKKTDEGT 186 EG A + P + W G+ VI + + +S + L I + K + G Sbjct: 19 EGSTATFEAHISGFPVPEVSWFRDGQ-VISTSTLPGVQISFSDGRAKLTIPAVTKANSGR 77 Query: 187 YRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241 Y + G+ + E+ K PP Q + + T G V L G P Sbjct: 78 YSLKATNGSGQATSTAELLVK----AETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131 Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301 P + + +DG +I Q D + D L I + D Y A N G +T Sbjct: 132 TPVVKFYRDGAEI-QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190 Query: 302 LKVFAKPKITYVENQTAM---ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG 357 L V + ++ + +T + ++ E E I R+I++ E +DG Sbjct: 191 LLVQGEEEVPAKKTKTIVSTAQISESRQTRIE------KKIEAHFDARSIATVEMVIDG 243 Score = 35.8 bits (81), Expect = 0.17 Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%) Query: 14 LGTAVSLQVDIVPSQGE-------ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ 66 L T+ L+++ P Q +S +S F C+V+ D D ++W+ E LT +Q Sbjct: 8821 LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFD--DAIVTWYKGPTE-LTESQ 8877 Query: 67 QRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117 + ND +TI+N DD G+Y + E E+ +T + + K Sbjct: 8878 KYN--FRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTK 8926 Score = 35.8 bits (81), Expect = 0.17 Identities = 116/552 (21%), Positives = 202/552 (36%), Gaps = 80/552 (14%) Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93 G+ + C++ K++D+ W +G+ + RI V LTI +A+ DAG Sbjct: 11227 GQPLYLSCELN---KERDVVW-RKDGKIVVEKPGRI-VPGVIGLMRALTINDADDTDAGT 11281 Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y V + E + V V + Q + A+ CD+ P I W Sbjct: 11282 YTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKD-TPNIKW-F 11339 Query: 154 KGRDVILKK--DVRFIVLSNN--YLQIRGIKKTDEGTYRCE---GRILARGEINFKDIQV 206 KG D I + D I+ N YL+I+ D Y E R A+ + +++++ Sbjct: 11340 KGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVEL 11399 Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS 266 + + + + A + ++ D G W GE + E I + Sbjct: 11400 LKPIEDVTIYEKESASFDAEISEA-----DIPG------QWKLKGELLRPSPTCE--IKA 11446 Query: 267 DDSSQ-LTIKKVDKNDEAEYICIAEN---------KAGEQDATIHLKVFAKPKITYVENQ 316 + + LT+ KV + E + A N K E D + LK +T E + Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLK-----DVTVPERR 11501 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 A + LT EA ++ W I S +K + + + L + Q Sbjct: 11502 QA---RFECVLTREA------NVIWSKGPDIIKSSDK-----FDIIADGKKHILVINDSQ 11547 Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSAT 435 + D G Y + G+ + + K P+ T EG CE+ ++ Sbjct: 11548 FDDEGVY---TAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMH 11603 Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495 + WF++ L +S + I + LE+ + +D L+ ++ Sbjct: 11604 VVWFKNDAKLHTSR--TVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLK--VL 11659 Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDE----PEATGGVPILKYKAEWRAVGEEVWHSKWYD 551 +AD + V+ + TA V+ DE E + VP+ +W GEE+ S Y Sbjct: 11660 EADPYFT-----VKLHDKTA-VEKDEITLKCEVSKDVPV-----KWFKDGEEIVPSPKYS 11708 Query: 552 AKEASMEGIVTI 563 K + I+ I Sbjct: 11709 IKADGLRRILKI 11720 Score = 35.8 bits (81), Expect = 0.17 Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 15/112 (13%) Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P +P + ++ S+ + +++P GG I Y E E+ W A + Sbjct: 21759 PGNPRV--LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS- 21815 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQM 611 TI GL Y +R+ A+N +GLGE + P PK E +M Sbjct: 21816 -YTITGLTENQEYKIRIYAMNSEGLGEPALV-----------PGTPKAEDRM 21855 Score = 35.4 bits (80), Expect = 0.22 Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 2/58 (3%) Query: 626 DDGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 682 DDGGS I +Y+V R S++W P H K L+ +Y V AENQ G+ Sbjct: 17335 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSH-FAKHLNEGNQYLFRVAAENQYGR 17391 Score = 33.9 bits (76), Expect = 0.65 Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 6/93 (6%) Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 PS P I V+ +T + + +P GG PI Y E++ + W + + Sbjct: 26087 PSKPKI--VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTE--- 26141 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 TI GL Y R+ ++N G + S +S+ Sbjct: 26142 -YTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173 Score = 33.5 bits (75), Expect = 0.85 Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 6/131 (4%) Query: 585 GEISAASEFKTQPVQGEPSAPKLEG-QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS 643 G+ +A K V G P K+ G S K+ DDGG I+ Y++ R + Sbjct: 15898 GQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKM---PDDDGGDRIKGYVIEKRTID 15954 Query: 644 SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANG 703 + ++ GS ++ L +Y V AEN+ G + RT+A+ P + Sbjct: 15955 GKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPD- 16013 Query: 704 SPTSGLSTGAI 714 P L G I Sbjct: 16014 -PPIKLKIGLI 16023 Score = 33.5 bits (75), Expect = 0.85 Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 43/312 (13%) Query: 40 LCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT 99 +C+V G K + W+ G+++ + + + L I + DDA +Y+ T Sbjct: 30948 VCKVTGHPKPI-VKWYR-QGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRAT 31005 Query: 100 GEDGSES-----EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154 + GS S E V KI + R GE I P I W+ K Sbjct: 31006 NQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALR-GEVVSIKIPFSGKPDPVITWQ-K 31063 Query: 155 GRDVILKKDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRILARGEINFKDIQV-IVNV 210 G+D+I ++++ ++ + G+++ D G Y + R I+ K +++ + +V Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAK--NRFGIDQKTVELDVADV 31121 Query: 211 P------PTIQARQNIVNAT----ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260 P ++ VN T A+ G S E W + G+ E Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARE----- 31176 Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320 ++ T+ + ++ IAENK G + ++P IT + AM Sbjct: 31177 ---------TRYTVINLFGKTSYQFRVIAENKFGLSKPSEP----SEPTITKEDKTRAMN 31223 Query: 321 LEEQVTLTCEAS 332 +E+V T E S Sbjct: 31224 YDEEVDETREVS 31235 Score = 32.3 bits (72), Expect = 1.9 Identities = 67/287 (23%), Positives = 107/287 (37%), Gaps = 46/287 (16%) Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500 DG+ L NY+NI+ +Y EVT +E+ + A N S + Sbjct: 25728 DGRWL-KCNYTNIQ------ETYFEVTELTEDQRYEFRVFARNAADSVS------EPSES 25774 Query: 501 SSPSI--DQVEPYSSTAQVQFDEPEATGGVPILKYKAE----------WRAVGEEVWHSK 548 + P I D VEP V+F + +LK A+ W G E+ Sbjct: 25775 TGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERA 25834 Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP-KL 607 + ++T+ T L N G ++ + +P G P+ P ++ Sbjct: 25835 RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP--GPPAGPLEI 25892 Query: 608 EGQMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSS-EW---KPEIRLPSGSDHVM 660 G E K +L Q+DGG+ I +Y+V R S W + E+++ S + Sbjct: 25893 NGLTAE-----KCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKL 25947 Query: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTS 707 LK EY V N+ G + V + P +P+ PTS Sbjct: 25948 LK----GNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPS--PPTS 25988 >gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo sapiens] Length = 1386 Score = 145 bits (365), Expect = 2e-34 Identities = 153/624 (24%), Positives = 239/624 (38%), Gaps = 70/624 (11%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANI-- 88 +S GE C+ G + +I W+ N R++ V D + L + + + Sbjct: 75 VSRGEPATLPCRAEGRPRP-NIEWYK--------NGARVATVREDPRAHRLLLPSGALFF 125 Query: 89 ----------DDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVI 137 D G+Y CV G+ + ++++ + F+ +P GE AV+ Sbjct: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185 Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196 C P P++ W+ G LK++ I + L + K+D G Y C +A Sbjct: 186 ECVPPRGHPEPSVSWRKDGAR--LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA- 242 Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256 GE +V+V P+ R VN VT +C+ +G P P + W K+ + Sbjct: 243 GERESAAAEVMVLERPSFLRRP--VNQVVLADAPVTFLCEVKGDPPPRLRWRKE----DG 296 Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316 E +Y D S L I V DE Y C+AEN G +A+ L V P++ Sbjct: 297 ELPTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSHARVSSLTLK 373 E V CE G+P P+I W+ + S+ G V + L + Sbjct: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ---LNIT 412 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426 ++Q DAG Y+C A + G LE++ A LQGP G+ V + C Sbjct: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 V P ++ W +DGQ L + + T + L + E D G Y+C A + G Sbjct: 473 RVTGNPQPSVRWKKDGQWLQGDDLQ----FKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528 Query: 487 QESLEFIL-------VQADTPSSPSIDQVEP-------YSSTAQVQFDEPEATGGVPILK 532 + + L V D P+ PS P + + +P G + Sbjct: 529 EATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588 Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 Y E + W + T+ GL+P T Y + A+ GL E S SE Sbjct: 589 YVIE---AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSE 645 Query: 593 -FKTQPVQGEPSAPKLEGQMGEDG 615 +TQ PS P + G+ G Sbjct: 646 PVRTQ--DSSPSRPVEDPWRGQQG 667 Score = 46.6 bits (109), Expect = 1e-04 Identities = 62/278 (22%), Positives = 103/278 (37%), Gaps = 31/278 (11%) Query: 306 AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365 A P+I + E TL C A G P P+I W + +++ + H ++ Sbjct: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121 Query: 366 RV--SSLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGN 420 + + D G Y C A N +G + S+ + V Q P V G Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181 Query: 421 QVNITC-EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479 + C +P ++SW +DG L I I L ++ ++D G Y C Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEE-GRITI----RGGKLMMSHTLKSDAGMYVC 236 Query: 480 TAVNRIGQE---SLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEP------EATG 526 A N G+ + E ++++ + ++QV P + +V+ D P + G Sbjct: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG 296 Query: 527 GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV 564 +P +Y+ HS W A EG T V Sbjct: 297 ELPTGRYEIRSD-------HSLWIGHVSAEDEGTYTCV 327 >gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42 precursor [Homo sapiens] Length = 2012 Score = 143 bits (361), Expect = 6e-34 Identities = 167/700 (23%), Positives = 289/700 (41%), Gaps = 43/700 (6%) Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84 S+ +S E +C V G I+W + L RIS + + + S L I Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPT-ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNIS 472 Query: 85 NANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVV 142 ++ + D G+Y+C G +A +NV+ + KN G D I C V+ Sbjct: 473 SSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA----GRDTYIHCRVI 528 Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARGEINF 201 +I W +K +++ + +N L++ ++K DEG Y C +L + +++ Sbjct: 529 GYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN--VLVQPQLST 585 Query: 202 -KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEP-TMSWTKDGEQIEQEED 259 + + V V VPP IQ + ++GQ V + C P T++W KDG I Sbjct: 586 SQSVHVTVKVPPFIQPFEF---PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLG 642 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 D +S L I + Y CIA N+A + L V PK Sbjct: 643 -VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDG 701 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--TLDGHMVVRSHARVSSLTLKSIQY 377 + V L C A G P+P+I W+ S + + L+G + V S+ SL +K + Sbjct: 702 IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLLIKHVVE 758 Query: 378 TDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSAT 435 D+G Y+C SN +G D S+SMYL V+ + P +G + ++C Sbjct: 759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPII 818 Query: 436 ISWFRDGQLLP---SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492 + W ++ +++ + + K S L++ P D G ++C A+N G++ Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878 Query: 493 ILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552 L + P P I+ + + T +++ G PI Y E + + W S Sbjct: 879 QLTVQEPPDPPEIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKSDS-WDSAQRTK 936 Query: 553 KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMG 612 + TI+ + P +TY++R+ A N +G+ ++E + P P E + Sbjct: 937 DVSPQLNSATIIDIHPSSTYSIRMYAKN--RIGKSEPSNELTITADEAAPDGPPQEVHLE 994 Query: 613 E-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPS-----GSDHVMLKSL 664 SI+V K+ IR Y + YR S+ + + S S+ L +L Sbjct: 995 PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNL 1054 Query: 665 DWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 702 + +Y + V A N+ G ++ + T+ + P+ P N Sbjct: 1055 NKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPEN 1094 Score = 102 bits (255), Expect = 1e-21 Identities = 94/408 (23%), Positives = 159/408 (38%), Gaps = 29/408 (7%) Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT------PQEFREGEDAVIVCD 140 N D Y+C+ E+ + + ++F +AP+ ++ G+ + C Sbjct: 188 NEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCK 247 Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195 + P W + L + V L I I+ +D G+Y CE G Sbjct: 248 ALGHPEPDYRWLKDNMPLELSGRFQKTVTG---LLIENIRPSDSGSYVCEVSNRYGTAKV 304 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 G + K + TI R+ +++G V+L C G + +SW ++GE + Sbjct: 305 IGRLYVKQ-----PLKATISPRK----VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC-IAENKAGEQDATIHLKVFAKPKITYVE 314 ++ I + L + + K+D Y C + ++K QD + PKI Sbjct: 356 PGKNVR--ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374 ++ + E V+L C G P+P+ITW I M+ VS L + S Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 473 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434 Q D G Y CTA+N+ G + V+ ++ + G I C V YP Sbjct: 474 SQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYY 533 Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 +I W+++ LLP N+ + N + +V E D G Y C + Sbjct: 534 SIKWYKNSNLLP-FNHRQVAFENNGTLKLSDV--QKEVDEGEYTCNVL 578 Score = 87.8 bits (216), Expect = 4e-17 Identities = 94/403 (23%), Positives = 143/403 (35%), Gaps = 21/403 (5%) Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153 Y C G V++K + + Q+ G AV C + SS+ I Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159 Query: 154 KGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDE-GTYRCEGRILARGEINFKDIQVIVNVP 211 +D + L RF++ S L I+ ++ D YRC R GE + + Sbjct: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219 Query: 212 PTIQARQ---NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268 P A + A GQ V L C A G PEP W KD +E +K + Sbjct: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---- 275 Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328 + L I+ + +D Y+C N+ G L V K T + + QV+L+ Sbjct: 276 -TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334 Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC--T 386 C +G ++W + ++ G V + +L + + +D G Y C Sbjct: 335 CSVTGTEDQELSWYRNGEILN------PGKNVRITGINHENLIMDHMVKSDGGAYQCFVR 388 Query: 387 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446 QD + LE + V++ C V P TI+W D + Sbjct: 389 KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL 448 Query: 447 SSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG 486 I T SYL ++ D G Y CTA N G Sbjct: 449 KGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491 Score = 79.3 bits (194), Expect = 1e-14 Identities = 152/704 (21%), Positives = 269/704 (38%), Gaps = 81/704 (11%) Query: 32 SVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA 91 S+G+ F C V I+W +G + P +++ N D +S+L I N ++ Sbjct: 608 SIGQRVFIPCVVVSGDLPITITW-QKDGRPI-PGSLGVTID-NIDFTSSLRISNLSLMHN 664 Query: 92 GIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 G Y C+ E + E ++ + V++ K + + P Q+ G+ ++ C PTI+ Sbjct: 665 GNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIV 722 Query: 151 WKH-KGRDVILKKDV----RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205 WK KG V + + R VLSN L I+ + + D G Y C+ +++ K + Sbjct: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVS-KSMY 781 Query: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DE 261 + V +P I + N AT GQ + C A G + W K+ I E Sbjct: 782 LTVKIPAMITSYPNTTLATQ--GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST 839 Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321 K + + S L I + D + C A N GE I L V P +E + Sbjct: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKAR 899 Query: 322 EEQVTLTCEASGD-PIPS--ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 + T G+ PI I + + + S ++T D +++S T+ I + Sbjct: 900 TITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKD------VSPQLNSATIIDIHPS 953 Query: 379 DAGEYICTASNTIGQDSQSMYLEV---QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435 A N IG+ S L + + AP +G + E + S Sbjct: 954 STYSIRMYAKNRIGKSEPSNELTITADEAAP-----------DGPPQEVHLEPISSQSIR 1002 Query: 436 ISWFRDGQLLPSSNYSNIKI----YNTP-SASYLEVTPDSENDFGNYNCTAVNRIGQESL 490 ++W + L + +I Y+T + + ++ D+ D Y +N+ Q L Sbjct: 1003 VTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGL 1062 Query: 491 EFILVQADTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPIL--KYKAEWRAVGEE---- 543 +VQA + E ++T + V PE + W + +E Sbjct: 1063 ---VVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNG 1119 Query: 544 -------VWHSKWYDAKEASMEGIVT------IVGLKPETTYAVRLAALNGKGLGEISAA 590 ++ + D + ++ I T + GL+ T Y++++ A G G S Sbjct: 1120 ILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQ 1179 Query: 591 SEFKT-QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV----RYRALSSE 645 +T + V G P+ K + + V+ + IR Y V Y + SE Sbjct: 1180 IFTRTKEDVPGPPAGVKAAAA---SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISE 1236 Query: 646 WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFV 689 ++ S + +L N +Y V+VVA G+ ++ + Sbjct: 1237 FEAS----PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276 Score = 79.3 bits (194), Expect = 1e-14 Identities = 95/365 (26%), Positives = 147/365 (40%), Gaps = 34/365 (9%) Query: 387 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWF 439 A + G+ + S + V+ P + P + T+ G + + C+ PS + W Sbjct: 1263 AVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320 Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADT 499 +D PS + + + S++ T +E D G Y+C A N G + + L Sbjct: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWGSDEIILNLQVQVP 1379 Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P P + + SS+ + + P GG I Y ++ E W S E S Sbjct: 1380 PDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR- 1437 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNS-I 618 + LK T Y L A NG G G IS E KT + EP K + + + Sbjct: 1438 ---LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKT--LGKEPQFSKEQELFASINTTRV 1492 Query: 619 KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 678 ++NLI +DGG PI + + YR + + S S +L L YE+ + N Sbjct: 1493 RLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN 1552 Query: 679 QQG-KSKAAHFV---FRTSAQPTAIPANGSPTSGLSTG-----------AIVGILIVIFV 723 G K A+F + S P I + GL+T +VG+L+ +FV Sbjct: 1553 SAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLL-LFV 1611 Query: 724 LLLVV 728 LLLVV Sbjct: 1612 LLLVV 1616 Score = 70.5 bits (171), Expect = 6e-12 Identities = 86/375 (22%), Positives = 139/375 (37%), Gaps = 68/375 (18%) Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQTAMEL 321 S DS I + +N + +A AG ++ T+ A +I Sbjct: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW 1299 Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381 + + L C+A GDP P++ W + S T+DG + S+ S +++++ D+G Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV-TIDGRRSIFSNG---SFIIRTVKAEDSG 1355 Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441 Y C A+N G D + L+VQ P +Q +T S T+SW Sbjct: 1356 YYSCIANNNWGSDEIILNLQVQVPP-------------DQPRLTVSKTTSSSITLSW--- 1399 Query: 442 GQLLPSSN-YSNIKIY-------NTPSASYLEVTPDSEN---------DFGNYNCTAVNR 484 LP N S+I+ Y N+ ++P + + + TA N Sbjct: 1400 ---LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456 Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKY 533 +G + I ++A T EP S Q F T GG PI + Sbjct: 1457 VGPGRISEI-IEAKTLGK------EPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSF 1509 Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593 E+R G VW + A+ S+ + L+ T Y +++ N G E A F Sbjct: 1510 TLEYRPFGTTVWTT----AQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQA--NF 1563 Query: 594 KTQPVQGEPSAPKLE 608 T G P ++ Sbjct: 1564 ATLNYDGSTIPPLIK 1578 Score = 45.4 bits (106), Expect = 2e-04 Identities = 32/108 (29%), Positives = 47/108 (43%), Gaps = 8/108 (7%) Query: 207 IVNVPPTIQARQNIVNATANLG----QSVTLVCDAEGFPEPTMSWTKD--GEQIEQEEDD 260 I+ V P +A I+ + + + + L C A G P P + W KD G D Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334 Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 + IFS+ S I+ V D Y CIA N G + ++L+V P Sbjct: 1335 RRSIFSNGS--FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380 Score = 35.0 bits (79), Expect = 0.29 Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 8/103 (7%) Query: 133 EDAVIVCDVVSSLPPTIIWKH--KGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190 +D V+ C V P + W G ++ D R + SN IR +K D G Y C Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC- 1359 Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233 +A N+ ++I+N+ + Q + + S+TL Sbjct: 1360 ---IANN--NWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITL 1397 >gi|110431348 deleted in colorectal carcinoma [Homo sapiens] Length = 1447 Score = 142 bits (357), Expect = 2e-33 Identities = 168/656 (25%), Positives = 258/656 (39%), Gaps = 77/656 (11%) Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLS 170 +K F L F + P+ G + ++ C S P I WK G + L D R LS Sbjct: 34 IKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS 93 Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225 N L I+ I K DEG Y+CE + G I + +V V P ++ V TA Sbjct: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESV--TA 151 Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285 +G +V L C+ G P PT+ W K+ + + D + + S L I ++ D Y Sbjct: 152 FMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLP-SGALQISRLQPGDIGIY 210 Query: 286 ICIAENKAGEQDAT-IHLKVFAKP----KITYVE---NQTAMELEEQVTLTCEASGDPIP 337 C A N A + +++ + P ++ +++ N A+E ++ V L C SG P P Sbjct: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPP 269 Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397 S TW I K S S+L + ++ D+G Y C + S S Sbjct: 270 SFTWLRGEEVIQLRSKKY-------SLLGGSNLLISNVTDDDSGMYTCVVTYKNENISAS 322 Query: 398 MYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456 L V P L P +Y +E + C V P T++W ++G ++ S+Y + Sbjct: 323 AELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY-----F 377 Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSI-----DQVE 509 S L + ++D G Y C A N G Q S + I+ + PSS + D V Sbjct: 378 QIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVP 437 Query: 510 PYSSTAQVQFD---EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGI------ 560 S+ V+ EA G + V+ S+ D +E ++ Sbjct: 438 VLVSSRFVRLSWRPPAEAKGNIQTF-----------TVFFSREGDNRERALNTTQPGSLQ 486 Query: 561 VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV 620 +T+ LKPE Y R+ A N G GE S + TQP P + + SI + Sbjct: 487 LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILI 546 Query: 621 NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 680 P++ Y + +S+ + I + S L+ L EY + +A N+ Sbjct: 547 TWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--YKLEGLKKFTEYSLRFLAYNRY 604 Query: 681 GKSKAAH--FVFRTSAQPTAIPANGS---------------PTSGLSTGAIVGILI 719 G + V S P+A P N S P SG G I G I Sbjct: 605 GPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660 Score = 103 bits (257), Expect = 7e-22 Identities = 146/622 (23%), Positives = 227/622 (36%), Gaps = 59/622 (9%) Query: 90 DAGIYKCVVT-GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPT 148 D G+Y+C + G+ GS T V + L F + G+ ++ C+V+ PT Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT 170 Query: 149 IIWKHKGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207 I W+ +D+ + D R +VL + LQI ++ D G YRC R A + +V Sbjct: 171 IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTG-NEAEVR 229 Query: 208 VNVPPTIQAR----QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263 + P + + Q N A G+ L C G+P P+ +W + GE++ Q + Sbjct: 230 ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS 288 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP-KITYVENQTAMELE 322 + S L I V +D Y C+ K A+ L V P + + N A E Sbjct: 289 LLG--GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYE-S 345 Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYT 378 + C SG P+P++ W +G +V+ S S+L + + + Sbjct: 346 MDIEFECTVSGKPVPTVNWMK------------NGDVVIPSDYFQIVGGSNLRILGVVKS 393 Query: 379 DAGEYICTASNTIGQDSQSMYLEV-----------QYAPKLQGPVAVYTWEGNQVNITCE 427 D G Y C A N G S L V AP+ PV V V ++ Sbjct: 394 DEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLV---SSRFVRLSWR 450 Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487 A I F N P + L V + A N G Sbjct: 451 PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGP 510 Query: 488 -ESLEFILV----QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542 ES + I V + P Q S T+ + EP A P+ Y+ V Sbjct: 511 GESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVST 570 Query: 543 EVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEP 602 + D +E GLK T Y++R A N G G + + + P Sbjct: 571 GKEQNIEVDGLSYKLE------GLKKFTEYSLRFLAYNRYGPG--VSTDDITVVTLSDVP 622 Query: 603 SAPKLEGQMG-EDGNSIKVNLIKQDDG--GSPIRHYLVRYRALSSEWKPEIRLPSGSDHV 659 SAP + + SIKV+ + G I Y +R+R + + E P+ + Sbjct: 623 SAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWY- 681 Query: 660 MLKSLDWNAEYEVYVVAENQQG 681 + L+ ++Y V A G Sbjct: 682 LFTGLEKGSQYSFQVSAMTVNG 703 Score = 60.8 bits (146), Expect = 5e-09 Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 26/256 (10%) Query: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138 S L I N DD+G+Y CVVT ++ + S A+ + + F N P+ E D Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENIS-ASAELTVLVPPWFLNHPSNLYAYESMDIEFE 351 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198 C V PT+ W G DV++ D F ++ + L+I G+ K+DEG Y+C +A E Sbjct: 352 CTVSGKPVPTVNWMKNG-DVVIPSDY-FQIVGGSNLRILGVVKSDEGFYQC----VAENE 405 Query: 199 INFKDIQVIVNVP-PTIQARQNIVNATANL------GQSVTL----VCDAEGFPEP-TMS 246 + VP P I + + +A ++ + V L +A+G + T+ Sbjct: 406 AGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 465 Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306 ++++G+ E+ + + S QLT+ + + +A N+ G +++ +KV Sbjct: 466 FSREGDNRERALNTTQ----PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521 Query: 307 KPKITY---VENQTAM 319 +P++ VEN A+ Sbjct: 522 QPELQVPGPVENLQAV 537 Score = 32.7 bits (73), Expect = 1.5 Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN-SIKVN 621 I+ L +T Y R+ A N KG+G +S F+T V+ +G+ G+ G + N Sbjct: 1009 IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTN 1068 Query: 622 LIKQDDGGSP 631 LI + P Sbjct: 1069 LIDRSTLNEP 1078 >gi|157311649 neogenin homolog 1 [Homo sapiens] Length = 1461 Score = 141 bits (355), Expect = 3e-33 Identities = 160/629 (25%), Positives = 253/629 (40%), Gaps = 72/629 (11%) Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170 +++ F F P G ++ C S P I WK G + L D R +L Sbjct: 46 SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105 Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225 + L I + K DEG Y+C + + G I + ++IV P ++ + A Sbjct: 106 DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165 Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285 G + L C+ P + W EQ Q + + S L I + D Y Sbjct: 166 --GNNAILNCEVNADLVPFVRW----EQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLY 219 Query: 286 ICIAENKA-GEQDATIHLKVFAKPKI----TYVENQTAM--ELEEQVTLTCEASGDPIPS 338 C+ E+ + + LKV P++ +++ + + + + V L C ASG P P+ Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279 Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398 I W + + +E +V+ + SL + + DAG Y C A N Sbjct: 280 IKWMKNEEALDTESSE---RLVLLAG---GSLEISDVTEDDAGTYFCIADNGNETIEAQA 333 Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL-LPSSNYSNIKIY 456 L VQ P+ L+ P +Y E + CEV P+ T+ W ++G + +PS + +K + Sbjct: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH 393 Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQ---ADTPSSPSIDQVEPY 511 N L+V ++D G Y C A N +G Q + I+++ A T PS + + Sbjct: 394 N------LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPR-DVV 446 Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAV-----GEEVWHSKWYDAKEASMEGI------ 560 +S +F K WR G+ + +S +Y + + E + Sbjct: 447 ASLVSTRF-------------IKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHP 493 Query: 561 ----VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VQGEPSAPKLEGQMGEDG 615 VTI L P T Y R+ A N G GE SA +TQP VQ AP L Sbjct: 494 GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP- 552 Query: 616 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675 SI V G I++Y + Y ++ + ++ + S S + L EY VV Sbjct: 553 TSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS--YTINGLKKYTEYSFRVV 610 Query: 676 AENQQGKSKAAHFV-FRT-SAQPTAIPAN 702 A N+ G + V RT S P+A P N Sbjct: 611 AYNKHGPGVSTPDVAVRTLSDVPSAAPQN 639 Score = 107 bits (267), Expect = 5e-23 Identities = 157/731 (21%), Positives = 268/731 (36%), Gaps = 103/731 (14%) Query: 10 TLFFLGTAVSLQVDIV----------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG 59 T+ LGT +S ++ P + G + C+V D + W N Sbjct: 132 TVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF-VRW-EQNR 189 Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG------EDGSESEATVNVK 113 + L + + I + S L I NA D G+Y+CVV D E + + + Sbjct: 190 QPLLLDDRVIKL-----PSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244 Query: 114 IFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNN 172 + L+F P+P G+D V+ C V S LP PTI W + + R ++L+ Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGG 303 Query: 173 YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232 L+I + + D GTY C +A + Q + V + + N A+ + Sbjct: 304 SLEISDVTEDDAGTYFC----IADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359 Query: 233 LVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK 292 C+ G P PT+ W K+G+ + + Y L + + K+DE Y CIAEN Sbjct: 360 FECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVKSDEGFYQCIAEND 415 Query: 293 AGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE 352 G A L + T +A + +TWRT + + Sbjct: 416 VGNAQAGAQLIILEHAPATTGPLPSAPR-----DVVASLVSTRFIKLTWRTPASDPHGDN 470 Query: 353 KTLD----------GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402 T + SH +T++++ + A N G S L V Sbjct: 471 LTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530 Query: 403 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 462 + P++Q P G N+ + S T++W + + + N K+Y Sbjct: 531 ETQPEVQLP-------GPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKLY------ 575 Query: 463 YLEVTPDSENDFG----NYNCTAVNRIGQESLEFILVQADTP--SSP--------SIDQV 508 Y+E D E D +Y + + + S + P S+P + Sbjct: 576 YMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSA 635 Query: 509 EPYSSTAQVQFDE---------PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P + + +V+ + AT I YK +R S+ D E + G Sbjct: 636 APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA------SRKSDVTETLVSG 689 Query: 560 I---VTIVGLKPETTYAVRLAALNGKGLGEIS---AASEFKTQPVQGEPSAPKLEGQMGE 613 I GL T Y R+AAL G G + +A F++ E P++ + Sbjct: 690 TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESD--LDETRVPEVPSSLHV 747 Query: 614 DG--NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYE 671 SI V+ ++ +R Y + Y + S I++ + +++LD ++ Y Sbjct: 748 RPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQRYYTIENLDPSSHYV 806 Query: 672 VYVVAENQQGK 682 + + A N G+ Sbjct: 807 ITLKAFNNVGE 817 >gi|109150416 peroxidasin [Homo sapiens] Length = 1479 Score = 140 bits (352), Expect = 6e-33 Identities = 112/384 (29%), Positives = 163/384 (42%), Gaps = 31/384 (8%) Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85 P +++ G + +F C+ G+ K +I W N E R++++ DD TL I N Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKP-EIIWLRNNNELSMKTDSRLNLL--DDG--TLMIQN 306 Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIF---QKLMFKNAPTPQEFREGEDAVIVCDVV 142 D GIY+C+ G V ++ F + F P E GE + C Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366 Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG--RILARGEIN 200 PP I W +G L D R + + L I+ + + D G Y C I + Sbjct: 367 GHPPPRISWT-RGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260 F +Q + T Q R I GQ+V C+A+G P P ++WTK G Q+ D Sbjct: 426 FIIVQALPQFTVTPQDRVVIE------GQTVDFQCEAKGNPPPVIAWTKGGSQLSV---D 476 Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTA 318 +++ S L I V +D+ +Y C A N G Q HL V + P + + T Sbjct: 477 RRHLVLS-SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 +E+ V L C + G+P P+ITW N + T G + LT+ + Sbjct: 536 VEVGANVQLPCSSQGEPEPAITW-----NKDGVQVTESGKFHISPEG---FLTINDVGPA 587 Query: 379 DAGEYICTASNTIGQDSQSMYLEV 402 DAG Y C A NTIG S SM L V Sbjct: 588 DAGRYECVARNTIGSASVSMVLSV 611 Score = 139 bits (350), Expect = 1e-32 Identities = 108/378 (28%), Positives = 161/378 (42%), Gaps = 27/378 (7%) Query: 124 PTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD 183 P + G C + P IIW ++ +K D R +L + L I+ ++TD Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311 Query: 184 EGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV----NATANLGQSVTLVCDAEG 239 +G Y+C + +A GE+ +++ + P AR V N +G+SVTL C A G Sbjct: 312 QGIYQCMAKNVA-GEVKTQEVTLRYFGSP---ARPTFVIQPQNTEVLVGESVTLECSATG 367 Query: 240 FPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDAT 299 P P +SWT+ G++ D I S L I+ V + D EY C A N AT Sbjct: 368 HPPPRISWTR-GDRTPLPVDPRVNI--TPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424 Query: 300 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359 + V A P+ T + + V CEA G+P P I W +S + + H+ Sbjct: 425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR----HL 480 Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ--YAPKLQGPVAVYTW 417 V+ S +L + + D G+Y C A N IG +L VQ P + T Sbjct: 481 VLSS----GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536 Query: 418 E-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476 E G V + C P I+W +DG + S K + +P +L + D G Sbjct: 537 EVGANVQLPCSSQGEPEPAITWNKDGVQVTESG----KFHISPE-GFLTINDVGPADAGR 591 Query: 477 YNCTAVNRIGQESLEFIL 494 Y C A N IG S+ +L Sbjct: 592 YECVARNTIGSASVSMVL 609 Score = 62.0 bits (149), Expect = 2e-09 Identities = 57/198 (28%), Positives = 82/198 (41%), Gaps = 18/198 (9%) Query: 307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR 366 +P+IT + V TC A G+P P I W + +S + D + + Sbjct: 245 RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMK---TDSRLNLLDD-- 299 Query: 367 VSSLTLKSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQYAPK----LQGPVAVYTWEGNQ 421 +L +++ Q TD G Y C A N G+ +Q + L +P + P G Sbjct: 300 -GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES 358 Query: 422 VNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480 V + C +P ISW R D LP NI TPS L + + D G Y C+ Sbjct: 359 VTLECSATGHPPPRISWTRGDRTPLPVDPRVNI----TPSGG-LYIQNVVQGDSGEYACS 413 Query: 481 AVNRIGQ-ESLEFILVQA 497 A N I + FI+VQA Sbjct: 414 ATNNIDSVHATAFIIVQA 431 >gi|222352127 sidekick 2 [Homo sapiens] Length = 2172 Score = 139 bits (349), Expect = 1e-32 Identities = 169/708 (23%), Positives = 283/708 (39%), Gaps = 70/708 (9%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 +S GE+ ++WF +G K+ P+ RI++ + TL I + D Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFR-DGRKIPPSS-RIAITLEN----TLVILSTVAPD 177 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA----------PTPQEFREGEDAVIVCD 140 AG Y + +++ + + + + + A P G V + Sbjct: 178 AGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC 237 Query: 141 VVSSLPPT---IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197 V ++ P IIWK G V+L + N L I +D G Y CE + + Sbjct: 238 VANARPLIKLHIIWKKDG--VLLSGGISD---HNRRLTIPNPTGSDAGYYECEAVLRSSS 292 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257 + + + P ++ + TA + + V + C A+G P P+++W KD +E E Sbjct: 293 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 352 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-KPKITYVENQ 316 + +D Q I + +D + C A N AGE + +L V + P IT Sbjct: 353 KLTRFRQRNDGGLQ--ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD 410 Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376 + + V L CE SG P P+ITW+ R ++S L + S SL + Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES----GSLLISPTH 466 Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSAT 435 +DAG Y C A+N+ G D S L V ++ P + +G Q ++ C V P T Sbjct: 467 ISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT 526 Query: 436 IS--WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493 I W +DG L + ++ I++ S L ++ D G Y C ++ G +S Sbjct: 527 IRYIWEKDGATLGTESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVISAGGNDSRSAH 583 Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT------GGVPILKY-------KAEWRAV 540 L P +P P ++ + V+ T G P+++Y A W + Sbjct: 584 LRVRQLPHAPE----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVL 639 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600 V D K S VT+ GL P +Y RL A+N G G+ S +E + P + Sbjct: 640 LASV------DPKATS----VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP 689 Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDG--GSPIRHYLVRY--RALSSEWKPEIRLPSGS 656 + P+ G SI + + ++ Y++RY L ++ + + Sbjct: 690 PTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADV 749 Query: 657 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 702 ++++L+ L YE+ V A N G + V + Q PT P N Sbjct: 750 NNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGN 797 Score = 112 bits (279), Expect = 2e-24 Identities = 157/643 (24%), Positives = 248/643 (38%), Gaps = 63/643 (9%) Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTI 149 AG Y+C+V G+ + V++ F+ Q GE AVI ++S P P + Sbjct: 86 AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE-INFKDIQVIV 208 W GR + R + N L I D G Y + G+ + I + V Sbjct: 146 TWFRDGRKI--PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203 Query: 209 N--------VPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQEE 258 + PTI + A + VTL C A P + + W KDG + Sbjct: 204 ENVGGPADPIAPTIIIPPKNTSVVAGTSE-VTLECVANARPLIKLHIIWKKDGVLLSGG- 261 Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPK-ITYVE 314 SD + +LTI +D Y C A ++ + + +L V P+ + E Sbjct: 262 ------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315 Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-VSSLTLK 373 E+E+ V + C+A G P PSITW + E+ T R R L + Sbjct: 316 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT-------RFRQRNDGGLQIS 368 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431 + D G + C A N G+ S YL V AP + +GP+ +G V + CE Sbjct: 369 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 428 Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESL 490 P I+W + ++L S + + S S L ++P +D G Y C A N G E+ Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEAS 487 Query: 491 EFILVQADT-----PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY--KAEWRAVGEE 543 ++V A T P S+ + S V D P T ++Y + + +G E Sbjct: 488 ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHD-PRVT-----IRYIWEKDGATLGTE 541 Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603 H + + S+ T G TY R+ + G S ++ + + + P Sbjct: 542 S-HPRIRLDRNGSLHISQTWSG--DIGTYTCRVISAGGND----SRSAHLRVRQLPHAPE 594 Query: 604 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-RLPSGSDHVMLK 662 P + + +I + K DG SP+ Y++ ++ W + + + V +K Sbjct: 595 HP-VATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK 653 Query: 663 SLDWNAEYEVYVVAENQQGK---SKAAHFVFRTSAQPTAIPAN 702 L Y+ + A N GK SK V PTA P N Sbjct: 654 GLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQN 696 Score = 67.8 bits (164), Expect = 4e-11 Identities = 142/616 (23%), Positives = 233/616 (37%), Gaps = 100/616 (16%) Query: 120 FKNAPT-PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLSNNYLQIR 177 FK P Q EG V+ C S P W H R++ + R+++ S Sbjct: 28 FKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS------- 80 Query: 178 GIKKTDEGTYRC-----EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232 + +T G YRC G +L R Q V V + + + + G++ Sbjct: 81 -LDRTHAGFYRCIVRNRMGALLQR--------QTEVQVAYMGSFEEGEKHQSVSHGEAAV 131 Query: 233 LVCD-AEGFPEPTMSWTKDGEQIEQEE------DDEKYIFS---DDSSQLTIKKV-DKND 281 + FP+P ++W +DG +I ++ I S D+ + ++ V DKN Sbjct: 132 IRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNG 191 Query: 282 E---AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338 + ++ I + G I + PK T V T+ +VTL C A+ P+ Sbjct: 192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS-----EVTLECVANARPLIK 246 Query: 339 --ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA---SNTIGQ 393 I W+ +S + H R LT+ + +DAG Y C A S+++ Sbjct: 247 LHIIWKKDGVLLSGG---------ISDHNR--RLTIPNPTGSDAGYYECEAVLRSSSVPS 295 Query: 394 DSQSMYLEVQYAPK-LQGPVAVYTWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYS 451 + YL V P+ ++ P T E + V+I C+ P +I+W++D ++ + Sbjct: 296 VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT 355 Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511 + N + PD D G + C A N G+ L A T +P+I + P Sbjct: 356 RFRQRNDGGLQISGLVPD---DTGMFQCFARNAAGEVQTSTYL--AVTSIAPNITR-GPL 409 Query: 512 SSTAQVQFDEPEA--TGGVP---ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL 566 ST A T G P I K E V ++ + S+ +++ + Sbjct: 410 DSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL--LISPTHI 467 Query: 567 KPETTYAVRLAALNGKGLGEISA-----ASEFKTQPVQGEPSAPKLEGQM---GEDGNSI 618 TY A N +G+ E SA A T+P Q + + M + Sbjct: 468 SDAGTYT--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV 525 Query: 619 KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP-SGSDHVMLKSLDWNAEYEVYVVAE 677 + I + DG + L +E P IRL +GS H+ S W+ + Y Sbjct: 526 TIRYIWEKDGAT-----------LGTESHPRIRLDRNGSLHI---SQTWSGDIGTYTCRV 571 Query: 678 NQQG--KSKAAHFVFR 691 G S++AH R Sbjct: 572 ISAGGNDSRSAHLRVR 587 Score = 45.1 bits (105), Expect = 3e-04 Identities = 43/161 (26%), Positives = 66/161 (40%), Gaps = 8/161 (4%) Query: 562 TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED--GNSIK 619 T GLKPE+ Y R+ A KG GE + A T+ + P P ED S+ Sbjct: 1361 TATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEK-RDRPQPPSRPMVQQEDVRARSVL 1419 Query: 620 VNLIKQDDGGSPIRHYLVRYRAL-SSEWK-PEIRLPSGSDHVMLKSLDWNAEYEVYVVAE 677 ++ DG SP+R+Y ++ R L S W + + ++ L Y+ V A Sbjct: 1420 LSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT 1479 Query: 678 NQQGK---SKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 715 N G S+ + + A P P S T +T ++ Sbjct: 1480 NDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLI 1520 Score = 37.4 bits (85), Expect = 0.059 Identities = 74/345 (21%), Positives = 123/345 (35%), Gaps = 32/345 (9%) Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-------AKPKITYVENQTAMELE 322 +Q + ++K+ E N GE ++ +VF A P+ V TA +L+ Sbjct: 1582 TQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLD 1641 Query: 323 ---EQVTLTCEASGD--PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377 E L + +GD W N++ KTL +S+ LK++ Sbjct: 1642 VTWEPPPLDSQ-NGDIQGYKIYFWEAQRGNLTERVKTL--------FLAENSVKLKNLTG 1692 Query: 378 TDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434 A A N G +S + Q AP V VN++ E +P+ Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752 Query: 435 TISWFR--DGQLLPSSNYSNIKIYNTPSAS--YLEVTPDSENDFGNYNCTAVNRIGQESL 490 + +R P S I + S +L+V +E + A + Sbjct: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812 Query: 491 EFILVQAD---TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547 E + P P + + YSS + + + G PI +Y E R E +W Sbjct: 1813 EANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKG-PITRYVIEARPSDEGLWDI 1871 Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592 D + ++ LKP +Y R+ A+N G G S+ S+ Sbjct: 1872 LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916 Score = 35.8 bits (81), Expect = 0.17 Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 5/129 (3%) Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568 E ++ +V + EP G+ + Y+ W Y ++E VT GL Sbjct: 905 EILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY-LPNVTLEYRVT--GLTA 960 Query: 569 ETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDG 628 TTY + +AA+ KG G++SA++ P + P P G S+ + DG Sbjct: 961 LTTYTIEVAAMTSKGQGQVSASTISSGVPPE-LPGPPTNLGISNIGPRSVTLQFRPGYDG 1019 Query: 629 GSPIRHYLV 637 + I +LV Sbjct: 1020 KTSISRWLV 1028 >gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] Length = 1215 Score = 139 bits (349), Expect = 1e-32 Identities = 130/491 (26%), Positives = 199/491 (40%), Gaps = 48/491 (9%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 ++VGE +C+ +G + I W+ E + + SS L I A D Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 642 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 AG Y C E G S A + + + P G A++ C PPT+ Sbjct: 643 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 701 Query: 151 WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205 W+ G+ + L+ + R + L + D+ Y CE R + G++ + Sbjct: 702 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 760 Query: 206 VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263 ++ + PP I + V GQ V+L C G P P W KDG + ++ Sbjct: 761 IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 815 Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323 D S L + + + Y C+A N AG Q + L V P+I Sbjct: 816 SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 874 Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383 +L C ASG P P+ITW T ++S H V ++ +L + DAG Y Sbjct: 875 PASLPCVASGVPAPTITWTKETNALTSRGP----HYNV---SKEGTLLIAQPSAQDAGAY 927 Query: 384 ICTASNTIGQDSQSMYLEVQYAPKL--------QGPVAVYTWEGNQVNITCEVFAYPSAT 435 +CTA+NT+G SQ M L V P++ P+ V G +V + CE P Sbjct: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987 Query: 436 ISWFRDGQLLP--SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493 ++W +D + +P ++ Y + PS S L + D G+Y CTA N G S ++ Sbjct: 988 VTWTKDSRPVPPITNRYGLL-----PSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYV 1041 Query: 494 L-VQADTPSSP 503 L VQ T P Sbjct: 1042 LGVQGRTSWQP 1052 Score = 133 bits (335), Expect = 6e-31 Identities = 174/706 (24%), Positives = 277/706 (39%), Gaps = 74/706 (10%) Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90 +S GE+ C+V G+A +++W + L + R++ + + +L I D Sbjct: 411 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 464 Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 G Y+CV + +G + A+V + + + + Q F +G + + C P I Sbjct: 465 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 523 Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208 W + + L++D R V + L I+G+ D G Y C+ A E+ + + + Sbjct: 524 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 577 Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267 PP++ A +V +G+ LVC+A G P P + W + G E I E Sbjct: 578 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 628 Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327 S +L I + D Y C A N+ G+ A I L V P++T + +EL L Sbjct: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688 Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386 C A+G P P++TWR L RS S L +S+ D Y+C Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746 Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442 A N G+ +++ + +AP V EG V++ C V A P W +DG Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806 Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502 + LP + +I+ + L + + G Y+C A N G + + LV Sbjct: 807 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV---VQVP 858 Query: 503 PSIDQVEPYSSTAQ-VQFDEPEATGGV--PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P I + T + V P GV P + + E A+ H S EG Sbjct: 859 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH------YNVSKEG 912 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP---VQGEPSAP---KLEGQMGE 613 + I + A A N G T+P + G +A ++ + GE Sbjct: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972 Query: 614 DGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIR----LPSGSDHVMLKSLDWNAE 669 + V L + G P LV + S P LPSGS + + + Sbjct: 973 E-----VTLDCEAKGSPP---PLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024 Query: 670 YEVYVVAENQQGKSKAAHFV---FRTSAQPTAIPANGSPT--SGLS 710 YE A N G + + + RTS QP ++P P SGLS Sbjct: 1025 YE--CTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLS 1068 Score = 107 bits (268), Expect = 4e-23 Identities = 90/366 (24%), Positives = 147/366 (40%), Gaps = 25/366 (6%) Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195 ++ C V S+LP + + + + L ++ F N+ +I K +EGTY C + Sbjct: 328 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 384 Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255 G K V+ + PP + N+ T + G++ L C G ++W +D + Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 441 Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315 + L I + D Y C+A N G A++ L V P+++ + Sbjct: 442 ASTGRVAQL---ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 498 Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375 +V ++C ASG P P I+W S E + L + A+ +L ++ + Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 550 Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSA 434 DAG Y C A+N +G D +++ L P + A V G + + CE P Sbjct: 551 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 610 Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494 + W+R G I S+ L + E D G Y C AVN +G S E L Sbjct: 611 RVIWYRGG-------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663 Query: 495 VQADTP 500 P Sbjct: 664 AVGHAP 669 Score = 89.0 bits (219), Expect = 2e-17 Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%) Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 +E++ +S I + K +E Y C A ++AG A + V P + Sbjct: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374 E L+C G+ ++TW D ++ S RV+ SL + Sbjct: 412 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 459 Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429 I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C Sbjct: 460 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 515 Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489 YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G + Sbjct: 516 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 570 Query: 490 LEFILVQADTPSSPSIDQV 508 L D PS +++ V Sbjct: 571 ETVTLYYTDPPSVSAVNAV 589 Score = 43.5 bits (101), Expect = 8e-04 Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%) Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 426 SS + + G Y CTA + G + V P P T G ++C Sbjct: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 421 Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486 V ++W RD ++LP+S ++ + LE++ D G Y C A N G Sbjct: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 477 Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546 L+ + P + +S +V+ + P + + E +A+ E+ Sbjct: 478 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 534 Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597 +G + I G+ PE A N G + + + P Sbjct: 535 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581 >gi|142976733 surface glycoprotein, Ig superfamily member [Homo sapiens] Length = 1264 Score = 137 bits (346), Expect = 3e-32 Identities = 168/711 (23%), Positives = 276/711 (38%), Gaps = 117/711 (16%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109 ISW NG+ L N + + + TLTI + N G Y+C+ G+ AT Sbjct: 59 ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112 Query: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166 V+V + K+ T +E G I C V S P + ++K R L+ + Sbjct: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168 Query: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221 ++L + LQI + D+G+Y+C ++ + I +++V+ P + Sbjct: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228 Query: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280 A A L +S VTL C G P P + W KDG+ I + + S L VD Sbjct: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283 Query: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339 D Y C+A NK+G+ + T + V I+ + L V TC+ G+P P+ Sbjct: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343 Query: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY 399 TW + + I + H+ + ++S +T++ D G Y C A N IG + Sbjct: 344 TWFHNAQPIHPSAR----HLTAGNGLKISGVTVE-----DVGMYQCVADNGIGFMHSTGR 394 Query: 400 LEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS------- 447 LE++ + P + PV+ +G+ V ++C P I W+ L+ S Sbjct: 395 LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLR 454 Query: 448 --SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493 S S + + + AS L + ++ G Y C A N G E Sbjct: 455 SKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEAS 514 Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553 L+ V P+ + KAE + + + + Sbjct: 515 LM------------VVPFETNT------------------KAETVTLPDAAQNDD-RSKR 543 Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE 613 + S G+++ +K + N G+ + A + P P L + G+ Sbjct: 544 DGSETGLLSSFPVKVHPSAVESAPEKNASGI-SVPDAPIILSPPQTHTPDTYNLVWRAGK 602 Query: 614 DGNSIKVNLIKQDDGGSPIRHYLVRYRALS------SEWKPEIRLPSGSDHVMLKSLDWN 667 DGG PI Y V+YR L W +R+P + + L L+ + Sbjct: 603 -------------DGGLPINAYFVKYRKLDDGVGMLGSWH-TVRVPGSENELHLAELEPS 648 Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN---GSPTSGLSTGAIV 715 + YEV +VA + G+ + A FRTS + TA N SP G+ +V Sbjct: 649 SLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVV 699 Score = 53.1 bits (126), Expect = 1e-06 Identities = 61/277 (22%), Positives = 110/277 (39%), Gaps = 43/277 (15%) Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 P +P + S T+ P A GG PI +K E++ + W D + + Sbjct: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAAS----------EFKTQPVQGEPSAPKLEG 609 V + L+P +TY R+ A+N G S+AS F ++P+ G P E Sbjct: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG-PHIAYTEA 837 Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL----SSEWKPEIRLPSGSDHVMLKSLD 665 + + +K I + +PI+ + + YR S++K ++ S H M+ L Sbjct: 838 -VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWH-MIGHLQ 895 Query: 666 WNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTG------------- 712 Y++ + N+ G+S+ ++ + + A+ P LST Sbjct: 896 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPA 955 Query: 713 -----------AIVGILIVIFVLLLVVVDITCYFLNK 738 IVG ++ + VL+L+V C + N+ Sbjct: 956 TSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNR 992 >gi|119220552 sidekick 1 [Homo sapiens] Length = 2213 Score = 137 bits (344), Expect = 5e-32 Identities = 167/686 (24%), Positives = 267/686 (38%), Gaps = 68/686 (9%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 ++WF G K+ P+ RI++ + L I DAG Y E E++ + Sbjct: 223 VTWFR-EGHKIIPSN-RIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGENKTSPF 276 Query: 112 VKIFQKLMFKNAPTPQEFRE------GEDAVIV------CDVVSSLPP----TIIWKHKG 155 + + + ++ TP+ G +V+ + ++S P ++ WK G Sbjct: 277 IHLS---IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG 333 Query: 156 RDVI--LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPT 213 + L R + +SN D G Y CE + + + + P Sbjct: 334 VRITSGLHSFGRRLTISNP-------TSADTGPYVCEAALPGSAFEPARATAFLFIIEPP 386 Query: 214 IQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273 + +A + ++V + C A G P PT+ W KD I + ++ + + S L Sbjct: 387 YFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA--SGGLR 444 Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPKITYVENQTAMELEEQVTLTCEAS 332 I+K+ D + C A N+ GE +L V P T T + L CE S Sbjct: 445 IQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVS 504 Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392 G P P+ITW+ ++S + M++ S L + + DAG Y C A+NT G Sbjct: 505 GAPKPAITWKRENHILASGSVRIPRFMLLES----GGLQIAPVFIQDAGNYTCYAANTEG 560 Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS--WFRDGQLLPSSN 449 + S L V + P + +G + C P ++ W +D L S+ Sbjct: 561 SLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS 620 Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE 509 S I + S L ++ D G+Y+C V+ G +S L + P SP V Sbjct: 621 TSRIVVEKDGS---LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677 Query: 510 PYSSTAQV-------QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562 P SS + FD G PIL Y E + W + M G VT Sbjct: 678 PNSSHSHAVVLSWVRPFD-----GNSPILYYIVEL-SENNSPWKVHLSNVGP-EMTG-VT 729 Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNL 622 + GL P TY R+ A+N G G+ SA + P + + PK G SI V Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789 Query: 623 --IKQDDGGSPIRHYLVRYR--ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 678 + + +R Y++RYR L E++ ++ ++ L +YE+ V A N Sbjct: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYN 849 Query: 679 QQGKSKAAHFVFRTSAQ--PTAIPAN 702 G + V + Q PTA P N Sbjct: 850 GAGLGVFSRAVTEYTLQGVPTAPPQN 875 Score = 111 bits (278), Expect = 2e-24 Identities = 150/656 (22%), Positives = 255/656 (38%), Gaps = 62/656 (9%) Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PT 148 DAG Y+CVV G+ + V++ F + + +G A++ ++S P P Sbjct: 163 DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222 Query: 149 IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN-------- 200 + W +G +I R + N L I +D G Y + GE Sbjct: 223 VTWFREGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280 Query: 201 -FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQE 257 +D+ + PTI + A ++ TL C A P + +++W ++G +I Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSET-TLECIASARPVEDLSVTWKRNGVRITSG 339 Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKIT-YV 313 +LTI D Y+C A + AT L + P T Sbjct: 340 -------LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP 392 Query: 314 ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK 373 E++ + E+EE V + C+A G P+P++ W +IS + + V+ S L ++ Sbjct: 393 ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQN--PRYKVLAS----GGLRIQ 446 Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431 ++ D+G + C ASN G+ YL+V AP Q PV +G + CEV Sbjct: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506 Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491 P I+W R+ +L S + I + + L++ P D GNY C A N G + Sbjct: 507 PKPAITWKRENHILASGSV-RIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNAS 565 Query: 492 FILVQADTPS--SPSIDQVEPYSSTAQVQ---FDEPEATGGVPILKYKAEWRAVGEEVWH 546 L + S P D V +TA + +P + L+Y VW Sbjct: 566 ATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVS-----LRY----------VWK 610 Query: 547 SKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSA 604 +S IV L T++ + + + + E S V P + Sbjct: 611 KDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHS 670 Query: 605 PK--LEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-RLPSGSDHVML 661 P+ L +++ ++ ++ DG SPI +Y+V +S WK + + V + Sbjct: 671 PQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTV 730 Query: 662 KSLDWNAEYEVYVVAENQQGKSKAAHFVFR--TSAQPTAIPANGSPTSGLSTGAIV 715 L Y+ V A N+ G+ + + R +P + P SG + +I+ Sbjct: 731 SGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIM 786 Score = 43.5 bits (101), Expect = 8e-04 Identities = 48/202 (23%), Positives = 83/202 (41%), Gaps = 11/202 (5%) Query: 513 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 572 ++ ++ + PE G+ IL Y+ +R + + T L PE+ Y Sbjct: 1392 TSVRIVWQPPEEPNGI-ILGYQIAYRLASSSPHTFTTVEVGATVRQ--FTATDLAPESAY 1448 Query: 573 AVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK--LEGQMGEDGNSIKVNLIKQDDGGS 630 RL+A +G GE A+ T+ + P+ P+ L Q S+++ + DG S Sbjct: 1449 IFRLSAKTRQGWGEPLEATVITTEKRE-RPAPPRELLVPQAEVTARSLRLQWVPGSDGAS 1507 Query: 631 PIRHYLVRYRAL-SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHF 688 PIR++ ++ R L EW+ + + ++ L Y++ + A N G S F Sbjct: 1508 PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDS---DF 1564 Query: 689 VFRTSAQPTAIPANGSPTSGLS 710 T A T G P +S Sbjct: 1565 SSETEAVTTLQDVPGEPPGSVS 1586 Score = 40.8 bits (94), Expect = 0.005 Identities = 58/281 (20%), Positives = 103/281 (36%), Gaps = 62/281 (22%) Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287 G + L C AEG W +D ++ + KYI I + K D Y C Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI---------IPSLQKLDAGFYRC 169 Query: 288 IAENKAGEQDATIHLKVFAKPKITYV-------ENQTAMELEEQVTLTCEASGDPIPSIT 340 + N+ G A + K ++ ++ Y+ + +T + + + P P +T Sbjct: 170 VVRNRMG---ALLQRK--SEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVT 224 Query: 341 WRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYTDAGEYICTASN-TIGQDS 395 W +GH ++ S+ + L + + +DAG Y A N G++ Sbjct: 225 W------------FREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENK 272 Query: 396 QSMYLEVQYA-----PKLQGPVAVYTWEGN--------QVNITCEVFAYP--SATISWFR 440 S ++ + A P+ P V GN + + C A P +++W R Sbjct: 273 TSPFIHLSIARDVGTPETMAPTIVVP-PGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331 Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 +G + S +S L ++ + D G Y C A Sbjct: 332 NGVRITSGLHS--------FGRRLTISNPTSADTGPYVCEA 364 Score = 33.5 bits (75), Expect = 0.85 Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 1/93 (1%) Query: 499 TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558 +P SP V +S +Q+ E + G P Y E R E +W D ++ Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEGHS-GDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960 Query: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591 +++ L+ TY R+ A+N G GE S S Sbjct: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993 >gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo sapiens] Length = 1183 Score = 130 bits (326), Expect = 7e-30 Identities = 130/506 (25%), Positives = 203/506 (40%), Gaps = 36/506 (7%) Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181 NA +E R G + C + LP II+ K D +L K+ LQI + + Sbjct: 270 NASNKEELR-GNVLSLEC-IAEGLPTPIIYWAK-EDGMLPKNRTVYKNFEKTLQIIHVSE 326 Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241 D G Y+C + A G I+ + P I A QN+V + G+ TL+C A G P Sbjct: 327 ADSGNYQCIAK-NALGAIHHTISVRVKAAPYWITAPQNLV---LSPGEDGTLICRANGNP 382 Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301 +P +SW +G IE DD D+ + V + A Y C A N+ G A Sbjct: 383 KPRISWLTNGVPIEIAPDDPSRKIDGDT--IIFSNVQERSSAVYQCNASNEYGYLLANAF 440 Query: 302 LKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359 + V A+P T ++ L C G P+P+I W + + E H Sbjct: 441 VNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH- 499 Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWE 418 +L + Q G Y C A N +G ++LE++ + + P Sbjct: 500 ------ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553 Query: 419 GNQVNITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476 G+ V+ C+V S T+ W +D + LPS T +L V S++D G Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERF------TVDKDHLVVADVSDDDSGT 607 Query: 477 YNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 535 Y C A + S +L D P+ P ++ + + Q+ + P PI K+ Sbjct: 608 YTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSW-TPGDDNNSPITKFII 666 Query: 536 EWRAVGEEVWHSK--WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE- 592 E+ E+ H W+ E S + L P Y+ R+ A+N G S ASE Sbjct: 667 EY----EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQ 722 Query: 593 FKTQPVQGEPSAPKLEGQMGEDGNSI 618 + T+ + + + +EG E N + Sbjct: 723 YLTKASEPDKNPTAVEGLGSEPDNLV 748 Score = 107 bits (266), Expect = 6e-23 Identities = 153/671 (22%), Positives = 243/671 (36%), Gaps = 89/671 (13%) Query: 92 GIYKCVVTGEDGSESEATVNVKIFQK-LMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150 G+Y+C E G+ + V+ + L K P + G+ V+ C LPP II Sbjct: 113 GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPII 172 Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD-EGTYRCEGR------ILARGEINFKD 203 + L + R N L + D Y C R I + I+ K Sbjct: 173 FWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232 Query: 204 IQV-------IVNV--------------PPTIQARQ-NIVNATANLGQSVTLVCDAEGFP 241 I V N+ PPT + N N G ++L C AEG P Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292 Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301 P + W K+ + + + ++ + L I V + D Y CIA+N G TI Sbjct: 293 TPIIYWAKEDGMLPKN----RTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTIS 348 Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI----SSEEKTLDG 357 ++V A P + E TL C A+G+P P I+W T+ I + +DG Sbjct: 349 VRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDG 408 Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPV-AVY 415 ++ S ++Q + Y C ASN G + ++ V P++ P +Y Sbjct: 409 DTIIFS----------NVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLY 458 Query: 416 TWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474 N+ + C F P TI WF+ + + + IY LE+ ++ Sbjct: 459 QVIANRPALLDCAFFGSPLPTIEWFKGAK----GSALHEDIYVLHENGTLEIPVAQKDST 514 Query: 475 GNYNCTAVNRIGQESLEFILVQAD------TPSSPSIDQVEPYSSTAQVQFDEPEATGGV 528 G Y C A N++G E L D P + + S +V+ D Sbjct: 515 GTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDH------- 567 Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588 L W E+ + + + + +V V TY + L +S Sbjct: 568 -TLSLTVLWLKDNRELPSDERFTVDKDHL--VVADVSDDDSGTY----TCVANTTLDSVS 620 Query: 589 AASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--- 645 A++ V P +L Q+ + S++++ DD SPI +++ Y + Sbjct: 621 ASAVLSVVDVPNPPFDLELTDQLDK---SVQLSWTPGDDNNSPITKFIIEYEDAMHKPGL 677 Query: 646 WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS--KAAHFVFRTSA-----QPTA 698 W + + SG+ L Y V+A N GKS A + T A PTA Sbjct: 678 WHHQTEV-SGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTA 736 Query: 699 IPANGSPTSGL 709 + GS L Sbjct: 737 VEGLGSEPDNL 747 Score = 97.4 bits (241), Expect = 5e-20 Identities = 145/675 (21%), Positives = 244/675 (36%), Gaps = 108/675 (16%) Query: 80 TLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139 TL I + + D+G Y+C+ G+ T++V++ + AP GED ++C Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALGAIHH-TISVRVKAAPYWITAPQNLVLSPGEDGTLIC 376 Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRIL 194 + P I W G + + D + + + +++ Y+C G +L Sbjct: 377 RANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLL 436 Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254 A +N V+ P + + AN + L C G P PT+ W K + Sbjct: 437 ANAFVN-----VLAEPPRILTPANTLYQVIAN--RPALLDCAFFGSPLPTIEWFKGAKGS 489 Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314 ED Y+ ++ + L I K+ Y C+A NK G +HL++ I Sbjct: 490 ALHEDI--YVLHENGT-LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQP 546 Query: 315 NQTAMELEEQVTLTCEASGDPIPSIT--WRTSTRNISSEEKTLDGHMVVRSHARVSSLTL 372 ++ V+ C+ D S+T W R + S+E+ V + H L + Sbjct: 547 EYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDER----FTVDKDH-----LVV 597 Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTWEGNQV 422 + D+G Y C A+ T+ S S L V P +L V + G+ Sbjct: 598 ADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDN 657 Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482 N F I + D P + ++ T + + L+++P F AV Sbjct: 658 NSPITKF------IIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSF---RVMAV 708 Query: 483 NRIGQ----ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGV----PILKYK 534 N IG+ E+ E L +A P + VE S + G P L+YK Sbjct: 709 NSIGKSLPSEASEQYLTKASEPDK-NPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYK 767 Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594 WR ++ +W A++ + + G Y +++ ALN G Sbjct: 768 VSWR---QKDGDDEWTSVVVANVSKYI-VSGTPTFVPYLIKVQALNDMGFA--------- 814 Query: 595 TQPVQGEPSAPKLEGQMGED-----GNSIKVNLIKQDDGG--------SPIRHYLVRYRA 641 P + G GED +++VN++ IR +L YR Sbjct: 815 -------PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRI 867 Query: 642 LSSEWKPE--------------IRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA- 686 WK + + H ML L+ + Y + V N +G+ A+ Sbjct: 868 Y--YWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASP 925 Query: 687 HFVFRTSAQPTAIPA 701 VF T P +P+ Sbjct: 926 DRVFNT---PEGVPS 937 Score = 62.4 bits (150), Expect = 2e-09 Identities = 92/410 (22%), Positives = 147/410 (35%), Gaps = 59/410 (14%) Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN-----YLQIRGIKKTDEGTY 187 E+ VI C+ PP+ W G + KD + + G +T EG Y Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 115 Query: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE-GFPEPTMS 246 +C R RG +I V + P + ++ + T GQS+ L C G P P + Sbjct: 116 QCTAR-NERGAAVSNNIVVRPSRSP-LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF 173 Query: 247 WTKDG-EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE-YICIA---ENKAGEQDATIH 301 W + +++ Q E + + D L V D E YIC A + +Q I Sbjct: 174 WMDNSFQRLPQSERVSQGLNGD----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPIS 229 Query: 302 LKVFA-------------------------KPKITYVENQTAMELEE----QVTLTCEAS 332 +KV + +P A EE ++L C A Sbjct: 230 VKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE 289 Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392 G P P I W + E+ L + V + +L + + D+G Y C A N +G Sbjct: 290 GLPTPIIYW-------AKEDGMLPKNRTVYKNFE-KTLQIIHVSEADSGNYQCIAKNALG 341 Query: 393 QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451 ++ + V+ AP + P + G + C P ISW +G + + Sbjct: 342 AIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD 401 Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTP 500 + + + + V E Y C A N G + F+ V A+ P Sbjct: 402 PSRKIDGDTIIFSNV---QERSSAVYQCNASNEYGYLLANAFVNVLAEPP 448 Score = 52.8 bits (125), Expect = 1e-06 Identities = 74/324 (22%), Positives = 124/324 (38%), Gaps = 69/324 (21%) Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270 PPTI +Q+ + + +++ + C+A+G P P+ SWT++G + ++ D + Sbjct: 39 PPTI-TQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK-DPLVTMKPGTG 96 Query: 271 QLTIKKVDKND----EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-----L 321 L I + + E Y C A N+ G A + + +P + + + +E Sbjct: 97 TLIINIMSEGKAETYEGVYQCTARNERG---AAVSNNIVVRPSRSPLWTKEKLEPITLQS 153 Query: 322 EEQVTLTCEAS-GDPIPSITWR-TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 + + L C G P P I W S + + E+ S L ++ D Sbjct: 154 GQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERV--------SQGLNGDLYFSNVLPED 205 Query: 380 AGE-YICTA----SNTIGQDSQSMYLEVQYAPKLQGPVAV-------------------- 414 E YIC A + TI Q Q + ++V +L +A Sbjct: 206 TREDYICYARFNHTQTI-QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF 264 Query: 415 YTWEGNQVN----------ITCEVFAYPSATISWFRDGQLLPSSN--YSNIKIYNTPSAS 462 T EGN N + C P+ I W ++ +LP + Y N + Sbjct: 265 LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-------K 317 Query: 463 YLEVTPDSENDFGNYNCTAVNRIG 486 L++ SE D GNY C A N +G Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALG 341 >gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sapiens] Length = 2113 Score = 130 bits (326), Expect = 7e-30 Identities = 163/722 (22%), Positives = 287/722 (39%), Gaps = 60/722 (8%) Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84 S+ ++ GE +C G A ++W + + R + D + S + + Sbjct: 475 SEKVVNPGEQFSLMCAAKG-APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVT 533 Query: 85 NANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIV 138 I D G+Y+C GS E +A +NV+ P+ + R G D +I Sbjct: 534 GPQIRDGGVYRCTARNLVGSAEYQARINVR--------GPPSIRAMRNITAVAGRDTLIN 585 Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARG 197 C V+ +I W ++L + R +V N L++ ++K DEG Y C I + Sbjct: 586 CRVIGYPYYSIKWYKDA--LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643 Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT-MSWTKDGEQIEQ 256 I+ + + V V VPP IQ + A++GQ + + C P ++W KDG+ I Sbjct: 644 SIS-QSVHVAVKVPPLIQPFEF---PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699 Query: 257 EE----DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312 + ++++ S L I V Y CIA N A L V P+ Sbjct: 700 GSGVTIESKEFM-----SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754 Query: 313 VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGHMVVRSHARVSS 369 N + L C G P P + W+ + + + ++ L G + + + SS Sbjct: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN---SS 811 Query: 370 LTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCE 427 L ++ + D G Y+C ASN +G D S+SM+L V+ + P +G+ + C Sbjct: 812 LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCT 871 Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS----ASYLEVTPDSENDFGNYNCTAVN 483 I W + ++ I + S L++ P D ++C A+N Sbjct: 872 ARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAIN 931 Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543 G++ L + P P ++ E + + +++ + G I + E++ + Sbjct: 932 SYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDS 990 Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603 W K + IV L P + Y++R+ + N G E S T+ + P Sbjct: 991 -WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE--EAAPD 1047 Query: 604 APKLEGQMGE-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWK-----PEIRLPSG 655 P ++ + SI+V K++ IR Y + YR S E++ Sbjct: 1048 GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD 1107 Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPANGSPTSGLSTGA 713 S+ L +L A+Y V V A N+ G ++ + T+ + P+ P N S S A Sbjct: 1108 SEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVA 1167 Query: 714 IV 715 ++ Sbjct: 1168 VI 1169 Score = 108 bits (270), Expect = 2e-23 Identities = 121/509 (23%), Positives = 197/509 (38%), Gaps = 54/509 (10%) Query: 66 QQRISVV-WNDDSSSTLT-----------IYNANI---DDAGIYKCVVTGEDGSESEATV 110 Q+ +SVV W D+ S + +Y +++ D Y+C+ + E+ + Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272 Query: 111 NVKIFQKLMFKNAPT------PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164 ++ ++ PT QE G + C P I W GR L D Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--LPADS 330 Query: 165 RFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQN 219 R+ L I ++ D GTY CE G A G + D + P ++ Sbjct: 331 RWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT--- 386 Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279 +G +V L C G PE T+ W ++ E + +E S+++ L I K Sbjct: 387 ------GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET--LLITSAQK 438 Query: 280 NDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338 + Y C A KA QD I P+I ++ + EQ +L C A G P P+ Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498 Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398 +TW I + + +S + + Q D G Y CTA N +G Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558 Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNT 458 + V+ P ++ + G I C V YP +I W++D LLP N+ + N Sbjct: 559 RINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFEN- 616 Query: 459 PSASYLEVTPDSEN-DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE-PYSSTAQ 516 L++T + D G Y C+ + + + + V P P I E P +S Q Sbjct: 617 ---GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP--PLIQPFEFPPASIGQ 671 Query: 517 VQFDE-PEATGGVPILKYKAEWRAVGEEV 544 + + ++G +PI + WR G+ + Sbjct: 672 LLYIPCVVSSGDMPI---RITWRKDGQVI 697 Score = 80.9 bits (198), Expect = 5e-15 Identities = 154/673 (22%), Positives = 254/673 (37%), Gaps = 80/673 (11%) Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIVCDVVSS 144 D G Y C V + +V+V + K P Q F G+ I C V S Sbjct: 629 DEGEYLCSVLIQPQLSISQSVHVAV------KVPPLIQPFEFPPASIGQLLYIPCVVSSG 682 Query: 145 -LPPTIIWKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEIN 200 +P I W+ G+ +I V + S + LQI + G Y C A Sbjct: 683 DMPIRITWRKDGQVIISGSGVT--IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS- 739 Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260 ++ Q+IV VPP + N N G++ L C +G+P P + W + + + Sbjct: 740 -RERQLIVRVPPRFVVQPN--NQDGIYGKAGVLNCSVDGYPPPKVMW----KHAKGSGNP 792 Query: 261 EKY--------IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQ-DATIHLKVFAKPKIT 311 ++Y I +S L I+ V + D Y+C A N G ++ L V IT Sbjct: 793 QQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT 852 Query: 312 YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR--VSS 369 N T L C A G+ I W + ++ + + + + VS+ Sbjct: 853 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGD-TVIDPDRVMRYAIATKDNGDEVVST 911 Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYT--W 417 L LK D+ + C A N+ G+D + L VQ P K + +T + Sbjct: 912 LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971 Query: 418 EGNQVNITCEVFAYPSATISW-FRDG--QLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474 +GN + IT Y + + SW F+ + P+ N +NI +++ P S Sbjct: 972 DGNSI-ITGFDIEYKNKSDSWDFKQSTRNISPTINQANI----------VDLHPASVYSI 1020 Query: 475 GNYNCTAVNRIGQESLEFILVQADTPSSPSID-QVEPYSSTA-QVQFDEP--EATGGVPI 530 Y+ + R I + P P +D ++P +S + QV + P E GV I Sbjct: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGV-I 1079 Query: 531 LKYKAEWR--AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588 Y+ +R + G +S + K + T+ LK Y V + A N G G S Sbjct: 1080 RGYQIGYRENSPGSNGQYSI-VEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS 1138 Query: 589 AASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL------ 642 SE ++ PS P + + + V + + S + L YR + Sbjct: 1139 --SEINATTLEDVPSQPPENVRALSITSDVAV-ISWSEPPRSTLNGVLKGYRVIFWSLYV 1195 Query: 643 SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702 EW + + + V L+ ++ Y V V+A Q G + ++ + + P Sbjct: 1196 DGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPA 1255 Query: 703 GSPTSGLSTGAIV 715 G S ++V Sbjct: 1256 GIKAVPSSASSVV 1268 Score = 71.2 bits (173), Expect = 4e-12 Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 55/319 (17%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382 + V L C + GDP P++ W + + S+ ++DGH ++ ++ +L L++++ D+G Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSED-SAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGY 1420 Query: 383 YICTASNTIGQDSQSMYLEVQYAP--------KLQGPVAVYTW---EGNQVNITCEVFAY 431 Y CTA+NT G D+ + L VQ P K TW + +I V Y Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY 1480 Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491 ++D + SS+ + K+ + ++ +V ++N G+ RI + Sbjct: 1481 SVDNSEEWKD--VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS------GRISE---- 1528 Query: 492 FILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKYKAEWRAV 540 +++A T EP S Q F +T GG PI E+R Sbjct: 1529 --IIEAKTHGR------EPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPK 1580 Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600 G W A+ G V + L+ T Y +R+ A N G G +A +F T G Sbjct: 1581 GTWAW-----QGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETA--QFATLDYDG 1633 Query: 601 EPSAPKLEGQMGEDGNSIK 619 + P ++ GE G+ +K Sbjct: 1634 S-TIPPIKSAQGE-GDDVK 1650 Score = 63.9 bits (154), Expect = 6e-10 Identities = 86/354 (24%), Positives = 137/354 (38%), Gaps = 31/354 (8%) Query: 392 GQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWFRDGQ- 443 G S+ + +E P + P + ++ G V + C P+ + W +D + Sbjct: 1334 GNSSEKVTIE----PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED 1389 Query: 444 -LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502 +P S + I+ + V + D G Y CTA N G +++ L+ P Sbjct: 1390 SAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYYTCTATNTGGFDTIIVNLLVQVPPDQ 1446 Query: 503 PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562 P + + +S+ + + P GG I + ++ E W + + E S + Sbjct: 1447 PRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFK---- 1501 Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVN 621 + LK T Y V+LAA N G G IS E KT EPS K + + ++N Sbjct: 1502 LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTH--GREPSFSKDQHLFTHINSTHARLN 1559 Query: 622 LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681 L ++GG PI ++ YR W + + S V L L YE+ + A N G Sbjct: 1560 LQGWNNGGCPITAIVLEYRP-KGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618 Query: 682 -KSKAAHFVFRTSAQPTAIP-----ANGSPTSGLSTGAIVGILIVIFVLLLVVV 729 ++ A F T P G L T IL + V LL +V Sbjct: 1619 CGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIV 1672 Score = 56.2 bits (134), Expect = 1e-07 Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 33/298 (11%) Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSW-TKDGEQIEQEEDDEKYIFSDDSSQLTIKKV 277 ++ T + V + C A G P + W G+ I + +++ ++ + QL Sbjct: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDI-YDVPHIRHVHANGTLQLYPFSP 149 Query: 278 DKND----EAEYICIAENKAGE-QDATIHLK-VFAKPKITYVENQTAMELEEQV--TLTC 329 + + +Y C AEN AG+ + I +K VF +P VE+Q +M V L Sbjct: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIP 209 Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA-GEYIC-TA 387 + + + ++W T +I E + + H L + +Q DA Y C T Sbjct: 210 SSVQEYVSVVSWEKDTVSIIPEHR-----FFITYH---GGLYISDVQKEDALSTYRCITK 261 Query: 388 SNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440 G+ QS + L G + W G+ V + C YP I W + Sbjct: 262 HKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK 321 Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498 DG+ LP+ + +I + L ++ D G Y C N G IL+ D Sbjct: 322 DGRPLPADSRWTKRI------TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373 Score = 44.3 bits (103), Expect = 5e-04 Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 50/328 (15%) Query: 208 VNVPPTIQARQNIVN----ATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ--IEQEEDDE 261 V + P +A I++ T + V L C++ G P P + WTKD E I D Sbjct: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399 Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---KPKITYVENQTA 318 + I ++ + L ++ V D Y C A N G ++L V +P++T + + Sbjct: 1400 RLIHTNGT--LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSAS 1457 Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378 +TLT + SI ++ + E+ D + + S R S L S++ Sbjct: 1458 -----SITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKD--VFISSSER--SFKLDSLKCG 1508 Query: 379 DAGEYICTASNTIGQDSQSMYLEVQ---YAPKLQGPVAVYT-------------WEGNQV 422 + A N++G S +E + P ++T W Sbjct: 1509 TWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGC 1568 Query: 423 NITCEVFAY-PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481 IT V Y P T +W Q L +++ + + A++ E+ + N G Sbjct: 1569 PITAIVLEYRPKGTWAW----QGLRANSSGEVFLTELREATWYELRMRACNSAG------ 1618 Query: 482 VNRIGQESLEFILVQADTPSSPSIDQVE 509 G E+ +F + D + P I + Sbjct: 1619 ---CGNETAQFATLDYDGSTIPPIKSAQ 1643 Score = 34.3 bits (77), Expect = 0.50 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 8/103 (7%) Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRD--VILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190 +D + C+ V P + W D + + D ++ +N L +R +K D G Y C Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424 Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233 G + + ++V VPP Q R + +A+ S+TL Sbjct: 1425 A--TNTGGFDTIIVNLLVQVPPD-QPRLTVSKTSAS---SITL 1461 >gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo sapiens] Length = 1248 Score = 127 bits (319), Expect = 4e-29 Identities = 161/696 (23%), Positives = 269/696 (38%), Gaps = 94/696 (13%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I W P+G V + + TL + +D G Y+C+ GS A Sbjct: 269 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 321 Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170 V + + + P + GE A + C V P + W+ G V L KD ++ + Sbjct: 322 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 380 Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225 L + ++ +D +CE R +LA I +V +P I N Sbjct: 381 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 434 Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284 G + L+C A G P P++ W +DG + Q+E F + L I+ + ND Sbjct: 435 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 489 Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342 Y C+A N +LKV +IT T + +VT TC+AS DP PSITWR Sbjct: 490 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549 Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402 R++ E D + + L + S+ Y+D G Y C AS + L V Sbjct: 550 GDGRDL-QELGDSDKYFI-----EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 603 Query: 403 QYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDGQLLPSSNYSN 452 +P GPV ++ +QV ++ +A I F D ++ P YS Sbjct: 604 VGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSL 660 Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS 512 K+ +++ L+++P F TA+N+ G + TP + P Sbjct: 661 GKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP------EAAPEK 711 Query: 513 STAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 + V+ + E T V P ++Y+ +WR G W + + + Sbjct: 712 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPWQE--QIVSDP 766 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPKLEG--QMGED 614 + + Y +++ A+N +G G +++ + P + P+LEG + Sbjct: 767 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPELEGIEILNSS 822 Query: 615 GNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGSDHVMLKSLDW 666 +K + +R Y V Y S+ K + +P+ + V+L L Sbjct: 823 AVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRP 882 Query: 667 NAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702 + Y + V A N +G A+ F F T P +P + Sbjct: 883 YSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 915 Score = 108 bits (271), Expect = 2e-23 Identities = 127/542 (23%), Positives = 203/542 (37%), Gaps = 76/542 (14%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96 C+ +G + W + +G P ++ V+ S + TI N + A GIY+C Sbjct: 52 CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 109 Query: 97 VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149 + + G+ + +LM + AP P E EGE V+ C+ S P Sbjct: 110 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 163 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205 I+ + + +K+D R + N L + +D + Y C I K D++ Sbjct: 164 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 223 Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 V I P + + + A GQ + L C AEGFP PT+ W + + Sbjct: 224 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 280 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 ++ + + + L + KV + D+ EY C+AEN G ++ V A P + Sbjct: 281 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 339 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E L C+ G P P +TWR + I EE D ++ A L L ++Q +D Sbjct: 340 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELAKDQKYRIQRGA----LILSNVQPSD 393 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITCEVFAYPSATI 436 C A N G + Y+ V P L Y +G+ + C+ F P ++ Sbjct: 394 TMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSV 453 Query: 437 SW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 W +D + P +N L + ND G Y C A N Sbjct: 454 QWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYFCLAANDQNNV 501 Query: 489 SLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542 ++ L D P S + + T Q FD P L+ WR G Sbjct: 502 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQPSITWRGDGR 553 Query: 543 EV 544 ++ Sbjct: 554 DL 555 Score = 84.7 bits (208), Expect = 3e-16 Identities = 119/511 (23%), Positives = 202/511 (39%), Gaps = 52/511 (10%) Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190 +G A ++C + P++ W + +L+ D RF +N L IR ++ D G Y C Sbjct: 435 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 492 Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248 LA + N I + V Q Q + G VT C A P +P+++W Sbjct: 493 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549 Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 DG +++ D +KY D +L I +D +D+ Y C+A + ++ L V P Sbjct: 550 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607 Query: 309 KIT--YVENQTAMELEEQVTLTCEASGD---PIPSITWRTSTRNISSEEKTLDGHMVVRS 363 V + + + QV ++ + D PI + ++ E+ + + + Sbjct: 608 GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK----WYSLGKV 663 Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGN 420 +S TLK Y + TA N G S E P+ + PV V EGN Sbjct: 664 PGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV-KGEGN 721 Query: 421 QVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470 + IT + + + W G P +I + P +L V+ S Sbjct: 722 ETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLVVSNTS 774 Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDEPEATG 526 AVN G+ + + D P + P ++ +E +S+A + P Sbjct: 775 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 834 Query: 527 GVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAVRLAAL 579 V + Y + G + HSK + K+ A+ ++ + GL+P ++Y + + A Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHLEVQAF 893 Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610 NG+G G S + + V G P A LE Q Sbjct: 894 NGRGSGPASEFTFSTPEGVPGHPEALHLECQ 924 Score = 60.1 bits (144), Expect = 9e-09 Identities = 95/385 (24%), Positives = 142/385 (36%), Gaps = 56/385 (14%) Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285 ++L C+A G PE WT+DG + +E+ ++ S S TI + N + Y Sbjct: 48 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 107 Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340 C A NK G I L PK E +E+E E V L C S +P+ Sbjct: 108 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 166 Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA----SNTIGQDS- 395 + +I +E+ G A V L S ++D YIC A + TI Q Sbjct: 167 MNSKILHIKQDERVTMGQNGNLYFANV----LTSDNHSD---YICHAHFPGTRTIIQKEP 219 Query: 396 -----QSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446 ++ + P+L P + +G + + C +P+ TI W R +P Sbjct: 220 IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMP 279 Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA-----DTP 500 + + T L++ E D G Y C A N +G ++ V+A P Sbjct: 280 ADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKP 334 Query: 501 SSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 S E QVQ +PE T WR G V D K G Sbjct: 335 QSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKYRIQRG 382 Query: 560 IVTIVGLKPETTYAVRLAALNGKGL 584 + + ++P T + A N GL Sbjct: 383 ALILSNVQPSDTMVTQCEARNRHGL 407 Score = 39.7 bits (91), Expect = 0.012 Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%) Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468 Q P + + + +++ CE P W RDG + +Y +P + +T Sbjct: 35 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 94 Query: 469 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 510 ++ N G Y C A N++G S E L+ P P + V+P Sbjct: 95 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 140 Score = 32.0 bits (71), Expect = 2.5 Identities = 46/195 (23%), Positives = 74/195 (37%), Gaps = 28/195 (14%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS-HARVSSLTLKSIQYTD-- 379 + ++L CEASG P W + +E+ G V +S H+ ++T + + Sbjct: 46 DDISLKCEASGKPEVQFRWTRDGVHFKPKEEL--GVTVYQSPHSGSFTITGNNSNFAQRF 103 Query: 380 AGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATI 436 G Y C ASN +G S + L + APK V EG V + C Sbjct: 104 QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCN--------- 154 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILV 495 P + ++IY ++ L + D G N N N + ++ + Sbjct: 155 ---------PPPSAEPLRIY-WMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 204 Query: 496 QADTPSSPSIDQVEP 510 A P + +I Q EP Sbjct: 205 HAHFPGTRTIIQKEP 219 >gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo sapiens] Length = 1253 Score = 127 bits (319), Expect = 4e-29 Identities = 161/696 (23%), Positives = 269/696 (38%), Gaps = 94/696 (13%) Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111 I W P+G V + + TL + +D G Y+C+ GS A Sbjct: 274 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 326 Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170 V + + + P + GE A + C V P + W+ G V L KD ++ + Sbjct: 327 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 385 Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225 L + ++ +D +CE R +LA I +V +P I N Sbjct: 386 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 439 Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284 G + L+C A G P P++ W +DG + Q+E F + L I+ + ND Sbjct: 440 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 494 Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342 Y C+A N +LKV +IT T + +VT TC+AS DP PSITWR Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554 Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402 R++ E D + + L + S+ Y+D G Y C AS + L V Sbjct: 555 GDGRDL-QELGDSDKYFI-----EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608 Query: 403 QYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDGQLLPSSNYSN 452 +P GPV ++ +QV ++ +A I F D ++ P YS Sbjct: 609 VGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSL 665 Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS 512 K+ +++ L+++P F TA+N+ G + TP + P Sbjct: 666 GKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP------EAAPEK 716 Query: 513 STAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 + V+ + E T V P ++Y+ +WR G W + + + Sbjct: 717 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPWQE--QIVSDP 771 Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPKLEG--QMGED 614 + + Y +++ A+N +G G +++ + P + P+LEG + Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPELEGIEILNSS 827 Query: 615 GNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGSDHVMLKSLDW 666 +K + +R Y V Y S+ K + +P+ + V+L L Sbjct: 828 AVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRP 887 Query: 667 NAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702 + Y + V A N +G A+ F F T P +P + Sbjct: 888 YSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 920 Score = 108 bits (271), Expect = 2e-23 Identities = 127/542 (23%), Positives = 203/542 (37%), Gaps = 76/542 (14%) Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96 C+ +G + W + +G P ++ V+ S + TI N + A GIY+C Sbjct: 57 CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114 Query: 97 VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149 + + G+ + +LM + AP P E EGE V+ C+ S P Sbjct: 115 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 168 Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205 I+ + + +K+D R + N L + +D + Y C I K D++ Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 228 Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259 V I P + + + A GQ + L C AEGFP PT+ W + + Sbjct: 229 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 285 Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319 ++ + + + L + KV + D+ EY C+AEN G ++ V A P + Sbjct: 286 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 344 Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379 E L C+ G P P +TWR + I EE D ++ A L L ++Q +D Sbjct: 345 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELAKDQKYRIQRGA----LILSNVQPSD 398 Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITCEVFAYPSATI 436 C A N G + Y+ V P L Y +G+ + C+ F P ++ Sbjct: 399 TMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSV 458 Query: 437 SW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488 W +D + P +N L + ND G Y C A N Sbjct: 459 QWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYFCLAANDQNNV 506 Query: 489 SLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542 ++ L D P S + + T Q FD P L+ WR G Sbjct: 507 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQPSITWRGDGR 558 Query: 543 EV 544 ++ Sbjct: 559 DL 560 Score = 84.7 bits (208), Expect = 3e-16 Identities = 119/511 (23%), Positives = 202/511 (39%), Gaps = 52/511 (10%) Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190 +G A ++C + P++ W + +L+ D RF +N L IR ++ D G Y C Sbjct: 440 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 497 Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248 LA + N I + V Q Q + G VT C A P +P+++W Sbjct: 498 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554 Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308 DG +++ D +KY D +L I +D +D+ Y C+A + ++ L V P Sbjct: 555 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612 Query: 309 KIT--YVENQTAMELEEQVTLTCEASGD---PIPSITWRTSTRNISSEEKTLDGHMVVRS 363 V + + + QV ++ + D PI + ++ E+ + + + Sbjct: 613 GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK----WYSLGKV 668 Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGN 420 +S TLK Y + TA N G S E P+ + PV V EGN Sbjct: 669 PGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV-KGEGN 726 Query: 421 QVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470 + IT + + + W G P +I + P +L V+ S Sbjct: 727 ETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLVVSNTS 779 Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDEPEATG 526 AVN G+ + + D P + P ++ +E +S+A + P Sbjct: 780 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 839 Query: 527 GVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAVRLAAL 579 V + Y + G + HSK + K+ A+ ++ + GL+P ++Y + + A Sbjct: 840 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHLEVQAF 898 Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610 NG+G G S + + V G P A LE Q Sbjct: 899 NGRGSGPASEFTFSTPEGVPGHPEALHLECQ 929 Score = 60.1 bits (144), Expect = 9e-09 Identities = 95/385 (24%), Positives = 142/385 (36%), Gaps = 56/385 (14%) Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285 ++L C+A G PE WT+DG + +E+ ++ S S TI + N + Y Sbjct: 53 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 112 Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340 C A NK G I L PK E +E+E E V L C S +P+ Sbjct: 113 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 171 Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA----SNTIGQDS- 395 + +I +E+ G A V L S ++D YIC A + TI Q Sbjct: 172 MNSKILHIKQDERVTMGQNGNLYFANV----LTSDNHSD---YICHAHFPGTRTIIQKEP 224 Query: 396 -----QSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446 ++ + P+L P + +G + + C +P+ TI W R +P Sbjct: 225 IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMP 284 Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA-----DTP 500 + + T L++ E D G Y C A N +G ++ V+A P Sbjct: 285 ADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKP 339 Query: 501 SSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559 S E QVQ +PE T WR G V D K G Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKYRIQRG 387 Query: 560 IVTIVGLKPETTYAVRLAALNGKGL 584 + + ++P T + A N GL Sbjct: 388 ALILSNVQPSDTMVTQCEARNRHGL 412 Score = 39.7 bits (91), Expect = 0.012 Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%) Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468 Q P + + + +++ CE P W RDG + +Y +P + +T Sbjct: 40 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99 Query: 469 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 510 ++ N G Y C A N++G S E L+ P P + V+P Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 145 Score = 32.0 bits (71), Expect = 2.5 Identities = 46/195 (23%), Positives = 74/195 (37%), Gaps = 28/195 (14%) Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS-HARVSSLTLKSIQYTD-- 379 + ++L CEASG P W + +E+ G V +S H+ ++T + + Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEEL--GVTVYQSPHSGSFTITGNNSNFAQRF 108 Query: 380 AGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATI 436 G Y C ASN +G S + L + APK V EG V + C Sbjct: 109 QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCN--------- 159 Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILV 495 P + ++IY ++ L + D G N N N + ++ + Sbjct: 160 ---------PPPSAEPLRIY-WMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209 Query: 496 QADTPSSPSIDQVEP 510 A P + +I Q EP Sbjct: 210 HAHFPGTRTIIQKEP 224 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.130 0.379 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,222,499 Number of Sequences: 37866 Number of extensions: 1634272 Number of successful extensions: 13290 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 282 Number of HSP's successfully gapped in prelim test: 295 Number of HSP's that attempted gapping in prelim test: 4901 Number of HSP's gapped (non-prelim): 3581 length of query: 848 length of database: 18,247,518 effective HSP length: 111 effective length of query: 737 effective length of database: 14,044,392 effective search space: 10350716904 effective search space used: 10350716904 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.