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Search of human proteins with 94420689
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
(848 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi... 1705 0.0
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap... 1697 0.0
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap... 1391 0.0
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 708 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 167 3e-41
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 162 1e-39
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 162 1e-39
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 155 2e-37
gi|19743806 roundabout 1 isoform b [Homo sapiens] 154 3e-37
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 154 3e-37
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 154 3e-37
gi|4506569 roundabout 1 isoform a [Homo sapiens] 154 3e-37
gi|224994173 roundabout 1 isoform d [Homo sapiens] 150 4e-36
gi|224994171 roundabout 1 isoform c [Homo sapiens] 150 4e-36
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 150 4e-36
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 150 4e-36
gi|110349719 titin isoform N2-A [Homo sapiens] 145 2e-34
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 145 2e-34
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 143 6e-34
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 142 2e-33
gi|157311649 neogenin homolog 1 [Homo sapiens] 141 3e-33
gi|109150416 peroxidasin [Homo sapiens] 140 6e-33
gi|222352127 sidekick 2 [Homo sapiens] 139 1e-32
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 139 1e-32
gi|142976733 surface glycoprotein, Ig superfamily member [Homo s... 137 3e-32
gi|119220552 sidekick 1 [Homo sapiens] 137 5e-32
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 130 7e-30
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 130 7e-30
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 127 4e-29
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 127 4e-29
>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
sapiens]
Length = 848
Score = 1705 bits (4416), Expect = 0.0
Identities = 848/848 (100%), Positives = 848/848 (100%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN
Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600
GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600
Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM 660
EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM
Sbjct: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVM 660
Query: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV 720
LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV
Sbjct: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIV 720
Query: 721 IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE 780
IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE
Sbjct: 721 IFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE 780
Query: 781 VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ 840
VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ
Sbjct: 781 VRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQ 840
Query: 841 TKENESKA 848
TKENESKA
Sbjct: 841 TKENESKA 848
>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
sapiens]
Length = 858
Score = 1697 bits (4395), Expect = 0.0
Identities = 848/858 (98%), Positives = 848/858 (98%), Gaps = 10/858 (1%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK------- 353
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPE 360
Query: 354 ---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 410
TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG
Sbjct: 361 KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG 420
Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS
Sbjct: 421 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 480
Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI
Sbjct: 481 ENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 540
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA
Sbjct: 541 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 600
Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 650
SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI
Sbjct: 601 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI 660
Query: 651 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 710
RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS
Sbjct: 661 RLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLS 720
Query: 711 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 770
TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS
Sbjct: 721 TGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFS 780
Query: 771 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 830
KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE
Sbjct: 781 KDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAE 840
Query: 831 VKTVPNDATQTKENESKA 848
VKTVPNDATQTKENESKA
Sbjct: 841 VKTVPNDATQTKENESKA 858
>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
sapiens]
Length = 761
Score = 1391 bits (3600), Expect = 0.0
Identities = 707/762 (92%), Positives = 710/762 (93%), Gaps = 37/762 (4%)
Query: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE
Sbjct: 1 MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGE 60
Query: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF
Sbjct: 61 KLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMF 120
Query: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK
Sbjct: 121 KNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIK 180
Query: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF
Sbjct: 181 KTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGF 240
Query: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI
Sbjct: 241 PEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV
Sbjct: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMV 360
Query: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN
Sbjct: 361 VRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT
Sbjct: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
Query: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV
Sbjct: 481 AVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV-- 598
GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV
Sbjct: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVHS 600
Query: 599 ---------------------------------QGEPSAPKLEGQMGEDGNSIKVNLIKQ 625
+GEPSAPKLEGQMGEDGNSIKVNLIKQ
Sbjct: 601 PPPPASASSSTPVPLSPPDTTWPLPALATTEPAKGEPSAPKLEGQMGEDGNSIKVNLIKQ 660
Query: 626 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA
Sbjct: 661 DDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 720
Query: 686 AHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 727
AHFVFRTSAQPTAIPA S T V +L LLL+
Sbjct: 721 AHFVFRTSAQPTAIPATLGGNSASYT--FVSLLFSAVTLLLL 760
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 708 bits (1828), Expect = 0.0
Identities = 383/855 (44%), Positives = 538/855 (62%), Gaps = 33/855 (3%)
Query: 7 LIWTLFFLGTAVS-----LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEK 61
L+ + + LG VS LQV I S+ E+SVGESKFF C G+ + I W++P GEK
Sbjct: 3 LLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPES--IDWYNPQGEK 60
Query: 62 LTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFK 121
+ Q+ VV + S LTIYNANI+DAGIY+C T G EATV ++I+QKL F+
Sbjct: 61 IISTQR--VVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFR 118
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
+PQEF++GEDA +VC V SS P + W + +V D RF +L+NN LQI I K
Sbjct: 119 EVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK 178
Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
+DEG YRCEGR+ ARGEI+F+DI VIVNVPP I Q NATA G+ +T C A G P
Sbjct: 179 SDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSP 238
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
EP +SW ++G+ I E++EKYI +++LT++ + +D Y+C A NKAGE +
Sbjct: 239 EPAISWFRNGKLI---EENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAF 295
Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE--KTLDGHM 359
L+VF +P I ++N+T E QVTL C+A G+PIP ITW+ + + E K+LDG +
Sbjct: 296 LQVFVQPHIIQLKNETTYE-NGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 354
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWE 418
V+ SSL +K ++ +D+G Y C A++ IG +SMYL+++YAPK + Y+WE
Sbjct: 355 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWE 414
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
GN +NI+C+V + P A+I W RD +LP+ N +N+K Y+T LE+ P S+NDFG YN
Sbjct: 415 GNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYN 474
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
CTA N IG E+IL AD PSSP + +E +TA+V F++P++ GGVPI Y+ +
Sbjct: 475 CTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDV 534
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+ V E+W + ++ +V + L+P TTY +R+AA+NGKG G+ S F+T P
Sbjct: 535 KEVASEIWKI----VRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLP 590
Query: 598 VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--WKPEIRLPSG 655
V+ EPS P + GQ G S K+++ KQDDGG+PI Y+V+YR+ E W E ++
Sbjct: 591 VR-EPSPPSIHGQ-PSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWL-EKKVQGN 647
Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 715
DH++L+ L W YEV + A N+ G S+ + F +P I + +GL GA++
Sbjct: 648 KDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNII--KDTLFNGLGLGAVI 705
Query: 716 GILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCG-KAGPGAKGKDMEEGKAAFSKDES 774
G+ + +L+LVV D++C+F+ +CGL MCI +CG K+G K K++EEGKAA+ KD S
Sbjct: 706 GLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGS 765
Query: 775 KEPIVEVRTEEERTPNH-DGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKT 833
KEPIVE+RTE+ER NH DG EPNETTPLTEPEK P+ K E + P E+K
Sbjct: 766 KEPIVEMRTEDERVTNHEDGSPVNEPNETTPLTEPEKLPL--KEEDGKEALNPETIEIK- 822
Query: 834 VPNDATQTKENESKA 848
V ND Q+KE++SKA
Sbjct: 823 VSNDIIQSKEDDSKA 837
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 167 bits (424), Expect = 3e-41
Identities = 127/428 (29%), Positives = 189/428 (44%), Gaps = 25/428 (5%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGED 134
++ S L I +A + D G Y C T G +E VN+ + + + T EG
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNL 2213
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS-NNYLQIRGIKKTDEGTYRCEGRI 193
++C+ PP +IWK KG V+ R +LS LQI +K+D Y C
Sbjct: 2214 ISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASN 2273
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
+A ++QV + P + + G+S++L C+ +G P PT++W KDG
Sbjct: 2274 VAGTAKKEYNLQVYIR-PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP 2332
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--- 310
+ + + E D+ L +K + +D Y+C+A N AG D L V A P I
Sbjct: 2333 LIKAKGVE---ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN 2389
Query: 311 -TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
EN + +E + V+LTCEASG P+PSITW +S L + + S R+
Sbjct: 2390 HRSPENISVVE-KNSVSLTCEASGIPLPSITWFKDGWPVS-----LSNSVRILSGGRM-- 2441
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITC 426
L L DAG+Y C N G++ + L V P + G V E V +TC
Sbjct: 2442 LRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
EV P I+W +DGQ L +I +L++T G Y C A + G
Sbjct: 2502 EVTGNPVPEITWHKDGQPLQEDEAHHI----ISGGRFLQITNVQVPHTGRYTCLASSPAG 2557
Query: 487 QESLEFIL 494
+S F L
Sbjct: 2558 HKSRSFSL 2565
Score = 160 bits (404), Expect = 6e-39
Identities = 121/473 (25%), Positives = 197/473 (41%), Gaps = 61/473 (12%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-V 110
I+WF N RI L + ++DAG Y CVV G E + +
Sbjct: 2418 ITWFKDGWPVSLSNSVRIL-----SGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGL 2472
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+V + ++ +N + +E + + C+V + P I W HK + + + I+
Sbjct: 2473 SVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW-HKDGQPLQEDEAHHIISG 2531
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV--PPTIQ---ARQNIVNATA 225
+LQI ++ G Y C LA K +NV PTI + N + T
Sbjct: 2532 GRFLQITNVQVPHTGRYTC----LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
L +LVC+A +P T++W KDG +E + L I +++ Y
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIR---ILPGGRTLQILNAQEDNAGRY 2644
Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIP 337
C+A N+AGE +KV+ P I + + +++ +TL CEA P
Sbjct: 2645 SCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
S++W + + S D H+ + ++ +L +K Q +D G Y C ASN G+D
Sbjct: 2705 SLSWYKDGQPLKS-----DDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAGEDELD 2757
Query: 398 MYLEVQYAPKLQGPVAVYTWE------------------GNQVNITCEVFAYPSATISWF 439
+ +Q P Q WE N +++ CE A P T++W+
Sbjct: 2758 FDVNIQVPPSFQ-----KLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWY 2812
Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+DG L SS+ K+ P L++ D G Y C AVN G++SL++
Sbjct: 2813 KDGHPLTSSD----KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQY 2861
Score = 158 bits (399), Expect = 2e-38
Identities = 114/420 (27%), Positives = 183/420 (43%), Gaps = 33/420 (7%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L + +A I D G Y CV G E + ++++++ + ++C
Sbjct: 2068 LALTSAQISDTGRYTCVAVNAAG-EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQ 2126
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ PPT+ W G +LKK I + + L+I + D G Y CE +A G+
Sbjct: 2127 SDAIPPPTLTWLKDGHP-LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA-GKTE 2184
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
K+ V + VPP I + T G ++L+C++ G P P + W K G + +
Sbjct: 2185 -KNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMG 2243
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV---ENQT 317
I S QL I +K+D A Y C+A N AG +L+V+ +P IT +
Sbjct: 2244 RVRILS-GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI 2302
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-----RVSSLTL 372
+ + ++L CE G P P++TW DGH ++++ L L
Sbjct: 2303 IVTRGKSISLECEVQGIPPPTVTWMK------------DGHPLIKAKGVEILDEGHILQL 2350
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEV 428
K+I +D G Y+C A N G + L V P + G P + E N V++TCE
Sbjct: 2351 KNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEA 2410
Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
P +I+WF+DG P S ++++I + L + + D G Y C N G+E
Sbjct: 2411 SGIPLPSITWFKDG--WPVSLSNSVRILS--GGRMLRLMQTTMEDAGQYTCVVRNAAGEE 2466
Score = 155 bits (393), Expect = 1e-37
Identities = 141/515 (27%), Positives = 215/515 (41%), Gaps = 47/515 (9%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A +DAG Y CV G+ A +K+ ++ +P +E+ D I
Sbjct: 4040 SGGLQISRAVREDAGTYMCVAQNPAGT---ALGKIKLNVQVPPVISPHLKEYVIAVDKPI 4096
Query: 138 V--CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
C+ PP I W GR ++ + +R VLS+ LQI ++ D G Y C +A
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIV--ESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVA 4154
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
++ V+VPP I++ + + T N L C A+G P P ++W KD +
Sbjct: 4155 GSSST--STKLTVHVPPRIRSTEG--HYTVNENSQAILPCVADGIPTPAINWKKDNVLLA 4210
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
KY ++ +L ++ V D Y C+A N AGE T+ L V P T +
Sbjct: 4211 NLLG--KYT-AEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPG 4267
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
++ EQ+ L+C+A+G P+P +TW + I + +++GH S L ++ +
Sbjct: 4268 DVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH---------SELVIERV 4318
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPS 433
D+G Y+CTA N++G ++ V+ P +G E G + CEV P+
Sbjct: 4319 SKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPT 4378
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
TI W R G + S+ ++ N A Y V D+ G+Y C A N G
Sbjct: 4379 PTIQWNRKGVDIEISHRIR-QLGNGSLAIYGTVNEDA----GDYTCVATNEAGVVERSMS 4433
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW----HS-K 548
L T SP I +EP + GG IL +A W HS
Sbjct: 4434 L----TLQSPPIITLEPVETVIN--------AGGKIILNCQATGEPQPTITWSRQGHSIS 4481
Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
W D + I + E T A N G
Sbjct: 4482 WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 154 bits (388), Expect = 4e-37
Identities = 134/494 (27%), Positives = 214/494 (43%), Gaps = 54/494 (10%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P + +I V + C+ A +SW+ +G+ L + +++ N TL I
Sbjct: 2681 PKEVKIKVNNTLTLECE-AYAIPSASLSWYK-DGQPLK-SDDHVNIAAN---GHTLQIKE 2734
Query: 86 ANIDDAGIYKCV---VTGEDGSESEATVNVKI---FQKLM-FKNAPTPQEFREGEDAVI- 137
A I D G Y CV + GED E + VN+++ FQKL N E +D +I
Sbjct: 2735 AQISDTGRYTCVASNIAGED--ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIIN 2792
Query: 138 -----VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR 192
C+ ++ PPT+ W G + D I+ LQI K D G Y C
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHP-LTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA- 2850
Query: 193 ILARGEINFK-DIQVIVNVPPTIQARQNIV--NATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ GE + + D++V+V PP I+ + + T + +S + C + G P P SW K
Sbjct: 2851 VNEAGEDSLQYDVRVLV--PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
DG+ + + D+ + F + L I D Y+C+AEN AG +L V P
Sbjct: 2909 DGQPLLE---DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS 2965
Query: 310 ITYVENQT-AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTL---DGHMVVRSHA 365
+ +++ + + ++LTCE SG P P ++W + + I TL G + A
Sbjct: 2966 VIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRA 3025
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-----QGPVAVYTWEGN 420
+VS D GEY C A N G+ + L V P + + V EG
Sbjct: 3026 KVS----------DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 421 QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
V++ CE A P I+W+++G+++ S + I L + +D G Y C
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEI----LADGQMLHIKKAEVSDTGQYVCR 3131
Query: 481 AVNRIGQESLEFIL 494
A+N G++ F L
Sbjct: 3132 AINVAGRDDKNFHL 3145
Score = 153 bits (387), Expect = 6e-37
Identities = 132/477 (27%), Positives = 206/477 (43%), Gaps = 34/477 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P ++ + S C+ AG+ ++W + RI L I +
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPI-LTWLKDGVPVKANDNIRIEA-----GGKKLEIMS 1701
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV--CDVVS 143
A D G Y CV T G E E V + + F + ++ C V
Sbjct: 1702 AQEIDRGQYICVATSVAG-EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
S PPTI+W G+ +I ++D I+L+ L I + ++ G YRC A + K+
Sbjct: 1761 SPPPTIMWLKDGQ-LIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD--HKKE 1817
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+V V+VPPTI++ + + V L C A G P P+++W KD + + + + K
Sbjct: 1818 FEVTVHVPPTIKS-SGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK- 1875
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT---YVENQTAME 320
L I K D Y C+A N AGE I L V P + + N+T +
Sbjct: 1876 -IQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVL- 1933
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
+ V L C+A+G+P+P ITW R +S M + ++ + ++S Q +DA
Sbjct: 1934 VSNPVQLECKAAGNPVPVITWYKDNRLLSGSTS-----MTFLNRGQI--IDIESAQISDA 1986
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437
G Y C A N+ G L+V AP + G VAV N V + CE P+ +++
Sbjct: 1987 GIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVV--NNPVRLECEARGIPAPSLT 2044
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
W +DG P S++SN + L +T +D G Y C AVN G++ + L
Sbjct: 2045 WLKDGS--PVSSFSN-GLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDL 2098
Score = 152 bits (385), Expect = 1e-36
Identities = 120/476 (25%), Positives = 190/476 (39%), Gaps = 30/476 (6%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P ++ VG+ C G I+W L + +S + TL+I
Sbjct: 1177 PKHLKVQVGQRVDIPCNAQGTPLPV-ITWSKGGSTMLVDGEHHVS-----NPDGTLSIDQ 1230
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE---GEDAVIVCDV 141
A DAGIY CV T G+ E+E T++V+ + P F+E + C
Sbjct: 1231 ATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPA 1290
Query: 142 VSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF 201
+ PTI W H GR++ ++ I+ L I + D G Y C +
Sbjct: 1291 KGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA--VNEAGTTE 1348
Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+ + V+VPP I+ ++ + N + L Q L C+ EG P P + W KD Q+ + +
Sbjct: 1349 RKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQ 1408
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAM 319
++ L + + D Y C A N AG ++ V P I T N+ ++
Sbjct: 1409 TV---NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
L V L C+ G P P I W + G V R L LK+ + D
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHW------FKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFAYPSATI 436
G Y CT SN G+ ++ + L + P ++G + + + + CE P I
Sbjct: 1520 KGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAI 1579
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+W++DGQ + SS+ + +Y YL + +D Y C N G F
Sbjct: 1580 TWYKDGQPIMSSSQA---LY-IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSF 1631
Score = 150 bits (380), Expect = 4e-36
Identities = 125/475 (26%), Positives = 202/475 (42%), Gaps = 49/475 (10%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+WF +G L N+ I ++ TL I NA D+AG Y CV T E G E
Sbjct: 2607 ITWFK-DGTPLESNRN-IRIL---PGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYE 2660
Query: 112 VKIFQKLMFKN--------APTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKD 163
VK++ + +P + + + C+ + ++ W G+ LK D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQP--LKSD 2718
Query: 164 VRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN 222
+ +N + LQI+ + +D G Y C +A GE D V + VPP+ Q I N
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIA-GEDEL-DFDVNIQVPPSFQKLWEIGN 2776
Query: 223 A--TANLGQS--------VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQL 272
T G++ ++L C+ P PT++W KDG + + K + L
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSD---KVLILPGGRVL 2833
Query: 273 TIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL----EEQVTLT 328
I + D Y C+A N+AGE ++V P I + E+ + +
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIE 2893
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
C +SG P P +W+ + + D H S+ R+ L + + Q TD G Y+C A
Sbjct: 2894 CLSSGSPAPRNSWQKDGQPLLE-----DDHHKFLSNGRI--LQILNTQITDIGRYVCVAE 2946
Query: 389 NTIGQDSQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
NT G + L V P + GP + + N +++TCEV +P +SW ++ Q +
Sbjct: 2947 NTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
+ + I P L++ +D G Y C A+N+ G+ +F L PS
Sbjct: 3007 LNTNTLI----VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS 3057
Score = 150 bits (378), Expect = 6e-36
Identities = 133/501 (26%), Positives = 206/501 (41%), Gaps = 52/501 (10%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+W+ NG +T + + ++ + L I A + D G Y C G +
Sbjct: 3091 ITWYK-NGRMITESTH-VEILAD---GQMLHIKKAEVSDTGQYVCRAINVAGRDD----- 3140
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIV----------CDVVSSLPPTIIW--KHKGRDVI 159
K N P E VIV CD PPTI W HK +
Sbjct: 3141 -----KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENS 3195
Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQN 219
+VR I+ + LQI + +D G Y C + G+ K + + VPP++ +
Sbjct: 3196 DSLEVR-ILSGGSKLQIARSQHSDSGNYTCIASNM-EGKAQ-KYYFLSIQVPPSVAGAEI 3252
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
+ + LG++V LVC+A G P P + W KDG+ I E E+ S + S L I
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGE-TERIRVSANGSTLNIYGALT 3311
Query: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKI--TYVENQTAMEL-EEQVTLTCEASGDPI 336
+D +Y C+A N AGE+D +L V+ P I E + M L + + + C A+G P
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 337 PSITWRTS--TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
P I W + +SS + L V+R + Q +D Y C ASN G D
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIR---------IVRAQVSDVAVYTCVASNRAGVD 3422
Query: 395 SQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
++ L+V P + G + +G+ ++ C P+ +++W RDGQ L +
Sbjct: 3423 NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHL 3482
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
+ + L++ D G Y C A N G+ S FIL + P ++ E
Sbjct: 3483 TVSTH----GMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEI 3538
Query: 512 SSTAQVQFDEPEATGGVPILK 532
S + G+P K
Sbjct: 3539 SVIVNNPLELTCIASGIPAPK 3559
Score = 148 bits (373), Expect = 2e-35
Identities = 125/483 (25%), Positives = 201/483 (41%), Gaps = 39/483 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G+S C+V G ++W + I D L + N
Sbjct: 2299 PTEIIVTRGKSISLECEVQG-IPPPTVTWMKDGHPLIKAKGVEIL-----DEGHILQLKN 2352
Query: 86 ANIDDAGIYKCVVTGEDG-SESEATVNVKIFQKLMFKN-APTPQEFREGEDAVIVCDVVS 143
++ D G Y CV G ++ + ++V ++ + +P E + C+
Sbjct: 2353 IHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASG 2412
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
P+I W G V L VR I+ L++ D G Y C R A E
Sbjct: 2413 IPLPSITWFKDGWPVSLSNSVR-ILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFG 2471
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+ V+V PP I + + QSVTL C+ G P P ++W KDG+ + +ED+ +
Sbjct: 2472 LSVLV--PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPL--QEDEAHH 2527
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--- 320
I S L I V Y C+A + AG + + L VF P I V + E
Sbjct: 2528 IIS-GGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 321 --LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
L +L CEA P +ITW + L+ + +R +L + + Q
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITW-------FKDGTPLESNRNIRILPGGRTLQILNAQED 2639
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQ---------GPVAVYTWEGNQVNITCEVF 429
+AG Y C A+N G+ + ++V P + P V N + + CE +
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
A PSA++SW++DGQ L S ++ NI + L++ +D G Y C A N G++
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNI----AANGHTLQIKEAQISDTGRYTCVASNIAGEDE 2755
Query: 490 LEF 492
L+F
Sbjct: 2756 LDF 2758
Score = 144 bits (364), Expect = 3e-34
Identities = 118/473 (24%), Positives = 202/473 (42%), Gaps = 41/473 (8%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+ AG+ I+W+ N +L ++ + + + I +A I DAGIYKCV
Sbjct: 1942 CKAAGNPVPV-ITWYKDN--RLLSGSTSMTFL---NRGQIIDIESAQISDAGIYKCVAIN 1995
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI------VCDVVSSLPPTIIWKHK 154
G+ ++F L AP+ V+ C+ P++ W
Sbjct: 1996 SAGA-------TELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKD 2048
Query: 155 GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTI 214
G V + ++ L + + +D G Y C + A GE +DI + V VPP I
Sbjct: 2049 GSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQ-RDIDLRVYVPPNI 2106
Query: 215 QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTI 274
+ N + + Q+V L+C ++ P PT++W KDG + ++ S++ S L I
Sbjct: 2107 MGEEQ--NVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG---LSISENRSVLKI 2161
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ--VTLTCEAS 332
+ D Y C A N AG+ + ++ ++ P I + T + + E ++L CE+S
Sbjct: 2162 EDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESS 2221
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P++ W+ + ++ G + + S R L + + +DA Y C ASN G
Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSM---GRVRILSGGR--QLQISIAEKSDAALYSCVASNVAG 2276
Query: 393 QDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448
+ L+V P + P + G +++ CEV P T++W +DG P
Sbjct: 2277 TAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGH--PLI 2334
Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
++I + L++ +D G Y C AVN G ++ L PS
Sbjct: 2335 KAKGVEILD--EGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS 2385
Score = 144 bits (362), Expect = 4e-34
Identities = 103/414 (24%), Positives = 175/414 (42%), Gaps = 17/414 (4%)
Query: 75 DDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGED 134
+ +S L I + D G Y+C+ G+ A + + P GE
Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGT-GRAQTFFDVSEPPPVIQVPNNVTVTPGER 536
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
AV+ C ++S++ + W+ RDV L + R L+N L+++ +K D G Y C +
Sbjct: 537 AVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHC--MVS 594
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
+ G + + + V PP + N + G V+++C A G+P+P ++WT + I
Sbjct: 595 SEGGSSAASVFLTVQEPPKVTVMPK--NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI 652
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
+Y + D + L IK D Y C+A N AG L+ PK+ V+
Sbjct: 653 ---VGSHRYRMTSDGT-LFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQ 708
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
++ + L + + C+ SG P P + W + + + + L ++
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPL-------LGLLKIQE 761
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPS 433
Q DAG+Y C A N G+ + + L+V P +Q P V G+ V + C V YP
Sbjct: 762 TQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPE 821
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
TI W R + S ++ + L + +D G Y C A N+ G+
Sbjct: 822 PTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGK 875
Score = 142 bits (357), Expect = 2e-33
Identities = 122/454 (26%), Positives = 183/454 (40%), Gaps = 32/454 (7%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139
L I A ++D G Y C+ + G + E V V + + + P + C
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC 3643
Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
+ PP I W G + VR I+ YLQI D Y C +A G+
Sbjct: 3644 KSDAVPPPVITWLRNGERLQATPRVR-ILSGGRYLQINNADLGDTANYTCVASNIA-GKT 3701
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
++ + VNVPP I+ + L +S L C AEG P P ++W KDG +
Sbjct: 3702 T-REFILTVNVPPNIKGGPQ--SLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+ ++ L I+ D Y+C+A N AG I L+V P I +
Sbjct: 3759 RYSIL---ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV 3815
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ Q TL CEA+G P PSI WR ++ + ++ + + ++ S SL + S D
Sbjct: 3816 IVNVQTTLACEATGIPKPSINWR-KNGHLLNVDQNQNSYRLLSS----GSLVIISPSVDD 3870
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISW 438
Y CT +N G D +++ L VQ P + P + ITC P +I W
Sbjct: 3871 TATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHW 3930
Query: 439 FRDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
++G +LLP + Y S+ +E+ N G Y C A N G L
Sbjct: 3931 TKNGIRLLPRGDG-----YRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVH 3985
Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEP-----EATG 526
+ P ++P S V + P EATG
Sbjct: 3986 EPP------VIQPQPSELHVILNNPILLPCEATG 4013
Score = 140 bits (353), Expect = 5e-33
Identities = 115/412 (27%), Positives = 174/412 (42%), Gaps = 24/412 (5%)
Query: 81 LTIYNANIDDAGIYKCVVT---GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
L I A + + G+Y+C+ G+ E E TV+V K++ + V
Sbjct: 1790 LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPP----TIKSSGLSERVVVKYKPVA 1845
Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
+ + + +P P+I W + V + I S LQI D G Y C A
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA- 1904
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GE + IQ+ V+ PP+++ ++N T + V L C A G P P ++W KD +
Sbjct: 1905 GETQ-QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS- 1962
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
F + + I+ +D Y C+A N AG + L+V P I+ N
Sbjct: 1963 --GSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
A+ + V L CEA G P PS+TW +SS L V S R+ +LT S Q
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ----VLSGGRILALT--SAQ 2074
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSAT 435
+D G Y C A N G+ + + L V P + G V V + C+ A P T
Sbjct: 2075 ISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPT 2134
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
++W +DG L +I + + S L++ D G Y C A N G+
Sbjct: 2135 LTWLKDGHPLLKKPGLSI----SENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Score = 139 bits (350), Expect = 1e-32
Identities = 130/478 (27%), Positives = 197/478 (41%), Gaps = 41/478 (8%)
Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
+V S+ +++G+ C+ +G + WF + E L P+ I D L I
Sbjct: 706 VVQSELLVALGDITVMECKTSG-IPPPQVKWFKGDLE-LRPSTFLII----DPLLGLLKI 759
Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVS 143
DAG Y CV E G + + + + +F P G + + C V
Sbjct: 760 QETQDLDAGDYTCVAINEAG-RATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQG 818
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEIN 200
PTI W+ I + +S L I + +D+GTY CE A +
Sbjct: 819 YPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICE----AENQFG 874
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANL--GQSVTLVCDA-EGFPEPTMSWTKDGEQIEQE 257
+ V V + I + AN+ GQ +TL C G P P W K+ + Q
Sbjct: 875 KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQN 934
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
YI L I++V D EY C+A N AG + T + V P I + +
Sbjct: 935 P----YITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
+ VTL C+ASG+P PS+ W IS+ S SL + S
Sbjct: 991 STIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKF-------SAGADGSLYVVSPGG 1043
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---------PVAVYTWEGNQVNITCEV 428
++GEY+CTA+NT G + + L V P++ G PV + G +V + CEV
Sbjct: 1044 EESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV 1103
Query: 429 FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+ P I+W ++ QL+ S +S + PS S +++T +D G Y C A N G
Sbjct: 1104 KSLPPPIITWAKETQLI--SPFSPRHTF-LPSGS-MKITETRTSDSGMYLCVATNIAG 1157
Score = 139 bits (349), Expect = 1e-32
Identities = 119/457 (26%), Positives = 197/457 (43%), Gaps = 29/457 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I+W+ +G+ + + Q + + D L I A + D+ Y C V G+ +E + +
Sbjct: 1579 ITWYK-DGQPIMSSSQALYI----DKGQYLHIPRAQVSDSATYTCHVANVAGT-AEKSFH 1632
Query: 112 VKIFQKLMFK-NAPTP--QEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
V ++ M + N TP ++ + C + P + W G V ++R I
Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIR-IE 1691
Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
L+I ++ D G Y C +A GE K +V V VPP I+ +
Sbjct: 1692 AGGKKLEIMSAQEIDRGQYICVATSVA-GEKEIK-YEVDVLVPPAIEGGDETSYFIVMVN 1749
Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
+ L C G P PT+ W KDG+ I+ E D K + + +L I + ++ Y C+
Sbjct: 1750 NLLELDCHVTGSPPPTIMWLKDGQLID-ERDGFKILL--NGRKLVIAQAQVSNTGLYRCM 1806
Query: 289 AENKAGEQDATIHLKVFAKPKI-TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
A N AG+ + V P I + ++ + + V L C A+G P PSITW +
Sbjct: 1807 AANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQP 1866
Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK 407
++ T G++ ++S RV L + DAG Y C A+N G+ Q + L V P
Sbjct: 1867 VN----TAQGNLKIQSSGRV--LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPS 1920
Query: 408 LQGPVAVY---TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
L+ + N V + C+ P I+W++D +LL S +++ N +
Sbjct: 1921 LEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS--TSMTFLN--RGQII 1976
Query: 465 EVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
++ +D G Y C A+N G L + L PS
Sbjct: 1977 DIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPS 2013
Score = 138 bits (348), Expect = 2e-32
Identities = 115/435 (26%), Positives = 184/435 (42%), Gaps = 30/435 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEAT-VNVKIFQKLMFKNAPTPQEFREGEDAV 136
S ++ I D+G+Y CV T G+ ++A +NV + K+ + P + + G+
Sbjct: 1132 SGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI--QRGPKHLKVQVGQRVD 1189
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I C+ + P I W KG +L + + L I +D G Y C +A
Sbjct: 1190 IPCNAQGTPLPVITWS-KGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAG 1248
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATAN---LGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
+ +I + V PPT++ + N T Q + C A+G P+PT+ W +G +
Sbjct: 1249 TDET--EITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRE 1306
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
+ E + +D + L I V D EYIC+A N+AG + +LKV P I
Sbjct: 1307 LTGREPGISIL--EDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDK 1364
Query: 314 ENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI--SSEEKTLDGHMVVRSHARVSS 369
E T + L + L CE G P P I W + SS +T++ +++
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPE 1424
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITC 426
DAG Y C A N G + ++V P + G P V V + C
Sbjct: 1425 ---------DAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALEC 1475
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+V P I WF+DG+ L + N+++ + +L+ ND G Y CT N G
Sbjct: 1476 QVKGTPFPDIHWFKDGKPLFLGD-PNVELLDRGQVLHLKNA--RRNDKGRYQCTVSNAAG 1532
Query: 487 QESLEFILVQADTPS 501
+++ + L PS
Sbjct: 1533 KQAKDIKLTIYIPPS 1547
Score = 135 bits (340), Expect = 2e-31
Identities = 117/480 (24%), Positives = 195/480 (40%), Gaps = 28/480 (5%)
Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
F L V + P I + +S C +A I+W +G L N R S+
Sbjct: 3705 FILTVNVPPNIKGGPQSLVILLNKSTVLEC-IAEGVPTPRITW-RKDGAVLAGNHARYSI 3762
Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE 131
+ N L I +A++ D G Y C+ T G++ +++++ PT
Sbjct: 3763 LEN----GFLHIQSAHVTDTGRYLCMATNAAGTDRRR-IDLQVHVPPSIAPGPTNMTVIV 3817
Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCE 190
+ C+ P+I W+ G + + ++ + +LS+ L I D TY C
Sbjct: 3818 NVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECT 3877
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+ + + + + V VPP+I T + +T C A G P P++ WTK+
Sbjct: 3878 --VTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT--CTASGVPFPSIHWTKN 3933
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
G ++ D + + S + I N Y C+A N AG + L V P I
Sbjct: 3934 GIRLLPRGDGYRIL---SSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVI 3990
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
++ + L + L CEA+G P P ITW+ N+++ + H V+ S L
Sbjct: 3991 QPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGR---NHAVLPS----GGL 4043
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQ-VNITCEVF 429
+ DAG Y+C A N G + L VQ P + + Y ++ + ++CE
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEAD 4103
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P I+W +DG+ + S + S+ L++ D G+Y C A N G S
Sbjct: 4104 GLPPPDITWHKDGRAIVESIRQRVL-----SSGSLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Score = 128 bits (322), Expect = 2e-29
Identities = 120/513 (23%), Positives = 200/513 (38%), Gaps = 29/513 (5%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGED 134
+ + I A + D +Y CV + G +++ N+++F N+ +E +G
Sbjct: 3394 AGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH-YNLQVFAPPNMDNSMGTEEITVLKGSS 3452
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRI 193
+ C + P++ W G+ + L D V ++ LQ+ + D G Y C
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGL--DAHLTVSTHGMVLQLLKAETEDSGKYTCIASN 3510
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ 253
A GE++ K + V PP I + + + + L C A G P P M+W KDG
Sbjct: 3511 EA-GEVS-KHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRP 3568
Query: 254 IEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV 313
+ Q + + L I D Y C+A + AG+ D ++V P I
Sbjct: 3569 LPQTDQVQTL---GGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT 3625
Query: 314 ENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
+ + + QVTL C++ P P ITW + + + + VR + L
Sbjct: 3626 DEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPR-------VRILSGGRYLQ 3678
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA 430
+ + D Y C ASN G+ ++ L V P ++ GP ++ + C
Sbjct: 3679 INNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEG 3738
Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
P+ I+W +DG +L + N++ Y+ +L + D G Y C A N G +
Sbjct: 3739 VPTPRITWRKDGAVL-AGNHAR---YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRR 3794
Query: 491 EFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
I +Q P PSI P + T V A I K WR G + +
Sbjct: 3795 R-IDLQVHVP--PSI-APGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ 3850
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
++ G + I+ + T NG G
Sbjct: 3851 NSYRLLSSGSLVIISPSVDDTATYECTVTNGAG 3883
Score = 124 bits (312), Expect = 3e-28
Identities = 115/473 (24%), Positives = 186/473 (39%), Gaps = 32/473 (6%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
S +L I + D G Y CV + G+ ++ T +V + ++ EG
Sbjct: 941 SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIEGIPVT 999
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
+ C + P++IW KG ++I +F ++ L + + G Y C A
Sbjct: 1000 LPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA- 1057
Query: 197 GEINFKDIQVIVNVPPTIQARQN------IVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G K +Q+ V V P + Q V + G+ VTL C+ + P P ++W K+
Sbjct: 1058 GYAKRK-VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE 1116
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
+ I ++ S + I + +D Y+C+A N AG + L V PKI
Sbjct: 1117 TQLISPFSPRHTFL---PSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKI 1173
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
+++ ++V + C A G P+P ITW + +DG V + +L
Sbjct: 1174 QRGPKHLKVQVGQRVDIPCNAQGTPLPVITW-----SKGGSTMLVDGEHHVSNPD--GTL 1226
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW------EGNQVNI 424
++ +DAG Y C A+N G D + L VQ P ++ Y ++
Sbjct: 1227 SIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEF 1286
Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
C P TI W +G+ L + I I + L + + D G Y C AVN
Sbjct: 1287 PCPAKGTPKPTIKWLHNGREL-TGREPGISILE--DGTLLVIASVTPYDNGEYICVAVNE 1343
Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYS---STAQVQFDEPEATGGVPILKYK 534
G ++ L P +QV S + F E E T I+ YK
Sbjct: 1344 AGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK 1396
Score = 121 bits (303), Expect = 3e-27
Identities = 116/442 (26%), Positives = 178/442 (40%), Gaps = 40/442 (9%)
Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
DI+W + +QR+ SS +L I DAG Y C+ GS S +T
Sbjct: 4109 DITWHKDGRAIVESIRQRVL------SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST- 4161
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDV--RFI 167
+ + ++ E A++ C V +P P I WK +D +L ++ ++
Sbjct: 4162 KLTVHVPPRIRSTEGHYTVNENSQAILPC-VADGIPTPAINWK---KDNVLLANLLGKYT 4217
Query: 168 VLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANL 227
L + + D G Y C A GE + + + V+V PT + + N
Sbjct: 4218 AEPYGELILENVVLEDSGFYTCVAN-NAAGE-DTHTVSLTVHVLPTFTELPG--DVSLNK 4273
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G+ + L C A G P P ++WT + I D + S+L I++V K D Y+C
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDS-----VNGHSELVIERVSKEDSGTYVC 4328
Query: 288 IAENKAGEQDATIHLKVFAKP--KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
AEN G A + V P K Y N L L CE GDP P+I W
Sbjct: 4329 TAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIE-PLGGNAILNCEVKGDPTPTIQWNRKG 4387
Query: 346 RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405
+I + +R SL + DAG+Y C A+N G +SM L +Q
Sbjct: 4388 VDIEISHR-------IRQLGN-GSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP 4439
Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
P + PV G ++ + C+ P TI+W R G + + N+ N+ L
Sbjct: 4440 PIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS-----L 4494
Query: 465 EVTPDSENDFGNYNCTAVNRIG 486
+ + D + C A N +G
Sbjct: 4495 YIADAQKEDTSEFECVARNLMG 4516
Score = 120 bits (302), Expect = 4e-27
Identities = 114/466 (24%), Positives = 184/466 (39%), Gaps = 27/466 (5%)
Query: 25 VPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIY 84
VP+ ++ GE C + A D +++W + + RI + N +L +
Sbjct: 525 VPNNVTVTPGERAVLTCLIIS-AVDYNLTWQRNDRDVRLAEPARIRTLAN----LSLELK 579
Query: 85 NANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ +DAG Y C+V+ E GS S A+V + + + P Q F G + I+C
Sbjct: 580 SVKFNDAGEYHCMVSSEGGS-SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGY 638
Query: 145 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P I W D+ + R+ + S+ L I+ D G Y C A + +
Sbjct: 639 PKPKIAWTVN--DMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
+ I P + + ++ A LG + C G P P + W K ++ I
Sbjct: 697 RYI-EAPKLMVVQSELLVA---LGDITVMECKTSGIPPPQVKWFKGDLELRPSTF---LI 749
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
L I++ D +Y C+A N+AG I L V + P +ME+
Sbjct: 750 IDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSN 809
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
VTL C G P P+I WR N+ + + S R +L + ++ +D G YI
Sbjct: 810 VTLPCYVQGYPEPTIKWR-RLDNMPIFSRPFSVSSI--SQLRTGALFILNLWASDKGTYI 866
Query: 385 CTASNTIG--QDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFA-YPSATISWFR 440
C A N G Q ++ + AP + P EG Q+ + C + A P W +
Sbjct: 867 CEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK 926
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
+ +L + Y ++ S L + D G Y C A N G
Sbjct: 927 NSAMLLQNPYITVR-----SDGSLHIERVQLQDGGEYTCVASNVAG 967
Score = 111 bits (277), Expect = 3e-24
Identities = 100/372 (26%), Positives = 159/372 (42%), Gaps = 35/372 (9%)
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I C V S LP T+ + G V L D ++ L I + +DEG Y C + +
Sbjct: 449 IPCSVDSLLPFTLSFVRNG--VTLGVDQYLKESASVNLDIAKVTLSDEGFYECIA-VSSA 505
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
G + + PP IQ N+ T G+ L C + ++W ++ +
Sbjct: 506 GTGRAQTFFDVSEPPPVIQVPNNV---TVTPGERAVLTCLIISAVDYNLTWQRNDRDVRL 562
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E ++ S L +K V ND EY C+ ++ G A++ L V PK+T +
Sbjct: 563 AEPARIRTLANLS--LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKN 620
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA-RVSS---LTL 372
+ +V++ C A+G P P I W T++ +V SH R++S L +
Sbjct: 621 QSFTGGSEVSIMCSATGYPKPKIAW------------TVNDMFIVGSHRYRMTSDGTLFI 668
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQVNITCEVF 429
K+ DAG Y C ASN+ G D Q+ L APKL Q + V G+ + C+
Sbjct: 669 KNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVAL--GDITVMECKTS 726
Query: 430 AYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
P + WF+ D +L PS+ + P L++ + D G+Y C A+N G+
Sbjct: 727 GIPPPQVKWFKGDLELRPST-----FLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 781
Query: 489 SLEFILVQADTP 500
+ + L P
Sbjct: 782 TGKITLDVGSPP 793
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 162 bits (410), Expect = 1e-39
Identities = 186/734 (25%), Positives = 287/734 (39%), Gaps = 89/734 (12%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ +GE++ P R+ +
Sbjct: 53 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 110
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
+ + D G Y CV G ++++ + F+ PT GE A++ C
Sbjct: 111 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 170
Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
P PTI WK K + I K+ R I + L I +K+D G Y C G + GE
Sbjct: 171 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 227
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ ++ V PT R +N ++V C +G P+PT+ W KD + +
Sbjct: 228 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 285
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+
Sbjct: 286 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 340
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373
+ VT CE G+P P++ W+ + L + + ++R S LT+
Sbjct: 341 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 395
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
+IQ +DAG YIC A G LEV LQGP + C
Sbjct: 396 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 455
Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
+ P ISW ++G P + + I+ T L + +D G Y C A +
Sbjct: 456 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 510
Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
G+ S +L +D P PS QV + + +P G +P
Sbjct: 511 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 570
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+
Sbjct: 571 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 627
Query: 593 FKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGGSPIRH 634
PV+ + +P +G Q+ ++ + V L D I+
Sbjct: 628 ----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQG 683
Query: 635 YLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAA 686
Y V YR S S W+ + ++P+ V++ +L YE+ V QG +
Sbjct: 684 YRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQGMDSES 742
Query: 687 HFVFRTSAQPTAIP 700
V T P+A P
Sbjct: 743 KTVRTTEEAPSAPP 756
Score = 53.9 bits (128), Expect = 6e-07
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ S++ LEV Q P V G
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 166
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TI W +D ++ I I L ++ ++D G Y C
Sbjct: 167 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 221
Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525
N +G+ + E + + T I+QV E QVQ D P+ T
Sbjct: 222 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 271
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 162 bits (410), Expect = 1e-39
Identities = 186/734 (25%), Positives = 287/734 (39%), Gaps = 89/734 (12%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ +GE++ P R+ +
Sbjct: 37 PSDVIVSKGEPTTLNCKAEG-RPTPTIEWYK-DGERVETDKDDPRSHRMLLPSGSLFFLR 94
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVIVC 139
+ + D G Y CV G ++++ + F+ PT GE A++ C
Sbjct: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
Query: 140 DVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
P PTI WK K + I K+ R I + L I +K+D G Y C G + GE
Sbjct: 155 QPPRGHPEPTIYWK-KDKVRIDDKEER-ISIRGGKLMISNTRKSDAGMYTCVGTNMV-GE 211
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ ++ V PT R +N ++V C +G P+PT+ W KD + +
Sbjct: 212 RDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
D K D L IKK DE Y+CIAEN+ G+ +A+ L V A P+
Sbjct: 270 YDIK-----DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLK 373
+ VT CE G+P P++ W+ + L + + ++R S LT+
Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQK-----EGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 379
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
+IQ +DAG YIC A G LEV LQGP + C
Sbjct: 380 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKC 439
Query: 427 EVFAYPSATISWFRDGQLLPSSN-YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
+ P ISW ++G P + + I+ T L + +D G Y C A +
Sbjct: 440 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI-----SDTGTYTCVATSSS 494
Query: 486 GQESLEFIL-------------VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
G+ S +L +D P PS QV + + +P G +P
Sbjct: 495 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 554
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E A + V +S W + T+ GL+P T Y + A+N +GL + S S+
Sbjct: 555 YIIE--AFSQSVSNS-WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 611
Query: 593 FKTQPVQGEPSAPKLEG----QMGEDGNSIKVNLIKQ--------------DDGGSPIRH 634
PV+ + +P +G Q+ ++ + V L D I+
Sbjct: 612 ----PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQG 667
Query: 635 YLVRYRALS-----SEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAA 686
Y V YR S S W+ + ++P+ V++ +L YE+ V QG +
Sbjct: 668 YRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQGMDSES 726
Query: 687 HFVFRTSAQPTAIP 700
V T P+A P
Sbjct: 727 KTVRTTEEAPSAPP 740
Score = 53.9 bits (128), Expect = 6e-07
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 19/231 (8%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQD-SQSMYLEVQYAPK--LQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ S++ LEV Q P V G
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TI W +D ++ I I L ++ ++D G Y C
Sbjct: 151 ILECQPPRGHPEPTIYWKKD-KVRIDDKEERISI----RGGKLMISNTRKSDAGMYTCVG 205
Query: 482 VNRIGQ---ESLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEPEAT 525
N +G+ + E + + T I+QV E QVQ D P+ T
Sbjct: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD-PQPT 255
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 155 bits (391), Expect = 2e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2685
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 2686 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 2744 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2799
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 2800 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2856
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2907
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 2908 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 2967
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 2968 IHWIKDGLPLRGSHLRH-QLQN----GSLTIRRTERDDAGRYQCLAENEMGVAKKVVILV 3022
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 3023 LQSAP----VFQVEPQDMTVR 3039
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 1762 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1815
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 1816 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1874
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 1875 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 1931
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 1991
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 1992 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 2050 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2102
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 2103 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2161
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 2162 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2212
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 1389 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1443
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 1444 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1503
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 1504 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1558
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1615
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 1616 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1675
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 1676 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1728
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 1729 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1788
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 1789 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1844
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 1845 ENPKTETVSQV 1855
Score = 136 bits (342), Expect = 9e-32
Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
L + A + G Y C + G+ S+ + V + ++ + PT + A +
Sbjct: 938 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R
Sbjct: 998 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056
Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E +
Sbjct: 1057 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
ED Y+ + L + + + D Y C+A N+AGE ++V P I + +
Sbjct: 1114 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1170
Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+++ + T L C +G P P +TW R ++ D H H + L+
Sbjct: 1171 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 1221
Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426
+Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C
Sbjct: 1222 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 1281
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G
Sbjct: 1282 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 487 QESLEFILVQADTPSSPSIDQVEP 510
E+++ V+ P PSI + +P
Sbjct: 1338 -EAVKNYHVEVLIP--PSISKDDP 1358
Score = 131 bits (329), Expect = 3e-30
Identities = 121/473 (25%), Positives = 187/473 (39%), Gaps = 28/473 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 626
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 627 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 686 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 741
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 742 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 800
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 801 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 853
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G + L V AP L+ + EG+ ++CE P IS
Sbjct: 854 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKIS 913
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 914 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 968
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 969 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 1021
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 1135 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1193
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 1194 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1250
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 1251 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1307
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 1308 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVK 1365
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1418
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 1419 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1478
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 1479 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1534
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 1535 GRYSCKASNEVGEDWLHYELLVLTPP 1560
Score = 130 bits (327), Expect = 5e-30
Identities = 114/431 (26%), Positives = 172/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2778
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 2779 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2837
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2888
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 2889 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 2943
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 2944 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 2991
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T++ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 2992 TIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3051
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 3052 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3106
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 3107 ARAFLVVRGEP 3117
Score = 129 bits (324), Expect = 1e-29
Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 2046 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2099
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 2100 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2151
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 2152 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2204
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2262
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 2263 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2314
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 2315 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2367
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 2368 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2427
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
L P S I P S L + P D G+Y C A N G +
Sbjct: 2428 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 120 bits (300), Expect = 7e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 2220 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2267
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 2268 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2326
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 2327 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2384
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 2385 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2439
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 2440 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2496
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 2497 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2551
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 2552 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 2612 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2667
Query: 501 SSP 503
P
Sbjct: 2668 VKP 2670
Score = 119 bits (297), Expect = 2e-26
Identities = 87/296 (29%), Positives = 124/296 (41%), Gaps = 31/296 (10%)
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS--- 266
VPP+I+ N + GQS+TL CDA GFP P + W KD + + Y +
Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 267 ---------DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYV-ENQ 316
D+ L ++ + D Y C AEN+AG HL V P + Q
Sbjct: 75 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 134
Query: 317 TAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG--HMVVRSHARVSSLTLK 373
+ L V L C SG P P + W + L G H+ V+ +V +T
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEW------TKDRQPVLPGGPHLQVQEDGQVLRITGS 188
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG---PVAVYTWEGNQVNITCEVFA 430
+ D G Y C A + GQ ++ L V P + G V E + V + CE
Sbjct: 189 HV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARG 246
Query: 431 YPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
P+ I+WF+DG LLP+S K+ T L++ +D G Y C A N +G
Sbjct: 247 VPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 298
Score = 114 bits (284), Expect = 5e-25
Identities = 105/452 (23%), Positives = 170/452 (37%), Gaps = 43/452 (9%)
Query: 51 DISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
D+ W G +L D +L D+G+Y C + G+ ++
Sbjct: 71 DLGWGQVGGHRLL------------DEGQSLHFPRIQEGDSGLYSCRAENQAGT-AQRDF 117
Query: 111 NVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIV 168
++ + A QE G D + C P + W + V+ +
Sbjct: 118 HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ 177
Query: 169 LSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLG 228
L+I G DEG Y+C A + +D Q+ V+ PPTI
Sbjct: 178 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMED 235
Query: 229 QSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICI 288
V L+C+A G P P ++W KDG + K +++ QL + + +D Y C
Sbjct: 236 HLVQLLCEARGVPTPNITWFKDGALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 292
Query: 289 AENKAGEQDATIHLKVFAKPKI------TYVENQTAMELEEQVTLTCEASGDPIPSITWR 342
A N G + L V+ P I YV A V L C A G P P+++W
Sbjct: 293 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWH 349
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
++ ++ R S L L+S +G Y C AS+ G+ +EV
Sbjct: 350 HEGLPVAESNES-------RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 402
Query: 403 QYAPKL---QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
Q P+L +G V T G + + C+ P TI W ++G+ P+ + +++
Sbjct: 403 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--AS 458
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
+ L + + G + C A N G E
Sbjct: 459 QGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490
Score = 110 bits (274), Expect = 7e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 228 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 281
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 282 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 341 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 397
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 398 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 455
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 456 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 514
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 515 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 572
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 573 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 632
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 633 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687
Score = 106 bits (264), Expect = 1e-22
Identities = 95/382 (24%), Positives = 162/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 2770 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2823
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 2824 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2882
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 2883 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 2932
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 2933 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 2987
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI++ +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 2988 NGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3047
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 3048 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3096
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 3097 VAHNLLGSATARAFLVVRGEPQ 3118
Score = 61.6 bits (148), Expect = 3e-09
Identities = 48/187 (25%), Positives = 75/187 (40%), Gaps = 22/187 (11%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEK-----------TLDGHMVVRSHARVSSLT 371
+ +TL C+A+G P+P I W + + + GH ++ SL
Sbjct: 34 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLH 90
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA---VYTWEGNQVNITCEV 428
IQ D+G Y C A N G + +L V P + G A V G V + C
Sbjct: 91 FPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWT 150
Query: 429 FAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
P+ + W +D Q +LP + ++ L +T D G Y C A + GQ
Sbjct: 151 SGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 488 ESLEFIL 494
++ +F L
Sbjct: 207 QARDFQL 213
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 154 bits (390), Expect = 3e-37
Identities = 193/733 (26%), Positives = 279/733 (38%), Gaps = 85/733 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
+Y DD + L I+KV D Y C+AEN G+ +A+ L V P
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372
+ L VT CEA+G+P P+I WR + L + +S +R S LT+
Sbjct: 322 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425
++Q +D G YIC N G YLEV P + QGPV ++
Sbjct: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 492
Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y E S W E I GLKP Y + A N G+ + S
Sbjct: 553 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609
Query: 591 SE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPIRHY 635
S+ KTQ P +++ ++G +SI+V+ D I+ Y
Sbjct: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGY 668
Query: 636 LVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAAH 687
+ YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 669 KILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIK 727
Query: 688 FVFRTSAQPTAIP 700
F P+A P
Sbjct: 728 FAKTLEEAPSAPP 740
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 154 bits (390), Expect = 3e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 2776
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 2835 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 2890
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 2891 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 2947
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 2998
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 2999 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 3058
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 3059 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 3113
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 3114 LQSAP----VFQVEPQDMTVR 3130
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 1853 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 1906
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 1907 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 1965
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 1966 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 2022
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 2082
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 2083 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 2141 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 2193
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 2194 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 2252
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 2253 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 2303
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 1480 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 1534
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 1535 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 1594
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 1595 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 1649
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 1706
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 1707 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 1766
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 1767 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 1819
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 1820 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 1879
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 1880 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 1935
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 1936 ENPKTETVSQV 1946
Score = 136 bits (342), Expect = 9e-32
Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
L + A + G Y C + G+ S+ + V + ++ + PT + A +
Sbjct: 1029 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R
Sbjct: 1089 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147
Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E +
Sbjct: 1148 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 1204
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
ED Y+ + L + + + D Y C+A N+AGE ++V P I + +
Sbjct: 1205 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 1261
Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+++ + T L C +G P P +TW R ++ D H H + L+
Sbjct: 1262 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 1312
Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426
+Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C
Sbjct: 1313 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 1372
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G
Sbjct: 1373 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 1428
Query: 487 QESLEFILVQADTPSSPSIDQVEP 510
E+++ V+ P PSI + +P
Sbjct: 1429 -EAVKNYHVEVLIP--PSISKDDP 1449
Score = 132 bits (331), Expect = 2e-30
Identities = 121/473 (25%), Positives = 189/473 (39%), Gaps = 28/473 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 718 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 777 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 832
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 833 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 891
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 892 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 944
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G+ + L V AP L+ + EG+ +++CE P IS
Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 1004
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 1005 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 1059
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 1060 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 1112
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 1226 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 1284
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 1285 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 1341
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 1342 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 1398
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 1399 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 1456
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 1509
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 1510 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 1569
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 1570 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 1625
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 1626 GRYSCKASNEVGEDWLHYELLVLTPP 1651
Score = 129 bits (324), Expect = 1e-29
Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 2137 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 2190
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 2191 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 2242
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 2243 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 2295
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 2353
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 2354 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 2405
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 2406 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 2458
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 2459 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 2518
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
L P S I P S L + P D G+Y C A N G +
Sbjct: 2519 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 129 bits (324), Expect = 1e-29
Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 2869
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 2870 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2928
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 2979
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 2980 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 3034
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 3035 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 3082
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 3083 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3142
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 3143 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 3197
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 3198 ARAFLVVRGEP 3208
Score = 120 bits (300), Expect = 7e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 2311 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 2358
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 2359 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 2417
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 2418 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 2475
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 2476 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 2530
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 2531 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 2587
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 2588 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 2642
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 2643 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 2703 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 2758
Query: 501 SSP 503
P
Sbjct: 2759 VKP 2761
Score = 112 bits (280), Expect = 1e-24
Identities = 121/485 (24%), Positives = 184/485 (37%), Gaps = 52/485 (10%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C G K + ++W + Q ++V+ +L + + + D+G Y+C T
Sbjct: 24 CGTHGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGDYECQATN 78
Query: 101 EDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI 159
E GS S A + V + + G+ + CD P I+W + V
Sbjct: 79 EVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 160 LKKDVRFIVLSNNYLQIRGIKKTDEGTY----RCE-GRILARGEINFKDIQVIVN----- 209
+ + Q+ G + DEG R + GR RG Q
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGL 198
Query: 210 ---------------VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
PP++ G V L C G P P + WTKD + +
Sbjct: 199 AGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPV 258
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
+D L I DE Y C+A + AG+Q L+V A P I +
Sbjct: 259 --LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGS 315
Query: 315 NQT---AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
N+T A+ + V L CEA G P P+ITW + + K +V R L
Sbjct: 316 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQ 368
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCE 427
L Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECV 428
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
+PS T+SW +G + SN S ++ S L + E G Y+C A + G+
Sbjct: 429 ARGHPSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGE 484
Query: 488 ESLEF 492
L++
Sbjct: 485 AVLQY 489
Score = 110 bits (274), Expect = 7e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 319 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 372
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 432 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 488
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 489 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 546
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 547 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 605
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 606 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 663
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 664 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 723
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 724 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Score = 108 bits (271), Expect = 2e-23
Identities = 91/369 (24%), Positives = 144/369 (39%), Gaps = 28/369 (7%)
Query: 132 GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG 191
G D + C P + W + V+ + L+I G DEG Y+C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 192 RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG 251
A + +D Q+ V+ PPTI V L+C+A G P P ++W KDG
Sbjct: 292 FSPAGQQA--RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349
Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI- 310
+ K +++ QL + + +D Y C A N G + L V+ P I
Sbjct: 350 ALL---PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 406
Query: 311 -----TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
YV A V L C A G P P+++W ++ ++ R
Sbjct: 407 GAGGRPYVVKAVA---GRPVALECVARGHPSPTLSWHHEGLPVAESNES-------RLET 456
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGNQV 422
S L L+S +G Y C AS+ G+ +EVQ P+L +G V T G +
Sbjct: 457 DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPL 516
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
+ C+ P TI W ++G+ P+ + +++ + L + + G + C A
Sbjct: 517 ELPCQASGSPVPTIQWLQNGR--PAEELAGVQV--ASQGTTLHIDHVELDHSGLFACQAT 572
Query: 483 NRIGQESLE 491
N G E
Sbjct: 573 NEAGTAGAE 581
Score = 105 bits (261), Expect = 2e-22
Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 2861 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 2914
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 2915 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 2973
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 2974 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 3023
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 3024 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 3078
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI + +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 3079 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 3138
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 3139 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 3187
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 3188 VAHNLLGSATARAFLVVRGEPQ 3209
Score = 102 bits (255), Expect = 1e-21
Identities = 107/441 (24%), Positives = 183/441 (41%), Gaps = 42/441 (9%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
+ L I +++ D G Y+CV G ++ + + V + N E
Sbjct: 269 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 328
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFI-VLSNNYLQIRGIKKTDEGTYRCE-GR 192
++C+ P I W G +L + + LQ+ + +D G Y C+
Sbjct: 329 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 386
Query: 193 ILARGEINFKDIQVIVNVPPTIQ---ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW
Sbjct: 387 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 441
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G + + + D S L ++ + Y C+A + AGE ++V P+
Sbjct: 442 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 498
Query: 310 ITYVE--NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+ E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 551
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424
++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + +
Sbjct: 552 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 610
Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473
+ P W +G P S + + I + Y+ P L++ D
Sbjct: 611 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 668
Query: 474 FGNYNCTAVNRIGQESLEFIL 494
G Y C A N G+ E L
Sbjct: 669 EGIYTCAATNLAGESKREVAL 689
Score = 35.4 bits (80), Expect = 0.22
Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G V + C P+ + W +D Q +LP + ++ L +T D G Y
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQ----EDGQVLRITGSHVGDEGRY 287
Query: 478 NCTAVNRIGQESLEFIL 494
C A + GQ++ +F L
Sbjct: 288 QCVAFSPAGQQARDFQL 304
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 154 bits (390), Expect = 3e-37
Identities = 119/441 (26%), Positives = 184/441 (41%), Gaps = 30/441 (6%)
Query: 78 SSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVI 137
S L I A AG Y C G + V + + + K P+ E+ ++
Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGV-AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLL 3967
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C+ PTI W+ +G +V + VL L+I D G Y C + A
Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQ--VLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ +++V VPP I+ + + + G L C A G PEP ++W KDG+ +
Sbjct: 4026 AMG--KTRLVVQVPPVIE--NGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA 4081
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
E K+ S +L +K ++ D Y C AEN G +HL + P T +
Sbjct: 4082 EG--KFTIQP-SGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR 4138
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
++ L +++ L C A G P P I W + R ++ DG S+L ++
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGG---------STLQRAAVSR 4189
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE--GNQVNITCEVFAYPSAT 435
D+G Y+C A N +G+ ++ V+ AP LQG Y E G + + C V P
Sbjct: 4190 EDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 4249
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
I W +DG L S+ + ++ N L + +D G Y C A N +G ILV
Sbjct: 4250 IHWIKDGLPLRGSHLRH-QLQN----GSLTIHRTERDDAGRYQCLAENEMGVAKKVVILV 4304
Query: 496 QADTPSSPSIDQVEPYSSTAQ 516
P + QVEP T +
Sbjct: 4305 LQSAP----VFQVEPQDMTVR 4321
Score = 148 bits (374), Expect = 2e-35
Identities = 129/479 (26%), Positives = 204/479 (42%), Gaps = 37/479 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ VG+ C+ + ++W+ +G+ L Q+ ++ L I A + D
Sbjct: 3044 VRVGDKAVLSCETDA-LPEPTVTWYK-DGQPLVLAQRTQAL----RGGQRLEIQEAQVSD 3097
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR-EGEDAVIVCDVVSSLPPTI 149
G+Y C V+ G E+ T + + F+N T + G V+ CDV PT+
Sbjct: 3098 KGLYSCKVSNVAG-EAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTV 3156
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVN 209
W K R + V +V LQ+ ++ GTY C + E KD V V
Sbjct: 3157 TWL-KDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAEN-TQAEAR-KDFVVAVL 3213
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
V P I++ GQ V L C+A+G P P ++W KDG + Q+ + D
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG 3273
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIH-LKVFAKPKITYVENQTAMELE---EQV 325
S L +K + +D Y C+A N AGE DA +H + V P I + + + E V
Sbjct: 3274 S-LVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+ C G P ++W + ++TL H +L + +Q DAG + C
Sbjct: 3332 TMVCPVRGSPPIHVSWLKDGLPLPLSQRTL-------LHGSGHTLRISKVQLADAGIFTC 3384
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVA----VYTWEGNQVNITCEVFAYPSATISWFRD 441
A++ G ++ L+VQ P L+ PV V G+ V + CE P +SW +D
Sbjct: 3385 VAASPAGVADRNFTLQVQVPPVLE-PVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD 3443
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
G+ L S + + PS L++ D G Y+C AV+ G+ F L + P
Sbjct: 3444 GEPLLSQS-----LEQGPS---LQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPP 3494
Score = 147 bits (371), Expect = 4e-35
Identities = 128/491 (26%), Positives = 217/491 (44%), Gaps = 58/491 (11%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT---GEDGSESEA 108
I W+ +G+ +TP+ R+ V+ L I + D+G Y CV T GED +
Sbjct: 2671 IRWYK-DGQPVTPSS-RLQVL---GEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNV 2725
Query: 109 TVNVK-IFQKL-----MFKNAPTPQEFR----------EGEDAVIVCDVVSSLPPTIIWK 152
+ V +FQK+ F+ +E R E A + CD + PP + W
Sbjct: 2726 LIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWY 2785
Query: 153 HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI--NFKDIQVIVNV 210
+ + + +V ++ LQI ++ + G Y C+ A E+ ++ +++V
Sbjct: 2786 REDQPLSAGDEVS-VLQGGRVLQIPLVRAENAGRYSCK----ASNEVGEDWLHYELLVLT 2840
Query: 211 PPTI--QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
PP I + + T N +V+L C A G P PT+SW ++G + +D
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSP---RLQVLED 2897
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-NQTAMELEEQVTL 327
L + + D A Y+C+AEN+AG + L+V P+I ++ Q L V+L
Sbjct: 2898 GQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSL 2957
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 387
C+ P P +TW ++ +S E+ ++ +H +L L + +D+G Y C A
Sbjct: 2958 PCDVHAHPNPEVTWYKDSQALSLGEEVF---LLPGTH----TLQLGRARLSDSGMYTCEA 3010
Query: 388 SNTIGQDSQSMYLEVQYAPKL----QGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDG 442
N G+D + + L V P +GP AV G++ ++CE A P T++W++DG
Sbjct: 3011 LNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDG 3070
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-VQA---- 497
Q L + + LE+ +D G Y+C N G+ F L VQ
Sbjct: 3071 QPLVLAQ----RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTF 3126
Query: 498 DTPSSPSIDQV 508
+ P + ++ QV
Sbjct: 3127 ENPKTETVSQV 3137
Score = 144 bits (363), Expect = 3e-34
Identities = 132/498 (26%), Positives = 203/498 (40%), Gaps = 52/498 (10%)
Query: 12 FFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISV 71
+ LG V QV P ++ VGE+ C G+ + + +SW S +G L + SV
Sbjct: 1112 YVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ-LSW-SKDGVVLQGRGPQGSV 1169
Query: 72 VWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQ--EF 129
+ +S DAG Y+C + G ++ V +++ + + T E
Sbjct: 1170 HFAAIRTS----------DAGRYRCEASNSAGVDAWE-VELRVLEPPHWGADETSGLLER 1218
Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 189
GE+A + C + P + W+ L VL L + + D G Y C
Sbjct: 1219 VAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278
Query: 190 EGRILARGEINF--KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
+ A E+ + +++V VPP+I+ N + GQS+TL CDA GFP P + W
Sbjct: 1279 Q----ATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334
Query: 248 TKDGEQIEQEEDDEKYIFS------------DDSSQLTIKKVDKNDEAEYICIAENKAGE 295
KD + + Y + D+ L ++ + D Y C AEN+AG
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGT 1394
Query: 296 QDATIHLKVFAKPKITYV-ENQTAMELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEK 353
HL V P + Q + L V L C SG P P + W +
Sbjct: 1395 AQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW------TKDRQP 1448
Query: 354 TLDG--HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG- 410
L G H+ V+ +V +T + D G Y C A + GQ ++ L V P + G
Sbjct: 1449 VLPGGPHLQVQEDGQVLRITGSHV--GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGS 1506
Query: 411 --PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468
V E + V + CE P+ I+WF+DG LLP+S K+ T L++
Sbjct: 1507 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST----KVVYTRGGRQLQLGR 1562
Query: 469 DSENDFGNYNCTAVNRIG 486
+D G Y C A N +G
Sbjct: 1563 AQSSDAGVYTCKASNAVG 1580
Score = 140 bits (354), Expect = 4e-33
Identities = 137/488 (28%), Positives = 197/488 (40%), Gaps = 49/488 (10%)
Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST 80
QV I S S G C +G ISW + + RI V D+ T
Sbjct: 609 QVSIHTSSQHFSQGVEVKVSCSASG-YPTPHISWSRES--QALQEDSRIHV----DAQGT 661
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE------GED 134
L I +DAG Y C T E G++ E L + + P+ GE+
Sbjct: 662 LIIQGVAPEDAGNYSCQATNEVGTDQETVT-------LYYTDPPSVSAVNAVVLVAVGEE 714
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRIL 194
AV+VC+ PP +IW G ++IL + S+ L+I ++ D GTY C
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYTCR---- 766
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK-DGEQ 253
A E+ ++ + V Q + + T LG+S L C A G P PT++W + DG+
Sbjct: 767 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826
Query: 254 IEQEEDDEKYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV--FAKPK 309
+ + S DS L + V D+A Y+C A N G+ A L V A P+
Sbjct: 827 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886
Query: 310 ITYVENQTAMELEEQVTLTCEA-SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368
I + + V+L C +G P+P W R + + S
Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSR--------HSIRADG 938
Query: 369 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY--TWEGNQVNITC 426
SL L AG Y C A+NT G + + L VQ P++ P A + T EG ++ C
Sbjct: 939 SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIH-PTATHHITNEGVPASLPC 997
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
P+ TI+W ++ L S YN L + S D G Y CTA N +G
Sbjct: 998 VASGVPAPTITWTKETNALTSRGPH----YNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 1053
Query: 487 QESLEFIL 494
S E L
Sbjct: 1054 FSSQEMRL 1061
Score = 136 bits (342), Expect = 9e-32
Identities = 114/444 (25%), Positives = 195/444 (43%), Gaps = 37/444 (8%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESE-ATVNVKIFQKLMF-KNAPTPQEFREGEDAVIV 138
L + A + G Y C + G+ S+ + V + ++ + PT + A +
Sbjct: 2220 LYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA-RG 197
C+ PPT+ W+ G+ V + ++ + L + + G Y C LA R
Sbjct: 2280 CNATGKPPPTVTWERDGQPVGAELGLQ-LQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338
Query: 198 EINFKDIQVIVNVPPTIQARQN-IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
E F ++ V VPP + + + N TA L +TL+C+A G P P + W + E +
Sbjct: 2339 ERKF---ELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
ED Y+ + L + + + D Y C+A N+AGE ++V P I + +
Sbjct: 2396 GED--TYLLA-GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLE 2452
Query: 317 TAMELEEQVT--LTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+++ + T L C +G P P +TW R ++ D H H + L+
Sbjct: 2453 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARG----DAH-----HISPDGVLLQV 2503
Query: 375 IQ--YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPV------AVYTWEGNQVNITC 426
+Q + AG Y C A+N +G+ ++ L V AP + G V N +++ C
Sbjct: 2504 LQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLIC 2563
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
E A+PS I+W +DG +S NI++ P L++ + D G Y C N +G
Sbjct: 2564 EALAFPSPNITWMKDGAPFEASR--NIQL--LPGTHGLQILNAQKEDAGQYTCVVTNELG 2619
Query: 487 QESLEFILVQADTPSSPSIDQVEP 510
E+++ V+ P PSI + +P
Sbjct: 2620 -EAVKNYHVEVLIP--PSISKDDP 2640
Score = 131 bits (330), Expect = 2e-30
Identities = 121/473 (25%), Positives = 188/473 (39%), Gaps = 28/473 (5%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I ++ D GIY C T G ES+ V +K+ + P + E + C
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAG-ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECL 1908
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC-EGRILARGEI 199
PP + W KG + + + L+I + +D G+YRC + E+
Sbjct: 1909 ASGVPPPDVSW-FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + VNVPP I ++ + V L C+A G P PT+ W KDG +
Sbjct: 1968 RYG---LRVNVPPRITLPPSLPGPVL-VNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGT 2023
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+F LT+ +D Y C+A + GE + L+V P I E ++
Sbjct: 2024 PGLQVFPG-GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSV 2082
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E V L C++ P P ++W + + L+ V A + L + D
Sbjct: 2083 VANESVALECQSHAMPPPVLSW-------WKDGRPLEPRPGVHLSADKALLQVDRADVWD 2135
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP--KLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
AG Y C A N G + L V AP L+ + EG+ +++CE P IS
Sbjct: 2136 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 2195
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
W +DGQ LP + YL ++ G Y C N +G S + +Q
Sbjct: 2196 WRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQE--GTYTCECSNVVGNSSQD---LQL 2250
Query: 498 DTPSSPSI-DQVEPYSSTAQVQFD----EPEATG-GVPILKYKAEWRAVGEEV 544
+ P I EP + + VQ E ATG P + ++ + + VG E+
Sbjct: 2251 EVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAEL 2303
Score = 131 bits (329), Expect = 3e-30
Identities = 106/446 (23%), Positives = 186/446 (41%), Gaps = 55/446 (12%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR--EGEDAVIVCDVVSSLPP 147
D+G+Y C+ + E G E+ +V++ +N + + +G+ A ++C+V P
Sbjct: 2417 DSGLYSCLASNEAG-EARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQP 2475
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
+ W GR + + D I LQ+ + G Y C A GE K Q+
Sbjct: 2476 KLTWFKDGRP-LARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN-AVGE-KTKHFQLS 2532
Query: 208 VNVPPTI-----QARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V + PTI + V T N ++L+C+A FP P ++W KDG E + +
Sbjct: 2533 VLLAPTILGGAEDSADEEVTVTVN--NPISLICEALAFPSPNITWMKDGAPFEASRNIQ- 2589
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE-------N 315
+ L I K D +Y C+ N+ GE H++V P I+ +
Sbjct: 2590 --LLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVK 2647
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ ++ +TL CE+ P P+I W + ++ + + V R+ L ++
Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSR-----LQVLGEGRL--LQIQPT 2700
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-------------------GPVAVY- 415
Q +D+G Y+C A+N G+D Q + +Q P Q G V Y
Sbjct: 2701 QVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR 2760
Query: 416 -TWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
E N + C+ A P ++W+R+ Q L + + ++ L++ +
Sbjct: 2761 EIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSV----LQGGRVLQIPLVRAENA 2816
Query: 475 GNYNCTAVNRIGQESLEFILVQADTP 500
G Y+C A N +G++ L + L+ P
Sbjct: 2817 GRYSCKASNEVGEDWLHYELLVLTPP 2842
Score = 130 bits (327), Expect = 5e-30
Identities = 120/473 (25%), Positives = 199/473 (42%), Gaps = 37/473 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ C+V G+A +++W + L + R++ + + +L I D
Sbjct: 528 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 581
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G Y+CV + +G + A+V + + + + Q F +G + + C P I
Sbjct: 582 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 640
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
W + + L++D R V + L I+G+ D G Y C+ A E+ + + +
Sbjct: 641 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 694
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
PP++ A +V +G+ LVC+A G P P + W + G E I E
Sbjct: 695 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 745
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S +L I + D Y C A N+ G+ A I L V P++T + +EL L
Sbjct: 746 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 805
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386
C A+G P P++TWR L RS S L +S+ D Y+C
Sbjct: 806 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 863
Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442
A N G+ +++ + +AP V EG V++ C V A P W +DG
Sbjct: 864 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ LP + +I+ + L + + G Y+C A N G + + LV
Sbjct: 924 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV 971
Score = 129 bits (324), Expect = 1e-29
Identities = 124/481 (25%), Positives = 194/481 (40%), Gaps = 43/481 (8%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE+ C G K + ++W + Q ++V+ +L + + + D+G
Sbjct: 1221 GENASLPCPARGTPKPQ-VTWRKGPSSEPLHGQPGVAVL----EEGSLFLASVSPADSGD 1275
Query: 94 YKCVVTGEDGSESE-ATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
Y+C T E GS S A + V + + G+ + CD P I+W
Sbjct: 1276 YECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWL 1335
Query: 153 HKGRDVILKK-------DVRFIVLSNNYLQIRG-------IKKTDEGTYRCEGRILARGE 198
+ V + D+ + + + L G I++ D G Y C A G
Sbjct: 1336 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQA-GT 1394
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+D ++V PP++ G V L C G P P + WTKD + +
Sbjct: 1395 AQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGG 1453
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT- 317
+ +D L I DE Y C+A + AG+Q L+V A P I + N+T
Sbjct: 1454 PHLQV--QEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTI-WGSNETG 1510
Query: 318 --AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
A+ + V L CEA G P P+ITW + + K +V R L L
Sbjct: 1511 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTK-----VVYTRGGR--QLQLGRA 1563
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQG----PVAVYTWEGNQVNITCEVFAY 431
Q +DAG Y C ASN +G ++ L+V P ++G P V G V + C +
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGH 1623
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
PS T+SW +G + SN S ++ S L + E G Y+C A + G+ L+
Sbjct: 1624 PSPTLSWHHEGLPVAESNESRLE----TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679
Query: 492 F 492
+
Sbjct: 1680 Y 1680
Score = 129 bits (324), Expect = 1e-29
Identities = 123/468 (26%), Positives = 194/468 (41%), Gaps = 56/468 (11%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GE +C V G + +SW +G L +Q+ + S TL I + DAGI
Sbjct: 3328 GELVTMVCPVRG-SPPIHVSWLK-DGLPLPLSQRTLL----HGSGHTLRISKVQLADAGI 3381
Query: 94 YKCVVTGEDG-SESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP------ 146
+ CV G ++ T+ V++ L P EF+ D V+V + LP
Sbjct: 3382 FTCVAASPAGVADRNFTLQVQVPPVL------EPVEFQN--DVVVVRGSLVELPCEARGV 3433
Query: 147 --PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI 204
P + W G ++ + + LQ+ + D GTY C + GE +
Sbjct: 3434 PLPLVSWMKDGEPLLSQS-----LEQGPSLQLEAVGAGDSGTYSCVA-VSEAGEAR-RHF 3486
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
Q+ V PP I+ + G + L+CDA+G P+P ++W KDG+ + + E++ +
Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSR-- 3544
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME--LE 322
+ + D Y C+AE+ AG + + ++V A P I +
Sbjct: 3545 --------ATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAP 3596
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
Q+ L C +P P ITW I +E D H R L L+++ D+G+
Sbjct: 3597 GQLVLECSVEAEPAPKITWHRD--GIVLQE---DAHTQFPERGRF--LQLQALSTADSGD 3649
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y CTA N G S + +E+ P ++ GP AV + C+ P+ +SW +D
Sbjct: 3650 YSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD 3709
Query: 442 G-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
L P S I P S L + P D G+Y C A N G +
Sbjct: 3710 RVPLDPRSPRFEI----LPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 129 bits (324), Expect = 1e-29
Identities = 114/431 (26%), Positives = 171/431 (39%), Gaps = 44/431 (10%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
L I +A+ +DAG Y C+ GS T + + + +N EG A + C
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKT-RLVVQVPPVIENGLPDLSTTEGSHAFLPCK 4060
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
S P I W G+ V + +F + + L ++ ++ D GTY C GR
Sbjct: 4061 ARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 4119
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
R + + V +P R LG + L C A G P P + WT + +
Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLR---------LGDRLWLRCAARGSPTPRIGWTVNDRPVT 4170
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ ++ D S L V + D Y+C AEN+ G A + V P +
Sbjct: 4171 EGVSEQ-----DGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF 4225
Query: 316 QTAME-LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS----SL 370
+E + + L C GDP+P I W DG + SH R SL
Sbjct: 4226 SYLVEPVGGSIQLDCVVRGDPVPDIHW------------IKDGLPLRGSHLRHQLQNGSL 4273
Query: 371 TLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVF 429
T+ + DAG Y C A N +G + + L +Q AP Q P + G+ V + C+
Sbjct: 4274 TIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 4333
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
P+ TI W + GQ L +S ++ P S L + D G Y+C A N +G +
Sbjct: 4334 GEPTPTIEWLQAGQPLRASR----RLRTLPDGS-LWLENVETGDAGTYDCVAHNLLGSAT 4388
Query: 490 LEFILVQADTP 500
LV P
Sbjct: 4389 ARAFLVVRGEP 4399
Score = 120 bits (300), Expect = 7e-27
Identities = 116/483 (24%), Positives = 194/483 (40%), Gaps = 37/483 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P++ ++ G LC G + +I+W +G+ LT + ++S +T +
Sbjct: 3502 PTELSLTPGAPMELLCDAQGTPQP-NITWHK-DGQALTRLE--------NNSRATRVL-- 3549
Query: 86 ANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS 144
+ DAG+Y C+ G+ E V V+ ++ P V+ C V +
Sbjct: 3550 -RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAE 3608
Query: 145 LPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARG-EINFK 202
P I W G ++L++D +LQ++ + D G Y C R A + F+
Sbjct: 3609 PAPKITWHRDG--IVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFR 3666
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V ++ PTI++ VN + N Q+ L C A+G P P +SW KD ++ +
Sbjct: 3667 ---VEIHTVPTIRSGPPAVNVSVN--QTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE 3721
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE 322
+ L I+ V D Y+C+A N AG L+V P I + +
Sbjct: 3722 IL---PEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAH 3778
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
L CEASG P P + W + + + + ++ S+A L L + D+ +
Sbjct: 3779 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQ-GAYRLLPSNA----LLLTAPGPQDSAQ 3833
Query: 383 YICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSATISWFRD 441
+ C SN +G+ + + V P + +T V +TC P+ T+SW +
Sbjct: 3834 FECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQADTP 500
G L + Y + LE+ G Y C+A N G F+ VQA
Sbjct: 3894 GAQLGARGSG----YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPV 3949
Query: 501 SSP 503
P
Sbjct: 3950 VKP 3952
Score = 113 bits (282), Expect = 8e-25
Identities = 118/471 (25%), Positives = 179/471 (38%), Gaps = 72/471 (15%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
++VGE +C+ +G + I W+ E + + SS L I A D
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 759
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
AG Y C E G S A + + + P G A++ C PPT+
Sbjct: 760 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 818
Query: 151 WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
W+ G+ + L+ + R + L + D+ Y CE R + G++ +
Sbjct: 819 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 877
Query: 206 VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263
++ + PP I + V GQ V+L C G P P W KDG + ++
Sbjct: 878 IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 932
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
D S L + + + Y C+A N AG Q + L V P+I
Sbjct: 933 SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 991
Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
+L C ASG P P+ITW T ++S H V ++ +L + DAG Y
Sbjct: 992 PASLPCVASGVPAPTITWTKETNALTSRGP----HYNV---SKEGTLLIAQPSAQDAGAY 1044
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
+CTA+NT+G SQ M L V + ++ Y WE +
Sbjct: 1045 VCTATNTVGFSSQEMRLSVN-----RLALSKYVWE----------------------EYG 1077
Query: 444 LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
LLPS + L + D G+Y CTA N G S ++L
Sbjct: 1078 LLPSGS--------------LRLAQVQVGDSGHYECTASNPAGSASHRYVL 1114
Score = 110 bits (274), Expect = 7e-24
Identities = 111/479 (23%), Positives = 188/479 (39%), Gaps = 34/479 (7%)
Query: 29 GEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNA 86
GE++V E LC+ G +I+WF L P ++ L + A
Sbjct: 1510 GEVAVMEDHLVQLLCEARG-VPTPNITWFKDGA--LLPTSTKVVYT---RGGRQLQLGRA 1563
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA---PTPQEFREGEDAVIVCDVVS 143
DAG+Y C + G+ +AT + ++ + A P + G + C
Sbjct: 1564 QSSDAGVYTCKASNAVGAAEKAT-RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622
Query: 144 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
PT+ W H+G V + R + + L++ + G Y C A GE +
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESR-LETDGSVLRLESPGEASSGLYSCVASSPA-GEAVLQ- 1679
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
V V VPP + + + T +GQ + L C A G P PT+ W ++G E+ +
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ-- 1737
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVE-NQTAME 320
+ + L I V+ + + C A N+AG A + + V + P + V Q
Sbjct: 1738 -VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWG 1796
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM------VVRSHARVSSLTLKS 374
E + A+ DP W + E G + + +++ L ++
Sbjct: 1797 XEHHSSF--PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEK 1854
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPS 433
+ D G Y C A+N G+ + + L+V P ++ GPV E V + C P
Sbjct: 1855 VDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPP 1914
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+SWF+ Q P S++ + + + L + +D G+Y C A N G L +
Sbjct: 1915 PDVSWFKGHQ--PVSSWMGVTV--SVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969
Score = 108 bits (270), Expect = 2e-23
Identities = 127/523 (24%), Positives = 191/523 (36%), Gaps = 92/523 (17%)
Query: 77 SSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEF--REGED 134
+ +L + A + AG Y CV T GS+ +V++ ++ + PT EG
Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTAGSQHR---DVELVVQVPPRIHPTATHHITNEGVP 992
Query: 135 AVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC---- 189
A + C V S +P PTI W K + + + + V L I D G Y C
Sbjct: 993 ASLPC-VASGVPAPTITWT-KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 190 ------------------------EGRILARGEINFKDIQVI------------------ 207
E +L G + +QV
Sbjct: 1051 TVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASH 1110
Query: 208 -----VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
V VPP +Q ++ +G+++ L C AEG PEP +SW+KDG ++
Sbjct: 1111 RYVLGVQVPPQVQPGPRVLKVL--VGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-- 320
F+ + +D Y C A N AG + L+V P E +E
Sbjct: 1169 VHFA---------AIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
E +L C A G P P +TWR + SSE L G V + SL L S+ D+
Sbjct: 1220 AGENASLPCPARGTPKPQVTWR---KGPSSEP--LHGQPGV-AVLEEGSLFLASVSPADS 1273
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGP---VAVYTWEGNQVNITCEVFAYPSATIS 437
G+Y C A+N +G S+ L V P ++ V G + + C+ +P I
Sbjct: 1274 GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333
Query: 438 WFRDGQLLP----------SSNYSNIKIYNT-PSASYLEVTPDSENDFGNYNCTAVNRIG 486
W +D QL+ + + + L E D G Y+C A N+ G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVP 529
+F L+ PS + A + T GVP
Sbjct: 1394 TAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVP 1436
Score = 108 bits (270), Expect = 2e-23
Identities = 110/461 (23%), Positives = 181/461 (39%), Gaps = 40/461 (8%)
Query: 55 FSPNGEKLTPNQQRIS-VVWNDDS---SSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
FS +L+ N+ +S VW + S +L + + D+G Y+C + GS S V
Sbjct: 1054 FSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1113
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+ + + P + GE + C + P + W G V+L+
Sbjct: 1114 -LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDG--VVLQGRG-----P 1165
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
+ I+ +D G YRCE A ++ ++++ V PP A + G++
Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSA--GVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
+L C A G P+P ++W K G E ++ S L + V D +Y C A
Sbjct: 1224 ASLPCPARGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQAT 1281
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNI 348
N+ G L V+ P I + + + +TL C+A+G P+P I W + +
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341
Query: 349 SSE-----------EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
+ GH ++ SL IQ D+G Y C A N G +
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEG---QSLHFPRIQEGDSGLYSCRAENQAGTAQRD 1398
Query: 398 MYLEVQYAPKLQGPVA---VYTWEGNQVNITCEVFAYPSATISWFRDGQ-LLPSSNYSNI 453
+L V P + G A V G V + C P+ + W +D Q +LP + +
Sbjct: 1399 FHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQV 1458
Query: 454 KIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ L +T D G Y C A + GQ++ +F L
Sbjct: 1459 Q----EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQL 1495
Score = 107 bits (268), Expect = 4e-23
Identities = 90/366 (24%), Positives = 148/366 (40%), Gaps = 25/366 (6%)
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
++ C V S+LP + + + + L ++ F N+ +I K +EGTY C +
Sbjct: 445 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 501
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G K V+ + PP + N+ T + G++ L C G ++W +D +
Sbjct: 502 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 558
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ L I + D Y C+A N G A++ L V P+++ +
Sbjct: 559 ASTGRVAQLAD---LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 615
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+V ++C ASG P P I+W S E + L + A+ +L ++ +
Sbjct: 616 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 667
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSA 434
DAG Y C A+N +G D +++ L P + AV G + + CE P
Sbjct: 668 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 727
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ W+R G + I S+ L + E D G Y C AVN +G S E L
Sbjct: 728 RVIWYRGGLEM-------ILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780
Query: 495 VQADTP 500
P
Sbjct: 781 AVGHAP 786
Score = 105 bits (261), Expect = 2e-22
Identities = 95/382 (24%), Positives = 161/382 (42%), Gaps = 41/382 (10%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G F C+ G + + +I+W +G+ ++ + + ++ S L + N DAG
Sbjct: 4052 GSHAFLPCKARG-SPEPNITW-DKDGQPVSGAEGKFTI----QPSGELLVKNLEGQDAGT 4105
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G + V++ I +F P + R G+ + C S P I W
Sbjct: 4106 YTCTAENAVG-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTV 4164
Query: 154 KGRDV---ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILARGEINFKDIQVIV 208
R V + ++D + LQ + + D GTY C E R+ ++F V V
Sbjct: 4165 NDRPVTEGVSEQD------GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF----VHV 4214
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P +Q + +G S+ L C G P P + W KDG + +
Sbjct: 4215 KEAPVLQG-EAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQL----Q 4269
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ LTI + +++D Y C+AEN+ G + L + + P + + V L
Sbjct: 4270 NGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALR 4329
Query: 329 CEASGDPIPSITWRTSTRNI--SSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
C+A+G+P P+I W + + + S +TL DG SL L++++ DAG Y C
Sbjct: 4330 CQATGEPTPTIEWLQAGQPLRASRRLRTLPDG-----------SLWLENVETGDAGTYDC 4378
Query: 386 TASNTIGQDSQSMYLEVQYAPK 407
A N +G + +L V+ P+
Sbjct: 4379 VAHNLLGSATARAFLVVRGEPQ 4400
Score = 102 bits (255), Expect = 1e-21
Identities = 107/441 (24%), Positives = 183/441 (41%), Gaps = 42/441 (9%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGED 134
+ L I +++ D G Y+CV G ++ + + V + N E
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL 1519
Query: 135 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRCEG-R 192
++C+ P I W G +L + + LQ+ + +D G Y C+
Sbjct: 1520 VQLLCEARGVPTPNITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577
Query: 193 ILARGEINFKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ E K ++ V VPPTI+ R +V A A G+ V L C A G P PT+SW
Sbjct: 1578 AVGAAE---KATRLDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPTLSWHH 1632
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G + + + D S L ++ + Y C+A + AGE ++V P+
Sbjct: 1633 EGLPVAESNESR---LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQ 1689
Query: 310 ITYVEN--QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
+ E Q + + + L C+ASG P+P+I W + R +EE L G V+ ++
Sbjct: 1690 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR--PAEE--LAG---VQVASQG 1742
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAP-KLQGPVAVYTWEGNQVNI 424
++L + ++ +G + C A+N G + + V ++AP L+ P+ Y W G + +
Sbjct: 1743 TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW-GXEHHS 1801
Query: 425 TCEVFAYPSATISW-------FRDGQLLPSSNY---SNIKI-YNTPSASYLEVTPDSEND 473
+ P W +G P S + + I + Y+ P L++ D
Sbjct: 1802 SFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP--LQIEKVDLRD 1859
Query: 474 FGNYNCTAVNRIGQESLEFIL 494
G Y C A N G+ E L
Sbjct: 1860 EGIYTCAATNLAGESKREVAL 1880
Score = 89.0 bits (219), Expect = 2e-17
Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%)
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+E++ +S I + K +E Y C A ++AG A + V P +
Sbjct: 469 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 528
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374
E L+C G+ ++TW D ++ S RV+ SL +
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 576
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429
I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C
Sbjct: 577 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 632
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G +
Sbjct: 633 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 687
Query: 490 LEFILVQADTPSSPSIDQV 508
L D PS +++ V
Sbjct: 688 ETVTLYYTDPPSVSAVNAV 706
Score = 43.5 bits (101), Expect = 8e-04
Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%)
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 426
SS + + G Y CTA + G + V P P T G ++C
Sbjct: 479 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 538
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
V ++W RD ++LP+S ++ + LE++ D G Y C A N G
Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 594
Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546
L+ + P + +S +V+ + P + + E +A+ E+
Sbjct: 595 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 651
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+G + I G+ PE A N G + + + P
Sbjct: 652 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 698
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 154 bits (390), Expect = 3e-37
Identities = 193/733 (26%), Positives = 279/733 (38%), Gaps = 85/733 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 74 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 131
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 132 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 190
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 191 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 247
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 248 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQT 317
+Y DD + L I+KV D Y C+AEN G+ +A+ L V P
Sbjct: 306 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTL 372
+ L VT CEA+G+P P+I WR + L + +S +R S LT+
Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWRR-----EGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQVNIT 425
++Q +D G YIC N G YLEV P + QGPV ++
Sbjct: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 476 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIASTPS 531
Query: 486 GQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPI 530
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591
Query: 531 LKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y E S W E I GLKP Y + A N G+ + S
Sbjct: 592 TSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
Query: 591 SE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPIRHY 635
S+ KTQ P +++ ++G +SI+V+ D I+ Y
Sbjct: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYIQGY 707
Query: 636 LVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSKAAH 687
+ YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 708 KILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIK 766
Query: 688 FVFRTSAQPTAIP 700
F P+A P
Sbjct: 767 FAKTLEEAPSAPP 779
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 242
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 243 TNMVGERESE 252
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 150 bits (380), Expect = 4e-36
Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632
S S+ KTQ P +++ ++G +SI+V+ D I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668
Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684
+ Y + YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
Query: 685 AAHFVFRTSAQPTAIP 700
F P+A P
Sbjct: 728 EIKFAKTLEEAPSAPP 743
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 150 bits (380), Expect = 4e-36
Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632
S S+ KTQ P +++ ++G +SI+V+ D I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668
Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684
+ Y + YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
Query: 685 AAHFVFRTSAQPTAIP 700
F P+A P
Sbjct: 728 EIKFAKTLEEAPSAPP 743
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 150 bits (380), Expect = 4e-36
Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632
S S+ KTQ P +++ ++G +SI+V+ D I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668
Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684
+ Y + YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
Query: 685 AAHFVFRTSAQPTAIP 700
F P+A P
Sbjct: 728 EIKFAKTLEEAPSAPP 743
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 150 bits (380), Expect = 4e-36
Identities = 195/736 (26%), Positives = 284/736 (38%), Gaps = 88/736 (11%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLT-----PNQQRISVVWNDDSSST 80
PS +S GE C+ G I W+ GE++ P R+ +
Sbjct: 35 PSDLIVSKGEPATLNCKAEG-RPTPTIEWYK-GGERVETDKDDPRSHRMLLPSGSLFFLR 92
Query: 81 LTIYNANIDDAGIYKCVVTGEDGS--ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+ + D G+Y CV G A++ V I + F+ P+ GE AV+
Sbjct: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-DFRQNPSDVMVAVGEPAVME 151
Query: 139 CDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
C P PTI WK G + KD R I + L I +K+D G Y C G + G
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMV-G 208
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
E + ++ V P+ R + N + S C+A G P PT+ W KD ++ +
Sbjct: 209 ERESEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKITYVE- 314
+Y DD + L I+KV D Y C+AEN G E AT+ ++V ++P V+
Sbjct: 267 ----RYEIRDDHT-LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----S 369
+ L VT CEA+G+P P+I WR + L + +S +R S
Sbjct: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRRE-----GSQNLLFSYQPPQSSSRFSVSQTGD 376
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-----QYAPKL--QGPVAVYTWEGNQV 422
LT+ ++Q +D G YIC N G YLEV P + QGPV
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 436
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
++C P TI W +DG +L S+ S IK L++ D G Y C A
Sbjct: 437 VLSCVATGSPVPTILWRKDG-VLVSTQDSRIKQLEN---GVLQIRYAKLGDTGRYTCIAS 492
Query: 483 NRIGQ-------ESLEF-ILVQAD-------TPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
G+ E EF + VQ PS+PS +V S +P G
Sbjct: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEI 587
Y E S W E I GLKP Y + A N G+ +
Sbjct: 553 ATPTSYIIE---AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 588 SAASE-FKTQ---PVQGEPSAPKLEGQMGE-----------DGNSIKVNLIKQDDGGSPI 632
S S+ KTQ P +++ ++G +SI+V+ D I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQYI 668
Query: 633 RHYLVRYRAL-----SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYV--VAENQQGKSK 684
+ Y + YR S+W E+R P+ + V++ L YE+ QG
Sbjct: 669 QGYKILYRPSGANHGESDWLVFEVRTPA-KNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
Query: 685 AAHFVFRTSAQPTAIP 700
F P+A P
Sbjct: 728 EIKFAKTLEEAPSAPP 743
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
P+I + + E TL C+A G P P+I W + +++ H ++ +
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 368 SSLTLKSIQYT--DAGEYICTASNTIGQ---DSQSMYLEVQYAPKLQGPVAVYTWEGNQV 422
L + + + D G Y+C A N +G+ + S+ + + Q P V G
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
Query: 423 NITCE-VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+ C+ +P TISW +DG L + T L +T ++D G Y C
Sbjct: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDER-----ITIRGGKLMITYTRKSDAGKYVCVG 203
Query: 482 VNRIGQESLE 491
N +G+ E
Sbjct: 204 TNMVGERESE 213
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 145 bits (366), Expect = 2e-34
Identities = 113/473 (23%), Positives = 211/473 (44%), Gaps = 35/473 (7%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C++ G + K + W+ E ++ R+S V DS + L ++N +++D+G Y C
Sbjct: 7327 CKIGGSPEIK-VLWYKDETEIQESSKFRMSFV---DSVAVLEMHNLSVEDSGDYTCEAHN 7382
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
GS S +T ++K+ + +F+ P P E +G D + C++ + P + W R+ L
Sbjct: 7383 AAGSASSST-SLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRE--L 7439
Query: 161 KKDVRFIVLSNNYL---QIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQ 215
+ ++ ++S N+L I + D G Y+C+ A ++ + + PP
Sbjct: 7440 RSGKKYKIMSENFLTSIHILNVDAADIGEYQCK----ATNDVGSDTCVGSIALKAPPRFV 7495
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
+ + ++ +G+ V L EG ++ W KD +I +E D+ +S++ + L
Sbjct: 7496 KKLSDISTV--VGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFS 7553
Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP 335
+V+ + +Y C +N AG Q+ L V I + + TL C +G P
Sbjct: 7554 RVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613
Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
S W + ++S+ K + +VS L + ++ +D+G Y N +G+DS
Sbjct: 7614 ELSTKWFKDGKELTSDNK-----YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDS 7668
Query: 396 QSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS 448
+ L+V + KL+ + G+ V + C+V+ P ++SWF +G + S
Sbjct: 7669 CTASLQVSDRTVPPSFTRKLKETNGL---SGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725
Query: 449 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
+ T + L V E+D G+Y C A N G + L + PS
Sbjct: 7726 RKYQTTL--TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPS 7776
Score = 144 bits (362), Expect = 4e-34
Identities = 127/533 (23%), Positives = 226/533 (42%), Gaps = 41/533 (7%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P +++ G++ C VAG + WF E + N+ +IS + S L I N
Sbjct: 7592 PESIKVTTGDTCTLECTVAG-TPELSTKWFKDGKELTSDNKYKISFF---NKVSGLKIIN 7647
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVV 142
D+G+Y V G +S T ++++ + + F G V+ C V
Sbjct: 7648 VAPSDSGVYSFEVQNPVGKDS-CTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY 7706
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINF 201
S P ++ W H+G ++ + + + N L + ++++D G Y C +A +
Sbjct: 7707 GSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDEC- 7765
Query: 202 KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+ V PP+ + + ++ G +VT +G P ++SW K ++ D
Sbjct: 7766 -SAPLTVREPPSFVQKPDPMDVLT--GTNVTFTSIVKGTPPFSVSWFKGSSELVPG-DRC 7821
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321
D ++L + VD + EY CI N+AG+ T HL + A K N ++E
Sbjct: 7822 NVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYSIEK 7881
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
+ + L +G P S+TW+ + N++ ++ + + + + L + S DAG
Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQR-----CNITTTEKSAILEIPSSTVEDAG 7936
Query: 382 EYICTASNTIGQDS---QSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
+Y C N G+DS Q + LE Y K PV V G+ ++ C++ P +SW
Sbjct: 7937 QYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSV--GDSASLQCQLAGTPEIGVSW 7994
Query: 439 FR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
++ D +L P++ Y K++ + + L ND G Y C A N +G+ S L
Sbjct: 7995 YKGDTKLRPTTTY---KMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051
Query: 498 DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
+ PS + Q + + T G+P++ + G E WY
Sbjct: 8052 EQKLPPSFSR----------QLRDVQETVGLPVV---FDCAISGSEPISVSWY 8091
Score = 134 bits (337), Expect = 4e-31
Identities = 131/551 (23%), Positives = 221/551 (40%), Gaps = 52/551 (9%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G+S F CQ+ G K + +SW+ E + IS + D +T I A ++++G
Sbjct: 4876 GQSTTFECQITGTPKIR-VSWYLDGNEITAIQKHGISFI---DGLATFQISGARVENSGT 4931
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C + G+ S ++ +K+ + F P E + D + C+V + P + W
Sbjct: 4932 YVCEARNDAGTAS-CSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLK 4990
Query: 154 KGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPP 212
R++ K + + L I +D G Y+C + G +V + PP
Sbjct: 4991 NNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCI--VSNEGGSCSCSTRVALKEPP 5048
Query: 213 TIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQ 271
+ + I N T L S T G P +++W KD + ++ EDD YI F D +
Sbjct: 5049 SFIKK--IENTTTVLKSSATFQSTVAGSPPISITWLKDDQILD--EDDNVYISFVDSVAT 5104
Query: 272 LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA 331
L I+ VD Y C A+N++G + L V +I + ++ +TL C
Sbjct: 5105 LQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVV 5164
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391
+G P + W + I + + V+S ++S+ D+G+Y N
Sbjct: 5165 AGTPELKVKWLKDGKQIVPSR-----YFSMSFENNVASFRIQSVMKQDSGQYTFKVENDF 5219
Query: 392 GQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
G S YL V + KL V G+ +++ C+V + WF+DG+
Sbjct: 5220 GSSSCDAYLRVLDQNIPPSFTKKLTKMDKVL---GSSIHMECKVSGSLPISAQWFKDGKE 5276
Query: 445 LPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS--- 501
+ +S + ++ + LEV D NY C N G ++ IL + PS
Sbjct: 5277 ISTS--AKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLV 5334
Query: 502 SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561
P Q P S+ V+F ILK G + KW+ + G
Sbjct: 5335 KPGRQQAIPDST---VEFK--------AILK--------GTPPFKIKWFKDDVELVSGPK 5375
Query: 562 TIVGLKPETTY 572
+GL+ T++
Sbjct: 5376 CFIGLEGSTSF 5386
Score = 129 bits (325), Expect = 9e-30
Identities = 133/584 (22%), Positives = 234/584 (40%), Gaps = 32/584 (5%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
D+ P ++++GES F C V G A K I+W N E ++++V ++++TLT
Sbjct: 7215 DLKPVSVDLALGESGTFKCHVTGTAPIK-ITWAKDNREIRPGGNYKMTLV---ENTATLT 7270
Query: 83 IYNANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
+ DAG Y C + G +S A + V+ + + K P+ + ++ E C +
Sbjct: 7271 VLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS-RIVKQDEFTRYECKI 7329
Query: 142 VSSLPPTIIWKHKGRDVILKKDVRF-IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
S ++W ++ R V S L++ + D G Y CE A +
Sbjct: 7330 GGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASS 7389
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
++ V PP + + + + G V L C+ +G P +SW KD ++
Sbjct: 7390 STSLK--VKEPPIFRKKPHPIETLK--GADVHLECELQGTPPFHVSWYKDKREL---RSG 7442
Query: 261 EKYIFSDDS--SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+KY ++ + + I VD D EY C A N G + + A P+ + +
Sbjct: 7443 KKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDIS 7502
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+ ++V L G S+ W I E ++ + +++L ++
Sbjct: 7503 TVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRE----SDNIWISYSENIATLQFSRVEPA 7558
Query: 379 DAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
+AG+Y C N G L V + A ++ P ++ G+ + C V P +
Sbjct: 7559 NAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTK 7618
Query: 438 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
WF+DG+ L S N I +N S L++ + +D G Y+ N +G++S L +
Sbjct: 7619 WFKDGKELTSDNKYKISFFN--KVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVS 7676
Query: 498 DTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D PS + + S ++ V E + G PI W G E+ + Y
Sbjct: 7677 DRTVPPSFTRKLKETNGLSGSSVVM--ECKVYGSPPI---SVSWFHEGNEISSGRKYQTT 7731
Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+T+ L+ + A N G E SA + P
Sbjct: 7732 LTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPP 7775
Score = 129 bits (323), Expect = 1e-29
Identities = 111/481 (23%), Positives = 209/481 (43%), Gaps = 37/481 (7%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GES C+++G + K +SWF + E + +S + +S + LTI A+ +D+G
Sbjct: 6379 GESIQLECKISGSPEIK-VSWFRNDSELHESWKYNMSFI---NSVALLTINEASAEDSGD 6434
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G S +T + + +F P+P +G D ++ C++ + P ++W
Sbjct: 6435 YICEAHNGVGDASCSTA-LTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493
Query: 154 KGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
+ V + +F + S ++ L I ++ +D G Y C+ A E+ V
Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCK----ATNEVGSDTCSCSVKF 6547
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
+ + + + + +G +V L EGF ++ W KD ++ +E ++ + F D+ +
Sbjct: 6548 KEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIA 6607
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L + + ++ +YIC +N AG ++ + L V +I + L C
Sbjct: 6608 TLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECV 6667
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
+G P S W R +S++ K H + + +V+SL + + +D G Y N+
Sbjct: 6668 VTGTPELSAKWFKDGRELSADSK----HHITFIN-KVASLKIPCAEMSDKGLYSFEVKNS 6722
Query: 391 IGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
+G+ + ++ + V + KL+ A+ G V + C V ++ WF+DG
Sbjct: 6723 VGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL---GASVVLECRVSGSAPISVGWFQDGN 6779
Query: 444 LL---PSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
+ P S + T + S LE +D G Y C A N G + +L + P
Sbjct: 6780 EIVSGPKCQSSFSENVCTLNLSLLE-----PSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834
Query: 501 S 501
S
Sbjct: 6835 S 6835
Score = 127 bits (319), Expect = 4e-29
Identities = 120/532 (22%), Positives = 200/532 (37%), Gaps = 39/532 (7%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I WF + E ++ + I + + S+S L +Y+ + G Y C VT + GS+S T+
Sbjct: 5361 IKWFKDDVELVSGPKCFIGL---EGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL-S 170
+ K + + G+ + + C + S ++W ++ R + S
Sbjct: 5418 LVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDS 5477
Query: 171 NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQS 230
+Q+ + D G + CE + A +VIV PP + IV N
Sbjct: 5478 VAVIQMNNLSTEDSGDFICEAQNPAGS--TSCSTKVIVKEPPVFSSFPPIVETLKN--AE 5533
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
V+L C+ G P + W KD Q+ + K + + + I VD +D EY C A+
Sbjct: 5534 VSLECELSGTPPFEVVWYKDKRQLRSSK-KYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISS 350
N+ G +K+ P+ N + E L G + W +
Sbjct: 5593 NEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652
Query: 351 EEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS---MYLEVQYAPK 407
E + + V V++L + +AG+YIC N G M LE +
Sbjct: 5653 ESENIRITFV----ENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVE 5708
Query: 408 LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
GP+ V G + C+V P ++ W++DG+LL SS YN S L +
Sbjct: 5709 KAGPMTVTV--GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN--KISSLRIL 5764
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGG 527
D G Y N +G+ S ++ +D PS + + TGG
Sbjct: 5765 SVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTR-------------RLKNTGG 5811
Query: 528 VPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
V E + G W+ K + G K +TT++ + L
Sbjct: 5812 VLGASCILECKVAGSSPISVAWFHEKTK------IVSGAKYQTTFSDNVCTL 5857
Score = 127 bits (319), Expect = 4e-29
Identities = 103/483 (21%), Positives = 208/483 (43%), Gaps = 35/483 (7%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ G+S C++AG + + + WF E ++ R++ + DS + + + N + +D
Sbjct: 5435 VKAGDSSRLECKIAGSPEIR-VVWFRNEHELPASDKYRMTFI---DSVAVIQMNNLSTED 5490
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
+G + C GS S +T V + + +F + P E + + + C++ + P ++
Sbjct: 5491 SGDFICEAQNPAGSTSCST-KVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549
Query: 151 WKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
W R L+ ++ + S N+ + I + +D G Y C+ A+ E+
Sbjct: 5550 WYKDKRQ--LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCK----AQNEVGSDTCVCT 5603
Query: 208 VNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF 265
V + PP ++ N + A G+ L EG + W K+ E++ +E ++ + F
Sbjct: 5604 VKLKEPPRFVSKLNSLTVVA--GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITF 5661
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
++ + L K + + +YIC +N G ++ L V I + + E
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETC 5721
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
TL C+ +G P S+ W + ++S +K + ++SSL + S++ DAG Y
Sbjct: 5722 TLECKVAGTPELSVEWYKDGKLLTSSQK-----HKFSFYNKISSLRILSVERQDAGTYTF 5776
Query: 386 TASNTIGQDSQSMYLEV-------QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
N +G+ S + ++V + +L+ V G + C+V +++W
Sbjct: 5777 QVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVL---GASCILECKVAGSSPISVAW 5833
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
F + + S + + + + L++ +D GNY C A N G + +L +
Sbjct: 5834 FHEKTKIVSG--AKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Query: 499 TPS 501
PS
Sbjct: 5892 PPS 5894
Score = 126 bits (316), Expect = 1e-28
Identities = 119/475 (25%), Positives = 200/475 (42%), Gaps = 26/475 (5%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
GES C++ G + ++WF N E N R+ V +S + L I + ++D+G
Sbjct: 3752 GESARLHCKLKGSPVIQ-VTWFKNNKELSESNTVRMYFV---NSEAILDITDVKVEDSGS 3807
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C + GS+S +T + I + F P + G +A++ C+V + P I W
Sbjct: 3808 YSCEAVNDVGSDSCST-EIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFK 3866
Query: 154 KGRDVILKKDVR-FIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV--IVNV 210
+ + K R F S L+I D G Y C + E+ ++
Sbjct: 3867 DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC----VVANEVGKCGCMATHLLKE 3922
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPT + + + A GQ+VTL G +++W K G+++ +E+ K FS+ +
Sbjct: 3923 PPTFVKKVDDLIALG--GQTVTLQAAVRGSEPISVTWMK-GQEVIREDGKIKMSFSNGVA 3979
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L I V + +Y C+AEN+AG Q + L V KI + + TL
Sbjct: 3980 VLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYT 4039
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
+G P W R + + +K + V+ L S + D+G+Y SN
Sbjct: 4040 VAGTPELKPKWYKDGRPLVASKK-----YRISFKNNVAQLKFYSAELHDSGQYTFEISNE 4094
Query: 391 IGQDS---QSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
+G S L+ AP P+ V + + C++ +SWF+DG+ +
Sbjct: 4095 VGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIA 4154
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
+S+ +I + LE+ ND GN+ C A N +G + L+ + PS
Sbjct: 4155 ASD--RYRIAFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPS 4207
Score = 124 bits (310), Expect = 5e-28
Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 26/469 (5%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E +VG+S CQVAG + +SW+ KL P + + N + +TL NI+
Sbjct: 6089 EAAVGDSVSLQCQVAG-TPEITVSWYK-GDTKLRPTPEYRTYFTN--NVATLVFNKVNIN 6144
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM---FKNAPTPQEFREGEDAVIVCDVVSSLP 146
D+G Y C G+ S TV +I ++ + F E G + C + S P
Sbjct: 6145 DSGEYTCKAENSIGTASSKTV-FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAP 6203
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD---EGTYRCE-GRILARGEINFK 202
+ W G V+L+ D + + I +TD G Y C L + +
Sbjct: 6204 IQVCWYRDG--VLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSAR 6261
Query: 203 DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEK 262
P + ++ A G+S C G ++W+KD ++I + +
Sbjct: 6262 LTAREPKKSPFFDIKPVSIDVIA--GESADFECHVTGAQPMRITWSKDNKEI-RPGGNYT 6318
Query: 263 YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK-ITYVENQTAMEL 321
++ L I KV K D +Y C A N G+ + L V PK + +E +
Sbjct: 6319 ITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQ 6378
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
E + L C+ SG P ++W RN S ++ +M + V+ LT+ D+G
Sbjct: 6379 GESIQLECKISGSPEIKVSW---FRNDSELHESWKYNMSFIN--SVALLTINEASAEDSG 6433
Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440
+YIC A N +G S S L V+ P Q P V +G+ V + CE+ P + W +
Sbjct: 6434 DYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVK 6493
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
D + + N KI + + L + +D G Y+C A N +G ++
Sbjct: 6494 DRKQV--RNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDT 6540
Score = 120 bits (301), Expect = 5e-27
Identities = 127/548 (23%), Positives = 216/548 (39%), Gaps = 41/548 (7%)
Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
+G S C+V+G A + WF E ++ + + S ++ TL + D G
Sbjct: 6754 LGASVVLECRVSGSAPIS-VGWFQDGNEIVSGPKCQSSF---SENVCTLNLSLLEPSDTG 6809
Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWK 152
IY CV GS+ E + + + + F+ P E G V+ PP +
Sbjct: 6810 IYTCVAANVAGSD-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFT-SVIRGTPPFKVKW 6867
Query: 153 HKGRDVILKKDVRFIVLSN--NYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIV 208
KG ++ + I L + L++ ++ + G Y C L + + V
Sbjct: 6868 FKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSC----LVTNDAGSASCTTHLFV 6923
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P T R + + + G + L G P ++SW KD I Q E ++
Sbjct: 6924 KEPATFVKR--LADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCS-ITMTEK 6980
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
S+ L I + D A+Y C+ EN+AG+ + V P + E TL
Sbjct: 6981 STILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQ 7040
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
C+ G P I+W + S ++ V+SL + + ++D GEY C A
Sbjct: 7041 CKVDGTPEIRISWYKEHTKLRSAPA-----YKMQFKNNVASLVINKVDHSDVGEYSCKAD 7095
Query: 389 NTIGQDSQSMYLEVQ-------YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
N++G + S L ++ +A KL+ V+ G V C + +SW++D
Sbjct: 7096 NSVGAVASSAVLVIKARKLPPFFARKLKD---VHETLGFPVAFECRINGSEPLQVSWYKD 7152
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADT 499
G LL +N++ + + L++ ++ G YNC+A N +G S + IL + +
Sbjct: 7153 GVLLKDD--ANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEV 7210
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + V + + + TG PI K W E+ Y K +E
Sbjct: 7211 PPFFDLKPVSVDLALGESGTFKCHVTGTAPI---KITWAKDNREIRPGGNY--KMTLVEN 7265
Query: 560 IVTIVGLK 567
T+ LK
Sbjct: 7266 TATLTVLK 7273
Score = 119 bits (298), Expect = 1e-26
Identities = 121/537 (22%), Positives = 204/537 (37%), Gaps = 38/537 (7%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
+ + L I N+ DAG Y C + E G + + V + F P E G+
Sbjct: 6038 EKTCILEILNSTKRDAGQYSCEIENEAGRDVCGAL-VSTLEPPYFVTELEPLEAAVGDSV 6096
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRI 193
+ C V + T+ W +KG + +NN L + D G Y C+
Sbjct: 6097 SLQCQVAGTPEITVSW-YKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK--- 6152
Query: 194 LARGEINFKDIQVIVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
A I + + + PP+ + + T +G VTL C G + W
Sbjct: 6153 -AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT--VGLPVTLTCRLNGSAPIQVCWY 6209
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+DG + +E+ + F D+ + L I + D + +Y C A N G ++ L
Sbjct: 6210 RDGVLLRDDENLQTS-FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPK 6268
Query: 309 KITYVENQTA---MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
K + + + + E C +G ITW + I G+ +
Sbjct: 6269 KSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRP-----GGNYTITCVG 6323
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVAVYTWEGNQVN 423
L + + D+G+Y C A+N +G+D S L V+ PK + + +G +
Sbjct: 6324 NTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQ 6383
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483
+ C++ P +SWFR+ L S N+ N S + L + S D G+Y C A N
Sbjct: 6384 LECKISGSPEIKVSWFRNDSELHESWKYNMSFIN--SVALLTINEASAEDSGDYICEAHN 6441
Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD---EPEATGGVPILKYKAEWRAV 540
+G S L T +P + +P A D + E +G P ++ W
Sbjct: 6442 GVGDASCSTAL----TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPP---FEVVWVKD 6494
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
++V +SK + + + I+ L+ A N G S + +FK P
Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPP 6551
Score = 117 bits (292), Expect = 6e-26
Identities = 123/517 (23%), Positives = 201/517 (38%), Gaps = 33/517 (6%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+++G ++ W+ + + + +I+ + + +++ I N + D G Y C
Sbjct: 5538 CELSG-TPPFEVVWYKDKRQLRSSKKYKIA---SKNFHTSIHILNVDTSDIGEYHCKAQN 5593
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
E GS++ VK+ + F + GE A + + + P + W + +VI
Sbjct: 5594 EVGSDT-CVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIR 5652
Query: 161 KKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
+ + I N LQ + + G Y C+ I G + ++V P I +
Sbjct: 5653 ESENIRITFVENVATLQFAKAEPANAGKYICQ--IKNDGGMRENMATLMVLEPAVIVEKA 5710
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ T +G++ TL C G PE ++ W KDG+ + + K+ F + S L I V+
Sbjct: 5711 GPMTVT--VGETCTLECKVAGTPELSVEWYKDGKLLTSSQK-HKFSFYNKISSLRILSVE 5767
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAK---PKITYVENQTAMELEEQVTLTCEASGDP 335
+ D Y +N G+ T + V + P T T L L C+ +G
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827
Query: 336 IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
S+ W I S K V +L L S+ +D G Y C A+N G D
Sbjct: 5828 PISVAWFHEKTKIVSGAK-----YQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDE 5882
Query: 396 QSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
L VQ P ++ P + G V T + P ++WFR + L + NI
Sbjct: 5883 CRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNI- 5941
Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE---FILVQADTPSSPSIDQVEPY 511
Y + + LE+ + G Y C N GQ S F+ A S VEP
Sbjct: 5942 -YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPG 6000
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548
S E TG +PI W+ G + S+
Sbjct: 6001 KSIIL----ESTYTGTLPI---SVTWKKDGFNITTSE 6030
Score = 114 bits (285), Expect = 4e-25
Identities = 136/583 (23%), Positives = 223/583 (38%), Gaps = 30/583 (5%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
DI P ++ GES F C V G A+ I+W N E I+ V N + L
Sbjct: 6274 DIKPVSIDVIAGESADFECHVTG-AQPMRITWSKDNKEIRPGGNYTITCVGN---TPHLR 6329
Query: 83 IYNANIDDAGIYKCVVTGEDGSE-SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
I D+G Y C T + G + A ++VK K + K + ++GE + C +
Sbjct: 6330 ILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFV-KKLEASKVAKQGESIQLECKI 6388
Query: 142 VSSLPPTIIWKHKGRDV--ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
S + W ++ K ++ FI S L I D G Y CE G+
Sbjct: 6389 SGSPEIKVSWFRNDSELHESWKYNMSFI-NSVALLTINEASAEDSGDYICEAH-NGVGDA 6446
Query: 200 NFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
+ + V PP + + V A G V L C+ G P + W KD +Q+ +
Sbjct: 6447 SC-STALTVKAPPVFTQKPSPVGALK--GSDVILQCEISGTPPFEVVWVKDRKQVRNSK- 6502
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
K + L I ++ +D EY C A N+ G + +K P+ + T+
Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTST 6562
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ + V L G S+ W + E + + +++L L S + ++
Sbjct: 6563 LIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFI----DNIATLQLGSPEASN 6618
Query: 380 AGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
+G+YIC N G S L V + A ++ P + GN + C V P + W
Sbjct: 6619 SGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPELSAKW 6678
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
F+DG+ L + + +I N + L++ +D G Y+ N +G+ + + +D
Sbjct: 6679 FKDGRELSADSKHHITFIN--KVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSD 6736
Query: 499 TPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
PS + V + V E +G PI W G E+ +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVL--ECRVSGSAPI---SVGWFQDGNEIVSGPKCQSSF 6791
Query: 555 ASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+ + + L+P T A N G E SA + P
Sbjct: 6792 SENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPP 6834
Score = 112 bits (279), Expect = 2e-24
Identities = 124/562 (22%), Positives = 218/562 (38%), Gaps = 44/562 (7%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C++AG + +SWF E ++ RI+ V + +++L I +++DAG + C T
Sbjct: 4134 CKIAGSLPMR-VSWFKDGKEIAASDRYRIAFV---EGTASLEIIRVDMNDAGNFTCRATN 4189
Query: 101 EDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVIL 160
GS+ + + + + F P ++ G + S P TI W KG ++
Sbjct: 4190 SVGSKDSSGALI-VQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW-FKGNKELV 4247
Query: 161 KKDVRFIVLS--NNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQ 218
+I + L++ +K +D GTY C+ +A G ++ V P T +
Sbjct: 4248 SGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANL--FVKEPATFVEKL 4305
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ G + L C G P ++W + +I+ E + F + ++ L + V
Sbjct: 4306 E-PSQLLKKGDATQLACKVTGTPPIKITWFANDREIK-ESSKHRMSFVESTAVLRLTDVG 4363
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
D EY+C A+N+AG + + V P T + E V L E +G P
Sbjct: 4364 IEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFE 4423
Query: 339 ITW---RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDS 395
ITW T R+ + + H+V SL + DAGEY C +N +G
Sbjct: 4424 ITWFKDNTILRSGRKYKTFIQDHLV--------SLQILKFVAADAGEYQCRVTNEVGSSI 4475
Query: 396 QSMYLEVQYAPKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
S + ++ P + + + G + T++W +D + + +
Sbjct: 4476 CSARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMT 4535
Query: 455 IYNTPSASYL---EVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD----TPSSPSIDQ 507
N ++ YL EV D G Y C A N G + +L + T + SID
Sbjct: 4536 FENNVASLYLSGIEVKHD-----GKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDV 4590
Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567
+ +T QV+F + + A+W G+E+ Y I+ I+ +
Sbjct: 4591 TQGDPATLQVKFSGTK--------EITAKWFKDGQELTLGSKYKISVTDTVSILKIISTE 4642
Query: 568 PETTYAVRLAALNGKGLGEISA 589
+ + N G A
Sbjct: 4643 KKDSGEYTFEVQNDVGRSSCKA 4664
Score = 111 bits (277), Expect = 3e-24
Identities = 159/648 (24%), Positives = 254/648 (39%), Gaps = 81/648 (12%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
++SVG+S CQ+AG + +SW+ + KL P N+ +TL +I+
Sbjct: 7971 KVSVGDSASLQCQLAG-TPEIGVSWYKGD-TKLRPTTTYKMHFRNN--VATLVFNQVDIN 8026
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE--GEDAVIVCDVVSSLPP 147
D+G Y C G S +T QKL + ++ +E G V C + S P
Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086
Query: 148 TIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDE---GTYRCEG-RILARGEINFKD 203
++ W G+ + +V+ L N I KTD G Y C + + +
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNT--ATLNIFKTDRSLAGQYSCTATNPIGSASSSARL 8144
Query: 204 IQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
I PP R V+A +G+S C G +SW KD +I KY
Sbjct: 8145 ILTEGKNPPFFDIRLAPVDAV--VGESADFECHVTGTQPIKVSWAKDSREIRS---GGKY 8199
Query: 264 IFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKV---FAKPKITYVENQTA 318
S ++S+ LT+ KVDK D +Y C A N+ G+ T L + P T ++T
Sbjct: 8200 QISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETV 8259
Query: 319 MELE-EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E E L +G ++ W + I + T + + +++ V L ++
Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKNNIEI---QPTSNCEITFKNNTLV--LQVRKAGM 8314
Query: 378 TDAGEYICTASNTIGQD--SQSMYLEVQYAPKL--QGPVAVYTWEGNQVNITCEVFAYPS 433
DAG Y C SN G + S+ ++ P + Q V EG V ++C V
Sbjct: 8315 NDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEP 8374
Query: 434 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I W + G+ + S+ + + LE+ ++ D G+Y C A N G ++ +
Sbjct: 8375 IRIQWLKAGREIKPSDRCSFSF--ASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSK 8432
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQ-----FDEPEA--------------TGGVPI--LK 532
+ D P+ V P + A V EP++ GG PI +K
Sbjct: 8433 VTIKDKPA------VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVK 8486
Query: 533 Y-KAEWRAV---GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-- 586
+ K +WR + G H K +AK + T GL R A N G E
Sbjct: 8487 WTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGL-------YRCVAFNEHGEIESN 8539
Query: 587 --ISAASEFKTQPVQGEPSA-----PKLEGQMGEDGNSIKVNLIKQDD 627
+ K + ++G+ A P L+ GE+ + L+K D
Sbjct: 8540 VNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVD 8587
Score = 105 bits (263), Expect = 1e-22
Identities = 121/557 (21%), Positives = 208/557 (37%), Gaps = 36/557 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSES-EATV 110
++W + E + R++ +++ ++L + + G Y C + G + A +
Sbjct: 4517 VTWLKDSDEITEDDNIRMTF---ENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALL 4573
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+VK + + +G+ A + + T W G+++ L + V
Sbjct: 4574 SVK--EPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTD 4631
Query: 171 N-NYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNAT 224
+ L+I +K D G Y E GR + IN D+ + PP+ + +++
Sbjct: 4632 TVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLII----PPSFTKKLKKMDSI 4687
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
G + L C G ++ W KD ++I E K+ F D+++ L I +++ D
Sbjct: 4688 K--GSFIDLECIVAGSHPISIQWFKDDQEISASEK-YKFSFHDNTAFLEISQLEGTDSGT 4744
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Y C A NKAG + HL V P + +V L G +I W
Sbjct: 4745 YTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKD 4804
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
+ + S V +SL L + + TD+G YIC SN +G + L V+
Sbjct: 4805 NKELHS-----GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKE 4859
Query: 405 AP---KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461
P K PV V G C++ P +SW+ DG + + I +
Sbjct: 4860 PPQFIKKPSPVLVLR-NGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFID--GL 4916
Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFD- 520
+ +++ + G Y C A N G S L + P+ I +++P +
Sbjct: 4917 ATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPT--FIRELKPVEVVKYSDVEL 4974
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
E E TG P ++ W E+ SK Y + + I P T + N
Sbjct: 4975 ECEVTGTPP---FEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSN 5031
Query: 581 GKGLGEISAASEFKTQP 597
G S K P
Sbjct: 5032 EGGSCSCSTRVALKEPP 5048
Score = 102 bits (255), Expect = 1e-21
Identities = 102/449 (22%), Positives = 181/449 (40%), Gaps = 34/449 (7%)
Query: 52 ISWFSPNGEKLTPNQQ-RISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATV 110
+ W E + ++ RI+ V N +TL A +AG Y C + DG E
Sbjct: 5641 VQWLKEKEEVIRESENIRITFVEN---VATLQFAKAEPANAGKYICQIKN-DGGMRENMA 5696
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+ + + + P GE + C V + ++ W G+ + + +F +
Sbjct: 5697 TLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYN 5756
Query: 171 N-NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV-----PPTIQARQNIVNAT 224
+ L+I +++ D GTY + + + +V+V PP+ R + N
Sbjct: 5757 KISSLRILSVERQDAGTYTFQ----VQNNVGKSSCTAVVDVSDRAVPPSFTRR--LKNTG 5810
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDE 282
LG S L C G +++W + +I KY FSD+ L + +D +D
Sbjct: 5811 GVLGASCILECKVAGSSPISVAWFHEKTKIVS---GAKYQTTFSDNVCTLQLNSLDSSDM 5867
Query: 283 AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSIT 340
Y C+A N AG + L V P ++V+ +E+ + VT T G P +
Sbjct: 5868 GNYTCVAANVAGSDECRAVLTVQEPP--SFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
W R + ++ + V+ L L +I + +GEY C SN GQ S + L
Sbjct: 5926 WFRGARELVKGDR-----CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRL 5980
Query: 401 EVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
V+ ++ ++ E G + + +++W +DG + +S N I T
Sbjct: 5981 FVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCN--IVTTE 6038
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQE 488
LE+ ++ D G Y+C N G++
Sbjct: 6039 KTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 102 bits (253), Expect = 2e-21
Identities = 118/461 (25%), Positives = 182/461 (39%), Gaps = 31/461 (6%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE-SEATV 110
+SW E L +R S+ + S+ L I + I+D Y C++ E G + EA V
Sbjct: 6958 VSWIKD--EYLISQSERCSITMTE-KSTILEILESTIEDYAQYSCLIENEAGQDICEALV 7014
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+V + F E GE A + C V + I W +K + +
Sbjct: 7015 SV--LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISW-YKEHTKLRSAPAYKMQFK 7071
Query: 171 NNY--LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIV--NVPPTIQARQNIVNATAN 226
NN L I + +D G Y C+ G + + VI +PP + V+ T
Sbjct: 7072 NNVASLVINKVDHSDVGEYSCKADNSV-GAVASSAVLVIKARKLPPFFARKLKDVHET-- 7128
Query: 227 LGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
LG V C G +SW KDG ++ + + + F + + L I + D++ +Y
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTS-FVHNVATLQILQTDQSHIGQYN 7187
Query: 287 CIAENKAGEQDATIHLKVF---AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRT 343
C A N G ++ L + P + L E T C +G ITW
Sbjct: 7188 CSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAK 7247
Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
R I G+ + ++LT+ + DAG+Y C ASN G+DS S L VQ
Sbjct: 7248 DNREIRP-----GGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ 7302
Query: 404 YAP----KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTP 459
P KL+ V E + C++ P + W++D + S S ++
Sbjct: 7303 EPPRFIKKLEPSRIVKQDEFTRYE--CKIGGSPEIKVLWYKDETEIQES--SKFRMSFVD 7358
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
S + LE+ S D G+Y C A N G S L + P
Sbjct: 7359 SVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPP 7399
Score = 99.8 bits (247), Expect = 1e-20
Identities = 152/620 (24%), Positives = 234/620 (37%), Gaps = 89/620 (14%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E+ V E + + + + D D W+ E Q+R V + + I
Sbjct: 3155 EVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVV-ERRIHRMFISETRQS 3213
Query: 90 DAGIYKCVVTGEDGSESEATVNV----KIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSL 145
DAG Y V G + S VN ++ Q+L P + G+ A C V+S
Sbjct: 3214 DAGEYT-FVAGRNRSSVTLYVNAPEPPQVLQELQ------PVTVQSGKPARF-CAVISGR 3265
Query: 146 P-PTIIWKHKGRDVILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGR---------- 192
P P I W + + + +F+ Y L I + D Y CE +
Sbjct: 3266 PQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE-DAAVYTCEAKNDYGVATTSA 3324
Query: 193 --ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+ E+ D ++ V P I Q+ V + GQ C G + +SW
Sbjct: 3325 SLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSE---GQPARFQCRVSG-TDLKVSWYSK 3380
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
++I+ F +D+ QL I + DE Y +A N G+ +T +L + A I
Sbjct: 3381 DKKIKPSRFFRMTQF-EDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESI 3439
Query: 311 TY--VENQTAMELEEQVTL-----------------TCEASGDPIPSITWRTSTRNISSE 351
+ +E + ME++ + TCE P W + R I
Sbjct: 3440 LHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYES 3499
Query: 352 EKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV--QYAPK-L 408
+K +RS +SSL + Q D GEY C ASN G S + L V Y P L
Sbjct: 3500 DKCS-----IRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFL 3554
Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL-PSSNYSNIKIYNTPSASYLEVT 467
P ++ T+ G C V P W +DG L PS N+ +I + + LE++
Sbjct: 3555 SRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW---RISDAENKHILELS 3611
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST------AQVQFDE 521
+ D G Y+C A N+ G + + L+ D P I ++EP S + Q DE
Sbjct: 3612 NLTIQDRGVYSCKASNKFGADICQAELIIIDKPH--FIKELEPVQSAINKKVHLECQVDE 3669
Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWY----DAKEASMEGIVTIVGLKPETTYAVRLA 577
K W G+++ K Y + K A++E + + LK TY
Sbjct: 3670 DR--------KVTVTWSKDGQKLPPGKDYKICFEDKIATLE--IPLAKLKDSGTYV--CT 3717
Query: 578 ALNGKGLGEISAASEFKTQP 597
A N G SA + P
Sbjct: 3718 ASNEAGSSSCSATVTVREPP 3737
Score = 98.2 bits (243), Expect = 3e-20
Identities = 131/599 (21%), Positives = 224/599 (37%), Gaps = 68/599 (11%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C V ISW+ E+L + + +D TL + A +DA +Y C
Sbjct: 3259 CAVISGRPQPKISWYKE--EQLLSTGFKCKFL-HDGQEYTLLLIEAFPEDAAVYTCEAKN 3315
Query: 101 EDG-SESEATVNVKIFQKLM-FKNAP-------TPQE---FREGEDAVIVCDVVSSLPPT 148
+ G + + A+++V++ + + + P TP + EG+ A C V S
Sbjct: 3316 DYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRV-SGTDLK 3374
Query: 149 IIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTY-----RCEGRILARGEINFK 202
+ W K + + + R + Y L+I DEGTY G++ + ++ +
Sbjct: 3375 VSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLE 3434
Query: 203 ------------DIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
+I++ + P I ++ I LG C+ + P W K
Sbjct: 3435 APESILHERIEQEIEMEMKAAPVI--KRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKA 3492
Query: 251 GEQIEQEED----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
G +I + + KYI S L I + D EY C A N+ G T L V
Sbjct: 3493 GREIYESDKCSIRSSKYI-----SSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE 3547
Query: 307 KPKITYVENQTAME--LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
T++ ++ + + C +G P+ W+ +S +
Sbjct: 3548 AYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHI 3607
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVAVYTWEGNQVN 423
+S+LT++ D G Y C ASN G D Q+ + + ++ V + +V+
Sbjct: 3608 LELSNLTIQ-----DRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVH 3662
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVN 483
+ C+V T++W +DGQ LP + KI + LE+ D G Y CTA N
Sbjct: 3663 LECQVDEDRKVTVTWSKDGQKLPPGK--DYKICFEDKIATLEIPLAKLKDSGTYVCTASN 3720
Query: 484 RIGQESLEFILVQADTPS-----SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
G S + + PS PS + S+ + G P++ + W
Sbjct: 3721 EAGSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHCKLK------GSPVI--QVTWF 3772
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+E+ S + E I+ I +K E + + A+N G S K P
Sbjct: 3773 KNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP 3831
Score = 94.7 bits (234), Expect = 3e-19
Identities = 152/686 (22%), Positives = 268/686 (39%), Gaps = 74/686 (10%)
Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
F C+V + + WF N E + + + I + D TL I +A++DD Y +
Sbjct: 12659 FNCEV--NTEGAKAKWFR-NEEAIFDSSKYI--ILQKDLVYTLRIRDAHLDDQANYNVSL 12713
Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQ-EFREGEDAVIVCDVVSSLPPTIIWKHKGRD 157
T G ++ N+ + ++ + P E E + C V + L T+ W G +
Sbjct: 12714 TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEE 12772
Query: 158 VILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA 216
V V + V + L I+ DEG Y I+ G+ K + ++ + +
Sbjct: 12773 VPFDNRVSYRVDKYKHMLTIKDCGFPDEGEY-----IVTAGQD--KSVAELLIIEAPTEF 12825
Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS--QLTI 274
+++ + T C + + W ++G +I++ +KY F D S +L I
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSR-EKANVKWYRNGREIKE---GKKYKFEKDGSIHRLII 12881
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE---QVTLTCEA 331
K +DE EY C G +D ++F + + LE V E
Sbjct: 12882 KDCRLDDECEYAC------GVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAEL 12935
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI 391
+ D + + W + + +K H ++ S ++ L + I+ D GEY I
Sbjct: 12936 NKDKV-EVQWLRNNMVVVQGDK----HQMM-SEGKIHRLQICDIKPRDQGEY-----RFI 12984
Query: 392 GQDSQSMY-LEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSN 449
+D ++ LE+ APK++ + G + + AYP A WF++ + L +
Sbjct: 12985 AKDKEARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKT 13044
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP-SIDQV 508
I T + + + D G Y N+ G+ L D P +++
Sbjct: 13045 -----IDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVT 13099
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL-K 567
E + + ++EP GG I+ Y E R ++ W A + + T+ GL K
Sbjct: 13100 ETFDGEVSLAWEEPLTDGGSKIIGYVVERR----DIKRKTWVLATDRAESCEFTVTGLQK 13155
Query: 568 PETTYAVRLAALNGKGLGE-------ISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV 620
Y R++A N G GE + A S++ V G P + D N V
Sbjct: 13156 GGVEYLFRVSARNRVGTGEPVETDNPVEARSKY---DVPGPPLNVTI-----TDVNRFGV 13207
Query: 621 NLI---KQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 676
+L + DGG+ I +Y++ R +S W + + + + + EY V A
Sbjct: 13208 SLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRA 13267
Query: 677 ENQQGKSK-AAHFVFRTSAQPTAIPA 701
+N+ G K +A F A P P+
Sbjct: 13268 QNRIGVGKPSAATPFVKVADPIERPS 13293
Score = 84.7 bits (208), Expect = 3e-16
Identities = 70/266 (26%), Positives = 112/266 (42%), Gaps = 41/266 (15%)
Query: 174 LQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVN-----VPPTIQARQN---- 219
L ++ I K D+GTYRC+ G + E+ K ++ + + I+ R +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 220 ----------IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
+ N TA +G++V PEP ++W K G++I+ ++D+KY F D
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 270 S--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT----------YVENQT 317
QLTI V +D+AEY +A NK GE L V P T + N
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAE 31805
Query: 318 AMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E + V SG P P++ W + +S ++ +L ++
Sbjct: 31806 CQE-GQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNI----EIIHEGLDYYALHIRDTLP 31860
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQ 403
D G Y TA+NT G S +L+V+
Sbjct: 31861 EDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 83.2 bits (204), Expect = 9e-16
Identities = 83/299 (27%), Positives = 122/299 (40%), Gaps = 23/299 (7%)
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN 452
Q++ ++L+V KL + V G ++ + V P I+W + +L
Sbjct: 13685 QEAPEIFLDV----KLLAGLTVKA--GTKIELPATVTGKPEPKITWTKADMILKQDK--R 13736
Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS-IDQVEPY 511
I I N P S + + +D G Y AVN G+ + + D P P+ D +
Sbjct: 13737 ITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVT 13796
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETT 571
+ + + ++ P GG I Y E RA EVWH K+ + + I P
Sbjct: 13797 NESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLI----PNKE 13852
Query: 572 YAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP--KLEGQMGEDGNSIKVNLI---KQD 626
Y R+AA N G+GE AS T Q +P P +LE D V L D
Sbjct: 13853 YIFRVAAENMYGVGEPVQASPI-TAKYQFDPPGPPTRLE---PSDITKDAVTLTWCEPDD 13908
Query: 627 DGGSPIRHYLV-RYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
DGGSPI Y V R + +W ++P +K L +Y V+AEN G K
Sbjct: 13909 DGGSPITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK 13967
Score = 82.0 bits (201), Expect = 2e-15
Identities = 83/346 (23%), Positives = 143/346 (41%), Gaps = 22/346 (6%)
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYL 400
W+TS +++ E T+ G + +KS+ A + ++ I ++ +
Sbjct: 26130 WKTSIQSLRGTEYTISGLTTGAEYV----FRVKSVNKVGASDPSDSSDPQIAKEREE--- 26182
Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460
E + + + G +T P + W + L + Y + T S
Sbjct: 26183 EPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAY----VDTTDS 26238
Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQF 519
+ L + + ND G Y T N + SL ++ DTP P+ V+ + +A + +
Sbjct: 26239 RTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSW 26298
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
D PE GG P+ Y E R ++ W S + S + + L+ Y R++
Sbjct: 26299 DVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYK----VTNLQEGAIYYFRVSGE 26354
Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVR 638
N G+G + E + +PS P+ G +S+ + +K + DGGS I HY+V
Sbjct: 26355 NEFGVGIPAETKE--GVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV- 26411
Query: 639 YRALSSEWKPEIRLP-SGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
AL K ++ + S H ++ L N+EY V AENQ G S
Sbjct: 26412 -EALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLS 26456
Score = 80.9 bits (198), Expect = 5e-15
Identities = 98/409 (23%), Positives = 161/409 (39%), Gaps = 48/409 (11%)
Query: 315 NQTAMELEEQVTLTCEASGDPIPS--ITWRTSTRNISS---EEKTLDG---------HMV 360
N+ + L + T + S P+P +T TRN ++ E+ DG M
Sbjct: 25276 NEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQ 25335
Query: 361 VRSHARVSSLT-LKSIQYTDAG-----EYI--CTASNTIGQDSQSMY------LEVQYAP 406
+ + S+ T +K+++ T +G EY+ A N G+ +++ P
Sbjct: 25336 TKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKP 25395
Query: 407 KLQGPVAVYTWEGN-QVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465
++ P + + Q+ I P AT++W +DGQ L + N+ T ++ L
Sbjct: 25396 SVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTS--LS 25453
Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS---IDQVEPYSSTAQVQFDEP 522
+ S+ D G Y N G ++ ++ D P P ID+V S T + ++ P
Sbjct: 25454 IKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSIT--ISWNPP 25511
Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582
E GG I Y E + WH +A + IV L + Y R+ A N
Sbjct: 25512 EYDGGCQISNYIVEKKETTSTTWHI----VSQAVARTSIKIVRLTTGSEYQFRVCAENRY 25567
Query: 583 GLGEISAAS----EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVR 638
G S +S E+ P G P PK+ + + +DGGS + Y +
Sbjct: 25568 GKSSYSESSAVVAEYPFSP-PGPPGTPKVVH--ATKSTMLVTWQVPVNDGGSRVIGYHLE 25624
Query: 639 YRALSSE-WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
Y+ SS W ++ + + LD YE V AEN G K +
Sbjct: 25625 YKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCS 25673
Score = 80.5 bits (197), Expect = 6e-15
Identities = 127/573 (22%), Positives = 210/573 (36%), Gaps = 51/573 (8%)
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
I+ V PPT+ W R + + + +S++ + I+ +++ +G Y +LA+
Sbjct: 16544 IIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMV-IKNCQRSHQGVYS----LLAK 16598
Query: 197 GEINFKDIQVIVNV--PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
E + +IV+V P + + N +T + P ++ I
Sbjct: 16599 NEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYV-----I 16653
Query: 255 EQEEDDEK----YIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD--ATIHLKVFAKP 308
E+ E D + ++ T++ + + + AEN G T V +P
Sbjct: 16654 EKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREP 16713
Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG---HMVVRSHA 365
IT E +E++E T + +P P + N E + + H V +
Sbjct: 16714 -ITVPERPEDLEVKEVTKNTVTLTWNP-PKYDGGSEIINYVLESRLIGTEKFHKVTNDNL 16771
Query: 366 RVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLE-VQYAPKLQGPVAVYTWEGNQVNI 424
T+K ++ D EY +A N +GQ S + + +L P +
Sbjct: 16772 LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIR 16831
Query: 425 TCEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
E FA P +SWF+D + + ++IK TP+ LE +D G Y
Sbjct: 16832 VGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIK--TTPATLALEKIKAKRSDSGKY 16889
Query: 478 NCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPILKY 533
N G + D P P S D+V + + P GG I Y
Sbjct: 16890 CVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVT--KDYMVISWKPPLDDGGSKITNY 16947
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
E + VG++V W AS + + L Y R+ A N G+ + +
Sbjct: 16948 IIEKKEVGKDV----WMPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSM 17003
Query: 594 KTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYR-ALSSEWKPEIRL 652
K + P AP +S V K DGG PI +Y++ R +S W R+
Sbjct: 17004 KAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKPITNYILEKRETMSKRW---ARV 17060
Query: 653 PSGSDHVMLK----SLDWNAEYEVYVVAENQQG 681
H K L +YE V AEN+ G
Sbjct: 17061 TKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIG 17093
Score = 80.5 bits (197), Expect = 6e-15
Identities = 114/514 (22%), Positives = 202/514 (39%), Gaps = 55/514 (10%)
Query: 217 RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTI 274
R+ + + T LG++ L C G P P + W + G+++ Q KY S D + LT+
Sbjct: 30536 RKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQ---SRKYKMSSDGRTHTLTV 30592
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI---TYVENQTAMELEEQVTLTCEA 331
++ DE Y CIA N+ GE + + L + A P+ ++ + + + L
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ-YTDAGEYICTASNT 390
G P+P++TW + + + E ++ + + + L +K++Q T AG+Y SN
Sbjct: 30653 IGRPVPAMTWFHGQKLLQNSE-----NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNV 30707
Query: 391 IGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWF---------- 439
G + +E+Q P K GP+ + N I+ + A SW
Sbjct: 30708 FGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGG--SWITNYVVEKCEA 30765
Query: 440 ---RDGQLLPSS-NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ QL+ S+ + + +I N + ++N FG + V+ + ++
Sbjct: 30766 KEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSV--VIIKSPFE 30823
Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+ P P+I V + V + P + GG I Y E R + W S E
Sbjct: 30824 KPGAPGKPTITAVT--KDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISV---TTEE 30878
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDG 615
E + ++ L Y R+ N G E S SE P+ + P E+
Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISE----PITPKSDVPIQAPHFKEEL 30934
Query: 616 NSIKVN-------LIKQDDGGSPI-RHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWN 667
++ V + K PI + Y ++ K I+ G H ++ + +
Sbjct: 30935 RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTD 30994
Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 701
+ VY V QG S V T++ +PA
Sbjct: 30995 DDATVYQVRATNQGGS-----VSGTASLEVEVPA 31023
Score = 80.5 bits (197), Expect = 6e-15
Identities = 84/399 (21%), Positives = 168/399 (42%), Gaps = 33/399 (8%)
Query: 21 QVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQ-RISVVWNDDSSS 79
++ +Q I+ G+ +AG D+ W NG +LT +++ R V +D
Sbjct: 33040 EIKAFSTQMSINEGQRLVLKANIAGAT---DVKWVL-NGVELTNSEEYRYGVSGSDQ--- 33092
Query: 80 TLTIYNANIDDAGIYKCVVTGEDG---SESEATVNVKIFQKLMFKNAPTPQEFREGEDAV 136
TLTI A+ D GI C+ ++G + + T++ ++ F + P Q EG++ +
Sbjct: 33093 TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVL 33152
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA 195
C++ P I W + + +V N Y L+IR +D G Y + +
Sbjct: 33153 FTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNF- 33211
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATAN--------LGQSVTLVCDAEGFPEPTMSW 247
RG+ + ++ +P + + +V T+ QSV + + E + S
Sbjct: 33212 RGQCSATASLMV--LPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQ---EASFSS 33266
Query: 248 TKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK 307
E + + S + V+ + + ++ I+ E + LK +
Sbjct: 33267 FSSSSASSMTEMKFASMSAQSMSSMQESFVEMS-SSSFMGISNMTQLESSTSKMLKAGIR 33325
Query: 308 ---PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
PKI + + +++ + +T+ C +G+P P +TW R I S+E+ G + +
Sbjct: 33326 GIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ---GRFHIENT 33382
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
+++L + +Q D G Y + N G DS ++ + ++
Sbjct: 33383 DDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 79.3 bits (194), Expect = 1e-14
Identities = 80/308 (25%), Positives = 119/308 (38%), Gaps = 23/308 (7%)
Query: 406 PKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYL 464
P L+ P Y+ + G + I V P ISW +DG+ P + + + T +++ L
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGE--PLKQTTRVNVEETATSTVL 24369
Query: 465 EVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEP 522
+ +++DFG Y TA N G E+L I+++ P + E + + ++ P
Sbjct: 24370 HIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPP 24429
Query: 523 EATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGK 582
TGG I Y E R WH + I LK T Y R+ A N
Sbjct: 24430 AYTGGCQISNYIVEKRDTTTTTWHM----VSATVARTTIKITKLKTGTEYQFRIFAENRY 24485
Query: 583 GLGEISAASEFKTQPVQ------GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYL 636
G SA + K VQ G P P + + +D ++ + D G I ++L
Sbjct: 24486 GK---SAPLDSKAVIVQYPFKEPGPPGTPFVT-SISKDQMLVQWHEPVNDGGTKIIGYHL 24541
Query: 637 VRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRT 692
+ S W + P LD EYE V AEN G K + FV R
Sbjct: 24542 EQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARD 24601
Query: 693 SAQPTAIP 700
P P
Sbjct: 24602 PCDPPGRP 24609
Score = 77.4 bits (189), Expect = 5e-14
Identities = 102/434 (23%), Positives = 169/434 (38%), Gaps = 33/434 (7%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAG-----EQDATIHLKVFA--KPKITYVENQTAMELEE 323
Q TI + + E E+ AEN+ G +I K+ + P I +L E
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548
Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
L+C+ G P+P I W + + K + S R +LT+ + + D G Y
Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRFGKELIQSRK-----YKMSSDGRTHTLTVMTEEQEDEGVY 30603
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAV----YTWEGNQVNITCEVFAYPSATISWF 439
C A+N +G+ S L +Q P+ + Y G+ + + P ++WF
Sbjct: 30604 TCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF 30663
Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEV-TPDSENDFGNYNCTAVNRIGQ-ESLEFILVQ- 496
+LL N NI I NT ++L + + G Y N G +++ + +Q
Sbjct: 30664 HGQKLL--QNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQD 30721
Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
D P+ P + + ++A + + P GG I Y E E ++W A
Sbjct: 30722 KPDKPTGPIVIEA-LLKNSAVISWKPPADDGGSWITNYVVEKCEAKE---GAEWQLVSSA 30777
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQ-PVQGEPSAPKLEGQM 611
IV L Y R++A N G+ E+S+ K+ G P P +
Sbjct: 30778 ISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVT 30837
Query: 612 GEDGNSIKVNLIKQDDGGSPIR-HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEY 670
+ + + DGG+ IR +YL + ++W +K+L EY
Sbjct: 30838 KD--SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEY 30895
Query: 671 EVYVVAENQQGKSK 684
E V EN G+S+
Sbjct: 30896 EFRVKCENLGGESE 30909
Score = 77.0 bits (188), Expect = 7e-14
Identities = 90/356 (25%), Positives = 142/356 (39%), Gaps = 29/356 (8%)
Query: 365 ARVSSLTLKSIQYTDAGEYI--CTASNTIGQ-DSQSMYL-----EVQYAPKLQGPVAVYT 416
ARV SL T EY+ A N G+ D +S+ + ++ P ++ + Y+
Sbjct: 23181 ARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYS 23240
Query: 417 WE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG 475
+ G + I + P TI+W +DG LP + I + ++ + L + ++D G
Sbjct: 23241 VQVGQDLKIEVPISGRPKPTITWTKDG--LPLKQTTRINVTDSLDLTTLSIKETHKDDGG 23298
Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP----SIDQVEPYSSTAQVQFDEPEATGGVPIL 531
Y T N +GQ++ +V D P P D V S T + ++ P TGG I
Sbjct: 23299 QYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT--LSWNPPLYTGGCQIT 23356
Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
Y + R VW D A++ + + LK T Y R+ A N G +
Sbjct: 23357 NYIVQKRDTTTTVW-----DVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALES 23411
Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSP-IRHYLVRYRALSSEWKP 648
Q EP P +S+ + + ++GGSP I ++L R S W
Sbjct: 23412 DPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTK 23471
Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRTSAQPTAIP 700
+ ++L+ EYE V AEN G KA+ +V R P P
Sbjct: 23472 VNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP 23527
Score = 77.0 bits (188), Expect = 7e-14
Identities = 149/666 (22%), Positives = 258/666 (38%), Gaps = 110/666 (16%)
Query: 76 DSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDA 135
DS STLT+ N N +DAG Y V GS+S T VK+ P P F++
Sbjct: 28408 DSFSTLTVENCNRNDAGKYTLTVENNSGSKS-ITFTVKVLDT---PGPPGPITFKD---- 28459
Query: 136 VIVCDVVSSLPPTIIWKHKGRD--------VILKKDVRF----IVLSNNYLQIRGIKKTD 183
V+ T++W D V+ K++ ++ QI +
Sbjct: 28460 ------VTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLA 28513
Query: 184 EGT---YRCEG-RILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEG 239
EG +R GE ++ P R ++V+ + + L D +G
Sbjct: 28514 EGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDG 28573
Query: 240 FPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQLT--IKKVDKNDEAEYICIAENKAG-- 294
T G +E +++ + ++ + + QLT ++++ + E E+ A+N AG
Sbjct: 28574 GSRIT------GYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYS 28627
Query: 295 EQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEA----------SGDPIPSITWRTS 344
E + +P+I + T + + +TC+A SG P P +TW+
Sbjct: 28628 EPREAFSSVIIKEPQIEPTADLTGITNQ---LITCKAGSPFTIDVPISGRPAPKVTWKLE 28684
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
+ ++ + + + ++LT+K D+G Y T NT G + S+ + V
Sbjct: 28685 EMRLKETDR-----VSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIG 28739
Query: 405 AP-KLQGPV---------AVYTW----EGNQVNITCEVF-AYPSATISWFRDGQLLPSSN 449
P + GP+ V +W +G IT + S T +W L +S+
Sbjct: 28740 RPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW-----QLVNSS 28794
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQAD----TPSSPS 504
+I T Y+E ++ ++ NR G + LE + A+ PS+P+
Sbjct: 28795 VKRTQIKVTHLTKYMEY---------SFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPT 28845
Query: 505 IDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTI 563
+V S+ A ++++EP GG I+ Y E + +W + K +E +
Sbjct: 28846 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVK---ENKVPCLECNYKV 28902
Query: 564 VGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLEGQMGEDGNSIKVNL 622
GL Y R ALN G+ + S AS Q P P++ D V+L
Sbjct: 28903 TGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEV-----TDVTRSTVSL 28957
Query: 623 I---KQDDGGSPIRHYLVRYRALS----SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675
I DGGS + Y++ + +S W + + +L YE V+
Sbjct: 28958 IWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVL 29017
Query: 676 AENQQG 681
A+N G
Sbjct: 29018 AKNAAG 29023
Score = 76.3 bits (186), Expect = 1e-13
Identities = 111/520 (21%), Positives = 189/520 (36%), Gaps = 72/520 (13%)
Query: 50 KDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSE---- 105
K+++W+ +G+KL N ++ D + L I N D G Y C ++GE G+
Sbjct: 32747 KEVTWYK-DGKKLKENGH-FQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNL 32804
Query: 106 ---------------------------SEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
+E+TV K K + P +D +
Sbjct: 32805 QFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVS 32864
Query: 139 CDVVSSLP--------PTIIWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRC 189
D V+ PT IW G+ + + + L+I +D G Y C
Sbjct: 32865 SDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTC 32924
Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE------GFPEP 243
+ A G ++ ++ + +A++ T+ + V E E
Sbjct: 32925 TVKNSA-GSVS-SSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEI 32982
Query: 244 TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303
MS K E++ +E+ K + S++ + ++K+ E I + E +K
Sbjct: 32983 KMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIK 33042
Query: 304 VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
F+ T M + E L +A+ + W + +++ E+ G
Sbjct: 33043 AFS----------TQMSINEGQRLVLKANIAGATDVKWVLNGVELTNSEEYRYG-----V 33087
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIG----QDSQSMYLEVQYAPK-LQGPVAVYTWE 418
+LT+K + D G C + G Q ++ E+ AP + P + E
Sbjct: 33088 SGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINE 33147
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V TCE+ PS I WF++ LP S SN+ I + + LE+ S +D G Y
Sbjct: 33148 GQNVLFTCEISGEPSPEIEWFKNN--LPISISSNVSISRSRNVYSLEIRNASVSDSGKYT 33205
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518
A N GQ S L+ PS + V S +Q
Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQ 33245
Score = 75.5 bits (184), Expect = 2e-13
Identities = 79/284 (27%), Positives = 106/284 (37%), Gaps = 39/284 (13%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + VF P T+SW +DG LL + IK+ + LE+ + D G+Y
Sbjct: 19310 GTNVCLDATVFGKPMPTVSWKKDGTLLKPA--EGIKMAMQRNLCTLELFSVNRKDSGDYT 19367
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
TA N G +S L D P P S+ + YS A + ++ P GG I Y +
Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPET-----TYAVRLAALNGKGLGEISAASE 592
R W A + V I E Y R+ A N G+G+
Sbjct: 19428 RETSRPNW---------AQVSATVPITSCSVEKLIEGHEYQFRICAENKYGVGD------ 19472
Query: 593 FKTQPVQGEPSAPKLE-GQMGEDGNSIKVNLIKQ----------DDGGSPIRHYLVRYRA 641
PV EP+ K G + N+ K DDGGSPI YL+ R
Sbjct: 19473 ----PVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRE 19528
Query: 642 LSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
+ W R P + L EYE V A N+ G K
Sbjct: 19529 TQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGK 19572
Score = 75.5 bits (184), Expect = 2e-13
Identities = 78/292 (26%), Positives = 129/292 (44%), Gaps = 20/292 (6%)
Query: 401 EVQYAPKLQGPVAVYTW----EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456
++ AP++ VA+ T G V + P T++W +D + L S + I
Sbjct: 27264 DILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSD--ARYSIE 27321
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA-DTPSSPSIDQVEPYS-ST 514
NT S+S L + + ND G Y T N +G+ + V+ DTP++ QV+ S T
Sbjct: 27322 NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGT 27381
Query: 515 AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAV 574
+ +D P GG PI+ Y E R + W + S + ++ L +T +
Sbjct: 27382 VTLLWDPPLIDGGSPIINYVIEKRDATKRTWSVVSHKCSSTSFK----LIDLSEKTPFFF 27437
Query: 575 RLAALNGKGLGEISAASEFKTQPVQ-GEPSAPKLEGQMGED-GNSIKVNLIKQD-DGGSP 631
R+ A N G+GE T+PV+ E AP + M + S+ ++ K D DGGS
Sbjct: 27438 RVLAENEIGIGEPCET----TEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSV 27493
Query: 632 IRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
I Y+V + + + S + + + L + E V A+N++G S
Sbjct: 27494 ITEYVVERKGKGEQTWSHAGI-SKTCEIEVSQLKEQSVLEFRVFAKNEKGLS 27544
Score = 75.1 bits (183), Expect = 3e-13
Identities = 84/331 (25%), Positives = 128/331 (38%), Gaps = 16/331 (4%)
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419
VVR+ T + + AG S + Q+M E+ Q V G
Sbjct: 21023 VVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKA--G 21080
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
+ + + V P T++W + Q+L + N + T +++ L + +D G Y
Sbjct: 21081 DNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFE--TTATSTILNINECVRSDSGPYPL 21138
Query: 480 TAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
TA N +G+ + D P P+ I E S +D PE GGVPI Y E
Sbjct: 21139 TARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEM 21198
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596
R W + + GL+ Y R+ A N G+G I++A
Sbjct: 21199 RQTDSTTWVELATTVIRTTYKATRLTTGLE----YQFRVKAQNRYGVGPGITSACIVANY 21254
Query: 597 P--VQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSS-EWKPEIRLP 653
P V G P P++ + +D +I + DGGSPI Y V + + W+ +
Sbjct: 21255 PFKVPGPPGTPQVTA-VTKDSMTISWH-EPLSDGGSPILGYHVERKERNGILWQTVSKAL 21312
Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
+ L YE V+AEN GKSK
Sbjct: 21313 VPGNIFKSSGLTDGIAYEFRVIAENMAGKSK 21343
Score = 73.9 bits (180), Expect = 6e-13
Identities = 117/490 (23%), Positives = 188/490 (38%), Gaps = 69/490 (14%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSST-LTIYNANIDDAG 92
G S F CQV G+ K ++ +G LT R V +N + L I DDAG
Sbjct: 1096 GGSVVFGCQVGGNPKPH--VYWKKSGVPLTTGY-RYKVSYNKQTGECKLVISMTFADDAG 1152
Query: 93 IYKCVVTGEDGS---------ESEATVNVKIFQKLMFKNAPTP--QEFREGEDA----VI 137
Y VV + G E++ + +K Q+++++ T QE + GE A
Sbjct: 1153 EYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYS 1212
Query: 138 VCDVVSSLPPTIIWKHKGRDVILKK----DVRFIVLSNNY-----LQIRGIKKTDEGTYR 188
+ +I K +D ++ + D F + S ++ R IK T E
Sbjct: 1213 EYEKEYEKEQALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLE 1272
Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
+G E DI V +R I N G VT C G+P P ++W
Sbjct: 1273 EDGE-----EKMAVDISESEAVESGFDSR--IKNYRILEGMGVTFHCKMSGYPLPKIAWY 1325
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
KDG++I+ E + D + L I V DE Y A N G +A K++ +P
Sbjct: 1326 KDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKG--NAICSGKLYVEP 1383
Query: 309 KITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368
P+ + T+ + + S ++L V RS R+S
Sbjct: 1384 ------------------------AAPLGAPTYIPTLEPV-SRIRSLSPRSVSRSPIRMS 1418
Query: 369 SLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNI 424
+ + + A + A + G +++ LE Y P + PV+ EG
Sbjct: 1419 PARMSPARMSPA--RMSPARMSPGRRLEETDESQLERLYKPVFVLKPVSFKCLEGQTARF 1476
Query: 425 TCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
+V P WF DGQ + ++Y++ + L + P + +D G + A NR
Sbjct: 1477 DLKVVGRPMPETFWFHDGQQI-VNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNR 1535
Query: 485 IGQESLEFIL 494
G+ S+ IL
Sbjct: 1536 AGRSSISVIL 1545
Score = 73.9 bits (180), Expect = 6e-13
Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 13/282 (4%)
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
+ P SW + G+ + S+ + I +TP++S L + + D G Y TA N G
Sbjct: 20403 ILGKPLPKSSWSKAGKDIRPSDITQIT--STPTSSMLTIKYATRKDAGEYTITATNPFGT 20460
Query: 488 ESLEFILVQADTPSSPSIDQVEPYSS-TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546
+ + D P P ++ S+ A + + P GG PI Y E R +W
Sbjct: 20461 KVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWT 20520
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK 606
D + I G Y R++A+N G GE + K G P P+
Sbjct: 20521 VVSEDIQSCRHVATKLIQG----NEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPE 20576
Query: 607 LEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSL 664
N+ V+ + DDGGS I Y V R S W I+ P + L
Sbjct: 20577 KPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGL 20636
Query: 665 DWNAEYEVYVVAENQQG---KSKAAHFV-FRTSAQPTAIPAN 702
+ YE V AEN+ G S+A+ V + +A P P+N
Sbjct: 20637 QEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678
Score = 73.2 bits (178), Expect = 1e-12
Identities = 83/348 (23%), Positives = 134/348 (38%), Gaps = 21/348 (6%)
Query: 252 EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKIT 311
E+I + K + + +K + E+E+ I+E + D I F +
Sbjct: 30877 EEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEEL-- 30934
Query: 312 YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLT 371
+ + TL C+ +G P P + W + I ++ + + L
Sbjct: 30935 ---RNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLK---YRIQEFKGGYHQLI 30988
Query: 372 LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK------LQGPVAVYTWEGNQVNIT 425
+ S+ DA Y A+N G S + LEV+ K L+G AV+ G V+I
Sbjct: 30989 IASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIK 31048
Query: 426 CEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
P I+W + L+ ++ + + I S + D G Y A NR
Sbjct: 31049 IPFSGKPDPVITWQKGQDLIDNNGHYQV-IVTRSFTSLVFPNGVERKDAGFYVVCAKNRF 31107
Query: 486 GQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEV 544
G + L AD P P +V S + + + EP + GG I Y E A E
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAE- 31166
Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
+W +A E T++ L +T+Y R+ A N GL + S SE
Sbjct: 31167 ---RWLRVGQA-RETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSE 31210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 102/442 (23%), Positives = 171/442 (38%), Gaps = 45/442 (10%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAG--EQDATIHLKVFAKPKIT-YVENQTAMELEE--QV 325
Q T++ + + E E+ A N AG + AT+ +P + ++ + ME+EE V
Sbjct: 16075 QFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNV 16134
Query: 326 TLTCEASGDPIPSITW-RTSTRNISSEEKTL-DGHMVVRSHARVSSLTLKSIQYTDAGEY 383
+ + G P P++TW + + ++E L D H+ +L + + +D G Y
Sbjct: 16135 NIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY 16194
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWF--R 440
TA N +G S+ M L V P GP+ + +Q+ T+SWF +
Sbjct: 16195 TITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQM------------TLSWFPPK 16242
Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---- 486
D +NY + + + + P + E + A N+ G
Sbjct: 16243 DDGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEP 16302
Query: 487 ----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542
E+ + P P++ V S T V ++EPE GG P+ Y E +
Sbjct: 16303 LDSEPETARNLFSVPGAPDKPTVSSVTRNSMT--VNWEEPEYDGGSPVTGYWLEMKDTTS 16360
Query: 543 EVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGE 601
+ W D +A G+ + GL + Y R+ A+N G+G S S+ T
Sbjct: 16361 KRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIA 16420
Query: 602 PSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHV 659
P P +S + DGGS + Y+V Y+ EW+ +
Sbjct: 16421 PPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 16480
Query: 660 MLKSLDWNAEYEVYVVAENQQG 681
++ L A Y+ V A N G
Sbjct: 16481 VVTGLKEGAFYKFRVRAVNIAG 16502
Score = 71.6 bits (174), Expect = 3e-12
Identities = 131/548 (23%), Positives = 215/548 (39%), Gaps = 70/548 (12%)
Query: 190 EGRILARGEINFKDI-QVIVNVPPTIQARQNI--VNATANLGQSVTLVCDAEGFPEPTMS 246
+ +LA E F+ + V V PTI+ + I +N G+ L +G +
Sbjct: 18061 KANLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLK 18120
Query: 247 WTK---DG----------EQIEQEEDDEK-YIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
W + DG +++ +D E+ + S + + + +N E+ +N+
Sbjct: 18121 WRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNE 18180
Query: 293 AGEQDATIHLKVFAKPKITY------VENQTAMELEEQVTLTCEASGDPIPSITWRTSTR 346
GE D +V K + + ++ + + L G P P + W T+
Sbjct: 18181 GGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAW---TK 18237
Query: 347 NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP 406
+ + + T + + + A S +L + +D G+Y+ TA+NT G S Y V
Sbjct: 18238 DKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAG--SFVAYATVNVLD 18295
Query: 407 KLQGPV------------AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIK 454
K GPV W+ + + CE+ Y I + + + S YS
Sbjct: 18296 K-PGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNY----ILEKCETKRMVWSTYSATV 18350
Query: 455 IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFIL-VQADTPSSPSIDQVE 509
+ TP + + +E F A N+IG ES I + D P P +V
Sbjct: 18351 L--TPGTTVTRLIEGNEYIF---RVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVT 18405
Query: 510 PYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA-KEASMEGIVTIVGLK 567
S V ++ PE GG I Y E +E ++W K A E + + L
Sbjct: 18406 KVSKEEMTVVWNPPEYDGGKSITGYFLE----KKEKHSTRWVPVNKSAIPERRMKVQNLL 18461
Query: 568 PETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLIKQ- 625
P+ Y R+ A N G+GE S S EP P ++ + +SI + K
Sbjct: 18462 PDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPV 18521
Query: 626 DDGGSPIRHYLVRYRALSSEWKPE---IRLPSGSDHV----MLKSLDWNAEYEVYVVAEN 678
DGG+PI Y+V R ++ P+ R + + V + SLD N EYE V A+N
Sbjct: 18522 YDGGAPIIGYVVEMRPKIADASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVCAQN 18581
Query: 679 QQGKSKAA 686
Q G + A
Sbjct: 18582 QVGIGRPA 18589
Score = 71.2 bits (173), Expect = 4e-12
Identities = 73/258 (28%), Positives = 106/258 (41%), Gaps = 19/258 (7%)
Query: 432 PSATISWFRDGQLLPSSNYS-NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
P+ T W + P SN S I+ T S S L V + ND G Y T N G +S+
Sbjct: 28385 PTPTAVWSK-----PDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSI 28439
Query: 491 EFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549
F + DTP P I + +A + +D P GG I Y E R E W
Sbjct: 28440 TFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKR----EASRRSW 28495
Query: 550 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG--EPSAPKL 607
E I + L Y R++A+N G+GE E P+ +P+ P+
Sbjct: 28496 QVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPE----PIVATEQPAPPRR 28551
Query: 608 EGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDW 666
+ +S + +K D DGGS I YL+ R S++ E + + ++
Sbjct: 28552 LDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVE- 28610
Query: 667 NAEYEVYVVAENQQGKSK 684
EYE V A+N G S+
Sbjct: 28611 KTEYEFRVKAKNDAGYSE 28628
Score = 70.9 bits (172), Expect = 5e-12
Identities = 73/286 (25%), Positives = 116/286 (40%), Gaps = 20/286 (6%)
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
EG +++I A P T+SW +DG+ + +S+ +K N +++LEV D G Y
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMK--NDHISAHLEVPKSVRADAGIY 14457
Query: 478 NCTAVNRIGQESLEFILVQADTPSS-PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
T N++G + + P I + S+ ++ ++ PE GG PIL Y E
Sbjct: 14458 TITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYVLE 14517
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596
R G + + S T+ L P Y R+ A+N G GE
Sbjct: 14518 RREAGRRTYIPVMSGENKLSW----TVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIA 14573
Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD--DGGSPIRHYLVRYRALSSEWKPEIRLPS 654
+P P ++ ++ K DGGS I Y++ A K E R
Sbjct: 14574 QDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIA-----KGEERWKR 14628
Query: 655 GSDHVM------LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSA 694
++H++ K L+ EY+ V AEN G S+ + T A
Sbjct: 14629 CNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKA 14674
Score = 70.1 bits (170), Expect = 8e-12
Identities = 135/629 (21%), Positives = 238/629 (37%), Gaps = 73/629 (11%)
Query: 49 DKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEA 108
+ ++ W G + ++ +I V S + L I N D+G Y + GS++ A
Sbjct: 25136 EPEVKWEKAEG--ILTDRAQIEVT---SSFTMLVIDNVTRFDSGRYNLTLENNSGSKT-A 25189
Query: 109 TVNVKIFQKLMFKNAPTPQEFRE-GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-- 165
VNV++ +AP RE +D+V +S PP I K + I++K
Sbjct: 25190 FVNVRVLDS---PSAPVNLTIREVKKDSV----TLSWEPPLIDGGAKITNYIVEKRETTR 25242
Query: 166 --FIVLSNNYLQIR-GIKKTDEGTYRCEGRILARGEINF-----KDIQVIVNVPPTIQAR 217
+ ++NN + I+ EG R+LA E V V+ PP R
Sbjct: 25243 KAYATITNNCTKTTFRIENLQEGC-SYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGR 25301
Query: 218 QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE-QEEDDEKYIFSDDSSQL--TI 274
+V+ T N +++G + T G +E Q + EK+ L TI
Sbjct: 25302 VTLVDVTRNTATIKWEKPESDGGSKIT------GYVVEMQTKGSEKWSTCTQVKTLEATI 25355
Query: 275 KKVDKNDEAEYICIAENKAGEQDA------TIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ +E + A N+ G D I + KP + + ++ EQ+ +
Sbjct: 25356 SGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKID 25415
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
G P ++ WR + + + + V S V+SL++K D G Y S
Sbjct: 25416 VPFKGRPQATVNWRKDGQTLKETTR-----VNVSSSKTVTSLSIKEASKEDVGTYELCVS 25470
Query: 389 NTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNITCEVFAY-----PSA 434
N+ G + + + V P GP+ + +W + + C++ Y +
Sbjct: 25471 NSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETT 25530
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ +W Q + ++IKI + S + +EN +G + + + + E+
Sbjct: 25531 STTWHIVSQAVAR---TSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAV---VAEYPF 25584
Query: 495 VQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
P +P + V ST V + P GG ++ Y E++ +W K
Sbjct: 25585 SPPGPPGTPKV--VHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKA---NKI 25639
Query: 555 ASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED 614
+ + + GL Y R+ A N G+G+ S + E P + P
Sbjct: 25640 LIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE--PVPARDPCDPPGQPEVTNIT 25697
Query: 615 GNSIKVNLIKQD-DGGSPIRHYLVRYRAL 642
S+ + K DGG+ I Y+V R L
Sbjct: 25698 RKSVSLKWSKPHYDGGAKITGYIVERREL 25726
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/411 (24%), Positives = 162/411 (39%), Gaps = 49/411 (11%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G + L +G P P WTK+G+ I + S+ ++L IK+ D+ D Y
Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKR---AMIATSETHTELVIKEADRGDSGTYDL 30207
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
+ ENK G++ I ++V P + +E ++ + S P P+
Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPN----SPEGPLEYDDIQVRSVRVSWRP-PADDGGADILG 30262
Query: 348 ISSEEKTLD--GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYA 405
E + + + S R +SL +K ++ + +A N G S+ + E
Sbjct: 30263 YILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFG-ISKPLKSEEPVT 30321
Query: 406 PKLQ-GPVAVYTWEGNQVNITCEVFAYPSATISWFR---DGQLLPSSNYSNIKIYNTP-- 459
PK P + +++T S ++SW R DG + Y K +T
Sbjct: 30322 PKTPLNPPEPPSNPPEVLDVT-----KSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKW 30376
Query: 460 --------SASYLEVT---PDSENDFGNYNCTAVNRIG----QESLEFILVQ--ADTPSS 502
+ + VT PD+E F A N +G + E ++ + D PS
Sbjct: 30377 VRHNKTQITTTMYTVTGLVPDAEYQF---RIIAQNDVGLSETSPASEPVVCKDPFDKPSQ 30433
Query: 503 P-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIV 561
P ++ + + +Q+++PE GG IL Y E+R G+ W KE +
Sbjct: 30434 PGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKK---SNKERIKDKQF 30490
Query: 562 TIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQPVQGEPSAPKLEGQM 611
TI GL T Y R+ A N GL A KT+ GE AP + +M
Sbjct: 30491 TIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGE--APGIRKEM 30539
Score = 69.3 bits (168), Expect = 1e-11
Identities = 66/300 (22%), Positives = 124/300 (41%), Gaps = 33/300 (11%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD--KNDEAEY 285
GQ+ + + + P + W +G ++++ K +++ S LT++ +D +D Y
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQESS---KIHYTNTSGVLTLEILDCHTDDSGTY 32444
Query: 286 ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTST 345
+ N GE L V TY + E+ V P +T RT
Sbjct: 32445 RAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSV----------FPELT-RTEA 32493
Query: 346 RNISSEEKTLDGHMV-----VRSHARVSSLTLKSIQYTDAGEYICTA--SNTIGQDSQSM 398
+SS +KT + V+S + +L S +++ + E A ++ + S +
Sbjct: 32494 YAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTR 32553
Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 457
++ A + L P ++ +EG +C+ P T++W R GQ+L +S + ++
Sbjct: 32554 KIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTS--ARHQVTT 32611
Query: 458 TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL-------VQADTPSSPSIDQVEP 510
T S E++ +D GNY+ N G++ EF L + S P + EP
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEP 32671
Score = 68.6 bits (166), Expect = 2e-11
Identities = 89/328 (27%), Positives = 137/328 (41%), Gaps = 46/328 (14%)
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P+P+ W T I ++E H V + S LT+K+ D GEY T SN G
Sbjct: 17536 GVPVPTAKWTTDGSEIKTDE-----HYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAG 17590
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDGQLLPSSNY 450
+ +++L V P GP T N +++T E TISW +D P NY
Sbjct: 17591 SKTVAVHLTVLDVP---GPP---TGPINILDVTPE-----HMTISWQPPKDDGGSPVINY 17639
Query: 451 SNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ 496
K + + S + L++ + + A N+IG +S +
Sbjct: 17640 IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKH 17699
Query: 497 ADTPSSPSIDQV--EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
+P SP V + + A V + P++ GG PI Y E R V KW +
Sbjct: 17700 KFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREV-----TGKWVRVNK 17754
Query: 555 ASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASE--FKTQPVQ--GEPSAPKLEG 609
+ + + GL TY R+ A N GL + S +S+ +P++ G P PKL+
Sbjct: 17755 TPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKD 17814
Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLV 637
+ E + + + DGGSPI Y+V
Sbjct: 17815 KSRETADLVWTKPL--SDGGSPILGYVV 17840
Score = 67.8 bits (164), Expect = 4e-11
Identities = 96/395 (24%), Positives = 157/395 (39%), Gaps = 58/395 (14%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E L + G PIP + W + + E+T M ++S + ++L +K TD G+
Sbjct: 24723 ETFVLEADIRGKPIPDVVWSKDGKEL---EETA-ARMEIKSTIQKTTLVVKDCIRTDGGQ 24778
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAV---------YTW----EGNQVNITCEV 428
YI SN G S + ++V P +GP+ V W + NI+ +
Sbjct: 24779 YILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYI 24838
Query: 429 F-AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG- 486
++ +SW + + + NY K+ P Y+ + AVN+ G
Sbjct: 24839 IEKRETSRLSWTQVSTEVQALNYKVTKL--LPGNEYI------------FRVMAVNKYGI 24884
Query: 487 QESLEFILVQA----DTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVG 541
E LE V A P PS +V + + V + P GG I Y E R
Sbjct: 24885 GEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKR--- 24941
Query: 542 EEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEF----KTQ 596
+ +W + ++ + + + GL +Y R+AA N G+GE S S F
Sbjct: 24942 -DKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDAL 25000
Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVRYRALSSEWKPEIRLP 653
G PS PK+ D + V+L DGG+P++ Y+V + +++ P
Sbjct: 25001 YPPGPPSNPKV-----TDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTCTPP 25055
Query: 654 SG--SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
+G + L N EY + A N +G + A
Sbjct: 25056 TGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPA 25090
Score = 67.4 bits (163), Expect = 5e-11
Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 23/295 (7%)
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNY-----SNIKIYNTPSASYLEVTPDSEN 472
EG VNI ++ P T++WF+ P + +++ L + +
Sbjct: 16130 EGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRS 16189
Query: 473 DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVP 529
D G Y TAVN +G S E L P P + ++ S +A + + P+ GG
Sbjct: 16190 DTGLYTITAVNNLGTASKEMRLNVLGRP-GPPVGPIKFESVSADQMTLSWFPPKDDGGSK 16248
Query: 530 ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISA 589
I Y E R + W + KE + TI L Y R+ A N G+GE
Sbjct: 16249 ITNYVIEKREANRKTWVHVSSEPKECT----YTIPKLLEGHEYVFRIMAQNKYGIGEPLD 16304
Query: 590 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYR-ALSSEWK 647
+ + + P AP NS+ VN + + DGGSP+ Y + + S WK
Sbjct: 16305 SEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWK 16364
Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702
R P +K++ Y+V + E + + + + P ++P++
Sbjct: 16365 RVNRDP-------IKAMTLGVSYKVTGLIEGSDYQFR-VYAINAAGVGPASLPSD 16411
Score = 67.4 bits (163), Expect = 5e-11
Identities = 65/271 (23%), Positives = 103/271 (38%), Gaps = 13/271 (4%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + P T W DG + + + ++ N +S L + D G Y
Sbjct: 17525 GTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNF--SSVLTIKNCLRRDTGEYQ 17582
Query: 479 CTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
T N G +++ L D P P+ I V P T + + P+ GG P++ Y
Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT--ISWQPPKDDGGSPVINYI 17640
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E + ++ W S + + I L+ Y R+ A N G+G ++
Sbjct: 17641 VEKQDTRKDTWGV----VSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTV 17696
Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP 653
+ PS P N+ V+ + + DGGSPI Y + R ++ +W + P
Sbjct: 17697 AKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTP 17756
Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
+ L YE V AEN G SK
Sbjct: 17757 IADLKFRVTGLYEGNTYEFRVFAENLAGLSK 17787
Score = 67.4 bits (163), Expect = 5e-11
Identities = 115/500 (23%), Positives = 191/500 (38%), Gaps = 63/500 (12%)
Query: 235 CDAEGFPEP--------TMSWTK---DGEQIEQEEDDEKYIFSDD-----------SSQL 272
CD G PEP T+ WTK DG + EK D +Q
Sbjct: 23521 CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF 23580
Query: 273 TIKKVDKNDEAEYICIAENKAGE-------------QDATIHLKVFAKPKITYVENQTAM 319
T+ + ++ E+ IA+N AG +D ++ PK + +
Sbjct: 23581 TVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKF---RDTIVV 23637
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E L + G P+P+I W + I + +++ + L +K D
Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDKEIEESARC-----EIKNTDFKALLIVKDAIRID 23692
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
G+YI ASN G S + ++V P +GPV V + ++T +
Sbjct: 23693 GGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDIS 23752
Query: 439 FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESLEFILVQA 497
+ +S + + + + L+VT E + + AVN+ G E LE V
Sbjct: 23753 HYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 23812
Query: 498 DTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552
P S++ + V ++ P++ GG I+ Y E R + +W
Sbjct: 23813 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKR----DRSGIRWIKC 23868
Query: 553 KEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS-EFKTQPVQGEPSAPKLEGQ 610
+ + + + + GL + Y R++A N G+GE S A+ +K +P P
Sbjct: 23869 NKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHI 23928
Query: 611 MGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RALSSEWKPEIRLPSGSDHVM---LKSLD 665
+ NSI + K DGGS I Y+V +A EW +I P V + L
Sbjct: 23929 VDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEW--QIVTPQTGLRVTRFEISKLT 23986
Query: 666 WNAEYEVYVVAENQQGKSKA 685
+ EY++ V A N+ G +A
Sbjct: 23987 EHQEYKIRVCALNKVGLGEA 24006
Score = 67.4 bits (163), Expect = 5e-11
Identities = 117/517 (22%), Positives = 194/517 (37%), Gaps = 66/517 (12%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ LT G P P W ++IS M+ S + L +K D+G Y
Sbjct: 30154 IRLTIPIKGKPFPICKWTKEGQDISKRA------MIATSETH-TELVIKEADRGDSGTYD 30206
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
N G+ +++Y++V+ P ++ QV + P+ G +
Sbjct: 30207 LVLENKCGK--KAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYI 30264
Query: 445 LPSSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFI---- 493
L Y S + L V EN ++ +A N+ G +S E +
Sbjct: 30265 LERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKT 30324
Query: 494 -LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW--HSKWY 550
L + PS+P + ++ S+ + + P+ GG + Y E + + W H+K
Sbjct: 30325 PLNPPEPPSNPP-EVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQ 30383
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLEG 609
+ T+ GL P+ Y R+ A N GL E S ASE + +PS P
Sbjct: 30384 ITTT-----MYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELE 30438
Query: 610 QMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALS-SEWKPEIRLPSGSDHVMLKSLDWN 667
+ +S+ + K + DGG I Y V YR S WK + + L
Sbjct: 30439 ILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEA 30498
Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLV 727
EYE V AEN+ G S+ + TA+ TSG + G +
Sbjct: 30499 TEYEFRVFAENETGLSR---------PRRTAMSIKTKLTSGEAPG-----------IRKE 30538
Query: 728 VVDITCYFLNKCGLFMCIAVNLCGKAGPGAK----GKDMEEGKAAFSKDESKEPIVEVRT 783
+ D+T K G ++ + G+ P K GK++ + + + + + V T
Sbjct: 30539 MKDVT----TKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMT 30594
Query: 784 EEERTPNHDGGKHT--EPNETTPLTEPEKGPVEAKPE 818
EE+ D G +T NE + K ++A P+
Sbjct: 30595 EEQ----EDEGVYTCIATNEVGEVETSSKLLLQATPQ 30627
Score = 67.4 bits (163), Expect = 5e-11
Identities = 86/413 (20%), Positives = 160/413 (38%), Gaps = 35/413 (8%)
Query: 95 KCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
K +V E S+A+ V+ ++ K T EG+ V+ ++ + + W
Sbjct: 33018 KSIVHEEITKTSQASEEVRTHAEI--KAFSTQMSINEGQRLVLKANIAGATD--VKWVLN 33073
Query: 155 GRDVILKKDVRFIVL-SNNYLQIRGIKKTDEGTYRC-----EGRILARGEINFK----DI 204
G ++ ++ R+ V S+ L I+ DEG C EG + + ++ D
Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133
Query: 205 QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI 264
++ P + QNI N GQ+V C+ G P P + W K+ I +
Sbjct: 33134 PAFISQPRS----QNI-----NEGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSIS 33183
Query: 265 FSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQ 324
S + L I+ +D +Y A+N G+ AT L V P + + +
Sbjct: 33184 RSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVL--PLVEEPSREVVLRTSGD 33241
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT----DA 380
+L S + ++ + SS + M A +S+ ++ S+Q + +
Sbjct: 33242 TSLQGSFSSQSV-QMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSS 33300
Query: 381 GEYICTASNTIGQDSQSMYLEVQYA---PKLQG-PVAVYTWEGNQVNITCEVFAYPSATI 436
++ ++ T + S S L+ PK++ P + EG + + C P+ +
Sbjct: 33301 SSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEV 33360
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
+W G+ + S I NT + L + + D G Y + N G +S
Sbjct: 33361 TWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDS 33413
Score = 67.0 bits (162), Expect = 7e-11
Identities = 77/295 (26%), Positives = 116/295 (39%), Gaps = 36/295 (12%)
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLE 465
PK + + V+ G + +++ P TI W + Q L SN + ++I +T A+ L
Sbjct: 22547 PKYKDTIVVHA--GESFKVDADIYGKPIPTIQWIKGDQEL--SNTARLEIKSTDFATSLS 22602
Query: 466 VTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDE 521
V D GNY A N G+ S+ + D P P I V T + +
Sbjct: 22603 VKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCT--LAWKP 22660
Query: 522 PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNG 581
P GG I+ Y E R VW DA ++ VT L Y R+ A+N
Sbjct: 22661 PLQDGGSDIINYIVERRETSRLVW--TVVDANVQTLSCKVT--KLLEGNEYTFRIMAVNK 22716
Query: 582 KGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-----------DGGS 630
G+GE P++ EP K + + + +V + +D DGGS
Sbjct: 22717 YGVGE----------PLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGS 22766
Query: 631 PIRHYLVRYRALSS-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
I Y++ R W + G + + L N +YE V AEN G S+
Sbjct: 22767 EILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSE 22821
Score = 67.0 bits (162), Expect = 7e-11
Identities = 85/348 (24%), Positives = 126/348 (36%), Gaps = 57/348 (16%)
Query: 189 CEGRILARGEINFKDIQVI-VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW 247
C G I ++ ++ ++V + + P I++A G V VC E + + T
Sbjct: 31545 CGGAIRSQKGVSVAKVKVASIEIGPV---SGQIMHAVGEEGGHVKYVCKIENYDQSTQVT 31601
Query: 248 TKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
G + Q E+ EKY + D + L +K + K D+ Y C N GE + + ++F
Sbjct: 31602 WYFG--VRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSS--YAELF 31657
Query: 306 AK------------------------------PKITY-VENQTAMELEEQVTLTCEASGD 334
K P+ T + N+TA + E V +
Sbjct: 31658 VKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAY-VGENVRFGVTITVH 31716
Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
P P +TW S + I + D S + LT+ S+ D EY A N G+D
Sbjct: 31717 PEPHVTWYKSGQKIKPGDN--DKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGED 31774
Query: 395 SQSMYLEVQYAPKLQGPVA----------VYTWEGNQVNITCEVFAYPSATISWFRDGQL 444
S L V P EG V V P T+ W +DGQ
Sbjct: 31775 SCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQ- 31833
Query: 445 LPSSNYSNIKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIGQESLE 491
P S NI+I + Y L + D G Y TA N G S +
Sbjct: 31834 -PLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880
Score = 66.6 bits (161), Expect = 9e-11
Identities = 70/274 (25%), Positives = 108/274 (39%), Gaps = 13/274 (4%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + I V P ++WF+DG + N++I + ++ L V + + G Y
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDG--VEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYT 28030
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
A N G E + DTP + + + T + + +D P G PI Y
Sbjct: 28031 VEAKNASGSAKAEIKVKVQDTPGKV-VGPIRFTNITGEKMTLWWDAPLNDGCAPITHYII 28089
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
E R W + S I I G Y R++A+N G+G +
Sbjct: 28090 EKRETSRLAWALIEDKCEAQSYTAIKLING----NEYQFRVSAVNKFGVGRPLDSDPVVA 28145
Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLV-RYRALSSEWKPEI-RL 652
Q P AP + GNSI + + + DGGS I+ Y++ R S+ W I +
Sbjct: 28146 QIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKR 28205
Query: 653 PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
P + L EYE +V+AEN G A+
Sbjct: 28206 PISETRFKVTGLTEGNEYEFHVMAENAAGVGPAS 28239
Score = 66.2 bits (160), Expect = 1e-10
Identities = 76/325 (23%), Positives = 130/325 (40%), Gaps = 16/325 (4%)
Query: 369 SLTLKSIQYTDAGEYICTASNTIG----QDSQSMY--LEVQYAPKLQGPVAVYTWEGNQV 422
SL + ++ ++ A N +G ++++ +Y E PK+ P + G ++
Sbjct: 18857 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKL 18916
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
I V+ P T W + + +S S++ ++ S+S L + + D G Y+ TA
Sbjct: 18917 RIEAHVYGKPHPTCKWKKGEDEVVTS--SHLAVHKADSSSILIIKDVTRKDSGYYSLTAE 18974
Query: 483 NRIGQES--LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAV 540
N G ++ ++ +++ A P P D + + + + P GG I Y E
Sbjct: 18975 NSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKC-- 19032
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600
+V W A + + + L P Y R+ A N G+ E + + Q G
Sbjct: 19033 --DVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFG 19090
Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSS-EWKPEIRLPSGSDH 658
PS PK + + I V + D DGGSPI YL+ + +S W S
Sbjct: 19091 VPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTE 19150
Query: 659 VMLKSLDWNAEYEVYVVAENQQGKS 683
L EY + A N+ G S
Sbjct: 19151 YPCAGLVEGLEYSFRIYALNKAGSS 19175
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/293 (24%), Positives = 122/293 (41%), Gaps = 44/293 (15%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ + SG P P++TW + E+TL + + A SS+ +K+ Q + G Y
Sbjct: 16542 IRIIAYVSGKPPPTVTWNMN-------ERTLPQEATIETTAISSSMVIKNCQRSHQGVYS 16594
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF--RDG 442
A N G+ +++ ++V P GPV N N +C+ ++WF D
Sbjct: 16595 LLAKNEAGERKKTIIVDVLDVP---GPVGTPFLAHNLTNESCK--------LTWFSPEDD 16643
Query: 443 QLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ----E 488
P +NY K + T + V + + A N IG E
Sbjct: 16644 GGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVE 16703
Query: 489 SLEFILVQAD--TPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545
+ E ++++ P P ++ E +T + ++ P+ GG I+ Y E R +G E +
Sbjct: 16704 TSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKF 16763
Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598
H D + T+ GLK TY R++A+N G G+ S F T+P+
Sbjct: 16764 HKVTNDNL---LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPS----FCTKPI 16809
Score = 65.5 bits (158), Expect = 2e-10
Identities = 99/405 (24%), Positives = 150/405 (37%), Gaps = 49/405 (12%)
Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
VPP+++ ++ G +V G P PT WT DG +I+ DE Y D
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKT---DEHYTVETD 17562
Query: 269 --SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVT 326
SS LTIK + D EY N AG + +HL V P E +T
Sbjct: 17563 NFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMT 17622
Query: 327 LTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
++ + D P I + + ++ D VV S + + L + +Q +
Sbjct: 17623 ISWQPPKDDGGSPVINY-----IVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFR 17677
Query: 385 CTASNTIG----QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF- 439
A N IG DS + +++P V T +IT +AT+SW
Sbjct: 17678 VRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVT------DIT-----ENAATVSWTL 17726
Query: 440 --RDGQLLPSSNYSN--------IKIYNTPSASY-LEVTPDSENDFGNYNCTAVNRIG-- 486
DG + Y +++ TP A VT E + + A N G
Sbjct: 17727 PKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786
Query: 487 QESLEFILVQADTPSSPSIDQVEP-----YSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
+ S ++A P P + P TA + + +P + GG PIL Y E + G
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
W+ + E + + GL Y R+ A N G GE
Sbjct: 17847 TAQWNR--INKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGE 17889
Score = 65.1 bits (157), Expect = 3e-10
Identities = 101/431 (23%), Positives = 167/431 (38%), Gaps = 60/431 (13%)
Query: 30 EISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANID 89
E+S ++ +C+V+ + + W+ + E + + I + L I NA+++
Sbjct: 12473 EVSETDTIKLVCEVSKPGAE--VIWYKGDEEIIETGRYEILT---EGRKRILVIQNAHLE 12527
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
DAG Y C + S VK+ + F + P E EGE A VC + P
Sbjct: 12528 DAGNYNCRLPS-----SRTDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP- 12581
Query: 149 IIWKHKGR--------DVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
+ WK + DVI R +V+ + LQ G G R +
Sbjct: 12582 VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAAAHLTV----- 12636
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDA--EGFPEPTMSWTKDGEQIEQEE 258
+ ++++V + T Q Q V C+ EG W ++ E I
Sbjct: 12637 IEKLRIVVPLKDTRVKEQ----------QEVVFNCEVNTEG---AKAKWFRNEEAIF--- 12680
Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
D KYI D L I+ +D+A Y N GE + + + + VE
Sbjct: 12681 DSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPL 12740
Query: 317 TAMELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
+E E+ VT C+ + + ++ W T+N EE D + R LT+K
Sbjct: 12741 KDIETMEKKSVTFWCKVNRLNV-TLKW---TKN--GEEVPFDNRVSYRVDKYKHMLTIKD 12794
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFAYP 432
+ D GEYI TA GQD L + AP ++ E + +C++ +
Sbjct: 12795 CGFPDEGEYIVTA----GQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQL-SRE 12849
Query: 433 SATISWFRDGQ 443
A + W+R+G+
Sbjct: 12850 KANVKWYRNGR 12860
Score = 64.7 bits (156), Expect = 3e-10
Identities = 74/331 (22%), Positives = 120/331 (36%), Gaps = 58/331 (17%)
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPT+ + + N T G+SVTL C G+P PT++W ++ QIE D + F +
Sbjct: 942 PPTLVS--GLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQ-ITFQSGIA 998
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
+L I++ D + C A N+AG + +L V Q + E E++ T
Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAV-----------QVSEEFEKETTAV-- 1045
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 390
T ++EEK +R +T S+ AG
Sbjct: 1046 --------------TEKFTTEEKRF-------VESRDVVMTDTSLTEEQAGP-------- 1076
Query: 391 IGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNY 450
G+ + ++ KL EG V C+V P + W + G L +
Sbjct: 1077 -GEPAAPYFITKPVVQKLV--------EGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYR 1127
Query: 451 SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE-FILVQADTPSSPSIDQVE 509
+ L ++ +D G Y N+ G+ S +L +AD Q
Sbjct: 1128 YKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEM 1187
Query: 510 PYSSTAQVQFDEP---EATGGVPILKYKAEW 537
Y + EP E G +Y+ E+
Sbjct: 1188 LYQTQVTAFVQEPKVGETAPGFVYSEYEKEY 1218
Score = 64.7 bits (156), Expect = 3e-10
Identities = 59/279 (21%), Positives = 115/279 (41%), Gaps = 14/279 (5%)
Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
++ +G + +T + P W ++GQ + I + + + L + D
Sbjct: 30146 IFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISK----RAMIATSETHTELVIKEADRGD 30201
Query: 474 FGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQFDEPEATGGVPIL 531
G Y+ N+ G++++ + +P+SP ++ + + +V + P GG IL
Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261
Query: 532 KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591
Y E R V + W++ + S+ + GLK Y R++A N G+ + +
Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGTSL----VVKGLKENVEYHFRVSAENQFGISKPLKSE 30317
Query: 592 EFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIR-HYLVRYRALSSEWK 647
E T P P D V+L +DDGGS + +Y+ R + +W
Sbjct: 30318 EPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWV 30377
Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
+ + + L +AEY+ ++A+N G S+ +
Sbjct: 30378 RHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETS 30416
Score = 63.9 bits (154), Expect = 6e-10
Identities = 114/554 (20%), Positives = 216/554 (38%), Gaps = 65/554 (11%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG 100
C+V+ KD + WF +GE++ P+ + + D L I A++ D G Y C G
Sbjct: 11684 CEVS---KDVPVKWFK-DGEEIVPSPKYS--IKADGLRRILKIKKADLKDKGEYVCDC-G 11736
Query: 101 EDGSESEATVNVKIF--QKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
D +++ TV ++ +K ++ E E + DV WK KG+ +
Sbjct: 11737 TDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDVHGQ------WKLKGQPL 11790
Query: 159 ILKKDVRFIVLSNNYLQIRG---IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQ 215
D I ++ I + T E +++ A + K++ +I P
Sbjct: 11791 TASPDCEIIEDGKKHILILHNCQLGMTGEVSFQAANAKSA-ANLKVKELPLIFITP---- 11845
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ-LTI 274
+ + C+ P+ T W K ++I DD + D + + I
Sbjct: 11846 ----LSDVKVFEKDEAKFECEVSREPK-TFRWLKGTQEITG--DDRFELIKDGTKHSMVI 11898
Query: 275 KKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGD 334
K DEA+Y+ AE+K + ++ +T +++ TA E +E T E S D
Sbjct: 11899 KSAAFEDEAKYMFEAEDK--HTSGKLIIEGIRLKFLTPLKDVTAKE-KESAVFTVELSHD 11955
Query: 335 PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD 394
I + W + + + + + ++ + S+T K + D + A +G
Sbjct: 11956 NI-RVKWFKNDQRLHTTRS-----VSMQDEGKTHSITFKDLSIDDTSQIRVEA---MGMS 12006
Query: 395 SQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI 453
S++ ++ P G + YT E ++V + CE+ + A + WF+DG+ + S + I
Sbjct: 12007 SEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGKEIKPSKNAVI 12065
Query: 454 KIYNTPSASYLEVTPDSENDFGNYNC-----TAVNRIGQESLEFILVQADTPSSPSIDQV 508
K L+ ++D G Y C ++ E E LV+ S++ +
Sbjct: 12066 KADGKKRMLILKKA--LKSDIGQYTCDCGTDKTSGKLDIEDREIKLVR----PLHSVEVM 12119
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568
E ++ + + E + A W+ GE + + + KE + + +
Sbjct: 12120 ETETARFETEISEDD---------IHANWKLKGEALLQTPDCEIKEEGKIHSLVLHNCRL 12170
Query: 569 ETTYAVRLAALNGK 582
+ T V A N K
Sbjct: 12171 DQTGGVDFQAANVK 12184
Score = 63.9 bits (154), Expect = 6e-10
Identities = 106/496 (21%), Positives = 176/496 (35%), Gaps = 58/496 (11%)
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD- 278
+ T G + L G PEP ++WTK ++Q D++ + + T+ VD
Sbjct: 13697 LAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQ---DKRITIENVPKKSTVTIVDS 13753
Query: 279 -KNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIP 337
++D YI A N G A + + V KP A ++ + +C + +P P
Sbjct: 13754 KRSDTGTYIIEAVNVCGRATAVVEVNVLDKP-----GPPAAFDITDVTNESCLLTWNP-P 13807
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNT--IGQ 393
+ N E + D + + + V K+ + EYI A N +G+
Sbjct: 13808 RDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYGVGE 13867
Query: 394 DSQSMYLEVQYAPKLQGP------------VAVYTW-----EGNQVNITCEVFAYPSATI 436
Q+ + +Y GP TW +G V T
Sbjct: 13868 PVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTD 13927
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQ 496
W R ++ +K V ++ G +S E IL++
Sbjct: 13928 KWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGK---------PSKSTEPILIK 13978
Query: 497 --ADTPSSPSIDQVEPYSSTA-QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D P P V+ T+ ++ + +PE GG I Y E G + W
Sbjct: 13979 DPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEW-------- 14030
Query: 554 EASMEGIVT----IVGLKPETTYAVRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKLE 608
EG+ T + GL Y+ R+ A+N G E S S+ + PS P+
Sbjct: 14031 VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWL 14090
Query: 609 GQMGEDGNSIKVN-LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWN 667
+ N+ + + + DGGSPI +Y+V R + + + + L
Sbjct: 14091 EVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEG 14150
Query: 668 AEYEVYVVAENQQGKS 683
+ Y V AEN G+S
Sbjct: 14151 SLYVFRVAAENAIGQS 14166
Score = 63.5 bits (153), Expect = 8e-10
Identities = 92/389 (23%), Positives = 154/389 (39%), Gaps = 52/389 (13%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L +G P P+ +W + + E+ + V +H +V+ LT++ D GEY
Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESER-----VTVETHTKVAKLTIRETTIRDTGEYT 29810
Query: 385 CTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FR 440
N G S+++ + + P GP+ + ++++ T S TISW
Sbjct: 29811 LELKNVTGTTSETIKVIILDKPGPPTGPIKI-----DEIDAT-------SITISWEPPEL 29858
Query: 441 DGQLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES- 489
DG P S Y + + + + S + T +E + + A NR G S
Sbjct: 29859 DGG-APLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSY 29917
Query: 490 LEFILVQADT----PSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEV 544
L+ +++ + P P Q+ S + + PE GG + Y E +EV
Sbjct: 29918 LQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVE----RKEV 29973
Query: 545 WHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603
+W + + GL Y R+ A+N +G G+ S S+ V +P
Sbjct: 29974 RADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSK---PIVAMDPI 30030
Query: 604 AP--KLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRALSS-EWKPEIRLPSGSD 657
AP K + D V+L + +D+GGS + YL+ + + EW P+
Sbjct: 30031 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 30090
Query: 658 HVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
L L AEY V+A N G + A
Sbjct: 30091 EYTLTHLPQGAEYRFRVLACNAGGPGEPA 30119
Score = 62.8 bits (151), Expect = 1e-09
Identities = 95/440 (21%), Positives = 166/440 (37%), Gaps = 49/440 (11%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDA-TIHLKVFAK-----PKITYVENQTAMELE 322
S Q I + + +E + +A N+ G D ++ + + AK P + + ++++
Sbjct: 23185 SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVG 23244
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
+ + + SG P P+ITW + + + V +++L++K D G+
Sbjct: 23245 QDLKIEVPISGRPKPTITWTKDGLPLKQTTR-----INVTDSLDLTTLSIKETHKDDGGQ 23299
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y T +N +GQ + S+ + P +GPV + ++ P +
Sbjct: 23300 YGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWN----PPLYTGGCQI 23355
Query: 442 GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIGQE-SLEFILVQ 496
+ + +++ SA+ L+VT + A NR GQ +LE +
Sbjct: 23356 TNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIV 23415
Query: 497 ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAE--------WRAVGEE 543
A P P+++ +Q+ EP GG P++ Y E W V +
Sbjct: 23416 AQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKT 23475
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603
+ H + A+ EGI Y R+ A N G+G+ S SE +P
Sbjct: 23476 IIHDTQFKAQNLE-EGI----------EYEFRVYAENIVGVGKASKNSECYVARDPCDP- 23523
Query: 604 APKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRAL-SSEWKPEIRLPSGSDHVML 661
P + N I + K DGGS I Y+V R L W +
Sbjct: 23524 -PGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTV 23582
Query: 662 KSLDWNAEYEVYVVAENQQG 681
L + YE V+A+N G
Sbjct: 23583 SGLTEDQRYEFRVIAKNAAG 23602
Score = 62.8 bits (151), Expect = 1e-09
Identities = 81/342 (23%), Positives = 136/342 (39%), Gaps = 57/342 (16%)
Query: 271 QLTIKKVDKNDEAEY-ICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
Q T+ K+ +N E + IC ++ + AT+ V A+ +I E + +L + V L
Sbjct: 25062 QFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRA 25121
Query: 330 EAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS----LTLKSIQY 377
A+ G P P + W + +G + R+ V+S L + ++
Sbjct: 25122 SATLRLFVTIKGRPEPEVKWEKA-----------EGILTDRAQIEVTSSFTMLVIDNVTR 25170
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
D+G Y T N G S++ ++ V+ PV N+T S T+S
Sbjct: 25171 FDSGRYNLTLENNSG--SKTAFVNVRVLDSPSAPV----------NLTIREVKKDSVTLS 25218
Query: 438 W---FRDG-----QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN----YNCTAVNRI 485
W DG + + K Y T + + + T EN + A N
Sbjct: 25219 WEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEY 25278
Query: 486 G----QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
G E+ E + V + V+ +TA +++++PE+ GG I Y E + G
Sbjct: 25279 GIGLPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKG 25338
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
E W + + ++E TI GL Y R+AA+N KG
Sbjct: 25339 SEKWST---CTQVKTLE--ATISGLTAGEEYVFRVAAVNEKG 25375
Score = 62.4 bits (150), Expect = 2e-09
Identities = 101/460 (21%), Positives = 180/460 (39%), Gaps = 63/460 (13%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---------KPKITYVENQTAM 319
++ ++ +D++ E+ A N+ GE + ++ L V K +++ + +
Sbjct: 15351 TTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKV 15410
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV-----RSHARVSSLTLKS 374
+ E V + + +G P+P I W ++N + EK D + RS A+ K+
Sbjct: 15411 KAGEPVHIPADVTGLPMPKIEW---SKNETVIEKPTDALQITKEEVSRSEAKTELSIPKA 15467
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV---------YTWEGNQVNIT 425
++ D G Y TASN +G +++++EV P +AV TW+ N
Sbjct: 15468 VR-EDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGG 15526
Query: 426 CEVFAY-------PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NY 477
E+ Y W Y K+ P+ Y E + N +G +
Sbjct: 15527 SEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKL--IPNGQY-EFRVRAVNKYGISD 15583
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
C + + Q+ P P + + + V + P GG PI Y E
Sbjct: 15584 ECKSDKVVIQDPYRL----PGPPGKPKV--LARTKGSMLVSWTPPLDNGGSPITGYWLEK 15637
Query: 538 RAVGEEVW-HSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAAS--EF 593
R G W + ++G+ + L Y R A+N G+G S S E
Sbjct: 15638 REEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEV 15697
Query: 594 KTQPV--QGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLVRYRAL-SSEWK 647
P+ G PS P++ +D ++L DGGSPI+ Y+V + +++WK
Sbjct: 15698 AGDPIFPPGPPSCPEV-----KDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWK 15752
Query: 648 PEIRLPS---GSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
+ P + ++ +L +Y V A N+ G+S+
Sbjct: 15753 -RVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESE 15791
Score = 62.0 bits (149), Expect = 2e-09
Identities = 97/415 (23%), Positives = 163/415 (39%), Gaps = 66/415 (15%)
Query: 24 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTI 83
+ P + GE+ F C+V G + K ++W+ NG+ L +R V + D L I
Sbjct: 1845 LYPEPVRVLEGETARFRCRVTGYPQPK-VNWYL-NGQ-LIRKSKRFRVRY--DGIHYLDI 1899
Query: 84 YNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKN----APTPQ-EFREGEDAVIV 138
+ D G K +G E V ++I Q+ F++ AP P+ EF E +
Sbjct: 1900 VDCKSYDTGEVKVTAENPEGV-IEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQ 1958
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRF----IVLSNNYLQIRGIKKTDEGTYRC----- 189
+V P + K V LK+ R + + L+ + ++T+EG Y
Sbjct: 1959 FEVQKVDRPVDTTETK-EVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVE 2017
Query: 190 -------------------------------EGRILAR-GEINFKDIQVI-VNVPPTIQA 216
E + LA G+I + + + P+++A
Sbjct: 2018 LKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEA 2077
Query: 217 R---QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
+ I + T G G P+P W K+G +IE+ + Y D+ +L
Sbjct: 2078 PKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELV 2137
Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY---VENQTAMELEEQVTLTCE 330
I+ V D A + A N AGE + L V AK IT+ +++ A E + T CE
Sbjct: 2138 IRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECE 2197
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
S +P + W + +K + S +V L++ +I +DA +Y C
Sbjct: 2198 TS-EPFVKVKWYKDGMEVHEGDK-----YRMHSDRKVHFLSILTIDTSDAEDYSC 2246
Score = 61.6 bits (148), Expect = 3e-09
Identities = 97/392 (24%), Positives = 157/392 (40%), Gaps = 61/392 (15%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E + + + +G P+P I+W I EE+ + +H + LT+K D G+
Sbjct: 25805 EVLKINADIAGRPLPVISWAKD--GIEIEERARTEIISTDNH---TLLTVKDCIRRDTGQ 25859
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR- 440
Y+ T N G S ++ +V P GP+ + +T E ++SW R
Sbjct: 25860 YVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN-------GLTAE-----KCSLSWGRP 25907
Query: 441 --DGQLLPSSNYSNIKIYNTPSASYL-----------EVTPDSENDFGNYNCTAVNRIGQ 487
DG +Y ++ T ++ +VT + + + T VN+ G
Sbjct: 25908 QEDGGA--DIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGV 25965
Query: 488 -ESLEFILVQA----DTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
E LE + ++A PS P S++ + + + PE+ GG I Y E R
Sbjct: 25966 GEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKN 26025
Query: 542 EEVW----HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF--KT 595
W YD + S GL+ Y R+ A N GL S S
Sbjct: 26026 SLRWVRVNKKPVYDLRVKS-------TGLREGCEYEYRVYAENAAGLSLPSETSPLIRAE 26078
Query: 596 QPV--QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRY-RALSSEWKPEIR 651
PV PS PK+ + +I + +K DGG+PI Y V Y ++ ++WK I+
Sbjct: 26079 DPVFLPSPPSKPKI---VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQ 26135
Query: 652 LPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
G+++ + L AEY V + N+ G S
Sbjct: 26136 SLRGTEYT-ISGLTTGAEYVFRVKSVNKVGAS 26166
Score = 61.2 bits (147), Expect = 4e-09
Identities = 50/180 (27%), Positives = 81/180 (45%), Gaps = 9/180 (5%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE-DDEKYIFSDDSSQLTIKKVDKNDEAEYI 286
G + T GFP P +SW +DG+ I + FSD ++LTI V K + Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79
Query: 287 CIAENKAGEQDATIHLKVFAK-PKITYVENQTAMELEE--QVTLTCEASGDPIPSITWRT 343
A N +G+ +T L V A+ +V+ +M + + QV L +G P P + +
Sbjct: 80 LKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYR 139
Query: 344 STRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
I S +LD + + SL + D+G Y A+N++G+ + + L VQ
Sbjct: 140 DGAEIQS---SLD--FQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQ 194
Score = 61.2 bits (147), Expect = 4e-09
Identities = 124/583 (21%), Positives = 233/583 (39%), Gaps = 79/583 (13%)
Query: 39 FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVV 98
F CQ++ + + + W+ NG ++ ++ D S L I + +DD Y C
Sbjct: 12842 FSCQLSREKAN--VKWYR-NGREIKEGKKY--KFEKDGSIHRLIIKDCRLDDECEYAC-- 12894
Query: 99 TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDV 158
G + +S A + V +++ + PQ+ E A +V + + + V
Sbjct: 12895 -GVEDRKSRARLFV---EEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQWLRNNMV 12950
Query: 159 ILKKDVRFIVLSNNY--LQIRGIKKTDEGTYRCEGRIL-ARGEINFKDIQVIVNVPPTIQ 215
+++ D ++ LQI IK D+G YR + AR ++ + P
Sbjct: 12951 VVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLE------LAAAPKIKT 13004
Query: 216 ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK 275
A Q++V ++G+ +T+V + +P+ W K+ E + + D + + + I
Sbjct: 13005 ADQDLV---VDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDT----TAEQTSFRIL 13057
Query: 276 KVDKNDEAEYICIAENKAGEQDATIHLKVFAKP------KITYV-ENQTAMELEEQVTLT 328
+ K D+ Y + +NK G+ + I+LKV P ++T + + ++ EE +T
Sbjct: 13058 EAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPVRNLEVTETFDGEVSLAWEEPLT-- 13115
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTAS 388
G I I + R+I + L V+ L ++Y + +A
Sbjct: 13116 --DGGSKI--IGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYL----FRVSAR 13167
Query: 389 NTIGQ----------DSQSMY------LEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP 432
N +G +++S Y L V + V++ TWE + + E+ Y
Sbjct: 13168 NRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSL-TWEPPEYDGGAEITNY- 13225
Query: 433 SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488
+ RD + ++ + SA+ +V E F A NRIG
Sbjct: 13226 ---VIELRDKTSIRWDTAMTVRAEDL-SATVTDVVEGQEYSF---RVRAQNRIGVGKPSA 13278
Query: 489 SLEFILVQ--ADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545
+ F+ V + PS P ++ + S+ Q++++ P GG PIL Y E G++ W
Sbjct: 13279 ATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNW 13338
Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
+ E + GL+ Y R++A N G+ + S
Sbjct: 13339 IR---CNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVSDPS 13378
Score = 61.2 bits (147), Expect = 4e-09
Identities = 113/473 (23%), Positives = 182/473 (38%), Gaps = 53/473 (11%)
Query: 273 TIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKITYVENQTAMELE--EQVTL 327
T K +++ E ++ AEN AG + AT K V +T++E++ +++ L
Sbjct: 14640 TAKGLEEGKEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIAL 14699
Query: 328 TCEASGDPIPSITWRTSTRNISSEE-KTLDGHMVVRSHARVSS-------LTLK-SIQYT 378
SG P P+ITW I EE K +V R V LT + SI +
Sbjct: 14700 DASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNS 14759
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQY---APKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
GE +++ D ++V+ K V+V G +N E S
Sbjct: 14760 KKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVLDTPGPPINFVFEDIRKTSVL 14819
Query: 436 ISW---FRDG-------------QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
W DG + P S + I + +T VT E +
Sbjct: 14820 CKWEPPLDDGGSEIINYTLEKKDKTKPDSEW--IVVTSTLRHCKYSVTKLIEGKEYLFRV 14877
Query: 480 TAVNRI--GQESLEFILVQAD---TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKY 533
A NR G + LV D P +P VE +S + V+++EP+ G PIL Y
Sbjct: 14878 RAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGS-PILGY 14936
Query: 534 KAEWRAVGEEVW---HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAA 590
E R V W + +A +A+++G+ + GL TY R+ A N G G+ S
Sbjct: 14937 WLEKREVNSTHWSRVNKSLLNALKANVDGL--LEGL----TYVFRVCAENAAGPGKFSPP 14990
Query: 591 SEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ--DDGGSPIRHYLVRYRALSSEWKP 648
S+ KT P P + +I++ + GG + +++ + ++EW
Sbjct: 14991 SDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSR 15050
Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPA 701
+K + A+Y++ V A N G+ T A+P PA
Sbjct: 15051 CTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPA 15103
Score = 60.8 bits (146), Expect = 5e-09
Identities = 137/625 (21%), Positives = 229/625 (36%), Gaps = 92/625 (14%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE C V G + I W G ++ P+ R S + ++ L + + D
Sbjct: 8357 VSEGEYVQLSCHVQGSEPIR-IQWLKA-GREIKPSD-RCSFSFAS-GTAVLELRDVAKAD 8412
Query: 91 AGIYKCV---VTGEDGSESEATVNVK-----------IFQKLMFKNAPTPQEFREGEDAV 136
+G Y C V G D ++S+ T+ K + +L F + P E A
Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472
Query: 137 IVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN---YLQIRGIKKTDEGTYRCEGRI 193
+ V P + W KG+ L + R + L+IR KTD G YRC
Sbjct: 8473 FIAKVGGDPIPNVKWT-KGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVA-F 8530
Query: 194 LARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT---MSWTKD 250
GEI VN+ + +Q + T + E M K+
Sbjct: 8531 NEHGEIESN-----VNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKN 8585
Query: 251 GEQIEQEEDDEKYIFSDDSSQLT---IKKVDKNDEAEYICIAENKAGEQD--------AT 299
+ E E+ Y +D L + K + +E + I E + E+D +
Sbjct: 8586 VDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSF 8645
Query: 300 IHLKVFAKPKITYV---ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--- 353
I ++ +T + ENQT ++ + V P ++W T + +K
Sbjct: 8646 IQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEI 8705
Query: 354 TLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA 413
++DG +L +K+ Q D G Y I ++ +E + LQ
Sbjct: 8706 SIDGDR--------HTLRVKNCQLKDQGNYRLVCGPHIASAKLTV-IEPAWERHLQD--- 8753
Query: 414 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
V EG +TC+ F+ P+ WFR+G++L ++ + L + D
Sbjct: 8754 VTLKEGQTCTMTCQ-FSVPNVKSEWFRNGRILKPQGRHKTEVEH--KVHKLTIADVRAED 8810
Query: 474 FGNYNC-------TAVNRIGQESLEFILVQADTPSSPSIDQVEPYSST--AQVQFDEPEA 524
G Y C +A RI E ++F T +I E S+T +V FD+
Sbjct: 8811 QGQYTCKYEDLETSAELRIEAEPIQF------TKRIQNIVVSEHQSATFECEVSFDDAIV 8864
Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP--ETTYAVRLAALNGK 582
T W E+ S+ Y+ + +TI + P E Y+V +A L +
Sbjct: 8865 T-----------WYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSV-IARLEPR 8912
Query: 583 GLGEISAASEFKTQPVQGEPSAPKL 607
G +A T+ ++ E P +
Sbjct: 8913 GEARSTAELYLTTKEIKLELKPPDI 8937
Score = 60.8 bits (146), Expect = 5e-09
Identities = 65/266 (24%), Positives = 105/266 (39%), Gaps = 12/266 (4%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G+ + ++ + P ++W ++ + P+ +I TP S LE+ + D G Y+
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTK----ARIDVTPVGSKLEIRNAAHEDGGIYS 17288
Query: 479 CTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
T N G +++ ++ D P P ++ E + + + EP GG I Y E
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVER 17348
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596
R V W +K+ S L Y R+AA N G G + K
Sbjct: 17349 RDVASAQWSPLSATSKKKSH----FAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKAL 17404
Query: 597 PVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSG 655
P PK + D + + K D DGGSPI YLV Y+ ++ + + +
Sbjct: 17405 DPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTN 17464
Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQG 681
+ V + L Y V AEN G
Sbjct: 17465 LECV-VTGLQQGKTYRFRVKAENIVG 17489
Score = 60.1 bits (144), Expect = 9e-09
Identities = 95/425 (22%), Positives = 158/425 (37%), Gaps = 48/425 (11%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L G P+P+++W+ + E + + + +L L S+ D+G+Y
Sbjct: 19313 VCLDATVFGKPMPTVSWKKDGTLLKPAEG-----IKMAMQRNLCTLELFSVNRKDSGDYT 19367
Query: 385 CTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY---- 431
TA N+ G S ++ L+V P K+ A+ +WE + E+ Y
Sbjct: 19368 ITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDK 19427
Query: 432 -PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
++ +W + +P ++ S K+ E + A N+ G
Sbjct: 19428 RETSRPNWAQVSATVPITSCSVEKLI--------------EGHEYQFRICAENKYGVGDP 19473
Query: 491 EFILVQ-ADTPSSPSIDQVEPYSSTAQ-----VQFDEPEATGGVPILKYKAEWRAVGEEV 544
F A P P P S V + P GG PI Y E R
Sbjct: 19474 VFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVN 19533
Query: 545 WHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK-TQPVQGEPS 603
W ++ +E + GL+ T Y R+ A+N G G+ S AS+ + Q P
Sbjct: 19534 WTKV---NRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPG 19590
Query: 604 APKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLK 662
P +S+ ++ K DGGSPI YLV + S+ LP +
Sbjct: 19591 PPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFE 19650
Query: 663 --SLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV--GIL 718
L + +Y+ V A N+ G S + + + IP G + L I+ G+
Sbjct: 19651 VTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVT 19710
Query: 719 IVIFV 723
+ ++V
Sbjct: 19711 MRLYV 19715
Score = 60.1 bits (144), Expect = 9e-09
Identities = 83/356 (23%), Positives = 135/356 (37%), Gaps = 49/356 (13%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLT 328
++ I K+ ++ E + A NK G +AT + V + K+ E EL + + +
Sbjct: 23978 TRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVR 24037
Query: 329 CEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
S G P P ITW S EE + + + L++ + DA
Sbjct: 24038 AGGSARIHIPFKGRPTPEITW-------SREEGEFTDKVQIEKGVNYTQLSIDNCDRNDA 24090
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAP---------KLQGPVAVYTWEGNQVNITCEVFAY 431
G+YI N+ G S + ++V P +++ A WE ++ +V Y
Sbjct: 24091 GKYILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNY 24150
Query: 432 PSATISWFRDGQLLPSSNYS--NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
R SS S + K+ N + +EN+FG +G
Sbjct: 24151 VIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFG---------VGVPV 24201
Query: 490 LEFILVQADTPSSP--SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
V+A P SP + + ++A + +++PE GG +L Y E + G E
Sbjct: 24202 ETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTE---- 24257
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKG------LGEISAASEFKTQP 597
KW E+ + V + GL Y R+ A N KG LG A + QP
Sbjct: 24258 KWSIVAESKVCNAV-VTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQP 24312
Score = 59.7 bits (143), Expect = 1e-08
Identities = 93/363 (25%), Positives = 137/363 (37%), Gaps = 69/363 (19%)
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARV 367
PKI E Q ++ +++ + G P P+ W+ +E H+ V
Sbjct: 18900 PKILMPE-QITIKAGKKLRIEAHVYGKPHPTCKWKKG-----EDEVVTSSHLAVHKADSS 18953
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTW 417
S L +K + D+G Y TA N+ G D+Q + + V AP + +W
Sbjct: 18954 SILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSW 19013
Query: 418 ----EGNQVNIT------CE------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA 461
E NIT C+ V A S T + R G+L+P Y I+
Sbjct: 19014 HIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEY----IFRV--- 19066
Query: 462 SYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQF 519
+EN FG + T+ + Q PS P +V + V +
Sbjct: 19067 -------RAENRFGISEPLTSPKMVAQ-------FPFGVPSEPKNARVTKVNKDCIFVAW 19112
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
D P++ GG PI+ Y E + +W K D S E GL Y+ R+ AL
Sbjct: 19113 DRPDSDGGSPIIGYLIERKERNSLLW-VKANDTLVRSTE--YPCAGLVEGLEYSFRIYAL 19169
Query: 580 NGKGLGEISAASEFKT--QPVQGEPSAPKLEGQMGEDGNSIKVNLI---KQDDGGSPIRH 634
N G S +E+ T PV P P++ D V+LI + DGGS I
Sbjct: 19170 NKAGSSPPSKPTEYVTARMPVD-PPGKPEV-----IDVTKSTVSLIWARPKHDGGSKIIG 19223
Query: 635 YLV 637
Y V
Sbjct: 19224 YFV 19226
Score = 59.3 bits (142), Expect = 1e-08
Identities = 104/493 (21%), Positives = 195/493 (39%), Gaps = 59/493 (11%)
Query: 168 VLSNNYLQIRGIKKTDEGTYRCEG-RILARGEINFKDIQVIVN---VPPTIQA--RQNIV 221
+LS Y ++G+K+ D YR I+ +G+ +F + PPT+ R +
Sbjct: 16771 LLSRKYT-VKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKL- 16828
Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIK-KVDKN 280
T +G++ L G P+P +SW KD + + EDD +I + ++ K K ++
Sbjct: 16829 --TIRVGEAFALTGRYSGKPKPKVSWFKD--EADVLEDDRTHIKTTPATLALEKIKAKRS 16884
Query: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340
D +Y + EN G + + V +P ++ + ++ + P+
Sbjct: 16885 DSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKP---PLDDGG 16941
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICT--ASNTIGQDSQSM 398
+ + I +E D M V S + + T K + + +YI A N G +
Sbjct: 16942 SKITNYIIEKKEVGKDVWMPVTSAS--AKTTCKVSKLLEGKDYIFRIHAENLYGISDPLV 16999
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--DGQLLPSSNYSNIKIY 456
++ + + P + I EV SA ++W + DG P +NY ++
Sbjct: 17000 SDSMKAKDRFRVP------DAPDQPIVTEV-TKDSALVTWNKPHDGGK-PITNYI-LEKR 17050
Query: 457 NTPSASYLEVTPDSENDFGNYN-------CTAVNRIGQESLEFILVQADTPSSPSI---- 505
T S + VT D + + + C R+ E+ E + PS P
Sbjct: 17051 ETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAEN-EIGIGDPSPPSKPVFAKDP 17109
Query: 506 ----------DQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+ ++ ++ + + P GG IL Y E++ VG+E W + E+
Sbjct: 17110 IAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWR-RANHTPES 17168
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED- 614
E + GL+ TY R+ A+N G + + E + EP L+ M +
Sbjct: 17169 CPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQ 17228
Query: 615 ----GNSIKVNLI 623
G++++++ I
Sbjct: 17229 HIKVGDTLRLSAI 17241
Score = 59.3 bits (142), Expect = 1e-08
Identities = 103/461 (22%), Positives = 178/461 (38%), Gaps = 58/461 (12%)
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE---QDATI---------HLKV 304
EE+ + + S Q + K + + E + AEN+ GE + T+ L +
Sbjct: 19925 EENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDL 19984
Query: 305 FAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH 364
P + Y+ + + L G P PS++W+ +++ D + V S
Sbjct: 19985 KGLPDLCYLAKENS-----NFRLKIPIKGKPAPSVSWKKGEDPLAT-----DTRVSVESS 20034
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVN 423
A ++L + Q +DAG+Y T N G ++ ++V P + GP+ +
Sbjct: 20035 AVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMT 20094
Query: 424 ITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA---SYLEVTPDSENDFGNYNCT 480
+ +A P +L + N K SA + VT E + +
Sbjct: 20095 LK---WAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVS 20151
Query: 481 AVNRIGQ-ESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILK 532
A N+ G E L+ + A D P P+I V+ + + + +P+ TGG PI
Sbjct: 20152 AENKYGVGEGLKSEPIVARHPFDVPDAPPPPNI--VDVRHDSVSLTWTDPKKTGGSPITG 20209
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGI----VTIVGLKPETTYAVRLAALNGKGLGEIS 588
Y E++ +W K A+ I + GL Y R+ A+N G+G+ S
Sbjct: 20210 YHLEFKERNSLLW-------KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS 20262
Query: 589 AASE--FKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRAL-SS 644
SE P+ P P++ + NS+ + + + DGG + Y+V R L S
Sbjct: 20263 LPSEPVVALDPID-PPGKPEV---INITRNSVTLIWTEPKYDGGHKLTGYIVEKRDLPSK 20318
Query: 645 EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
W + + L +YE + A+N G A
Sbjct: 20319 SWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISA 20359
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/399 (21%), Positives = 157/399 (39%), Gaps = 34/399 (8%)
Query: 209 NVPPTIQARQNIVNATA-NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
NVPP ++ + G+S+ + +G P P ++W KDG +IE+ + E +D
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNME---ITD 28009
Query: 268 --DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQV 325
S+ L ++ ++ Y A+N +G A I +KV P + E++
Sbjct: 28010 VLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKM 28069
Query: 326 TLTCEAS-GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
TL +A D IT I E + ++ S T + + ++
Sbjct: 28070 TLWWDAPLNDGCAPITHYI----IEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFR 28125
Query: 385 CTASNTIG----QDSQSMYLEVQY-APKLQGPVAVYTWEGNQVNITCEVFAYP-----SA 434
+A N G DS + ++QY P G GN + +T +A P S
Sbjct: 28126 VSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLT---WARPESDGGSE 28182
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI- 493
+ + + S+ + + S + +VT +E + ++ A N G I
Sbjct: 28183 IQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGIS 28242
Query: 494 -LVQADTPSSPS-----IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
L++ P +P + + +T +++ +P GG+ I+ Y E WH
Sbjct: 28243 RLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHK 28302
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
EA ++ T+ L+ Y R++A+NG G G+
Sbjct: 28303 V---NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGD 28338
Score = 58.9 bits (141), Expect = 2e-08
Identities = 83/339 (24%), Positives = 133/339 (39%), Gaps = 52/339 (15%)
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P+P +W + ++I + T + S S LT+K DAGEY TA+N G
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQ-----ITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSN 449
+ + + V P GPV + N++ E AT++W DG P +
Sbjct: 20460 TKVEHVKVTVLDVPGPPGPVEI-------SNVSAE-----KATLTWTPPLEDGG-SPIKS 20506
Query: 450 YSNIKIYNTPSASYLEVTPDSEN--------DFGN---YNCTAVNRIGQ------ESLEF 492
Y ++ T + V+ D ++ GN + +AVN G+ E ++
Sbjct: 20507 YI-LEKRETSRLLWTVVSEDIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKM 20565
Query: 493 I--LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
+ P P + V +TA V + P GG I Y E R E +W
Sbjct: 20566 VDRFGPPGPPEKPEVSNVT--KNTATVSWKRPVDDGGSEITGYHVERR----EKKSLRWV 20619
Query: 551 DAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEG 609
A + + + + GL+ +TY R++A N G+G S AS+ P P
Sbjct: 20620 RAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNP 20679
Query: 610 QMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSSE 645
+ D +L DGG I Y+V ++ + E
Sbjct: 20680 HV-TDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717
Score = 58.5 bits (140), Expect = 2e-08
Identities = 70/334 (20%), Positives = 122/334 (36%), Gaps = 65/334 (19%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
GQ+ G P P W DG+QI + + I D + L I +D E+
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 288 IAENKAGEQDATIHLKVFA---KPKITYVENQTAMELEE--QVTLTCEASGDPIPSITWR 342
+A+N+AG ++ L V A + K +VE + ++E ++ + A+G+P P I W
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQ--SMYL 400
++ I + + + ++L + S D+ Y TA N G+D+ + +
Sbjct: 1591 KNSDIIVPHKYP---KIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Query: 401 EVQYAP-----KLQGPVAVY--------------------TWEGNQV------------- 422
EV++A KL P Y WE +
Sbjct: 1648 EVEFAEPEPERKLIIPRGTYRAKEIAAPELEPLHLRYGQEQWEEGDLYDKEKQQKPFFKK 1707
Query: 423 -------------NITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
+ C + P+ + W DG+ L ++N +++ N L+
Sbjct: 1708 KLTSLRLKRFGPAHFECRLTPIGDPTMVVEWLHDGKPLEAAN--RLRMINEFGYCSLDYG 1765
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPS 501
D G C A N+ G + L+ D S
Sbjct: 1766 VAYSRDSGIITCRATNKYGTDHTSATLIVKDEKS 1799
Score = 58.5 bits (140), Expect = 2e-08
Identities = 78/300 (26%), Positives = 120/300 (40%), Gaps = 25/300 (8%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + + V P I+W + G L S I T S S L V + D G Y
Sbjct: 29461 GASLRLMVSVSGRPPPVITWSKQGIDLASRAI----IDTTESYSLLIVDKVNRYDAGKYT 29516
Query: 479 CTAVNRIGQESLEFILVQADTPS-SPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
A N+ G++S ++ DTP PS+ E + + ++ P GG P+ Y E
Sbjct: 29517 IEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEK 29576
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
R + + + + I GL T Y R+ N G+GE S+
Sbjct: 29577 REAAMRAFKT----VTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSD--AVL 29630
Query: 598 VQGEPSAP-KLEGQMGEDGNSIKVNLIKQD---DGGSPIRHYLVR-YRALSSEWKPEIRL 652
V P P KLE D V L + DGGS + Y++ +A + W + L
Sbjct: 29631 VSEVPLVPAKLE---VVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTL 29687
Query: 653 -PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 711
P+ +H + SL+ +Y + A+N++G S+ V + Q + PT LST
Sbjct: 29688 KPTVLEHT-VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV----LPTIDLST 29742
Score = 58.2 bits (139), Expect = 3e-08
Identities = 97/393 (24%), Positives = 162/393 (41%), Gaps = 55/393 (13%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E + + G PIP+I W + +S+ + + ++S +SL++K D+G
Sbjct: 22559 ESFKVDADIYGKPIPTIQWIKGDQELSNTAR-----LEIKSTDFATSLSVKDAVRVDSGN 22613
Query: 383 YICTASNTIGQDSQSMYLEVQYAP-KLQGPVAVYTWEGNQVNITCEVFAYPSATISW--- 438
YI A N G+ S ++ ++V P +GPV + +T E T++W
Sbjct: 22614 YILKAKNVAGERSVTVNVKVLDRPGPPEGPVVI-------SGVTAE-----KCTLAWKPP 22661
Query: 439 FRDG-----QLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVNRIG-QE 488
+DG + ++ ++ A+ +VT E + + AVN+ G E
Sbjct: 22662 LQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGE 22721
Query: 489 SLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
LE V A D P +P + V S V ++ P + GG IL Y E R
Sbjct: 22722 PLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMI--VVWERPASDGGSEILGYVLEKRDKE 22779
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK--TQPV- 598
W K E + + GL Y R++A N GL E S S ++ P+
Sbjct: 22780 GIRWTR---CHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIY 22836
Query: 599 -QGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALS-SEWKPEIRLPSG 655
G P+ PK+ + +S+ ++ K DGG I+ Y+V +S EW P+G
Sbjct: 22837 KPGPPNNPKV---IDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEW-TMCTPPTG 22892
Query: 656 --SDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 686
++ ++ L EY + A N+ G + A
Sbjct: 22893 INKTNIEVEKLLEKHEYNFRICAINKAGVGEHA 22925
Score = 57.8 bits (138), Expect = 4e-08
Identities = 87/402 (21%), Positives = 152/402 (37%), Gaps = 40/402 (9%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ + +D G Y V+ DG ++ + +K + + + Q+ EG+ ++ +
Sbjct: 2323 LTVKDVTKEDQGEYSFVI---DGKKTTCKLKMKP-RPIAILQGLSDQKVCEGD--IVQLE 2376
Query: 141 VVSSLPPTI-IWKHKGRDVILKKDVRFIVLSNNY-LQIRGIKKTDEGTYRCEGRILA--- 195
V SL +W G++V V ++ ++ L I + K D G Y L
Sbjct: 2377 VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLST 2436
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G ++ + VI + N++ T L C ++ W + EQI+
Sbjct: 2437 SGRVSVYSVDVITPLKDV-----NVIEGT-----KAVLECKVSVPDVTSVKWYLNDEQIK 2486
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ D + I +L I + +DE Y I G + +L V I + +
Sbjct: 2487 PD-DRVQAIVKGTKQRLVINRTHASDEGPYKLIV----GRVETNCNLSVEKIKIIRGLRD 2541
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
T E + V E S I + W + I K + +H ++ LT+ ++
Sbjct: 2542 LTCTETQN-VVFEVELSHSGI-DVLWNFKDKEIKPSSK-----YKIEAHGKIYKLTVLNM 2594
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
D G+Y A + ++ P VA E + CEV A P +
Sbjct: 2595 MKDDEGKYTFYAGENMTSGKLTVAGGAISKPLTDQTVA----ESQEAVFECEV-ANPDSK 2649
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
W RDG+ LP +N NI+ + L + +D G Y
Sbjct: 2650 GEWLRDGKHLPLTN--NIRSESDGHKRRLIIAATKLDDIGEY 2689
Score = 57.8 bits (138), Expect = 4e-08
Identities = 98/463 (21%), Positives = 195/463 (42%), Gaps = 64/463 (13%)
Query: 35 ESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSS-TLTIYNANIDDAGI 93
ES F +++ D + + WF N ++L + SV D+ + ++T + +IDD
Sbjct: 11944 ESAVFTVELSHD--NIRVKWFK-NDQRLHTTR---SVSMQDEGKTHSITFKDLSIDDTSQ 11997
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
+ G SE++ TV + F E ++ ++ C++ + P + W
Sbjct: 11998 IRVEAMGMS-SEAKLTV---LEGDPYFTGKLQDYTGVEKDEVILQCEISKADAP-VKWFK 12052
Query: 154 KGRDV------ILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-GRILARGEINFKDIQV 206
G+++ ++K D + L ++ K+D G Y C+ G G+++ +D ++
Sbjct: 12053 DGKEIKPSKNAVIKADGK-----KRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREI 12107
Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE-KYIF 265
+ P + + + + TA ++ + +W GE + Q D E K
Sbjct: 12108 KLVRP--LHSVEVMETETARFETEISE-------DDIHANWKLKGEALLQTPDCEIKEEG 12158
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN---QTAMELE 322
S L ++D+ ++ +A ++ HL+V KP++ + +
Sbjct: 12159 KIHSLVLHNCRLDQTGGVDF------QAANVKSSAHLRV--KPRVIGLLRPLKDVTVTAG 12210
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
E T CE S + IP + W + + +K +V RS +V +LTL+ ++ DAGE
Sbjct: 12211 ETATFDCELSYEDIP-VEWYLKGKKLEPSDK-----VVPRSEGKVHTLTLRDVKLEDAGE 12264
Query: 383 YICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWF 439
TA + + +++++ V++ L+ EG + CEV + +A + WF
Sbjct: 12265 VQLTAKDF--KTHANLFVKEPPVEFTKPLEDQTVE---EGATAVLECEV-SRENAKVKWF 12318
Query: 440 RDG-QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
++G ++L S Y + + TP+ D Y C A
Sbjct: 12319 KNGTEILKSKKYEIVADGRVRKLVIHDCTPE---DIKTYTCDA 12358
Score = 57.8 bits (138), Expect = 4e-08
Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 14/254 (5%)
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
P I+W + L +IK +T ++L ++ D G Y T N G++
Sbjct: 19721 PPPKITWSKPNVNLRDRIGLDIK--STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYT 19778
Query: 492 FILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWY 550
++ DTP P ++ E +A V ++ P GG PI+ Y + R + W +
Sbjct: 19779 IVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTT 19838
Query: 551 DAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610
+ + S + L+ +Y R+ A N G+G+ E + + P ++ +
Sbjct: 19839 ECSKTSFR----VANLEEGKSYFFRVFAENEYGIGD---PGETRDAVKASQTPGPVVDLK 19891
Query: 611 M-GEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNA 668
+ +S + K DGGS I Y+V + ++W+ ++ S S K L
Sbjct: 19892 VRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMK--SLSLQYSAKDLTEGK 19949
Query: 669 EYEVYVVAENQQGK 682
EY V AEN+ G+
Sbjct: 19950 EYTFRVSAENENGE 19963
Score = 57.8 bits (138), Expect = 4e-08
Identities = 99/403 (24%), Positives = 159/403 (39%), Gaps = 62/403 (15%)
Query: 213 TIQARQNIV-NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ 271
TI+A IV NA + LG+ P P SW+K G+ I + D + + SS
Sbjct: 20389 TIKAGDTIVLNAISILGK-----------PLPKSSWSKAGKDI-RPSDITQITSTPTSSM 20436
Query: 272 LTIKKVDKNDEAEYICIAENKAG---EQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
LTIK + D EY A N G E L V P + N +A + T
Sbjct: 20437 LTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP 20496
Query: 329 CEASGDPIPS--ITWRTSTR---NISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
E G PI S + R ++R + SE+ ++S V++ ++ +Y +
Sbjct: 20497 LEDGGSPIKSYILEKRETSRLLWTVVSED--------IQSCRHVATKLIQGNEYI----F 20544
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFR--- 440
+A N G+ V+ + P E + V +AT+SW R
Sbjct: 20545 RVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKN-------TATVSWKRPVD 20597
Query: 441 DG---------QLLPSSNYSNIKIYNTP-SASYLEVTPDSENDFGNYNCTAVNRIG---- 486
DG + + ++ TP S +VT E + +A NR G
Sbjct: 20598 DGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPP 20657
Query: 487 QESLEFILVQ--ADTPSSPSIDQV-EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543
E+ + +L++ A P PS V + +A + + +P GG+ I Y E + VG+E
Sbjct: 20658 SEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
W + +V L+ + Y R++A+N G+GE
Sbjct: 20718 AWIKDTTGTALRITQFVVP--DLQTKEKYNFRISAINDAGVGE 20758
Score = 57.8 bits (138), Expect = 4e-08
Identities = 68/270 (25%), Positives = 99/270 (36%), Gaps = 12/270 (4%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + I ++ P ISW +DG + + +I +T + + L V D G Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIISTDNHTLLTVKDCIRRDTGQYV 25861
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
T N G S+ D P P+ +E TA+ + + P+ GG I Y
Sbjct: 25862 LTLKNVAGTRSVAVNCKVLDKPGPPA-GPLEINGLTAEKCSLSWGRPQEDGGADIDYYIV 25920
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKT 595
E R E H W + + L Y R+ +N G+GE + K
Sbjct: 25921 EKR----ETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKA 25976
Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSS-EWKPEIRLP 653
PS P S+ + + + DGGS I Y++ R +S W + P
Sbjct: 25977 LDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKP 26036
Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
V L EYE V AEN G S
Sbjct: 26037 VYDLRVKSTGLREGCEYEYRVYAENAAGLS 26066
Score = 57.4 bits (137), Expect = 6e-08
Identities = 68/300 (22%), Positives = 117/300 (39%), Gaps = 25/300 (8%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE------- 471
G+Q+ I + P+ SW DG+ + +++ P + LE +S
Sbjct: 15825 GSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDG---VHDIPEDAQLETAENSSVIIIPEC 15881
Query: 472 --NDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGV 528
+ G Y+ TA N+ GQ++ + D P P +V + + ++ + P+ GG
Sbjct: 15882 KRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGD 15941
Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
I Y E R + + W D + + L E Y R+ A N G+G
Sbjct: 15942 RIKGYVIEKRTIDGKAWTKVNPDCGSTTF----VVPDLLSEQQYFFRVRAENRFGIGPPV 15997
Query: 589 AASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVNLIK-QDDGGSPIRHYLVRYRA----- 641
+ T P P ++ ++G N++ ++ ++DGGSP+ HY+V A
Sbjct: 15998 ETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTG 16057
Query: 642 -LSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 700
W+ + ++ L EYE V A N G SK + V Q +P
Sbjct: 16058 TKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMP 16117
Score = 57.0 bits (136), Expect = 7e-08
Identities = 66/303 (21%), Positives = 115/303 (37%), Gaps = 13/303 (4%)
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
N + I YP T +W ++L + + +K+ + + L ++P +D G Y
Sbjct: 13410 NPITILVPSTGYPRPTATWCFGDKVLETGD--RVKMKTLSAYAELVISPSERSDKGIYTL 13467
Query: 480 TAVNRIGQESLEFILVQADTPSSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
NR+ S E + PS+P + + + + ++ P+ GG P+ Y E R
Sbjct: 13468 KLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKR 13527
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPV 598
V + W + T+ L Y ++ A N G GE + E
Sbjct: 13528 EVSRKTWTKVMDFVTDLEF----TVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMST 13583
Query: 599 QGE-PSAPKLEGQMGEDGNSIKVNL-IKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGS 656
P P+ NSI + ++DGGS I+ Y+V S+ P
Sbjct: 13584 PATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAE 13643
Query: 657 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVG 716
+ + L+ Y V A N+QG SK + R + + A+ +P L + G
Sbjct: 13644 TKMEVTGLEEGKWYAYRVKALNRQGASKPS----RPTEEIQAVDTQEAPEIFLDVKLLAG 13699
Query: 717 ILI 719
+ +
Sbjct: 13700 LTV 13702
Score = 56.6 bits (135), Expect = 9e-08
Identities = 88/424 (20%), Positives = 155/424 (36%), Gaps = 57/424 (13%)
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G I AR EI+ + + I +V+A G++ L D G P P + W+KD
Sbjct: 24694 GAITARDEIDAPNASLDPKYKDVI-----VVHA----GETFVLEADIRGKPIPDVVWSKD 24744
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKI 310
G+++E+ + + + L +K + D +YI N G + I +KV +P
Sbjct: 24745 GKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPG- 24803
Query: 311 TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSL 370
+ +++ C + +P P + + E++ + V +L
Sbjct: 24804 ---PPEGPLKVTGVTAEKCYLAWNP-PLQDGGANISHYIIEKRETSRLSWTQVSTEVQAL 24859
Query: 371 TLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAV---YTWEGNQVNIT 425
K + EYI A N G P GPV Y G
Sbjct: 24860 NYKVTKLLPGNEYIFRVMAVNKYGIGE----------PLESGPVTACNPYKPPGPPSTPE 24909
Query: 426 CEVFAYPSATISWFR---------DGQLLPSSNYSNIK----IYNTPSASYLEVTPDSEN 472
S ++W R +G +L + ++ T + L VT +E
Sbjct: 24910 VSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEG 24969
Query: 473 DFGNYNCTAVNR--IGQESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPE 523
+ A N +G+ S + +A PS+P + + S+ + + +P
Sbjct: 24970 HSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKV--TDTSRSSVSLAWSKPI 25027
Query: 524 ATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG-IVTIVGLKPETTYAVRLAALNGK 582
GG P+ Y E + + W + ++G T+ LK T Y R+ A+N +
Sbjct: 25028 YDGGAPVKGYVVEVKEAAADEWTT---CTPPTGLQGKQFTVTKLKENTEYNFRICAINSE 25084
Query: 583 GLGE 586
G+GE
Sbjct: 25085 GVGE 25088
Score = 56.6 bits (135), Expect = 9e-08
Identities = 94/398 (23%), Positives = 150/398 (37%), Gaps = 29/398 (7%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G SV L G P PT+ W KD +++ Q + D + + IK D+ + Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKEL-QTNALVCVENTTDLASILIKDADRLNSGCYEL 26945
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
N G ATI +++ KP + E++TL D + + +
Sbjct: 26946 KLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGA---KITHYI 27002
Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI----CTASNTIGQDSQSMYLEVQ 403
+ E + +V H +T I EYI IG+ +S + +
Sbjct: 27003 VEKRETSRVVWSMVSEHLEECIITTTKI--IKGNEYIFRVRAVNKYGIGEPLESDSVVAK 27060
Query: 404 YAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNI----KIYNTP 459
A GP + N V++ P A G L + ++ + T
Sbjct: 27061 NAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETI 27120
Query: 460 SASYLEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILV--QADTPSSPS-IDQVEPYS 512
+ +VT +EN Y AVN GQ E EF D P P+ I +
Sbjct: 27121 RDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTK 27180
Query: 513 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 572
S+ + + +P GG + Y E R EE W + + + E +V+ LKP Y
Sbjct: 27181 SSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVS--NLKPGVNY 27238
Query: 573 AVRLAALNGKGLGEISAASEFKTQPVQGEP--SAPKLE 608
R++A+N G GE +E PVQ + AP+++
Sbjct: 27239 YFRVSAVNCAGQGEPIEMNE----PVQAKDILEAPEID 27272
Score = 56.6 bits (135), Expect = 9e-08
Identities = 72/324 (22%), Positives = 121/324 (37%), Gaps = 44/324 (13%)
Query: 22 VDIVPSQGEI--SVGESKF---FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDD 76
++I P G+I +VGE ++C++ + ++W+ G + N ++ + + +D
Sbjct: 31565 IEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYF--GVRQLENSEKYEITY-ED 31621
Query: 77 SSSTLTIYNANIDDAGIYKCVVT---GEDGSESEATVN---------VKIFQKLMFKNAP 124
+ L + + D G Y+C V GED S +E V + K + +
Sbjct: 31622 GVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTD 31681
Query: 125 T------PQEFR---------EGEDAVIVCDVVSSLPPTIIWKHKGRDVIL-KKDVRFIV 168
T P EF GE+ + P + W G+ + D ++
Sbjct: 31682 TMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTF 31741
Query: 169 LSNN---YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQA-----RQNI 220
S+ L I + D+ Y R + + V ++ PPT ++ +
Sbjct: 31742 ESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLL 31801
Query: 221 VNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
NA GQSV G P PT+ W KDG+ + + E D L I+
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861
Query: 281 DEAEYICIAENKAGEQDATIHLKV 304
D Y A N AG HL+V
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 56.6 bits (135), Expect = 9e-08
Identities = 77/402 (19%), Positives = 135/402 (33%), Gaps = 110/402 (27%)
Query: 105 ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
E T +K P EGE A CD PT+ W KG+ +L
Sbjct: 32548 EKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQ--VLSTSA 32605
Query: 165 RFIVLSNNY---LQIRGIKKTDEGTY-----RCEGRILARGEINFKDIQV---IVNVPPT 213
R V + Y +I ++ +DEG Y EG+ A + + +V V PP
Sbjct: 32606 RHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR 32665
Query: 214 IQARQNIVNATANLGQSVTL----------VCDAEGFPEPT------------------- 244
+++ + V + + + V E P PT
Sbjct: 32666 VKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLK 32725
Query: 245 -----------------------MSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281
++W KDG+++++ + + +D + +L I + ++D
Sbjct: 32726 AEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESD 32785
Query: 282 EAEYIC-----------------------------IAENKAGEQ---DATIHLK------ 303
+ EY+C I+E K +Q ++T+ K
Sbjct: 32786 QGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAP 32845
Query: 304 --VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVV 361
+ +KP I T + + +A+G+P P+ W + I T G +
Sbjct: 32846 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI-----TQGGKYKL 32900
Query: 362 RSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ 403
L + +D+G Y CT N+ G S S L ++
Sbjct: 32901 SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 2/101 (1%)
Query: 209 NVPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
NVPP I + + T G +V L G P PT+SW KDG ++ E K
Sbjct: 19290 NVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGI-KMAMQR 19348
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+ L + V++ D +Y AEN +G + ATI LKV KP
Sbjct: 19349 NLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKP 19389
Score = 56.2 bits (134), Expect = 1e-07
Identities = 63/291 (21%), Positives = 101/291 (34%), Gaps = 16/291 (5%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G + + P+ ++W +D +P + + +T + S L + D G+Y
Sbjct: 22162 GEDLKVDVPFIGRPTPAVTWHKDN--VPLKQTTRVNAESTENNSLLTIKDACREDVGHYV 22219
Query: 479 CTAVNRIGQ--ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
N G+ E+L I++ P + + E + + + + P+ GG I Y E
Sbjct: 22220 VKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVE 22279
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQ 596
R W +++ LK Y R+AA N G + Q
Sbjct: 22280 KRDTSTTTWQIVSATVARTTIKAC----RLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQ 22335
Query: 597 ---PVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP 653
V G P P + D ++ N D G I ++L R S W + P
Sbjct: 22336 YPFKVPGPPGTPVVT-LSSRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTP 22394
Query: 654 SGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH----FVFRTSAQPTAIP 700
L+ EYE V AEN G K + +V R P P
Sbjct: 22395 IPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRP 22445
Score = 56.2 bits (134), Expect = 1e-07
Identities = 66/275 (24%), Positives = 106/275 (38%), Gaps = 24/275 (8%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + + P+ TI W++D + L ++ + + + NT + + + + G Y
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYE 26944
Query: 479 CTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKA 535
N +G S + D P P +E + TA+ + + P GG I Y
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPG-GPIEFKTVTAEKITLLWRPPADDGGAKITHYIV 27003
Query: 536 EWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE------ISA 589
E R VW E E I+T + Y R+ A+N G+GE + A
Sbjct: 27004 EKRETSRVVWSM----VSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059
Query: 590 ASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSS-EWK 647
+ F T G P K+ NS+ V + DGGS I Y + R S W
Sbjct: 27060 KNAFVTPGPPGIPEVTKI------TKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWF 27113
Query: 648 PEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 682
++ + L N++Y+ V A N G+
Sbjct: 27114 KVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQ 27148
Score = 55.8 bits (133), Expect = 2e-07
Identities = 123/602 (20%), Positives = 219/602 (36%), Gaps = 93/602 (15%)
Query: 130 REGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL---SNNYLQIRGIKKTDEGT 186
+ GED ++ PPT+ W+ ++ L D R+ + S++ L I + + D G
Sbjct: 27284 KAGEDVQVLIPFKGRPPPTVTWRKDEKN--LGSDARYSIENTDSSSLLTIPQVTRNDTGK 27341
Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPT 244
Y + G K V V V T A Q + + G +VTL+ D P
Sbjct: 27342 YILT---IENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRG-TVTLLWDPPLIDGGSPI 27397
Query: 245 MSWTKDGEQIEQEEDDEKY--IFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQDATI 300
+++ IE+ + ++ + S S + K +D +++ + +AEN+ G
Sbjct: 27398 INYV-----IEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIG------ 27446
Query: 301 HLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN---ISSEEKTLDG 357
+P T E A E+ PI ++ + ST+ +S + DG
Sbjct: 27447 ----IGEPCET-TEPVKAAEVPA-----------PIRDLSMKDSTKTSVILSWTKPDFDG 27490
Query: 358 HMVVR--------------SHARVSS---LTLKSIQYTDAGEYICTASN--------TIG 392
V+ SHA +S + + ++ E+ A N TIG
Sbjct: 27491 GSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIG 27550
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
+ + P A T G+ V++ P +ISW +DG L S +
Sbjct: 27551 PITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEF- 27609
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS----IDQ 507
++ T + L + + G Y N + + ++ ++ PS P D+
Sbjct: 27610 -VRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDE 27668
Query: 508 VEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLK 567
++ + + + +D PE GG I Y E R + W + + + L
Sbjct: 27669 IK--ADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFK----VPNLV 27722
Query: 568 PETTYAVRLAALNGKGLGE------ISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVN 621
+ Y R+ A N G+ + I A +F+ + G P P + + DG S+ +
Sbjct: 27723 KDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFR---IPGPPGKPVIY-NVTSDGMSLTWD 27778
Query: 622 LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681
D G ++ + S W+ P L +Y+ V AEN G
Sbjct: 27779 APVYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAG 27838
Query: 682 KS 683
S
Sbjct: 27839 LS 27840
Score = 55.5 bits (132), Expect = 2e-07
Identities = 115/520 (22%), Positives = 194/520 (37%), Gaps = 56/520 (10%)
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
G I KD + + + R IV N G++ L D G P PT+ W + ++IE+
Sbjct: 23612 GPITAKDEVELPRISMDPKFRDTIV---VNAGETFRLEADVHGKPLPTIEWLRGDKEIEE 23668
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E +D + L +K + D +YI A N AG + +++KV +P Q
Sbjct: 23669 SARCE-IKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQ 23727
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
E+ +LT P+ S + E + VV S +S LK +
Sbjct: 23728 VTGVTSEKCSLTW---SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNS--LKVTK 23782
Query: 377 YTDAGEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
+ EY+ A N G ++ AP L V + +T A S
Sbjct: 23783 LLEGNEYVFRIMAVNKYGVGE-----PLESAPVLMKNPFVLPGPPKSLEVT--NIAKDSM 23835
Query: 435 TISWFRD---------GQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTA 481
T+ W R G ++ + S I+ L VT +E+ + +A
Sbjct: 23836 TVCWNRPDSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSA 23895
Query: 482 VNR--IGQESLEFILVQADTP-----SSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
N +G+ S + +A P + V+ ++ + + +P GG IL Y
Sbjct: 23896 ENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYV 23955
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E EE W + + I L Y +R+ ALN GLGE A S
Sbjct: 23956 VEICKADEEEW--QIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGE--ATSVPG 24011
Query: 595 TQPVQGEPSAPKLE-------GQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWK 647
T + + AP+L+ G + G S ++++ + G P + + E+
Sbjct: 24012 TVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFK---GRPTPE--ITWSREEGEFT 24066
Query: 648 PEIRLPSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKA 685
++++ G ++ L + D N + + EN G A
Sbjct: 24067 DKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSA 24106
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 14/133 (10%)
Query: 190 EGRILARGEINFKDIQVIVNV-------PPTIQARQNIVNATANL--GQSVTLVCDAEGF 240
E R+ A EI + + +NV PPTI+ R ++ T + G+ V + D G
Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 15425
Query: 241 PEPTMSWTKDGEQIEQEED-----DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
P P + W+K+ IE+ D E+ S+ ++L+I K + D+ Y A N+ G
Sbjct: 15426 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Query: 296 QDATIHLKVFAKP 308
+H++V+ +P
Sbjct: 15486 VFRNVHVEVYDRP 15498
Score = 55.1 bits (131), Expect = 3e-07
Identities = 80/363 (22%), Positives = 138/363 (38%), Gaps = 27/363 (7%)
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIG--QDSQSMYLEVQYAPKLQGPVAVYTW 417
V H + + T++ + E+ A N G + ++ + P+++ P A T
Sbjct: 28593 VEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIE-PTADLTG 28651
Query: 418 EGNQVNITCE----------VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVT 467
NQ+ ITC+ + P+ ++W + L ++ + I T + L V
Sbjct: 28652 ITNQL-ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETD--RVSITTTKDRTTLTVK 28708
Query: 468 PDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEA 524
D G Y T N G ++ +V P P +E S +A+ + + EP+
Sbjct: 28709 DSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG-PVTGPIEVSSVSAESCVLSWGEPKD 28767
Query: 525 TGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGL 584
GG I Y E R G W K + + L Y+ R+++ N G+
Sbjct: 28768 GGGTEITNYIVEKRESGTTAWQLVNSSVKRTQ----IKVTHLTKYMEYSFRVSSENRFGV 28823
Query: 585 GEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALS 643
+ ++ + PSAP N++ + + DGGS I Y V + +
Sbjct: 28824 SKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERN 28883
Query: 644 S-EWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702
+ W E ++P + + L EY+ A N G SKA+ AQ + A
Sbjct: 28884 TILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQ-NPVDAP 28942
Query: 703 GSP 705
G P
Sbjct: 28943 GRP 28945
Score = 54.7 bits (130), Expect = 4e-07
Identities = 72/339 (21%), Positives = 127/339 (37%), Gaps = 20/339 (5%)
Query: 246 SWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF 305
+W KDG I +E ++I +L I V +D EY C+ E+ +T L V
Sbjct: 11150 TWMKDGSNI-RESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVE 11208
Query: 306 AKPK--ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
P + +E + + + + L+CE + + + WR + + + G +V
Sbjct: 11209 ELPVRFVKTLEEEVTVVKGQPLYLSCELNKE--RDVVWRKDGKIVVEK----PGRIVPGV 11262
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-LQGPVAVYTWEGNQV 422
+ +LT+ TDAG Y T N + S V+ L P+ +
Sbjct: 11263 IGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGT 11322
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
I A + I WF+ +P+ +I + YL++ D Y AV
Sbjct: 11323 AIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY---AV 11379
Query: 483 NRIGQE-SLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVG 541
G+ + L + + I+ V Y + FD + +P +W+ G
Sbjct: 11380 EIEGKRYPAKLTLGEREVELLKPIEDVTIYEKES-ASFDAEISEADIP-----GQWKLKG 11433
Query: 542 EEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
E + S + K + +T+ +K + V ALN
Sbjct: 11434 ELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQALN 11472
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/306 (20%), Positives = 122/306 (39%), Gaps = 36/306 (11%)
Query: 16 TAVSLQVDIVPSQGEISVGESKF--FLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVW 73
T +++D +++V E + F C + +A ++ W G + + + ++
Sbjct: 11480 TVKEIELDFAVPLKDVTVPERRQARFECVLTREA---NVIW--SKGPDIIKSSDKFDII- 11533
Query: 74 NDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGE 133
D L I ++ DD G+Y V G+ S ++ L F + Q +EGE
Sbjct: 11534 ADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLFVTGIR----LKFMSPLEDQTVKEGE 11589
Query: 134 DAVIVCDVVSSLPPTIIWK-----HKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYR 188
A VC++ + +K H R V++ + + + L+++ + D +
Sbjct: 11590 TATFVCELSHEKMHVVWFKNDAKLHTSRTVLISSEGK-----THKLEMKEVTLDDISQIK 11644
Query: 189 CEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWT 248
+ + E++ ++ P + + + TA +TL C+ + + W
Sbjct: 11645 AQVK-----ELSSTAQLKVLEADPYFTVKLH--DKTAVEKDEITLKCEVS--KDVPVKWF 11695
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQ--LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
KDGE+I KY D + L IKK D D+ EY+C + + T+ ++
Sbjct: 11696 KDGEEIVPSP---KYSIKADGLRRILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIK 11752
Query: 307 KPKITY 312
K Y
Sbjct: 11753 VEKPLY 11758
Score = 54.7 bits (130), Expect = 4e-07
Identities = 70/287 (24%), Positives = 108/287 (37%), Gaps = 14/287 (4%)
Query: 405 APKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS 460
APK++ V V G + +V P T+ W +DG+ L + IKI
Sbjct: 21458 APKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKI--ADF 21515
Query: 461 ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPS--IDQVEPYSSTAQVQ 518
++ L + D G Y TA N G F + D P P + E S +
Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLS 21575
Query: 519 FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAA 578
+ P GG I Y + R W + + + ++ + L Y R+ A
Sbjct: 21576 WFPPLDDGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLK----VTKLLKGNEYIFRVMA 21631
Query: 579 LNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQD-DGGSPIRHYLV 637
+N G+GE + G P PK +S+ V D DGGS I +Y+V
Sbjct: 21632 VNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIV 21691
Query: 638 RYRALSSEWKPEIRLPSGSD-HVMLKSLDWNAEYEVYVVAENQQGKS 683
R + + + + +D + L EYE ++AEN G S
Sbjct: 21692 ERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGIS 21738
Score = 54.7 bits (130), Expect = 4e-07
Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%)
Query: 419 GNQVNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSEN--DFG 475
G + + + P+ + W + DG++ ++ ++S+ + D+ N D G
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIID-------VTSSFTSLVLDNVNRYDSG 23009
Query: 476 NYNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
Y T N G +S + DTPS P ++ E + + ++ P GG I Y
Sbjct: 23010 KYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYI 23069
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLG-EISAASEF 593
E R + + + + + S + I L+ +Y R+ A N G+G A
Sbjct: 23070 VEKREATRKSYAAVVTNCHKNSWK----IDQLQEGCSYYFRVTAENEYGIGLPAQTADPI 23125
Query: 594 KTQPVQGEPSAPKLEGQMGEDG---NSIKVNLIKQD-DGGSPIRHYLVRYRALSSE-WKP 648
K V P+ G++ D NS+ ++ K + DGGS I Y+V +A SE W
Sbjct: 23126 KVAEV------PQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE 23179
Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
R+ S ++ +L EY VVA N++G+S
Sbjct: 23180 CARVK--SLQAVITNLTQGEEYLFRVVAVNEKGRS 23212
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/230 (25%), Positives = 95/230 (41%), Gaps = 16/230 (6%)
Query: 462 SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTA-QVQFD 520
++L + + +D G Y+ T VN G++++ + DTP S +V + T+ V +
Sbjct: 18661 AFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWA 18720
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
PE GG + Y E R + W + + K+ S + L P Y R+ A+N
Sbjct: 18721 PPENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFH----VTNLVPGNEYYFRVTAVN 18776
Query: 581 --GKGLGEISAASEFKTQPVQGEPSAP-KLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV 637
G G+ + P+ EP P KLE ++ L DGG+ I Y+
Sbjct: 18777 EYGPGVPTDVPKPVLASDPL-SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYIT 18835
Query: 638 RYRALSSEWKPEIRLPSGSD----HVMLKSLDWNAEYEVYVVAENQQGKS 683
YR E +P R S +++ L +Y+ V A N G S
Sbjct: 18836 SYR---EEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 18882
Score = 54.3 bits (129), Expect = 5e-07
Identities = 125/579 (21%), Positives = 212/579 (36%), Gaps = 75/579 (12%)
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQV 206
P ++W D+ + V S L I + D G Y + + ++ + +
Sbjct: 26216 PNVLWSKPDTDLRTRAYVD-TTDSRTSLTIENANRNDSGKYT----LTIQNVLSAASLTL 26270
Query: 207 IVNV-----PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDE 261
+V V PPT Q++ +A L V PE IE+ E +
Sbjct: 26271 VVKVLDTPGPPTNITVQDVTKESAVLSWDV---------PENDGGAPVKNYHIEKREASK 26321
Query: 262 KYIFS--DDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
K S ++ ++L+ K + + A Y +GE + + + K + E +
Sbjct: 26322 KAWVSVTNNCNRLSYKVTNLQEGAIYYF---RVSGENEFGVGIPAETKEGVKITEKPSP- 26377
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-----VSSLTLKS 374
E++ +T S D + S+TW + S H VV + + V KS
Sbjct: 26378 --PEKLGVT-SISKDSV-SLTWLKPEHDGGSRIV----HYVVEALEKGQKNWVKCAVAKS 26429
Query: 375 IQYTDAG-----EYICT--ASNTIG-QDSQSMYLEVQYAPKLQGPV---------AVYTW 417
+ +G EY A N G D + + L V +L+ P VY
Sbjct: 26430 THHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVR 26489
Query: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G+ + + + P ++ RDG L ++ N +I T + + D G Y
Sbjct: 26490 AGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEI--TAENLTINLKESVTADAGRY 26547
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPS----IDQVEPYSSTAQVQFDEPEATGGVPILKY 533
TA N G +V D P P+ I + S T ++++ P+ GG + Y
Sbjct: 26548 EITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVT--LKWEPPKYDGGSQVTNY 26605
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASE 592
R VW + ++ ++ L Y R+ A N G+ + I +A
Sbjct: 26606 ILLKRETSTAVWT----EVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACV 26661
Query: 593 FKTQP--VQGEPSAPKLEGQMGEDGNSIKVNLIKQ-DDGGSPIRHYLVRYRALSSE-WKP 648
P G PS P + E SI V + +GGS + Y + + +S W+
Sbjct: 26662 TVKLPYTTPGPPSTPWVTNVTRE---SITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQK 26718
Query: 649 EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAH 687
+L + H + ++ YE V AEN G K +H
Sbjct: 26719 ANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSH 26757
Score = 53.9 bits (128), Expect = 6e-07
Identities = 87/379 (22%), Positives = 147/379 (38%), Gaps = 35/379 (9%)
Query: 325 VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
V L SG P P+I W + + + + + V + ++S+ +K ++G Y
Sbjct: 26890 VKLRAGISGKPAPTIEWYKDDKELQT-----NALVCVENTTDLASILIKDADRLNSGCYE 26944
Query: 385 CTASNTIGQDSQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQ 443
N +G S ++ +++ P G P+ T ++ + P A +
Sbjct: 26945 LKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWR----PPADDGGAKITH 27000
Query: 444 LLPSSNYSNIKIYNTPSASYLE-VTPDSENDFGN---YNCTAVNRIG-QESLEFILVQAD 498
+ ++ +++ S E + ++ GN + AVN+ G E LE V A
Sbjct: 27001 YIVEKRETSRVVWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAK 27060
Query: 499 ----TPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
TP P I +V + + V + P A GG I Y E R W K
Sbjct: 27061 NAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKV---LK 27117
Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE 613
E + + GL + Y R+ A+N G G S SEF +P P + ++ +
Sbjct: 27118 ETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIAD 27177
Query: 614 D-GNSIKVNLIKQ-DDGGSPIRHYLVRYR-ALSSEW-----KPEIRLPSGSDHVMLKSLD 665
+SI + K DGGS + Y+V R EW K E+R + ++ +L
Sbjct: 27178 STKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR----TTEYVVSNLK 27233
Query: 666 WNAEYEVYVVAENQQGKSK 684
Y V A N G+ +
Sbjct: 27234 PGVNYYFRVSAVNCAGQGE 27252
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 9/113 (7%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ KDI + + R +++ A G+ V ++ +G P PT++W KD + +
Sbjct: 27260 VQAKDILEAPEIDLDVALRTSVI---AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGS-- 27314
Query: 259 DDEKYIF--SDDSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKP 308
D +Y +D SS LTI +V +ND +YI EN GE + +T+ +KV P
Sbjct: 27315 -DARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTP 27366
Score = 53.9 bits (128), Expect = 6e-07
Identities = 85/368 (23%), Positives = 135/368 (36%), Gaps = 64/368 (17%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELE------- 322
++ T+ + +E ++ A N AG+ D+ I V+ TA EL+
Sbjct: 28311 TRYTVTDLQAGEEYKFRVSAINGAGKGDSCE-----VTGTIKAVDRLTAPELDIDANFKQ 28365
Query: 323 -------EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+ L G P P+ W N+S + + S+LT+++
Sbjct: 28366 THVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRAD-------IHTTDSFSTLTVENC 28418
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
DAG+Y T N G S + ++V P GP IT + SAT
Sbjct: 28419 NRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGP------------ITFKDVTRGSAT 28466
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSE---------NDFGN-----YNCTA 481
+ W D LL + + AS SE ND + +A
Sbjct: 28467 LMW--DAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSA 28524
Query: 482 VNRIG---QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
VN G + +V + P+ P +D V+ S+A + + +P+ GG I Y E
Sbjct: 28525 VNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEM 28584
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE-ISAASEFKTQ 596
R G + W + + + T+ L +T Y R+ A N G E A S +
Sbjct: 28585 RQKGSDFWVEAGH-----TKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIK 28639
Query: 597 PVQGEPSA 604
Q EP+A
Sbjct: 28640 EPQIEPTA 28647
Score = 53.5 bits (127), Expect = 8e-07
Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 1/81 (1%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G+ + + D G P P +SW KDG +IE+ E I +D+ + LT+K + D +Y+
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTE-IISTDNHTLLTVKDCIRRDTGQYVL 25862
Query: 288 IAENKAGEQDATIHLKVFAKP 308
+N AG + ++ KV KP
Sbjct: 25863 TLKNVAGTRSVAVNCKVLDKP 25883
Score = 52.8 bits (125), Expect = 1e-06
Identities = 101/457 (22%), Positives = 175/457 (38%), Gaps = 65/457 (14%)
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-----KPKITYVE--NQTAMEL 321
S + T+K + + D EY A N G+ + K P +++ ++ + +
Sbjct: 16773 SRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRV 16832
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK----SIQY 377
E LT SG P P ++W ++ +++T H + + TL +
Sbjct: 16833 GEAFALTGRYSGKPKPKVSWFKDEADVLEDDRT---------HIKTTPATLALEKIKAKR 16883
Query: 378 TDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATIS 437
+D+G+Y N+ G S+ + +V + PV +++ +T + IS
Sbjct: 16884 SDSGKYCVVVENSTG--SRKGFCQVNVVDRPGPPVGPVSFD----EVTKDYMV-----IS 16932
Query: 438 W---FRDGQLLPSSNYSNIK----------IYNTPSASYLEVTPDSENDFGNYNCTAVNR 484
W DG +NY K + + + + +V+ E + A N
Sbjct: 16933 WKPPLDDGGS-KITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLLEGKDYIFRIHAENL 16991
Query: 485 IG-QESLEFILVQA-------DTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAE 536
G + L ++A D P P + +V +A V +++P GG PI Y E
Sbjct: 16992 YGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVT--KDSALVTWNKPH-DGGKPITNYILE 17048
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE--FK 594
R + W D + + L Y R++A N G+G+ S S+ F
Sbjct: 17049 KRETMSKRWARVTKDPIHPYTK--FRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFA 17106
Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRAL-SSEWKPEIRL 652
P+ +PS P + NS+ + + DGGS I Y+V Y+ + EW+
Sbjct: 17107 KDPI-AKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHT 17165
Query: 653 PSGSDHVMLK--SLDWNAEYEVYVVAENQQGKSKAAH 687
P K L Y+ V+A N G+S AH
Sbjct: 17166 PESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202
Score = 52.0 bits (123), Expect = 2e-06
Identities = 111/483 (22%), Positives = 179/483 (37%), Gaps = 61/483 (12%)
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNV 210
W R L+ + + YL R + ++G R + R LA I KD+ + +V
Sbjct: 23177 WSECARVKSLQAVITNLTQGEEYL-FRVVAVNEKG--RSDPRSLAV-PIVAKDLVIEPDV 23232
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
P + + +GQ + + G P+PT++WTKDG ++Q S D +
Sbjct: 23233 KPAFSSY------SVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQ-TTRINVTDSLDLT 23285
Query: 271 QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCE 330
L+IK+ K+D +Y N G++ A+I + KP + E +TL
Sbjct: 23286 TLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL--- 23342
Query: 331 ASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTAS 388
S +P P T N +++ + A V+ TLK + EY A
Sbjct: 23343 -SWNP-PLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAE 23400
Query: 389 NTIGQD--SQSMYLEVQYAPKLQGPVA------------VYTWEGNQVNITCEVFAY--- 431
N GQ +S + QY K GP V W N V Y
Sbjct: 23401 NRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLE 23460
Query: 432 --PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
+I W + + + + + K N E +EN G V + + S
Sbjct: 23461 RKERNSILWTKVNKTI--IHDTQFKAQNLEEGIEYEFRVYAENIVG------VGKASKNS 23512
Query: 490 LEFILVQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSK 548
++ D P +P V+ T +Q+ +P GG I Y E R + + +
Sbjct: 23513 ECYVARDPCDPPGTPEPIMVKRNEIT--LQWTKPVYDGGSMITGYIVEKRDLPD----GR 23566
Query: 549 WYDAKEAS-MEGIVTIVGLKPETTYAVRLAALNGKG--------LGEISAASEFKTQPVQ 599
W A + +E T+ GL + Y R+ A N G G I+A E + +
Sbjct: 23567 WMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRIS 23626
Query: 600 GEP 602
+P
Sbjct: 23627 MDP 23629
Score = 51.2 bits (121), Expect = 4e-06
Identities = 47/182 (25%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK---DVRFIVLSNNY-LQIRGIKKTDEGT 186
+G ++ V P T W +D ++++ V ++ N Y +I+ EG
Sbjct: 17830 DGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEG- 17888
Query: 187 YRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMS 246
E R LA I KDI V + R I T +GQ++ ++ +G PEP ++
Sbjct: 17889 ---EPRELAESVIA-KDILHPPEVELDVTCRDVI---TVRVGQTIRILARVKGRPEPDIT 17941
Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
WTK+G+ + +E+ + I +L IK+ + D +YI A+N +G + + V
Sbjct: 17942 WTKEGKVLVREKRVD-LIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLD 18000
Query: 307 KP 308
+P
Sbjct: 18001 RP 18002
Score = 50.8 bits (120), Expect = 5e-06
Identities = 47/205 (22%), Positives = 89/205 (43%), Gaps = 13/205 (6%)
Query: 405 APKLQGPV-AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASY 463
AP P+ +V EG+ + +P +SWFRDGQ++ +S ++I + +
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTPSSPSIDQVEPYS--STAQVQFD 520
L + ++ + G Y+ A N GQ S +LV+A+T + +++ + +QV+
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 521 EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALN 580
P++K+ + G E+ S + + + I PE + + A N
Sbjct: 125 VRVTGIPTPVVKFYRD----GAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 581 GKGLGEISAASEFKTQPVQGEPSAP 605
+G ++ +E VQGE P
Sbjct: 181 --SVGRATSTAELL---VQGEEEVP 200
Score = 50.4 bits (119), Expect = 7e-06
Identities = 108/509 (21%), Positives = 181/509 (35%), Gaps = 50/509 (9%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
I KD V ++ R IV + G + ++ G P PT++W + + QE
Sbjct: 16513 IEMKDRLVSPDLQLDASVRDRIV---VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEA 16569
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
E S S + IK ++ + Y +A+N+AGE+ TI + V P
Sbjct: 16570 TIETTAIS---SSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAH 16626
Query: 319 MELEEQVTLTCEASGDP--IPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
E LT + D P + R T + V R +A V L
Sbjct: 16627 NLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAY 16686
Query: 377 YTDAGEYICTASNTIG-----QDSQSMYL-EVQYAPKLQGPVAVYTWEGNQVNITCEVFA 430
+ + A N+IG + S+++ + E P+ + V N V +T
Sbjct: 16687 F-----FRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPK 16741
Query: 431 YP--SATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
Y S I++ + +L+ + + + N S Y V E D Y +AVN +GQ
Sbjct: 16742 YDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKY-TVKGLKEGDTYEYRVSAVNIVGQG 16800
Query: 489 SLEFI---LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVW 545
F + D + P++ + ++ E A G R G+
Sbjct: 16801 KPSFCTKPITCKDELAPPTLHL--DFRDKLTIRVGEAFALTG----------RYSGKPKP 16848
Query: 546 HSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL---NGK-------GLGEISAASEFKT 595
W+ + +E T + P T ++ A +GK G +
Sbjct: 16849 KVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNV 16908
Query: 596 QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE-WKPEIRLPS 654
G P P ++ +D I DDGGS I +Y++ + + + W P + S
Sbjct: 16909 VDRPGPPVGPVSFDEVTKDYMVISWK-PPLDDGGSKITNYIIEKKEVGKDVWMP-VTSAS 16966
Query: 655 GSDHVMLKSLDWNAEYEVYVVAENQQGKS 683
+ L +Y + AEN G S
Sbjct: 16967 AKTTCKVSKLLEGKDYIFRIHAENLYGIS 16995
Score = 49.7 bits (117), Expect = 1e-05
Identities = 91/375 (24%), Positives = 141/375 (37%), Gaps = 58/375 (15%)
Query: 81 LTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCD 140
LT+ N DD G Y GE+ + + TV K + T Q E ++AV C+
Sbjct: 2589 LTVLNMMKDDEGKYT-FYAGENMTSGKLTVAGGAISKPL-----TDQTVAESQEAVFECE 2642
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 200
V + W G+ + L ++R + I K D+ GE
Sbjct: 2643 VANP-DSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATKLDD-----------IGEYT 2690
Query: 201 FKDIQVIVNVPPTIQA---RQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+K + ++A ++ + N T Q + + W K+G +E
Sbjct: 2691 YKVATSKTSAKLKVEAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLES- 2749
Query: 258 EDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHL-----KVFAKPK- 309
+EKY S + L IK DE+ Y + G A+ L K+ KPK
Sbjct: 2750 --NEKYAISVKGTIYSLRIKNCAIVDESVY----GFRLGRLGASARLHVETVKIIKKPKD 2803
Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
+T +EN T V S D +P + W S E K D H +V S +V
Sbjct: 2804 VTALENAT-------VAFEVSVSHDTVP-VKWFHK----SVEIKPSDKHRLV-SERKVHK 2850
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEV- 428
L L++I +DAGEY + +++E + K + V E + CEV
Sbjct: 2851 LMLQNISPSDAGEYTAVVGQL--ECKAKLFVETLHITKTMKNIEVP--ETKTASFECEVS 2906
Query: 429 -FAYPSATISWFRDG 442
F PS W ++G
Sbjct: 2907 HFNVPS---MWLKNG 2918
Score = 49.7 bits (117), Expect = 1e-05
Identities = 102/466 (21%), Positives = 168/466 (36%), Gaps = 28/466 (6%)
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAE 290
+T++ + G+P PT +W G+++ + D K ++L I +++D+ Y E
Sbjct: 13412 ITILVPSTGYPRPTATWC-FGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLE 13470
Query: 291 NKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDP--IPSITWRTSTRNI 348
N+ I + V A+P E + ++ V LT E D P + R +
Sbjct: 13471 NRVKTISGEIDVNVIARPSAP-KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREV 13529
Query: 349 SSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY---LEVQYA 405
S + T V V L +Q + +C A N G + + +
Sbjct: 13530 SRKTWTKVMDFVTDLEFTVPDL----VQGKEYLFKVC-ARNKCGPGEPAYVDEPVNMSTP 13584
Query: 406 PKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLL---PSSNYSNIKIYNTPSAS 462
+ P W N + P G ++ P + + + +
Sbjct: 13585 ATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAET 13644
Query: 463 YLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQA-DTPSSPSI----DQVEPYSSTA 515
+EVT E + Y A+NR G + S +QA DT +P I + + A
Sbjct: 13645 KMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKA 13704
Query: 516 QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVR 575
+ + P G P + K W + K + + VTIV K T
Sbjct: 13705 GTKIELPATVTGKP--EPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYI 13762
Query: 576 LAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHY 635
+ A+N G +A E G P+A + E + + +DDGGS I +Y
Sbjct: 13763 IEAVN--VCGRATAVVEVNVLDKPGPPAAFDITDVTNE--SCLLTWNPPRDDGGSKITNY 13818
Query: 636 LVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681
+V RA SE ++ + L N EY V AEN G
Sbjct: 13819 VVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIFRVAAENMYG 13864
Score = 49.3 bits (116), Expect = 2e-05
Identities = 96/438 (21%), Positives = 165/438 (37%), Gaps = 35/438 (7%)
Query: 23 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLT 82
DI+ ++ E VG S F C V+ I+ + +G + + + + D L
Sbjct: 11123 DIILTESEF-VGSSAIFECLVSPSTA---ITTWMKDGSNIRESPKHRFIA--DGKDRKLH 11176
Query: 83 IYNANIDDAGIYKCVV-TGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV 141
I + + DAG Y CV+ G S A + V+ K +G+ + C++
Sbjct: 11177 IIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCEL 11236
Query: 142 VSSLPPTIIWKHKGRDVILK--KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 199
+ ++W+ G+ V+ K + V ++ L I TD GTY +
Sbjct: 11237 --NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTY-----TVTVENA 11289
Query: 200 NFKDIQVIVNVPPTIQ--ARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
N + V V I+ + I + + CD P + W K ++I E
Sbjct: 11290 NNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDI-AKDTPNIKWFKGYDEIPAE 11348
Query: 258 EDDEKYIFSDDSS-QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
+D+ I D + L IK D AEY E K A + L + +E+
Sbjct: 11349 PNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGK--RYPAKLTLGEREVELLKPIEDV 11406
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
T E +E + E S IP W+ + E +++ LTL ++
Sbjct: 11407 TIYE-KESASFDAEISEADIPG-QWK-----LKGELLRPSPTCEIKAEGGKRFLTLHKVK 11459
Query: 377 YTDAGEYICTASNTIGQDSQSM-YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
AGE + A N I ++ +E+ +A L+ V E Q C + A
Sbjct: 11460 LDQAGEVLYQALNAITTAILTVKEIELDFAVPLKD---VTVPERRQARFECVLTR--EAN 11514
Query: 436 ISWFRDGQLLPSSNYSNI 453
+ W + ++ SS+ +I
Sbjct: 11515 VIWSKGPDIIKSSDKFDI 11532
Score = 48.5 bits (114), Expect = 3e-05
Identities = 66/279 (23%), Positives = 108/279 (38%), Gaps = 44/279 (15%)
Query: 326 TLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
T+T G P+P++ W S + L V + +SLT+++ D+G+Y
Sbjct: 26205 TMTVPFRGRPVPNVLW-------SKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 386 TASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDG 442
T N + S ++ ++V P G NIT + SA +SW DG
Sbjct: 26258 TIQNVLSAASLTLVVKVLDTP------------GPPTNITVQDVTKESAVLSWDVPENDG 26305
Query: 443 QLLPSSNY----------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QE 488
P NY + + + N + +VT E + + N G E
Sbjct: 26306 G-APVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAE 26364
Query: 489 SLEFILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
+ E + + + PS P V S + + + +PE GG I+ Y E G++ W
Sbjct: 26365 TKEGVKI-TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNW-V 26422
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
K AK + GL+ + Y R+ A N GL +
Sbjct: 26423 KCAVAKSTHH----VVSGLRENSEYFFRVFAENQAGLSD 26457
Score = 47.8 bits (112), Expect = 4e-05
Identities = 75/343 (21%), Positives = 138/343 (40%), Gaps = 32/343 (9%)
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
E+ + D L ++ V+ +E I+EN + KP I + +
Sbjct: 14347 EEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPD-------CKPTIDLETHDIIVI 14399
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
E++++ P+P+++W + + + ++ + + +H V KS++ DA
Sbjct: 14400 EGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVP----KSVR-ADA 14454
Query: 381 GEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT--ISW 438
G Y T N +G + S+ ++V P + + +T E + T + +
Sbjct: 14455 GIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHY 14514
Query: 439 FRDGQLLPSSNYSNIKI-YNTPSASYLEVTPDSENDFGNYNCTAVNRI-GQESLEF---- 492
+ + Y + N S + ++ P+ E F AVN++ G E +E
Sbjct: 14515 VLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFF---RVKAVNKVGGGEYIELKNPV 14571
Query: 493 ILVQADTPSSPSIDQVEPYSSTAQ---VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549
I P P +D VE ++ TA+ + + P GG I+ Y E A GEE +W
Sbjct: 14572 IAQDPKQPPDPPVD-VEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEE----RW 14626
Query: 550 YDAKEASMEGIV-TIVGLKPETTYAVRLAALNGKGLGEISAAS 591
E + + T GL+ Y R+ A N G+ E S A+
Sbjct: 14627 KRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRAT 14669
Score = 47.8 bits (112), Expect = 4e-05
Identities = 35/118 (29%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKD 250
G I AR E++ I + TI +V+A G+S + D G P PT+ W K
Sbjct: 22530 GAITARDEVDPPRISMDPKYKDTI-----VVHA----GESFKVDADIYGKPIPTIQWIKG 22580
Query: 251 GEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+++ E +D ++ L++K + D YI A+N AGE+ T+++KV +P
Sbjct: 22581 DQELSNTARLE-IKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRP 22637
Score = 47.8 bits (112), Expect = 4e-05
Identities = 25/85 (29%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 224 TANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEA 283
T G S+ L+ G P P ++W+K G + + ++ S L + KV++ D
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDT---TESYSLLIVDKVNRYDAG 29513
Query: 284 EYICIAENKAGEQDATIHLKVFAKP 308
+Y AEN++G++ AT+ +KV+ P
Sbjct: 29514 KYTIEAENQSGKKSATVLVKVYDTP 29538
Score = 47.4 bits (111), Expect = 6e-05
Identities = 69/332 (20%), Positives = 136/332 (40%), Gaps = 31/332 (9%)
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVT 326
+ + + ++K+ + E + A NKAG + A + + + K+ + +EL + +
Sbjct: 22894 NKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIIN 22953
Query: 327 LTCEAS--------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+ S G P P + W I ++ + +SL L ++
Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAA-------IIDVTSSFTSLVLDNVNRY 23006
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCE--VFAYPSATI 436
D+G+Y T N+ G S + + V P + V + V+IT E + S
Sbjct: 23007 DSGKYTLTLENSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIK 23066
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEF 492
++ + + +Y+ + + N S+ ++ E + TA N G ++ +
Sbjct: 23067 NYIVEKREATRKSYAAV-VTNCHKNSW-KIDQLQEGCSYYFRVTAENEYGIGLPAQTADP 23124
Query: 493 ILVQADTPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYD 551
I V A+ P P V+ + ++ + + +PE GG I++Y E +A E W
Sbjct: 23125 IKV-AEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSE---C 23180
Query: 552 AKEASMEGIVTIVGLKPETTYAVRLAALNGKG 583
A+ S++ ++T L Y R+ A+N KG
Sbjct: 23181 ARVKSLQAVIT--NLTQGEEYLFRVVAVNEKG 23210
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 4/193 (2%)
Query: 120 FKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKK-DVRFIVLSNNYLQIRG 178
FK R +A +VC V P + W +G+++I R Y Q+
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 179 IKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVN---ATANLGQSVTLVC 235
TD+ + R +G + V VP I + + A G+ V++
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049
Query: 236 DAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGE 295
G P+P ++W K + I+ + + +S + V++ D Y+ A+N+ G
Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI 31109
Query: 296 QDATIHLKVFAKP 308
T+ L V P
Sbjct: 31110 DQKTVELDVADVP 31122
Score = 47.0 bits (110), Expect = 7e-05
Identities = 89/415 (21%), Positives = 161/415 (38%), Gaps = 61/415 (14%)
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY----- 263
++PP+I ++ + G +V +V +G P PT++W K + ++ Y
Sbjct: 16115 DMPPSIDLKEFM---EVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVN 16171
Query: 264 -IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTAME 320
+ DD+ L I + ++D Y A N G + L V + P + ++ ++
Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 16231
Query: 321 LEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA 380
+Q+TL+ D S + + I E + V S + + T+ + +
Sbjct: 16232 --DQMTLSWFPPKDDGGS---KITNYVIEKREANRKTWVHVSSEPKECTYTIPKL--LEG 16284
Query: 381 GEYI--CTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW 438
EY+ A N G + + E + A L ++ G T S T++W
Sbjct: 16285 HEYVFRIMAQNKYGI-GEPLDSEPETARNL------FSVPGAPDKPTVSSVTRNSMTVNW 16337
Query: 439 FR---DGQLLPSSNYSNIKIYNTPSASYLEVTPD-------------------SENDFGN 476
DG P + Y +++ +T S + V D S+ F
Sbjct: 16338 EEPEYDGGS-PVTGYW-LEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRV 16395
Query: 477 YNCTAVNRIGQESLEFILVQAD---TPSSPSIDQVEPYS-STAQVQFDEPEATGGVPILK 532
Y A +G SL A P P +V ++ S+A +++ P GG +
Sbjct: 16396 YAINAAG-VGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTG 16454
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGI-VTIVGLKPETTYAVRLAALNGKGLGE 586
Y E++ G+E +W K+ + G + + GLK Y R+ A+N G+GE
Sbjct: 16455 YIVEYKEEGKE----EWEKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGE 16505
Score = 47.0 bits (110), Expect = 7e-05
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
I R ++ I+V V T+ I+ A G++ L D G P PTM W+KDG+
Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTV-----ILKA----GEAFRLEADVSGRPPPTMEWSKDGK 21500
Query: 253 QIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
++E E I +D S+ L K + D Y A N G ++KV +P
Sbjct: 21501 ELEGTAKLEIKI-ADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRP 21555
Score = 47.0 bits (110), Expect = 7e-05
Identities = 96/520 (18%), Positives = 194/520 (37%), Gaps = 40/520 (7%)
Query: 210 VPPTIQARQNIVNA-TANLGQSVTLVCDAEGFPEPTMSWTKD-GEQIEQEEDDEKYIFSD 267
+PP I+ ++ T ++ L +G P P + W +D GE +++ + +
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIES----TS 21911
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
+ L + V++ D +YI EN +G + A ++++V P ++++E
Sbjct: 21912 SYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP-----GPPQDLKVKEVTKT 21966
Query: 328 TCEASGDPIPSITWRTSTRN--ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC 385
+ + DP P + + +N + E T + V ++ +S + +Q + +
Sbjct: 21967 SVTLTWDP-PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRV 22025
Query: 386 TASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYP--SATISWFR 440
A N G + ++ P G + + N V+++ E + S + +
Sbjct: 22026 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 22085
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG---QESLEFILVQA 497
+ Q S ++ A+ + E F +A N G L ++
Sbjct: 22086 EMQTKGSDKWATCATVKVTEATITGLIQGEEYSF---RVSAQNEKGISDPRQLSVPVIAK 22142
Query: 498 DTPSSPSIDQV-EPYSSTA--QVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKE 554
D P+ + ++ A ++ D P P + W + + +A+
Sbjct: 22143 DLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAV----TWHKDNVPLKQTTRVNAES 22198
Query: 555 ASMEGIVTIVGLKPETT--YAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMG 612
++TI E Y V+L G+ + ++ K G P+ P ++
Sbjct: 22199 TENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDK----PGPPTGPVKMDEVT 22254
Query: 613 EDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEV 672
D ++ K DGGS I +Y+V R S+ + + L EY+
Sbjct: 22255 ADSITLSWGPPKY-DGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQF 22313
Query: 673 YVVAENQQGKSKAAHFVFRTSAQPTAIPA-NGSPTSGLST 711
+ AEN+ GKS + + P +P G+P LS+
Sbjct: 22314 RIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSS 22353
Score = 46.2 bits (108), Expect = 1e-04
Identities = 95/398 (23%), Positives = 149/398 (37%), Gaps = 59/398 (14%)
Query: 225 ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
A G ++ + G P+PT++W K G+QI ++ + + S+ L I + ++D
Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTW-KKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTS 344
Y A N GE I ++V P ++ +E + S DP P
Sbjct: 21136 YPLTARNIVGEVGDVITIQVHDIPG----PPTGPIKFDEVSSDFVTFSWDP-PENDGGVP 21190
Query: 345 TRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTASNT--IGQDSQSMYL 400
N E + D V V T K+ + T EY A N +G S +
Sbjct: 21191 ISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACI 21250
Query: 401 EVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNY------S 451
Y K+ GP QV + S TISW DG P Y
Sbjct: 21251 VANYPFKVPGPPGT-----PQVTAVTK----DSMTISWHEPLSDGG-SPILGYHVERKER 21300
Query: 452 NIKIYNTPSASYL--EVTPDSENDFG---NYNCTAVNRIGQESLEFILVQADTPSSP--S 504
N ++ T S + + + S G + A N G+ + PS P +
Sbjct: 21301 NGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKS-------KPSKPSEPMLA 21353
Query: 505 IDQVEPYSS---------TAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
+D ++P T +++ +PE TGG I Y E R ++ + +W A +
Sbjct: 21354 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKR----DLPNGRWLKANFS 21409
Query: 556 S-MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
+ +E T+ GL + Y R+ A N G IS SE
Sbjct: 21410 NILENEFTVSGLTEDAAYEFRVIAKN--AAGAISPPSE 21445
Score = 45.8 bits (107), Expect = 2e-04
Identities = 92/421 (21%), Positives = 157/421 (37%), Gaps = 47/421 (11%)
Query: 210 VPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS 269
+PP + N A G+ + + G P P ++W KD ++Q ++++
Sbjct: 22146 IPPAFKLLFNTFTVLA--GEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAES-TENN 22202
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTC 329
S LTIK + D Y+ N AGE T+++ V KP ++++E +
Sbjct: 22203 SLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG----PPTGPVKMDEVTADSI 22258
Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY--ICTA 387
S P P +S N E++ A V+ T+K+ + EY A
Sbjct: 22259 TLSWGP-PKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 22317
Query: 388 SNTIGQDS--QSMYLEVQYAPKLQGP-----VAVYTWEGNQVNITCEVFAYPSATISWFR 440
N G+ + S QY K+ GP V + + + +V + S I +
Sbjct: 22318 ENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHL 22377
Query: 441 DGQLLPSSNYSNIKIYNTP------SASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ + S + +K+ TP + LE + E N + + + S ++
Sbjct: 22378 ERKERNSILW--VKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVA 22435
Query: 495 VQ-ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
D P P V S T +Q+ +P GG I Y E + + E W
Sbjct: 22436 RDPCDPPGRPEAIIVTRNSVT--LQWKKPTYDGGSKITGYIVEKKELPEGRW-------M 22486
Query: 554 EASMEGIV----TIVGLKPETTYAVRLAALNGKGL--------GEISAASEFKTQPVQGE 601
+AS I+ + GL + Y R+ A N G+ G I+A E + +
Sbjct: 22487 KASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMD 22546
Query: 602 P 602
P
Sbjct: 22547 P 22547
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 18/135 (13%)
Query: 176 IRGIKKTDEGTYRCE--GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
I G K D CE G I A + ++ + N T ++V A G S+ L
Sbjct: 28331 INGAGKGDS----CEVTGTIKAVDRLTAPELDIDANFKQT-----HVVRA----GASIRL 28377
Query: 234 VCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKA 293
+G P PT W+K + D +D S LT++ ++ND +Y EN +
Sbjct: 28378 FIAYQGRPTPTAVWSKPDSNLSLRADIHT---TDSFSTLTVENCNRNDAGKYTLTVENNS 28434
Query: 294 GEQDATIHLKVFAKP 308
G + T +KV P
Sbjct: 28435 GSKSITFTVKVLDTP 28449
Score = 45.1 bits (105), Expect = 3e-04
Identities = 62/275 (22%), Positives = 111/275 (40%), Gaps = 23/275 (8%)
Query: 419 GNQVNITCEVFAYPSATISWFRD-GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
G + I V P T W ++ G+L + + I N + S L + D G Y
Sbjct: 15119 GKTLRIPAVVTGRPVPTKVWTKEEGEL----DKDRVVIDNVGTKSELIIKDALRKDHGRY 15174
Query: 478 NCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQV---QFDEPEATGGVPILKYK 534
TA N G + + D P P +D ++P + ++ + +PE GG I +
Sbjct: 15175 VITATNSCGSKFAAARVEVFDVPG-PVLD-LKPVVTNRKMCLLNWSDPEDDGGSEITGFI 15232
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
E + W + + + + I GL Y R+ A N G G
Sbjct: 15233 IERKDAKMHTWRQP-IETERSKCD----ITGLLEGQEYKFRVIAKNKFGCGPPVEIGPIL 15287
Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIK-QDDGGSPIRHYLVRYRALSSEWKPEIRLP 653
G P++P+ ++I ++ + + +GGSPI+ Y++ R KP+
Sbjct: 15288 AVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEKRRHD---KPDFERV 15344
Query: 654 S----GSDHVMLKSLDWNAEYEVYVVAENQQGKSK 684
+ + ++++LD + YE V A N+ G+S+
Sbjct: 15345 NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESE 15379
Score = 43.9 bits (102), Expect = 6e-04
Identities = 58/247 (23%), Positives = 99/247 (40%), Gaps = 32/247 (12%)
Query: 476 NYNCTAVNRIGQ----ESLEFILVQADT--PSSPS-IDQVEPYSSTAQVQFDEPEATGGV 528
++ AVN+ G+ E + +L + PS P ++ + +TA +++ PE GG
Sbjct: 14054 SFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGS 14113
Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
PI Y E R V + W + K+ T+ L + Y R+AA N G + +
Sbjct: 14114 PITNYIVEKRDVRRKGWQTVDTTVKDTK----CTVTPLTEGSLYVFRVAAENAIGQSDYT 14169
Query: 589 AASEF----KTQPVQGEPSAPKLEGQMGEDGNSIKVNL---IKQDDGGSPIRHYLV-RYR 640
+ T G P A + D V+L ++DGG PI+ Y++ +
Sbjct: 14170 EIEDSVLAKDTFTTPGPPYALAV-----VDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKE 14224
Query: 641 ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIP 700
L + W + + + + E + V AEN+ G ++PT I
Sbjct: 14225 RLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENEAGVGH--------PSEPTEIL 14276
Query: 701 ANGSPTS 707
+ PTS
Sbjct: 14277 SIEDPTS 14283
Score = 43.9 bits (102), Expect = 6e-04
Identities = 89/401 (22%), Positives = 154/401 (38%), Gaps = 68/401 (16%)
Query: 288 IAENKAGEQD-ATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEASGDPIPS 338
+A N AGE D A + V K ++ E + +++ + + L+ G P P
Sbjct: 17190 LAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPK 17249
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
+TW+ R+ ++ + +D V S L +++ + D G Y T N G + S+
Sbjct: 17250 VTWKKEDRDAPTKAR-IDVTPVG------SKLEIRNAAHEDGGIYSLTVENPAGSKTVSV 17302
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLPSSNYSNIKI 455
+ V P G ++ S ++W DG + ++ +
Sbjct: 17303 KVLVLDKP------------GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRD 17350
Query: 456 YNTPSASYLEVTPDSENDF------GN---YNCTAVNRIGQ----ESLEFI--LVQADTP 500
+ S L T ++ F GN + A N+ G+ E+ + I L P
Sbjct: 17351 VASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPP 17410
Query: 501 SSPS-IDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + V+ + + +++P+ GG PI Y E++ G + W ++E
Sbjct: 17411 GPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKF---KTVTNLEC 17467
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG----EISAASEFKTQPVQGEPSAPKLEGQMGEDG 615
+VT GL+ TY R+ A N GLG I + K P E +EG + + G
Sbjct: 17468 VVT--GLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAG 17525
Query: 616 NSIK---------VNLIKQDDGGSPIR---HYLVRYRALSS 644
+++ V K GS I+ HY V SS
Sbjct: 17526 TTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS 17566
Score = 43.1 bits (100), Expect = 0.001
Identities = 87/443 (19%), Positives = 174/443 (39%), Gaps = 57/443 (12%)
Query: 14 LGTAVSLQVD---IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRIS 70
LG + L V+ I+ +++ E+ +V+ + WF + E ++ R+
Sbjct: 2784 LGASARLHVETVKIIKKPKDVTALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLV 2843
Query: 71 VVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFR 130
++ L + N + DAG Y VV G+ +++ V K M KN P
Sbjct: 2844 ---SERKVHKLMLQNISPSDAGEYTAVV-GQLECKAKLFVETLHITKTM-KNIEVP---- 2894
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN-NYLQIRGIKKTDEGTYRC 189
E + A C+V P++ W G ++ + + + +V + L I D Y
Sbjct: 2895 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTF 2953
Query: 190 EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTK 249
+ +++ + P I + +NA + + + EG + W K
Sbjct: 2954 ---VCGNDQVS----ATLTVTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLK 3003
Query: 250 DGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPK 309
+G +I+ + + S L I+ V D A+Y +A AT++++
Sbjct: 3004 NGVEIKSTDKCQMRTKKLTHS-LNIRNVHFGDAADYTFVAGKATST--ATLYVEARHIEF 3060
Query: 310 ITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS 369
++++ +E +++ CE S +P ++ W +E + + ++ V
Sbjct: 3061 RKHIKDIKVLE-KKRAMFECEVS-EPDITVQWMKD-----DQELQITDRIKIQKEKYVHR 3113
Query: 370 LTLKSIQYTDAGEYICTASNTI--------GQD--SQSMYLEVQYAPKLQGPVAVYTWEG 419
L + S + +DAG+Y A + G+D +S+ EVQ K + AV +E
Sbjct: 3114 LLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQR---AVVEFEV 3170
Query: 420 NQVNITCEVFAYPSATISWFRDG 442
N+ ++ W++DG
Sbjct: 3171 NEDDVDAH----------WYKDG 3183
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD--SSQLTIKKVDKNDEAEY 285
G+ +++ P PT+SW KDG++++ ++ +D S+ L + K + D Y
Sbjct: 14401 GEKLSIPVPFRAVPVPTVSWHKDGKEVKA---SDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 286 ICIAENKAGEQDATIHLKVFAKP 308
ENK G A+I++KV P
Sbjct: 14458 TITLENKLGSATASINVKVIGLP 14480
Score = 43.1 bits (100), Expect = 0.001
Identities = 70/335 (20%), Positives = 110/335 (32%), Gaps = 47/335 (14%)
Query: 405 APKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSN------------ 452
APK+ ++ G+++ + + P TI+W +D ++
Sbjct: 14680 APKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVIVPEEIKKRAAPLVRRRKGE 14739
Query: 453 --------------IKIYNTPSA-SYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQA 497
+ I N+ S L V D G Y N G +
Sbjct: 14740 VQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYMIKVENDHGIAKAPCTVSVL 14799
Query: 498 DTPSSPSIDQVEPYSSTAQV-QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEAS 556
DTP P E T+ + +++ P GG I+ Y E + + S+W
Sbjct: 14800 DTPGPPINFVFEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKP--DSEWIVVTSTL 14857
Query: 557 MEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN 616
++ L Y R+ A N G G + + G P AP N
Sbjct: 14858 RHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSN 14917
Query: 617 SIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVA 676
S+ V + D GSPI Y + R ++S + KSL + +
Sbjct: 14918 SMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVN----------KSL-------LNALK 14960
Query: 677 ENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLST 711
N G + +VFR A+ A P SP S T
Sbjct: 14961 ANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKT 14995
Score = 43.1 bits (100), Expect = 0.001
Identities = 95/483 (19%), Positives = 174/483 (36%), Gaps = 60/483 (12%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G S + +G P P ++W+++ + + EK + + +QL+I D+ND +YI
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGV---NYTQLSIDNCDRNDAGKYIL 24095
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMEL-EEQVTLTCEASGDPIPSITWRTSTR 346
EN +G + A + +KV P +N E+ ++ L E P I +
Sbjct: 24096 KLENSSGSKSAFVTVKVLDTPGPP--QNLAVKEVRKDSAFLVWEP-----PIIDGGAKVK 24148
Query: 347 N--ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQY 404
N I E T + V S +S ++++ + A N G ++
Sbjct: 24149 NYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVK 24208
Query: 405 APKLQGPVAVYT------------WEGNQVNITCEVFAY-----PSATISWFRDGQLLPS 447
A + P T WE + + V Y P T W ++
Sbjct: 24209 AAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKW----SIVAE 24264
Query: 448 SNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ 507
S N + S + + N+ G + L ++ D PS+
Sbjct: 24265 SKVCNAVVTGLSSGQEYQFRVKAYNEKG--------KSDPRVLGVPVIAKDLTIQPSLKL 24316
Query: 508 VEPYSSTAQVQFDEPEATGGVPIL---KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV 564
P+ +T +Q E + +P++ + W GE + + + +E + ++ I
Sbjct: 24317 --PF-NTYSIQAGE-DLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIK 24372
Query: 565 GLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIK 624
+ + A N G A+E + V +P P G + D S +I
Sbjct: 24373 EGNKDDFGKYTVTATNSAG-----TATENLSVIVLEKPGPP--VGPVRFDEVSADFVVIS 24425
Query: 625 QD----DGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 680
+ GG I +Y+V R ++ + + + L EY+ + AEN+
Sbjct: 24426 WEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRY 24485
Query: 681 GKS 683
GKS
Sbjct: 24486 GKS 24488
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 24/150 (16%)
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
N ++ + + ++ +EN+ G +G S ++ + P+SP ++ +
Sbjct: 14242 NFRVTDVIEGTEVQFQVRAENEAG---------VGHPSEPTEILSIEDPTSPPSPPLDLH 14292
Query: 512 SSTA-----QVQFDEPEATGGVPILKYKAEWRAVGEEVW----HSKWYDAKEASMEGIVT 562
+ A + + PE GG PI+ Y E VG E W D K EG+V
Sbjct: 14293 VTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVV- 14351
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASE 592
P+ Y +R+ A+N G+ E S SE
Sbjct: 14352 -----PDKEYVLRVRAVNAIGVSEPSEISE 14376
Score = 42.4 bits (98), Expect = 0.002
Identities = 87/468 (18%), Positives = 169/468 (36%), Gaps = 32/468 (6%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G S+ + +G P P ++WTKD ++ + E ++ + L I + ++ D +++
Sbjct: 20791 GLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIEN---TESFTLLIIPECNRYDTGKFVM 20847
Query: 288 IAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRN 347
EN AG++ ++++V P T + ++ VTL + +P I + N
Sbjct: 20848 TIENPAGKKSGFVNVRVLDTPGPVLNLRPTDI-TKDSVTLHWD-----LPLIDGGSRITN 20901
Query: 348 ISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMYLEVQYA 405
E++ + + T K ++ EY A N G + E A
Sbjct: 20902 YIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 20961
Query: 406 PKLQGPVAVYTWEGNQVNITCEV--FAYP-------SATISWFRDGQLLPSSNYSNIKIY 456
+ P N ++IT A+P S + + Q S +++I
Sbjct: 20962 SEAPSPPDSL----NIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV 21017
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQ 516
+T E F + R ++V+ T P +D Y
Sbjct: 21018 KGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT-MLPELDLRGIYQKLVI 21076
Query: 517 VQFDEPEATGGVPIL---KYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYA 573
+ + +P+L K W+ + + ++ + + + I+ I +
Sbjct: 21077 AKAGD-NIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGP 21135
Query: 574 VRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIR 633
L A N +GE+ + + G P+ P ++ D + + ++DGG PI
Sbjct: 21136 YPLTARN--IVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWD-PPENDGGVPIS 21192
Query: 634 HYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681
+Y+V R S E+ L EY+ V A+N+ G
Sbjct: 21193 NYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYG 21240
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/209 (23%), Positives = 89/209 (42%), Gaps = 14/209 (6%)
Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD 267
+ + P+++ N + A G+ + + G P P +SW KDGE ++Q +
Sbjct: 24308 LTIQPSLKLPFNTYSIQA--GEDLKIEIPVIGRPRPNISWVKDGEPLKQ-TTRVNVEETA 24364
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S+ L IK+ +K+D +Y A N AG + + V KP + + V +
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424
Query: 328 TCEASGDPIPSITWRTSTRNISSEEK---TLDGHMVVRSHARVSSLTLKSIQYTDAGEYI 384
+ E P+ T N E++ T HMV + AR +++ + ++ ++
Sbjct: 24425 SWEP-----PAYTGGCQISNYIVEKRDTTTTTWHMVSATVAR-TTIKITKLKTGTEYQFR 24478
Query: 385 CTASNTIGQDS--QSMYLEVQYAPKLQGP 411
A N G+ + S + VQY K GP
Sbjct: 24479 IFAENRYGKSAPLDSKAVIVQYPFKEPGP 24507
Score = 42.4 bits (98), Expect = 0.002
Identities = 59/273 (21%), Positives = 101/273 (36%), Gaps = 22/273 (8%)
Query: 419 GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 478
G V + P+A + W+ +G L S S I NT LE+ +D G Y
Sbjct: 32388 GQNTRFILNVQSKPTAEVKWYHNGVELQES--SKIHYTNTSGVLTLEILDCHTDDSGTYR 32445
Query: 479 CTAVNRIGQES----LEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYK 534
N G+ S L+ T +S D+ P S ++ E A
Sbjct: 32446 AVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPRSVFPELTRTEAYAV--------- 32496
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
+ ++ E S + K E ++ + + ++ AAL K L E S + K
Sbjct: 32497 SSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIK 32556
Query: 595 TQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH--YLVRYRALSSEWKPEIRL 652
T + P+ +G S + + D G P+ +L + + LS+ + ++
Sbjct: 32557 TTLAARILTKPR--SMTVYEGESARFSC---DTDGEPVPTVTWLRKGQVLSTSARHQVTT 32611
Query: 653 PSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKA 685
+ S+ + E VV EN +GK +A
Sbjct: 32612 TKYKSTFEISSVQASDEGNYSVVVENSEGKQEA 32644
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GEI DIQ V I A+ +V G + + +G P P SW DG+ +
Sbjct: 15797 GEIPATDIQEEPEVFIDIGAQDCLV---CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKA 15853
Query: 257 EED-------DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+D D + +++SS + I + ++ +Y A+NKAG++ A +KV P
Sbjct: 15854 MKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVP 15912
Score = 42.0 bits (97), Expect = 0.002
Identities = 78/367 (21%), Positives = 139/367 (37%), Gaps = 61/367 (16%)
Query: 253 QIEQEEDDEKYIFSDDS----SQLTIKKVDKNDEAEYICIAENKAG-EQDATIHLKVFAK 307
+I E+DE I + + + TI + +N E + A N G + A + A+
Sbjct: 21793 EIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAE 21852
Query: 308 PKITYVENQTAMELEEQVTLTC--------EASGDPIPSITWRTSTRNISSEEKTLDGHM 359
++ E + +L + VT+ G P P + W ++LD
Sbjct: 21853 DRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARD------HGESLD-KA 21905
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEG 419
+ S + + L + ++ D+G+YI T N+ G S + + V P G
Sbjct: 21906 SIESTSSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTP------------G 21953
Query: 420 NQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY-----NTPSASYLEVTPDSEN-- 472
++ + S T++W D LL S IK Y + +Y V +
Sbjct: 21954 PPQDLKVKEVTKTSVTLTW--DPPLLDGG--SKIKNYIVEKRESTRKAYSTVATNCHKTS 22009
Query: 473 ---DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQ----------VEPYSSTAQVQF 519
D C+ R+ E+ I + A+T S + ++ ++ + +
Sbjct: 22010 WKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSW 22069
Query: 520 DEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAAL 579
++PE GG IL Y E + G + KW + TI GL Y+ R++A
Sbjct: 22070 EKPEHDGGSRILGYIVEMQTKGSD----KWATCATVKVTE-ATITGLIQGEEYSFRVSAQ 22124
Query: 580 NGKGLGE 586
N KG+ +
Sbjct: 22125 NEKGISD 22131
Score = 41.6 bits (96), Expect = 0.003
Identities = 89/449 (19%), Positives = 165/449 (36%), Gaps = 66/449 (14%)
Query: 33 VGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAG 92
+GE+ CQ+ G DI W+ E + + ++S +D + TLT+ +D G
Sbjct: 30546 LGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMS---SDGRTHTLTVMTEEQEDEG 30601
Query: 93 IYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDV--VSSLPPTII 150
+Y C+ T E G ++ + P +++ + + V + P +
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMT 30661
Query: 151 WKHKGRDVILKKDVRFIVLSNNY--LQIRGI-KKTDEGTYRCEGRILARGEINFKDIQVI 207
W H G+ ++ + I + +Y L ++ + +KT G Y+ + +
Sbjct: 30662 WFH-GQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ----------------L 30704
Query: 208 VNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSW---TKDG---------EQIE 255
NV T+ A ++ + +V +A +SW DG E+ E
Sbjct: 30705 SNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCE 30764
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYI--CIAENKAGEQD------ATIHLKVFAK 307
+E E + S S T + V+ + A Y A+N G D I F K
Sbjct: 30765 AKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEK 30824
Query: 308 PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSH 364
P TA+ + +C + P P+ RN E+K V
Sbjct: 30825 PGAPGKPTITAVTKD-----SCVVAWKP-PASDGGAKIRNYYLEKREKKQNKWISVTTEE 30878
Query: 365 ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV--YTWEGNQV 422
R + ++K++ E+ N +G +S+ + PK P+ + E +
Sbjct: 30879 IRETVFSVKNLIEGLEYEFRVKCEN-LGGESEWSEISEPITPKSDVPIQAPHFKEELRNL 30937
Query: 423 NI--------TCEVFAYPSATISWFRDGQ 443
N+ C+V +P + W+R G+
Sbjct: 30938 NVRYQSNATLVCKVTGHPKPIVKWYRQGK 30966
Score = 41.2 bits (95), Expect = 0.004
Identities = 99/457 (21%), Positives = 165/457 (36%), Gaps = 67/457 (14%)
Query: 162 KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV 221
K +F V + N + + + + EG Y + ++L PP I + I
Sbjct: 18867 KKYKFRVAARNAVGV-SLPREAEGVYEAKEQLL----------------PPKILMPEQI- 18908
Query: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281
T G+ + + G P PT W K +++ + +D SS L IK V + D
Sbjct: 18909 --TIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHK-ADSSSILIIKDVTRKD 18965
Query: 282 EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITW 341
Y AEN +G I + V P Q ++ + C S IP
Sbjct: 18966 SGYYSLTAENSSGTDTQKIKVVVMDAPG----PPQPPFDISDIDADACSLSWH-IPLEDG 19020
Query: 342 RTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI--CTASNTIGQDSQSMY 399
++ N E+ + V + A V+ + + + EYI A N G
Sbjct: 19021 GSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFG------I 19074
Query: 400 LEVQYAPKL--QGPVAVYTWEGN----QVNITCEVFAYP-------SATISWF-----RD 441
E +PK+ Q P V + N +VN C A+ S I + R+
Sbjct: 19075 SEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERN 19134
Query: 442 GQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG----QESLEFILVQ- 496
L +N + ++ P A +E E F Y A+N+ G + E++ +
Sbjct: 19135 SLLWVKANDTLVRSTEYPCAGLVE---GLEYSFRIY---ALNKAGSSPPSKPTEYVTARM 19188
Query: 497 -ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEA 555
D P P + ++ ST + + P+ GG I+ Y E + + W + A
Sbjct: 19189 PVDPPGKPEV--IDVTKSTVSLIWARPKHDGGSKIIGYFVEACKLPGDKW-VRCNTAPHQ 19245
Query: 556 SMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
+ T GL+ + Y R A + S S+
Sbjct: 19246 IPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSD 19282
Score = 41.2 bits (95), Expect = 0.004
Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 464 LEVTPDSENDFGNYNCTAVNRIGQ----ESLEFILVQAD--TPSSPSIDQV-EPYSSTAQ 516
L+VT E + TAVN G E+ FI + TP PS +V + +
Sbjct: 29300 LKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSIS 29359
Query: 517 VQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRL 576
+ + +P GG I+ Y E + + W+ +A + E T+ LK Y+ R+
Sbjct: 29360 LAWTKPMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTE--FTVPDLKMGQKYSFRV 29417
Query: 577 AALNGKGLGEISAASEFKTQPVQ 599
AA+N KG+ E S S + +PV+
Sbjct: 29418 AAVNVKGMSEYS-ESIAEIEPVE 29439
Score = 40.8 bits (94), Expect = 0.005
Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%)
Query: 411 PVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
P V EG C V YP ++W+ +GQL+ S ++ YL++
Sbjct: 1847 PEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY---DGIHYLDIVDCK 1903
Query: 471 ENDFGNYNCTAVNRIG------------QESLEFILVQADTPSSPSIDQVEPYSSTAQVQ 518
D G TA N G +E +L +A P P EP +VQ
Sbjct: 1904 SYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEP-RPEFHVHEPGKLQFEVQ 1962
Query: 519 -FDEP-EATGGVPILKYKAEWRAVGEEV------WHSKWYDAKEASMEGIVTIVGLK 567
D P + T ++K K R E+V SK+ E +T V LK
Sbjct: 1963 KVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGYYEAITAVELK 2019
Score = 40.8 bits (94), Expect = 0.005
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 55/382 (14%)
Query: 81 LTIYNANIDDAG--IYKCVVTGEDGSESEATVNVKIFQ---KLMFKNAPTPQEFREGEDA 135
LT++ +D AG +Y+ + + + A + VK + + K+ P+ + +
Sbjct: 11453 LTLHKVKLDQAGEVLYQAL-----NAITTAILTVKEIELDFAVPLKDVTVPERRQARFEC 11507
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGR 192
V+ + +IW KG D+I D +F ++++ + L I + DEG Y E
Sbjct: 11508 VLTREA------NVIWS-KGPDIIKSSD-KFDIIADGKKHILVINDSQFDDEGVYTAE-- 11557
Query: 193 ILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGE 252
G+ K + ++ + + T G++ T VC+ + + W K+
Sbjct: 11558 --VEGK---KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELS-HEKMHVVWFKNDA 11611
Query: 253 QIEQEEDDEKYIFSDDSS--QLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPK 309
++ + S + +L +K+V +D ++ + + E +T LKV A P
Sbjct: 11612 KLHTSRT---VLISSEGKTHKLEMKEVTLDDISQI----KAQVKELSSTAQLKVLEADPY 11664
Query: 310 ITY-VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS 368
T + ++TA+E +E +TL CE S D +P + W I K +++
Sbjct: 11665 FTVKLHDKTAVEKDE-ITLKCEVSKD-VP-VKWFKDGEEIVPSPK-----YSIKADGLRR 11716
Query: 369 SLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ-YAPKLQGPV-AVYTWEGNQVNITC 426
L +K D GEY+C G D + V+ K++ P+ V + G +
Sbjct: 11717 ILKIKKADLKDKGEYVCDC----GTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEI 11772
Query: 427 EVFAYPSATISWFRDGQLLPSS 448
E+ + P W GQ L +S
Sbjct: 11773 EL-SEPDVHGQWKLKGQPLTAS 11793
Score = 40.4 bits (93), Expect = 0.007
Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 7/101 (6%)
Query: 211 PPTIQARQNIVNATANL-GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSD-- 267
PP ++ ++ + G+++ + G P PT WTK+ E E D ++ + +
Sbjct: 15101 PPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKE----EGELDKDRVVIDNVG 15156
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
S+L IK + D Y+ A N G + A ++VF P
Sbjct: 15157 TKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP 15197
Score = 40.0 bits (92), Expect = 0.009
Identities = 85/396 (21%), Positives = 155/396 (39%), Gaps = 90/396 (22%)
Query: 279 KNDEAEYICIAENKAGEQDAT-IHLKVFAKPKITYVENQTAMELEEQVTLTCEAS----- 332
++ + ++ A NK G D + + K + K + E + +L + + L +
Sbjct: 19656 EDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYV 19715
Query: 333 ---GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASN 389
G P P ITW S N++ ++ + ++S + L +++ DAG+YI T N
Sbjct: 19716 PVKGRPPPKITW--SKPNVNLRDRI---GLDIKSTDFDTFLRCENVNKYDAGKYILTLEN 19770
Query: 390 TIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISW---FRDGQLLP 446
+ G+ ++ ++V P G VN+T + + SA ++W DG P
Sbjct: 19771 SCGKKEYTIVVKVLDTP------------GPPVNVTVKEISKDSAYVTWEPPIIDGG-SP 19817
Query: 447 SSNY---------------------SNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRI 485
NY ++ ++ N +EN++G I
Sbjct: 19818 IINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYG---------I 19868
Query: 486 GQESLEFILVQADTPSSPSID-QVEPYS-STAQVQFDEPEATGGVPILKY-------KAE 536
G V+A P +D +V S S+ + + +P + GG I+ Y + +
Sbjct: 19869 GDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENK 19928
Query: 537 WRAVGEEVWHSKWYDAKEASMEGIVTI---------VGLKPETTYAVR----LAALNGKG 583
W+ V + + S Y AK+ + T G E T R L+ KG
Sbjct: 19929 WQRVMKSL--SLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKG 19986
Query: 584 LGEI----SAASEFKTQ-PVQGEPSAPKLEGQMGED 614
L ++ S F+ + P++G+P AP + + GED
Sbjct: 19987 LPDLCYLAKENSNFRLKIPIKGKP-APSVSWKKGED 20021
Score = 40.0 bits (92), Expect = 0.009
Identities = 29/150 (19%), Positives = 65/150 (43%), Gaps = 8/150 (5%)
Query: 166 FIVLSNNYLQIRGIKKTDEGTYRCEGR----ILARGEINFKDIQVIVNVPPT---IQARQ 218
+ ++S+N+ + + + D +R + ++++G + + P + AR
Sbjct: 28993 YTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL 29052
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVD 278
+ T G + L G PEP + WTK ++++ E ++ + IK D
Sbjct: 29053 HGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCE-KVSLQYTGKRATAVIKFCD 29111
Query: 279 KNDEAEYICIAENKAGEQDATIHLKVFAKP 308
++D +Y +N +G + ++ +KV P
Sbjct: 29112 RSDSGKYTLTVKNASGTKAVSVMVKVLDSP 29141
Score = 39.7 bits (91), Expect = 0.012
Identities = 79/392 (20%), Positives = 147/392 (37%), Gaps = 74/392 (18%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA----MELEEQV 325
+Q + + ++ + A N AG + + P + VE + A ++ E +
Sbjct: 20731 TQFVVPDLQTKEKYNFRISAINDAGVGEPAVI------PDVEIVEREMAPDFELDAELRR 20784
Query: 326 TLTCEAS----------GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
TL A G P P +TW N+ + + + + L +
Sbjct: 20785 TLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRAN-------IENTESFTLLIIPEC 20837
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
D G+++ T N G+ S + + V P GPV +N+ S T
Sbjct: 20838 NRYDTGKFVMTIENPAGKKSGFVNVRVLDTP---GPV---------LNLRPTDITKDSVT 20885
Query: 436 ISW--------FRDGQLLPSSNYSNIKIYNTPSASY----LEVTPDSENDFGNYNCTAVN 483
+ W R + + K Y+T + +VT SE + A N
Sbjct: 20886 LHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAEN 20945
Query: 484 RIG----QESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWR 538
G E+ E + ++ PS P S++ ++ ST + + +P+ GG I Y E +
Sbjct: 20946 EYGIGEPTETTEPVKA-SEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQ 21004
Query: 539 AVGEEVWHSKWYDAKEASMEGIVTIV-GLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
G + W +++G+ +V L Y ++ A+N G SA E +
Sbjct: 21005 RKGSDQW------THITTVKGLECVVRNLTEGEEYTFQVMAVNSAGR---SAPRESRPVI 21055
Query: 598 VQGEPSAPKLEGQ-------MGEDGNSIKVNL 622
V+ + P+L+ + + + G++IKV +
Sbjct: 21056 VKEQTMLPELDLRGIYQKLVIAKAGDNIKVEI 21087
Score = 39.3 bits (90), Expect = 0.016
Identities = 81/436 (18%), Positives = 157/436 (36%), Gaps = 66/436 (15%)
Query: 102 DGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILK 161
+G+ + T + K QK P P EGE A C V P + W G+ +++
Sbjct: 1825 EGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQ--LIR 1882
Query: 162 KDVRFIVLSN--NYLQIRGIKKTDEGTYRC-----EGRILARGEI------NFKDI---- 204
K RF V + +YL I K D G + EG I + ++ +F+ +
Sbjct: 1883 KSKRFRVRYDGIHYLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRA 1942
Query: 205 -----QVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE---Q 256
+ V+ P +Q V+ + ++ +V ++ E++ +
Sbjct: 1943 PEPRPEFHVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFK 2002
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDE-------------AEYICIAENKAGEQDATIHLK 303
+E Y + + +L +K D++ E + + E KA ++ I +
Sbjct: 2003 RRTEEGYYEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIP 2062
Query: 304 VFAKPKITYVENQTAMELEEQVT-----------LTCEASGDPIPSITWRTSTRNISSEE 352
F KI + A ++ E++ G P P W + I +
Sbjct: 2063 TFKPDKIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSD 2122
Query: 353 KTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ------YAP 406
+ V L ++ + D+ + A N G+ S +L VQ +
Sbjct: 2123 RI----YWYWPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQ 2178
Query: 407 KLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEV 466
+LQ VA + CE + P + W++DG + + ++++ +L +
Sbjct: 2179 ELQDVVA--KEKDTMATFECET-SEPFVKVKWYKDGMEVHEGD--KYRMHSDRKVHFLSI 2233
Query: 467 TPDSENDFGNYNCTAV 482
+D +Y+C V
Sbjct: 2234 LTIDTSDAEDYSCVLV 2249
Score = 38.9 bits (89), Expect = 0.020
Identities = 45/217 (20%), Positives = 86/217 (39%), Gaps = 13/217 (5%)
Query: 199 INFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEE 258
+ +D++V+ + + ++ I G+ V LV G P P SW G ++ + E
Sbjct: 29727 VTVQDLRVLPTIDLSTMPQKTI---HVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESE 29783
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+ ++LTI++ D EY +N G TI + + KP
Sbjct: 29784 RVTVETHT-KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG----PPTGP 29838
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
++++E + S +P P + E++ + V+ T K + T
Sbjct: 29839 IKIDEIDATSITISWEP-PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLT 29897
Query: 379 DAGEYICTASNT----IGQDSQSMYLEVQYAPKLQGP 411
+ EY+ + T IG QS +E + + ++ GP
Sbjct: 29898 EGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGP 29934
Score = 38.1 bits (87), Expect = 0.035
Identities = 47/204 (23%), Positives = 77/204 (37%), Gaps = 15/204 (7%)
Query: 117 KLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQI 176
K +F P + EG+ A VV P W H G+ ++ + ++ + +
Sbjct: 1456 KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSL 1515
Query: 177 RGIKKT--DEGTYRCEGRILARGEINFKDIQVIVNVPPT-IQARQNIVNATANL----GQ 229
+ T D G E ++A+ I VI+ V Q + V N+ G
Sbjct: 1516 IIVPATPSDSG----EWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGS 1571
Query: 230 SVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYI-FSDDSSQLTIKKVDKNDEAEYICI 288
+ + A G P P + W K+ + I + + I + + L I D A Y
Sbjct: 1572 RLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTAT 1631
Query: 289 AENKAGEQDATIHLKV---FAKPK 309
A NKAG + V FA+P+
Sbjct: 1632 AINKAGRDTTRCKVNVEVEFAEPE 1655
Score = 38.1 bits (87), Expect = 0.035
Identities = 95/438 (21%), Positives = 176/438 (40%), Gaps = 47/438 (10%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+ G F +V G D + W+ NG K+ RI W +D+ L I + +D
Sbjct: 2089 VGQGSDAHFRVRVVGKP-DPECEWYK-NGVKIE-RSDRIYWYWPEDNVCELVIRDVTAED 2145
Query: 91 AG--IYKCV-VTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP- 146
+ + K + + GE S + V K Q + F +E +D + + +S P
Sbjct: 2146 SASIMVKAINIAGETSSHAFLLVQAK--QLITFTQELQDVVAKE-KDTMATFECETSEPF 2202
Query: 147 PTIIWKHKGRDVILKKDVRFIVLSN---NYLQIRGIKKTDEGTYRCEGRILARGEINFKD 203
+ W G +V + ++ + S+ ++L I I +D Y C +L E
Sbjct: 2203 VKVKWYKDGMEV--HEGDKYRMHSDRKVHFLSILTIDTSDAEDYSC---VLVEDENVKTT 2257
Query: 204 IQVIVN--VPPTIQARQNIVNATANLGQSVTLVC--DAEGFPEPTMSWTKDGEQIEQEED 259
++IV V ++ Q+I + G+ +V + EG W + +E + +
Sbjct: 2258 AKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEG------KWYHN--DVELKSN 2309
Query: 260 DEKYIFSDDSSQ-LTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTA 318
+ I S Q LT+K V K D+ EY + + K T LK+ +P I ++ +
Sbjct: 2310 GKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK----KTTCKLKMKPRP-IAILQGLSD 2364
Query: 319 MELEEQ--VTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
++ E V L + S + + + W + + ++ H+V+ + + L ++ +
Sbjct: 2365 QKVCEGDIVQLEVKVSLESVEGV-WMKDGQEVQPSDRV---HIVIDKQSHM--LLIEDMT 2418
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATI 436
DAG Y T +G S S + V + V EG + + C+V ++
Sbjct: 2419 KEDAGNYSFTIP-ALGL-STSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDVTSV 2476
Query: 437 SWF-RDGQLLPSSNYSNI 453
W+ D Q+ P I
Sbjct: 2477 KWYLNDEQIKPDDRVQAI 2494
Score = 38.1 bits (87), Expect = 0.035
Identities = 94/418 (22%), Positives = 162/418 (38%), Gaps = 55/418 (13%)
Query: 238 EGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD 297
+G P P++SW K GE + S ++ L + K+D +Y +N AG ++
Sbjct: 20007 KGKPAPSVSWKK-GEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKE 20065
Query: 298 ATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG 357
TI +KV KP I T ++VT P + N E++
Sbjct: 20066 GTISIKVVGKPGI-----PTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVN 20120
Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNT----IGQDSQSMYLEVQY---APKLQG 410
+ V + V T + + + EY S +G+ +S + ++ P
Sbjct: 20121 NKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPP 20180
Query: 411 PVAVYTWEGNQVNITCEVFAYPSAT----ISWF------RDGQLLPSSNYSNIKIYNTPS 460
P + + V++T + P T I+ + R+ L +N + I++ +
Sbjct: 20181 PPNIVDVRHDSVSLT---WTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRD--- 20234
Query: 461 ASYLEVTPDSENDFGNYNCTAVN--RIGQESLEFILVQA----DTPSSPSIDQVEPYSST 514
+VT +E + A+N +G+ SL V A D P P + + S T
Sbjct: 20235 ---FKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVINITRNSVT 20291
Query: 515 AQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASM-EGIVTIVGLKPETTYA 573
+ + EP+ GG + Y E R ++ W A ++ E T+ L Y
Sbjct: 20292 --LIWTEPKYDGGHKLTGYIVEKR----DLPSKSWMKANHVNVPECAFTVTDLVEGGKYE 20345
Query: 574 VRLAALNGKGLGEISAASE-FKTQPVQGEPSAPKL-------EGQMGEDGNSIKVNLI 623
R+ A N G ISA SE +T + E AP + +G + G++I +N I
Sbjct: 20346 FRIRAKN--TAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAI 20401
Score = 37.0 bits (84), Expect = 0.077
Identities = 132/672 (19%), Positives = 229/672 (34%), Gaps = 95/672 (14%)
Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIF---- 115
EK + R S+ N DSSS LTI +D G Y + G +TV+VK+
Sbjct: 27309 EKNLGSDARYSIE-NTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVSVKVLDTPA 27367
Query: 116 --QKLMFKNAPTPQEFREGEDAVIVCD--VVSSLPPTIIWKHKGRDVILKKDVRFIVLSN 171
QKL K+ ++ D ++ P I + + RD K+ +
Sbjct: 27368 ACQKLQVKHVSRGT-------VTLLWDPPLIDGGSPIINYVIEKRDAT-KRTWSVVSHKC 27419
Query: 172 NYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSV 231
+ + I +++ + R+LA EI + + I + +
Sbjct: 27420 SSTSFKLIDLSEKTPFFF--RVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 27477
Query: 232 TLVCDAEGFPEPTMSWTK---DGEQIEQE---------EDDEKYIFSDDSSQLTIKKVDK 279
+++ +SWTK DG + E E + + ++ + ++ +
Sbjct: 27478 SVI----------LSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVSQLKE 27527
Query: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE--------NQTAMELEEQVTLTCEA 331
E+ A+N+ G D + K I E Q + + V L
Sbjct: 27528 QSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIGHNVHLELPY 27587
Query: 332 SGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTL--KSIQYTDAGEYICTASN 389
G P PSI+W + E VR + +TL K+ + G+Y N
Sbjct: 27588 KGKPKPSISWLKDGLPLKESE-------FVRFSKTENKITLSIKNAKKEHGGKYTVILDN 27640
Query: 390 TIGQDSQSMYLEVQYAP-KLQGPV---------AVYTWEGNQVN----ITCEVFAYPSAT 435
+ + + + + P K +GP+ + +W+ + N ITC ++
Sbjct: 27641 AVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGGEITC--YSIEKRE 27698
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
S + S + K+ N + + +EN +G + Q + I+V
Sbjct: 27699 TSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYG---------VSQPLVSSIIV 27749
Query: 496 Q------ADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKW 549
P P I V S + +D P GG + + E + +W K
Sbjct: 27750 AKHQFRIPGPPGKPVIYNVT--SDGMSLTWDAPVYDGGSEVTGFHVEKKERNSILW-QKV 27806
Query: 550 YDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEG 609
+ + E T GL Y R+ A N GL S S+F +P
Sbjct: 27807 NTSPISGREYRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYI 27864
Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAE 669
+ + ++K N + DGGS I Y + R + W + L
Sbjct: 27865 DVTRETITLKWNPPLR-DGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDR 27923
Query: 670 YEVYVVAENQQG 681
YE ++A N G
Sbjct: 27924 YEFRIIARNAVG 27935
Score = 36.6 bits (83), Expect = 0.10
Identities = 81/383 (21%), Positives = 136/383 (35%), Gaps = 65/383 (16%)
Query: 271 QLTIKKVDKNDEAEYICIAENKAGE---------------QDATIHLKVFAKPKITYVEN 315
Q T+K++ + + + A N AGE + + L V K I +
Sbjct: 15060 QYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAG 15119
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKS 374
+T + + +G P+P+ W + EE LD VV + S L +K
Sbjct: 15120 KT-------LRIPAVVTGRPVPTKVW-------TKEEGELDKDRVVIDNVGTKSELIIKD 15165
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
D G Y+ TA+N+ G + +EV P GPV +++ V
Sbjct: 15166 ALRKDHGRYVITATNSCGSKFAAARVEVFDVP---GPV---------LDLKPVVTNRKMC 15213
Query: 435 TISWF---RDG-----QLLPSSNYSNIKIYNTP---SASYLEVTPDSENDFGNYNCTAVN 483
++W DG + + + + P S ++T E + A N
Sbjct: 15214 LLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQEYKFRVIAKN 15273
Query: 484 RIG-QESLEFILVQADTPSSP-----SIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEW 537
+ G +E + A P P + E ST + + EP + GG PI Y E
Sbjct: 15274 KFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKSTITLDWKEPRSNGGSPIQGYIIEK 15333
Query: 538 RAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
R + + K + L Y R+ A+N G E S
Sbjct: 15334 RRHDKPDFERV---NKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNV---V 15387
Query: 598 VQGEPSAPKLEGQMGEDGNSIKV 620
+Q + P ++ ++ G++IKV
Sbjct: 15388 IQDDEVPPTIKLRLSVRGDTIKV 15410
Score = 36.6 bits (83), Expect = 0.10
Identities = 24/82 (29%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED-DEKYIFSDDSSQLTIKKVDKNDEAEYI 286
G ++ L +G P P ++W+K + D K +D + L + V+K D +YI
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKS--TDFDTFLRCENVNKYDAGKYI 19765
Query: 287 CIAENKAGEQDATIHLKVFAKP 308
EN G+++ TI +KV P
Sbjct: 19766 LTLENSCGKKEYTIVVKVLDTP 19787
Score = 36.6 bits (83), Expect = 0.10
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 5/82 (6%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDS-SQLTIKKVDKNDEAEYI 286
G S T+ G P P + W+K + Y+ + DS + LTI+ ++ND +Y
Sbjct: 26201 GASFTMTVPFRGRPVPNVLWSKPDTDLRTRA----YVDTTDSRTSLTIENANRNDSGKYT 26256
Query: 287 CIAENKAGEQDATIHLKVFAKP 308
+N T+ +KV P
Sbjct: 26257 LTIQNVLSAASLTLVVKVLDTP 26278
Score = 36.2 bits (82), Expect = 0.13
Identities = 52/239 (21%), Positives = 86/239 (35%), Gaps = 26/239 (10%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN----YLQIRGIKKTDEGT 186
EG A + P + W G+ VI + + +S + L I + K + G
Sbjct: 19 EGSTATFEAHISGFPVPEVSWFRDGQ-VISTSTLPGVQISFSDGRAKLTIPAVTKANSGR 77
Query: 187 YRCE-----GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
Y + G+ + E+ K PP Q + + T G V L G P
Sbjct: 78 YSLKATNGSGQATSTAELLVK----AETAPPNFV--QRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
P + + +DG +I Q D + D L I + D Y A N G +T
Sbjct: 132 TPVVKFYRDGAEI-QSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAE 190
Query: 302 LKVFAKPKITYVENQTAM---ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDG 357
L V + ++ + +T + ++ E E I R+I++ E +DG
Sbjct: 191 LLVQGEEEVPAKKTKTIVSTAQISESRQTRIE------KKIEAHFDARSIATVEMVIDG 243
Score = 35.8 bits (81), Expect = 0.17
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%)
Query: 14 LGTAVSLQVDIVPSQGE-------ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQ 66
L T+ L+++ P Q +S +S F C+V+ D D ++W+ E LT +Q
Sbjct: 8821 LETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSFD--DAIVTWYKGPTE-LTESQ 8877
Query: 67 QRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQK 117
+ ND +TI+N DD G+Y + E E+ +T + + K
Sbjct: 8878 KYN--FRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTK 8926
Score = 35.8 bits (81), Expect = 0.17
Identities = 116/552 (21%), Positives = 202/552 (36%), Gaps = 80/552 (14%)
Query: 34 GESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGI 93
G+ + C++ K++D+ W +G+ + RI V LTI +A+ DAG
Sbjct: 11227 GQPLYLSCELN---KERDVVW-RKDGKIVVEKPGRI-VPGVIGLMRALTINDADDTDAGT 11281
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y V + E + V V + Q + A+ CD+ P I W
Sbjct: 11282 YTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKD-TPNIKW-F 11339
Query: 154 KGRDVILKK--DVRFIVLSNN--YLQIRGIKKTDEGTYRCE---GRILARGEINFKDIQV 206
KG D I + D I+ N YL+I+ D Y E R A+ + +++++
Sbjct: 11340 KGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVEL 11399
Query: 207 IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFS 266
+ + + + A + ++ D G W GE + E I +
Sbjct: 11400 LKPIEDVTIYEKESASFDAEISEA-----DIPG------QWKLKGELLRPSPTCE--IKA 11446
Query: 267 DDSSQ-LTIKKVDKNDEAEYICIAEN---------KAGEQDATIHLKVFAKPKITYVENQ 316
+ + LT+ KV + E + A N K E D + LK +T E +
Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLK-----DVTVPERR 11501
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
A + LT EA ++ W I S +K + + + L + Q
Sbjct: 11502 QA---RFECVLTREA------NVIWSKGPDIIKSSDK-----FDIIADGKKHILVINDSQ 11547
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-WEGNQVNITCEVFAYPSAT 435
+ D G Y + G+ + + K P+ T EG CE+ ++
Sbjct: 11548 FDDEGVY---TAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMH 11603
Query: 436 ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV 495
+ WF++ L +S + I + LE+ + +D L+ ++
Sbjct: 11604 VVWFKNDAKLHTSR--TVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLK--VL 11659
Query: 496 QADTPSSPSIDQVEPYSSTAQVQFDE----PEATGGVPILKYKAEWRAVGEEVWHSKWYD 551
+AD + V+ + TA V+ DE E + VP+ +W GEE+ S Y
Sbjct: 11660 EADPYFT-----VKLHDKTA-VEKDEITLKCEVSKDVPV-----KWFKDGEEIVPSPKYS 11708
Query: 552 AKEASMEGIVTI 563
K + I+ I
Sbjct: 11709 IKADGLRRILKI 11720
Score = 35.8 bits (81), Expect = 0.17
Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 15/112 (13%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P +P + ++ S+ + +++P GG I Y E E+ W A +
Sbjct: 21759 PGNPRV--LDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATS- 21815
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQM 611
TI GL Y +R+ A+N +GLGE + P PK E +M
Sbjct: 21816 -YTITGLTENQEYKIRIYAMNSEGLGEPALV-----------PGTPKAEDRM 21855
Score = 35.4 bits (80), Expect = 0.22
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 626 DDGGSPIRHYLVRYR-ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGK 682
DDGGS I +Y+V R S++W P H K L+ +Y V AENQ G+
Sbjct: 17335 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSH-FAKHLNEGNQYLFRVAAENQYGR 17391
Score = 33.9 bits (76), Expect = 0.65
Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 6/93 (6%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
PS P I V+ +T + + +P GG PI Y E++ + W + +
Sbjct: 26087 PSKPKI--VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTE--- 26141
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
TI GL Y R+ ++N G + S +S+
Sbjct: 26142 -YTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173
Score = 33.5 bits (75), Expect = 0.85
Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 6/131 (4%)
Query: 585 GEISAASEFKTQPVQGEPSAPKLEG-QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALS 643
G+ +A K V G P K+ G S K+ DDGG I+ Y++ R +
Sbjct: 15898 GQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKM---PDDDGGDRIKGYVIEKRTID 15954
Query: 644 SEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANG 703
+ ++ GS ++ L +Y V AEN+ G + RT+A+ P +
Sbjct: 15955 GKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPD- 16013
Query: 704 SPTSGLSTGAI 714
P L G I
Sbjct: 16014 -PPIKLKIGLI 16023
Score = 33.5 bits (75), Expect = 0.85
Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 43/312 (13%)
Query: 40 LCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVT 99
+C+V G K + W+ G+++ + + + L I + DDA +Y+ T
Sbjct: 30948 VCKVTGHPKPI-VKWYR-QGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRAT 31005
Query: 100 GEDGSES-----EATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHK 154
+ GS S E V KI + R GE I P I W+ K
Sbjct: 31006 NQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALR-GEVVSIKIPFSGKPDPVITWQ-K 31063
Query: 155 GRDVILKKDVRFIVLSNNYLQI---RGIKKTDEGTYRCEGRILARGEINFKDIQV-IVNV 210
G+D+I ++++ ++ + G+++ D G Y + R I+ K +++ + +V
Sbjct: 31064 GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAK--NRFGIDQKTVELDVADV 31121
Query: 211 P------PTIQARQNIVNAT----ANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
P ++ VN T A+ G S E W + G+ E
Sbjct: 31122 PDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARE----- 31176
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME 320
++ T+ + ++ IAENK G + ++P IT + AM
Sbjct: 31177 ---------TRYTVINLFGKTSYQFRVIAENKFGLSKPSEP----SEPTITKEDKTRAMN 31223
Query: 321 LEEQVTLTCEAS 332
+E+V T E S
Sbjct: 31224 YDEEVDETREVS 31235
Score = 32.3 bits (72), Expect = 1.9
Identities = 67/287 (23%), Positives = 107/287 (37%), Gaps = 46/287 (16%)
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTP 500
DG+ L NY+NI+ +Y EVT +E+ + A N S +
Sbjct: 25728 DGRWL-KCNYTNIQ------ETYFEVTELTEDQRYEFRVFARNAADSVS------EPSES 25774
Query: 501 SSPSI--DQVEPYSSTAQVQFDEPEATGGVPILKYKAE----------WRAVGEEVWHSK 548
+ P I D VEP V+F + +LK A+ W G E+
Sbjct: 25775 TGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERA 25834
Query: 549 WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAP-KL 607
+ ++T+ T L N G ++ + +P G P+ P ++
Sbjct: 25835 RTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKP--GPPAGPLEI 25892
Query: 608 EGQMGEDGNSIKVNLI---KQDDGGSPIRHYLVRYRALSS-EW---KPEIRLPSGSDHVM 660
G E K +L Q+DGG+ I +Y+V R S W + E+++ S +
Sbjct: 25893 NGLTAE-----KCSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKL 25947
Query: 661 LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTS 707
LK EY V N+ G + V + P +P+ PTS
Sbjct: 25948 LK----GNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPS--PPTS 25988
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 145 bits (365), Expect = 2e-34
Identities = 153/624 (24%), Positives = 239/624 (38%), Gaps = 70/624 (11%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANI-- 88
+S GE C+ G + +I W+ N R++ V D + L + + +
Sbjct: 75 VSRGEPATLPCRAEGRPRP-NIEWYK--------NGARVATVREDPRAHRLLLPSGALFF 125
Query: 89 ----------DDAGIYKCVVTGEDGSESEATVNVKI-FQKLMFKNAPTPQEFREGEDAVI 137
D G+Y CV G+ + ++++ + F+ +P GE AV+
Sbjct: 126 PRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVL 185
Query: 138 VCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILAR 196
C P P++ W+ G LK++ I + L + K+D G Y C +A
Sbjct: 186 ECVPPRGHPEPSVSWRKDGAR--LKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMA- 242
Query: 197 GEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQ 256
GE +V+V P+ R VN VT +C+ +G P P + W K+ +
Sbjct: 243 GERESAAAEVMVLERPSFLRRP--VNQVVLADAPVTFLCEVKGDPPPRLRWRKE----DG 296
Query: 257 EEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQ 316
E +Y D S L I V DE Y C+AEN G +A+ L V P++
Sbjct: 297 ELPTGRYEIRSDHS-LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQD 355
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNI---SSEEKTLDGHMVVRSHARVSSLTLK 373
E V CE G+P P+I W+ + S+ G V + L +
Sbjct: 356 QMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQ---LNIT 412
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITC 426
++Q DAG Y+C A + G LE++ A LQGP G+ V + C
Sbjct: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
V P ++ W +DGQ L + + T + L + E D G Y+C A + G
Sbjct: 473 RVTGNPQPSVRWKKDGQWLQGDDLQ----FKTMANGTLYIANVQEMDMGFYSCVAKSSTG 528
Query: 487 QESLEFIL-------VQADTPSSPSIDQVEP-------YSSTAQVQFDEPEATGGVPILK 532
+ + L V D P+ PS P + + +P G +
Sbjct: 529 EATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588
Query: 533 YKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
Y E + W + T+ GL+P T Y + A+ GL E S SE
Sbjct: 589 YVIE---AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSE 645
Query: 593 -FKTQPVQGEPSAPKLEGQMGEDG 615
+TQ PS P + G+ G
Sbjct: 646 PVRTQ--DSSPSRPVEDPWRGQQG 667
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/278 (22%), Positives = 103/278 (37%), Gaps = 31/278 (11%)
Query: 306 AKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHA 365
A P+I + E TL C A G P P+I W + +++ + H ++
Sbjct: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121
Query: 366 RV--SSLTLKSIQYTDAGEYICTASNTIG---QDSQSMYLEVQYAPKLQGPVAVYTWEGN 420
+ + D G Y C A N +G + S+ + V Q P V G
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181
Query: 421 QVNITC-EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNC 479
+ C +P ++SW +DG L I I L ++ ++D G Y C
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEE-GRITI----RGGKLMMSHTLKSDAGMYVC 236
Query: 480 TAVNRIGQE---SLEFILVQADTPSSPSIDQV----EPYSSTAQVQFDEP------EATG 526
A N G+ + E ++++ + ++QV P + +V+ D P + G
Sbjct: 237 VASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDG 296
Query: 527 GVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIV 564
+P +Y+ HS W A EG T V
Sbjct: 297 ELPTGRYEIRSD-------HSLWIGHVSAEDEGTYTCV 327
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 143 bits (361), Expect = 6e-34
Identities = 167/700 (23%), Positives = 289/700 (41%), Gaps = 43/700 (6%)
Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
S+ +S E +C V G I+W + L RIS + + + S L I
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPT-ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNIS 472
Query: 85 NANIDDAGIYKCVVTGEDGSES-EATVNVKIFQKLM-FKNAPTPQEFREGEDAVIVCDVV 142
++ + D G+Y+C G +A +NV+ + KN G D I C V+
Sbjct: 473 SSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA----GRDTYIHCRVI 528
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARGEINF 201
+I W +K +++ + +N L++ ++K DEG Y C +L + +++
Sbjct: 529 GYPYYSIKW-YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCN--VLVQPQLST 585
Query: 202 -KDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEP-TMSWTKDGEQIEQEED 259
+ + V V VPP IQ + ++GQ V + C P T++W KDG I
Sbjct: 586 SQSVHVTVKVPPFIQPFEF---PRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLG 642
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
D +S L I + Y CIA N+A + L V PK
Sbjct: 643 -VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDG 701
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEK--TLDGHMVVRSHARVSSLTLKSIQY 377
+ V L C A G P+P+I W+ S + + L+G + V S+ SL +K +
Sbjct: 702 IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG---SLLIKHVVE 758
Query: 378 TDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCEVFAYPSAT 435
D+G Y+C SN +G D S+SMYL V+ + P +G + ++C
Sbjct: 759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPII 818
Query: 436 ISWFRDGQLLP---SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEF 492
+ W ++ +++ + + K S L++ P D G ++C A+N G++
Sbjct: 819 VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878
Query: 493 ILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDA 552
L + P P I+ + + T +++ G PI Y E + + W S
Sbjct: 879 QLTVQEPPDPPEIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKSDS-WDSAQRTK 936
Query: 553 KEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMG 612
+ TI+ + P +TY++R+ A N +G+ ++E + P P E +
Sbjct: 937 DVSPQLNSATIIDIHPSSTYSIRMYAKN--RIGKSEPSNELTITADEAAPDGPPQEVHLE 994
Query: 613 E-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPS-----GSDHVMLKSL 664
SI+V K+ IR Y + YR S+ + + S S+ L +L
Sbjct: 995 PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNL 1054
Query: 665 DWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 702
+ +Y + V A N+ G ++ + T+ + P+ P N
Sbjct: 1055 NKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPEN 1094
Score = 102 bits (255), Expect = 1e-21
Identities = 94/408 (23%), Positives = 159/408 (38%), Gaps = 29/408 (7%)
Query: 87 NIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPT------PQEFREGEDAVIVCD 140
N D Y+C+ E+ + + ++F +AP+ ++ G+ + C
Sbjct: 188 NEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCK 247
Query: 141 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILA 195
+ P W + L + V L I I+ +D G+Y CE G
Sbjct: 248 ALGHPEPDYRWLKDNMPLELSGRFQKTVTG---LLIENIRPSDSGSYVCEVSNRYGTAKV 304
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G + K + TI R+ +++G V+L C G + +SW ++GE +
Sbjct: 305 IGRLYVKQ-----PLKATISPRK----VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC-IAENKAGEQDATIHLKVFAKPKITYVE 314
++ I + L + + K+D Y C + ++K QD + PKI
Sbjct: 356 PGKNVR--ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKS 374
++ + E V+L C G P+P+ITW I M+ VS L + S
Sbjct: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 473
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
Q D G Y CTA+N+ G + V+ ++ + G I C V YP
Sbjct: 474 SQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYY 533
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
+I W+++ LLP N+ + N + +V E D G Y C +
Sbjct: 534 SIKWYKNSNLLP-FNHRQVAFENNGTLKLSDV--QKEVDEGEYTCNVL 578
Score = 87.8 bits (216), Expect = 4e-17
Identities = 94/403 (23%), Positives = 143/403 (35%), Gaps = 21/403 (5%)
Query: 94 YKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKH 153
Y C G V++K + + Q+ G AV C + SS+ I
Sbjct: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Query: 154 KGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDE-GTYRCEGRILARGEINFKDIQVIVNVP 211
+D + L RF++ S L I+ ++ D YRC R GE + +
Sbjct: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219
Query: 212 PTIQARQ---NIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDD 268
P A + A GQ V L C A G PEP W KD +E +K +
Sbjct: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---- 275
Query: 269 SSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLT 328
+ L I+ + +D Y+C N+ G L V K T + + QV+L+
Sbjct: 276 -TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
Query: 329 CEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYIC--T 386
C +G ++W + ++ G V + +L + + +D G Y C
Sbjct: 335 CSVTGTEDQELSWYRNGEILN------PGKNVRITGINHENLIMDHMVKSDGGAYQCFVR 388
Query: 387 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
QD + LE + V++ C V P TI+W D +
Sbjct: 389 KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL 448
Query: 447 SSNYSNIKIYNTPS---ASYLEVTPDSENDFGNYNCTAVNRIG 486
I T SYL ++ D G Y CTA N G
Sbjct: 449 KGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
Score = 79.3 bits (194), Expect = 1e-14
Identities = 152/704 (21%), Positives = 269/704 (38%), Gaps = 81/704 (11%)
Query: 32 SVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA 91
S+G+ F C V I+W +G + P +++ N D +S+L I N ++
Sbjct: 608 SIGQRVFIPCVVVSGDLPITITW-QKDGRPI-PGSLGVTID-NIDFTSSLRISNLSLMHN 664
Query: 92 GIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G Y C+ E + E ++ + V++ K + + P Q+ G+ ++ C PTI+
Sbjct: 665 GNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ--PRDQDGIYGKAVILNCSAEGYPVPTIV 722
Query: 151 WKH-KGRDVILKKDV----RFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
WK KG V + + R VLSN L I+ + + D G Y C+ +++ K +
Sbjct: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVS-KSMY 781
Query: 206 VIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED----DE 261
+ V +P I + N AT GQ + C A G + W K+ I E
Sbjct: 782 LTVKIPAMITSYPNTTLATQ--GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST 839
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMEL 321
K + + S L I + D + C A N GE I L V P +E +
Sbjct: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKAR 899
Query: 322 EEQVTLTCEASGD-PIPS--ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+ T G+ PI I + + + S ++T D +++S T+ I +
Sbjct: 900 TITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKD------VSPQLNSATIIDIHPS 953
Query: 379 DAGEYICTASNTIGQDSQSMYLEV---QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSAT 435
A N IG+ S L + + AP +G + E + S
Sbjct: 954 STYSIRMYAKNRIGKSEPSNELTITADEAAP-----------DGPPQEVHLEPISSQSIR 1002
Query: 436 ISWFRDGQLLPSSNYSNIKI----YNTP-SASYLEVTPDSENDFGNYNCTAVNRIGQESL 490
++W + L + +I Y+T + + ++ D+ D Y +N+ Q L
Sbjct: 1003 VTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGL 1062
Query: 491 EFILVQADTPSSPSIDQVEPYSSTAQ-VQFDEPEATGGVPIL--KYKAEWRAVGEE---- 543
+VQA + E ++T + V PE + W + +E
Sbjct: 1063 ---VVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNG 1119
Query: 544 -------VWHSKWYDAKEASMEGIVT------IVGLKPETTYAVRLAALNGKGLGEISAA 590
++ + D + ++ I T + GL+ T Y++++ A G G S
Sbjct: 1120 ILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQ 1179
Query: 591 SEFKT-QPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLV----RYRALSSE 645
+T + V G P+ K + + V+ + IR Y V Y + SE
Sbjct: 1180 IFTRTKEDVPGPPAGVKAAAA---SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISE 1236
Query: 646 WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFV 689
++ S + +L N +Y V+VVA G+ ++ +
Sbjct: 1237 FEAS----PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276
Score = 79.3 bits (194), Expect = 1e-14
Identities = 95/365 (26%), Positives = 147/365 (40%), Gaps = 34/365 (9%)
Query: 387 ASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWF 439
A + G+ + S + V+ P + P + T+ G + + C+ PS + W
Sbjct: 1263 AVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
Query: 440 RDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADT 499
+D PS + + + S++ T +E D G Y+C A N G + + L
Sbjct: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE-DSGYYSCIANNNWGSDEIILNLQVQVP 1379
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P P + + SS+ + + P GG I Y ++ E W S E S
Sbjct: 1380 PDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR- 1437
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNS-I 618
+ LK T Y L A NG G G IS E KT + EP K + + +
Sbjct: 1438 ---LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKT--LGKEPQFSKEQELFASINTTRV 1492
Query: 619 KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 678
++NLI +DGG PI + + YR + + S S +L L YE+ + N
Sbjct: 1493 RLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN 1552
Query: 679 QQG-KSKAAHFV---FRTSAQPTAIPANGSPTSGLSTG-----------AIVGILIVIFV 723
G K A+F + S P I + GL+T +VG+L+ +FV
Sbjct: 1553 SAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLL-LFV 1611
Query: 724 LLLVV 728
LLLVV
Sbjct: 1612 LLLVV 1616
Score = 70.5 bits (171), Expect = 6e-12
Identities = 86/375 (22%), Positives = 139/375 (37%), Gaps = 68/375 (18%)
Query: 266 SDDSSQLTIKKVDKNDEAEYICIAENKAGEQDA----TIHLKVFAKPKITYVENQTAMEL 321
S DS I + +N + +A AG ++ T+ A +I
Sbjct: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW 1299
Query: 322 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAG 381
+ + L C+A GDP P++ W + S T+DG + S+ S +++++ D+G
Sbjct: 1300 MKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV-TIDGRRSIFSNG---SFIIRTVKAEDSG 1355
Query: 382 EYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRD 441
Y C A+N G D + L+VQ P +Q +T S T+SW
Sbjct: 1356 YYSCIANNNWGSDEIILNLQVQVPP-------------DQPRLTVSKTTSSSITLSW--- 1399
Query: 442 GQLLPSSN-YSNIKIY-------NTPSASYLEVTPDSEN---------DFGNYNCTAVNR 484
LP N S+I+ Y N+ ++P + + + TA N
Sbjct: 1400 ---LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456
Query: 485 IGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKY 533
+G + I ++A T EP S Q F T GG PI +
Sbjct: 1457 VGPGRISEI-IEAKTLGK------EPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSF 1509
Query: 534 KAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEF 593
E+R G VW + A+ S+ + L+ T Y +++ N G E A F
Sbjct: 1510 TLEYRPFGTTVWTT----AQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQA--NF 1563
Query: 594 KTQPVQGEPSAPKLE 608
T G P ++
Sbjct: 1564 ATLNYDGSTIPPLIK 1578
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/108 (29%), Positives = 47/108 (43%), Gaps = 8/108 (7%)
Query: 207 IVNVPPTIQARQNIVNATANLG----QSVTLVCDAEGFPEPTMSWTKD--GEQIEQEEDD 260
I+ V P +A I+ + + + + L C A G P P + W KD G D
Sbjct: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
+ IFS+ S I+ V D Y CIA N G + ++L+V P
Sbjct: 1335 RRSIFSNGS--FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Score = 35.0 bits (79), Expect = 0.29
Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 8/103 (7%)
Query: 133 EDAVIVCDVVSSLPPTIIWKH--KGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+D V+ C V P + W G ++ D R + SN IR +K D G Y C
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC- 1359
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
+A N+ ++I+N+ + Q + + S+TL
Sbjct: 1360 ---IANN--NWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITL 1397
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 142 bits (357), Expect = 2e-33
Identities = 168/656 (25%), Positives = 258/656 (39%), Gaps = 77/656 (11%)
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLS 170
+K F L F + P+ G + ++ C S P I WK G + L D R LS
Sbjct: 34 IKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS 93
Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
N L I+ I K DEG Y+CE + G I + +V V P ++ V TA
Sbjct: 94 NGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESV--TA 151
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
+G +V L C+ G P PT+ W K+ + + D + + S L I ++ D Y
Sbjct: 152 FMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLP-SGALQISRLQPGDIGIY 210
Query: 286 ICIAENKAGEQDAT-IHLKVFAKP----KITYVE---NQTAMELEEQVTLTCEASGDPIP 337
C A N A + +++ + P ++ +++ N A+E ++ V L C SG P P
Sbjct: 211 RCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPP 269
Query: 338 SITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQS 397
S TW I K S S+L + ++ D+G Y C + S S
Sbjct: 270 SFTWLRGEEVIQLRSKKY-------SLLGGSNLLISNVTDDDSGMYTCVVTYKNENISAS 322
Query: 398 MYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456
L V P L P +Y +E + C V P T++W ++G ++ S+Y +
Sbjct: 323 AELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY-----F 377
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQADTPSSPSI-----DQVE 509
S L + ++D G Y C A N G Q S + I+ + PSS + D V
Sbjct: 378 QIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVP 437
Query: 510 PYSSTAQVQFD---EPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGI------ 560
S+ V+ EA G + V+ S+ D +E ++
Sbjct: 438 VLVSSRFVRLSWRPPAEAKGNIQTF-----------TVFFSREGDNRERALNTTQPGSLQ 486
Query: 561 VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKV 620
+T+ LKPE Y R+ A N G GE S + TQP P + + SI +
Sbjct: 487 LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILI 546
Query: 621 NLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQ 680
P++ Y + +S+ + I + S L+ L EY + +A N+
Sbjct: 547 TWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLS--YKLEGLKKFTEYSLRFLAYNRY 604
Query: 681 GKSKAAH--FVFRTSAQPTAIPANGS---------------PTSGLSTGAIVGILI 719
G + V S P+A P N S P SG G I G I
Sbjct: 605 GPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI 660
Score = 103 bits (257), Expect = 7e-22
Identities = 146/622 (23%), Positives = 227/622 (36%), Gaps = 59/622 (9%)
Query: 90 DAGIYKCVVT-GEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPT 148
D G+Y+C + G+ GS T V + L F + G+ ++ C+V+ PT
Sbjct: 111 DEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT 170
Query: 149 IIWKHKGRDVI-LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVI 207
I W+ +D+ + D R +VL + LQI ++ D G YRC R A + +V
Sbjct: 171 IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTG-NEAEVR 229
Query: 208 VNVPPTIQAR----QNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKY 263
+ P + + Q N A G+ L C G+P P+ +W + GE++ Q +
Sbjct: 230 ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEEVIQLRSKKYS 288
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP-KITYVENQTAMELE 322
+ S L I V +D Y C+ K A+ L V P + + N A E
Sbjct: 289 LLG--GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYE-S 345
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYT 378
+ C SG P+P++ W +G +V+ S S+L + + +
Sbjct: 346 MDIEFECTVSGKPVPTVNWMK------------NGDVVIPSDYFQIVGGSNLRILGVVKS 393
Query: 379 DAGEYICTASNTIGQDSQSMYLEV-----------QYAPKLQGPVAVYTWEGNQVNITCE 427
D G Y C A N G S L V AP+ PV V V ++
Sbjct: 394 DEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLV---SSRFVRLSWR 450
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 487
A I F N P + L V + A N G
Sbjct: 451 PPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGP 510
Query: 488 -ESLEFILV----QADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542
ES + I V + P Q S T+ + EP A P+ Y+ V
Sbjct: 511 GESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVST 570
Query: 543 EVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEP 602
+ D +E GLK T Y++R A N G G + + + P
Sbjct: 571 GKEQNIEVDGLSYKLE------GLKKFTEYSLRFLAYNRYGPG--VSTDDITVVTLSDVP 622
Query: 603 SAPKLEGQMG-EDGNSIKVNLIKQDDG--GSPIRHYLVRYRALSSEWKPEIRLPSGSDHV 659
SAP + + SIKV+ + G I Y +R+R + + E P+ +
Sbjct: 623 SAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWY- 681
Query: 660 MLKSLDWNAEYEVYVVAENQQG 681
+ L+ ++Y V A G
Sbjct: 682 LFTGLEKGSQYSFQVSAMTVNG 703
Score = 60.8 bits (146), Expect = 5e-09
Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 26/256 (10%)
Query: 79 STLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIV 138
S L I N DD+G+Y CVVT ++ + S A+ + + F N P+ E D
Sbjct: 293 SNLLISNVTDDDSGMYTCVVTYKNENIS-ASAELTVLVPPWFLNHPSNLYAYESMDIEFE 351
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE 198
C V PT+ W G DV++ D F ++ + L+I G+ K+DEG Y+C +A E
Sbjct: 352 CTVSGKPVPTVNWMKNG-DVVIPSDY-FQIVGGSNLRILGVVKSDEGFYQC----VAENE 405
Query: 199 INFKDIQVIVNVP-PTIQARQNIVNATANL------GQSVTL----VCDAEGFPEP-TMS 246
+ VP P I + + +A ++ + V L +A+G + T+
Sbjct: 406 AGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 465
Query: 247 WTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306
++++G+ E+ + + S QLT+ + + +A N+ G +++ +KV
Sbjct: 466 FSREGDNRERALNTTQ----PGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
Query: 307 KPKITY---VENQTAM 319
+P++ VEN A+
Sbjct: 522 QPELQVPGPVENLQAV 537
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGN-SIKVN 621
I+ L +T Y R+ A N KG+G +S F+T V+ +G+ G+ G + N
Sbjct: 1009 IMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTN 1068
Query: 622 LIKQDDGGSP 631
LI + P
Sbjct: 1069 LIDRSTLNEP 1078
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 141 bits (355), Expect = 3e-33
Identities = 160/629 (25%), Positives = 253/629 (40%), Gaps = 72/629 (11%)
Query: 111 NVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLS 170
+++ F F P G ++ C S P I WK G + L D R +L
Sbjct: 46 SIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLP 105
Query: 171 NNYLQIRGI-----KKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
+ L I + K DEG Y+C + + G I + ++IV P ++ + A
Sbjct: 106 DGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYA 165
Query: 226 NLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEY 285
G + L C+ P + W EQ Q + + S L I + D Y
Sbjct: 166 --GNNAILNCEVNADLVPFVRW----EQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLY 219
Query: 286 ICIAENKA-GEQDATIHLKVFAKPKI----TYVENQTAM--ELEEQVTLTCEASGDPIPS 338
C+ E+ + + LKV P++ +++ + + + + V L C ASG P P+
Sbjct: 220 RCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPT 279
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
I W + + +E +V+ + SL + + DAG Y C A N
Sbjct: 280 IKWMKNEEALDTESSE---RLVLLAG---GSLEISDVTEDDAGTYFCIADNGNETIEAQA 333
Query: 399 YLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQL-LPSSNYSNIKIY 456
L VQ P+ L+ P +Y E + CEV P+ T+ W ++G + +PS + +K +
Sbjct: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEH 393
Query: 457 NTPSASYLEVTPDSENDFGNYNCTAVNRIG--QESLEFILVQ---ADTPSSPSIDQVEPY 511
N L+V ++D G Y C A N +G Q + I+++ A T PS + +
Sbjct: 394 N------LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPR-DVV 446
Query: 512 SSTAQVQFDEPEATGGVPILKYKAEWRAV-----GEEVWHSKWYDAKEASMEGI------ 560
+S +F K WR G+ + +S +Y + + E +
Sbjct: 447 ASLVSTRF-------------IKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHP 493
Query: 561 ----VTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP-VQGEPSAPKLEGQMGEDG 615
VTI L P T Y R+ A N G GE SA +TQP VQ AP L
Sbjct: 494 GEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP- 552
Query: 616 NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVV 675
SI V G I++Y + Y ++ + ++ + S S + L EY VV
Sbjct: 553 TSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS--YTINGLKKYTEYSFRVV 610
Query: 676 AENQQGKSKAAHFV-FRT-SAQPTAIPAN 702
A N+ G + V RT S P+A P N
Sbjct: 611 AYNKHGPGVSTPDVAVRTLSDVPSAAPQN 639
Score = 107 bits (267), Expect = 5e-23
Identities = 157/731 (21%), Positives = 268/731 (36%), Gaps = 103/731 (14%)
Query: 10 TLFFLGTAVSLQVDIV----------PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNG 59
T+ LGT +S ++ P + G + C+V D + W N
Sbjct: 132 TVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF-VRW-EQNR 189
Query: 60 EKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTG------EDGSESEATVNVK 113
+ L + + I + S L I NA D G+Y+CVV D E + + +
Sbjct: 190 QPLLLDDRVIKL-----PSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPE 244
Query: 114 IFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTIIWKHKGRDVILKKDVRFIVLSNN 172
+ L+F P+P G+D V+ C V S LP PTI W + + R ++L+
Sbjct: 245 VISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGG 303
Query: 173 YLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
L+I + + D GTY C +A + Q + V + + N A+ +
Sbjct: 304 SLEISDVTEDDAGTYFC----IADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIV 359
Query: 233 LVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENK 292
C+ G P PT+ W K+G+ + + Y L + + K+DE Y CIAEN
Sbjct: 360 FECEVTGKPTPTVKWVKNGDMVIPSD----YFKIVKEHNLQVLGLVKSDEGFYQCIAEND 415
Query: 293 AGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE 352
G A L + T +A + +TWRT + +
Sbjct: 416 VGNAQAGAQLIILEHAPATTGPLPSAPR-----DVVASLVSTRFIKLTWRTPASDPHGDN 470
Query: 353 KTLD----------GHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
T + SH +T++++ + A N G S L V
Sbjct: 471 LTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530
Query: 403 QYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSAS 462
+ P++Q P G N+ + S T++W + + + N K+Y
Sbjct: 531 ETQPEVQLP-------GPAPNLRAYAASPTSITVTW--ETPVSGNGEIQNYKLY------ 575
Query: 463 YLEVTPDSENDFG----NYNCTAVNRIGQESLEFILVQADTP--SSP--------SIDQV 508
Y+E D E D +Y + + + S + P S+P +
Sbjct: 576 YMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSA 635
Query: 509 EPYSSTAQVQFDE---------PEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P + + +V+ + AT I YK +R S+ D E + G
Sbjct: 636 APQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA------SRKSDVTETLVSG 689
Query: 560 I---VTIVGLKPETTYAVRLAALNGKGLGEIS---AASEFKTQPVQGEPSAPKLEGQMGE 613
I GL T Y R+AAL G G + +A F++ E P++ +
Sbjct: 690 TQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESD--LDETRVPEVPSSLHV 747
Query: 614 DG--NSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYE 671
SI V+ ++ +R Y + Y + S I++ + +++LD ++ Y
Sbjct: 748 RPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQRYYTIENLDPSSHYV 806
Query: 672 VYVVAENQQGK 682
+ + A N G+
Sbjct: 807 ITLKAFNNVGE 817
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 140 bits (352), Expect = 6e-33
Identities = 112/384 (29%), Positives = 163/384 (42%), Gaps = 31/384 (8%)
Query: 26 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYN 85
P +++ G + +F C+ G+ K +I W N E R++++ DD TL I N
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKP-EIIWLRNNNELSMKTDSRLNLL--DDG--TLMIQN 306
Query: 86 ANIDDAGIYKCVVTGEDGSESEATVNVKIF---QKLMFKNAPTPQEFREGEDAVIVCDVV 142
D GIY+C+ G V ++ F + F P E GE + C
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSAT 366
Query: 143 SSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEG--RILARGEIN 200
PP I W +G L D R + + L I+ + + D G Y C I +
Sbjct: 367 GHPPPRISWT-RGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
F +Q + T Q R I GQ+V C+A+G P P ++WTK G Q+ D
Sbjct: 426 FIIVQALPQFTVTPQDRVVIE------GQTVDFQCEAKGNPPPVIAWTKGGSQLSV---D 476
Query: 261 EKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAK--PKITYVENQTA 318
+++ S L I V +D+ +Y C A N G Q HL V + P + + T
Sbjct: 477 RRHLVLS-SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+E+ V L C + G+P P+ITW N + T G + LT+ +
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITW-----NKDGVQVTESGKFHISPEG---FLTINDVGPA 587
Query: 379 DAGEYICTASNTIGQDSQSMYLEV 402
DAG Y C A NTIG S SM L V
Sbjct: 588 DAGRYECVARNTIGSASVSMVLSV 611
Score = 139 bits (350), Expect = 1e-32
Identities = 108/378 (28%), Positives = 161/378 (42%), Gaps = 27/378 (7%)
Query: 124 PTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD 183
P + G C + P IIW ++ +K D R +L + L I+ ++TD
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
Query: 184 EGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIV----NATANLGQSVTLVCDAEG 239
+G Y+C + +A GE+ +++ + P AR V N +G+SVTL C A G
Sbjct: 312 QGIYQCMAKNVA-GEVKTQEVTLRYFGSP---ARPTFVIQPQNTEVLVGESVTLECSATG 367
Query: 240 FPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDAT 299
P P +SWT+ G++ D I S L I+ V + D EY C A N AT
Sbjct: 368 HPPPRISWTR-GDRTPLPVDPRVNI--TPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
Query: 300 IHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359
+ V A P+ T + + V CEA G+P P I W +S + + H+
Sbjct: 425 AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR----HL 480
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ--YAPKLQGPVAVYTW 417
V+ S +L + + D G+Y C A N IG +L VQ P + T
Sbjct: 481 VLSS----GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536
Query: 418 E-GNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
E G V + C P I+W +DG + S K + +P +L + D G
Sbjct: 537 EVGANVQLPCSSQGEPEPAITWNKDGVQVTESG----KFHISPE-GFLTINDVGPADAGR 591
Query: 477 YNCTAVNRIGQESLEFIL 494
Y C A N IG S+ +L
Sbjct: 592 YECVARNTIGSASVSMVL 609
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/198 (28%), Positives = 82/198 (41%), Gaps = 18/198 (9%)
Query: 307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR 366
+P+IT + V TC A G+P P I W + +S + D + +
Sbjct: 245 RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMK---TDSRLNLLDD-- 299
Query: 367 VSSLTLKSIQYTDAGEYICTASNTIGQ-DSQSMYLEVQYAPK----LQGPVAVYTWEGNQ 421
+L +++ Q TD G Y C A N G+ +Q + L +P + P G
Sbjct: 300 -GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES 358
Query: 422 VNITCEVFAYPSATISWFR-DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCT 480
V + C +P ISW R D LP NI TPS L + + D G Y C+
Sbjct: 359 VTLECSATGHPPPRISWTRGDRTPLPVDPRVNI----TPSGG-LYIQNVVQGDSGEYACS 413
Query: 481 AVNRIGQ-ESLEFILVQA 497
A N I + FI+VQA
Sbjct: 414 ATNNIDSVHATAFIIVQA 431
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 139 bits (349), Expect = 1e-32
Identities = 169/708 (23%), Positives = 283/708 (39%), Gaps = 70/708 (9%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ ++WF +G K+ P+ RI++ + TL I + D
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFR-DGRKIPPSS-RIAITLEN----TLVILSTVAPD 177
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNA----------PTPQEFREGEDAVIVCD 140
AG Y + +++ + + + + + A P G V +
Sbjct: 178 AGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC 237
Query: 141 VVSSLPPT---IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARG 197
V ++ P IIWK G V+L + N L I +D G Y CE + +
Sbjct: 238 VANARPLIKLHIIWKKDG--VLLSGGISD---HNRRLTIPNPTGSDAGYYECEAVLRSSS 292
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQE 257
+ + + P ++ + TA + + V + C A+G P P+++W KD +E E
Sbjct: 293 VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE 352
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA-KPKITYVENQ 316
+ +D Q I + +D + C A N AGE + +L V + P IT
Sbjct: 353 KLTRFRQRNDGGLQ--ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLD 410
Query: 317 TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQ 376
+ + V L CE SG P P+ITW+ R ++S L + S SL +
Sbjct: 411 STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES----GSLLISPTH 466
Query: 377 YTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSAT 435
+DAG Y C A+N+ G D S L V ++ P + +G Q ++ C V P T
Sbjct: 467 ISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT 526
Query: 436 IS--WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
I W +DG L + ++ I++ S L ++ D G Y C ++ G +S
Sbjct: 527 IRYIWEKDGATLGTESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT------GGVPILKY-------KAEWRAV 540
L P +P P ++ + V+ T G P+++Y A W +
Sbjct: 584 LRVRQLPHAPE----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVL 639
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600
V D K S VT+ GL P +Y RL A+N G G+ S +E + P +
Sbjct: 640 LASV------DPKATS----VTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP 689
Query: 601 EPSAPKLEGQMGEDGNSIKVNLIKQDDG--GSPIRHYLVRY--RALSSEWKPEIRLPSGS 656
+ P+ G SI + + ++ Y++RY L ++ + +
Sbjct: 690 PTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADV 749
Query: 657 DHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPAN 702
++++L+ L YE+ V A N G + V + Q PT P N
Sbjct: 750 NNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGN 797
Score = 112 bits (279), Expect = 2e-24
Identities = 157/643 (24%), Positives = 248/643 (38%), Gaps = 63/643 (9%)
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PTI 149
AG Y+C+V G+ + V++ F+ Q GE AVI ++S P P +
Sbjct: 86 AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE-INFKDIQVIV 208
W GR + R + N L I D G Y + G+ + I + V
Sbjct: 146 TWFRDGRKI--PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
Query: 209 N--------VPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQEE 258
+ PTI + A + VTL C A P + + W KDG +
Sbjct: 204 ENVGGPADPIAPTIIIPPKNTSVVAGTSE-VTLECVANARPLIKLHIIWKKDGVLLSGG- 261
Query: 259 DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI---HLKVFAKPK-ITYVE 314
SD + +LTI +D Y C A ++ + + +L V P+ + E
Sbjct: 262 ------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315
Query: 315 NQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR-VSSLTLK 373
E+E+ V + C+A G P PSITW + E+ T R R L +
Sbjct: 316 RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT-------RFRQRNDGGLQIS 368
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431
+ D G + C A N G+ S YL V AP + +GP+ +G V + CE
Sbjct: 369 GLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGA 428
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG-QESL 490
P I+W + ++L S + + S S L ++P +D G Y C A N G E+
Sbjct: 429 PRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEAS 487
Query: 491 EFILVQADT-----PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKY--KAEWRAVGEE 543
++V A T P S+ + S V D P T ++Y + + +G E
Sbjct: 488 ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHD-PRVT-----IRYIWEKDGATLGTE 541
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603
H + + S+ T G TY R+ + G S ++ + + + P
Sbjct: 542 S-HPRIRLDRNGSLHISQTWSG--DIGTYTCRVISAGGND----SRSAHLRVRQLPHAPE 594
Query: 604 APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-RLPSGSDHVMLK 662
P + + +I + K DG SP+ Y++ ++ W + + + V +K
Sbjct: 595 HP-VATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK 653
Query: 663 SLDWNAEYEVYVVAENQQGK---SKAAHFVFRTSAQPTAIPAN 702
L Y+ + A N GK SK V PTA P N
Sbjct: 654 GLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQN 696
Score = 67.8 bits (164), Expect = 4e-11
Identities = 142/616 (23%), Positives = 233/616 (37%), Gaps = 100/616 (16%)
Query: 120 FKNAPT-PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLSNNYLQIR 177
FK P Q EG V+ C S P W H R++ + R+++ S
Sbjct: 28 FKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS------- 80
Query: 178 GIKKTDEGTYRC-----EGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVT 232
+ +T G YRC G +L R Q V V + + + + G++
Sbjct: 81 -LDRTHAGFYRCIVRNRMGALLQR--------QTEVQVAYMGSFEEGEKHQSVSHGEAAV 131
Query: 233 LVCD-AEGFPEPTMSWTKDGEQIEQEE------DDEKYIFS---DDSSQLTIKKV-DKND 281
+ FP+P ++W +DG +I ++ I S D+ + ++ V DKN
Sbjct: 132 IRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNG 191
Query: 282 E---AEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
+ ++ I + G I + PK T V T+ +VTL C A+ P+
Sbjct: 192 DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS-----EVTLECVANARPLIK 246
Query: 339 --ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA---SNTIGQ 393
I W+ +S + H R LT+ + +DAG Y C A S+++
Sbjct: 247 LHIIWKKDGVLLSGG---------ISDHNR--RLTIPNPTGSDAGYYECEAVLRSSSVPS 295
Query: 394 DSQSMYLEVQYAPK-LQGPVAVYTWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYS 451
+ YL V P+ ++ P T E + V+I C+ P +I+W++D ++ +
Sbjct: 296 VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT 355
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPY 511
+ N + PD D G + C A N G+ L A T +P+I + P
Sbjct: 356 RFRQRNDGGLQISGLVPD---DTGMFQCFARNAAGEVQTSTYL--AVTSIAPNITR-GPL 409
Query: 512 SSTAQVQFDEPEA--TGGVP---ILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGL 566
ST A T G P I K E V ++ + S+ +++ +
Sbjct: 410 DSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL--LISPTHI 467
Query: 567 KPETTYAVRLAALNGKGLGEISA-----ASEFKTQPVQGEPSAPKLEGQM---GEDGNSI 618
TY A N +G+ E SA A T+P Q + + M +
Sbjct: 468 SDAGTYT--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV 525
Query: 619 KVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLP-SGSDHVMLKSLDWNAEYEVYVVAE 677
+ I + DG + L +E P IRL +GS H+ S W+ + Y
Sbjct: 526 TIRYIWEKDGAT-----------LGTESHPRIRLDRNGSLHI---SQTWSGDIGTYTCRV 571
Query: 678 NQQG--KSKAAHFVFR 691
G S++AH R
Sbjct: 572 ISAGGNDSRSAHLRVR 587
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/161 (26%), Positives = 66/161 (40%), Gaps = 8/161 (4%)
Query: 562 TIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGED--GNSIK 619
T GLKPE+ Y R+ A KG GE + A T+ + P P ED S+
Sbjct: 1361 TATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEK-RDRPQPPSRPMVQQEDVRARSVL 1419
Query: 620 VNLIKQDDGGSPIRHYLVRYRAL-SSEWK-PEIRLPSGSDHVMLKSLDWNAEYEVYVVAE 677
++ DG SP+R+Y ++ R L S W + + ++ L Y+ V A
Sbjct: 1420 LSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT 1479
Query: 678 NQQGK---SKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIV 715
N G S+ + + A P P S T +T ++
Sbjct: 1480 NDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLI 1520
Score = 37.4 bits (85), Expect = 0.059
Identities = 74/345 (21%), Positives = 123/345 (35%), Gaps = 32/345 (9%)
Query: 270 SQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVF-------AKPKITYVENQTAMELE 322
+Q + ++K+ E N GE ++ +VF A P+ V TA +L+
Sbjct: 1582 TQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLD 1641
Query: 323 ---EQVTLTCEASGD--PIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQY 377
E L + +GD W N++ KTL +S+ LK++
Sbjct: 1642 VTWEPPPLDSQ-NGDIQGYKIYFWEAQRGNLTERVKTL--------FLAENSVKLKNLTG 1692
Query: 378 TDAGEYICTASNTIGQDSQSMYLE---VQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSA 434
A A N G +S + Q AP V VN++ E +P+
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
Query: 435 TISWFR--DGQLLPSSNYSNIKIYNTPSAS--YLEVTPDSENDFGNYNCTAVNRIGQESL 490
+ +R P S I + S +L+V +E + A +
Sbjct: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812
Query: 491 EFILVQAD---TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHS 547
E + P P + + YSS + + + G PI +Y E R E +W
Sbjct: 1813 EANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKG-PITRYVIEARPSDEGLWDI 1871
Query: 548 KWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE 592
D + ++ LKP +Y R+ A+N G G S+ S+
Sbjct: 1872 LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQ 1916
Score = 35.8 bits (81), Expect = 0.17
Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 5/129 (3%)
Query: 509 EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKP 568
E ++ +V + EP G+ + Y+ W Y ++E VT GL
Sbjct: 905 EILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY-LPNVTLEYRVT--GLTA 960
Query: 569 ETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDG 628
TTY + +AA+ KG G++SA++ P + P P G S+ + DG
Sbjct: 961 LTTYTIEVAAMTSKGQGQVSASTISSGVPPE-LPGPPTNLGISNIGPRSVTLQFRPGYDG 1019
Query: 629 GSPIRHYLV 637
+ I +LV
Sbjct: 1020 KTSISRWLV 1028
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 139 bits (349), Expect = 1e-32
Identities = 130/491 (26%), Positives = 199/491 (40%), Gaps = 48/491 (9%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
++VGE +C+ +G + I W+ E + + SS L I A D
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVI-WYRGGLEMILAPE--------GSSSGKLRIPAAQERD 642
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
AG Y C E G S A + + + P G A++ C PPT+
Sbjct: 643 AGTYTCRAVNELGDAS-AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVT 701
Query: 151 WKH-KGRDVILK----KDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQ 205
W+ G+ + L+ + R + L + D+ Y CE R + G++ +
Sbjct: 702 WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF-GKVQAEARL 760
Query: 206 VIV-NVPPTIQARQNIVNATANLGQSVTLVCDA-EGFPEPTMSWTKDGEQIEQEEDDEKY 263
++ + PP I + V GQ V+L C G P P W KDG + ++
Sbjct: 761 IVTGHAPPQIASSAPTVRVLE--GQPVSLPCIVLAGRPLPERHWLKDGRPLPP---GSRH 815
Query: 264 IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEE 323
D S L + + + Y C+A N AG Q + L V P+I
Sbjct: 816 SIRADGS-LHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGV 874
Query: 324 QVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
+L C ASG P P+ITW T ++S H V ++ +L + DAG Y
Sbjct: 875 PASLPCVASGVPAPTITWTKETNALTSRGP----HYNV---SKEGTLLIAQPSAQDAGAY 927
Query: 384 ICTASNTIGQDSQSMYLEVQYAPKL--------QGPVAVYTWEGNQVNITCEVFAYPSAT 435
+CTA+NT+G SQ M L V P++ P+ V G +V + CE P
Sbjct: 928 VCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPL 987
Query: 436 ISWFRDGQLLP--SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
++W +D + +P ++ Y + PS S L + D G+Y CTA N G S ++
Sbjct: 988 VTWTKDSRPVPPITNRYGLL-----PSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
Query: 494 L-VQADTPSSP 503
L VQ T P
Sbjct: 1042 LGVQGRTSWQP 1052
Score = 133 bits (335), Expect = 6e-31
Identities = 174/706 (24%), Positives = 277/706 (39%), Gaps = 74/706 (10%)
Query: 31 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDD 90
+S GE+ C+V G+A +++W + L + R++ + + +L I D
Sbjct: 411 VSPGETAVLSCRVLGEAP-YNLTWVR-DWRVLPASTGRVAQL----ADLSLEISGIIPTD 464
Query: 91 AGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G Y+CV + +G + A+V + + + + Q F +G + + C P I
Sbjct: 465 GGRYQCVASNANGV-TRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHIS 523
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINF--KDIQVIV 208
W + + L++D R V + L I+G+ D G Y C+ A E+ + + +
Sbjct: 524 WSRESQ--ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ----ATNEVGTDQETVTLYY 577
Query: 209 NVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDG-EQIEQEEDDEKYIFSD 267
PP++ A +V +G+ LVC+A G P P + W + G E I E
Sbjct: 578 TDPPSVSAVNAVVLVA--VGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-------GS 628
Query: 268 DSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTL 327
S +L I + D Y C A N+ G+ A I L V P++T + +EL L
Sbjct: 629 SSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALL 688
Query: 328 TCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSS-LTLKSIQYTDAGEYICT 386
C A+G P P++TWR L RS S L +S+ D Y+C
Sbjct: 689 ACRATGRPPPTVTWRRGDGQPLG--LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCE 746
Query: 387 ASNTIGQ-DSQSMYLEVQYAPK--LQGPVAVYTWEGNQVNITCEVFA-YPSATISWFRDG 442
A N G+ +++ + +AP V EG V++ C V A P W +DG
Sbjct: 747 ARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806
Query: 443 QLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502
+ LP + +I+ + L + + G Y+C A N G + + LV
Sbjct: 807 RPLPPGSRHSIR-----ADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELV---VQVP 858
Query: 503 PSIDQVEPYSSTAQ-VQFDEPEATGGV--PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P I + T + V P GV P + + E A+ H S EG
Sbjct: 859 PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH------YNVSKEG 912
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP---VQGEPSAP---KLEGQMGE 613
+ I + A A N G T+P + G +A ++ + GE
Sbjct: 913 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGE 972
Query: 614 DGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIR----LPSGSDHVMLKSLDWNAE 669
+ V L + G P LV + S P LPSGS + + +
Sbjct: 973 E-----VTLDCEAKGSPP---PLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGH 1024
Query: 670 YEVYVVAENQQGKSKAAHFV---FRTSAQPTAIPANGSPT--SGLS 710
YE A N G + + + RTS QP ++P P SGLS
Sbjct: 1025 YE--CTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLS 1068
Score = 107 bits (268), Expect = 4e-23
Identities = 90/366 (24%), Positives = 147/366 (40%), Gaps = 25/366 (6%)
Query: 136 VIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILA 195
++ C V S+LP + + + + L ++ F N+ +I K +EGTY C +
Sbjct: 328 LVSCSVHSALPFRL--QLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTA-VSR 384
Query: 196 RGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIE 255
G K V+ + PP + N+ T + G++ L C G ++W +D +
Sbjct: 385 AGTGRAKAQIVVTDPPPQLVPAPNV---TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP 441
Query: 256 QEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVEN 315
+ L I + D Y C+A N G A++ L V P+++ +
Sbjct: 442 ASTGRVAQL---ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTS 498
Query: 316 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSI 375
+V ++C ASG P P I+W S E + L + A+ +L ++ +
Sbjct: 499 SQHFSQGVEVKVSCSASGYPTPHISW-------SRESQALQEDSRIHVDAQ-GTLIIQGV 550
Query: 376 QYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVA-VYTWEGNQVNITCEVFAYPSA 434
DAG Y C A+N +G D +++ L P + A V G + + CE P
Sbjct: 551 APEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP 610
Query: 435 TISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL 494
+ W+R G I S+ L + E D G Y C AVN +G S E L
Sbjct: 611 RVIWYRGG-------LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
Query: 495 VQADTP 500
P
Sbjct: 664 AVGHAP 669
Score = 89.0 bits (219), Expect = 2e-17
Identities = 68/259 (26%), Positives = 110/259 (42%), Gaps = 31/259 (11%)
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
+E++ +S I + K +E Y C A ++AG A + V P +
Sbjct: 352 EERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTV 411
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVS-----SLTLKS 374
E L+C G+ ++TW D ++ S RV+ SL +
Sbjct: 412 SPGETAVLSCRVLGEAPYNLTW------------VRDWRVLPASTGRVAQLADLSLEISG 459
Query: 375 IQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT-----WEGNQVNITCEVF 429
I TD G Y C ASN G S++L V+ AP+ V+++T +G +V ++C
Sbjct: 460 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQ----VSIHTSSQHFSQGVEVKVSCSAS 515
Query: 430 AYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQES 489
YP+ ISW R+ Q L + ++ T L + + D GNY+C A N +G +
Sbjct: 516 GYPTPHISWSRESQALQEDSRIHVDAQGT-----LIIQGVAPEDAGNYSCQATNEVGTDQ 570
Query: 490 LEFILVQADTPSSPSIDQV 508
L D PS +++ V
Sbjct: 571 ETVTLYYTDPPSVSAVNAV 589
Score = 43.5 bits (101), Expect = 8e-04
Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 12/231 (5%)
Query: 368 SSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWE-GNQVNITC 426
SS + + G Y CTA + G + V P P T G ++C
Sbjct: 362 SSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSC 421
Query: 427 EVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIG 486
V ++W RD ++LP+S ++ + LE++ D G Y C A N G
Sbjct: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS----LEISGIIPTDGGRYQCVASNANG 477
Query: 487 QESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWH 546
L+ + P + +S +V+ + P + + E +A+ E+
Sbjct: 478 VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED--- 534
Query: 547 SKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP 597
+G + I G+ PE A N G + + + P
Sbjct: 535 ----SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPP 581
>gi|142976733 surface glycoprotein, Ig superfamily member [Homo
sapiens]
Length = 1264
Score = 137 bits (346), Expect = 3e-32
Identities = 168/711 (23%), Positives = 276/711 (38%), Gaps = 117/711 (16%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGS--ESEAT 109
ISW NG+ L N + + + TLTI + N G Y+C+ G+ AT
Sbjct: 59 ISWLH-NGKTLDGNLEHVKI-----HQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPAT 112
Query: 110 VNVKIFQKL--MFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVR-F 166
V+V + K+ T +E G I C V S P + ++K R L+ +
Sbjct: 113 VSVAVLGDFGSSTKHVITAEEKSAG---FIGCRVPESNPKAEV-RYKIRGKWLEHSTENY 168
Query: 167 IVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDI--QVIVNVPPTIQAR---QNIV 221
++L + LQI + D+G+Y+C ++ + I +++V+ P +
Sbjct: 169 LILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHS 228
Query: 222 NATANLGQS-VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKN 280
A A L +S VTL C G P P + W KDG+ I + + S L VD
Sbjct: 229 QALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLY-----SHLATDSVDPA 283
Query: 281 DEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339
D Y C+A NK+G+ + T + V I+ + L V TC+ G+P P+
Sbjct: 284 DSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNC 343
Query: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMY 399
TW + + I + H+ + ++S +T++ D G Y C A N IG +
Sbjct: 344 TWFHNAQPIHPSAR----HLTAGNGLKISGVTVE-----DVGMYQCVADNGIGFMHSTGR 394
Query: 400 LEVQ----YAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPS------- 447
LE++ + P + PV+ +G+ V ++C P I W+ L+ S
Sbjct: 395 LEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLR 454
Query: 448 --SNYSNIK------------IYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFI 493
S S + + + AS L + ++ G Y C A N G E
Sbjct: 455 SKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGTTQAEAS 514
Query: 494 LVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAK 553
L+ V P+ + KAE + + + +
Sbjct: 515 LM------------VVPFETNT------------------KAETVTLPDAAQNDD-RSKR 543
Query: 554 EASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE 613
+ S G+++ +K + N G+ + A + P P L + G+
Sbjct: 544 DGSETGLLSSFPVKVHPSAVESAPEKNASGI-SVPDAPIILSPPQTHTPDTYNLVWRAGK 602
Query: 614 DGNSIKVNLIKQDDGGSPIRHYLVRYRALS------SEWKPEIRLPSGSDHVMLKSLDWN 667
DGG PI Y V+YR L W +R+P + + L L+ +
Sbjct: 603 -------------DGGLPINAYFVKYRKLDDGVGMLGSWH-TVRVPGSENELHLAELEPS 648
Query: 668 AEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN---GSPTSGLSTGAIV 715
+ YEV +VA + G+ + A FRTS + TA N SP G+ +V
Sbjct: 649 SLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSKNTQASSPPVGIPKYPVV 699
Score = 53.1 bits (126), Expect = 1e-06
Identities = 61/277 (22%), Positives = 110/277 (39%), Gaps = 43/277 (15%)
Query: 500 PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
P +P + S T+ P A GG PI +K E++ + W D + +
Sbjct: 721 PEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLS- 779
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLGEISAAS----------EFKTQPVQGEPSAPKLEG 609
V + L+P +TY R+ A+N G S+AS F ++P+ G P E
Sbjct: 780 -VEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITG-PHIAYTEA 837
Query: 610 QMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL----SSEWKPEIRLPSGSDHVMLKSLD 665
+ + +K I + +PI+ + + YR S++K ++ S H M+ L
Sbjct: 838 -VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWH-MIGHLQ 895
Query: 666 WNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTG------------- 712
Y++ + N+ G+S+ ++ + + A+ P LST
Sbjct: 896 PETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPA 955
Query: 713 -----------AIVGILIVIFVLLLVVVDITCYFLNK 738
IVG ++ + VL+L+V C + N+
Sbjct: 956 TSPARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNR 992
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 137 bits (344), Expect = 5e-32
Identities = 167/686 (24%), Positives = 267/686 (38%), Gaps = 68/686 (9%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
++WF G K+ P+ RI++ + L I DAG Y E E++ +
Sbjct: 223 VTWFR-EGHKIIPSN-RIAITLENQ----LVILATTTSDAGAYYVQAVNEKNGENKTSPF 276
Query: 112 VKIFQKLMFKNAPTPQEFRE------GEDAVIV------CDVVSSLPP----TIIWKHKG 155
+ + + ++ TP+ G +V+ + ++S P ++ WK G
Sbjct: 277 IHLS---IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG 333
Query: 156 RDVI--LKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPT 213
+ L R + +SN D G Y CE + + + + P
Sbjct: 334 VRITSGLHSFGRRLTISNP-------TSADTGPYVCEAALPGSAFEPARATAFLFIIEPP 386
Query: 214 IQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLT 273
+ +A + ++V + C A G P PT+ W KD I + ++ + + S L
Sbjct: 387 YFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLA--SGGLR 444
Query: 274 IKKVDKNDEAEYICIAENKAGEQDATIHLKVF-AKPKITYVENQTAMELEEQVTLTCEAS 332
I+K+ D + C A N+ GE +L V P T T + L CE S
Sbjct: 445 IQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVS 504
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P+ITW+ ++S + M++ S L + + DAG Y C A+NT G
Sbjct: 505 GAPKPAITWKRENHILASGSVRIPRFMLLES----GGLQIAPVFIQDAGNYTCYAANTEG 560
Query: 393 QDSQSMYLEVQYAPKLQGPVAVYTW-EGNQVNITCEVFAYPSATIS--WFRDGQLLPSSN 449
+ S L V + P + +G + C P ++ W +D L S+
Sbjct: 561 SLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS 620
Query: 450 YSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE 509
S I + S L ++ D G+Y+C V+ G +S L + P SP V
Sbjct: 621 TSRIVVEKDGS---LLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
Query: 510 PYSSTAQV-------QFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562
P SS + FD G PIL Y E + W + M G VT
Sbjct: 678 PNSSHSHAVVLSWVRPFD-----GNSPILYYIVEL-SENNSPWKVHLSNVGP-EMTG-VT 729
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNL 622
+ GL P TY R+ A+N G G+ SA + P + + PK G SI V
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
Query: 623 --IKQDDGGSPIRHYLVRYR--ALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAEN 678
+ + +R Y++RYR L E++ ++ ++ L +YE+ V A N
Sbjct: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYN 849
Query: 679 QQGKSKAAHFVFRTSAQ--PTAIPAN 702
G + V + Q PTA P N
Sbjct: 850 GAGLGVFSRAVTEYTLQGVPTAPPQN 875
Score = 111 bits (278), Expect = 2e-24
Identities = 150/656 (22%), Positives = 255/656 (38%), Gaps = 62/656 (9%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLP-PT 148
DAG Y+CVV G+ + V++ F + + +G A++ ++S P P
Sbjct: 163 DAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQ 222
Query: 149 IIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN-------- 200
+ W +G +I R + N L I +D G Y + GE
Sbjct: 223 VTWFREGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
Query: 201 -FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWTKDGEQIEQE 257
+D+ + PTI + A ++ TL C A P + +++W ++G +I
Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSET-TLECIASARPVEDLSVTWKRNGVRITSG 339
Query: 258 EDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQD---ATIHLKVFAKPKIT-YV 313
+LTI D Y+C A + AT L + P T
Sbjct: 340 -------LHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEP 392
Query: 314 ENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLK 373
E++ + E+EE V + C+A G P+P++ W +IS + + V+ S L ++
Sbjct: 393 ESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQN--PRYKVLAS----GGLRIQ 446
Query: 374 SIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKL-QGPVAVYTWEGNQVNITCEVFAY 431
++ D+G + C ASN G+ YL+V AP Q PV +G + CEV
Sbjct: 447 KLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGA 506
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
P I+W R+ +L S + I + + L++ P D GNY C A N G +
Sbjct: 507 PKPAITWKRENHILASGSV-RIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNAS 565
Query: 492 FILVQADTPS--SPSIDQVEPYSSTAQVQ---FDEPEATGGVPILKYKAEWRAVGEEVWH 546
L + S P D V +TA + +P + L+Y VW
Sbjct: 566 ATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVS-----LRY----------VWK 610
Query: 547 SKWYDAKEASMEGIVTIV--GLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSA 604
+S IV L T++ + + + + E S V P +
Sbjct: 611 KDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHS 670
Query: 605 PK--LEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEI-RLPSGSDHVML 661
P+ L +++ ++ ++ DG SPI +Y+V +S WK + + V +
Sbjct: 671 PQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTV 730
Query: 662 KSLDWNAEYEVYVVAENQQGKSKAAHFVFR--TSAQPTAIPANGSPTSGLSTGAIV 715
L Y+ V A N+ G+ + + R +P + P SG + +I+
Sbjct: 731 SGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIM 786
Score = 43.5 bits (101), Expect = 8e-04
Identities = 48/202 (23%), Positives = 83/202 (41%), Gaps = 11/202 (5%)
Query: 513 STAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTY 572
++ ++ + PE G+ IL Y+ +R + + T L PE+ Y
Sbjct: 1392 TSVRIVWQPPEEPNGI-ILGYQIAYRLASSSPHTFTTVEVGATVRQ--FTATDLAPESAY 1448
Query: 573 AVRLAALNGKGLGEISAASEFKTQPVQGEPSAPK--LEGQMGEDGNSIKVNLIKQDDGGS 630
RL+A +G GE A+ T+ + P+ P+ L Q S+++ + DG S
Sbjct: 1449 IFRLSAKTRQGWGEPLEATVITTEKRE-RPAPPRELLVPQAEVTARSLRLQWVPGSDGAS 1507
Query: 631 PIRHYLVRYRAL-SSEWKP-EIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHF 688
PIR++ ++ R L EW+ + + ++ L Y++ + A N G S F
Sbjct: 1508 PIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDS---DF 1564
Query: 689 VFRTSAQPTAIPANGSPTSGLS 710
T A T G P +S
Sbjct: 1565 SSETEAVTTLQDVPGEPPGSVS 1586
Score = 40.8 bits (94), Expect = 0.005
Identities = 58/281 (20%), Positives = 103/281 (36%), Gaps = 62/281 (22%)
Query: 228 GQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYIC 287
G + L C AEG W +D ++ + KYI I + K D Y C
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKYI---------IPSLQKLDAGFYRC 169
Query: 288 IAENKAGEQDATIHLKVFAKPKITYV-------ENQTAMELEEQVTLTCEASGDPIPSIT 340
+ N+ G A + K ++ ++ Y+ + +T + + + P P +T
Sbjct: 170 VVRNRMG---ALLQRK--SEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVT 224
Query: 341 WRTSTRNISSEEKTLDGHMVVRSH----ARVSSLTLKSIQYTDAGEYICTASN-TIGQDS 395
W +GH ++ S+ + L + + +DAG Y A N G++
Sbjct: 225 W------------FREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENK 272
Query: 396 QSMYLEVQYA-----PKLQGPVAVYTWEGN--------QVNITCEVFAYP--SATISWFR 440
S ++ + A P+ P V GN + + C A P +++W R
Sbjct: 273 TSPFIHLSIARDVGTPETMAPTIVVP-PGNRSVVAGSSETTLECIASARPVEDLSVTWKR 331
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
+G + S +S L ++ + D G Y C A
Sbjct: 332 NGVRITSGLHS--------FGRRLTISNPTSADTGPYVCEA 364
Score = 33.5 bits (75), Expect = 0.85
Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 1/93 (1%)
Query: 499 TPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASME 558
+P SP V +S +Q+ E + G P Y E R E +W D ++
Sbjct: 1902 SPGSPRDVLVTKSASELTLQWTEGHS-GDTPTTGYVIEARPSDEGLWDMFVKDIPRSATS 1960
Query: 559 GIVTIVGLKPETTYAVRLAALNGKGLGEISAAS 591
+++ L+ TY R+ A+N G GE S S
Sbjct: 1961 YTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 130 bits (326), Expect = 7e-30
Identities = 130/506 (25%), Positives = 203/506 (40%), Gaps = 36/506 (7%)
Query: 122 NAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK 181
NA +E R G + C + LP II+ K D +L K+ LQI + +
Sbjct: 270 NASNKEELR-GNVLSLEC-IAEGLPTPIIYWAK-EDGMLPKNRTVYKNFEKTLQIIHVSE 326
Query: 182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241
D G Y+C + A G I+ + P I A QN+V + G+ TL+C A G P
Sbjct: 327 ADSGNYQCIAK-NALGAIHHTISVRVKAAPYWITAPQNLV---LSPGEDGTLICRANGNP 382
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
+P +SW +G IE DD D+ + V + A Y C A N+ G A
Sbjct: 383 KPRISWLTNGVPIEIAPDDPSRKIDGDT--IIFSNVQERSSAVYQCNASNEYGYLLANAF 440
Query: 302 LKVFAKPKITYVENQTAMEL--EEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHM 359
+ V A+P T ++ L C G P+P+I W + + E H
Sbjct: 441 VNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH- 499
Query: 360 VVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWE 418
+L + Q G Y C A N +G ++LE++ + + P
Sbjct: 500 ------ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553
Query: 419 GNQVNITCEV--FAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGN 476
G+ V+ C+V S T+ W +D + LPS T +L V S++D G
Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERF------TVDKDHLVVADVSDDDSGT 607
Query: 477 YNCTAVNRIGQESLEFILVQADTPSSP-SIDQVEPYSSTAQVQFDEPEATGGVPILKYKA 535
Y C A + S +L D P+ P ++ + + Q+ + P PI K+
Sbjct: 608 YTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSW-TPGDDNNSPITKFII 666
Query: 536 EWRAVGEEVWHSK--WYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASE- 592
E+ E+ H W+ E S + L P Y+ R+ A+N G S ASE
Sbjct: 667 EY----EDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQ 722
Query: 593 FKTQPVQGEPSAPKLEGQMGEDGNSI 618
+ T+ + + + +EG E N +
Sbjct: 723 YLTKASEPDKNPTAVEGLGSEPDNLV 748
Score = 107 bits (266), Expect = 6e-23
Identities = 153/671 (22%), Positives = 243/671 (36%), Gaps = 89/671 (13%)
Query: 92 GIYKCVVTGEDGSESEATVNVKIFQK-LMFKNAPTPQEFREGEDAVIVCDVVSSLPPTII 150
G+Y+C E G+ + V+ + L K P + G+ V+ C LPP II
Sbjct: 113 GVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPII 172
Query: 151 WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTD-EGTYRCEGR------ILARGEINFKD 203
+ L + R N L + D Y C R I + I+ K
Sbjct: 173 FWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232
Query: 204 IQV-------IVNV--------------PPTIQARQ-NIVNATANLGQSVTLVCDAEGFP 241
I V N+ PPT + N N G ++L C AEG P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292
Query: 242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIH 301
P + W K+ + + + ++ + L I V + D Y CIA+N G TI
Sbjct: 293 TPIIYWAKEDGMLPKN----RTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTIS 348
Query: 302 LKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNI----SSEEKTLDG 357
++V A P + E TL C A+G+P P I+W T+ I + +DG
Sbjct: 349 VRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDG 408
Query: 358 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV-QYAPKLQGPV-AVY 415
++ S ++Q + Y C ASN G + ++ V P++ P +Y
Sbjct: 409 DTIIFS----------NVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLY 458
Query: 416 TWEGNQ-VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
N+ + C F P TI WF+ + + + IY LE+ ++
Sbjct: 459 QVIANRPALLDCAFFGSPLPTIEWFKGAK----GSALHEDIYVLHENGTLEIPVAQKDST 514
Query: 475 GNYNCTAVNRIGQESLEFILVQAD------TPSSPSIDQVEPYSSTAQVQFDEPEATGGV 528
G Y C A N++G E L D P + + S +V+ D
Sbjct: 515 GTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDH------- 567
Query: 529 PILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
L W E+ + + + + +V V TY + L +S
Sbjct: 568 -TLSLTVLWLKDNRELPSDERFTVDKDHL--VVADVSDDDSGTY----TCVANTTLDSVS 620
Query: 589 AASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--- 645
A++ V P +L Q+ + S++++ DD SPI +++ Y +
Sbjct: 621 ASAVLSVVDVPNPPFDLELTDQLDK---SVQLSWTPGDDNNSPITKFIIEYEDAMHKPGL 677
Query: 646 WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKS--KAAHFVFRTSA-----QPTA 698
W + + SG+ L Y V+A N GKS A + T A PTA
Sbjct: 678 WHHQTEV-SGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTA 736
Query: 699 IPANGSPTSGL 709
+ GS L
Sbjct: 737 VEGLGSEPDNL 747
Score = 97.4 bits (241), Expect = 5e-20
Identities = 145/675 (21%), Positives = 244/675 (36%), Gaps = 108/675 (16%)
Query: 80 TLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVC 139
TL I + + D+G Y+C+ G+ T++V++ + AP GED ++C
Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALGAIHH-TISVRVKAAPYWITAPQNLVLSPGEDGTLIC 376
Query: 140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE-----GRIL 194
+ P I W G + + D + + + +++ Y+C G +L
Sbjct: 377 RANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLL 436
Query: 195 ARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQI 254
A +N V+ P + + AN + L C G P PT+ W K +
Sbjct: 437 ANAFVN-----VLAEPPRILTPANTLYQVIAN--RPALLDCAFFGSPLPTIEWFKGAKGS 489
Query: 255 EQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVE 314
ED Y+ ++ + L I K+ Y C+A NK G +HL++ I
Sbjct: 490 ALHEDI--YVLHENGT-LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQP 546
Query: 315 NQTAMELEEQVTLTCEASGDPIPSIT--WRTSTRNISSEEKTLDGHMVVRSHARVSSLTL 372
++ V+ C+ D S+T W R + S+E+ V + H L +
Sbjct: 547 EYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDER----FTVDKDH-----LVV 597
Query: 373 KSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYTWEGNQV 422
+ D+G Y C A+ T+ S S L V P +L V + G+
Sbjct: 598 ADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDN 657
Query: 423 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 482
N F I + D P + ++ T + + L+++P F AV
Sbjct: 658 NSPITKF------IIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSF---RVMAV 708
Query: 483 NRIGQ----ESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGV----PILKYK 534
N IG+ E+ E L +A P + VE S + G P L+YK
Sbjct: 709 NSIGKSLPSEASEQYLTKASEPDK-NPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYK 767
Query: 535 AEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFK 594
WR ++ +W A++ + + G Y +++ ALN G
Sbjct: 768 VSWR---QKDGDDEWTSVVVANVSKYI-VSGTPTFVPYLIKVQALNDMGFA--------- 814
Query: 595 TQPVQGEPSAPKLEGQMGED-----GNSIKVNLIKQDDGG--------SPIRHYLVRYRA 641
P + G GED +++VN++ IR +L YR
Sbjct: 815 -------PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRI 867
Query: 642 LSSEWKPE--------------IRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA- 686
WK + + H ML L+ + Y + V N +G+ A+
Sbjct: 868 Y--YWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASP 925
Query: 687 HFVFRTSAQPTAIPA 701
VF T P +P+
Sbjct: 926 DRVFNT---PEGVPS 937
Score = 62.4 bits (150), Expect = 2e-09
Identities = 92/410 (22%), Positives = 147/410 (35%), Gaps = 59/410 (14%)
Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNN-----YLQIRGIKKTDEGTY 187
E+ VI C+ PP+ W G + KD + + G +T EG Y
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 115
Query: 188 RCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAE-GFPEPTMS 246
+C R RG +I V + P + ++ + T GQS+ L C G P P +
Sbjct: 116 QCTAR-NERGAAVSNNIVVRPSRSP-LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIF 173
Query: 247 WTKDG-EQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE-YICIA---ENKAGEQDATIH 301
W + +++ Q E + + D L V D E YIC A + +Q I
Sbjct: 174 WMDNSFQRLPQSERVSQGLNGD----LYFSNVLPEDTREDYICYARFNHTQTIQQKQPIS 229
Query: 302 LKVFA-------------------------KPKITYVENQTAMELEE----QVTLTCEAS 332
+KV + +P A EE ++L C A
Sbjct: 230 VKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE 289
Query: 333 GDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIG 392
G P P I W + E+ L + V + +L + + D+G Y C A N +G
Sbjct: 290 GLPTPIIYW-------AKEDGMLPKNRTVYKNFE-KTLQIIHVSEADSGNYQCIAKNALG 341
Query: 393 QDSQSMYLEVQYAPK-LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYS 451
++ + V+ AP + P + G + C P ISW +G + +
Sbjct: 342 AIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD 401
Query: 452 NIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTP 500
+ + + + V E Y C A N G + F+ V A+ P
Sbjct: 402 PSRKIDGDTIIFSNV---QERSSAVYQCNASNEYGYLLANAFVNVLAEPP 448
Score = 52.8 bits (125), Expect = 1e-06
Identities = 74/324 (22%), Positives = 124/324 (38%), Gaps = 69/324 (21%)
Query: 211 PPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSS 270
PPTI +Q+ + + +++ + C+A+G P P+ SWT++G + ++ D +
Sbjct: 39 PPTI-TQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDK-DPLVTMKPGTG 96
Query: 271 QLTIKKVDKND----EAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAME-----L 321
L I + + E Y C A N+ G A + + +P + + + +E
Sbjct: 97 TLIINIMSEGKAETYEGVYQCTARNERG---AAVSNNIVVRPSRSPLWTKEKLEPITLQS 153
Query: 322 EEQVTLTCEAS-GDPIPSITWR-TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
+ + L C G P P I W S + + E+ S L ++ D
Sbjct: 154 GQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERV--------SQGLNGDLYFSNVLPED 205
Query: 380 AGE-YICTA----SNTIGQDSQSMYLEVQYAPKLQGPVAV-------------------- 414
E YIC A + TI Q Q + ++V +L +A
Sbjct: 206 TREDYICYARFNHTQTI-QQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF 264
Query: 415 YTWEGNQVN----------ITCEVFAYPSATISWFRDGQLLPSSN--YSNIKIYNTPSAS 462
T EGN N + C P+ I W ++ +LP + Y N +
Sbjct: 265 LTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFE-------K 317
Query: 463 YLEVTPDSENDFGNYNCTAVNRIG 486
L++ SE D GNY C A N +G
Sbjct: 318 TLQIIHVSEADSGNYQCIAKNALG 341
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 130 bits (326), Expect = 7e-30
Identities = 163/722 (22%), Positives = 287/722 (39%), Gaps = 60/722 (8%)
Query: 27 SQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSS--STLTIY 84
S+ ++ GE +C G A ++W + + R + D + S + +
Sbjct: 475 SEKVVNPGEQFSLMCAAKG-APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVT 533
Query: 85 NANIDDAGIYKCVVTGEDGS-ESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIV 138
I D G+Y+C GS E +A +NV+ P+ + R G D +I
Sbjct: 534 GPQIRDGGVYRCTARNLVGSAEYQARINVR--------GPPSIRAMRNITAVAGRDTLIN 585
Query: 139 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKK-TDEGTYRCEGRILARG 197
C V+ +I W ++L + R +V N L++ ++K DEG Y C I +
Sbjct: 586 CRVIGYPYYSIKWYKDA--LLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
Query: 198 EINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPT-MSWTKDGEQIEQ 256
I+ + + V V VPP IQ + A++GQ + + C P ++W KDG+ I
Sbjct: 644 SIS-QSVHVAVKVPPLIQPFEF---PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699
Query: 257 EE----DDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITY 312
+ ++++ S L I V Y CIA N A L V P+
Sbjct: 700 GSGVTIESKEFM-----SSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVV 754
Query: 313 VENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEE---KTLDGHMVVRSHARVSS 369
N + L C G P P + W+ + + + ++ L G + + + SS
Sbjct: 755 QPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPN---SS 811
Query: 370 LTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYAPKLQG-PVAVYTWEGNQVNITCE 427
L ++ + D G Y+C ASN +G D S+SM+L V+ + P +G+ + C
Sbjct: 812 LLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCT 871
Query: 428 VFAYPSATISWFRDGQLLPSSNYSNIKIYNTPS----ASYLEVTPDSENDFGNYNCTAVN 483
I W + ++ I + S L++ P D ++C A+N
Sbjct: 872 ARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAIN 931
Query: 484 RIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEE 543
G++ L + P P ++ E + + +++ + G I + E++ +
Sbjct: 932 SYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDS 990
Query: 544 VWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPS 603
W K + IV L P + Y++R+ + N G E S T+ + P
Sbjct: 991 -WDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTE--EAAPD 1047
Query: 604 APKLEGQMGE-DGNSIKV--NLIKQDDGGSPIRHYLVRYRALSSEWK-----PEIRLPSG 655
P ++ + SI+V K++ IR Y + YR S E++
Sbjct: 1048 GPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGD 1107
Query: 656 SDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQ--PTAIPANGSPTSGLSTGA 713
S+ L +L A+Y V V A N+ G ++ + T+ + P+ P N S S A
Sbjct: 1108 SEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVA 1167
Query: 714 IV 715
++
Sbjct: 1168 VI 1169
Score = 108 bits (270), Expect = 2e-23
Identities = 121/509 (23%), Positives = 197/509 (38%), Gaps = 54/509 (10%)
Query: 66 QQRISVV-WNDDSSSTLT-----------IYNANI---DDAGIYKCVVTGEDGSESEATV 110
Q+ +SVV W D+ S + +Y +++ D Y+C+ + E+ +
Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272
Query: 111 NVKIFQKLMFKNAPT------PQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDV 164
++ ++ PT QE G + C P I W GR L D
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--LPADS 330
Query: 165 RFIVLSNNYLQIRGIKKTDEGTYRCE-----GRILARGEINFKDIQVIVNVPPTIQARQN 219
R+ L I ++ D GTY CE G A G + D + P ++
Sbjct: 331 RWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT--- 386
Query: 220 IVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279
+G +V L C G PE T+ W ++ E + +E S+++ L I K
Sbjct: 387 ------GIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET--LLITSAQK 438
Query: 280 NDEAEYICIAENKAGE-QDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPS 338
+ Y C A KA QD I P+I ++ + EQ +L C A G P P+
Sbjct: 439 SHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPT 498
Query: 339 ITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398
+TW I + + +S + + Q D G Y CTA N +G
Sbjct: 499 VTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
Query: 399 YLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNT 458
+ V+ P ++ + G I C V YP +I W++D LLP N+ + N
Sbjct: 559 RINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLP-DNHRQVVFEN- 616
Query: 459 PSASYLEVTPDSEN-DFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVE-PYSSTAQ 516
L++T + D G Y C+ + + + + V P P I E P +S Q
Sbjct: 617 ---GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVP--PLIQPFEFPPASIGQ 671
Query: 517 VQFDE-PEATGGVPILKYKAEWRAVGEEV 544
+ + ++G +PI + WR G+ +
Sbjct: 672 LLYIPCVVSSGDMPI---RITWRKDGQVI 697
Score = 80.9 bits (198), Expect = 5e-15
Identities = 154/673 (22%), Positives = 254/673 (37%), Gaps = 80/673 (11%)
Query: 90 DAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFRE-----GEDAVIVCDVVSS 144
D G Y C V + +V+V + K P Q F G+ I C V S
Sbjct: 629 DEGEYLCSVLIQPQLSISQSVHVAV------KVPPLIQPFEFPPASIGQLLYIPCVVSSG 682
Query: 145 -LPPTIIWKHKGRDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILARGEIN 200
+P I W+ G+ +I V + S + LQI + G Y C A
Sbjct: 683 DMPIRITWRKDGQVIISGSGVT--IESKEFMSSLQISSVSLKHNGNYTCIASNAAATVS- 739
Query: 201 FKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDD 260
++ Q+IV VPP + N N G++ L C +G+P P + W + + +
Sbjct: 740 -RERQLIVRVPPRFVVQPN--NQDGIYGKAGVLNCSVDGYPPPKVMW----KHAKGSGNP 792
Query: 261 EKY--------IFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQ-DATIHLKVFAKPKIT 311
++Y I +S L I+ V + D Y+C A N G ++ L V IT
Sbjct: 793 QQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMIT 852
Query: 312 YVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHAR--VSS 369
N T L C A G+ I W + ++ + + + + VS+
Sbjct: 853 SHPNTTIAIKGHAKELNCTARGERPIIIRWEKGD-TVIDPDRVMRYAIATKDNGDEVVST 911
Query: 370 LTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP----------KLQGPVAVYT--W 417
L LK D+ + C A N+ G+D + L VQ P K + +T +
Sbjct: 912 LKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971
Query: 418 EGNQVNITCEVFAYPSATISW-FRDG--QLLPSSNYSNIKIYNTPSASYLEVTPDSENDF 474
+GN + IT Y + + SW F+ + P+ N +NI +++ P S
Sbjct: 972 DGNSI-ITGFDIEYKNKSDSWDFKQSTRNISPTINQANI----------VDLHPASVYSI 1020
Query: 475 GNYNCTAVNRIGQESLEFILVQADTPSSPSID-QVEPYSSTA-QVQFDEP--EATGGVPI 530
Y+ + R I + P P +D ++P +S + QV + P E GV I
Sbjct: 1021 RMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGV-I 1079
Query: 531 LKYKAEWR--AVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEIS 588
Y+ +R + G +S + K + T+ LK Y V + A N G G S
Sbjct: 1080 RGYQIGYRENSPGSNGQYSI-VEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSS 1138
Query: 589 AASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRAL------ 642
SE ++ PS P + + + V + + S + L YR +
Sbjct: 1139 --SEINATTLEDVPSQPPENVRALSITSDVAV-ISWSEPPRSTLNGVLKGYRVIFWSLYV 1195
Query: 643 SSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702
EW + + + V L+ ++ Y V V+A Q G + ++ + + P
Sbjct: 1196 DGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPA 1255
Query: 703 GSPTSGLSTGAIV 715
G S ++V
Sbjct: 1256 GIKAVPSSASSVV 1268
Score = 71.2 bits (173), Expect = 4e-12
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 55/319 (17%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGE 382
+ V L C + GDP P++ W + + S+ ++DGH ++ ++ +L L++++ D+G
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSED-SAIPVSMDGHRLIHTNG---TLLLRAVKAEDSGY 1420
Query: 383 YICTASNTIGQDSQSMYLEVQYAP--------KLQGPVAVYTW---EGNQVNITCEVFAY 431
Y CTA+NT G D+ + L VQ P K TW + +I V Y
Sbjct: 1421 YTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQY 1480
Query: 432 PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLE 491
++D + SS+ + K+ + ++ +V ++N G+ RI +
Sbjct: 1481 SVDNSEEWKD--VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGS------GRISE---- 1528
Query: 492 FILVQADTPSSPSIDQVEPYSSTAQVQFDEPEAT-----------GGVPILKYKAEWRAV 540
+++A T EP S Q F +T GG PI E+R
Sbjct: 1529 --IIEAKTHGR------EPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPK 1580
Query: 541 GEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQG 600
G W A+ G V + L+ T Y +R+ A N G G +A +F T G
Sbjct: 1581 GTWAW-----QGLRANSSGEVFLTELREATWYELRMRACNSAGCGNETA--QFATLDYDG 1633
Query: 601 EPSAPKLEGQMGEDGNSIK 619
+ P ++ GE G+ +K
Sbjct: 1634 S-TIPPIKSAQGE-GDDVK 1650
Score = 63.9 bits (154), Expect = 6e-10
Identities = 86/354 (24%), Positives = 137/354 (38%), Gaps = 31/354 (8%)
Query: 392 GQDSQSMYLEVQYAPKLQGPVAVYTWEGN-------QVNITCEVFAYPSATISWFRDGQ- 443
G S+ + +E P + P + ++ G V + C P+ + W +D +
Sbjct: 1334 GNSSEKVTIE----PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSED 1389
Query: 444 -LLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSS 502
+P S + I+ + V + D G Y CTA N G +++ L+ P
Sbjct: 1390 SAIPVSMDGHRLIHTNGTLLLRAVKAE---DSGYYTCTATNTGGFDTIIVNLLVQVPPDQ 1446
Query: 503 PSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVT 562
P + + +S+ + + P GG I + ++ E W + + E S +
Sbjct: 1447 PRLTVSKTSASSITLTWI-PGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFK---- 1501
Query: 563 IVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGE-DGNSIKVN 621
+ LK T Y V+LAA N G G IS E KT EPS K + + ++N
Sbjct: 1502 LDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTH--GREPSFSKDQHLFTHINSTHARLN 1559
Query: 622 LIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQG 681
L ++GG PI ++ YR W + + S V L L YE+ + A N G
Sbjct: 1560 LQGWNNGGCPITAIVLEYRP-KGTWAWQGLRANSSGEVFLTELREATWYELRMRACNSAG 1618
Query: 682 -KSKAAHFVFRTSAQPTAIP-----ANGSPTSGLSTGAIVGILIVIFVLLLVVV 729
++ A F T P G L T IL + V LL +V
Sbjct: 1619 CGNETAQFATLDYDGSTIPPIKSAQGEGDDVKKLFTIGCPVILATLGVALLFIV 1672
Score = 56.2 bits (134), Expect = 1e-07
Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 33/298 (11%)
Query: 219 NIVNATANLGQSVTLVCDAEGFPEPTMSW-TKDGEQIEQEEDDEKYIFSDDSSQLTIKKV 277
++ T + V + C A G P + W G+ I + +++ ++ + QL
Sbjct: 91 SLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDI-YDVPHIRHVHANGTLQLYPFSP 149
Query: 278 DKND----EAEYICIAENKAGE-QDATIHLK-VFAKPKITYVENQTAMELEEQV--TLTC 329
+ + +Y C AEN AG+ + I +K VF +P VE+Q +M V L
Sbjct: 150 SAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIP 209
Query: 330 EASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDA-GEYIC-TA 387
+ + + ++W T +I E + + H L + +Q DA Y C T
Sbjct: 210 SSVQEYVSVVSWEKDTVSIIPEHR-----FFITYH---GGLYISDVQKEDALSTYRCITK 261
Query: 388 SNTIGQDSQSMYLEVQYAPK-------LQGPVAVYTWEGNQVNITCEVFAYPSATISWFR 440
G+ QS + L G + W G+ V + C YP I W +
Sbjct: 262 HKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLK 321
Query: 441 DGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 498
DG+ LP+ + +I + L ++ D G Y C N G IL+ D
Sbjct: 322 DGRPLPADSRWTKRI------TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVID 373
Score = 44.3 bits (103), Expect = 5e-04
Identities = 70/328 (21%), Positives = 123/328 (37%), Gaps = 50/328 (15%)
Query: 208 VNVPPTIQARQNIVN----ATANLGQSVTLVCDAEGFPEPTMSWTKDGEQ--IEQEEDDE 261
V + P +A I++ T + V L C++ G P P + WTKD E I D
Sbjct: 1340 VTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGH 1399
Query: 262 KYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA---KPKITYVENQTA 318
+ I ++ + L ++ V D Y C A N G ++L V +P++T + +
Sbjct: 1400 RLIHTNGT--LLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSAS 1457
Query: 319 MELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYT 378
+TLT + SI ++ + E+ D + + S R S L S++
Sbjct: 1458 -----SITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKD--VFISSSER--SFKLDSLKCG 1508
Query: 379 DAGEYICTASNTIGQDSQSMYLEVQ---YAPKLQGPVAVYT-------------WEGNQV 422
+ A N++G S +E + P ++T W
Sbjct: 1509 TWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGC 1568
Query: 423 NITCEVFAY-PSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
IT V Y P T +W Q L +++ + + A++ E+ + N G
Sbjct: 1569 PITAIVLEYRPKGTWAW----QGLRANSSGEVFLTELREATWYELRMRACNSAG------ 1618
Query: 482 VNRIGQESLEFILVQADTPSSPSIDQVE 509
G E+ +F + D + P I +
Sbjct: 1619 ---CGNETAQFATLDYDGSTIPPIKSAQ 1643
Score = 34.3 bits (77), Expect = 0.50
Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 8/103 (7%)
Query: 133 EDAVIVCDVVSSLPPTIIWKHKGRD--VILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+D + C+ V P + W D + + D ++ +N L +R +K D G Y C
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTL 233
G + + ++V VPP Q R + +A+ S+TL
Sbjct: 1425 A--TNTGGFDTIIVNLLVQVPPD-QPRLTVSKTSAS---SITL 1461
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 127 bits (319), Expect = 4e-29
Identities = 161/696 (23%), Positives = 269/696 (38%), Gaps = 94/696 (13%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I W P+G V + + TL + +D G Y+C+ GS A
Sbjct: 269 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 321
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170
V + + + P + GE A + C V P + W+ G V L KD ++ +
Sbjct: 322 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 380
Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
L + ++ +D +CE R +LA I +V +P I N
Sbjct: 381 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 434
Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
G + L+C A G P P++ W +DG + Q+E F + L I+ + ND
Sbjct: 435 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 489
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342
Y C+A N +LKV +IT T + +VT TC+AS DP PSITWR
Sbjct: 490 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
R++ E D + + L + S+ Y+D G Y C AS + L V
Sbjct: 550 GDGRDL-QELGDSDKYFI-----EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 603
Query: 403 QYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDGQLLPSSNYSN 452
+P GPV ++ +QV ++ +A I F D ++ P YS
Sbjct: 604 VGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSL 660
Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS 512
K+ +++ L+++P F TA+N+ G + TP + P
Sbjct: 661 GKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP------EAAPEK 711
Query: 513 STAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
+ V+ + E T V P ++Y+ +WR G W + + +
Sbjct: 712 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPWQE--QIVSDP 766
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPKLEG--QMGED 614
+ + Y +++ A+N +G G +++ + P + P+LEG +
Sbjct: 767 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPELEGIEILNSS 822
Query: 615 GNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGSDHVMLKSLDW 666
+K + +R Y V Y S+ K + +P+ + V+L L
Sbjct: 823 AVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRP 882
Query: 667 NAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702
+ Y + V A N +G A+ F F T P +P +
Sbjct: 883 YSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 915
Score = 108 bits (271), Expect = 2e-23
Identities = 127/542 (23%), Positives = 203/542 (37%), Gaps = 76/542 (14%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96
C+ +G + W + +G P ++ V+ S + TI N + A GIY+C
Sbjct: 52 CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 109
Query: 97 VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149
+ + G+ + +LM + AP P E EGE V+ C+ S P
Sbjct: 110 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 163
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205
I+ + + +K+D R + N L + +D + Y C I K D++
Sbjct: 164 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 223
Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
V I P + + + A GQ + L C AEGFP PT+ W + +
Sbjct: 224 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 280
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
++ + + + L + KV + D+ EY C+AEN G ++ V A P +
Sbjct: 281 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 339
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E L C+ G P P +TWR + I EE D ++ A L L ++Q +D
Sbjct: 340 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELAKDQKYRIQRGA----LILSNVQPSD 393
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITCEVFAYPSATI 436
C A N G + Y+ V P L Y +G+ + C+ F P ++
Sbjct: 394 TMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSV 453
Query: 437 SW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
W +D + P +N L + ND G Y C A N
Sbjct: 454 QWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYFCLAANDQNNV 501
Query: 489 SLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542
++ L D P S + + T Q FD P L+ WR G
Sbjct: 502 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQPSITWRGDGR 553
Query: 543 EV 544
++
Sbjct: 554 DL 555
Score = 84.7 bits (208), Expect = 3e-16
Identities = 119/511 (23%), Positives = 202/511 (39%), Gaps = 52/511 (10%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+G A ++C + P++ W + +L+ D RF +N L IR ++ D G Y C
Sbjct: 435 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 492
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248
LA + N I + V Q Q + G VT C A P +P+++W
Sbjct: 493 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 549
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
DG +++ D +KY D +L I +D +D+ Y C+A + ++ L V P
Sbjct: 550 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607
Query: 309 KIT--YVENQTAMELEEQVTLTCEASGD---PIPSITWRTSTRNISSEEKTLDGHMVVRS 363
V + + + QV ++ + D PI + ++ E+ + + +
Sbjct: 608 GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK----WYSLGKV 663
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGN 420
+S TLK Y + TA N G S E P+ + PV V EGN
Sbjct: 664 PGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV-KGEGN 721
Query: 421 QVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
+ IT + + + W G P +I + P +L V+ S
Sbjct: 722 ETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLVVSNTS 774
Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDEPEATG 526
AVN G+ + + D P + P ++ +E +S+A + P
Sbjct: 775 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 834
Query: 527 GVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAVRLAAL 579
V + Y + G + HSK + K+ A+ ++ + GL+P ++Y + + A
Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHLEVQAF 893
Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610
NG+G G S + + V G P A LE Q
Sbjct: 894 NGRGSGPASEFTFSTPEGVPGHPEALHLECQ 924
Score = 60.1 bits (144), Expect = 9e-09
Identities = 95/385 (24%), Positives = 142/385 (36%), Gaps = 56/385 (14%)
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285
++L C+A G PE WT+DG + +E+ ++ S S TI + N + Y
Sbjct: 48 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 107
Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340
C A NK G I L PK E +E+E E V L C S +P+
Sbjct: 108 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 166
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA----SNTIGQDS- 395
+ +I +E+ G A V L S ++D YIC A + TI Q
Sbjct: 167 MNSKILHIKQDERVTMGQNGNLYFANV----LTSDNHSD---YICHAHFPGTRTIIQKEP 219
Query: 396 -----QSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
++ + P+L P + +G + + C +P+ TI W R +P
Sbjct: 220 IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMP 279
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA-----DTP 500
+ + T L++ E D G Y C A N +G ++ V+A P
Sbjct: 280 ADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKP 334
Query: 501 SSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
S E QVQ +PE T WR G V D K G
Sbjct: 335 QSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKYRIQRG 382
Query: 560 IVTIVGLKPETTYAVRLAALNGKGL 584
+ + ++P T + A N GL
Sbjct: 383 ALILSNVQPSDTMVTQCEARNRHGL 407
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%)
Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468
Q P + + + +++ CE P W RDG + +Y +P + +T
Sbjct: 35 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 94
Query: 469 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 510
++ N G Y C A N++G S E L+ P P + V+P
Sbjct: 95 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 140
Score = 32.0 bits (71), Expect = 2.5
Identities = 46/195 (23%), Positives = 74/195 (37%), Gaps = 28/195 (14%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS-HARVSSLTLKSIQYTD-- 379
+ ++L CEASG P W + +E+ G V +S H+ ++T + +
Sbjct: 46 DDISLKCEASGKPEVQFRWTRDGVHFKPKEEL--GVTVYQSPHSGSFTITGNNSNFAQRF 103
Query: 380 AGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATI 436
G Y C ASN +G S + L + APK V EG V + C
Sbjct: 104 QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCN--------- 154
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILV 495
P + ++IY ++ L + D G N N N + ++ +
Sbjct: 155 ---------PPPSAEPLRIY-WMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 204
Query: 496 QADTPSSPSIDQVEP 510
A P + +I Q EP
Sbjct: 205 HAHFPGTRTIIQKEP 219
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 127 bits (319), Expect = 4e-29
Identities = 161/696 (23%), Positives = 269/696 (38%), Gaps = 94/696 (13%)
Query: 52 ISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVN 111
I W P+G V + + TL + +D G Y+C+ GS A
Sbjct: 274 IKWLRPSGPMPADR------VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY- 326
Query: 112 VKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVI-LKKDVRFIVLS 170
V + + + P + GE A + C V P + W+ G V L KD ++ +
Sbjct: 327 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRI-Q 385
Query: 171 NNYLQIRGIKKTDEGTYRCEGR-----ILARGEINFKDIQVIVNVPPTIQARQNIVNATA 225
L + ++ +D +CE R +LA I +V +P I N
Sbjct: 386 RGALILSNVQPSDTMVTQCEARNRHGLLLANAYI------YVVQLPAKILTADNQTYMAV 439
Query: 226 NLGQSVTLVCDAEGFPEPTMSWT-KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAE 284
G + L+C A G P P++ W +DG + Q+E F + L I+ + ND
Sbjct: 440 Q-GSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDER----FFPYANGTLGIRDLQANDTGR 494
Query: 285 YICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPI--PSITWR 342
Y C+A N +LKV +IT T + +VT TC+AS DP PSITWR
Sbjct: 495 YFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554
Query: 343 TSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEV 402
R++ E D + + L + S+ Y+D G Y C AS + L V
Sbjct: 555 GDGRDL-QELGDSDKYFI-----EDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV 608
Query: 403 QYAPKLQGPVA------VYTWEGNQVNITCEVFAYPSATIS----WFRDGQLLPSSNYSN 452
+P GPV ++ +QV ++ +A I F D ++ P YS
Sbjct: 609 VGSP---GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSL 665
Query: 453 IKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYS 512
K+ +++ L+++P F TA+N+ G + TP + P
Sbjct: 666 GKVPGNQTSTTLKLSPYVHYTF---RVTAINKYGPGEPSPVSETVVTP------EAAPEK 716
Query: 513 STAQVQFDEPEATGGV-------------PILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
+ V+ + E T V P ++Y+ +WR G W + + +
Sbjct: 717 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGT---RGPWQE--QIVSDP 771
Query: 560 IVTIVGLKPETTYAVRLAALNGKGLG---EISAASEFKTQPVQGEPSAPKLEG--QMGED 614
+ + Y +++ A+N +G G +++ + P + P+LEG +
Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP----QAIPELEGIEILNSS 827
Query: 615 GNSIKVNLIKQDDGGSPIRHYLVRYRALSSE--------WKPEIRLPSGSDHVMLKSLDW 666
+K + +R Y V Y S+ K + +P+ + V+L L
Sbjct: 828 AVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRP 887
Query: 667 NAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPAN 702
+ Y + V A N +G A+ F F T P +P +
Sbjct: 888 YSSYHLEVQAFNGRGSGPASEFTFST---PEGVPGH 920
Score = 108 bits (271), Expect = 2e-23
Identities = 127/542 (23%), Positives = 203/542 (37%), Gaps = 76/542 (14%)
Query: 41 CQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDA----GIYKC 96
C+ +G + W + +G P ++ V+ S + TI N + A GIY+C
Sbjct: 57 CEASGKP-EVQFRW-TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRC 114
Query: 97 VVTGEDGSESEATVNVKIFQKLMFKNAPT-------PQEFREGEDAVIVCDVVSSLPPTI 149
+ + G+ + +LM + AP P E EGE V+ C+ S P
Sbjct: 115 FASNKLGTAMSHEI------RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLR 168
Query: 150 IWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGT-YRCEGRILARGEINFK---DIQ 205
I+ + + +K+D R + N L + +D + Y C I K D++
Sbjct: 169 IYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLR 228
Query: 206 V------IVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEED 259
V I P + + + A GQ + L C AEGFP PT+ W + +
Sbjct: 229 VKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPA--- 285
Query: 260 DEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAM 319
++ + + + L + KV + D+ EY C+AEN G ++ V A P +
Sbjct: 286 -DRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLY 344
Query: 320 ELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTD 379
E L C+ G P P +TWR + I EE D ++ A L L ++Q +D
Sbjct: 345 GPGETARLDCQVQGRPQPEVTWRIN--GIPVEELAKDQKYRIQRGA----LILSNVQPSD 398
Query: 380 AGEYICTASNTIGQDSQSMYLEVQYAPK--LQGPVAVY-TWEGNQVNITCEVFAYPSATI 436
C A N G + Y+ V P L Y +G+ + C+ F P ++
Sbjct: 399 TMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSV 458
Query: 437 SW--------FRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQE 488
W +D + P +N L + ND G Y C A N
Sbjct: 459 QWLDEDGTTVLQDERFFPYAN------------GTLGIRDLQANDTGRYFCLAANDQNNV 506
Query: 489 SLEFILVQADT------PSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 542
++ L D P S + + T Q FD P L+ WR G
Sbjct: 507 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFD--------PSLQPSITWRGDGR 558
Query: 543 EV 544
++
Sbjct: 559 DL 560
Score = 84.7 bits (208), Expect = 3e-16
Identities = 119/511 (23%), Positives = 202/511 (39%), Gaps = 52/511 (10%)
Query: 131 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
+G A ++C + P++ W + +L+ D RF +N L IR ++ D G Y C
Sbjct: 440 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQ-DERFFPYANGTLGIRDLQANDTGRYFC- 497
Query: 191 GRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP--EPTMSWT 248
LA + N I + V Q Q + G VT C A P +P+++W
Sbjct: 498 ---LAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWR 554
Query: 249 KDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKP 308
DG +++ D +KY D +L I +D +D+ Y C+A + ++ L V P
Sbjct: 555 GDGRDLQELGDSDKYFIED--GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612
Query: 309 KIT--YVENQTAMELEEQVTLTCEASGD---PIPSITWRTSTRNISSEEKTLDGHMVVRS 363
V + + + QV ++ + D PI + ++ E+ + + +
Sbjct: 613 GPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEK----WYSLGKV 668
Query: 364 HARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL---QGPVAVYTWEGN 420
+S TLK Y + TA N G S E P+ + PV V EGN
Sbjct: 669 PGNQTSTTLKLSPYVHY-TFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDV-KGEGN 726
Query: 421 QVN---ITCEVFAYPSAT-------ISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDS 470
+ IT + + + W G P +I + P +L V+ S
Sbjct: 727 ETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQE----QIVSDP---FLVVSNTS 779
Query: 471 ENDFGNYNCTAVNRIGQESLEFILVQ---ADTPSS-PSIDQVEPYSSTAQVQFDEPEATG 526
AVN G+ + + D P + P ++ +E +S+A + P
Sbjct: 780 TFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLA 839
Query: 527 GVP--ILKYKAEWRAVGEEVWHSKWYDAKE-----ASMEGIVTIVGLKPETTYAVRLAAL 579
V + Y + G + HSK + K+ A+ ++ + GL+P ++Y + + A
Sbjct: 840 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVI-LSGLRPYSSYHLEVQAF 898
Query: 580 NGKGLGEISAASEFKTQPVQGEPSAPKLEGQ 610
NG+G G S + + V G P A LE Q
Sbjct: 899 NGRGSGPASEFTFSTPEGVPGHPEALHLECQ 929
Score = 60.1 bits (144), Expect = 9e-09
Identities = 95/385 (24%), Positives = 142/385 (36%), Gaps = 56/385 (14%)
Query: 231 VTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIF-SDDSSQLTIKKVDKN----DEAEY 285
++L C+A G PE WT+DG + +E+ ++ S S TI + N + Y
Sbjct: 53 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIY 112
Query: 286 ICIAENKAG-EQDATIHLKVFAKPKITYVENQTAMELE--EQVTLTCE--ASGDPIPSIT 340
C A NK G I L PK E +E+E E V L C S +P+
Sbjct: 113 RCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEEGESVVLPCNPPPSAEPLRIYW 171
Query: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA----SNTIGQDS- 395
+ +I +E+ G A V L S ++D YIC A + TI Q
Sbjct: 172 MNSKILHIKQDERVTMGQNGNLYFANV----LTSDNHSD---YICHAHFPGTRTIIQKEP 224
Query: 396 -----QSMYLEVQYAPKLQGPV----AVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 446
++ + P+L P + +G + + C +P+ TI W R +P
Sbjct: 225 IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMP 284
Query: 447 SSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQA-----DTP 500
+ + T L++ E D G Y C A N +G ++ V+A P
Sbjct: 285 ADRVTYQNHNKT-----LQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKP 339
Query: 501 SSPSIDQVEPYSSTAQVQ-FDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEG 559
S E QVQ +PE T WR G V D K G
Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVT-----------WRINGIPV-EELAKDQKYRIQRG 387
Query: 560 IVTIVGLKPETTYAVRLAALNGKGL 584
+ + ++P T + A N GL
Sbjct: 388 ALILSNVQPSDTMVTQCEARNRHGL 412
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/107 (24%), Positives = 44/107 (41%), Gaps = 6/107 (5%)
Query: 409 QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTP 468
Q P + + + +++ CE P W RDG + +Y +P + +T
Sbjct: 40 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99
Query: 469 DSENDF----GNYNCTAVNRIGQE-SLEFILVQADTPSSPSIDQVEP 510
++ N G Y C A N++G S E L+ P P + V+P
Sbjct: 100 NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPK-ETVKP 145
Score = 32.0 bits (71), Expect = 2.5
Identities = 46/195 (23%), Positives = 74/195 (37%), Gaps = 28/195 (14%)
Query: 323 EQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS-HARVSSLTLKSIQYTD-- 379
+ ++L CEASG P W + +E+ G V +S H+ ++T + +
Sbjct: 51 DDISLKCEASGKPEVQFRWTRDGVHFKPKEEL--GVTVYQSPHSGSFTITGNNSNFAQRF 108
Query: 380 AGEYICTASNTIGQD-SQSMYLEVQYAPKLQGPVA--VYTWEGNQVNITCEVFAYPSATI 436
G Y C ASN +G S + L + APK V EG V + C
Sbjct: 109 QGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCN--------- 159
Query: 437 SWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFG-NYNCTAVNRIGQESLEFILV 495
P + ++IY ++ L + D G N N N + ++ +
Sbjct: 160 ---------PPPSAEPLRIY-WMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 496 QADTPSSPSIDQVEP 510
A P + +I Q EP
Sbjct: 210 HAHFPGTRTIIQKEP 224
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,222,499
Number of Sequences: 37866
Number of extensions: 1634272
Number of successful extensions: 13290
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 282
Number of HSP's successfully gapped in prelim test: 295
Number of HSP's that attempted gapping in prelim test: 4901
Number of HSP's gapped (non-prelim): 3581
length of query: 848
length of database: 18,247,518
effective HSP length: 111
effective length of query: 737
effective length of database: 14,044,392
effective search space: 10350716904
effective search space used: 10350716904
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.