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Search of human proteins with 94400919
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94400919 WD repeat domain 90 [Homo sapiens]
(1748 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94400919 WD repeat domain 90 [Homo sapiens] 3563 0.0
gi|223005862 echinoderm microtubule associated protein like 6 [H... 179 3e-44
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 150 8e-36
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H... 112 4e-24
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 93 3e-18
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H... 77 2e-13
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 75 4e-13
gi|56790932 echinoderm microtubule associated protein like 1 iso... 74 2e-12
gi|56790930 echinoderm microtubule associated protein like 1 iso... 74 2e-12
gi|223029510 echinoderm microtubule associated protein like 4 is... 73 2e-12
gi|19923497 echinoderm microtubule associated protein like 4 iso... 72 4e-12
gi|19913369 transducin beta-like 3 [Homo sapiens] 69 3e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 69 4e-11
gi|113865883 WD repeat domain 38 [Homo sapiens] 69 5e-11
gi|110227615 echinoderm microtubule associated protein like 3 [H... 64 1e-09
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 62 5e-09
gi|157266266 WD repeat domain 86 [Homo sapiens] 62 5e-09
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 62 5e-09
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 62 5e-09
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 62 6e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 62 6e-09
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 62 6e-09
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 62 6e-09
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 62 6e-09
gi|31377846 WD repeat domain 52 [Homo sapiens] 62 6e-09
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 61 1e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 60 1e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 60 1e-08
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 60 1e-08
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 60 1e-08
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 3563 bits (9239), Expect = 0.0
Identities = 1748/1748 (100%), Positives = 1748/1748 (100%)
Query: 1 MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKS 60
MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKS
Sbjct: 1 MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKS 60
Query: 61 STQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPL 120
STQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPL
Sbjct: 61 STQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPL 120
Query: 121 VLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCYGHLKSIRLCASLLVRNLYTS 180
VLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCYGHLKSIRLCASLLVRNLYTS
Sbjct: 121 VLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCYGHLKSIRLCASLLVRNLYTS 180
Query: 181 DLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDRYIHVRFPSESLKVPSKPIEKSC 240
DLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDRYIHVRFPSESLKVPSKPIEKSC
Sbjct: 181 DLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDRYIHVRFPSESLKVPSKPIEKSC 240
Query: 241 SPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTASGRAALAPRPFPEVSLSQER 300
SPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTASGRAALAPRPFPEVSLSQER
Sbjct: 241 SPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTASGRAALAPRPFPEVSLSQER 300
Query: 301 SDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLR 360
SDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLR
Sbjct: 301 SDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLR 360
Query: 361 LKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGS 420
LKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGS
Sbjct: 361 LKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGS 420
Query: 421 SSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTM 480
SSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTM
Sbjct: 421 SSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTM 480
Query: 481 VVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRS 540
VVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRS
Sbjct: 481 VVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRS 540
Query: 541 CPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLP 600
CPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLP
Sbjct: 541 CPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLP 600
Query: 601 TRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGP 660
TRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGP
Sbjct: 601 TRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGP 660
Query: 661 VSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQ 720
VSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQ
Sbjct: 661 VSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQ 720
Query: 721 DRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEH 780
DRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEH
Sbjct: 721 DRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEH 780
Query: 781 TCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALA 840
TCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALA
Sbjct: 781 TCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALA 840
Query: 841 VSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHL 900
VSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHL
Sbjct: 841 VSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHL 900
Query: 901 LVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQA 960
LVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQA
Sbjct: 901 LVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQA 960
Query: 961 SPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPG 1020
SPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPG
Sbjct: 961 SPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPG 1020
Query: 1021 AGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASC 1080
AGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASC
Sbjct: 1021 AGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASC 1080
Query: 1081 KAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRL 1140
KAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRL
Sbjct: 1081 KAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRL 1140
Query: 1141 VVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQH 1200
VVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQH
Sbjct: 1141 VVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQH 1200
Query: 1201 LIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPW 1260
LIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPW
Sbjct: 1201 LIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPW 1260
Query: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS
Sbjct: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
Query: 1321 GQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG 1380
GQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG
Sbjct: 1321 GQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG 1380
Query: 1381 ASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNE 1440
ASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNE
Sbjct: 1381 ASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNE 1440
Query: 1441 VVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAA 1500
VVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAA
Sbjct: 1441 VVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAA 1500
Query: 1501 GYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTF 1560
GYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTF
Sbjct: 1501 GYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTF 1560
Query: 1561 RVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS 1620
RVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS
Sbjct: 1561 RVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS 1620
Query: 1621 FPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEKIPLPFFAM 1680
FPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEKIPLPFFAM
Sbjct: 1621 FPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEKIPLPFFAM 1680
Query: 1681 SLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFTPSARLLFTAARNEI 1740
SLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFTPSARLLFTAARNEI
Sbjct: 1681 SLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFTPSARLLFTAARNEI 1740
Query: 1741 LVWEVPGL 1748
LVWEVPGL
Sbjct: 1741 LVWEVPGL 1748
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 179 bits (453), Expect = 3e-44
Identities = 302/1239 (24%), Positives = 480/1239 (38%), Gaps = 176/1239 (14%)
Query: 359 LRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALD 418
LRL+ V G+ GH R L+ G VVY V VV Q+FFLGH D + +LAL
Sbjct: 11 LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIISLALH 70
Query: 419 GSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-MHVVCSLSFSDSGALLCGVGKDHHG 477
+L+A+ Q + +WD + + L + H V L+F G L VG D
Sbjct: 71 PDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQRLASVGLDAKN 130
Query: 478 RTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTF--FDETRMASCGQGSVRLWRLRG 535
+ W G++ + A H+D + F +++ + R+ SCG ++ W L G
Sbjct: 131 TVCIWDWRKGKL------LASATGHSD---RIFDISWDPYQPNRVVSCGVKHIKFWTLCG 181
Query: 536 GVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHA 595
L + G+ LQ T L A++ A +G I +V
Sbjct: 182 NALTAKRGIFGKTGDLQ-TILCLACAKEDITYSGAL-------NGDIYVWKGLNLV---- 229
Query: 596 RRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSV---- 651
RT G H S+G I S+ A G DG +RLW DF +
Sbjct: 230 ------RTIQGAH------SAG----IFSMYACEEGFATGGRDGCIRLWDTDFKPITKID 273
Query: 652 LLEAE--HEG-PVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAM 708
L E E ++G + SVC D R+L+ T S ++ ++ R P+L L
Sbjct: 274 LRETEQGYKGLSIRSVCWKAD--RLLAGTQD---------SEIFEVIVRERDKPMLIL-Q 321
Query: 709 EQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRS 768
G+L W LA HP +P G +VR
Sbjct: 322 GHCEGEL-----------WALA-------------------LHPKKPLAVTGSDDRSVRL 351
Query: 769 FSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMV 828
+SL A L+ AV + +PDG L GS D V V
Sbjct: 352 WSL-ADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
Query: 829 CPDAPASP--SALAV-SRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLD 885
+ SP S LAV S DG + + R S SL + +D D
Sbjct: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTND 470
Query: 886 SAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIR--ELPGVHPEPCPSLTL-SEDARF 942
A F G L TS + + S ++ E+ G+ P+ + S DA +
Sbjct: 471 GAGERLFYRMPSGKPL--TSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANY 528
Query: 943 ---LLIAAGR--TIKVWDY-ATQASPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDA---V 993
+L++ +K++ + + + Y+GHS V V +S D Q VLS G A V
Sbjct: 529 NSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSV 588
Query: 994 FLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPR--QQVPKPCQASPPRLG 1051
F W + S+ AP + G E++ S S++P + + Q + R
Sbjct: 589 FQWRFIPEGVSNGMLETAP---QEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQV 645
Query: 1052 VCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPASGGWLRLK 1111
P+ +++ +N P +L KA P S L+L+
Sbjct: 646 YKEDLPQLKQQSKE-KNHAVP---FLKREKA------------------PEDS---LKLQ 680
Query: 1112 AVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQ 1171
+ GY G N ++ G Y + VV + +Q+ + GH +I +L +
Sbjct: 681 FIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKD 740
Query: 1172 VLASAS-GRSSTTAHCQIRVWDVSGGLCQHLIF-PHSTTVLALAFSPDDRLLVTLGDHDG 1229
+A+ GR + I VWD C L+ H V AL FS D + LV++G D
Sbjct: 741 YVATGQVGRDAA-----IHVWDTQTLKCLSLLKGQHQRGVCALDFSADGKCLVSVGLDDF 795
Query: 1230 RTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQ 1288
++ W + +++TR + + V NP +L VG + FW QQ G +
Sbjct: 796 HSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFW--QQAGGGFT-- 851
Query: 1289 VRREPVPEAVGAGELTSLC--YG-APPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIG 1345
+ +VG E T +C YG L++ G ++G + +W + + +A DG +
Sbjct: 852 -SKRGTFGSVGKLE-TMMCVSYGRMEDLVFSGAATGDIFIW--KDILLLKTVKAHDGPVF 907
Query: 1346 LLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKG--SGASSVFMEHELVLDGAVVSASFDD 1403
+ V+G G + LW L+ A S + L+ D + A
Sbjct: 908 AMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRA---- 963
Query: 1404 SVDMG----VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHCATCSEDGS 1458
+ +G +VGT G + + G T L+ GH +V + P CAT S+D +
Sbjct: 964 -ITLGHGHILVGTKNGEILEID-KSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKT 1021
Query: 1459 VRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAME 1518
+R+W L++ ++ + L + C A+S P+ + LA G DGS + +
Sbjct: 1022 LRIWELSAQHRMLAVRKLKKGGRCCAFS------PDGKALAVGLNDGSFLVVNADTVEDM 1075
Query: 1519 LKMHPHPVALTTVAFSTD-GQTVLSGDKDGLVAVSHPCT 1556
+ H ++ + FS D G+ + D V + + T
Sbjct: 1076 VSFHHRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLT 1114
Score = 85.9 bits (211), Expect = 3e-16
Identities = 120/542 (22%), Positives = 202/542 (37%), Gaps = 65/542 (11%)
Query: 276 PSPTASGRAALAPRPFPEVSLSQERSDASNADGPGFHS-LEPWAQLEASDIHTAAAGTHV 334
P ++G AP+ S S+E SD+ +D P S +E AQ+ D
Sbjct: 595 PEGVSNGMLETAPQEGGADSYSEE-SDSDLSDVPELDSDIEQEAQINY-DRQVYKEDLPQ 652
Query: 335 LTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVV 394
L +S E A P+ L+L+ + G+ G+ R L+ VVY AV VV
Sbjct: 653 LKQQSKEKNHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVV 712
Query: 395 LLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-M 453
QR +LGH D + +L + +A+ Q + + +WD QT +CL L +
Sbjct: 713 YNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQ 772
Query: 454 HVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVT 513
VC+L FS G L VG D + W GE + + H D + +
Sbjct: 773 RGVCALDFSADGKCLVSVGLDDFHSIVFWDWKK------GEKIATTRGHKD-KIFVVKCN 825
Query: 514 FFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAML 573
++ + G ++ W+ GG S G L+ T + R ++
Sbjct: 826 PHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVGKLE-TMMCVSYGR------MEDLV 878
Query: 574 FVCSRSGHIL---EIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPA 630
F + +G I +I + V H GP A+ +L
Sbjct: 879 FSGAATGDIFIWKDILLLKTVKAH---------------------DGPVFAMYALDKG-- 915
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRV-----LSATSSGHLGFL 685
G +DG + LW F L + S++ S GL + + A + GH G +
Sbjct: 916 -FVTGGKDGIVELWDDMFERCL--KTYAIKRSALSTSSKGLLLEDNPSIRAITLGH-GHI 971
Query: 686 DTLSRVYHMLARSHTAPVLALAMEQRRGQL------------ATVSQDRTVRIWDLATLQ 733
++ +L + P+ L G++ ATVS D+T+RIW+L+
Sbjct: 972 LVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQH 1031
Query: 734 QLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTAT 793
++ + F P G + G+ + + E +V + ++ + +
Sbjct: 1032 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFS 1091
Query: 794 PD 795
D
Sbjct: 1092 KD 1093
Score = 73.2 bits (178), Expect = 2e-12
Identities = 112/507 (22%), Positives = 186/507 (36%), Gaps = 56/507 (11%)
Query: 359 LRLKGVIGFGGHGTRQAL-WTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALAL 417
L L V G+ G R L + DGA +++ A +V + TG Q F+L HTD + L +
Sbjct: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
Query: 418 DGS---SSLLASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLSFSDSGALLCGVGK 473
+ +++A++Q + +WD T L + R V ++FS +G LL VG
Sbjct: 1423 NQHPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGV 1482
Query: 474 DHHGRTMVVAW--GTGQVGLGG--EVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVR 529
D V W G GG E + + + D D T+ S G ++
Sbjct: 1483 DPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSD-----------TQFVSVGVKHMK 1531
Query: 530 LWRLRGGVL---RSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEID 586
W L G L + LG +AF + + F + +G +
Sbjct: 1532 FWTLAGSALLYKKGVIGSLGAAKMQTMLSVAF---------GANNLTFTGAINGDVYVWK 1582
Query: 587 CQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPL 646
++ RL+ G T G L V+ E G ++LW
Sbjct: 1583 DHFLI-----RLVAKAHTGPVFTMYTTLRDG-------LIVTGGKERPTKEGGAVKLWDQ 1630
Query: 647 DFSSVLLEAEHEGP----VSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSH-TA 701
+ G V SVC ++L T G + + + ++L H
Sbjct: 1631 EMKRCRAFQLETGQLVECVRSVCRGKG--KILVGTKDGEIIEVGEKNAASNILIDGHMEG 1688
Query: 702 PVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGF 761
+ LA + + S D T RIWDLA + L + A CA + P G
Sbjct: 1689 EIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCA-AYSPDGEMVAIGM 1747
Query: 762 SSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVL 821
+G + + +V + + A+ + +PD R L S+ ++ Y ++
Sbjct: 1748 KNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGT-NLN 1806
Query: 822 RVAADMVCPDAPASPSALAVSRDGRLL 848
R+ C D P+ + S DG+ +
Sbjct: 1807 RIG---YCKDIPSFVIQMDFSADGKYI 1830
Score = 73.2 bits (178), Expect = 2e-12
Identities = 107/465 (23%), Positives = 182/465 (39%), Gaps = 56/465 (12%)
Query: 1108 LRLKAVVGYSG-NGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
L L V GY G + R N+ + D + +V++L +G+Q + H+ +I L +
Sbjct: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
Query: 1167 S-HSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFP----HSTTVLALAFSPDDRLL 1221
+ H A+ + TT I +WD + +H + HS V + FS +LL
Sbjct: 1423 NQHPKYRNVVATSQIGTTP--SIHIWDA---MTKHTLSMLRCFHSKGVNYINFSATGKLL 1477
Query: 1222 VTLGDHDGRTLALWGTATYDLVSST-RLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQ 1280
V++G T+ +W V+S E + V F P + VG + FW L
Sbjct: 1478 VSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAG 1537
Query: 1281 RGADISLQVRREPVPEAVGAGE---LTSLCYGAPPLLYCGTSSGQVCVW----------D 1327
S + ++ V ++GA + + S+ +GA L + G +G V VW
Sbjct: 1538 -----SALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKDHFLIRLVAK 1592
Query: 1328 TRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFME 1387
G F + G L+ +G + G ++LW RC+ +
Sbjct: 1593 AHTGPVFTMYTTLRDG---LIVTGGKERPTKEGGAVKLW---DQEMKRCRAFQLET---- 1642
Query: 1388 HELVLDGAVVSASFDDSVDMG--VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFS 1444
G +V G +VGT G + V S LI GH ++ +
Sbjct: 1643 ------GQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATH 1696
Query: 1445 PGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGD 1504
P + + S DG+ R+W LA +L+ + L + C A+S P+ + +A G +
Sbjct: 1697 PSKDLFISASNDGTARIWDLADKKLLNKVS-LGHAARCAAYS------PDGEMVAIGMKN 1749
Query: 1505 GSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLV 1549
G I V+ + K A+ + S D + + G + V
Sbjct: 1750 GEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTV 1794
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 150 bits (380), Expect = 8e-36
Identities = 285/1224 (23%), Positives = 448/1224 (36%), Gaps = 183/1224 (14%)
Query: 355 PDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSA 414
P LRL+ V G+ GH R L+ +VY V VV Q+F+ GH+D + +
Sbjct: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
Query: 415 LALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSP-MHVVCSLSFSDSGALLCGVGK 473
LAL L+A+ Q + +WD T + + + + H + L+F G L VG
Sbjct: 67 LALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGL 126
Query: 474 DHHGRTMVVAWGTGQVGLGGEVVVLAKAHTD--FDVQAFRVTFFDETRMASCGQGSVRLW 531
D V W G++ + +A HTD FD+ + ++ SCG ++ W
Sbjct: 127 DSKNAVCVWDWKRGKM------LSMAPGHTDRIFDISW---DLYQPNKLVSCGVKHIKFW 177
Query: 532 RLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMV 591
L G L G+ LQ T L ARD + + + +G I ++
Sbjct: 178 SLCGNALTPKRGVFGKTGDLQ-TILCLACARD-------ELTYSGALNGDIYVWKGINLI 229
Query: 592 VRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSV 651
RT G H I S++ A G DG +RLW L F +
Sbjct: 230 ----------RTIQGAH----------AAGIFSMNACEEGFATGGRDGCIRLWDLTFKPI 269
Query: 652 LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQR 711
+ E + G + LS S R H+L + + + + +++R
Sbjct: 270 TVIDLRE--------TDQGYKGLSVRS--------VCWRGDHILVGTQDSEIFEIVVQER 313
Query: 712 RGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSL 771
+ +W LA HPT+P G +VR +SL
Sbjct: 314 NKPFLIMQGHCEGELWALAV-------------------HPTKPLAVTGSDDRSVRIWSL 354
Query: 772 EAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMV--- 828
L+ + DG L GS VLRV DM
Sbjct: 355 -VDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFT----------VLRVR-DMTEVV 402
Query: 829 -CPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDL-------A 880
D + L S DG LA VG + +V + G A + + +G+L +
Sbjct: 403 HIKDRKEAIHELKYSPDGTYLA-VGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSS 461
Query: 881 SSRL----DSAMAVCFGPAALGHLLVSTSSNRVV---VLDAVSGRIIRELPGVHPEPCPS 933
SR D F G + ST + V VSG E+ G+ P+
Sbjct: 462 DSRYLQTNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGL---EVNGIWPKYSDI 518
Query: 934 LTL-SEDARFL---LIAAGR--TIKVWDYATQASPGP-QVYIGHSEPVQAVAFSPDQQQV 986
+ S D ++ L+ A IK++ Y + YIGHS V V +S D Q V
Sbjct: 519 NDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWV 578
Query: 987 LSAGDA---VFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPC 1043
+S G A VF W + + + AP L D+ S S+ VP+
Sbjct: 579 ISIGGADHSVFQWKFIPERKLKDAVHIAPQES--------LADSHSDESDSDLSDVPELD 630
Query: 1044 QASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPA 1103
+ R R P+ CK SA A
Sbjct: 631 SEIEQETQLTYR--------RQVYKEDLPQLK--EQCKE--------KQKSATSKRRERA 672
Query: 1104 SGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEIST 1163
G +RL V GY G + ++ G Y + V+ + Q+ + GH +I
Sbjct: 673 PGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILC 732
Query: 1164 LALSHSAQVLASAS-GRSSTTAHCQIRVWDVSG-GLCQHLIFPHSTTVLALAFSPDDRLL 1221
L + +A+ GR + I +WD L H V A+ FS D + L
Sbjct: 733 LTIHPLKDYVATGQVGRDPS-----IHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRL 787
Query: 1222 VTLGDHDGRTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQ 1280
++G D T+ LW + +S R + + V NP+ +L G + FW ++
Sbjct: 788 ASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFW--RK 845
Query: 1281 RGADISLQVRREPVPEAVGAGELTSLC--YG-APPLLYCGTSSGQVCVWDTRAGRCFLSW 1337
G + + R+ +G + T +C YG + + GTS+G VC+W R +
Sbjct: 846 AGGGL---IGRKGYIGTLGKND-TMMCAVYGWTEEMAFSGTSTGDVCIW--RDIFLVKTV 899
Query: 1338 EADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKG--SGASSVFMEHELVLDGA 1395
+A DG + + V+G G + LW L+ A + + L+ D
Sbjct: 900 KAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNP 959
Query: 1396 VVSASFDDSVDMG----VVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHC 1450
+ A + +G +VGT G + V G T L+ GH +V + P C
Sbjct: 960 SIRA-----ISLGHGHILVGTKNGEILEVD-KSGPITLLVQGHMEGEVWGLATHPYLPIC 1013
Query: 1451 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIF 1510
AT S+D ++R+W L+ ++ + L + C CC P+ + LA G DGS +
Sbjct: 1014 ATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRC------CCFSPDGKALAVGLNDGSFLMA 1067
Query: 1511 SVSRTAMELKMHPHPVALTTVAFS 1534
+ + H ++ + FS
Sbjct: 1068 NADTLEDLVSFHHRKDMISDIRFS 1091
Score = 76.3 bits (186), Expect = 3e-13
Identities = 110/477 (23%), Positives = 181/477 (37%), Gaps = 51/477 (10%)
Query: 354 LPDPVLRLKGVIGFGGHGTRQAL-WTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKV 412
+ D VL L + G+ G R + + DG ++Y +V ++ V TG Q F+ H D +
Sbjct: 1368 IEDLVLEL--IFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDI 1425
Query: 413 SALALDGSSSLL-----------ASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLS 460
L ++ + A A APS+ +WD + L + R VCS+S
Sbjct: 1426 LCLTVNQHPKFINIVATGQVGDSADMSATAPSI-HIWDAMNKQTLSILRCYHSKGVCSVS 1484
Query: 461 FSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRM 520
FS +G LL VG D + W G ++ A + V FR +T+
Sbjct: 1485 FSATGKLLLSVGLDPEHTITIWRWQE-----GAKIASRAGHNQRIFVAEFRPD--SDTQF 1537
Query: 521 ASCGQGSVRLWRLRGGVLRSCPVDLGE-HHALQFTDLAFKQARDGCPEPSAAMLFVCSRS 579
S G V+ W L G L S L A T LA + VC
Sbjct: 1538 VSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWK 1597
Query: 580 GHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDG 639
HIL C+ + R GP T + G+ ++ P+ E G
Sbjct: 1598 DHIL---CR----------IVARAHNGPVFAMYT-TLRDGLIVTGGKERPS-----KEGG 1638
Query: 640 FLRLWPLDFSSV----LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHML 695
++LW + L + V SVC ++L T + + + + ++L
Sbjct: 1639 AVKLWDQELRRCRAFRLETGQATDCVRSVCRGKG--KILVGTRNAEIIEVGEKNAACNIL 1696
Query: 696 ARSHT-APVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
H P+ LA R + ++D TVR+WD+A +++ + + A V + P
Sbjct: 1697 VNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIAD-KKMLNKVNLGHAARTVCYSPEG 1755
Query: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQY 811
G +G + + ++ + R A+ + +PD R L S+ S+ Y
Sbjct: 1756 DMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFY 1812
Score = 75.9 bits (185), Expect = 3e-13
Identities = 109/487 (22%), Positives = 191/487 (39%), Gaps = 63/487 (12%)
Query: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
L L+ + GY G R N+ + D Y + ++ ++ +G+Q + H+ +I L +
Sbjct: 1371 LVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTV 1430
Query: 1167 S-HSAQVLASASGRSSTTAHCQ-----IRVWDVSGGLCQHLI-FPHSTTVLALAFSPDDR 1219
+ H + A+G+ +A I +WD ++ HS V +++FS +
Sbjct: 1431 NQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGK 1490
Query: 1220 LLVTLGDHDGRTLALWGTAT-YDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFW-- 1276
LL+++G T+ +W + S + + F P + VG V FW
Sbjct: 1491 LLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTL 1550
Query: 1277 ----LLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGR 1332
LL ++G +L+ R + ++ +GA L + GT SG VCVW
Sbjct: 1551 AGRALLSKKGLLSTLEDARMQT--------MLAIAFGANNLTFTGTISGDVCVWKDHI-L 1601
Query: 1333 CFLSWEADDGGI---------GLLLFSGSRLVSGSSTGRLRLWAVGAVSEL-RCKG---- 1378
C + A +G + GL++ G S G ++LW EL RC+
Sbjct: 1602 CRIVARAHNGPVFAMYTTLRDGLIVTGGKERPS-KEGGAVKLWD----QELRRCRAFRLE 1656
Query: 1379 SGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGH-RSK 1437
+G ++ + G + +VGT + V L++GH
Sbjct: 1657 TGQATDCVRSVCRGKGKI------------LVGTRNAEIIEVGEKNAACNILVNGHVDGP 1704
Query: 1438 VNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQR 1497
+ + P + +EDG+VR+W +A ++ LN+ L A + C PE
Sbjct: 1705 IWGLATHPSRDFFLSAAEDGTVRLWDIADKKM------LNKVNLGHA-ARTVCYSPEGDM 1757
Query: 1498 LAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTG 1557
+A G +G I VS + K A+ + FS D + + G + V G
Sbjct: 1758 VAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLG 1817
Query: 1558 TTFRVLS 1564
T +S
Sbjct: 1818 PTLNRIS 1824
Score = 72.0 bits (175), Expect = 5e-12
Identities = 105/526 (19%), Positives = 190/526 (36%), Gaps = 63/526 (11%)
Query: 292 PEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTH---VLTHESAEVPVARTG 348
P+ SL+ SD S++D L+ + E + L + E + T
Sbjct: 607 PQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATS 666
Query: 349 SCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGH 408
P +RL V G+ G+ R L+ +VY AV V+ QRF+LGH
Sbjct: 667 KRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGH 726
Query: 409 TDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRS-PMHVVCSLSFSDSGAL 467
D + L + +A+ Q + +WD +T + L + + + V ++ FS G
Sbjct: 727 DDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKR 786
Query: 468 LCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGS 527
L VG D ++ W GE + +A+ D + ++ + ++ + G
Sbjct: 787 LASVGIDDSHTVVLWDWKK------GEKLSIARGSKD-KIFVVKMNPYVPDKLITAGIKH 839
Query: 528 VRLWRLRGGVL---RSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILE 584
++ WR GG L + LG++ + + + M F + +G +
Sbjct: 840 MKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTE----------EMAFSGTSTGDV-- 887
Query: 585 IDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLW 644
+ R + + GP + S+ G +DG + LW
Sbjct: 888 -----CIWRDIFLVKTVKAHDGP--------------VFSMHALEKGFVTGGKDGIVALW 928
Query: 645 PLDFSSVL----LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHT 700
F L ++ P S + D + A S GH G + ++ +L +
Sbjct: 929 DDSFERCLKTYAIKRAALAPGSKGLLLEDNPSI-RAISLGH-GHILVGTKNGEILEVDKS 986
Query: 701 APVLALAMEQRRGQL------------ATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAV 748
P+ L G++ ATVS D+T+RIWDL+ + +
Sbjct: 987 GPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCC 1046
Query: 749 TFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATP 794
F P G + G+ + + E LV + ++ + +P
Sbjct: 1047 CFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSP 1092
Score = 61.6 bits (148), Expect = 6e-09
Identities = 101/458 (22%), Positives = 169/458 (36%), Gaps = 48/458 (10%)
Query: 1108 LRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALS 1167
LRL+ V GY G+ N ++ Y + VV Q+ + GHS +I +LAL
Sbjct: 11 LRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLAL- 69
Query: 1168 HSAQVLASASGRSSTTAHCQIRVWD-VSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGD 1226
H +VL A+G+ + I +WD + L H+ + LAF D + LV++G
Sbjct: 70 HPERVLV-ATGQVGKEPY--ICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGL 126
Query: 1227 HDGRTLALWGTATYDLVS-STRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADI 1285
+ +W ++S + + + ++++ + +L G + FW L
Sbjct: 127 DSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSL----CGN 182
Query: 1286 SLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIG 1345
+L +R + + L L Y G +G + VW A GI
Sbjct: 183 ALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLIRTIQGAHAAGIF 241
Query: 1346 LLLFSGSRLVSGSSTGRLRLWAVG----AVSELR-----CKGSGASSVFMEHELVLDGAV 1396
+ +G G +RLW + V +LR KG SV + +L G
Sbjct: 242 SMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQ 301
Query: 1397 VSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGH-RSKVNEVVFSPGESHCATCSE 1455
S F+ V ++ GH ++ + P + T S+
Sbjct: 302 DSEIFE----------------IVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSD 345
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCG--RPEQQRLAAGYGDGSLRIFSVS 1513
D SVR+W+L L+ + C P C + LA G DGS + V
Sbjct: 346 DRSVRIWSLVDHALIAR---------CNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVR 396
Query: 1514 RTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
+ + A+ + +S DG + G D V +
Sbjct: 397 DMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDI 434
Score = 32.3 bits (72), Expect = 4.2
Identities = 27/113 (23%), Positives = 42/113 (37%)
Query: 636 SEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHML 695
+EDG +RLW + +L + +VC SP+G V +G L S
Sbjct: 1721 AEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGK 1780
Query: 696 ARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAV 748
R + + LA S + +V +DL L + +D P V
Sbjct: 1781 KRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFV 1833
>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
sapiens]
Length = 620
Score = 112 bits (279), Expect = 4e-24
Identities = 134/650 (20%), Positives = 247/650 (38%), Gaps = 61/650 (9%)
Query: 359 LRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALD 418
L L VIGF GH PD ++YP +++ ++T EQ F GH + VS LA+
Sbjct: 14 LELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNNVSCLAIS 73
Query: 419 GSSSLLASAQARAPSVMR---LWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDH 475
S +AS Q LWD++ L + +L+FS + L +G
Sbjct: 74 RSGEYIASGQVTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPD 133
Query: 476 HGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETR---MASCGQGSVRLWR 532
G VV W + + +V F R + G G++R+W
Sbjct: 134 DGS--VVVWSIAK-----RDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWE 186
Query: 533 LRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVV 592
L + P E Q + D + ++ + +G IL+++ + ++
Sbjct: 187 LDLPNRKIWPT---ECQTGQLKRIVMSIGVDD----DDSFFYLGTTTGDILKMNPRTKLL 239
Query: 593 RHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVL 652
P K FS G AI L + + VGS G L +
Sbjct: 240 TDVG------------PAKDKFSLGVS-AIRCLKMGGLL--VGSGAGLLVFCKSPGYKPI 284
Query: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
+ + +G ++S+ + +G + L T H+ + ++A H V +
Sbjct: 285 KKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGT 344
Query: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLE 772
+L + +R+W ++ ++L T + F + ++ G +R+F+ E
Sbjct: 345 AELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPE 404
Query: 773 AAEVL-VEHTCHRGAVTGLTATPDGRLLFSSCSQGSLA--QYSCADPQWHVLRVAADMVC 829
++ V + HR VT + T D + + S +G + Q C + +
Sbjct: 405 TGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQK-------LEEAL 457
Query: 830 PDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMA 889
+ +S S + V R+ T + G+ + +L+R+ + LA++
Sbjct: 458 KEHKSSVSCIRVKRNNEECV-------TASTDGTCIIWDLVRLRRNQMILANTLFQ---C 507
Query: 890 VCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDA-RFLLIAAG 948
VC+ P ++ S + ++ + G +IREL G + ++++ F+
Sbjct: 508 VCYHPEEF-QIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND 566
Query: 949 RTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQV--LSAGDAVFLW 996
+KVWDY V +GHS + + SP Q + +SA A+ W
Sbjct: 567 HLVKVWDY--NEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Score = 108 bits (270), Expect = 5e-23
Identities = 121/514 (23%), Positives = 206/514 (40%), Gaps = 61/514 (11%)
Query: 1101 PPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAE 1160
P A L L AV+G++G+ + PD Y G V+++ +++ Q GH
Sbjct: 7 PEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLGCTVLIQAINTKEQNFLQGHGNN 66
Query: 1161 ISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRL 1220
+S LA+S S + +AS + I +WD + H + ALAFSP+D
Sbjct: 67 VSCLAISRSGEYIASGQ-VTFMGFKADIILWDYKNRELLARLSLHKGKIEALAFSPNDLY 125
Query: 1221 LVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHG--------VAFNPWDAGELTCVGQGT 1272
LV+LG D ++ +W A D + + P G V F+ G GT
Sbjct: 126 LVSLGGPDDGSVVVWSIAKRDAICGS----PAAGLNVGNATNVIFSRCRDEMFMTAGNGT 181
Query: 1273 VTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-----PPLLYCGTSSGQVCVWD 1327
+ W L R+ P G+L + Y GT++G + +
Sbjct: 182 IRVWELD--------LPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMN 233
Query: 1328 TRAGRCFLSWEADD----GGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASS 1383
R A D G + L+ GS G L + CK G
Sbjct: 234 PRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLL----------VFCKSPGYKP 283
Query: 1384 VFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVF 1443
+ ++ L G + S + +VGT ++ VS+ + T + + H V ++VF
Sbjct: 284 I---KKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVF 340
Query: 1444 SPGESHC-ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGY 1502
G + ATC++ +RVW +S +++ V N +C + + + + + + +
Sbjct: 341 PFGTAELFATCAKK-DIRVWHTSSNRELLRITVPNMTCHGIDF------MRDGKSIISAW 393
Query: 1503 GDGSLRIFS-VSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV-SHPC-TGTT 1559
DG +R F+ + M + + H + +T +A ++D + V+SG +G V V C T
Sbjct: 394 NDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQTQKL 453
Query: 1560 FRVLSDHQGAPISTICVTCK----ECEDLGVEGT 1589
L +H+ S C+ K EC +GT
Sbjct: 454 EEALKEHKS---SVSCIRVKRNNEECVTASTDGT 484
Score = 31.2 bits (69), Expect = 9.2
Identities = 23/84 (27%), Positives = 33/84 (39%), Gaps = 12/84 (14%)
Query: 1391 VLDGAVV---------SASFDDSVDMGVVGTTAGTLWFVS---WAEGTSTRLISGHRSKV 1438
V DG V+ S + D GV T G V + EG T + GH +
Sbjct: 531 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 590
Query: 1439 NEVVFSPGESHCATCSEDGSVRVW 1462
+ SPG + + S DG++ W
Sbjct: 591 TRIRISPGNQYIVSVSADGAILRW 614
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 92.8 bits (229), Expect = 3e-18
Identities = 107/465 (23%), Positives = 176/465 (37%), Gaps = 58/465 (12%)
Query: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413
LP L+L+ V G+ G R L+ +VY +V V+ V+ QR +LGH D +
Sbjct: 50 LPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIK 109
Query: 414 ALALDGSSSLLASAQARA--------PSVMRLWDFQTGRCLCLFRSPM--HVVCSLSFSD 463
LA+ +A+ Q P +R+WD + L + + VC + FS
Sbjct: 110 CLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSK 169
Query: 464 S--GALLCGVGKDHHGRTMVVAWG----TGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDE 517
S G LLC V + + V W V E V++A H D
Sbjct: 170 SNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPT-----------DP 218
Query: 518 TRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFT-DLAFKQARDGCPEPSAAMLFVC 576
T + +CG+ + W L GG L +H ++ + F + D S L+V
Sbjct: 219 TVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVW 278
Query: 577 SRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGS 636
+ G+ + T+ G H G + +L + + G
Sbjct: 279 GKGGNRI-----------------TQAVLGAH-------DGGVFGLCALR-DGTLVSGGG 313
Query: 637 EDGFLRLWPLDFSSV--LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 694
D + LW D+S + + E GPV +V + T + L ++ + +
Sbjct: 314 RDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSIL--QGSVHTGFSL 371
Query: 695 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
L + H + LA R Q T QD+ V +W + Q L+ ED + FHP+
Sbjct: 372 LVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWS-RIIEDPARSAGFHPSG 430
Query: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLL 799
G +G E +++ HT ++ ++ +PDG L
Sbjct: 431 SVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYL 475
Score = 76.6 bits (187), Expect = 2e-13
Identities = 113/461 (24%), Positives = 179/461 (38%), Gaps = 46/461 (9%)
Query: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
L+L+ V GY G RAN+ P TG Y + V+ + Q+H+ GH+ +I LA+
Sbjct: 55 LKLEWVYGYRGRDCRANLYLLP-TGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
Query: 1167 SHSAQVLASASGRSSTTAHCQ-----IRVWDVSGGLCQHL----IFPHSTTVLALAFSPD 1217
H V + + TT + +R+WD H+ +F + + + S
Sbjct: 114 -HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNG 172
Query: 1218 DRLLVTLGDHDGRTLALWGTATYDLVSSTRLP-EPVHGVAFNPWDAGELTCVGQGTVTFW 1276
LL + + + L++W A V + E V F+P D L G+ + FW
Sbjct: 173 GNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFW 232
Query: 1277 LLQQRGADISLQ---VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRC 1333
L+ G +S + + P+ V +T L G + G S G + VW R
Sbjct: 233 TLE--GGSLSKRQGLFEKHEKPKYVLC--VTFLEGGD---VVTGDSGGNLYVWGKGGNRI 285
Query: 1334 FLS-WEADDGGI-GLLLFSGSRLVSGSSTG-RLRLWAVGAVSELRCKGSGASSVFMEHEL 1390
+ A DGG+ GL LVSG R+ LW GS S + E E+
Sbjct: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLW-----------GSDYSKL-QEVEV 333
Query: 1391 VLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHC 1450
D V + D VGTT ++ S G S L+ GH ++ + P +
Sbjct: 334 PEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSL-LVQGHVEELWGLATHPSRAQF 392
Query: 1451 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIF 1510
TC +D V +W+ S + + +++ + P LA G G +
Sbjct: 393 VTCGQDKLVHLWSSDSHQ-PLWSRIIEDPARSAGF------HPSGSVLAVGTVTGRWLLL 445
Query: 1511 SVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
+ ++ V+FS DG + G D LV V
Sbjct: 446 DTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYV 486
>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
sapiens]
Length = 552
Score = 76.6 bits (187), Expect = 2e-13
Identities = 98/427 (22%), Positives = 167/427 (39%), Gaps = 60/427 (14%)
Query: 1188 IRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTR 1247
I +WD + H + ALAFSP+D LV+LG D ++ +W A D + +
Sbjct: 25 IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGS- 83
Query: 1248 LPEPVHG--------VAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVG 1299
P G V F+ G GT+ W L R+ P
Sbjct: 84 ---PAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPN--------RKIWPTECQ 132
Query: 1300 AGELTSLCYGA-----PPLLYCGTSSGQVCVWDTRAGRCFLSWEADD----GGIGLLLFS 1350
G+L + Y GT++G + + R A D G +
Sbjct: 133 TGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLK 192
Query: 1351 GSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVV 1410
L+ GS G L + CK G + ++ L G + S + +V
Sbjct: 193 MGGLLVGSGAGLL----------VFCKSPGYKPI---KKIQLQGGITSITLRGEGHQFLV 239
Query: 1411 GTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHC-ATCSEDGSVRVWALASMEL 1469
GT ++ VS+ + T + + H V ++VF G + ATC++ +RVW +S
Sbjct: 240 GTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKK-DIRVWHTSSNRE 298
Query: 1470 VIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFS-VSRTAMELKMHPHPVAL 1528
+++ V N +C + + + + + + + DG +R F+ + M + + H + +
Sbjct: 299 LLRITVPNMTCHGIDF------MRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGV 352
Query: 1529 TTVAFSTDGQTVLSGDKDGLVAV-SHPC-TGTTFRVLSDHQGAPISTICVTCK----ECE 1582
T +A ++D + V+SG +G V V C T L +H+ S C+ K EC
Sbjct: 353 TAIATTSDCKRVISGGGEGEVRVWQIGCQTQKLEEALKEHKS---SVSCIRVKRNNEECV 409
Query: 1583 DLGVEGT 1589
+GT
Sbjct: 410 TASTDGT 416
Score = 73.6 bits (179), Expect = 2e-12
Identities = 108/569 (18%), Positives = 211/569 (37%), Gaps = 58/569 (10%)
Query: 437 LWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVV 496
LWD++ L + +L+FS + L +G G VV W +
Sbjct: 27 LWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGS--VVVWSIAK-----RDA 79
Query: 497 VLAKAHTDFDVQAFRVTFFDETR---MASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQF 553
+ +V F R + G G++R+W L + P E Q
Sbjct: 80 ICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPT---ECQTGQL 136
Query: 554 TDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQT 613
+ D + ++ + +G IL+++ + ++ P K
Sbjct: 137 KRIVMSIGVDD----DDSFFYLGTTTGDILKMNPRTKLLTDVG------------PAKDK 180
Query: 614 FSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRV 673
FS G AI L + + VGS G L + + + +G ++S+ + +G +
Sbjct: 181 FSLGVS-AIRCLKMGGLL--VGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQF 237
Query: 674 LSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQ 733
L T H+ + ++A H V + +L + +R+W ++ +
Sbjct: 238 LVGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNR 297
Query: 734 QLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVL-VEHTCHRGAVTGLTA 792
+L T + F + ++ G +R+F+ E ++ V + HR VT +
Sbjct: 298 ELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINNAHRIGVTAIAT 357
Query: 793 TPDGRLLFSSCSQGSLA--QYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAF 850
T D + + S +G + Q C + + + +S S + V R+
Sbjct: 358 TSDCKRVISGGGEGEVRVWQIGCQTQK-------LEEALKEHKSSVSCIRVKRNNEECV- 409
Query: 851 VGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVV 910
T + G+ + +L+R+ + LA++ VC+ P ++ S + ++
Sbjct: 410 ------TASTDGTCIIWDLVRLRRNQMILANTLFQ---CVCYHPEEF-QIITSGTDRKIA 459
Query: 911 VLDAVSGRIIRELPGVHPEPCPSLTLSEDA-RFLLIAAGRTIKVWDYATQASPGPQVYIG 969
+ G +IREL G + ++++ F+ +KVWDY V +G
Sbjct: 460 YWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDY--NEGEVTHVGVG 517
Query: 970 HSEPVQAVAFSPDQQQV--LSAGDAVFLW 996
HS + + SP Q + +SA A+ W
Sbjct: 518 HSGNITRIRISPGNQYIVSVSADGAILRW 546
Score = 31.2 bits (69), Expect = 9.2
Identities = 23/84 (27%), Positives = 33/84 (39%), Gaps = 12/84 (14%)
Query: 1391 VLDGAVV---------SASFDDSVDMGVVGTTAGTLWFVS---WAEGTSTRLISGHRSKV 1438
V DG V+ S + D GV T G V + EG T + GH +
Sbjct: 463 VFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNI 522
Query: 1439 NEVVFSPGESHCATCSEDGSVRVW 1462
+ SPG + + S DG++ W
Sbjct: 523 TRIRISPGNQYIVSVSADGAILRW 546
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 75.5 bits (184), Expect = 4e-13
Identities = 100/426 (23%), Positives = 168/426 (39%), Gaps = 95/426 (22%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFS 1215
GHS + ++A S + + LAS SG ++ +R WD+S H VL++++S
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTT------VRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 1216 PDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTF 1275
PD R L + G +G+ L LW +T V T + W G
Sbjct: 166 PDGRKLAS-GCKNGQIL-LWDPSTGKQVGRTL-------AGHSKWITG------------ 204
Query: 1276 WLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS--GQVCVWDTRAGRC 1333
+ EP+ + P Y +SS G V +WDT AGRC
Sbjct: 205 -------------LSWEPL-------------HANPECRYVASSSKDGSVRIWDTTAGRC 238
Query: 1334 FLSWEADDGGIGLLLFSGSRLVSGSSTGR-LRLW-AVGAVSELRCKGSG----------- 1380
+ L + G L+ +S R +++W A V +G G
Sbjct: 239 ERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD 298
Query: 1381 ---ASSVFMEHELVLDGAVVSASFDDSVDMG---------------VVGTTAGTLWFVSW 1422
+ F E ++ + S + + V G+ TL+ S
Sbjct: 299 YALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSP 358
Query: 1423 AEGTS--TRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSC 1480
AE TR+ +GH++ +N+V+FSP A+ S D S+++W + + + + +
Sbjct: 359 AEDKKPLTRM-TGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAV 417
Query: 1481 LCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTV 1540
+AWS + + L +G D +L+++ V + + + H + V +S DGQ V
Sbjct: 418 YQIAWS------ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRV 471
Query: 1541 LSGDKD 1546
SG KD
Sbjct: 472 ASGGKD 477
Score = 57.0 bits (136), Expect = 2e-07
Identities = 98/420 (23%), Positives = 150/420 (35%), Gaps = 74/420 (17%)
Query: 374 QALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPS 433
QA+ T ++Y A+ V V T GH++ V ++A + LAS +
Sbjct: 80 QAVETEKVLDIIYQPQAIFRVRAV-TRCTSSLEGHSEAVISVAFSPTGKYLASGSG--DT 136
Query: 434 VMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHH------------GRTMV 481
+R WD T + H V S+S+S G L K+ GRT+
Sbjct: 137 TVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLA 196
Query: 482 --VAWGTG----QVGLGGEVVVLAKAHTDFDVQAFRVT-------FFDETRMASC----G 524
W TG + E +A + D V+ + T T+ +C G
Sbjct: 197 GHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG 256
Query: 525 QG---------SVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQA-RDGCPEPSAAMLF 574
G ++++WR GVL C G H + L+ A R G EP+ A +
Sbjct: 257 DGLLYSASQDRTIKVWRAHDGVL--CRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVN 314
Query: 575 VCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAV 634
G + E+ +R + R+ G G P
Sbjct: 315 PQDLQGSLQELK-ERALSRY------------------NLVRGQG---------PERLVS 346
Query: 635 GSEDGFLRLW-PLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVY 692
GS+D L LW P + L H+ ++ V SPD V SA+ + D + Y
Sbjct: 347 GSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406
Query: 693 HMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHP 752
R H A V +A L + S D T+++WD+ + D D AV + P
Sbjct: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSP 466
Score = 51.6 bits (122), Expect = 7e-06
Identities = 83/359 (23%), Positives = 141/359 (39%), Gaps = 63/359 (17%)
Query: 1428 TRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP 1487
T + GH V V FSP + A+ S D +VR W L++ + L ++WS
Sbjct: 107 TSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS- 165
Query: 1488 PCCGRPEQQRLAAGYGDGSLRIF------SVSRTAMELKMHPHPVALTTVAFSTDGQTVL 1541
P+ ++LA+G +G + ++ V RT ++ + + + + V
Sbjct: 166 -----PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVA 220
Query: 1542 SGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRV 1601
S KDG V + G R+L+ H T VTC L G L +AS D+ +
Sbjct: 221 SSSKDGSVRIWDTTAGRCERILTGH------TQSVTC-----LRWGGDGLLYSASQDRTI 269
Query: 1602 SVWASD------WLRNHCELVDWLSFPMPATTETQGHLPPSLAAFCPWD--GALLMYVGP 1653
VW + L+ H V+ ++ T G P+ A+ P D G+L
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRT-GAFEPAEASVNPQDLQGSLQELKER 328
Query: 1654 GVYKEVIIYNLCQKQVVEKI-----------------PLPFFAMS--------LSLSPGT 1688
+ + YNL + Q E++ P M+ + SP +
Sbjct: 329 ALSR----YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS 384
Query: 1689 HLLAVGFAECMLRLVDCAMGT-AQDFAGHDNAVHLCRFTPSARLLFTAARNEIL-VWEV 1745
++A + ++L D G GH AV+ ++ +RLL + + + L VW+V
Sbjct: 385 RIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Score = 50.4 bits (119), Expect = 1e-05
Identities = 87/374 (23%), Positives = 143/374 (38%), Gaps = 51/374 (13%)
Query: 657 HEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLA 716
H V SV SP G + S + + F D + H + H VL+++ +LA
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 717 TVSQDRTVRIWDLATLQQLYDFTSSEDA-PCAVTFHPTRPTFFCGF-----SSGAVRSFS 770
+ ++ + +WD +T +Q+ + +++ P C + G+VR +
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 771 LEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYS------CADPQWH----- 819
A T H +VT L DG LL+S+ ++ + C Q H
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 820 VLRVAADMVCPDAPASPSALAVSRDG----------------RLLAFVGPSRCTVTVMGS 863
+ ++ D P+ +V+ L+ GP R V GS
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERL---VSGS 348
Query: 864 ASLDELL---RVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVL-DAVSGRI 919
L D L + V F P + ++ S S ++ + L D +G+
Sbjct: 349 DDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS--RIVASASFDKSIKLWDGRTGKY 406
Query: 920 IRELPGVHPEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQ--ASPGPQVYIGHSEPVQA 976
+ L G H + S D+R L+ + T+KVWD Q A P GH++ V A
Sbjct: 407 LASLRG-HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP----GHADEVYA 461
Query: 977 VAFSPDQQQVLSAG 990
V +SPD Q+V S G
Sbjct: 462 VDWSPDGQRVASGG 475
Score = 47.8 bits (112), Expect = 1e-04
Identities = 91/384 (23%), Positives = 147/384 (38%), Gaps = 81/384 (21%)
Query: 927 HPEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQASPGPQVYI-GHSEPVQAVAFSPDQQ 984
H E S+ S ++L +G T++ WD +T+ P GH V ++++SPD +
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTET---PHFTCKGHRHWVLSISWSPDGR 169
Query: 985 QVLSA--GDAVFLWDVLAPTESDQSFPG--------------APPACKTGPGAGPLEDAA 1028
++ S + LWD + ++ G A P C+ A +D +
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYV--ASSSKDGS 227
Query: 1029 SRASELPRQQVPKPCQASPPRLGVCARPPEGGDG----ARDTR----------------- 1067
R + + + + C R GGDG A R
Sbjct: 228 VRIWDTTAGRCERILTGHTQSV-TCLR--WGGDGLLYSASQDRTIKVWRAHDGVLCRTLQ 284
Query: 1068 ------NSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYS---G 1118
N+ A T Y AF PA S +P +G+ L+ +A+ Y+ G
Sbjct: 285 GHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQE------LKERALSRYNLVRG 338
Query: 1119 NGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASG 1178
G +V +G +T ED + +GH A I+ + S ++++ASAS
Sbjct: 339 QGPERLV----SGSDDFTLFLWSPAEDKKPLTRM--TGHQALINQVLFSPDSRIVASASF 392
Query: 1179 RSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTA 1238
S I++WD G + H V +A+S D RLLV+ G D TL +W
Sbjct: 393 DKS------IKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVS-GSSDS-TLKVWDVK 444
Query: 1239 TYDLVSSTRLP---EPVHGVAFNP 1259
L LP + V+ V ++P
Sbjct: 445 AQKLAMD--LPGHADEVYAVDWSP 466
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/173 (23%), Positives = 75/173 (43%), Gaps = 3/173 (1%)
Query: 1395 AVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCS 1454
AV+S +F + G+ T+ F + T GHR V + +SP A+
Sbjct: 116 AVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGC 175
Query: 1455 EDGSVRVWALASMELVIQFQVLNQSCLC-LAWSPPCCGRPEQQRLAAGYGDGSLRIFSVS 1513
++G + +W ++ + V + + + L+W P PE + +A+ DGS+RI+ +
Sbjct: 176 KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE-PLHANPECRYVASSSKDGSVRIWDTT 234
Query: 1514 RTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDH 1566
E + H ++T + + DG + S +D + V G R L H
Sbjct: 235 AGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286
Score = 36.2 bits (82), Expect = 0.29
Identities = 79/339 (23%), Positives = 120/339 (35%), Gaps = 56/339 (16%)
Query: 1250 EPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYG 1309
E V VAF+P + G TV FW L + + R V + + L G
Sbjct: 115 EAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASG 174
Query: 1310 APPLLYCGTSSGQVCVWDTRAGR-------------CFLSWEADDGGIGLLLFSGSRLVS 1356
+GQ+ +WD G+ LSWE L R V+
Sbjct: 175 C--------KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP------LHANPECRYVA 220
Query: 1357 GSS-TGRLRLWAVGAVSELRCKG--SGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTT 1413
SS G +R+W A RC+ +G + DG + SAS D ++
Sbjct: 221 SSSKDGSVRIWDTTAG---RCERILTGHTQSVTCLRWGGDGLLYSASQDRTI-------- 269
Query: 1414 AGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE--DGSVRVWALASMELVI 1471
+W +G R + GH VN + S + E + SV L +
Sbjct: 270 --KVWRAH--DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQEL 325
Query: 1472 QFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMEL-KMHPHPVALTT 1530
+ + L++ L P +RL +G D +L ++S + L +M H +
Sbjct: 326 KERALSRYNLVRGQGP--------ERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQ 377
Query: 1531 VAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGA 1569
V FS D + V S D + + TG L H A
Sbjct: 378 VLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAA 416
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 73.6 bits (179), Expect = 2e-12
Identities = 101/481 (20%), Positives = 169/481 (35%), Gaps = 58/481 (12%)
Query: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413
LP L+L+ V G+ G R L+ VY +V+V+ V+ QR + GH D V
Sbjct: 235 LPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVK 294
Query: 414 ALALDGSSSLLASAQA--------RAPSVMRLWDFQTGRCLCL----FRSPMHVVCSLSF 461
LA+ +A+ Q + P +R+WD T L + F + S
Sbjct: 295 CLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSK 354
Query: 462 SDSGALLCGVGKDHHGRTMVVAW----GTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDE 517
S+ G LC V + V W V E V A H D
Sbjct: 355 SNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-----------DT 403
Query: 518 TRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFT-DLAFKQARDGCPEPSAAMLFVC 576
+ +CG+ + W L G L + +F + F + D S+ + V
Sbjct: 404 NIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVW 463
Query: 577 SRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGS 636
+ + + Q G H GI + + + G
Sbjct: 464 GKGTNRISYAVQ-----------------GAHE--------GGIFALCMLRDGTLVSGGG 498
Query: 637 EDGFLRLWPLDFSSVLLE--AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 694
+D L W ++ + E GP+ +V + ++ T + L TLS +
Sbjct: 499 KDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVL--QGTLSGDFTP 556
Query: 695 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
+ + HT + LA+ + Q T D+ +WD + ++D ED + FHP+
Sbjct: 557 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWD-KIIEDPAQSSGFHPSG 615
Query: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCA 814
G +G F E +++ HT ++ + +PDG L + Y +
Sbjct: 616 SVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVS 675
Query: 815 D 815
D
Sbjct: 676 D 676
Score = 73.2 bits (178), Expect = 2e-12
Identities = 78/369 (21%), Positives = 146/369 (39%), Gaps = 33/369 (8%)
Query: 1108 LRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALS 1167
L+L+ V GY G N ++ TG Y +VV+ ++ Q+H++GH+ ++ LA+
Sbjct: 240 LKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVH 299
Query: 1168 HSAQVLA----SASGRSSTTAHCQIRVWDVSGGLCQHLI----FPHSTTVLALAFSPDDR 1219
+A + + + +R+WD H+I F + T +A + S
Sbjct: 300 PDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGT 359
Query: 1220 LLVTLGDHDGRTLALWGTATYDLVSSTRLP-EPVHGVAFNPWDAGELTCVGQGTVTFWLL 1278
L + D + L++W + ++ + E V F+P D + G+ + FW L
Sbjct: 360 NLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTL 419
Query: 1279 QQRGADISLQ---VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFL 1335
+ G+ ++ + ++ P+ V + + G SSG + VW R
Sbjct: 420 E--GSSLNKKQGLFEKQEKPKFV-----LCVTFSENGDTITGDSSGNILVWGKGTNRISY 472
Query: 1336 SWE-ADDGGI-GLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLD 1393
+ + A +GGI L + LVSG R + G +LR + E+
Sbjct: 473 AVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLR-----------KTEIPEQ 521
Query: 1394 GAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATC 1453
+ + D+ ++GTT + G T + GH ++ + +S TC
Sbjct: 522 FGPIRTVAEGKGDVILIGTTRNFV-LQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTC 580
Query: 1454 SEDGSVRVW 1462
D +W
Sbjct: 581 GHDKHATLW 589
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 73.6 bits (179), Expect = 2e-12
Identities = 101/481 (20%), Positives = 169/481 (35%), Gaps = 58/481 (12%)
Query: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413
LP L+L+ V G+ G R L+ VY +V+V+ V+ QR + GH D V
Sbjct: 216 LPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVK 275
Query: 414 ALALDGSSSLLASAQA--------RAPSVMRLWDFQTGRCLCL----FRSPMHVVCSLSF 461
LA+ +A+ Q + P +R+WD T L + F + S
Sbjct: 276 CLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSK 335
Query: 462 SDSGALLCGVGKDHHGRTMVVAW----GTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDE 517
S+ G LC V + V W V E V A H D
Sbjct: 336 SNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPT-----------DT 384
Query: 518 TRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFT-DLAFKQARDGCPEPSAAMLFVC 576
+ +CG+ + W L G L + +F + F + D S+ + V
Sbjct: 385 NIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVW 444
Query: 577 SRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGS 636
+ + + Q G H GI + + + G
Sbjct: 445 GKGTNRISYAVQ-----------------GAHE--------GGIFALCMLRDGTLVSGGG 479
Query: 637 EDGFLRLWPLDFSSVLLE--AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 694
+D L W ++ + E GP+ +V + ++ T + L TLS +
Sbjct: 480 KDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVL--QGTLSGDFTP 537
Query: 695 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
+ + HT + LA+ + Q T D+ +WD + ++D ED + FHP+
Sbjct: 538 ITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWD-KIIEDPAQSSGFHPSG 596
Query: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCA 814
G +G F E +++ HT ++ + +PDG L + Y +
Sbjct: 597 SVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVS 656
Query: 815 D 815
D
Sbjct: 657 D 657
Score = 73.2 bits (178), Expect = 2e-12
Identities = 78/369 (21%), Positives = 146/369 (39%), Gaps = 33/369 (8%)
Query: 1108 LRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALS 1167
L+L+ V GY G N ++ TG Y +VV+ ++ Q+H++GH+ ++ LA+
Sbjct: 221 LKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVH 280
Query: 1168 HSAQVLA----SASGRSSTTAHCQIRVWDVSGGLCQHLI----FPHSTTVLALAFSPDDR 1219
+A + + + +R+WD H+I F + T +A + S
Sbjct: 281 PDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGT 340
Query: 1220 LLVTLGDHDGRTLALWGTATYDLVSSTRLP-EPVHGVAFNPWDAGELTCVGQGTVTFWLL 1278
L + D + L++W + ++ + E V F+P D + G+ + FW L
Sbjct: 341 NLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTL 400
Query: 1279 QQRGADISLQ---VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFL 1335
+ G+ ++ + ++ P+ V + + G SSG + VW R
Sbjct: 401 E--GSSLNKKQGLFEKQEKPKFV-----LCVTFSENGDTITGDSSGNILVWGKGTNRISY 453
Query: 1336 SWE-ADDGGI-GLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLD 1393
+ + A +GGI L + LVSG R + G +LR + E+
Sbjct: 454 AVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLR-----------KTEIPEQ 502
Query: 1394 GAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATC 1453
+ + D+ ++GTT + G T + GH ++ + +S TC
Sbjct: 503 FGPIRTVAEGKGDVILIGTTRNFV-LQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTC 561
Query: 1454 SEDGSVRVW 1462
D +W
Sbjct: 562 GHDKHATLW 570
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 73.2 bits (178), Expect = 2e-12
Identities = 130/615 (21%), Positives = 223/615 (36%), Gaps = 76/615 (12%)
Query: 221 HVRFPSESLKVPSKPIEKSCSPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTA 280
HV +S+ +P ++ P + G G A+ KP S + + ++
Sbjct: 58 HVASVKKSVSSKGQPSPRAVIPMSCITNGSG--------ANRKPSHTSAVSIAGKETLSS 109
Query: 281 SGRAALAPRPFPEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESA 340
+ ++ P P + S E SD S + +L TA V+ ++
Sbjct: 110 AAKSIKRPSPAEKSHNSWENSDDSRNK---LSKIPSTPKLIPKVTKTADKHKDVIINQEG 166
Query: 341 E--------------VP--VARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAV 384
E +P V LP L+L+ G+ G R ++ +
Sbjct: 167 EYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEI 226
Query: 385 VYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSV--------MR 436
VY +V+V+ + QR +LGHTD V LA+ +A+ Q +R
Sbjct: 227 VYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVR 286
Query: 437 LWD---FQTGRCLCLFRSPMHVVC-SLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLG 492
+WD T + + L V C S +DSG LC + D M+ W + G
Sbjct: 287 VWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVI--DDSNEHMLTVWDWQKKAKG 344
Query: 493 GEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQ 552
E+ T+ V A D + +CG+ + W G L G++ +
Sbjct: 345 AEIKT-----TNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPK 399
Query: 553 FTD-LAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQK 611
F LAF D S ++ + S++ P + P G +
Sbjct: 400 FVQCLAFLGNGDVLTGDSGGVMLIWSKT---------------TVEPTPGKGPKGVYQIS 444
Query: 612 QTFSSGPGIAISSLSVSPAMCAV-GSEDGFLRLWPLDFSSVLLEAEHEGP--VSSVCVSP 668
+ + G + + M G +D + LW D + E E E P ++
Sbjct: 445 KQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNP---EREIEVPDQYGTIRAVA 501
Query: 669 DGL--RVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRI 726
+G + L TS + T + + + + HT + LA + L T +QDR V +
Sbjct: 502 EGKADQFLVGTSRNFI-LRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCL 560
Query: 727 WDLATLQQLYDFTSSEDAP--CAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHR 784
W+ +++ ++T D P CA FHP+ G SG E +++ HT
Sbjct: 561 WN--SMEHRLEWTRLVDEPGHCA-DFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGN 617
Query: 785 GAVTGLTATPDGRLL 799
++ + + DG L
Sbjct: 618 EQLSVMRYSIDGTFL 632
Score = 43.1 bits (100), Expect = 0.002
Identities = 80/381 (20%), Positives = 140/381 (36%), Gaps = 46/381 (12%)
Query: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
L+L+ GY G RAN+ P TG Y +VV+ + Q+H+ GH+ + LA+
Sbjct: 201 LKLEWAYGYRGKDCRANVYLLP-TGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAI 259
Query: 1167 SHSAQVLASAS----GRSSTTAHCQIRVWD-VSGGLCQHL---IFPHSTTVLALAFSPDD 1218
+A+ + +RVWD V+ Q + F L + +
Sbjct: 260 HPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSG 319
Query: 1219 RLLVTLGDHDGRTLALWG---TATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTF 1275
L + D + L +W A + +T E V V F+P DA + G+ + F
Sbjct: 320 VHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTN--EVVLAVEFHPTDANTIITCGKSHIFF 377
Query: 1276 WLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRA----- 1330
W SL ++ + + L + + G S G + +W
Sbjct: 378 WTWSGN----SLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTP 433
Query: 1331 -----GRCFLSWE--ADDGGIGLL--LFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGA 1381
G +S + A DG + L + +G L G ++ LW E
Sbjct: 434 GKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPE-------- 485
Query: 1382 SSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEV 1441
E E+ + A + D +VGT+ + ++ +G + GH ++ +
Sbjct: 486 ----REIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIE-VQGHTDELWGL 540
Query: 1442 VFSPGESHCATCSEDGSVRVW 1462
P + TC++D V +W
Sbjct: 541 ATHPFKDLLLTCAQDRQVCLW 561
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 72.4 bits (176), Expect = 4e-12
Identities = 105/466 (22%), Positives = 177/466 (37%), Gaps = 49/466 (10%)
Query: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413
LP L+L+ G+ G R ++ +VY +V+V+ + QR +LGHTD V
Sbjct: 254 LPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVK 313
Query: 414 ALALDGSSSLLASAQARAPSV--------MRLWD---FQTGRCLCLFRSPMHVVC-SLSF 461
LA+ +A+ Q +R+WD T + + L V C S
Sbjct: 314 CLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSK 373
Query: 462 SDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMA 521
+DSG LC + D M+ W + G E+ T+ V A D +
Sbjct: 374 ADSGVHLCVI--DDSNEHMLTVWDWQKKAKGAEIKT-----TNEVVLAVEFHPTDANTII 426
Query: 522 SCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTD-LAFKQARDGCPEPSAAMLFVCSRSG 580
+CG+ + W G L G++ +F LAF D S ++ + S++
Sbjct: 427 TCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKT- 485
Query: 581 HILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAV-GSEDG 639
P + P G + + + G + + M G +D
Sbjct: 486 --------------TVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDR 531
Query: 640 FLRLWPLDFSSVLLEAEHEGP--VSSVCVSPDGL--RVLSATSSGHLGFLDTLSRVYHML 695
+ LW D + E E E P ++ +G + L TS + T + + +
Sbjct: 532 KIILWDHDLNP---EREIEVPDQYGTIRAVAEGKADQFLVGTSRNFI-LRGTFNDGFQIE 587
Query: 696 ARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAP--CAVTFHPT 753
+ HT + LA + L T +QDR V +W+ +++ ++T D P CA FHP+
Sbjct: 588 VQGHTDELWGLATHPFKDLLLTCAQDRQVCLWN--SMEHRLEWTRLVDEPGHCA-DFHPS 644
Query: 754 RPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLL 799
G SG E +++ HT ++ + + DG L
Sbjct: 645 GTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFL 690
Score = 43.1 bits (100), Expect = 0.002
Identities = 80/381 (20%), Positives = 140/381 (36%), Gaps = 46/381 (12%)
Query: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
L+L+ GY G RAN+ P TG Y +VV+ + Q+H+ GH+ + LA+
Sbjct: 259 LKLEWAYGYRGKDCRANVYLLP-TGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAI 317
Query: 1167 SHSAQVLASAS----GRSSTTAHCQIRVWD-VSGGLCQHL---IFPHSTTVLALAFSPDD 1218
+A+ + +RVWD V+ Q + F L + +
Sbjct: 318 HPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSG 377
Query: 1219 RLLVTLGDHDGRTLALWG---TATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTF 1275
L + D + L +W A + +T E V V F+P DA + G+ + F
Sbjct: 378 VHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTN--EVVLAVEFHPTDANTIITCGKSHIFF 435
Query: 1276 WLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRA----- 1330
W SL ++ + + L + + G S G + +W
Sbjct: 436 WTWSGN----SLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTP 491
Query: 1331 -----GRCFLSWE--ADDGGIGLL--LFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGA 1381
G +S + A DG + L + +G L G ++ LW E
Sbjct: 492 GKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPE-------- 543
Query: 1382 SSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEV 1441
E E+ + A + D +VGT+ + ++ +G + GH ++ +
Sbjct: 544 ----REIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIE-VQGHTDELWGL 598
Query: 1442 VFSPGESHCATCSEDGSVRVW 1462
P + TC++D V +W
Sbjct: 599 ATHPFKDLLLTCAQDRQVCLW 619
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 69.3 bits (168), Expect = 3e-11
Identities = 87/347 (25%), Positives = 137/347 (39%), Gaps = 47/347 (13%)
Query: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLG-FLDTLSRVYHMLARSHTAPVLALAMEQR 711
LE E + +++ +SPD +++A+ + L + V + HTAPV +A +
Sbjct: 61 LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPT 120
Query: 712 RGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFH--PTRPTFFCGFSSGAVRSF 769
LAT D VR+WD+ + F S V FH PTR F + A+R +
Sbjct: 121 STLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVW 180
Query: 770 SLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSS-----CSQGSLAQYSCADPQWHVLRVA 824
SL+ L T H AVT L + DG + SS C L V
Sbjct: 181 SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVE 240
Query: 825 ADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTL---DLAS 881
A ++ P+ P S L V G G D GTL + AS
Sbjct: 241 AAVLLPEEPV--SQLGVKSPGLYFLTAG--------------------DQGTLRVWEAAS 278
Query: 882 SRLDSAMAVCFGPA----------ALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPC 931
+ A GP G +L +T+ + +++ +A S R+ ++ G E
Sbjct: 279 GQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338
Query: 932 PSLTLS-EDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPVQAV 977
L ED+ ++ + +KV++ T A Q+ GH++ V A+
Sbjct: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC---QILHGHTDIVLAL 382
Score = 64.3 bits (155), Expect = 1e-09
Identities = 60/212 (28%), Positives = 96/212 (45%), Gaps = 15/212 (7%)
Query: 1400 SFDDSVDMGVVGTTAGTLWFVSWA--EGTSTRLISG-HRSKVNEVVFSPGESHCATCSED 1456
+FD S D V+ T + L WA EG+ TRL H + V + F P + AT D
Sbjct: 71 AFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTAPVATMAFDPTSTLLATGGCD 130
Query: 1457 GSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTA 1516
G+VRVW + F+ +A+ P P + L + D ++R++S+ +
Sbjct: 131 GAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPD----PTRLLLFSSATDAAIRVWSLQDRS 186
Query: 1517 MELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV--SHPCTGT-TFRVLSDHQGAPIST 1573
+ H A+T++AFS DG T+LS +D + + C T T V + A
Sbjct: 187 CLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAA---- 242
Query: 1574 ICVTCKECEDLGVEGTDLWLAASGDQ-RVSVW 1604
+ + + LGV+ L+ +GDQ + VW
Sbjct: 243 VLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVW 274
Score = 57.8 bits (138), Expect = 9e-08
Identities = 42/171 (24%), Positives = 73/171 (42%), Gaps = 16/171 (9%)
Query: 1434 HRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRP 1493
H +N V +P + AT S+D + ++WAL +L+ F + C+ +S P
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFS------P 531
Query: 1494 EQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSH 1553
Q LA DG+++++++ + H ++ VAF + G +LS DGLV +
Sbjct: 532 MDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWT 591
Query: 1554 PCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVW 1604
R L H+ + C +D + G + D RV +W
Sbjct: 592 IKNNECVRTLDAHED---KVWGLHCSRLDDHALTG-------ASDSRVILW 632
Score = 45.1 bits (105), Expect = 6e-04
Identities = 91/429 (21%), Positives = 165/429 (38%), Gaps = 75/429 (17%)
Query: 1157 HSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSP 1216
H+A ++T+A ++ +LA+ + +RVWD+ H V +AF P
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGA------VRVWDIVRHYGTHHFRGSPGVVHLVAFHP 161
Query: 1217 DDRLLVTLGDHDGRTLALWG----------TATYDLVSSTRLPEPVHGVAFNPWDAGELT 1266
D L+ + +W TA Y V+S H + + D
Sbjct: 162 DPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDK---I 218
Query: 1267 CVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGEL------TSLCYGAPPLLY-CGTS 1319
C+ W LQ A R PV E+V A L + L +P L +
Sbjct: 219 CI------IWDLQSCQA-----TRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGD 267
Query: 1320 SGQVCVWDTRAGRCFLSWEADDGGIG------LLLFSGSRLVSGSSTGRLRLWAVGAVSE 1373
G + VW+ +G+C + +A G G L + +++ ++ L L+ ++
Sbjct: 268 QGTLRVWEAASGQCVYT-QAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSL-R 325
Query: 1374 LRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISG 1433
L+ + +G S E VLD F D VV + V + ++ +++ G
Sbjct: 326 LQKQFAGYS------EEVLD-----VRFLGPEDSHVVVASNSPCLKVFELQTSACQILHG 374
Query: 1434 HRSKVNEV-VFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGR 1492
H V + VF G A+C++D SVR+W + V+ V S + CC R
Sbjct: 375 HTDIVLALDVFRKGWLF-ASCAKDQSVRIWRMNKAGQVM--CVAQGSGHTHSVGTVCCSR 431
Query: 1493 PEQQRLAAGYGDGSLRIFSVSRTAMELKMHP---------------HPVALTTVAFSTDG 1537
++ L G D +++++ + + + P H + +VA + +
Sbjct: 432 LKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND 491
Query: 1538 QTVLSGDKD 1546
+ + +G +D
Sbjct: 492 KLLATGSQD 500
Score = 45.1 bits (105), Expect = 6e-04
Identities = 87/454 (19%), Positives = 148/454 (32%), Gaps = 67/454 (14%)
Query: 405 FLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDS 464
F G V +A + L + + +R+W Q CL + + V SL+FS
Sbjct: 147 FRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSAD 206
Query: 465 GALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCG 524
G + G+D + + W V V E ++ G
Sbjct: 207 GHTMLSSGRDK----ICIIWDLQSCQATRTVPVFESVEA--------AVLLPEEPVSQLG 254
Query: 525 QGSVRLWRLRGG---VLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGH 581
S L+ L G LR G+ Q Q C A + + + + H
Sbjct: 255 VKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADH 314
Query: 582 IL------EIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVG 635
L + Q+ ++ +L R G S+ P + + L S G
Sbjct: 315 NLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHG 374
Query: 636 --------------------SEDGFLRLWPLDFSSVLL----EAEHEGPVSSVCVS---- 667
++D +R+W ++ + ++ + H V +VC S
Sbjct: 375 HTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKE 434
Query: 668 ---------------PDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
P +LS ++ G + ++ R H + ++A+
Sbjct: 435 SFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQ---RCHDKDINSVAIAPND 491
Query: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLE 772
LAT SQDRT ++W L Q L F+ V F P + G ++ ++L+
Sbjct: 492 KLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ 551
Query: 773 AAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQG 806
L H +V + G L SS S G
Sbjct: 552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDG 585
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/173 (23%), Positives = 71/173 (41%), Gaps = 18/173 (10%)
Query: 635 GSEDGFLRLWPL-----------DFSSVLLEAE-----HEGPVSSVCVSPDGLRVLSATS 678
GS+D ++LWPL D +LL+A+ H+ ++SV ++P+ ++L+ S
Sbjct: 440 GSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND-KLLATGS 498
Query: 679 SGHLGFLDTLSRVYHM-LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYD 737
L L + + + H + + LAT S D T+++W L L
Sbjct: 499 QDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Query: 738 FTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGL 790
F + + V F S G V+ ++++ E + H V GL
Sbjct: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGL 611
Score = 40.8 bits (94), Expect = 0.012
Identities = 49/230 (21%), Positives = 82/230 (35%), Gaps = 33/230 (14%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFP---------- 1204
SGH+ + T+ S + + C +++W + L P
Sbjct: 418 SGHTHSVGTVCCSRLKESFLVTGSQD-----CTVKLWPLPKALLSKNTAPDNGPILLQAQ 472
Query: 1205 -----HSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSS-TRLPEPVHGVAFN 1258
H + ++A +P+D+LL T G D RT LW L+ + + V F+
Sbjct: 473 TTQRCHDKDINSVAIAPNDKLLAT-GSQD-RTAKLWALPQCQLLGVFSGHRRGLWCVQFS 530
Query: 1259 PWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGT 1318
P D T GT+ W LQ + + V + T L
Sbjct: 531 PMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSG-------- 582
Query: 1319 SSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLW 1366
S G V +W + C + +A + + L S ++G+S R+ LW
Sbjct: 583 SDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 38.1 bits (87), Expect = 0.076
Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 6/120 (5%)
Query: 1430 LISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPC 1489
+ SGHR + V FSP + AT S DG++++WAL + F+ + S L +A+
Sbjct: 516 VFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV--- 572
Query: 1490 CGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLV 1549
+L + DG ++++++ + H + + S L+G D V
Sbjct: 573 ---SRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRV 629
Score = 33.5 bits (75), Expect = 1.9
Identities = 80/353 (22%), Positives = 125/353 (35%), Gaps = 19/353 (5%)
Query: 658 EGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALA---MEQRRGQ 714
E PVS + V GL L+A G L + S P L + G
Sbjct: 247 EEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGV 306
Query: 715 LATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF-HPTRPTFFCGFSSGAVRSFSLEA 773
+ T + D + +++ +L+ F + V F P +S ++ F L+
Sbjct: 307 VLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQT 366
Query: 774 AEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAP 833
+ + H H V L G LF+SC++ + + V+ VA
Sbjct: 367 SACQILHG-HTDIVLALDVFRKG-WLFASCAKDQSVRIWRMNKAGQVMCVAQGS---GHT 421
Query: 834 ASPSALAVSRDGRLLAFVGPSRCTVTV--MGSASLDELLRVDIGTLDLASSRLDSAMAVC 891
S + SR G CTV + + A L + D G + L +
Sbjct: 422 HSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD 481
Query: 892 FGPAALG---HLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIA-A 947
A+ LL + S +R L A+ + + H + S + L A A
Sbjct: 482 INSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASA 541
Query: 948 GRTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQVLSAGD--AVFLWDV 998
TIK+W A Q + + GH V VAF Q+LS+G V LW +
Sbjct: 542 DGTIKLW--ALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
Score = 32.3 bits (72), Expect = 4.2
Identities = 30/127 (23%), Positives = 49/127 (38%), Gaps = 2/127 (1%)
Query: 619 GIAISSLSVSPAMCAVGSEDGFLRLWPL-DFSSVLLEAEHEGPVSSVCVSPDGLRVLSAT 677
G+ S + A S DG ++LW L DFS + H+ V V G ++LS+
Sbjct: 523 GLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSG 582
Query: 678 SSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIW-DLATLQQLY 736
S G + + +H V L + T + D V +W D+ +Q
Sbjct: 583 SDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAE 642
Query: 737 DFTSSED 743
+ E+
Sbjct: 643 EQARQEE 649
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 68.9 bits (167), Expect = 4e-11
Identities = 50/188 (26%), Positives = 79/188 (42%), Gaps = 2/188 (1%)
Query: 625 LSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSGHLG 683
L+ + GS+ G +R+W L+ + +L H+ + S+ P G V S + ++
Sbjct: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
Query: 684 FLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSED 743
D + R H+ V L LA+ + D TV++WDL + + +F
Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
Query: 744 APCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSC 803
V FHP G S +R + LE +V+ G V + PDG L+S C
Sbjct: 191 PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGC 250
Query: 804 SQGSLAQY 811
Q SL Y
Sbjct: 251 -QDSLRVY 257
Score = 53.5 bits (127), Expect = 2e-06
Identities = 89/443 (20%), Positives = 164/443 (37%), Gaps = 32/443 (7%)
Query: 622 ISSLSVSPA---MCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSAT 677
+SSL + A + A G +D + LW ++ + ++ H PV SV ++ +++ +
Sbjct: 23 VSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS 82
Query: 678 SSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYD 737
SG + D + H A + +L +A+ SQD +++WD+ ++
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 738 FTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGR 797
+ A + F P V+ + L A +++ E H G V + P+
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Query: 798 LLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCT 857
LL S S ++ W + + P ++ + DG L
Sbjct: 203 LLASGSSDRTIR-------FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLR 255
Query: 858 VTVMGSASLDELLRVDIGTL-DLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVS 916
V +++ V+ G + DLA D + V F + + +V + RV V+
Sbjct: 256 VYGWEPERCFDVVLVNWGKVADLAICN-DQLIGVAFSQSNVSSYVVDLT--RVTRTGTVA 312
Query: 917 GRIIRE-LPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPV- 974
+++ P P P PS L ++++ + PQ +SE
Sbjct: 313 RDPVQDHRPLAQPLPNPSAPLR--------------RIYERPSTTCSKPQRVKQNSESER 358
Query: 975 QAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASEL 1034
++ + D+ + S + D + S PP ++ P P ED A+ A E
Sbjct: 359 RSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPR-RSEPFPAPPEDDAATAKEA 417
Query: 1035 PRQQVPKPCQASPPRLGVCARPP 1057
+ Q P L V RPP
Sbjct: 418 AKPSPAMDVQFPVPNLEVLPRPP 440
Score = 50.1 bits (118), Expect = 2e-05
Identities = 55/253 (21%), Positives = 104/253 (41%), Gaps = 22/253 (8%)
Query: 1300 AGELTSLCYGAPP--LLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSR--LV 1355
A ++SL G LL G +V +W C +S + + + +V
Sbjct: 20 ASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIV 79
Query: 1356 SGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAG 1415
+GS +G +R+W + A LR +++ V S S D ++
Sbjct: 80 AGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK--------- 130
Query: 1416 TLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQV 1475
LW + +G R GH V + FSP A+ ++D +V++W L + +++ +F
Sbjct: 131 -LWDIR-RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
Query: 1476 LNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFST 1535
+ + P + LA+G D ++R + + + + + P + +V F+
Sbjct: 188 HTGPVNVVEF------HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
Query: 1536 DGQTVLSGDKDGL 1548
DG + SG +D L
Sbjct: 242 DGCCLYSGCQDSL 254
Score = 45.8 bits (107), Expect = 4e-04
Identities = 41/155 (26%), Positives = 65/155 (41%), Gaps = 26/155 (16%)
Query: 1141 VVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLAS---------ASGRSSTTAHCQIRVW 1191
++V SG+ + W +A+I + H A + + ASG T I++W
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTN----IKLW 132
Query: 1192 DVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPE- 1250
D+ C HS V L FSPD + L + D T+ LW DL + + E
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAA--DDHTVKLW-----DLTAGKMMSEF 185
Query: 1251 -----PVHGVAFNPWDAGELTCVGQGTVTFWLLQQ 1280
PV+ V F+P + + T+ FW L++
Sbjct: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/144 (22%), Positives = 61/144 (42%), Gaps = 7/144 (4%)
Query: 1431 ISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCC 1490
++GH S V V + E S+ GS+RVW L + +++ + L +
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDF----- 113
Query: 1491 GRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVA 1550
P + +A+G D +++++ + R + H A+ + FS DG+ + S D V
Sbjct: 114 -HPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
Query: 1551 VSHPCTGTTFRVLSDHQGAPISTI 1574
+ G H G P++ +
Sbjct: 173 LWDLTAGKMMSEFPGHTG-PVNVV 195
Score = 39.7 bits (91), Expect = 0.026
Identities = 47/227 (20%), Positives = 90/227 (39%), Gaps = 25/227 (11%)
Query: 1160 EISTLALSHSAQVLASASGRSSTTA--HCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPD 1217
EI A + S+ VL ASGR T C++ +W ++ C + H++ V ++ +
Sbjct: 15 EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTP 74
Query: 1218 DRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEP-VHGVAFNPWDAGELTCVG--QGTVT 1274
+ L+V G G ++ +W ++ + + + + F+P+ GE G +
Sbjct: 75 EELIVA-GSQSG-SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIK 130
Query: 1275 FWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPP---LLYCGTSSGQVCVWDTRAG 1331
W ++++G + + V C P L V +WD AG
Sbjct: 131 LWDIRRKGCVFRYRGHSQAV-----------RCLRFSPDGKWLASAADDHTVKLWDLTAG 179
Query: 1332 RCFLSWEADDGGIGLLLFSGSR--LVSGSSTGRLRLWAVGAVSELRC 1376
+ + G + ++ F + L SGSS +R W + + C
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC 226
Score = 34.7 bits (78), Expect = 0.84
Identities = 33/153 (21%), Positives = 61/153 (39%), Gaps = 17/153 (11%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GHT V ++ L+ L+ + +R+WD + + L +CSL F G
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGS--IRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 467 LLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQG 526
+ +D T + W + G V + H+ V+ R + + ++
Sbjct: 119 FVASGSQD----TNIKLWDIRRKG----CVFRYRGHSQ-AVRCLRFSPDGKWLASAADDH 169
Query: 527 SVRLWRLRGGVLRS------CPVDLGEHHALQF 553
+V+LW L G + S PV++ E H ++
Sbjct: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Score = 32.0 bits (71), Expect = 5.4
Identities = 19/73 (26%), Positives = 29/73 (39%), Gaps = 2/73 (2%)
Query: 403 RFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFS 462
R +GH + +L +AS + ++LWD + C+ +R V L FS
Sbjct: 99 RTLMGHKANICSLDFHPYGEFVASGSQ--DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFS 156
Query: 463 DSGALLCGVGKDH 475
G L DH
Sbjct: 157 PDGKWLASAADDH 169
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 68.6 bits (166), Expect = 5e-11
Identities = 77/290 (26%), Positives = 113/290 (38%), Gaps = 30/290 (10%)
Query: 1282 GADISLQVRREPVPEAVGAGELTSLCYGAP-PLLYCGTSSGQVCVWDTRAGRCFLSWEAD 1340
G +L VRR G GE+ S + +L G+ G V W+TR+G+
Sbjct: 4 GVPATLAVRRVKFFGQHG-GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGH 62
Query: 1341 DGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVS 1398
G + FS G S S +RLW V LR SV + S
Sbjct: 63 TGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLAS 122
Query: 1399 ASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGS 1458
+D V LW V G RL+ GHR + FSP + AT S D +
Sbjct: 123 GGWDKRV----------MLWDVQ--SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDST 170
Query: 1459 VRVWALASMELVIQFQVL-----NQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVS 1513
V +W L + + Q L N SCLC + S LA+G D ++ I+ +
Sbjct: 171 VHIWDLRMVTPAVSHQALEGHSANISCLCYSAS---------GLLASGSWDKTIHIWKPT 221
Query: 1514 RTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVL 1563
+++ +++ H + ++AFS D + S +V V TG L
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
Score = 54.3 bits (129), Expect = 1e-06
Identities = 51/223 (22%), Positives = 86/223 (38%), Gaps = 35/223 (15%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFS 1215
GH+ + S + ASAS C +R+WDV+ C ++ H +V ++FS
Sbjct: 61 GHTGPVKFCRFSPDGHLFASAS------CDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
Query: 1216 PDDRLLVTLGDHDGRTLALWGTAT----------YDLVSSTRLPEPVHGVAFNPWDAGEL 1265
PD R L + G D R + LW + D + S+ V+ +A WD+
Sbjct: 115 PDSRQLAS-GGWDKRVM-LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDS--- 169
Query: 1266 TCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCV 1325
TV W L+ +S Q + ++ LCY A LL G+ + +
Sbjct: 170 ------TVHIWDLRMVTPAVSHQALEG------HSANISCLCYSASGLLASGSWDKTIHI 217
Query: 1326 WDTRAGRCFLSWEADDGGIGLLLFSGSR--LVSGSSTGRLRLW 1366
W + + + + FS L S + +++W
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 48.9 bits (115), Expect = 4e-05
Identities = 43/170 (25%), Positives = 61/170 (35%), Gaps = 1/170 (0%)
Query: 617 GPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLE-AEHEGPVSSVCVSPDGLRVLS 675
G + S+ S M GSEDG + W +L H GPV SPDG S
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFAS 80
Query: 676 ATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQL 735
A+ + D + + H V ++ QLA+ D+ V +WD+ + Q L
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 736 YDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRG 785
D+ + F PT G V + L V H G
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Score = 45.4 bits (106), Expect = 5e-04
Identities = 35/139 (25%), Positives = 58/139 (41%)
Query: 656 EHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQL 715
+H G V+S SPDG +L+ + G + +T S HT PV
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 716 ATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAE 775
A+ S D TVR+WD+A + L + + V+F P G V + +++ +
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 776 VLVEHTCHRGAVTGLTATP 794
+L HR ++ +P
Sbjct: 139 MLRLLVGHRDSIQSSDFSP 157
Score = 43.9 bits (102), Expect = 0.001
Identities = 33/102 (32%), Positives = 47/102 (46%), Gaps = 6/102 (5%)
Query: 900 LLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDAR-FLLIAAGRTIKVWDYAT 958
LL + V + SG+++ L G H P S D F + T+++WD A
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLGG-HTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR 94
Query: 959 QASPGPQVYIGHSEPVQAVAFSPDQQQVLSAG--DAVFLWDV 998
+V GH V+ V+FSPD +Q+ S G V LWDV
Sbjct: 95 AKCL--RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Score = 43.1 bits (100), Expect = 0.002
Identities = 63/253 (24%), Positives = 96/253 (37%), Gaps = 25/253 (9%)
Query: 750 FHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLA 809
F P G G V + + ++L H G V +PDG L S A
Sbjct: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFAS-------A 81
Query: 810 QYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDEL 869
C W V R V S ++ S D R LA G + + + ++
Sbjct: 82 SCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM--LWDVQSGQM 139
Query: 870 LRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPE 929
LR+ +G D S S C + S+ + L V+ + + H
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWD------STVHIWDLRMVTPAVSHQALEGHSA 193
Query: 930 PCPSLTLSEDARFLLIAAG---RTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQV 986
L S L+A+G +TI +W T +S Q+ GH V+++AFSPD+ +
Sbjct: 194 NISCLCYSASG---LLASGSWDKTIHIWK-PTTSSLLIQLK-GHVTWVKSIAFSPDELWL 248
Query: 987 LSAGDA--VFLWD 997
SAG + V +WD
Sbjct: 249 ASAGYSRMVKVWD 261
Score = 35.0 bits (79), Expect = 0.64
Identities = 43/180 (23%), Positives = 66/180 (36%), Gaps = 15/180 (8%)
Query: 359 LRLKGVIGFGGHG--TRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFL--GHTDKVSA 414
L ++ V FG HG + ++PDG ++ V Q + GHT V
Sbjct: 9 LAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKF 68
Query: 415 LALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKD 474
L ASA +RLWD +CL + + V ++SFS L G D
Sbjct: 69 CRFSPDGHLFASASCDC--TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
Query: 475 HHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLR 534
V+ W G+++ L H D +Q+ + +V +W LR
Sbjct: 127 KR----VMLWDV----QSGQMLRLLVGHRD-SIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
Score = 33.9 bits (76), Expect = 1.4
Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Query: 1685 SPGTHLLAVGFAECMLRLVDCAMGTA-QDFAGHDNAVHLCRFTPSARLLFTAARNE-ILV 1742
SP HL A +C +RL D A + GH +V F+P +R L + ++ +++
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131
Query: 1743 WEV 1745
W+V
Sbjct: 132 WDV 134
Score = 33.9 bits (76), Expect = 1.4
Identities = 36/156 (23%), Positives = 56/156 (35%), Gaps = 7/156 (4%)
Query: 621 AISSLSVSPAM--CAVGSEDGFLRLWPLDFSSVLLEAE----HEGPVSSVCVSPDGLRVL 674
+I S SP + A GS D + +W L + + + H +S +C S GL
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208
Query: 675 SATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQ 734
+ + T S + L + H V ++A LA+ R V++WD T +
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQL-KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
Query: 735 LYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFS 770
L D F P G + R S
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
Score = 33.5 bits (75), Expect = 1.9
Identities = 20/72 (27%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GH V ++A LASA ++++WD TG+CL + + V + +F+ G
Sbjct: 231 GHVTWVKSIAFSPDELWLASAGYSR--MVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK 288
Query: 467 LLCGVGKDHHGR 478
+L D R
Sbjct: 289 ILVSGAADQTRR 300
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 63.9 bits (154), Expect = 1e-09
Identities = 165/717 (23%), Positives = 255/717 (35%), Gaps = 109/717 (15%)
Query: 355 PDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGE-------QRFFLG 407
P L L V G+ G +R L+ VVY V+V+ G QR + G
Sbjct: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
Query: 408 HTDKVSALALDGSSSLLASAQARAPS--------VMRLWDFQTGRCLCLFRSPMHV---- 455
HTD V LA+ +AS Q V+ +WD +T L L +
Sbjct: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSET--LLKLQEIGLGAFERG 361
Query: 456 VCSLSFS--DSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVT 513
V +L+FS D GA LC V D M+ W + G + K+ D V A
Sbjct: 362 VGALAFSAADQGAFLCVV--DDSNEHMLSVWDCSR----GMKLAEIKSTND-SVLAVGFN 414
Query: 514 FFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDG-CPEPSAAM 572
D + + + G+ V W GGV P + L KQ G +P
Sbjct: 415 PRDSSCIVTSGKSHVHFWNWSGGV--GVPGN---------GTLTRKQGVFGKYKKPKFIP 463
Query: 573 LFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQK------QTFSSGPGIAISSLS 626
FV G IL D + ++ R ++TPG ++ Q + I L
Sbjct: 464 CFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR 523
Query: 627 VSPAMCAVGSEDGFLRLWPLDFSSVLLEAE---HEGPVSSVCVSPDGLRVLSATSSGHLG 683
+ + G D L W + L EAE H G V ++ G +L T+ L
Sbjct: 524 RDGTVLSGGGRDRRLVQWGPGLVA-LQEAEIPEHFGAVRAIAEGL-GSELLVGTTKNAL- 580
Query: 684 FLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSED 743
L++ + + + HT + L + + T DR + +WD + + E
Sbjct: 581 LRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKET 640
Query: 744 APCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSC 803
CA FHP+ G ++G E E++ + ++ + +PDG L
Sbjct: 641 GLCA-DFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGS 699
Query: 804 SQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGS 863
+ YS + R C + + L S+DG +M +
Sbjct: 700 HDNVIYIYSVSSDGAKSSRFGR---CMGHSSFITHLDWSKDGNF------------IMSN 744
Query: 864 ASLDELLRVDI-GTLDLASSRLDS-----AMAVCFGPAALGHLLVSTSSNRVVVLDAVSG 917
+ E+L D+ G +R +S A C LG + V D G
Sbjct: 745 SGDYEILYWDVAGGCKQLKNRYESRDREWATYTC----VLGFHVYG------VWPDGSDG 794
Query: 918 RIIRELPGVHPEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQASPGP-QVYIGHSEPVQ 975
I SL S + R + +A + ++ Y + P ++Y GH V
Sbjct: 795 TDIN-----------SLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVT 843
Query: 976 AVAFSPDQQQVLSAGD---AVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAAS 1029
+V F+ D ++S G ++F W VL GA PA T L A+S
Sbjct: 844 SVRFTHDDSHLVSLGGKDASIFQWRVLGA-------GGAGPAPATPSRTPSLSPASS 893
Score = 55.8 bits (133), Expect = 4e-07
Identities = 161/756 (21%), Positives = 250/756 (33%), Gaps = 136/756 (17%)
Query: 865 SLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELP 924
SL + LRV ++L + L A+ + L V SS + A G + P
Sbjct: 18 SLSQRLRVQEQEMELVKAALAEALRLL-------RLQVPPSSLQGSGTPAPPGDSLAAPP 70
Query: 925 GVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQ 984
G+ P PSL ++ G + + ++SPGP Q + P
Sbjct: 71 GLPPTCTPSL----------VSRGTQTET-EVELKSSPGPPGLSNGPPAPQGASEEPSGT 119
Query: 985 QVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQ 1044
Q S G +P P PP P ++S SE PRQ++ +
Sbjct: 120 Q--SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRN--SSSSSSPSERPRQKLSRKAI 175
Query: 1045 ASPPRL----------GVCARPPEGGDGARDTRNS-----------GAPRTTYLASCKAF 1083
+S L G GG G+R + + G P T Y+
Sbjct: 176 SSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYI------ 229
Query: 1084 TPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVV 1143
P+ + G PPP + L L V GY G + ++ +G Y +VV+
Sbjct: 230 -PSGIRSLEELPSG--PPPET---LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVL 283
Query: 1144 E-------DLHSGAQQHWSGHSAEISTLALSHSAQVLASAS----GRSSTTAHCQIRVWD 1192
G Q+H+ GH+ + LA+ +AS + + +WD
Sbjct: 284 YRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWD 343
Query: 1193 VSGGLCQHLI----FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTAT-YDLVSSTR 1247
L I F LA + + L + D + L++W + L
Sbjct: 344 SETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKS 403
Query: 1248 LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSL- 1306
+ V V FNP D+ + G+ V FW G + G G LT
Sbjct: 404 TNDSVLAVGFNPRDSSCIVTSGKSHVHFW-NWSGGVGVP------------GNGTLTRKQ 450
Query: 1307 ----CYGAPPLLYC-----------GTSSGQVCVW-----DTRA-GR--------CFLSW 1337
Y P + C G S G + W D++ GR
Sbjct: 451 GVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQA 510
Query: 1338 EADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGA 1395
A +G I L G+ L G RL W G V+ E E+
Sbjct: 511 HAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVA------------LQEAEIPEHFG 558
Query: 1396 VVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE 1455
V A + +VGTT L A+G S +I GH ++ + P ++ TC
Sbjct: 559 AVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGH 617
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRT 1515
D + +W S L L ++ LC + P +A G G +
Sbjct: 618 DRQLCLWDGESHALAWSID-LKETGLCADF------HPSGAVVAVGLNTGRWLVLDTETR 670
Query: 1516 AMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
+ + L+ V +S DG + G D ++ +
Sbjct: 671 EIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYI 706
>gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo
sapiens]
Length = 542
Score = 62.0 bits (149), Expect = 5e-09
Identities = 58/267 (21%), Positives = 108/267 (40%), Gaps = 44/267 (16%)
Query: 1317 GTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRC 1376
G + +WD + C G + L + +V+GSS +R+W V
Sbjct: 256 GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNT------ 309
Query: 1377 KGSGASSVFMEHELVL-----DGAVVSASFDDSVDMGVVGTTAGTLW-FVSWAEGTSTRL 1430
G +++ +E VL +G +V+ S D S+ +W S + T R+
Sbjct: 310 -GEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI----------AVWDMASATDITLRRV 358
Query: 1431 ISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCC 1490
+ GHR+ VN V F + + + S D +++VW+ ++ E V + CL +
Sbjct: 359 LVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY----- 411
Query: 1491 GRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVA 1550
+ + +G D ++R++ + A + H + + F D + ++SG DG +
Sbjct: 412 ---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIK 466
Query: 1551 V---------SHPCTGTTFRVLSDHQG 1568
V P + R L +H G
Sbjct: 467 VWDLQAALDPRAPASTLCLRTLVEHSG 493
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/261 (24%), Positives = 113/261 (43%), Gaps = 33/261 (12%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
+GH+ S L L + +V+ + S S+ +RVWDV+ G + + H+ VL L F
Sbjct: 277 TGHTG--SVLCLQYDERVIVTGSSDST------VRVWDVNTGEVLNTLIHHNEAVLHLRF 328
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGE---LTCVGQG 1271
S + L+VT R++A+W A+ ++ R+ H A N D + ++ G
Sbjct: 329 S--NGLMVTCSKD--RSIAVWDMASATDITLRRVLVG-HRAAVNVVDFDDKYIVSASGDR 383
Query: 1272 TVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAG 1331
T+ W +L + + L Y L+ G+S + +WD G
Sbjct: 384 TIKVWSTSTCEFVRTLNGHKRGI---------ACLQY-RDRLVVSGSSDNTIRLWDIECG 433
Query: 1332 RCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG-ASSVFMEH-- 1388
C E + + + F R+VSG+ G++++W + A + R S +EH
Sbjct: 434 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 493
Query: 1389 ---ELVLDG-AVVSASFDDSV 1405
L D ++S+S DD++
Sbjct: 494 RVFRLQFDEFQIISSSHDDTI 514
Score = 38.1 bits (87), Expect = 0.076
Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 25/166 (15%)
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRT 1515
D S+++W S+E + S LCL + +++ + G D ++R++ V+
Sbjct: 259 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTG 310
Query: 1516 AMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFR-VLSDHQGAPISTI 1574
+ + H A+ + FS S D+ V T T R VL H+ A
Sbjct: 311 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA----- 365
Query: 1575 CVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS 1620
V + +D + ++ASGD+ + VW++ + CE V L+
Sbjct: 366 -VNVVDFDDKYI------VSASGDRTIKVWST----STCEFVRTLN 400
Score = 36.2 bits (82), Expect = 0.29
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
++ E C+ D +++S + D S + HT VL L ++R
Sbjct: 233 IQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER- 291
Query: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
+ T S D TVR+WD+ T + L +A + F
Sbjct: 292 -VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF 328
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 14/117 (11%)
Query: 622 ISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSG 680
I+ L + GS D +RLW ++ + L E HE V C+ D R++S G
Sbjct: 406 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDG 463
Query: 681 HL------GFLDTLSRVYHMLARS---HTAPVLALAMEQRRGQLATVSQDRTVRIWD 728
+ LD + + R+ H+ V L ++ Q+ + S D T+ IWD
Sbjct: 464 KIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 518
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 62.0 bits (149), Expect = 5e-09
Identities = 69/280 (24%), Positives = 114/280 (40%), Gaps = 46/280 (16%)
Query: 1342 GGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRC----KGSGASSVFMEHELVLDGA 1395
GGI L S G RL++GS G RLW+ ++ +C +G + F + E D A
Sbjct: 16 GGINWLSLSPDGQRLLTGSEDGTARLWST---ADGQCCALLQGHESYVTFCQLE---DEA 69
Query: 1396 VVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE 1455
+ S D ++ V T G ++ GH S VN ++ + + + S
Sbjct: 70 AFTCSADCTIRRWDVLT------------GQCLQVYRGHTSIVNRILVA--NNQLFSSSY 115
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPP--CCGRPEQQRLAAG------YGDGSL 1507
D + RVW++ ++ +F+ L LA+S P P + AAG DG+
Sbjct: 116 DRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTA 175
Query: 1508 RIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQ 1567
+++ V+ + H A+ + T G T +G D + +G RV +H+
Sbjct: 176 KVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHR 235
Query: 1568 GAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASD 1607
G S IC+ L + S D+ V W +D
Sbjct: 236 G---SVICLELV---------NRLVYSGSADRTVKCWLAD 263
Score = 42.7 bits (99), Expect = 0.003
Identities = 85/382 (22%), Positives = 131/382 (34%), Gaps = 94/382 (24%)
Query: 1149 GAQQHWSGHSAEISTLALSHSAQVL---ASASGRSSTTAHCQIRVWDVSGGLCQHLIFPH 1205
G + WS + L H + V + +A C IR WDV G C + H
Sbjct: 37 GTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGH 96
Query: 1206 STTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEP-VHGVAFN-PWDAG 1263
++ V + + +++L + D RT +W + R V +A++ PWD
Sbjct: 97 TSIVNRILVA-NNQLFSSSYD---RTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLP 152
Query: 1264 ELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQV 1323
C EA G LL G++ G
Sbjct: 153 STPCA--------------------------EEAAAGG-----------LLVTGSTDGTA 175
Query: 1324 CVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRCKGSGA 1381
VW +G C + G + L+ G +GS+ +R W + + +LR
Sbjct: 176 KVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR------ 229
Query: 1382 SSVFMEH-------ELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGH 1434
VF EH ELV + V S S D +V + T G R + H
Sbjct: 230 --VFREHRGSVICLELV-NRLVYSGSADRTVKCWLADT------------GECVRTFTAH 274
Query: 1435 RSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQ----VLNQSCLCLAWSPPCC 1490
R V+ + + G T S D R + S EL F+ ++N C
Sbjct: 275 RRNVSALKYHAGT--LFTGSGDACARAFDAQSGELRRVFRGHTFIIN------------C 320
Query: 1491 GRPEQQRLAAGYGDGSLRIFSV 1512
+ Q L DG+LR++ V
Sbjct: 321 IQVHGQVLYTASHDGALRLWDV 342
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/192 (20%), Positives = 76/192 (39%), Gaps = 7/192 (3%)
Query: 618 PGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSA 676
P + + + + GS DG ++W + H G V + + G +
Sbjct: 152 PSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTG 211
Query: 677 TSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLY 736
++ + D LS + R H V+ L + R + + S DRTV+ W T + +
Sbjct: 212 STDATIRAWDILSGEQLRVFREHRGSVICLELVNRL--VYSGSADRTVKCWLADTGECVR 269
Query: 737 DFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDG 796
FT+ A+ +H T F G R+F ++ E+ H + + G
Sbjct: 270 TFTAHRRNVSALKYH--AGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQV--HG 325
Query: 797 RLLFSSCSQGSL 808
++L+++ G+L
Sbjct: 326 QVLYTASHDGAL 337
Score = 41.2 bits (95), Expect = 0.009
Identities = 37/161 (22%), Positives = 65/161 (40%), Gaps = 4/161 (2%)
Query: 649 SSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAM 708
S++ + A+H G ++ + +SPDG R+L+ + G T L + H + V +
Sbjct: 6 SALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL 65
Query: 709 EQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRS 768
E T S D T+R WD+ T Q L + + F R
Sbjct: 66 EDEAA--FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARV 121
Query: 769 FSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLA 809
+S++ ++ E HR V L + L + C++ + A
Sbjct: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA 162
Score = 39.3 bits (90), Expect = 0.034
Identities = 46/224 (20%), Positives = 79/224 (35%), Gaps = 50/224 (22%)
Query: 1425 GTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASME---------------- 1468
G++ R+ + HR +N + SP T SEDG+ R+W+ A +
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
Query: 1469 -------------LVIQFQVLNQSCLCLAWSPPCCGR----PEQQRLAAGYGDGSLRIFS 1511
+ ++ VL CL + Q ++ Y D + R++S
Sbjct: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSY-DRTARVWS 123
Query: 1512 VSRTAMELKMHPHPVALTTVAFSTD--------------GQTVLSGDKDGLVAVSHPCTG 1557
V + M + H + T+A+S G +++G DG V +G
Sbjct: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183
Query: 1558 TTFRVLSDHQGAPISTICVTCKECEDLGVEGTDL--WLAASGDQ 1599
+ L H GA + + T G + W SG+Q
Sbjct: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
Score = 37.4 bits (85), Expect = 0.13
Identities = 39/138 (28%), Positives = 56/138 (40%), Gaps = 7/138 (5%)
Query: 619 GIAISSLSVSPAMCAVGSEDGFLRLW-PLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSAT 677
GI SLS GSEDG RLW D L HE V+ + + SA
Sbjct: 17 GINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSAD 76
Query: 678 SSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYD 737
+ + D L+ + R HT+ V + + QL + S DRT R+W + Q +
Sbjct: 77 CT--IRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSVDKGQMSRE 132
Query: 738 FTSSEDAPCAVTFHPTRP 755
F + C +T + P
Sbjct: 133 FRGHRN--CVLTLAYSAP 148
>gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo
sapiens]
Length = 508
Score = 62.0 bits (149), Expect = 5e-09
Identities = 58/267 (21%), Positives = 108/267 (40%), Gaps = 44/267 (16%)
Query: 1317 GTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRC 1376
G + +WD + C G + L + +V+GSS +R+W V
Sbjct: 222 GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNT------ 275
Query: 1377 KGSGASSVFMEHELVL-----DGAVVSASFDDSVDMGVVGTTAGTLW-FVSWAEGTSTRL 1430
G +++ +E VL +G +V+ S D S+ +W S + T R+
Sbjct: 276 -GEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI----------AVWDMASATDITLRRV 324
Query: 1431 ISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCC 1490
+ GHR+ VN V F + + + S D +++VW+ ++ E V + CL +
Sbjct: 325 LVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY----- 377
Query: 1491 GRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVA 1550
+ + +G D ++R++ + A + H + + F D + ++SG DG +
Sbjct: 378 ---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIK 432
Query: 1551 V---------SHPCTGTTFRVLSDHQG 1568
V P + R L +H G
Sbjct: 433 VWDLQAALDPRAPASTLCLRTLVEHSG 459
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/261 (24%), Positives = 113/261 (43%), Gaps = 33/261 (12%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
+GH+ S L L + +V+ + S S+ +RVWDV+ G + + H+ VL L F
Sbjct: 243 TGHTG--SVLCLQYDERVIVTGSSDST------VRVWDVNTGEVLNTLIHHNEAVLHLRF 294
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGE---LTCVGQG 1271
S + L+VT R++A+W A+ ++ R+ H A N D + ++ G
Sbjct: 295 S--NGLMVTCSKD--RSIAVWDMASATDITLRRVLVG-HRAAVNVVDFDDKYIVSASGDR 349
Query: 1272 TVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAG 1331
T+ W +L + + L Y L+ G+S + +WD G
Sbjct: 350 TIKVWSTSTCEFVRTLNGHKRGI---------ACLQY-RDRLVVSGSSDNTIRLWDIECG 399
Query: 1332 RCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG-ASSVFMEH-- 1388
C E + + + F R+VSG+ G++++W + A + R S +EH
Sbjct: 400 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 459
Query: 1389 ---ELVLDG-AVVSASFDDSV 1405
L D ++S+S DD++
Sbjct: 460 RVFRLQFDEFQIISSSHDDTI 480
Score = 38.1 bits (87), Expect = 0.076
Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 25/166 (15%)
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRT 1515
D S+++W S+E + S LCL + +++ + G D ++R++ V+
Sbjct: 225 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTG 276
Query: 1516 AMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFR-VLSDHQGAPISTI 1574
+ + H A+ + FS S D+ V T T R VL H+ A
Sbjct: 277 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA----- 331
Query: 1575 CVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS 1620
V + +D + ++ASGD+ + VW++ + CE V L+
Sbjct: 332 -VNVVDFDDKYI------VSASGDRTIKVWST----STCEFVRTLN 366
Score = 36.2 bits (82), Expect = 0.29
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
++ E C+ D +++S + D S + HT VL L ++R
Sbjct: 199 IQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER- 257
Query: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
+ T S D TVR+WD+ T + L +A + F
Sbjct: 258 -VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF 294
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 14/117 (11%)
Query: 622 ISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSG 680
I+ L + GS D +RLW ++ + L E HE V C+ D R++S G
Sbjct: 372 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDG 429
Query: 681 HL------GFLDTLSRVYHMLARS---HTAPVLALAMEQRRGQLATVSQDRTVRIWD 728
+ LD + + R+ H+ V L ++ Q+ + S D T+ IWD
Sbjct: 430 KIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo
sapiens]
Length = 529
Score = 62.0 bits (149), Expect = 5e-09
Identities = 58/267 (21%), Positives = 108/267 (40%), Gaps = 44/267 (16%)
Query: 1317 GTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRC 1376
G + +WD + C G + L + +V+GSS +R+W V
Sbjct: 243 GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNT------ 296
Query: 1377 KGSGASSVFMEHELVL-----DGAVVSASFDDSVDMGVVGTTAGTLW-FVSWAEGTSTRL 1430
G +++ +E VL +G +V+ S D S+ +W S + T R+
Sbjct: 297 -GEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI----------AVWDMASATDITLRRV 345
Query: 1431 ISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCC 1490
+ GHR+ VN V F + + + S D +++VW+ ++ E V + CL +
Sbjct: 346 LVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY----- 398
Query: 1491 GRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVA 1550
+ + +G D ++R++ + A + H + + F D + ++SG DG +
Sbjct: 399 ---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIK 453
Query: 1551 V---------SHPCTGTTFRVLSDHQG 1568
V P + R L +H G
Sbjct: 454 VWDLQAALDPRAPASTLCLRTLVEHSG 480
Score = 60.1 bits (144), Expect = 2e-08
Identities = 64/261 (24%), Positives = 113/261 (43%), Gaps = 33/261 (12%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
+GH+ S L L + +V+ + S S+ +RVWDV+ G + + H+ VL L F
Sbjct: 264 TGHTG--SVLCLQYDERVIVTGSSDST------VRVWDVNTGEVLNTLIHHNEAVLHLRF 315
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGE---LTCVGQG 1271
S + L+VT R++A+W A+ ++ R+ H A N D + ++ G
Sbjct: 316 S--NGLMVTCSKD--RSIAVWDMASATDITLRRVLVG-HRAAVNVVDFDDKYIVSASGDR 370
Query: 1272 TVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAG 1331
T+ W +L + + L Y L+ G+S + +WD G
Sbjct: 371 TIKVWSTSTCEFVRTLNGHKRGI---------ACLQY-RDRLVVSGSSDNTIRLWDIECG 420
Query: 1332 RCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSG-ASSVFMEH-- 1388
C E + + + F R+VSG+ G++++W + A + R S +EH
Sbjct: 421 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 480
Query: 1389 ---ELVLDG-AVVSASFDDSV 1405
L D ++S+S DD++
Sbjct: 481 RVFRLQFDEFQIISSSHDDTI 501
Score = 38.1 bits (87), Expect = 0.076
Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 25/166 (15%)
Query: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRT 1515
D S+++W S+E + S LCL + +++ + G D ++R++ V+
Sbjct: 246 DNSIKIWDKTSLECLKVLTGHTGSVLCLQY--------DERVIVTGSSDSTVRVWDVNTG 297
Query: 1516 AMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFR-VLSDHQGAPISTI 1574
+ + H A+ + FS S D+ V T T R VL H+ A
Sbjct: 298 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA----- 352
Query: 1575 CVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLS 1620
V + +D + ++ASGD+ + VW++ + CE V L+
Sbjct: 353 -VNVVDFDDKYI------VSASGDRTIKVWST----STCEFVRTLN 387
Score = 36.2 bits (82), Expect = 0.29
Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 2/98 (2%)
Query: 653 LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRR 712
++ E C+ D +++S + D S + HT VL L ++R
Sbjct: 220 IQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER- 278
Query: 713 GQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
+ T S D TVR+WD+ T + L +A + F
Sbjct: 279 -VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF 315
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 14/117 (11%)
Query: 622 ISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRVLSATSSG 680
I+ L + GS D +RLW ++ + L E HE V C+ D R++S G
Sbjct: 393 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR--CIRFDNKRIVSGAYDG 450
Query: 681 HL------GFLDTLSRVYHMLARS---HTAPVLALAMEQRRGQLATVSQDRTVRIWD 728
+ LD + + R+ H+ V L ++ Q+ + S D T+ IWD
Sbjct: 451 KIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIWD 505
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 61.6 bits (148), Expect = 6e-09
Identities = 37/132 (28%), Positives = 65/132 (49%), Gaps = 3/132 (2%)
Query: 1429 RLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP- 1487
+ GH ++VN + + P + A+CS+D ++++W++ V Q N+ + WSP
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402
Query: 1488 -PCCGRPEQQ-RLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDK 1545
P P LA+ D ++R++ V R + H + +VAFS DG+ + SG
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSF 462
Query: 1546 DGLVAVSHPCTG 1557
D V + + TG
Sbjct: 463 DKCVHIWNTQTG 474
Score = 50.4 bits (119), Expect = 1e-05
Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 17/111 (15%)
Query: 1157 HSAEISTLALSHSAQ---------VLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHST 1207
H+ EI T+ S + +LASAS S+ +R+WDV G+C H + H
Sbjct: 390 HNKEIYTIKWSPTGPGTNNPNANLMLASASFDST------VRLWDVDRGICIHTLTKHQE 443
Query: 1208 TVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFN 1258
V ++AFSPD R L + G D + + +W T T LV S R + V +N
Sbjct: 444 PVYSVAFSPDGRYLAS-GSFD-KCVHIWNTQTGALVHSYRGTGGIFEVCWN 492
Score = 41.6 bits (96), Expect = 0.007
Identities = 49/234 (20%), Positives = 86/234 (36%), Gaps = 15/234 (6%)
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 690
+ A GS DGF R+W D + +H+GP+ ++ + G +LSA D +
Sbjct: 239 LLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTG 298
Query: 691 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H+AP L + Q A+ S D + + L + + F + A+ +
Sbjct: 299 EAKQQFPFHSAPALDVDW-QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKW 357
Query: 751 HPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGL--------TATPDGRLLFSS 802
PT ++ +S++ + + H + + T P+ L+ +S
Sbjct: 358 DPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
Query: 803 CSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC 856
S S + W V R ++A S DGR LA +C
Sbjct: 418 ASFDSTVRL------WDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKC 465
Score = 39.3 bits (90), Expect = 0.034
Identities = 43/189 (22%), Positives = 74/189 (39%), Gaps = 33/189 (17%)
Query: 1154 WSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
+ GH+ E++ + + +LAS S + +++W + C H + H+ + +
Sbjct: 345 FQGHTNEVNAIKWDPTGNLLASCSDDMT------LKIWSMKQDNCVHDLQAHNKEIYTIK 398
Query: 1214 FS--------PDDRLLVTLGDHDGRTLALW----GTATYDLVSSTRLPEPVHGVAFNPWD 1261
+S P+ L++ D T+ LW G + L T+ EPV+ VAF+P
Sbjct: 399 WSPTGPGTNNPNANLMLASASFDS-TVRLWDVDRGICIHTL---TKHQEPVYSVAFSPDG 454
Query: 1262 AGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAP-PLLYCGTSS 1320
+ V W Q S + G G + +C+ A + S
Sbjct: 455 RYLASGSFDKCVHIWNTQTGALVHSYR----------GTGGIFEVCWNAAGDKVGASASD 504
Query: 1321 GQVCVWDTR 1329
G VCV D R
Sbjct: 505 GSVCVLDLR 513
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 61.6 bits (148), Expect = 6e-09
Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 1429 RLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP- 1487
+ GH ++VN + + P A+CS+D ++++W++ + Q N+ + WSP
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 1488 -PCCGRPEQQ-RLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDK 1545
P P LA+ D ++R++ + R + H + +VAFS DG+ + SG
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 1546 DGLVAVSHPCTG 1557
D V + + +G
Sbjct: 475 DKCVHIWNTQSG 486
Score = 50.4 bits (119), Expect = 1e-05
Identities = 30/105 (28%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 1157 HSAEISTLALSHSAQVLASASGR---SSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
H+ EI T+ S + ++ + +S + +R+WD+ G+C H + H V ++A
Sbjct: 402 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 461
Query: 1214 FSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFN 1258
FSPD + L + G D + + +W T + +LV S R + V +N
Sbjct: 462 FSPDGKYLAS-GSFD-KCVHIWNTQSGNLVHSYRGTGGIFEVCWN 504
Score = 44.7 bits (104), Expect = 8e-04
Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 33/189 (17%)
Query: 1154 WSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
+ GH+ E++ + S +LAS S + +++W + +C H + H+ + +
Sbjct: 357 FQGHTNEVNAIKWDPSGMLLASCSDDMT------LKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 1214 FS--------PDDRLLVTLGDHDGRTLALW----GTATYDLVSSTRLPEPVHGVAFNPWD 1261
+S P+ +++ D T+ LW G T+ L T+ EPV+ VAF+P
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDS-TVRLWDIERGVCTHTL---TKHQEPVYSVAFSP-- 464
Query: 1262 AGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-PPLLYCGTSS 1320
G+ G + + ++ R G G + +C+ A + S
Sbjct: 465 DGKYLASGSFDKCVHIWNTQSGNLVHSYR--------GTGGIFEVCWNARGDKVGASASD 516
Query: 1321 GQVCVWDTR 1329
G VCV D R
Sbjct: 517 GSVCVLDLR 525
Score = 39.3 bits (90), Expect = 0.034
Identities = 47/234 (20%), Positives = 88/234 (37%), Gaps = 15/234 (6%)
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 690
+ A GS DGF R+W D + +H+GP+ ++ + G +LSA D +
Sbjct: 251 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTG 310
Query: 691 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H+AP L + Q A+ S D + + L + + F + A+ +
Sbjct: 311 EAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 369
Query: 751 HPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAV-------TG-LTATPDGRLLFSS 802
P+ ++ +S++ + + H + TG T+ P+ ++ +S
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429
Query: 803 CSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC 856
S S + W + R ++A S DG+ LA +C
Sbjct: 430 ASFDSTVRL------WDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Score = 37.7 bits (86), Expect = 0.099
Identities = 74/351 (21%), Positives = 132/351 (37%), Gaps = 68/351 (19%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVS----GGLCQHLI--------- 1202
GH +E+ A + + +LAS SG S+ R+W+++ GG Q ++
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTA------RIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 1203 -FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPE-PVHGVAFNPW 1260
P + V +L ++ + LL T G +DG +W T +L S+ + P+ + +N
Sbjct: 233 DVPSNKDVTSLDWNTNGTLLAT-GSYDGFA-RIW-TEDGNLASTLGQHKGPIFALKWNRK 289
Query: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
L+ T W A P + T + S
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-----------ASCS 338
Query: 1321 GQVCVWDTRAG--RCFLSWEADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGA------ 1370
+C+ R G R +++ + + + SG L S S L++W++
Sbjct: 339 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 398
Query: 1371 -------VSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWA 1423
+ ++ +G ++ ++L SASFD +V LW +
Sbjct: 399 LQAHNKEIYTIKWSPTGPATSNPNSNIML----ASASFDSTV----------RLWDIE-- 442
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQ 1474
G T ++ H+ V V FSP + A+ S D V +W S LV ++
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493
Score = 31.6 bits (70), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 921 RELPGVHPEPCPSLTLSEDARFLLIAAG--RTIKVWDYATQASPGPQVYIGHSEPVQAVA 978
+E+ + P T + ++ +L +A T+++WD + H EPV +VA
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVA 461
Query: 979 FSPDQQQVLSAG--DAVFLWD 997
FSPD + + S V +W+
Sbjct: 462 FSPDGKYLASGSFDKCVHIWN 482
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 61.6 bits (148), Expect = 6e-09
Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 1429 RLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP- 1487
+ GH ++VN + + P A+CS+D ++++W++ + Q N+ + WSP
Sbjct: 355 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414
Query: 1488 -PCCGRPEQQ-RLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDK 1545
P P LA+ D ++R++ + R + H + +VAFS DG+ + SG
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 474
Query: 1546 DGLVAVSHPCTG 1557
D V + + +G
Sbjct: 475 DKCVHIWNTQSG 486
Score = 50.4 bits (119), Expect = 1e-05
Identities = 30/105 (28%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 1157 HSAEISTLALSHSAQVLASASGR---SSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
H+ EI T+ S + ++ + +S + +R+WD+ G+C H + H V ++A
Sbjct: 402 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 461
Query: 1214 FSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFN 1258
FSPD + L + G D + + +W T + +LV S R + V +N
Sbjct: 462 FSPDGKYLAS-GSFD-KCVHIWNTQSGNLVHSYRGTGGIFEVCWN 504
Score = 44.7 bits (104), Expect = 8e-04
Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 33/189 (17%)
Query: 1154 WSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
+ GH+ E++ + S +LAS S + +++W + +C H + H+ + +
Sbjct: 357 FQGHTNEVNAIKWDPSGMLLASCSDDMT------LKIWSMKQEVCIHDLQAHNKEIYTIK 410
Query: 1214 FS--------PDDRLLVTLGDHDGRTLALW----GTATYDLVSSTRLPEPVHGVAFNPWD 1261
+S P+ +++ D T+ LW G T+ L T+ EPV+ VAF+P
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDS-TVRLWDIERGVCTHTL---TKHQEPVYSVAFSP-- 464
Query: 1262 AGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-PPLLYCGTSS 1320
G+ G + + ++ R G G + +C+ A + S
Sbjct: 465 DGKYLASGSFDKCVHIWNTQSGNLVHSYR--------GTGGIFEVCWNARGDKVGASASD 516
Query: 1321 GQVCVWDTR 1329
G VCV D R
Sbjct: 517 GSVCVLDLR 525
Score = 39.3 bits (90), Expect = 0.034
Identities = 47/234 (20%), Positives = 88/234 (37%), Gaps = 15/234 (6%)
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 690
+ A GS DGF R+W D + +H+GP+ ++ + G +LSA D +
Sbjct: 251 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTG 310
Query: 691 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H+AP L + Q A+ S D + + L + + F + A+ +
Sbjct: 311 EAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 369
Query: 751 HPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAV-------TG-LTATPDGRLLFSS 802
P+ ++ +S++ + + H + TG T+ P+ ++ +S
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 429
Query: 803 CSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC 856
S S + W + R ++A S DG+ LA +C
Sbjct: 430 ASFDSTVRL------WDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 477
Score = 37.7 bits (86), Expect = 0.099
Identities = 74/351 (21%), Positives = 132/351 (37%), Gaps = 68/351 (19%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVS----GGLCQHLI--------- 1202
GH +E+ A + + +LAS SG S+ R+W+++ GG Q ++
Sbjct: 179 GHESEVFICAWNPVSDLLASGSGDSTA------RIWNLNENSNGGSTQLVLRHCIREGGH 232
Query: 1203 -FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPE-PVHGVAFNPW 1260
P + V +L ++ + LL T G +DG +W T +L S+ + P+ + +N
Sbjct: 233 DVPSNKDVTSLDWNTNGTLLAT-GSYDGFA-RIW-TEDGNLASTLGQHKGPIFALKWNRK 289
Query: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
L+ T W A P + T + S
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-----------ASCS 338
Query: 1321 GQVCVWDTRAG--RCFLSWEADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGA------ 1370
+C+ R G R +++ + + + SG L S S L++W++
Sbjct: 339 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 398
Query: 1371 -------VSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWA 1423
+ ++ +G ++ ++L SASFD +V LW +
Sbjct: 399 LQAHNKEIYTIKWSPTGPATSNPNSNIML----ASASFDSTV----------RLWDIE-- 442
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQ 1474
G T ++ H+ V V FSP + A+ S D V +W S LV ++
Sbjct: 443 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493
Score = 31.6 bits (70), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 921 RELPGVHPEPCPSLTLSEDARFLLIAAG--RTIKVWDYATQASPGPQVYIGHSEPVQAVA 978
+E+ + P T + ++ +L +A T+++WD + H EPV +VA
Sbjct: 404 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVA 461
Query: 979 FSPDQQQVLSAG--DAVFLWD 997
FSPD + + S V +W+
Sbjct: 462 FSPDGKYLASGSFDKCVHIWN 482
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 61.6 bits (148), Expect = 6e-09
Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 1429 RLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP- 1487
+ GH ++VN + + P A+CS+D ++++W++ + Q N+ + WSP
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 1488 -PCCGRPEQQ-RLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDK 1545
P P LA+ D ++R++ + R + H + +VAFS DG+ + SG
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 1546 DGLVAVSHPCTG 1557
D V + + +G
Sbjct: 526 DKCVHIWNTQSG 537
Score = 50.4 bits (119), Expect = 1e-05
Identities = 30/105 (28%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 1157 HSAEISTLALSHSAQVLASASGR---SSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
H+ EI T+ S + ++ + +S + +R+WD+ G+C H + H V ++A
Sbjct: 453 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 512
Query: 1214 FSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFN 1258
FSPD + L + G D + + +W T + +LV S R + V +N
Sbjct: 513 FSPDGKYLAS-GSFD-KCVHIWNTQSGNLVHSYRGTGGIFEVCWN 555
Score = 44.7 bits (104), Expect = 8e-04
Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 33/189 (17%)
Query: 1154 WSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
+ GH+ E++ + S +LAS S + +++W + +C H + H+ + +
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMT------LKIWSMKQEVCIHDLQAHNKEIYTIK 461
Query: 1214 FS--------PDDRLLVTLGDHDGRTLALW----GTATYDLVSSTRLPEPVHGVAFNPWD 1261
+S P+ +++ D T+ LW G T+ L T+ EPV+ VAF+P
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDS-TVRLWDIERGVCTHTL---TKHQEPVYSVAFSP-- 515
Query: 1262 AGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-PPLLYCGTSS 1320
G+ G + + ++ R G G + +C+ A + S
Sbjct: 516 DGKYLASGSFDKCVHIWNTQSGNLVHSYR--------GTGGIFEVCWNARGDKVGASASD 567
Query: 1321 GQVCVWDTR 1329
G VCV D R
Sbjct: 568 GSVCVLDLR 576
Score = 39.3 bits (90), Expect = 0.034
Identities = 47/234 (20%), Positives = 88/234 (37%), Gaps = 15/234 (6%)
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 690
+ A GS DGF R+W D + +H+GP+ ++ + G +LSA D +
Sbjct: 302 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTG 361
Query: 691 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H+AP L + Q A+ S D + + L + + F + A+ +
Sbjct: 362 EAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
Query: 751 HPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAV-------TG-LTATPDGRLLFSS 802
P+ ++ +S++ + + H + TG T+ P+ ++ +S
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
Query: 803 CSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC 856
S S + W + R ++A S DG+ LA +C
Sbjct: 481 ASFDSTVRL------WDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Score = 37.7 bits (86), Expect = 0.099
Identities = 74/351 (21%), Positives = 132/351 (37%), Gaps = 68/351 (19%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVS----GGLCQHLI--------- 1202
GH +E+ A + + +LAS SG S+ R+W+++ GG Q ++
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTA------RIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 1203 -FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPE-PVHGVAFNPW 1260
P + V +L ++ + LL T G +DG +W T +L S+ + P+ + +N
Sbjct: 284 DVPSNKDVTSLDWNTNGTLLAT-GSYDGFA-RIW-TEDGNLASTLGQHKGPIFALKWNRK 340
Query: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
L+ T W A P + T + S
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-----------ASCS 389
Query: 1321 GQVCVWDTRAG--RCFLSWEADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGA------ 1370
+C+ R G R +++ + + + SG L S S L++W++
Sbjct: 390 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449
Query: 1371 -------VSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWA 1423
+ ++ +G ++ ++L SASFD +V LW +
Sbjct: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIML----ASASFDSTV----------RLWDIE-- 493
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQ 1474
G T ++ H+ V V FSP + A+ S D V +W S LV ++
Sbjct: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544
Score = 31.6 bits (70), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 921 RELPGVHPEPCPSLTLSEDARFLLIAAG--RTIKVWDYATQASPGPQVYIGHSEPVQAVA 978
+E+ + P T + ++ +L +A T+++WD + H EPV +VA
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVA 512
Query: 979 FSPDQQQVLSAG--DAVFLWD 997
FSPD + + S V +W+
Sbjct: 513 FSPDGKYLASGSFDKCVHIWN 533
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 61.6 bits (148), Expect = 6e-09
Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 1429 RLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSP- 1487
+ GH ++VN + + P A+CS+D ++++W++ + Q N+ + WSP
Sbjct: 406 KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465
Query: 1488 -PCCGRPEQQ-RLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDK 1545
P P LA+ D ++R++ + R + H + +VAFS DG+ + SG
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSF 525
Query: 1546 DGLVAVSHPCTG 1557
D V + + +G
Sbjct: 526 DKCVHIWNTQSG 537
Score = 50.4 bits (119), Expect = 1e-05
Identities = 30/105 (28%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 1157 HSAEISTLALSHSAQVLASASGR---SSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
H+ EI T+ S + ++ + +S + +R+WD+ G+C H + H V ++A
Sbjct: 453 HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVA 512
Query: 1214 FSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFN 1258
FSPD + L + G D + + +W T + +LV S R + V +N
Sbjct: 513 FSPDGKYLAS-GSFD-KCVHIWNTQSGNLVHSYRGTGGIFEVCWN 555
Score = 44.7 bits (104), Expect = 8e-04
Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 33/189 (17%)
Query: 1154 WSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALA 1213
+ GH+ E++ + S +LAS S + +++W + +C H + H+ + +
Sbjct: 408 FQGHTNEVNAIKWDPSGMLLASCSDDMT------LKIWSMKQEVCIHDLQAHNKEIYTIK 461
Query: 1214 FS--------PDDRLLVTLGDHDGRTLALW----GTATYDLVSSTRLPEPVHGVAFNPWD 1261
+S P+ +++ D T+ LW G T+ L T+ EPV+ VAF+P
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDS-TVRLWDIERGVCTHTL---TKHQEPVYSVAFSP-- 515
Query: 1262 AGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGA-PPLLYCGTSS 1320
G+ G + + ++ R G G + +C+ A + S
Sbjct: 516 DGKYLASGSFDKCVHIWNTQSGNLVHSYR--------GTGGIFEVCWNARGDKVGASASD 567
Query: 1321 GQVCVWDTR 1329
G VCV D R
Sbjct: 568 GSVCVLDLR 576
Score = 39.3 bits (90), Expect = 0.034
Identities = 47/234 (20%), Positives = 88/234 (37%), Gaps = 15/234 (6%)
Query: 631 MCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSR 690
+ A GS DGF R+W D + +H+GP+ ++ + G +LSA D +
Sbjct: 302 LLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTG 361
Query: 691 VYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H+AP L + Q A+ S D + + L + + F + A+ +
Sbjct: 362 EAKQQFPFHSAPALDVDW-QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKW 420
Query: 751 HPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAV-------TG-LTATPDGRLLFSS 802
P+ ++ +S++ + + H + TG T+ P+ ++ +S
Sbjct: 421 DPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLAS 480
Query: 803 CSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRC 856
S S + W + R ++A S DG+ LA +C
Sbjct: 481 ASFDSTVRL------WDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKC 528
Score = 37.7 bits (86), Expect = 0.099
Identities = 74/351 (21%), Positives = 132/351 (37%), Gaps = 68/351 (19%)
Query: 1156 GHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVS----GGLCQHLI--------- 1202
GH +E+ A + + +LAS SG S+ R+W+++ GG Q ++
Sbjct: 230 GHESEVFICAWNPVSDLLASGSGDSTA------RIWNLNENSNGGSTQLVLRHCIREGGH 283
Query: 1203 -FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPE-PVHGVAFNPW 1260
P + V +L ++ + LL T G +DG +W T +L S+ + P+ + +N
Sbjct: 284 DVPSNKDVTSLDWNTNGTLLAT-GSYDGFA-RIW-TEDGNLASTLGQHKGPIFALKWNRK 340
Query: 1261 DAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSS 1320
L+ T W A P + T + S
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-----------ASCS 389
Query: 1321 GQVCVWDTRAG--RCFLSWEADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGA------ 1370
+C+ R G R +++ + + + SG L S S L++W++
Sbjct: 390 TDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHD 449
Query: 1371 -------VSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWA 1423
+ ++ +G ++ ++L SASFD +V LW +
Sbjct: 450 LQAHNKEIYTIKWSPTGPATSNPNSNIML----ASASFDSTV----------RLWDIE-- 493
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQ 1474
G T ++ H+ V V FSP + A+ S D V +W S LV ++
Sbjct: 494 RGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544
Score = 31.6 bits (70), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 921 RELPGVHPEPCPSLTLSEDARFLLIAAG--RTIKVWDYATQASPGPQVYIGHSEPVQAVA 978
+E+ + P T + ++ +L +A T+++WD + H EPV +VA
Sbjct: 455 KEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI--ERGVCTHTLTKHQEPVYSVA 512
Query: 979 FSPDQQQVLSAG--DAVFLWD 997
FSPD + + S V +W+
Sbjct: 513 FSPDGKYLASGSFDKCVHIWN 533
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 61.6 bits (148), Expect = 6e-09
Identities = 79/367 (21%), Positives = 138/367 (37%), Gaps = 34/367 (9%)
Query: 1214 FSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGT 1272
F+ LL ++G + TL +W + T+ + V V FNP +LT G G
Sbjct: 236 FNYSGNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKEEQLTTSGSGH 295
Query: 1273 VTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGR 1332
+ FW + + LQ + + ++ + G+ G + +W+ +
Sbjct: 296 IKFWEMAFTFTGLKLQGSLGRFGKTITT-DIEGYMELPDGKVLSGSEWGNMLLWEGGLIK 354
Query: 1333 CFL----SWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRC-KGSGASSVFME 1387
L S +G I ++ +++ S G +R+W + +G +
Sbjct: 355 VELCRGTSKSCHNGPINQIMLYEGEVITVGSDGYVRIWDFETIDTADVIDETGLLEIEPI 414
Query: 1388 HELVLDGAVVSASFDDSVDMG----VVGTTAGTLWFVSWAEGTSTR----LISGHRSKVN 1439
+EL +D V S + G + G +W + + T+ L S H +
Sbjct: 415 NELQVDKNVNLFSMIKMNETGNNFWLAQDANGAIWKLDLSFSNITQDPECLFSFHSGAIE 474
Query: 1440 EVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLA 1499
V SP AT + D SVR++ AS + Q + Q L W P Q +
Sbjct: 475 AVAVSPLTYLMATTALDCSVRIYDFASKTPLAQMK-FKQGGTALVWVPRMVNFTGAQ-II 532
Query: 1500 AGYGDGSLRIFS---------------VSRTAMELKM--HPHPVALTTVAFSTDGQTVLS 1542
G+ DG +RI + ++LK PH +T +A+ DG+ + +
Sbjct: 533 VGFEDGVVRILELYDPKGLTIFAGRKKILDADIQLKQVFKPHTACVTALAYERDGEILAT 592
Query: 1543 GDKDGLV 1549
G KD V
Sbjct: 593 GSKDQTV 599
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 60.8 bits (146), Expect = 1e-08
Identities = 87/371 (23%), Positives = 140/371 (37%), Gaps = 58/371 (15%)
Query: 1211 ALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEP-VHGVAFNP---WDAGELT 1266
A AF LLVT G G L ++L+ S + + + VA N W A
Sbjct: 293 AAAFHKKSHLLVT-GFASG-IFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIA--FG 348
Query: 1267 CVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAP-PLLYCGTSSGQVCV 1325
C G G + W Q + Q + +L Y + G G+V V
Sbjct: 349 CSGLGQLLVWEWQSESYVLKQQGH---------FNSMVALAYSPDGQYIVTGGDDGKVKV 399
Query: 1326 WDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLWAVGAVSELRCKGSGASS 1383
W+T +G CF+++ G+ + F+ G +V+ S G +R + + R S +
Sbjct: 400 WNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPT 459
Query: 1384 VFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVF 1443
F + G +VSA DS ++ V G L V +SGH ++ + F
Sbjct: 460 QFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDV----------LSGHEGPISGLCF 509
Query: 1444 SPGESHCATCSEDGSVRVW------------ALASMELVIQFQ-------VLNQSCLCLA 1484
+P +S A+ S D +VR+W AL S L + F+ V +
Sbjct: 510 NPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITF 569
Query: 1485 WSPPCCGRPEQQRLAAGYGDG--SLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLS 1542
W P + + G +G L+ + K A T + +S DG ++L+
Sbjct: 570 WDP-------ENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILA 622
Query: 1543 GDKDGLVAVSH 1553
G V + H
Sbjct: 623 GGMSKFVCIYH 633
Score = 46.2 bits (108), Expect = 3e-04
Identities = 74/328 (22%), Positives = 130/328 (39%), Gaps = 40/328 (12%)
Query: 616 SGPGIAISSLSVSPAMCAVGSED-GFLRLWPLDFSSVLLEAE-HEGPVSSVCVSPDGLRV 673
S IA +++ S A G G L +W S +L+ + H + ++ SPDG +
Sbjct: 329 SDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYI 388
Query: 674 LSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQ 733
++ G + +TLS + H++ V + + T S D TVR +DL +
Sbjct: 389 VTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYR 448
Query: 734 QLYDFTSSEDAPCAVTFHPTRPTFFCG---------FSSGAVRSF-----SLEAAEVLVE 779
FTS RPT F S+GA SF S++ +L
Sbjct: 449 NFRTFTS------------PRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDV 496
Query: 780 HTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQW---HVLRVAADMVCPDAPASP 836
+ H G ++GL P +L S+ ++ + D W L + +D +
Sbjct: 497 LSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFD-SWRTKETLALTSDALAVTFRPDG 555
Query: 837 SALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRL----DSAMAVCF 892
+ LAV+ + F P T GS L+ LD +++ + A+C+
Sbjct: 556 AELAVATLNSQITFWDPENAVQT--GSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCY 613
Query: 893 GPAALGHLLVSTSSNRVVVLDAVSGRII 920
+A GH +++ ++ V + V +I+
Sbjct: 614 --SADGHSILAGGMSKFVCIYHVREQIL 639
Score = 41.6 bits (96), Expect = 0.007
Identities = 40/182 (21%), Positives = 70/182 (38%), Gaps = 7/182 (3%)
Query: 1396 VVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLIS-GHRSKVNEVVFSPGESHCATCS 1454
+ +A+F + V G +G E +S +S + + S G+ CS
Sbjct: 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCS 350
Query: 1455 EDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSR 1514
G + VW S V++ Q S + LA+SP + Q + G DG +++++
Sbjct: 351 GLGQLLVWEWQSESYVLKQQGHFNSMVALAYSP------DGQYIVTGGDDGKVKVWNTLS 404
Query: 1515 TAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTI 1574
+ H +T V F+ G V++ DG V FR + + S +
Sbjct: 405 GFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCV 464
Query: 1575 CV 1576
V
Sbjct: 465 AV 466
Score = 40.0 bits (92), Expect = 0.020
Identities = 54/172 (31%), Positives = 77/172 (44%), Gaps = 25/172 (14%)
Query: 1205 HSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTAT-YDLVSSTRLPEPVHGVAFNPWDAG 1263
H +++ALA+SPD + +VT GD DG+ + +W T + + V+ T V GV F
Sbjct: 372 HFNSMVALAYSPDGQYIVTGGD-DGK-VKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
Query: 1264 ELTCVGQGTV-TFWLLQQRGADISLQVRREPVPE-----AVGA-GELTSLCYGAPPLLYC 1316
+T GTV F L + R + + P P AV A GE+ S GA
Sbjct: 430 VVTSSMDGTVRAFDLHRYR----NFRTFTSPRPTQFSCVAVDASGEIVSA--GA------ 477
Query: 1317 GTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFS--GSRLVSGSSTGRLRLW 1366
S ++ VW + GR +G I L F+ S L S S +RLW
Sbjct: 478 -QDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
Score = 32.0 bits (71), Expect = 5.4
Identities = 41/193 (21%), Positives = 71/193 (36%), Gaps = 30/193 (15%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
S + S +A+ S +++++ + S +I VW + G ++ H + L F
Sbjct: 455 SPRPTQFSCVAVDASGEIVSAGAQDSF-----EIFVWSMQTGRLLDVLSGHEGPISGLCF 509
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVH------GVAFNPWDAGELTCV 1268
+P +L + +T+ LW D+ S R E + V F P A
Sbjct: 510 NPMKSVLASAS--WDKTVRLW-----DMFDSWRTKETLALTSDALAVTFRPDGAELAVAT 562
Query: 1269 GQGTVTFWLLQQRGADISLQVRRE-----------PVPEAVGAGELTSLCYGAP-PLLYC 1316
+TFW + S++ R + A T+LCY A +
Sbjct: 563 LNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILA 622
Query: 1317 GTSSGQVCVWDTR 1329
G S VC++ R
Sbjct: 623 GGMSKFVCIYHVR 635
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 60.5 bits (145), Expect = 1e-08
Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 32/252 (12%)
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCL 1483
+G + ISGH+ +++V +S + + S+D ++++W ++S + + + + C
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC- 134
Query: 1484 AWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHP-HPVALTTVAFSTDGQTVLS 1542
C P+ + +G D S+RI+ V +T LK P H ++ V F+ DG ++S
Sbjct: 135 -----CNFNPQSNLIVSGSFDESVRIWDV-KTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 1543 GDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVS 1602
DGL + +G + L D P+S + G + LAA+ D +
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV--------KFSPNGKYI-LAATLDNTLK 239
Query: 1603 VWASDWLRNHCELVDWLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVI-I 1661
+W D+ + C T T GH F + ++ G ++ I
Sbjct: 240 LW--DYSKGKC-----------LKTYT-GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 1662 YNLCQKQVVEKI 1673
+NL K++V+K+
Sbjct: 286 WNLQTKEIVQKL 297
Score = 50.1 bits (118), Expect = 2e-05
Identities = 63/260 (24%), Positives = 100/260 (38%), Gaps = 34/260 (13%)
Query: 1354 LVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTT 1413
LVS S L++W V + L+ ++ VF + +VS SFD+SV
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV-------- 153
Query: 1414 AGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQF 1473
+W V G + + H V+ V F+ S + S DG R+W AS + +
Sbjct: 154 --RIWDVK--TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--- 206
Query: 1474 QVLNQSCLCLAWSPPCC---GRPEQQRLAAGYGDGSLRI--FSVSRTAMELKMHPHPVAL 1528
L +PP P + + A D +L++ +S + H +
Sbjct: 207 -----KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 1529 TTVAFS-TDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVE 1587
FS T G+ ++SG +D LV + + T + L H IST C E
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--------TE 313
Query: 1588 GTDLWLAASGDQRVSVWASD 1607
A D+ + +W SD
Sbjct: 314 NIIASAALENDKTIKLWKSD 333
Score = 48.1 bits (113), Expect = 7e-05
Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 22/217 (10%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
+GH+ +S++ S + + LAS+S A I++W G + I H + +A+
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSS------ADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTV 1273
S D LLV+ D +TL +W ++ + + + V FNP ++ +V
Sbjct: 96 SSDSNLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 1274 TFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVC-VWDTRAGR 1332
W ++ +L +PV +++ + L +S +C +WDT +G+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPV---------SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 1333 CFLSWEADDG-GIGLLLFS--GSRLVSGSSTGRLRLW 1366
C + DD + + FS G +++ + L+LW
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/163 (22%), Positives = 64/163 (39%)
Query: 655 AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQ 714
A H VSSV SP+G + S+++ + + H + +A
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 715 LATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAA 774
L + S D+T++IWD+++ + L + F+P G +VR + ++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 775 EVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQ 817
+ L H V+ + DG L+ SS G + A Q
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 41.2 bits (95), Expect = 0.009
Identities = 39/161 (24%), Positives = 68/161 (42%), Gaps = 12/161 (7%)
Query: 1120 GRANMVWRPDTGFFAYTCG-RLVVVEDLHSG-AQQHWSGHSAEISTLALSHSAQVLASAS 1177
G +++ W D+ + + + D+ SG + GHS + + + ++ S S
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148
Query: 1178 GRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGT 1237
S +R+WDV G C + HS V A+ F+ D L+V+ +DG +W T
Sbjct: 149 FDES------VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS-SSYDG-LCRIWDT 200
Query: 1238 ATYDLVSSTRLPE--PVHGVAFNPWDAGELTCVGQGTVTFW 1276
A+ + + + PV V F+P L T+ W
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/130 (23%), Positives = 50/130 (38%), Gaps = 11/130 (8%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GH +S +A S+LL SA +++WD +G+CL + + V +F+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142
Query: 467 LLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQG 526
L+ D R V G+ + AH+D V A ++S G
Sbjct: 143 LIVSGSFDESVRIWDVK--------TGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYDG 193
Query: 527 SVRLWRLRGG 536
R+W G
Sbjct: 194 LCRIWDTASG 203
Score = 32.7 bits (73), Expect = 3.2
Identities = 21/82 (25%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GH++ V + S+L+ S +R+WD +TG+CL + V ++ F+ G+
Sbjct: 127 GHSNYVFCCNFNPQSNLIVSGSF--DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 467 LLCGVGKDHHGRTMVVAWGTGQ 488
L+ V + G + +GQ
Sbjct: 185 LI--VSSSYDGLCRIWDTASGQ 204
Score = 32.7 bits (73), Expect = 3.2
Identities = 32/123 (26%), Positives = 45/123 (36%), Gaps = 5/123 (4%)
Query: 636 SEDGFLRLWPLDFSSVL--LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYH 693
S DG R+W L L + PVS V SP+G +L+AT L D
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 694 MLARSHTAP---VLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H + A + + S+D V IW+L T + + D +
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 751 HPT 753
HPT
Sbjct: 310 HPT 312
Score = 31.6 bits (70), Expect = 7.1
Identities = 31/134 (23%), Positives = 62/134 (46%), Gaps = 9/134 (6%)
Query: 861 MGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALG---HLLVSTSSNRVV-VLDAVS 916
+ S+S D+L+++ G D + S + A +LLVS S ++ + + D S
Sbjct: 60 LASSSADKLIKI-WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118
Query: 917 GRIIRELPGVHPEPCPSLTLSEDARFLLIAA-GRTIKVWDYATQASPGPQVYIGHSEPVQ 975
G+ ++ L G H + + ++ + ++++WD T + HS+PV
Sbjct: 119 GKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL--KTLPAHSDPVS 175
Query: 976 AVAFSPDQQQVLSA 989
AV F+ D ++S+
Sbjct: 176 AVHFNRDGSLIVSS 189
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 60.5 bits (145), Expect = 1e-08
Identities = 58/252 (23%), Positives = 110/252 (43%), Gaps = 32/252 (12%)
Query: 1424 EGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCL 1483
+G + ISGH+ +++V +S + + S+D ++++W ++S + + + + C
Sbjct: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC- 134
Query: 1484 AWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHP-HPVALTTVAFSTDGQTVLS 1542
C P+ + +G D S+RI+ V +T LK P H ++ V F+ DG ++S
Sbjct: 135 -----CNFNPQSNLIVSGSFDESVRIWDV-KTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 1543 GDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVS 1602
DGL + +G + L D P+S + G + LAA+ D +
Sbjct: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV--------KFSPNGKYI-LAATLDNTLK 239
Query: 1603 VWASDWLRNHCELVDWLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVI-I 1661
+W D+ + C T T GH F + ++ G ++ I
Sbjct: 240 LW--DYSKGKC-----------LKTYT-GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
Query: 1662 YNLCQKQVVEKI 1673
+NL K++V+K+
Sbjct: 286 WNLQTKEIVQKL 297
Score = 50.1 bits (118), Expect = 2e-05
Identities = 63/260 (24%), Positives = 100/260 (38%), Gaps = 34/260 (13%)
Query: 1354 LVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTT 1413
LVS S L++W V + L+ ++ VF + +VS SFD+SV
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV-------- 153
Query: 1414 AGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQF 1473
+W V G + + H V+ V F+ S + S DG R+W AS + +
Sbjct: 154 --RIWDVK--TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--- 206
Query: 1474 QVLNQSCLCLAWSPPCC---GRPEQQRLAAGYGDGSLRI--FSVSRTAMELKMHPHPVAL 1528
L +PP P + + A D +L++ +S + H +
Sbjct: 207 -----KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 1529 TTVAFS-TDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVE 1587
FS T G+ ++SG +D LV + + T + L H IST C E
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--------TE 313
Query: 1588 GTDLWLAASGDQRVSVWASD 1607
A D+ + +W SD
Sbjct: 314 NIIASAALENDKTIKLWKSD 333
Score = 48.1 bits (113), Expect = 7e-05
Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 22/217 (10%)
Query: 1155 SGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAF 1214
+GH+ +S++ S + + LAS+S A I++W G + I H + +A+
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSS------ADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 1215 SPDDRLLVTLGDHDGRTLALWGTATYDLVSSTR-LPEPVHGVAFNPWDAGELTCVGQGTV 1273
S D LLV+ D +TL +W ++ + + + V FNP ++ +V
Sbjct: 96 SSDSNLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 1274 TFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVC-VWDTRAGR 1332
W ++ +L +PV +++ + L +S +C +WDT +G+
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPV---------SAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 1333 CFLSWEADDG-GIGLLLFS--GSRLVSGSSTGRLRLW 1366
C + DD + + FS G +++ + L+LW
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/163 (22%), Positives = 64/163 (39%)
Query: 655 AEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQ 714
A H VSSV SP+G + S+++ + + H + +A
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
Query: 715 LATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAA 774
L + S D+T++IWD+++ + L + F+P G +VR + ++
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 775 EVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQ 817
+ L H V+ + DG L+ SS G + A Q
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Score = 41.2 bits (95), Expect = 0.009
Identities = 39/161 (24%), Positives = 68/161 (42%), Gaps = 12/161 (7%)
Query: 1120 GRANMVWRPDTGFFAYTCG-RLVVVEDLHSG-AQQHWSGHSAEISTLALSHSAQVLASAS 1177
G +++ W D+ + + + D+ SG + GHS + + + ++ S S
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148
Query: 1178 GRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGT 1237
S +R+WDV G C + HS V A+ F+ D L+V+ +DG +W T
Sbjct: 149 FDES------VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS-SSYDG-LCRIWDT 200
Query: 1238 ATYDLVSSTRLPE--PVHGVAFNPWDAGELTCVGQGTVTFW 1276
A+ + + + PV V F+P L T+ W
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 33.5 bits (75), Expect = 1.9
Identities = 31/130 (23%), Positives = 50/130 (38%), Gaps = 11/130 (8%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GH +S +A S+LL SA +++WD +G+CL + + V +F+
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142
Query: 467 LLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQG 526
L+ D R V G+ + AH+D V A ++S G
Sbjct: 143 LIVSGSFDESVRIWDVK--------TGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYDG 193
Query: 527 SVRLWRLRGG 536
R+W G
Sbjct: 194 LCRIWDTASG 203
Score = 32.7 bits (73), Expect = 3.2
Identities = 21/82 (25%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 407 GHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGA 466
GH++ V + S+L+ S +R+WD +TG+CL + V ++ F+ G+
Sbjct: 127 GHSNYVFCCNFNPQSNLIVSGSF--DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 467 LLCGVGKDHHGRTMVVAWGTGQ 488
L+ V + G + +GQ
Sbjct: 185 LI--VSSSYDGLCRIWDTASGQ 204
Score = 32.7 bits (73), Expect = 3.2
Identities = 32/123 (26%), Positives = 45/123 (36%), Gaps = 5/123 (4%)
Query: 636 SEDGFLRLWPLDFSSVL--LEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYH 693
S DG R+W L L + PVS V SP+G +L+AT L D
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 694 MLARSHTAP---VLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTF 750
H + A + + S+D V IW+L T + + D +
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 751 HPT 753
HPT
Sbjct: 310 HPT 312
Score = 31.6 bits (70), Expect = 7.1
Identities = 31/134 (23%), Positives = 62/134 (46%), Gaps = 9/134 (6%)
Query: 861 MGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALG---HLLVSTSSNRVV-VLDAVS 916
+ S+S D+L+++ G D + S + A +LLVS S ++ + + D S
Sbjct: 60 LASSSADKLIKI-WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118
Query: 917 GRIIRELPGVHPEPCPSLTLSEDARFLLIAA-GRTIKVWDYATQASPGPQVYIGHSEPVQ 975
G+ ++ L G H + + ++ + ++++WD T + HS+PV
Sbjct: 119 GKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL--KTLPAHSDPVS 175
Query: 976 AVAFSPDQQQVLSA 989
AV F+ D ++S+
Sbjct: 176 AVHFNRDGSLIVSS 189
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 60.5 bits (145), Expect = 1e-08
Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 1110 LKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQH-WSGHSAEISTLALSH 1168
L+ V+G + + + P TG AY G +VV+ D QQH ++ +S LA S
Sbjct: 62 LEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSP 121
Query: 1169 SAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHD 1228
+ + + +R+WDV + H V +AFSP+ + +V++G
Sbjct: 122 DGKYIVTGENGHRPA----VRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQH 177
Query: 1229 GRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQ 1288
L +W +V+S ++ V ++F+ D+ VG V FW L ++S +
Sbjct: 178 DMVLNVWDWKKDIVVASNKVSCRVIALSFSE-DSSYFVTVGNRHVRFWFL-----EVSTE 231
Query: 1289 VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQ 1322
+ VG + + ++CG + G+
Sbjct: 232 TKVTSTVPLVGRSGILGELHNN---IFCGVACGR 262
Score = 34.7 bits (78), Expect = 0.84
Identities = 23/101 (22%), Positives = 48/101 (47%), Gaps = 4/101 (3%)
Query: 1435 RSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPE 1494
++ V + SP H A+ G++R+ L M+ +++ + + LCL +S P G
Sbjct: 492 KAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETG--- 548
Query: 1495 QQRLAAGYGDGSLRIFSVSRT-AMELKMHPHPVALTTVAFS 1534
LA+ D + + +V + +E + H ++T + F+
Sbjct: 549 LTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFA 589
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 60.5 bits (145), Expect = 1e-08
Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 14/214 (6%)
Query: 1110 LKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQH-WSGHSAEISTLALSH 1168
L+ V+G + + + P TG AY G +VV+ D QQH ++ +S LA S
Sbjct: 62 LEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSP 121
Query: 1169 SAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHD 1228
+ + + +R+WDV + H V +AFSP+ + +V++G
Sbjct: 122 DGKYIVTGENGHRPA----VRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQH 177
Query: 1229 GRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQ 1288
L +W +V+S ++ V ++F+ D+ VG V FW L ++S +
Sbjct: 178 DMVLNVWDWKKDIVVASNKVSCRVIALSFSE-DSSYFVTVGNRHVRFWFL-----EVSTE 231
Query: 1289 VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQ 1322
+ VG + + ++CG + G+
Sbjct: 232 TKVTSTVPLVGRSGILGELHNN---IFCGVACGR 262
Score = 34.7 bits (78), Expect = 0.84
Identities = 23/101 (22%), Positives = 48/101 (47%), Gaps = 4/101 (3%)
Query: 1435 RSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPE 1494
++ V + SP H A+ G++R+ L M+ +++ + + LCL +S P G
Sbjct: 492 KAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETG--- 548
Query: 1495 QQRLAAGYGDGSLRIFSVSRT-AMELKMHPHPVALTTVAFS 1534
LA+ D + + +V + +E + H ++T + F+
Sbjct: 549 LTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFA 589
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,321,377
Number of Sequences: 37866
Number of extensions: 3868814
Number of successful extensions: 16545
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 284
Number of HSP's that attempted gapping in prelim test: 12742
Number of HSP's gapped (non-prelim): 3301
length of query: 1748
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1632
effective length of database: 13,855,062
effective search space: 22611461184
effective search space used: 22611461184
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.