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Search of human proteins with 91992153
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens] 540 e-154
gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens] 540 e-154
gi|118442841 hypothetical protein LOC123591 [Homo sapiens] 82 4e-16
gi|40549435 transmembrane phosphatase with tensin homology isofo... 73 2e-13
gi|40549433 transmembrane phosphatase with tensin homology isofo... 65 8e-11
gi|109689707 transmembrane phosphatase with tensin homology isof... 64 1e-10
gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase... 62 5e-10
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 54 1e-07
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 53 2e-07
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 53 2e-07
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 53 2e-07
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 52 6e-07
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 52 6e-07
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 52 6e-07
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 52 6e-07
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 52 6e-07
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 50 3e-06
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 50 3e-06
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 50 3e-06
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 49 4e-06
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 47 2e-05
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 47 2e-05
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 47 2e-05
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 47 2e-05
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 47 2e-05
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 47 2e-05
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 46 4e-05
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 45 7e-05
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 45 7e-05
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 45 7e-05
>gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 540 bits (1390), Expect = e-154
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT 60
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT
Sbjct: 1 MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT 60
Query: 61 PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL 120
PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL
Sbjct: 61 PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL 120
Query: 121 ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV 180
ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV
Sbjct: 121 ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV 180
Query: 181 SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA 240
SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA
Sbjct: 181 SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA 240
Query: 241 KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 273
KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
Sbjct: 241 KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 273
>gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 540 bits (1390), Expect = e-154
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT 60
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT
Sbjct: 1 MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPT 60
Query: 61 PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL 120
PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL
Sbjct: 61 PVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAEL 120
Query: 121 ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV 180
ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV
Sbjct: 121 ILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVV 180
Query: 181 SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA 240
SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA
Sbjct: 181 SFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAA 240
Query: 241 KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 273
KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
Sbjct: 241 KIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN 273
>gi|118442841 hypothetical protein LOC123591 [Homo sapiens]
Length = 531
Score = 82.4 bits (202), Expect = 4e-16
Identities = 46/168 (27%), Positives = 90/168 (53%), Gaps = 4/168 (2%)
Query: 105 IICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRL- 163
++ V+L +L+ EL++D+K++Q A V H++S+ IL F E + ++ V +
Sbjct: 104 LVACVILVVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGIW 163
Query: 164 EFFHHKFEILDAVVVVVSF---ILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISV 220
++ +K E+ D V+++S + V ++A+ L+I+LR+WRV R+I+ ++ V
Sbjct: 164 DYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVIDAYVLPV 223
Query: 221 KTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGL 268
K E + + ++ V +++ L C E+ EI +L L Q L
Sbjct: 224 KLEMEMVIQQYEKAKVIQDEQLERLTQICQEQGFEIRQLRAHLAQQDL 271
>gi|40549435 transmembrane phosphatase with tensin homology isoform
gamma [Homo sapiens]
Length = 513
Score = 73.2 bits (178), Expect = 2e-13
Identities = 50/174 (28%), Positives = 87/174 (50%), Gaps = 25/174 (14%)
Query: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLF----SSHRFQVIIIC 107
E P PT ++G E G +P + G AP ++K+ SS F + +
Sbjct: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFGVF 62
Query: 108 LVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFV-FRLEFF 166
LV+LD L+LA+LI D Y + + +S+ I +FF+M+++ ++FV R ++F
Sbjct: 63 LVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYF 116
Query: 167 HHKFEILDAVVVVVSFILDIVLLFQE-----------HQFEALGLLILLRLWRV 209
F ILD ++V+ ++D+V +F + H L L+ILLR++ +
Sbjct: 117 SDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHL 170
>gi|40549433 transmembrane phosphatase with tensin homology isoform
beta [Homo sapiens]
Length = 533
Score = 64.7 bits (156), Expect = 8e-11
Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 45/194 (23%)
Query: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLD------------------------ 87
E P PT ++G E G +P + G AP
Sbjct: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSK 62
Query: 88 FRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITIL 147
+ ++ + SS F + + LV+LD L+LA+LI D Y + + +S+ I
Sbjct: 63 IKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIA 116
Query: 148 VFFMMEIIFKLFV-FRLEFFHHKFEILDAVVVVVSFILDIVLLFQE-----------HQF 195
+FF+M+++ ++FV R ++F F ILD ++V+ ++D+V +F + H
Sbjct: 117 LFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLL 176
Query: 196 EALGLLILLRLWRV 209
L L+ILLR++ +
Sbjct: 177 RLLRLIILLRIFHL 190
>gi|109689707 transmembrane phosphatase with tensin homology isoform
alpha [Homo sapiens]
Length = 551
Score = 64.3 bits (155), Expect = 1e-10
Identities = 38/131 (29%), Positives = 71/131 (54%), Gaps = 18/131 (13%)
Query: 91 MLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFF 150
++ + SS F + + LV+LD L+LA+LI D Y + + +S+ I +FF
Sbjct: 84 IVHSIVSSFAFGLFGVFLVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIALFF 137
Query: 151 MMEIIFKLFV-FRLEFFHHKFEILDAVVVVVSFILDIVLLFQE-----------HQFEAL 198
+M+++ ++FV R ++F F ILD ++V+ ++D+V +F + H L
Sbjct: 138 LMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLL 197
Query: 199 GLLILLRLWRV 209
L+ILLR++ +
Sbjct: 198 RLIILLRIFHL 208
>gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase
isoform gamma [Homo sapiens]
Length = 522
Score = 62.0 bits (149), Expect = 5e-10
Identities = 36/131 (27%), Positives = 71/131 (54%), Gaps = 18/131 (13%)
Query: 91 MLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFF 150
++ + SS F + + LV+LD L+LA+LI D Y + + +S+ I +FF
Sbjct: 66 IVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFT------DSKLYIPLEYRSISLAIGLFF 119
Query: 151 MMEIIFKLFVF-RLEFFHHKFEILDAVVVVVSFILDIVLLFQE-----------HQFEAL 198
+M+++ ++FV R ++F F ILD ++V+ ++D++ +F + H L
Sbjct: 120 LMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLL 179
Query: 199 GLLILLRLWRV 209
L+IL+R++ +
Sbjct: 180 RLIILIRIFHL 190
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/136 (26%), Positives = 71/136 (52%), Gaps = 10/136 (7%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR +G++ + +S F +III L++L+ + ++AE K ++ +
Sbjct: 1347 PIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKS--------IL 1398
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIV--LLFQEHQFEA 197
+++ +V F +E + K+F R +F + + + D VVV++S + ++ L QEH
Sbjct: 1399 DHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFP 1458
Query: 198 LGLLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1459 PTLFRIVRLARIGRIL 1474
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D+ Y +V
Sbjct: 1458 PIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--------DDQGKYMTLVL 1509
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1510 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1569
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1570 LFRVIRLARIGRIL 1583
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D+ Y +V
Sbjct: 1458 PIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--------DDQGKYMTLVL 1509
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1510 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1569
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1570 LFRVIRLARIGRIL 1583
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D+ Y +V
Sbjct: 1507 PIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--------DDQGKYMTLVL 1558
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1559 SRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPT 1618
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1619 LFRVIRLARIGRIL 1632
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 52.0 bits (123), Expect = 6e-07
Identities = 34/134 (25%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D++ Y +
Sbjct: 1511 PIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--------DDQSEYVTTIL 1562
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1563 SRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1622
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1623 LFRVIRLARIGRIL 1636
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 52.0 bits (123), Expect = 6e-07
Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D++ +
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVET--------DDQSQEMTNIL 1563
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1624 LFRVIRLARIGRIL 1637
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 52.0 bits (123), Expect = 6e-07
Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D++ +
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVET--------DDQSQEMTNIL 1563
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1624 LFRVIRLARIGRIL 1637
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 52.0 bits (123), Expect = 6e-07
Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR F+GM+ + F + I+ L+ L+ + ++ E D++ +
Sbjct: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVET--------DDQSQEMTNIL 1563
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++++ +V F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1624 LFRVIRLARIGRIL 1637
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 52.0 bits (123), Expect = 6e-07
Identities = 34/138 (24%), Positives = 69/138 (50%), Gaps = 16/138 (11%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR +G++ + F ++I+ L+ L+ + ++ E K ++ +
Sbjct: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMEN--------IL 1554
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVS----FILDIVLLFQEHQF 195
+++++ ++FF E + K+F R +F + I D VVV++S F+ DI+ E F
Sbjct: 1555 YWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADII----EKYF 1610
Query: 196 EALGLLILLRLWRVARII 213
+ L ++RL R+ RI+
Sbjct: 1611 VSPTLFRVIRLARIGRIL 1628
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 49.7 bits (117), Expect = 3e-06
Identities = 45/182 (24%), Positives = 76/182 (41%), Gaps = 26/182 (14%)
Query: 48 EEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDF--------RGMLRKLFSSH 99
EEEEEEEE P P R + ++ P P F R KL + H
Sbjct: 827 EEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHH 886
Query: 100 RFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKL- 158
F +I+ ++L + + AE + +++ + Y F +EI+ K+
Sbjct: 887 IFTNLILVFIMLSSAALAAEDPI-------RSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
Query: 159 ----FVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIIN 214
F+ + F + F +LD +VV VS + + Q A+ ++ +LR+ RV R +
Sbjct: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGI------QSSAISVVKILRVLRVLRPLR 993
Query: 215 GI 216
I
Sbjct: 994 AI 995
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 49.7 bits (117), Expect = 3e-06
Identities = 45/182 (24%), Positives = 76/182 (41%), Gaps = 26/182 (14%)
Query: 48 EEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDF--------RGMLRKLFSSH 99
EEEEEEEE P P R + ++ P P F R KL + H
Sbjct: 827 EEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHH 886
Query: 100 RFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKL- 158
F +I+ ++L + + AE + +++ + Y F +EI+ K+
Sbjct: 887 IFTNLILVFIMLSSAALAAEDPI-------RSHSFRNTILGYFDYAFTAIFTVEILLKMT 939
Query: 159 ----FVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIIN 214
F+ + F + F +LD +VV VS + + Q A+ ++ +LR+ RV R +
Sbjct: 940 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGI------QSSAISVVKILRVLRVLRPLR 993
Query: 215 GI 216
I
Sbjct: 994 AI 995
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 49.7 bits (117), Expect = 3e-06
Identities = 45/182 (24%), Positives = 76/182 (41%), Gaps = 26/182 (14%)
Query: 48 EEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDF--------RGMLRKLFSSH 99
EEEEEEEE P P R + ++ P P F R KL + H
Sbjct: 847 EEEEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHH 906
Query: 100 RFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKL- 158
F +I+ ++L + + AE + +++ + Y F +EI+ K+
Sbjct: 907 IFTNLILVFIMLSSAALAAEDPI-------RSHSFRNTILGYFDYAFTAIFTVEILLKMT 959
Query: 159 ----FVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIIN 214
F+ + F + F +LD +VV VS + + Q A+ ++ +LR+ RV R +
Sbjct: 960 TFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGI------QSSAISVVKILRVLRVLRPLR 1013
Query: 215 GI 216
I
Sbjct: 1014 AI 1015
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 49.3 bits (116), Expect = 4e-06
Identities = 31/134 (23%), Positives = 65/134 (48%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR +G + L ++ F + I+ L+ L+ + ++ E + ++ + V
Sbjct: 1485 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVE--------KEGQSQHMTEVL 1536
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
+++++ ++ F E + KL R +F + I D VVV++S + + E F +
Sbjct: 1537 YWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPT 1596
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1597 LFRVIRLARIGRIL 1610
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1455 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1509
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1510 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1566
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1567 LFRVIRLARIGRIL 1580
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1509 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1563
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1564 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1621 LFRVIRLARIGRIL 1634
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1508 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1562
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1563 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1619
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1620 LFRVIRLARIGRIL 1633
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1491 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1545
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1546 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1602
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1603 LFRVIRLARIGRIL 1616
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1509 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1563
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1564 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1620
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1621 LFRVIRLARIGRIL 1634
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 46.6 bits (109), Expect = 2e-05
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR ++G + + + F V I+ L+ L+ + ++ E P+K N A +
Sbjct: 1118 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQ----SPEKINILAKI- 1172
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALG 199
++ + F E I KL R +F + + I D VVV++S + ++ + F +
Sbjct: 1173 ---NLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229
Query: 200 LLILLRLWRVARII 213
L ++RL R+ RI+
Sbjct: 1230 LFRVIRLARIGRIL 1243
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 45.8 bits (107), Expect = 4e-05
Identities = 31/135 (22%), Positives = 67/135 (49%), Gaps = 10/135 (7%)
Query: 80 PAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVF 139
P PR +GM+ L + F + I+ L+ L+ + ++ E +++ +
Sbjct: 1334 PIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE--------TDNQSQLKVDIL 1385
Query: 140 HYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFI-LDIVLLFQEHQFEAL 198
+ +++ ++ F E + K+ R +F + I D VVV++S + L + L Q++ F +
Sbjct: 1386 YNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKY-FVSP 1444
Query: 199 GLLILLRLWRVARII 213
L ++RL R+ R++
Sbjct: 1445 TLFRVIRLARIGRVL 1459
Score = 30.0 bits (66), Expect = 2.3
Identities = 40/187 (21%), Positives = 76/187 (40%), Gaps = 26/187 (13%)
Query: 41 NYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLD---------FRGM 91
+YK E + EE+ EE P GE+ + P + R
Sbjct: 969 DYKPPEEDPEEQAEENP-----EGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRA 1023
Query: 92 LRKLFSSHRFQVIIICLVVLDA-LLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFF 150
K+ + F+ I+ +++L + L ++ ++ + + YA VF Y+ F
Sbjct: 1024 CFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYI-------F 1076
Query: 151 MMEIIFKLFVFRLE-FFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRV 209
+ME++ K + + +F + + LD ++V VS I L+ + LG + LR R
Sbjct: 1077 IMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSI---ISLVANWLGYSELGPIKSLRTLRA 1133
Query: 210 ARIINGI 216
R + +
Sbjct: 1134 LRPLRAL 1140
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 45.1 bits (105), Expect = 7e-05
Identities = 48/210 (22%), Positives = 82/210 (39%), Gaps = 24/210 (11%)
Query: 25 LRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPR- 83
L+ T G+ A IN + E E++ P P E+ V P P P
Sbjct: 806 LKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSEL 865
Query: 84 ------APLDFRGMLRKLFSSHRFQV---IIICLVVLDALLVLAELILDLKIIQPDKNNY 134
P+ S++RF++ I+ + L++ L+ + + D +
Sbjct: 866 HLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 135 AAM---VFHYMSITILVFFMMEIIFKL-----FVFRLEFFHHKFEILDAVVVVVSFILDI 186
+ + Y I F +EI K+ F+ + F + F ILD +VV VS I
Sbjct: 926 TSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG 985
Query: 187 VLLFQEHQFEALGLLILLRLWRVARIINGI 216
+ Q A+ ++ +LR+ RV R + I
Sbjct: 986 I------QSSAINVVKILRVLRVLRPLRAI 1009
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 45.1 bits (105), Expect = 7e-05
Identities = 50/210 (23%), Positives = 84/210 (40%), Gaps = 24/210 (11%)
Query: 25 LRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPR- 83
L+ T G+ A IN + E E++ P P E+ V P P P
Sbjct: 806 LKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSEL 865
Query: 84 ------APLDFRGMLRKLFSSHRFQV---IIICLVVLDALLVLAELILDLKIIQPDKNNY 134
P+ S++RF++ I+ + L++ L+ + + D +
Sbjct: 866 HLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 135 AAMVFHYMSITILVF---FMMEIIFKL-----FVFRLEFFHHKFEILDAVVVVVSFILDI 186
+ H + VF F +EII K+ F+ + F + F ILD +VV VS I
Sbjct: 926 TSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG 985
Query: 187 VLLFQEHQFEALGLLILLRLWRVARIINGI 216
+ Q A+ ++ +LR+ RV R + I
Sbjct: 986 I------QSSAINVVKILRVLRVLRPLRAI 1009
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 45.1 bits (105), Expect = 7e-05
Identities = 48/210 (22%), Positives = 82/210 (39%), Gaps = 24/210 (11%)
Query: 25 LRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPR- 83
L+ T G+ A IN + E E++ P P E+ V P P P
Sbjct: 806 LKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSEL 865
Query: 84 ------APLDFRGMLRKLFSSHRFQV---IIICLVVLDALLVLAELILDLKIIQPDKNNY 134
P+ S++RF++ I+ + L++ L+ + + D +
Sbjct: 866 HLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQH 925
Query: 135 AAM---VFHYMSITILVFFMMEIIFKL-----FVFRLEFFHHKFEILDAVVVVVSFILDI 186
+ + Y I F +EI K+ F+ + F + F ILD +VV VS I
Sbjct: 926 TSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFG 985
Query: 187 VLLFQEHQFEALGLLILLRLWRVARIINGI 216
+ Q A+ ++ +LR+ RV R + I
Sbjct: 986 I------QSSAINVVKILRVLRVLRPLRAI 1009
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.141 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,610,525
Number of Sequences: 37866
Number of extensions: 539659
Number of successful extensions: 12219
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 10879
Number of HSP's gapped (non-prelim): 1124
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.