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Search of human proteins with 90669307
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
(1395 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90669307 cyclin B3 isoform 3 [Homo sapiens] 2714 0.0
gi|16306525 cyclin B3 isoform 1 [Homo sapiens] 450 e-126
gi|14327896 cyclin B1 [Homo sapiens] 184 4e-46
gi|4757930 cyclin B2 [Homo sapiens] 165 2e-40
gi|161377472 cyclin A1 isoform c [Homo sapiens] 160 6e-39
gi|161377470 cyclin A1 isoform c [Homo sapiens] 160 6e-39
gi|161377468 cyclin A1 isoform b [Homo sapiens] 160 6e-39
gi|4502611 cyclin A1 isoform a [Homo sapiens] 160 6e-39
gi|4502613 cyclin A [Homo sapiens] 142 2e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 96 2e-19
gi|118572588 cyclin F [Homo sapiens] 90 1e-17
gi|153791755 cyclin domain containing [Homo sapiens] 86 2e-16
gi|221219020 NYD-SP11 protein [Homo sapiens] 84 1e-15
gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Ho... 81 6e-15
gi|17318559 cyclin E1 isoform 1 [Homo sapiens] 79 4e-14
gi|17318561 cyclin E1 isoform 2 [Homo sapiens] 79 4e-14
gi|17318565 cyclin E2 [Homo sapiens] 77 9e-14
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 76 3e-13
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 64 8e-10
gi|16950655 cyclin D1 [Homo sapiens] 64 1e-09
gi|45439327 periplakin [Homo sapiens] 61 7e-09
gi|87299628 biorientation of chromosomes in cell division 1-like... 61 9e-09
gi|16554449 zonadhesin isoform 3 [Homo sapiens] 61 9e-09
gi|27881494 zonadhesin isoform 6 [Homo sapiens] 61 9e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 60 1e-08
gi|210147567 hypothetical protein LOC220081 [Homo sapiens] 59 3e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 59 4e-08
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 58 6e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 57 9e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 1e-07
>gi|90669307 cyclin B3 isoform 3 [Homo sapiens]
Length = 1395
Score = 2714 bits (7036), Expect = 0.0
Identities = 1395/1395 (100%), Positives = 1395/1395 (100%)
Query: 1 MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR 60
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR
Sbjct: 1 MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR 60
Query: 61 SAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPV 120
SAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPV
Sbjct: 61 SAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPV 120
Query: 121 VASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKK 180
VASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKK
Sbjct: 121 VASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKK 180
Query: 181 CSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQR 240
CSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQR
Sbjct: 181 CSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQR 240
Query: 241 KQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFR 300
KQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFR
Sbjct: 241 KQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFR 300
Query: 301 KPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKED 360
KPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKED
Sbjct: 301 KPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKED 360
Query: 361 SLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSI 420
SLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSI
Sbjct: 361 SLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSI 420
Query: 421 KEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIE 480
KEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIE
Sbjct: 421 KEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIE 480
Query: 481 EAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ 540
EAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ
Sbjct: 481 EAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ 540
Query: 541 EMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSH 600
EMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSH
Sbjct: 541 EMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSH 600
Query: 601 LKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLA 660
LKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLA
Sbjct: 601 LKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLA 660
Query: 661 IQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTME 720
IQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTME
Sbjct: 661 IQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTME 720
Query: 721 EESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNK 780
EESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNK
Sbjct: 721 EESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNK 780
Query: 781 QPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTE 840
QPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTE
Sbjct: 781 QPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTE 840
Query: 841 KEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQE 900
KEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQE
Sbjct: 841 KEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQE 900
Query: 901 KPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKED 960
KPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKED
Sbjct: 901 KPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKED 960
Query: 961 TFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPT 1020
TFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPT
Sbjct: 961 TFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPT 1020
Query: 1021 TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVG 1080
TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVG
Sbjct: 1021 TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVG 1080
Query: 1081 KSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKER 1140
KSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKER
Sbjct: 1081 KSRTTTESSACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKER 1140
Query: 1141 EEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK 1200
EEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK
Sbjct: 1141 EEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKK 1200
Query: 1201 DKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPI 1260
DKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPI
Sbjct: 1201 DKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPI 1260
Query: 1261 AYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYW 1320
AYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYW
Sbjct: 1261 AYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYW 1320
Query: 1321 VPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKL 1380
VPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKL
Sbjct: 1321 VPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDMLKL 1380
Query: 1381 EEILNCDCEAQGLVL 1395
EEILNCDCEAQGLVL
Sbjct: 1381 EEILNCDCEAQGLVL 1395
>gi|16306525 cyclin B3 isoform 1 [Homo sapiens]
Length = 291
Score = 450 bits (1158), Expect = e-126
Identities = 223/223 (100%), Positives = 223/223 (100%)
Query: 1173 VSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYIC 1232
VSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYIC
Sbjct: 69 VSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYIC 128
Query: 1233 DDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQE 1292
DDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQE
Sbjct: 129 DDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQE 188
Query: 1293 YHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYD 1352
YHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYD
Sbjct: 189 YHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYD 248
Query: 1353 SLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL 1395
SLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL
Sbjct: 249 SLKAVYYKYSHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL 291
Score = 140 bits (352), Expect = 1e-32
Identities = 69/70 (98%), Positives = 69/70 (98%)
Query: 1 MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR 60
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR
Sbjct: 1 MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR 60
Query: 61 SAFEDLTNAS 70
SAFEDLTN S
Sbjct: 61 SAFEDLTNVS 70
>gi|14327896 cyclin B1 [Homo sapiens]
Length = 433
Score = 184 bits (468), Expect = 4e-46
Identities = 121/414 (29%), Positives = 211/414 (50%), Gaps = 26/414 (6%)
Query: 980 TAPESITSKSSIATMTSVGKSGT-INEAFLFEDMITLNEKPT-TGKELSFKEPLALQESP 1037
TAP + TSK + T++G G ++E + + KP+ TGK + K P L++ P
Sbjct: 29 TAPAA-TSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVP 87
Query: 1038 TCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTT----TESSACES 1093
E +P+ P E ++ + + S T+ E C++
Sbjct: 88 MLVPVPVSEP--VPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQA 145
Query: 1094 ASDKPVSPQAKGTPKEITPREDID-EDSSDPSFNPMYAKEIFSYMKE-REEQFILTDYMN 1151
SD I D+D ED +DP+ Y K+I++Y+++ EEQ + Y+
Sbjct: 146 FSDV------------ILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLL 193
Query: 1152 RQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAF 1211
+ E+T +MRAIL+DWLV+VQ+ F + ET+Y+ V ++D ++ K LQL+G TA
Sbjct: 194 GR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAM 252
Query: 1212 MIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARC 1271
IA+K+EE P + DF ++ D+ Y + ++ ME+ IL L + P+ HFLRR ++
Sbjct: 253 FIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKI 312
Query: 1272 IHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYS 1331
+++ TL++Y+ E+T+ +Y V S++AA + LAL + G W P L+HY Y+
Sbjct: 313 GEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYT 372
Query: 1332 ISELHPLVRQLNKLLTFSSYDSLK--AVYYKYSHPVFFEVAKIPALDMLKLEEI 1383
L P+++ L K + + K V KY+ +++ +P L+ ++++
Sbjct: 373 EESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDL 426
>gi|4757930 cyclin B2 [Homo sapiens]
Length = 398
Score = 165 bits (418), Expect = 2e-40
Identities = 117/397 (29%), Positives = 205/397 (51%), Gaps = 33/397 (8%)
Query: 1013 ITLNEKPTTGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSS 1072
+ L +PT +L E + + K + ++ +IG TT + K +
Sbjct: 1 MALLRRPTVSSDL---ENIDTGVNSKVKSHVTIRRTVLEEIGNRV----TTRAAQVAKKA 53
Query: 1073 IATMTSVGKSRTTTESSACE-SASDKPVSPQA---KG---TPKEITPRE----------- 1114
T V ++TT + + +AS KPV + KG TP++++ +E
Sbjct: 54 QNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDAL 113
Query: 1115 -----DID-EDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMNRQIEITSDMRAILVDWL 1168
DID ED +P Y K+I+ Y+++ E + + +I MRAILVDWL
Sbjct: 114 LCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWL 173
Query: 1169 VEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDF 1228
V+V F + ETLY+ V ++D +L + KLQL+G TA ++A+K+EE SP ++DF
Sbjct: 174 VQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDF 233
Query: 1229 VYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEM 1288
VYI D+ Y S++ ME IL LK ++ P+ HFLRR ++ +++ TL++Y+ E+
Sbjct: 234 VYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMEL 293
Query: 1289 TLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTF 1348
TL +Y V SK+AAA+ L+ + G W ++Y+GY+ +E+ +++ + K +
Sbjct: 294 TLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVK 353
Query: 1349 SSYDSLK--AVYYKYSHPVFFEVAKIPALDMLKLEEI 1383
+ + K A+ KY+ +++ IP L+ ++++
Sbjct: 354 VNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDL 390
>gi|161377472 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 160 bits (406), Expect = 6e-39
Identities = 94/254 (37%), Positives = 146/254 (57%), Gaps = 2/254 (0%)
Query: 1110 ITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFI-LTDYMNRQIEITSDMRAILVDWL 1168
++ EDI +D YA+EI+ Y++E E + YM +Q +IT MR ILVDWL
Sbjct: 148 LSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWL 207
Query: 1169 VEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDF 1228
VEV +++ ETLYLAV +D +L + KLQL+G A ++A+K+EE P VD+F
Sbjct: 208 VEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEF 267
Query: 1229 VYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEM 1288
VYI DD Y + ++L ME +L VL D+ +P FL +Y R ++T L++Y+ E+
Sbjct: 268 VYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAEL 327
Query: 1289 TLQEYH-YVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLT 1347
+L E +++ S +AAA+ LA Y +W L ++GYS+SE+ P + +L+K
Sbjct: 328 SLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYL 387
Query: 1348 FSSYDSLKAVYYKY 1361
+ +A+ KY
Sbjct: 388 DIPHRPQQAIREKY 401
>gi|161377470 cyclin A1 isoform c [Homo sapiens]
Length = 421
Score = 160 bits (406), Expect = 6e-39
Identities = 94/254 (37%), Positives = 146/254 (57%), Gaps = 2/254 (0%)
Query: 1110 ITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFI-LTDYMNRQIEITSDMRAILVDWL 1168
++ EDI +D YA+EI+ Y++E E + YM +Q +IT MR ILVDWL
Sbjct: 148 LSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWL 207
Query: 1169 VEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDF 1228
VEV +++ ETLYLAV +D +L + KLQL+G A ++A+K+EE P VD+F
Sbjct: 208 VEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEF 267
Query: 1229 VYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEM 1288
VYI DD Y + ++L ME +L VL D+ +P FL +Y R ++T L++Y+ E+
Sbjct: 268 VYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAEL 327
Query: 1289 TLQEYH-YVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLT 1347
+L E +++ S +AAA+ LA Y +W L ++GYS+SE+ P + +L+K
Sbjct: 328 SLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYL 387
Query: 1348 FSSYDSLKAVYYKY 1361
+ +A+ KY
Sbjct: 388 DIPHRPQQAIREKY 401
>gi|161377468 cyclin A1 isoform b [Homo sapiens]
Length = 464
Score = 160 bits (406), Expect = 6e-39
Identities = 94/254 (37%), Positives = 146/254 (57%), Gaps = 2/254 (0%)
Query: 1110 ITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFI-LTDYMNRQIEITSDMRAILVDWL 1168
++ EDI +D YA+EI+ Y++E E + YM +Q +IT MR ILVDWL
Sbjct: 191 LSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWL 250
Query: 1169 VEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDF 1228
VEV +++ ETLYLAV +D +L + KLQL+G A ++A+K+EE P VD+F
Sbjct: 251 VEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEF 310
Query: 1229 VYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEM 1288
VYI DD Y + ++L ME +L VL D+ +P FL +Y R ++T L++Y+ E+
Sbjct: 311 VYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAEL 370
Query: 1289 TLQEYH-YVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLT 1347
+L E +++ S +AAA+ LA Y +W L ++GYS+SE+ P + +L+K
Sbjct: 371 SLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYL 430
Query: 1348 FSSYDSLKAVYYKY 1361
+ +A+ KY
Sbjct: 431 DIPHRPQQAIREKY 444
>gi|4502611 cyclin A1 isoform a [Homo sapiens]
Length = 465
Score = 160 bits (406), Expect = 6e-39
Identities = 94/254 (37%), Positives = 146/254 (57%), Gaps = 2/254 (0%)
Query: 1110 ITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFI-LTDYMNRQIEITSDMRAILVDWL 1168
++ EDI +D YA+EI+ Y++E E + YM +Q +IT MR ILVDWL
Sbjct: 192 LSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWL 251
Query: 1169 VEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDF 1228
VEV +++ ETLYLAV +D +L + KLQL+G A ++A+K+EE P VD+F
Sbjct: 252 VEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEF 311
Query: 1229 VYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEM 1288
VYI DD Y + ++L ME +L VL D+ +P FL +Y R ++T L++Y+ E+
Sbjct: 312 VYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAEL 371
Query: 1289 TLQEYH-YVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLT 1347
+L E +++ S +AAA+ LA Y +W L ++GYS+SE+ P + +L+K
Sbjct: 372 SLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYL 431
Query: 1348 FSSYDSLKAVYYKY 1361
+ +A+ KY
Sbjct: 432 DIPHRPQQAIREKY 445
>gi|4502613 cyclin A [Homo sapiens]
Length = 432
Score = 142 bits (358), Expect = 2e-33
Identities = 93/270 (34%), Positives = 148/270 (54%), Gaps = 9/270 (3%)
Query: 1118 EDSSDPSFN--PMYAKEIFSYMKEREEQFI-LTDYMNRQIEITSDMRAILVDWLVEVQVS 1174
ED S N P Y ++I +Y++E E + YM +Q +IT+ MRAILVDWLVEV
Sbjct: 165 EDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE 224
Query: 1175 FEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDD 1234
+++ +ETL+LAV +D +L + KLQL+G A ++A+KFEE P V +FVYI DD
Sbjct: 225 YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDD 284
Query: 1235 NYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIH---TNMKTLTLSRYICEMTLQ 1291
Y + +VL ME +L VL D+ P FL +Y +H N K +L+ ++ E++L
Sbjct: 285 TYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQY--FLHQQPANCKVESLAMFLGELSLI 342
Query: 1292 EYH-YVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSS 1350
+ Y++ S +A A+ LALY W L +GY++ L P + L++ +
Sbjct: 343 DADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAP 402
Query: 1351 YDSLKAVYYKYSHPVFFEVAKIPALDMLKL 1380
+ +++ KY + + V+ + + L L
Sbjct: 403 QHAQQSIREKYKNSKYHGVSLLNPPETLNL 432
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 95.9 bits (237), Expect = 2e-19
Identities = 215/1000 (21%), Positives = 397/1000 (39%), Gaps = 208/1000 (20%)
Query: 177 SLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMT------FKKTHKTEEAAITKKTLS 230
+++K S E +SL ++L +++E V++ M K K E + +K
Sbjct: 443 TIEKTSEEERISLQQELSRVKQE-------VVDVMKKSSEEQIAKLQKLHEKELARKEQE 495
Query: 231 LKKKMCASQRK---------QSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTH 281
L KK+ +R+ + Q E L + +++S +E + +KK ES +
Sbjct: 496 LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES--EN 553
Query: 282 KLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQE----KH 337
KL L+++ Y +T I SS++K E + ++L+V E KH
Sbjct: 554 KLRDLQQEAETY------------RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601
Query: 338 TTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSR 397
E + + K L+ ++D+L E L K+ E L+E+C E K +
Sbjct: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK----LREKCEQE-KETL 656
Query: 398 LKP--LVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPS-ALQKKHTTQEEVSILKEP 454
LK ++ Q ++ L +K+ TE ES S E S L+ +H +EE+S+LK+
Sbjct: 657 LKDKEIIFQAHIEEMNEKTLEKLDVKQ---TELESLSSELSEVLKARHKLEEELSVLKDQ 713
Query: 455 SSLLKSPTEESPFDE-----------------ALAFTKKCTIEEAPPTKKPLILKRKHA- 496
+ +K E ++ ++ T+K ++ + L + KH
Sbjct: 714 TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773
Query: 497 ---------------TQGTMSHLKKPLIL----------QTTSGEKSLIK---EPLPFKE 528
++G + L + QT + E+ L + + L +
Sbjct: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833
Query: 529 EKVSLKKKCTTQEMMS--ICPEL-------------LDFQDMIGEDKNSFFMEPMSFRKN 573
E++ L K+ E +C EL L+ Q+ E K + +
Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Query: 574 PTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVL-QKITSEEESFY-------------- 618
+E TK L +E I Q + K+ +L QK++++E+S +
Sbjct: 894 DGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE 953
Query: 619 KKLLPFK-----MKSTTEEKFLSQEPSALKEKHTTLQEVSLSKE---------------- 657
KK+ K M+ T ++K L QE KE T E+S ++
Sbjct: 954 KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 658 -SLAIQEKATTEEEFSQELFSLHVKHTNKSGSLF-----QEALVLQEKTDAE-EDSLKNL 710
S A+ T ++E + L +H + N S++ Q+A LQE + + ++ + +
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEV 1073
Query: 711 LALQEKSTM---EEESLINKLLALKEELSAEAATNIQTQLSLKKKST---------SHGK 758
L++K + E+E + ++ LKEE + T + Q LK+KS + K
Sbjct: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133
Query: 759 VFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKE 818
K ++ LN+++ E FL +Q + L K+LA +++ + E K
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVEL--------------KMLAEEDKRKV-SELTSKL 1178
Query: 819 PTIDTE------AHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEK------- 865
T D E +H K +L E+ S E + + +E ++ + K+T AL E
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSL-EDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237
Query: 866 -PSIEQEALFKRHSALWEKPSTEKETIFKESLDLQE-KPSIKKETLLKKPLALKMSTINE 923
S + A+ R S + + KE + ++ + E + +++ T + L +
Sbjct: 1238 ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
Query: 924 AV-----LFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVS 978
+ + M A E T KE KE Q++ + KE T L ++ + N
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI--TQLKKELSENINAV 1355
Query: 979 STAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEK 1018
+ E + K ++S+ K T L ++ I+L+EK
Sbjct: 1356 TLMKEELKEKK--VEISSLSKQLTDLNVQL-QNSISLSEK 1392
Score = 56.2 bits (134), Expect = 2e-07
Identities = 185/867 (21%), Positives = 335/867 (38%), Gaps = 145/867 (16%)
Query: 89 VSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILD-----ISTTS 143
+ K+++ N +A+ L K+ LK K+E++ + T + ++ + L IS+
Sbjct: 1344 LKKELSENINAVTLMKEE---LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLR 1400
Query: 144 KTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVS-LLEKLQPLQEESDS 202
K + E+ L + ++D + +LS +K S E+V K ++++ S
Sbjct: 1401 KQYDEEKCELLDQ---------VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS 1451
Query: 203 ---DDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQ-SCQEESLAVQDVNMEE 258
++ + + K++EA + ++L K+ Q K+ C + ME+
Sbjct: 1452 RFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE-------MED 1504
Query: 259 DSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKK 318
D ME KK+ E + + ++ + I K + K
Sbjct: 1505 DKSKME----KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 319 PTTEKETLFQELSVLQEKHTTEHEMSIL--KKSLALQKTNFKEDSLVKESLAFKKKPSTE 376
+K FQEL ++ E E IL + + K + E + K E
Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 377 EAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPS 436
E + L+ + + K + LK Q+I + +K L+ + ++EK K+ S
Sbjct: 1621 ELKALEDRLESE--SAAKLAELKRKAEQKIAAIKKQLLSQ---MEEKEEQYKKGTESHLS 1675
Query: 437 ALQKKHTTQE-EVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKH 495
L K +E EV IL+E ++S E+ A E+ + + K
Sbjct: 1676 ELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK--- 1732
Query: 496 ATQGTMSHLKKPLILQTTSGEKS-LIKEPLPFKEEKVS--LKKKCTTQEMMSICPELL-- 550
++ +K +LQ EK L++ KEE VS + +C QE +
Sbjct: 1733 ------TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 551 --DFQDMIG------EDKNSFF-------MEPMSFRKNPTTE---ETVLTKTSLSLQEKK 592
+ Q MIG E+KN + +E + N + E V +LQEK+
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 593 IT----QGKMSHLKKPLVLQKITSEEE-----SFYKKLLPFK-----------MKSTTEE 632
+T + K+ L LV QK E S Y+KL + ++ TEE
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 633 KFLSQ--EPSALKEKHTTLQEVSLSKESLAIQEKATTEEEF---SQELFSLHVKHTNKSG 687
K S +P L ++ K + A +EK +E ++L L +H
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEF-KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ---- 1961
Query: 688 SLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQL 747
QE +L+++ D E + EK E+E L K + ++L E TQL
Sbjct: 1962 ---QELEILKKEYDQERE---------EKIKQEQEDLELKHNSTLKQLMRE----FNTQL 2005
Query: 748 SLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEE 807
+ K++ ++ + ETIN+ + + + LE + E L KK+
Sbjct: 2006 AQKEQEL----------EMTIKETINKAQEVEAE--LLESHQE--ETNQLLKKIA----- 2046
Query: 808 PSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPS 867
EK+ LK T ++E L +EE T K L+ + + +++ L +E P
Sbjct: 2047 ---EKDDDLKR----TAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG 2099
Query: 868 IEQEALFKRHSALWEKPSTEKETIFKE 894
+ + + + L +K + ++ KE
Sbjct: 2100 NDNVTIMELQTQLAQKTTLISDSKLKE 2126
Score = 31.6 bits (70), Expect = 5.6
Identities = 81/400 (20%), Positives = 154/400 (38%), Gaps = 32/400 (8%)
Query: 580 VLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFY-----KKLLPFKMKSTTEEK- 633
++T + +EKK QG +S + L++I E KK L + ++ EEK
Sbjct: 160 LVTAYQMLQREKKKLQGILSQ-SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKD 218
Query: 634 ----FLSQEPSALKEK-HTTLQEVSLSKE--SLAIQEKATTEEEFSQELFSLHVKHTNKS 686
L + S LK++ V + K L Q + T+EE + + +
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES----DGEPVVED 274
Query: 687 GSLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQ 746
G+ + LQ++ +E+ LK K T++ LL ++E +Q Q
Sbjct: 275 GTSVKTLETLQQRVKRQENLLKRC-----KETIQSHKEQCTLLTSEKEA-------LQEQ 322
Query: 747 LSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQE 806
L + + K + ++ L + + + L +Q L + IAE + + L M+E
Sbjct: 323 LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ-LEQDKGMVIAETKRQMHETLEMKE 381
Query: 807 EPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKP 866
E + + +K+ T E ++ + E E L EA K + E+
Sbjct: 382 EEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI 441
Query: 867 SIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAVL 926
++ + +L ++ S K+ + E+ K + L +K LA K + + +
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 501
Query: 927 FEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTL 966
+ E+ E S E L + + +E L+ L
Sbjct: 502 TRER-EFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
>gi|118572588 cyclin F [Homo sapiens]
Length = 786
Score = 90.1 bits (222), Expect = 1e-17
Identities = 56/190 (29%), Positives = 96/190 (50%), Gaps = 1/190 (0%)
Query: 1156 ITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAA 1215
+ MR IL+DWLVEV + T L+L V+ VD YL + + + +LQLLG +I
Sbjct: 305 LNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACMVICT 364
Query: 1216 KFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTN 1275
+F + + V++ D+ Y+ +++ M I++ L+ I +P + +
Sbjct: 365 RFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTLVPVE 424
Query: 1276 MKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLA-LYMKKLGYWVPFLEHYSGYSISE 1334
++T L ++CE++L ++LAAA+LLLA L + W L +G+S +
Sbjct: 425 LRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGFSYED 484
Query: 1335 LHPLVRQLNK 1344
L P V L+K
Sbjct: 485 LIPCVLSLHK 494
>gi|153791755 cyclin domain containing [Homo sapiens]
Length = 350
Score = 85.9 bits (211), Expect = 2e-16
Identities = 51/191 (26%), Positives = 91/191 (47%), Gaps = 8/191 (4%)
Query: 1129 YAKEIFSYMKEREEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKL 1188
Y + +++ K +E F + + RQ ++T++ R L+ WL+ V F ++ E+L L V
Sbjct: 101 YGQSCYAFRKAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNT 160
Query: 1189 VDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINI 1248
+D +L D QLLG T+ +IA K E + PRV + +C + R ++ ++E +
Sbjct: 161 LDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIV 220
Query: 1249 LNVLKCDINIPIAYHFLRRYARC--------IHTNMKTLTLSRYICEMTLQEYHYVQEKA 1300
L+ L + P FL + ++ L+R + E++L +Y +
Sbjct: 221 LHKLHFTLGAPTISFFLEHFTHARVEAGQAEASEALEAQALARGVAELSLADYAFTSYSP 280
Query: 1301 SKLAAASLLLA 1311
S LA L LA
Sbjct: 281 SLLAICCLALA 291
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 83.6 bits (205), Expect = 1e-15
Identities = 186/864 (21%), Positives = 348/864 (40%), Gaps = 134/864 (15%)
Query: 149 EEASLFRKPLVLK-EEPTIEDETLINKSLSLKKCSNH-----EEVSLLEKLQPLQEESDS 202
E+ + RK L K E+ E+E L K L + N EE+ E+ QE+ +
Sbjct: 1656 EKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELA 1715
Query: 203 DDA----FVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNM-- 256
+ + +E +++K+ +E K + KKK+ + + Q E L+ ++ +
Sbjct: 1716 QELEELEWDMEELSWKEEELNQEEG---KLVEEKKKLAEEEEALAWQREKLSEEETKLAQ 1772
Query: 257 EEDSFFMESMSF----KKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGA 312
EE+ E +K P+ EE + + ++KK + K +
Sbjct: 1773 EEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERW------------- 1819
Query: 313 MSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKK 372
++S+++ T K L+Q+ ++ QEK E K+ LA +K N + KE L KK
Sbjct: 1820 INSMEELTKNKMILYQKKNLAQEKKNLAQE----KEKLAQRKENLLYN---KERLTHSKK 1872
Query: 373 PSTEEAIMMPVILKEQCMTEGKRSRLKPLVL---QEITSGEKSLIMKPLSI---KEKPST 426
+ + + K E K ++ K V+ +++ EK L+ S+ +EK +
Sbjct: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQ 1932
Query: 427 EKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTK 486
EK + E + +Q K + E+ I KE ++AL K EE
Sbjct: 1933 EKMKLALEKAMVQGKKRLRGELDIAKE--------------EKALNLEMKRLAEE----- 1973
Query: 487 KPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSIC 546
K +++ K T+S + P TS ++ + + E K+SL++K E +
Sbjct: 1974 KMRLVEGKE----TLSKGETP----ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILA 2025
Query: 547 PELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLV 606
E + I + K F F V + L+ +K+ + + S K+P
Sbjct: 2026 ME----ESEIAKGKLEFTRGQRIF---------VQGQRKLAKASRKLIKKRESLSKEPAK 2072
Query: 607 LQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSAL--KEKHTTLQEVSLSKESLAIQEK 664
L KI +KL + K T EE +++ AL KE+ ++++ L + EK
Sbjct: 2073 LNKILKA----LQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEK 2128
Query: 665 ATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKN-----LLALQEKSTM 719
+ + ++L K NK + + +EK EE L +L +E+ +
Sbjct: 2129 RSELTKDEKKLARKQRKLANKMRRMINK----EEKMTEEESKLARKHSEVILDDEEEGGI 2184
Query: 720 EEESLINKLLAL-KEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFL 778
EEE +I L ++ A+ + + S + + F + + L+E +E
Sbjct: 2185 EEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLS 2244
Query: 779 NKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPS 838
+++ E E E +++ +EE E+E K+ + E K+ ++E
Sbjct: 2245 SEEEEERE-----EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEV 2299
Query: 839 TEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKE---S 895
EKE V +E +E ++ +E S+ E + +L E+ EKE + KE
Sbjct: 2300 QEKEEVFEEK--------EEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFK 2351
Query: 896 LDLQEKPSIK-KETLLK--------KPLALKMSTINEAVLFEDMIALNEKPTTGKELSFK 946
L Q + S++ +E +L K A+++ + L + +T E+ K
Sbjct: 2352 LQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKS--------PLKKLMSTALEMKEK 2403
Query: 947 EPLALQESPTYKEDTFLKTLLVPQ 970
P+ + E ED + +P+
Sbjct: 2404 TPVPVPEKQISWEDKKATVVEIPR 2427
Score = 68.6 bits (166), Expect = 4e-11
Identities = 181/856 (21%), Positives = 330/856 (38%), Gaps = 204/856 (23%)
Query: 169 ETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEE---AAIT 225
E +++ ++ + EEV+L E++ EE + + +T ++ H EE A I
Sbjct: 1526 ENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE-------QQVTEEQRHIQEEHKWARIH 1578
Query: 226 KKTLSLKKKMCASQRKQSCQEESLAVQD--------------VNMEEDSFFMESMSFKKK 271
+K +KK +RK + +EE LA ++ V + +D M K
Sbjct: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Query: 272 PKTEE--------SIPTHKLSSLKKKCTI-YGKICHFRKPPVLQTTICGAMSSIKK---- 318
K E S KL+ +KK + K+ + + G ++ +K
Sbjct: 1639 QKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKG---GKLAEVKNILAQ 1695
Query: 319 -----PTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKP 373
P E+ +QE + QE E +M L S ++ N +E LV+E KK
Sbjct: 1696 KVEELPQREQNLDWQEKELAQELEELEWDMEEL--SWKEEELNQEEGKLVEEK---KKLA 1750
Query: 374 STEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQ 433
EEA+ ++ E K ++ + L++QE KEK + KE +
Sbjct: 1751 EEEEALAWQ--REKLSEEETKLAQEEELLIQE---------------KEKLAQHKEKMPE 1793
Query: 434 EPSALQKKHTT--QEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLIL 491
E L +K ++++ + ++ + S EE ++ + + KK +E KK L
Sbjct: 1794 EEERLGRKREQLIEKKMKLAQKRERWINS-MEELTKNKMILYQKKNLAQE----KKNLAQ 1848
Query: 492 KRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLD 551
+++ Q KE L + +E+++ KK +++ + +L
Sbjct: 1849 EKEKLAQR---------------------KENLLYNKERLTHSKK----QLVQVKNKLGM 1883
Query: 552 FQDMIGEDKNSFFMEPMSFRKNP-----TTEETVLTKTSLSLQEKKITQGKMSHLKKPLV 606
F ++ + + E + K T ++ V + SL+ +++K+ Q KM L
Sbjct: 1884 FNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMK-----LA 1938
Query: 607 LQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKAT 666
L+K + KK L ++ EEK L+ E L E+ L E KE+L+ K
Sbjct: 1939 LEKAMVQG----KKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE---GKETLS---KGE 1988
Query: 667 TEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQE----------- 715
T E Q K T LF+ L L+EK ED +LA++E
Sbjct: 1989 TPETSRQR------KMTQVEQELFERKLSLEEKILLHED---RILAMEESEIAKGKLEFT 2039
Query: 716 ------------------------KSTMEEESLINKLLALKEELSAEAATNIQTQLSLKK 751
+S +E + +NK+L ++L+ + Q ++ + K
Sbjct: 2040 RGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK 2099
Query: 752 KSTSHGKVFFLKKQLALNET---INEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEP 808
+ +F +++L++ ++ I E +F K+ + +A + +KL
Sbjct: 2100 MKRA---LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQ---RKLANKMRRM 2153
Query: 809 SIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVL----------------------- 845
++E + +E + H + L +EE E+E V+
Sbjct: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
Query: 846 --KEPSVDTEAHFKE-------TLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESL 896
+ V++E HF E L QE S E+E + E+ E+E KE
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
Query: 897 DLQEKPSIKKETLLKK 912
+ +EK K+E KK
Sbjct: 2274 EGEEKQVEKEEEEKKK 2289
Score = 40.0 bits (92), Expect = 0.016
Identities = 127/611 (20%), Positives = 228/611 (37%), Gaps = 89/611 (14%)
Query: 137 LDISTTSKTPNTEEASLFRKPLVLKE--EPTIEDETLINKSLSLKKCSNHEEVSLLEKLQ 194
LDI+ K N E L + + L E E + ET S ++ E L E+
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGET---PETSRQRKMTQVEQELFERKL 2010
Query: 195 PLQEES--DSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQ 252
L+E+ D +E K K E + + ++K+ + RK + ESL+ +
Sbjct: 2011 SLEEKILLHEDRILAMEESEIAKG-KLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKE 2069
Query: 253 DVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFR--KPPVLQTTIC 310
+ + ++ ++ ++ T+E I K++ +K+ + + K + +
Sbjct: 2070 PAKLNKILKALQKLTRDERKLTQEEI---KMTKMKRALFVKERRLSIEQSKLDIKEWDFS 2126
Query: 311 GAMSSIKKPTTEKETLFQELS------VLQEKHTTEHEMSILKKSLALQKTNFKEDSLVK 364
S + K + ++L+ + +E+ TE E + +K + + +E + +
Sbjct: 2127 EKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
Query: 365 ES-LAFKK-------------KPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGE 410
E + F K KP + + + + E+ +E S L L QE S E
Sbjct: 2187 EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSE 2246
Query: 411 KSLIMKPLS------IKEKPSTEKESFSQEPSALQK-------------KHTTQEEVSIL 451
+ + ++E+ KE E ++K K QE+ +
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVF 2306
Query: 452 KEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKH---ATQGTMSHLKKPL 508
+E ++ ES DE + C++EE +K ++ K K Q S +
Sbjct: 2307 EEKEEIMSEEETESLSDEEEE-EESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
Query: 509 ILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ-EMMSICPELLDFQDMIGEDKNSFFME- 566
+L G + K LKK +T EM P + + + EDK + +E
Sbjct: 2366 VLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEI 2425
Query: 567 PMSFRKNPTTEETVLTK----------TSLSLQEKKITQGKMSHLKKPLVLQKITSEEES 616
P F E V+ K T L Q + + MSH +L++ EE
Sbjct: 2426 PRKFLGTMDKEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSH-----ILRRTVEAEEL 2480
Query: 617 FYKKL---------LPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLA--IQEKA 665
+K L P M T + LSQ P+ KE+H +VSLS + E+
Sbjct: 2481 QHKPLGAWWKWFLQHPPLMGQTEVQLPLSQIPA--KEQHA---DVSLSDVEWIRHVLERM 2535
Query: 666 TTEEEFSQELF 676
E+ S++ F
Sbjct: 2536 EAGEQLSRDGF 2546
>gi|242247025 cyclin N-terminal domain containing 2 isoform 2 [Homo
sapiens]
Length = 307
Score = 81.3 bits (199), Expect = 6e-15
Identities = 52/156 (33%), Positives = 81/156 (51%)
Query: 1156 ITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAA 1215
+T +MRA++VDWLV+V + +TLYLAV L+D YL + +LQLLG +A
Sbjct: 103 VTPEMRALVVDWLVQVHEYLGLAGDTLYLAVHLLDSYLSAGRVRLHRLQLLGVACLFVAC 162
Query: 1216 KFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTN 1275
K EE P + D++ R+E+L E IL+ L ++ P L A ++
Sbjct: 163 KMEECVLPEPAFLCLLSADSFSRAELLRAERRILSRLDFRLHHPGPLLCLGLLAALAGSS 222
Query: 1276 MKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLA 1311
+ + L+ Y E++L E + + AAA+L LA
Sbjct: 223 PQVMLLATYFLELSLLEAEAAGWEPGRRAAAALSLA 258
>gi|17318559 cyclin E1 isoform 1 [Homo sapiens]
Length = 410
Score = 78.6 bits (192), Expect = 4e-14
Identities = 57/203 (28%), Positives = 98/203 (48%), Gaps = 7/203 (3%)
Query: 1092 ESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMN 1151
+ D V P + P+ I P S P + +E++ M +E+ ++ +
Sbjct: 79 DKEDDDRVYPNSTCKPRIIAP----SRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFL 134
Query: 1152 RQIEITSD-MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLGAT 1209
Q + MRAIL+DWL+EV +++ ET YLA D Y+ + K LQL+G +
Sbjct: 135 EQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGIS 194
Query: 1210 AFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYA 1269
+ IAAK EE P++ F Y+ D E+L+ME+ I+ LK ++ +L Y
Sbjct: 195 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM 254
Query: 1270 RCIHTN-MKTLTLSRYICEMTLQ 1291
+ + N + + L +Y ++ +Q
Sbjct: 255 QVAYLNDLHEVLLPQYPQQIFIQ 277
>gi|17318561 cyclin E1 isoform 2 [Homo sapiens]
Length = 395
Score = 78.6 bits (192), Expect = 4e-14
Identities = 57/203 (28%), Positives = 98/203 (48%), Gaps = 7/203 (3%)
Query: 1092 ESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFILTDYMN 1151
+ D V P + P+ I P S P + +E++ M +E+ ++ +
Sbjct: 64 DKEDDDRVYPNSTCKPRIIAP----SRGSPLPVLSWANREEVWKIMLNKEKTYLRDQHFL 119
Query: 1152 RQIEITSD-MRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLM-KAVCKKDKLQLLGAT 1209
Q + MRAIL+DWL+EV +++ ET YLA D Y+ + K LQL+G +
Sbjct: 120 EQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQLIGIS 179
Query: 1210 AFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYA 1269
+ IAAK EE P++ F Y+ D E+L+ME+ I+ LK ++ +L Y
Sbjct: 180 SLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM 239
Query: 1270 RCIHTN-MKTLTLSRYICEMTLQ 1291
+ + N + + L +Y ++ +Q
Sbjct: 240 QVAYLNDLHEVLLPQYPQQIFIQ 262
>gi|17318565 cyclin E2 [Homo sapiens]
Length = 404
Score = 77.4 bits (189), Expect = 9e-14
Identities = 41/129 (31%), Positives = 75/129 (58%), Gaps = 2/129 (1%)
Query: 1130 AKEIFSYMKEREEQFILTDYMN-RQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKL 1188
+KE++ M ++E +++ + ++ MR+IL+DWL+EV + + ET YLA
Sbjct: 110 SKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDF 169
Query: 1189 VDLYLM-KAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEIN 1247
D +++ + K+ LQL+G T+ IA+K EE +P++ +F Y+ D ++L ME+
Sbjct: 170 FDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELI 229
Query: 1248 ILNVLKCDI 1256
IL LK ++
Sbjct: 230 ILKALKWEL 238
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 75.9 bits (185), Expect = 3e-13
Identities = 166/813 (20%), Positives = 329/813 (40%), Gaps = 83/813 (10%)
Query: 152 SLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPM 211
S +K ++ K+E + + ++ S K +H+ +L + L+EE +DA
Sbjct: 350 SSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHRELRE 409
Query: 212 TFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESM---SF 268
+K K + I +KK ++ ++SC E+S+ + + E S E + S
Sbjct: 410 AQEKELKLCKTQIQDMEKEMKK--LRAELRKSCTEQSVISR--TLREKSKVEEKLQEDSR 465
Query: 269 KKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQ 328
+K + +E + + + + G++ HFR V++ T A KP T+++ + +
Sbjct: 466 RKLLQLQEMGNRESVIKINLERAV-GQLEHFRSQ-VIKATYGRAKPFRDKPVTDQQLIEK 523
Query: 329 ELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESL--------AFKKKPSTEEAIM 380
V ++ + + L+K L + +E + E L A K +
Sbjct: 524 ITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLK 583
Query: 381 MPVILKEQCMTEGKRSRLKPLVLQEITSG-----EKSLIMKPLSIKEKPSTEKESFSQEP 435
V L + S L+ +VL + E +++ L I PS+ + Q+
Sbjct: 584 KEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGIL--PSSPNKDQVQQF 641
Query: 436 SALQKKHTTQEEVSILKEPSSL----------LKSPTEESPFDEALAFTKKCTIEEAPPT 485
S T + +S + + E ++ +E
Sbjct: 642 SGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRA 701
Query: 486 KKPLILKRKHATQ--GTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVS-LKKKCTTQEM 542
K+ L +RK + ++ KK L T EK+ +KE L ++ +V L+++ Q+
Sbjct: 702 KETLEEERKRMQELESLLAQQKKALAKSITQ-EKNRVKEALEEEQTRVQELEERLARQKE 760
Query: 543 M---SICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMS 599
+ SI E ++ + +K + +N T++ +++++++ +++K +
Sbjct: 761 VLESSIAHEKRKAKEALESEKRK-----VQDLENHLTQQKEISESNIAYEKRKAKEAMEK 815
Query: 600 HLKKPLVLQ-KITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKES 658
KK L+ ++T ++E K + K LS + ++E T SL ES
Sbjct: 816 EKKKVQDLENRLTKQKEELELK----EQKEDVLNNKLSDALAMVEETQKTKATESLKAES 871
Query: 659 LAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKST 718
LA++ T E ++ T + +E L+LQ+K + ALQ++
Sbjct: 872 LALKLNETLAE----------LETTKTKMIMVEERLILQQKM---------VKALQDEQE 912
Query: 719 MEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFL 778
+ +++ KE++ A T + + L+K + H K+ L N+ +EE
Sbjct: 913 SQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEE-R 971
Query: 779 NKQPLALEGYPSIAEG---ETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQE 835
+ PL S A+ E L LLA Q+E ++E ++K TEAH + L+
Sbjct: 972 PQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMS-DLRG 1030
Query: 836 EPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKES 895
E + +++ L++ V + KE L+EK + S+L EK E + + +
Sbjct: 1031 ELNEKQKMELEQNVVLVQQQSKELSVLKEK--------MAQMSSLVEKKDRELKALEEAL 1082
Query: 896 LDLQEKPSIKKETLLKKPLALKMSTINEAVLFE 928
QEK ++ T ++ K T + +V E
Sbjct: 1083 RASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIE 1115
Score = 40.4 bits (93), Expect = 0.012
Identities = 105/492 (21%), Positives = 192/492 (39%), Gaps = 52/492 (10%)
Query: 632 EKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQ 691
E++++QE + KE TL+E E + QEL SL L Q
Sbjct: 691 EEYITQERNRAKE---TLEE----------------ERKRMQELESL----------LAQ 721
Query: 692 EALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLKK 751
+ L + E++ +K AL+E+ T +E L +L KE L + A + + + +
Sbjct: 722 QKKALAKSITQEKNRVKE--ALEEEQTRVQE-LEERLARQKEVLESSIAH--EKRKAKEA 776
Query: 752 KSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEG-ETLFKKLLAMQEEPSI 810
+ KV L+ L + I+E ++ A E + + L +L +EE +
Sbjct: 777 LESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELEL 836
Query: 811 --EKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAV---LKEPSVDTEAHFKETLALQEK 865
+KE VL D A +E + S + E++ L E + E + + ++E+
Sbjct: 837 KEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEER 896
Query: 866 PSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAV 925
++Q K AL ++ +++ +E ++ +E+ +T++ L+ T +
Sbjct: 897 LILQQ----KMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKK 952
Query: 926 LFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESI 985
+ ++ L + KE ++PL + + +D + L+ + + S +
Sbjct: 953 IEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIM 1012
Query: 986 TSKSSIATMTS--VGKSGTINEAFLFEDMITLNEKPTTGKELS-FKEPLALQESPTCKED 1042
+ + S G +NE E + KELS KE +A S K+D
Sbjct: 1013 KLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKD 1072
Query: 1043 ---TFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTE--SSACESASDK 1097
LE L +T E K + TSV TE SS+ E S
Sbjct: 1073 RELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFS 1132
Query: 1098 PVSPQAKGTPKE 1109
+ + KG+ E
Sbjct: 1133 DLGVRCKGSRHE 1144
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 64.3 bits (155), Expect = 8e-10
Identities = 99/392 (25%), Positives = 167/392 (42%), Gaps = 53/392 (13%)
Query: 578 ETVLTKTSLSLQEKKITQG--KMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFL 635
E L+ T L +E + K+S L + L K+ + +L K ++
Sbjct: 719 ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL--DLNRLVAQLEEEKSALQGRQRQA 776
Query: 636 SQEPSALKEKHTTLQEVSLSKE--------SLAIQEKATTEEEFSQELFSLHVKHTNKSG 687
QE + +E+ L+E+ L +E SL + E+A +E Q+L +L + +
Sbjct: 777 EQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQA--QEALEQQLPTLRHERSQLQE 834
Query: 688 SLFQEALVL----QEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSA-----E 738
L Q + L QE A ++ + + AL E++ E+E+L + L +L A
Sbjct: 835 QLAQLSRQLSGREQELEQARREAQRQVEAL-ERAAREKEALAKEHAGLAVQLVAAEREGR 893
Query: 739 AATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLF 798
+ T+L L+K++ G +F +++QLA E E+ Q L L E L
Sbjct: 894 TLSEEATRLRLEKEALE-GSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLR 952
Query: 799 KKLLAMQEEPSIEKEAV---LKEPTIDTEAHFKEPLALQEEP----STEKEAVLKEPSVD 851
++++A QE+ S++KE + L + + +A +E A EE EKEA +E
Sbjct: 953 QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA- 1011
Query: 852 TEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLL- 910
E LQ + EQE L R A EKE + +E LQ++ + E LL
Sbjct: 1012 ------ERAQLQSQLQREQEELLARLEA-------EKEELSEEIAALQQE---RDEGLLL 1055
Query: 911 ---KKPLALKMSTINEAVLFEDMIALNEKPTT 939
+K AL + + L E ++ T
Sbjct: 1056 AESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
Score = 36.6 bits (83), Expect = 0.17
Identities = 106/540 (19%), Positives = 218/540 (40%), Gaps = 72/540 (13%)
Query: 326 LFQELSVLQ-EKHTTEHEMSILKKSLALQKTNFKEDSLVKESL--AFKKKPSTEEAI--M 380
L +E S LQ + E E ++ ++ + E + ++ L + + +EA+
Sbjct: 762 LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQ 821
Query: 381 MPVILKEQCMTEGKRSRLKPLVL---QEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSA 437
+P + E+ + + ++L + QE+ + + + E+ + EKE+ ++E +
Sbjct: 822 LPTLRHERSQLQEQLAQLSRQLSGREQELEQARREA-QRQVEALERAAREKEALAKEHAG 880
Query: 438 LQKKHTTQE-EVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHA 496
L + E E L E ++ L+ E E F + + + ++ L
Sbjct: 881 LAVQLVAAEREGRTLSEEATRLRLEKEAL---EGSLFEVQRQLAQLEARREQL------E 931
Query: 497 TQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMI 556
+G L K +T +GE + +++ + +EK SL K+ Q+++ E
Sbjct: 932 AEGQALLLAK----ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE-------- 979
Query: 557 GEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEES 616
S R+ E L + LQ +K + ++ + ++ E+E
Sbjct: 980 ---------AQASLREQRAAHEEDLQR----LQREKEAAWRELEAERAQLQSQLQREQEE 1026
Query: 617 FYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELF 676
+L E++ LS+E +AL+++ ++ S++ A+ K + + S++L
Sbjct: 1027 LLARL-------EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL- 1078
Query: 677 SLHVKHTNKSGSLFQEALVLQEKTDAEED---------SLKNLLALQEKSTMEEESLINK 727
+ +H+ + SL E ++ E+D L++L A +E++ + +
Sbjct: 1079 -MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR 1137
Query: 728 L------LALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQ 781
L L + + A ++TQL L + + + L+ Q L E+ E ++
Sbjct: 1138 LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE 1197
Query: 782 PLALEGYPSIAEGETLFKKLLAMQEE-PSIEKEAVLKEPTIDTEAHFKE-PLALQEEPST 839
A E S+ EG + L EE S K+A + ++ KE LAL EE T
Sbjct: 1198 --AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART 1255
>gi|16950655 cyclin D1 [Homo sapiens]
Length = 295
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/179 (25%), Positives = 80/179 (44%), Gaps = 4/179 (2%)
Query: 1153 QIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFM 1212
Q E+ MR I+ W++EV + E LA+ +D +L KK +LQLLGAT
Sbjct: 49 QKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMF 108
Query: 1213 IAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAY----HFLRRY 1268
+A+K +E + D++ + E+L ME+ ++N LK ++ + HFL +
Sbjct: 109 VASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKM 168
Query: 1269 ARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHY 1327
++ + + ++ S +AA S++ A+ L FL +Y
Sbjct: 169 PEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYY 227
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 61.2 bits (147), Expect = 7e-09
Identities = 127/613 (20%), Positives = 256/613 (41%), Gaps = 46/613 (7%)
Query: 317 KKPTTEKETLFQEL--SVLQEKHTTE---HEMSILK---KSLALQKTNFKEDSLVKESLA 368
K P E FQ+L ++ +E+H + E+ L+ ++L + + ++ +VKE L
Sbjct: 940 KVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLR 999
Query: 369 FKK-KPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITS--GEKSLIMKPLSIKEKPS 425
+ + +E + + L+ +G R L+ Q + + EKS + ++ KE
Sbjct: 1000 IEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK 1059
Query: 426 TEKE-SFSQEPSALQKKHTTQEEVSILKEPS-SLLKSPTEESPFDEALAFTKKCTIEEAP 483
+ + E LQ+ H Q+++ +E S L+ + + A+A K T++E
Sbjct: 1060 LQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA-EGKITVKEVL 1118
Query: 484 PTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKS-LIKEPLPFKEEKVSLKKKCTTQEM 542
+K +R+ + T + + + + EK+ L+++ +EE + + +E+
Sbjct: 1119 KVEKDAATERE-VSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREI 1177
Query: 543 MSICP----ELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKM 598
+ P E+ + + + E + + R + E L + ++ K++T+ +
Sbjct: 1178 VRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEA-LRRRGPQVEVKEVTKEVI 1236
Query: 599 SHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKES 658
+ P + +++ E K + + E L +E ALK+ +Q + +E
Sbjct: 1237 KYKTDPEMEKELQRLREEIVDKTRLIE-RCDLEIYQLKKEIQALKDTKPQVQTKEVVQEI 1295
Query: 659 LAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSL---KNLLALQE 715
L QE T+EE + L + K L +E +E+ +E+ L K + QE
Sbjct: 1296 LQFQEDPQTKEEVASLRAKLS-EEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQE 1354
Query: 716 KSTMEEE-SLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQL-------- 766
EEE L + A E + E + + L++ + L++QL
Sbjct: 1355 VVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTE---LERQLEELERERQ 1411
Query: 767 ALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAH 826
A E E + L ++ ALE + A + + + +Q++P +E L ++ E H
Sbjct: 1412 ARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQH 1471
Query: 827 FKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPST 886
++ L + E K A L+ +A KE + L E +E+ + L K S
Sbjct: 1472 RRQLLEGELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRL--KSSL 1523
Query: 887 EKETIFKESLDLQ 899
E+E+ K LD++
Sbjct: 1524 EEESRSKRELDVE 1536
Score = 55.1 bits (131), Expect = 5e-07
Identities = 89/355 (25%), Positives = 145/355 (40%), Gaps = 40/355 (11%)
Query: 631 EEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLF 690
E L Q +AL E+ + QE KE + +Q E E+ Q+L H +
Sbjct: 1030 EVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEY-QQLQEDHQRQDQLREKQE 1088
Query: 691 QEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLK 750
+E LQ+K E K + K T++E + K A + E+S T + K
Sbjct: 1089 EELSFLQDKLKRLE---KERAMAEGKITVKEVLKVEKDAATEREVSD--LTRQYEDEAAK 1143
Query: 751 KKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSI 810
+++ K L+K AL E N + + ++ + AE E +L +++E
Sbjct: 1144 ARASQREKTELLRKIWALEEE-NAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKY 1202
Query: 811 ------------EKEAVLKE-PTIDTEAHFKEPLALQEEPSTEKEAV-LKEPSVDTEAHF 856
E EA+ + P ++ + KE + + +P EKE L+E VD
Sbjct: 1203 RGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR-- 1260
Query: 857 KETLALQEKPSIEQEALFKRHSALWE-KPSTEKETIFKESLDLQEKPSIKKETL-----L 910
L E+ +E L K AL + KP + + + +E L QE P K+E L
Sbjct: 1261 -----LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKL 1315
Query: 911 KKPLALKMSTINEAVLFEDMIALNEKPTTGKELS-FKEPLALQESPTYKEDTFLK 964
+ ++ E E+ IA E +ELS KE + QE Y+E+ L+
Sbjct: 1316 SEEQKKQVDLERERASQEEQIARKE-----EELSRVKERVVQQEVVRYEEEPGLR 1365
Score = 41.6 bits (96), Expect = 0.005
Identities = 60/321 (18%), Positives = 136/321 (42%), Gaps = 49/321 (15%)
Query: 146 PNTEEASLFRKPLVLKEEPTIEDET------LINKSLSLKKCSNHEEVSLLEKLQPLQEE 199
P E + ++ + K +P +E E +++K+ +++C + E L +++Q L++
Sbjct: 1224 PQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERC-DLEIYQLKKEIQALKDT 1282
Query: 200 SDSDDA--FVIEPMTFKKTHKTEE--AAITKKTLSLKKKMCASQRKQSCQEESLAVQDVN 255
V E + F++ +T+E A++ K +KK +R+++ QEE +A ++
Sbjct: 1283 KPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKE-- 1340
Query: 256 MEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSS 315
+LS +K++ + ++ + + P L+ S
Sbjct: 1341 -------------------------EELSRVKER-VVQQEVVRYEEEPGLRAEASAFAES 1374
Query: 316 IKKPTTEKETLFQELSVLQEKHT-TEHEMSILKKSLALQKTNFKEDSLVKESLAF---KK 371
I + + L EL LQ + T E ++ L++ ++ +E +++ LA ++
Sbjct: 1375 IDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEE 1434
Query: 372 KPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQE------ITSGEKSLIMKPLSIKEKPS 425
+ E+ ++ +Q + + L L L+E + GE + + L+ EK
Sbjct: 1435 AEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE 1494
Query: 426 TEKESFSQEPSALQKKHTTQE 446
+++ E ++K T QE
Sbjct: 1495 VKEKVVLSESVQVEKGDTEQE 1515
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 60.8 bits (146), Expect = 9e-09
Identities = 219/1056 (20%), Positives = 391/1056 (37%), Gaps = 194/1056 (18%)
Query: 28 DPSEKTGEN-CQTKISPSSLQESPSSLQGALKKRSAF--------EDLTNASQCQPVQPK 78
D EK +N +T+ S SS ++ S + K + ++LT + Q + +
Sbjct: 441 DDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKE 500
Query: 79 KEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILD 138
KE +++ ++INR L +K K+ + K T ++V D
Sbjct: 501 KEE-----RLLRRQINREK----LEEKRKQKAEKTKSSKTKGQGRSSV-----------D 540
Query: 139 ISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQE 198
+ +S +A+ ++ VLKE +E + ++K K N EE S +K Q +E
Sbjct: 541 LEESSTKSLEPKAARIKE--VLKERKVLEKKVALSKKRK-KDSRNVEENS--KKKQQYEE 595
Query: 199 ESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQ-----EESLAVQD 253
+S K+T KT E +K S K+ + + + ESL V D
Sbjct: 596 DS-------------KETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVD 642
Query: 254 VNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAM 313
N E E P E + + K+ +IC
Sbjct: 643 ENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEIC---------------- 686
Query: 314 SSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKP 373
++P +K TL E + ++ T H S+LKK + K + ++K
Sbjct: 687 --TEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPE-----------REKT 733
Query: 374 STEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQ 433
+E+ + + K CM + E+ S EK L K +K S + + S
Sbjct: 734 PSEDKLSVKHKYKGDCMHKTGDET-------ELHSSEKGL--KVEENIQKQSQQTKLSSD 784
Query: 434 EPSALQKKHTTQEEVSILKE---PSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLI 490
+ + + KH + ++S+L + P S T+E+ E ++ + E+ K
Sbjct: 785 DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRR 844
Query: 491 LKRKHATQGTMSHLKKPLILQ--------------TTSGEKSLIKEPLPFKE-------- 528
+ ++ + + LQ +T+ + +L E + KE
Sbjct: 845 SSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLL 904
Query: 529 -EKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLS 587
EK+ LK K TQ ++++ + G K + +P K TEE K S
Sbjct: 905 EEKLVLKSKSKTQGKQV---KVVETELQEGATKQATTPKP---DKEKNTEENDSEKQRKS 958
Query: 588 LQEKK-------------------ITQGKMSHLKK-PLVLQKITSEEESFYKKLLPFKMK 627
E K TQ SH K PL +K S+++S +L K+
Sbjct: 959 KVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL-ERKLS 1017
Query: 628 STTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSG 687
+ + L +K+K + KE + EKA ++ S + N+ G
Sbjct: 1018 DGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCE-NRRG 1076
Query: 688 SLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQL 747
SL QE +EK A S + +LQ + +LI + +E + ++ ++
Sbjct: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPE----QEPMEIDSEPGVENVF 1132
Query: 748 SLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGE----TLFKKLLA 803
+ K N N ++ ++ + + + ++ + E T K A
Sbjct: 1133 EVSKTQD--------------NRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATA 1178
Query: 804 MQEEP--------SIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLK---EPSVDT 852
+P + EK A + T+ + H + A+ + EKE + + E ++D+
Sbjct: 1179 PAYKPGRGTGVNSNSEKHADHRS-TLTKKMHIQS--AVSKMNPGEKEPIHRGTTEVNIDS 1235
Query: 853 EAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKK 912
E + L+ + Q+ L K +A E+ + + + S +L PS+ T++
Sbjct: 1236 ETVHRMLLSAPSENDRVQKNL-KNTAA--EEHVAQGDATLEHSTNLDSSPSLSSVTVVP- 1291
Query: 913 PLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVG 972
L+ S + + D + E T + L Q S T +E LKT + G
Sbjct: 1292 ---LRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQ-SLTVRESEVLKTSDSKEGG 1347
Query: 973 TSPNVSSTAPESITSKSSI-----ATMTSVGKSGTI 1003
V + A SITSK I AT+ GK G +
Sbjct: 1348 EGFTVDTPAKASITSKRHIPEAHQATLLD-GKQGKV 1382
Score = 36.2 bits (82), Expect = 0.23
Identities = 114/540 (21%), Positives = 216/540 (40%), Gaps = 62/540 (11%)
Query: 446 EEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLK 505
E ++ L + +S ++ TE S + +KK + T K T M+ +
Sbjct: 206 ETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTD-----KERTSEDMADKE 260
Query: 506 KPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPE-----LL--DFQDMIGE 558
K SG + L E P EE L C +E+ + E LL D Q E
Sbjct: 261 KST---ADSGGEGL--ETAPKSEEFSDLP--CPVEEIKNYTKEHNNLILLNKDVQQESSE 313
Query: 559 DKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFY 618
KN K P + E K ++K+ T+ K H KK QK+ E+++
Sbjct: 314 QKNK---STDKGEKKPDSNE----KGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKE 366
Query: 619 KKLLPFKM---KSTTEEKFL---SQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFS 672
K++ K+ K++ + K + ++ S + L ++++S S+ + ++ EE+
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVS--SVHTSDLSSFEEDTE 424
Query: 673 QELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTME-EESLINKLLAL 731
+E+ + S S+ + + +D EE + +N Q + E + +
Sbjct: 425 EEVVT--------SDSMEEGEIT----SDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVH 472
Query: 732 KEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSI 791
K L ++ ++ +L+++++ S K K++ L IN E+ K+ E S
Sbjct: 473 KPYLYSKYYSDSDDELTVEQRRQSIAKE---KEERLLRRQINREKLEEKRKQKAEKTKSS 529
Query: 792 -AEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLK--EP 848
+G+ L S+E +A + + ++ +AL ++ + V + +
Sbjct: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589
Query: 849 SVDTEAHFKETLALQEKPSIEQEALFK--RHSALWEKPSTEKETIFKESLDLQEKPSIKK 906
E KETL E E+ + K +H +PS + ESL + ++ K
Sbjct: 590 KQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRL-SESLHVVDEN--KN 646
Query: 907 ETLLKKPLALKMST--INEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLK 964
E+ L++ + ST I E V E ++ E+ +EP ++ T K + LK
Sbjct: 647 ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEP--QKQKSTLKNEKHLK 704
>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
Length = 2812
Score = 60.8 bits (146), Expect = 9e-09
Identities = 92/308 (29%), Positives = 130/308 (42%), Gaps = 48/308 (15%)
Query: 806 EEPSI--EKEAVLKE-PTIDTEAHFKEPLALQEEP--STEKEAV-LKEPSVDTEAHFKET 859
E+P+I EK +L E PTI +E +P E+P STEK V +EP+ TE ET
Sbjct: 617 EKPTIPSEKPTILTEKPTIPSE----KPTIPSEKPTISTEKPTVPTEEPTTPTE----ET 668
Query: 860 LALQEKPSIEQEALFKRHSALWEKPS--TEKETI-FKESLDLQEKPSIKKETLLKKPLAL 916
E+P I E + S EKPS TEK TI +E++ EKP+I E KP
Sbjct: 669 TTSMEEPVIPTE----KPSIPTEKPSIPTEKPTISMEETIISTEKPTISPE----KPT-- 718
Query: 917 KMSTINEAVLFEDMIALNEKPTTGKE---LSFKEPLALQESPTYKEDTFLKTLLVPQVGT 973
+ T + E EKPTT E + ++P E PT + K + P+ T
Sbjct: 719 -IPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTE---KPTISPEKLT 774
Query: 974 SPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEPLAL 1033
P T P T K +I T T E+ EKP+ E K L
Sbjct: 775 IPTEKPTIP---TEKPTIPTEKPT--ISTEEPTTPTEETTISTEKPSIPME---KPTLPT 826
Query: 1034 QESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTESSACES 1093
+E+ T E+T + T + P + + P TEK +I+ + T +
Sbjct: 827 EETTTSVEETTISTEKLTIPMEKPTISTEKPTIPTEKPTIS------PEKLTIPTEKLTI 880
Query: 1094 ASDKPVSP 1101
++KP P
Sbjct: 881 PTEKPTIP 888
Score = 56.6 bits (135), Expect = 2e-07
Identities = 134/554 (24%), Positives = 217/554 (39%), Gaps = 112/554 (20%)
Query: 116 EVTPVVASTTVVPN----IMEKPLILDISTTSKTPNTEEASLF-RKPLVLKEEPTIEDET 170
E+ PV ++ P+ + E P I ST T + E+ S+ KP V KE+PTI E
Sbjct: 541 ELPPVSPVSSTGPSETTGLTENPTI---STKKPTVSIEKPSVTTEKPTVPKEKPTIPTE- 596
Query: 171 LINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAIT--KKT 228
K + E+ ++ + + E + + +T K T +E+ I K T
Sbjct: 597 --------KPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPT 648
Query: 229 LSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKK 288
+S +K ++ + EE+ +MEE P + SIPT K S +
Sbjct: 649 ISTEKPTVPTEEPTTPTEETTT----SMEEPVI----------PTEKPSIPTEKPSIPTE 694
Query: 289 KCTIYGK--ICHFRKPPVLQTTICGAMSSIKKPT--TEKETLFQELSVLQ-EKHTTEHEM 343
K TI + I KP + S +KPT TEK T+ E S + EK TT E
Sbjct: 695 KPTISMEETIISTEKPTI----------SPEKPTIPTEKPTIPTEKSTISPEKPTTPTE- 743
Query: 344 SILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVL 403
K ++ +K + K + +K + E + +P K TE KP +
Sbjct: 744 ---KPTIPTEKPTISPE---KPTTPTEKPTISPEKLTIPTE-KPTIPTE------KPTIP 790
Query: 404 QEITSGEKSLIMKPLSIKEKPSTEKESFS---QEPSALQKKHTTQEEVSILKEPSSLLKS 460
E KP E+P+T E + ++PS +K T E + + + +
Sbjct: 791 TE----------KPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEETTIST 840
Query: 461 PTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLI 520
P ++ T+K TI PT P + L + T
Sbjct: 841 EKLTIPMEKPTISTEKPTIPTEKPTISP-----------------EKLTIPTEKLTIPTE 883
Query: 521 KEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPT--TEE 578
K +P +E +S +K E +I PE + I +K P + PT TEE
Sbjct: 884 KPTIPIEETTISTEKLTIPTEKPTISPE----KPTISTEK------PTIPTEKPTIPTEE 933
Query: 579 TVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEK--FLS 636
T ++ L++ +K T +S K + +K T E K +P + + EK +
Sbjct: 934 TTISTEKLTIPTEKPT---ISPEKLTIPTEKPTISTE---KPTIPTEKLTIPTEKPTIPT 987
Query: 637 QEPSALKEKHTTLQ 650
++P+ EK T L+
Sbjct: 988 EKPTIPTEKLTALR 1001
Score = 48.1 bits (113), Expect = 6e-05
Identities = 134/560 (23%), Positives = 215/560 (38%), Gaps = 94/560 (16%)
Query: 460 SPTEESPFDEALAFTKKCTIEEAPPTKKPLI-LKRKHATQGTMSHLKKPLILQTTSGEKS 518
SP + E T+ TI TKKP + +++ T + K+ + T S
Sbjct: 546 SPVSSTGPSETTGLTENPTIS----TKKPTVSIEKPSVTTEKPTVPKEKPTIPTEKPTIS 601
Query: 519 LIKEPLPFKEEKVSLKKKCTTQEMMSIC---PELLDFQDMIGEDKNSFFMEPMSFRKNPT 575
K +P ++ + +K E +I P + + I +K + E + PT
Sbjct: 602 TEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPTISTEKPTV---PT 658
Query: 576 TEETVLTK-TSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKST---TE 631
E T T+ T+ S++E I K S I +E+ S + M+ T TE
Sbjct: 659 EEPTTPTEETTTSMEEPVIPTEKPS----------IPTEKPSIPTEKPTISMEETIISTE 708
Query: 632 EKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQ 691
+ +S E + + T+ +++S EK TT T K +
Sbjct: 709 KPTISPEKPTIPTEKPTIP----TEKSTISPEKPTTP--------------TEKPTIPTE 750
Query: 692 EALVLQEK----TDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQL 747
+ + EK T+ S + L EK T+ E + K +S E T +
Sbjct: 751 KPTISPEKPTTPTEKPTISPEKLTIPTEKPTIPTEK--PTIPTEKPTISTEEPTTPTEET 808
Query: 748 SLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEE 807
++ ST + K L ET S+ E +KL E+
Sbjct: 809 TI---STEKPSIPMEKPTLPTEETTT----------------SVEETTISTEKLTIPMEK 849
Query: 808 PSIEKEAVLKEPTIDTEAHFKEP--LALQEEP---STEKEAV-LKEPSVDTEAHF----K 857
P+I E +PTI TE P L + E TEK + ++E ++ TE K
Sbjct: 850 PTISTE----KPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEK 905
Query: 858 ETLALQEKPSIEQEALFKRHSALWEKPS--TEKETIFKESLDLQ-EKPSIKKETLLKKPL 914
T++ EKP+I E + + EKP+ TE+ TI E L + EKP+I E L
Sbjct: 906 PTIS-PEKPTISTE----KPTIPTEKPTIPTEETTISTEKLTIPTEKPTISPEKLTIPTE 960
Query: 915 ALKMSTINEAVLFEDMIALNEKPTTGKE---LSFKEPLALQESPTYKEDTFLKTLLV-PQ 970
+ST + E + EKPT E + ++ AL+ T L L++ P
Sbjct: 961 KPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTATGLAALVMSPH 1020
Query: 971 VGTSPNVSSTAPESITSKSS 990
++P S + TS+SS
Sbjct: 1021 APSTPMTSVILGTTTTSRSS 1040
>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
Length = 2721
Score = 60.8 bits (146), Expect = 9e-09
Identities = 92/308 (29%), Positives = 130/308 (42%), Gaps = 48/308 (15%)
Query: 806 EEPSI--EKEAVLKE-PTIDTEAHFKEPLALQEEP--STEKEAV-LKEPSVDTEAHFKET 859
E+P+I EK +L E PTI +E +P E+P STEK V +EP+ TE ET
Sbjct: 617 EKPTIPSEKPTILTEKPTIPSE----KPTIPSEKPTISTEKPTVPTEEPTTPTE----ET 668
Query: 860 LALQEKPSIEQEALFKRHSALWEKPS--TEKETI-FKESLDLQEKPSIKKETLLKKPLAL 916
E+P I E + S EKPS TEK TI +E++ EKP+I E KP
Sbjct: 669 TTSMEEPVIPTE----KPSIPTEKPSIPTEKPTISMEETIISTEKPTISPE----KPT-- 718
Query: 917 KMSTINEAVLFEDMIALNEKPTTGKE---LSFKEPLALQESPTYKEDTFLKTLLVPQVGT 973
+ T + E EKPTT E + ++P E PT + K + P+ T
Sbjct: 719 -IPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTE---KPTISPEKLT 774
Query: 974 SPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEPLAL 1033
P T P T K +I T T E+ EKP+ E K L
Sbjct: 775 IPTEKPTIP---TEKPTIPTEKPT--ISTEEPTTPTEETTISTEKPSIPME---KPTLPT 826
Query: 1034 QESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTESSACES 1093
+E+ T E+T + T + P + + P TEK +I+ + T +
Sbjct: 827 EETTTSVEETTISTEKLTIPMEKPTISTEKPTIPTEKPTIS------PEKLTIPTEKLTI 880
Query: 1094 ASDKPVSP 1101
++KP P
Sbjct: 881 PTEKPTIP 888
Score = 56.6 bits (135), Expect = 2e-07
Identities = 134/554 (24%), Positives = 217/554 (39%), Gaps = 112/554 (20%)
Query: 116 EVTPVVASTTVVPN----IMEKPLILDISTTSKTPNTEEASLF-RKPLVLKEEPTIEDET 170
E+ PV ++ P+ + E P I ST T + E+ S+ KP V KE+PTI E
Sbjct: 541 ELPPVSPVSSTGPSETTGLTENPTI---STKKPTVSIEKPSVTTEKPTVPKEKPTIPTE- 596
Query: 171 LINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAIT--KKT 228
K + E+ ++ + + E + + +T K T +E+ I K T
Sbjct: 597 --------KPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPT 648
Query: 229 LSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKK 288
+S +K ++ + EE+ +MEE P + SIPT K S +
Sbjct: 649 ISTEKPTVPTEEPTTPTEETTT----SMEEPVI----------PTEKPSIPTEKPSIPTE 694
Query: 289 KCTIYGK--ICHFRKPPVLQTTICGAMSSIKKPT--TEKETLFQELSVLQ-EKHTTEHEM 343
K TI + I KP + S +KPT TEK T+ E S + EK TT E
Sbjct: 695 KPTISMEETIISTEKPTI----------SPEKPTIPTEKPTIPTEKSTISPEKPTTPTE- 743
Query: 344 SILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVL 403
K ++ +K + K + +K + E + +P K TE KP +
Sbjct: 744 ---KPTIPTEKPTISPE---KPTTPTEKPTISPEKLTIPTE-KPTIPTE------KPTIP 790
Query: 404 QEITSGEKSLIMKPLSIKEKPSTEKESFS---QEPSALQKKHTTQEEVSILKEPSSLLKS 460
E KP E+P+T E + ++PS +K T E + + + +
Sbjct: 791 TE----------KPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEETTIST 840
Query: 461 PTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLI 520
P ++ T+K TI PT P + L + T
Sbjct: 841 EKLTIPMEKPTISTEKPTIPTEKPTISP-----------------EKLTIPTEKLTIPTE 883
Query: 521 KEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPT--TEE 578
K +P +E +S +K E +I PE + I +K P + PT TEE
Sbjct: 884 KPTIPIEETTISTEKLTIPTEKPTISPE----KPTISTEK------PTIPTEKPTIPTEE 933
Query: 579 TVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEK--FLS 636
T ++ L++ +K T +S K + +K T E K +P + + EK +
Sbjct: 934 TTISTEKLTIPTEKPT---ISPEKLTIPTEKPTISTE---KPTIPTEKLTIPTEKPTIPT 987
Query: 637 QEPSALKEKHTTLQ 650
++P+ EK T L+
Sbjct: 988 EKPTIPTEKLTALR 1001
Score = 48.1 bits (113), Expect = 6e-05
Identities = 134/560 (23%), Positives = 215/560 (38%), Gaps = 94/560 (16%)
Query: 460 SPTEESPFDEALAFTKKCTIEEAPPTKKPLI-LKRKHATQGTMSHLKKPLILQTTSGEKS 518
SP + E T+ TI TKKP + +++ T + K+ + T S
Sbjct: 546 SPVSSTGPSETTGLTENPTIS----TKKPTVSIEKPSVTTEKPTVPKEKPTIPTEKPTIS 601
Query: 519 LIKEPLPFKEEKVSLKKKCTTQEMMSIC---PELLDFQDMIGEDKNSFFMEPMSFRKNPT 575
K +P ++ + +K E +I P + + I +K + E + PT
Sbjct: 602 TEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPTISTEKPTV---PT 658
Query: 576 TEETVLTK-TSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKST---TE 631
E T T+ T+ S++E I K S I +E+ S + M+ T TE
Sbjct: 659 EEPTTPTEETTTSMEEPVIPTEKPS----------IPTEKPSIPTEKPTISMEETIISTE 708
Query: 632 EKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQ 691
+ +S E + + T+ +++S EK TT T K +
Sbjct: 709 KPTISPEKPTIPTEKPTIP----TEKSTISPEKPTTP--------------TEKPTIPTE 750
Query: 692 EALVLQEK----TDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQL 747
+ + EK T+ S + L EK T+ E + K +S E T +
Sbjct: 751 KPTISPEKPTTPTEKPTISPEKLTIPTEKPTIPTEK--PTIPTEKPTISTEEPTTPTEET 808
Query: 748 SLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEE 807
++ ST + K L ET S+ E +KL E+
Sbjct: 809 TI---STEKPSIPMEKPTLPTEETTT----------------SVEETTISTEKLTIPMEK 849
Query: 808 PSIEKEAVLKEPTIDTEAHFKEP--LALQEEP---STEKEAV-LKEPSVDTEAHF----K 857
P+I E +PTI TE P L + E TEK + ++E ++ TE K
Sbjct: 850 PTISTE----KPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEK 905
Query: 858 ETLALQEKPSIEQEALFKRHSALWEKPS--TEKETIFKESLDLQ-EKPSIKKETLLKKPL 914
T++ EKP+I E + + EKP+ TE+ TI E L + EKP+I E L
Sbjct: 906 PTIS-PEKPTISTE----KPTIPTEKPTIPTEETTISTEKLTIPTEKPTISPEKLTIPTE 960
Query: 915 ALKMSTINEAVLFEDMIALNEKPTTGKE---LSFKEPLALQESPTYKEDTFLKTLLV-PQ 970
+ST + E + EKPT E + ++ AL+ T L L++ P
Sbjct: 961 KPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTATGLAALVMSPH 1020
Query: 971 VGTSPNVSSTAPESITSKSS 990
++P S + TS+SS
Sbjct: 1021 APSTPMTSVILGTTTTSRSS 1040
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 60.5 bits (145), Expect = 1e-08
Identities = 166/809 (20%), Positives = 302/809 (37%), Gaps = 143/809 (17%)
Query: 167 EDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITK 226
E ET + L K + E+V+ L + Q ES HK + +
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES----------------HKQAQENLHD 600
Query: 227 KTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTE-----ESIPTH 281
+ K + A+Q + E S+ + + E + + + K KTE E+ T
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 282 KLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQE--KHTT 339
+ + L+ Q + + K TT+ + + +L QE
Sbjct: 661 QRADLQNHLD------------TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 340 EHEMSILKKSLAL-QKTNFKEDSLVK-ESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSR 397
H +K L+L QKT E + K E+ + + K S E+A+
Sbjct: 709 SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD---------------- 752
Query: 398 LKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSL 457
LQ+ L ++ + ++ EKE S LQKK E +
Sbjct: 753 -----LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK-------- 799
Query: 458 LKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHAT---QGTMSHLKKPLILQTTS 514
+K T +E ++ ILK+ T + + H + +QTT
Sbjct: 800 -----------------QKLTKQE----EEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
Query: 515 GEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNP 574
E +KV ++K+ E+ ++ +L D + K+ F E +
Sbjct: 839 TEL-----------QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 575 TTEETVLTKTSLSLQ-EKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEK 633
E + LQ + + T + LKK L +K S + L ++ S E+
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ-------LKLELNSMQEQL 940
Query: 634 FLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEA 693
+Q EK + ++++ + ++K E EL ++ T L Q+
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 694 LVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSA--EAATNIQTQLSLKK 751
++ AE++ + L EKS + L + + EL A + +++ +LSL +
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
Query: 752 KSTSHGKVFFLKKQLALNETINEEEFLN--KQPLALEGYPSIAEGETLFKKLLAMQEEPS 809
+ + N+ N+ + + K A S + + L ++ A+Q+
Sbjct: 1061 EDLISNR----------NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD--- 1107
Query: 810 IEKEAVLKEPTIDTE----AHFKEPLALQEEPSTEKEAVLKEPSVD-----TEAHFKETL 860
I+KE LKE + E A +E QE+ T+ LK ++ T + L
Sbjct: 1108 IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167
Query: 861 ALQEKPSIEQEALFKRHSALWEKPSTE--KETIFKESLDLQEKPSIKKETLL-----KKP 913
+Q+K ++ +A + + EK + + K+ + KE +L+ K I+KE L +K
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK-KEFIEKEAKLHSEIKEKE 1226
Query: 914 LALKMSTINEAVLFEDMIALNEKPTTGKE 942
+ +K NEA L + ALNE T K+
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKK 1255
Score = 57.0 bits (136), Expect = 1e-07
Identities = 142/636 (22%), Positives = 249/636 (39%), Gaps = 73/636 (11%)
Query: 154 FRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTF 213
+++ + E+ T E E I K L+ S + S + LQ LQ++ + +
Sbjct: 714 YKEKYLSLEQKTEELEGQIKK---LEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770
Query: 214 KKTHKTEEAAITKKTLSLKKKMCASQ---RKQSCQEESLAV---------QDVNMEEDSF 261
K + E+ ++ L L+KK A + +K + QEE + Q+ ++ +
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Query: 262 ---FMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKK 318
+++ +K K E+ +LS++K K + K + G + +
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890
Query: 319 PTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQK---------TNFKEDSLVKESLAF 369
T KE L +L V E T E LKKSL +K N ++ L++
Sbjct: 891 EKTCKE-LKHQLQVQME--NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 370 KKKPSTEEAIMMPVILKEQCMTEGKR------SRLKPLVLQEITSGEKSLIMKPLSIKEK 423
K+ E+ + + +Q + K+ LK VLQ+ T E L + ++
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK-TELENKLQQQLTQAAQE 1006
Query: 424 PSTEKESFSQEPSALQKKHTT--QEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEE 481
+ EKE S + +K T Q + S LL + + +E L+ ++ I
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 482 APP--TKKPLI--LKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKC 537
+ LI LK AT S K+ + + + + KE ++E V+ K K
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
Query: 538 TTQEMMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTS--LSLQEKKITQ 595
E + C + E + + E + K + +E K + L +Q+K Q
Sbjct: 1127 AEIEEIK-CRQ---------EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 596 GKMSHLK---------KPLVLQKITSEEESFYKKLL--PFKMKSTTEEKFLSQEPSALKE 644
GK LK + ++ ++ EEE K+ + K+ S +EK + + E
Sbjct: 1177 GKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236
Query: 645 KHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEE 704
T+Q +L+ E+L +K E + SQ S K T+ L E VL+ +
Sbjct: 1237 AKLTMQITALN-ENLGTVKK---EWQSSQRRVSELEKQTD---DLRGEIAVLEATVQNNQ 1289
Query: 705 DSLKNLLALQEKSTMEEESLINKLLALKEELSAEAA 740
D + LL K E E L K+L L+ +L A
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTA 1325
Score = 50.4 bits (119), Expect = 1e-05
Identities = 187/860 (21%), Positives = 332/860 (38%), Gaps = 124/860 (14%)
Query: 301 KPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKED 360
KP L T + S+++ E +T + ++ Q K E + + L +A K+ + E+
Sbjct: 125 KPDGLVTDSSAELQSLEQQLEEAQT--ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEE 182
Query: 361 SLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSI 420
++E+ K TEE ++++ +R ++ + + + + +M +++
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTL 242
Query: 421 KEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIE 480
+ + +EK E LQ ++ + E +I + S L K P E + + + L K E
Sbjct: 243 ERERESEK--LKDECKKLQSQYASSE-ATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 481 EAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQ 540
L +K+ T T + LKK E+ K EE VS K T
Sbjct: 300 ----------LTQKNQTL-TENLLKK---------EQDYTKLEEKHNEESVSKKNIQATL 339
Query: 541 EMMSI-CPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMS 599
+ C +L Q + + S + + + E T K LS E K
Sbjct: 340 HQKDLDCQQL---QSRLSASETS--LHRIHVELSEKGEATQKLKEELSEVETKY-----Q 389
Query: 600 HLK---KPLVLQK---------ITSEEESFYKKLLPFKMK------STTEEKFLSQEPSA 641
HLK K L Q+ + SE + KLL + + E++ LS E
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 642 LKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTD 701
KE+ ++ LS+ ++EK T E +L +K+ QE LQ+ T
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL--------DKTKQQHQEQQALQQSTT 501
Query: 702 A------------------EEDSLKNLLALQEKSTMEEESLINKLLALKEELSA-----E 738
A ++ ++NL AL +KS E SL+ K +E+L A E
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS-KENISLLEK---EREDLYAKIQAGE 557
Query: 739 AATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINE--EEFLNKQPLALEGYPSIAEGET 796
T + QL +K T +V L ++L ++ +E L+ Q + + A+
Sbjct: 558 GETAVLNQLQ-EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 797 LFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHF 856
L + ++ E S E+ K +D + K L L E + + + +DT +
Sbjct: 617 LSLE-TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN- 674
Query: 857 KETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLAL 916
ALQ+K +QE K +T+ + + + D QE S + E+ LK+
Sbjct: 675 ----ALQDK---QQEL---------NKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEK 717
Query: 917 KMSTINEAVLFEDMIALNEKPTTGKELSFKEPLA-LQESPTYKEDTFLK-TLLVPQVGTS 974
+S + E I E + + S ++ L LQ+ D L+ T L Q+
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 975 PNVSSTAPESITSKSSIATMTSVGKSGTINE---AFLFEDMITLN-EKPTTGKELSFKEP 1030
+ S+ + KS + S+ + T E L +D TL+ E +EL+ +
Sbjct: 778 KEIVSSTRLDLQKKSE--ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 1031 LALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI-TEKSSIATMTSVGKSRTTTESS 1089
+ E K + + L+ ++ T S +S+ KS GK+
Sbjct: 836 TTVTELQKVKME---KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 1090 ACESASDKPVSPQAKGTPKE 1109
C+ + + Q + T KE
Sbjct: 893 TCKELKHQ-LQVQMENTLKE 911
Score = 48.1 bits (113), Expect = 6e-05
Identities = 186/901 (20%), Positives = 340/901 (37%), Gaps = 99/901 (10%)
Query: 172 INKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSL 231
+ SL +K + E LEK Q LQ++ D V + ++ + + + ++
Sbjct: 95 LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154
Query: 232 KKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCT 291
K+ ++K + +A +E+ E+ K TEE L K+ T
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE---------LNKEAT 205
Query: 292 IYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLA 351
+ + K +LQ ++ +KK + +TL +++ +E+ + + + K
Sbjct: 206 VIQDL----KTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK---- 257
Query: 352 LQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEK 411
LQ ++ + + + K E A+ + + K +S + L + T E
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQK-------LKSSVNELTQKNQTLTEN 310
Query: 412 SLIMKP--LSIKEKPSTEKESFSQEPSALQKKHTTQEEVS--ILKEPSSLLKSPTEESPF 467
L + ++EK + E S + L +K +++ + +SL + E S
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 468 DEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFK 527
EA T+K E + K LK + K+ LQ S L + L +
Sbjct: 371 GEA---TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 528 EEKVSLKKKCTTQEMMSICPELLDFQDMIG--EDKNSFFMEPMSFRKNPTTE-ETVLTKT 584
+ + Q +S +L+D + + + K S E + + +TE + L KT
Sbjct: 428 RQLGEAHGRLKEQRQLS-SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 585 SLSLQEKKI----TQGKMSHLKKPL--VLQKITSEEESFYKKLLPFKMKSTTEEKFLSQE 638
QE++ T K+ + L VL++I +++ + L KS L +E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI-QNLEALLQKSKENISLLEKE 545
Query: 639 PSALKEK-----HTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEA 693
L K T L +++ +QE+ T + +++L + H +L +
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVT---QLTEKLKNQSESHKQAQENLHDQV 602
Query: 694 LVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLKKKS 753
+ A +D + +L E S E S +N+ +L + + LS +
Sbjct: 603 QEQKAHLRAAQDRVLSL----ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 754 TSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKE 813
T+ A N ++++ LNK L + + KL QE S + E
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQL---------DQVTAKLQDKQEHCS-QLE 708
Query: 814 AVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDT-EAHFKETLALQEKPSIEQ-- 870
+ LKE +KE E+ + E E +K+ D+ E + ALQ+ Q
Sbjct: 709 SHLKE--------YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 871 EALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDM 930
L R + L ++ EKE + LDLQ+ K E L L + +L +D
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQK----KSEALESIKQKLTKQEEEKQILKQDF 816
Query: 931 IALN-EKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESI-TSK 988
L+ E +EL+ + + E K + K L+ ++ T + S +S+ SK
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKME---KEALMTELSTVKDKLSKVSDSLKNSK 873
Query: 989 SSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEPLALQESPTCKEDTFLETF 1048
S GK+ + + T KEL K L +Q T KE L+
Sbjct: 874 SEFEKENQKGKAAIL-------------DLEKTCKEL--KHQLQVQMENTLKEQKELKKS 918
Query: 1049 L 1049
L
Sbjct: 919 L 919
Score = 31.6 bits (70), Expect = 5.6
Identities = 53/264 (20%), Positives = 99/264 (37%), Gaps = 49/264 (18%)
Query: 227 KTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKK--------------- 271
KT + +++++Q QE A+QD+ E+ E ++ K K
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Query: 272 PKTEESIPTHKLSSLK--------------KKCTIYGKICHF--------RKPPVLQTTI 309
K E + +HKL S+K +K + GK R +L+ +
Sbjct: 1141 TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV 1200
Query: 310 CGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAF 369
+KK EKE +E +HE + K ++ + N ++ KE +
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
Query: 370 KKKPSTEEA----IMMPVILKEQCMTEGKRSRLKPLVLQEITSGE---KSLIMKPLSIKE 422
+++ S E + + + E + + R +L+ GE + L K L ++
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDER--RALLERCLKGEGEIEKLQTKVLELQR 1318
Query: 423 K---PSTEKESFSQEPSALQKKHT 443
K + + +E +LQ KHT
Sbjct: 1319 KLDNTTAAVQELGRENQSLQIKHT 1342
>gi|210147567 hypothetical protein LOC220081 [Homo sapiens]
Length = 696
Score = 58.9 bits (141), Expect = 3e-08
Identities = 69/247 (27%), Positives = 110/247 (44%), Gaps = 18/247 (7%)
Query: 763 KKQLALNETINEEEFLNKQPLALE----GYPSIAEGETLFKKLLAMQEEPSIEKEAVL-K 817
K+ L E + EEE+L K+ E G E E +K ++EE IE+E L K
Sbjct: 59 KEYLEEEEDLEEEEYLGKEEYLKEEEYLGKEEHLEEEEYLEKAGYLEEEEYIEEEEYLGK 118
Query: 818 EPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRH 877
E ++ E + + L+EE KE L++ E + +E L +K +E+E +
Sbjct: 119 EGYLEEEEYLGKEEHLEEEEYLGKEGYLEK-----EDYIEEVDYLGKKAYLEEEEYLGKK 173
Query: 878 SALWEKPSTEKETIFKESLDLQEKPSIK-KETLLKKPL-ALKMSTINEAVLFEDMIALNE 935
S L E+ + EKE +E L+++ ++ KE L KK L K S ++ +L D + +
Sbjct: 174 SYLEEEKALEKEENLEEEEALEKEENLDGKENLYKKYLKEPKASYSSQTMLLRDARSPDA 233
Query: 936 KPT-----TGKELSFKEPLALQESPTYKEDTFLKTLLVPQVG-TSPNVSSTAPESITSKS 989
P+ L+F P + ES T + L Q T TA +S+ SKS
Sbjct: 234 GPSQVTTFLTVPLTFATPSPVSESATESSELLLTLYRRSQASQTDWCYDRTAVKSLKSKS 293
Query: 990 SIATMTS 996
T+
Sbjct: 294 ETEQETT 300
Score = 50.1 bits (118), Expect = 2e-05
Identities = 38/137 (27%), Positives = 70/137 (51%), Gaps = 2/137 (1%)
Query: 631 EEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEF-SQELFSLHVKHTNKSGSL 689
+E++L +E KE+H +E L K +E+ EEE+ +E + ++ K L
Sbjct: 76 KEEYLKEEEYLGKEEHLEEEEY-LEKAGYLEEEEYIEEEEYLGKEGYLEEEEYLGKEEHL 134
Query: 690 FQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSL 749
+E + +E +ED ++ + L +K+ +EEE + K L+EE + E N++ + +L
Sbjct: 135 EEEEYLGKEGYLEKEDYIEEVDYLGKKAYLEEEEYLGKKSYLEEEKALEKEENLEEEEAL 194
Query: 750 KKKSTSHGKVFFLKKQL 766
+K+ GK KK L
Sbjct: 195 EKEENLDGKENLYKKYL 211
Score = 48.1 bits (113), Expect = 6e-05
Identities = 60/243 (24%), Positives = 105/243 (43%), Gaps = 9/243 (3%)
Query: 769 NETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFK 828
+E + E L+++ L E P EGE+L K +EE E+E + KE + E +
Sbjct: 29 SEKEDTEVELDEESLQDES-PFSPEGESLEDKEYLEEEEDLEEEEYLGKEEYLKEEEYLG 87
Query: 829 EPLALQEEPSTEKEAVLKEPS-VDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTE 887
+ L+EE EK L+E ++ E + + L+E+ + +E + L ++ E
Sbjct: 88 KEEHLEEEEYLEKAGYLEEEEYIEEEEYLGKEGYLEEEEYLGKEEHLEEEEYLGKEGYLE 147
Query: 888 KETIFKESLDLQEKPSIKKETLL--KKPLALKMSTINEAVLFEDMIALNEKPTTGKELSF 945
KE +E L +K +++E L K L + + E L E+ E+ GKE +
Sbjct: 148 KEDYIEEVDYLGKKAYLEEEEYLGKKSYLEEEKALEKEENLEEEEALEKEENLDGKENLY 207
Query: 946 KEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINE 1005
K+ L ++ + L+ P G S +T + AT + V +S T +
Sbjct: 208 KKYLKEPKASYSSQTMLLRDARSPDAG-----PSQVTTFLTVPLTFATPSPVSESATESS 262
Query: 1006 AFL 1008
L
Sbjct: 263 ELL 265
Score = 43.1 bits (100), Expect = 0.002
Identities = 61/287 (21%), Positives = 122/287 (42%), Gaps = 23/287 (8%)
Query: 577 EETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLS 636
EE++ ++ S + + + + ++ L ++ +EE ++ K + EE++L
Sbjct: 40 EESLQDESPFSPEGESLEDKEYLEEEEDLEEEEYLGKEEYLKEEEYLGKEEHLEEEEYL- 98
Query: 637 QEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVL 696
++ L+E+ +E L KE +E+ +EE +E L + + +E L
Sbjct: 99 EKAGYLEEEEYIEEEEYLGKEGYLEEEEYLGKEEHLEEEEYLGKEGYLEKEDYIEEVDYL 158
Query: 697 QEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSH 756
+K EE+ L +KS +EEE + K L+EE + E N+ + +L KK
Sbjct: 159 GKKAYLEEEEY-----LGKKSYLEEEKALEKEENLEEEEALEKEENLDGKENLYKKYLKE 213
Query: 757 GKVFFLKKQLALNETINEE--------------EFLNKQPLALEGYPSIAEGETLFKKLL 802
K + + + L + + + F P++ S TL+++
Sbjct: 214 PKASYSSQTMLLRDARSPDAGPSQVTTFLTVPLTFATPSPVSESATESSELLLTLYRRSQ 273
Query: 803 AMQEEPSIEKEAV--LKEPTIDTEAHFKEPLALQEEPSTEKEAVLKE 847
A Q + ++ AV LK + +TE LA +E +T+ + +E
Sbjct: 274 ASQTDWCYDRTAVKSLKSKS-ETEQETTTKLAPEEHVNTKVQQKKEE 319
Score = 31.6 bits (70), Expect = 5.6
Identities = 57/283 (20%), Positives = 111/283 (39%), Gaps = 32/283 (11%)
Query: 140 STTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLK------KCSNHEEVSLLEKL 193
S ++P + E L+EE +E+E + K LK K + EE LEK
Sbjct: 42 SLQDESPFSPEGESLEDKEYLEEEEDLEEEEYLGKEEYLKEEEYLGKEEHLEEEEYLEKA 101
Query: 194 QPLQEESDSDDAFVI--------EPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQ 245
L+EE ++ + E K+ H EE + K+ K+ +
Sbjct: 102 GYLEEEEYIEEEEYLGKEGYLEEEEYLGKEEHLEEEEYLGKEGYLEKEDYI--EEVDYLG 159
Query: 246 EESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVL 305
+++ ++ + + S+ E + +K+ EE K +L K +Y K + ++P
Sbjct: 160 KKAYLEEEEYLGKKSYLEEEKALEKEENLEEEEALEKEENLDGKENLYKK--YLKEPKAS 217
Query: 306 QTTICGAMSSIKKPTTEKETL---------FQELSVLQEKHTTEHE--MSILKKSLALQK 354
++ + + P + F S + E T E +++ ++S A Q
Sbjct: 218 YSSQTMLLRDARSPDAGPSQVTTFLTVPLTFATPSPVSESATESSELLLTLYRRSQASQ- 276
Query: 355 TNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSR 397
T++ D +SL K K TE+ + +E T+ ++ +
Sbjct: 277 TDWCYDRTAVKSL--KSKSETEQETTTKLAPEEHVNTKVQQKK 317
Score = 31.6 bits (70), Expect = 5.6
Identities = 68/335 (20%), Positives = 123/335 (36%), Gaps = 41/335 (12%)
Query: 160 LKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESD-SDDAFVIEPMTFKKTHK 218
L +E +E+E + K L+K EEV L K L+EE +++ E +K
Sbjct: 128 LGKEEHLEEEEYLGKEGYLEKEDYIEEVDYLGKKAYLEEEEYLGKKSYLEEEKALEKEEN 187
Query: 219 TEEAAITKKTLSLK-----KKMCASQRKQSCQEESLAVQDVNMEE------DSFFMESMS 267
EE +K +L K + K S +++ ++D + +F ++
Sbjct: 188 LEEEEALEKEENLDGKENLYKKYLKEPKASYSSQTMLLRDARSPDAGPSQVTTFLTVPLT 247
Query: 268 FKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLF 327
F ES S + T+Y R+ QT C +++K ++ ET
Sbjct: 248 FATPSPVSES----ATESSELLLTLY------RRSQASQTDWCYDRTAVKSLKSKSETEQ 297
Query: 328 QELSVLQEKHTTEHEMSILKKSLALQ---KTNFKE-------DSLVKESLAFKKKPSTEE 377
+ + L + ++ K+ L+ K NF + D L E L S+ +
Sbjct: 298 ETTTKLAPEEHVNTKVQQKKEENVLEFASKENFWDGITDESIDKLEVEDLDENFLNSSYQ 357
Query: 378 AIMMPVILKEQCMTEGKRSRLKPLV-LQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPS 436
+ +I + E + PL L E + K +IM E F +
Sbjct: 358 TVFKTIIKEMAAHNELEEDFDIPLTKLLESENRWKLVIML--------KKNYEKFKETIL 409
Query: 437 ALQKKHTTQEEVSILKEPSSLLKSPTEESPFDEAL 471
++++ Q+ + L+ PT E P E +
Sbjct: 410 RIKRRREAQKLTEMTSFTFHLMSKPTPEKPETEEI 444
Score = 31.2 bits (69), Expect = 7.3
Identities = 33/142 (23%), Positives = 68/142 (47%), Gaps = 8/142 (5%)
Query: 317 KKPTTEKETLFQELSVLQEKHTTEHEM----SILKKSLALQKTNF-KEDSLVKESLAFKK 371
K+ E+E L +E + +E++ E E L++ L+K + +E+ ++E K
Sbjct: 59 KEYLEEEEDLEEEEYLGKEEYLKEEEYLGKEEHLEEEEYLEKAGYLEEEEYIEEEEYLGK 118
Query: 372 KPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESF 431
+ EE + KE+ + E + + + +E E + K ++E+ K+S+
Sbjct: 119 EGYLEEEEYLG---KEEHLEEEEYLGKEGYLEKEDYIEEVDYLGKKAYLEEEEYLGKKSY 175
Query: 432 SQEPSALQKKHTTQEEVSILKE 453
+E AL+K+ +EE ++ KE
Sbjct: 176 LEEEKALEKEENLEEEEALEKE 197
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 58.5 bits (140), Expect = 4e-08
Identities = 179/884 (20%), Positives = 331/884 (37%), Gaps = 110/884 (12%)
Query: 144 KTPNTEEASLFRKPLVLKEEPTIEDETL-INKSLSLKKCSNHEEVSL-LEKLQPLQEESD 201
KT ++ + F+ + KE +++E L + +++ KC++ + L LE + E+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 202 SDDAFVIEPMTFKKTHKTEEA--AITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEED 259
+ +FKKT + E + + + L+K + S +K E L QD+ ME
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL--QDLEMENQ 794
Query: 260 SFFMESMSFKKKPKTEESIP---------THKLSSLKKKCTIYGKICHFRKPPVLQTTIC 310
+ K K E + T +L KK+ K ++ + TT+
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR-QQAEIKDTTLE 853
Query: 311 GAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKT-------NFKEDSLV 363
I E +TL +E+ + +E E+ K L + T +ED LV
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-LV 912
Query: 364 KESLAFKKKPSTEEAIMMPV---------ILKEQCMTEGKRSRLKPLVLQEITSGEKSLI 414
E L ++ + E + + +L ++ T+ R +L L+ +KSL
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL--KKSLE 970
Query: 415 MKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSS---LLKSPTEESPFDEAL 471
+K I + +ES + Q+ T ++ LK+ +++S S D
Sbjct: 971 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
Query: 472 AFTKKCTIEEAPPTKKPLI-LKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEK 530
+ T E K LI ++R +AT K + Q + +L + L + +
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 531 VSLKKKCTTQEM----MSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSL 586
VSL+++ TT + + + L+ Q ++N+ + S +N +
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
Query: 587 SLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKH 646
SL + I H K L+ ++ SE ES K K + K L E L++++
Sbjct: 1151 SLYDSLIKD----HEKLELLHERQASEYESLISKHGTLK----SAHKNLEVEHRDLEDRY 1202
Query: 647 TTL-----QEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTD 701
L Q L K QEK E + + + + + K ++ L L ++T+
Sbjct: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
Query: 702 AEEDSLKNLLALQEKSTMEEESLINKLLALKEELS----AEAATNIQTQLSLKKKSTSHG 757
+ KNL +L S +E+ L + LKE+ N Q +L + K
Sbjct: 1263 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1322
Query: 758 KVFFLKKQLAL----NETINEEEFLNKQPLALEGYPSIAEGETLFKKLLAMQE------- 806
+ L Q+ N T+ E+ +K +E I + L ++ ++E
Sbjct: 1323 ENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382
Query: 807 --EPS----------IEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEA 854
+PS ++ ++K D ++ L L S E L+ P D+
Sbjct: 1383 FYDPSPPRRRGNWITLKMRKLIKSKK-DINRERQKSLTLTPTRSDSSEGFLQLPHQDS-- 1439
Query: 855 HFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETI-----------FKESLDLQEKPS 903
Q+ S+ +L + +K ST + + E+L++ + S
Sbjct: 1440 --------QDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDIS 1491
Query: 904 IKKE-----TLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKE 942
K + A+ ST+N + F +N K TT E
Sbjct: 1492 TGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFE 1535
Score = 40.8 bits (94), Expect = 0.009
Identities = 161/768 (20%), Positives = 296/768 (38%), Gaps = 133/768 (17%)
Query: 160 LKEEPTIEDETLINKSLSLKKCSN------HEEVSLLEKLQPLQEESDSDDAFVIEPMTF 213
L ++ I + ++ + SL+ C N E+ L + ++ L+E S+ I+ +
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ----IKILEQ 558
Query: 214 KKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPK 273
+ H + T +L + ++ A R + ++E+ + + +++E S + + F+K+
Sbjct: 559 ENEHLNQ----TVSSLRQRSQISAEARVKDIEKENKILHE-SIKETSSKLSKIEFEKRQI 613
Query: 274 TEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVL 333
+E H ++ + ++ H K L KK T K T + ++
Sbjct: 614 KKEL--EHYKEKGERAEELENELHHLEKENELLQ---------KKITNLKITCEKIEALE 662
Query: 334 QEKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEG 393
QE E E LKK+L +FK + ESL + EE + + ++
Sbjct: 663 QENSELERENRKLKKTL----DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASM 718
Query: 394 KRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSI--L 451
K ++L+ L +E+ S EK + K L + K SF K T + EVS L
Sbjct: 719 KMAQLQ-LENKELES-EKEQLKKGLELL------KASF---------KKTERLEVSYQGL 761
Query: 452 KEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLK--KPLI 509
+ L+ E S KK I++ + L ++ + Q + LK +
Sbjct: 762 DIENQRLQKTLENS--------NKK--IQQLESELQDLEMENQ-TLQKNLEELKISSKRL 810
Query: 510 LQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFMEPMS 569
Q KSL +E +++K L+K E+K + +
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEK----------------------ENKR---LRQQA 845
Query: 570 FRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYK------KLLP 623
K+ T EE + +L + K +++ + + + L+++ E + K K L
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 624 FKMKSTTEEKFLSQEPSALKEKHT-TLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKH 682
+ EK +Q+ + EK T L+++ L+KE L E++T + + +L ++
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY--KLLESKLES 963
Query: 683 TNKSGSLFQEALVLQEKTDAEEDSLKNLLALQE-----------KSTMEEESLINKLLAL 731
T K +E + + EE + N QE K +EE ++ +
Sbjct: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1023
Query: 732 K-EELSAEAATNIQTQLSLKKK----------STSHGKVFFLKKQLALNETINEEEFLNK 780
E+ E + T+ LK K +T + LK QL ET N L
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN--LQA 1081
Query: 781 QPLALEGYP-SIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPST 839
Q LAL+ S+ E T L Q + + L + + L Q
Sbjct: 1082 QILALQRQTVSLQEQNT----TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
Query: 840 EKEAVLKEPSVDTEAHFKETL-------ALQEKPSIEQEALFKRHSAL 880
E E+V+KE D ++ + + L E+ + E E+L +H L
Sbjct: 1138 ENESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 58.2 bits (139), Expect = 6e-08
Identities = 164/845 (19%), Positives = 313/845 (37%), Gaps = 155/845 (18%)
Query: 197 QEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNM 256
+E+ S +A ++E ++ K E + K L+ K + E AV+D+N
Sbjct: 349 EEDKLSQNACILESVSEKTERSNSEDKLNSKILN---------EKPTTDEPEKAVEDINE 399
Query: 257 EEDSFFMESMSF-------------KKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPP 303
+E+M+ +K+PK E T ++ GK +
Sbjct: 400 HITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMI-- 457
Query: 304 VLQTTICGAMSSIKKPTTEKETLFQELSVLQE--KHTTEHEMSILKKSLALQKTNFK--- 358
L+T I + S ++ EK+ +F+ + E K T + ++ + ++ N +
Sbjct: 458 TLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVD 517
Query: 359 -EDSLVKESLAFKKKPSTEEAIMMPVILKE-------------QCMTEGKRSRLKPLVLQ 404
E L KE ++K ++ VI Q + E + +
Sbjct: 518 SEVGLTKEDT--QEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGK 575
Query: 405 EITSGEKSLIMKPL------SIKEKPSTEKESFSQEPSALQKKHTTQEEVSIL---KEPS 455
E+ + LI KP+ KE P E ++ K+ +I+ +EP
Sbjct: 576 EVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPG 635
Query: 456 SLL------KSPTEESPFDEALAFT-KKCTIEEAPPTKKPLILKRKHATQGTMSHLKKP- 507
+ S TEE +A T +K E K K + +S K+P
Sbjct: 636 TTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPE 695
Query: 508 --LILQTTSGEKSLI------KEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGED 559
++ Q T + LI + KEE SL K T S P+ D G
Sbjct: 696 VTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGST 755
Query: 560 KN----------SFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQK 609
+ S F+ + + +ET K +L K I G ++ + K
Sbjct: 756 ADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDG----VEVSVTTSK 811
Query: 610 ITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTT------------LQEVSLSKE 657
I ++ +S ++L + + E +FL +E +++ + ++ +SK+
Sbjct: 812 IVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKK 871
Query: 658 SLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKS 717
QE E++ Q + L +HTN+ L EA ++ + + E +N+L ++K
Sbjct: 872 RQYDQEIENLEKQQKQTIERLEQEHTNR---LRDEAKRIKGEQEKELSKFQNMLKNRKKE 928
Query: 718 TMEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEF 777
+ E K L++EL +K++ K++LA ++ E+EF
Sbjct: 929 VINEVEKAPK--ELRKEL-------------MKRR----------KEELAQSQHAQEQEF 963
Query: 778 LNKQPLALEGYPSIAEGETLFKKLLAMQ--EEPSIEKEAVLKEPTIDTEAHFKEPLALQE 835
+ KQ L+G KK++ Q E +IE+E + + + A L+E
Sbjct: 964 VQKQQQELDG---------SLKKIIQQQKAELANIERECLNNKQQL-MRAREAAIWELEE 1013
Query: 836 EPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKES 895
EK +LK+ L+++ +++ L KRH E+ + + +E
Sbjct: 1014 RHLQEKHQLLKQ-------------QLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEEL 1060
Query: 896 LDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESP 955
+ Q + + + + +M+ +F+ + +N T ++ + A QE
Sbjct: 1061 KNRQTQERARLPKIQRSEAKTRMA------MFKKSLRINSTATPDQDRDKIKQFAAQEEK 1114
Query: 956 TYKED 960
K +
Sbjct: 1115 RQKNE 1119
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 57.4 bits (137), Expect = 9e-08
Identities = 210/994 (21%), Positives = 370/994 (37%), Gaps = 84/994 (8%)
Query: 33 TGENCQTKISPSSLQESPSSLQGA--LKKRSAFEDLTNASQ-CQPVQPKKEANKEFVKVV 89
+G + T+ S SS+ SPS +GA + + L+N + C + KE ++ +
Sbjct: 45 SGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQAL 104
Query: 90 SKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPL------ILDISTTS 143
+ + + + + R+L+ + A + + + E+ + +L +
Sbjct: 105 NDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAAR 164
Query: 144 KTPNTEEASLF------RKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQ 197
E+ L R+ L + E E + + V L +K Q LQ
Sbjct: 165 GQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQ 224
Query: 198 EESD----SDDAFVIEPMTFKKTHKTEEAAITKKTL-SLKKKMCASQRKQSCQEESLAVQ 252
EE V E + + +A + +T +LK + ++ R+ Q E AVQ
Sbjct: 225 EECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQ 284
Query: 253 DVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGA 312
E+ F + + K + T + S +++ T Y R+ +TT A
Sbjct: 285 STLQSEEWFRVRLDRLSEAAK----VNTDAMRSAQEEITEY------RRQLQARTTELEA 334
Query: 313 MSSIKKPTTEKETLFQELSVLQEKHTTE---HEMSILKKSLALQKTNFKEDSLVKES--- 366
+ S K ++L ++ S L+++H + ++ +I + L+ T ++ + ++E
Sbjct: 335 LKSTK------DSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDL 388
Query: 367 LAFKKKPSTEEAIMMPVILKEQCMTE-GKRSRLKPLVLQEITSGEKSLIMKPLS-IKEKP 424
L K E A ++ E+C G P L +I S + +K IK
Sbjct: 389 LNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVE 448
Query: 425 STEKESFSQEPSALQKKHT---TQEEVSILKEPSSLLKSPTEESPFDEALAFTKKCTIEE 481
+EKE+ E + + T T+EE KE + EE + TK EE
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 482 APPTKKPLILKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQE 541
A +K A K P + S EK K P K + K K +E
Sbjct: 509 AASPEK-------EAKSPVKEEAKSPA--EAKSPEKEEAKSPAEVKSPE---KAKSPAKE 556
Query: 542 MMSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQEKKITQGKMS-- 599
PE + E K+ ++ K+P EE + S ++ K + +
Sbjct: 557 EAKSPPEAKSPEKE--EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 600 --HLKKPLVLQ-KITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTLQEVSLSK 656
K P+ + K +E +S K P K ++ + EK S E K V
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 657 ESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEEDS-LKNLLALQE 715
+S + E S E VK KS + + + K+ + S +K E
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 716 K--STMEEESLINKLLALKEELSAEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETIN 773
K S ++EE+ + E+ + + + K+++ S F K + + E +
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 774 EEEFLNKQPL---ALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEP 830
E K PL A I + E + K + +E+P +E +KEP E K P
Sbjct: 795 SPEKA-KSPLKEDAKAPEKEIPKKEEV-KSPVKEEEKP---QEVKVKEPPKKAEEE-KAP 848
Query: 831 LA--LQEEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEK 888
+E+ ++KE K+ + + K+ A+++ + EA + + P+ EK
Sbjct: 849 ATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK 908
Query: 889 ETIFKESLDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEP 948
E K + KP K E K+P K ++ E A EK T +E + K
Sbjct: 909 EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA--EKKEAAPEKKDTKEEKAKKPE 966
Query: 949 LALQESPTYKED--TFLKTLLVPQVGTSPNVSST 980
+ KED T K P+ + SST
Sbjct: 967 EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 43.9 bits (102), Expect = 0.001
Identities = 107/527 (20%), Positives = 192/527 (36%), Gaps = 47/527 (8%)
Query: 6 PPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKRSAFED 65
PP P+K S + P+E + SP+ ++ + A ++ + +
Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 66 LTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTT 125
+ + + P + + E K +K+ ++ +K K + K E + +
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV---KEEAKSPAEAKS 620
Query: 126 VVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLIN------KSLSLK 179
V + P + +K+P EEA K ++E E + KS
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Query: 180 KCSNHEEVSLLEKLQ-PLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCAS 238
K E EK + P++EE+ S + K+ EEA +K S K+ +
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEK--------AKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 239 --QRKQSCQEESLAVQDVNMEE--DSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYG 294
+ K +EE+ + + E + ++S K K E P K K K +
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE-KAKSPVKE 791
Query: 295 KICHFRKPPVLQTTI----------CGAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMS 344
++ + P ++ + +K P E+E QE+ V + E E +
Sbjct: 792 EV---KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-QEVKVKEPPKKAEEEKA 847
Query: 345 ILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTEGKRSRLKPLVLQ 404
+K + KE++ KE+ K + E A+ P K + E + K +
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK-KKVPTP 906
Query: 405 EITSGEKSLIMKPLSIKEKPSTEK----ESFSQEPSALQKKHTTQEEVSILKEPSSLLKS 460
E + K + + KEK K ++ ++EPS +K E KE + K
Sbjct: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA--KK 964
Query: 461 PTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKP 507
P EE P EA A T+ + P KP K + ++ K P
Sbjct: 965 P-EEKPKTEAKAKEDDKTLSKEP--SKPKAEKAEKSSSTDQKDSKPP 1008
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.0 bits (136), Expect = 1e-07
Identities = 134/630 (21%), Positives = 251/630 (39%), Gaps = 51/630 (8%)
Query: 144 KTPNTEEASLFRKPLVLKEEPTIEDETL-INKSLSLKKCSNHEEVSL-LEKLQPLQEESD 201
KT ++ + F+ + KE +++E L + +++ KC++ + L LE + E+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 202 SDDAFVIEPMTFKKTHKTEEA--AITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEED 259
+ +FKKT + E + + + L+K + S +K E L QD+ ME
Sbjct: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL--QDLEMENQ 794
Query: 260 SFFMESMSFKKKPKTEESIP---------THKLSSLKKKCTIYGKICHFRKPPVLQTTIC 310
+ K K E + T +L KK+ K ++ + TT+
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR-QQAEIKDTTLE 853
Query: 311 GAMSSIKKPTTEKETLFQELSVLQEKHTTEHEMSILKKSLALQKT-------NFKEDSLV 363
I E +TL +E+ + +E E+ K L + T +ED LV
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-LV 912
Query: 364 KESLAFKKKPSTEEAI---MMPVILKEQCMTEGKRS---RLKPLVLQEITSGEKSLIMKP 417
E L ++ + E + + + L ++ + ++S R K L + ++ +KSL +K
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKE 972
Query: 418 LSIKEKPSTEKESFSQEPSALQKKHTTQEEVSILKEPSS---LLKSPTEESPFDEALAFT 474
I + +ES + Q+ T ++ LK+ +++S S D
Sbjct: 973 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032
Query: 475 KKCTIEEAPPTKKPLI-LKRKHATQGTMSHLKKPLILQTTSGEKSLIKEPLPFKEEKVSL 533
+ T E K LI ++R +AT K + Q + +L + L + + VSL
Sbjct: 1033 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1092
Query: 534 KKKCTTQEM----MSICPELLDFQDMIGEDKNSFFMEPMSFRKNPTTEETVLTKTSLSLQ 589
+++ TT + + + L+ Q ++N+ + S +N + SL
Sbjct: 1093 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1152
Query: 590 EKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPFKMKSTTEEKFLSQEPSALKEKHTTL 649
+ I H K L+ ++ SE ES K K + K L E L++++ L
Sbjct: 1153 DSLIKD----HEKLELLHERQASEYESLISKHGTLK----SAHKNLEVEHRDLEDRYNQL 1204
Query: 650 -----QEVSLSKESLAIQEKATTEEEFSQELFSLHVKHTNKSGSLFQEALVLQEKTDAEE 704
Q L K QEK E + + + + + K ++ L L ++T+ +
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1264
Query: 705 DSLKNLLALQEKSTMEEESLINKLLALKEE 734
KNL +L S +E+ L + LKE+
Sbjct: 1265 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,260,967
Number of Sequences: 37866
Number of extensions: 2431393
Number of successful extensions: 10764
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 535
Number of HSP's that attempted gapping in prelim test: 8464
Number of HSP's gapped (non-prelim): 2014
length of query: 1395
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1280
effective length of database: 13,892,928
effective search space: 17782947840
effective search space used: 17782947840
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.