BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|88702793 slit-like 2 [Homo sapiens] (673 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|88702793 slit-like 2 [Homo sapiens] 1360 0.0 gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 140 3e-33 gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 136 7e-32 gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 133 5e-31 gi|51317373 netrin-G1 ligand [Homo sapiens] 132 1e-30 gi|194440719 chondroadherin-like [Homo sapiens] 130 5e-30 gi|27363458 leucine rich repeat and fibronectin type III domain ... 129 1e-29 gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 127 3e-29 gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 127 3e-29 gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 127 4e-29 gi|4758460 glycoprotein V (platelet) [Homo sapiens] 125 1e-28 gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 124 4e-28 gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 120 4e-27 gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 120 4e-27 gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 120 4e-27 gi|198041768 synleurin [Homo sapiens] 119 9e-27 gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 117 3e-26 gi|153251229 chondroadherin precursor [Homo sapiens] 115 1e-25 gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 112 1e-24 gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 111 2e-24 gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 108 1e-23 gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 108 1e-23 gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 108 1e-23 gi|13375646 leucine rich repeat and fibronectin type III domain ... 108 2e-23 gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 108 2e-23 gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 107 3e-23 gi|225579152 insulin-like growth factor binding protein, acid la... 107 5e-23 gi|4826772 insulin-like growth factor binding protein, acid labi... 107 5e-23 gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 106 6e-23 gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 106 6e-23 >gi|88702793 slit-like 2 [Homo sapiens] Length = 673 Score = 1360 bits (3521), Expect = 0.0 Identities = 673/673 (100%), Positives = 673/673 (100%) Query: 1 MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF 60 MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF Sbjct: 1 MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF 60 Query: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF Sbjct: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120 Query: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNS 180 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNS Sbjct: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNS 180 Query: 181 LLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG 240 LLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG Sbjct: 181 LLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG 240 Query: 241 LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF 300 LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF Sbjct: 241 LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF 300 Query: 301 NCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPT 360 NCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPT Sbjct: 301 NCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPT 360 Query: 361 TRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTC 420 TRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTC Sbjct: 361 TRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTC 420 Query: 421 HLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGL 480 HLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGL Sbjct: 421 HLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGL 480 Query: 481 QRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGP 540 QRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGP Sbjct: 481 QRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGP 540 Query: 541 GRVPEGEEACGEAHTPPAVHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVR 600 GRVPEGEEACGEAHTPPAVHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVR Sbjct: 541 GRVPEGEEACGEAHTPPAVHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVR 600 Query: 601 RGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPG 660 RGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPG Sbjct: 601 RGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPG 660 Query: 661 PGLQSPLHAKPYI 673 PGLQSPLHAKPYI Sbjct: 661 PGLQSPLHAKPYI 673 >gi|15029530 leucine rich repeat containing 4 [Homo sapiens] Length = 653 Score = 140 bits (354), Expect = 3e-33 Identities = 110/348 (31%), Positives = 163/348 (46%), Gaps = 29/348 (8%) Query: 8 LLPLLLLLALGPGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITM 66 +L + A G Q CPS C CS Q V CT R + VP+ +P +T L + EN I M Sbjct: 30 ILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQM 89 Query: 67 LDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRL 126 + A +F L L++L L +N I + G F LA+L+ L+L N L I + F L +L Sbjct: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149 Query: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLAL-- 184 L+L N I I AF+ R+P L+ LDL L Sbjct: 150 RELWLRNNPIESIPSYAFN---------------------RVPSLMRLDLGELKKLEYIS 188 Query: 185 EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTR 243 E N++ L L ++ + + L L +L++S N + P GL L + Sbjct: 189 EGAFEGLFNLKYLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKK 246 Query: 244 LRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCV 303 L + N++++ + GLA+L EL++++ +L +LP DL L L NP+NC Sbjct: 247 LWVM-NSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCD 305 Query: 304 CPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPA 351 C + W W+RE ++ S RCH P GR L+E+D A F C A Sbjct: 306 CDILWLAWWLRE-YIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSA 352 >gi|122937309 leucine rich repeat containing 4B [Homo sapiens] Length = 713 Score = 136 bits (342), Expect = 7e-32 Identities = 116/372 (31%), Positives = 174/372 (46%), Gaps = 52/372 (13%) Query: 19 PGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPG 77 P CP C CS Q V CT R VP +P +T L + ENGI ++ +F L Sbjct: 52 PPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111 Query: 78 LQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR 137 L++L LS+N + + G F L +L+ L+L NRL + + F L +L L+L N I Sbjct: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171 Query: 138 HIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGILDTANVEAL 197 I AF+ + L L L + L L + S A E G+++ L Sbjct: 172 SIPSYAFNRVPSLRRLDLGE---------------LKRLEYISEAAFE-GLVN------L 209 Query: 198 RLAGLGLQQL-DEGLFSRLRNLHDLDVSDNQLERVPP-VIRGLRGLTRLRLAGNTRIAQL 255 R LG+ L D + L L +L++S N+L+ + P +GL L +L L + ++A + Sbjct: 210 RYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLM-HAQVATI 268 Query: 256 RPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRE 315 L +L+EL++S+ +L +LP DL RL + NP++C C + W W++E Sbjct: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKE 328 Query: 316 ---SHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALS 372 S+ T + RCH P GR + ELD + F C A PV+ EP Sbjct: 329 TVPSNTTCCA----RCHAPAGLKGRYIGELDQSHFTCYA-----------PVIVEP---- 369 Query: 373 SSLAPTWLSPTE 384 PT L+ TE Sbjct: 370 ----PTDLNVTE 377 >gi|76880480 hypothetical protein LOC9865 [Homo sapiens] Length = 811 Score = 133 bits (335), Expect = 5e-31 Identities = 135/456 (29%), Positives = 180/456 (39%), Gaps = 79/456 (17%) Query: 7 LLLPLLLLLALGPGVQG-CPSGCQCSQPQTVFCTARQGTTVPRDV----PPDTVGLYVFE 61 LLL + LAL P + CP C C PQ + CT R VP+ P D + + Sbjct: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68 Query: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121 N IT + A F L L+ LDL NQI SL F+ L+ L L L N L + T Sbjct: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128 Query: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP-----PL---------- 166 LR+L LY N I + G+F+ L+ L++L+L N L ALP PL Sbjct: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES 188 Query: 167 ------------RLPRLLLLDLSHNSLLALEPGILDTANVEALR------LAGLGLQQLD 208 +L +L L+LS N L+P + A LR L+ LQ L Sbjct: 189 NRIRFLGKNAFAQLGKLRFLNLSANE---LQPSLRHAATFAPLRSLSSLILSANNLQHLG 245 Query: 209 EGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTRLRLAGN------------------ 249 +F L L L + NQL + P GL L LRL GN Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305 Query: 250 -----TRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVC 304 ++ L P L L+EL + N +L AL GD+ P L L N + C C Sbjct: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365 Query: 305 PL----SWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELD---YADFGCPATTTTAT 357 L W G W + + +C PP G+ L LD + C + +A+ Sbjct: 366 RLRGLKRWMGDWHSQGRLLTVF---VQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSAS 422 Query: 358 VPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPP 393 + R PTA + P P A E P P Sbjct: 423 LTADRRRQPLPTAAGEEMTP----PAGLAEELPPQP 454 >gi|51317373 netrin-G1 ligand [Homo sapiens] Length = 640 Score = 132 bits (332), Expect = 1e-30 Identities = 116/373 (31%), Positives = 169/373 (45%), Gaps = 49/373 (13%) Query: 7 LLLPLLLLLALG-PGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGI 64 +LL L LL+ G Q CPS C CS Q V C + VP + +T L + EN I Sbjct: 29 VLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88 Query: 65 TMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLR 124 ++ SF L L++L LS+N I ++ G F LANL+ L+L NRL I N F L Sbjct: 89 QIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLS 148 Query: 125 RLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLAL 184 +L+ L+L N I I AF+ R+P L LDL L+ Sbjct: 149 KLKELWLRNNPIESIPSYAFN---------------------RIPSLRRLDLGELKRLSY 187 Query: 185 --EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIRGLRGL 241 E +N+ L LA L+++ + L L +LD+S N L + P +GL L Sbjct: 188 ISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHL 245 Query: 242 TRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFN 301 +L + ++I + L +L E+++++ +L LP DL L + NP+N Sbjct: 246 QKLWMI-QSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWN 304 Query: 302 CVCPLSWFGPWVRESHVTLASPEET----RCHFPPKNAGRLLLELDYADFGCPATTTTAT 357 C C + W W+++ +P T RC+ PP GR + ELD F C A Sbjct: 305 CNCDILWLSWWIKD-----MAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYA------ 353 Query: 358 VPTTRPVVREPTA 370 PV+ EP A Sbjct: 354 -----PVIVEPPA 361 >gi|194440719 chondroadherin-like [Homo sapiens] Length = 762 Score = 130 bits (326), Expect = 5e-30 Identities = 132/423 (31%), Positives = 173/423 (40%), Gaps = 36/423 (8%) Query: 3 SRVPLLLPLLLLLALGPG----VQGCPSGCQCSQPQT-VFCTARQGTTVPRDVPPDTVGL 57 + VPL+LPLL+LL L P Q CP C C + V C + T VP +P T L Sbjct: 8 THVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRL 67 Query: 58 YVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITN 117 + N + ++ A +F G+P L LDL ++ + G F+ L L L+L +N L E+ Sbjct: 68 DLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQ 127 Query: 118 ETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLR---LPRLLLL 174 E GL L RL L N + ++PG F L L L L N L LP + L R+ L Sbjct: 128 EALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWL 187 Query: 175 DLSHNSLLALEPGILDTANVEALRLAGL---GLQQLDEGLFSRLRNLHDLDVSDNQLERV 231 LSHN+L L P L A + ALR L LQ L + S+ R L L++ N L Sbjct: 188 RLSHNALSVLAPEAL--AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYA 245 Query: 232 PPVI-RGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRL 290 L GL L L G + L P A L LD+ L LP L G +L Sbjct: 246 GEEDGLALPGLRELLLDGGA-LQALGPRAFAHCPRLHTLDLRGNQLDTLP-PLQGP-GQL 302 Query: 291 RLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCP 350 R L NP C C W+ + V + C P + G L L D CP Sbjct: 303 RRLRLQGNPLWCGCQARPLLEWLARARVR----SDGACQGPRRLRGEALDALRPWDLRCP 358 Query: 351 ATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCP 410 E A++ AP P P E V P P+ C Sbjct: 359 GDAAQEEEEL------EERAVAGPRAPPRGPPRGPGEER---------AVAPCPRACVCV 403 Query: 411 PST 413 P + Sbjct: 404 PES 406 Score = 101 bits (252), Expect = 2e-21 Identities = 108/366 (29%), Positives = 151/366 (41%), Gaps = 27/366 (7%) Query: 18 GPG----VQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSF 72 GPG V CP C C + + C VPR P DT L + N + +F Sbjct: 386 GPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAF 445 Query: 73 AGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLG 132 GL L L L IA L +G L L L L+ N+L ++ G RL LYL Sbjct: 446 PGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLE 505 Query: 133 KNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPR---LLLLDLSHNSLLALEPGIL 189 +NR + A L L L LQDN + L P L R L + LS N + + G L Sbjct: 506 RNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGAL 565 Query: 190 DTA-NVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-----PPVIRGLRGLTR 243 A +E L L L+++ G L L +L +S N L + PV R L+ L Sbjct: 566 GPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHL-- 623 Query: 244 LRLAGNTRIAQLRPEDLAGLA-ALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNC 302 ++ + Q+ P +GL LQ L + L+ALP S +L L+ + NPF+C Sbjct: 624 --FLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPS--LSQLELIDLSSNPFHC 679 Query: 303 VCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCP--ATTTTATVPT 360 C L W+ ++ + + C PP G+ + CP A P Sbjct: 680 DCQLLPLHRWLTGLNLRVGA----TCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPA 735 Query: 361 TRPVVR 366 +RP R Sbjct: 736 SRPSAR 741 >gi|27363458 leucine rich repeat and fibronectin type III domain containing 4 [Homo sapiens] Length = 635 Score = 129 bits (323), Expect = 1e-29 Identities = 176/673 (26%), Positives = 246/673 (36%), Gaps = 148/673 (21%) Query: 8 LLPLLLLLALGPGVQGCPSGCQC---SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGI 64 + P LLLL L G CP C C S+ + C R VP +V TV L + +N I Sbjct: 1 MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFI 60 Query: 65 TMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLR 124 L F + GL L LS+N I + + F L +L +L L NRL E+ + RG Sbjct: 61 QALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPV 120 Query: 125 RLERLYLGKNRIRHIQPGAFDT-LDRLLELKLQDNELRALPPL---RLPRLLLLDLSHNS 180 L+ L L N++ I PGAFD L+ L +L L N LR +P +P L L+L HN Sbjct: 121 NLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNL 180 Query: 181 LLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG 240 + AL P G F++L L LD++ N+L + P RG Sbjct: 181 IDALPP-----------------------GAFAQLGQLSRLDLTSNRLATLAPDPLFSRG 217 Query: 241 LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF 300 R A+ P L +L+ + NP Sbjct: 218 ----------RDAEASPAPL-------------------------------VLSFSGNPL 236 Query: 301 NCVCPLSWFGPWVRESHVTLASPEETR-CHFPPKNAGRLLLELDYADFGCPATTTTATVP 359 +C C L W LA P++ C PP AGR + +F C Sbjct: 237 HCNCELLWLR--------RLARPDDLETCASPPGLAGRYFWAVPEGEFSC---------- 278 Query: 360 TTRPVVREPTALSSSLAPTWLSPTEPAT---EAPSPPSTAPPTVGPVPQ------PQDCP 410 EP ++ W+ + AT A P+ VGP + Sbjct: 279 -------EPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAF 331 Query: 411 PSTCLNGGTCHLGTRHHLACLC--PEGFTGLYCE----------SQMGQGTRPSPTPVTP 458 P+ L G G C+ P G E + +G RP P+ + Sbjct: 332 PNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALPHGGNSSAEGGRPGPSDIAA 391 Query: 459 RPPRSL----TLGIEP---VSPTSLRVGLQRYLQGSSVQ-LRSLRLTYRNLSGPDKRLVT 510 + TL EP V+ + GL + G + ++ Y S D+ L+ Sbjct: 392 SARTAAEGEGTLESEPAVQVTEVTATSGLVSWGPGRPADPVWMFQIQYN--SSEDETLIY 449 Query: 511 LRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEEA-----CGEAHTPPAVHSNHAP 565 +PAS + + L P A Y +C++ L P P A C T PA HA Sbjct: 450 RIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPASPLCHAL 509 Query: 566 VTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVRRGRAMAAAAQDKGQVGPGAGPLELE 625 G L + A+ VL+AAL A V RGR G G PL+L Sbjct: 510 QAHVLGGTLTV----AVGGVLVAALLVFTVALLV-RGRG----------AGNGRLPLKLS 554 Query: 626 GVKVPLEPGPKAT 638 V+ GP T Sbjct: 555 HVQSQTNGGPSPT 567 >gi|205277468 leucine rich repeat containing 15 isoform a [Homo sapiens] Length = 587 Score = 127 bits (320), Expect = 3e-29 Identities = 99/299 (33%), Positives = 141/299 (47%), Gaps = 11/299 (3%) Query: 5 VPLLLPLLLLL---ALGPGV--QGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYV 59 +PL LLLL+ A G G+ GCPS C CS+ V CT + VP +P + + L + Sbjct: 7 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 66 Query: 60 FENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNET 119 IT L+ F + L L + +N+++ + G F+ L +L L L N+L + Sbjct: 67 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 126 Query: 120 FRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDL 176 F+GL LE L L N++ IQP F L EL+L N L +P L L L+L Sbjct: 127 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 186 Query: 177 SHNSLLALEPGILD-TANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-V 234 NSL + P + N++ LRL L + G F L NL +L + NQ+ + P + Sbjct: 187 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 246 Query: 235 IRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLL 293 L RL L+ N I+QL P L L L + SL+ L + G P LR L Sbjct: 247 FHNNHNLQRLYLS-NNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 304 Score = 100 bits (248), Expect = 6e-21 Identities = 101/365 (27%), Positives = 155/365 (42%), Gaps = 44/365 (12%) Query: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116 L ++EN +T + G+F GL LQ L L QNQI L G+F NL L L+ N + ++ Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267 Query: 117 NETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLL 173 F L +L RL L N ++ + G F + L EL L DN + +LP L +L + Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327 Query: 174 LDLSHNSLLALEPGILD-TANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP 232 L LS N + + PG + + L L LQ LD +F L NL ++ + +N+L ++P Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387 Query: 233 PVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 GN A + L + + N L+ LP G+F L Sbjct: 388 ---------------GNI---------FANVNGLMAIQLQNNQLENLP---LGIFDHLGK 420 Query: 293 LAAAR---NPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF-- 347 L R NP+ C + W+ + L + C P G+ L+ ++ Sbjct: 421 LCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVP 480 Query: 348 -----GCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGP 402 P+ T P T P + T++SS+ T SP E T+ + T +V Sbjct: 481 SVHVPEVPSYPETPWYPDT-PSYPDTTSVSSTTELT--SPVEDYTDLTTIQVTDDRSVWG 537 Query: 403 VPQPQ 407 + Q Q Sbjct: 538 MTQAQ 542 Score = 72.0 bits (175), Expect = 2e-12 Identities = 39/113 (34%), Positives = 63/113 (55%) Query: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR 111 P+ L++++N I+ L F+ L LQ+L LS+NQI+ + G F L L L L N Sbjct: 299 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA 358 Query: 112 LHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP 164 L ++ FR L L+ + L NR+R + F ++ L+ ++LQ+N+L LP Sbjct: 359 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411 Score = 70.9 bits (172), Expect = 4e-12 Identities = 49/142 (34%), Positives = 67/142 (47%), Gaps = 3/142 (2%) Query: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR 111 P L +F N + L G F +P L+ L L N I+SLP VF L L L L+ N+ Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334 Query: 112 LHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRL 168 + I+ F GL L L L N ++ + F L L + LQ+N LR LP + Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394 Query: 169 PRLLLLDLSHNSLLALEPGILD 190 L+ + L +N L L GI D Sbjct: 395 NGLMAIQLQNNQLENLPLGIFD 416 >gi|18677767 leucine rich repeat containing 15 isoform b [Homo sapiens] Length = 581 Score = 127 bits (320), Expect = 3e-29 Identities = 99/299 (33%), Positives = 141/299 (47%), Gaps = 11/299 (3%) Query: 5 VPLLLPLLLLL---ALGPGV--QGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYV 59 +PL LLLL+ A G G+ GCPS C CS+ V CT + VP +P + + L + Sbjct: 1 MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI 60 Query: 60 FENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNET 119 IT L+ F + L L + +N+++ + G F+ L +L L L N+L + Sbjct: 61 LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL 120 Query: 120 FRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDL 176 F+GL LE L L N++ IQP F L EL+L N L +P L L L+L Sbjct: 121 FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL 180 Query: 177 SHNSLLALEPGILD-TANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-V 234 NSL + P + N++ LRL L + G F L NL +L + NQ+ + P + Sbjct: 181 GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL 240 Query: 235 IRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLL 293 L RL L+ N I+QL P L L L + SL+ L + G P LR L Sbjct: 241 FHNNHNLQRLYLS-NNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 298 Score = 100 bits (248), Expect = 6e-21 Identities = 101/365 (27%), Positives = 155/365 (42%), Gaps = 44/365 (12%) Query: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116 L ++EN +T + G+F GL LQ L L QNQI L G+F NL L L+ N + ++ Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261 Query: 117 NETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLL 173 F L +L RL L N ++ + G F + L EL L DN + +LP L +L + Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321 Query: 174 LDLSHNSLLALEPGILD-TANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP 232 L LS N + + PG + + L L LQ LD +F L NL ++ + +N+L ++P Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381 Query: 233 PVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 GN A + L + + N L+ LP G+F L Sbjct: 382 ---------------GNI---------FANVNGLMAIQLQNNQLENLP---LGIFDHLGK 414 Query: 293 LAAAR---NPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF-- 347 L R NP+ C + W+ + L + C P G+ L+ ++ Sbjct: 415 LCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVP 474 Query: 348 -----GCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGP 402 P+ T P T P + T++SS+ T SP E T+ + T +V Sbjct: 475 SVHVPEVPSYPETPWYPDT-PSYPDTTSVSSTTELT--SPVEDYTDLTTIQVTDDRSVWG 531 Query: 403 VPQPQ 407 + Q Q Sbjct: 532 MTQAQ 536 Score = 72.0 bits (175), Expect = 2e-12 Identities = 39/113 (34%), Positives = 63/113 (55%) Query: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR 111 P+ L++++N I+ L F+ L LQ+L LS+NQI+ + G F L L L L N Sbjct: 293 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA 352 Query: 112 LHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP 164 L ++ FR L L+ + L NR+R + F ++ L+ ++LQ+N+L LP Sbjct: 353 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405 Score = 70.9 bits (172), Expect = 4e-12 Identities = 49/142 (34%), Positives = 67/142 (47%), Gaps = 3/142 (2%) Query: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR 111 P L +F N + L G F +P L+ L L N I+SLP VF L L L L+ N+ Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328 Query: 112 LHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRL 168 + I+ F GL L L L N ++ + F L L + LQ+N LR LP + Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388 Query: 169 PRLLLLDLSHNSLLALEPGILD 190 L+ + L +N L L GI D Sbjct: 389 NGLMAIQLQNNQLENLPLGIFD 410 >gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] Length = 420 Score = 127 bits (318), Expect = 4e-29 Identities = 124/384 (32%), Positives = 161/384 (41%), Gaps = 62/384 (16%) Query: 11 LLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDA 69 LL+LLAL CP C C S P TV C A ++VP +PP T L++ N I L Sbjct: 18 LLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRP 77 Query: 70 GSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERL 129 G+F +NL L L +N L I TFR L+ LE L Sbjct: 78 GTFG--------------------------SNLLTLWLFSNNLSTIYPGTFRHLQALEEL 111 Query: 130 YLGKNR-IRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHNSLLALE 185 LG NR +R ++P F L+RL L L +L +LP L L L L NSLL L+ Sbjct: 112 DLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQ 171 Query: 186 PGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRL 244 + D AN+ L L G L+ L E +F RGL L RL Sbjct: 172 DDLFADLANLSHLFLHGNRLRLLTEHVF-----------------------RGLGSLDRL 208 Query: 245 RLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVC 304 L GN R+ + GL+ L L + N SL +LPG+ P L L NP+ C C Sbjct: 209 LLHGN-RLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDC 267 Query: 305 PLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADF-GCPATTTTATVPTTRP 363 W + + V S + C PP+ GR L L ADF CP T P +R Sbjct: 268 RARPLWAWFQRARV---SSSDVTCATPPERQGRDLRALREADFQACPPAAPTR--PGSRA 322 Query: 364 VVREPTALSSSLAPTWLSPTEPAT 387 + +A P +P+T Sbjct: 323 RGNSSSNHLYGVAEAGAPPADPST 346 >gi|4758460 glycoprotein V (platelet) [Homo sapiens] Length = 560 Score = 125 bits (314), Expect = 1e-28 Identities = 114/373 (30%), Positives = 153/373 (41%), Gaps = 55/373 (14%) Query: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120 +N + L A F L L+LLDLS N + LP G+ A L L L +NRL + + Sbjct: 155 QNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLL 214 Query: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLS 177 L L L +N IR I PGAFD L L L L N L LP L L LL L Sbjct: 215 NSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLF 274 Query: 178 HNSLLALEPGIL-----------------------DTANVEALRLAGL----GLQQLDEG 210 N L L PG+L N+ LR G+ L L +G Sbjct: 275 ENPLAEL-PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQG 333 Query: 211 LFSRLRNLHDLDVSDNQLERVPP-VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQEL 269 F L L L + N L +P ++RGL L ++ L N R+ L L++L+ + Sbjct: 334 AFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN-RLRALPRALFRNLSSLESV 392 Query: 270 DVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCH 329 + + L+ LPGD+ G PRL + N + C C L F W+R+ + E RC Sbjct: 393 QLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCA 452 Query: 330 FPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEA 389 P +AG L L D CP P RP + ++EA Sbjct: 453 GPGAHAGLPLWALPGGDAECPGPRG----PPPRPA------------------ADSSSEA 490 Query: 390 PSPPSTAPPTVGP 402 P P+ AP + P Sbjct: 491 PVHPALAPNSSEP 503 Score = 99.4 bits (246), Expect = 1e-20 Identities = 98/326 (30%), Positives = 137/326 (42%), Gaps = 33/326 (10%) Query: 4 RVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPR-DVPPDTVGLYVFEN 62 R LL +L LL P CP C+C C+ + +P + + +F Sbjct: 3 RGTLLCAVLGLLRAQPFP--CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM 60 Query: 63 GITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRG 122 G +L + SF+G+ LQ L +S + I+++ G F L L L L+ N++ + Sbjct: 61 GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120 Query: 123 LRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHN 179 + LE+L+L N +R I F L L EL L N+L LP L L LLDLS N Sbjct: 121 MVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN 180 Query: 180 SLLALEPGILDT-ANVEALRLAGLGLQQLDEGL------------------------FSR 214 +L L G+L A +E L L L LD GL F R Sbjct: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240 Query: 215 LRNLHDLDVSDNQLERVPPVI-RGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSN 273 L NL L +S N L +P + LT L L N +A+L + LQEL ++ Sbjct: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENP-LAELPGVLFGEMGGLQELWLNR 299 Query: 274 LSLQALPGDLSGLFPRLRLLAAARNP 299 L+ LP RLR L +P Sbjct: 300 TQLRTLPAAAFRNLSRLRYLGVTLSP 325 Score = 50.4 bits (119), Expect = 5e-06 Identities = 27/81 (33%), Positives = 45/81 (55%) Query: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116 L + NG+T L G GL L+ + L +N++ +LP +F+ L++L ++ L N+L + Sbjct: 344 LALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403 Query: 117 NETFRGLRRLERLYLGKNRIR 137 + F L RL + LG N R Sbjct: 404 GDVFGALPRLTEVLLGHNSWR 424 >gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo sapiens] Length = 592 Score = 124 bits (310), Expect = 4e-28 Identities = 117/362 (32%), Positives = 154/362 (42%), Gaps = 57/362 (15%) Query: 2 CSRVPLLLPLLLLLALGPGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVF 60 C L LPLLLL A P GCP+ C+C+ Q + V CT R+ T VP +P +T L + Sbjct: 3 CWLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELS 62 Query: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIAS------------------------LPSGVF 96 N I L+ G A LP L+ LDLS+N IA +P GVF Sbjct: 63 RNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVF 122 Query: 97 QPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQ 156 L NL+ LDL+ N+L + + TF+ L L RL +G N + + AF L L EL L+ Sbjct: 123 TRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE 182 Query: 157 D-----------NELRALPPLRLPRLLLLDLSHNSLLALEPGILD--------TANVEAL 197 LR+L LRL L + L + L PG+L V A Sbjct: 183 RCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRL-PGLLHLEIDNWPLLEEVAAG 241 Query: 198 RLAGLGLQQLD----------EGLFSRLRNLHDLDVSDNQLERVP-PVIRGLRGLTRLRL 246 L GL L L +L L++S N + VP R L L L L Sbjct: 242 SLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHL 301 Query: 247 AGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPL 306 AG +A + P+ GL ++ L++SN L L L L NP C C L Sbjct: 302 AG-ALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRL 360 Query: 307 SW 308 W Sbjct: 361 LW 362 >gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo sapiens] Length = 660 Score = 120 bits (301), Expect = 4e-27 Identities = 155/601 (25%), Positives = 245/601 (40%), Gaps = 99/601 (16%) Query: 24 CPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLD- 82 CPS C+C + V+C R T+VP +P LY+ N I +AG A L +Q + Sbjct: 36 CPSVCRCDR-NFVYCNERSLTSVPLGIPEGVTVLYLHNNQIN--NAGFPAELHNVQSVHT 92 Query: 83 --LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHI- 139 L NQ+ P + + N+ L L N + I+ L +LE L+L N I + Sbjct: 93 VYLYGNQLDEFPMNLPK---NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG 149 Query: 140 -QPGAFDTLDRLLELKLQDNELRALP---PLRLPRL--------LLLDLSHNSLLALEPG 187 + GAF L L L N L ++P P+ L L ++ D++ +L +LE Sbjct: 150 VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209 Query: 188 ILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLA 247 I+D N+ L + + EG FS L L + + N L PP + G L RL L Sbjct: 210 IVD-GNL-------LTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTH-LIRLYLQ 260 Query: 248 GNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLS 307 N +I + + L L+ LD+SN L+ L + L+ L A NP+ C C + Sbjct: 261 DN-QINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319 Query: 308 WFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVRE 367 W W++ +L + C P + G + EL+ CP TTT +P P Sbjct: 320 WVTEWLKYIPSSL-NVRGFMCQGPEQVRGMAVRELNMNLLSCP--TTTPGLPLFTP---- 372 Query: 368 PTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVG-PVPQPQDCPPSTCLNGGTCHLGTRH 426 AP+ SPT T PPT+ P P PP+ T L T Sbjct: 373 --------APSTASPT-----------TQPPTLSIPNPSRSYTPPTPT----TSKLPT-- 407 Query: 427 HLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQG 486 P+ VTP + L I V+ TS++V Sbjct: 408 -----IPDW---------------DGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTV 447 Query: 487 SSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEY-TVTQLRPNATYSVCVMPLGPGRVPE 545 + +L +++ + + G +V R+ + ++ ++ L P +TY +C++PL Sbjct: 448 MAYKLTWVKMGHSLVGG----IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRA 503 Query: 546 GEEA-CGEAHTPPA-------VHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAY 597 E+ C EA T + S+H T G+ P L+A + ++ L + + + Sbjct: 504 VEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGS-PFLLAGLIGGAVIFVLVVLLSVF 562 Query: 598 C 598 C Sbjct: 563 C 563 >gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] Length = 713 Score = 120 bits (301), Expect = 4e-27 Identities = 111/400 (27%), Positives = 155/400 (38%), Gaps = 76/400 (19%) Query: 7 LLLPLLLLLALG--------PGVQGCPSGCQCS------------QPQTVFCTARQGTTV 46 L+ PLLL G P CP C C + TV C T V Sbjct: 4 LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63 Query: 47 PRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLD 106 P +P T L + N I +D L L LDLSQN + F L L +L Sbjct: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123 Query: 107 LTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPL 166 L N+L + + +F GL L+ LYL N++ I P AF L LL L L N LRA+ Sbjct: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183 Query: 167 ---RLPRLLLLDLSHNSLLA-LEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLD 222 LP L +L + N + A L+ AN+ +L LAG+ L+++ + L++L L Sbjct: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243 Query: 223 VSDNQLERVP------------------PVIR---------------------------- 236 DNQL RVP P+ R Sbjct: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303 Query: 237 ----GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 L LT+L + N R++ + P L ++ L ++N +L AL P L+ Sbjct: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363 Query: 293 LAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPP 332 + NP C C + W + V P+ T C PP Sbjct: 364 VGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQSTLCAEPP 401 >gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] Length = 713 Score = 120 bits (301), Expect = 4e-27 Identities = 111/400 (27%), Positives = 155/400 (38%), Gaps = 76/400 (19%) Query: 7 LLLPLLLLLALG--------PGVQGCPSGCQCS------------QPQTVFCTARQGTTV 46 L+ PLLL G P CP C C + TV C T V Sbjct: 4 LVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAV 63 Query: 47 PRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLD 106 P +P T L + N I +D L L LDLSQN + F L L +L Sbjct: 64 PPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLH 123 Query: 107 LTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPL 166 L N+L + + +F GL L+ LYL N++ I P AF L LL L L N LRA+ Sbjct: 124 LEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSR 183 Query: 167 ---RLPRLLLLDLSHNSLLA-LEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLD 222 LP L +L + N + A L+ AN+ +L LAG+ L+++ + L++L L Sbjct: 184 WFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLS 243 Query: 223 VSDNQLERVP------------------PVIR---------------------------- 236 DNQL RVP P+ R Sbjct: 244 FYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDK 303 Query: 237 ----GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 L LT+L + N R++ + P L ++ L ++N +L AL P L+ Sbjct: 304 FALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363 Query: 293 LAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPP 332 + NP C C + W + V P+ T C PP Sbjct: 364 VGLHGNPIRCDCVIRWAN--ATGTRVRFIEPQSTLCAEPP 401 >gi|198041768 synleurin [Homo sapiens] Length = 622 Score = 119 bits (298), Expect = 9e-27 Identities = 113/421 (26%), Positives = 174/421 (41%), Gaps = 63/421 (14%) Query: 2 CSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFE 61 C R+ L++ LLL L + GC S CQ + + C +++P++ P TV LY+ Sbjct: 10 CLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTG 69 Query: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121 N I+ ++ GL L L L + I + F L +L L L N + + F+ Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129 Query: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSH 178 GL L LYL N++ + G F+ L + L LQ N L L + + L +LDLS+ Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189 Query: 179 NSLLAL-EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIR 236 N++L + E G N+ L L L ++ F L++L L +S N +E + P + Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249 Query: 237 GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGD-------------- 282 GL L L L N+RI + + +G+ L+ L +S+ L+ L D Sbjct: 250 GLANLEYL-LLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLD 308 Query: 283 ----------------------------LSGLFPR-------LRLLAAARNPFNCVCPLS 307 L+ L PR L L A NP+ C C L Sbjct: 309 RNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLL 368 Query: 308 WFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVRE 367 W+ S +TL C PP GR L ++ + T++ V VV+ Sbjct: 369 GLRDWLASSAITL----NIYCQNPPSMRGRALRYINITN----CVTSSINVSRAWAVVKS 420 Query: 368 P 368 P Sbjct: 421 P 421 >gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo sapiens] Length = 593 Score = 117 bits (294), Expect = 3e-26 Identities = 113/358 (31%), Positives = 150/358 (41%), Gaps = 64/358 (17%) Query: 10 PLLLLLALGPGVQG-CPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITML 67 PLL LL L G G CP+ C C SQPQ V C RQ VP +P DT L + N + L Sbjct: 16 PLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGL 75 Query: 68 DAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRL- 126 G + L LQ LDLS NQ+++L G F L +L L L NRL + F GL L Sbjct: 76 QQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALT 135 Query: 127 -----------------------ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRAL 163 ++L +G N + + PGAF L +L L L+ L + Sbjct: 136 LLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTV 195 Query: 164 PPL---RLPRLLLLDLSH-------------------------NSLLALEPGILDTANVE 195 P L RLP L+ L L SL AL+PG L N+ Sbjct: 196 PGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLS 255 Query: 196 ALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-----PVIRGLRGLTRLRLAGNT 250 +L + L + L L LD+S N + +P P++R L LRL+G Sbjct: 256 SLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVR----LQELRLSGAC 311 Query: 251 RIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSW 308 + + GL A LDV++ +LQ L +L L + NP C C L W Sbjct: 312 -LTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLW 368 Score = 54.7 bits (130), Expect = 3e-07 Identities = 45/136 (33%), Positives = 64/136 (47%), Gaps = 9/136 (6%) Query: 51 PPDTVGLYVFENGITMLDAGSFA-----GLPGLQLLDLSQNQIASLPSGVFQPLANLSNL 105 P VGL + IT + S L L++LDLSQN I+++P+ PL L L Sbjct: 246 PGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQEL 305 Query: 106 DLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNEL----R 161 L+ L I F GL L + N ++ ++ AF + D+L+ L+L N L R Sbjct: 306 RLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCR 365 Query: 162 ALPPLRLPRLLLLDLS 177 L LRL R L +S Sbjct: 366 LLWLLRLRRHLDFGMS 381 >gi|153251229 chondroadherin precursor [Homo sapiens] Length = 359 Score = 115 bits (289), Expect = 1e-25 Identities = 102/346 (29%), Positives = 144/346 (41%), Gaps = 13/346 (3%) Query: 4 RVPLLLPLLLLLALGPGVQGCPSGCQC-SQPQTVFCTARQGTTVPRDVPPDTVGLYVFEN 62 R LLL L LL L P + CP C C S Q V C +P+ V T L + N Sbjct: 3 RPMLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRN 61 Query: 63 GITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRG 122 +L A SF +P L L L QI + +G F+ L L L L+ N + + F Sbjct: 62 NFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDD 121 Query: 123 LRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDN---ELRALPPLRLPRLLLLDLSHN 179 L L LYL N++ + G L L L+L +N ELRA L L LS N Sbjct: 122 LTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSEN 181 Query: 180 SLLALEPGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIRG 237 +L +L+PG L D N+ + L S+LR + +L +S N L+ +P + Sbjct: 182 ALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQS 241 Query: 238 LRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAAR 297 NT + + G+ L+ + + N L LP + F L LA Sbjct: 242 FGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNFP--FDSLETLALTN 299 Query: 298 NPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELD 343 NP+ C C L W+ AS + C P K G+ + + D Sbjct: 300 NPWKCTCQLRGLRRWLEAK----ASRPDATCASPAKFKGQHIRDTD 341 >gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] Length = 545 Score = 112 bits (280), Expect = 1e-24 Identities = 93/300 (31%), Positives = 135/300 (45%), Gaps = 29/300 (9%) Query: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116 L + +N + L F L LQ L LS N ++ LP GVF L +L L L +N + E+ Sbjct: 174 LNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP 233 Query: 117 NETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLL 173 + F L LERL+L +N I H+ F +L L L LQ N LR LP P L+ Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVG 293 Query: 174 LDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP 233 L L+HN L + + EG F+ L NL L +S N + +P Sbjct: 294 LSLTHNQL-----------------------ETVAEGTFAHLSNLRSLMLSYNAITHLPA 330 Query: 234 -VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 + R L L +L L G+ + L P L+ L+ L +S L LP + L Sbjct: 331 GIFRDLEELVKLYL-GSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389 Query: 293 LAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPAT 352 LA NP+ C C L++ W+++ L + +T C P G+++ L+ CP T Sbjct: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTYCAGPAYLKGQVVPALNEKQLVCPVT 448 Score = 111 bits (278), Expect = 2e-24 Identities = 91/295 (30%), Positives = 129/295 (43%), Gaps = 7/295 (2%) Query: 14 LLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFA 73 LL L Q CP GC C Q VFC+ + TVP D+PP T + E T L+ +F Sbjct: 12 LLLLARPAQPCPMGCDCFV-QEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFG 70 Query: 74 GLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGK 133 P L + Q+ F L L +L++T + ++ F L L +L L Sbjct: 71 SNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNF 130 Query: 134 NRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHNSLLALEPGIL- 189 N + + G F L L L LQ N+L+ALP L L L+L+ N L L + Sbjct: 131 NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFH 190 Query: 190 DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPP-VIRGLRGLTRLRLAG 248 +++ L+L+ L L +G+F +L +L +L + N + +PP V L L RL L Sbjct: 191 PLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQR 250 Query: 249 NTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCV 303 N I L A L L L + L+ LP L P L L+ N V Sbjct: 251 NA-ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304 Score = 66.2 bits (160), Expect = 9e-11 Identities = 41/107 (38%), Positives = 56/107 (52%) Query: 52 PDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANR 111 P VGL + N + + G+FA L L+ L LS N I LP+G+F+ L L L L +N Sbjct: 289 PCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNN 348 Query: 112 LHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDN 158 L + F+ L +LE L L KN++ + G FDT L L L N Sbjct: 349 LTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395 >gi|229089140 leucine rich repeat containing 24 [Homo sapiens] Length = 513 Score = 111 bits (278), Expect = 2e-24 Identities = 79/203 (38%), Positives = 106/203 (52%), Gaps = 6/203 (2%) Query: 1 MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF 60 M R P LLPLLLLL L GCP+ C+C TV C A + VP +PP T L++ Sbjct: 1 MALRAPALLPLLLLL-LPLRAAGCPAACRCYSA-TVECGALRLRVVPLGIPPGTQTLFLQ 58 Query: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120 +N I L+ G+ A L L+ L L N + +L +G F+ L L LT+NRL + + F Sbjct: 59 DNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAF 118 Query: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLS 177 GL +L LYL N++ + F L RL EL LQ+N + L L L LLDLS Sbjct: 119 VGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLS 178 Query: 178 HNSLLALEPGILD-TANVEALRL 199 N L + L A+++ LRL Sbjct: 179 RNQLGTISREALQPLASLQVLRL 201 Score = 33.5 bits (75), Expect = 0.66 Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 2/69 (2%) Query: 230 RVPPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPR 289 RV P+ G+ T+ + IA+L P LA LAAL+ L + N SL+AL PR Sbjct: 42 RVVPL--GIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPR 99 Query: 290 LRLLAAARN 298 L LA N Sbjct: 100 LLELALTSN 108 >gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo sapiens] Length = 581 Score = 108 bits (271), Expect = 1e-23 Identities = 110/423 (26%), Positives = 181/423 (42%), Gaps = 73/423 (17%) Query: 7 LLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGL--------- 57 ++ P +LL L +GCP GC+C + + V+C +++ +P + +GL Sbjct: 17 VIAPTVLLTMLSSAERGCPKGCRC-EGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQK 75 Query: 58 ---------------YVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANL 102 Y+ N I+ +D +F G+ L+ L LS N+I+ + F+P+ NL Sbjct: 76 LKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNL 135 Query: 103 SNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRA 162 NLDL+ N+LH + +E FRGLR+L L+L N +R I F L L L N +R+ Sbjct: 136 RNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRS 195 Query: 163 LPP---LRLPRLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLH 219 L + RL L L HN +L+ LF RL +L Sbjct: 196 LARNVFAGMIRLKELHLEHNQ-----------------------FSKLNLALFPRLVSLQ 232 Query: 220 DLDVSDNQLERVPPVIRGL-RGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQA 278 +L + N++ + + L RL L+GN A P + LQ L++ + L Sbjct: 233 NLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTF 292 Query: 279 LPGDLSGLFPRLRLLAAARNPFNC---VCPL-SWFGPW--VRESHVTLASPEETRCHFPP 332 + ++ + L ++ A N + C +C L +W + +RE+ + ASP+E + Sbjct: 293 IGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQ----- 347 Query: 333 KNAGRLLLELDYADFGCPATTT-------TATVPTTRPVVREPTALSSSLAPTWLSPTEP 385 G +++ C +TT PT +P + P S P + TEP Sbjct: 348 ---GVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEP 404 Query: 386 ATE 388 E Sbjct: 405 GPE 407 >gi|38202222 fibronectin leucine rich transmembrane protein 3 precursor [Homo sapiens] Length = 649 Score = 108 bits (271), Expect = 1e-23 Identities = 145/594 (24%), Positives = 241/594 (40%), Gaps = 96/594 (16%) Query: 22 QGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLL 81 + CPS C+C ++C R T++P +P D LY+ N I +AG + L L + Sbjct: 29 KSCPSVCRCDAG-FIYCNDRFLTSIPTGIPEDATTLYLQNNQIN--NAGIPSDLKNLLKV 85 Query: 82 D---LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR- 137 + L N + P+ + + + L L N + IT ++ + LE L+L N + Sbjct: 86 ERIYLYHNSLDEFPTNLPK---YVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSA 142 Query: 138 -HIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLL-LDLSHNSLLALE-PGILDTANV 194 I+ GAF + L L L N L +P LPR + L L N + + P + ++ Sbjct: 143 VSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLDDNRISTISSPSLQGLTSL 201 Query: 195 EALRLAG--LGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTRI 252 + L L G L L + +F L NL +L + N L P + G L +L L N I Sbjct: 202 KRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTN-LRKLYLQDN-HI 259 Query: 253 AQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPW 312 ++ P + L L LD+SN +L LP + + L NP+ C C + W W Sbjct: 260 NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDW 319 Query: 313 VRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALS 372 ++ V + + C P K G + +L+ F C + +T+ T TA+ Sbjct: 320 LQSLPVKV-NVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQIT-------TAIP 371 Query: 373 SSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTCHLGTRHHLACLC 432 +++ P P T+ P + P+ T+ H Sbjct: 372 NTVYPAQGQWPAPVTKQPD-----------IKNPK---------------LTKDH----- 400 Query: 433 PEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQGSSVQLR 492 T SP+ T +T+ ++ V+ ++ + + L ++++L Sbjct: 401 ---------------QTTGSPSRKT------ITITVKSVTSDTIHISWKLALPMTALRLS 439 Query: 493 SLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEE--AC 550 L+L + G + + +EY VT L P++ Y VC++P+ + +E C Sbjct: 440 WLKLGHSPAFGSITETI---VTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVC 496 Query: 551 GEAHTPPAVHSNHAPVTQA---------REGNLPL--LIAPALAAVLLAALAAV 593 E T P N P T + NLPL +I A+A V +A LA V Sbjct: 497 IETETAPLRMYN--PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALV 548 >gi|7019383 fibronectin leucine rich transmembrane protein 3 precursor [Homo sapiens] Length = 649 Score = 108 bits (271), Expect = 1e-23 Identities = 145/594 (24%), Positives = 241/594 (40%), Gaps = 96/594 (16%) Query: 22 QGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLL 81 + CPS C+C ++C R T++P +P D LY+ N I +AG + L L + Sbjct: 29 KSCPSVCRCDAG-FIYCNDRFLTSIPTGIPEDATTLYLQNNQIN--NAGIPSDLKNLLKV 85 Query: 82 D---LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR- 137 + L N + P+ + + + L L N + IT ++ + LE L+L N + Sbjct: 86 ERIYLYHNSLDEFPTNLPK---YVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSA 142 Query: 138 -HIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLL-LDLSHNSLLALE-PGILDTANV 194 I+ GAF + L L L N L +P LPR + L L N + + P + ++ Sbjct: 143 VSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLDDNRISTISSPSLQGLTSL 201 Query: 195 EALRLAG--LGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTRI 252 + L L G L L + +F L NL +L + N L P + G L +L L N I Sbjct: 202 KRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTN-LRKLYLQDN-HI 259 Query: 253 AQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPW 312 ++ P + L L LD+SN +L LP + + L NP+ C C + W W Sbjct: 260 NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDW 319 Query: 313 VRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALS 372 ++ V + + C P K G + +L+ F C + +T+ T TA+ Sbjct: 320 LQSLPVKV-NVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQIT-------TAIP 371 Query: 373 SSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTCHLGTRHHLACLC 432 +++ P P T+ P + P+ T+ H Sbjct: 372 NTVYPAQGQWPAPVTKQPD-----------IKNPK---------------LTKDH----- 400 Query: 433 PEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQGSSVQLR 492 T SP+ T +T+ ++ V+ ++ + + L ++++L Sbjct: 401 ---------------QTTGSPSRKT------ITITVKSVTSDTIHISWKLALPMTALRLS 439 Query: 493 SLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEE--AC 550 L+L + G + + +EY VT L P++ Y VC++P+ + +E C Sbjct: 440 WLKLGHSPAFGSITETI---VTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVC 496 Query: 551 GEAHTPPAVHSNHAPVTQA---------REGNLPL--LIAPALAAVLLAALAAV 593 E T P N P T + NLPL +I A+A V +A LA V Sbjct: 497 IETETAPLRMYN--PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALV 548 >gi|13375646 leucine rich repeat and fibronectin type III domain containing 3 [Homo sapiens] Length = 628 Score = 108 bits (270), Expect = 2e-23 Identities = 161/661 (24%), Positives = 220/661 (33%), Gaps = 114/661 (17%) Query: 8 LLPLLL-LLALGPGVQG--------CPSGCQC---SQPQTVFCTARQGTTVPRDVPPDTV 55 +LPLLL LL L P CP C+C S P +V C VP + Sbjct: 3 ILPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAA 62 Query: 56 GLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEI 115 L + +N I + A + GL L LS+N I + +G F L L L L NRL + Sbjct: 63 ELRLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSL 122 Query: 116 TNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLE-LKLQDNELRALPPLRLPRLLLL 174 RGL L L L N++ + GA D LE L L N L LP L RL Sbjct: 123 GEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRL--- 179 Query: 175 DLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPV 234 NV L L L + G FSRL L LD++ N+L +PP Sbjct: 180 -----------------GNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPP- 221 Query: 235 IRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLA 294 + S L L A P G +LA Sbjct: 222 ---------------------------------DPLFSRLPLLARP---RGSPASALVLA 245 Query: 295 AARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTT 354 NP +C C L W RE + C PP GR + +F C Sbjct: 246 FGGNPLHCNCELVWLRRLAREDDL-------EACASPPALGGRYFWAVGEEEFVCEPPVV 298 Query: 355 T-----ATVPTTRPVVREPTALSS-SLAPTWLSPTEPATEAPSPPSTAPPTVGP--VPQP 406 T VP RP A+ W+SP S P V +P Sbjct: 299 THRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTEP 358 Query: 407 QDCPPSTCLNGGTCHLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTL 466 D TC+ T + P L + P +TP S + Sbjct: 359 GDGGIFTCIAANAAGEATAAVELTVGPPPPPQLANSTSCDPPRDGDPDALTPPSAASASA 418 Query: 467 GIEPVSPTSLRVGLQRYLQGSSVQL------------RSLRLTYRNLSGPDKRLVTLRLP 514 + P + R G+Q G++ L R ++ Y S D LV +P Sbjct: 419 KVADTGPPTDR-GVQVTEHGATAALVQWPDQRPIPGIRMYQIQYN--SSADDILVYRMIP 475 Query: 515 ASLAEYTVTQLRPNATYSVCVMPL----GPGRVPEGEEACGEAHTPPAVHSNHAPVTQAR 570 A + +T L TY +CV+ + G C T PA+ AP Sbjct: 476 AESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCARFSTEPALRPCGAPHAPFL 535 Query: 571 EGNLPLLIAPALAAVLLAALAAVGAAYCVRRGR----------AMAAAAQDKGQVGPGAG 620 G + + + + A +L + + Y V G+ + +Q G +GP Sbjct: 536 GGTMIIALGGVIVASVLVFIFVLLMRYKVHGGQPPGKAKIPAPVSSVCSQTNGALGPTPT 595 Query: 621 P 621 P Sbjct: 596 P 596 >gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens] Length = 1065 Score = 108 bits (269), Expect = 2e-23 Identities = 83/293 (28%), Positives = 134/293 (45%), Gaps = 30/293 (10%) Query: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121 N I +++ +F GL L+ L + +N I+ L G F L N+ L+L N L + Sbjct: 225 NRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLY 284 Query: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSL 181 GLR L++LY+ +N I I P A++ RL E LDLS+N L Sbjct: 285 GLRMLQQLYVSQNAIERISPDAWEFCQRLSE---------------------LDLSYNQL 323 Query: 182 LAL-EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQ----LERVPPVIR 236 L E + + +E L L + + +G+F L NL LD+ +N+ +E Sbjct: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFA 383 Query: 237 GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAA 296 GL LT+L L GN +I + + GL +L+ LD++N ++ ++ + L+ L Sbjct: 384 GLTSLTKLILQGN-QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ-THLKELILN 441 Query: 297 RNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGC 349 + C C L W W+ +++ C P AG+ +L +D DF C Sbjct: 442 TSSLLCDCHLKWLLQWLVDNN--FQHSVNVSCAHPEWLAGQSILNVDLKDFVC 492 Score = 86.3 bits (212), Expect = 9e-17 Identities = 86/300 (28%), Positives = 138/300 (46%), Gaps = 36/300 (12%) Query: 11 LLLLLALGPGVQGCPSGCQCSQPQTVFCTARQ-----GTTVPRDVPPDTVGLYVFENGIT 65 LLLL A G G+ CP+ C C P + C+ R+ + +PPDT L N ++ Sbjct: 32 LLLLPAAGAGL--CPAPCSCRIP-LLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLS 88 Query: 66 --------------MLDAGSFAGLP-------GLQLLDLSQNQIASLPSGVFQPLANLSN 104 ++ +P + LL L N I + + Q L + Sbjct: 89 NWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALES 148 Query: 105 LDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTL-DRLLELKLQDNELRAL 163 LDL++N + EI +F + +L+ L L NRI ++ G FD L LL +KL N + + Sbjct: 149 LDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMI 207 Query: 164 PP--LRLPRLLLLDLSHNSLLALEP-GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHD 220 PP +LP L L+L N + +E ++ +L++ G+ +L +G F L N+ + Sbjct: 208 PPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEE 267 Query: 221 LDVSDNQLERV-PPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQAL 279 L++ N L RV + GLR L +L ++ N I ++ P+ L ELD+S L L Sbjct: 268 LELEHNNLTRVNKGWLYGLRMLQQLYVSQNA-IERISPDAWEFCQRLSELDLSYNQLTRL 326 Score = 58.2 bits (139), Expect = 2e-08 Identities = 45/149 (30%), Positives = 73/149 (48%), Gaps = 6/149 (4%) Query: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116 LYV +N I + ++ L LDLS NQ+ L F L+ L L+L NR+ I Sbjct: 292 LYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIA 351 Query: 117 NETFRGLRRLERLYLGKNRIR---HIQPGAFDTLDRLLELKLQDNELRALPP---LRLPR 170 + FR L L+ L L N I AF L L +L LQ N+++++ + L Sbjct: 352 DGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLES 411 Query: 171 LLLLDLSHNSLLALEPGILDTANVEALRL 199 L LDL++N++++++ +++ L L Sbjct: 412 LEHLDLNNNAIMSIQENAFSQTHLKELIL 440 >gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sapiens] Length = 516 Score = 107 bits (268), Expect = 3e-23 Identities = 109/373 (29%), Positives = 165/373 (44%), Gaps = 32/373 (8%) Query: 11 LLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAG 70 L +L ALG CP C+C + +C ++ +VP ++GL + N IT L+ Sbjct: 24 LKMLPALG---MACPPKCRCEK-LLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERD 79 Query: 71 SFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLY 130 FA L L L NQI+++ FQ L L L L++N++ + N TF L L+ L Sbjct: 80 QFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLD 139 Query: 131 LGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRL----PRLLLLDLSHNSLLAL-E 185 L N++ + P F L +L L L+ N LR + P+RL L LDLS N L +L Sbjct: 140 LSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI-PVRLFWDCRSLEFLDLSTNRLRSLAR 198 Query: 186 PGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG-LTRL 244 G + L L L +++ F RL +LH L + N++ + + G L +L Sbjct: 199 NGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKL 258 Query: 245 RLAGNTRIAQLRPEDLAGLAALQELDV---SNLSLQALPGDLSGLFPRLRLLAAARNPFN 301 L GN +++ DL + L + N L +L + L + + N + Sbjct: 259 DLTGN----EIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWE 314 Query: 302 C---VCPL-SWFGPWV-RESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTA 356 C +C L SW G + R H L CH P G +L+ + C +TT Sbjct: 315 CSARICALASWLGSFQGRWEHSIL-------CHSPDHTQGEDILDAVHGFQLCWNLSTTV 367 Query: 357 TVPTTRPVVREPT 369 TV T R+PT Sbjct: 368 TVMAT--TYRDPT 378 >gi|225579152 insulin-like growth factor binding protein, acid labile subunit isoform 1 precursor [Homo sapiens] Length = 643 Score = 107 bits (266), Expect = 5e-23 Identities = 112/373 (30%), Positives = 157/373 (42%), Gaps = 82/373 (21%) Query: 7 LLLPLLLL--LALGP--------GVQG------CPSGCQCSQPQ-----TVFCTARQGTT 45 L L LLLL +ALGP G G CP+ C CS +VFC++R T Sbjct: 46 LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTR 105 Query: 46 VPRDVPPDTVGLYVFENGIT---------------------------------------- 65 +P VP T L++ N ++ Sbjct: 106 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 165 Query: 66 --------MLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITN 117 L G+FA P L L LS N+++ L G+F+ L +L +L+L N L + + Sbjct: 166 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 225 Query: 118 ETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLL 174 FRGL L L L NR+ ++QP F L L EL L N LRA+ ++LPRL L Sbjct: 226 AAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKL 285 Query: 175 DLSHNSLLALEPGILDTANVEALRLAGLG---LQQLDEGLFSRLRNLHDLDVSDNQLERV 231 L N + A+ PG ++ALR L + L E F L L L +S N + + Sbjct: 286 YLDRNLIAAVAPGAF--LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343 Query: 232 -PPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRL 290 P + L L L+L G+ RI QL GL L+ L + + LQ + +G F L Sbjct: 344 RPRTFKDLHFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK---AGAFLGL 399 Query: 291 RLLAAARNPFNCV 303 +A NC+ Sbjct: 400 TNVAVMNLSGNCL 412 Score = 100 bits (249), Expect = 4e-21 Identities = 89/270 (32%), Positives = 128/270 (47%), Gaps = 26/270 (9%) Query: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121 N + L +F GL GL++L LS N IASL F+ L L L L NR+ ++ +F Sbjct: 314 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFE 373 Query: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSH 178 GL +LE L L N+++ ++ GAF L + + L N LR LP L +L L L Sbjct: 374 GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG 433 Query: 179 NSLLALEP-GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIR 236 + L + P + + L L GL ++E L L +LD++ NQL +P + + Sbjct: 434 SCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQ 493 Query: 237 GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAA 296 GL L L L+ N R+A+L + L L LDVS+ L+ALP L RLR L+ Sbjct: 494 GLGKLEYLLLSRN-RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 552 Query: 297 R--------------------NPFNCVCPL 306 NP++C CPL Sbjct: 553 NNSLRTFTPQPPGLERLWLEGNPWDCGCPL 582 Score = 92.0 bits (227), Expect = 2e-18 Identities = 74/204 (36%), Positives = 106/204 (51%), Gaps = 10/204 (4%) Query: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHNSLLA 183 + L+L N + + P AF L L L LQ +L +L P L L L L L N L + Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174 Query: 184 LEPGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPV-IRGLRGL 241 L G T + +L L+ L +L++GLF L +L DL++ N L +P RGL L Sbjct: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234 Query: 242 TRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFN 301 L LAGN R+A L+P +GLA L+ELD+S +L+A+ ++ PRL+ L RN Sbjct: 235 RELVLAGN-RLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 293 Query: 302 CVCPLSWFG----PWVRESHVTLA 321 V P ++ G W+ SH +A Sbjct: 294 AVAPGAFLGLKALRWLDLSHNRVA 317 >gi|4826772 insulin-like growth factor binding protein, acid labile subunit isoform 2 precursor [Homo sapiens] Length = 605 Score = 107 bits (266), Expect = 5e-23 Identities = 112/373 (30%), Positives = 157/373 (42%), Gaps = 82/373 (21%) Query: 7 LLLPLLLL--LALGP--------GVQG------CPSGCQCSQPQ-----TVFCTARQGTT 45 L L LLLL +ALGP G G CP+ C CS +VFC++R T Sbjct: 8 LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTR 67 Query: 46 VPRDVPPDTVGLYVFENGIT---------------------------------------- 65 +P VP T L++ N ++ Sbjct: 68 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 127 Query: 66 --------MLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITN 117 L G+FA P L L LS N+++ L G+F+ L +L +L+L N L + + Sbjct: 128 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 187 Query: 118 ETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLL 174 FRGL L L L NR+ ++QP F L L EL L N LRA+ ++LPRL L Sbjct: 188 AAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKL 247 Query: 175 DLSHNSLLALEPGILDTANVEALRLAGLG---LQQLDEGLFSRLRNLHDLDVSDNQLERV 231 L N + A+ PG ++ALR L + L E F L L L +S N + + Sbjct: 248 YLDRNLIAAVAPGAF--LGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305 Query: 232 -PPVIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRL 290 P + L L L+L G+ RI QL GL L+ L + + LQ + +G F L Sbjct: 306 RPRTFKDLHFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK---AGAFLGL 361 Query: 291 RLLAAARNPFNCV 303 +A NC+ Sbjct: 362 TNVAVMNLSGNCL 374 Score = 100 bits (249), Expect = 4e-21 Identities = 89/270 (32%), Positives = 128/270 (47%), Gaps = 26/270 (9%) Query: 62 NGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFR 121 N + L +F GL GL++L LS N IASL F+ L L L L NR+ ++ +F Sbjct: 276 NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFE 335 Query: 122 GLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSH 178 GL +LE L L N+++ ++ GAF L + + L N LR LP L +L L L Sbjct: 336 GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG 395 Query: 179 NSLLALEP-GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVP-PVIR 236 + L + P + + L L GL ++E L L +LD++ NQL +P + + Sbjct: 396 SCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQ 455 Query: 237 GLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAA 296 GL L L L+ N R+A+L + L L LDVS+ L+ALP L RLR L+ Sbjct: 456 GLGKLEYLLLSRN-RLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLR 514 Query: 297 R--------------------NPFNCVCPL 306 NP++C CPL Sbjct: 515 NNSLRTFTPQPPGLERLWLEGNPWDCGCPL 544 Score = 92.0 bits (227), Expect = 2e-18 Identities = 74/204 (36%), Positives = 106/204 (51%), Gaps = 10/204 (4%) Query: 127 ERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHNSLLA 183 + L+L N + + P AF L L L LQ +L +L P L L L L L N L + Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136 Query: 184 LEPGIL-DTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPV-IRGLRGL 241 L G T + +L L+ L +L++GLF L +L DL++ N L +P RGL L Sbjct: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196 Query: 242 TRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFN 301 L LAGN R+A L+P +GLA L+ELD+S +L+A+ ++ PRL+ L RN Sbjct: 197 RELVLAGN-RLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255 Query: 302 CVCPLSWFG----PWVRESHVTLA 321 V P ++ G W+ SH +A Sbjct: 256 AVAPGAFLGLKALRWLDLSHNRVA 279 >gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] Length = 708 Score = 106 bits (265), Expect = 6e-23 Identities = 138/614 (22%), Positives = 239/614 (38%), Gaps = 107/614 (17%) Query: 5 VPLLLPLLLLLALGPGVQG------CPSGCQCS------------QPQTVFCTARQGTTV 46 +PL + +LL LA+ VQ CP C C + TV C T Sbjct: 4 MPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTF 63 Query: 47 PRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLD 106 P +P +T L + N I ++ + + L LDLSQN ++S+ + + + L ++ Sbjct: 64 PARLPANTQILLLQTNNIAKIEYSTDFPV-NLTGLDLSQNNLSSVTNINVKKMPQLLSVY 122 Query: 107 LTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPL 166 L N+L E+ + L L+ LY+ N + I PGAF L LL L L N L+ + Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182 Query: 167 ---RLPRLLLLDLSHNSLLALEP-GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLD 222 LP L +L + N ++ ++ N+ +L +AG+ L ++ + L NL + Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242 Query: 223 VSDNQLERVP------------------PVIRGLRG------------------------ 240 DN+L +VP P+ R RG Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302 Query: 241 --------LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 L ++ N R++ + P L L+ L +++ +L AL P L+ Sbjct: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362 Query: 293 LAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPAT 352 ++ NP C C + W + ++++ P+ C PP+ G+ + ++ + D Sbjct: 363 ISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDM----- 415 Query: 353 TTTATVPTTRPVVREPTALSSSL---APTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDC 409 + P++ P + S+L A +++S AT P P P Q Sbjct: 416 -----MEICLPLI-APESFPSNLNVEAGSYVSFHCRATAEPQ-----PEIYWITPSGQKL 464 Query: 410 PPSTCLNGGTCHL-GTRHHLACLCPEGFTGLY---CESQMGQGTRPSPTPVTPRPPR--- 462 P+T + H GT EG GLY + +G + V P+ Sbjct: 465 LPNTLTDKFYVHSEGTLDINGVTPKEG--GLYTCIATNLVGADLKSVMIKVDGSFPQDNN 522 Query: 463 -SLTLGIEPVSPTSLRVGLQRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYT 521 SL + I + S+ V + S + S++ T + + R+P+ + Y Sbjct: 523 GSLNIKIRDIQANSVLVS---WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYN 579 Query: 522 VTQLRPNATYSVCV 535 +T L P+ Y +C+ Sbjct: 580 LTHLNPSTEYKICI 593 >gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] Length = 708 Score = 106 bits (265), Expect = 6e-23 Identities = 138/614 (22%), Positives = 239/614 (38%), Gaps = 107/614 (17%) Query: 5 VPLLLPLLLLLALGPGVQG------CPSGCQCS------------QPQTVFCTARQGTTV 46 +PL + +LL LA+ VQ CP C C + TV C T Sbjct: 4 MPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTF 63 Query: 47 PRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLD 106 P +P +T L + N I ++ + + L LDLSQN ++S+ + + + L ++ Sbjct: 64 PARLPANTQILLLQTNNIAKIEYSTDFPV-NLTGLDLSQNNLSSVTNINVKKMPQLLSVY 122 Query: 107 LTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPL 166 L N+L E+ + L L+ LY+ N + I PGAF L LL L L N L+ + Sbjct: 123 LEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSK 182 Query: 167 ---RLPRLLLLDLSHNSLLALEP-GILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLD 222 LP L +L + N ++ ++ N+ +L +AG+ L ++ + L NL + Sbjct: 183 WFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESIS 242 Query: 223 VSDNQLERVP------------------PVIRGLRG------------------------ 240 DN+L +VP P+ R RG Sbjct: 243 FYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDS 302 Query: 241 --------LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRL 292 L ++ N R++ + P L L+ L +++ +L AL P L+ Sbjct: 303 LAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKE 362 Query: 293 LAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPAT 352 ++ NP C C + W + ++++ P+ C PP+ G+ + ++ + D Sbjct: 363 ISIHSNPIRCDCVIRWMN--MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDM----- 415 Query: 353 TTTATVPTTRPVVREPTALSSSL---APTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDC 409 + P++ P + S+L A +++S AT P P P Q Sbjct: 416 -----MEICLPLI-APESFPSNLNVEAGSYVSFHCRATAEPQ-----PEIYWITPSGQKL 464 Query: 410 PPSTCLNGGTCHL-GTRHHLACLCPEGFTGLY---CESQMGQGTRPSPTPVTPRPPR--- 462 P+T + H GT EG GLY + +G + V P+ Sbjct: 465 LPNTLTDKFYVHSEGTLDINGVTPKEG--GLYTCIATNLVGADLKSVMIKVDGSFPQDNN 522 Query: 463 -SLTLGIEPVSPTSLRVGLQRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYT 521 SL + I + S+ V + S + S++ T + + R+P+ + Y Sbjct: 523 GSLNIKIRDIQANSVLVS---WKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYN 579 Query: 522 VTQLRPNATYSVCV 535 +T L P+ Y +C+ Sbjct: 580 LTHLNPSTEYKICI 593 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.137 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,770,411 Number of Sequences: 37866 Number of extensions: 1840077 Number of successful extensions: 19973 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 353 Number of HSP's successfully gapped in prelim test: 613 Number of HSP's that attempted gapping in prelim test: 11552 Number of HSP's gapped (non-prelim): 5277 length of query: 673 length of database: 18,247,518 effective HSP length: 109 effective length of query: 564 effective length of database: 14,120,124 effective search space: 7963749936 effective search space used: 7963749936 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.