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Search of human proteins with 88702791
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|88702791 mouse double minute 4 homolog [Homo sapiens]
(490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|88702791 mouse double minute 4 homolog [Homo sapiens] 998 0.0
gi|89993689 mouse double minute 2 homolog isoform MDM2 [Homo sap... 246 3e-65
gi|223890205 mouse double minute 2 homolog isoform MDM2h [Homo s... 233 4e-61
gi|223890201 mouse double minute 2 homolog isoform MDM2g [Homo s... 217 2e-56
gi|223890197 mouse double minute 2 homolog isoform MDM2f [Homo s... 165 8e-41
gi|223890207 mouse double minute 2 homolog isoform MDM2i [Homo s... 150 3e-36
gi|89993693 mouse double minute 2 homolog isoform MDM2d [Homo sa... 105 9e-23
gi|89993690 mouse double minute 2 homolog isoform MDM2a [Homo sa... 103 3e-22
gi|89993691 mouse double minute 2 homolog isoform MDM2e [Homo sa... 91 2e-18
gi|89993692 mouse double minute 2 homolog isoform MDM2b [Homo sa... 73 5e-13
gi|223278368 neuralized-like [Homo sapiens] 42 0.002
gi|34452686 ring finger protein, LIM domain interacting [Homo sa... 40 0.005
gi|34452684 ring finger protein, LIM domain interacting [Homo sa... 40 0.005
gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo sa... 40 0.006
gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo sap... 40 0.006
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap... 40 0.006
gi|30348954 mindbomb homolog 1 [Homo sapiens] 40 0.006
gi|217416388 neuralized homolog 1B [Homo sapiens] 39 0.011
gi|37595539 ring finger protein 34 isoform 1 [Homo sapiens] 39 0.011
gi|37595537 ring finger protein 34 isoform 2 [Homo sapiens] 39 0.011
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 38 0.024
gi|62865649 rififylin [Homo sapiens] 37 0.031
gi|17432433 rififylin [Homo sapiens] 37 0.031
gi|4505721 peroxisomal biogenesis factor 12 [Homo sapiens] 37 0.053
gi|214010238 mahogunin, ring finger 1 isoform 4 [Homo sapiens] 36 0.070
gi|214010236 mahogunin, ring finger 1 isoform 3 [Homo sapiens] 36 0.070
gi|214010234 mahogunin, ring finger 1 isoform 2 [Homo sapiens] 36 0.070
gi|44917608 mahogunin, ring finger 1 isoform 1 [Homo sapiens] 36 0.070
gi|171542821 mitochondrial ubiquitin ligase activator of NFKB 1 ... 36 0.070
gi|5174653 ring finger protein 6 [Homo sapiens] 35 0.20
>gi|88702791 mouse double minute 4 homolog [Homo sapiens]
Length = 490
Score = 998 bits (2580), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI 60
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
Sbjct: 1 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI 60
Query: 61 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL 120
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
Sbjct: 61 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL 120
Query: 121 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ 180
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
Sbjct: 121 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ 180
Query: 181 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF 240
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
Sbjct: 181 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF 240
Query: 241 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS 300
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
Sbjct: 241 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS 300
Query: 301 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP 360
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
Sbjct: 301 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP 360
Query: 361 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ 420
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
Sbjct: 361 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ 420
Query: 421 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE 480
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
Sbjct: 421 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE 480
Query: 481 IQLVIKVFIA 490
IQLVIKVFIA
Sbjct: 481 IQLVIKVFIA 490
>gi|89993689 mouse double minute 2 homolog isoform MDM2 [Homo
sapiens]
Length = 497
Score = 246 bits (629), Expect = 3e-65
Identities = 159/484 (32%), Positives = 256/484 (52%), Gaps = 44/484 (9%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 93
Query: 87 RQSFSVKDPSPLYDMLRKNLVTL-ATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESST 145
SFSVK+ +Y M+ +NLV + ++D+ +++ + H Q L Q +E
Sbjct: 94 VPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKP 153
Query: 146 SRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLD---LGFEEWDVAGLPWWF 202
S P+ + + E+ D + Q + + D L F+E +A
Sbjct: 154 SSSHLVSR--PSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDE-SLA------ 204
Query: 203 LGNLRSNYTPRSNG--STDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADT 260
L +R RS+ ST +N D+ + + D W +SVS+Q V +VE+ D+
Sbjct: 205 LCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD--WLDQDSVSDQFSVEFEVESLDS 262
Query: 261 E--QTSEEVGKVSDK-------KVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKK 311
E SEE ++SD+ V + G++D + S + D E++ D W+CT C +
Sbjct: 263 EDYSLSEEGQELSDEDDEVYQVTVYQAGESD------TDSFEEDPEISLADYWKCTSCNE 316
Query: 312 FNSPSKRYCFRCWALRKDWY-SDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPV 370
N P +C RCWALR++W D K +S + EG DVPDC++TI V
Sbjct: 317 MNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTI---V 373
Query: 371 VRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDC 430
+++ +++ + K+ S E D + S S I S E + +R +T++ E+
Sbjct: 374 NDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF--EREETQDKEES 431
Query: 431 ------QNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLV 484
N ++PC +C+ RP++G I+HG+TGHL+ CF CA++LKK CP+C++ IQ++
Sbjct: 432 VESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMI 491
Query: 485 IKVF 488
+ +
Sbjct: 492 VLTY 495
>gi|223890205 mouse double minute 2 homolog isoform MDM2h [Homo
sapiens]
Length = 442
Score = 233 bits (593), Expect = 4e-61
Identities = 154/478 (32%), Positives = 243/478 (50%), Gaps = 87/478 (18%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 93
Query: 87 RQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTS 146
SFSVK+ +Y M+ +NLV + +Q +++++E S
Sbjct: 94 VPSFSVKEHRKIYTMIYRNLVVV------------------------NQQEENSDELSGE 129
Query: 147 RKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNL 206
R+R R D I +L+ DE+ L + +
Sbjct: 130 RQR------------------KRHKSDSI-SLSFDESLALCV-----------------I 153
Query: 207 RSNYTPRSNGS--TDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQ-- 262
R RS+ S T +N D+ + + D W +SVS+Q V +VE+ D+E
Sbjct: 154 REICCERSSSSESTGTPSNPDLDAGVSEHSGD--WLDQDSVSDQFSVEFEVESLDSEDYS 211
Query: 263 TSEEVGKVSDKK-------VIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSP 315
SEE ++SD+ V + G++D + S + D E++ D W+CT C + N P
Sbjct: 212 LSEEGQELSDEDDEVYQVTVYQAGESD------TDSFEEDPEISLADYWKCTSCNEMNPP 265
Query: 316 SKRYCFRCWALRKDWY-SDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPK 374
+C RCWALR++W D K +S + EG DVPDC++TI V +
Sbjct: 266 LPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTI---VNDSR 322
Query: 375 DAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDT--ENMEDCQ- 431
++ +++ + K+ S E D + S S I S E + + T E++E
Sbjct: 323 ESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLP 382
Query: 432 -NLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
N ++PC +C+ RP++G I+HG+TGHL+ CF CA++LKK CP+C++ IQ+++ +
Sbjct: 383 LNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTY 440
>gi|223890201 mouse double minute 2 homolog isoform MDM2g [Homo
sapiens]
Length = 444
Score = 217 bits (553), Expect = 2e-56
Identities = 139/468 (29%), Positives = 226/468 (48%), Gaps = 59/468 (12%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 28 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 87
Query: 87 RQSFSVKDPSPLYDMLRKNLVTL-ATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESST 145
SFSVK+ +Y M+ +NLV + ++D+ +++ + H Q L Q +E
Sbjct: 88 VPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKP 147
Query: 146 SRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGN 205
S P+ + + E+ D + Q + + D
Sbjct: 148 SSSHLVSR--PSTSSRRRAISETEENSDELSGERQRKRHKSD------------------ 187
Query: 206 LRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSE 265
S L ++ + ++ + + S SE G T +
Sbjct: 188 -----------SISLSFDESLALCVIREICCE----RSSSSESTG---------TPSNPD 223
Query: 266 EVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWA 325
V V + G++D + S + D E++ D W+CT C + N P +C RCWA
Sbjct: 224 LDAGVYQVTVYQAGESD------TDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWA 277
Query: 326 LRKDWY-SDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSK 384
LR++W D K +S + EG DVPDC++TI V +++ +++ + K
Sbjct: 278 LRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDK 334
Query: 385 LFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLC 440
+ S E D + S S I S E + + T E++E N ++PC +C
Sbjct: 335 ITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVIC 394
Query: 441 EKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
+ RP++G I+HG+TGHL+ CF CA++LKK CP+C++ IQ+++ +
Sbjct: 395 QGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTY 442
>gi|223890197 mouse double minute 2 homolog isoform MDM2f [Homo
sapiens]
Length = 452
Score = 165 bits (418), Expect = 8e-41
Identities = 131/482 (27%), Positives = 218/482 (45%), Gaps = 85/482 (17%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KE
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKE----------------------------------- 58
Query: 87 RQSFSVKDPSPLYDMLRKNLVTL-ATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESST 145
+Y M+ +NLV + ++D+ +++ + H Q L Q +E
Sbjct: 59 ----------KIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKP 108
Query: 146 SRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLD---LGFEEWDVAGLPWWF 202
S P+ + + E+ D + Q + + D L F+E +A
Sbjct: 109 SSSHLVSR--PSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDE-SLA------ 159
Query: 203 LGNLRSNYTPRSNGS--TDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADT 260
L +R RS+ S T +N D+ + + D W +SVS+Q V +VE+ D+
Sbjct: 160 LCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD--WLDQDSVSDQFSVEFEVESLDS 217
Query: 261 EQ--TSEEVGKVSDKK-------VIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKK 311
E SEE ++SD+ V + G++D + S + D E++ D W+CT C +
Sbjct: 218 EDYSLSEEGQELSDEDDEVYQVTVYQAGESD------TDSFEEDPEISLADYWKCTSCNE 271
Query: 312 FNSPSKRYCFRCWALRKDWY-SDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPV 370
N P +C RCWALR++W D K +S + EG DVPDC++TI V
Sbjct: 272 MNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTI---V 328
Query: 371 VRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDT--ENME 428
+++ +++ + K+ S E D + S S I S E + + T E++E
Sbjct: 329 NDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVE 388
Query: 429 DCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIK 486
N ++PC +C+ RP++G I+HG+TGHL+ CF CA++LKK CP+C++ IQ+++
Sbjct: 389 SSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVL 448
Query: 487 VF 488
+
Sbjct: 449 TY 450
>gi|223890207 mouse double minute 2 homolog isoform MDM2i [Homo
sapiens]
Length = 295
Score = 150 bits (378), Expect = 3e-36
Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 32/275 (11%)
Query: 219 DLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEV 278
D T ++ A VS+ + D W +SVS+Q V +VE+ D+E S
Sbjct: 46 DTYTMKEDLDAGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLS------------ 92
Query: 279 GKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWY-SDCSKL 337
E+ + LSD+ D ED W+CT C + N P +C RCWALR++W D K
Sbjct: 93 ------EEGQELSDEDD-----EDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKD 141
Query: 338 THSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDL 397
+S + EG DVPDC++TI V +++ +++ + K+ S E D
Sbjct: 142 KGEISEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDY 198
Query: 398 AHSSESQETISSMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLCEKRPRDGNIIHGR 453
+ S S I S E + + T E++E N ++PC +C+ RP++G I+HG+
Sbjct: 199 SQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGK 258
Query: 454 TGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
TGHL+ CF CA++LKK CP+C++ IQ+++ +
Sbjct: 259 TGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTY 293
Score = 30.8 bits (68), Expect = 2.9
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 5/47 (10%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKE-----VMHYLGQYIMVKQLYDQ 68
VRPK LLK+L + GAQ + +T+KE V + G ++ + DQ
Sbjct: 28 VRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQ 74
>gi|89993693 mouse double minute 2 homolog isoform MDM2d [Homo
sapiens]
Length = 172
Score = 105 bits (262), Expect = 9e-23
Identities = 57/135 (42%), Positives = 87/135 (64%), Gaps = 2/135 (1%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 93
Query: 87 RQSFSVKDPSPLYDMLRKNLVTL-ATATTDAAQTLALAQDHSMDIPSQ-DQLKQSAEESS 144
SFSVK+ +Y M+ +NLV + ++D+ +++ + H Q D +++ EE
Sbjct: 94 VPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKP 153
Query: 145 TSRKRTTEDDIPTLP 159
++KR P +P
Sbjct: 154 KTKKRVWNLVCPLMP 168
>gi|89993690 mouse double minute 2 homolog isoform MDM2a [Homo
sapiens]
Length = 249
Score = 103 bits (258), Expect = 3e-22
Identities = 54/121 (44%), Positives = 79/121 (65%), Gaps = 1/121 (0%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 93
Query: 87 RQSFSVKDPSPLYDMLRKNLVTL-ATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESST 145
SFSVK+ +Y M+ +NLV + ++D+ +++ + H Q L Q +E
Sbjct: 94 VPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKP 153
Query: 146 S 146
S
Sbjct: 154 S 154
Score = 79.3 bits (194), Expect = 7e-15
Identities = 32/88 (36%), Positives = 56/88 (63%), Gaps = 2/88 (2%)
Query: 403 SQETISSMGEQLDNLSEQRTDTENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLVTC 460
S+ + SS + E + E++E N ++PC +C+ RP++G I+HG+TGHL+ C
Sbjct: 160 SRPSTSSRRRAISETEETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMAC 219
Query: 461 FHCARRLKKAGASCPICKKEIQLVIKVF 488
F CA++LKK CP+C++ IQ+++ +
Sbjct: 220 FTCAKKLKKRNKPCPVCRQPIQMIVLTY 247
>gi|89993691 mouse double minute 2 homolog isoform MDM2e [Homo
sapiens]
Length = 179
Score = 91.3 bits (225), Expect = 2e-18
Identities = 42/68 (61%), Positives = 55/68 (80%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLG 86
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC DLLG+L G
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFG 93
Query: 87 RQSFSVKD 94
SFSVK+
Sbjct: 94 VPSFSVKE 101
Score = 77.4 bits (189), Expect = 3e-14
Identities = 29/75 (38%), Positives = 52/75 (69%), Gaps = 6/75 (8%)
Query: 420 QRTDTENMEDCQ------NLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGAS 473
+R +T++ E+ N ++PC +C+ RP++G I+HG+TGHL+ CF CA++LKK
Sbjct: 103 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP 162
Query: 474 CPICKKEIQLVIKVF 488
CP+C++ IQ+++ +
Sbjct: 163 CPVCRQPIQMIVLTY 177
>gi|89993692 mouse double minute 2 homolog isoform MDM2b [Homo
sapiens]
Length = 111
Score = 73.2 bits (178), Expect = 5e-13
Identities = 32/53 (60%), Positives = 43/53 (81%)
Query: 27 VRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGD 79
VRPK LLK+L + GAQ + +T+KEV+ YLGQYIM K+LYD+++QH+VYC D
Sbjct: 34 VRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSND 86
>gi|223278368 neuralized-like [Homo sapiens]
Length = 574
Score = 41.6 bits (96), Expect = 0.002
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 3/53 (5%)
Query: 437 CSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKA-GASCPICKKEIQLVIKVF 488
C++C + D I GH+ C+ C RLKKA A CPIC++ I+ +IK +
Sbjct: 521 CTICYEHAVDTVIY--TCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTY 571
>gi|34452686 ring finger protein, LIM domain interacting [Homo
sapiens]
Length = 624
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 386 FDPCNSVEFLDLA-----HSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLC 440
FD S+ FL LA + + + EQ+DNL+ R+ EN + LK CS+C
Sbjct: 520 FDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLA-MRSFGEN-----DALKTCSVC 573
Query: 441 EKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEI 481
+GN + HC R ++CPIC++ +
Sbjct: 574 ITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAV 614
>gi|34452684 ring finger protein, LIM domain interacting [Homo
sapiens]
Length = 624
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 386 FDPCNSVEFLDLA-----HSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLC 440
FD S+ FL LA + + + EQ+DNL+ R+ EN + LK CS+C
Sbjct: 520 FDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLA-MRSFGEN-----DALKTCSVC 573
Query: 441 EKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEI 481
+GN + HC R ++CPIC++ +
Sbjct: 574 ITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAV 614
>gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/79 (31%), Positives = 38/79 (48%), Gaps = 20/79 (25%)
Query: 412 EQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAG 471
EQL L E+RT C +C ++ +I+ GHLV C CA L+K
Sbjct: 546 EQLRRLQEERT--------------CKVC--MDKEVSIVFIPCGHLVVCKDCAPSLRK-- 587
Query: 472 ASCPICKKEIQLVIKVFIA 490
CPIC+ I+ ++ F++
Sbjct: 588 --CPICRSTIKGTVRTFLS 604
>gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo
sapiens]
Length = 604
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/79 (31%), Positives = 38/79 (48%), Gaps = 20/79 (25%)
Query: 412 EQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAG 471
EQL L E+RT C +C ++ +I+ GHLV C CA L+K
Sbjct: 546 EQLRRLQEERT--------------CKVC--MDKEVSIVFIPCGHLVVCKDCAPSLRK-- 587
Query: 472 ASCPICKKEIQLVIKVFIA 490
CPIC+ I+ ++ F++
Sbjct: 588 --CPICRSTIKGTVRTFLS 604
>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
sapiens]
Length = 618
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 20/82 (24%)
Query: 409 SMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLK 468
S+ EQL L E+RT C +C ++ +++ GHLV C CA L+
Sbjct: 557 SLEEQLRRLQEERT--------------CKVC--MDKEVSVVFIPCGHLVVCQECAPSLR 600
Query: 469 KAGASCPICKKEIQLVIKVFIA 490
K CPIC+ I+ ++ F++
Sbjct: 601 K----CPICRGIIKGTVRTFLS 618
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 39.7 bits (91), Expect = 0.006
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 6/54 (11%)
Query: 434 LKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKV 487
L+ C +C RD + G GH+ TC C+ R+KK C ICK+++Q K+
Sbjct: 816 LEECMVCSDMKRD--TLFGPCGHIATCSLCSPRVKK----CLICKEQVQSRTKI 863
>gi|217416388 neuralized homolog 1B [Homo sapiens]
Length = 555
Score = 38.9 bits (89), Expect = 0.011
Identities = 17/35 (48%), Positives = 24/35 (68%), Gaps = 1/35 (2%)
Query: 455 GHLVTCFHCARRLKK-AGASCPICKKEIQLVIKVF 488
GH+ C C RLK+ A A CPIC++ I+ VIK++
Sbjct: 519 GHMCLCHSCGLRLKRQARACCPICRRPIKDVIKIY 553
>gi|37595539 ring finger protein 34 isoform 1 [Homo sapiens]
Length = 373
Score = 38.9 bits (89), Expect = 0.011
Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 18/87 (20%)
Query: 402 ESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCF 461
E++E S GE+L E+ D C + + C L E GH+VTC
Sbjct: 303 ENEENQKSYGERLQLQDEE--DDSLCRICMDAVIDCVLLE------------CGHMVTCT 348
Query: 462 HCARRLKKAGASCPICKKEIQLVIKVF 488
C +R+ + CPIC++ + + VF
Sbjct: 349 KCGKRM----SECPICRQYVVRAVHVF 371
>gi|37595537 ring finger protein 34 isoform 2 [Homo sapiens]
Length = 372
Score = 38.9 bits (89), Expect = 0.011
Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 18/87 (20%)
Query: 402 ESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCF 461
E++E S GE+L E+ D C + + C L E GH+VTC
Sbjct: 302 ENEENQKSYGERLQLQDEE--DDSLCRICMDAVIDCVLLE------------CGHMVTCT 347
Query: 462 HCARRLKKAGASCPICKKEIQLVIKVF 488
C +R+ + CPIC++ + + VF
Sbjct: 348 KCGKRM----SECPICRQYVVRAVHVF 370
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 37.7 bits (86), Expect = 0.024
Identities = 44/216 (20%), Positives = 77/216 (35%), Gaps = 12/216 (5%)
Query: 214 SNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDK 273
S+ S+D + D SD+++ N S S + S E SD
Sbjct: 835 SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894
Query: 274 KVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSD 333
+ D DS + SD +D +S+ NS SD
Sbjct: 895 SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNS-----------SD 943
Query: 334 CSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVE 393
S + S ++SD + + N +D D + S+ D+ ++S D +S
Sbjct: 944 SSDSSDSSNSSDSSNSSDSSN-SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Query: 394 FLDLAHSSESQETISSMGEQLDNLSEQRTDTENMED 429
D + SS+S ++ +S + S +D+ + D
Sbjct: 1003 SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSD 1038
>gi|62865649 rififylin [Homo sapiens]
Length = 363
Score = 37.4 bits (85), Expect = 0.031
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 6/52 (11%)
Query: 437 CSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
C +C P D ++ GH+VTC C +R+ + CPIC++ + + VF
Sbjct: 316 CKICMDSPIDCVLLE--CGHMVTCTKCGKRMNE----CPICRQYVIRAVHVF 361
>gi|17432433 rififylin [Homo sapiens]
Length = 363
Score = 37.4 bits (85), Expect = 0.031
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 6/52 (11%)
Query: 437 CSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
C +C P D ++ GH+VTC C +R+ + CPIC++ + + VF
Sbjct: 316 CKICMDSPIDCVLLE--CGHMVTCTKCGKRMNE----CPICRQYVIRAVHVF 361
>gi|4505721 peroxisomal biogenesis factor 12 [Homo sapiens]
Length = 359
Score = 36.6 bits (83), Expect = 0.053
Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 5/100 (5%)
Query: 392 VEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKP-CSLCEKRPRDGNII 450
++FLD +SSE+QETI S+ D + +K C LC K + ++
Sbjct: 258 LQFLDWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVL 317
Query: 451 HGRTGHLVTCFHCARRLKKAGASCPIC--KKEIQLVIKVF 488
T V C+ C ++ +CPI E+Q +IK++
Sbjct: 318 --ATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLY 355
>gi|214010238 mahogunin, ring finger 1 isoform 4 [Homo sapiens]
Length = 531
Score = 36.2 bits (82), Expect = 0.070
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 414 LDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGAS 473
++N + Q T + E+ N C +C RD I+ R HL C CA L+ +
Sbjct: 257 IENKNNQETKPSDDENSDNS-NECVVCLSDLRDTLILPCR--HLCLCTSCADTLRYQANN 313
Query: 474 CPICKKEIQLVIKV 487
CPIC+ + ++++
Sbjct: 314 CPICRLPFRALLQI 327
>gi|214010236 mahogunin, ring finger 1 isoform 3 [Homo sapiens]
Length = 552
Score = 36.2 bits (82), Expect = 0.070
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 414 LDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGAS 473
++N + Q T + E+ N C +C RD I+ R HL C CA L+ +
Sbjct: 256 IENKNNQETKPSDDENSDNS-NECVVCLSDLRDTLILPCR--HLCLCTSCADTLRYQANN 312
Query: 474 CPICKKEIQLVIKV 487
CPIC+ + ++++
Sbjct: 313 CPICRLPFRALLQI 326
>gi|214010234 mahogunin, ring finger 1 isoform 2 [Homo sapiens]
Length = 555
Score = 36.2 bits (82), Expect = 0.070
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 414 LDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGAS 473
++N + Q T + E+ N C +C RD I+ R HL C CA L+ +
Sbjct: 257 IENKNNQETKPSDDENSDNS-NECVVCLSDLRDTLILPCR--HLCLCTSCADTLRYQANN 313
Query: 474 CPICKKEIQLVIKV 487
CPIC+ + ++++
Sbjct: 314 CPICRLPFRALLQI 327
>gi|44917608 mahogunin, ring finger 1 isoform 1 [Homo sapiens]
Length = 576
Score = 36.2 bits (82), Expect = 0.070
Identities = 21/74 (28%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 414 LDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGAS 473
++N + Q T + E+ N C +C RD I+ R HL C CA L+ +
Sbjct: 256 IENKNNQETKPSDDENSDNS-NECVVCLSDLRDTLILPCR--HLCLCTSCADTLRYQANN 312
Query: 474 CPICKKEIQLVIKV 487
CPIC+ + ++++
Sbjct: 313 CPICRLPFRALLQI 326
>gi|171542821 mitochondrial ubiquitin ligase activator of NFKB 1
[Homo sapiens]
Length = 352
Score = 36.2 bits (82), Expect = 0.070
Identities = 26/105 (24%), Positives = 45/105 (42%), Gaps = 5/105 (4%)
Query: 386 FDPCNSVEFLDLAHSSESQETI--SSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKR 443
F C ++ F+ + QE + M E+ Q ED ++L C +C
Sbjct: 249 FATCATLFFILRKQYLQRQERLRLKQMQEEFQEHEAQLLSRAKPEDRESLKSACVVCLSS 308
Query: 444 PRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVF 488
+ + + GH+ +C C R L + CPIC++ I VI ++
Sbjct: 309 FK--SCVFLECGHVCSCTECYRALPEP-KKCPICRQAITRVIPLY 350
>gi|5174653 ring finger protein 6 [Homo sapiens]
Length = 685
Score = 34.7 bits (78), Expect = 0.20
Identities = 31/109 (28%), Positives = 48/109 (44%), Gaps = 13/109 (11%)
Query: 384 KLFDPCNSVE-----FLDLAH-----SSESQETISSMG-EQLDNLSEQRTDTENMEDCQN 432
+L +P N VE L LAH S+ + I + EQ+DNLS + + +++
Sbjct: 570 QLRNPNNLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDS--E 627
Query: 433 LLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEI 481
L K CS+C GN + HC R +CPIC++ +
Sbjct: 628 LGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPV 676
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,445,332
Number of Sequences: 37866
Number of extensions: 846595
Number of successful extensions: 2833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 2754
Number of HSP's gapped (non-prelim): 113
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.