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Search of human proteins with 87578396
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|87578396 microtubule-associated protein 2 isoform 1 [Homo
sapiens]
(1827 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|87578396 microtubule-associated protein 2 isoform 1 [Homo sap... 3593 0.0
gi|87578392 microtubule-associated protein 2 isoform 2 [Homo sap... 629 e-180
gi|87578255 microtubule-associated protein 2 isoform 4 [Homo sap... 613 e-175
gi|87578394 microtubule-associated protein 2 isoform 5 [Homo sap... 581 e-165
gi|8400715 microtubule-associated protein tau isoform 4 [Homo sa... 274 5e-73
gi|82534351 microtubule-associated protein tau isoform 1 [Homo s... 268 3e-71
gi|178557734 microtubule-associated protein tau isoform 6 [Homo ... 267 6e-71
gi|6754638 microtubule-associated protein tau isoform 2 [Homo sa... 261 4e-69
gi|8400711 microtubule-associated protein tau isoform 3 [Homo sa... 261 4e-69
gi|178557736 microtubule-associated protein tau isoform 5 [Homo ... 261 4e-69
gi|197276600 microtubule-associated protein 4 isoform 4 [Homo sa... 174 7e-43
gi|197276602 microtubule-associated protein 4 isoform 5 [Homo sa... 169 3e-41
gi|47519639 microtubule-associated protein 4 isoform 1 [Homo sap... 144 8e-34
gi|47519675 microtubule-associated protein 4 isoform 2 [Homo sap... 134 6e-31
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 75 8e-13
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 64 1e-09
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 64 1e-09
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 64 1e-09
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 64 1e-09
gi|150170670 piccolo isoform 2 [Homo sapiens] 62 4e-09
gi|150378539 piccolo isoform 1 [Homo sapiens] 62 4e-09
gi|87299628 biorientation of chromosomes in cell division 1-like... 62 7e-09
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 61 9e-09
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 61 9e-09
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 60 1e-08
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 60 1e-08
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 56 3e-07
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 55 6e-07
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 54 1e-06
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 52 4e-06
>gi|87578396 microtubule-associated protein 2 isoform 1 [Homo sapiens]
Length = 1827
Score = 3593 bits (9316), Expect = 0.0
Identities = 1827/1827 (100%), Positives = 1827/1827 (100%)
Query: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
Sbjct: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
Query: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
Sbjct: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
Query: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK 180
AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK
Sbjct: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK 180
Query: 181 ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQK 240
ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQK
Sbjct: 181 ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQK 240
Query: 241 TEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD 300
TEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD
Sbjct: 241 TEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD 300
Query: 301 IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPA 360
IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPA
Sbjct: 301 IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPA 360
Query: 361 TAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV 420
TAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV
Sbjct: 361 TAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV 420
Query: 421 QQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHT 480
QQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHT
Sbjct: 421 QQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHT 480
Query: 481 FSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMR 540
FSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMR
Sbjct: 481 FSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMR 540
Query: 541 VDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE 600
VDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE
Sbjct: 541 VDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE 600
Query: 601 SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMF 660
SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMF
Sbjct: 601 SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMF 660
Query: 661 TIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGR 720
TIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGR
Sbjct: 661 TIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGR 720
Query: 721 GHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEEST 780
GHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEEST
Sbjct: 721 GHDLSPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEEST 780
Query: 781 QAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVV 840
QAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVV
Sbjct: 781 QAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVV 840
Query: 841 EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT 900
EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT
Sbjct: 841 EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT 900
Query: 901 DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRL 960
DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRL
Sbjct: 901 DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRL 960
Query: 961 DTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLS 1020
DTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLS
Sbjct: 961 DTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLS 1020
Query: 1021 SVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP 1080
SVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP
Sbjct: 1021 SVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP 1080
Query: 1081 SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL 1140
SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL
Sbjct: 1081 SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL 1140
Query: 1141 TMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP 1200
TMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP
Sbjct: 1141 TMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP 1200
Query: 1201 KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDL 1260
KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDL
Sbjct: 1201 KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDL 1260
Query: 1261 GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVE 1320
GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVE
Sbjct: 1261 GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVE 1320
Query: 1321 RRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDD 1380
RRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDD
Sbjct: 1321 RRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDD 1380
Query: 1381 SIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST 1440
SIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST
Sbjct: 1381 SIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRIST 1440
Query: 1441 PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS 1500
PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS
Sbjct: 1441 PERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS 1500
Query: 1501 CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDE 1560
CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDE
Sbjct: 1501 CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDE 1560
Query: 1561 NSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTP 1620
NSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTP
Sbjct: 1561 NSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTP 1620
Query: 1621 SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGST 1680
SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGST
Sbjct: 1621 SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGST 1680
Query: 1681 DNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKV 1740
DNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKV
Sbjct: 1681 DNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKV 1740
Query: 1741 GSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS 1800
GSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS
Sbjct: 1741 GSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS 1800
Query: 1801 GSINLLESPQLATLAEDVTAALAKQGL 1827
GSINLLESPQLATLAEDVTAALAKQGL
Sbjct: 1801 GSINLLESPQLATLAEDVTAALAKQGL 1827
>gi|87578392 microtubule-associated protein 2 isoform 2 [Homo sapiens]
Length = 471
Score = 629 bits (1623), Expect = e-180
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1508 AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS 1567
AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS
Sbjct: 152 AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS 211
Query: 1568 SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH 1627
SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH
Sbjct: 212 SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH 271
Query: 1628 TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP 1687
TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP
Sbjct: 272 TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP 331
Query: 1688 KGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAH 1747
KGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAH
Sbjct: 332 KGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAH 391
Query: 1748 HVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLE 1807
HVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLE
Sbjct: 392 HVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLE 451
Query: 1808 SPQLATLAEDVTAALAKQGL 1827
SPQLATLAEDVTAALAKQGL
Sbjct: 452 SPQLATLAEDVTAALAKQGL 471
Score = 307 bits (786), Expect = 7e-83
Identities = 165/221 (74%), Positives = 179/221 (80%), Gaps = 15/221 (6%)
Query: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
Sbjct: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
Query: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
Sbjct: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
Query: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK 180
AALPLAAEETANLPPSPPPSPASEQTVTVEE + L PS + + K+K
Sbjct: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEE--------AAGGESALAPSVFKQA--KDK 170
Query: 181 ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKA 221
S+ +K E K ++L P + P ++ + G +E +
Sbjct: 171 VSDGVTKSPE--KRSSL---PRPSSILPPRRGVSGDRDENS 206
>gi|87578255 microtubule-associated protein 2 isoform 4 [Homo sapiens]
Length = 502
Score = 613 bits (1581), Expect = e-175
Identities = 320/351 (91%), Positives = 320/351 (91%), Gaps = 31/351 (8%)
Query: 1508 AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS 1567
AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS
Sbjct: 152 AAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNS 211
Query: 1568 SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH 1627
SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH
Sbjct: 212 SISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPH 271
Query: 1628 TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP 1687
TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP
Sbjct: 272 TPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQP 331
Query: 1688 KGGQV-------------------------------QIVTKKIDLSHVTSKCGSLKNIRH 1716
KGGQV QIVTKKIDLSHVTSKCGSLKNIRH
Sbjct: 332 KGGQVRILNKKIDFSKVQSRCGSKDNIKHSAGGGNVQIVTKKIDLSHVTSKCGSLKNIRH 391
Query: 1717 RPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGA 1776
RPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGA
Sbjct: 392 RPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGA 451
Query: 1777 EIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
EIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL
Sbjct: 452 EIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 502
Score = 307 bits (786), Expect = 7e-83
Identities = 165/221 (74%), Positives = 179/221 (80%), Gaps = 15/221 (6%)
Query: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
Sbjct: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
Query: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
Sbjct: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
Query: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK 180
AALPLAAEETANLPPSPPPSPASEQTVTVEE + L PS + + K+K
Sbjct: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEE--------AAGGESALAPSVFKQA--KDK 170
Query: 181 ESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKA 221
S+ +K E K ++L P + P ++ + G +E +
Sbjct: 171 VSDGVTKSPE--KRSSL---PRPSSILPPRRGVSGDRDENS 206
>gi|87578394 microtubule-associated protein 2 isoform 5 [Homo sapiens]
Length = 559
Score = 581 bits (1497), Expect = e-165
Identities = 347/556 (62%), Positives = 381/556 (68%), Gaps = 59/556 (10%)
Query: 1317 PEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTE-TYDDYKDE 1375
P E H E + A E +G P E EE A E+ ++ TY + K E
Sbjct: 18 PLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYR----EDEEGAFGEHGSQGTYSNTK-E 72
Query: 1376 TTIDDSIMDADSLWVDTQDDDRS----IMTEQLETIPKEEKAEKEARRSSLEKHRKEKPF 1431
I+ + AD +T ++ + ++T + + K E+ EKEA+
Sbjct: 73 NGINGELTSADR---ETAEEVSARIVQVVTAEAVAVLKGEQ-EKEAQHKDQTAALPLAAE 128
Query: 1432 KTGRGRISTP-----ERKVAKKEP----STVSRDEVRRKKAVYKKAELAKKTEVQAHSPS 1482
+T S P E+ V +E S ++ ++ K + L+K +Q + S
Sbjct: 129 ETANLPPSPPPSPASEQTVTVEEAAGGESALAPSVFKQAKDKVSNSTLSKIPALQGSTKS 188
Query: 1483 RKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLP 1542
++ R T + + T+AG L S K DGVTKSPEKRSSLP
Sbjct: 189 PRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYS-----KSGNKDGVTKSPEKRSSLP 243
Query: 1543 RPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAIT 1602
RPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAIT
Sbjct: 244 RPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAIT 303
Query: 1603 PGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRL 1662
PGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRL
Sbjct: 304 PGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRL 363
Query: 1663 INQPLPDLKNVKSKIGSTDNIKYQPKGGQV------------------------------ 1692
INQPLPDLKNVKSKIGSTDNIKYQPKGGQV
Sbjct: 364 INQPLPDLKNVKSKIGSTDNIKYQPKGGQVRILNKKIDFSKVQSRCGSKDNIKHSAGGGN 423
Query: 1693 -QIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPG 1751
QIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPG
Sbjct: 424 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPG 483
Query: 1752 GGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQL 1811
GGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQL
Sbjct: 484 GGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQL 543
Query: 1812 ATLAEDVTAALAKQGL 1827
ATLAEDVTAALAKQGL
Sbjct: 544 ATLAEDVTAALAKQGL 559
Score = 305 bits (782), Expect = 2e-82
Identities = 173/258 (67%), Positives = 186/258 (72%), Gaps = 18/258 (6%)
Query: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE
Sbjct: 1 MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGE 60
Query: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT
Sbjct: 61 HGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQT 120
Query: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEK 180
AALPLAAEETANLPPSPPPSPASEQTVTVEE + L PS + + K
Sbjct: 121 AALPLAAEETANLPPSPPPSPASEQTVTVEE--------AAGGESALAPSVFKQAKDKVS 172
Query: 181 ESEKQSKP---GEDLKHAALVSQPETTK--TYPDKKDMQGT---EEEKAPLALFGHT--L 230
S P G + P TTK T+ D +Q T ++ P + G+ +
Sbjct: 173 NSTLSKIPALQGSTKSPRYSSACPSTTKRATFSDSLLIQPTSAGSTDRLPYSKSGNKDGV 232
Query: 231 VASLEDMKQKTEPSLVVP 248
S E PS ++P
Sbjct: 233 TKSPEKRSSLPRPSSILP 250
>gi|8400715 microtubule-associated protein tau isoform 4 [Homo
sapiens]
Length = 352
Score = 274 bits (701), Expect = 5e-73
Identities = 149/257 (57%), Positives = 188/257 (73%), Gaps = 22/257 (8%)
Query: 1586 GKSGTSTPTT-PGSTAITPGTPPS------------YSSRTPGTPGTP-SYPRTPHTPGT 1631
G+ G + T P T P TPPS YSS PG+PGTP S RTP P
Sbjct: 103 GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSS--PGSPGTPGSRSRTPSLPTP 160
Query: 1632 PKSAILVPSEKKVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGSTDNIKYQPKGG 1690
P KKVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGST+N+K+QP GG
Sbjct: 161 PTR-----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG 215
Query: 1691 QVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVP 1750
+VQIV K +DLS VTSKCGSL NI H+PGGG+V+++S KLDFK++ Q+K+GSLDN HVP
Sbjct: 216 KVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVP 275
Query: 1751 GGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQ 1810
GGGN KI++ KL FRE+AKA+ DHGAEI+ +SP S SPR LSNVSS+GSI++++SPQ
Sbjct: 276 GGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQ 335
Query: 1811 LATLAEDVTAALAKQGL 1827
LATLA++V+A+LAKQGL
Sbjct: 336 LATLADEVSASLAKQGL 352
>gi|82534351 microtubule-associated protein tau isoform 1 [Homo
sapiens]
Length = 758
Score = 268 bits (686), Expect = 3e-71
Identities = 208/577 (36%), Positives = 286/577 (49%), Gaps = 96/577 (16%)
Query: 1320 ERRPSPHDE--EEFEVEEAAEAQAEPKDGSP----EAPASPEREEVALSEYKTETYDDY- 1372
+ RP +E E+ +V+E++ + P SP P + RE ++ + E
Sbjct: 209 KERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLP 268
Query: 1373 -----KDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEK----AEKEARRSSLE 1423
K T I S D S+ D T +E P +K +E+ R++
Sbjct: 269 VDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFP 328
Query: 1424 KHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYK----KAELAKKTEVQAH 1479
E P G + ++ EPS R K V + KA + K++
Sbjct: 329 GAPGEGPEARGPS-LGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTG 387
Query: 1480 SPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALA-PSVFKQAKDKVSDGVTKSPEKR 1538
S +K + C+ K G L PS S V P
Sbjct: 388 SDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPS---------SPAVCPEPP-- 436
Query: 1539 SSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRA--GKSGTSTPTT- 1595
S P+ S + R G SG ++ + + +T + P A G+ G + T
Sbjct: 437 -SSPKHVSSVTSRTGSSGAKE-------MKLKGADGKTKIATPRGAAPPGQKGQANATRI 488
Query: 1596 PGSTAITPGTPPS------------YSSRTPGTPGTP-SYPRTPHTPGTPKSAILVPSEK 1642
P T P TPPS YSS PG+PGTP S RTP P P K
Sbjct: 489 PAKTPPAPKTPPSSGEPPKSGDRSGYSS--PGSPGTPGSRSRTPSLPTPPTR-----EPK 541
Query: 1643 KVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDL 1701
KVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGST+N+K+QP GG+VQI+ KK+DL
Sbjct: 542 KVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDL 601
Query: 1702 SHV-------------------------------TSKCGSLKNIRHRPGGGRVKIESVKL 1730
S+V TSKCGSL NI H+PGGG+V+++S KL
Sbjct: 602 SNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKL 661
Query: 1731 DFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVAS 1790
DFK++ Q+K+GSLDN HVPGGGN KI++ KL FRE+AKA+ DHGAEI+ +SP S S
Sbjct: 662 DFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTS 721
Query: 1791 PRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
PR LSNVSS+GSI++++SPQLATLA++V+A+LAKQGL
Sbjct: 722 PRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 758
>gi|178557734 microtubule-associated protein tau isoform 6 [Homo
sapiens]
Length = 776
Score = 267 bits (683), Expect = 6e-71
Identities = 204/599 (34%), Positives = 289/599 (48%), Gaps = 122/599 (20%)
Query: 1320 ERRPSPHDE--EEFEVEEAAEAQAEPKDGSP----EAPASPEREEVALSEYKTETYDDY- 1372
+ RP +E E+ +V+E++ + P SP P + RE ++ + E
Sbjct: 209 KERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLP 268
Query: 1373 -----KDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEK------------ 1415
K T I S D S+ D T +E P +K +
Sbjct: 269 VDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFP 328
Query: 1416 -------EARRSSLEKHRKE---------KPFKTGRG----RISTPERKVAKKEPSTVSR 1455
EAR SL + KE +P RG R+ + ++ K
Sbjct: 329 GAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGS 388
Query: 1456 DEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPT----------HLSCVKRK 1505
D+ + K + A+ K + P I+ + P H+S V +
Sbjct: 389 DDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKHVSSVTSR 448
Query: 1506 TTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSL 1565
T ++G K+ K K +DG TK + P PP G G +
Sbjct: 449 TGSSGA---------KEMKLKGADGKTK-------IATPRGAAPP--GQKGQANATRIPA 490
Query: 1566 NSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRT----PGTPGTP- 1620
+ + ++ ++ ++R P P S G PP R+ PG+PGTP
Sbjct: 491 KTPPAPKTPPSSATKQVQRR-----PPPAGPRSER---GEPPKSGDRSGYSSPGSPGTPG 542
Query: 1621 SYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGS 1679
S RTP P P KKVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGS
Sbjct: 543 SRSRTPSLPTPPTR-----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGS 597
Query: 1680 TDNIKYQPKGGQVQIVTKKIDLSHV-------------------------------TSKC 1708
T+N+K+QP GG+VQI+ KK+DLS+V TSKC
Sbjct: 598 TENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKC 657
Query: 1709 GSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHA 1768
GSL NI H+PGGG+V+++S KLDFK++ Q+K+GSLDN HVPGGGN KI++ KL FRE+A
Sbjct: 658 GSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENA 717
Query: 1769 KARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
KA+ DHGAEI+ +SP S SPR LSNVSS+GSI++++SPQLATLA++V+A+LAKQGL
Sbjct: 718 KAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 776
>gi|6754638 microtubule-associated protein tau isoform 2 [Homo
sapiens]
Length = 441
Score = 261 bits (667), Expect = 4e-69
Identities = 149/288 (51%), Positives = 190/288 (65%), Gaps = 53/288 (18%)
Query: 1586 GKSGTSTPTT-PGSTAITPGTPPS------------YSSRTPGTPGTP-SYPRTPHTPGT 1631
G+ G + T P T P TPPS YSS PG+PGTP S RTP P
Sbjct: 161 GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSS--PGSPGTPGSRSRTPSLPTP 218
Query: 1632 PKSAILVPSEKKVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGSTDNIKYQPKGG 1690
P KKVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGST+N+K+QP GG
Sbjct: 219 PTR-----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG 273
Query: 1691 QVQIVTKKIDLSHV-------------------------------TSKCGSLKNIRHRPG 1719
+VQI+ KK+DLS+V TSKCGSL NI H+PG
Sbjct: 274 KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPG 333
Query: 1720 GGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEII 1779
GG+V+++S KLDFK++ Q+K+GSLDN HVPGGGN KI++ KL FRE+AKA+ DHGAEI+
Sbjct: 334 GGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIV 393
Query: 1780 TQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
+SP S SPR LSNVSS+GSI++++SPQLATLA++V+A+LAKQGL
Sbjct: 394 YKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 441
>gi|8400711 microtubule-associated protein tau isoform 3 [Homo
sapiens]
Length = 383
Score = 261 bits (667), Expect = 4e-69
Identities = 149/288 (51%), Positives = 190/288 (65%), Gaps = 53/288 (18%)
Query: 1586 GKSGTSTPTT-PGSTAITPGTPPS------------YSSRTPGTPGTP-SYPRTPHTPGT 1631
G+ G + T P T P TPPS YSS PG+PGTP S RTP P
Sbjct: 103 GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSS--PGSPGTPGSRSRTPSLPTP 160
Query: 1632 PKSAILVPSEKKVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGSTDNIKYQPKGG 1690
P KKVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGST+N+K+QP GG
Sbjct: 161 PTR-----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG 215
Query: 1691 QVQIVTKKIDLSHV-------------------------------TSKCGSLKNIRHRPG 1719
+VQI+ KK+DLS+V TSKCGSL NI H+PG
Sbjct: 216 KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPG 275
Query: 1720 GGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEII 1779
GG+V+++S KLDFK++ Q+K+GSLDN HVPGGGN KI++ KL FRE+AKA+ DHGAEI+
Sbjct: 276 GGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIV 335
Query: 1780 TQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
+SP S SPR LSNVSS+GSI++++SPQLATLA++V+A+LAKQGL
Sbjct: 336 YKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 383
>gi|178557736 microtubule-associated protein tau isoform 5 [Homo
sapiens]
Length = 412
Score = 261 bits (667), Expect = 4e-69
Identities = 149/288 (51%), Positives = 190/288 (65%), Gaps = 53/288 (18%)
Query: 1586 GKSGTSTPTT-PGSTAITPGTPPS------------YSSRTPGTPGTP-SYPRTPHTPGT 1631
G+ G + T P T P TPPS YSS PG+PGTP S RTP P
Sbjct: 132 GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSS--PGSPGTPGSRSRTPSLPTP 189
Query: 1632 PKSAILVPSEKKVAIIRTPPKSPATPK-QLRLINQPLPDLKNVKSKIGSTDNIKYQPKGG 1690
P KKVA++RTPPKSP++ K +L+ P+PDLKNVKSKIGST+N+K+QP GG
Sbjct: 190 PTR-----EPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGG 244
Query: 1691 QVQIVTKKIDLSHV-------------------------------TSKCGSLKNIRHRPG 1719
+VQI+ KK+DLS+V TSKCGSL NI H+PG
Sbjct: 245 KVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPG 304
Query: 1720 GGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEII 1779
GG+V+++S KLDFK++ Q+K+GSLDN HVPGGGN KI++ KL FRE+AKA+ DHGAEI+
Sbjct: 305 GGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIV 364
Query: 1780 TQSPGRSSVASPRRLSNVSSSGSINLLESPQLATLAEDVTAALAKQGL 1827
+SP S SPR LSNVSS+GSI++++SPQLATLA++V+A+LAKQGL
Sbjct: 365 YKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL 412
>gi|197276600 microtubule-associated protein 4 isoform 4 [Homo
sapiens]
Length = 1135
Score = 174 bits (441), Expect = 7e-43
Identities = 215/849 (25%), Positives = 348/849 (40%), Gaps = 95/849 (11%)
Query: 997 EQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQM 1056
+ AL KD+ +PT+ E A P +V +K V + V DV + +
Sbjct: 299 DMALVKDMELPTE--KEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETER 356
Query: 1057 ASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAK 1116
AS + +D + ++ +P + D + G KE V K+ V
Sbjct: 357 ASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVP---AKDLVLL 413
Query: 1117 PDLVHQEAVDKEESYE-SSGEHESLTMESLKADEGKKETSPESSLI---------QDEIA 1166
++ +A D S E SS E +L+ E+ A PE+++I + E+A
Sbjct: 414 SEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVA 473
Query: 1167 -VKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETI 1225
VK ++P D+A +V + P E++ +TP E +
Sbjct: 474 PVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKN 533
Query: 1226 VSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGARE----EFVETCP------- 1274
V P E++ E + + D + V+ A++ E P
Sbjct: 534 VCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDME 593
Query: 1275 --SEHKGVIES--VVTIED-------DFITVVQTTTDEGESGSHSVRFAALEQPEVERRP 1323
KG+ E + +++D F+ +T T G+ S ++ + ER+P
Sbjct: 594 IAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKP 653
Query: 1324 SPHDEEEFEVEEAAEAQAEPKDGSP---------------EAPASPEREEVALSEY---K 1365
E E + A+ P++G P E P SPE++ L+ K
Sbjct: 654 CNSQPSELSSETSGIAR--PEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAK 711
Query: 1366 TETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSL-EK 1424
T T T++ A + S+ + + P + A AR S L K
Sbjct: 712 TSTSKAKTQPTSLPKQ--PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSK 769
Query: 1425 HRKEKPFKTGRGRISTPERKVAKKEPSTV--SRDEVRRKKAVYKKAELAK--KTEVQAHS 1480
K KP + PE++ + +P++ SR + + V K A T + S
Sbjct: 770 DVKPKPIADAKA----PEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRS 825
Query: 1481 PSRKFILKPAIKYT--RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKS---- 1534
PS KP T +P + + K+ A + S K G +
Sbjct: 826 PSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVV 885
Query: 1535 PEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPT 1594
P + + P PS P D+ S +S+ +R T + + + +
Sbjct: 886 PSRVKATPMPSR---PSTTPFIDKKPTSAKPSSTTPRLSRLATNT-----SAPDLKNVRS 937
Query: 1595 TPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSP 1654
GST P ++ + R P + K+A + S +K P
Sbjct: 938 KVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK---------QP 988
Query: 1655 ATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNI 1714
A +++++++ + +++SK GS DNIK+ P GG VQI KK+D+S V+SKCGS NI
Sbjct: 989 AG--KVQIVSKKV-SYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANI 1045
Query: 1715 RHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDH 1774
+H+PGGG VKIES KL+FKEKAQAKVGSLDN H+P GG VKI++ +L FR +A+AR DH
Sbjct: 1046 KHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKIETYRLTFRANARARTDH 1105
Query: 1775 GAEIITQSP 1783
GA+I+++ P
Sbjct: 1106 GADIVSRPP 1114
>gi|197276602 microtubule-associated protein 4 isoform 5 [Homo
sapiens]
Length = 817
Score = 169 bits (427), Expect = 3e-41
Identities = 129/375 (34%), Positives = 187/375 (49%), Gaps = 34/375 (9%)
Query: 1409 KEEKAEKEARRSSLEKHRKEKPFKTGRGR-ISTPERKVAKKEP-------STVSRDEVRR 1460
+E++ K+ + + + + + +P +G G I+TP K P +T +
Sbjct: 390 QEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTST 449
Query: 1461 KKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVF 1520
KA + L K+ K KP + + KR A+ S L PS
Sbjct: 450 SKAKTQPTSLPKQPAPTTIGGLNK---KPMSLASGLVPAAPPKRPAVASARPSIL-PS-- 503
Query: 1521 KQAKDK-VSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRS 1579
K K K ++D K+PEKR+S +P+S R G + + ++++S+ +
Sbjct: 504 KDVKPKPIADA--KAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP 561
Query: 1580 EPIRRAGKSGTSTPTTPGSTA-ITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILV 1638
+ + T P +T + P+ SR P + T S +T GT +A +V
Sbjct: 562 STLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSR-PKSTSTSSMKKTTTLSGTAPAAGVV 620
Query: 1639 PSEKKVAIIRTPPK--------------SPATPKQLRLI-NQPLPDLKNVKSKIGSTDNI 1683
PS K + + P S TP+ RL N PDLKNV+SK+GST+NI
Sbjct: 621 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENI 680
Query: 1684 KYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSL 1743
K+QP GG+VQI KK+D+S V+SKCGS NI+H+PGGG VKIES KL+FKEKAQAKVGSL
Sbjct: 681 KHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSL 740
Query: 1744 DNAHHVPGGGNVKID 1758
DN H+P GG VK +
Sbjct: 741 DNVGHLPAGGAVKTE 755
>gi|47519639 microtubule-associated protein 4 isoform 1 [Homo sapiens]
Length = 1152
Score = 144 bits (363), Expect = 8e-34
Identities = 202/824 (24%), Positives = 327/824 (39%), Gaps = 95/824 (11%)
Query: 997 EQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQM 1056
+ AL KD+ +PT+ E A P +V +K V + V DV + +
Sbjct: 299 DMALVKDMELPTE--KEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETER 356
Query: 1057 ASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAK 1116
AS + +D + ++ +P + D + G KE V K+ V
Sbjct: 357 ASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVP---AKDLVLL 413
Query: 1117 PDLVHQEAVDKEESYE-SSGEHESLTMESLKADEGKKETSPESSLI---------QDEIA 1166
++ +A D S E SS E +L+ E+ A PE+++I + E+A
Sbjct: 414 SEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVA 473
Query: 1167 -VKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETI 1225
VK ++P D+A +V + P E++ +TP E +
Sbjct: 474 PVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKN 533
Query: 1226 VSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGARE----EFVETCP------- 1274
V P E++ E + + D + V+ A++ E P
Sbjct: 534 VCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDME 593
Query: 1275 --SEHKGVIES--VVTIED-------DFITVVQTTTDEGESGSHSVRFAALEQPEVERRP 1323
KG+ E + +++D F+ +T T G+ S ++ + ER+P
Sbjct: 594 IAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKP 653
Query: 1324 SPHDEEEFEVEEAAEAQAEPKDGSP---------------EAPASPEREEVALSEY---K 1365
E E + A+ P++G P E P SPE++ L+ K
Sbjct: 654 CNSQPSELSSETSGIAR--PEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAK 711
Query: 1366 TETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSL-EK 1424
T T T++ A + S+ + + P + A AR S L K
Sbjct: 712 TSTSKAKTQPTSLPKQ--PAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSK 769
Query: 1425 HRKEKPFKTGRGRISTPERKVAKKEPSTV--SRDEVRRKKAVYKKAELAK--KTEVQAHS 1480
K KP + PE++ + +P++ SR + + V K A T + S
Sbjct: 770 DVKPKPIADAKA----PEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRS 825
Query: 1481 PSRKFILKPAIKYT--RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKS---- 1534
PS KP T +P + + K+ A + S K G +
Sbjct: 826 PSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVV 885
Query: 1535 PEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPT 1594
P + + P PS P D+ S +S+ +R T + + + +
Sbjct: 886 PSRVKATPMPSR---PSTTPFIDKKPTSAKPSSTTPRLSRLATNT-----SAPDLKNVRS 937
Query: 1595 TPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSP 1654
GST P ++ + R P + K+A + S +K P
Sbjct: 938 KVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK---------QP 988
Query: 1655 ATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNI 1714
A +++++++ + +++SK GS DNIK+ P GG VQI KK+D+S V+SKCGS NI
Sbjct: 989 AG--KVQIVSKKV-SYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANI 1045
Query: 1715 RHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKID 1758
+H+PGGG VKIES KL+FKEKAQAKVGSLDN H+P GG VK +
Sbjct: 1046 KHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTE 1089
>gi|47519675 microtubule-associated protein 4 isoform 2 [Homo sapiens]
Length = 887
Score = 134 bits (338), Expect = 6e-31
Identities = 190/772 (24%), Positives = 305/772 (39%), Gaps = 108/772 (13%)
Query: 1018 GLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQD 1077
G S+ AE+ S K E G+D +G + + AS +++ + TEL
Sbjct: 130 GDHSLKNKAELADSMKNEAGID---EGHVIGESESVHSGASKHSVE--KVTELAKGHLLP 184
Query: 1078 MTP--SSKAPQEADAFMG-VESGHMKEGTKVSETEVKE---KVAKPDLVH---------- 1121
P P EA A G + G+ E E KE V PDL+
Sbjct: 185 GVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCE 244
Query: 1122 -QEAVDKE-ESYESSGEHESLTMESLKADEGK-KETSPESSLIQDEIAVKLSVEIPCPPA 1178
Q A D+ + +S + LT+ S K++ K KE S + + E SV +P P
Sbjct: 245 DQNAQDRNSKGSDSLNKKVDLTLLSPKSENDKLKEISLACKITELE-----SVSLPTP-- 297
Query: 1179 VSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEE 1238
+ ++D ++ P E +T I V P + + E + +E+ E
Sbjct: 298 --------EIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSE 349
Query: 1239 IEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTT 1298
+ GE K D ++ + R P++ +G+ ++ +
Sbjct: 350 SKTPGEGKK----EDKSRMAEPMKGYMR-------PTKSRGLTP-----------LLPKS 387
Query: 1299 TDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEP-KDGSPEAPASPERE 1357
T + + ++ A + +PE R + E P K P A P +
Sbjct: 388 TIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKT 447
Query: 1358 EVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEA 1417
+ ++ + + TTI S+ + + P + A A
Sbjct: 448 STSKAKTQPTSLPKQPAPTTIGG-----------LNKKPMSLASGLVPAAPPKRPAVASA 496
Query: 1418 RRSSL-EKHRKEKPFKTGRGRISTPERKVAKKEPSTV--SRDEVRRKKAVYKKAELAK-- 1472
R S L K K KP + PE++ + +P++ SR + + V K A
Sbjct: 497 RPSILPSKDVKPKPIADAKA----PEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVA 552
Query: 1473 KTEVQAHSPSRKFILKPAIKYT--RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDG 1530
T + SPS KP T +P + + K+ A + S K G
Sbjct: 553 STGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSG 612
Query: 1531 VTKS----PEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAG 1586
+ P + + P PS P D+ S +S+ +R T + +
Sbjct: 613 TAPAAGVVPSRVKATPMPSR---PSTTPFIDKKPTSAKPSSTTPRLSRLATNT-----SA 664
Query: 1587 KSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAI 1646
+ + GST P ++ + R P + K+A + S +K
Sbjct: 665 PDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK--- 721
Query: 1647 IRTPPKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTS 1706
PA +++++++ + +++SK GS DNIK+ P GG VQI KK+D+S V+S
Sbjct: 722 ------QPAG--KVQIVSKKV-SYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSS 772
Query: 1707 KCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKID 1758
KCGS NI+H+PGGG VKIES KL+FKEKAQAKVGSLDN H+P GG VK +
Sbjct: 773 KCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTE 824
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 74.7 bits (182), Expect = 8e-13
Identities = 137/603 (22%), Positives = 224/603 (37%), Gaps = 87/603 (14%)
Query: 85 ETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASE 144
E EE ++ + VT E K E+ KE + ++ A EET + P SP E
Sbjct: 459 EQTEET--QVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG-GEEETKSPPAEEAASPEKE 515
Query: 145 QTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQ---------SKPGEDLKHA 195
V+E+ + ++ + +++E S +K K K+ S E+ K
Sbjct: 516 AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP 575
Query: 196 ALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKE 255
A V PE K+ P K++ + E K+P + S V P E
Sbjct: 576 AEVKSPEKAKS-PAKEEAKSPAEAKSP-----------------EKAKSPVKEEAKSPAE 617
Query: 256 PPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPS 315
+P +++ + P E K E +P +P + K P+ E + S
Sbjct: 618 AKSPVKEE---AKSPAEVKSPE-KAKSPTKEEAKSPEKAKS-----PEKEEAKSPEKAKS 668
Query: 316 PFQGGSFT-----LPLDVMKNEIVTETSPFAPAFLQPDDKKS--LQQTSGPATAKDSFKI 368
P + + + P+ SP P+ KS ++ P AK K
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 369 E--EPHEAKPDKMAEA-------PPSEAMTL---PKDAHIPVVEE--HVMGKVLEEEKEA 414
E P +AK EA P +A TL +A P EE K E+ K
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788
Query: 415 INQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESK---PPKPADEEIG 471
+ +E +P ++ EKE K E K+ + ++E P+E K PPK A+EE
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK-PQEVKVKEPPKKAEEEKA 847
Query: 472 IIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKS 531
TE E+KD + E+A A K EK EP+ K
Sbjct: 848 PATPKTE----EKKDSKK--------------EEAPKKEAPKPKVEEK--KEPAVEKPKE 887
Query: 532 SIQELFEMRVDDKDKIEGVGAATSAELDM---PFYEDKSGMSKYFETSALKEEATKSIEP 588
S E + +DK K+ A++++ ++K+ ++K A +E +K E
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947
Query: 589 GSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDL 648
E DT+E + + ++ +T + P A++A S+ S
Sbjct: 948 KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007
Query: 649 PEE 651
PE+
Sbjct: 1008 PEK 1010
Score = 74.7 bits (182), Expect = 8e-13
Identities = 125/552 (22%), Positives = 221/552 (40%), Gaps = 75/552 (13%)
Query: 6 KDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQG 65
K+EAK+P +P E + P E+K A A P + E + ++
Sbjct: 521 KEEAKSPAEAKSPEKEEA--KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV 578
Query: 66 TYSNTKENGINGELTS-ADRETAEEVSARIVQVVT--AEAVAVLKGEQEKEAQHKDQTAA 122
++ E S A+ ++ E+ + + + AEA + +K E + A+ K A
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 123 LPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKES 182
EE + P SP E+ + E+ +K + + P + K
Sbjct: 639 KSPTKEEAKS--PEKAKSPEKEEAKSPEK-----AKSPVKAEAKSPEKAKSPVKAEAKSP 691
Query: 183 EKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTE 242
EK P +K A PE K+ P K++ + E+ K+P+ T + +K++ +
Sbjct: 692 EKAKSP---VKEEA--KSPEKAKS-PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAK 745
Query: 243 PSLVVPGIDLPKEPPTPKEQKDWFIEMP---TEAKKDEWGLVAPISPGPLTPMREKDVFD 299
P++ +P++ K ++ P T AK++ SP P + K
Sbjct: 746 S---------PEKAKSPEKAKTLDVKSPEAKTPAKEEAR------SPADKFPEKAKSPVK 790
Query: 300 DIPKWEGKQFDSPMPSPFQGGSFTLPL-DVMKNEIVTETSPFAPAFLQPDDKKSLQQTSG 358
+ K K SP+ + +P + +K+ + E P +P K ++
Sbjct: 791 EEVKSPEKA-KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP--KKAEEEKA 847
Query: 359 PATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEH---VMGKVLEEEKEAI 415
PAT K E K K EAP EA PK P VEE + K E + EA
Sbjct: 848 PATPKTE-------EKKDSKKEEAPKKEA---PK----PKVEEKKEPAVEKPKESKVEAK 893
Query: 416 NQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESK-PPKPAD-EEIGII 473
+E ++ TP + P E + + K +EKT ++ KE ++K P KPA+ +E
Sbjct: 894 KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953
Query: 474 QTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSA-LIEKSS 532
+ T+ +++ +++P T+ ++ KTL K ++P A EKSS
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKED---------------DKTLSKEPSKPKAEKAEKSS 998
Query: 533 IQELFEMRVDDK 544
+ + + +K
Sbjct: 999 STDQKDSKPPEK 1010
Score = 65.5 bits (158), Expect = 5e-10
Identities = 125/553 (22%), Positives = 214/553 (38%), Gaps = 52/553 (9%)
Query: 132 NLPPSPP--PSPASEQTVTVEEDLLTASKME-----FHDQQELTPSTAEPSDQKEKES-E 183
+LP P PS ++ V EE + K E +Q E T T E ++++EKE+ E
Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
Query: 184 KQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEP 243
++ K E + E TK+ P ++ +E K+P+ + + K++ +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 244 SLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPL-TPMREKDVFDDIP 302
V + K P KE+ + P EAK E SP + +P + K P
Sbjct: 541 PAEVKSPEKAKSP--AKEE----AKSPPEAKSPE--KEEAKSPAEVKSPEKAKS-----P 587
Query: 303 KWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGP--- 359
E + + SP + S P+ SP P + KS ++ P
Sbjct: 588 AKEEAKSPAEAKSPEKAKS---PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 360 -ATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQE 418
A + + K E EAK + A++P P+ A PV E K E+ K + +E
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE---AKSPEKAKSPVKEE 701
Query: 419 TVQQRDTFTPSGQEPILTEK-ETELKLEEKTTISDKEAVPKESKPPKPA--DEEIGIIQT 475
+P +E EK ++ +K E KT K V +E+K P+ A E+ +
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 476 STEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKS-SIQ 534
+ + K++ + D FP + V + + + + + E + EK +
Sbjct: 762 KSPEAKTPAKEEARS----PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 535 ELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFE--TSALKEEATKSIEPGSDY 592
E + V +++K + V E E+K+ + E + KEEA K P
Sbjct: 818 EEVKSPVKEEEKPQEVKV---KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
Query: 593 YELSDTR-ESVHESIDTMSPMHKNGDKEFQTGKESQPS-----PPAQEAGYSTLAQSYPS 646
E + E ES K+ T ++ P+ A+ + +A+ P
Sbjct: 875 EEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 647 DL-PEEPSSPQER 658
D +EPS P E+
Sbjct: 935 DAKAKEPSKPAEK 947
Score = 65.1 bits (157), Expect = 6e-10
Identities = 114/536 (21%), Positives = 208/536 (38%), Gaps = 34/536 (6%)
Query: 968 EEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIP-TDASSEKAEKGLSSVPEIA 1026
EE ++KE K EE G+E E G + A++ + P +A S E+ S A
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSP----A 528
Query: 1027 EVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQ 1086
E + +K E V+ K + S E K A +K+P
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588
Query: 1087 EADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEA-----VDKEESYESSGEHESLT 1141
+ +A E+ ++ + E K V +EA V E +S + E+ +
Sbjct: 589 KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS 648
Query: 1142 MESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPK 1201
E K+ E ++ SPE + + K S E P +EA ++ V+ E + P+
Sbjct: 649 PEKAKSPEKEEAKSPEKAKSPVKAEAK-SPEKAKSPVKAEAKSPEKAKSPVKEE-AKSPE 706
Query: 1202 EESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQI-TDL 1260
+ + + +P P+ E P + +S +E E K ++ TL + +
Sbjct: 707 KAKSPVKEEAKSPEKAKSPVKEE-AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Query: 1261 GVSGAREEF---VETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQP 1317
+ A+EE + P + K ++ V + + ++ E E P
Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK----------EIP 815
Query: 1318 EVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETT 1377
+ E SP EEE + +E + K +APA+P+ EE S+ K E +
Sbjct: 816 KKEEVKSPVKEEE-KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPK 873
Query: 1378 IDDSIMDADSLWVDTQDDDRSIMTEQLETIP---KEEKAEKEARRSSLEKHRKEKPFKTG 1434
+++ A +++ + + E + +P KE A+ E + + K + E K
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 1435 RGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPA 1490
+ K A+K+ + + + + +KA KK E KTE +A + +P+
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKA--KKPEEKPKTEAKAKEDDKTLSKEPS 987
Score = 62.4 bits (150), Expect = 4e-09
Identities = 111/512 (21%), Positives = 197/512 (38%), Gaps = 64/512 (12%)
Query: 1066 RATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAV 1125
+ T + E T++ + + +E + E G +EG + E E E+ K +EA
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPA-EEAA 510
Query: 1126 DKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPP-------- 1177
E+ +S + E+ + K+ E ++ SP ++ E PP
Sbjct: 511 SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE 570
Query: 1178 -AVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSE- 1235
A S A++ + E+A + P +E ++P + +P P+ E S PAE +S
Sbjct: 571 EAKSPAEVKSPEKA-------KSPAKEEAKSPAEAKSPEKAKSPVKEEAKS-PAEAKSPV 622
Query: 1236 EEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVV 1295
+EE ++ E ++ + S +EE P + K + + + V
Sbjct: 623 KEEAKSPAE----------VKSPEKAKSPTKEE--AKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 1296 QTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPE 1355
+ E V+ A + PE + P +EE + E A++ + + SPE SP
Sbjct: 671 KAEAKSPEKAKSPVK-AEAKSPEKAKSPV---KEEAKSPEKAKSPVKEEAKSPEKAKSPV 726
Query: 1356 REEV-----ALSEYKTETYDDYKDETTIDDSIMDADSLWVDT--QDDDRS---IMTEQLE 1405
+EE A S K E K ++ +D S T +++ RS E+ +
Sbjct: 727 KEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK 786
Query: 1406 TIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVY 1465
+ KEE E +S L++ K PE+++ KKE E + + V
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAK------------APEKEIPKKEEVKSPVKEEEKPQEVK 834
Query: 1466 KKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKD 1525
K K E +A + + K + K P K++ E P+V K +
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAP------KKEAPKPKVEEKKEPAVEKPKES 888
Query: 1526 KVSDGVTKSPEKRSSLPRPSSILPPRRGVSGD 1557
KV + + E + +P P P + V D
Sbjct: 889 KV-EAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Score = 61.2 bits (147), Expect = 9e-09
Identities = 107/532 (20%), Positives = 195/532 (36%), Gaps = 46/532 (8%)
Query: 52 EDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQE 111
E+EE GE ++ + + + E A+ + A++ A +K ++
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 112 KEAQHKDQTAALPLAA---EETANLP-----PSPPPSPASEQTVTVEEDLLTASKMEFHD 163
++ K++ + P A +E A P P SPA E+ + E
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 164 QQELTPSTAEPSDQKEKESEKQSKPGEDLKHAAL--VSQPETTKTYPDKKDMQGTEEEKA 221
++ +P+ A+ ++E +S + K E K PE K+ P+K++ + E+ K+
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS-PEKEEAKSPEKAKS 668
Query: 222 PLALFGHTLVASLEDMKQ--KTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWG 279
P+ + + +K K+ P + K P K + P +AK
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK----- 723
Query: 280 LVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSP 339
+P+ TP + K + ++ P + LDV E T
Sbjct: 724 --SPVKEEAKTPEKAKSPVKE---------EAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772
Query: 340 FA--PAFLQPDDKKS--LQQTSGPATAKDSFK--IEEPHEAKPDKMAEAPPSEAMTLPKD 393
A PA P+ KS ++ P AK K + P + P K P + P++
Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 394 AHIP-----VVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQE--PILTEKETELKLE- 445
+ EE EEK+ +E +++ P +E EK E K+E
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA 892
Query: 446 EKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQ 505
+K DK+ VP P K A ++ + + + +E +EP K+ S P ++
Sbjct: 893 KKEEAEDKKKVP---TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949
Query: 506 AVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAE 557
A + T + K E K+ + + K K E ++S +
Sbjct: 950 AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001
Score = 56.2 bits (134), Expect = 3e-07
Identities = 119/554 (21%), Positives = 206/554 (37%), Gaps = 45/554 (8%)
Query: 1296 QTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEA-QAEPKDGSPEAPASP 1354
+T E ++ V E+ E E + EEE EE AE + E K E ASP
Sbjct: 453 ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP 512
Query: 1355 EREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAE 1414
E+E A S K E + ++ + V + + +S E+ ++ P+ + E
Sbjct: 513 EKE--AKSPVKEEAKSPAEAKSPEKEEAKSPAE--VKSPEKAKSPAKEEAKSPPEAKSPE 568
Query: 1415 KEARRSSLEKHRKEKPFKTGRGRISTP-ERKVAKKEPSTVSRDEVRRKKAVYKKAELAKK 1473
KE +S E EK + +P E K +K S V K+ AE
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV-------KEEAKSPAEAKSP 621
Query: 1474 TEVQAHSPSRKFILKPAIKYTRPTHLSCVK-RKTTAAGGESALAPSVFKQAKDKVSDGVT 1532
+ +A SP+ +K K PT K + E A +P ++AK V
Sbjct: 622 VKEEAKSPAE---VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP---EKAKSPVK-AEA 674
Query: 1533 KSPEKRSSLPRPSSILPPRRGVSGDRDE--NSFSLNSSISSSARRTTRSE-PIRRAGKSG 1589
KSPEK S P + P + S ++E + S + A+ +++ P++ K+
Sbjct: 675 KSPEKAKS-PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 1590 TSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAI--- 1646
+ A +P S +P +TP A P + K +
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE-AKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 1647 IRTPPKSPATPKQ-LRLINQPLPDLKNVKSKIGSTD-----NIKYQPKGGQVQ--IVTKK 1698
+++P K+ + K+ + + +P + VKS + + +K PK + + T K
Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852
Query: 1699 IDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHV-------PG 1751
+ + K + K +P K +V+ + K +AK ++ V P
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA 912
Query: 1752 GGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLLESPQL 1811
VK D++ E AK D P A+P + + + E P+
Sbjct: 913 KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEK-KDTKEEKAKKPEEKPKT 971
Query: 1812 ATLAEDVTAALAKQ 1825
A++ L+K+
Sbjct: 972 EAKAKEDDKTLSKE 985
Score = 52.0 bits (123), Expect = 5e-06
Identities = 124/647 (19%), Positives = 253/647 (39%), Gaps = 83/647 (12%)
Query: 806 LPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLE 865
LPE L + S V ++ ++ + ETV+ + +T VT+E V + + E
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEE----VTEEEEKE 477
Query: 866 DLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRV 925
+ ++ + G EG +++ + A + + E + A V
Sbjct: 478 ---------------AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKE--AKSPV 520
Query: 926 KDEFSVDKEAS----------AHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKE 975
K+E EA A + + S ++ K + E+++ A+ K
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 976 HAKKTEEAGDEIETFGLGVTYEQA---LAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSK 1032
K A +E ++ + E+A + ++ P +A S E+ S AEV+ +
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP----AEVKSPE 636
Query: 1033 KVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFM 1092
K + + K + + S ++ + +K EA +K+P +A+A
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKS----PEKAKSPVKAEAKSP--EKAKSPVKAEA-- 688
Query: 1093 GVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKK 1152
+S + E + EK P V +EA E++ +S + E+ T E K+ ++
Sbjct: 689 --KSPEKAKSPVKEEAKSPEKAKSP--VKEEAKSPEKA-KSPVKEEAKTPEKAKSPVKEE 743
Query: 1153 ETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISI 1212
SPE + ++ ++++ P A + A AD E + P +E ++P+ +
Sbjct: 744 AKSPEKAKSPEKAK---TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK 800
Query: 1213 TP---------------SDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQI 1257
+P +V P+ E +P E++ +E +A+ E ++
Sbjct: 801 SPLKEDAKAPEKEIPKKEEVKSPVKEE--EKPQEVKVKEPPKKAEEE------KAPATPK 852
Query: 1258 TDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQP 1317
T+ +EE + + K + +E + V+ +E E V E P
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED-KKKVPTPEKEAP 911
Query: 1318 ---EVERRPSPHDEEEFEVEEAAEAQA-EPKDGSPEAPASPEREEVALSEYKT-ETYDDY 1372
EV+ P ++ E +E +A+A EP + + A+PE+++ + K E
Sbjct: 912 AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKT 971
Query: 1373 KDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARR 1419
+ + DD + + + ++S T+Q ++ P E+ E +A +
Sbjct: 972 EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAK 1018
Score = 32.3 bits (72), Expect = 4.3
Identities = 48/225 (21%), Positives = 86/225 (38%), Gaps = 21/225 (9%)
Query: 6 KDEAKAPHWTSAPLTEASA----HSHPPEIKDQGGAGEGLVRSANGFPYREDE-----EG 56
K++AKAP E + P E+K + + A P E++ E
Sbjct: 804 KEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 57 AFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQH 116
A + + KE + S EE + +V T E A K E +++A+
Sbjct: 864 APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK-KKVPTPEKEAPAKVEVKEDAKP 922
Query: 117 KDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSD 176
K++T +A +E + P PA ++ E K + +++ P ++
Sbjct: 923 KEKTE---VAKKEPDDAKAKEPSKPAEKKEAAPE-------KKDTKEEKAKKPEEKPKTE 972
Query: 177 QKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKA 221
K KE +K + E K A ++ ++ D K + E+KA
Sbjct: 973 AKAKEDDK-TLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 64.3 bits (155), Expect = 1e-09
Identities = 108/463 (23%), Positives = 156/463 (33%), Gaps = 62/463 (13%)
Query: 78 ELTSADRETAEEVS--ARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPP 135
E S ++ +A++++ ++++ T +A KG K+ T P E + P
Sbjct: 175 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTP--KEPTPTTP--KEPASTTPK 230
Query: 136 SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAE---PSDQKEKESEKQSKPGEDL 192
P P+ T +E T +K +E P+T + P+ KE +P
Sbjct: 231 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 290
Query: 193 KHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDL 252
+A + E T P KK T +E AP T P P
Sbjct: 291 TKSAPTTPKEPAPTTP-KKPAPTTPKEPAP------------------TTPKEPTP--TT 329
Query: 253 PKEP-PTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDS 311
PKEP PT KE P E AP P P TP K+ PK
Sbjct: 330 PKEPAPTTKE--------PAPTTPKEPAPTAPKKPAPTTP---KEPAPTTPK-------E 371
Query: 312 PMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTS---GPATAKDSFKI 368
P P+ + S T P + T+++P P KS T P T K+
Sbjct: 372 PAPTTTKEPSPTTPKEPAPT--TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 429
Query: 369 --EEPHEAKPDKMAEAPPSE-AMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV----Q 421
+EP P K A P E A T PK+ P + +E +ET +
Sbjct: 430 TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPK 488
Query: 422 QRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTF 481
+ TP P EK EE + +E P + P P + T E
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 548
Query: 482 SEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEP 524
+ K+ PTT + P + E A T P
Sbjct: 549 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 591
Score = 53.9 bits (128), Expect = 1e-06
Identities = 100/448 (22%), Positives = 148/448 (33%), Gaps = 72/448 (16%)
Query: 124 PLAAEETA-NLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKES 182
P E+ A P P P+ E T E+ + E TP A P+ KE
Sbjct: 492 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE---PAPTTPKAAAPNTPKEPAP 548
Query: 183 EKQSKPGEDL-KHAALVSQPETTKTYPD-------KKDMQGTEEEKAPLALFGHTLVASL 234
+P K A + ET T P K+ T ++ AP L T
Sbjct: 549 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT---- 604
Query: 235 EDMKQKTEPSLVVPGIDLPK--EPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPM 292
K+ T + P PK P TPKE + P P P TP
Sbjct: 605 ---KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 661
Query: 293 RE--KDVFDDIPKWE-GKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDD 349
+ K++ K D P P+ + + T P + T+P PA P+
Sbjct: 662 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP------APTTPKKPAPTTPET 715
Query: 350 KK-SLQQTSGPATAKDSFKIEE-PHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKV 407
+ + S P T K+ I + P E+ P+ AE P PK+ +P
Sbjct: 716 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT--------- 766
Query: 408 LEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPK-ESKPPKPA 466
T TP+ +P +T ++KTT D P+ + PK
Sbjct: 767 -----------------TKTPAATKPEMT-----TTAKDKTTERDLRTTPETTTAAPKMT 804
Query: 467 DEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSA 526
E + +TE + Q T QD+ P + + + + TL +T
Sbjct: 805 KETATTTEKTTESKITATTTQ--VTSTTTQDTTPFKI------TTLKTTTLAPKVTTTKK 856
Query: 527 LIEKSSIQELFEMRVDDKDKIEGVGAAT 554
I + I E KD+ A T
Sbjct: 857 TITTTEIMNKPEETAKPKDRATNSKATT 884
Score = 52.8 bits (125), Expect = 3e-06
Identities = 98/445 (22%), Positives = 146/445 (32%), Gaps = 70/445 (15%)
Query: 115 QHKDQTAALPLAAEETANLPPS-PPPSPASEQT-------VTVE-EDLLTASKMEFHDQQ 165
QH + + + + N PS PP S S++T TVE ++ T +K D +
Sbjct: 108 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 167
Query: 166 ELTPSTAEPSDQKEKESEKQSKPGEDL------------KHAALVSQPETTKTYPDKKDM 213
E T S E + EK S K P + K AL + E T T P K+
Sbjct: 168 EKTTSAKE-TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPA 225
Query: 214 QGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEA 273
T +E P T + S ++ P+ PKEP PT
Sbjct: 226 STTPKEPTP------TTIKSAPTTPKEPAPTTTKSAPTTPKEPA------------PTTT 267
Query: 274 KKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEI 333
K+ AP +P P K+ K P P+ + + T P +
Sbjct: 268 KEP-----APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP----- 317
Query: 334 VTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSE-AMTLPK 392
T+P P P + + P T K EP P K A P E A T PK
Sbjct: 318 -APTTPKEPTPTTPKEPAPTTKEPAPTTPK------EPAPTAPKKPAPTTPKEPAPTTPK 370
Query: 393 DAHIPVVEEHVMGKVLEEEKEAINQE----------TVQQRDTFTPSGQEPILTEKETEL 442
+ P + +E + T + TP P T++
Sbjct: 371 EP-APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 429
Query: 443 KLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVS 502
+E + K+ P K P P + T+ + + K+ PTT + P
Sbjct: 430 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKK 489
Query: 503 LEQAVTDSAMTSKTLEKAMTEPSAL 527
L + + + A T P L
Sbjct: 490 LTPTTPEKLAPTTPEKPAPTTPEEL 514
Score = 44.3 bits (103), Expect = 0.001
Identities = 76/373 (20%), Positives = 130/373 (34%), Gaps = 36/373 (9%)
Query: 1317 PEVERRPSPHDEEEFEVE--EAAEAQAEPKDGSPEA----PASPEREEVALSEYKTETYD 1370
P V+ S D +F+V + + Q SP+ P +P S+ ET
Sbjct: 83 PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSL 142
Query: 1371 DYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKP 1430
ETT++ + T +++ ++ ++I K + L K +
Sbjct: 143 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 202
Query: 1431 FKTGRGRISTPERKV--AKKEPSTVSRDE---VRRKKAVYKKAELAKKTEVQAHSPSRKF 1485
T ++TP+ KEP++ + E K A E A T A + ++
Sbjct: 203 TTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE- 261
Query: 1486 ILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRS------ 1539
PA T+ + K E A P+ K A + +P+K +
Sbjct: 262 ---PAPTTTKEPAPTTPKEPAPTTTKEPA--PTTTKSAPTTPKEPAPTTPKKPAPTTPKE 316
Query: 1540 ---SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARR---TTRSEPIRRAGKSGTST- 1592
+ P+ + P+ ++ + ++ ++ TT EP K T
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376
Query: 1593 -----PTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAII 1647
PTTP A T +++ P T S P TP P + P+ K
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436
Query: 1648 RTPPK-SPATPKQ 1659
TP K +P TPK+
Sbjct: 437 TTPKKPAPTTPKE 449
Score = 41.6 bits (96), Expect = 0.007
Identities = 83/373 (22%), Positives = 123/373 (32%), Gaps = 35/373 (9%)
Query: 1322 RPSPHDEEEFEVEEAAEAQAEPKDGSPE-----APASPEREEVALSEYKTETYDDYKDET 1376
+ +P +E A PK+ SP AP +P+ + T T
Sbjct: 394 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 453
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRG 1436
T + T + + T + ET P K L EKP T
Sbjct: 454 TPKEPAPTTTKKPAPTTPKEPAPTTPK-ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 512
Query: 1437 RIS--TPERKV--AKKEPSTVS----RDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILK 1488
++ TPE +EP+ + ++ A E A T + + K
Sbjct: 513 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 572
Query: 1489 PAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSS--LPR-PS 1545
K T PT L T LAP+ K+ D + K ++ P+ P+
Sbjct: 573 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 632
Query: 1546 SILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTST------PTTPGST 1599
P + + +L ++ ++ E K TST PTTP T
Sbjct: 633 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 692
Query: 1600 AITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKK--VAIIRTP----PKS 1653
A P TP + TP P P TP TP S + P+ K I ++P P+
Sbjct: 693 A--PTTPKEPAPTTPKKPA----PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 746
Query: 1654 PATPKQLRLINQP 1666
A P L N P
Sbjct: 747 SAEPTPKALENSP 759
Score = 40.4 bits (93), Expect = 0.016
Identities = 84/392 (21%), Positives = 139/392 (35%), Gaps = 33/392 (8%)
Query: 1292 ITVVQTTTDEGESGSHSVRFAALE--QPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSP- 1348
+T T+T + S S + + P P+ +E + E E K+ +
Sbjct: 99 VTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT 158
Query: 1349 EAPASPEREEVALSEYKTETYDDYKDETTIDDS-IMDADSLWVDTQDDDRSIMT--EQLE 1405
S + +E S +T++ + + S ++ + +T ++ T E
Sbjct: 159 NKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTP 218
Query: 1406 TIPKEEKAE--KEARRSSLEKHR---KEKPFKTGRGRISTPERKV--AKKEPSTVSRDEV 1458
T PKE + KE ++++ KE T + +TP+ KEP+ + E
Sbjct: 219 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 278
Query: 1459 RRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPS 1518
K P+ KPA + + K T E A P+
Sbjct: 279 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA--PT 336
Query: 1519 VFKQAKDKVSDGVTKSPEKRS-SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTT 1577
+ A + +P+K + + P+ + P+ E S ++ A TT
Sbjct: 337 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS---PTTPKEPAPTTT 393
Query: 1578 RS------EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPG- 1630
+S EP KS +TP P T P + P TP P+ P TP P
Sbjct: 394 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA-PTTPKEPAP 452
Query: 1631 -TPKSAILVPSEKKVAIIRTPPKSPA--TPKQ 1659
TPK ++K T PK PA TPK+
Sbjct: 453 TTPKEPAPTTTKKPAP---TTPKEPAPTTPKE 481
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 64.3 bits (155), Expect = 1e-09
Identities = 108/463 (23%), Positives = 156/463 (33%), Gaps = 62/463 (13%)
Query: 78 ELTSADRETAEEVS--ARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPP 135
E S ++ +A++++ ++++ T +A KG K+ T P E + P
Sbjct: 216 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTP--KEPTPTTP--KEPASTTPK 271
Query: 136 SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAE---PSDQKEKESEKQSKPGEDL 192
P P+ T +E T +K +E P+T + P+ KE +P
Sbjct: 272 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 331
Query: 193 KHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDL 252
+A + E T P KK T +E AP T P P
Sbjct: 332 TKSAPTTPKEPAPTTP-KKPAPTTPKEPAP------------------TTPKEPTP--TT 370
Query: 253 PKEP-PTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDS 311
PKEP PT KE P E AP P P TP K+ PK
Sbjct: 371 PKEPAPTTKE--------PAPTTPKEPAPTAPKKPAPTTP---KEPAPTTPK-------E 412
Query: 312 PMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTS---GPATAKDSFKI 368
P P+ + S T P + T+++P P KS T P T K+
Sbjct: 413 PAPTTTKEPSPTTPKEPAPT--TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 470
Query: 369 --EEPHEAKPDKMAEAPPSE-AMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV----Q 421
+EP P K A P E A T PK+ P + +E +ET +
Sbjct: 471 TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPK 529
Query: 422 QRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTF 481
+ TP P EK EE + +E P + P P + T E
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 589
Query: 482 SEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEP 524
+ K+ PTT + P + E A T P
Sbjct: 590 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 632
Score = 53.9 bits (128), Expect = 1e-06
Identities = 100/448 (22%), Positives = 148/448 (33%), Gaps = 72/448 (16%)
Query: 124 PLAAEETA-NLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKES 182
P E+ A P P P+ E T E+ + E TP A P+ KE
Sbjct: 533 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE---PAPTTPKAAAPNTPKEPAP 589
Query: 183 EKQSKPGEDL-KHAALVSQPETTKTYPD-------KKDMQGTEEEKAPLALFGHTLVASL 234
+P K A + ET T P K+ T ++ AP L T
Sbjct: 590 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT---- 645
Query: 235 EDMKQKTEPSLVVPGIDLPK--EPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPM 292
K+ T + P PK P TPKE + P P P TP
Sbjct: 646 ---KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 702
Query: 293 RE--KDVFDDIPKWE-GKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDD 349
+ K++ K D P P+ + + T P + T+P PA P+
Sbjct: 703 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP------APTTPKKPAPTTPET 756
Query: 350 KK-SLQQTSGPATAKDSFKIEE-PHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKV 407
+ + S P T K+ I + P E+ P+ AE P PK+ +P
Sbjct: 757 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT--------- 807
Query: 408 LEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPK-ESKPPKPA 466
T TP+ +P +T ++KTT D P+ + PK
Sbjct: 808 -----------------TKTPAATKPEMT-----TTAKDKTTERDLRTTPETTTAAPKMT 845
Query: 467 DEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSA 526
E + +TE + Q T QD+ P + + + + TL +T
Sbjct: 846 KETATTTEKTTESKITATTTQ--VTSTTTQDTTPFKI------TTLKTTTLAPKVTTTKK 897
Query: 527 LIEKSSIQELFEMRVDDKDKIEGVGAAT 554
I + I E KD+ A T
Sbjct: 898 TITTTEIMNKPEETAKPKDRATNSKATT 925
Score = 52.8 bits (125), Expect = 3e-06
Identities = 98/445 (22%), Positives = 146/445 (32%), Gaps = 70/445 (15%)
Query: 115 QHKDQTAALPLAAEETANLPPS-PPPSPASEQT-------VTVE-EDLLTASKMEFHDQQ 165
QH + + + + N PS PP S S++T TVE ++ T +K D +
Sbjct: 149 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 208
Query: 166 ELTPSTAEPSDQKEKESEKQSKPGEDL------------KHAALVSQPETTKTYPDKKDM 213
E T S E + EK S K P + K AL + E T T P K+
Sbjct: 209 EKTTSAKE-TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPA 266
Query: 214 QGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEA 273
T +E P T + S ++ P+ PKEP PT
Sbjct: 267 STTPKEPTP------TTIKSAPTTPKEPAPTTTKSAPTTPKEPA------------PTTT 308
Query: 274 KKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEI 333
K+ AP +P P K+ K P P+ + + T P +
Sbjct: 309 KEP-----APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP----- 358
Query: 334 VTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSE-AMTLPK 392
T+P P P + + P T K EP P K A P E A T PK
Sbjct: 359 -APTTPKEPTPTTPKEPAPTTKEPAPTTPK------EPAPTAPKKPAPTTPKEPAPTTPK 411
Query: 393 DAHIPVVEEHVMGKVLEEEKEAINQE----------TVQQRDTFTPSGQEPILTEKETEL 442
+ P + +E + T + TP P T++
Sbjct: 412 EP-APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 470
Query: 443 KLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVS 502
+E + K+ P K P P + T+ + + K+ PTT + P
Sbjct: 471 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKK 530
Query: 503 LEQAVTDSAMTSKTLEKAMTEPSAL 527
L + + + A T P L
Sbjct: 531 LTPTTPEKLAPTTPEKPAPTTPEEL 555
Score = 44.3 bits (103), Expect = 0.001
Identities = 76/373 (20%), Positives = 130/373 (34%), Gaps = 36/373 (9%)
Query: 1317 PEVERRPSPHDEEEFEVE--EAAEAQAEPKDGSPEA----PASPEREEVALSEYKTETYD 1370
P V+ S D +F+V + + Q SP+ P +P S+ ET
Sbjct: 124 PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSL 183
Query: 1371 DYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKP 1430
ETT++ + T +++ ++ ++I K + L K +
Sbjct: 184 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAE 243
Query: 1431 FKTGRGRISTPERKV--AKKEPSTVSRDE---VRRKKAVYKKAELAKKTEVQAHSPSRKF 1485
T ++TP+ KEP++ + E K A E A T A + ++
Sbjct: 244 TTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE- 302
Query: 1486 ILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRS------ 1539
PA T+ + K E A P+ K A + +P+K +
Sbjct: 303 ---PAPTTTKEPAPTTPKEPAPTTTKEPA--PTTTKSAPTTPKEPAPTTPKKPAPTTPKE 357
Query: 1540 ---SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARR---TTRSEPIRRAGKSGTST- 1592
+ P+ + P+ ++ + ++ ++ TT EP K T
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417
Query: 1593 -----PTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAII 1647
PTTP A T +++ P T S P TP P + P+ K
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477
Query: 1648 RTPPK-SPATPKQ 1659
TP K +P TPK+
Sbjct: 478 TTPKKPAPTTPKE 490
Score = 41.6 bits (96), Expect = 0.007
Identities = 83/373 (22%), Positives = 123/373 (32%), Gaps = 35/373 (9%)
Query: 1322 RPSPHDEEEFEVEEAAEAQAEPKDGSPE-----APASPEREEVALSEYKTETYDDYKDET 1376
+ +P +E A PK+ SP AP +P+ + T T
Sbjct: 435 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 494
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRG 1436
T + T + + T + ET P K L EKP T
Sbjct: 495 TPKEPAPTTTKKPAPTTPKEPAPTTPK-ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 553
Query: 1437 RIS--TPERKV--AKKEPSTVS----RDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILK 1488
++ TPE +EP+ + ++ A E A T + + K
Sbjct: 554 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 613
Query: 1489 PAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSS--LPR-PS 1545
K T PT L T LAP+ K+ D + K ++ P+ P+
Sbjct: 614 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 673
Query: 1546 SILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTST------PTTPGST 1599
P + + +L ++ ++ E K TST PTTP T
Sbjct: 674 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 733
Query: 1600 AITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKK--VAIIRTP----PKS 1653
A P TP + TP P P TP TP S + P+ K I ++P P+
Sbjct: 734 A--PTTPKEPAPTTPKKPA----PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 787
Query: 1654 PATPKQLRLINQP 1666
A P L N P
Sbjct: 788 SAEPTPKALENSP 800
Score = 40.4 bits (93), Expect = 0.016
Identities = 84/392 (21%), Positives = 139/392 (35%), Gaps = 33/392 (8%)
Query: 1292 ITVVQTTTDEGESGSHSVRFAALE--QPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSP- 1348
+T T+T + S S + + P P+ +E + E E K+ +
Sbjct: 140 VTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT 199
Query: 1349 EAPASPEREEVALSEYKTETYDDYKDETTIDDS-IMDADSLWVDTQDDDRSIMT--EQLE 1405
S + +E S +T++ + + S ++ + +T ++ T E
Sbjct: 200 NKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTP 259
Query: 1406 TIPKEEKAE--KEARRSSLEKHR---KEKPFKTGRGRISTPERKV--AKKEPSTVSRDEV 1458
T PKE + KE ++++ KE T + +TP+ KEP+ + E
Sbjct: 260 TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEP 319
Query: 1459 RRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPS 1518
K P+ KPA + + K T E A P+
Sbjct: 320 APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA--PT 377
Query: 1519 VFKQAKDKVSDGVTKSPEKRS-SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTT 1577
+ A + +P+K + + P+ + P+ E S ++ A TT
Sbjct: 378 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS---PTTPKEPAPTTT 434
Query: 1578 RS------EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPG- 1630
+S EP KS +TP P T P + P TP P+ P TP P
Sbjct: 435 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA-PTTPKEPAP 493
Query: 1631 -TPKSAILVPSEKKVAIIRTPPKSPA--TPKQ 1659
TPK ++K T PK PA TPK+
Sbjct: 494 TTPKEPAPTTTKKPAP---TTPKEPAPTTPKE 522
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 64.3 bits (155), Expect = 1e-09
Identities = 108/463 (23%), Positives = 156/463 (33%), Gaps = 62/463 (13%)
Query: 78 ELTSADRETAEEVS--ARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPP 135
E S ++ +A++++ ++++ T +A KG K+ T P E + P
Sbjct: 268 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTP--KEPTPTTP--KEPASTTPK 323
Query: 136 SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAE---PSDQKEKESEKQSKPGEDL 192
P P+ T +E T +K +E P+T + P+ KE +P
Sbjct: 324 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 383
Query: 193 KHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDL 252
+A + E T P KK T +E AP T P P
Sbjct: 384 TKSAPTTPKEPAPTTP-KKPAPTTPKEPAP------------------TTPKEPTP--TT 422
Query: 253 PKEP-PTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDS 311
PKEP PT KE P E AP P P TP K+ PK
Sbjct: 423 PKEPAPTTKE--------PAPTTPKEPAPTAPKKPAPTTP---KEPAPTTPK-------E 464
Query: 312 PMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTS---GPATAKDSFKI 368
P P+ + S T P + T+++P P KS T P T K+
Sbjct: 465 PAPTTTKEPSPTTPKEPAPT--TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 522
Query: 369 --EEPHEAKPDKMAEAPPSE-AMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV----Q 421
+EP P K A P E A T PK+ P + +E +ET +
Sbjct: 523 TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPK 581
Query: 422 QRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTF 481
+ TP P EK EE + +E P + P P + T E
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 641
Query: 482 SEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEP 524
+ K+ PTT + P + E A T P
Sbjct: 642 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 684
Score = 53.9 bits (128), Expect = 1e-06
Identities = 100/448 (22%), Positives = 148/448 (33%), Gaps = 72/448 (16%)
Query: 124 PLAAEETA-NLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKES 182
P E+ A P P P+ E T E+ + E TP A P+ KE
Sbjct: 585 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE---PAPTTPKAAAPNTPKEPAP 641
Query: 183 EKQSKPGEDL-KHAALVSQPETTKTYPD-------KKDMQGTEEEKAPLALFGHTLVASL 234
+P K A + ET T P K+ T ++ AP L T
Sbjct: 642 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT---- 697
Query: 235 EDMKQKTEPSLVVPGIDLPK--EPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPM 292
K+ T + P PK P TPKE + P P P TP
Sbjct: 698 ---KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 754
Query: 293 RE--KDVFDDIPKWE-GKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDD 349
+ K++ K D P P+ + + T P + T+P PA P+
Sbjct: 755 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP------APTTPKKPAPTTPET 808
Query: 350 KK-SLQQTSGPATAKDSFKIEE-PHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKV 407
+ + S P T K+ I + P E+ P+ AE P PK+ +P
Sbjct: 809 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT--------- 859
Query: 408 LEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPK-ESKPPKPA 466
T TP+ +P +T ++KTT D P+ + PK
Sbjct: 860 -----------------TKTPAATKPEMT-----TTAKDKTTERDLRTTPETTTAAPKMT 897
Query: 467 DEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSA 526
E + +TE + Q T QD+ P + + + + TL +T
Sbjct: 898 KETATTTEKTTESKITATTTQ--VTSTTTQDTTPFKI------TTLKTTTLAPKVTTTKK 949
Query: 527 LIEKSSIQELFEMRVDDKDKIEGVGAAT 554
I + I E KD+ A T
Sbjct: 950 TITTTEIMNKPEETAKPKDRATNSKATT 977
Score = 52.8 bits (125), Expect = 3e-06
Identities = 98/445 (22%), Positives = 146/445 (32%), Gaps = 70/445 (15%)
Query: 115 QHKDQTAALPLAAEETANLPPS-PPPSPASEQT-------VTVE-EDLLTASKMEFHDQQ 165
QH + + + + N PS PP S S++T TVE ++ T +K D +
Sbjct: 201 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 260
Query: 166 ELTPSTAEPSDQKEKESEKQSKPGEDL------------KHAALVSQPETTKTYPDKKDM 213
E T S E + EK S K P + K AL + E T T P K+
Sbjct: 261 EKTTSAKE-TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPA 318
Query: 214 QGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEA 273
T +E P T + S ++ P+ PKEP PT
Sbjct: 319 STTPKEPTP------TTIKSAPTTPKEPAPTTTKSAPTTPKEPA------------PTTT 360
Query: 274 KKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEI 333
K+ AP +P P K+ K P P+ + + T P +
Sbjct: 361 KEP-----APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP----- 410
Query: 334 VTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSE-AMTLPK 392
T+P P P + + P T K EP P K A P E A T PK
Sbjct: 411 -APTTPKEPTPTTPKEPAPTTKEPAPTTPK------EPAPTAPKKPAPTTPKEPAPTTPK 463
Query: 393 DAHIPVVEEHVMGKVLEEEKEAINQE----------TVQQRDTFTPSGQEPILTEKETEL 442
+ P + +E + T + TP P T++
Sbjct: 464 EP-APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 522
Query: 443 KLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVS 502
+E + K+ P K P P + T+ + + K+ PTT + P
Sbjct: 523 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKK 582
Query: 503 LEQAVTDSAMTSKTLEKAMTEPSAL 527
L + + + A T P L
Sbjct: 583 LTPTTPEKLAPTTPEKPAPTTPEEL 607
Score = 51.2 bits (121), Expect = 9e-06
Identities = 134/610 (21%), Positives = 200/610 (32%), Gaps = 141/610 (23%)
Query: 1081 SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL 1140
S KAP + A S +K TK S +K K ++ E + +E S + E S
Sbjct: 75 SKKAPPPSGA-----SQTIKSTTKRSPKPPNKKKTKK-VIESEEITEEHSVSENQESSSS 128
Query: 1141 TMESLKADEGKKETSPESSLIQDEIAVKLSVE-----------IPCPPAVSEADLATDER 1189
+ S + +K S ++S E+ KL V+ P PP V EA D
Sbjct: 129 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 188
Query: 1190 ADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLL 1249
D +T D + H + + P ++ L
Sbjct: 189 -------------------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS-----LP 224
Query: 1250 FRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSV 1309
SDT + T L V+ +E VET ++ T QT+TD E + +
Sbjct: 225 PNSDTSKETSLTVN--KETTVET---------------KETTTTNKQTSTDGKEKTTSAK 267
Query: 1310 RFAALEQP---------EVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVA 1360
++E+ +V +P+P + E A PK+ +P P P A
Sbjct: 268 ETQSIEKTSAKDLAPTSKVLAKPTP----KAETTTKGPALTTPKEPTPTTPKEP-----A 318
Query: 1361 LSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRS 1420
+ K T K T T + T+ T PKE
Sbjct: 319 STTPKEPTPTTIKSAPT--------------TPKEPAPTTTKSAPTTPKEPA-------- 356
Query: 1421 SLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHS 1480
P T +TP KEP+ + E K
Sbjct: 357 ---------PTTTKEPAPTTP------KEPAPTTTKE--------PAPTTTKSAPTTPKE 393
Query: 1481 PSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRS- 1539
P+ KPA + + K T E A P+ + A + +P+K +
Sbjct: 394 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA--PTTKEPAPTTPKEPAPTAPKKPAP 451
Query: 1540 SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRS------EPIRRAGKSGTSTP 1593
+ P+ + P+ E S ++ A TT+S EP KS +TP
Sbjct: 452 TTPKEPAPTTPKEPAPTTTKEPS---PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 508
Query: 1594 TTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPG--TPKSAILVPSEKKVAIIRTPP 1651
P T P + P TP P+ P TP P TPK ++K T P
Sbjct: 509 KEPSPTTTKEPAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAP---TTP 564
Query: 1652 KSPA--TPKQ 1659
K PA TPK+
Sbjct: 565 KEPAPTTPKE 574
Score = 41.6 bits (96), Expect = 0.007
Identities = 83/373 (22%), Positives = 123/373 (32%), Gaps = 35/373 (9%)
Query: 1322 RPSPHDEEEFEVEEAAEAQAEPKDGSPE-----APASPEREEVALSEYKTETYDDYKDET 1376
+ +P +E A PK+ SP AP +P+ + T T
Sbjct: 487 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 546
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRG 1436
T + T + + T + ET P K L EKP T
Sbjct: 547 TPKEPAPTTTKKPAPTTPKEPAPTTPK-ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 605
Query: 1437 RIS--TPERKV--AKKEPSTVS----RDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILK 1488
++ TPE +EP+ + ++ A E A T + + K
Sbjct: 606 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 665
Query: 1489 PAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSS--LPR-PS 1545
K T PT L T LAP+ K+ D + K ++ P+ P+
Sbjct: 666 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725
Query: 1546 SILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTST------PTTPGST 1599
P + + +L ++ ++ E K TST PTTP T
Sbjct: 726 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 785
Query: 1600 AITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKK--VAIIRTP----PKS 1653
A P TP + TP P P TP TP S + P+ K I ++P P+
Sbjct: 786 A--PTTPKEPAPTTPKKPA----PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 839
Query: 1654 PATPKQLRLINQP 1666
A P L N P
Sbjct: 840 SAEPTPKALENSP 852
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 64.3 bits (155), Expect = 1e-09
Identities = 108/463 (23%), Positives = 156/463 (33%), Gaps = 62/463 (13%)
Query: 78 ELTSADRETAEEVS--ARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPP 135
E S ++ +A++++ ++++ T +A KG K+ T P E + P
Sbjct: 309 ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTP--KEPTPTTP--KEPASTTPK 364
Query: 136 SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAE---PSDQKEKESEKQSKPGEDL 192
P P+ T +E T +K +E P+T + P+ KE +P
Sbjct: 365 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTT 424
Query: 193 KHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDL 252
+A + E T P KK T +E AP T P P
Sbjct: 425 TKSAPTTPKEPAPTTP-KKPAPTTPKEPAP------------------TTPKEPTP--TT 463
Query: 253 PKEP-PTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDS 311
PKEP PT KE P E AP P P TP K+ PK
Sbjct: 464 PKEPAPTTKE--------PAPTTPKEPAPTAPKKPAPTTP---KEPAPTTPK-------E 505
Query: 312 PMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTS---GPATAKDSFKI 368
P P+ + S T P + T+++P P KS T P T K+
Sbjct: 506 PAPTTTKEPSPTTPKEPAPT--TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 563
Query: 369 --EEPHEAKPDKMAEAPPSE-AMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETV----Q 421
+EP P K A P E A T PK+ P + +E +ET +
Sbjct: 564 TPKEPAPTTPKKPAPTTPKEPAPTTPKEP-APTTTKKPAPTTPKEPAPTTPKETAPTTPK 622
Query: 422 QRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTF 481
+ TP P EK EE + +E P + P P + T E
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAP 682
Query: 482 SEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEP 524
+ K+ PTT + P + E A T P
Sbjct: 683 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTP 725
Score = 53.9 bits (128), Expect = 1e-06
Identities = 100/448 (22%), Positives = 148/448 (33%), Gaps = 72/448 (16%)
Query: 124 PLAAEETA-NLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKES 182
P E+ A P P P+ E T E+ + E TP A P+ KE
Sbjct: 626 PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE---PAPTTPKAAAPNTPKEPAP 682
Query: 183 EKQSKPGEDL-KHAALVSQPETTKTYPD-------KKDMQGTEEEKAPLALFGHTLVASL 234
+P K A + ET T P K+ T ++ AP L T
Sbjct: 683 TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT---- 738
Query: 235 EDMKQKTEPSLVVPGIDLPK--EPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPM 292
K+ T + P PK P TPKE + P P P TP
Sbjct: 739 ---KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPK 795
Query: 293 RE--KDVFDDIPKWE-GKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDD 349
+ K++ K D P P+ + + T P + T+P PA P+
Sbjct: 796 KPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP------APTTPKKPAPTTPET 849
Query: 350 KK-SLQQTSGPATAKDSFKIEE-PHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKV 407
+ + S P T K+ I + P E+ P+ AE P PK+ +P
Sbjct: 850 PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT--------- 900
Query: 408 LEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPK-ESKPPKPA 466
T TP+ +P +T ++KTT D P+ + PK
Sbjct: 901 -----------------TKTPAATKPEMT-----TTAKDKTTERDLRTTPETTTAAPKMT 938
Query: 467 DEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSA 526
E + +TE + Q T QD+ P + + + + TL +T
Sbjct: 939 KETATTTEKTTESKITATTTQ--VTSTTTQDTTPFKI------TTLKTTTLAPKVTTTKK 990
Query: 527 LIEKSSIQELFEMRVDDKDKIEGVGAAT 554
I + I E KD+ A T
Sbjct: 991 TITTTEIMNKPEETAKPKDRATNSKATT 1018
Score = 52.8 bits (125), Expect = 3e-06
Identities = 98/445 (22%), Positives = 146/445 (32%), Gaps = 70/445 (15%)
Query: 115 QHKDQTAALPLAAEETANLPPS-PPPSPASEQT-------VTVE-EDLLTASKMEFHDQQ 165
QH + + + + N PS PP S S++T TVE ++ T +K D +
Sbjct: 242 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 301
Query: 166 ELTPSTAEPSDQKEKESEKQSKPGEDL------------KHAALVSQPETTKTYPDKKDM 213
E T S E + EK S K P + K AL + E T T P K+
Sbjct: 302 EKTTSAKE-TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTP-KEPA 359
Query: 214 QGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEA 273
T +E P T + S ++ P+ PKEP PT
Sbjct: 360 STTPKEPTP------TTIKSAPTTPKEPAPTTTKSAPTTPKEPA------------PTTT 401
Query: 274 KKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEI 333
K+ AP +P P K+ K P P+ + + T P +
Sbjct: 402 KEP-----APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP----- 451
Query: 334 VTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSE-AMTLPK 392
T+P P P + + P T K EP P K A P E A T PK
Sbjct: 452 -APTTPKEPTPTTPKEPAPTTKEPAPTTPK------EPAPTAPKKPAPTTPKEPAPTTPK 504
Query: 393 DAHIPVVEEHVMGKVLEEEKEAINQE----------TVQQRDTFTPSGQEPILTEKETEL 442
+ P + +E + T + TP P T++
Sbjct: 505 EP-APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 563
Query: 443 KLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVS 502
+E + K+ P K P P + T+ + + K+ PTT + P
Sbjct: 564 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKK 623
Query: 503 LEQAVTDSAMTSKTLEKAMTEPSAL 527
L + + + A T P L
Sbjct: 624 LTPTTPEKLAPTTPEKPAPTTPEEL 648
Score = 51.2 bits (121), Expect = 9e-06
Identities = 134/610 (21%), Positives = 200/610 (32%), Gaps = 141/610 (23%)
Query: 1081 SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL 1140
S KAP + A S +K TK S +K K ++ E + +E S + E S
Sbjct: 116 SKKAPPPSGA-----SQTIKSTTKRSPKPPNKKKTKK-VIESEEITEEHSVSENQESSSS 169
Query: 1141 TMESLKADEGKKETSPESSLIQDEIAVKLSVE-----------IPCPPAVSEADLATDER 1189
+ S + +K S ++S E+ KL V+ P PP V EA D
Sbjct: 170 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNG 229
Query: 1190 ADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLL 1249
D +T D + H + + P ++ L
Sbjct: 230 -------------------DFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS-----LP 265
Query: 1250 FRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSV 1309
SDT + T L V+ +E VET ++ T QT+TD E + +
Sbjct: 266 PNSDTSKETSLTVN--KETTVET---------------KETTTTNKQTSTDGKEKTTSAK 308
Query: 1310 RFAALEQP---------EVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVA 1360
++E+ +V +P+P + E A PK+ +P P P A
Sbjct: 309 ETQSIEKTSAKDLAPTSKVLAKPTP----KAETTTKGPALTTPKEPTPTTPKEP-----A 359
Query: 1361 LSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRS 1420
+ K T K T T + T+ T PKE
Sbjct: 360 STTPKEPTPTTIKSAPT--------------TPKEPAPTTTKSAPTTPKEPA-------- 397
Query: 1421 SLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHS 1480
P T +TP KEP+ + E K
Sbjct: 398 ---------PTTTKEPAPTTP------KEPAPTTTKE--------PAPTTTKSAPTTPKE 434
Query: 1481 PSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRS- 1539
P+ KPA + + K T E A P+ + A + +P+K +
Sbjct: 435 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPA--PTTKEPAPTTPKEPAPTAPKKPAP 492
Query: 1540 SLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRS------EPIRRAGKSGTSTP 1593
+ P+ + P+ E S ++ A TT+S EP KS +TP
Sbjct: 493 TTPKEPAPTTPKEPAPTTTKEPS---PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 549
Query: 1594 TTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPG--TPKSAILVPSEKKVAIIRTPP 1651
P T P + P TP P+ P TP P TPK ++K T P
Sbjct: 550 KEPSPTTTKEPAPTTPKEPAPTTPKKPA-PTTPKEPAPTTPKEPAPTTTKKPAP---TTP 605
Query: 1652 KSPA--TPKQ 1659
K PA TPK+
Sbjct: 606 KEPAPTTPKE 615
Score = 41.6 bits (96), Expect = 0.007
Identities = 83/373 (22%), Positives = 123/373 (32%), Gaps = 35/373 (9%)
Query: 1322 RPSPHDEEEFEVEEAAEAQAEPKDGSPE-----APASPEREEVALSEYKTETYDDYKDET 1376
+ +P +E A PK+ SP AP +P+ + T T
Sbjct: 528 KSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPT 587
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRG 1436
T + T + + T + ET P K L EKP T
Sbjct: 588 TPKEPAPTTTKKPAPTTPKEPAPTTPK-ETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 646
Query: 1437 RIS--TPERKV--AKKEPSTVS----RDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILK 1488
++ TPE +EP+ + ++ A E A T + + K
Sbjct: 647 ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAP 706
Query: 1489 PAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSS--LPR-PS 1545
K T PT L T LAP+ K+ D + K ++ P+ P+
Sbjct: 707 TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766
Query: 1546 SILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTST------PTTPGST 1599
P + + +L ++ ++ E K TST PTTP T
Sbjct: 767 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 826
Query: 1600 AITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKK--VAIIRTP----PKS 1653
A P TP + TP P P TP TP S + P+ K I ++P P+
Sbjct: 827 A--PTTPKEPAPTTPKKPA----PTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPEL 880
Query: 1654 PATPKQLRLINQP 1666
A P L N P
Sbjct: 881 SAEPTPKALENSP 893
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 62.4 bits (150), Expect = 4e-09
Identities = 281/1438 (19%), Positives = 498/1438 (34%), Gaps = 238/1438 (16%)
Query: 111 EKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPS 170
++ + ++Q+ L + P S P +P ++TVT + L F L +
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKSQPTTP--QETVTGK--LFGFGASIFSQASNLIST 948
Query: 171 TAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTL 230
+P QS PG +K A SQP T++ P K Q + + T
Sbjct: 949 AGQPGPHS------QSGPGAPMKQAPAPSQPPTSQG-PPKSTGQAPPAPAKSIPVKKETK 1001
Query: 231 VASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIE-----MPTEAKKDEWGLVAPIS 285
+ E ++ K E + V + K+PP K+ K E +PT+ +K P S
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSP----KPES 1057
Query: 286 PGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFL 345
PL D P + G + T L ++ +
Sbjct: 1058 TCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG 1117
Query: 346 QPDD-KKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVM 404
Q D +K SGP + + P E+ K A PP + ++ + E V
Sbjct: 1118 QLGDIRKMPPAPSGPKAS----PMPVPTESSSQKTA-VPPQVKLVKKQEQEVKTEAEKV- 1171
Query: 405 GKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTI-SDKEAVPKESKPP 463
+LE+ KE ++ E + T T QE EK+ L+EK + +K+ +P+E K
Sbjct: 1172 --ILEKVKETLSMEKIPPMVT-TDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEK-- 1226
Query: 464 KPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTE 523
I++ + E+K P L ++ + E+ D + ++ A +
Sbjct: 1227 ---------IRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHD--LLKSQVQIAEEK 1275
Query: 524 PSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEE-- 581
+ ++QE + K+EG+ + T L P +DK+ T +KE+
Sbjct: 1276 LEGRVAPKTVQE----GKQPQTKMEGLPSGTPQSL--PKEDDKT-------TKTIKEQPQ 1322
Query: 582 -----ATKSIEPGSDYYELSDTRESVHESIDTMSPMHKN--------------------- 615
+EPG + E D + S SP +
Sbjct: 1323 PPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIP 1382
Query: 616 --------GDKEFQTGKESQPSPPAQ----EAGYSTLAQSYPSDLPEEPSSPQERMFTID 663
G K+ +ES PS P+ E+ ++ ++ S L +E S + + +
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVS 1442
Query: 664 PKVYGEKRDLHSKNKD-DLTLSR---SLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFG 719
P+ ++ S ++ ++T+S R ++ ++P S
Sbjct: 1443 PEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS------------ 1490
Query: 720 RGH-DLSPLASDILTNTS--GSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATG 776
+ H + S DI T S++E + + P ++ S +E + E + +G
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG 1550
Query: 777 EE-------------STQAEISCESPFLAKDFYKNGTVMAPDLPEMLD-----LAGTRSR 818
EE A S + F+ + + E AG R
Sbjct: 1551 EEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 819 L---ASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKY 875
L +S S D + RR S E +D P + +L G ++
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDE---DDEAFDESPELKYRETKSQESEELVVTGGGGLRRF 1667
Query: 876 -TVPLPSPVQD---SENLSGESGTFYEG---------TDDKVRRDLATDLSLIEVKLAAA 922
T+ L S + D +E+ ++ +++ TD R S +
Sbjct: 1668 KTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTP 1727
Query: 923 GRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDR-----LDTVLEKS-EEHADSKEH 976
G S E S K G SK Q++KA R L T+ + S EE +E
Sbjct: 1728 GTSPTSVSSLDEDSDSSPSHKKGESK---QQRKARHRPHGPLLPTIEDSSEEEELREEEE 1784
Query: 977 AKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQ 1036
K +E EIE + +++ + E+ + S++ I + P++++ Q
Sbjct: 1785 LLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQ 1844
Query: 1037 GLDFAV--QGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGV 1094
+ + G I + E++ S +P + + M
Sbjct: 1845 AAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQK 1904
Query: 1095 ESGHMKEGTKVSETEVKEKVAK-------PDLVHQEAVDKEESYESSGEHESLTMESLKA 1147
E ++ K +E +E + K P ++ V ++E E ESL
Sbjct: 1905 EGS--QKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVE 1962
Query: 1148 D------EGKKET--SPESSLIQD---EIAVKLSVEIPCPPAVSEADLATDERADVQMEF 1196
D +G T E+ +Q E ++LS +I P + D+Q EF
Sbjct: 1963 DTYNGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDP--------MQKITDLQKEF 2014
Query: 1197 IQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEE---IEAQGEYDKLLFRSD 1253
+ S P I S P IV + S EEE ++A Y++L+ R
Sbjct: 2015 YELESLHS-VVPQEDIVSSSFIIPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQ 2073
Query: 1254 TLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAA 1313
+Q+T G S + E + ES + + + ++ G S + S A
Sbjct: 2074 -MQLTP-GSSPTQAPIGE-------DMTESTMDFDRMPDASLTSSVLSGASLTDSTSSAT 2124
Query: 1314 LEQPEV---ERRPSPHDEEEFEVEEAAEAQ------------AEPKDGSPEAPASPEREE 1358
L P+V + + E+E+ + E Q +EP + + P S
Sbjct: 2125 LSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPS----- 2179
Query: 1359 VALSEYKTETYDDYKDETTIDDSIMDADSLW-VDTQDDDRSIMTEQLETIPKEEKAEK 1415
D T+ S+ DS + T D ++ TE ++ I K E +E+
Sbjct: 2180 ------------DTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEE 2225
Score = 50.4 bits (119), Expect = 2e-05
Identities = 92/430 (21%), Positives = 162/430 (37%), Gaps = 46/430 (10%)
Query: 84 RETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPAS 143
++ +EV +V+ + L E+ DQ ++ A+ P P
Sbjct: 1158 KKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEE 1217
Query: 144 EQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPET 203
++ + EE + + K ++++ T P D+K K S P E+ KH L SQ +
Sbjct: 1218 KKLIPEEEKIRSEEKKPLLEEKKPT-----PEDKKLLPEAKTSAP-EEQKHDLLKSQVQI 1271
Query: 204 TKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQK 263
+ + + T +E G +E + T SL P D K T KEQ
Sbjct: 1272 AEEKLEGRVAPKTVQE-------GKQPQTKMEGLPSGTPQSL--PKED-DKTTKTIKEQP 1321
Query: 264 DWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFT 323
+ P AK D+ + PG +E D D + K + + +
Sbjct: 1322 ----QPPCTAKPDQ------VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGIS 1371
Query: 324 LPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEP----HEAKPDKM 379
L + + I T+ L+ K S Q S P++ D K+E EA+ +
Sbjct: 1372 SSLGEIPSLIPTDEKD----ILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTL 1427
Query: 380 AEAPPSEAMTLPKDAHIPVVEEHVMGKVLEE------EKEAINQETVQQRDTFTPSGQEP 433
A+ SE T P + ++ + L E +E I + +++DTF Q+
Sbjct: 1428 AD-EKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486
Query: 434 ILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQ----TSTEHTFSEQKDQEP 489
I + K+ + K E I+ + P +S E + Q TS + S++ QE
Sbjct: 1487 IPSSKDHKEKSEFVDDITTRRE-PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQED 1545
Query: 490 TTDMLKQDSF 499
+ +++ F
Sbjct: 1546 SQGSGEEEDF 1555
Score = 45.8 bits (107), Expect = 4e-04
Identities = 138/688 (20%), Positives = 251/688 (36%), Gaps = 139/688 (20%)
Query: 109 EQEKEAQHKDQTAALPLAAEETANLPPSPP--PSPASEQTVTVEEDLLTA--SKMEFHDQ 164
+QE+E + + + L +ET ++ PP + ++ +E+D +A K ++
Sbjct: 1159 KQEQEVKTEAEKVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEE 1217
Query: 165 QELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLA 224
++L P + +++K ++ KP + K L+ + +T+ K D+ ++ + A
Sbjct: 1218 KKLIPEEEKIRSEEKKPLLEEKKPTPEDKK--LLPEAKTSAPEEQKHDLLKSQVQIAEEK 1275
Query: 225 LFGHTLVASLEDMKQKTEPSLVVPGI------DLPKEPP----TPKEQKDWFIEMPTEAK 274
L G ++++ KQ P + G+ LPKE T KEQ + P AK
Sbjct: 1276 LEGRVAPKTVQEGKQ---PQTKMEGLPSGTPQSLPKEDDKTTKTIKEQP----QPPCTAK 1328
Query: 275 KDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIV 334
D+ + PG +E D D + K + + + L + + I
Sbjct: 1329 PDQ------VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIP 1382
Query: 335 TETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPH----EAKPDKMAEAPPSEAMTL 390
T+ L+ K S Q S P++ D K+E EA+ +A+ SE T
Sbjct: 1383 TDEKDI----LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEK-SEKKTQ 1437
Query: 391 PKDAHIPVVEEHVMGKVLEE------EKEAINQETVQQRDTFTPSGQEPILTEKETELKL 444
P + ++ + L E +E I + +++DTF Q+ I + K+ + K
Sbjct: 1438 PHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKS 1497
Query: 445 EEKTTISDKEAVPKESKPPKPADEEIGIIQ----TSTEHTFSEQKDQEPTT------DML 494
E I+ + P +S E + Q TS + S++ QE + D +
Sbjct: 1498 EFVDDITTRRE-PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFI 1556
Query: 495 KQDSFPVSLEQAVTDS-------------AMTSKTLEKAMTEPSALIEKSSIQELFEMRV 541
++ +S ++ + S + ++++ +K T+ I + L
Sbjct: 1557 RKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSS 1616
Query: 542 DDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEAT-----------KSIE--- 587
D+ G + E D F D+S KY ET + + E K+IE
Sbjct: 1617 TSIDEDAGRRHSWHDEDDEAF--DESPELKYRETKSQESEELVVTGGGGLRRFKTIELNS 1674
Query: 588 ----------------------PGSDYYELSDTRE---------SVHESIDT-------- 608
P + L+D+ E S+H S T
Sbjct: 1675 TIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSV 1734
Query: 609 --------MSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSD---LPEEPSSPQE 657
SP HK G+ + Q +P P T+ S + EE QE
Sbjct: 1735 SSLDEDSDSSPSHKKGESKQQRKARHRPHGPL----LPTIEDSSEEEELREEEELLKEQE 1790
Query: 658 RMFTIDPKVYGEKRDLHSKNKDDLTLSR 685
+ I+ + K+KD+L R
Sbjct: 1791 KQREIEQQQRKSSSKKSKKDKDELRAQR 1818
Score = 43.5 bits (101), Expect = 0.002
Identities = 162/792 (20%), Positives = 293/792 (36%), Gaps = 121/792 (15%)
Query: 746 LPATTPALEKAPCFPVESK-EEEQIEKVKATGE----ESTQAEISCES--PFLAKDFYKN 798
+P T + + P + K ++Q ++VK E E + +S E P + D +
Sbjct: 1137 MPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQE 1196
Query: 799 GTVMAPD----------LPEMLDLAGTRSRLASVSADAEVARRKSVPSET-VVEDSRTGL 847
+ + D LPE L ++ S + +K P + ++ +++T
Sbjct: 1197 ESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA 1256
Query: 848 PPVTDENHVIVKTDSQL--EDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVR 905
P ++ H ++K+ Q+ E L V K P E L + DDK
Sbjct: 1257 PE--EQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTT 1314
Query: 906 RDLATDLS---LIEVKLAAAGRVKDEFSVDKEASAHISGDKS------------GLSKEF 950
+ + + G+ K E DK ++ KS G+S
Sbjct: 1315 KTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSL 1374
Query: 951 DQEKKA--NDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPT 1008
+ D D +L+ ++ + S+E + + ++E+ L + QA +
Sbjct: 1375 GEIPSLIPTDEKD-ILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQA--------S 1425
Query: 1009 DASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRAT 1068
+ EK+EK + P EV P + +Q ++ L++ IS+ S + R
Sbjct: 1426 TLADEKSEK--KTQPH--EVSPEQPKDQEKTQSLSETLEITISEEEIKES----QEERKD 1477
Query: 1069 ELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKE 1128
K ++ QD+ PSSK +E F+ + + V E+ E P + +V
Sbjct: 1478 TFKKDSQQDI-PSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSS 1536
Query: 1129 ESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVS---EADLA 1185
S DE K+E S S +D I ++ +E+ S + +
Sbjct: 1537 SS-----------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDASGSEDDEFI 1578
Query: 1186 TDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSE--EEEIEAQG 1243
++ ++ KEE+K I+ T + E A + +E+ EA
Sbjct: 1579 RNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 1244 EYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGE 1303
E +L +R Q + EE V T G + TIE + T+ + E
Sbjct: 1639 ESPELKYRETKSQES--------EELVVT----GGGGLRRFKTIELNS-TIADKYSAESS 1685
Query: 1304 SGSHSVRFAALEQPEVERRP---SPHDEEEFEVEEAAEAQAEPKDGSPEAPAS-PEREEV 1359
S+ F E+PE+E SP D E + A + SP + +S E +
Sbjct: 1686 QKKTSLYFD--EEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743
Query: 1360 ALSEYKTETYDDYKDE--------TTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEE 1411
+ S K E+ K TI+DS +++++ E L+ K+
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDS----------SEEEELREEEELLKEQEKQR 1793
Query: 1412 KAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEP-STVSRDEVRRKKAVYKKAEL 1470
+ E++ R+SS +K +K+K + R P+ + P S E R+ A + E
Sbjct: 1794 EIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAA---EMEE 1850
Query: 1471 AKKTEVQAHSPS 1482
++ +SPS
Sbjct: 1851 LHRSSCSEYSPS 1862
Score = 41.6 bits (96), Expect = 0.007
Identities = 81/380 (21%), Positives = 131/380 (34%), Gaps = 75/380 (19%)
Query: 1317 PEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDET 1376
P PS H ++E + + P D P PA P LS K+ T D ++ E
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPD--PGRPAQP-----GLS--KSRTTDTFRSEQ 123
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKP--FKTG 1434
+ RS T L+ E ++R E+H+ F +
Sbjct: 124 KLPG----------------RSPSTISLK--------ESKSRTDLKEEHKSSMMPGFLSE 159
Query: 1435 RGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYT 1494
+S V K P + D ++ KK ++ +K + + I+KP ++
Sbjct: 160 VNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG-----IIKPPLQQQ 214
Query: 1495 RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVS-DGVTKS-----PEKRSSLPRPSSIL 1548
P + P +D + DG KS PEK S P +
Sbjct: 215 PPKPI-----------------PKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTG-- 255
Query: 1549 PPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIR-RAGKSGTSTPTTPGSTAITPGTPP 1607
P +G + + L +S +T +++ +R + K +P+ P TPG PP
Sbjct: 256 KPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 1608 SYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 1667
+ PG P P S + P ++ ++ P + P T K QPL
Sbjct: 316 AQQ------PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---QPL 366
Query: 1668 PDLKNVKSKIGSTDNIKYQP 1687
K + GS QP
Sbjct: 367 GPAKPPAQQTGSEKPSSEQP 386
Score = 33.1 bits (74), Expect = 2.5
Identities = 36/196 (18%), Positives = 78/196 (39%), Gaps = 28/196 (14%)
Query: 28 PPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETA 87
P + D G + +G+ S P + + K++ + E + +
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTD-------EKDILKGLKKDSFSQESSPSSPSDL 1409
Query: 88 EEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTV 147
++ + ++ ++ A+A + + EK+ Q + + P E+T +L +
Sbjct: 1410 AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL------------SE 1457
Query: 148 TVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTY 207
T+E +T S+ E + QE E D +K+S++ +D K + TT+
Sbjct: 1458 TLE---ITISEEEIKESQE------ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRRE 1508
Query: 208 PDKKDMQGTEEEKAPL 223
P + +E E +P+
Sbjct: 1509 PYDSVEESSESENSPV 1524
Score = 32.3 bits (72), Expect = 4.3
Identities = 19/91 (20%), Positives = 33/91 (36%)
Query: 1569 ISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHT 1628
+ SS + ++ P+ S+P ++ P S+ P P + P
Sbjct: 653 VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712
Query: 1629 PGTPKSAILVPSEKKVAIIRTPPKSPATPKQ 1659
G+P + P E PPK P+ P +
Sbjct: 713 HGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 62.4 bits (150), Expect = 4e-09
Identities = 281/1438 (19%), Positives = 498/1438 (34%), Gaps = 238/1438 (16%)
Query: 111 EKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPS 170
++ + ++Q+ L + P S P +P ++TVT + L F L +
Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKSQPTTP--QETVTGK--LFGFGASIFSQASNLIST 948
Query: 171 TAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTL 230
+P QS PG +K A SQP T++ P K Q + + T
Sbjct: 949 AGQPGPHS------QSGPGAPMKQAPAPSQPPTSQG-PPKSTGQAPPAPAKSIPVKKETK 1001
Query: 231 VASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIE-----MPTEAKKDEWGLVAPIS 285
+ E ++ K E + V + K+PP K+ K E +PT+ +K P S
Sbjct: 1002 APAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSP----KPES 1057
Query: 286 PGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFL 345
PL D P + G + T L ++ +
Sbjct: 1058 TCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG 1117
Query: 346 QPDD-KKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVM 404
Q D +K SGP + + P E+ K A PP + ++ + E V
Sbjct: 1118 QLGDIRKMPPAPSGPKAS----PMPVPTESSSQKTA-VPPQVKLVKKQEQEVKTEAEKV- 1171
Query: 405 GKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTI-SDKEAVPKESKPP 463
+LE+ KE ++ E + T T QE EK+ L+EK + +K+ +P+E K
Sbjct: 1172 --ILEKVKETLSMEKIPPMVT-TDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEK-- 1226
Query: 464 KPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTE 523
I++ + E+K P L ++ + E+ D + ++ A +
Sbjct: 1227 ---------IRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHD--LLKSQVQIAEEK 1275
Query: 524 PSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEE-- 581
+ ++QE + K+EG+ + T L P +DK+ T +KE+
Sbjct: 1276 LEGRVAPKTVQE----GKQPQTKMEGLPSGTPQSL--PKEDDKT-------TKTIKEQPQ 1322
Query: 582 -----ATKSIEPGSDYYELSDTRESVHESIDTMSPMHKN--------------------- 615
+EPG + E D + S SP +
Sbjct: 1323 PPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIP 1382
Query: 616 --------GDKEFQTGKESQPSPPAQ----EAGYSTLAQSYPSDLPEEPSSPQERMFTID 663
G K+ +ES PS P+ E+ ++ ++ S L +E S + + +
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVS 1442
Query: 664 PKVYGEKRDLHSKNKD-DLTLSR---SLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFG 719
P+ ++ S ++ ++T+S R ++ ++P S
Sbjct: 1443 PEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS------------ 1490
Query: 720 RGH-DLSPLASDILTNTS--GSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATG 776
+ H + S DI T S++E + + P ++ S +E + E + +G
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG 1550
Query: 777 EE-------------STQAEISCESPFLAKDFYKNGTVMAPDLPEMLD-----LAGTRSR 818
EE A S + F+ + + E AG R
Sbjct: 1551 EEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 819 L---ASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKY 875
L +S S D + RR S E +D P + +L G ++
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDE---DDEAFDESPELKYRETKSQESEELVVTGGGGLRRF 1667
Query: 876 -TVPLPSPVQD---SENLSGESGTFYEG---------TDDKVRRDLATDLSLIEVKLAAA 922
T+ L S + D +E+ ++ +++ TD R S +
Sbjct: 1668 KTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTP 1727
Query: 923 GRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDR-----LDTVLEKS-EEHADSKEH 976
G S E S K G SK Q++KA R L T+ + S EE +E
Sbjct: 1728 GTSPTSVSSLDEDSDSSPSHKKGESK---QQRKARHRPHGPLLPTIEDSSEEEELREEEE 1784
Query: 977 AKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQ 1036
K +E EIE + +++ + E+ + S++ I + P++++ Q
Sbjct: 1785 LLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQ 1844
Query: 1037 GLDFAV--QGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGV 1094
+ + G I + E++ S +P + + M
Sbjct: 1845 AAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQK 1904
Query: 1095 ESGHMKEGTKVSETEVKEKVAK-------PDLVHQEAVDKEESYESSGEHESLTMESLKA 1147
E ++ K +E +E + K P ++ V ++E E ESL
Sbjct: 1905 EGS--QKALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVE 1962
Query: 1148 D------EGKKET--SPESSLIQD---EIAVKLSVEIPCPPAVSEADLATDERADVQMEF 1196
D +G T E+ +Q E ++LS +I P + D+Q EF
Sbjct: 1963 DTYNGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDP--------MQKITDLQKEF 2014
Query: 1197 IQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEE---IEAQGEYDKLLFRSD 1253
+ S P I S P IV + S EEE ++A Y++L+ R
Sbjct: 2015 YELESLHS-VVPQEDIVSSSFIIPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQ 2073
Query: 1254 TLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAA 1313
+Q+T G S + E + ES + + + ++ G S + S A
Sbjct: 2074 -MQLTP-GSSPTQAPIGE-------DMTESTMDFDRMPDASLTSSVLSGASLTDSTSSAT 2124
Query: 1314 LEQPEV---ERRPSPHDEEEFEVEEAAEAQ------------AEPKDGSPEAPASPEREE 1358
L P+V + + E+E+ + E Q +EP + + P S
Sbjct: 2125 LSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPS----- 2179
Query: 1359 VALSEYKTETYDDYKDETTIDDSIMDADSLW-VDTQDDDRSIMTEQLETIPKEEKAEK 1415
D T+ S+ DS + T D ++ TE ++ I K E +E+
Sbjct: 2180 ------------DTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEE 2225
Score = 50.4 bits (119), Expect = 2e-05
Identities = 92/430 (21%), Positives = 162/430 (37%), Gaps = 46/430 (10%)
Query: 84 RETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPAS 143
++ +EV +V+ + L E+ DQ ++ A+ P P
Sbjct: 1158 KKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEE 1217
Query: 144 EQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPET 203
++ + EE + + K ++++ T P D+K K S P E+ KH L SQ +
Sbjct: 1218 KKLIPEEEKIRSEEKKPLLEEKKPT-----PEDKKLLPEAKTSAP-EEQKHDLLKSQVQI 1271
Query: 204 TKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQK 263
+ + + T +E G +E + T SL P D K T KEQ
Sbjct: 1272 AEEKLEGRVAPKTVQE-------GKQPQTKMEGLPSGTPQSL--PKED-DKTTKTIKEQP 1321
Query: 264 DWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFT 323
+ P AK D+ + PG +E D D + K + + +
Sbjct: 1322 ----QPPCTAKPDQ------VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGIS 1371
Query: 324 LPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEP----HEAKPDKM 379
L + + I T+ L+ K S Q S P++ D K+E EA+ +
Sbjct: 1372 SSLGEIPSLIPTDEKD----ILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTL 1427
Query: 380 AEAPPSEAMTLPKDAHIPVVEEHVMGKVLEE------EKEAINQETVQQRDTFTPSGQEP 433
A+ SE T P + ++ + L E +E I + +++DTF Q+
Sbjct: 1428 AD-EKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486
Query: 434 ILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQ----TSTEHTFSEQKDQEP 489
I + K+ + K E I+ + P +S E + Q TS + S++ QE
Sbjct: 1487 IPSSKDHKEKSEFVDDITTRRE-PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQED 1545
Query: 490 TTDMLKQDSF 499
+ +++ F
Sbjct: 1546 SQGSGEEEDF 1555
Score = 45.8 bits (107), Expect = 4e-04
Identities = 138/688 (20%), Positives = 251/688 (36%), Gaps = 139/688 (20%)
Query: 109 EQEKEAQHKDQTAALPLAAEETANLPPSPP--PSPASEQTVTVEEDLLTA--SKMEFHDQ 164
+QE+E + + + L +ET ++ PP + ++ +E+D +A K ++
Sbjct: 1159 KQEQEVKTEAEKVILE-KVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEE 1217
Query: 165 QELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLA 224
++L P + +++K ++ KP + K L+ + +T+ K D+ ++ + A
Sbjct: 1218 KKLIPEEEKIRSEEKKPLLEEKKPTPEDKK--LLPEAKTSAPEEQKHDLLKSQVQIAEEK 1275
Query: 225 LFGHTLVASLEDMKQKTEPSLVVPGI------DLPKEPP----TPKEQKDWFIEMPTEAK 274
L G ++++ KQ P + G+ LPKE T KEQ + P AK
Sbjct: 1276 LEGRVAPKTVQEGKQ---PQTKMEGLPSGTPQSLPKEDDKTTKTIKEQP----QPPCTAK 1328
Query: 275 KDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIV 334
D+ + PG +E D D + K + + + L + + I
Sbjct: 1329 PDQ------VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIP 1382
Query: 335 TETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPH----EAKPDKMAEAPPSEAMTL 390
T+ L+ K S Q S P++ D K+E EA+ +A+ SE T
Sbjct: 1383 TDEKDI----LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEK-SEKKTQ 1437
Query: 391 PKDAHIPVVEEHVMGKVLEE------EKEAINQETVQQRDTFTPSGQEPILTEKETELKL 444
P + ++ + L E +E I + +++DTF Q+ I + K+ + K
Sbjct: 1438 PHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKS 1497
Query: 445 EEKTTISDKEAVPKESKPPKPADEEIGIIQ----TSTEHTFSEQKDQEPTT------DML 494
E I+ + P +S E + Q TS + S++ QE + D +
Sbjct: 1498 EFVDDITTRRE-PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFI 1556
Query: 495 KQDSFPVSLEQAVTDS-------------AMTSKTLEKAMTEPSALIEKSSIQELFEMRV 541
++ +S ++ + S + ++++ +K T+ I + L
Sbjct: 1557 RKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSS 1616
Query: 542 DDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEAT-----------KSIE--- 587
D+ G + E D F D+S KY ET + + E K+IE
Sbjct: 1617 TSIDEDAGRRHSWHDEDDEAF--DESPELKYRETKSQESEELVVTGGGGLRRFKTIELNS 1674
Query: 588 ----------------------PGSDYYELSDTRE---------SVHESIDT-------- 608
P + L+D+ E S+H S T
Sbjct: 1675 TIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSV 1734
Query: 609 --------MSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSD---LPEEPSSPQE 657
SP HK G+ + Q +P P T+ S + EE QE
Sbjct: 1735 SSLDEDSDSSPSHKKGESKQQRKARHRPHGPL----LPTIEDSSEEEELREEEELLKEQE 1790
Query: 658 RMFTIDPKVYGEKRDLHSKNKDDLTLSR 685
+ I+ + K+KD+L R
Sbjct: 1791 KQREIEQQQRKSSSKKSKKDKDELRAQR 1818
Score = 43.5 bits (101), Expect = 0.002
Identities = 162/792 (20%), Positives = 293/792 (36%), Gaps = 121/792 (15%)
Query: 746 LPATTPALEKAPCFPVESK-EEEQIEKVKATGE----ESTQAEISCES--PFLAKDFYKN 798
+P T + + P + K ++Q ++VK E E + +S E P + D +
Sbjct: 1137 MPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQE 1196
Query: 799 GTVMAPD----------LPEMLDLAGTRSRLASVSADAEVARRKSVPSET-VVEDSRTGL 847
+ + D LPE L ++ S + +K P + ++ +++T
Sbjct: 1197 ESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSA 1256
Query: 848 PPVTDENHVIVKTDSQL--EDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGTDDKVR 905
P ++ H ++K+ Q+ E L V K P E L + DDK
Sbjct: 1257 PE--EQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTT 1314
Query: 906 RDLATDLS---LIEVKLAAAGRVKDEFSVDKEASAHISGDKS------------GLSKEF 950
+ + + G+ K E DK ++ KS G+S
Sbjct: 1315 KTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSL 1374
Query: 951 DQEKKA--NDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPT 1008
+ D D +L+ ++ + S+E + + ++E+ L + QA +
Sbjct: 1375 GEIPSLIPTDEKD-ILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQA--------S 1425
Query: 1009 DASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRAT 1068
+ EK+EK + P EV P + +Q ++ L++ IS+ S + R
Sbjct: 1426 TLADEKSEK--KTQPH--EVSPEQPKDQEKTQSLSETLEITISEEEIKES----QEERKD 1477
Query: 1069 ELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKE 1128
K ++ QD+ PSSK +E F+ + + V E+ E P + +V
Sbjct: 1478 TFKKDSQQDI-PSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSS 1536
Query: 1129 ESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVS---EADLA 1185
S DE K+E S S +D I ++ +E+ S + +
Sbjct: 1537 SS-----------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDASGSEDDEFI 1578
Query: 1186 TDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSE--EEEIEAQG 1243
++ ++ KEE+K I+ T + E A + +E+ EA
Sbjct: 1579 RNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 1244 EYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGE 1303
E +L +R Q + EE V T G + TIE + T+ + E
Sbjct: 1639 ESPELKYRETKSQES--------EELVVT----GGGGLRRFKTIELNS-TIADKYSAESS 1685
Query: 1304 SGSHSVRFAALEQPEVERRP---SPHDEEEFEVEEAAEAQAEPKDGSPEAPAS-PEREEV 1359
S+ F E+PE+E SP D E + A + SP + +S E +
Sbjct: 1686 QKKTSLYFD--EEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDS 1743
Query: 1360 ALSEYKTETYDDYKDE--------TTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEE 1411
+ S K E+ K TI+DS +++++ E L+ K+
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDS----------SEEEELREEEELLKEQEKQR 1793
Query: 1412 KAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEP-STVSRDEVRRKKAVYKKAEL 1470
+ E++ R+SS +K +K+K + R P+ + P S E R+ A + E
Sbjct: 1794 EIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAA---EMEE 1850
Query: 1471 AKKTEVQAHSPS 1482
++ +SPS
Sbjct: 1851 LHRSSCSEYSPS 1862
Score = 41.6 bits (96), Expect = 0.007
Identities = 81/380 (21%), Positives = 131/380 (34%), Gaps = 75/380 (19%)
Query: 1317 PEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDET 1376
P PS H ++E + + P D P PA P LS K+ T D ++ E
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPD--PGRPAQP-----GLS--KSRTTDTFRSEQ 123
Query: 1377 TIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKP--FKTG 1434
+ RS T L+ E ++R E+H+ F +
Sbjct: 124 KLPG----------------RSPSTISLK--------ESKSRTDLKEEHKSSMMPGFLSE 159
Query: 1435 RGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYT 1494
+S V K P + D ++ KK ++ +K + + I+KP ++
Sbjct: 160 VNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG-----IIKPPLQQQ 214
Query: 1495 RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVS-DGVTKS-----PEKRSSLPRPSSIL 1548
P + P +D + DG KS PEK S P +
Sbjct: 215 PPKPI-----------------PKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTG-- 255
Query: 1549 PPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIR-RAGKSGTSTPTTPGSTAITPGTPP 1607
P +G + + L +S +T +++ +R + K +P+ P TPG PP
Sbjct: 256 KPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 1608 SYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 1667
+ PG P P S + P ++ ++ P + P T K QPL
Sbjct: 316 AQQ------PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA---QPL 366
Query: 1668 PDLKNVKSKIGSTDNIKYQP 1687
K + GS QP
Sbjct: 367 GPAKPPAQQTGSEKPSSEQP 386
Score = 33.1 bits (74), Expect = 2.5
Identities = 36/196 (18%), Positives = 78/196 (39%), Gaps = 28/196 (14%)
Query: 28 PPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRETA 87
P + D G + +G+ S P + + K++ + E + +
Sbjct: 1357 PQGLSDTGYSSDGISSSLGEIPSLIPTD-------EKDILKGLKKDSFSQESSPSSPSDL 1409
Query: 88 EEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTV 147
++ + ++ ++ A+A + + EK+ Q + + P E+T +L +
Sbjct: 1410 AKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSL------------SE 1457
Query: 148 TVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTY 207
T+E +T S+ E + QE E D +K+S++ +D K + TT+
Sbjct: 1458 TLE---ITISEEEIKESQE------ERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRRE 1508
Query: 208 PDKKDMQGTEEEKAPL 223
P + +E E +P+
Sbjct: 1509 PYDSVEESSESENSPV 1524
Score = 32.3 bits (72), Expect = 4.3
Identities = 19/91 (20%), Positives = 33/91 (36%)
Query: 1569 ISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHT 1628
+ SS + ++ P+ S+P ++ P S+ P P + P
Sbjct: 653 VPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTL 712
Query: 1629 PGTPKSAILVPSEKKVAIIRTPPKSPATPKQ 1659
G+P + P E PPK P+ P +
Sbjct: 713 HGSPSAKAKQPPEADSLSKPAPPKEPSVPSE 743
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 61.6 bits (148), Expect = 7e-09
Identities = 103/474 (21%), Positives = 184/474 (38%), Gaps = 61/474 (12%)
Query: 1063 DDRRATELKLEATQDMTPSSKAPQEADAFMGV------ESGHMKEGTKVSETEVKEKVAK 1116
D++ T L + PS+ +A + + E+ + T+ S + E+ +K
Sbjct: 176 DEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASK 235
Query: 1117 P---DLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEI 1173
+ DKE + E + E T +S EG ET+P+S D +
Sbjct: 236 KLPSQPTTDTSTDKERTSEDMADKEKSTADS--GGEGL-ETAPKSEEFSD---------L 283
Query: 1174 PCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQ 1233
PCP V E T E ++ I K+ +E+ + +D E ++ +E E +
Sbjct: 284 PCP--VEEIKNYTKEHNNL----ILLNKDVQQESSEQKNKSTDKGEKKPDS--NEKGERK 335
Query: 1234 SEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETC--PSE-HKGVIESVVTIEDD 1290
E++E + + ++D DT ++ D A+E+ VE+ PSE + ++V ++D
Sbjct: 336 KEKKE-KTEKKFDHSKKSEDTQKVKD--EKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
Query: 1291 FITV---VQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAE-------AQ 1340
F + V TD S H+ ++ E+ E + EE E+ E +
Sbjct: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
Query: 1341 AEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIM 1400
+ D S S V ++ Y D DE T++ ++ + ++
Sbjct: 453 TQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSI------AKEKEERLL 506
Query: 1401 TEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEV-R 1459
Q+ EEK R+ EK + K GR + E EP EV +
Sbjct: 507 RRQINREKLEEK-----RKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLK 561
Query: 1460 RKKAVYKKAELAKKTEVQA----HSPSRKFILKPAIKYTRPTHLSCVKRKTTAA 1509
+K + KK L+KK + + + +K + K T T C K K +++
Sbjct: 562 ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSS 615
Score = 47.0 bits (110), Expect = 2e-04
Identities = 156/866 (18%), Positives = 314/866 (36%), Gaps = 134/866 (15%)
Query: 835 PSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSP------------ 882
PS V D+ + L +T N + E + + LPS
Sbjct: 193 PSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERT 252
Query: 883 ---VQDSENLSGESGTFYEGTDDKVRRDLATDLSL-IEVKLAAAGRVKDEFSVDKEASAH 938
+ D E + +SG EG + + + +DL +E + ++K+
Sbjct: 253 SEDMADKEKSTADSGG--EGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
Query: 939 ISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKK---TEEAGDEIETFGLGVT 995
S K+ + + +++ +N++ + EK E+ +H+KK T++ DE +
Sbjct: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQA------ 364
Query: 996 YEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQ 1055
++ + L +P++ +S KA+ VE +K+ +D V G D+ +
Sbjct: 365 -KEKEVESLKLPSEKNSNKAK----------TVEGTKEDFSLIDSDVDGLTDITV----- 408
Query: 1056 MASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKE--- 1112
S ++ D + E E T++ +S + +E + E + + TK ++ E
Sbjct: 409 --SSVHTSDLSSFE---EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKT 463
Query: 1113 ------KVAKPDLVHQEAVDKEESYESSGEHESLTMES-----------LKADEGKKETS 1155
V KP L + D ++ +S+ E K +E +K+ +
Sbjct: 464 KSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
Query: 1156 PESSLIQDEIAVKLSVEI------PCPPAVSEADLATDER--ADVQMEFIQGPKEESKET 1207
++ + + + SV++ P + ER + ++ + K++S+
Sbjct: 524 EKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNV 583
Query: 1208 PDISITPSDVAEPLHETIVS----EPAEIQSEEE--EIEAQGEYDKLLFR-SDTLQITDL 1260
+ S E ET+ + E +I S +E + A+ E K R S++L + D
Sbjct: 584 EENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDE 643
Query: 1261 GVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRF-AALEQPEV 1319
+ ++ E EHK + V +E VQ TD + R E+P+
Sbjct: 644 NKNESKLE------REHKRRTSTPVIMEG-----VQEETDTRDVKRQVERSEICTEEPQK 692
Query: 1320 -------ERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALS-EYKTETYDD 1371
E+ D E ++ + + + PE +P +++++ +YK +
Sbjct: 693 QKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHK 752
Query: 1372 YKDETTIDDS--------IMDADSLWVDTQDDDRSIM------TEQLETIPKEEKAEKEA 1417
DET + S + S DD++ +L + K+ K E
Sbjct: 753 TGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEY 812
Query: 1418 RRSSLEKHRKEKPFKTGR--GRISTPERKVAKKEPSTVSRDEVRRKK---AVYKKAELAK 1472
+ E RKE K R + E K + S + +D + K+ + +++E
Sbjct: 813 IIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYS 872
Query: 1473 KTEVQAHSPSRKFILKP-AIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGV 1531
+ + S + LKP + + + + +S K + ++ +G
Sbjct: 873 EDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGA 932
Query: 1532 TKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPI-RRAGKSGT 1590
T K+++ P+P + + + +++ S + T EP+ A S
Sbjct: 933 T----KQATTPKPD------KEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAH 982
Query: 1591 STPTTPGSTAITPGTPPSYSSRTPGT 1616
ST A P Y S T
Sbjct: 983 STQKDSSHRAKLPLAKEKYKSDKDST 1008
Score = 44.7 bits (104), Expect = 8e-04
Identities = 267/1367 (19%), Positives = 476/1367 (34%), Gaps = 186/1367 (13%)
Query: 411 EKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEI 470
+KE +++ + + SG E + ET K EE SD +E K +
Sbjct: 248 DKERTSEDMADKEKSTADSGGEGL----ETAPKSEE---FSDLPCPVEEIKNYTKEHNNL 300
Query: 471 GIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEK 530
++ + SEQK++ K DS + K +K TE K
Sbjct: 301 ILLNKDVQQESSEQKNKSTDKGEKKPDS----------NEKGERKKEKKEKTEKKFDHSK 350
Query: 531 SSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGS 590
S +D K++ A E++ + +K KE+ + S
Sbjct: 351 KS---------EDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLI---DS 398
Query: 591 DYYELSD-TRESVHESIDTMSPMHKNGDKEFQTG---KESQPSPPAQEAGYSTLAQSYPS 646
D L+D T SVH S +S ++ ++E T +E + + +E ++ S
Sbjct: 399 DVDGLTDITVSSVHTS--DLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTS 456
Query: 647 DLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPM 706
D E + + P +Y + +S + D+LT +EQR SI
Sbjct: 457 DSSEGKTKSVRHAYVHKPYLYSK---YYSDSDDELT------------VEQRRQSIAKEK 501
Query: 707 SCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGD-----DYLPATTPALE-KAPCFP 760
+ L R L T S +G D ++T +LE KA
Sbjct: 502 ---EERLLRRQINR-EKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIK 557
Query: 761 VESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLA 820
KE + +EK A ++ + + E K Y+ + E + + +++
Sbjct: 558 EVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCE----KEKIS 613
Query: 821 SVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLP 880
S S + + KS PS+ S + V DEN K +S+LE ++
Sbjct: 614 S-SKELKHVHAKSEPSKPARRLSES--LHVVDEN----KNESKLE-------REHKRRTS 659
Query: 881 SPVQDSENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASA--H 938
+PV E + E+ T V+R + E +K+E + K+ S H
Sbjct: 660 TPVI-MEGVQEETDT------RDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPH 712
Query: 939 ISGDKSGLSKEFDQEKKANDRLDTVLEK--SEEHADSKEHAKKTEEAGDEIETFGL--GV 994
+ KS L KE K+ +R T E S +H + KT GDE E G+
Sbjct: 713 L---KSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKT---GDETELHSSEKGL 766
Query: 995 TYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFG 1054
E+ + K +S +K E+ E K + ++ ++ +V+ +
Sbjct: 767 KVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKEN-- 824
Query: 1055 QMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESG----HMKEGTKVSETEV 1110
N +RR + K +A SS + + D+ + G E + ++
Sbjct: 825 ------NKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
Query: 1111 KEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLS 1170
+L +E V KE+ S E L ++S +GK+ E+ L E A K +
Sbjct: 879 DSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETEL--QEGATKQA 936
Query: 1171 VEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPA 1230
P P + + T+E K+ + D + V EP+ ET S
Sbjct: 937 TT-PKP----DKEKNTEEN--------DSEKQRKSKVEDKPFEETGV-EPVLETASSSAH 982
Query: 1231 EIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEH--KGVIESVVTIE 1288
Q + A+ K ++SD T + + ++ +H K + +
Sbjct: 983 STQKDSSH-RAKLPLAKEKYKSDK-DSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKS 1040
Query: 1289 DDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEE--AAEAQAEPKDG 1346
DD ++ E G+ S+ L + E R +E + EE AA + P
Sbjct: 1041 DDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGS 1100
Query: 1347 SPEAPAS-------PEREEVALSEY----------KTETYDDYKDETTIDDSIMDADSLW 1389
S + P PE+E + + KT+ + + ID M +
Sbjct: 1101 SLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSA 1160
Query: 1390 VDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKE 1449
+D+ R+ + T P + S+ EKH + T + I + K+ E
Sbjct: 1161 TVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGE 1220
Query: 1450 PSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAA 1509
+ R + + + + R + P+ +L + A
Sbjct: 1221 KEPIHRG--------------TTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVA 1266
Query: 1510 GGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSI 1569
G++ L S + +S VT P + S P + R + G S + +S++
Sbjct: 1267 QGDATLEHSTNLDSSPSLS-SVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSAL 1325
Query: 1570 SSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTP 1629
+ + SE + K+ S G T TP S R H P
Sbjct: 1326 PNQSLTVRESEVL----KTSDSKEGGEGFTVDTPAKASITSKR--------------HIP 1367
Query: 1630 GTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQ-PLPDLKNVKSKIGSTDNIKYQPK 1688
++ +L + KV + + + + + L D+ ++ + + N+K K
Sbjct: 1368 EAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIK 1427
Query: 1689 GGQVQIVTKKIDLSHV----TSKCGSLKNIRHRPGGGRVKIESVKLD 1731
I + HV T K ++H+ G+VK S+ ++
Sbjct: 1428 ATVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVE 1474
Score = 42.7 bits (99), Expect = 0.003
Identities = 71/348 (20%), Positives = 124/348 (35%), Gaps = 41/348 (11%)
Query: 1203 ESKETPDISITPSDVAEPLH-ETIVSEPAEIQSEEEEIEAQGEYDKLLFRSD----TLQI 1257
ES +IS D AE + ++ ++P E++ EE + + L D +
Sbjct: 2731 ESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDV 2790
Query: 1258 TDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQP 1317
D + A+ + ET P + K E S +
Sbjct: 2791 LDSRIETAQRQCPETEPHDTK------------------------EENSRDLEELPKTSS 2826
Query: 1318 EVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETT 1377
E S EE+ E + +P+ + S E ++ + + K Y ETT
Sbjct: 2827 ETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETT 2886
Query: 1378 I---DDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTG 1434
+ DDS D + V+ + Q + KE +E RS +EK +
Sbjct: 2887 LKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQE--RSISNDDGEEKIVTSV 2944
Query: 1435 RGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYT 1494
R R P+R + + + S E +R+K+V E K+ E + +P+ T
Sbjct: 2945 RRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEED-EPSGATT 3003
Query: 1495 RPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLP 1542
R T S +R T L+PS+ ++ + T+ ++ P
Sbjct: 3004 RSTTRSEAQRSKT------QLSPSIKRKREVSPPGARTRGQQRVEEAP 3045
Score = 35.4 bits (80), Expect = 0.51
Identities = 84/365 (23%), Positives = 136/365 (37%), Gaps = 55/365 (15%)
Query: 351 KSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKD---AHIPVVEEHVMGKV 407
K L T+ D + E K A++ T PK + +P E +
Sbjct: 235 KKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYT 294
Query: 408 LEEEK-----EAINQETVQQRDTFT------PSGQEPILTEKETELKLEEKTTISDKEAV 456
E + + QE+ +Q++ T P E +KE + K E+K S K
Sbjct: 295 KEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSED 354
Query: 457 PKESKPPKPADE-EIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSK 515
++ K K A E E+ ++ +E ++ K E T K+D SL + D +T
Sbjct: 355 TQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGT----KED---FSLIDSDVD-GLTDI 406
Query: 516 TLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSK-YFE 574
T+ T + SS +E E V D +E G TS + E+K+ +K +
Sbjct: 407 TVSSVHTS-----DLSSFEEDTEEEVVTSDSME-EGEITSDD------EEKNKQNKTKTQ 454
Query: 575 TSALKEEATKSIEPG--------SDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKES 626
TS E TKS+ S YY SD +V + +++ + Q +E
Sbjct: 455 TSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREK 514
Query: 627 QPSPPAQEA-----------GYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHS 675
Q+A G S++ S EP + + + + KV +K L
Sbjct: 515 LEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK 574
Query: 676 KNKDD 680
K K D
Sbjct: 575 KRKKD 579
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 61.2 bits (147), Expect = 9e-09
Identities = 242/1164 (20%), Positives = 407/1164 (34%), Gaps = 236/1164 (20%)
Query: 515 KTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFE 574
+TL++ + S Q + E + + ++K E + ++ P + K F
Sbjct: 241 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 300
Query: 575 TSALK--EEATKSIEPGSDYYELSDTR-ESVHESIDTMSPMHKNGDKEFQTGKE-SQPSP 630
T + T +P D E S+ + E E +DT E T E + P
Sbjct: 301 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 360
Query: 631 PAQEAGYSTLAQSYPS-DLPEEPS------SPQERMFTIDPKVYGEKRDLHSKN------ 677
PA+ A L+ Y +LP E +E+ + +V+ EK ++H +
Sbjct: 361 PAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVH 420
Query: 678 ---------KDDLTLSRSLG------LGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGH 722
+ + + G L A Q + + ++ G + +G
Sbjct: 421 VSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA 480
Query: 723 DLSPLASDILTNTSGSMDE-----GDDYLPATTPALEKAPCFPVESKEEEQIEKVKATG- 776
DLSP + G + E + + L+K K + +K K G
Sbjct: 481 DLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG 540
Query: 777 --EESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSV 834
E ++ +SP ++ + +P+ PE ++ LA V D E +
Sbjct: 541 DEESGEHTQVPADSPDSQEEQKGESSASSPEEPE--EITCLEKGLAEVQQDGEAEEGATS 598
Query: 835 PSETVVEDSRTGLPP-------VTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSE 887
E R G+ P VT + V ++S ED + + L S +
Sbjct: 599 DGEK----KREGVTPWASFKKMVTPKKRVRRPSESDKEDE---LDKVKSATLSSTESTAS 651
Query: 888 NLSGE-SGTFYEGTDDKVRRDLATDLSLIEVKLAAAG--RVKDEFSVDKEASAHISGDKS 944
+ E G+ E ++ +R + T +S + + R + S D+E G
Sbjct: 652 EMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDH 711
Query: 945 GLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDL 1004
+ E ++K+ D +L S+EH D + + E+AG E G GV+ ++ + +
Sbjct: 712 QKADEAGKDKETGT--DGILAGSQEH-DPGQGSSSPEQAGSPTE--GEGVSTWESFKRLV 766
Query: 1005 SIPTDASSEKAEKGLSSVP------EIAEVEPSKKVEQ-GLDFAVQG---------QLDV 1048
+ + S+ EK S+ + EP K+ + + G Q
Sbjct: 767 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQA 826
Query: 1049 KISDFGQMASGLNIDDRRATEL------------KLEATQDMT----PSSKAPQEADAFM 1092
+ D G +G N DD + K+EA Q P KA E +
Sbjct: 827 PVEDAGP--TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 884
Query: 1093 GVESGHMK-----EGTKV--------------SETEVKEKV-AKPDLVHQEAVDKE---- 1128
HM +GT+ S TE E+V A+ L+ +E +++E
Sbjct: 885 SESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAE 944
Query: 1129 -----------ESYESSGE----HESLTMESLKADEGK----KETSPESSLIQD--EIAV 1167
E+ E+ G+ LT E++ A E E E+S ++ E+
Sbjct: 945 EEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVS 1004
Query: 1168 KLSVEIPCPPAVSEA-----------DLATDERADVQMEFIQGPKEESKETPDISIT--P 1214
+S P EA D+ ER E +Q E+ KE + T P
Sbjct: 1005 AVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRT--QEVLQAVAEKVKEESQLPGTGGP 1062
Query: 1215 SDVAEPLHETIVSEPAEIQSEEEEIEAQG---EYDKLLF----RSDTLQITDLGVSGAR- 1266
DV +P+ AE + EE+ EA G E D +L + T T V G
Sbjct: 1063 EDVLQPVQR------AEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTT 1116
Query: 1267 ----------------EEFVETCPSEHKGVIESVVTIEDDFITV--VQTTTDEGESGSHS 1308
E V TC +E ++S + + I V+T TD GS
Sbjct: 1117 PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTP 1176
Query: 1309 VRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREE--------VA 1360
V A + P ++ +E E+ E E + + G EA A P ++E V
Sbjct: 1177 V--ADFDAPGTTQK-----DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVF 1229
Query: 1361 LSEYK-----------------------------TETYDDYKDETTIDDSIMDADSLWVD 1391
E K T+ D Y DE T D + +D
Sbjct: 1230 QEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSID 1289
Query: 1392 TQDD-DRSIMTEQLETIPKEEKAE-KEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKE 1449
T R +TE E+AE K+ L+ H K P R + ER+ + E
Sbjct: 1290 TGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAE 1349
Query: 1450 PSTVSRDEVRRKKAVYKKAELAKK 1473
P+ V+ +++ + AV E++K+
Sbjct: 1350 PTHVNEEKLEHETAVTVSEEVSKQ 1373
Score = 53.9 bits (128), Expect = 1e-06
Identities = 305/1541 (19%), Positives = 533/1541 (34%), Gaps = 300/1541 (19%)
Query: 99 TAEAVAVLKGEQEKEA---QHKDQTAALPLAA-------------EETANLPPSPPP-SP 141
T + + V K E E A HKD + AA EET S SP
Sbjct: 195 TVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISP 254
Query: 142 ASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQS--------------- 186
+E VEE K E ++QE PS + S SE S
Sbjct: 255 PAESGQAVEE-----CKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRK 309
Query: 187 -----KPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKT 241
KP ED A+ + + P+K D + E+ KA +A L AS + Q+
Sbjct: 310 KTSFRKPKEDEVEASEKKKEQE----PEKVDTE--EDGKAEVA--SEKLTASEQAHPQEP 361
Query: 242 EPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDI 301
S P + E +E+P+E + G P EK
Sbjct: 362 AESAHEPRLSAEYEK----------VELPSEEQVS----------GSQGPSEEK------ 395
Query: 302 PKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPAT 361
P+P F ++V + E+V E + K +++T+G
Sbjct: 396 ------------PAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVP 443
Query: 362 AKDSFKIE-EPHEAKPDK----------MAEAPPSEAMTLPKDAHIPVVEEHVMGKV-LE 409
A++ +++ EP EA+P K E P A P + + E V+ +V +
Sbjct: 444 AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEML 503
Query: 410 EEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEE 469
+E + + + FT +G + + +K+ + + VP +S P +E+
Sbjct: 504 SSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADS--PDSQEEQ 561
Query: 470 IGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTD-----SAMTSKTLEKAMTEP 524
G S+ E E ++QD + E A +D +T K M P
Sbjct: 562 KGESSASSPEEPEEITCLEKGLAEVQQDG--EAEEGATSDGEKKREGVTPWASFKKMVTP 619
Query: 525 SALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATK 584
+ + S D +D+++ V +AT + + E + M E EE +
Sbjct: 620 KKRVRRPS-------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVE-EPKPEEPKR 671
Query: 585 SIEPGSDYYEL-----SDTRESVHESIDTM-SPMHKNGD--KEFQTGKESQPSPPAQEAG 636
++ + L S R S D P GD K + GK+ + AG
Sbjct: 672 KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAG 731
Query: 637 YSTLAQSYPSDLPEEPSSPQE-----------RMFTIDPKVYGEKRDLHSKNKDDLTLSR 685
S PE+ SP E R+ T K K L K++D +
Sbjct: 732 SQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKK---SKSKLEEKSEDSIA--- 785
Query: 686 SLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDY 745
G G + + G R A +G+ +E D
Sbjct: 786 --GSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGA-NEDDSD 842
Query: 746 LPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCE--------SPFLAKDFYK 797
+PA P L + E E +Q +K E+ E+S E D +
Sbjct: 843 VPAVVP-LSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTR 901
Query: 798 NGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHV- 856
T++ P + A L V A+A + + + E + E+ + EN
Sbjct: 902 AATIIEERSPSWIS-ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREA 960
Query: 857 ---IVKTDSQL--------EDLGYCVFNKYT-----------VPLPSPVQDSENLSGESG 894
V ++++L E G + T V S + DS + + E+
Sbjct: 961 RGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEAT 1020
Query: 895 TFYE---GTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVD------------KEASA-- 937
E G D ++ T EV A A +VK+E + + A A
Sbjct: 1021 PVQEVEGGVPDIEEQERRTQ----EVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER 1076
Query: 938 -HISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK-------EHAKKTEEAGDEIET 989
+ SGL KE D K +D K+E K E +K + + IE+
Sbjct: 1077 PEEQAEASGLKKETDVVLK----VDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIES 1132
Query: 990 FGLGVTYE---------QALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDF 1040
L T + Q + + +IP D+ P +E + S V DF
Sbjct: 1133 SELVTTCQAETLAGVKSQEMVMEQAIPPDS---------VETPTDSETDGSTPV---ADF 1180
Query: 1041 AVQGQLD----VKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQE--------- 1087
G V+I + ++ASG A + + + PSS QE
Sbjct: 1181 DAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKME 1240
Query: 1088 -----ADAFMGVESGHM---KEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHES 1139
D + VE+ + EGT+ ++ EK D+ E ++ + E
Sbjct: 1241 DTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT--KDVPFFEGLEGSIDTGITVSREK 1298
Query: 1140 LTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATD-ERADVQMEFIQ 1198
+T +LK EG +E + + A++L PP+ E ++ ER + E
Sbjct: 1299 VTEVALKG-EGTEEAE-----CKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTH 1352
Query: 1199 GPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQIT 1258
+E+ + ++++ +V++ L +T V+ P I +E +G L + + + T
Sbjct: 1353 VNEEKLEHETAVTVS-EEVSKQLLQT-VNVPI-IDGAKEVSSLEGSPPPCLGQEEAV-CT 1408
Query: 1259 DLGVSGAREEFVETCPSEHK-------GVIESVVTIE--DDFITVVQTTTDEGES-GSHS 1308
+ V + F T +E + ++E+ T+E + + + ++++ E +H
Sbjct: 1409 KIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHP 1468
Query: 1309 VRFAALEQPEVERRPSP---------HDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEV 1359
A P+ + + +P + E E+ + + + + + V
Sbjct: 1469 GEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSV 1528
Query: 1360 ALSEYKTET---YDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKE 1416
A+ + + E + K + + I A +V T++ ++T +L+T KA+ +
Sbjct: 1529 AIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
Query: 1417 ARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDE 1457
EK +E P+ + P T +++E
Sbjct: 1589 DAGQETEKEGEE------------PQASAQDETPITSAKEE 1617
Score = 50.4 bits (119), Expect = 2e-05
Identities = 140/651 (21%), Positives = 229/651 (35%), Gaps = 98/651 (15%)
Query: 1011 SSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATEL 1070
S E+ E ++ V + + SK+ + + A + + I+D GQ + I+ ++E
Sbjct: 96 SQEEEEVIVTEVGQRDSEDVSKR-DSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSES 154
Query: 1071 KLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEES 1130
LE T S Q D +G + G K T K+K KPD V V K+E
Sbjct: 155 NLEELTQPTES----QAND--IGFKKVFKFVGFKF--TVKKDKTEKPDTVQLLTVKKDEG 206
Query: 1131 YESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLS---VEIPCPPAVSEADLATD 1187
++G + + KE+ P+ S + E +K EI PPA E+ A +
Sbjct: 207 EGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEI-SPPA--ESGQAVE 263
Query: 1188 ERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDK 1247
E + +G +++ KE PS AE + SE + G K
Sbjct: 264 ECKE------EGEEKQEKE-------PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK 310
Query: 1248 LLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSH 1307
FR +E+ VE + + E V T ED V E
Sbjct: 311 TSFRK------------PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQ--- 355
Query: 1308 SVRFAALEQPEVERRPSPHDEEEFE-VEEAAEAQAEPKDGSPEAPASPEREEVALSEYKT 1366
A Q E P E+E VE +E Q G E +P T
Sbjct: 356 -----AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAP---------LAT 401
Query: 1367 ETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLE-TIPKEEKAEKEARRSSLEKH 1425
E +D+ K E ++ + + V+ + +++ E+ ++P EE E +A E
Sbjct: 402 EVFDE-KIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPA 460
Query: 1426 RKEKPFK--------TGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQ 1477
++ K +G +P+ KV K P V + + ++ +VQ
Sbjct: 461 KELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE--------VEMLSSQERMKVQ 512
Query: 1478 AHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEK 1537
SP +K +K LS K+K GG+ A S K
Sbjct: 513 G-SPLKKLFTSTGLK-----KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
Query: 1538 RSSLPRPSSILPPRRGVS-----GDRDENSFSLN-------SSISSSARRTTRSEPIRRA 1585
SS P I +G++ G+ +E + S + +S + T + +RR
Sbjct: 567 ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRP 626
Query: 1586 GKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAI 1636
+S +A T + S G+ P+ P PK +
Sbjct: 627 SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK----PEEPKRKV 673
Score = 40.8 bits (94), Expect = 0.012
Identities = 227/1188 (19%), Positives = 412/1188 (34%), Gaps = 158/1188 (13%)
Query: 358 GPATAKDSFKIEEPHE-----AKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEK 412
G ++ + E+P E A+P+ P +EA A + K+L++
Sbjct: 2 GAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAP-DTTADPAIAASDPATKLLQKNG 60
Query: 413 EAINQETVQQRDTFTP-----SGQEPILT-EKETELKLEEKTTISDKEAVPKESKPPKPA 466
+ V ++D + +GQ+ L + + EE+ +++ E + +
Sbjct: 61 QLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS 120
Query: 467 DEEIGIIQTSTEHTFSEQKDQEPTTDMLKQ-DSFPVSLEQAV--TDSAMTSKTLEKAM-- 521
D+E+ +++ H ++ QE T ++++Q S +LE+ T+S +K
Sbjct: 121 DKEMAT-KSAVVHDITDD-GQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKF 178
Query: 522 -----TEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETS 576
T EK +L ++ D EG GAA + + P SK E
Sbjct: 179 VGFKFTVKKDKTEKPDTVQLLTVKKD-----EGEGAAGAGDHKDPSLGAGEAASKESEPK 233
Query: 577 ALKEEATKSIEPGSDYYELSDTRESVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAG 636
E+ ++++ + E+S ES + + +KE ES SP E G
Sbjct: 234 QSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETG 293
Query: 637 YSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIE 696
ST + + R D EK+ K D +
Sbjct: 294 -STFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTA 352
Query: 697 QRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDY-LPATTPALEK 755
P L + + L S+ SGS ++ P T ++
Sbjct: 353 SEQAHPQEPAESAHEPRLSAEYEKVE----LPSE--EQVSGSQGPSEEKPAPLATEVFDE 406
Query: 756 APCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGT 815
+E +EE + +V + E E E A G+V A +L EM
Sbjct: 407 K----IEVHQEEVVAEVHVSTVEERTEEQKTEVEETA------GSVPAEELVEM------ 450
Query: 816 RSRLASVSADAEVARRKSVPSETVV--EDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFN 873
+ +AE A+ ET V ED G DE + + + ++
Sbjct: 451 ----DAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQ 506
Query: 874 KYTVPLPSPVQD---SENLSGESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFS 930
+ SP++ S L SG +G + + + K E S
Sbjct: 507 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
Query: 931 VDK-EASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADS----------KEHAKK 979
E I+ + GL+ E Q+ +A + + EK E K+ ++
Sbjct: 567 ASSPEEPEEITCLEKGLA-EVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRR 625
Query: 980 TEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLD 1039
E+ E E ++ + LS +SE E+ SV E EP +KV+ +
Sbjct: 626 PSESDKEDEL-------DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVS 678
Query: 1040 F------------AVQGQLDVK------ISDFGQMASGLNIDDRRATELKLEATQDMTP- 1080
+ A +G + + Q A D T+ L +Q+ P
Sbjct: 679 WEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 738
Query: 1081 -SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHES 1139
S +P++A G EG VS E +++ P + +S E +S
Sbjct: 739 QGSSSPEQA--------GSPTEGEGVSTWESFKRLVTP----------RKKSKSKLEEKS 780
Query: 1140 LTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQG 1199
E A G + ++P++ ++E V + I P + E+A V+ G
Sbjct: 781 ---EDSIAGSGVEHSTPDTEPGKEESWVSIKKFI--PGRRKKRPDGKQEQAPVEDAGPTG 835
Query: 1200 PKEESKETPD-ISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQIT 1258
E+ + P + ++ D E E + ++ A+ +E+ E +A E K L S +
Sbjct: 836 ANEDDSDVPAVVPLSEYDAVE--REKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMA 893
Query: 1259 DLGVSGAREEFV--ETCPS-EHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALE 1315
G R + E PS V E + +E + + + + A E
Sbjct: 894 AAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER--------EVIAEE 945
Query: 1316 QPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASP----EREEVALSEYKTETYDD 1371
+P P P + E +EA+ P+ + A P E E + +E TE
Sbjct: 946 EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSA 1005
Query: 1372 YKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEK-- 1429
T D+ +A Q+ + + I ++E+ +E ++ EK ++E
Sbjct: 1006 VSQLTDSPDTTEEA----TPVQEVEGGV-----PDIEEQERRTQEVLQAVAEKVKEESQL 1056
Query: 1430 PFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQ 1477
P G + P ++ + P +E + K+ ++ K + Q
Sbjct: 1057 PGTGGPEDVLQPVQRAEAERP-----EEQAEASGLKKETDVVLKVDAQ 1099
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 61.2 bits (147), Expect = 9e-09
Identities = 242/1164 (20%), Positives = 407/1164 (34%), Gaps = 236/1164 (20%)
Query: 515 KTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFE 574
+TL++ + S Q + E + + ++K E + ++ P + K F
Sbjct: 143 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 202
Query: 575 TSALK--EEATKSIEPGSDYYELSDTR-ESVHESIDTMSPMHKNGDKEFQTGKE-SQPSP 630
T + T +P D E S+ + E E +DT E T E + P
Sbjct: 203 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 262
Query: 631 PAQEAGYSTLAQSYPS-DLPEEPS------SPQERMFTIDPKVYGEKRDLHSKN------ 677
PA+ A L+ Y +LP E +E+ + +V+ EK ++H +
Sbjct: 263 PAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVH 322
Query: 678 ---------KDDLTLSRSLG------LGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGH 722
+ + + G L A Q + + ++ G + +G
Sbjct: 323 VSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA 382
Query: 723 DLSPLASDILTNTSGSMDE-----GDDYLPATTPALEKAPCFPVESKEEEQIEKVKATG- 776
DLSP + G + E + + L+K K + +K K G
Sbjct: 383 DLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG 442
Query: 777 --EESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSV 834
E ++ +SP ++ + +P+ PE ++ LA V D E +
Sbjct: 443 DEESGEHTQVPADSPDSQEEQKGESSASSPEEPE--EITCLEKGLAEVQQDGEAEEGATS 500
Query: 835 PSETVVEDSRTGLPP-------VTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSE 887
E R G+ P VT + V ++S ED + + L S +
Sbjct: 501 DGEK----KREGVTPWASFKKMVTPKKRVRRPSESDKEDE---LDKVKSATLSSTESTAS 553
Query: 888 NLSGE-SGTFYEGTDDKVRRDLATDLSLIEVKLAAAG--RVKDEFSVDKEASAHISGDKS 944
+ E G+ E ++ +R + T +S + + R + S D+E G
Sbjct: 554 EMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDH 613
Query: 945 GLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDL 1004
+ E ++K+ D +L S+EH D + + E+AG E G GV+ ++ + +
Sbjct: 614 QKADEAGKDKETGT--DGILAGSQEH-DPGQGSSSPEQAGSPTE--GEGVSTWESFKRLV 668
Query: 1005 SIPTDASSEKAEKGLSSVP------EIAEVEPSKKVEQ-GLDFAVQG---------QLDV 1048
+ + S+ EK S+ + EP K+ + + G Q
Sbjct: 669 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQA 728
Query: 1049 KISDFGQMASGLNIDDRRATEL------------KLEATQDMT----PSSKAPQEADAFM 1092
+ D G +G N DD + K+EA Q P KA E +
Sbjct: 729 PVEDAGP--TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 786
Query: 1093 GVESGHMK-----EGTKV--------------SETEVKEKV-AKPDLVHQEAVDKE---- 1128
HM +GT+ S TE E+V A+ L+ +E +++E
Sbjct: 787 SESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAE 846
Query: 1129 -----------ESYESSGE----HESLTMESLKADEGK----KETSPESSLIQD--EIAV 1167
E+ E+ G+ LT E++ A E E E+S ++ E+
Sbjct: 847 EEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVS 906
Query: 1168 KLSVEIPCPPAVSEA-----------DLATDERADVQMEFIQGPKEESKETPDISIT--P 1214
+S P EA D+ ER E +Q E+ KE + T P
Sbjct: 907 AVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRT--QEVLQAVAEKVKEESQLPGTGGP 964
Query: 1215 SDVAEPLHETIVSEPAEIQSEEEEIEAQG---EYDKLLF----RSDTLQITDLGVSGAR- 1266
DV +P+ AE + EE+ EA G E D +L + T T V G
Sbjct: 965 EDVLQPVQR------AEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTT 1018
Query: 1267 ----------------EEFVETCPSEHKGVIESVVTIEDDFITV--VQTTTDEGESGSHS 1308
E V TC +E ++S + + I V+T TD GS
Sbjct: 1019 PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTP 1078
Query: 1309 VRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREE--------VA 1360
V A + P ++ +E E+ E E + + G EA A P ++E V
Sbjct: 1079 V--ADFDAPGTTQK-----DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVF 1131
Query: 1361 LSEYK-----------------------------TETYDDYKDETTIDDSIMDADSLWVD 1391
E K T+ D Y DE T D + +D
Sbjct: 1132 QEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSID 1191
Query: 1392 TQDD-DRSIMTEQLETIPKEEKAE-KEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKE 1449
T R +TE E+AE K+ L+ H K P R + ER+ + E
Sbjct: 1192 TGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAE 1251
Query: 1450 PSTVSRDEVRRKKAVYKKAELAKK 1473
P+ V+ +++ + AV E++K+
Sbjct: 1252 PTHVNEEKLEHETAVTVSEEVSKQ 1275
Score = 53.9 bits (128), Expect = 1e-06
Identities = 305/1541 (19%), Positives = 533/1541 (34%), Gaps = 300/1541 (19%)
Query: 99 TAEAVAVLKGEQEKEA---QHKDQTAALPLAA-------------EETANLPPSPPP-SP 141
T + + V K E E A HKD + AA EET S SP
Sbjct: 97 TVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISP 156
Query: 142 ASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQS--------------- 186
+E VEE K E ++QE PS + S SE S
Sbjct: 157 PAESGQAVEE-----CKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRK 211
Query: 187 -----KPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKT 241
KP ED A+ + + P+K D + E+ KA +A L AS + Q+
Sbjct: 212 KTSFRKPKEDEVEASEKKKEQE----PEKVDTE--EDGKAEVA--SEKLTASEQAHPQEP 263
Query: 242 EPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDI 301
S P + E +E+P+E + G P EK
Sbjct: 264 AESAHEPRLSAEYEK----------VELPSEEQVS----------GSQGPSEEK------ 297
Query: 302 PKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPAT 361
P+P F ++V + E+V E + K +++T+G
Sbjct: 298 ------------PAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVP 345
Query: 362 AKDSFKIE-EPHEAKPDK----------MAEAPPSEAMTLPKDAHIPVVEEHVMGKV-LE 409
A++ +++ EP EA+P K E P A P + + E V+ +V +
Sbjct: 346 AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEML 405
Query: 410 EEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEE 469
+E + + + FT +G + + +K+ + + VP +S P +E+
Sbjct: 406 SSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADS--PDSQEEQ 463
Query: 470 IGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTD-----SAMTSKTLEKAMTEP 524
G S+ E E ++QD + E A +D +T K M P
Sbjct: 464 KGESSASSPEEPEEITCLEKGLAEVQQDG--EAEEGATSDGEKKREGVTPWASFKKMVTP 521
Query: 525 SALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATK 584
+ + S D +D+++ V +AT + + E + M E EE +
Sbjct: 522 KKRVRRPS-------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVE-EPKPEEPKR 573
Query: 585 SIEPGSDYYEL-----SDTRESVHESIDTM-SPMHKNGD--KEFQTGKESQPSPPAQEAG 636
++ + L S R S D P GD K + GK+ + AG
Sbjct: 574 KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAG 633
Query: 637 YSTLAQSYPSDLPEEPSSPQE-----------RMFTIDPKVYGEKRDLHSKNKDDLTLSR 685
S PE+ SP E R+ T K K L K++D +
Sbjct: 634 SQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKK---SKSKLEEKSEDSIA--- 687
Query: 686 SLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDY 745
G G + + G R A +G+ +E D
Sbjct: 688 --GSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGA-NEDDSD 744
Query: 746 LPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCE--------SPFLAKDFYK 797
+PA P L + E E +Q +K E+ E+S E D +
Sbjct: 745 VPAVVP-LSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTR 803
Query: 798 NGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVEDSRTGLPPVTDENHV- 856
T++ P + A L V A+A + + + E + E+ + EN
Sbjct: 804 AATIIEERSPSWIS-ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREA 862
Query: 857 ---IVKTDSQL--------EDLGYCVFNKYT-----------VPLPSPVQDSENLSGESG 894
V ++++L E G + T V S + DS + + E+
Sbjct: 863 RGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEAT 922
Query: 895 TFYE---GTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVD------------KEASA-- 937
E G D ++ T EV A A +VK+E + + A A
Sbjct: 923 PVQEVEGGVPDIEEQERRTQ----EVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER 978
Query: 938 -HISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK-------EHAKKTEEAGDEIET 989
+ SGL KE D K +D K+E K E +K + + IE+
Sbjct: 979 PEEQAEASGLKKETDVVLK----VDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIES 1034
Query: 990 FGLGVTYE---------QALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDF 1040
L T + Q + + +IP D+ P +E + S V DF
Sbjct: 1035 SELVTTCQAETLAGVKSQEMVMEQAIPPDS---------VETPTDSETDGSTPV---ADF 1082
Query: 1041 AVQGQLD----VKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQE--------- 1087
G V+I + ++ASG A + + + PSS QE
Sbjct: 1083 DAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKME 1142
Query: 1088 -----ADAFMGVESGHM---KEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHES 1139
D + VE+ + EGT+ ++ EK D+ E ++ + E
Sbjct: 1143 DTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT--KDVPFFEGLEGSIDTGITVSREK 1200
Query: 1140 LTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATD-ERADVQMEFIQ 1198
+T +LK EG +E + + A++L PP+ E ++ ER + E
Sbjct: 1201 VTEVALKG-EGTEEAE-----CKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTH 1254
Query: 1199 GPKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQIT 1258
+E+ + ++++ +V++ L +T V+ P I +E +G L + + + T
Sbjct: 1255 VNEEKLEHETAVTVS-EEVSKQLLQT-VNVPI-IDGAKEVSSLEGSPPPCLGQEEAV-CT 1310
Query: 1259 DLGVSGAREEFVETCPSEHK-------GVIESVVTIE--DDFITVVQTTTDEGES-GSHS 1308
+ V + F T +E + ++E+ T+E + + + ++++ E +H
Sbjct: 1311 KIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHP 1370
Query: 1309 VRFAALEQPEVERRPSP---------HDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEV 1359
A P+ + + +P + E E+ + + + + + V
Sbjct: 1371 GEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSV 1430
Query: 1360 ALSEYKTET---YDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKE 1416
A+ + + E + K + + I A +V T++ ++T +L+T KA+ +
Sbjct: 1431 AIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1490
Query: 1417 ARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDE 1457
EK +E P+ + P T +++E
Sbjct: 1491 DAGQETEKEGEE------------PQASAQDETPITSAKEE 1519
Score = 49.7 bits (117), Expect = 3e-05
Identities = 136/633 (21%), Positives = 219/633 (34%), Gaps = 97/633 (15%)
Query: 1029 EPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEA 1088
E K + + A + + I+D GQ + I+ ++E LE T S Q
Sbjct: 15 EDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTES----QAN 70
Query: 1089 DAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKAD 1148
D +G + G K T K+K KPD V V K+E ++G + +
Sbjct: 71 D--IGFKKVFKFVGFKF--TVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE 126
Query: 1149 EGKKETSPESSLIQDEIAVKLS---VEIPCPPAVSEADLATDERADVQMEFIQGPKEESK 1205
KE+ P+ S + E +K EI PPA E+ A +E + +G +++ K
Sbjct: 127 AASKESEPKQSTEKPEETLKREQSHAEI-SPPA--ESGQAVEECKE------EGEEKQEK 177
Query: 1206 ETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGA 1265
E PS AE + SE + G K FR
Sbjct: 178 E-------PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK------------P 218
Query: 1266 REEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSP 1325
+E+ VE + + E V T ED V E A Q E P
Sbjct: 219 KEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQ--------AHPQEPAESAHEP 270
Query: 1326 HDEEEFE-VEEAAEAQAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMD 1384
E+E VE +E Q G E +P TE +D+ K E ++ + +
Sbjct: 271 RLSAEYEKVELPSEEQVSGSQGPSEEKPAP---------LATEVFDE-KIEVHQEEVVAE 320
Query: 1385 ADSLWVDTQDDDRSIMTEQLE-TIPKEEKAEKEARRSSLEKHRKEKPFK--------TGR 1435
V+ + +++ E+ ++P EE E +A E ++ K +
Sbjct: 321 VHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 380
Query: 1436 GRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTR 1495
G +P+ KV K P V + + ++ +VQ SP +K +K
Sbjct: 381 GADLSPDEKVLSKPPEGVVSE--------VEMLSSQERMKVQG-SPLKKLFTSTGLK--- 428
Query: 1496 PTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVS 1555
LS K+K GG+ A S K SS P I +G++
Sbjct: 429 --KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLA 486
Query: 1556 -----GDRDENSFSLN-------SSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITP 1603
G+ +E + S + +S + T + +RR +S +A
Sbjct: 487 EVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLS 546
Query: 1604 GTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAI 1636
T + S G+ P+ P PK +
Sbjct: 547 STESTASEMQEEMKGSVEEPK----PEEPKRKV 575
Score = 39.3 bits (90), Expect = 0.035
Identities = 105/534 (19%), Positives = 195/534 (36%), Gaps = 84/534 (15%)
Query: 974 KEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKK 1033
K+ ++ E+ E E ++ + LS +SE E+ SV E EP +K
Sbjct: 522 KKRVRRPSESDKEDEL-------DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRK 574
Query: 1034 VEQGLDF------------AVQGQLDVK------ISDFGQMASGLNIDDRRATELKLEAT 1075
V+ + + A +G + + Q A D T+ L +
Sbjct: 575 VDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGS 634
Query: 1076 QDMTP--SSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESYES 1133
Q+ P S +P++A G EG VS E +++ P + +S
Sbjct: 635 QEHDPGQGSSSPEQA--------GSPTEGEGVSTWESFKRLVTP----------RKKSKS 676
Query: 1134 SGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQ 1193
E +S E A G + ++P++ ++E V + I P + E+A V+
Sbjct: 677 KLEEKS---EDSIAGSGVEHSTPDTEPGKEESWVSIKKFI--PGRRKKRPDGKQEQAPVE 731
Query: 1194 MEFIQGPKEESKETPD-ISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRS 1252
G E+ + P + ++ D E E + ++ A+ +E+ E +A E K L S
Sbjct: 732 DAGPTGANEDDSDVPAVVPLSEYDAVE--REKMEAQQAQKSAEQPEQKAATEVSKELSES 789
Query: 1253 DTLQITDLGVSGAREEFV--ETCPS-EHKGVIESVVTIEDDFITVVQTTTDEGESGSHSV 1309
+ G R + E PS V E + +E + + + +
Sbjct: 790 QVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER-------- 841
Query: 1310 RFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASP----EREEVALSEYK 1365
A E+P P P + E +EA+ P+ + A P E E + +E
Sbjct: 842 EVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEET 901
Query: 1366 TETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKH 1425
TE T D+ +A Q+ + + I ++E+ +E ++ EK
Sbjct: 902 TEMVSAVSQLTDSPDTTEEA----TPVQEVEGGV-----PDIEEQERRTQEVLQAVAEKV 952
Query: 1426 RKEK--PFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQ 1477
++E P G + P ++ + P +E + K+ ++ K + Q
Sbjct: 953 KEESQLPGTGGPEDVLQPVQRAEAERP-----EEQAEASGLKKETDVVLKVDAQ 1001
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 60.5 bits (145), Expect = 1e-08
Identities = 187/894 (20%), Positives = 334/894 (37%), Gaps = 144/894 (16%)
Query: 794 DFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARR---KSVPSETVVEDSRTGLPPV 850
DF K DL + + AD+ + + K +PS++V ++S+ P V
Sbjct: 509 DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEV 568
Query: 851 TDENH------------VIVKTDSQLEDLGYCVFNKYTVPL---PSPVQDSENLSGESGT 895
T NH V+VK D ++ + VP PSPV+
Sbjct: 569 TKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVK----------- 617
Query: 896 FYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKK 955
+V ATD ++ K A VK E V E K+ ++EK
Sbjct: 618 ------AEVAEKQATD---VKPKAAKEKTVKKETKVKPE------------DKKEEKEKP 656
Query: 956 ANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKA 1015
+ V +K ++ KE K EE E++ + ++ K++ T K
Sbjct: 657 KKE----VAKKEDKTPIKKEEKPKKEEVKKEVKK-EIKKEEKKEPKKEVKKETPPKEVKK 711
Query: 1016 EKGLSSVPEI--AEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLE 1073
E E+ E EP K++++ A + +S+ + A+ ++ +K +
Sbjct: 712 EVKKEEKKEVKKEEKEPKKEIKKLPKDAKKS--STPLSEAKKPAALKPKVPKKEESVKKD 769
Query: 1074 ATQDMTPSSKAPQEADAFMG--VESGHMKEGTKVSETEVKEKVAKPDLVHQEAVDKEESY 1131
+ P K + G E+ GT + V + + ++ E S
Sbjct: 770 SVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSL 829
Query: 1132 ESSGEHESLTMESLKADE--GKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDER 1189
SS E + E LKA+E K+ P+ LI+DE +K + + EA + ER
Sbjct: 830 MSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPV-------EAYVIQKER 882
Query: 1190 ADVQMEFIQGPKEESKETPDISITPS----------DVAEPLHETIVSEPAEIQSEE--- 1236
E +GP E+PD IT + + EP+ + V + + + E
Sbjct: 883 -----EVTKGP----AESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGF 933
Query: 1237 EEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGV--IESVVTIEDDFITV 1294
EE G+Y++ +++T + + G EE V S+H ES D +I
Sbjct: 934 EESSETGDYEE---KAETEEAEEPEEDG--EEHVCVSASKHSPTEDEESAKAEADAYIRE 988
Query: 1295 VQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASP 1354
+ + G+ + A+E+ E E+ DEE+ + E+A E + EP+ E
Sbjct: 989 KRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEED-KAEDAREEEYEPEKMEAEDYVMA 1047
Query: 1355 EREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTE-QLETIPKEEKA 1413
++ A + E Y + + + Q R + ET+P ++
Sbjct: 1048 VVDKAAEAGGAEEQY-----------GFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096
Query: 1414 EKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKK 1473
E A S E++R+++P + T EP+ + DE+ + V ++
Sbjct: 1097 EATA---SDEENREDQPEEFTATSGYTQSTIEISSEPTPM--DEMSTPRDVMSDETNNEE 1151
Query: 1474 TEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTK 1533
TE SPS++F+ + + + T G S + + KD + T
Sbjct: 1152 TE----SPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTI 1207
Query: 1534 SPEKRSSLPRPSSILPPRRGVSGDRDENSFS---LNSSISSSARRTTRSEPIRRAGKSGT 1590
SP PSS+ +E+ FS L + S + +T + I+ + + +
Sbjct: 1208 SP--------PSSM-----------EEDKFSRSALRDAYCSEVKASTTLD-IKDSISAVS 1247
Query: 1591 STPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKV 1644
S +P + +PPS +TP + ++ TP+ A + P +V
Sbjct: 1248 SEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEV 1301
Score = 57.4 bits (137), Expect = 1e-07
Identities = 266/1280 (20%), Positives = 461/1280 (36%), Gaps = 216/1280 (16%)
Query: 84 RETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQ---TAALPLAAEETANLPPSPPPS 140
R+ ++E + + +V E ++ + EK KD+ T P E+ +P PS
Sbjct: 558 RKESKEETPEVTKVNHVEKPPKVESK-EKVMVKKDKPIKTETKPSVTEK--EVPSKEEPS 614
Query: 141 PASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQ 200
P + V E T K + ++ + T + K++E EK K + + +
Sbjct: 615 PVKAE---VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKK 671
Query: 201 PETTKTYPDKKDMQGT---EEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPP 257
E K KK+++ EE+K P +++K++T P V + ++
Sbjct: 672 EEKPKKEEVKKEVKKEIKKEEKKEPK-----------KEVKKETPPKEVKKEVKKEEKKE 720
Query: 258 TPKEQKDWFIE---MPTEAKKDEWGLVAPISPG---PLTPMREKDVFDD----------- 300
KE+K+ E +P +AKK L P P P +E+ V D
Sbjct: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
Query: 301 ---IPKWEGKQFDSPMPSPFQGGSFTLPLDVM-------KNEIVTETSPFA-PAFLQPD- 348
+ K EGK ++ + G + + E+ E S + P L D
Sbjct: 781 KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840
Query: 349 DKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPV-VEEHVMGKV 407
++ ++ K ++ E E K+ E P EA + K+ + E +
Sbjct: 841 EELKAEEVDVTKDIKPQLELIEDEE----KLKETEPVEAYVIQKEREVTKGPAESPDEGI 896
Query: 408 LEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTISDKE--AVPKESKPPKP 465
E E ++T ++ + G + I ++ EE + D E A +E++ P+
Sbjct: 897 TTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEE 956
Query: 466 ADEEIGIIQTSTEHTFSEQKDQEPTTDML---KQDSFPVSLEQAVTDSAMTSKTLEKAMT 522
EE + S +++ + D K++S ++A D + +EK
Sbjct: 957 DGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDM---DEAIEKGEA 1013
Query: 523 EPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYED--KSGMSKYFETSALKE 580
E S E D++DK E E + ED + + K E +E
Sbjct: 1014 EQS------------EEEADEEDKAEDA-REEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
Query: 581 EATKSIEPGSDYYELSDTRESVHESIDTMSP--MHKNGDKEFQTGKESQPSPPAQEAGY- 637
+ P S RE D P + +E QP +GY
Sbjct: 1061 QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYT 1120
Query: 638 -STLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIE 696
ST+ S +E S+P++ M + E+ + S+ ++T S ++
Sbjct: 1121 QSTIEISSEPTPMDEMSTPRDVM---SDETNNEETESPSQEFVNITKYES-------SLY 1170
Query: 697 QRSMSINLPMSCLDSIALGFNFGR--GHDLSPLASDILTNTSGSMDEGDDYLPATTPALE 754
+ S ++ L+ + G G D + AS I + SM+E D + + AL
Sbjct: 1171 SQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTI--SPPSSMEE-DKF---SRSALR 1224
Query: 755 KAPCFPVESKEEEQI-EKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLA 813
A C V++ I + + A E +SP L+ +P P
Sbjct: 1225 DAYCSEVKASTTLDIKDSISAVSSEKVSPS---KSPSLSP---------SPPSPLEKTPL 1272
Query: 814 GTRSRLAS-------VSADAEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLED 866
G RS S VSA+AEVA ++ VVE+ T E V+ + S
Sbjct: 1273 GERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLE--VVSPSQSVTGS 1330
Query: 867 LGYCVF-----NKYTVPLPSPVQDSENLSGESGTFYEGTDDKVRRDLAT-------DLSL 914
G+ + ++ + LP+ V + S F + D+ R ++ S
Sbjct: 1331 AGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESP 1390
Query: 915 IEVKLA---------AAGRVKDEFSVDKEASAHISG----DKSGLSKEFDQEKKANDRLD 961
IE L+ + + S D +AS + +KSG DQ ++
Sbjct: 1391 IEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTS 1450
Query: 962 TVLEKSEEHADSKEHAKKTEEAGDEIETFGL-GVTYEQALAKDLSIPTDASSEKAEKG-L 1019
T L + ++ S + A E+ G E +T + ++ + ALA D D S + +
Sbjct: 1451 TSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQF 1510
Query: 1020 SSVPE-----IAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEA 1074
S E I+E S K +D +G + S +AS ++ +
Sbjct: 1511 GSFKEDTKMSISEGTVSDKSATPVD---EGVAEDTYSHMEGVAS-VSTASVATSSFPEPT 1566
Query: 1075 TQDMTPSSKA----PQEADAFMGVESGHMKEGTKVSETEV---KEK------VAKPDLVH 1121
T D++PS A P + + ++ T ETE+ KE+ ++ PD
Sbjct: 1567 TDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSP 1626
Query: 1122 QEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAV-- 1179
+ A + + E S+++E + SPE SL D S + P P V
Sbjct: 1627 KTAKSRTPVQDHRSEQSSMSIEF-------GQESPEQSLAMD-----FSRQSPDHPTVGA 1674
Query: 1180 ----------SEADLATDERADVQMEFIQGPKEESKETPD------ISI----------- 1212
+E D + + D + P EE T D IS+
Sbjct: 1675 GVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
Query: 1213 --TPSDVAEPLHETIVSEPA 1230
TPS +A PL E +S+ A
Sbjct: 1735 AHTPSQIASPLQEDTLSDVA 1754
Score = 51.6 bits (122), Expect = 7e-06
Identities = 131/590 (22%), Positives = 217/590 (36%), Gaps = 106/590 (17%)
Query: 98 VTAEAVAVLKGEQEKEAQHKDQTAALPLAA--------EETANLPP----SPPPSPASEQ 145
V V K +Q +++ + AA PL + EET + PP S++
Sbjct: 525 VPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKE 584
Query: 146 TVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTK 205
V V++D ++ + ++ PS EPS K + +EKQ+ D+K A ++ +T K
Sbjct: 585 KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA---TDVKPKA--AKEKTVK 639
Query: 206 TYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDW 265
K EE++ P + K E + + PK+ KE K
Sbjct: 640 KETKVKPEDKKEEKEKP------------KKEVAKKEDKTPIKKEEKPKKEEVKKEVKK- 686
Query: 266 FIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLP 325
E+ E KK+ V +P K+V ++ K E K+ P
Sbjct: 687 --EIKKEEKKEPKKEVKKETP-------PKEVKKEVKKEEKKEVKKEEKEP--------- 728
Query: 326 LDVMKNEIVTETSPFAPAFLQPDDKKS---LQQTSGPATAKDSFKIEEPHEAKPDKMAEA 382
K EI L D KKS L + PA K +E K D +A
Sbjct: 729 ----KKEIKK---------LPKDAKKSSTPLSEAKKPAALKPKVPKKE-ESVKKDSVAAG 774
Query: 383 PPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETEL 442
P E I V+++ GK E A+ +G I KE E
Sbjct: 775 KPKE------KGKIKVIKKE--GKAAEAVAAAVGTGATTAA-VMAAAGIAAIGPAKELE- 824
Query: 443 KLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVS 502
E++ +S E + K+ + K EE+ + + + +D+E + +++ +
Sbjct: 825 --AERSLMSSPEDLTKDFEELKA--EEVDVTK-DIKPQLELIEDEEKLKETEPVEAYVIQ 879
Query: 503 LEQAVTDSAMTSKTLEKAMTEPSALIEKS--SIQELFEMRVDDKDKIEGVGAATSAELDM 560
E+ VT S TE E++ ++ + + VDD +K E GA +
Sbjct: 880 KEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET 939
Query: 561 PFYEDKSGMSKYFE----------TSALKEEAT---KSIEPGSDYYELSDTRESVHESID 607
YE+K+ + E SA K T +S + +D Y + + RESV D
Sbjct: 940 GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAY-IREKRESVASGDD 998
Query: 608 TMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQE 657
++ D+ + G+ Q A E + D EE P++
Sbjct: 999 R---AEEDMDEAIEKGEAEQSEEEADE-------EDKAEDAREEEYEPEK 1038
Score = 33.9 bits (76), Expect = 1.5
Identities = 36/166 (21%), Positives = 65/166 (39%), Gaps = 26/166 (15%)
Query: 81 SADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAAL------PLAAEETANLP 134
SA +T +V + + A A + E E E D+T P ++ + P
Sbjct: 2153 SAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQDRSPSP 2212
Query: 135 PSPPPSPASEQTVTVEEDLLTASKMEFHDQQELT-PSTAEPSDQKEKESEKQSKP----- 188
P S + + +E++L A K + ++ + P T S K+S+ +SKP
Sbjct: 2213 RHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASP 2272
Query: 189 -----GEDLKHAALVSQPETTK---------TYPDKKDMQGTEEEK 220
E + V+ P+ + T P+ K +G E++K
Sbjct: 2273 KPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDK 2318
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 60.5 bits (145), Expect = 1e-08
Identities = 126/546 (23%), Positives = 204/546 (37%), Gaps = 78/546 (14%)
Query: 932 DKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK--EHAKKTEEAGDEIET 989
D E S ++ DK E + + A +R + SE A S+ E ++ E + ET
Sbjct: 1745 DGEGSQRLNRDKDPKLGEAEGDAMAQER-EGKTHNSETSAGSELGEAEQEGEGISERGET 1803
Query: 990 FGLGVTYEQALAKDLSIPTDASSEKAE--KGLSSVPEIAEVEPSKKVEQGLDFAVQGQLD 1047
G G +E L + + D +++ +G+ + E +P +G++ A + + D
Sbjct: 1804 GGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES---EGVE-APEAEGD 1859
Query: 1048 VKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSE 1107
Q A G + E EA + P S+ + +A V+ EG + E
Sbjct: 1860 A------QEAEGEAQPESEDVEAP-EAEGEAQPESEDVETPEAEWEVQPE--SEGAEAPE 1910
Query: 1108 TEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAV 1167
E K A+P+ EA++ E E E A E + +T PES +I+ + A
Sbjct: 1911 AE---KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAE 1967
Query: 1168 K-----------LSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSD 1216
+ L VE+ A EA E DV+ +G +E++E
Sbjct: 1968 EEAQPESEDVEALEVEVETQEAEGEAQ---PESEDVEAPEAEGEMQEAEEE--------- 2015
Query: 1217 VAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSG--AREEFVETCP 1274
A+P + + ++P E +E+E GE K D +D GV A EE E
Sbjct: 2016 -AQPESDGVEAQPKSEGEEAQEVE--GETQKT--EGDAQPESD-GVEAPEAEEEAQEAEG 2069
Query: 1275 SEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVE 1334
+ E+ ED V EGE+ QPE E +P E E +
Sbjct: 2070 EVQEAEGEAHPESED-----VDAQEAEGEA-----------QPESEGVEAPEAEGEAQKA 2113
Query: 1335 EAAEAQAEPKDGSPEAPA--SPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDT 1392
E EA + PE+ +PE E A E + D + E +S ++
Sbjct: 2114 EGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEA-------QPESEGIEA 2166
Query: 1393 QDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRISTPE-RKVAKKEPS 1451
Q+ + E E + E + +E E + + PE + A+ EP
Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
Query: 1452 TVSRDE 1457
V E
Sbjct: 2227 GVETPE 2232
Score = 51.6 bits (122), Expect = 7e-06
Identities = 107/490 (21%), Positives = 193/490 (39%), Gaps = 42/490 (8%)
Query: 884 QDSENLS--GESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKD---EFSVDKEASAH 938
Q+ E +S GE+G G +D ++ + A + A ++ E E+
Sbjct: 1792 QEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV 1851
Query: 939 ISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQ 998
+ + G ++E + E + D ++E A + +T EA E++ G E
Sbjct: 1852 EAPEAEGDAQEAEGEAQPESE-DVEAPEAEGEAQPESEDVETPEAEWEVQPESEGA--EA 1908
Query: 999 ALAKDLSIPTDASSEKAEKGLSSVPEI--AEVEPSKKVEQGLDFAVQGQLDVKISDFGQM 1056
A+ + P S E E PE AE + +++ Q + Q + +V S +
Sbjct: 1909 PEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEE 1968
Query: 1057 ASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAK 1116
+ +D A E+++E TQ+ ++ P+ D G M+E + ++ E A+
Sbjct: 1969 EAQPESEDVEALEVEVE-TQEAEGEAQ-PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ 2026
Query: 1117 PDLVHQEAVDKE---ESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEI 1173
P +EA + E + E + ES +E+ +A+E +E E + E A S ++
Sbjct: 2027 PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE-AHPESEDV 2085
Query: 1174 PCPPAVSEADLATD-------ERADVQMEFIQGPKEESKETPDISITPSDVAE----PLH 1222
A EA ++ E + E I+ P+ E + P+ + AE P
Sbjct: 2086 DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES 2145
Query: 1223 ETIVSEPAE--IQSEEEEIEAQGEYDKLLFRSDTLQITDL-GVSGAREEFVETCPSEHKG 1279
E + ++ AE Q E E IEAQ ++ + ++ + G + E +E +E +
Sbjct: 2146 EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
Query: 1280 VIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEA 1339
E + V+ E E+ +E PE E P E E + E+
Sbjct: 2206 QPE---------LEGVEAPEAEEEAQPEP---EGVETPEAEGEAQPESEGETQGEKKGSP 2253
Query: 1340 QAEPKDGSPE 1349
Q DG E
Sbjct: 2254 QVSLGDGQSE 2263
Score = 45.4 bits (106), Expect = 5e-04
Identities = 117/527 (22%), Positives = 195/527 (37%), Gaps = 65/527 (12%)
Query: 20 TEASAHSHPPEIKDQGGAGEGLV-RSANGFPYREDEEGAFGEHGSQGTYSNTKENGINGE 78
+E SA S E + +G EG+ R G E+ GE + G + +G G
Sbjct: 1779 SETSAGSELGEAEQEG---EGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEG- 1834
Query: 79 LTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPP 138
+ + + E + + V+ AE A E E EAQ + + P AE A
Sbjct: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQ---EAEGEAQPESEDVEAP-EAEGEAQPESEDV 1890
Query: 139 PSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALV 198
+P +E V E + A + E +E P T + + ++ G + + A
Sbjct: 1891 ETPEAEWEVQPESEGAEAPEAE----KEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
Query: 199 SQPETTKTYPDKK--DMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPK-- 254
+Q +T P+ + + Q EEE P + L +E + + E ++ P+
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006
Query: 255 ----------EPPT------PKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVF 298
+P + PK + + E+ E +K E G P S G P E
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE-GDAQPESDGVEAPEAE---- 2061
Query: 299 DDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSG 358
++ + EG+ ++ +G + DV E E P + P+ + Q+ G
Sbjct: 2062 EEAQEAEGEVQEA------EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG 2115
Query: 359 PATAKDSFKIEEPH---EAKPDKMA-EAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEA 414
IE P EA+P+ EAP +E P+ VE + E E
Sbjct: 2116 ---------IEAPETEGEAQPESEGIEAPEAEGEAQPESEG---VEAQDAEGEAQPESEG 2163
Query: 415 INQETVQQRDTFTPSGQEPILTEKETELKLEE-KTTISDKEAVPK-ESKPPKPADEEIGI 472
I + ++ G E E E + + E + ++ EA P+ E A+EE
Sbjct: 2164 IEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP 2223
Query: 473 IQTSTEHTFSE---QKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKT 516
E +E Q + E T K+ S VSL ++ A S +
Sbjct: 2224 EPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSS 2270
Score = 41.2 bits (95), Expect = 0.009
Identities = 64/269 (23%), Positives = 104/269 (38%), Gaps = 37/269 (13%)
Query: 29 PEIKDQGGAGEGLVRSANG--FPYREDEEGAFGEHGSQGTYSNTKENGINGELTSADRET 86
PE +++ EG V+ A G P ED + E +Q + GE A+
Sbjct: 2058 PEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 87 AEEVSARI------VQVVTAEAVAVLKGE----QEKEAQHKDQTAALPL-AAEETANLPP 135
A E ++ AE A + E Q+ E + + ++ + AEE A
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
Query: 136 SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKP-GEDLKH 194
+P +E E + + A + E Q EL E + E E E Q +P G +
Sbjct: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPEL-----EGVEAPEAEEEAQPEPEGVETPE 2232
Query: 195 AALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQKTEPSLVVPGIDLPK 254
A +QPE+ + + QG E++ +P G ++ +E S VP D P
Sbjct: 2233 AEGEAQPES------EGETQG-EKKGSPQVSLGD------GQSEEASESSSPVPE-DRPT 2278
Query: 255 EPPTP----KEQKDWFIEMPTEAKKDEWG 279
PP+P Q+ P+ ++ WG
Sbjct: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWG 2307
Score = 34.7 bits (78), Expect = 0.87
Identities = 61/311 (19%), Positives = 122/311 (39%), Gaps = 30/311 (9%)
Query: 336 ETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPH---EAKPDKM-AEAPPSEAMTLP 391
E P + P+ + Q+ G A +S +E P EA+P+ E P +E P
Sbjct: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQP-ESEDVEAPEAEGEAQPESEDVETPEAEWEVQP 1901
Query: 392 KDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTIS 451
+ E + E EA+ E + ++ QE +E E + + ++ +
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961
Query: 452 DKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSA 511
+ + +E+ +P E++ ++ E T + + +P ++ ++ +++A ++
Sbjct: 1962 ESQEAEEEA---QPESEDVEALEVEVE-TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017
Query: 512 MTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSK 571
S +E +P KS +E E+ + K EG S ++ P E+++
Sbjct: 2018 PESDGVE---AQP-----KSEGEEAQEVE-GETQKTEGDAQPESDGVEAPEAEEEAQ--- 2065
Query: 572 YFETSALKEEATKSIEPGSDYYELSDTR-ESVHESIDTMSP------MHKNGDKEFQTGK 624
E +EA P S+ + + E+ ES +P G + +T
Sbjct: 2066 --EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEG 2123
Query: 625 ESQPSPPAQEA 635
E+QP EA
Sbjct: 2124 EAQPESEGIEA 2134
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 56.2 bits (134), Expect = 3e-07
Identities = 85/379 (22%), Positives = 149/379 (39%), Gaps = 47/379 (12%)
Query: 173 EPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQ-------------GTEEE 219
E + ++KE EK KP E K + P+T ++ P+ KD + E
Sbjct: 1589 ELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648
Query: 220 KAPLAL----FGHTLVASLEDMKQKTEPSLVVPGIDLPKEP-PTPKEQKDWFIEMPTEAK 274
AP AL T+ A L ++ EP+ V EP P P EQ + +++P A
Sbjct: 1649 SAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQ-VDLPPGAD 1707
Query: 275 KDEWGLVAPISPGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLD--VMKNE 332
D+ + P + + D P G F + T PL K+E
Sbjct: 1708 PDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSE 1767
Query: 333 IVTE---TSPFAPAFLQPD-DKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAM 388
E P A A +PD ++K+ A + +++ P AK K ++ S+
Sbjct: 1768 EANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSK-- 1825
Query: 389 TLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKT 448
T + A + +VE+ V K E I++E +++ + +P G+ L E + E + +T
Sbjct: 1826 TPVQAAAVSIVEKPVTRK-----SERIDREKLKRSN--SPRGEAQKLLELKMEAEKITRT 1878
Query: 449 TISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVT 508
+ A + +P P S T + +++ P +++ V
Sbjct: 1879 ASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSP-------------VKEPVE 1925
Query: 509 DSAMTSKTLEKAMTEPSAL 527
+T K LE+ + E +A+
Sbjct: 1926 QPRVTRKRLERELQEAAAV 1944
Score = 43.9 bits (102), Expect = 0.001
Identities = 126/616 (20%), Positives = 221/616 (35%), Gaps = 110/616 (17%)
Query: 112 KEAQHKDQTAALPLAAEETANLPP-SPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPS 170
+EA+ + A P+ E +LPP + P A+ VEE
Sbjct: 1681 EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEE------------------- 1721
Query: 171 TAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTL 230
DQ K PG A PE T P K Q +EE P A
Sbjct: 1722 -GSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDAT 1780
Query: 231 VASLEDMKQKTE--PSLVVPGI-DLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPG 287
+ D QK E P P DL +PP + K P ++K+ + + A
Sbjct: 1781 ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK-----KPNKSKRSKTPVQAAAVSI 1835
Query: 288 PLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETS--------- 338
P+ K + I + + K+ +SP +G + L M+ E +T T+
Sbjct: 1836 VEKPVTRKS--ERIDREKLKRSNSP-----RGEAQKLLELKMEAEKITRTASKNSAADLE 1888
Query: 339 ---PFAP-AFLQPDDKKSLQQTSGPATAKDSFK--IEEPHEAKPDKMAEAPPSEAM-TLP 391
P P + + + +S+ T G + K +E+P + E + A+ T P
Sbjct: 1889 HPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTP 1948
Query: 392 KDAHIPVVEEHVMGKVLEEEKEAINQETVQ-------QRDTFTPSGQEPILTEKETELKL 444
+ P + E KE ET++ R T +G P + + E K+
Sbjct: 1949 RRGRPPKTRRRADEEEENEAKEP--AETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKV 2006
Query: 445 -----EEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQK--DQEPTTDMLKQD 497
E T + + V + S PK A+EE G SEQK ++ TD +
Sbjct: 2007 DATRPEATTEVGPQIGVKESSMEPKAAEEEAG----------SEQKRDRKDAGTDKNPPE 2056
Query: 498 SFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDK-------DKIEGV 550
+ PV + + SK+ ++KS+ + + V + ++ GV
Sbjct: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV 2116
Query: 551 GAATSAELDMPFYEDKSGMSKYFETSAL------KEEATKSIEPGSDYYELSDTRESVHE 604
A + + + P ED G+S ++ + ++E + P + +L+ E + +
Sbjct: 2117 VAVSPEKSESPQKED--GLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQME-LEQ 2173
Query: 605 SIDTMSPM-HKNGDKEFQTGKESQPSP-----PAQEAGYSTLAQSY----------PSDL 648
+++ ++ + + ++ +P PA +A + LA + P +
Sbjct: 2174 AVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENF 2233
Query: 649 PEEPSSPQERMFTIDP 664
P P P E + P
Sbjct: 2234 PAPPPYPGESQTDLQP 2249
Score = 43.5 bits (101), Expect = 0.002
Identities = 107/578 (18%), Positives = 212/578 (36%), Gaps = 131/578 (22%)
Query: 49 PYREDEEGAFGEHGSQGT--YSNTKENGINGELTSADRETAEEVSARIVQ---------- 96
P DE+G H + + Y +++ + + + RE E +S+ + +
Sbjct: 1379 PSDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDK 1438
Query: 97 VVTAEAVAVLKGEQEKEAQHKDQTAALPLAA----------EETANLPPSPPPSPASEQT 146
+T + A+L+ + + ++ + L + +E + P P PS ++
Sbjct: 1439 TITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKK- 1497
Query: 147 VTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKT 206
+ + T S+ + D++E D KE+E E+Q H+++ Q
Sbjct: 1498 ----KKIRTDSEGKMDDKKE---------DHKEEEQERQELFASRFLHSSIFEQDSKRLQ 1544
Query: 207 YPDKKDMQG-------------------TEEEKAPLALFGHTLVASLEDMKQK-----TE 242
+ ++K+ T+ + P+ LF H+ L M+QK +
Sbjct: 1545 HLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLF-HSRFMELTRMQQKEKEKDQK 1603
Query: 243 PSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIP 302
P V D P TP E E K E + P +T + + +
Sbjct: 1604 PKEVEKQEDTENHPKTP--------ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALE 1655
Query: 303 KWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATA 362
K G D + +P +VTE PA + + K + + PA
Sbjct: 1656 KTTG---DKTVEAP----------------LVTEEKTVEPATVSEEAKPASE--PAPAPV 1694
Query: 363 KDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQ 422
+ +++ P A PDK A P+ VEE G ++ ++ +
Sbjct: 1695 EQLEQVDLPPGADPDKEAAMMPAG------------VEEGSSG----DQPPYLDAKPPTP 1738
Query: 423 RDTFTPSGQEPILTEKETELKLEEKTTISDKEAVPKESKPPKPADEEIGIIQTSTEHTFS 482
+F+ + + E ++ L + S++ PK KP AD E + + +
Sbjct: 1739 GASFS-QAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAE----PDANQKAEA 1793
Query: 483 EQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKT---------LEKAMTEPSALIEKSSI 533
+ Q P ++ L+ D PV+ + + + SKT +EK +T S I++ +
Sbjct: 1794 APESQPPASEDLEVDP-PVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKL 1852
Query: 534 ----------QELFEMRVDDKDKIEGVGAATSAELDMP 561
Q+L E++++ + ++A+L+ P
Sbjct: 1853 KRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHP 1890
Score = 36.6 bits (83), Expect = 0.23
Identities = 140/695 (20%), Positives = 250/695 (35%), Gaps = 116/695 (16%)
Query: 942 DKSGLSKEFDQEKKANDRLDTVLEKSEEHADSK--EHAKKTEEAGDEIETFGLGVTYEQA 999
DK KE +QE++ L S DSK +H ++ EE D I G Y +
Sbjct: 1510 DKKEDHKEEEQERQELFA-SRFLHSSIFEQDSKRLQHLERKEEDSDFIS----GRIYGKQ 1564
Query: 1000 LAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASG 1059
++ + TD+ E S E+ ++ +K + V+ Q D + +
Sbjct: 1565 TSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTE----NHPKTP 1620
Query: 1060 LNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETE-----VKEKV 1114
+ + + +ELK TP S P + E T +T +EK
Sbjct: 1621 ESAPENKDSELK-------TPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKT 1673
Query: 1115 AKPDLVHQEAVDKEESYESSGEHESLTMESLK--ADEGKKETSPESSLIQDEIAVK---L 1169
+P V +EA K S + E L L AD K+ + + + + L
Sbjct: 1674 VEPATVSEEA--KPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYL 1731
Query: 1170 SVEIPCPPA-VSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVAEPLHETIVSE 1228
+ P P A S+A+ D D + + P ++S+E + AE T +E
Sbjct: 1732 DAKPPTPGASFSQAESNVDPEPD-STQPLSKPAQKSEEANEPK------AEKPDATADAE 1784
Query: 1229 PAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESVVTIE 1288
P Q E E+Q S+ L++ D V+ ++ P++ K S ++
Sbjct: 1785 PDANQKAEAAPESQPP------ASEDLEV-DPPVAAKDKK-----PNKSK---RSKTPVQ 1829
Query: 1289 DDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSP 1348
+++V+ + +++ +++R SP E + +E EA+ + S
Sbjct: 1830 AAAVSIVEKPVTR--------KSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASK 1881
Query: 1349 EAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIP 1408
+ A E E +L +T + T+ D ++RS + E +E
Sbjct: 1882 NSAADLEHPEPSLPLSRTRRRNVRSVYATMGD-------------HENRSPVKEPVE--- 1925
Query: 1409 KEEKAEKEARRSSLEKHRKEK---PFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVY 1465
+ R LE+ +E P RGR R+ ++E + K
Sbjct: 1926 -----QPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG 1980
Query: 1466 KKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAG-----GESALAPSV- 1519
++ ++KT +K +P + TRP TT G ES++ P
Sbjct: 1981 WRSPRSQKTAAGGGPQGKKGKNEPKVDATRP-------EATTEVGPQIGVKESSMEPKAA 2033
Query: 1520 -----FKQAKDKVSDGVTKSPEKRSSL------PRPSSILPPRRGVSGDRDENSFSLNSS 1568
+Q +D+ G K+P + + + P P +RG R NS +
Sbjct: 2034 EEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG----RSRNS---RLA 2086
Query: 1569 ISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITP 1603
+ SA + G + + G A++P
Sbjct: 2087 VDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSP 2121
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
Length = 2524
Score = 55.1 bits (131), Expect = 6e-07
Identities = 108/565 (19%), Positives = 207/565 (36%), Gaps = 66/565 (11%)
Query: 1225 IVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPSEHKGVIESV 1284
++++P ++ + + + E +K FR +Q G F+E K V E V
Sbjct: 415 LMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKN--FGLIASFLE-----RKTVAECV 467
Query: 1285 VTI-----EDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEA 1339
+ +++ ++V+ + + +Q + +++P P +E + E+ E
Sbjct: 468 LYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEK 527
Query: 1340 QAEPKDGSPEAPASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSI 1399
+AE ++ PE +E L E +T + DE +++ ++Q +
Sbjct: 528 EAEKEEEKPEVEND---KEDLLKEKTDDTSGEDNDEK---EAVASKGRKTANSQGRRKGR 581
Query: 1400 MTEQLETIPKEEKA---EKEARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSRD 1456
+T + E+A ++ A +S+E + R + E + AKK R+
Sbjct: 582 ITRSMANEANSEEAITPQQSAELASMELNESS--------RWTEEEMETAKKGLLEHGRN 633
Query: 1457 EVRRKKAVYKKAELAKKT---EVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGES 1513
+ V K K + + + + +K + + K+K AA E
Sbjct: 634 WSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEE 693
Query: 1514 ALAPSVFKQAKDKVSDGVTKSPEK---RSSLPRPSSILPPRRGVSGDRDENSFSLNSSIS 1570
A P V + + + S GV+ + E+ + S PR SG N+ S SI
Sbjct: 694 AAFPPVVEDEEMEAS-GVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIP 752
Query: 1571 SSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTP------------PSYSSRTPGTPG 1618
S +E + G++G P T G+ PG P P+ +S G P
Sbjct: 753 SP-----HTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPT 807
Query: 1619 TPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPLPDLKNVKSKIG 1678
P P +P P ++ EK+ PP ++ + D + +
Sbjct: 808 PPPAPPSPSAP----PPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVK 863
Query: 1679 S--TDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKIESVKLDFKEKA 1736
S T+ + P G K + + T++ G+LK + G GR ++
Sbjct: 864 SECTEEAEEGPAKG------KDAEAAEATAE-GALKAEKKEGGSGRATTAKSSGAPQDSD 916
Query: 1737 QAKVGSLDNAHHVPGGGNVKIDSQK 1761
+ S D GG ++ S +
Sbjct: 917 SSATCSADEVDEAEGGDKNRLLSPR 941
Score = 37.0 bits (84), Expect = 0.18
Identities = 46/191 (24%), Positives = 72/191 (37%), Gaps = 30/191 (15%)
Query: 106 LKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQ 165
LK E+E+ A+ K + A P AA E A PP VE++ + AS + ++++
Sbjct: 671 LKMEKERNARRKKKKA--PAAASEEAAFPP------------VVEDEEMEASGVSGNEEE 716
Query: 166 ELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPD------KKDMQGTEEE 219
+ + A + E + S P A V+ T++ P K Q +
Sbjct: 717 MVEEAEALHASGNEVPRGECSGP-------ATVNNSSDTESIPSPHTEAAKDTGQNGPKP 769
Query: 220 KAPLALFG---HTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKD 276
A L G ED+ TEP+ P PP P +P E K++
Sbjct: 770 PATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEE 829
Query: 277 EWGLVAPISPG 287
E P+ G
Sbjct: 830 ETAAAPPVEEG 840
Score = 33.1 bits (74), Expect = 2.5
Identities = 67/275 (24%), Positives = 103/275 (37%), Gaps = 32/275 (11%)
Query: 183 EKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKA-PLALFGHTLVAS-----LED 236
+K+ E L+ L + E KK EE A P + + AS E+
Sbjct: 657 KKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEE 716
Query: 237 MKQKTEPSLVVPGIDLPKE----PPTPKEQKDW-FIEMP-TEAKKD--EWGLVAPIS--- 285
M ++ E +L G ++P+ P T D I P TEA KD + G P +
Sbjct: 717 MVEEAE-ALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGA 775
Query: 286 ----PGPLTPMREKDVFDDIPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFA 341
PGP TP E P + +P P P P V K E ET+
Sbjct: 776 DGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAP 835
Query: 342 PAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEE 401
P ++ + + + A D+ K EEP +++ + AE P++ KDA E
Sbjct: 836 PV----EEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKG----KDAE--AAEA 885
Query: 402 HVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILT 436
G + E+KE + + + P + T
Sbjct: 886 TAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSAT 920
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 54.3 bits (129), Expect = 1e-06
Identities = 155/745 (20%), Positives = 284/745 (38%), Gaps = 100/745 (13%)
Query: 328 VMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEA 387
++KN + S L+ ++ K ++T K EE E++ K E P
Sbjct: 213 LLKNSSQQDNSSRESPSLEDEETKKEEETP---------KQEEQKESEKMKSEEQP---- 259
Query: 388 MTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEE- 446
M L + V+EE + K E+EKE + + + + P +E + ++E++ E
Sbjct: 260 MDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENV 319
Query: 447 ---KTTISDKEAVPKESK-------PPKPADEEIG--------IIQTSTEHTFSEQKDQE 488
K + + A PK++K +P E G I + STE T + DQ+
Sbjct: 320 KPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQ 379
Query: 489 PTTDMLKQD-SFPVSLEQAVTDSAMTSKTLEKAMTEPSALIEKSSIQELFEMRVDDKDKI 547
+ K++ + V S T K + E+ + + + + +
Sbjct: 380 AKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGK 439
Query: 548 EGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRESVHESID 607
+ V S E P ++ + +K++ET KEE S P D +++ + ES++
Sbjct: 440 QLVNGEVSDERVAPNFKTEPIETKFYET---KEE---SYSPSKDRNIITEGNGT--ESLN 491
Query: 608 TMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVY 667
++ K G+ E KE+ P ++ S L EEP P E ++D
Sbjct: 492 SVITSMKTGELE----KETAPLRKDADSSISVLEIHSQKAQIEEP-DPPEMETSLDSSEM 546
Query: 668 GEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLP-MSCLDSIALG---FNFGRGHD 723
+DL SK L+ + S + G + P + CL+ + F
Sbjct: 547 A--KDLSSKTA--LSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQR 602
Query: 724 LSPLASDILTNTSGSMDEGDDYLPATTPALEKAP-CFPVES-KEEEQIEKVKATGEESTQ 781
LSP+ ++ +T S G T+P C + S KE + + G +S +
Sbjct: 603 LSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVK 662
Query: 782 AEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSETVVE 841
++ E+ +F K EM +L ++ ++ + + +KS +V
Sbjct: 663 -KVDLETLKEDSEFTK---------VEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVP 712
Query: 842 DSRTGLPPVTDENHVIVKTDSQLEDLGYCV---FNKYTVPLPSPVQDSENLSGESGTFYE 898
+ T T + + ++ Q E + + K P V + EN ++ E
Sbjct: 713 EEET-----TASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEE 767
Query: 899 GTD--------DKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEF 950
T+ ++ R A + + K A R + E V++E++A DK + K+
Sbjct: 768 KTNVGRTLRRSPRISRPTAKVAEIRDQK-ADKKRGEGEDEVEEESTALQKTDKKEILKK- 825
Query: 951 DQEKKANDRLDTVLEKSE-EHADSKEHAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTD 1009
EK N ++ V K + S+ + + DE E G S +
Sbjct: 826 -SEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSG-------------SEKSS 871
Query: 1010 ASSEKAEKGLSSVPEIA-EVEPSKK 1033
A+SE+ E+ S +A + EP KK
Sbjct: 872 AASEEEEEKESEEAILADDDEPCKK 896
Score = 46.2 bits (108), Expect = 3e-04
Identities = 95/447 (21%), Positives = 172/447 (38%), Gaps = 84/447 (18%)
Query: 1097 GHMKEGTKVSETEVKEKVAKPDLVHQEAVD------KEESYESSGEHESLT--------- 1141
GH EG ++ EV ++ P+ E ++ KEESY S + +T
Sbjct: 435 GH--EGKQLVNGEVSDERVAPNF-KTEPIETKFYETKEESYSPSKDRNIITEGNGTESLN 491
Query: 1142 --MESLKADEGKKETSP-----ESSLIQDEI-AVKLSVEIPCPP----AVSEADLATDER 1189
+ S+K E +KET+P +SS+ EI + K +E P PP ++ +++A D
Sbjct: 492 SVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLS 551
Query: 1190 ADVQMEFIQG---------PKEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIE 1240
+ + + PK + + P I + + E +T + + A+ S E
Sbjct: 552 SKTALSSTESCTMKGEEKSPKTKKDKRPPI-LECLEKLEKSKKTFLDKDAQRLSPIPE-- 608
Query: 1241 AQGEYDKLLFRSDTLQITDLGVSGAREEFVETCP--SEHKGVIE--SVVTIEDDFITVVQ 1296
E K S+ + + ++ C + K V+E S T+ + V
Sbjct: 609 ---EVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVD 665
Query: 1297 TTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPER 1356
T + +S V L+ + +EE +E + + + PE
Sbjct: 666 LETLKEDSEFTKVEMDNLDNAQTSG-----------IEEPSETKGSMQKSKFKYKLVPE- 713
Query: 1357 EEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKE 1416
EE SE T + K+ + ++ + ++ + LE K+EK EKE
Sbjct: 714 EETTASENTEITSERQKEGIKL--------TIRISSRKKKPDSPPKVLEPENKQEKTEKE 765
Query: 1417 ARRSSLEKHRKEKPFKTGRGRISTPERKVAKKEPSTVSR------DEVRRKKAVYKKA-- 1468
++++ + + P RIS P KVA+ + DEV + +K
Sbjct: 766 EEKTNVGRTLRRSP------RISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDK 819
Query: 1469 -ELAKKTEVQAHSPSRKFILKPAIKYT 1494
E+ KK+E +S K K +++T
Sbjct: 820 KEILKKSEKDTNSKVSKVKPKGKVRWT 846
Score = 45.4 bits (106), Expect = 5e-04
Identities = 73/403 (18%), Positives = 152/403 (37%), Gaps = 37/403 (9%)
Query: 1100 KEGTKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESL-TMESLKADEGKKETSPES 1158
+E + + E K++ P Q+ +K +S E + E+ T L+ KKE E
Sbjct: 225 RESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEK 284
Query: 1159 SLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGPKEESKETPDISITPSDVA 1218
L++ + VKL +P +E E +D E ++ K E KE P D
Sbjct: 285 ELVKLPVIVKLEKPLP----ENEEKKIIKEESDSFKENVKPIKVEVKE---CRADPKDTK 337
Query: 1219 EPLHETIVSEPAEIQ---------------SEEEEIEAQGEYDKLLFRSDTLQITDLGVS 1263
+ + + EP I+ +EE E + K+ + ++++D S
Sbjct: 338 SSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDS 397
Query: 1264 GAREEFVETCPSEHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVER-R 1322
+ ++ + K ++ + E++ + T T G G V ++ +
Sbjct: 398 PVKGPLCKSV-TPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFK 456
Query: 1323 PSPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALS----EYKTETYDDYKDETTI 1378
P + + +E +E + + ++ ++ E + V S E + ET KD +
Sbjct: 457 TEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADS- 515
Query: 1379 DDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRKEKPFKTGRGRI 1438
S+++ S ++ D M L++ + + SS E T +G
Sbjct: 516 SISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTES-------CTMKGEE 568
Query: 1439 STPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSP 1481
+P+ K K+ P +++ + K + + + + + P
Sbjct: 569 KSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVP 611
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 52.4 bits (124), Expect = 4e-06
Identities = 70/332 (21%), Positives = 128/332 (38%), Gaps = 42/332 (12%)
Query: 165 QELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLA 224
+EL + + + EK EK +KP ++ + E K DK + +E+
Sbjct: 354 KELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEK----- 408
Query: 225 LFGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPI 284
++ LE+ K K + + +L K+ +E+KD E + K E ++
Sbjct: 409 ------ISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELKKISKP 462
Query: 285 SPGPLTPMREKDVFD-DIP-----------KWEGKQFDSPMPSPFQGGSFTLPLDVMKNE 332
P TP K ++ +P + E + P P Q G+ LP E
Sbjct: 463 DLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPTISGHRE 522
Query: 333 IVTE-----TSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMAEAPPSEA 387
+V T F ++ +++ L + F ++ E P + P
Sbjct: 523 LVLSSPEDLTQDFEE--MKREERALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSV 580
Query: 388 MTLPKDAHIPVVEEHVMGKVLEEEKEA-----INQETVQQRDTFTPSGQE-----PILTE 437
L ++ H+ + E+ ++ +V EE+ ET +++DT+ Q P TE
Sbjct: 581 PGLGQEEHV-MKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQREAERLPDRTE 639
Query: 438 KETELKLEEKTTISDKEAVPKESKPPKPADEE 469
E + E K + +K A +E + P+DEE
Sbjct: 640 AREESEPEVKEDVIEK-AELEEMEEVHPSDEE 670
Score = 42.0 bits (97), Expect = 0.005
Identities = 75/334 (22%), Positives = 128/334 (38%), Gaps = 28/334 (8%)
Query: 1309 VRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEAPAS-PEREEVALSEYKTE 1367
+R+ Q ++ P + + ++++ A+++ K + A + +REEV K
Sbjct: 289 LRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEA 348
Query: 1368 TYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKHRK 1427
+ K+ + ++ + + TE E + E++ K + +KH K
Sbjct: 349 RSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKR--KLIKDKVGKKHLK 406
Query: 1428 EKPFKTGRGRISTPERKVAKKEPSTVSRDEVRR-KKAVYKKAELAKKTEVQAHSPSRKFI 1486
EK K + E+K KKE + +DE R+ +K KK E K T+ P K I
Sbjct: 407 EKISKLEEKK--DKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTK-----PELKKI 459
Query: 1487 LKPAIK-YTRPTHLSCVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPS 1545
KP +K +T + K K G + S + + ++S P ++ ++P P+
Sbjct: 460 SKPDLKPFTPEVRKTLYKAKVP---GRVKIDRSRAIRGEKELSSEPQTPPAQKGTVPLPT 516
Query: 1546 SILPPRRGVSGDRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGT 1605
+SG R E S ++ R E A + T P
Sbjct: 517 --------ISGHR-ELVLSSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEEG 567
Query: 1606 PPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVP 1639
PP S+ GTP PS P K LVP
Sbjct: 568 PP--STAIQGTP--PSVPGLGQEEHVMKEKELVP 597
Score = 42.0 bits (97), Expect = 0.005
Identities = 182/863 (21%), Positives = 309/863 (35%), Gaps = 173/863 (20%)
Query: 932 DKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGD------ 985
DK H+ S L ++ D+EKK + L+K E + K+ AKK E+ D
Sbjct: 398 DKVGKKHLKEKISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKDTKPELK 457
Query: 986 -----EIETFGLGVTYEQALAK-DLSIPTDAS-SEKAEKGLSSVPEIAEVEPSKKVEQGL 1038
+++ F V AK + D S + + EK LSS P + P++K L
Sbjct: 458 KISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEP---QTPPAQKGTVPL 514
Query: 1039 DFAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGH 1098
+ G ++ +S + + ++ + E L A Q T P D
Sbjct: 515 P-TISGHRELVLSSPEDLTQ--DFEEMKREERALLAEQRDTGLGDKPFPLDTAEEGPPST 571
Query: 1099 MKEGTKVS-------ETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKADEGK 1151
+GT S E +KEK P+ V +E K+ +S E E + D +
Sbjct: 572 AIQGTPPSVPGLGQEEHVMKEKELVPE-VPEEQGSKDRGLDSGAETEE------EKDTWE 624
Query: 1152 KETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADV-QMEFIQGPKEESKETPDI 1210
++ E+ + D + E P V E + E+A++ +ME + EE ++
Sbjct: 625 EKKQREAERLPDRTEAREESE----PEVKEDVI---EKAELEEMEEVHPSDEEEED---- 673
Query: 1211 SITPSDVAEPLHETIVSEPAEIQSEEEEI---EAQGEYDKLLFRSDTLQITDLGVSGARE 1267
+ AE ++ + EP ++ E G K + +L ++ L
Sbjct: 674 ----ATKAEGFYQKHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGAT 729
Query: 1268 EFVETCPSEH-KGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPH 1326
E V E G E+ TI D+ I DE E RF P P
Sbjct: 730 EHVSYIQDETIPGYSETEQTISDEEI------HDEPEERPAPPRF----HTSTYDLPGPE 779
Query: 1327 DEEEFEVEEAAEAQAEPKD----GSPEAP--------ASPEREEVALSEYKTETYDD--- 1371
FE + A++ G+PE A+P EE +S + T D
Sbjct: 780 GAGPFEASQPADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITECDKLS 839
Query: 1372 -YKDETTIDDSIMD----------ADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRS 1420
+ D S+ SL +DT S TE + + A + S
Sbjct: 840 SFATSVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTS 899
Query: 1421 SLEKHR--KEKPFK----TGR--------GRISTPERKVAKKEPSTVSRDEVRR------ 1460
SLE+ + K P + TG G+ + ER V ++E T + + +
Sbjct: 900 SLEEDKGFKSPPCEDFSVTGESEKRGEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYG 959
Query: 1461 -------KKAVYKKAELAKKTEVQAHSPSRKFIL--------KPAIKYTRPTHLSCVKRK 1505
A++ + E + SP + P+ +T P H S V+ K
Sbjct: 960 TPVFSAPGHALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHT-PFHQSPVEEK 1018
Query: 1506 T-------TAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDR 1558
+ + G++ P V K+ D + V PE+ +L + + PPR S
Sbjct: 1019 SEPQDFQEADSWGDTKRTPGVGKE--DAAEETVKPGPEE-GTLEKEEKVPPPR---SPQA 1072
Query: 1559 DENSFSLNSSISSSARRTTRSEP---IRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPG 1615
E +++ ++ + ++ + ++G T G+ A+ G RT
Sbjct: 1073 QEAPVNIDEGLTGCTIQLLPAQDKAIVFEIMEAGEPTGPILGAEALPGGL------RT-- 1124
Query: 1616 TPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPK--SPATPKQLRLINQPLPDLKN- 1672
P PG P +K ++R P + SP + L +++ P PD N
Sbjct: 1125 ---------LPQEPGKP---------QKDEVLRYPDRSLSPEDAESLSVLSVPSPDTANQ 1166
Query: 1673 ---VKSKIGSTDNIKYQPKGGQV 1692
KS G T+ ++ + +V
Sbjct: 1167 EPTPKSPCGLTEQYLHKDRWPEV 1189
Score = 35.4 bits (80), Expect = 0.51
Identities = 96/423 (22%), Positives = 142/423 (33%), Gaps = 52/423 (12%)
Query: 4 ERKDEA-KAPHWTSAPLTEASAHS-HPPEIKDQGGAGEGLV-----RSANGFPYREDEEG 56
E+KD+A + +W EA + E Q E LV R + E+
Sbjct: 1545 EKKDQALEQKYWALGQKDEALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKV 1604
Query: 57 AFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQH 116
E + TK G+ L R +E Q V E +E +
Sbjct: 1605 KAMEEKLEALLEKTKALGLEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQ 1664
Query: 117 KDQTAALPLAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSD 176
K+ A + E N A EQ T +L K+ F EL A P
Sbjct: 1665 KELAPAWEDTSPEQDNRYWRGREDVALEQD-TYWRELSCERKVWF--PHELDGQGARPHY 1721
Query: 177 QKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAP-----LALFGHTLV 231
+E+ES + +D + L + D KD Q + +K LA L
Sbjct: 1722 TEERESTFLDEGPDDEQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLP 1781
Query: 232 ASLEDMKQKTEPSLVVP--------GIDLPKEP------PTPK---------EQKDWFIE 268
ED ++ ++ P G +P P P PK W +
Sbjct: 1782 PEEEDKLTRSPFEIISPPASPPEMVGQRVPSAPGQESPIPDPKLMPHMKNEPTTPSWLAD 1841
Query: 269 MPTEAKKDEWGLVAPISPGPLTPMREKDVFDDIP-KWEGKQFDSPM------PSPFQGGS 321
+P KD AP+SP P P + P W ++DS + + +GG
Sbjct: 1842 IPPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAAELEGGP 1901
Query: 322 FT-LPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAKPDKMA 380
++ L D K E E A A PD KS + P +K S EP + +P++
Sbjct: 1902 YSPLGKDYRKAEGEREEEGRAEA---PD--KSSHSSKVPEASK-SHATTEPEQTEPEQRE 1955
Query: 381 EAP 383
P
Sbjct: 1956 PTP 1958
Score = 35.0 bits (79), Expect = 0.67
Identities = 145/749 (19%), Positives = 249/749 (33%), Gaps = 112/749 (14%)
Query: 1030 PSKKVEQGLD---------FAVQGQLDVKISDFGQMASGLNIDDRRATELKLEATQDMTP 1080
P K+ +GL+ + V Q D+ I R ++ L+AT
Sbjct: 272 PQNKILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAV 331
Query: 1081 SSKAPQEADAFMGVESGHMKEGTKVSETEVK---------EKVAKPDLVHQEAVDK---- 1127
S A +E G + + ++++TE K EK AKP+ V E+ +
Sbjct: 332 SKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAE 391
Query: 1128 ---------------------EESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIA 1166
EE + + + LK DEG+KE ++ +
Sbjct: 392 KRKLIKDKVGKKHLKEKISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRKD 451
Query: 1167 VKLSVE-------IPCPPAVSEADLATDERADVQME---FIQGPKEESKE--TPDI--SI 1212
K ++ P P V + V+++ I+G KE S E TP
Sbjct: 452 TKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQKGT 511
Query: 1213 TPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDT-----LQITDLGVSGARE 1267
P E ++S P ++ + EE++ + E L + DT D G
Sbjct: 512 VPLPTISGHRELVLSSPEDLTQDFEEMKRE-ERALLAEQRDTGLGDKPFPLDTAEEGPPS 570
Query: 1268 EFVETCPSEHKGV-IESVVTIEDDFITVV---QTTTDEG-ESGSHSVR----FAALEQPE 1318
++ P G+ E V E + + V Q + D G +SG+ + + +Q E
Sbjct: 571 TAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWEEKKQRE 630
Query: 1319 VERRP---SPHDEEEFEVEEAAEAQAEPKDGSPEAPASPEREEVALSE--YKTETYDDYK 1373
ER P +E E EV+E +AE ++ P+ E E+ +E Y+ + K
Sbjct: 631 AERLPDRTEAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEDATKAEGFYQKHMQEPLK 690
Query: 1374 DETTIDDSIMDAD-SLWVDTQDDDRSIMTEQL---------------ETIPKEEKAEKEA 1417
++ + L + + S+ L ETIP + E+
Sbjct: 691 VTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEHVSYIQDETIPGYSETEQTI 750
Query: 1418 RRSSLEKHRKEKP----FKTGRGRISTPE--RKVAKKEPSTVSRDEVRRKKAVYKKAELA 1471
+ +E+P F T + PE +P+ + K + EL
Sbjct: 751 SDEEIHDEPEERPAPPRFHTSTYDLPGPEGAGPFEASQPADSAVPATSGKVYGTPETELT 810
Query: 1472 KKTEVQAHSPSRKFILKPAIKYTRPTHLSCVKRKTTAAGGESAL-APSVFKQAKDK-VSD 1529
T + A + + + A T LS ++L AP + K + D
Sbjct: 811 YPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLD 870
Query: 1530 GVTKSPEKRSSLPRPSSILP------PRRGVSGDRDENSFSLNSSISSSARRTTRSEPIR 1583
VT P R+ + +P P + D+ S S + R E I
Sbjct: 871 TVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPC-EDFSVTGESEKRGEIIG 929
Query: 1584 RAGKSGTSTPTTPGSTA---ITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPS 1640
+ + TA ++ Y + PG +P P G + L P
Sbjct: 930 KGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAPGHALHPGEP-ALGEAEERCLSPD 988
Query: 1641 EKKVAIIRTPPKSPATPKQLRLINQPLPD 1669
+ V + PP P + P+ +
Sbjct: 989 DSTVKMASPPPSGPPSATHTPFHQSPVEE 1017
Score = 31.2 bits (69), Expect = 9.7
Identities = 73/352 (20%), Positives = 130/352 (36%), Gaps = 51/352 (14%)
Query: 125 LAAEETANLPPSPPPSPASEQTVTVEEDLLTASKMEFHDQQELTPSTAEPSDQKEKESE- 183
L + + + P P PA E ED + K +Q++ E QK+K E
Sbjct: 1317 LTPDSSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEH 1376
Query: 184 KQSKPGEDL----KHAALVSQPETTKTYPDKKDMQGTEEEKAPLALFGHTLVASLEDMKQ 239
K+ +D K AL + E K + +G + E+ AL +D
Sbjct: 1377 KEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDL 1436
Query: 240 KTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFD 299
+ + + +P+E EQKD +E +A + P R + +
Sbjct: 1437 EEKDKALEQKDKIPEEKDKALEQKDTALEQKDKA-------LEPKDKDLEQKDRVLEQKE 1489
Query: 300 DIPKWEGKQFDSPMPSPFQGGSFTLPLDV---MKNEIVTETSPFAPAFLQPDDKKSLQQT 356
IP+ + K D + S P D MK+ + +T P+ K Q+
Sbjct: 1490 KIPEEKDKALDQKVRSV----EHKAPEDTVAEMKDRDLEQTDK------APEQKHQAQEQ 1539
Query: 357 SGPATAKDSFKIEEPHEAKPDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAIN 416
+ K +E+ + A K EA+ E+++ + LEE +
Sbjct: 1540 KDKVSEKKDQALEQKYWALGQK------DEAL-----------EQNI--QALEENHQTQE 1580
Query: 417 QETVQQRD-TFTP------SGQEPILTEKETELKLEEKTTISDKEAVPKESK 461
QE++ Q D T P S ++ E++ E LE+ + +E++ +E +
Sbjct: 1581 QESLVQEDKTRKPKMLEEKSPEKVKAMEEKLEALLEKTKALGLEESLVQEGR 1632
Score = 31.2 bits (69), Expect = 9.7
Identities = 97/412 (23%), Positives = 132/412 (32%), Gaps = 73/412 (17%)
Query: 725 SPLASDILTNTSGSMDEGDDYLPATTPALEKAPCFPVESKEEEQIEKVKATGEESTQAEI 784
+PL S++ S ++ EG ATTP + S E ++A +ES + +
Sbjct: 2241 APLLSNLPRPASPALSEGSSS-EATTPV--------ISSVAERFSPSLEAAEQESGELDP 2291
Query: 785 SCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSAD------------AEVARRK 832
E A + T ++P P LDLA + S+ D +E A K
Sbjct: 2292 GMEP---AAHSLWDLTPLSPAPPASLDLA--LAPAPSLPGDMGDGILPCHLECSEAATEK 2346
Query: 833 SVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLS-- 890
P + ED P T N P P+ ++ E +
Sbjct: 2347 PSPFQVPSEDCAANGPTETSPNP--------------------PGPAPAKAENEEAAACP 2386
Query: 891 -GESGTFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISG-------D 942
E G + EG + R D T LS + A G S E A G
Sbjct: 2387 AWERGAWPEGAERSSRPD--TLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEPRPH 2444
Query: 943 KSGLSKEFDQEKKANDRLDTVLEKSEEHADSKEHAKKTEEAGDEIETFGLGVTYEQALAK 1002
+ LS F L+ L S + D + G G G T
Sbjct: 2445 RGELSPSF---------LNPPLPPSIDDRDLSTEEVRLVGRGGRRRVGGPGTTGGPCPVT 2495
Query: 1003 DLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKISDFGQMASGLNI 1062
D + PT AS + + S VP E PS E LD G D D SG +
Sbjct: 2496 DETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDG--DFLPVDKAGGVSGTH- 2552
Query: 1063 DDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKV 1114
R + D PS P D M G E +V KEKV
Sbjct: 2553 HPRPGHDPPPLPQPDPRPS---PPRPDVCMADPEGLSSESGRVERLREKEKV 2601
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,601,352
Number of Sequences: 37866
Number of extensions: 4087461
Number of successful extensions: 24852
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 1053
Number of HSP's that attempted gapping in prelim test: 17434
Number of HSP's gapped (non-prelim): 7176
length of query: 1827
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1710
effective length of database: 13,817,196
effective search space: 23627405160
effective search space used: 23627405160
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.