Search of human proteins with 87116668

Search of human proteins with 87116668

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
         (823 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|87116668 hypothetical protein LOC9870 [Homo sapiens]              1685   0.0  
gi|114520609 neural precursor cell expressed, developmentally do...   221   2e-57
gi|114520607 neural precursor cell expressed, developmentally do...   221   2e-57
gi|222352183 neural precursor cell expressed, developmentally do...   218   2e-56
gi|21361472 neural precursor cell expressed, developmentally dow...   218   2e-56
gi|222352094 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352092 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352090 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352088 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352086 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352084 neural precursor cell expressed, developmentally do...   218   2e-56
gi|222352082 neural precursor cell expressed, developmentally do...   218   2e-56
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]      207   3e-53
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   202   8e-52
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   198   2e-50
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   198   2e-50
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   193   6e-49
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...   187   3e-47
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...   187   3e-47
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]      184   2e-46
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...   183   5e-46
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   182   1e-45
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...   180   4e-45
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              146   7e-35
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]               146   9e-35
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]               146   9e-35
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     128   2e-29
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     128   2e-29
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     128   2e-29
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]        119   9e-27

>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
          Length = 823

 Score = 1685 bits (4363), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSC 60
           MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSC
Sbjct: 1   MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSC 60

Query: 61  KVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQE 120
           KVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQE
Sbjct: 61  KVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQE 120

Query: 121 PNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLT 180
           PNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLT
Sbjct: 121 PNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLT 180

Query: 181 CGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQT 240
           CGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQT
Sbjct: 181 CGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQT 240

Query: 241 FQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAY 300
           FQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAY
Sbjct: 241 FQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAY 300

Query: 301 LYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPK 360
           LYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPK
Sbjct: 301 LYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPK 360

Query: 361 QFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNI 420
           QFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNI
Sbjct: 361 QFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNI 420

Query: 421 LAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATR 480
           LAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATR
Sbjct: 421 LAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATR 480

Query: 481 NFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPN 540
           NFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPN
Sbjct: 481 NFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPN 540

Query: 541 PNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFET 600
           PNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFET
Sbjct: 541 PNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFET 600

Query: 601 DDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYL 660
           DDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYL
Sbjct: 601 DDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYL 660

Query: 661 NLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAV 720
           NLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAV
Sbjct: 661 NLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAV 720

Query: 721 VVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT 780
           VVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT
Sbjct: 721 VVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT 780

Query: 781 HSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823
           HSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML
Sbjct: 781 HSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML 823


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score =  221 bits (563), Expect = 2e-57
 Identities = 141/394 (35%), Positives = 218/394 (55%), Gaps = 25/394 (6%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVV 494
           S  ++ K  FF+R+L++       +K  +K+ R  +LE S +       +D+ K    + 
Sbjct: 519 SRDYKRKYEFFRRKLKK--QNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 576

Query: 495 FQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLKMYE 553
           F  E+ LD+GG  REWF LI K +F+    LF   + +N  L ++PN        L  ++
Sbjct: 577 FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 636

Query: 554 FAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFI 613
           F GR+ G  +Y   L   +       F R F   ++   +     E+ D E+Y S + +I
Sbjct: 637 FIGRVAGMAVYHGKLLDGF-------FIRPFYKMMLHKPITLHDMESVDSEYYNS-LRWI 688

Query: 614 LNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQ 671
           L ND +E++L F   EE + ++ Q     EL  GG++  VTN NK  Y+ L+ Q+R  ++
Sbjct: 689 LENDPTELDLRFIIDEELFGQTHQH----ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNR 744

Query: 672 VKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREK 731
           +++++  F +G  EL+P++L+ IFDENELELLMCG GD+ V+D++ H     G +    +
Sbjct: 745 IQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNG-YSANHQ 803

Query: 732 VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALC-----PSFQIIAAPTHSTLPT 786
           V++WFW  V  +  E+  RLLQF TG+S++P  GFA L       SF +    T   LP 
Sbjct: 804 VIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPR 863

Query: 787 AHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           AHTCFN+L LP Y+S+EE+   LQ+AI E  +GF
Sbjct: 864 AHTCFNRLDLPPYESFEELWDKLQMAI-ENTQGF 896


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score =  221 bits (563), Expect = 2e-57
 Identities = 141/394 (35%), Positives = 218/394 (55%), Gaps = 25/394 (6%)

Query: 436  SETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSK-NFEVV 494
            S  ++ K  FF+R+L++       +K  +K+ R  +LE S +       +D+ K    + 
Sbjct: 866  SRDYKRKYEFFRRKLKK--QNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIE 923

Query: 495  FQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLKMYE 553
            F  E+ LD+GG  REWF LI K +F+    LF   + +N  L ++PN        L  ++
Sbjct: 924  FDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFK 983

Query: 554  FAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFI 613
            F GR+ G  +Y   L   +       F R F   ++   +     E+ D E+Y S + +I
Sbjct: 984  FIGRVAGMAVYHGKLLDGF-------FIRPFYKMMLHKPITLHDMESVDSEYYNS-LRWI 1035

Query: 614  LNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQ 671
            L ND +E++L F   EE + ++ Q     EL  GG++  VTN NK  Y+ L+ Q+R  ++
Sbjct: 1036 LENDPTELDLRFIIDEELFGQTHQH----ELKNGGSEIVVTNKNKKEYIYLVIQWRFVNR 1091

Query: 672  VKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREK 731
            +++++  F +G  EL+P++L+ IFDENELELLMCG GD+ V+D++ H     G +    +
Sbjct: 1092 IQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNG-YSANHQ 1150

Query: 732  VMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALC-----PSFQIIAAPTHSTLPT 786
            V++WFW  V  +  E+  RLLQF TG+S++P  GFA L       SF +    T   LP 
Sbjct: 1151 VIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPR 1210

Query: 787  AHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
            AHTCFN+L LP Y+S+EE+   LQ+AI E  +GF
Sbjct: 1211 AHTCFNRLDLPPYESFEELWDKLQMAI-ENTQGF 1243


>gi|222352183 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 574 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 628

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 629 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 688

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 689 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 740

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 741 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 796

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 797 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 855

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 856 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 915

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 916 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 951


>gi|222352094 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 453 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 507

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 508 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 567

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 568 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 619

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 620 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 675

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 676 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 734

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 830


>gi|222352092 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 453 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 507

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 508 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 567

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 568 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 619

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 620 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 675

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 676 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 734

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 830


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 566 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 620

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 621 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 680

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 681 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 732

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 733 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 788

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 789 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 847

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 848 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 907

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 908 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 943


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 586 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 640

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 641 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 700

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 701 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 752

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 753 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 808

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 809 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 867

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 868 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 927

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 928 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 963


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 594 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 648

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 649 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 708

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 709 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 760

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 761 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 816

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 817 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 875

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 876 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 935

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 936 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 971


>gi|222352084 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850


>gi|222352082 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  218 bits (554), Expect = 2e-56
 Identities = 136/397 (34%), Positives = 223/397 (56%), Gaps = 31/397 (7%)

Query: 436 SETFQDKVNFFQRELRQVHMKRPH---SKVTLKVSRHALLESSLKATRNFSISDWSK-NF 491
           S  F+ K ++F+++L     K+P    ++  +K+ R+ + E S +   +    D  K   
Sbjct: 473 SREFKQKYDYFRKKL-----KKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL 527

Query: 492 EVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPNRPAHLRLK 550
            + F+ E+ LD+GG  REWF L+ K +F+    LF   + +N  L ++PN        L 
Sbjct: 528 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLS 587

Query: 551 MYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKV 610
            + F GR+ G  ++   L   +       F R F   ++G ++     E+ D E+Y S +
Sbjct: 588 YFTFIGRVAGLAVFHGKLLDGF-------FIRPFYKMMLGKQITLNDMESVDSEYYNS-L 639

Query: 611 CFILNNDMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRL 668
            +IL ND +E++L+F   EE + ++ Q+D    L   G++  VTN NK  Y++L+ Q+R 
Sbjct: 640 KWILENDPTELDLMFCIDEENFGQTYQVD----LKPNGSEIMVTNENKREYIDLVIQWRF 695

Query: 669 ASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728
            ++V++++  FL+G  EL+P +L+ IFDENELELLMCG GD+ V+D++ H++   G +  
Sbjct: 696 VNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNG-YCP 754

Query: 729 REKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHST 783
              V++WFW  V  +  E+  RLLQF TG+S++P  GFA L  S     F I    +   
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814

Query: 784 LPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820
           LP AHTCFN+L LP Y+++E++   L +A+ E  +GF
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAV-ENAQGF 850


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score =  207 bits (527), Expect = 3e-53
 Identities = 135/395 (34%), Positives = 210/395 (53%), Gaps = 26/395 (6%)

Query: 439  FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498
            F  K  +F++EL ++        + + V R  + E S +     S  +      +VF+ E
Sbjct: 3994 FDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGE 4053

Query: 499  EALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFA 555
            E  D GG  REW+ +I + +F+    LF R S  ++     NP+    P HL    ++F 
Sbjct: 4054 EGQDAGGLLREWYMIISREMFNPMYALF-RTSPGDRVTYTINPSSHCNPNHL--SYFKFV 4110

Query: 556  GRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN 615
            GR+V K +Y++ L   Y       FTRSF   I+G  + Y   E++D  FY+  V ++L 
Sbjct: 4111 GRIVAKAVYDNRLLECY-------FTRSFYKHILGKSVRYTDMESEDYHFYQGLV-YLLE 4162

Query: 616  NDMSEM--ELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVK 673
            ND+S +  +L F+ E       + +V +L   GA   VT  NK  Y++L+ Q R+   ++
Sbjct: 4163 NDVSTLGYDLTFSTEVQEFG--VCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIR 4220

Query: 674  EEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM 733
            +++  FL+G  E++P+ L++IF E ELELL+ G   I + D K++       +      +
Sbjct: 4221 KQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY--HKYQSNSIQI 4278

Query: 734  RWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAAL-----CPSFQIIAAP-THSTLPTA 787
            +WFW  + S  Q + A+ LQF TG+S++P  GFAAL        FQI     +   LP+A
Sbjct: 4279 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSA 4338

Query: 788  HTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
            HTCFNQL LP Y+S+E++  ML LAI E  EGFG+
Sbjct: 4339 HTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4373


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
           sapiens]
          Length = 862

 Score =  202 bits (515), Expect = 8e-52
 Identities = 137/392 (34%), Positives = 206/392 (52%), Gaps = 27/392 (6%)

Query: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDE 498
           F+ KV +F+   +Q+ M + H K+T  V+R  L E S +   +FS  D  +   V+F  E
Sbjct: 487 FKAKVQYFRFWCQQLAMPQ-HIKIT--VTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGE 543

Query: 499 EALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFA 555
           E LD+GG  REWF L+   + +    LF     +N  L   NP     P HL  K + F 
Sbjct: 544 EGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCL-QINPASYINPDHL--KYFRFI 600

Query: 556 GRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILN 615
           GR +   L+         + +   F+  F  +I+   +  K  E+ DPEFY S +    N
Sbjct: 601 GRFIAMALFHG-------KFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN 653

Query: 616 N-DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKE 674
           N +  ++E+ F+ +K    G++ K  +L   G    VT  NK  Y+ ++A++RL+  V+E
Sbjct: 654 NIEECDLEMYFSVDK-EILGEI-KSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEE 711

Query: 675 EVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMR 734
           + + F +G NE++P+  L  FD  ELE+L+CG  +I ++D++ HA+     +    K + 
Sbjct: 712 QTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIY--RHYARTSKQIM 769

Query: 735 WFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHT 789
           WFW  V  +  E+  RLLQF TG+ +LP GGFA L  S     F I      + LP +HT
Sbjct: 770 WFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHT 829

Query: 790 CFNQLCLPTYDSYEEVHRMLQLAISEGCEGFG 821
           CFN+L LP Y SYE++   L  AI E  EGFG
Sbjct: 830 CFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 860


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  198 bits (503), Expect = 2e-50
 Identities = 136/379 (35%), Positives = 189/379 (49%), Gaps = 28/379 (7%)

Query: 454 HMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFEL 513
           H     S V + VSR  L E S +   N    D  +   ++ + EE LD+GG  REWF L
Sbjct: 68  HSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL 127

Query: 514 ICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGA 571
           +   + +    LF     NN  L ++P  +  P HL    + F GR +   LY       
Sbjct: 128 LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTY--FRFIGRFIAMALYHG----- 180

Query: 572 YKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEK 629
             + +   FT  F  +++  R   K  E+ DPEFY S + +I  N++ E  +EL F ++ 
Sbjct: 181 --KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNS-IVWIKENNLEECGLELYFIQDM 237

Query: 630 YNKSGQLDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELV 687
                 L KV   EL  GG    VT  NK  Y+ LL  +R    V+E+ + FL G NE+ 
Sbjct: 238 EI----LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVA 293

Query: 688 PENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEE 747
           P   L  FDE ELEL++CG  +I +SD++   +     +    K ++WFW VV  +  E+
Sbjct: 294 PLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIY--RHYTKNSKQIQWFWQVVKEMDNEK 351

Query: 748 LARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSY 802
             RLLQF TG+ +LP GGFA L  S     F I      + LP +HTCFN+L LP Y SY
Sbjct: 352 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 411

Query: 803 EEVHRMLQLAISEGCEGFG 821
           E++   L  AI E  EGFG
Sbjct: 412 EQLREKLLYAIEE-TEGFG 429


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
           isoform 1 [Homo sapiens]
          Length = 870

 Score =  198 bits (503), Expect = 2e-50
 Identities = 136/379 (35%), Positives = 189/379 (49%), Gaps = 28/379 (7%)

Query: 454 HMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFEL 513
           H     S V + VSR  L E S +   N    D  +   ++ + EE LD+GG  REWF L
Sbjct: 507 HSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL 566

Query: 514 ICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGA 571
           +   + +    LF     NN  L ++P  +  P HL    + F GR +   LY       
Sbjct: 567 LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTY--FRFIGRFIAMALYHG----- 619

Query: 572 YKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEK 629
             + +   FT  F  +++  R   K  E+ DPEFY S + +I  N++ E  +EL F ++ 
Sbjct: 620 --KFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNS-IVWIKENNLEECGLELYFIQDM 676

Query: 630 YNKSGQLDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELV 687
                 L KV   EL  GG    VT  NK  Y+ LL  +R    V+E+ + FL G NE+ 
Sbjct: 677 EI----LGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVA 732

Query: 688 PENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEE 747
           P   L  FDE ELEL++CG  +I +SD++   +     +    K ++WFW VV  +  E+
Sbjct: 733 PLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIY--RHYTKNSKQIQWFWQVVKEMDNEK 790

Query: 748 LARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSY 802
             RLLQF TG+ +LP GGFA L  S     F I      + LP +HTCFN+L LP Y SY
Sbjct: 791 RIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSY 850

Query: 803 EEVHRMLQLAISEGCEGFG 821
           E++   L  AI E  EGFG
Sbjct: 851 EQLREKLLYAIEE-TEGFG 868


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  193 bits (490), Expect = 6e-49
 Identities = 139/423 (32%), Positives = 221/423 (52%), Gaps = 39/423 (9%)

Query: 420 ILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVT---------LKVSRHA 470
           +L    + S   +I  ++ F+D+  +F   L   H  +P S +          L V R +
Sbjct: 505 LLECPELMSRFMHIIKAQPFKDRCEWFYEHL---HSGQPDSDMVHRPVNENDILLVHRDS 561

Query: 471 LLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFS 530
           +  SS +     + +   +   V F  EE +  G  R EWF+++   + +    LFT+ +
Sbjct: 562 IFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVR-EWFDILSNEIVNPDYALFTQSA 620

Query: 531 DNNQALVHPNPN---RPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQ 587
           D       PN N    P HL    + FAG+++G  L        ++QLV   FTRSF   
Sbjct: 621 DGTT--FQPNSNSYVNPDHLNY--FRFAGQILGLALN-------HRQLVNIYFTRSFYKH 669

Query: 588 IIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEM--ELVFAEEKYNKSGQLDKVVELMTG 645
           I+G+ ++Y+   + DPE+ K+ + +IL+ND+S++  EL F+ E  +  G +++V  L  G
Sbjct: 670 ILGIPVNYQDVASIDPEYAKN-LQWILDNDISDLGLELTFSVET-DVFGAMEEV-PLKPG 726

Query: 646 GAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMC 705
           G    VT  NK  Y+ L+ + R+   ++ ++  FL+G +  +P +L+ +FDE ELELL+ 
Sbjct: 727 GGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLS 786

Query: 706 GTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGG 765
           G  +I VSD+  +     G +   + V++WFW VV  +TQEE   LLQF TGSS++P GG
Sbjct: 787 GMPEIDVSDWIKNTEYTSG-YEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGG 845

Query: 766 FAAL-----CPSFQIIAAP-THSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEG 819
           FA +       +F I A P T + LPT+ TC N L LP Y S E +   L +A+  G  G
Sbjct: 846 FANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYG 905

Query: 820 FGM 822
           + M
Sbjct: 906 YTM 908


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
           sapiens]
          Length = 757

 Score =  187 bits (476), Expect = 3e-47
 Identities = 133/400 (33%), Positives = 204/400 (51%), Gaps = 43/400 (10%)

Query: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
           K+   + EL     +  H ++  +VSR  + E S +        D  K   V F+ EE L
Sbjct: 381 KLKVLRHELSLQQPQAGHCRI--EVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGL 438

Query: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
           D+GG  REW  L+C  + +    LF ++S +N  ++  NP+    P HL    + F GR+
Sbjct: 439 DYGGVAREWLYLLCHEMLNPYYGLF-QYSTDNIYMLQINPDSSINPDHL--SYFHFVGRI 495

Query: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
           +G  ++     G Y   +   FT  F  Q++G  +     E+ DPE +KS V +IL ND+
Sbjct: 496 MGLAVFH----GHY---INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV-WILENDI 547

Query: 619 SE-MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVE 677
           +  ++  F  E +N  G++ +  EL   G   PVT  NK  Y+ L   +R    ++ +  
Sbjct: 548 TPVLDHTFCVE-HNAFGRILQH-ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFL 605

Query: 678 HFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKA-----HAVVVGGSWHFREKV 732
              KG NEL+P++LL  FD+ ELEL++ G   I ++D+K+     H V           +
Sbjct: 606 ALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVA-------DSNI 658

Query: 733 MRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS----------FQIIAAPTHS 782
           +RWFW  V +  +E  ARLLQF TGS+++P  GF AL  S            +I A T  
Sbjct: 659 VRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANT-D 717

Query: 783 TLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
            LP AHTCFN++ +P Y+SYE+++  L  A+ E C GF +
Sbjct: 718 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC-GFAV 756


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
           sapiens]
          Length = 731

 Score =  187 bits (476), Expect = 3e-47
 Identities = 133/400 (33%), Positives = 204/400 (51%), Gaps = 43/400 (10%)

Query: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
           K+   + EL     +  H ++  +VSR  + E S +        D  K   V F+ EE L
Sbjct: 355 KLKVLRHELSLQQPQAGHCRI--EVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGL 412

Query: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
           D+GG  REW  L+C  + +    LF ++S +N  ++  NP+    P HL    + F GR+
Sbjct: 413 DYGGVAREWLYLLCHEMLNPYYGLF-QYSTDNIYMLQINPDSSINPDHL--SYFHFVGRI 469

Query: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
           +G  ++     G Y   +   FT  F  Q++G  +     E+ DPE +KS V +IL ND+
Sbjct: 470 MGLAVFH----GHY---INGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV-WILENDI 521

Query: 619 SE-MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVE 677
           +  ++  F  E +N  G++ +  EL   G   PVT  NK  Y+ L   +R    ++ +  
Sbjct: 522 TPVLDHTFCVE-HNAFGRILQH-ELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFL 579

Query: 678 HFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKA-----HAVVVGGSWHFREKV 732
              KG NEL+P++LL  FD+ ELEL++ G   I ++D+K+     H V           +
Sbjct: 580 ALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVA-------DSNI 632

Query: 733 MRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS----------FQIIAAPTHS 782
           +RWFW  V +  +E  ARLLQF TGS+++P  GF AL  S            +I A T  
Sbjct: 633 VRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANT-D 691

Query: 783 TLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
            LP AHTCFN++ +P Y+SYE+++  L  A+ E C GF +
Sbjct: 692 NLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETC-GFAV 730


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score =  184 bits (468), Expect = 2e-46
 Identities = 131/386 (33%), Positives = 199/386 (51%), Gaps = 22/386 (5%)

Query: 439  FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKN-FEVVFQD 497
            F+ K+  F R+L      +   K+ L + R  LLE +      +S  +  +N   V F  
Sbjct: 1227 FEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVG 1286

Query: 498  EEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRP-AHLRLKMYEFAG 556
            EE LD+ GP RE+F L+ + LF+    LF  +S N+   V  +P        L+ + F+G
Sbjct: 1287 EEGLDYSGPSREFFFLLSQELFNPYYGLF-EYSANDTYTVQISPMSAFVENHLEWFRFSG 1345

Query: 557  RLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNN 616
            R++G  L        ++ L+ A FTR F   ++ L       E  D EF++S      NN
Sbjct: 1346 RILGLALI-------HQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNN 1398

Query: 617  DMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKE 674
                ++L F   EE +   GQ+ +  EL +GGA T VT  NK  Y+  + ++R+   V +
Sbjct: 1399 ITDILDLTFTVNEEVF---GQVTER-ELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQ 1454

Query: 675  EVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMR 734
            + E  ++G  E+V   L+++FD  ELEL++ GT +I ++D++ +    GG +H    V+R
Sbjct: 1455 QTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGG-YHDGHLVIR 1513

Query: 735  WFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHT 789
            WFW  V     E+  RLLQF TG+S +P  GFAAL  S     F I      ++LP AHT
Sbjct: 1514 WFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHT 1573

Query: 790  CFNQLCLPTYDSYEEVHRMLQLAISE 815
            CFN+L LP Y SY  ++  L  A+ E
Sbjct: 1574 CFNRLDLPPYPSYSMLYEKLLTAVEE 1599


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
           sapiens]
          Length = 748

 Score =  183 bits (465), Expect = 5e-46
 Identities = 128/391 (32%), Positives = 201/391 (51%), Gaps = 28/391 (7%)

Query: 442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEAL 501
           K+   ++EL Q   +  H ++  +VSR  + E S +        D  K   + F+ EE L
Sbjct: 375 KLKILRQELSQQQPQAGHCRI--EVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGL 432

Query: 502 DWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPN---RPAHLRLKMYEFAGRL 558
           D+GG  REW  L+   + +    LF ++S ++   +  NP+    P HL    + F GR+
Sbjct: 433 DYGGVAREWLYLLSHEMLNPYYGLF-QYSRDDIYTLQINPDSAVNPEHL--SYFHFVGRI 489

Query: 559 VGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDM 618
           +G  ++     G Y   +   FT  F  Q++G  +     E  DP+ + S V  + N+  
Sbjct: 490 MGMAVFH----GHY---IDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDIT 542

Query: 619 SEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEH 678
             ++  F  E +N  G++ +  EL   G   PV   NK  Y+ L   +R    ++ +   
Sbjct: 543 GVLDHTFCVE-HNAYGEIIQH-ELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA 600

Query: 679 FLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWT 738
             KG NE++P++LL  FDE ELEL++CG G I V+D+K +  +   +      +++WFW 
Sbjct: 601 LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPD--SNIVKWFWK 658

Query: 739 VVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQI--IAAPTHSTLPTAHTCF 791
            V    +E  ARLLQF TGSS++P  GF AL  +     F I  I A T++ LP AHTCF
Sbjct: 659 AVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNN-LPKAHTCF 717

Query: 792 NQLCLPTYDSYEEVHRMLQLAISEGCEGFGM 822
           N++ +P Y+SYE+++  L  AI E C GF +
Sbjct: 718 NRIDIPPYESYEKLYEKLLTAIEETC-GFAV 747


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
           [Homo sapiens]
          Length = 922

 Score =  182 bits (461), Expect = 1e-45
 Identities = 127/373 (34%), Positives = 189/373 (50%), Gaps = 28/373 (7%)

Query: 460 SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALF 519
           S V + VSR  L E S +        D  +   V+F+ EE LD+GG  REWF L+   + 
Sbjct: 565 SHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVL 624

Query: 520 DTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVR 577
           +    LF     NN  L ++P     P HL    + F GR +   L+         + + 
Sbjct: 625 NPMYCLFEYAGKNNYCLQINPASTINPDHL--SYFCFIGRFIAMALFHG-------KFID 675

Query: 578 ARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEKYNKSGQ 635
             F+  F  +++  ++  K  E+ D EFY S + +I +N++ E  +E+ F+ +       
Sbjct: 676 TGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLI-WIRDNNIEECGLEMYFSVDMEI---- 730

Query: 636 LDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA 693
           L KV   +L  GG+   VT  NK  Y+ L+ ++R +  V+E+ + FL G NE+VP   L 
Sbjct: 731 LGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQ 790

Query: 694 IFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQ 753
            FDE ELE+++CG  ++ ++D++ + V     +    K + WFW  V     E   RLLQ
Sbjct: 791 YFDEKELEVMLCGMQEVDLADWQRNTVY--RHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 848

Query: 754 FTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRM 808
           F TG+ +LP GGFA L  S     F I      + LP +HTCFN+L LP Y SYE++   
Sbjct: 849 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 908

Query: 809 LQLAISEGCEGFG 821
           L  AI E  EGFG
Sbjct: 909 LLFAIEE-TEGFG 920


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
            ligase 2 [Homo sapiens]
          Length = 1572

 Score =  180 bits (457), Expect = 4e-45
 Identities = 128/387 (33%), Positives = 202/387 (52%), Gaps = 24/387 (6%)

Query: 439  FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKN-FEVVFQD 497
            F+ K+  F R+L      +   K+ L + R  LLE +      +S  D  +N   V F  
Sbjct: 1193 FEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG 1252

Query: 498  EEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRP-AHLRLKMYEFAG 556
            EE LD+ GP RE+F L+ + LF+    LF  +S N+   V  +P         + + F+G
Sbjct: 1253 EEGLDYSGPSREFFFLVSRELFNPYYGLF-EYSANDTYTVQISPMSAFVDNHHEWFRFSG 1311

Query: 557  RLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNN 616
            R++G  L        ++ L+ A FTR F   ++ +       E  D EF++S + ++ +N
Sbjct: 1312 RILGLALI-------HQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQS-LQWMKDN 1363

Query: 617  DMSE-MELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVK 673
            D+ + ++L F   EE +   GQ+ +  EL  GGA  PVT  NK  Y+  + ++R+   V 
Sbjct: 1364 DIHDILDLTFTVNEEVF---GQITER-ELKPGGANIPVTEKNKKEYIERMVKWRIERGVV 1419

Query: 674  EEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM 733
            ++ E  ++G  E+V   L+++FD  ELEL++ GT +I +SD++ +    GG +H    V+
Sbjct: 1420 QQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGG-YHDNHIVI 1478

Query: 734  RWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAH 788
            RWFW  V     E+  RLLQF TG+S +P  GFA+L  S     F +      + LP AH
Sbjct: 1479 RWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAH 1538

Query: 789  TCFNQLCLPTYDSYEEVHRMLQLAISE 815
            TCFN+L LP Y S+  ++  L  A+ E
Sbjct: 1539 TCFNRLDLPPYPSFSMLYEKLLTAVEE 1565


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  146 bits (369), Expect = 7e-35
 Identities = 130/424 (30%), Positives = 205/424 (48%), Gaps = 40/424 (9%)

Query: 399  LTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQR----ELRQVH 454
            L   +D G++ P     +ER +   T +  +         F+++V  FQR    + ++V 
Sbjct: 662  LQSTLDVGLESPPLSVSEERQLAVLTELPFV-------VPFEERVKIFQRLIYADKQEVQ 714

Query: 455  MKRPH-SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQ-----DEEALDWGGPRR 508
               P    + + + R+ + E +       +  D  K   V        DE  +D GG  R
Sbjct: 715  GDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFR 774

Query: 509  EWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLR---LKMYEFAGRLVGKCLYE 565
            E+   + K+ F+  NQ F  F   N+ L++PNP     +     + Y F GR++GK LYE
Sbjct: 775  EFLNELLKSGFNP-NQGF--FKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYE 831

Query: 566  SSLGGAYKQLVRARFTRSFLAQIIGLR--MHYKYFETDDPEFYKSKVCF-ILNNDMSEME 622
            +        LV   F   FL++++G    +   +  + DPE YK+ +      +D+ E+ 
Sbjct: 832  N-------MLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELG 884

Query: 623  LVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKG 682
            L F     N  G+  +VVEL  GG   PVT+AN+I Y++L+A YRL  Q+++    F +G
Sbjct: 885  LNFTVVN-NDLGEA-QVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQG 942

Query: 683  LNELVPENLLAIFDENELELLMCGTG-DISVSDFKAHAVVVGGSWHFREKVMRWFWTVVS 741
            L  +V    L +FD+ E+++L+ G    IS+ D K+     GG +     V++ FW VV 
Sbjct: 943  LANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG-YSADHPVIKVFWRVVE 1001

Query: 742  SLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH-STLPTAHTCFNQLCLPTYD 800
              T EE  +LL+F T  S+ P  GF  L P+F I    +    LPTA TC N L LP + 
Sbjct: 1002 GFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF- 1060

Query: 801  SYEE 804
             Y+E
Sbjct: 1061 -YDE 1063


>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score =  146 bits (368), Expect = 9e-35
 Identities = 118/397 (29%), Positives = 184/397 (46%), Gaps = 54/397 (13%)

Query: 458  PH-SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQ-----DEEALDWGGPRREWF 511
            PH + +T++ SR  +LE   +  R  S         V F      DE  +D  G  +E+ 
Sbjct: 678  PHVTHITIRRSR--MLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735

Query: 512  ELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLR-LKMYEFAGRLVGKCLYESSLGG 570
            E I K +FD    LF   S + +  ++P+P    H   L+++EF G+++GK +YE  +  
Sbjct: 736  EEIIKRVFDPALNLFKTTSGDER--LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIV-- 791

Query: 571  AYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI-LNNDMSEMELV 624
                 V   F   FL+Q++G      Y   D     D EFYK+       + D++++ L 
Sbjct: 792  -----VDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLT 846

Query: 625  FAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLN 684
             + ++ +  GQL    EL+ GG   PVTN NKI Y++L+A +R+ +Q+K +    + G  
Sbjct: 847  LSYDE-DVMGQL-VCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFR 904

Query: 685  ELVPENLLAIFDENELELLMCG-TGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSS- 742
             ++    + +F   EL+ L+ G   +I + D K H V  GG +H   +V+ W W +++S 
Sbjct: 905  SIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGG-FHGSHRVIIWLWDILASD 963

Query: 743  LTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH--------------------- 781
             T +E A  L+F T  S+ P  GFA L P F I                           
Sbjct: 964  FTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRK 1023

Query: 782  ----STLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
                  LPT+ TCFN L LP Y     +   L+ AIS
Sbjct: 1024 REPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAIS 1060


>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score =  146 bits (368), Expect = 9e-35
 Identities = 118/397 (29%), Positives = 184/397 (46%), Gaps = 54/397 (13%)

Query: 458  PH-SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQ-----DEEALDWGGPRREWF 511
            PH + +T++ SR  +LE   +  R  S         V F      DE  +D  G  +E+ 
Sbjct: 678  PHVTHITIRRSR--MLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFL 735

Query: 512  ELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLR-LKMYEFAGRLVGKCLYESSLGG 570
            E I K +FD    LF   S + +  ++P+P    H   L+++EF G+++GK +YE  +  
Sbjct: 736  EEIIKRVFDPALNLFKTTSGDER--LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIV-- 791

Query: 571  AYKQLVRARFTRSFLAQIIGLRMHYKYFETD-----DPEFYKSKVCFI-LNNDMSEMELV 624
                 V   F   FL+Q++G      Y   D     D EFYK+       + D++++ L 
Sbjct: 792  -----VDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLT 846

Query: 625  FAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLN 684
             + ++ +  GQL    EL+ GG   PVTN NKI Y++L+A +R+ +Q+K +    + G  
Sbjct: 847  LSYDE-DVMGQL-VCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFR 904

Query: 685  ELVPENLLAIFDENELELLMCG-TGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSS- 742
             ++    + +F   EL+ L+ G   +I + D K H V  GG +H   +V+ W W +++S 
Sbjct: 905  SIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGG-FHGSHRVIIWLWDILASD 963

Query: 743  LTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTH--------------------- 781
             T +E A  L+F T  S+ P  GFA L P F I                           
Sbjct: 964  FTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRK 1023

Query: 782  ----STLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
                  LPT+ TCFN L LP Y     +   L+ AIS
Sbjct: 1024 REPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAIS 1060


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  128 bits (322), Expect = 2e-29
 Identities = 105/369 (28%), Positives = 181/369 (49%), Gaps = 27/369 (7%)

Query: 464 LKVSRHALLESSLKATRNFSI---SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520
           LKV R  +++ +L      ++   +D  K   V F+ E+ +D GG  +E+F+L+ + +F+
Sbjct: 522 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 581

Query: 521 TTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARF 580
               +FT   D +  L   NP+  +      +   G ++G  +Y + +   +  +V  R 
Sbjct: 582 PDIGMFTY--DESTKLFWFNPS--SFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR- 636

Query: 581 TRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFIL--NNDMSEMELVFAEEKYNKSGQLDK 638
                 +++G +  ++      P  Y+S    +    N   +M + F   + +  G    
Sbjct: 637 ------KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGN-PM 689

Query: 639 VVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA-IFDE 697
           + +L   G + P+TN N+  ++NL + Y L   V+++ + F +G + +  E+ L  +F  
Sbjct: 690 MYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRP 749

Query: 698 NELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM-RWFWTVVSSLTQEELARLLQFTT 756
            E+ELL+CG+ ++     +      GG  + R+ V+ R FW +V S T E+    LQFTT
Sbjct: 750 EEIELLICGSRNLDFQALEETTEYDGG--YTRDSVLIREFWEIVHSFTDEQKRLFLQFTT 807

Query: 757 GSSQLPPGGFAALCPSFQIIA--APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
           G+ + P GG   L     IIA   P    LPT+HTCFN L LP Y S E++   L  AI+
Sbjct: 808 GTDRAPVGGLGKL---KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 864

Query: 815 EGCEGFGML 823
              +GFGML
Sbjct: 865 Y-AKGFGML 872


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  128 bits (322), Expect = 2e-29
 Identities = 105/369 (28%), Positives = 181/369 (49%), Gaps = 27/369 (7%)

Query: 464 LKVSRHALLESSLKATRNFSI---SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520
           LKV R  +++ +L      ++   +D  K   V F+ E+ +D GG  +E+F+L+ + +F+
Sbjct: 502 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 561

Query: 521 TTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARF 580
               +FT   D +  L   NP+  +      +   G ++G  +Y + +   +  +V  R 
Sbjct: 562 PDIGMFTY--DESTKLFWFNPS--SFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR- 616

Query: 581 TRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFIL--NNDMSEMELVFAEEKYNKSGQLDK 638
                 +++G +  ++      P  Y+S    +    N   +M + F   + +  G    
Sbjct: 617 ------KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGN-PM 669

Query: 639 VVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA-IFDE 697
           + +L   G + P+TN N+  ++NL + Y L   V+++ + F +G + +  E+ L  +F  
Sbjct: 670 MYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRP 729

Query: 698 NELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM-RWFWTVVSSLTQEELARLLQFTT 756
            E+ELL+CG+ ++     +      GG  + R+ V+ R FW +V S T E+    LQFTT
Sbjct: 730 EEIELLICGSRNLDFQALEETTEYDGG--YTRDSVLIREFWEIVHSFTDEQKRLFLQFTT 787

Query: 757 GSSQLPPGGFAALCPSFQIIA--APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
           G+ + P GG   L     IIA   P    LPT+HTCFN L LP Y S E++   L  AI+
Sbjct: 788 GTDRAPVGGLGKL---KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 844

Query: 815 EGCEGFGML 823
              +GFGML
Sbjct: 845 Y-AKGFGML 852


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  128 bits (322), Expect = 2e-29
 Identities = 105/369 (28%), Positives = 181/369 (49%), Gaps = 27/369 (7%)

Query: 464 LKVSRHALLESSLKATRNFSI---SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520
           LKV R  +++ +L      ++   +D  K   V F+ E+ +D GG  +E+F+L+ + +F+
Sbjct: 525 LKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFN 584

Query: 521 TTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARF 580
               +FT   D +  L   NP+  +      +   G ++G  +Y + +   +  +V  R 
Sbjct: 585 PDIGMFTY--DESTKLFWFNPS--SFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYR- 639

Query: 581 TRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFIL--NNDMSEMELVFAEEKYNKSGQLDK 638
                 +++G +  ++      P  Y+S    +    N   +M + F   + +  G    
Sbjct: 640 ------KLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGN-PM 692

Query: 639 VVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA-IFDE 697
           + +L   G + P+TN N+  ++NL + Y L   V+++ + F +G + +  E+ L  +F  
Sbjct: 693 MYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRP 752

Query: 698 NELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVM-RWFWTVVSSLTQEELARLLQFTT 756
            E+ELL+CG+ ++     +      GG  + R+ V+ R FW +V S T E+    LQFTT
Sbjct: 753 EEIELLICGSRNLDFQALEETTEYDGG--YTRDSVLIREFWEIVHSFTDEQKRLFLQFTT 810

Query: 757 GSSQLPPGGFAALCPSFQIIA--APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814
           G+ + P GG   L     IIA   P    LPT+HTCFN L LP Y S E++   L  AI+
Sbjct: 811 GTDRAPVGGLGKL---KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAIT 867

Query: 815 EGCEGFGML 823
              +GFGML
Sbjct: 868 Y-AKGFGML 875


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score =  119 bits (299), Expect = 9e-27
 Identities = 104/374 (27%), Positives = 167/374 (44%), Gaps = 28/374 (7%)

Query: 462 VTLKVSRHALLESSL-KATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFD 520
           + +KV R  L+  SL + TR  +  D  K  +V F  E  LD GG  +EWF L+ + +F 
Sbjct: 417 LNMKVRRTHLVSDSLDELTRKRA--DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFH 474

Query: 521 TTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGG------AYKQ 574
               +FT   D++    H   +         +   G L+G  +Y S           YK+
Sbjct: 475 PDYGMFTYHKDSH---CHWFSSFKCD-NYSEFRLVGILMGLAVYNSITLDIRFPPCCYKK 530

Query: 575 LVRARFTRSFLAQIIGLRMHYKYFETDD-----PEFYKSKVCFILNNDMSEMELVFAEEK 629
           L+      S     +G+         DD     PE        + +    E +     + 
Sbjct: 531 LLSPPIIPSDQNIPVGICN----VTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQV 586

Query: 630 YNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPE 689
           + +   + K   L  GG +  VTN N+  Y+ L   + L   + ++   F  G + +   
Sbjct: 587 FQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCAS 646

Query: 690 NLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELA 749
           N L +    E+E+L+CG+ D+ +   +      G  +   +  +++FW VV     +   
Sbjct: 647 NALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG--YAKTDLTIKYFWDVVLGFPLDLQK 704

Query: 750 RLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHST-LPTAHTCFNQLCLPTYDSYEEVHRM 808
           +LL FTTGS ++P GG A L  +F+I    T +  LP AHTCFNQLCLP Y S +++ + 
Sbjct: 705 KLLHFTTGSDRVPVGGMADL--NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQK 762

Query: 809 LQLAISEGCEGFGM 822
           L + IS   EGFG+
Sbjct: 763 LIIGISNS-EGFGL 775


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,330,713
Number of Sequences: 37866
Number of extensions: 1489701
Number of successful extensions: 3785
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3525
Number of HSP's gapped (non-prelim): 114
length of query: 823
length of database: 18,247,518
effective HSP length: 111
effective length of query: 712
effective length of database: 14,044,392
effective search space: 9999607104
effective search space used: 9999607104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.