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Search of human proteins with 86990456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 1070 0.0
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 487 e-138
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 481 e-136
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 478 e-135
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 476 e-134
gi|194440719 chondroadherin-like [Homo sapiens] 135 1e-31
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 130 3e-30
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 125 1e-28
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 121 2e-27
gi|198041768 synleurin [Homo sapiens] 120 3e-27
gi|153251229 chondroadherin precursor [Homo sapiens] 119 5e-27
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 119 9e-27
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 119 9e-27
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 111 1e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 111 1e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 111 1e-24
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 111 2e-24
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 109 5e-24
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 109 5e-24
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 109 5e-24
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 109 5e-24
gi|225579152 insulin-like growth factor binding protein, acid la... 108 1e-23
gi|4826772 insulin-like growth factor binding protein, acid labi... 108 1e-23
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 108 1e-23
gi|12007646 nyctalopin precursor [Homo sapiens] 104 2e-22
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 103 5e-22
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 102 1e-21
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 101 2e-21
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 101 2e-21
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 100 2e-21
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 1070 bits (2766), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEA 60
MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEA
Sbjct: 1 MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEA 60
Query: 61 PHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTL 120
PHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTL
Sbjct: 61 PHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTL 120
Query: 121 SSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRI 180
SSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRI
Sbjct: 121 SSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRI 180
Query: 181 FQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCL 240
FQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCL
Sbjct: 181 FQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCL 240
Query: 241 RRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRIL 300
RRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRIL
Sbjct: 241 RRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRIL 300
Query: 301 NSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAF 360
NSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAF
Sbjct: 301 NSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAF 360
Query: 361 HLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAE 420
HLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAE
Sbjct: 361 HLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAE 420
Query: 421 NAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQM 480
NAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQM
Sbjct: 421 NAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQM 480
Query: 481 AAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
AAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV
Sbjct: 481 AAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 487 bits (1254), Expect = e-138
Identities = 248/525 (47%), Positives = 350/525 (66%), Gaps = 17/525 (3%)
Query: 6 LGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS 65
+GL W L P + + +MLPA CP CRCE L YC++ P+
Sbjct: 1 MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD 60
Query: 66 -GLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
G LGLSLR+N ++EL QF QLTWL+LDHN I +V+ DAFQ L ++KEL LSSN+
Sbjct: 61 KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK 120
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
I LPNTTF + NL+++DLS+N+L +L P+LF+GLRKL TLH+R+N+++ +PVR+F DC
Sbjct: 121 IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC 180
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
RSL+FLD+ N+L+SLARN FAGL KL ELHLEHN L K+NFAHF RL SLH+L L+ NK
Sbjct: 181 RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK 240
Query: 245 VAIVVSSLDWVW-NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
++ + ++W W LEK+DL+GNEI+ ++ VFET+P+L+ L +D+N+L ++ +ILNS
Sbjct: 241 ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL 300
Query: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
+SLT++ L+GNLW+C +CALASWL +FQGR++ ++ C SP++ QGED+LDAV+ F LC
Sbjct: 301 RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC 360
Query: 364 EDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFE---PATVALPGGEH-- 418
+L + VT + ++ T H G E A +A+ EH
Sbjct: 361 --------WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFP 412
Query: 419 -AENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTM 477
+NA+ +V+TGTMAL+FSF ++ ++++S KC P +LR++RQC + Q +Q + QT
Sbjct: 413 EPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTR 472
Query: 478 HQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
M+ MS Q Y +Y+P H EG +IIN YG C C Q P +ECEV
Sbjct: 473 LHMSNMSDQGPYNEYEPTH-EGPFIIINGYGQCKCQQLPYKECEV 516
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 481 bits (1237), Expect = e-136
Identities = 246/521 (47%), Positives = 358/521 (68%), Gaps = 23/521 (4%)
Query: 13 LLRRPSGVVLCLLGA---CFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS-GLL 68
++R SG + L+ A ML +A GCP+ CRCEG+++YCE+ L E P ++S G L
Sbjct: 5 VIRLLSGSAVALVIAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCL 64
Query: 69 GLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQL 128
GLSLRYNSL +L+ QF GL QLTWLYLDHNHI ++ +AF +RR+KEL LSSN+I+
Sbjct: 65 GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYF 124
Query: 129 PNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLK 188
N TFRP+ NLR++DLSYN+L +L + F GLRKL +LH+R+N+++ +PVRIFQDCR+L+
Sbjct: 125 LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLE 184
Query: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248
LD+GYN+++SLARN FAG+ +L ELHLEHN K+N A FPRL+SL +L L+ NK++++
Sbjct: 185 LLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVI 244
Query: 249 VSSLDWVW-NLEKMDLSGNEIE-YMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSL 306
++ W W +L+++DLSGNEIE + P VF+ VP+LQ L LDSN+LT+I IL+SW SL
Sbjct: 245 GQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISL 304
Query: 307 TSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCEDG 366
I+LAGN+W+C RN+C+L +WL +F+G + + CASP+ QG +V+DAV + +C
Sbjct: 305 NDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICG-- 362
Query: 367 AEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFE-PATVAL--PGGEHAENA- 422
+ T R DL T +H+ P TV PG E +A
Sbjct: 363 ---------KSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGPETDADAE 413
Query: 423 -VQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMA 481
+ HK++ G++AL S L+++LV+YVSWK +PAS++QL+Q + +R ++K++Q++ QM
Sbjct: 414 HISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLKQMT 473
Query: 482 AMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
S QE+YVDYKP + E + +++N G CT ++ +RECE+
Sbjct: 474 P-STQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEI 513
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 478 bits (1229), Expect = e-135
Identities = 245/527 (46%), Positives = 344/527 (65%), Gaps = 19/527 (3%)
Query: 6 LGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS 65
+G L L+ S V++ L ML A CP+ CRC+G+++YCE+ + P N+S
Sbjct: 1 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
Query: 66 G-LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
G GLSLR+NS+ +L++ QF GL QL WLYLDHN+I SV DAFQ +RR+KEL LSSN+
Sbjct: 61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
IT L N TF P+PNLR++DLSYNKLQ L + F GLRKL LH+R+N+++ VP+R+FQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
R+L FLD+GYN+L+SL+RN+FAGL KL ELHLEHN K+NFAHFPRL +L S+ L+ N+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
Query: 245 VAIVVSSLDWVW-NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
+ + L W W +L +DLSGN+I+ +EP F+ +P+LQ L LDSN+LT I +N+W
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
Query: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
SL SITL+GN+W+C R++C L WL NF+G + + CA P++ QGE V DAV +++C
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
Query: 364 EDGAEPTSGHLLSAVTNRSDLGPPASSATTLADG----GEGQHDGTFEPATVA----LPG 415
+ + T RS L P + TFE + + +PG
Sbjct: 361 SE--------VQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPG 412
Query: 416 GEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQ 475
E V HK++ G++AL S +++LV+YVSWK +PAS++QL+Q + +RR++K ++
Sbjct: 413 AEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARE 472
Query: 476 TMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
+ QM + QEYYVDYKP + E + +N G CT +RECEV
Sbjct: 473 SERQMNS-PLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEV 518
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 476 bits (1226), Expect = e-134
Identities = 244/527 (46%), Positives = 344/527 (65%), Gaps = 19/527 (3%)
Query: 6 LGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLS 65
+G L L+ S V++ L ML A CP+ CRC+G+++YCE+ + P N+S
Sbjct: 1 MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS 60
Query: 66 G-LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
G GLSLR+NS+ +L++ QF GL QL WLYLDHN+I SV DAFQ +RR+KEL LSSN+
Sbjct: 61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK 120
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
IT L N TF P+PNLR++DLSYNKLQ L + F GLRKL LH+R+N+++ VP+R+FQDC
Sbjct: 121 ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC 180
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
R+L FLD+GYN+L+SL+RN+FAGL KL ELHLEHN K+NFAHFPRL +L S+ L+ N+
Sbjct: 181 RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR 240
Query: 245 VAIVVSSLDWVW-NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
+ + L W W +L +DLSGN+I+ +EP F+ +P+LQ L LDSN+LT I +N+W
Sbjct: 241 IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW 300
Query: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
SL SITL+GN+W+C R++C L WL NF+G + + CA P++ QGE V DAV +++C
Sbjct: 301 ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC 360
Query: 364 EDGAEPTSGHLLSAVTNRSDLGPPASSATTLADG----GEGQHDGTFEPATVA----LPG 415
+ + T RS L P + TFE + + +PG
Sbjct: 361 SE--------VQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPG 412
Query: 416 GEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQ 475
E V HK++ G++AL S +++LV+YVSWK +PAS++QL+Q + +RR++K ++
Sbjct: 413 AEQEYEHVSFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARE 472
Query: 476 TMHQMAAMSAQEYYVDYKPNHIEGALVIINEYGSCTCHQQPARECEV 522
+ QM + QEYYVDYKP + E + +N G CT +RECE+
Sbjct: 473 SERQMNS-PLQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEM 518
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 135 bits (339), Expect = 1e-31
Identities = 124/405 (30%), Positives = 174/405 (42%), Gaps = 17/405 (4%)
Query: 20 VVLCLLGACFQMLPAAPSGCPQLCRCEG--RLLYCEALNLTEAPHNLSGLLG-LSLRYNS 76
+VL LL Q AA CPQ C C+ R + C NLTE P + L L L+ N
Sbjct: 17 LVLLLLAPARQ---AAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNL 73
Query: 77 LSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPM 136
L + A F G+ LT L L H + V AF+ L R+ L L+SN + +LP +
Sbjct: 74 LKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGL 133
Query: 137 PNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQ 196
+LR ++L N L+ L P F L L TL++ NA+ ++P FQ +++L + +N
Sbjct: 134 GSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNA 193
Query: 197 LKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVW 256
L LA + AGL L L L HN+L + + L L L N +
Sbjct: 194 LSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLAL 253
Query: 257 -NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
L ++ L G ++ + P F P L +L L N+L + P L L + L GN
Sbjct: 254 PGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNP 311
Query: 316 WDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHL-CEDGAEPTSGHL 374
CG L WL + R DG C P +GE LDA+ + L C A L
Sbjct: 312 LWCGCQARPLLEWLARARVRSDG--ACQGPRRLRGE-ALDALRPWDLRCPGDAAQEEEEL 368
Query: 375 LSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHA 419
R+ GP A GE + A V +P H+
Sbjct: 369 ----EERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHS 409
Score = 101 bits (252), Expect = 1e-21
Identities = 95/357 (26%), Positives = 141/357 (39%), Gaps = 54/357 (15%)
Query: 35 APSGCPQLCRC--EGRLLYCEALNLTEAPHN-------------------------LSGL 67
A + CP+ C C E R CE L P L L
Sbjct: 392 AVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
Query: 68 LGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQ 127
+ L L++ ++EL AG GL +L +LYL N + + A + R+ L L N+ Q
Sbjct: 452 VSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQ 511
Query: 128 LPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSL 187
+P R +P+L S+ L N + LAP R L +++ N I V + R L
Sbjct: 512 VPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPAREL 571
Query: 188 KFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAI 247
+ L + NQL+ + + GL L EL L N L + F +
Sbjct: 572 EKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGR------------- 618
Query: 248 VVSSLDWVWNLEKMDLSGNEIEYMEPHVFETV-PHLQSLQLDSNRLTYIEPRILNSWKSL 306
+L+ + L+ + +E + P F + P LQSL L N+L + L S L
Sbjct: 619 ---------SLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQL 667
Query: 307 TSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLC 363
I L+ N + C + L WL R CA+P A+G+ V A F C
Sbjct: 668 ELIDLSSNPFHCDCQLLPLHRWLTGLNLRVGAT--CATPPNARGQRVKAAAAVFEDC 722
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 130 bits (327), Expect = 3e-30
Identities = 108/352 (30%), Positives = 161/352 (45%), Gaps = 31/352 (8%)
Query: 30 QMLPAAPSGCPQLCRCEGRLLYCEALNL-TEAPHNLSGLLGLSLRYNSLSELRAGQFTGL 88
Q P A G P+L E + LNL T NL+ L L+L +N L L G F L
Sbjct: 87 QFRPDAFGGLPRLEDLE--VTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHL 144
Query: 89 MQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNK 148
L L+L N + ++ FQ L +K L L+ N + QLP F P+ +L+++ LS N
Sbjct: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
Query: 149 LQALA------------------------PDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
L L P +F L L L ++ NAI +P+ IF
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
+L FL + +N L+ L FA L L L HN L V F L +L SL L N
Sbjct: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA 324
Query: 245 VAIVVSSL-DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
+ + + + + L K+ L N + + P +F+ + L+ L L N+LT + I ++
Sbjct: 325 ITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTN 384
Query: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQ--CASPEYAQGEDV 353
+L ++ L GN W C ++ L +WL + R N+Q CA P Y +G+ V
Sbjct: 385 YNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL-LNIQTYCAGPAYLKGQVV 435
Score = 98.6 bits (244), Expect = 1e-20
Identities = 75/287 (26%), Positives = 131/287 (45%), Gaps = 10/287 (3%)
Query: 33 PAAPSGCPQLCRCEGRLLYCEALNLTEAPHNL----SGLLGLSLRYNSLSELRAGQFTGL 88
PA P CP C C + ++C L P ++ ++ + + +L G L
Sbjct: 18 PAQP--CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
Query: 89 MQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNK 148
++ +L + +C + DAF L R+++L ++ + L F + +L + L++N
Sbjct: 76 TKVVFL---NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
Query: 149 LQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGL 208
L+AL LF L L +LH++ N +Q +P R+FQ LK L++ N L L F L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 209 FKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDLSGNE 267
L L L +N L + F +L SL L L N ++ + ++ LE++ L N
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
Query: 268 IEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
I ++ +F ++ +L L L N L + + L ++L N
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 125 bits (313), Expect = 1e-28
Identities = 124/458 (27%), Positives = 198/458 (43%), Gaps = 76/458 (16%)
Query: 21 VLCLLGACFQMLPAAPSGCPQLCRCEG-RLLYCEALNLTEAPHNLS-----GLLGLSLRY 74
+L ++ C + P A CP+ C C+ + L C L P S +L SL
Sbjct: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68
Query: 75 NSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFR 134
N ++ + A F L QL L L +N I S+ F+KL R++EL L +N + L T
Sbjct: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128
Query: 135 PMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGY 194
P+ LR + + N++ L+ F GL L L + NA+ +P +F +L +L +
Sbjct: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES 188
Query: 195 NQLKSLARNSFAGLFKLTELHLEHNDL--------------------VKVN--------- 225
N+++ L +N+FA L KL L+L N+L + N
Sbjct: 189 NRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRI 248
Query: 226 FAHFPR---------------------LISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDL 263
F H PR L +L L L N+++ + + L+ + +LE +DL
Sbjct: 249 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDL 308
Query: 264 SGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVC 323
SGNE+ + P F + L+ L L +N L+ + I + +L + L GN W C +
Sbjct: 309 SGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLR 368
Query: 324 ALASWLNNF--QGR-YDGNLQCASPEYAQGE--DVLDAVYAFHLCEDG--AEPTSGHLLS 376
L W+ ++ QGR +QC P +G+ D LD ++G A+P+ L+
Sbjct: 369 GLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDD----QQLQNGSCADPSPSASLT 424
Query: 377 AVTNR--------SDLGPPASSATTLADGGEGQHDGTF 406
A R ++ PPA A L + Q G F
Sbjct: 425 ADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRF 462
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 121 bits (303), Expect = 2e-27
Identities = 91/311 (29%), Positives = 153/311 (49%), Gaps = 10/311 (3%)
Query: 65 SGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
S LL + L N +S + F L L +L L N I V+G FQ L ++ L + N
Sbjct: 192 SSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNG 250
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
I++L + F + N+ ++L +N L + +GLR L L++ NAI+ + ++ C
Sbjct: 251 ISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFC 310
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
+ L LD+ YNQL L ++F GL L L+L N + + F L +L +L LR N+
Sbjct: 311 QRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNE 370
Query: 245 VAIVVSSLDWVW----NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRIL 300
++ + + +L K+ L GN+I+ + F + L+ L L++N + I+
Sbjct: 371 ISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
Query: 301 NSWKSLTSITLAGNLWDCGRNVCALASWL--NNFQGRYDGNLQCASPEYAQGEDVLDAVY 358
S L + L + C ++ L WL NNFQ + N+ CA PE+ G+ +L+
Sbjct: 431 -SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQ--HSVNVSCAHPEWLAGQSILNVDL 487
Query: 359 AFHLCEDGAEP 369
+C+D +P
Sbjct: 488 KDFVCDDFLKP 498
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/263 (29%), Positives = 129/263 (49%), Gaps = 7/263 (2%)
Query: 57 LTEAPH---NLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLR 113
LTE P+ S + LSL +N + E+ A L L L N I ++ +F +++
Sbjct: 109 LTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ 168
Query: 114 RVKELTLSSNQITQLPNTTFRPMPN-LRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANA 172
+K L LS+N+IT L F + + L V L+ N++ + P +F L L L ++ N
Sbjct: 169 -LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNR 226
Query: 173 IQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRL 232
I+ V FQ SL+ L + N + L +F GL + EL LEHN+L +VN L
Sbjct: 227 IKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGL 286
Query: 233 ISLHSLCLRRNKV-AIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNR 291
L L + +N + I + ++ L ++DLS N++ ++ F + L+ L L NR
Sbjct: 287 RMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNR 346
Query: 292 LTYIEPRILNSWKSLTSITLAGN 314
+T+I + +L ++ L N
Sbjct: 347 VTHIADGVFRFLSNLQTLDLRNN 369
Score = 70.9 bits (172), Expect = 3e-12
Identities = 54/186 (29%), Positives = 89/186 (47%), Gaps = 28/186 (15%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
L+ + L L +N+L+ + G GL L LY+ N I + DA++ +R+ EL LS N
Sbjct: 262 LNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYN 321
Query: 124 QITQLPNTTF------------------------RPMPNLRSVDLSYNKLQAL---APDL 156
Q+T+L + F R + NL+++DL N++ A +
Sbjct: 322 QLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEA 381
Query: 157 FHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHL 216
F GL LT L ++ N I+ + + F SL+ LD+ N + S+ N+F+ L EL L
Sbjct: 382 FAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT-HLKELIL 440
Query: 217 EHNDLV 222
+ L+
Sbjct: 441 NTSSLL 446
Score = 35.0 bits (79), Expect = 0.17
Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Query: 58 TEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKE 117
+EA L+ L L L+ N + + F GL L L L++N I S+Q +AF + +KE
Sbjct: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ-THLKE 437
Query: 118 LTLSSNQI 125
L L+++ +
Sbjct: 438 LILNTSSL 445
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 120 bits (301), Expect = 3e-27
Identities = 99/365 (27%), Positives = 160/365 (43%), Gaps = 54/365 (14%)
Query: 38 GCPQLCR-CEGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQFTGLMQLTWLY 95
GC +C+ C GR + C L L+ P N + L L N++S + + TGL L LY
Sbjct: 31 GCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALY 90
Query: 96 LDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPD 155
LD+++I V AF +LR + L L++N I +L F+ + NLR++ L YN++ +
Sbjct: 91 LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRG 150
Query: 156 LFHGLRKLTTLHMRANA---------IQFVPVRI---------------FQDCRSLKFLD 191
+F+ L + L+++ N + V +RI FQ +L L
Sbjct: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
Query: 192 IGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV-S 250
+G N L + N+F L L L L HN + + F L +L L L+ +++ V
Sbjct: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD 270
Query: 251 SLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNR------------------- 291
+ NL+ + LS N++E + F + +L L+LD NR
Sbjct: 271 GFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKIL 330
Query: 292 ------LTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASP 345
LT + PR+L SL + N W+C + L WL + N+ C +P
Sbjct: 331 NLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLAS--SAITLNIYCQNP 388
Query: 346 EYAQG 350
+G
Sbjct: 389 PSMRG 393
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 119 bits (299), Expect = 5e-27
Identities = 101/374 (27%), Positives = 153/374 (40%), Gaps = 60/374 (16%)
Query: 20 VVLCLLGACFQMLPAAPSGCPQLCRCEGRLLY--CEALNLTEAP---------------- 61
++L LG +LPA + CPQ C C L + C+ + L + P
Sbjct: 5 MLLLSLGLLAGLLPAL-AACPQNCHCHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNF 63
Query: 62 --------HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLR 113
+ L+ L L++ + E+ AG F GL QL +LYL HN I ++ AF L
Sbjct: 64 PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
Query: 114 RVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
+ L L N++T+LP P+ NL + L+ NK++ L F G + L L++ NA+
Sbjct: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 183
Query: 174 QFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKV---NFAHFP 230
+ D +L + NQL S + + L + EL L HN L + F F
Sbjct: 184 SSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFG 243
Query: 231 RLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSN 290
R LE + L +E F V L+ + L++N
Sbjct: 244 RY-------------------------LETLWLDNTNLEKFSDGAFLGVTTLKHVHLENN 278
Query: 291 RLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQG 350
RL + + SL ++ L N W C + L WL R D CASP +G
Sbjct: 279 RLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRRWLEAKASRPDAT--CASPAKFKG 334
Query: 351 EDVLDAVYAFHLCE 364
+ + D AF C+
Sbjct: 335 QHIRD-TDAFRSCK 347
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 119 bits (297), Expect = 9e-27
Identities = 87/309 (28%), Positives = 143/309 (46%), Gaps = 9/309 (2%)
Query: 67 LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQIT 126
LL L L N +S + F L QL L L+ N I +V G FQ L +K L + N +T
Sbjct: 194 LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 252
Query: 127 QLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRS 186
+L + F + N+ + L +N L + +GL L LH+ NAI + ++ C+
Sbjct: 253 KLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 312
Query: 187 LKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA 246
L LD+ +N L L +SF GL L LH+ +N + + F L SL +L L+ N+++
Sbjct: 313 LSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 372
Query: 247 IVVSSLDWVWN----LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNS 302
+ ++ ++ L ++ L GN I + F + L+ L L N + ++ +
Sbjct: 373 WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 432
Query: 303 WKSLTSITLAGNLWDCGRNVCALASWL--NNFQGRYDGNLQCASPEYAQGEDVLDAVYAF 360
K L + L + C + L W+ NNFQ N CA P+ +G +
Sbjct: 433 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFV--NASCAHPQLLKGRSIFAVSPDG 490
Query: 361 HLCEDGAEP 369
+C+D +P
Sbjct: 491 FVCDDFPKP 499
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/309 (26%), Positives = 136/309 (44%), Gaps = 33/309 (10%)
Query: 34 AAPSGCPQLCRCEGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQFTGLMQL- 91
AA CP CRC G LL C L P L S + L L +N LS ++A + L L
Sbjct: 42 AAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLR 101
Query: 92 ----------------------TWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLP 129
T L L N I + + ++ + ++ L LSSN I++L
Sbjct: 102 EVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL- 160
Query: 130 NTTFRPMPNLRSVDLSYNKLQALAPDLFHGL-RKLTTLHMRANAIQFVPVRIFQDCRSLK 188
T F P L+ + L+ N++ ++ P F L L L + N I +P ++F+ L+
Sbjct: 161 QTAF-PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQ 218
Query: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248
L++ N++K++ +F GL L L ++ N + K+ F L ++ L L N + +
Sbjct: 219 HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI 278
Query: 249 VSSLDWVWN---LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKS 305
W++ L+++ LS N I + P +E L L L N L+ ++
Sbjct: 279 TKG--WLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL 336
Query: 306 LTSITLAGN 314
L ++ + N
Sbjct: 337 LNTLHIGNN 345
Score = 76.3 bits (186), Expect = 7e-14
Identities = 52/186 (27%), Positives = 95/186 (51%), Gaps = 27/186 (14%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
LS + L L +N+L+E+ G GL+ L L+L N I + DA++ +++ EL L+ N
Sbjct: 262 LSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 321
Query: 124 QITQLPNTTF------------------------RPMPNLRSVDLSYNKLQALAPDL--- 156
+++L +++F R + +L+++DL N++ D+
Sbjct: 322 HLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGA 381
Query: 157 FHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHL 216
F GL KL L ++ N I+ + + F +L+ LD+ N + SL N+F+ + KL +LHL
Sbjct: 382 FSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 441
Query: 217 EHNDLV 222
+ L+
Sbjct: 442 NTSSLL 447
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 119 bits (297), Expect = 9e-27
Identities = 87/309 (28%), Positives = 143/309 (46%), Gaps = 9/309 (2%)
Query: 67 LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQIT 126
LL L L N +S + F L QL L L+ N I +V G FQ L +K L + N +T
Sbjct: 134 LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
Query: 127 QLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRS 186
+L + F + N+ + L +N L + +GL L LH+ NAI + ++ C+
Sbjct: 193 KLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 252
Query: 187 LKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA 246
L LD+ +N L L +SF GL L LH+ +N + + F L SL +L L+ N+++
Sbjct: 253 LSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312
Query: 247 IVVSSLDWVWN----LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNS 302
+ ++ ++ L ++ L GN I + F + L+ L L N + ++ +
Sbjct: 313 WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
Query: 303 WKSLTSITLAGNLWDCGRNVCALASWL--NNFQGRYDGNLQCASPEYAQGEDVLDAVYAF 360
K L + L + C + L W+ NNFQ N CA P+ +G +
Sbjct: 373 MKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFV--NASCAHPQLLKGRSIFAVSPDG 430
Query: 361 HLCEDGAEP 369
+C+D +P
Sbjct: 431 FVCDDFPKP 439
Score = 76.3 bits (186), Expect = 7e-14
Identities = 52/186 (27%), Positives = 95/186 (51%), Gaps = 27/186 (14%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
LS + L L +N+L+E+ G GL+ L L+L N I + DA++ +++ EL L+ N
Sbjct: 202 LSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 261
Query: 124 QITQLPNTTF------------------------RPMPNLRSVDLSYNKLQALAPDL--- 156
+++L +++F R + +L+++DL N++ D+
Sbjct: 262 HLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGA 321
Query: 157 FHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHL 216
F GL KL L ++ N I+ + + F +L+ LD+ N + SL N+F+ + KL +LHL
Sbjct: 322 FSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHL 381
Query: 217 EHNDLV 222
+ L+
Sbjct: 382 NTSSLL 387
Score = 58.5 bits (140), Expect = 1e-08
Identities = 54/268 (20%), Positives = 108/268 (40%), Gaps = 52/268 (19%)
Query: 96 LDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPN------------------------- 130
L HN + ++ + L+ ++E+ L++N++ +PN
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80
Query: 131 --------------------TTFRPMPNLRSVDLSYNKLQALAPDLFHGL-RKLTTLHMR 169
T P L+ + L+ N++ ++ P F L L L +
Sbjct: 81 LKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLN 140
Query: 170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHF 229
N I +P ++F+ L+ L++ N++K++ +F GL L L ++ N + K+ F
Sbjct: 141 RNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAF 199
Query: 230 PRLISLHSLCLRRNKVAIVVSSLDWVWN---LEKMDLSGNEIEYMEPHVFETVPHLQSLQ 286
L ++ L L N + + W++ L+++ LS N I + P +E L L
Sbjct: 200 WGLSNMEILQLDHNNLTEITKG--WLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257
Query: 287 LDSNRLTYIEPRILNSWKSLTSITLAGN 314
L N L+ ++ L ++ + N
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Score = 42.7 bits (99), Expect = 8e-04
Identities = 40/175 (22%), Positives = 83/175 (47%), Gaps = 26/175 (14%)
Query: 143 DLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVP-------------------VRI--- 180
DLS+N+L + L+ L + + N ++ +P V I
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 181 -FQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLI-SLHSL 238
++ +SL+ LD+ N + L + +F L +L L+L N + + +F L +L L
Sbjct: 80 HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
Query: 239 CLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLT 293
L RN+++ + + + L+ ++L+ N+I+ ++ F+ + L+SL++ N +T
Sbjct: 138 KLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
Score = 42.4 bits (98), Expect = 0.001
Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 4/108 (3%)
Query: 191 DIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKV-NFAHFPRLISLHSLCLRRNKVAIVV 249
D+ +N+L + +S + L L E+ L +N+L + N I+L SL R V I+
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNR-IVEILP 78
Query: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEP 297
L +LE +DLS N I ++ F + L+ L L+SNR+T +EP
Sbjct: 79 EHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEP 124
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 111 bits (278), Expect = 1e-24
Identities = 104/356 (29%), Positives = 146/356 (41%), Gaps = 57/356 (16%)
Query: 8 LCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNL-SG 66
L L WLL V G P AP C C C G L C L P +L S
Sbjct: 18 LLLLWLLLLRLEPVTAAAG------PRAP--CAAACTCAGDSLDCGGRGLAALPGDLPSW 69
Query: 67 LLGLSLRYNSLSELRAGQFTGLMQLTWLYLD-----------------------HNHICS 103
L+L YN LSE+ F L L +YL+ HN I S
Sbjct: 70 TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRS 129
Query: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGL-RK 162
V+G + ++ L LS N IT++ NT F P ++ ++L+ N++ L F GL R
Sbjct: 130 VEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRS 189
Query: 163 LTTLHMRANAIQFVPVR-----------------------IFQDCRSLKFLDIGYNQLKS 199
L TL + N I +PVR FQ SL+ L + N +
Sbjct: 190 LLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK 249
Query: 200 LARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNL 258
L +F GL K+ LHLE+N LV+VN L +LH L L N +A I + L
Sbjct: 250 LTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKL 309
Query: 259 EKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
++ LS N + ++ + L L+L N +++I +SL + L N
Sbjct: 310 HELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHN 365
Score = 105 bits (262), Expect = 1e-22
Identities = 81/307 (26%), Positives = 138/307 (44%), Gaps = 5/307 (1%)
Query: 67 LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQIT 126
LL L L N +++L F L +LT L L+ N I ++G FQ L ++ L L N I+
Sbjct: 190 LLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNIS 248
Query: 127 QLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRS 186
+L + F + + + L YN L + +GL L LH+ N+I + + + C+
Sbjct: 249 KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQK 308
Query: 187 LKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA 246
L L + +N L L S A L L+ L L HN + + F L SL L L N+++
Sbjct: 309 LHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEIS 368
Query: 247 IVVSSLDWVW----NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNS 302
+ + +L K+ L GN+I+ + F + L+ L L N + ++
Sbjct: 369 GTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVK 428
Query: 303 WKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHL 362
K+L + ++ + + C + L WL + CA PE +G+ + +
Sbjct: 429 MKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFV 488
Query: 363 CEDGAEP 369
C+D +P
Sbjct: 489 CDDFLKP 495
Score = 58.2 bits (139), Expect = 2e-08
Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 59 EAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGD---AFQKLRRV 115
E+ LS L L L +NS+S + G F GL L L LDHN I D AF L +
Sbjct: 325 ESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSL 384
Query: 116 KELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANA 172
+LTL N+I + F + L ++L N ++++ D F ++ L LH+ +++
Sbjct: 385 SKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 111 bits (278), Expect = 1e-24
Identities = 110/413 (26%), Positives = 171/413 (41%), Gaps = 36/413 (8%)
Query: 65 SGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
S L L L N L + G F L+ LT L L N + + FQ L ++ L L N+
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
+T +P TF + NL+ + L N++ L+P LFH L L++ N I +P IF
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
L L + N LK L+ F + L EL L N + + F L L L L RN+
Sbjct: 275 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 334
Query: 245 VAIV--------------------VSSLD-----WVWNLEKMDLSGNEIEYMEPHVFETV 279
++ + + LD + NL+ + L N + + ++F V
Sbjct: 335 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 394
Query: 280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRY--D 337
L ++QL +N+L + I + L + L N W C ++ L +WL Q R D
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTD 454
Query: 338 GNLQCASPEYAQGEDVL-----DAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSAT 392
C SP +G+ ++ AV + H+ E + P + + SS T
Sbjct: 455 TVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTS--VSSTT 512
Query: 393 TLADGGEGQHDGTFEPAT--VALPGGEHAENAVQIHKVVTGTMALIFSFLIVV 443
L E D T T ++ G A++ + I +V G +AL S V
Sbjct: 513 ELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACV 565
Score = 106 bits (264), Expect = 6e-23
Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 3/297 (1%)
Query: 21 VLCLLGACFQMLPAAPSGCPQLCRCE-GRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLS 78
+L L+G A GCP C C + C + P L + L + ++
Sbjct: 13 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHIT 72
Query: 79 ELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPN 138
EL F + L L ++ N + + AF+ L ++ L+L++N++ LP F+ + +
Sbjct: 73 ELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDS 132
Query: 139 LRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLK 198
L S+ LS N+L + P F L L + N ++++P F L L++G N L
Sbjct: 133 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 192
Query: 199 SLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSL-DWVWN 257
++ F L L L L N L + F L++L L L++N++ ++ L N
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 252
Query: 258 LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
L+++ LS N I + P +F +P L L L N L + I +L + L N
Sbjct: 253 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Score = 105 bits (262), Expect = 1e-22
Identities = 74/269 (27%), Positives = 133/269 (49%), Gaps = 2/269 (0%)
Query: 48 RLLYCEALNLTEAPH-NLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQG 106
++L L E+P N+S L+ L + N LS + G F L L +L L +N + +
Sbjct: 65 QILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPI 124
Query: 107 DAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTL 166
FQ L ++ L LSSNQ+ Q+ F NL+ + L N L+ + F L LT L
Sbjct: 125 GLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKL 184
Query: 167 HMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNF 226
++ N++ + R+FQ +L+ L + N+L + +F GL L EL L+ N + ++
Sbjct: 185 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP 244
Query: 227 AHFPRLISLHSLCLRRNKVAIVVSSLDW-VWNLEKMDLSGNEIEYMEPHVFETVPHLQSL 285
F +L L L N ++ + S+ + L ++ L GN ++ + +F +P+L+ L
Sbjct: 245 GLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 304
Query: 286 QLDSNRLTYIEPRILNSWKSLTSITLAGN 314
L N ++ + + ++ + L + L+ N
Sbjct: 305 WLYDNHISSLPDNVFSNLRQLQVLILSRN 333
Score = 79.0 bits (193), Expect = 1e-14
Identities = 55/182 (30%), Positives = 89/182 (48%)
Query: 62 HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLS 121
HN L L L N +S+L F L QL L L N + + F + ++EL L
Sbjct: 248 HNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLY 307
Query: 122 SNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIF 181
N I+ LP+ F + L+ + LS N++ ++P F+GL +L L + NA+Q + +F
Sbjct: 308 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVF 367
Query: 182 QDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLR 241
+ +L+ + + N+L+ L N FA + L + L++N L + F L L L L
Sbjct: 368 RMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLY 427
Query: 242 RN 243
N
Sbjct: 428 DN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 111 bits (278), Expect = 1e-24
Identities = 110/413 (26%), Positives = 171/413 (41%), Gaps = 36/413 (8%)
Query: 65 SGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQ 124
S L L L N L + G F L+ LT L L N + + FQ L ++ L L N+
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208
Query: 125 ITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
+T +P TF + NL+ + L N++ L+P LFH L L++ N I +P IF
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
L L + N LK L+ F + L EL L N + + F L L L L RN+
Sbjct: 269 PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQ 328
Query: 245 VAIV--------------------VSSLD-----WVWNLEKMDLSGNEIEYMEPHVFETV 279
++ + + LD + NL+ + L N + + ++F V
Sbjct: 329 ISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV 388
Query: 280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRY--D 337
L ++QL +N+L + I + L + L N W C ++ L +WL Q R D
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTD 448
Query: 338 GNLQCASPEYAQGEDVL-----DAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSAT 392
C SP +G+ ++ AV + H+ E + P + + SS T
Sbjct: 449 TVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTS--VSSTT 506
Query: 393 TLADGGEGQHDGTFEPAT--VALPGGEHAENAVQIHKVVTGTMALIFSFLIVV 443
L E D T T ++ G A++ + I +V G +AL S V
Sbjct: 507 ELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACV 559
Score = 106 bits (264), Expect = 6e-23
Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 3/297 (1%)
Query: 21 VLCLLGACFQMLPAAPSGCPQLCRCE-GRLLYCEALNLTEAPHNLS-GLLGLSLRYNSLS 78
+L L+G A GCP C C + C + P L + L + ++
Sbjct: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHIT 66
Query: 79 ELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPN 138
EL F + L L ++ N + + AF+ L ++ L+L++N++ LP F+ + +
Sbjct: 67 ELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDS 126
Query: 139 LRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLK 198
L S+ LS N+L + P F L L + N ++++P F L L++G N L
Sbjct: 127 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 186
Query: 199 SLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSL-DWVWN 257
++ F L L L L N L + F L++L L L++N++ ++ L N
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 246
Query: 258 LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
L+++ LS N I + P +F +P L L L N L + I +L + L N
Sbjct: 247 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Score = 105 bits (262), Expect = 1e-22
Identities = 74/269 (27%), Positives = 133/269 (49%), Gaps = 2/269 (0%)
Query: 48 RLLYCEALNLTEAPH-NLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQG 106
++L L E+P N+S L+ L + N LS + G F L L +L L +N + +
Sbjct: 59 QILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPI 118
Query: 107 DAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTL 166
FQ L ++ L LSSNQ+ Q+ F NL+ + L N L+ + F L LT L
Sbjct: 119 GLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKL 178
Query: 167 HMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNF 226
++ N++ + R+FQ +L+ L + N+L + +F GL L EL L+ N + ++
Sbjct: 179 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSP 238
Query: 227 AHFPRLISLHSLCLRRNKVAIVVSSLDW-VWNLEKMDLSGNEIEYMEPHVFETVPHLQSL 285
F +L L L N ++ + S+ + L ++ L GN ++ + +F +P+L+ L
Sbjct: 239 GLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLREL 298
Query: 286 QLDSNRLTYIEPRILNSWKSLTSITLAGN 314
L N ++ + + ++ + L + L+ N
Sbjct: 299 WLYDNHISSLPDNVFSNLRQLQVLILSRN 327
Score = 79.0 bits (193), Expect = 1e-14
Identities = 55/182 (30%), Positives = 89/182 (48%)
Query: 62 HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLS 121
HN L L L N +S+L F L QL L L N + + F + ++EL L
Sbjct: 242 HNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLY 301
Query: 122 SNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIF 181
N I+ LP+ F + L+ + LS N++ ++P F+GL +L L + NA+Q + +F
Sbjct: 302 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVF 361
Query: 182 QDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLR 241
+ +L+ + + N+L+ L N FA + L + L++N L + F L L L L
Sbjct: 362 RMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLY 421
Query: 242 RN 243
N
Sbjct: 422 DN 423
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 111 bits (277), Expect = 2e-24
Identities = 79/283 (27%), Positives = 133/283 (46%), Gaps = 5/283 (1%)
Query: 36 PSGCPQLCRCE--GRLLY--CEALNLTEAPHNLSGLLG-LSLRYNSLSELRAGQFTGLMQ 90
P+ CP C C+ G +L C L L+ P +L L L L N+L+EL+ G F L
Sbjct: 32 PTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRF 91
Query: 91 LTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQ 150
L L L NH+ + G AF L +K L L +NQ+ +P +P+L+S+ L N +
Sbjct: 92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 151
Query: 151 ALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK 210
+ F GL L L + NA+ +PVR + +L+ + + N++ + +F L
Sbjct: 152 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 211
Query: 211 LTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEY 270
L LHL +N + + F L +L +L L NK+ ++ + L+++ N I+
Sbjct: 212 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKA 271
Query: 271 MEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAG 313
+ F P LQ++ N + ++ L +++L G
Sbjct: 272 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
Score = 80.9 bits (198), Expect = 3e-15
Identities = 78/296 (26%), Positives = 125/296 (42%), Gaps = 34/296 (11%)
Query: 48 RLLYCEALNLTEAP----HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
R L+ + LTE P +NL L ++L N +S + F L L L+L +N I
Sbjct: 165 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH 224
Query: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
+ +F+ L ++ L L+ N++ + P R + L+ + N ++A+ F G L
Sbjct: 225 LGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLL 283
Query: 164 TTLHMRANAIQFVPVRIFQ-----------------------DCRSLKFLDIGYNQLKSL 200
T+H N IQFV FQ SL+ L + ++ L
Sbjct: 284 QTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLL 343
Query: 201 ARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKV-AIVVSSLDWVWNLE 259
L +L L L HN + ++ H R L + L+ N++ I + + +L+
Sbjct: 344 PSGMCQQLPRLRVLELSHNQIEELPSLH--RCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 401
Query: 260 KMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
+DLS N I + P F T+ L L L N+LT + L L + L GNL
Sbjct: 402 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGNL 454
Score = 57.4 bits (137), Expect = 3e-08
Identities = 43/127 (33%), Positives = 62/127 (48%), Gaps = 1/127 (0%)
Query: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248
+LD+ N L L F L L EL L N L + F L SL L L+ N++ +
Sbjct: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGI 129
Query: 249 VSSLDW-VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLT 307
+ W + +L+ + L N I + FE + L+ L LD N LT I R LN+ +L
Sbjct: 130 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 189
Query: 308 SITLAGN 314
++TLA N
Sbjct: 190 AMTLALN 196
Score = 53.5 bits (127), Expect = 5e-07
Identities = 42/125 (33%), Positives = 61/125 (48%), Gaps = 7/125 (5%)
Query: 110 QKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMR 169
Q+L R++ L LS NQI +LP+ L + L +N++ + D F L L L +
Sbjct: 349 QQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 406
Query: 170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFA-- 227
NAI+ + F SL LD+ NQL +L AGL L L L+ N + F+
Sbjct: 407 WNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGNLALSQAFSKD 463
Query: 228 HFPRL 232
FP+L
Sbjct: 464 SFPKL 468
Score = 32.7 bits (73), Expect = 0.83
Identities = 20/58 (34%), Positives = 30/58 (51%)
Query: 258 LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
LE++ LSGN + ++ F + L+ L L +N+L I L SL S+ L NL
Sbjct: 92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANL 149
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 109 bits (273), Expect = 5e-24
Identities = 79/282 (28%), Positives = 130/282 (46%), Gaps = 6/282 (2%)
Query: 38 GCPQLCRCE--GRLLY---CEALNLTEAPHNLSGLLG-LSLRYNSLSELRAGQFTGLMQL 91
GCP C CE GR+L C L L+E P NLS L L N++S+L L L
Sbjct: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
Query: 92 TWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQA 151
L L N + + AF L +K L L +NQ+ +P + + +L+S+ L N +
Sbjct: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
Query: 152 LAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKL 211
+ P F GL L L + NA+ +PV+ F+ +L+ + + N++ + +F L L
Sbjct: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
Query: 212 TELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYM 271
LHL +N + + F L SL +L L N + +++ + NL+++ N I +
Sbjct: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSI 272
Query: 272 EPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAG 313
F P L ++ N + ++ L ++TL G
Sbjct: 273 PEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314
Score = 99.0 bits (245), Expect = 9e-21
Identities = 71/235 (30%), Positives = 109/235 (46%), Gaps = 1/235 (0%)
Query: 58 TEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKE 117
TEA NL L L L N +S + F+GL L L+LD N + + AF+ L ++
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 118 LTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVP 177
+TL+ N+I +P+ F + +L + L N++ +L F GL L TL + N + P
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 178 VRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHS 237
I + +LK L N ++S+ +F G L +H N + V + F L L +
Sbjct: 251 TAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 238 LCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRL 292
L L L NLE + L+G +I + V +P+LQ L L N L
Sbjct: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/127 (33%), Positives = 61/127 (48%), Gaps = 1/127 (0%)
Query: 189 FLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV 248
+LD+ N + L N L L EL L N L + F L SL L L+ N++ V
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 249 -VSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLT 307
+L + +L+ + L N I Y+ P F + L+ L LD N LT I + S +L
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 308 SITLAGN 314
++TLA N
Sbjct: 190 AMTLALN 196
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/108 (34%), Positives = 55/108 (50%), Gaps = 4/108 (3%)
Query: 62 HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLS 121
+ L L L L YN L +L + F+ +L + L HN I ++ D FQ+L ++ L L+
Sbjct: 349 NQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLA 406
Query: 122 SNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLR--KLTTLH 167
N+I + F +P+L +DLS N L + HGL KLT H
Sbjct: 407 WNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNH 454
Score = 46.2 bits (108), Expect = 7e-05
Identities = 41/163 (25%), Positives = 77/163 (47%), Gaps = 6/163 (3%)
Query: 54 ALNLTEAPH--NLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQK 111
A +TE P + L L+L +S L L L L L +N + + +F
Sbjct: 315 ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
Query: 112 LRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRAN 171
++++++ L N+I ++ TF+ + +LRS++L++NK+ + P+ F L L L + +N
Sbjct: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
Query: 172 AIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTEL 214
+ P+ LK G + L+SL + K+ E+
Sbjct: 433 LLSSFPITGLHGLTHLKL--TGNHALQSLISSENFPELKVIEM 473
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (273), Expect = 5e-24
Identities = 86/313 (27%), Positives = 144/313 (46%), Gaps = 35/313 (11%)
Query: 50 LYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQ 105
+Y E LTE P LS L L + +N LS + G F GL L L+L+ N + +
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
Query: 106 GDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTT 165
F L ++ L + N I ++ + F+P+ NLRS+ ++ L + + GL L +
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
Query: 166 LHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVN 225
+ N + VP Q +LKFLD+ N + + R F+ + L EL +
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-------- 292
Query: 226 FAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPHLQS 284
+ P LIS+ SL ++D + +L K++ + N + Y+ P+ F +P L+S
Sbjct: 293 --NMPELISIDSL------------AVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 285 LQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLN----NFQGRYDGNL 340
L L+SN L+ + + S +L I++ N C + W+N N + +L
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDSL 394
Query: 341 QCASPEYAQGEDV 353
C P QG++V
Sbjct: 395 FCVDPPEFQGQNV 407
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 3/98 (3%)
Query: 219 NDLVKVNF-AHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFE 277
NDL + F A P + L L+ N +A + S D+ NL +DLS N + + +
Sbjct: 56 NDLGLLTFPARLPANTQI--LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVK 113
Query: 278 TVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
+P L S+ L+ N+LT + + L+ +L + + NL
Sbjct: 114 KMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNL 151
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (273), Expect = 5e-24
Identities = 86/313 (27%), Positives = 144/313 (46%), Gaps = 35/313 (11%)
Query: 50 LYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQ 105
+Y E LTE P LS L L + +N LS + G F GL L L+L+ N + +
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
Query: 106 GDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTT 165
F L ++ L + N I ++ + F+P+ NLRS+ ++ L + + GL L +
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
Query: 166 LHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVN 225
+ N + VP Q +LKFLD+ N + + R F+ + L EL +
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-------- 292
Query: 226 FAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPHLQS 284
+ P LIS+ SL ++D + +L K++ + N + Y+ P+ F +P L+S
Sbjct: 293 --NMPELISIDSL------------AVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 285 LQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLN----NFQGRYDGNL 340
L L+SN L+ + + S +L I++ N C + W+N N + +L
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDSL 394
Query: 341 QCASPEYAQGEDV 353
C P QG++V
Sbjct: 395 FCVDPPEFQGQNV 407
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 3/98 (3%)
Query: 219 NDLVKVNF-AHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFE 277
NDL + F A P + L L+ N +A + S D+ NL +DLS N + + +
Sbjct: 56 NDLGLLTFPARLPANTQI--LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVK 113
Query: 278 TVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
+P L S+ L+ N+LT + + L+ +L + + NL
Sbjct: 114 KMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNL 151
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (273), Expect = 5e-24
Identities = 86/313 (27%), Positives = 144/313 (46%), Gaps = 35/313 (11%)
Query: 50 LYCEALNLTEAPHN----LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQ 105
+Y E LTE P LS L L + +N LS + G F GL L L+L+ N + +
Sbjct: 121 VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMIN 180
Query: 106 GDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTT 165
F L ++ L + N I ++ + F+P+ NLRS+ ++ L + + GL L +
Sbjct: 181 SKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLES 240
Query: 166 LHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVN 225
+ N + VP Q +LKFLD+ N + + R F+ + L EL +
Sbjct: 241 ISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGIN-------- 292
Query: 226 FAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVFETVPHLQS 284
+ P LIS+ SL ++D + +L K++ + N + Y+ P+ F +P L+S
Sbjct: 293 --NMPELISIDSL------------AVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 285 LQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLN----NFQGRYDGNL 340
L L+SN L+ + + S +L I++ N C + W+N N + +L
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCD----CVIRWMNMNKTNIRFMEPDSL 394
Query: 341 QCASPEYAQGEDV 353
C P QG++V
Sbjct: 395 FCVDPPEFQGQNV 407
Score = 39.7 bits (91), Expect = 0.007
Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 3/98 (3%)
Query: 219 NDLVKVNF-AHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFE 277
NDL + F A P + L L+ N +A + S D+ NL +DLS N + + +
Sbjct: 56 NDLGLLTFPARLPANTQI--LLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVK 113
Query: 278 TVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
+P L S+ L+ N+LT + + L+ +L + + NL
Sbjct: 114 KMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNL 151
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 108 bits (270), Expect = 1e-23
Identities = 84/256 (32%), Positives = 125/256 (48%), Gaps = 9/256 (3%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
L L L L N L+ L+ F+GL +L L L N + +++ + F +L R+++L L N
Sbjct: 231 LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 290
Query: 124 QITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQD 183
I + F + LR +DLS+N++ L D F GL L L + NAI + R F+D
Sbjct: 291 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 350
Query: 184 CRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRL-----ISLHSL 238
L+ L +G+N+++ LA SF GL +L L L+HN L +V F L ++L
Sbjct: 351 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
Query: 239 CLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPR 298
CL RN V L L + L G+ + + PH F + L+ L L N L IE +
Sbjct: 411 CL-RNLPEQVFRGLG---KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 466
Query: 299 ILNSWKSLTSITLAGN 314
L L + L N
Sbjct: 467 SLWGLAELLELDLTSN 482
Score = 105 bits (263), Expect = 8e-23
Identities = 80/283 (28%), Positives = 130/283 (45%), Gaps = 2/283 (0%)
Query: 33 PAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLT 92
P A G LC +L L H L L L N LS L G F GL L
Sbjct: 153 PQALLGLENLCHLHLERNQLRSLALGTFAHT-PALASLGLSNNRLSRLEDGLFEGLGSLW 211
Query: 93 WLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQAL 152
L L N + + AF+ L ++EL L+ N++ L F + LR +DLS N L+A+
Sbjct: 212 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 271
Query: 153 APDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLT 212
++F L +L L++ N I V F ++L++LD+ +N++ L ++F GL L
Sbjct: 272 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 331
Query: 213 ELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKV-AIVVSSLDWVWNLEKMDLSGNEIEYM 271
L L HN + + F L L L L N++ + S + + LE + L N+++ +
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 391
Query: 272 EPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
+ F + ++ + L N L + ++ L S+ L G+
Sbjct: 392 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 434
Score = 105 bits (261), Expect = 1e-22
Identities = 91/308 (29%), Positives = 131/308 (42%), Gaps = 32/308 (10%)
Query: 39 CPQLCRC------EGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQFTGLMQL 91
CP C C + ++C + NLT P + G L L N+LS + F L L
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
Query: 92 TWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQA 151
+L L + S++ A L + L L NQ+ L TF P L S+ LS N+L
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
Query: 152 LAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKL 211
L LF GL L L++ N++ +P F+ SL+ L + N+L L F+GL +L
Sbjct: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
Query: 212 TELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV-------VSSLDW---------- 254
EL L N L + F +L L L L RN +A V + +L W
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 255 --------VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSL 306
+ L + LS N I + P F+ + L+ LQL NR+ + R L
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 307 TSITLAGN 314
+TL N
Sbjct: 379 EVLTLDHN 386
Score = 104 bits (259), Expect = 2e-22
Identities = 99/341 (29%), Positives = 150/341 (43%), Gaps = 36/341 (10%)
Query: 47 GRLLYCEALNLTEAPHN---------LSGLLGLS---LRYNSLSELRAGQFTGLMQLTWL 94
G L +AL + HN GLLGL L +N+++ LR F L L L
Sbjct: 298 GAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 357
Query: 95 YLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAP 154
L HN I + +F+ L +++ LTL NQ+ ++ F + N+ ++LS N L+ L
Sbjct: 358 QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 417
Query: 155 DLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTEL 214
+F GL KL +LH+ + + + F L+ L + N L + S GL +L EL
Sbjct: 418 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLEL 477
Query: 215 HLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDLSGNEIEYMEP 273
L N L + F L L L L RN++A + +L + +D+S N +E +
Sbjct: 478 DLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPN 537
Query: 274 HVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASW-LNN- 331
+ + L+ L L +N L P+ L + L GN WDCG + AL + L N
Sbjct: 538 SLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFALQNP 593
Query: 332 ------FQGRYDG-----------NLQCASPEYAQGEDVLD 355
Q +G N+ CASP G D+ D
Sbjct: 594 SAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRD 634
Score = 66.6 bits (161), Expect = 5e-11
Identities = 57/216 (26%), Positives = 100/216 (46%), Gaps = 9/216 (4%)
Query: 101 ICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGL 160
+CS DA + + SS +T+LP+ +++ L N L ++ P F L
Sbjct: 84 VCSYDDDADEL-----SVFCSSRNLTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNL 135
Query: 161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHND 220
L L+++ + + + +L L + NQL+SLA +FA L L L +N
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195
Query: 221 LVKVNFAHFPRLISLHSLCLRRNKVAIVV-SSLDWVWNLEKMDLSGNEIEYMEPHVFETV 279
L ++ F L SL L L N +A++ ++ + +L ++ L+GN + Y++P +F +
Sbjct: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
Query: 280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
L+ L L N L I+ + L + L NL
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 291
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 108 bits (270), Expect = 1e-23
Identities = 84/256 (32%), Positives = 125/256 (48%), Gaps = 9/256 (3%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSN 123
L L L L N L+ L+ F+GL +L L L N + +++ + F +L R+++L L N
Sbjct: 193 LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRN 252
Query: 124 QITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQD 183
I + F + LR +DLS+N++ L D F GL L L + NAI + R F+D
Sbjct: 253 LIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 312
Query: 184 CRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRL-----ISLHSL 238
L+ L +G+N+++ LA SF GL +L L L+HN L +V F L ++L
Sbjct: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
Query: 239 CLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPR 298
CL RN V L L + L G+ + + PH F + L+ L L N L IE +
Sbjct: 373 CL-RNLPEQVFRGLG---KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
Query: 299 ILNSWKSLTSITLAGN 314
L L + L N
Sbjct: 429 SLWGLAELLELDLTSN 444
Score = 105 bits (263), Expect = 8e-23
Identities = 80/283 (28%), Positives = 130/283 (45%), Gaps = 2/283 (0%)
Query: 33 PAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLT 92
P A G LC +L L H L L L N LS L G F GL L
Sbjct: 115 PQALLGLENLCHLHLERNQLRSLALGTFAHT-PALASLGLSNNRLSRLEDGLFEGLGSLW 173
Query: 93 WLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQAL 152
L L N + + AF+ L ++EL L+ N++ L F + LR +DLS N L+A+
Sbjct: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
Query: 153 APDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLT 212
++F L +L L++ N I V F ++L++LD+ +N++ L ++F GL L
Sbjct: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLR 293
Query: 213 ELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKV-AIVVSSLDWVWNLEKMDLSGNEIEYM 271
L L HN + + F L L L L N++ + S + + LE + L N+++ +
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 353
Query: 272 EPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
+ F + ++ + L N L + ++ L S+ L G+
Sbjct: 354 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 396
Score = 105 bits (261), Expect = 1e-22
Identities = 91/308 (29%), Positives = 131/308 (42%), Gaps = 32/308 (10%)
Query: 39 CPQLCRC------EGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQFTGLMQL 91
CP C C + ++C + NLT P + G L L N+LS + F L L
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
Query: 92 TWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQA 151
+L L + S++ A L + L L NQ+ L TF P L S+ LS N+L
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
Query: 152 LAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKL 211
L LF GL L L++ N++ +P F+ SL+ L + N+L L F+GL +L
Sbjct: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
Query: 212 TELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIV-------VSSLDW---------- 254
EL L N L + F +L L L L RN +A V + +L W
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 255 --------VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSL 306
+ L + LS N I + P F+ + L+ LQL NR+ + R L
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 307 TSITLAGN 314
+TL N
Sbjct: 341 EVLTLDHN 348
Score = 104 bits (259), Expect = 2e-22
Identities = 99/341 (29%), Positives = 150/341 (43%), Gaps = 36/341 (10%)
Query: 47 GRLLYCEALNLTEAPHN---------LSGLLGLS---LRYNSLSELRAGQFTGLMQLTWL 94
G L +AL + HN GLLGL L +N+++ LR F L L L
Sbjct: 260 GAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEEL 319
Query: 95 YLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAP 154
L HN I + +F+ L +++ LTL NQ+ ++ F + N+ ++LS N L+ L
Sbjct: 320 QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE 379
Query: 155 DLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTEL 214
+F GL KL +LH+ + + + F L+ L + N L + S GL +L EL
Sbjct: 380 QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLEL 439
Query: 215 HLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDLSGNEIEYMEP 273
L N L + F L L L L RN++A + +L + +D+S N +E +
Sbjct: 440 DLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPN 499
Query: 274 HVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASW-LNN- 331
+ + L+ L L +N L P+ L + L GN WDCG + AL + L N
Sbjct: 500 SLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFALQNP 555
Query: 332 ------FQGRYDG-----------NLQCASPEYAQGEDVLD 355
Q +G N+ CASP G D+ D
Sbjct: 556 SAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRD 596
Score = 66.6 bits (161), Expect = 5e-11
Identities = 57/216 (26%), Positives = 100/216 (46%), Gaps = 9/216 (4%)
Query: 101 ICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGL 160
+CS DA + + SS +T+LP+ +++ L N L ++ P F L
Sbjct: 46 VCSYDDDADEL-----SVFCSSRNLTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNL 97
Query: 161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHND 220
L L+++ + + + +L L + NQL+SLA +FA L L L +N
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
Query: 221 LVKVNFAHFPRLISLHSLCLRRNKVAIVV-SSLDWVWNLEKMDLSGNEIEYMEPHVFETV 279
L ++ F L SL L L N +A++ ++ + +L ++ L+GN + Y++P +F +
Sbjct: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
Query: 280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
L+ L L N L I+ + L + L NL
Sbjct: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 108 bits (270), Expect = 1e-23
Identities = 75/282 (26%), Positives = 134/282 (47%), Gaps = 2/282 (0%)
Query: 34 AAPSGCPQLCRCEG-RLLYCEALNLTEAPHNLSGLL-GLSLRYNSLSELRAGQFTGLMQL 91
AAP C C C+G R + C LT P LS L + N++++L F L
Sbjct: 24 AAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFL 83
Query: 92 TWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQA 151
L L N + + A L+ +K LTL +NQ+ +P+ R + L+S+ L N + +
Sbjct: 84 EELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS 143
Query: 152 LAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKL 211
+ D F GL +L L + N++ VPV + +L+ L + N++ S+ +F L L
Sbjct: 144 VPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
Query: 212 TELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYM 271
LHL +N + ++ F L +L +L L N + ++ + +L+++ N I +
Sbjct: 204 VVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVI 263
Query: 272 EPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAG 313
F+ P L+++ L N L+++ ++ L S+ + G
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRG 305
Score = 94.4 bits (233), Expect = 2e-19
Identities = 80/280 (28%), Positives = 126/280 (45%), Gaps = 28/280 (10%)
Query: 61 PHNLSGLLGL---SLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKE 117
P LSGL L +L+ N L + + GL L L LD NHI SV D+F+ L +++
Sbjct: 98 PKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRH 157
Query: 118 LTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVP 177
L L N +T++P +P L+++ L+ NK+ ++ F L L LH+ N I+ +
Sbjct: 158 LWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLS 217
Query: 178 VRIFQDCRSLKFLDIGYNQL-------------KSLARNS----------FAGLFKLTEL 214
F +L+ LD+ YN L K L +S F G L +
Sbjct: 218 QHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTI 277
Query: 215 HLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPH 274
HL N L V + F L LHSL +R + +L +LE + L+G +I + +
Sbjct: 278 HLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNN 337
Query: 275 VFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
+ + L++L L N + + N +L I+L N
Sbjct: 338 LCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRN 375
Score = 64.3 bits (155), Expect = 3e-10
Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 28/192 (14%)
Query: 56 NLTEAPHNLSGLLGLS---LRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKL 112
NL E P + L L NS+S + G F G L ++L N + V AF L
Sbjct: 236 NLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Query: 113 R-----------------------RVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKL 149
++ LTL+ +I+ +PN + LR++DLSYN +
Sbjct: 296 SDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNI 355
Query: 150 QALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLF 209
+ L F+G L + ++ N I + FQ SL+ LD+ N + + +FA L
Sbjct: 356 RDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLG 413
Query: 210 KLTELHLEHNDL 221
+T L + N+L
Sbjct: 414 PITNLDVSFNEL 425
Score = 46.2 bits (108), Expect = 7e-05
Identities = 35/123 (28%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 50 LYCEALNLT-----EAPHNLSG----LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNH 100
++ E+L LT P+NL L L L YN++ +L + F G L + L N
Sbjct: 319 VHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQ 376
Query: 101 ICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGL 160
I ++ FQ L ++ L LS N I ++ + F + + ++D+S+N+L + + +GL
Sbjct: 377 IYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGL 436
Query: 161 RKL 163
+L
Sbjct: 437 NQL 439
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/174 (26%), Positives = 73/174 (41%), Gaps = 26/174 (14%)
Query: 62 HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVK----- 116
HNLS L L +R S+ + + TG + L L L I S+ + Q+ + ++
Sbjct: 293 HNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
Query: 117 -----------------ELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHG 159
E++L NQI Q+ TF+ + +LR +DLS N + + F
Sbjct: 352 YNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
Query: 160 LRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLK-SLARNSFAGLFKLT 212
L +T L + N + P LK +G +LK +LA F L L+
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLKL--VGNFKLKEALAAKDFVNLRSLS 463
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/56 (35%), Positives = 31/56 (55%)
Query: 259 EKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
+ +D+S N I + F+ P L+ LQL N L++I P+ L+ K L +TL N
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNN 115
Score = 34.3 bits (77), Expect = 0.28
Identities = 15/57 (26%), Positives = 30/57 (52%)
Query: 258 LEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
LE++ L+GN++ ++ P + L+ L L +N+L + + +L S+ L N
Sbjct: 83 LEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDAN 139
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 104 bits (260), Expect = 2e-22
Identities = 119/421 (28%), Positives = 177/421 (42%), Gaps = 83/421 (19%)
Query: 25 LGACFQMLPAAPS------GCPQLCRCEGRL-----LYCEALNLT-----------EAPH 62
+GAC + PAA + GC C G L L CEA+++ A
Sbjct: 24 VGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFG 83
Query: 63 NLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHN-HICSVQGDAFQKLRRVKELTLS 121
L L LSLR+N+LS + G F GL +L L L HN + + F L R++ L L+
Sbjct: 84 TLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLA 143
Query: 122 SNQITQLP----------------NTTFRPMP-------NLRSVDLSYNKLQALAPDLFH 158
+ ++ +P + FR +P NL L +++A+A
Sbjct: 144 ACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQ 203
Query: 159 GLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEH 218
GLR+L +L ++AN ++ V F DC L+ L + N L L ++F GL +L L+L
Sbjct: 204 GLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGG 263
Query: 219 NDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFET 278
N L +V A F L L L L RN +A ++E F+
Sbjct: 264 NALDRVARAWFADLAELELLYLDRNSIA-----------------------FVEEGAFQN 300
Query: 279 VPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDG 338
+ L +L L+ NRLT + L + L N W C + L W+ GR
Sbjct: 301 LSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEG-SGRVT- 358
Query: 339 NLQCASPEYAQGEDVLDAVY---AFHLCEDGAEPTSGHLLSAVTNRSDLGP-PASSATTL 394
++ CASP G D+ + + LC D E L+ T S GP P +ATT+
Sbjct: 359 DVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEE------LNLTT--SSPGPSPEPAATTV 410
Query: 395 A 395
+
Sbjct: 411 S 411
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 103 bits (256), Expect = 5e-22
Identities = 86/305 (28%), Positives = 131/305 (42%), Gaps = 41/305 (13%)
Query: 19 GVVLCLLGACFQMLPAAPSGCPQLCRCE---------GRLLYCEALNLTEAPHNLSGLLG 69
G +LC A +L A P CP C+C G + AL L P NL+ +L
Sbjct: 4 GTLLC---AVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGL---PTNLTHILL 57
Query: 70 LSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLP 129
+ L++ F+G+ L L + +HI +V F L ++K L LS N+IT LP
Sbjct: 58 FGM---GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLP 114
Query: 130 NTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKF 189
M L + L +N L+ + ++F L L L + N + F+P +F + +LK
Sbjct: 115 GALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKL 174
Query: 190 LDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV 249
LD+ N L L + KL L L N RL+SL S
Sbjct: 175 LDLSGNNLTHLPKGLLGAQAKLERLLLHSN-----------RLVSLDS------------ 211
Query: 250 SSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
L+ + L ++ N I + P F+ +P+L SL L N L ++ + +LT +
Sbjct: 212 GLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLL 271
Query: 310 TLAGN 314
TL N
Sbjct: 272 TLFEN 276
Score = 99.4 bits (246), Expect = 7e-21
Identities = 86/305 (28%), Positives = 126/305 (41%), Gaps = 30/305 (9%)
Query: 48 RLLYCEALNLTEAPHNLSG----LLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICS 103
+LL NLT P L G L L L N L L +G L LT L NHI S
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 104 VQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKL 163
+ AF +L + LTLS N + LP+ F NL + L N L L LF + L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
Query: 164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYN-QLKSLARNSFAGLFKLTELHLEHNDLV 222
L + ++ +P F++ L++L + + +L +L + +F GL +L L L N L
Sbjct: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLT 352
Query: 223 KVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHL 282
+ L L + LRRN++ + +L F + L
Sbjct: 353 ALPDGLLRGLGKLRQVSLRRNRLRALPRAL-----------------------FRNLSSL 389
Query: 283 QSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGN--L 340
+S+QLD N+L + + + LT + L N W C + WL G G
Sbjct: 390 ESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPP 449
Query: 341 QCASP 345
+CA P
Sbjct: 450 RCAGP 454
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/296 (26%), Positives = 125/296 (42%), Gaps = 29/296 (9%)
Query: 48 RLLYCEALNLTEAPHNLSGLLGLS---LRYNSLSELRAGQFTGLMQLTWLYLDHNHICSV 104
RL+ ++ AP S L+ L L N ++ L ++ L L+LDHN + +
Sbjct: 78 RLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGI 137
Query: 105 QGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLT 164
+ FQKL ++EL L+ NQ+ LP + F + NL+ +DLS N L L L KL
Sbjct: 138 DQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLE 197
Query: 165 TLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKV 224
L + +N + + + +L L N ++S+A +F L L+ L L N L +
Sbjct: 198 RLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFL 257
Query: 225 NFAHFPRLISLHSLCLRRNKVAIV-------VSSLDWVW---------------NLEKMD 262
A F +L L L N +A + + L +W NL ++
Sbjct: 258 PSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLR 317
Query: 263 LSG----NEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
G + + F+ + LQ L L SN LT + +L L ++L N
Sbjct: 318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 102 bits (253), Expect = 1e-21
Identities = 78/275 (28%), Positives = 131/275 (47%), Gaps = 8/275 (2%)
Query: 40 PQLCRCEGRLLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHN 99
P C C+G L C+ NL P S + +SL++N + +L F L LYL +N
Sbjct: 101 PVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNN 160
Query: 100 HICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHG 159
I S+ AF+ L + +L LS N+IT L F + L + + N L ++P F+G
Sbjct: 161 KITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYG 220
Query: 160 LRKLTTLHMRANAIQFVPVR-IFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEH 218
L L L + N + +P + + Q L +LD+ N + +L +F LT L +
Sbjct: 221 LNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRK 280
Query: 219 NDLVKVNFAHFPRLISLHSLCLRRNKV----AIVVSSLDWVWNLEKMDLSGNEIEYMEPH 274
N + +N F L L L L NK+ ++ L L +++LS N I+ ++ +
Sbjct: 281 NKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLK---ELSQLNLSYNPIQKIQAN 337
Query: 275 VFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSI 309
F+ + L+SL L+ ++ I+ R+ +L+ I
Sbjct: 338 QFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
Score = 80.1 bits (196), Expect = 5e-15
Identities = 56/204 (27%), Positives = 92/204 (45%), Gaps = 25/204 (12%)
Query: 64 LSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAF-------------- 109
L+ L L L +N ++ L+ G F L +L WL ++ NH+ + F
Sbjct: 173 LNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNN 232
Query: 110 -----------QKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFH 158
Q + R+ L L N I L N TF NL + + NK+ L + F
Sbjct: 233 VLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFA 292
Query: 159 GLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEH 218
L+KL L + +N I+ +P IF+D + L L++ YN ++ + N F L KL L LE
Sbjct: 293 PLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
Query: 219 NDLVKVNFAHFPRLISLHSLCLRR 242
++ + F L++L + ++
Sbjct: 353 IEISNIQQRMFRPLMNLSHIYFKK 376
Score = 76.6 bits (187), Expect = 5e-14
Identities = 60/206 (29%), Positives = 102/206 (49%), Gaps = 10/206 (4%)
Query: 115 VKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQ 174
V ++L N I +LP F+ +L+ + L NK+ +++ F GL LT L++ N I
Sbjct: 128 VTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRIT 187
Query: 175 FVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVN----FAHFP 230
F+ +F+D L++L I N L ++ +F GL L L L +N L ++ H P
Sbjct: 188 FLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMP 247
Query: 231 RLISLHSLCLRRNKVAIVVSSLDWVW--NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLD 288
RL H L L N + + +L ++ NL + + N+I ++ + F + L L L
Sbjct: 248 RL---HWLDLEGNHIHNL-RNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLG 303
Query: 289 SNRLTYIEPRILNSWKSLTSITLAGN 314
SN++ + P I K L+ + L+ N
Sbjct: 304 SNKIENLPPLIFKDLKELSQLNLSYN 329
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/141 (28%), Positives = 69/141 (48%), Gaps = 8/141 (5%)
Query: 176 VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISL 235
VPV+ C+ L+ LD L+++ S +T + L+ N + K+ F L
Sbjct: 100 VPVQCL--CQGLE-LDCDETNLRAVPSVSS----NVTAMSLQWNLIRKLPPDCFKNYHDL 152
Query: 236 HSLCLRRNKV-AIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTY 294
L L+ NK+ +I + + + +L K+ LS N I +++P VFE + L+ L ++ N L+
Sbjct: 153 QKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR 212
Query: 295 IEPRILNSWKSLTSITLAGNL 315
I P SL + L N+
Sbjct: 213 ISPPTFYGLNSLILLVLMNNV 233
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 101 bits (251), Expect = 2e-21
Identities = 90/367 (24%), Positives = 156/367 (42%), Gaps = 20/367 (5%)
Query: 25 LGACFQMLPAA--PSGCPQLCRCEGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELR 81
+G Q+ P + CP +CRC+ +YC LT P + L L+ N ++
Sbjct: 15 IGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
Query: 82 A-GQFTGLMQLTWLYLDHNHICSVQGDAFQKL--RRVKELTLSSNQITQLPNTTFRPMPN 138
L+++ +YL HN + D F + VKEL L N I + + +P
Sbjct: 75 IPSDLKNLLKVERIYLYHNSL-----DEFPTNLPKYVKELHLQENNIRTITYDSLSKIPY 129
Query: 139 LRSVDLSYNKLQALAPD--LFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQ 196
L + L N + A++ + F L L + N + +P + + L+ D N+
Sbjct: 130 LEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD---NR 186
Query: 197 LKSLARNSFAGLFKLTELHLEHNDLVKVNFAH--FPRLISLHSLCLRRNKVAIVVSSLDW 254
+ +++ S GL L L L+ N L F L++L L L RN + +L
Sbjct: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
Query: 255 VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
NL K+ L N I + P+ F + L L + +N L+ + I + ++T + L N
Sbjct: 247 T-NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Query: 315 LWDCGRNVCALASWLNNFQGRYD-GNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGH 373
W CG + + WL + + + L C +PE +G + D C+D ++
Sbjct: 306 PWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQ 365
Query: 374 LLSAVTN 380
+ +A+ N
Sbjct: 366 ITTAIPN 372
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 101 bits (251), Expect = 2e-21
Identities = 90/367 (24%), Positives = 156/367 (42%), Gaps = 20/367 (5%)
Query: 25 LGACFQMLPAA--PSGCPQLCRCEGRLLYCEALNLTEAPHNL-SGLLGLSLRYNSLSELR 81
+G Q+ P + CP +CRC+ +YC LT P + L L+ N ++
Sbjct: 15 IGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
Query: 82 A-GQFTGLMQLTWLYLDHNHICSVQGDAFQKL--RRVKELTLSSNQITQLPNTTFRPMPN 138
L+++ +YL HN + D F + VKEL L N I + + +P
Sbjct: 75 IPSDLKNLLKVERIYLYHNSL-----DEFPTNLPKYVKELHLQENNIRTITYDSLSKIPY 129
Query: 139 LRSVDLSYNKLQALAPD--LFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQ 196
L + L N + A++ + F L L + N + +P + + L+ D N+
Sbjct: 130 LEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD---NR 186
Query: 197 LKSLARNSFAGLFKLTELHLEHNDLVKVNFAH--FPRLISLHSLCLRRNKVAIVVSSLDW 254
+ +++ S GL L L L+ N L F L++L L L RN + +L
Sbjct: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
Query: 255 VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
NL K+ L N I + P+ F + L L + +N L+ + I + ++T + L N
Sbjct: 247 T-NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Query: 315 LWDCGRNVCALASWLNNFQGRYD-GNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGH 373
W CG + + WL + + + L C +PE +G + D C+D ++
Sbjct: 306 PWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQ 365
Query: 374 LLSAVTN 380
+ +A+ N
Sbjct: 366 ITTAIPN 372
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 100 bits (250), Expect = 2e-21
Identities = 84/292 (28%), Positives = 140/292 (47%), Gaps = 16/292 (5%)
Query: 39 CPQLCRCEGRLLY-------------CEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQ 84
CP C C+ R Y C L LT P L +G L L+ NS+ + +
Sbjct: 29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSE 88
Query: 85 FTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDL 144
L LT L L N + F L ++ L L NQ+T+L + +F + +L+ + L
Sbjct: 89 LGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYL 148
Query: 145 SYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNS 204
++N+L +AP F GL L LH+ +N ++ + R F+ +L+ L IG N++ ++ +
Sbjct: 149 NHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMN 208
Query: 205 FAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV-SSLDWVWNLEKMDL 263
F L L L L +L +++ L SL SL N++A V +L+ V L+ +DL
Sbjct: 209 FRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDL 268
Query: 264 SGNEIEYMEPHVFETVPHLQSLQLDS-NRLTYIEPRILNSWKSLTSITLAGN 314
+ N ++ + P F + HL+ L L++ L I+ L + LT + + N
Sbjct: 269 NKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNN 320
Score = 99.0 bits (245), Expect = 9e-21
Identities = 80/282 (28%), Positives = 126/282 (44%), Gaps = 47/282 (16%)
Query: 62 HNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLS 121
H L LL L L N L+ L F GL L LYL+HN + + AF L + L L+
Sbjct: 114 HALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLN 173
Query: 122 SNQIT--------QLPNT----------------TFRPMPNLRSVDLSYNKLQALAPDLF 157
SN + LPN FRP+ NLRS+ L+ L+ ++
Sbjct: 174 SNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYAL 233
Query: 158 HGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLE 217
GL+ L +L N + VP R + LKFLD+ N L+ + FA + L EL L
Sbjct: 234 EGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLN 293
Query: 218 HNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGN-EIEYMEPHVF 276
+ + L+S+ +K A+V + L K+D++ N + ++ P F
Sbjct: 294 NME----------ELVSI-------DKFALVN-----LPELTKLDITNNPRLSFIHPRAF 331
Query: 277 ETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDC 318
+P +++L L++N L+ + + + S +L + L GN C
Sbjct: 332 HHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRC 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,509,093
Number of Sequences: 37866
Number of extensions: 906828
Number of successful extensions: 5191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2347
Number of HSP's gapped (non-prelim): 1100
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.