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Search of human proteins with 86788132
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
(493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 1048 0.0
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 1048 0.0
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 1048 0.0
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 514 e-146
gi|19743803 fibulin 5 precursor [Homo sapiens] 416 e-116
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 244 1e-64
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 243 3e-64
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 241 8e-64
gi|34734066 fibulin 1 isoform D [Homo sapiens] 209 6e-54
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 203 3e-52
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 203 3e-52
gi|66346695 fibrillin 2 precursor [Homo sapiens] 183 4e-46
gi|24430141 fibrillin 1 precursor [Homo sapiens] 182 8e-46
gi|118572606 hemicentin 1 [Homo sapiens] 181 2e-45
gi|56237021 fibrillin 3 precursor [Homo sapiens] 179 4e-45
gi|4557733 latent transforming growth factor beta binding protei... 167 2e-41
gi|46249414 latent transforming growth factor beta binding prote... 167 3e-41
gi|46249412 latent transforming growth factor beta binding prote... 167 3e-41
gi|194328809 latent transforming growth factor beta binding prot... 166 4e-41
gi|18497288 latent transforming growth factor beta binding prote... 166 4e-41
gi|110347437 latent transforming growth factor beta binding prot... 158 9e-39
gi|110347412 latent transforming growth factor beta binding prot... 158 9e-39
gi|110347431 latent transforming growth factor beta binding prot... 158 9e-39
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 144 1e-34
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 144 1e-34
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 137 2e-32
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 135 1e-31
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 135 1e-31
gi|10190748 CEGP1 protein [Homo sapiens] 134 2e-31
gi|189491645 fibulin 7 isoform 1 [Homo sapiens] 134 2e-31
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 1048 bits (2710), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
Query: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 481 VLRLTIIVGPFSF 493
VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 1048 bits (2710), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
Query: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 481 VLRLTIIVGPFSF 493
VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 1048 bits (2710), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
Query: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
Query: 481 VLRLTIIVGPFSF 493
VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 514 bits (1325), Expect = e-146
Identities = 241/488 (49%), Positives = 313/488 (64%), Gaps = 62/488 (12%)
Query: 7 LTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYG 66
L +L L QD+EE +YT+CTDGYEWDP Q C+D++EC +P+ACKG MKC+NHYG
Sbjct: 17 LLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYG 76
Query: 67 GYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
GYLC LP V +
Sbjct: 77 GYLC------------------------------------------LPRSAAVINDLHGE 94
Query: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRA 186
GP P P + P NP C GYE + + C D+DEC H+CR
Sbjct: 95 GPPP------------PVPPAQHP-NP-----CPPGYEPDDQDSCVDVDECAQALHDCRP 136
Query: 187 DQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLA 246
Q C NL GS+ C CP GY+K G +CVDIDEC YC RCVN PGSF CQC PGFQL
Sbjct: 137 SQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVNLPGSFRCQCEPGFQLG 195
Query: 247 ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ 306
NN +CVD+NECD C Q+C+N G+F+C+C+QGYEL D +C DIDEC SSYLCQ
Sbjct: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQ 255
Query: 307 YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPC 365
Y+CVNEPG+FSC CPQGYQ++ +R CQDI+ECE+ ++C E + C N+HGG+RC N C
Sbjct: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315
Query: 366 QDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINT 425
+PYI ENRC+CP SN +CRE P SIV++YM+I S+RSVP+D+FQIQAT++Y N
Sbjct: 316 VEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNA 375
Query: 426 FRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLT 485
F+I++GN G+FY+RQ + VSAMLVL + ++GPRE+++DLEM+T++S+ ++R SSVLRLT
Sbjct: 376 FQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLT 435
Query: 486 IIVGPFSF 493
+ VG ++F
Sbjct: 436 VFVGAYTF 443
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 416 bits (1068), Expect = e-116
Identities = 205/493 (41%), Positives = 278/493 (56%), Gaps = 52/493 (10%)
Query: 3 KALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCV 62
+ L +T+L L L + + QCT+G++ D QC DIDEC +P+AC+G M CV
Sbjct: 6 RILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60
Query: 63 NHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA 122
N GGYLC+P+T + T + G + A+A
Sbjct: 61 NQNGGYLCIPRTNPVYRGPYSNPYSTPYS------------------------GPYPAAA 96
Query: 123 AAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTH 182
++ P T S + C GY+ E N C D+DEC +H
Sbjct: 97 PPLSAPNYPT--------------------ISRPLICRFGYQMDESNQCVDVDECATDSH 136
Query: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPG 242
C Q+CIN G + C C GY QC+DIDEC YC Q C N PGS+ C C+PG
Sbjct: 137 QCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSCTCNPG 195
Query: 243 FQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
F L + +C D+NEC N C Q C N GSFIC+C+ GYEL D ++C D+DEC S
Sbjct: 196 FTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSE 255
Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHGGFRCY 360
+LCQ++CVN+PG + C CP GY ++ +R+CQDINECE N C + C+N GGF+C
Sbjct: 256 FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315
Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
C++PY+ +NRC+CP N CR+ P +I+Y+ M + S RSVP+DIFQ+QATT Y
Sbjct: 316 DPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP 375
Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
F+IKSGNE EFY+RQT P+SA LV+ + + GPRE +DLEM+TV+++ FR SS
Sbjct: 376 GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSS 435
Query: 481 VLRLTIIVGPFSF 493
V+RL I V + F
Sbjct: 436 VIRLRIYVSQYPF 448
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 244 bits (623), Expect = 1e-64
Identities = 152/472 (32%), Positives = 224/472 (47%), Gaps = 49/472 (10%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---LPKTAQIIVNNEQPQ 85
C DGY + R+ C DI+EC C G CVN G + C L + + + +
Sbjct: 752 CADGYILNAHRK-CVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECE 810
Query: 86 QETQPAEGTSGATTGVVAASSMAT----------SGVL--PGGGFV-------ASAAAVA 126
+ A GT G + ++ + G L P G V S
Sbjct: 811 DVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRP 870
Query: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCR 185
G ++ +RNP + CA GY S+ C D++EC G H C
Sbjct: 871 GFSCINTVGSYTCQRNP-------------LICARGYHASDDGTKCVDVNECETGVHRCG 917
Query: 186 ADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSP 241
QVC NL GS+ C C G+Q+ G C+D++EC P C C NT GS+ C C+
Sbjct: 918 EGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCAS 977
Query: 242 GFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDEC-RT 300
GF LAA+ C D+NEC+A +C+Q+C NI GS+ C C QGY+L+ D C DIDEC +
Sbjct: 978 GFLLAADGKRCEDVNECEAQ-RCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQG 1036
Query: 301 SSYLCQYQCVNEPGKFSCMCP-QGY-QVVRSRTCQDINECET-TNECREDEMCWNYHGGF 357
+ LC ++C+N PG + C CP QGY R+C+D++EC T+ C E E C N G F
Sbjct: 1037 AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSF 1096
Query: 358 RCYPRNPCQDPYILTPENRCVCPVSNAM--CRELPQSIVYKYMSIRSDRSVPSDIFQIQA 415
RC R C Y+ + +C + C+ P I + ++ ++ VP+ IF+I
Sbjct: 1097 RCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGP 1155
Query: 416 TTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEM 467
+ I GNE G F R+ + + ++ L +++ PR+ +D+EM
Sbjct: 1156 APAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1207
Score = 150 bits (379), Expect = 3e-36
Identities = 87/245 (35%), Positives = 117/245 (47%), Gaps = 27/245 (11%)
Query: 154 SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ----CPPGYQKRG 209
+H + CA GY + H C DI+EC H C + C+N GSF C C PGY +
Sbjct: 747 NHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD 806
Query: 210 EQCVDIDECTIPPYCHQ---RCVNTPGSFYCQ----CSPGFQLAANNYTCVDINECDASN 262
+C D+DEC + + Q C NT GSFYCQ C GF L CVDINEC + +
Sbjct: 807 GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLS 865
Query: 263 QCAQ---QCYNILGSFICQ-----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNE 312
+ + C N +GS+ CQ C +GY S D C D++EC T + C C N
Sbjct: 866 EPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNL 925
Query: 313 PGKFSCMCPQGYQ-VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
PG + C C G+Q R C D+NEC + C N G +RC C ++L
Sbjct: 926 PGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRC----SCASGFLL 981
Query: 372 TPENR 376
+ +
Sbjct: 982 AADGK 986
Score = 130 bits (328), Expect = 2e-30
Identities = 91/296 (30%), Positives = 130/296 (43%), Gaps = 30/296 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C DG+ DP C DI+EC + + C+ G C+N G Y C + I +
Sbjct: 842 RCMDGFLQDP-EGNCVDINECTSLSEPCRPGFSCINTVGSYTC-QRNPLICARGYHASDD 899
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ TGV LPG A GR + A P
Sbjct: 900 GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAF--GRGCIDVNECWASPG 957
Query: 148 RIPSNP------SHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
R+ + S+R CA+G+ ++ C+D++EC A R Q C N+ GS+ C
Sbjct: 958 RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQCY 1013
Query: 201 CPPGYQ--KRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDI 255
C GYQ + G C DIDEC C RC+N PGS+ C C G+ + AN +C D+
Sbjct: 1014 CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1073
Query: 256 NECD-ASNQC--AQQCYNILGSFIC---QCNQGY----ELSSDRLNCEDIDECRTS 301
+EC ++ C A+ C+NI GSF C +C Y + +R C D EC+ S
Sbjct: 1074 DECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1129
Score = 112 bits (280), Expect = 8e-25
Identities = 92/308 (29%), Positives = 123/308 (39%), Gaps = 64/308 (20%)
Query: 141 RNPADPQRIPSNPSH-----RIQCAAGYEQSEHNVC--QDIDECTAGTHNCRADQVCINL 193
R P +P P S R + G E N D DEC +CIN
Sbjct: 565 RRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGEL-CQHLCINT 623
Query: 194 RGSFACQCPPGY--QKRGEQC---------------------VDIDECTIP--------- 221
GS+ C C PG+ Q G C + TIP
Sbjct: 624 VGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTC 683
Query: 222 ---PYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQ--CYNILGSF 275
C Q C GS C C PG+ + A+ +C D +EC ++ C+++ C N LGSF
Sbjct: 684 KDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSF 743
Query: 276 ICQ-----CNQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEPGKFSCM----CPQGY 324
C C GY L++ R C DI+EC T + C CVN G F C C GY
Sbjct: 744 YCVNHTVLCADGYILNAHR-KCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802
Query: 325 QVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV----C 379
++ C+D++EC T+ C+ +C N G F C R C D ++ PE CV C
Sbjct: 803 -ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINEC 861
Query: 380 PVSNAMCR 387
+ CR
Sbjct: 862 TSLSEPCR 869
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 243 bits (620), Expect = 3e-64
Identities = 139/438 (31%), Positives = 214/438 (48%), Gaps = 49/438 (11%)
Query: 41 QCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTG 100
+C+D+DEC + C+ G C N G + C + + + P+ G
Sbjct: 761 ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE----------GNCVD 810
Query: 101 VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA 160
+ +S++ PG + + + + +RNP + CA
Sbjct: 811 INECTSLSEP-CRPGFSCINTVGS------------YTCQRNP-------------LICA 844
Query: 161 AGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GEQCVDIDE 217
GY S+ C D++EC G H C QVC NL GS+ C C G+Q+ G C+D++E
Sbjct: 845 RGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE 904
Query: 218 CTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSF 275
C P C C NT GS+ C C+ GF LAA+ C D+NEC+A +C+Q+C NI GS+
Sbjct: 905 CWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIYGSY 963
Query: 276 ICQCNQGYELSSDRLNCEDIDEC-RTSSYLCQYQCVNEPGKFSCMCP-QGY-QVVRSRTC 332
C C QGY+L+ D C DIDEC + + LC ++C+N PG + C CP QGY R+C
Sbjct: 964 QCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSC 1023
Query: 333 QDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM--CREL 389
+D++EC T+ C E E C N G FRC R C Y+ + +C + C+
Sbjct: 1024 KDVDECALGTHNCSEAETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNS 1082
Query: 390 PQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAML 449
P I + ++ ++ VP+ IF+I + I GNE G F R+ + + ++
Sbjct: 1083 PARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVV 1142
Query: 450 VLVKSLSGPREHIVDLEM 467
L +++ PR+ +D+EM
Sbjct: 1143 YLQRAVLEPRDFALDVEM 1160
Score = 130 bits (328), Expect = 2e-30
Identities = 91/296 (30%), Positives = 130/296 (43%), Gaps = 30/296 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C DG+ DP C DI+EC + + C+ G C+N G Y C + I +
Sbjct: 795 RCMDGFLQDP-EGNCVDINECTSLSEPCRPGFSCINTVGSYTC-QRNPLICARGYHASDD 852
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ TGV LPG A GR + A P
Sbjct: 853 GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAF--GRGCIDVNECWASPG 910
Query: 148 RIPSNP------SHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
R+ + S+R CA+G+ ++ C+D++EC A R Q C N+ GS+ C
Sbjct: 911 RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQCY 966
Query: 201 CPPGYQ--KRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDI 255
C GYQ + G C DIDEC C RC+N PGS+ C C G+ + AN +C D+
Sbjct: 967 CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1026
Query: 256 NECD-ASNQC--AQQCYNILGSFIC---QCNQGY----ELSSDRLNCEDIDECRTS 301
+EC ++ C A+ C+NI GSF C +C Y + +R C D EC+ S
Sbjct: 1027 DECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1082
Score = 118 bits (295), Expect = 1e-26
Identities = 70/220 (31%), Positives = 94/220 (42%), Gaps = 47/220 (21%)
Query: 214 DIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTC------------------- 252
D DEC + P C C+NT GS++C C PGF L + TC
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 253 --------------VDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDEC 298
N C + C Q C + GS IC C GY + +D ++CEDI+EC
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINEC 723
Query: 299 RTSSYLCQ--YQCVNEPGKFSC----MCPQGYQVVRSRTCQDINECET-TNECREDEMCW 351
T + C CVN G F C C GY ++ C+D++EC T+ C+ +C
Sbjct: 724 VTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY-ALKDGECEDVDECAMGTHTCQPGFLCQ 782
Query: 352 NYHGGFRCYPRNPCQDPYILTPENRCV----CPVSNAMCR 387
N G F C R C D ++ PE CV C + CR
Sbjct: 783 NTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCR 822
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 241 bits (616), Expect = 8e-64
Identities = 158/498 (31%), Positives = 240/498 (48%), Gaps = 36/498 (7%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 74 TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
T + + + + G + +++ + P GF+ A G
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306
Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
+ + P I + S+ Q C GY +E C D+DEC
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
C C+N GSF C+C GY G CVD++EC P C +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426
Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
S GF+L+ + +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485
Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
T ++C Y+C+N PG F C CP GY++ R CQDI+EC T + C +E C+N
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545
Query: 354 HGGFRCYPRNPCQDPYILTPENRCV---CPVSNAMCRELPQSIVYKYMSIRSDRSVPSDI 410
GGFRC C + Y + RC C N C +LP I Y ++S ++ P+ +
Sbjct: 546 QGGFRCLAFE-CPENYRRSAATRCERLPCH-ENRECSKLPLRITYYHLSFPTNIQAPAVV 603
Query: 411 FQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTV 470
F++ ++ I GNE G F R+ SP S ++ L K + PR+ ++ ++M +
Sbjct: 604 FRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DL 662
Query: 471 SSIGTFRTSSVLRLTIIV 488
S GT +S V +L I V
Sbjct: 663 SRHGTV-SSFVAKLFIFV 679
Score = 100 bits (248), Expect = 4e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 209 bits (531), Expect = 6e-54
Identities = 159/521 (30%), Positives = 240/521 (46%), Gaps = 53/521 (10%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 74 TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
T + + + + G + +++ + P GF+ A G
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306
Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
+ + P I + S+ Q C GY +E C D+DEC
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
C C+N GSF C+C GY G CVD++EC P C +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426
Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
S GF+L+ + +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485
Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
T ++C Y+C+N PG F C CP GY++ R CQDI+EC T + C +E C+N
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545
Query: 354 HGGFRCY----PRNPCQDPYILTPEN----RCV--CPVSNAMCRELP-QSIVYKYMSIRS 402
GGFRC P N + L E RC+ C ++ C P +I + +S+ +
Sbjct: 546 QGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPT 605
Query: 403 DRSV--PSDIFQIQATT-----IYANTINTFRIKSGNENGEFYL--RQTSPVSAMLV-LV 452
R P +I ++A T AN I F I GN F + R ++ +V V
Sbjct: 606 FREFTRPEEIIFLRAITPPHPASQANII--FDITEGNLRDSFDIIKRYMDGMTVGVVRQV 663
Query: 453 KSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF 493
+ + GP ++ LEM V G +V+ + I V + F
Sbjct: 664 RPIVGPFHAVLKLEMNYVVG-GVVSHRNVVNVHIFVSEYWF 703
Score = 100 bits (248), Expect = 4e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 203 bits (516), Expect = 3e-52
Identities = 121/366 (33%), Positives = 178/366 (48%), Gaps = 29/366 (7%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 74 TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
T + + + + G + +++ + P GF+ A G
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306
Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
+ + P I + S+ Q C GY +E C D+DEC
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
C C+N GSF C+C GY G CVD++EC P C +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426
Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
S GF+L+ + +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485
Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
T ++C Y+C+N PG F C CP GY++ R CQDI+EC T + C +E C+N
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545
Query: 354 HGGFRC 359
GGFRC
Sbjct: 546 QGGFRC 551
Score = 100 bits (248), Expect = 4e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
Score = 63.9 bits (154), Expect = 3e-10
Identities = 52/205 (25%), Positives = 78/205 (38%), Gaps = 50/205 (24%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
+C GY +D + + C D++EC P G KC N G YLC ++ V+ +
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 87 ETQPAEGTSGATTGVVAASSMA----------TSGV---------LPGGGFVASAAAVAG 127
+ + V S GV LP GG + S +
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI-- 499
Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCR 185
IP S + C ++GY + + CQDIDEC G HNC
Sbjct: 500 --------------------NIPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCS 537
Query: 186 ADQVCINLRGSFAC---QCPPGYQK 207
++ C N++G F C +CP Y++
Sbjct: 538 INETCFNIQGGFRCLAFECPENYRR 562
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 203 bits (516), Expect = 3e-52
Identities = 121/366 (33%), Positives = 178/366 (48%), Gaps = 29/366 (7%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
+DT + + + C GY+ C+D++EC +C+ G C+N G + C
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249
Query: 74 TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
T + + + + G + +++ + P GF+ A G
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306
Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
+ + P I + S+ Q C GY +E C D+DEC
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366
Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
C C+N GSF C+C GY G CVD++EC P C +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426
Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
S GF+L+ + +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485
Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
T ++C Y+C+N PG F C CP GY++ R CQDI+EC T + C +E C+N
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545
Query: 354 HGGFRC 359
GGFRC
Sbjct: 546 QGGFRC 551
Score = 100 bits (248), Expect = 4e-21
Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)
Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
D C C Q+C +T C C G+QL ++ +C D+NEC S+ C + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237
Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
GSF CQ C GYEL+ D +C+DIDEC + + C + C N G F C C
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296
Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
G+ C DINEC + C C N G + C P C Y L E RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355
Score = 63.9 bits (154), Expect = 3e-10
Identities = 52/205 (25%), Positives = 78/205 (38%), Gaps = 50/205 (24%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
+C GY +D + + C D++EC P G KC N G YLC ++ V+ +
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCED 441
Query: 87 ETQPAEGTSGATTGVVAASSMA----------TSGV---------LPGGGFVASAAAVAG 127
+ + V S GV LP GG + S +
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI-- 499
Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCR 185
IP S + C ++GY + + CQDIDEC G HNC
Sbjct: 500 --------------------NIPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCS 537
Query: 186 ADQVCINLRGSFAC---QCPPGYQK 207
++ C N++G F C +CP Y++
Sbjct: 538 INETCFNIQGGFRCLAFECPENYRR 562
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 183 bits (464), Expect = 4e-46
Identities = 108/339 (31%), Positives = 160/339 (47%), Gaps = 17/339 (5%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY+ P RQ C DIDEC I+ C +C N G Y C ++ + + +
Sbjct: 1227 CNPGYQATPDRQGCTDIDECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDGRSCADI 1284
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-QTGRNNFVIRRNPADPQ 147
E G + L GF+AS ++ + N+ + +
Sbjct: 1285 DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENT 1344
Query: 148 RIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
+ S C GY + C D+DEC G HNC C+N+ GSF C C G+
Sbjct: 1345 K----GSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400
Query: 207 KRGEQCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASN 262
G +C+D+DEC+ + + +CVNTPGS+ C CS GF + +TC D++EC + N
Sbjct: 1401 GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENIN 1458
Query: 263 QCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
C QC N+ G++ C+C G+ +SD +C+DIDEC + C N PG F C+C
Sbjct: 1459 LCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICD 1518
Query: 322 QGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
GY++ R+ C DI+EC C + +C N G + C
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINC-VNGLCVNTPGRYEC 1556
Score = 175 bits (444), Expect = 7e-44
Identities = 104/342 (30%), Positives = 147/342 (42%), Gaps = 61/342 (17%)
Query: 43 KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVV 102
+DIDEC ++P+ C G +C+N G + C K T GTS
Sbjct: 2448 RDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGY-----------TTDISGTSCIDLDEC 2495
Query: 103 AASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAG 162
+ S N++ + S++ C G
Sbjct: 2496 SQSPKPC--------------------------NYICKNTEG---------SYQCSCPRG 2520
Query: 163 YE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDEC-TI 220
Y Q + C+D+DEC HNC+ +C+N G F C+CPPG+ + C+D +EC +
Sbjct: 2521 YVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQ 2578
Query: 221 PPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQ 278
P C + C NTPGSF C+C GF L A C D++ECD +++C C NILG + C
Sbjct: 2579 PSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCG 2638
Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINE 337
C QGY C D +EC + C N G + C CP G+ + S C D+NE
Sbjct: 2639 CPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNE 2698
Query: 338 CETT-NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
C ++ N C C N GG+ C C Y + CV
Sbjct: 2699 CSSSKNPCNYG--CSNTEGGYLC----GCPPGYYRVGQGHCV 2734
Score = 172 bits (436), Expect = 6e-43
Identities = 113/390 (28%), Positives = 174/390 (44%), Gaps = 51/390 (13%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGY-------LCLPKTAQIIVNNEQPQQETQ----- 89
C+D++EC++ P C G +CVN G + L L T ++ ++ Q +
Sbjct: 953 CEDVNECEVFPGVCPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDE 1011
Query: 90 -----PAEGTSGATTGVVAASSMATSGVLP-------------GGGFVASAAAVAGPEMQ 131
P + A V A+ P G GF + G
Sbjct: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFY 1071
Query: 132 TGRNNFVIRRNPADPQRIPSN-PSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQV 189
N + + S + +C +G+ E C DIDEC C + +
Sbjct: 1072 KDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSG-I 1130
Query: 190 CINLRGSFACQCPPGYQK---RGEQCVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQ 244
C+N GSF C+C GY+ + C+DIDEC P + CVNT GSF C C G +
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
Query: 245 LAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
L+ + CVDINEC S+ + +C N++G++ C CN GY+ + DR C DIDEC +
Sbjct: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGFRCYP 361
C QC N G + C C +GY ++ R+C DI+ECE + + C N G +RC
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCL- 1309
Query: 362 RNPCQDPYILTPENR-CV----CPVSNAMC 386
C D ++ + + + C+ C +++ +C
Sbjct: 1310 ---CYDGFMASMDMKTCIDVNECDLNSNIC 1336
Score = 172 bits (436), Expect = 6e-43
Identities = 112/361 (31%), Positives = 164/361 (45%), Gaps = 58/361 (16%)
Query: 32 GYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPA 91
G+ +D + DIDEC +P C G+ C+N G + C T
Sbjct: 1796 GFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSFRCECPT----------------- 1837
Query: 92 EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPS 151
GF + + ++ N + + AD P
Sbjct: 1838 -------------------------GFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
Query: 152 NPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ 211
S+R +CAAG++ S + C D +EC + C + +C++L+GS+ C C G++ +Q
Sbjct: 1873 --SYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQ 1929
Query: 212 --CVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA--SNQCAQ- 266
C+D+DEC P + C NT GS+ C C PGF+L NN C+DI+EC + C
Sbjct: 1930 TMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNG 1988
Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQ 325
+C+N +GSF C CN+GYEL+ D NC D +EC C C N G F C+CP GY+
Sbjct: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE 2048
Query: 326 VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM 385
V+S C DINEC+ C N GGF+C C ++L+ R +
Sbjct: 2049 -VKSENCIDINECDEDPNICLFGSCTNTPGGFQCL----CPPGFVLSDNGRRCFDTRQSF 2103
Query: 386 C 386
C
Sbjct: 2104 C 2104
Score = 169 bits (427), Expect = 7e-42
Identities = 111/353 (31%), Positives = 154/353 (43%), Gaps = 38/353 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLP----KTAQIIVNNEQ 83
+C G+ D + C DIDEC I PD C G+ CVN G + C ++ +++ N
Sbjct: 1099 RCNSGFALDMEERNCTDIDECRISPDLCGSGI-CVNTPGSFECECFEGYESGFMMMKNCM 1157
Query: 84 PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
E + T V S L G E+ R + V
Sbjct: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPL-------------GHELSPSREDCVDINEC 1204
Query: 144 ADPQRIPSNP-------SHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRG 195
+ + N +++ C GY+ + + C DIDEC C D C N G
Sbjct: 1205 SLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC--DTQCTNSEG 1262
Query: 196 SFACQCPPGY--QKRGEQCVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYT 251
S+ C C GY G C DIDEC P C +C N PG + C C GF + + T
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322
Query: 252 CVDINECDA-SNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-- 307
C+D+NECD SN C +C N GSFIC C GY + C D+DEC ++ C
Sbjct: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHA 1382
Query: 308 QCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRC 359
C+N PG F C C +G+ + C D++EC T++C + C N G +RC
Sbjct: 1383 SCLNIPGSFKCSCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRC 1434
Score = 163 bits (413), Expect = 3e-40
Identities = 118/388 (30%), Positives = 162/388 (41%), Gaps = 63/388 (16%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACK-----------------------GGMKCVNH 64
+C G++ Q+C+DIDEC I+P C+ G +C++
Sbjct: 302 RCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQ 361
Query: 65 YGGYLCLPKTAQIIVNNEQPQQET------QPAE----GTSGATTGVVAASS---MATSG 111
G +C E P + T +P GT V + + G
Sbjct: 362 RTG-MCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG 420
Query: 112 VLPGGGFVASAAAVAGPEMQTGRNNFVIRRN-----PADPQRIPSNPSHRIQCAAGYEQS 166
LP GG SA + G TG N F N P IP + G
Sbjct: 421 -LPMGGIPGSAGSRPGG---TGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGV 476
Query: 167 EHN-----------VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY-QKRGEQCVD 214
+ Q ID C + C + CI S+ C+C GY Q C+D
Sbjct: 477 GAGGQGPIITGLTILNQTIDICKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCID 535
Query: 215 IDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNIL 272
+DECT P + CVNTPGS+YC+C GFQ C+DI+EC + + +C N
Sbjct: 536 VDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD 595
Query: 273 GSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRT 331
GSF C CN G+EL++D NC D DEC T++ C+NE G F C+C G+ + R
Sbjct: 596 GSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRY 655
Query: 332 CQDINECETTNECREDEMCWNYHGGFRC 359
C D++EC+T C C N G FRC
Sbjct: 656 CTDVDECQTPGICMNGH-CINSEGSFRC 682
Score = 162 bits (411), Expect = 5e-40
Identities = 105/311 (33%), Positives = 141/311 (45%), Gaps = 27/311 (8%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------PKTAQII 78
C++GY P + C DIDEC+ PD C GG +C N G Y CL KT I
Sbjct: 1268 CSEGYALMPDGRSCADIDECENNPDICDGG-QCTNIPGEYRCLCYDGFMASMDMKTC--I 1324
Query: 79 VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
NE G T G V G + E + G +N
Sbjct: 1325 DVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKG-----TTGCTDVDECEIGAHNCD 1379
Query: 139 IRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFA 198
+ A IP S + C G+ + C D+DEC+ GTH C + C+N GS+
Sbjct: 1380 MH---ASCLNIPG--SFKCSCREGWIGNGIK-CIDLDECSNGTHQCSINAQCVNTPGSYR 1433
Query: 199 CQCPPGYQKRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
C C G+ G C D+DEC I + +C+N PG++ C+C GF A+++ +C DI+
Sbjct: 1434 CACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1493
Query: 257 ECDASNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
EC N C C N+ G F C C+ GYEL NC DIDEC CVN PG+
Sbjct: 1494 ECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGR 1553
Query: 316 FSCMCPQGYQV 326
+ C CP +Q+
Sbjct: 1554 YECNCPPDFQL 1564
Score = 159 bits (403), Expect = 4e-39
Identities = 86/217 (39%), Positives = 117/217 (53%), Gaps = 12/217 (5%)
Query: 154 SHRIQCAAGYEQSEHNV--CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
S +C GYE + C DIDEC CR C+N GSF C CP G++
Sbjct: 1137 SFECECFEGYESGFMMMKNCMDIDECERNPLLCRGG-TCVNTEGSFQCDCPLGHELSPSR 1195
Query: 210 EQCVDIDECTIPP-YCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQ 266
E CVDI+EC++ C +CVN G++ C C+PG+Q + C DI+EC N C
Sbjct: 1196 EDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDT 1255
Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQ 325
QC N GS+ C C++GY L D +C DIDEC + +C QC N PG++ C+C G+
Sbjct: 1256 QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFM 1315
Query: 326 V-VRSRTCQDINECE-TTNECREDEMCWNYHGGFRCY 360
+ +TC D+NEC+ +N C E C N G F C+
Sbjct: 1316 ASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFICH 1351
Score = 154 bits (390), Expect = 1e-37
Identities = 115/365 (31%), Positives = 163/365 (44%), Gaps = 44/365 (12%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVN---NEQP 84
+C GY + C+DIDEC P C G C N G Y C+ + VN N
Sbjct: 1676 ECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCICPPEYMQVNGGHNCMD 1734
Query: 85 QQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPA 144
+++ +G T LP V + N P
Sbjct: 1735 MRKSFCYRSYNGTT----------CENELPFN--VTKRMCCCTYNVGKAWN------KPC 1776
Query: 145 DPQRIPSNPSHRIQCA--AGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
+P P + C G+ H DIDEC C A+ VCIN GSF C+C
Sbjct: 1777 EPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC-ANGVCINQIGSFRCEC 1835
Query: 202 PPG--YQKRGEQCVDIDECTIPPYCHQR---CVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
P G Y C DIDEC+ QR C+N+PGS+ C+C+ GF+L+ N CVD N
Sbjct: 1836 PTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRN 1894
Query: 257 EC-DASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEP 313
EC + N C+ C ++ GS+ C C+ G++ S D+ C D+DEC + C C N
Sbjct: 1895 ECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTV 1952
Query: 314 GKFSCMCPQGYQVVRSRTCQDINECET--TNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
G ++C+C G+++ + C DI+EC + CR C+N G F+C C + Y L
Sbjct: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGR-CFNEIGSFKCL----CNEGYEL 2007
Query: 372 TPENR 376
TP+ +
Sbjct: 2008 TPDGK 2012
Score = 153 bits (387), Expect = 3e-37
Identities = 113/352 (32%), Positives = 151/352 (42%), Gaps = 52/352 (14%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GYE + C DI+ECD P+ C G C N GG+ CL ++ +N + +T
Sbjct: 2043 CPPGYEVKS--ENCIDINECDEDPNICLFG-SCTNTPGGFQCLCPPGFVLSDNGRRCFDT 2099
Query: 89 QPA-------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRR 141
+ + G + +PG G+
Sbjct: 2100 RQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGW----------------------- 2136
Query: 142 NPADPQRI-PSNPSHRIQ--CAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
DP + P + Q C G+ S H+ +D++EC C Q CIN GS
Sbjct: 2137 --GDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGS 2193
Query: 197 FACQCPPGYQK--RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
F C+CP GY G +CVD DEC+I C + C N GSF C C+ GF+ C
Sbjct: 2194 FRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNCE 2252
Query: 254 DINECDASNQ--CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ---YQ 308
DINEC A N CA +C N GS+ C C GY L D+ C+D+DEC + C+
Sbjct: 2253 DINEC-AQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
Query: 309 CVNEPGKFSCMCPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
C N G F C+CP G + C D NEC T E+ C N G +RC
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRC 2363
Score = 148 bits (373), Expect = 1e-35
Identities = 85/242 (35%), Positives = 118/242 (48%), Gaps = 9/242 (3%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
IP+ S+R +C GY+Q + C D+DECT+ N + C+N GS+ C+C G+Q+
Sbjct: 511 IPTVSSYRCECNMGYKQDANGDCIDVDECTS---NPCTNGDCVNTPGSYYCKCHAGFQRT 567
Query: 209 G--EQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
+ C+DIDEC + RCVNT GSF C C+ GF+L + CVD +EC +N C
Sbjct: 568 PTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMC 627
Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
C N GSF C C G+ L+ + C D+DEC+T C+N G F C CP G
Sbjct: 628 LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPG 687
Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVS 382
V + R C D + T + +C G C +P E CP
Sbjct: 688 LAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747
Query: 383 NA 384
N+
Sbjct: 748 NS 749
Score = 141 bits (356), Expect = 1e-33
Identities = 109/370 (29%), Positives = 146/370 (39%), Gaps = 71/370 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ P + C D+DEC P C G C+N G + C +
Sbjct: 643 CKPGFVLAPNGRYCTDVDECQ-TPGICMNG-HCINSEGSFRC----------------DC 684
Query: 89 QP--AEGTSGATTGVVAASSMATSGVLPG-------GGFVASAAAVAGPEMQTGRNNFVI 139
P A G G S G+ G G S A P+ G
Sbjct: 685 PPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE----- 739
Query: 140 RRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
P P ++ C++G + +DI+EC C A+ +C NLRGS+ C
Sbjct: 740 ---PCQPCPAKNSAEFHGLCSSGVGITVDG--RDINECALDPDIC-ANGICENLRGSYRC 793
Query: 200 QCPPGYQK--RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDI 255
C GY+ G C+DIDEC + C NTPGS+ C C PG+ TC DI
Sbjct: 794 NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
Query: 256 NECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYL------CQYQ 308
NEC+ SN C C N LGSF C+C+ G +LSS L C ID + + +L C+
Sbjct: 854 NECE-SNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC--IDSLKGTCWLNIQDSRCEVN 910
Query: 309 CVNEPGKFSC-------------------MCPQGYQVVRSRTCQDINECETTNECREDEM 349
K C CP+G ++ TC+D+NECE +
Sbjct: 911 INGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGR 970
Query: 350 CWNYHGGFRC 359
C N G F C
Sbjct: 971 CVNSKGSFHC 980
Score = 136 bits (343), Expect = 4e-32
Identities = 99/348 (28%), Positives = 145/348 (41%), Gaps = 46/348 (13%)
Query: 29 CTDGYEWDPVRQQCKDIDEC-DIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIV 79
C GY ++ CKD+DEC + + D GM C N G ++C+ P +
Sbjct: 2279 CPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVD 2338
Query: 80 NNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVI 139
NE T+P +G ++ + + GF +S++ G E R
Sbjct: 2339 ENEC---RTKPGICENGRCVNIIGSYRCECNE-----GFQSSSS---GTECLDNRQGLCF 2387
Query: 140 RRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT----HNCRADQVCINLRG 195
+ +Q S N+ + C G H C + +
Sbjct: 2388 --------------AEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433
Query: 196 SFACQCPPGYQKRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
C PGY G DIDEC + P + +C+NT GSF C C G+ + +C+
Sbjct: 2434 KKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490
Query: 254 DINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE 312
D++EC S + C C N GS+ C C +GY L D C+D+DEC+T + CQ+ CVN
Sbjct: 2491 DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT 2550
Query: 313 PGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
G F+C CP G+ C D NEC + C +C N G F C
Sbjct: 2551 LGGFTCKCPPGF-TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC 2597
Score = 133 bits (335), Expect = 3e-31
Identities = 109/379 (28%), Positives = 147/379 (38%), Gaps = 61/379 (16%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY C D+DEC+I C C+N G + C + I N +
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW-IGNGIKCIDLD 1410
Query: 89 QPAEGTSGATTGVVAASS-----MATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
+ + GT + ++ A S G GF S + N +
Sbjct: 1411 ECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCL---- 1466
Query: 144 ADPQRIPSNPSHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
+P ++R +C G+ S+ CQDIDEC+ N C NL G F C C
Sbjct: 1467 ----NVPG--AYRCECEMGFTPASDSRSCQDIDECS--FQNICVFGTCNNLPGMFHCICD 1518
Query: 203 PGYQ--KRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVD--INE 257
GY+ + G C DIDEC P C + CVNTPG + C C P FQL CVD +
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGN 1578
Query: 258 C--------DASNQC---------AQQCYNILGS------------------FICQCNQG 282
C D S C C LG +C +G
Sbjct: 1579 CYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEG 1638
Query: 283 YELSSDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECET 340
+ + + EDIDEC+ LCQ C+N G F C CPQGY + +R C+DI+EC
Sbjct: 1639 FRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFA 1698
Query: 341 TNECREDEMCWNYHGGFRC 359
C+N G + C
Sbjct: 1699 HPGVCGPGTCYNTLGNYTC 1717
Score = 132 bits (333), Expect = 5e-31
Identities = 116/429 (27%), Positives = 171/429 (39%), Gaps = 81/429 (18%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GYE D + C DIDEC + C G+ C N G Y C + + ++
Sbjct: 795 CNSGYEPDASGRNCIDIDECLVNRLLCDNGL-CRNTPGSYSCTCPPGYVFRTETETCEDI 853
Query: 89 QPAEGT---SGATTGVVAA--------SSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
E +GA + + S ++++G++ + S +Q R
Sbjct: 854 NECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLI----CIDSLKGTCWLNIQDSRCEV 909
Query: 138 VIRRNPADPQRIPS------NPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRAD 187
I + + +P R + C G + + C+D++EC C
Sbjct: 910 NINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNG 969
Query: 188 QVCINLRGSFACQCPPGY--QKRGEQCVDI--DECTIPPYCHQRCVN-TPGSFY---CQC 239
+ C+N +GSF C+CP G G C+DI ++C + + C++ PG F C C
Sbjct: 970 R-CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLK-WDEDECIHPVPGKFRMDACCC 1027
Query: 240 SPGFQLAANNYTCV-------------------------------DINECDA-SNQCAQ- 266
+ G C DINEC A C
Sbjct: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087
Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQ 325
+C N +GSF C+CN G+ L + NC DIDECR S LC CVN PG F C C +GY+
Sbjct: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147
Query: 326 --VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV---- 378
+ + C DI+ECE C N G F+C C + L+P CV
Sbjct: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQC----DCPLGHELSPSREDCVDINE 1203
Query: 379 CPVSNAMCR 387
C +S+ +CR
Sbjct: 1204 CSLSDNLCR 1212
Score = 129 bits (323), Expect = 8e-30
Identities = 126/441 (28%), Positives = 173/441 (39%), Gaps = 90/441 (20%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVNN 81
C DGYE D C DIDEC P C G+ CVN G Y C L T V+N
Sbjct: 1517 CDDGYELDRTGGNCTDIDEC-ADPINCVNGL-CVNTPGRYECNCPPDFQLNPTGVGCVDN 1574
Query: 82 EQPQQETQ---PAEGTSGATTGV---VAASSMATSGVLPGGGFVASAAAVAGPEMQT--- 132
+ +G+ T + V+ SS S G + V E T
Sbjct: 1575 RVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCP 1634
Query: 133 GRNNF------VIRRNPADPQRIP----------SNPSHRIQCAAGYEQSEHN-VCQDID 175
G F +I + + Q +P + S + +C GY SE +C+DID
Sbjct: 1635 GGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQR-----C 228
EC A C C N G++ C CPP Y + G C+D+ + +C++ C
Sbjct: 1695 ECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKS----FCYRSYNGTTC 1749
Query: 229 VN-----------------------------TPGSF----YCQCSPGFQLAANNYTCVDI 255
N TPG+ C PGF + VDI
Sbjct: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809
Query: 256 NEC-DASNQCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ--YQCVN 311
+EC + CA C N +GSF C+C G+ + L CEDIDEC LCQ C+N
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCIN 1869
Query: 312 EPGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRN---PCQD 367
PG + C C G+++ + C D NEC E N C +C + G ++C N QD
Sbjct: 1870 SPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG-LCVDLQGSYQCICHNGFKASQD 1928
Query: 368 PYILTPENRCV-CPVSNAMCR 387
+ + C P N C+
Sbjct: 1929 QTMCMDVDECERHPCGNGTCK 1949
Score = 127 bits (318), Expect = 3e-29
Identities = 106/373 (28%), Positives = 140/373 (37%), Gaps = 93/373 (24%)
Query: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
Y +C G++ P +Q C DIDEC CK G +CVN G + C+ +
Sbjct: 557 YCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNTDGSFQCICNAGFELT------ 609
Query: 86 QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
+G + ++M +G+
Sbjct: 610 -----TDGKNCVDHDECTTTNMCLNGMC-------------------------------- 632
Query: 146 PQRIPSNPSHRIQCAAGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
I + S + C G+ + + C D+DEC T + CIN GSF C CPPG
Sbjct: 633 ---INEDGSFKCICKPGFVLAPNGRYCTDVDECQ--TPGICMNGHCINSEGSFRCDCPPG 687
Query: 205 YQ--KRGEQCVDIDE---------------------------CTIPPY-----CHQRCVN 230
G CVD C P Y C
Sbjct: 688 LAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747
Query: 231 TPGSFYCQCSPGFQLAANNYTCVDINECDAS-NQCAQQ-CYNILGSFICQCNQGYELSSD 288
F+ CS G + + DINEC + CA C N+ GS+ C CN GYE +
Sbjct: 748 NSAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSGYEPDAS 804
Query: 289 RLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECRE 346
NC DIDEC + LC C N PG +SC CP GY + TC+DINECE +N C
Sbjct: 805 GRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE-SNPC-V 862
Query: 347 DEMCWNYHGGFRC 359
+ C N G F C
Sbjct: 863 NGACRNNLGSFNC 875
Score = 127 bits (318), Expect = 3e-29
Identities = 114/472 (24%), Positives = 171/472 (36%), Gaps = 116/472 (24%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C G+ ++ + C+DIDEC + C+ C+N G Y C + N
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR 1893
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ E + + G+ + + GF AS ++ R+P
Sbjct: 1894 NECLEIPNVCSHGL-CVDLQGSYQCICHNGFKASQDQTMCMDVDE------CERHPCGNG 1946
Query: 148 RIPSNP-SHRIQCAAGYEQSEHNVCQDIDECTA---------------GTHNCRADQ--- 188
+ S+ C G+E + +N C DIDEC++ G+ C ++
Sbjct: 1947 TCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYE 2006
Query: 189 ------------------------VCINLRGSFACQCPPGYQKRGEQCVDIDECTIPP-- 222
C NL GSF C CPPGY+ + E C+DI+EC P
Sbjct: 2007 LTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNI 2066
Query: 223 YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA-----SNQCA-QQCYNILGSFI 276
C NTPG F C C PGF L+ N C D + + +C+ + +N +
Sbjct: 2067 CLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC 2126
Query: 277 C--------------QCNQGYELSSDRL-------------NCEDIDECRTSSYLCQY-Q 308
C C + E++ L ED++EC S +C Q
Sbjct: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ 2186
Query: 309 CVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCY------- 360
C+N G F C CP GY + C D +EC N C + C N G F C
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIGSFECNCNEGFEP 2245
Query: 361 -PRNPCQD-------PYILT-------PENRCVCPVSNA------MCRELPQ 391
P C+D P + C CP+ A MC++L +
Sbjct: 2246 GPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDE 2297
Score = 105 bits (263), Expect = 7e-23
Identities = 73/244 (29%), Positives = 106/244 (43%), Gaps = 39/244 (15%)
Query: 154 SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ-- 211
S C G+E C+DI+EC C C+N GS+ C CP GY R +Q
Sbjct: 2234 SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKM 2291
Query: 212 CVDIDECTIPPY-CHQR---CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ- 266
C D+DEC + C R C N G+F C C PG + CVD NEC +
Sbjct: 2292 CKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICEN 2351
Query: 267 -QCYNILGSFICQCNQGYELSSDRLNCEDIDE-----------CRTSS----YLCQYQCV 310
+C NI+GS+ C+CN+G++ SS C D + C+ +S + + +C
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2411
Query: 311 NEPGK---FSC-MCPQGYQVVRSRTC----------QDINECETTNECREDEMCWNYHGG 356
+ G+ C +CP + C +DI+EC+ + C N G
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGS 2471
Query: 357 FRCY 360
FRC+
Sbjct: 2472 FRCF 2475
Score = 79.0 bits (193), Expect = 9e-15
Identities = 47/140 (33%), Positives = 70/140 (50%), Gaps = 11/140 (7%)
Query: 153 PSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
P+ C G+ + CQD+DEC A C+ CIN GSF C+CP G++ +
Sbjct: 255 PAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGN-CINTVGSFECRCPAGHKQSETT 313
Query: 210 EQCVDIDECT-IPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVD--INECDA---SN 262
++C DIDEC+ IP C C NT GS++C C G+ + + C+D C + +
Sbjct: 314 QKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNG 373
Query: 263 QCAQQCYNILGSFICQCNQG 282
+CAQ+ + C C G
Sbjct: 374 RCAQELPGRMTKMQCCCEPG 393
Score = 74.7 bits (182), Expect = 2e-13
Identities = 44/120 (36%), Positives = 57/120 (47%), Gaps = 8/120 (6%)
Query: 212 CVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--Q 267
C D+DEC IP C C+NT GSF C+C G + + C DI+EC + +
Sbjct: 274 CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGE 333
Query: 268 CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE-PG---KFSCMCPQG 323
C N +GS+ C C +GY S+D C D S L +C E PG K C C G
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 70.1 bits (170), Expect = 4e-12
Identities = 34/89 (38%), Positives = 46/89 (51%), Gaps = 3/89 (3%)
Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDID 296
C GF C D++EC A Q C N +GSF C+C G++ S CEDID
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 320
Query: 297 ECRTSSYLCQY-QCVNEPGKFSCMCPQGY 324
EC +C+ +C N G + C+CP+GY
Sbjct: 321 ECSIIPGICETGECSNTVGSYFCVCPRGY 349
Score = 59.7 bits (143), Expect = 6e-09
Identities = 57/241 (23%), Positives = 83/241 (34%), Gaps = 72/241 (29%)
Query: 199 CQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN--TPGSFYCQCSPGF------QLAANNY 250
C C G I +C++ RC+N T +CQC G+ Q N
Sbjct: 130 CTCSSGQISSTCGSKSIQQCSV------RCMNGGTCADDHCQCQKGYIGTYCGQPVCEN- 182
Query: 251 TCVDINECDASNQCA-------------------------QQCYNILGSFICQ------- 278
C + C N+CA Q C L +C
Sbjct: 183 GCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCAT 242
Query: 279 ------------------CNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCM 319
C +G+ + C+D+DEC+ +CQ C+N G F C
Sbjct: 243 IGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECR 302
Query: 320 CPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-TPENRC 377
CP G+ Q ++ C+DI+EC E C N G + C C Y+ T +RC
Sbjct: 303 CPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV----CPRGYVTSTDGSRC 358
Query: 378 V 378
+
Sbjct: 359 I 359
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/188 (24%), Positives = 71/188 (37%), Gaps = 53/188 (28%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C G+ D C+D+DECD C+ G C N GGY C Q + + Q Q
Sbjct: 2598 ECQRGFSLDATGLNCEDVDECD-GNHRCQHG--CQNILGGYRC--GCPQGYIQHYQWNQC 2652
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
E ++ G +AS T G
Sbjct: 2653 VDENECSNPNACG--SASCYNTLG------------------------------------ 2674
Query: 148 RIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
S++ C +G+ + + C D++EC++ + C + C N G + C CPPGY
Sbjct: 2675 ------SYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLCGCPPGYY 2726
Query: 207 KRGE-QCV 213
+ G+ CV
Sbjct: 2727 RVGQGHCV 2734
Score = 37.7 bits (86), Expect = 0.024
Identities = 13/29 (44%), Positives = 19/29 (65%), Gaps = 1/29 (3%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLC 70
C+D+DEC +P C+GG C+N G + C
Sbjct: 274 CQDVDECQAIPGICQGG-NCINTVGSFEC 301
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 182 bits (461), Expect = 8e-46
Identities = 121/394 (30%), Positives = 178/394 (45%), Gaps = 57/394 (14%)
Query: 41 QCKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVN--------NEQPQ 85
QC+DIDEC++ P CK G+ CVN G + C L T +I ++ + +
Sbjct: 907 QCEDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDE 965
Query: 86 QETQPAEG---------TSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+ T P G + GA G A E+ G+
Sbjct: 966 ECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPF 1025
Query: 137 FVIRRNPADPQRIPSNPSH----------RIQCAAGYE-QSEHNVCQDIDECTAGTHNCR 185
F ++ + + IPS +H + +C +G+ SE C DIDEC C
Sbjct: 1026 F---KDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCG 1082
Query: 186 ADQVCINLRGSFACQCPPGYQK---RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCS 240
Q C+N G F C+C GY+ + C+DIDEC P + C NT GS+ C+C
Sbjct: 1083 RGQ-CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECP 1141
Query: 241 PGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDEC 298
PG QL+ N C+DINEC+ S +C N++G + C CN GY + DRL C DIDEC
Sbjct: 1142 PGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC 1201
Query: 299 RTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGF 357
+ C+ C N G + C C G+ ++ R+C DI+ECE + C N G +
Sbjct: 1202 SIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEY 1261
Query: 358 RCYPRNPCQDPYILTPENR-CV----CPVSNAMC 386
RC C D ++ + + + CV C ++ +C
Sbjct: 1262 RCL----CYDGFMASEDMKTCVDVNECDLNPNIC 1291
Score = 174 bits (440), Expect = 2e-43
Identities = 106/340 (31%), Positives = 148/340 (43%), Gaps = 59/340 (17%)
Query: 44 DIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVA 103
DIDEC ++ D C+ G +CVN G Y C+ KT T GTS
Sbjct: 2402 DIDECKVIHDVCRNG-ECVNDRGSYHCICKTGY-----------TPDITGTSCVDLNECN 2449
Query: 104 ASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGY 163
+ NF+ + S++ C GY
Sbjct: 2450 QAPKPC--------------------------NFICKNTEG---------SYQCSCPKGY 2474
Query: 164 E-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIP- 221
Q + C+D+DEC HNC+ +C+N G F C+CPPG+ + C+D +ECT
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDI 2532
Query: 222 PYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQC 279
C + C NTPGSF C+C GF L +C D++EC+ +++C C NI+G + C C
Sbjct: 2533 NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSC 2592
Query: 280 NQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINEC 338
QGY C D +EC ++ C N G + CMCP G+Q + S CQDINEC
Sbjct: 2593 PQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINEC 2652
Query: 339 ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
+ + C N GG+ C C Y + CV
Sbjct: 2653 GSA-QAPCSYGCSNTEGGYLC----GCPPGYFRIGQGHCV 2687
Score = 171 bits (434), Expect = 1e-42
Identities = 114/355 (32%), Positives = 154/355 (43%), Gaps = 25/355 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY P R C DIDEC I+ C+ C N G Y C + ++ +++ +
Sbjct: 1182 CNPGYHSTPDRLFCVDIDECSIMNGGCE--TFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP---AD 145
E G + L GF+AS +M+T + NP
Sbjct: 1240 DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASE------DMKTCVDVNECDLNPNICLS 1293
Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
+ S C GY + C DI+EC G HNC VC N GSF C C PG
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPG 1353
Query: 205 YQKRGEQCVDIDECTIPPYC---HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
+ G +C D+DEC+ + H C NT GS+ C C G+ + +TC D++EC +
Sbjct: 1354 WIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLDECSEN 1411
Query: 262 -NQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCM 319
N C QC N G + C+C+ G+ S+D CEDIDEC + C N PG F C
Sbjct: 1412 LNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCE 1471
Query: 320 CPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP 373
C GY++ RS C D+NEC C C N G + C C + L P
Sbjct: 1472 CEIGYELDRSGGNCTDVNECLDPTTCISGN-CVNTPGSYIC----DCPPDFELNP 1521
Score = 164 bits (415), Expect = 2e-40
Identities = 122/403 (30%), Positives = 171/403 (42%), Gaps = 53/403 (13%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
QC +GYE P + C DI+EC + P C G C N G Y C+ + NE+ +
Sbjct: 1957 QCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGYSL-QNEKCEDI 2014
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ E G + + + + P G ++S+ G Q R ++ +
Sbjct: 2015 DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSS----GRRCQDLRMSYCYAKFEGGKC 2070
Query: 148 RIPSNPSHRIQ-----------------CAAGYEQSEHNVCQ--------------DIDE 176
P + +H Q C +++ +C D+DE
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130
Query: 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTPGSF 235
C C+ Q CIN GS+ C+CP GY G +CVD DEC++ C + C N G F
Sbjct: 2131 CKE-PDVCKHGQ-CINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGF 2188
Query: 236 YCQCSPGFQLAANNYTCVDINECDASNQ--CAQQCYNILGSFICQCNQGYELSSDRLNCE 293
C C GF+ TC DINEC A N CA +C N GS+ C+C GY L DR C+
Sbjct: 2189 ECTCEEGFE-PGPMMTCEDINEC-AQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246
Query: 294 DIDECRTSSYLC---QYQCVNEPGKFSCMCPQGYQ-VVRSRTCQDINECETTNECREDEM 349
D DEC + C Q +C N G + C+C GYQ C D NEC+T E+
Sbjct: 2247 DEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR 2306
Query: 350 CWNYHGGFRC-----YPRNPCQDPYILTPENRCVCPVSNAMCR 387
C N G + C + +P QD + E C V MC+
Sbjct: 2307 CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQ 2349
Score = 161 bits (408), Expect = 1e-39
Identities = 89/213 (41%), Positives = 119/213 (55%), Gaps = 9/213 (4%)
Query: 154 SHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE-Q 211
S R +C G+ ++ VC+DIDEC G C+ + CIN GS+ C C PGY+ Q
Sbjct: 1788 SFRCECPVGFFYNDKLLVCEDIDECQNGPV-CQRNAECINTAGSYRCDCKPGYRFTSTGQ 1846
Query: 212 CVDIDECT-IPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCY 269
C D +EC IP C H +C++T GSFYC C GF+ + C+DINEC+ C
Sbjct: 1847 CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCR 1906
Query: 270 NILGSFICQCNQGYELSSDRLNCEDIDECRT-SSYLCQY-QCVNEPGKFSCMCPQGYQVV 327
N +GSF C+CN G+ LS + +C D+DEC + + LC+ QC+N G F C C +GY+V
Sbjct: 1907 NTIGSFNCRCNHGFILSHNN-DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVA 1965
Query: 328 -RSRTCQDINECETTNECREDEMCWNYHGGFRC 359
RTC DINEC C N G +RC
Sbjct: 1966 PDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC 1998
Score = 159 bits (402), Expect = 5e-39
Identities = 113/371 (30%), Positives = 157/371 (42%), Gaps = 44/371 (11%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGG-----------------------MKCVNH 64
+C G++ + V Q+C+DIDEC +P C+GG +C++
Sbjct: 272 KCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Query: 65 YGGYLCLPKTAQIIVNNEQPQQETQP---AEGTSGATTGVVAASSMATSGVLPGGGFVAS 121
GY C +N+ PQ T+ + + GV A M + S
Sbjct: 332 RPGY-CYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCS 390
Query: 122 AAAVAG-----PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDI-- 174
V P G V+ P P P P R Y E +
Sbjct: 391 VPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPG-PQIPVPRPPVEYLYPSREPPRVLPVNV 449
Query: 175 -DECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQRCVNT 231
D C + C+ + CI GS C+C G+Q RGE C+D+DEC P C+N
Sbjct: 450 TDYCQLVRYLCQNGR-CIPTPGSCRCECNKGFQLDLRGE-CIDVDECEKNPCAGGECINN 507
Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDR 289
GS+ CQC G+Q C DI+EC + + +C N GSF C CN G+ ++ D
Sbjct: 508 QGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDG 567
Query: 290 LNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDE 348
NCED+DEC + C+NE G F C+C G+Q+ R C+DINECET C
Sbjct: 568 KNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR 627
Query: 349 MCWNYHGGFRC 359
C N G +RC
Sbjct: 628 -CVNTDGSYRC 637
Score = 155 bits (393), Expect = 6e-38
Identities = 101/322 (31%), Positives = 141/322 (43%), Gaps = 32/322 (9%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------PKTAQII 78
C G+ P ++ C DIDEC+ P+ C GG +C N G Y CL KT +
Sbjct: 1223 CQPGFALMPDQRSCTDIDECEDNPNICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDV 1281
Query: 79 VNNEQPQQETQPAEGTSGATTG-VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
NE GT T G + M SG G T N
Sbjct: 1282 --NECDLNPNICLSGTCENTKGSFICHCDMGYSGK-------------KGKTGCTDINEC 1326
Query: 138 VIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGS 196
I + + +N + +C+ + C D+DEC+ GTH C C N GS
Sbjct: 1327 EIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGS 1386
Query: 197 FACQCPPGYQKRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVD 254
+ C C GY G C D+DEC+ + + +C+N PG + C+C GF +A+ C D
Sbjct: 1387 YRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED 1446
Query: 255 INECDASNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEP 313
I+EC N C C+N+ G F C+C GYEL NC D++EC + CVN P
Sbjct: 1447 IDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTP 1506
Query: 314 GKFSCMCPQGYQVVRSRT-CQD 334
G + C CP +++ +R C D
Sbjct: 1507 GSYICDCPPDFELNPTRVGCVD 1528
Score = 153 bits (387), Expect = 3e-37
Identities = 109/354 (30%), Positives = 149/354 (42%), Gaps = 66/354 (18%)
Query: 28 QCTDGYEWD-PVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
+C +GYE + + C DIDEC P C+GG+ C N G Y C
Sbjct: 1096 KCDEGYESGFMMMKNCMDIDECQRDPLLCRGGV-CHNTEGSYRC---------------- 1138
Query: 87 ETQPAEGTSGATTGVVAASSMATSGVL-PGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
E P S + + + S L P G V N +
Sbjct: 1139 ECPPGHQLSPNISACIDINECELSAHLCPNGRCV----------------NLI------- 1175
Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
++ C GY + + C DIDEC+ C + C N GS+ C C PG
Sbjct: 1176 -------GKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC--ETFCTNSEGSYECSCQPG 1226
Query: 205 YQKRGEQ--CVDIDEC-TIPPYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA 260
+ +Q C DIDEC P C +C N PG + C C GF + + TCVD+NECD
Sbjct: 1227 FALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDL 1286
Query: 261 S-NQC-AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKF 316
+ N C + C N GSFIC C+ GY + C DI+EC ++ C C N G F
Sbjct: 1287 NPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSF 1346
Query: 317 SCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPY 369
C C G+ + C D++EC T+ C + C N G +RC C++ Y
Sbjct: 1347 KCSCSPGW-IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCL----CKEGY 1395
Score = 139 bits (350), Expect = 6e-33
Identities = 110/396 (27%), Positives = 158/396 (39%), Gaps = 51/396 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY + Q C D +EC +P+ C G +C++ G + CL T N+
Sbjct: 1835 CKPGYRFTSTGQ-CNDRNECQEIPNICSHG-QCIDTVGSFYCLCHTG--FKTNDDQTMCL 1890
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAA--AVAGPEMQTGRNNFVIRRNPADP 146
E A +++ + GF+ S + E +G N +
Sbjct: 1891 DINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLC-----RNG 1945
Query: 147 QRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
Q I + S + QC GYE + + C DI+EC C A C NL GS+ C CPPGY
Sbjct: 1946 QCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKC-APGTCQNLDGSYRCICPPGY 2004
Query: 206 QKRGEQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI-------- 255
+ E+C DIDEC P C NT GSF C C GF L+++ C D+
Sbjct: 2005 SLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAK 2064
Query: 256 ---NECD---ASNQCAQQCYNILGS-------------------FICQCNQGYELSSDRL 290
+C + N Q+C L IC G + D
Sbjct: 2065 FEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDD- 2123
Query: 291 NCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
+ D+DEC+ QC+N G + C CP GY ++ C D +EC N C + C
Sbjct: 2124 SAVDMDECKEPDVCKHGQCINTDGSYRCECPFGY-ILAGNECVDTDECSVGNPC-GNGTC 2181
Query: 351 WNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMC 386
N GGF C + ++T E+ C + +C
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLC 2217
Score = 139 bits (349), Expect = 8e-33
Identities = 85/238 (35%), Positives = 114/238 (47%), Gaps = 25/238 (10%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
IP+ S R +C G++ C D+DEC N A CIN +GS+ CQC GYQ
Sbjct: 466 IPTPGSCRCECNKGFQLDLRGECIDVDECEK---NPCAGGECINNQGSYTCQCRAGYQST 522
Query: 209 --GEQCVDIDECTIPP-YCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
+C DIDEC C+ RC+NT GSF+C C+ GF + + C D++EC N C
Sbjct: 523 LTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMC 582
Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
C N GSF C C G++L+SD C+DI+EC T +CVN G + C C G
Sbjct: 583 LNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPG 642
Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDP-YILTPENRCVC 379
V + R C D + T +GG Y R C P + ++ C C
Sbjct: 643 LAVGLDGRVCVDTHMRSTC------------YGG---YKRGQCIKPLFGAVTKSECCC 685
Score = 139 bits (349), Expect = 8e-33
Identities = 122/446 (27%), Positives = 177/446 (39%), Gaps = 87/446 (19%)
Query: 44 DIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVA 103
D+DEC PD CK G +C+N G Y C I+ NE + G T
Sbjct: 2127 DMDECK-EPDVCKHG-QCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGT---- 2180
Query: 104 ASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP--ADPQRIPSNPSHRIQCAA 161
V+ G GP M T + +NP + + + S+ +C
Sbjct: 2181 -----CKNVIGGFECTCEEGFEPGP-MMTCEDINECAQNPLLCAFRCVNTYGSYECKCPV 2234
Query: 162 GYE-QSEHNVCQDIDECTAGTHNCRADQV-CINLRGSFACQCPPGYQKR--GEQCVDIDE 217
GY + + +C+D DEC G H+C Q+ C NL G++ C C PGYQ+R GE CVD +E
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENE 2294
Query: 218 C-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE------------------ 257
C T P C RC+NT GS+ C+C+ GF + N C+D E
Sbjct: 2295 CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSN 2354
Query: 258 ----------CDASNQCAQQCY------NILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
CD C + +C +G+ N DIDEC+
Sbjct: 2355 RNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGF-----MTNGADIDECKVI 2409
Query: 302 SYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINEC-ETTNECREDEMCWNYHGGFR 358
+C+ +CVN+ G + C+C GY + +C D+NEC + C + +C N G ++
Sbjct: 2410 HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPC--NFICKNTEGSYQ 2467
Query: 359 CYPRNPCQDPYILTPENR------------------CVCPVSNAMCRELPQSIVYKYMSI 400
C C YIL + R CV + C+ P + S
Sbjct: 2468 C----SCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCK-CPPGFTQHHTSC 2522
Query: 401 RSDRSVPSDIFQIQATTIYANTINTF 426
+ SDI + I NT +F
Sbjct: 2523 IDNNECTSDINLCGSKGICQNTPGSF 2548
Score = 135 bits (339), Expect = 1e-31
Identities = 107/377 (28%), Positives = 157/377 (41%), Gaps = 64/377 (16%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQP-QQE 87
C +G+E P+ C+DI+EC P C +CVN YG Y C ++ + + + E
Sbjct: 2192 CEEGFEPGPM-MTCEDINECAQNPLLC--AFRCVNTYGSYECKCPVGYVLREDRRMCKDE 2248
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ--------TGRNNFVI 139
+ EG T + ++ + + + GP Q N
Sbjct: 2249 DECEEGKHDCTEKQMECKNL-----------IGTYMCICGPGYQRRPDGEGCVDENECQT 2297
Query: 140 RRNPADPQR-IPSNPSHRIQCAAGYEQS-EHNVCQDIDE-----------CTAGTHN--- 183
+ + R + + S+ +C G+ S + C D E C G+ N
Sbjct: 2298 KPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNP 2357
Query: 184 -CRADQVCINLRG--------------SFACQCP--PGYQKRGEQCVDIDEC-TIPPYCH 225
+++ C RG +F CP G+ G DIDEC I C
Sbjct: 2358 VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG---ADIDECKVIHDVCR 2414
Query: 226 Q-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQCAQQCYNILGSFICQCNQGY 283
CVN GS++C C G+ +CVD+NEC+ A C C N GS+ C C +GY
Sbjct: 2415 NGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGY 2474
Query: 284 ELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TN 342
L D +C+D+DEC T + CQ+ CVN G F+C CP G+ +C D NEC + N
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF-TQHHTSCIDNNECTSDIN 2533
Query: 343 ECREDEMCWNYHGGFRC 359
C +C N G F C
Sbjct: 2534 LCGSKGICQNTPGSFTC 2550
Score = 132 bits (331), Expect = 9e-31
Identities = 102/375 (27%), Positives = 149/375 (39%), Gaps = 53/375 (14%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY + C DI+EC+I C C N G + C I + +
Sbjct: 1307 CDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI-GDGIKCTDLD 1365
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
+ + GT + ++M + L G+ + + N + Q
Sbjct: 1366 ECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLC-----GNGQC 1420
Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ- 206
+ + +R +C G+ S + C+DIDEC+ N C NL G F C+C GY+
Sbjct: 1421 LNAPGGYRCECDMGFVPSADGKACEDIDECSLP--NICVFGTCHNLPGLFRCECEIGYEL 1478
Query: 207 -KRGEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE--C---- 258
+ G C D++EC P C CVNTPGS+ C C P F+L CVD C
Sbjct: 1479 DRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDI 1538
Query: 259 -----DASNQCAQQ---------CYNILGS------------------FICQCNQGYELS 286
+ C+ + C LG +C +G+ +
Sbjct: 1539 RPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPN 1598
Query: 287 SDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNEC 344
+ EDIDEC+ LCQ +C+N G F C CP GY + +R C D+NECET C
Sbjct: 1599 PITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGIC 1658
Query: 345 REDEMCWNYHGGFRC 359
C+N G + C
Sbjct: 1659 GPG-TCYNTVGNYTC 1672
Score = 130 bits (327), Expect = 3e-30
Identities = 101/360 (28%), Positives = 148/360 (41%), Gaps = 51/360 (14%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G++ + CKDI+EC+ P C G +CVN G Y C E
Sbjct: 598 CKPGFQLASDGRYCKDINECE-TPGICMNG-RCVNTDGSYRC----------------EC 639
Query: 89 QP--AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
P A G G S G G AV E + P P
Sbjct: 640 FPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGE-PCQP 698
Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
++ ++ C++G + DI+EC C + +C NLRG++ C C GY+
Sbjct: 699 CPAQNSAEYQALCSSGPGMTSAG--SDINECALDPDIC-PNGICENLRGTYKCICNSGYE 755
Query: 207 --KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
G+ CVDI+EC + + +C NTPGSF C C GF + TC DI+EC++S
Sbjct: 756 VDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSP 815
Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCED----------ID---ECRTSSYLCQYQC 309
C N GSFIC+C+ L + C + ID E + + QC
Sbjct: 816 CINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQC 875
Query: 310 VNEPG----------KFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
+ G + +C +GY ++ C+DI+ECE ++ +C N G F+C
Sbjct: 876 CSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKC 935
Score = 115 bits (289), Expect = 7e-26
Identities = 111/418 (26%), Positives = 159/418 (38%), Gaps = 86/418 (20%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---------LPKTAQII 78
+C GYE D C D++EC + P C G CVN G Y+C + +
Sbjct: 1471 ECEIGYELDRSGGNCTDVNEC-LDPTTCISG-NCVNTPGSYICDCPPDFELNPTRVGCVD 1528
Query: 79 VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
+ + +P G +G T A S + G AS G T
Sbjct: 1529 TRSGNCYLDIRP-RGDNGDT---------ACSNEIGVGVSKASCCCSLGKAWGT------ 1572
Query: 139 IRRNPADPQRIPSNPSHRIQCAAGYEQSEHN----VCQDIDECTAGTHNCRADQVCINLR 194
P + + ++I C G E N + +DIDEC C+ + CIN
Sbjct: 1573 ----PCEMCPAVNTSEYKILCPGG-EGFRPNPITVILEDIDECQELPGLCQGGK-CINTF 1626
Query: 195 GSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYT 251
GSF C+CP GY + C D++EC P C C NT G++ C C P +
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNN 1686
Query: 252 CVDINE-------------CDAS---NQCAQQC---YNILGSFICQCNQGYELSSDRLNC 292
C+D+ CD N + C YNI ++ C Q S+D
Sbjct: 1687 CMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFAT 1746
Query: 293 ------------------EDIDECRTSSYLCQY-QCVNEPGKFSCMCPQG-YQVVRSRTC 332
DIDECR +C+ C+N G F C CP G + + C
Sbjct: 1747 LCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVC 1806
Query: 333 QDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELP 390
+DI+EC+ C+ + C N G +RC C+ Y T +C C+E+P
Sbjct: 1807 EDIDECQNGPVCQRNAECINTAGSYRC----DCKPGYRFTSTGQC---NDRNECQEIP 1857
Score = 97.8 bits (242), Expect = 2e-20
Identities = 85/333 (25%), Positives = 135/333 (40%), Gaps = 47/333 (14%)
Query: 25 TYT-QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ 83
+YT QC GY+ R +C+DIDEC C G +C+N G + C+ + + +
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG-RCINTDGSFHCVCNAGFHVTRDGK 568
Query: 84 PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
++ + G+ + + G +AS + +
Sbjct: 569 NCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICM---- 624
Query: 144 ADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDI---DECTAGTHN-----------CRADQ 188
+ + + ++ S+R +C G + VC D C G +++
Sbjct: 625 -NGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSEC 683
Query: 189 VCINLRGSFA--CQ-CP--------------PGYQKRGEQCVDIDECTI-PPYC-HQRCV 229
C + +F CQ CP PG G DI+EC + P C + C
Sbjct: 684 CCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGS---DINECALDPDICPNGICE 740
Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSS 287
N G++ C C+ G+++ + CVDINEC ++ QC N GSF+C C +G+
Sbjct: 741 NLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKP 800
Query: 288 DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC 320
D CEDIDEC +S + C N PG F C C
Sbjct: 801 DLKTCEDIDECESSPCI-NGVCKNSPGSFICEC 832
Score = 85.1 bits (209), Expect = 1e-16
Identities = 47/140 (33%), Positives = 70/140 (50%), Gaps = 11/140 (7%)
Query: 153 PSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
P+ C G+ + CQD+DEC A C+ CIN GSF C+CP G++ +
Sbjct: 225 PAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGN-CINTVGSFECKCPAGHKLNEVS 283
Query: 210 EQCVDIDEC-TIPPYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDIN-----ECDASN 262
++C DIDEC TIP C C NT S++C+C PGF + + C+D+ +
Sbjct: 284 QKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNG 343
Query: 263 QCAQQCYNILGSFICQCNQG 282
+C+ Q + C C+ G
Sbjct: 344 RCSNQLPQSITKMQCCCDAG 363
Score = 72.8 bits (177), Expect = 7e-13
Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 212 CVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--Q 267
C D+DEC IP C C+NT GSF C+C G +L + C DI+EC + +
Sbjct: 244 CQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGE 303
Query: 268 CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
C N + S+ C+C G+ S D C D+ + L +C N+ PQ +
Sbjct: 304 CTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQ-------LPQ--SIT 354
Query: 328 RSRTCQDINECETTNECREDEMC 350
+ + C D C + EMC
Sbjct: 355 KMQCCCDAGRCWSPGVTVAPEMC 377
Score = 68.2 bits (165), Expect = 2e-11
Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 4/101 (3%)
Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDID 296
C GF C D++EC A Q C N +GSF C+C G++L+ CEDID
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290
Query: 297 ECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVRSRT-CQDI 335
EC T +C+ +C N + C CP G+ T C D+
Sbjct: 291 ECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/265 (23%), Positives = 95/265 (35%), Gaps = 81/265 (30%)
Query: 199 CQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN--TPGSFYCQCSPGF------QLAANNY 250
C CP G I C I RC+N + +C C G+ Q +
Sbjct: 100 CTCPSGQIAPSCGSRSIQHCNI------RCMNGGSCSDDHCLCQKGYIGTHCGQPVCES- 152
Query: 251 TCVDINECDASNQCA----------------QQCYNILGSFICQ---------------- 278
C++ C A N+CA C+ ++ + +CQ
Sbjct: 153 GCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCAT 212
Query: 279 ------------------CNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCM 319
C +G+ + C+D+DEC+ LCQ C+N G F C
Sbjct: 213 VGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECK 272
Query: 320 CPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-- 376
CP G+++ S+ C+DI+EC T E C N + C C + +P+
Sbjct: 273 CPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFC----KCPPGFYTSPDGTRC 328
Query: 377 -------CVCPVSNAMC-RELPQSI 393
C ++N C +LPQSI
Sbjct: 329 IDVRPGYCYTALTNGRCSNQLPQSI 353
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/198 (26%), Positives = 73/198 (36%), Gaps = 54/198 (27%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQI 77
Q+T + T +C G+ D C+D+DEC+ C+ G C N GGY C Q
Sbjct: 2542 QNTPGSFT-CECQRGFSLDQTGSSCEDVDECE-GNHRCQHG--CQNIIGGYRC--SCPQG 2595
Query: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
+ + Q Q E S G AS T G
Sbjct: 2596 YLQHYQWNQCVDENECLSAHICG--GASCHNTLG-------------------------- 2627
Query: 138 VIRRNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGS 196
S++ C AG++ + + CQDI+EC G+ C N G
Sbjct: 2628 ----------------SYKCMCPAGFQYEQFSGGCQDINEC--GSAQAPCSYGCSNTEGG 2669
Query: 197 FACQCPPGYQKRGE-QCV 213
+ C CPPGY + G+ CV
Sbjct: 2670 YLCGCPPGYFRIGQGHCV 2687
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
+C G+ D + C DIDEC I PD C G +CVN G + C
Sbjct: 1054 RCDSGFALDSEERNCTDIDECRISPDLCGRG-QCVNTPGDFEC 1095
Score = 37.7 bits (86), Expect = 0.024
Identities = 13/29 (44%), Positives = 19/29 (65%), Gaps = 1/29 (3%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLC 70
C+D+DEC +P C+GG C+N G + C
Sbjct: 244 CQDVDECQAIPGLCQGG-NCINTVGSFEC 271
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 181 bits (458), Expect = 2e-45
Identities = 140/525 (26%), Positives = 216/525 (41%), Gaps = 77/525 (14%)
Query: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII--VNNEQ 83
Y C G + C+DIDEC + C G C N G Y C+ + ++
Sbjct: 5129 YCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGL 5188
Query: 84 PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVI---R 140
Q+ + +S A G PG GR + R
Sbjct: 5189 SCQDINECQESSPCHQRCFNAIGSFHCGCEPG-------------YQLKGRKCMDVNECR 5235
Query: 141 RNPADPQRIPSNPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
+N P + N + C G ++E+ C DIDEC GTH CR +Q+C N RGS
Sbjct: 5236 QNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGS 5295
Query: 197 FACQCPPGYQKR--GEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
+ C CP GY+ + G C+DI+EC +P C +C NTPGSF C C PG L + +C
Sbjct: 5296 YRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCA 5355
Query: 254 DINECD-----------------ASNQCAQQCYNILGSFICQ------------------ 278
+ +N QQ Y
Sbjct: 5356 GLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTI 5415
Query: 279 ---CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRS-RTCQD 334
C +G E S D C DIDEC + CQ++C N G + C+CP GYQ+ + +TCQD
Sbjct: 5416 RKTCPEGSEASHD--TCVDIDECENTD-ACQHECKNTFGSYQCICPPGYQLTHNGKTCQD 5472
Query: 335 INEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP-ENRCV--CPVSNAMCRELP 390
I+EC E C + MC+N G ++C PC Y P C+ CP ++ C P
Sbjct: 5473 IDECLEQNVHCGPNRMCFNMRGSYQCID-TPCPPNYQRDPVSGFCLKNCPPNDLECALSP 5531
Query: 391 QSIVYKYMSIRSDRSVPSDIFQIQATTI--YANTINTFRIKSGNENGEFYLRQTSPVSAM 448
++ YK +S+ + D+ ++ A T + TF + + F LR + + +
Sbjct: 5532 YALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDEN-LKGV 5590
Query: 449 LVLVKSLSGPREHIVDLEMLTVSSIGT--FRTSSVLRLTIIVGPF 491
+ + L + + + + S+ GT ++T+ ++ + + P+
Sbjct: 5591 VYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSAYPY 5635
Score = 153 bits (387), Expect = 3e-37
Identities = 87/230 (37%), Positives = 119/230 (51%), Gaps = 25/230 (10%)
Query: 158 QCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVD 214
QC +G+ S C D DEC AG C N G++ C CP G G C D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNP---CSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147
Query: 215 IDECTIPPY-CH--QRCVNTPGSFYC--QCSPGFQLAANNYTCVDINECDASNQCAQQCY 269
IDEC + + CH Q C NT GS+ C +C GF+ ++ +C DINEC S+ C Q+C+
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCF 5207
Query: 270 NILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSC--MCPQGYQVV 327
N +GSF C C GY+L + C D++ECR + C N G + C +CP G
Sbjct: 5208 NAIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKA 5265
Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCY-PR--------NPCQD 367
+ TC DI+EC + T++CR +++C N G +RC PR PC D
Sbjct: 5266 ENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD 5315
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 179 bits (455), Expect = 4e-45
Identities = 119/389 (30%), Positives = 175/389 (44%), Gaps = 50/389 (12%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVN----------NEQP 84
C D++EC+ P C G +CVN G + C L + ++ V+ +E
Sbjct: 867 CDDVNECESFPGVCPNG-RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDE 925
Query: 85 QQETQPAEG-------TSGATTGVVAAS-----SMATSGVLPGGGFVASAAAVAGPEMQT 132
T P + + GA GV + S+ + + P G AS ++G
Sbjct: 926 CGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK 985
Query: 133 GRNNFVIRRNPADPQRIPSNP-SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVC 190
N + + S CA G+ ++ C DIDEC C C
Sbjct: 986 DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTC 1044
Query: 191 INLRGSFACQCPPGYQKRG---EQCVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQL 245
+N GSF C+C PGY+ + C+D+DEC P + C NT GS+ CQC PG +L
Sbjct: 1045 VNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHEL 1104
Query: 246 AANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSY 303
A C DI+EC S+ QC N++G+F C C+ G++ + DR C DI+ECR +
Sbjct: 1105 TAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNG 1164
Query: 304 LCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGFRCYPR 362
C C+N G + C C QGY ++ R C D++ECE + C N GG RC
Sbjct: 1165 GCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCL-- 1222
Query: 363 NPCQDPYILTPENR-CV----CPVSNAMC 386
C D ++ TP+ R CV C ++ +C
Sbjct: 1223 --CYDGFMATPDMRTCVDVDECDLNPHIC 1249
Score = 167 bits (423), Expect = 2e-41
Identities = 86/227 (37%), Positives = 116/227 (51%), Gaps = 15/227 (6%)
Query: 159 CAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDE 217
C GY E C+D+DECT+ HNC+ +C+N G+F C+CPPG+ + + C D DE
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQACFDNDE 2488
Query: 218 CTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
C+ P H C NTPGSF C+C GF L ++ + C D+NECD ++C C N LG
Sbjct: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGG 2548
Query: 275 FICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRS-RTC 332
+ C C QG+ S C D +EC S C C N G F C+CP G+ ++ C
Sbjct: 2549 YRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608
Query: 333 QDINECE-TTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
Q+++EC C C N GGF C C Y + CV
Sbjct: 2609 QEVDECAGRRGPC--SYSCANTPGGFLC----GCPQGYFRAGQGHCV 2649
Score = 166 bits (420), Expect = 4e-41
Identities = 112/364 (30%), Positives = 164/364 (45%), Gaps = 43/364 (11%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G++ P RQ C DI+EC + C + C+N G Y C ++ + + +
Sbjct: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCD--VHCINTEGSYRCSCGQGYSLMPDGRACADV 1197
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGG-------GFVASAAAVAGPEMQTGRNNFVIRR 141
E V T+ +PGG GF+A+ P+M+T +
Sbjct: 1198 DECEENPR-----VCDQGHCTN--MPGGHRCLCYDGFMAT------PDMRTCVDVDECDL 1244
Query: 142 NP-----ADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRG 195
NP D + + S C GY + C D+DEC G HNC + C+N+ G
Sbjct: 1245 NPHICLHGDCEN--TKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302
Query: 196 SFACQCPPGYQKRGEQCVDIDECTIPPY-CHQR--CVNTPGSFYCQCSPGFQLAANNYTC 252
SF+C+C PG+ G +C D+DEC + C R C+N PGS+ C C GF A + + C
Sbjct: 1303 SFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGDGFFC 1360
Query: 253 VDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCV 310
D +EC + QC N G + C+C G++ + D C+D+DEC + C
Sbjct: 1361 EDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCE 1420
Query: 311 NEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPY 369
N PG F C+C GY++ R C DINEC C + +C N G + C C +
Sbjct: 1421 NLPGMFRCICNGGYELDRGGGNCTDINECADPVNC-INGVCINTPGSYLC----SCPQDF 1475
Query: 370 ILTP 373
L P
Sbjct: 1476 ELNP 1479
Score = 159 bits (401), Expect = 7e-39
Identities = 82/193 (42%), Positives = 106/193 (54%), Gaps = 8/193 (4%)
Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQRCV 229
Q ID C T+ C + C+ S+ C+C GY + RGE C+D+DECT P H CV
Sbjct: 407 QTIDICRHFTNLCLNGR-CLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGDCV 464
Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSS 287
N PG+++C+C PGFQ CVD++EC S +C N GSF C CN G+ELS
Sbjct: 465 NIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSP 524
Query: 288 DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECRE 346
D NC D +EC TS+ C+NE G FSC+C G+ + C DI+EC+T C
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN 584
Query: 347 DEMCWNYHGGFRC 359
C N G FRC
Sbjct: 585 GH-CTNTEGSFRC 596
Score = 158 bits (399), Expect = 1e-38
Identities = 130/439 (29%), Positives = 176/439 (40%), Gaps = 100/439 (22%)
Query: 28 QCTDGYEWD-PVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
+C GYE + + C D+DEC P C+GG C N G Y C + P
Sbjct: 1054 ECFPGYESGFMLMKNCMDVDECARDPLLCRGG-TCTNTDGSYKC-----------QCPPG 1101
Query: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAV-----AGPEMQTGRNNFV--- 138
A+GT+ + S G+ P G V A AG + R V
Sbjct: 1102 HELTAKGTACEDIDECSLS----DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDIN 1157
Query: 139 ---IRRNPADPQRIPSNPSHRIQCAAGY------------EQSEHN-------------- 169
++ D I + S+R C GY ++ E N
Sbjct: 1158 ECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPG 1217
Query: 170 -----------------VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
C D+DEC H C C N +GSF C C GY +K
Sbjct: 1218 GHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGAT 1276
Query: 211 QCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQ 266
C D+DEC + + H C+N PGSF C+C PG+ + + C D++EC ++C+
Sbjct: 1277 GCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSP 1334
Query: 267 Q--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQG 323
+ C N+ GS+ C C QG+ + D CED DEC + LC QC+N PG + C C G
Sbjct: 1335 RGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMG 1392
Query: 324 YQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-------TPEN 375
+ R CQD++EC N C C N G FRC C Y L T N
Sbjct: 1393 FDPTEDHRACQDVDECAQGNLCAFGS-CENLPGMFRCI----CNGGYELDRGGGNCTDIN 1447
Query: 376 RCVCPVS--NAMCRELPQS 392
C PV+ N +C P S
Sbjct: 1448 ECADPVNCINGVCINTPGS 1466
Score = 157 bits (398), Expect = 2e-38
Identities = 114/350 (32%), Positives = 151/350 (43%), Gaps = 38/350 (10%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLC--------LPKTAQIIVNNEQP---QQETQP 90
C D +EC PD C G +CVN G + C P + + P +
Sbjct: 2250 CTDDNECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTM 2308
Query: 91 AEGTSGATTGVVAASSMATSG----------VLPGGGFVASAAAVAGPEMQTGRNNFVIR 140
S ++ V A G LPG GR+ R
Sbjct: 2309 CRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECR 2368
Query: 141 RNP---ADPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
A + I S S R C AGY + C D+DEC+ C +C N +GS
Sbjct: 2369 MLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF--LCKNTKGS 2426
Query: 197 FACQCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
F C CP GY ++ G C D+DECT + C CVNT G+F C+C PGF ++ C
Sbjct: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGF--TQHHQACF 2484
Query: 254 DINECDAS-NQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCV 310
D +EC A C C+N GSF C+C+QG+ L S CED++EC + CQ+ C
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHGCQ 2543
Query: 311 NEPGKFSCMCPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
N+ G + C CPQG+ Q + C D NEC + C N GGFRC
Sbjct: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRC 2593
Score = 151 bits (382), Expect = 1e-36
Identities = 106/368 (28%), Positives = 154/368 (41%), Gaps = 38/368 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C GY + C+DIDEC C G C N G Y C+ + VN +
Sbjct: 1589 ECPPGYHLSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYTCVCPAEYLQVNGGNNCMD 1647
Query: 88 TQPA------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGP----------EMQ 131
+ + GT M G + A P
Sbjct: 1648 MRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQA 1707
Query: 132 TGRNNFVIRRNPADPQRIPSNP-------------SHRIQCAAGYEQSEHNV-CQDIDEC 177
G + P D P S R +C AG+ + + C+D+DEC
Sbjct: 1708 PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767
Query: 178 TAGTHNCRADQVCINLRGSFACQCPPGYQ-KRGEQCVDIDECT-IPPYC-HQRCVNTPGS 234
+ C+ + CIN+ GS+ C+C GY+ G CV +EC IP C H C++T GS
Sbjct: 1768 GSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGS 1827
Query: 235 FYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
+ C C GFQ +A+ C+DI+ECD C NI+GS+ C C G+ ++ + +C D
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNG-DCVD 1886
Query: 295 IDECRT-SSYLCQY-QCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCW 351
DEC T +C++ C+N G F C+C G+++ + C D NEC + C
Sbjct: 1887 FDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQ 1946
Query: 352 NYHGGFRC 359
N G FRC
Sbjct: 1947 NLEGSFRC 1954
Score = 147 bits (372), Expect = 2e-35
Identities = 81/208 (38%), Positives = 104/208 (50%), Gaps = 9/208 (4%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
+P+ S+R +C GY Q C D+DECT+ C C+N+ G++ C+C PG+Q
Sbjct: 425 LPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGD-CVNIPGTYHCRCYPGFQAT 481
Query: 207 KRGEQCVDIDECTIP-PYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
+ CVD+DEC + CH RCVNT GSF C C+ GF+L+ + CVD NEC S C
Sbjct: 482 PTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC 541
Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
C N GSF C C G+ L+ C DIDEC+T C N G F C C G
Sbjct: 542 VNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGG 601
Query: 324 YQV-VRSRTCQDINECETTNECREDEMC 350
V R C D + T E C
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSC 629
Score = 147 bits (372), Expect = 2e-35
Identities = 114/390 (29%), Positives = 154/390 (39%), Gaps = 56/390 (14%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G++ C DIDEC P+ C G C N G + CL ++ +N +T
Sbjct: 1956 CPPGFQVQS--DHCIDIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDT 2012
Query: 89 QPA-------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRR 141
+ + G + PG G+
Sbjct: 2013 RQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGW----------------------- 2049
Query: 142 NPADPQRI-PSNPSHRIQ--CAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
DP + P S Q C G+ + +D++EC C + VC+N GS
Sbjct: 2050 --GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC-TNGVCVNTDGS 2106
Query: 197 FACQCPPGYQK--RGEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCV 253
F C+CP GY G CVD DEC++ C Q C N G F C C+ GF+ TC
Sbjct: 2107 FRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-MTCE 2165
Query: 254 DINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ---YQC 309
DI+EC + CA +C+N GS++C C GY L D C D+DEC C +C
Sbjct: 2166 DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMEC 2225
Query: 310 VNEPGKFSCMCPQGYQVV--RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQD 367
N G F+C+CP G + + C D NEC + + C N G FRC Q
Sbjct: 2226 KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQP 2285
Query: 368 PYILTP-----ENRCVCPVSNAMCRELPQS 392
LT + C V MCR L S
Sbjct: 2286 SPTLTECHDIRQGPCFAEVLQTMCRSLSSS 2315
Score = 147 bits (370), Expect = 3e-35
Identities = 117/386 (30%), Positives = 161/386 (41%), Gaps = 48/386 (12%)
Query: 12 LALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDEC-DIVPDACKGGMKCVNHYGGYLC 70
L + +TE + T C GY C+D+DEC D D GM+C N G + C
Sbjct: 2176 LCAFRCHNTEGSYLCT-CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC 2234
Query: 71 --------LPKTAQ-IIVNNEQPQQETQPAEGTSGATTGVV----------AASSMATSG 111
LP + + +NE Q G T G + +
Sbjct: 2235 VCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHD 2294
Query: 112 VLPGGGFV-----------ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA 160
+ G F +S+ AV E G R P +P ++R C
Sbjct: 2295 IRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP--LPGTSAYRKLCP 2352
Query: 161 AGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGEQCVDIDEC 218
G + +D+DEC H C A CIN GSF C C GY C+D+DEC
Sbjct: 2353 HGSGYTAEG--RDVDECRMLAHLC-AHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
Query: 219 T-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA-SNQCAQQCYNILGSFI 276
+ +P C C NT GSF C C G+ L + TC D++EC + + C C N +G+F
Sbjct: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
Query: 277 CQCNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSCMCPQGYQVVRS-RTCQ 333
C+C G+ + C D DEC C C N PG F C C QG+ +V S C+
Sbjct: 2470 CRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
Query: 334 DINECETTNECREDEMCWNYHGGFRC 359
D+NEC+ + C+ C N GG+RC
Sbjct: 2528 DVNECDGPHRCQHG--CQNQLGGYRC 2551
Score = 142 bits (357), Expect = 9e-34
Identities = 118/403 (29%), Positives = 178/403 (44%), Gaps = 55/403 (13%)
Query: 19 DTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-------L 71
+T E T +G++ + + +DIDEC +P C+GG CVN +G + C L
Sbjct: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGG-DCVNTFGSFQCECPPGYHL 1596
Query: 72 PKTAQIIVNNEQPQQET-----QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
+ +I + ++ + T G T V A + +G G + +V
Sbjct: 1597 SEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNG---GNNCMDMRKSVC 1653
Query: 127 GPEMQ-TGRNNFVIR----------------RNPADPQRIPSNPSHRIQC---AAGYEQS 166
T +N P + P +P ++I C A G+
Sbjct: 1654 FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTD 1713
Query: 167 EH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDEC-TIPP 222
H DIDEC C A+ +CIN GSF C+CP G+ C D+DEC +
Sbjct: 1714 IHTGKPLDIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRES 1772
Query: 223 YCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQ-QCYNILGSFICQ 278
C Q C+N PGS+ C+C+ G++L+ CV NEC + N C+ C + GS++C
Sbjct: 1773 PCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCL 1831
Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINEC 338
C++G++ S+D+ C DIDEC C N G ++C+C G+ V + C D +EC
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQP-CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDEC 1890
Query: 339 ETT--NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV 378
T CR C N G F C CQD + LT + + CV
Sbjct: 1891 TTLVGQVCRFGH-CLNTAGSFHCL----CQDGFELTADGKNCV 1928
Score = 122 bits (306), Expect = 7e-28
Identities = 115/378 (30%), Positives = 151/378 (39%), Gaps = 62/378 (16%)
Query: 43 KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVV 102
+D++EC P C G+ CVN G + C E P + G + T
Sbjct: 2083 EDVNECAENPGVCTNGV-CVNTDGSFRC-----------ECPFGYSLDFTGINCVDTDEC 2130
Query: 103 AASSMATSGVLPG--GGFVASAAAVAGPE-MQTGRNNFVIRRNPADPQRIPSNP--SHRI 157
+ G GGF + A P M T + NP N S+
Sbjct: 2131 SVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLC 2190
Query: 158 QCAAGYEQSEHN-VCQDIDECTAGTHNCRA-DQVCINLRGSFACQCPPGYQK---RGEQC 212
C AGY E +C+D+DEC G +C A C NL G+FAC CPPG + GE C
Sbjct: 2191 TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGC 2250
Query: 213 VDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYN 270
D +EC P + RCVNT GSF C C GFQ + C DI + + Q
Sbjct: 2251 TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCR 2310
Query: 271 ILGSFI-------CQCNQG------YEL------SSDRLNC----------EDIDECRTS 301
L S C C G EL S+ R C D+DECR
Sbjct: 2311 SLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRML 2370
Query: 302 SYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINEC-ETTNECREDEMCWNYHGGFR 358
++LC + +C+N G F C C GY + TC D++EC + C +C N G F
Sbjct: 2371 AHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFL 2428
Query: 359 CYPRNPCQDPYILTPENR 376
C C Y+L + R
Sbjct: 2429 C----SCPRGYLLEEDGR 2442
Score = 121 bits (303), Expect = 2e-27
Identities = 105/387 (27%), Positives = 145/387 (37%), Gaps = 55/387 (14%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ P C DIDEC P C G C N G + C + + + +T
Sbjct: 557 CKPGFLLAPGGHYCMDIDECQ-TPGICVNG-HCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
GA A G S A P+ G Q
Sbjct: 615 HVRSTCYGAIEKGSCARPFP-------GTVTKSECCCANPDHGFGE----------PCQL 657
Query: 149 IPSNPSHRIQ--CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
P+ S Q C++G + +DI+EC C A+ VC NLRGS+ C C GY+
Sbjct: 658 CPAKDSAEFQALCSSGLGITTDG--RDINECALDPEVC-ANGVCENLRGSYRCVCNLGYE 714
Query: 207 K--RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
G+ C D+DEC + C N+PGS+ C C PGF + C D++EC +S
Sbjct: 715 AGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP 774
Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCED---------IDECRTSSYL----CQYQC 309
+ C N+ GS+ C+C G L C D I E R L + +C
Sbjct: 775 CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSEC 834
Query: 310 VNEPG----------KFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
G + C +G+ + TC D+NECE+ + C N G FRC
Sbjct: 835 CATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC 894
Query: 360 YPRNPCQDPYILTPENRCVCPVSNAMC 386
C + +L R V C
Sbjct: 895 ----ECPEGLMLDASGRLCVDVRLEPC 917
Score = 119 bits (297), Expect = 8e-27
Identities = 113/422 (26%), Positives = 165/422 (39%), Gaps = 70/422 (16%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-LPKTAQIIVNNE--QPQ 85
C GYE + C D+DEC + C G C N G Y C P + E +
Sbjct: 709 CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSPGSYSCSCPPGFHFWQDTEICKDV 767
Query: 86 QETQPAEGTSGATTGVVAASSMAT---SGVLPGGGF-VASAAAVAGPEMQTGRNNFVIRR 141
E + SG + + + S + P G F + S ++Q R ++
Sbjct: 768 DECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG 827
Query: 142 NPADPQRIPS------NPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCI 191
+ + +P R + CA G+ + C D++EC + C + C+
Sbjct: 828 ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGR-CV 886
Query: 192 NLRGSFACQCPPGYQ--KRGEQCVDI-----------DEC--TIP-PYCHQRCVNTPGSF 235
N GSF C+CP G G CVD+ DEC T+P Y C + G+
Sbjct: 887 NTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAV 946
Query: 236 Y---CQCSP-------------GFQLAANNYTC-----VDINECDA-SNQCAQ-QCYNIL 272
+ C+ P G A+ ++ D+NEC C C N +
Sbjct: 947 WGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTV 1006
Query: 273 GSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQ--VVRS 329
GSF C C G+ L + NC DIDECR S LC Q CVN PG F C C GY+ +
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM 1066
Query: 330 RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV-----CPVSNA 384
+ C D++EC C N G ++C C + LT + C +S+
Sbjct: 1067 KNCMDVDECARDPLLCRGGTCTNTDGSYKC----QCPPGHELTAKGTACEDIDECSLSDG 1122
Query: 385 MC 386
+C
Sbjct: 1123 LC 1124
Score = 114 bits (286), Expect = 2e-25
Identities = 93/345 (26%), Positives = 143/345 (41%), Gaps = 37/345 (10%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTS----GA 97
C+D+DEC VP C+GG CVN G + C + ++ ++ + S G
Sbjct: 245 CQDVDECQAVPGLCQGG-SCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
Query: 98 TTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRI 157
G +A G A+ PE+ R + ++ A QR+P P H
Sbjct: 304 CAGDLAGHYTRRQCCCDRGRCWAAGPV---PELCPPRGSNEFQQLCA--QRLPLLPGHPG 358
Query: 158 QCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP---PGYQKRG----E 210
+ + + H GS A P PG G
Sbjct: 359 LFPGLLGFGSNGMGPPLGPARLNPH------------GSDARGIPSLGPGNSNIGTATLN 406
Query: 211 QCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYN 270
Q +DI + RC+ TP S+ C+C+ G+ C+D++EC +S C N
Sbjct: 407 QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG-ECIDVDECTSSPCHHGDCVN 465
Query: 271 ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQV-VR 328
I G++ C+C G++ + R C D+DEC S LC +CVN G F C+C G+++
Sbjct: 466 IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525
Query: 329 SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP 373
+ C D NEC T+ C + +C N G F C C+ ++L P
Sbjct: 526 GKNCVDHNECATSTMC-VNGVCLNEDGSFSCL----CKPGFLLAP 565
Score = 112 bits (280), Expect = 8e-25
Identities = 123/465 (26%), Positives = 176/465 (37%), Gaps = 124/465 (26%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-LPKTAQI------IVNN 81
C GYE D C DI+EC P C G+ C+N G YLC P+ ++ V+
Sbjct: 1430 CNGGYELDRGGGNCTDINEC-ADPVNCINGV-CINTPGSYLCSCPQDFELNPSGVGCVDT 1487
Query: 82 EQPQQETQPAE-GTSGAT------TGVVAASSMATSG--------VLPGGGFVASAAAVA 126
+ + G SG + GV AS + G + P
Sbjct: 1488 RAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCP 1547
Query: 127 GPEMQTGRNNFVIRRNPADPQRIP----------SNPSHRIQCAAGYEQSEHN-VCQDID 175
G E VI + + Q +P + S + +C GY SEH +C+DID
Sbjct: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607
Query: 176 EC--------------TAGTHNC---------RADQVCINLRGSFA-------CQ----- 200
EC T G + C C+++R S CQ
Sbjct: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAF 1667
Query: 201 -----------------------CP----PGYQKR-GEQC------------VDIDEC-T 219
CP P YQ G Q +DIDEC
Sbjct: 1668 NVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGE 1727
Query: 220 IPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSF 275
IP C C+N GSF C+C GF + C D++EC + QQ C NI GS+
Sbjct: 1728 IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSY 1787
Query: 276 ICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQVVRSRT-CQ 333
C+C +GY+LS C +ECR +C + C++ G + C+C +G+Q +T C
Sbjct: 1788 RCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846
Query: 334 DINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
DI+EC+ + + C N G + C C +++T CV
Sbjct: 1847 DIDECD--RQPCGNGTCKNIIGSYNCL----CFPGFVVTHNGDCV 1885
Score = 111 bits (278), Expect = 1e-24
Identities = 113/410 (27%), Positives = 151/410 (36%), Gaps = 78/410 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G++ + C DIDECD P C G C N G Y CL ++ +N
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQP--CGNGT-CKNIIGSYNCLCFPGFVVTHNGDCVDFD 1888
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN------ 142
+ T +V + G F G E+ N V
Sbjct: 1889 E--------CTTLVGQVCRFGHCLNTAGSF--HCLCQDGFELTADGKNCVDTNECLSLAG 1938
Query: 143 ---PADPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFA 198
P Q + S R C G++ QS+H C DIDEC+ + C C N GSF
Sbjct: 1939 TCLPGTCQNLEG--SFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFG-TCTNSPGSFQ 1993
Query: 199 CQCPPGY--QKRGEQCVDIDE-----------CTIPPYCHQR-----CVNTPGSFY---C 237
C CPPG+ G +C D + C++P + C PG + C
Sbjct: 1994 CLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC 2053
Query: 238 QCSPGFQLAANNYTCV--------------DINEC-DASNQCAQQ-CYNILGSFICQCNQ 281
+ P AA C D+NEC + C C N GSF C+C
Sbjct: 2054 ELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPF 2113
Query: 282 GYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETT 341
GY L +NC D DEC Q C N G F C C G++ TC+DI+EC +
Sbjct: 2114 GYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDEC-SL 2172
Query: 342 NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQ 391
N C N G + C C Y L + AMCR++ +
Sbjct: 2173 NPLLCAFRCHNTEGSYLC----TCPAGYTLRED--------GAMCRDVDE 2210
Score = 110 bits (275), Expect = 3e-24
Identities = 98/373 (26%), Positives = 138/373 (36%), Gaps = 93/373 (24%)
Query: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
+ +C G++ P RQ C D+DEC + C G +CVN G + C+
Sbjct: 471 HCRCYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQCVCNAG---------- 519
Query: 86 QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
E P +G + A S+M +GV
Sbjct: 520 FELSP-DGKNCVDHNECATSTMCVNGVC-------------------------------- 546
Query: 146 PQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
+ + S C G+ + + C DIDEC T + C N GSF CQC G
Sbjct: 547 ---LNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ--TPGICVNGHCTNTEGSFRCQCLGG 601
Query: 205 YQ--KRGEQCVDIDE---------------------------CTIPPY-----CHQRCVN 230
G CVD C P + C
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAK 661
Query: 231 TPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQ-QCYNILGSFICQCNQGYELSSD 288
F CS G + + DINEC + CA C N+ GS+ C CN GYE +
Sbjct: 662 DSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYEAGAS 718
Query: 289 RLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECRE 346
+C D+DEC +S LC C N PG +SC CP G+ + + C+D++EC ++ C
Sbjct: 719 GKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPC-V 776
Query: 347 DEMCWNYHGGFRC 359
+C N G + C
Sbjct: 777 SGVCRNLAGSYTC 789
Score = 104 bits (260), Expect = 2e-22
Identities = 114/436 (26%), Positives = 155/436 (35%), Gaps = 108/436 (24%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C GY D VR +C D+DEC P C G CVN G Y C P +
Sbjct: 434 ECNVGYTQD-VRGECIDVDECTSSP--CHHG-DCVNIPGTYHC----------RCYPGFQ 479
Query: 88 TQPAEGTSGATTGVVAASSMATSG--VLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
P + + + G V G F AG E+ N V
Sbjct: 480 ATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF--QCVCNAGFELSPDGKNCV------- 530
Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
+HN C C G VC+N GSF+C C PG+
Sbjct: 531 ---------------------DHNECATSTMCVNG--------VCLNEDGSFSCLCKPGF 561
Query: 206 --QKRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDI------- 255
G C+DIDEC P C + C NT GSF CQC G + + CVD
Sbjct: 562 LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621
Query: 256 ------------------NECDASN------QCAQQC-YNILGSFICQCNQGYELSSDRL 290
+EC +N + Q C F C+ G +++D
Sbjct: 622 GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG- 680
Query: 291 NCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRS-RTCQDINECETTNECREDE 348
DI+EC +C C N G + C+C GY+ S + C D++EC + ++
Sbjct: 681 --RDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG 738
Query: 349 MCWNYHGGFRCYPRNPC-------QDPYILTPENRCV-CPVSNAMCRELPQSIVYKYMSI 400
C N G + C C QD I + C+ P + +CR L S Y
Sbjct: 739 WCQNSPGSYSC----SCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS--YTCKCG 792
Query: 401 RSDRSVPSDIFQIQAT 416
R PS F + +T
Sbjct: 793 PGSRLDPSGTFCLDST 808
Score = 99.0 bits (245), Expect = 9e-21
Identities = 75/265 (28%), Positives = 107/265 (40%), Gaps = 24/265 (9%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY D C D+DEC VP C C N G +LC ++ +++
Sbjct: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLL------EEDG 2441
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP----A 144
+ + T+ + + V G F Q +N P A
Sbjct: 2442 RTCKDLDECTSRQHNCQFLCVNTV---GAFTCRCPPGFTQHHQACFDNDECSAQPGPCGA 2498
Query: 145 DPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
+ S R +C G+ S + C+D++EC G H C+ C N G + C CP
Sbjct: 2499 HGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQ--HGCQNQLGGYRCSCPQ 2555
Query: 204 GYQKRGE--QCVDIDECTI-PPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC- 258
G+ + + QCVD +EC + PP C C NT G F C C GF C +++EC
Sbjct: 2556 GFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECA 2615
Query: 259 DASNQCAQQCYNILGSFICQCNQGY 283
C+ C N G F+C C QGY
Sbjct: 2616 GRRGPCSYSCANTPGGFLCGCPQGY 2640
Score = 92.0 bits (227), Expect = 1e-18
Identities = 108/451 (23%), Positives = 152/451 (33%), Gaps = 112/451 (24%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC--LPKTA----QIIVNNE 82
C GY C D+DEC++ C C+N G + C LP + +E
Sbjct: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDE 1324
Query: 83 QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN 142
QE + + G V + G GF + N
Sbjct: 1325 CVSQEHRCSP--RGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNG------ 1376
Query: 143 PADPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGT-------------------- 181
Q + + +R +C G++ +E H CQD+DEC G
Sbjct: 1377 ----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNG 1432
Query: 182 --------HNCR-----------ADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTI 220
NC + VCIN GS+ C CP ++ G CVD
Sbjct: 1433 GYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNC 1492
Query: 221 PPYCHQR-------------------CVNTPGSFY---CQCSP---------------GF 243
H R C + G + C+ P GF
Sbjct: 1493 FLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF 1552
Query: 244 QLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
Q DI+EC Q C N GSF C+C GY LS CEDIDEC T
Sbjct: 1553 QPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTH 1612
Query: 302 SYLC-QYQCVNEPGKFSCMCPQGY-QVVRSRTCQDINEC---ETTNECREDEMCWNYHGG 356
S +C C N G ++C+CP Y QV C D+ + N ++E+ +N
Sbjct: 1613 SGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRK 1672
Query: 357 FRCYPRN-------PCQD-PYILTPENRCVC 379
C N PC+ P ++P+ + +C
Sbjct: 1673 MCCCSYNIGQAWNRPCEACPTPISPDYQILC 1703
Score = 68.9 bits (167), Expect = 1e-11
Identities = 65/238 (27%), Positives = 87/238 (36%), Gaps = 32/238 (13%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-----LPKTAQIIVNNEQ 83
C GY + + CKD+DEC C+ CVN G + C + Q +N++
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTCRCPPGFTQHHQACFDNDE 2488
Query: 84 PQQETQP--AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGP-EMQTGRNNFVIR 140
+ P A G T G ++ G GP Q G N +
Sbjct: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQL-- 2546
Query: 141 RNPADPQRIPSNPSHRIQCAAGYEQ-SEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
+R C G+ Q S+ C D +EC C C N G F C
Sbjct: 2547 ------------GGYRCSCPQGFTQHSQWAQCVDENECALSPPTC-GSASCRNTLGGFRC 2593
Query: 200 QCPPGY---QKRGEQCVDIDECT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
CP G+ Q G C ++DEC C C NTPG F C C G+ A + CV
Sbjct: 2594 VCPSGFDFDQALG-GCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGH-CV 2649
Score = 60.5 bits (145), Expect = 3e-09
Identities = 71/282 (25%), Positives = 98/282 (34%), Gaps = 55/282 (19%)
Query: 153 PSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ 211
P+ C G+ + H CQD+DEC A C+ C+N+ GSF C+CP G++
Sbjct: 226 PAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSS 284
Query: 212 CVDID---ECTIPPYCHQRCVNTPGSFY----CQCSPGFQLAANNY--TCVDINECDASN 262
D RC Y C C G AA C +
Sbjct: 285 AACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344
Query: 263 QCAQQCYNILGS--------FICQCNQGYELSSDRLN----------------------- 291
CAQ+ + G G L RLN
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
Query: 292 -CEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEM 349
+ ID CR + LC +C+ P + C C GY C D++EC T++ C +
Sbjct: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC-TSSPCHHGD- 462
Query: 350 CWNYHGGFRCYPRNPCQDPYILTPENR-CV----CPVSNAMC 386
C N G + C C + TP + CV C VS +C
Sbjct: 463 CVNIPGTYHC----RCYPGFQATPTRQACVDVDECIVSGGLC 500
Score = 46.6 bits (109), Expect = 5e-05
Identities = 46/188 (24%), Positives = 64/188 (34%), Gaps = 52/188 (27%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C G+ C+D++ECD P C+ G C N GGY C PQ
Sbjct: 2512 ECHQGFTLVSSGHGCEDVNECD-GPHRCQHG--CQNQLGGYRC-----------SCPQGF 2557
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
TQ ++ A S P G + + G
Sbjct: 2558 TQHSQWAQCVDENECALSP-------PTCGSASCRNTLGG-------------------- 2590
Query: 148 RIPSNPSHRIQCAAGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
R C +G++ + CQ++DEC C C N G F C CP GY
Sbjct: 2591 -------FRCVCPSGFDFDQALGGCQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGYF 2641
Query: 207 KRGE-QCV 213
+ G+ CV
Sbjct: 2642 RAGQGHCV 2649
Score = 31.6 bits (70), Expect = 1.7
Identities = 51/218 (23%), Positives = 77/218 (35%), Gaps = 40/218 (18%)
Query: 153 PSHRIQCAAGYEQSEHNVCQDIDECTAGT----HNCRADQVCIN---LRGSFACQCPPGY 205
P R C G+ S+ N+C D A + C+N RG+ +C C GY
Sbjct: 84 PICRRACGEGF-CSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGA-SCLCQKGY 141
Query: 206 QKRGEQCVDIDECTIPPYCHQRCVNTP---GSFYCQCSPGFQLAANNYTCVDINECDASN 262
G C P C + C N G C C GF +C+
Sbjct: 142 T--GTVCGQ-------PICDRGCHNGGRCIGPNRCACVYGFMGP----------QCERDY 182
Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQ 322
+ C+ +G CQ + + L C + R C+ C +P C +
Sbjct: 183 RTGP-CFGQVGPEGCQHQLTGLVCTKALCCATVG--RAWGLPCEL-CPAQPHP----CRR 234
Query: 323 GY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
G+ + + CQD++EC+ + C N G F C
Sbjct: 235 GFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHC 272
Score = 30.0 bits (66), Expect = 5.0
Identities = 15/43 (34%), Positives = 19/43 (44%), Gaps = 2/43 (4%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
+C GY D C D DEC + +G C N GG+ C
Sbjct: 2110 ECPFGYSLDFTGINCVDTDECSVGHPCGQG--TCTNVIGGFEC 2150
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 167 bits (423), Expect = 2e-41
Identities = 109/379 (28%), Positives = 149/379 (39%), Gaps = 97/379 (25%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C+ GY+ P + C D +EC + D CKG +C+N G Y C +
Sbjct: 872 CSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRCINRVGSYSCFCYPGYTL---------- 919
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
TSGAT + GV GG Q
Sbjct: 920 ----ATSGATQECQDINECEQPGVCSGG------------------------------QC 945
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECT-AGTHNCRADQVCINLRGSFAC-QCPPGYQ 206
+ S+ +C GY CQDI+EC GT C D C+N GS+ C C GY+
Sbjct: 946 TNTEGSYHCECDQGYIMVRKGHCQDINECRHPGT--C-PDGRCVNSPGSYTCLACEEGYR 1002
Query: 207 KRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC- 264
+ CVD++EC P C H +C N GSF C C G+++ ++ C D++EC + C
Sbjct: 1003 GQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP 1062
Query: 265 AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDEC-------------RTSSYLCQ---- 306
C N GSF C C GY ++ D CED+DEC S+ C+
Sbjct: 1063 TGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDG 1122
Query: 307 --------------------------YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET 340
+C N G + C+CPQG+Q+ C+D+NEC
Sbjct: 1123 GYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMG 1182
Query: 341 TNECREDEMCWNYHGGFRC 359
C C N HG F C
Sbjct: 1183 EEHCAPHGECLNSHGSFFC 1201
Score = 164 bits (415), Expect = 2e-40
Identities = 109/379 (28%), Positives = 168/379 (44%), Gaps = 32/379 (8%)
Query: 25 TYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQP 84
T C +GY C D++EC + P C G KC N G + C + + ++E+
Sbjct: 993 TCLACEEGYRGQS--GSCVDVNEC-LTPGVCAHG-KCTNLEGSFRCSCEQGYEVTSDEKG 1048
Query: 85 QQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPA 144
Q+ + TG+ + + + G+ + A ++ V
Sbjct: 1049 CQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVC----- 1103
Query: 145 DPQRIPSNPSHRIQCA---AGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
P + +N + C GY S + C+D+DEC +C + C N GS+ C
Sbjct: 1104 -PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTVGSYQCL 1161
Query: 201 CPPGYQ-KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
CP G+Q G C D++EC +C H C+N+ GSF+C C+PGF A +C D++E
Sbjct: 1162 CPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221
Query: 258 CDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRT-SSYLC-QYQCVNEPG 314
C ++ C C N GSF C C G++ S + C DIDEC +C ++C N PG
Sbjct: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG 1281
Query: 315 KFSCM--CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT 372
+ C+ C G+ + + C DI+EC C C N G FRC C + ++
Sbjct: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCL----CDQGFEIS 1337
Query: 373 PEN-RCV----CPVSNAMC 386
P CV C + A+C
Sbjct: 1338 PSGWDCVDVNECELMLAVC 1356
Score = 149 bits (375), Expect = 7e-36
Identities = 82/210 (39%), Positives = 114/210 (54%), Gaps = 14/210 (6%)
Query: 174 IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ-RCVN 230
ID C AG N C+NL + C C PGYQ Q C D +EC P + RC+N
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
Query: 231 TPGSFYCQCSPGFQLAANNYT--CVDINECDASNQCA-QQCYNILGSFICQCNQGYELSS 287
GS+ C C PG+ LA + T C DINEC+ C+ QC N GS+ C+C+QGY +
Sbjct: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY-IMV 963
Query: 288 DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECRE 346
+ +C+DI+ECR +CVN PG ++C+ C +GY+ +S +C D+NEC T C
Sbjct: 964 RKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLTPGVCAH 1022
Query: 347 DEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
+ C N G FRC C+ Y +T + +
Sbjct: 1023 GK-CTNLEGSFRC----SCEQGYEVTSDEK 1047
Score = 143 bits (360), Expect = 4e-34
Identities = 92/258 (35%), Positives = 122/258 (47%), Gaps = 30/258 (11%)
Query: 154 SHRIQCAAGYEQSEHNV---CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY-QKRG 209
S+ C GY + CQDI+EC C Q C N GS+ C+C GY R
Sbjct: 908 SYSCFCYPGYTLATSGATQECQDINECEQ-PGVCSGGQ-CTNTEGSYHCECDQGYIMVRK 965
Query: 210 EQCVDIDECTIPPYCHQ-RCVNTPGSFYC-QCSPGFQLAANNYTCVDINECDASNQCAQ- 266
C DI+EC P C RCVN+PGS+ C C G++ + +CVD+NEC CA
Sbjct: 966 GHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTPGVCAHG 1023
Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSC-MCPQGYQ 325
+C N+ GSF C C QGYE++SD C+D+DEC + + C+N G F+C C GY
Sbjct: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083
Query: 326 VVRSRT-CQDINECETTNECREDEMCWNYHGGFRC------YPRNP----------CQDP 368
V T C+D++EC C +C N G F C Y +P C+DP
Sbjct: 1084 VNEDGTACEDLDECAFPGVC-PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDP 1142
Query: 369 YILTPENRCVCPVSNAMC 386
C V + C
Sbjct: 1143 QSSCLGGECKNTVGSYQC 1160
Score = 139 bits (351), Expect = 4e-33
Identities = 101/313 (32%), Positives = 133/313 (42%), Gaps = 61/313 (19%)
Query: 19 DTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII 78
+T + + C GY P+ C+D+DEC+ +C GG +C N G Y CL
Sbjct: 1110 NTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG-ECKNTVGSYQCLCP----- 1163
Query: 79 VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
Q Q A GT M P G
Sbjct: 1164 -------QGFQLANGTVCEDVN----ECMGEEHCAPHG---------------------- 1190
Query: 139 IRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSF 197
+ + S+ S CA G+ +E CQD+DEC A T C C+N GSF
Sbjct: 1191 --------ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC-ATTDPCVGGH-CVNTEGSF 1240
Query: 198 ACQCPPGYQKRGE--QCVDIDECTI--PPYCHQ-RCVNTPGSFYCQ--CSPGFQLAANNY 250
C C G+Q E +CVDIDEC P C +C N+PGS+ C C PGF +A N
Sbjct: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG- 1299
Query: 251 TCVDINECDASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QY 307
C+DI+EC C C N GSF C C+QG+E+S +C D++EC +C
Sbjct: 1300 DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAA 1359
Query: 308 QCVNEPGKFSCMC 320
C N G F C+C
Sbjct: 1360 LCENVEGSFLCLC 1372
Score = 77.0 bits (188), Expect = 4e-14
Identities = 41/129 (31%), Positives = 59/129 (45%), Gaps = 9/129 (6%)
Query: 253 VDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVN 311
+D A+N C C N+ + C C+ GY+L + C D +EC + +C+N
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
Query: 312 EPGKFSCMCPQGYQVVRS---RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDP 368
G +SC C GY + S + CQDINECE C + C N G + C C
Sbjct: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQ-CTNTEGSYHC----ECDQG 959
Query: 369 YILTPENRC 377
YI+ + C
Sbjct: 960 YIMVRKGHC 968
Score = 67.8 bits (164), Expect = 2e-11
Identities = 61/245 (24%), Positives = 91/245 (37%), Gaps = 25/245 (10%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------P 72
C G+E P C D++EC+++ C G C N G +LCL P
Sbjct: 1330 CDQGFEISPSGWDCVDVNECELMLAVC-GAALCENVEGSFLCLCASDLEEYDAQEGHCRP 1388
Query: 73 KTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQT 132
+ A +E P + PA +G S VL A G
Sbjct: 1389 RGAGGQSMSEAPTGDHAPAPTRMDCYSG--QKGHAPCSSVLGRNTTQAECCCTQGASWGD 1446
Query: 133 GRNNFVIRRNPADPQRIPSNPSH-RIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCI 191
+ + + PS + ++ A + Q+ + D DEC + C+
Sbjct: 1447 ACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT---DADECVIFGPGLCPNGRCL 1503
Query: 192 NLRGSFACQCPPG--YQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANN 249
N + C C PG Y ++C D DEC + CVNT GSF+C CSP L +
Sbjct: 1504 NTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563
Query: 250 YTCVD 254
C++
Sbjct: 1564 QRCMN 1568
Score = 61.2 bits (147), Expect = 2e-09
Identities = 72/319 (22%), Positives = 103/319 (32%), Gaps = 36/319 (11%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---------LPKTAQIIV 79
C G++ P +C DIDEC+ D G KC N G Y C + I
Sbjct: 1244 CETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCID 1303
Query: 80 NNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA------AAVAGPEMQTG 133
+E + G T G + P G AV G +
Sbjct: 1304 IDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCEN 1363
Query: 134 RNNFVIRRNPADPQRIPSNPSH-RIQCAAGYEQSE-----HNVCQDIDECTAGTHNCRAD 187
+ +D + + H R + A G SE H +C +G +
Sbjct: 1364 VEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ---KGH 1420
Query: 188 QVCINLRG----SFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGF 243
C ++ G C C G G+ C D C + G Y +
Sbjct: 1421 APCSSVLGRNTTQAECCCTQG-ASWGDAC---DLCPSEDSAEFSEICPSGKGYIPVEGAW 1476
Query: 244 QLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
YT D C +C N + ++C CN G+ + CED DEC+
Sbjct: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--D 1534
Query: 303 YLCQY-QCVNEPGKFSCMC 320
C+ +CVN G F C C
Sbjct: 1535 LACENGECVNTEGSFHCFC 1553
Score = 59.3 bits (142), Expect = 8e-09
Identities = 33/90 (36%), Positives = 43/90 (47%), Gaps = 6/90 (6%)
Query: 209 GEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCA-- 265
G + + +EC I C RCV + C C GFQL A + CVD+NECD N A
Sbjct: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL 1787
Query: 266 ---QQCYNILGSFICQCNQGYELSSDRLNC 292
C N GS+ C C+ GY + +C
Sbjct: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
Score = 53.5 bits (127), Expect = 4e-07
Identities = 36/127 (28%), Positives = 51/127 (40%), Gaps = 7/127 (5%)
Query: 200 QCPPGYQKRG-EQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
+CP GY++ C DI+EC C CVNT GS+ C C PG L + CV
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK- 665
Query: 258 CDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFS 317
A + CY LG C ++ C + + S C+ + F
Sbjct: 666 --AISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFR 721
Query: 318 CMCPQGY 324
+CP G+
Sbjct: 722 EICPAGH 728
Score = 52.0 bits (123), Expect = 1e-06
Identities = 34/122 (27%), Positives = 50/122 (40%), Gaps = 16/122 (13%)
Query: 139 IRRNPADPQRI-PSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSF 197
I +P P + P + + AG+E + C ++ C G C+ +R +
Sbjct: 1704 ILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGR--------CVRVREGY 1755
Query: 198 ACQCPPGYQKRGEQ--CVDIDEC-----TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNY 250
C C G+Q CVD++EC H C NT GS+ C CSPG+ A
Sbjct: 1756 TCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPP 1815
Query: 251 TC 252
C
Sbjct: 1816 HC 1817
Score = 47.4 bits (111), Expect = 3e-05
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 257 ECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSSYLCQY-QCVN 311
EC N C +C + + C C +G++L + + C D++EC + LC + C N
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
Query: 312 EPGKFSCMCPQGY 324
G + C C GY
Sbjct: 1796 TEGSYRCHCSPGY 1808
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 6/71 (8%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP-ENRCV 378
CPQGY+ + CQDINEC T C++ E C N G + C C+ +L P +RCV
Sbjct: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRSRCV 662
Query: 379 CPVSNAMCREL 389
+ +M + L
Sbjct: 663 SDKAISMLQGL 673
Score = 46.2 bits (108), Expect = 7e-05
Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 7/65 (10%)
Query: 143 PADPQRIPSNP---SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
P P+ P++P + +++C GY++ CQDI+EC T D C+N RGS+ C
Sbjct: 591 PCPPR--PASPVIENGQLECPQGYKRLNLTHCQDINECL--TLGLCKDAECVNTRGSYLC 646
Query: 200 QCPPG 204
C PG
Sbjct: 647 TCRPG 651
Score = 40.8 bits (94), Expect = 0.003
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 7/57 (12%)
Query: 278 QCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
+C QGY+ RLN C+DI+EC T +CVN G + C C G + SR+
Sbjct: 607 ECPQGYK----RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659
Score = 34.3 bits (77), Expect = 0.27
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 10/80 (12%)
Query: 296 DECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINECETTNE----CREDEMC 350
+EC + +CV ++C C +G+Q+ + C D+NEC+ N C C
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG-YC 1793
Query: 351 WNYHGGFRCYPRNPCQDPYI 370
N G +RC+ C Y+
Sbjct: 1794 ENTEGSYRCH----CSPGYV 1809
Score = 30.0 bits (66), Expect = 5.0
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 3/43 (6%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
+C GY+ + C+DI+EC + CK +CVN G YLC
Sbjct: 607 ECPQGYKRLNLTH-CQDINEC-LTLGLCKDA-ECVNTRGSYLC 646
Score = 30.0 bits (66), Expect = 5.0
Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 4/45 (8%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLC 70
C +G++ D C D++ECD + C G C N G Y C
Sbjct: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYRC 1802
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 167 bits (422), Expect = 3e-41
Identities = 122/345 (35%), Positives = 163/345 (47%), Gaps = 31/345 (8%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY R +C+DIDEC + P C +CVN G Y C+P T N Q
Sbjct: 985 CDSGYRMTQ-RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVD 1041
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASA--AAVAGPEMQTGRNNFVIRRNP--A 144
+ E V A+ ++ G ++ S P+ + R+ ++
Sbjct: 1042 ECLEPN-------VCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 1091
Query: 145 DPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
+ Q + S R C GY+ S + C+DIDEC H C Q C N GSF C C
Sbjct: 1092 NGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQ 1149
Query: 204 GYQKRG--EQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECD 259
GY+ G + C DI+EC QR C+NT GS+ C C GFQL +N TC DINEC+
Sbjct: 1150 GYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE 1208
Query: 260 ASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQ--CVNEPGK 315
C Q C N GSF C C QG+ +S+D CEDIDEC ++ +C C N G
Sbjct: 1209 HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 1267
Query: 316 FSCMCPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
F C+C QG+Q + + C D+NECE + + C N G F C
Sbjct: 1268 FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 1312
Score = 163 bits (412), Expect = 4e-40
Identities = 123/421 (29%), Positives = 181/421 (42%), Gaps = 56/421 (13%)
Query: 41 QCKDIDECDIVPDACKGGMKCVNH--------YGGYLCLPKTAQIIVNNEQPQQETQPAE 92
Q +I+EC + PD C G C+N Y GY + + + +E Q + ++
Sbjct: 871 QVTEINECTVNPDICGAG-HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 929
Query: 93 GTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSN 152
G T G A GF+AS ++ V + + +
Sbjct: 930 GRCENTEGSFLCICPA--------GFMASEEGTNCIDVDECLRPDVC----GEGHCVNTV 977
Query: 153 PSHRIQ-CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE 210
+ R + C +GY ++ C+DIDEC C D+ C+N GS+ C C G++
Sbjct: 978 GAFRCEYCDSGYRMTQRGRCEDIDECL-NPSTC-PDEQCVNSPGSYQCVPCTEGFRGWNG 1035
Query: 211 QCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QC 268
QC+D+DEC P C + C N GS+ C C G+ ++ C DI+EC N C QC
Sbjct: 1036 QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC 1095
Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV- 327
N GSF C C QGY+LS+ + CEDIDEC+ QC N G F C+C QGY+
Sbjct: 1096 KNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG 1155
Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGF--------------RCYPRNPCQDPYILT 372
C+DINEC E + C+ + C N G + C N C+ P +
Sbjct: 1156 LGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCG 1214
Query: 373 PENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTI------YANTINTF 426
P+ C+ + C + + SI +D DI + T+ NT +F
Sbjct: 1215 PQGECLNTEGSFHC------VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 1268
Query: 427 R 427
R
Sbjct: 1269 R 1269
Score = 144 bits (363), Expect = 2e-34
Identities = 111/384 (28%), Positives = 166/384 (43%), Gaps = 47/384 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGM----------KCVNHY---GGYLCLPKTA 75
C+ G W P ++C + + C GGM + ++H+ G PK
Sbjct: 704 CSVGKAWGPHCEKCP-LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNT 762
Query: 76 QIIVNNEQPQQETQPAEGTSGATTGV-----VAASSMATSGV---LPGGGFVASAAAVAG 127
Q + + P E T VA +AT+ +P +
Sbjct: 763 QPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQ 822
Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQ--------DIDECTA 179
P++ G + I +P P + S + E S + Q +I+ECT
Sbjct: 823 PQLSPGIST--IHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTV 880
Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDECT-IPPYCHQ-RCVNTPGSF 235
C A CINL + C C GY+ ++ +CVDIDECT + C Q RC NT GSF
Sbjct: 881 NPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSF 939
Query: 236 YCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQ-CNQGYELSSDRLNCE 293
C C GF + C+D++EC + C + C N +G+F C+ C+ GY + + R CE
Sbjct: 940 LCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCE 998
Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECREDEMCWN 352
DIDEC S QCVN PG + C+ C +G++ + C D++EC N C + C N
Sbjct: 999 DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ-CLDVDECLEPNVCANGD-CSN 1056
Query: 353 YHGGFRCYPRNPCQDPYILTPENR 376
G + C C Y TP+++
Sbjct: 1057 LEGSYMC----SCHKGYTRTPDHK 1076
Score = 106 bits (264), Expect = 6e-23
Identities = 82/295 (27%), Positives = 118/295 (40%), Gaps = 23/295 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY P + C+DIDEC + C G +C N G + C + + ++
Sbjct: 1065 CHKGYTRTPDHKHCRDIDECQ-QGNLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDI 1122
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
+ G + + V G + + + V +R
Sbjct: 1123 DECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC---- 1178
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
I + S+ C G++ ++ CQDI+EC C C+N GSF C C G+
Sbjct: 1179 INTAGSYDCTCPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSIS 1237
Query: 207 KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQ 263
G C DIDEC C H C NT GSF C C GFQ + CVD+NEC+ S
Sbjct: 1238 ADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGV 1297
Query: 264 CAQQ-CYNILGSFICQC---NQGYELSSDRLNCE-------DIDECRTSSYLCQY 307
C + C N+ GSF+C C NQ Y + + D+D+ + C Y
Sbjct: 1298 CGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1352
Score = 87.8 bits (216), Expect = 2e-17
Identities = 114/460 (24%), Positives = 176/460 (38%), Gaps = 101/460 (21%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQ 76
++TE + T C GY+ + QC+DIDEC C G +C N G + C+ + +
Sbjct: 1096 KNTEGSFRCT-CGQGYQLSAAKDQCEDIDECQ-HRHLCAHG-QCRNTEGSFQCVCDQGYR 1152
Query: 77 IIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+ + + E S G ++ + P G Q N
Sbjct: 1153 ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG-------------FQLDDNK 1199
Query: 137 FVIRRNPAD------PQR--IPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRAD 187
N + PQ + + S C G+ ++ C+DIDEC T C +
Sbjct: 1200 TCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSH 1258
Query: 188 QVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPPYCHQR-CVNTPGSFYCQCSP-- 241
C N GSF C C G+Q + G+ CVD++EC + C + C N GSF C C+
Sbjct: 1259 GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 1318
Query: 242 ------GFQLAANNYTCVDIN---------ECDASNQCAQQCYNILGSFI----CQCNQG 282
Q + T +D++ EC + A C N+L + C C G
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1378
Query: 283 Y---------------------------------ELSSDR--LNCEDIDECRT-SSYLCQ 306
E SS+ N +D DEC +C+
Sbjct: 1379 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1438
Query: 307 YQ-CVNEPGKFSCMCPQG--YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRN 363
C+N + C C QG Y V+ + C D++EC+ + C D C N G + C+
Sbjct: 1439 NGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQDPSSC-IDGQCVNTEGSYNCF--- 1493
Query: 364 PCQDPYIL-TPENRCVCPV-SNAMCRE--LPQSIVYKYMS 399
C P +L E RC+ P SN E + Q + ++++S
Sbjct: 1494 -CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLS 1532
Score = 58.5 bits (140), Expect = 1e-08
Identities = 61/270 (22%), Positives = 97/270 (35%), Gaps = 54/270 (20%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ----P 84
C G +DPV+ QC D+DEC P +C G +CVN G Y C ++ +E+ P
Sbjct: 1453 CKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRP 1510
Query: 85 QQETQPAEGTSG--------------ATTGVVAASSMATSGVLPGGGFVASAAA------ 124
+ + E T + +V + T G A
Sbjct: 1511 AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD 1570
Query: 125 -----------VAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQD 173
V G GR+ V P+ P R +E+ + C
Sbjct: 1571 SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF--LNSFEELQAEECGI 1628
Query: 174 IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECT-----IPPYCHQ 226
++ C G C+ ++ + C C GY + CVD++EC + +
Sbjct: 1629 LNGCENGR--------CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1680
Query: 227 RCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
+C+NT GS+ C C PG+ + C +N
Sbjct: 1681 KCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/82 (39%), Positives = 40/82 (48%), Gaps = 7/82 (8%)
Query: 216 DECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ----CAQ-QCY 269
+EC I C RCV + C C G+ L TCVD+NECD N C +C
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1683
Query: 270 NILGSFICQCNQGYELSSDRLN 291
N GS+ C C GY + SD+ N
Sbjct: 1684 NTDGSYKCLCLPGY-VPSDKPN 1704
Score = 45.8 bits (107), Expect = 9e-05
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 7/94 (7%)
Query: 195 GSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPG----SFYCQCSPGFQLAANNY 250
GS + PG K+ + C + C Q+C P + +C PG++ NN
Sbjct: 565 GSQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVNNT 622
Query: 251 TCVDINECDASNQCAQ-QCYNILGSFICQCNQGY 283
C DINEC C +C N +GS+ C C G+
Sbjct: 623 FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 147 QRIPSNPSHR-----IQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
Q+ P PS+ ++C GY++ + CQDI+EC + C+N GS+ C C
Sbjct: 595 QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTC 652
Query: 202 PPGY 205
G+
Sbjct: 653 KIGF 656
Score = 42.0 bits (97), Expect = 0.001
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 200 QCPPGYQKRGEQ-CVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
+C PGY++ C DI+EC + C + C+NT GS+ C C GF +CV
Sbjct: 611 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666
Score = 39.7 bits (91), Expect = 0.006
Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
C GY+ V + CQDINEC+ C E C N G +RC
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQGVCPNGE-CLNTMGSYRC 650
Score = 35.0 bits (79), Expect = 0.16
Identities = 14/47 (29%), Positives = 25/47 (53%), Gaps = 1/47 (2%)
Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
+C GY+ ++ C+DI+EC+ +C+N G + C C G+
Sbjct: 611 ECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 167 bits (422), Expect = 3e-41
Identities = 122/345 (35%), Positives = 163/345 (47%), Gaps = 31/345 (8%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY R +C+DIDEC + P C +CVN G Y C+P T N Q
Sbjct: 659 CDSGYRMTQ-RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVD 715
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASA--AAVAGPEMQTGRNNFVIRRNP--A 144
+ E V A+ ++ G ++ S P+ + R+ ++
Sbjct: 716 ECLEPN-------VCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 765
Query: 145 DPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
+ Q + S R C GY+ S + C+DIDEC H C Q C N GSF C C
Sbjct: 766 NGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQ 823
Query: 204 GYQKRG--EQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECD 259
GY+ G + C DI+EC QR C+NT GS+ C C GFQL +N TC DINEC+
Sbjct: 824 GYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE 882
Query: 260 ASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQ--CVNEPGK 315
C Q C N GSF C C QG+ +S+D CEDIDEC ++ +C C N G
Sbjct: 883 HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 941
Query: 316 FSCMCPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
F C+C QG+Q + + C D+NECE + + C N G F C
Sbjct: 942 FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 986
Score = 163 bits (412), Expect = 4e-40
Identities = 123/421 (29%), Positives = 181/421 (42%), Gaps = 56/421 (13%)
Query: 41 QCKDIDECDIVPDACKGGMKCVNH--------YGGYLCLPKTAQIIVNNEQPQQETQPAE 92
Q +I+EC + PD C G C+N Y GY + + + +E Q + ++
Sbjct: 545 QVTEINECTVNPDICGAG-HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 603
Query: 93 GTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSN 152
G T G A GF+AS ++ V + + +
Sbjct: 604 GRCENTEGSFLCICPA--------GFMASEEGTNCIDVDECLRPDVC----GEGHCVNTV 651
Query: 153 PSHRIQ-CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE 210
+ R + C +GY ++ C+DIDEC C D+ C+N GS+ C C G++
Sbjct: 652 GAFRCEYCDSGYRMTQRGRCEDIDECL-NPSTC-PDEQCVNSPGSYQCVPCTEGFRGWNG 709
Query: 211 QCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QC 268
QC+D+DEC P C + C N GS+ C C G+ ++ C DI+EC N C QC
Sbjct: 710 QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC 769
Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV- 327
N GSF C C QGY+LS+ + CEDIDEC+ QC N G F C+C QGY+
Sbjct: 770 KNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG 829
Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGF--------------RCYPRNPCQDPYILT 372
C+DINEC E + C+ + C N G + C N C+ P +
Sbjct: 830 LGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCG 888
Query: 373 PENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTI------YANTINTF 426
P+ C+ + C + + SI +D DI + T+ NT +F
Sbjct: 889 PQGECLNTEGSFHC------VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 942
Query: 427 R 427
R
Sbjct: 943 R 943
Score = 144 bits (363), Expect = 2e-34
Identities = 111/384 (28%), Positives = 166/384 (43%), Gaps = 47/384 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGM----------KCVNHY---GGYLCLPKTA 75
C+ G W P ++C + + C GGM + ++H+ G PK
Sbjct: 378 CSVGKAWGPHCEKCP-LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNT 436
Query: 76 QIIVNNEQPQQETQPAEGTSGATTGV-----VAASSMATSGV---LPGGGFVASAAAVAG 127
Q + + P E T VA +AT+ +P +
Sbjct: 437 QPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQ 496
Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQ--------DIDECTA 179
P++ G + I +P P + S + E S + Q +I+ECT
Sbjct: 497 PQLSPGIST--IHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTV 554
Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDECT-IPPYCHQ-RCVNTPGSF 235
C A CINL + C C GY+ ++ +CVDIDECT + C Q RC NT GSF
Sbjct: 555 NPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSF 613
Query: 236 YCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQ-CNQGYELSSDRLNCE 293
C C GF + C+D++EC + C + C N +G+F C+ C+ GY + + R CE
Sbjct: 614 LCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCE 672
Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECREDEMCWN 352
DIDEC S QCVN PG + C+ C +G++ + C D++EC N C + C N
Sbjct: 673 DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ-CLDVDECLEPNVCANGD-CSN 730
Query: 353 YHGGFRCYPRNPCQDPYILTPENR 376
G + C C Y TP+++
Sbjct: 731 LEGSYMC----SCHKGYTRTPDHK 750
Score = 106 bits (264), Expect = 6e-23
Identities = 82/295 (27%), Positives = 118/295 (40%), Gaps = 23/295 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY P + C+DIDEC + C G +C N G + C + + ++
Sbjct: 739 CHKGYTRTPDHKHCRDIDECQ-QGNLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDI 796
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
+ G + + V G + + + V +R
Sbjct: 797 DECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC---- 852
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
I + S+ C G++ ++ CQDI+EC C C+N GSF C C G+
Sbjct: 853 INTAGSYDCTCPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSIS 911
Query: 207 KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQ 263
G C DIDEC C H C NT GSF C C GFQ + CVD+NEC+ S
Sbjct: 912 ADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGV 971
Query: 264 CAQQ-CYNILGSFICQC---NQGYELSSDRLNCE-------DIDECRTSSYLCQY 307
C + C N+ GSF+C C NQ Y + + D+D+ + C Y
Sbjct: 972 CGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1026
Score = 87.8 bits (216), Expect = 2e-17
Identities = 114/460 (24%), Positives = 176/460 (38%), Gaps = 101/460 (21%)
Query: 18 QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQ 76
++TE + T C GY+ + QC+DIDEC C G +C N G + C+ + +
Sbjct: 770 KNTEGSFRCT-CGQGYQLSAAKDQCEDIDECQ-HRHLCAHG-QCRNTEGSFQCVCDQGYR 826
Query: 77 IIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+ + + E S G ++ + P G Q N
Sbjct: 827 ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG-------------FQLDDNK 873
Query: 137 FVIRRNPAD------PQR--IPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRAD 187
N + PQ + + S C G+ ++ C+DIDEC T C +
Sbjct: 874 TCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSH 932
Query: 188 QVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPPYCHQR-CVNTPGSFYCQCSP-- 241
C N GSF C C G+Q + G+ CVD++EC + C + C N GSF C C+
Sbjct: 933 GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 992
Query: 242 ------GFQLAANNYTCVDIN---------ECDASNQCAQQCYNILGSFI----CQCNQG 282
Q + T +D++ EC + A C N+L + C C G
Sbjct: 993 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1052
Query: 283 Y---------------------------------ELSSDR--LNCEDIDECRT-SSYLCQ 306
E SS+ N +D DEC +C+
Sbjct: 1053 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1112
Query: 307 YQ-CVNEPGKFSCMCPQG--YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRN 363
C+N + C C QG Y V+ + C D++EC+ + C D C N G + C+
Sbjct: 1113 NGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQDPSSC-IDGQCVNTEGSYNCF--- 1167
Query: 364 PCQDPYIL-TPENRCVCPV-SNAMCRE--LPQSIVYKYMS 399
C P +L E RC+ P SN E + Q + ++++S
Sbjct: 1168 -CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLS 1206
Score = 58.5 bits (140), Expect = 1e-08
Identities = 61/270 (22%), Positives = 97/270 (35%), Gaps = 54/270 (20%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ----P 84
C G +DPV+ QC D+DEC P +C G +CVN G Y C ++ +E+ P
Sbjct: 1127 CKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRP 1184
Query: 85 QQETQPAEGTSG--------------ATTGVVAASSMATSGVLPGGGFVASAAA------ 124
+ + E T + +V + T G A
Sbjct: 1185 AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD 1244
Query: 125 -----------VAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQD 173
V G GR+ V P+ P R +E+ + C
Sbjct: 1245 SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF--LNSFEELQAEECGI 1302
Query: 174 IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECT-----IPPYCHQ 226
++ C G C+ ++ + C C GY + CVD++EC + +
Sbjct: 1303 LNGCENGR--------CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1354
Query: 227 RCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
+C+NT GS+ C C PG+ + C +N
Sbjct: 1355 KCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/82 (39%), Positives = 40/82 (48%), Gaps = 7/82 (8%)
Query: 216 DECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ----CAQ-QCY 269
+EC I C RCV + C C G+ L TCVD+NECD N C +C
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1357
Query: 270 NILGSFICQCNQGYELSSDRLN 291
N GS+ C C GY + SD+ N
Sbjct: 1358 NTDGSYKCLCLPGY-VPSDKPN 1378
Score = 45.8 bits (107), Expect = 9e-05
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 7/94 (7%)
Query: 195 GSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPG----SFYCQCSPGFQLAANNY 250
GS + PG K+ + C + C Q+C P + +C PG++ NN
Sbjct: 239 GSQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVNNT 296
Query: 251 TCVDINECDASNQCAQ-QCYNILGSFICQCNQGY 283
C DINEC C +C N +GS+ C C G+
Sbjct: 297 FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
Score = 42.4 bits (98), Expect = 0.001
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 147 QRIPSNPSHR-----IQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
Q+ P PS+ ++C GY++ + CQDI+EC + C+N GS+ C C
Sbjct: 269 QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTC 326
Query: 202 PPGY 205
G+
Sbjct: 327 KIGF 330
Score = 42.0 bits (97), Expect = 0.001
Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 200 QCPPGYQKRGEQ-CVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
+C PGY++ C DI+EC + C + C+NT GS+ C C GF +CV
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340
Score = 39.7 bits (91), Expect = 0.006
Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
C GY+ V + CQDINEC+ C E C N G +RC
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQGVCPNGE-CLNTMGSYRC 324
Score = 35.0 bits (79), Expect = 0.16
Identities = 14/47 (29%), Positives = 25/47 (53%), Gaps = 1/47 (2%)
Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
+C GY+ ++ C+DI+EC+ +C+N G + C C G+
Sbjct: 285 ECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 166 bits (420), Expect = 4e-41
Identities = 113/339 (33%), Positives = 154/339 (45%), Gaps = 55/339 (16%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY P + C D++EC+ P G+ C+N G Y C +
Sbjct: 601 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGI-CMNTGGSYNC------------HCNRGY 647
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
+ G G + V + A + GGF NF
Sbjct: 648 RLHVGAGGRSC--VDLNECAKPHLCGDGGFCI---------------NF----------- 679
Query: 149 IPSNPSH-RIQCAAGY--EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPG 204
P H + C GY + S VC+DIDEC + +C D C N GSF C C PG
Sbjct: 680 ----PGHYKCNCYPGYRLKASRPPVCEDIDECRDPS-SC-PDGKCENKPGSFKCIACQPG 733
Query: 205 YQKRGE-QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
Y+ +G C D++EC C C N PGSF C C+ G+ A + +C+D++EC+A +
Sbjct: 734 YRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
Query: 263 QCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
C C N GSF CQC GY LS DR +CEDIDEC + C+N G + C+CP
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
Query: 322 QGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
QG+++V R CQDI+EC + + C C N G + C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
Score = 141 bits (355), Expect = 2e-33
Identities = 86/263 (32%), Positives = 118/263 (44%), Gaps = 55/263 (20%)
Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQ-VCINLRGSFACQCPPGYQ 206
+P P + C GY +H C D++EC A C + +C+N GS+ C C GY+
Sbjct: 591 VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGICMNTGGSYNCHCNRGYR 648
Query: 207 KR----GEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANN-YTCVDINEC- 258
G CVD++EC P C C+N PG + C C PG++L A+ C DI+EC
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
Query: 259 DAS----------------------------------NQCAQ-------QCYNILGSFIC 277
D S N+CA+ C N+ GSF C
Sbjct: 709 DPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRC 768
Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT-CQDIN 336
C QGY + D +C D+DEC C N PG F C C GY + R R+ C+DI+
Sbjct: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828
Query: 337 ECETTNECREDEMCWNYHGGFRC 359
EC+ C + C N +G +RC
Sbjct: 829 ECDFPAACIGGD-CINTNGSYRC 850
Score = 140 bits (352), Expect = 3e-33
Identities = 93/277 (33%), Positives = 127/277 (45%), Gaps = 30/277 (10%)
Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQR--C 228
+ DEC + C + C+ ++C C PGY+ + CVD++EC P R C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 229 VNTPGSFYCQCSPGFQL--AANNYTCVDINECDASNQCAQQ--CYNILGSFICQCNQGYE 284
+NT GS+ C C+ G++L A +CVD+NEC + C C N G + C C GY
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
Query: 285 LSSDRLN-CEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTN 342
L + R CEDIDECR S +C N+PG F C+ C GY+ C+D+NEC +
Sbjct: 693 LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752
Query: 343 ECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPV---------SNAMCRELPQSI 393
C C N G FRC C Y P+ R V N +C P S
Sbjct: 753 PC-SPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
Query: 394 VYKYMS---IRSDRSVPSDIFQ--IQATTIYANTINT 425
+ +S + DRS DI + A I + INT
Sbjct: 808 QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
Score = 109 bits (273), Expect = 5e-24
Identities = 111/421 (26%), Positives = 163/421 (38%), Gaps = 78/421 (18%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVNNEQ---------- 83
C+DI+EC +P C+ G C+N+ G Y C+ P Q I + +
Sbjct: 353 CQDINEC-AMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
Query: 84 PQQETQPAEGTS--------------GA------TTGVVAASSMATSGVLPGGGFVASAA 123
P+ + Q T GA T G A + +G G + ++
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK---GYHILTSH 467
Query: 124 AVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDE------- 176
+ ++ + F+ P PQ++P +PS E+ + E
Sbjct: 468 QTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQS 527
Query: 177 -CTAGTHNCRADQVCINLRGS-----FACQCPPG---YQKRGEQCVDIDECTIPPYC--H 225
TA T R I+ F PP + Q + DEC + H
Sbjct: 528 HPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGH 587
Query: 226 QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSFICQCNQG 282
CV P + C C+PG++ + CVD+NEC+A C C N GS+ C CN+G
Sbjct: 588 GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRG 646
Query: 283 YEL--SSDRLNCEDIDECRTSSYLCQYQ--CVNEPGKFSCMCPQGYQVVRSR--TCQDIN 336
Y L + +C D++EC +LC C+N PG + C C GY++ SR C+DI+
Sbjct: 647 YRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
Query: 337 ECETTNECREDEMCWNYHGGFRCYPRNP---CQDPYILTPENRCV--CPVSNAMCRELPQ 391
EC + C D C N G F+C P Q N C P S C LP
Sbjct: 706 ECRDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG 764
Query: 392 S 392
S
Sbjct: 765 S 765
Score = 107 bits (267), Expect = 2e-23
Identities = 95/357 (26%), Positives = 134/357 (37%), Gaps = 52/357 (14%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
QC GY R C+DIDECD P AC GG C+N G Y CL +V + Q
Sbjct: 810 QCLSGYHLSRDRSHCEDIDECDF-PAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQD- 866
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ S S LP G + + G + F ++ +
Sbjct: 867 --------------IDECSQDPSLCLPHG----ACKNLQGSYVCVCDEGFTPTQDQHGCE 908
Query: 148 RIPSNPSHRIQCAAGYEQSEH-------NVCQDIDECTAGT---HNCRADQVCINLRGSF 197
+ P H+ +C ++ + NV Q C+ G +C + F
Sbjct: 909 EV-EQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967
Query: 198 ACQCPPGYQKRGEQCV---------DIDECTI--PPYCHQ-RCVNTPGSFYCQCSPGFQL 245
CP G + + DIDEC + C + +CVNT + C C GF
Sbjct: 968 HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY 1027
Query: 246 AANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSDRLNC-----EDIDECR 299
N CVD++EC D SN C N G + C C E S + C D+DEC+
Sbjct: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087
Query: 300 TSSYLCQYQCVNEPGKFSCMC-PQGYQVVRSRTCQDINECETTNECREDEMCWNYHG 355
+ +CVN PG + C C P R CQ + E ++CW+ G
Sbjct: 1088 DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ-LPESPAERAPERRDVCWSQRG 1143
Score = 92.8 bits (229), Expect = 6e-19
Identities = 79/292 (27%), Positives = 110/292 (37%), Gaps = 61/292 (20%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
I +N S+R C G+ CQDIDEC+ C C NL+GS+ C C G+
Sbjct: 842 INTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPT 901
Query: 209 GEQ--CVDID------ECTI----PPYC---------HQRC------------------V 229
+Q C +++ EC + +C Q C V
Sbjct: 902 QDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPV 961
Query: 230 NTPGSFYCQCSPGFQLAANNYTC-------VDINEC--DASNQCAQ-QCYNILGSFICQC 279
+ F+ C G +N DI+EC S C + +C N + C C
Sbjct: 962 YSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC 1021
Query: 280 NQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC-PQGYQVVRSRTC-----Q 333
QG+ + L C D+DEC S C N G + C C P R C
Sbjct: 1022 KQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEM 1081
Query: 334 DINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CVCPVSNA 384
D++EC+ CR C N G +RC C+ P++ P R C P S A
Sbjct: 1082 DVDECQDPAACRPGR-CVNLPGSYRC----ECRPPWVPGPSGRDCQLPESPA 1128
Score = 71.6 bits (174), Expect = 2e-12
Identities = 81/282 (28%), Positives = 107/282 (37%), Gaps = 64/282 (22%)
Query: 29 CTDGYEWDPVRQQC-----KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII-VNNE 82
CT E+ P ++QC D+DEC P AC+ G +CVN G Y C + + +
Sbjct: 1062 CTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPG-RCVNLPGSYRCECRPPWVPGPSGR 1119
Query: 83 QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-------QTGRN 135
Q PAE V S G+ G +AGP + + GR
Sbjct: 1120 DCQLPESPAERAPERRD--VCWSQRGEDGMCAG--------PLAGPALTFDDCCCRQGRG 1169
Query: 136 NFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRG 195
+ + P P+ S+ C QSE N D G
Sbjct: 1170 -WGAQCRPCPPRGAGSH------CPTS--QSESNSFWDTSPLLLGK-------------- 1206
Query: 196 SFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI 255
PP + E+ D DEC RCV PG C+C GFQL A+ CVDI
Sbjct: 1207 ------PPRDEDSSEE--DSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDI 1255
Query: 256 NECDASNQ----C-AQQCYNILGSFICQCNQGYELSSDRLNC 292
+EC NQ C +++C N GSF C C G+ S C
Sbjct: 1256 DECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
Score = 64.3 bits (155), Expect = 2e-10
Identities = 82/346 (23%), Positives = 121/346 (34%), Gaps = 103/346 (29%)
Query: 43 KDIDECDIV-PDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGV 101
+DIDEC + + CK G KCVN GY C K N + S GV
Sbjct: 992 RDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050
Query: 102 VAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAA 161
+ GG+ + PA+ +P+ R QC +
Sbjct: 1051 CENTR---------GGYRCACTP------------------PAE-----YSPAQR-QCLS 1077
Query: 162 GYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY---------------- 205
E+ + + CQD C G C+NL GS+ C+C P +
Sbjct: 1078 P-EEMDVDECQDPAACRPGR--------CVNLPGSYRCECRPPWVPGPSGRDCQLPESPA 1128
Query: 206 -----------QKRGEQCVDIDECTIPPYCHQRCVNTPGSFY-CQCSPGFQLAANNYTCV 253
+RGE + P C G + QC P A ++
Sbjct: 1129 ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPT 1188
Query: 254 DINECDA----------------------SNQC---AQQCYNILGSFICQCNQGYELSSD 288
+E ++ S++C + +C G +C+C G++L +
Sbjct: 1189 SQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDAS 1248
Query: 289 RLNCEDIDECR---TSSYLCQYQ-CVNEPGKFSCMCPQGYQVVRSR 330
R C DIDECR LC+ + CVN G F C+C G+ RSR
Sbjct: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF--ARSR 1292
Score = 59.7 bits (143), Expect = 6e-09
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 193 LRGSFACQCPPGYQK-RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNY 250
+RG CP GY++ C DI+EC +P C H C+N PGS+ C C PG L +
Sbjct: 333 VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
Query: 251 TCVDINECDAS---------NQCAQQCYNILGSFICQCNQG 282
C+ + S +QC L +C C+ G
Sbjct: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 53.5 bits (127), Expect = 4e-07
Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 31/142 (21%)
Query: 271 ILGSFICQCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
+ G C QGY+ RLN C+DI+EC C+N PG + C+CP G+ +
Sbjct: 333 VRGEVGADCPQGYK----RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388
Query: 328 RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCR 387
SRT +C ++ E +C+ +++PE++C P++ + R
Sbjct: 389 PSRT-----QC-IADKPEEKSLCFR-----------------LVSPEHQCQHPLTTRLTR 425
Query: 388 ELPQSIVYKYMSIRSDRSVPSD 409
+L V K R R P+D
Sbjct: 426 QLCCCSVGKAWGARCQR-CPTD 446
Score = 42.7 bits (99), Expect = 7e-04
Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 27/168 (16%)
Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRC-------VNTPGSFY----CQCSPGFQLAANNYT 251
PG K+ + C I CH +C V PG C G++ N+
Sbjct: 295 PGLTKQEDCCGSIGTAWGQSKCH-KCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTH 352
Query: 252 CVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC-----EDIDEC---RTSS 302
C DINEC C C N GS+ C C G+ L R C E+ C +
Sbjct: 353 CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPE 412
Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
+ CQ+ + C C G CQ C T E+C
Sbjct: 413 HQCQHPLTTRLTRQLCCCSVG--KAWGARCQ---RCPTDGTAAFKEIC 455
Score = 42.7 bits (99), Expect = 7e-04
Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)
Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
C GY++ CQDI+EC A CR C+N GS+ C CPPG+
Sbjct: 341 CPQGYKRLNSTHCQDINEC-AMPGVCRHGD-CLNNPGSYRCVCPPGH 385
Score = 34.7 bits (78), Expect = 0.20
Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLCLPK 73
+C G++ D R +C DIDEC + CK +CVN G + C+ K
Sbjct: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGSFRCVCK 1285
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 166 bits (420), Expect = 4e-41
Identities = 113/339 (33%), Positives = 154/339 (45%), Gaps = 55/339 (16%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C GY P + C D++EC+ P G+ C+N G Y C +
Sbjct: 601 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGI-CMNTGGSYNC------------HCNRGY 647
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
+ G G + V + A + GGF NF
Sbjct: 648 RLHVGAGGRSC--VDLNECAKPHLCGDGGFCI---------------NF----------- 679
Query: 149 IPSNPSH-RIQCAAGY--EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPG 204
P H + C GY + S VC+DIDEC + +C D C N GSF C C PG
Sbjct: 680 ----PGHYKCNCYPGYRLKASRPPVCEDIDECRDPS-SC-PDGKCENKPGSFKCIACQPG 733
Query: 205 YQKRGE-QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
Y+ +G C D++EC C C N PGSF C C+ G+ A + +C+D++EC+A +
Sbjct: 734 YRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
Query: 263 QCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
C C N GSF CQC GY LS DR +CEDIDEC + C+N G + C+CP
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
Query: 322 QGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
QG+++V R CQDI+EC + + C C N G + C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892
Score = 141 bits (355), Expect = 2e-33
Identities = 86/263 (32%), Positives = 118/263 (44%), Gaps = 55/263 (20%)
Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQ-VCINLRGSFACQCPPGYQ 206
+P P + C GY +H C D++EC A C + +C+N GS+ C C GY+
Sbjct: 591 VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGICMNTGGSYNCHCNRGYR 648
Query: 207 KR----GEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANN-YTCVDINEC- 258
G CVD++EC P C C+N PG + C C PG++L A+ C DI+EC
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708
Query: 259 DAS----------------------------------NQCAQ-------QCYNILGSFIC 277
D S N+CA+ C N+ GSF C
Sbjct: 709 DPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRC 768
Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT-CQDIN 336
C QGY + D +C D+DEC C N PG F C C GY + R R+ C+DI+
Sbjct: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828
Query: 337 ECETTNECREDEMCWNYHGGFRC 359
EC+ C + C N +G +RC
Sbjct: 829 ECDFPAACIGGD-CINTNGSYRC 850
Score = 140 bits (352), Expect = 3e-33
Identities = 93/277 (33%), Positives = 127/277 (45%), Gaps = 30/277 (10%)
Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQR--C 228
+ DEC + C + C+ ++C C PGY+ + CVD++EC P R C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 229 VNTPGSFYCQCSPGFQL--AANNYTCVDINECDASNQCAQQ--CYNILGSFICQCNQGYE 284
+NT GS+ C C+ G++L A +CVD+NEC + C C N G + C C GY
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692
Query: 285 LSSDRLN-CEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTN 342
L + R CEDIDECR S +C N+PG F C+ C GY+ C+D+NEC +
Sbjct: 693 LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752
Query: 343 ECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPV---------SNAMCRELPQSI 393
C C N G FRC C Y P+ R V N +C P S
Sbjct: 753 PC-SPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807
Query: 394 VYKYMS---IRSDRSVPSDIFQ--IQATTIYANTINT 425
+ +S + DRS DI + A I + INT
Sbjct: 808 QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
Score = 109 bits (273), Expect = 5e-24
Identities = 111/421 (26%), Positives = 163/421 (38%), Gaps = 78/421 (18%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVNNEQ---------- 83
C+DI+EC +P C+ G C+N+ G Y C+ P Q I + +
Sbjct: 353 CQDINEC-AMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
Query: 84 PQQETQPAEGTS--------------GA------TTGVVAASSMATSGVLPGGGFVASAA 123
P+ + Q T GA T G A + +G G + ++
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK---GYHILTSH 467
Query: 124 AVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDE------- 176
+ ++ + F+ P PQ++P +PS E+ + E
Sbjct: 468 QTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQS 527
Query: 177 -CTAGTHNCRADQVCINLRGS-----FACQCPPG---YQKRGEQCVDIDECTIPPYC--H 225
TA T R I+ F PP + Q + DEC + H
Sbjct: 528 HPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGH 587
Query: 226 QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSFICQCNQG 282
CV P + C C+PG++ + CVD+NEC+A C C N GS+ C CN+G
Sbjct: 588 GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRG 646
Query: 283 YEL--SSDRLNCEDIDECRTSSYLCQYQ--CVNEPGKFSCMCPQGYQVVRSR--TCQDIN 336
Y L + +C D++EC +LC C+N PG + C C GY++ SR C+DI+
Sbjct: 647 YRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705
Query: 337 ECETTNECREDEMCWNYHGGFRCYPRNP---CQDPYILTPENRCV--CPVSNAMCRELPQ 391
EC + C D C N G F+C P Q N C P S C LP
Sbjct: 706 ECRDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG 764
Query: 392 S 392
S
Sbjct: 765 S 765
Score = 90.5 bits (223), Expect = 3e-18
Identities = 98/394 (24%), Positives = 140/394 (35%), Gaps = 94/394 (23%)
Query: 40 QQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNN----EQPQQETQPAEGTS 95
++C+DIDEC P C C N G Y+C+ + E+ +Q E
Sbjct: 862 RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921
Query: 96 GATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH 155
V S +AT+ + S A G + P + S+
Sbjct: 922 NFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHCEIY------------PCPVYSSAEF 967
Query: 156 RIQC--AAGYEQSEHNVC------QDIDECTA-GTHNCRADQVCINLRGSFACQCPPGYQ 206
C GY Q + V +DIDEC G+ C+ + C+N + + C C G+
Sbjct: 968 HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQGFY 1026
Query: 207 KRGE--QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ 263
G +CVD+DEC C C NT G + C C+P + + C+ E + + +
Sbjct: 1027 YDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPE 1086
Query: 264 CAQQCYNILGS---------------FICQCNQGYELSSDRLNC---------------- 292
C++ G C C QG + C
Sbjct: 1087 RRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSES 1146
Query: 293 ----------------------EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR 330
ED DECR S +CV PG C CP G+Q+ SR
Sbjct: 1147 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVS----GRCVPRPGGAVCECPGGFQLDASR 1202
Query: 331 T-CQDINECETTNE----CREDEMCWNYHGGFRC 359
C DI+EC N+ C+ E C N G FRC
Sbjct: 1203 ARCVDIDECRELNQRGLLCK-SERCVNTSGSFRC 1235
Score = 86.7 bits (213), Expect = 5e-17
Identities = 74/254 (29%), Positives = 110/254 (43%), Gaps = 39/254 (15%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
I +N S+R C G+ CQDIDEC+ C C NL+GS+ C C G+
Sbjct: 842 INTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPT 901
Query: 209 GEQ--CVDIDECTIPPYCHQRC-VNTPGSFYCQCSPGFQLAANNYTCVDINECDAS---- 261
+Q C ++++ P+ + C +N + +C LA N V EC S
Sbjct: 902 QDQHGCEEVEQ----PHHKKECYLNFDDTVFCDS----VLATN----VTQQECCCSLGAG 949
Query: 262 --NQCAQQCYNILGS----FICQCNQGYELSSDRLNC-----EDIDECRT-SSYLC-QYQ 308
+ C + S +C +GY ++ +N DIDEC S +C + +
Sbjct: 950 WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK 1009
Query: 309 CVNEPGKFSCMCPQG-YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQD 367
CVN + C C QG Y C D++EC + CR + +C N GG+RC C
Sbjct: 1010 CVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR-NGVCENTRGGYRC----ACTP 1064
Query: 368 PYILTPENR-CVCP 380
P +P R C+ P
Sbjct: 1065 PAEYSPAQRQCLSP 1078
Score = 83.2 bits (204), Expect = 5e-16
Identities = 77/293 (26%), Positives = 108/293 (36%), Gaps = 45/293 (15%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
QC GY R C+DIDECD P AC GG C+N G Y CL +V + Q
Sbjct: 810 QCLSGYHLSRDRSHCEDIDECDF-PAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQD- 866
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ S S LP G + + G + F ++ +
Sbjct: 867 --------------IDECSQDPSLCLPHG----ACKNLQGSYVCVCDEGFTPTQDQHGCE 908
Query: 148 RIPSNPSHRIQCAAGYEQS-------EHNVCQDIDECTAGT---HNCRADQVCINLRGSF 197
+ P H+ +C ++ + NV Q C+ G +C + F
Sbjct: 909 EV-EQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967
Query: 198 ACQCPPGYQKRGEQCV---------DIDECTI--PPYCHQ-RCVNTPGSFYCQCSPGFQL 245
CP G + + DIDEC + C + +CVNT + C C GF
Sbjct: 968 HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY 1027
Query: 246 AANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
N CVD++EC D SN C N G + C C E S + C +E
Sbjct: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080
Score = 70.1 bits (170), Expect = 4e-12
Identities = 76/276 (27%), Positives = 102/276 (36%), Gaps = 58/276 (21%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ +D +C D+DEC + C+ G+ C N GGY C P E
Sbjct: 1021 CKQGFYYDGNLLECVDVDEC-LDESNCRNGV-CENTRGGYRCACT----------PPAEY 1068
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-------QTGRNNFVIRR 141
PA+ + + A G A +AGP + + GR + +
Sbjct: 1069 SPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRG-WGAQC 1127
Query: 142 NPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
P P+ S+ C QSE N D G
Sbjct: 1128 RPCPPRGAGSH------CPTS--QSESNSFWDTSPLLLGK-------------------- 1159
Query: 202 PPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
PP + E+ D DEC RCV PG C+C GFQL A+ CVDI+EC
Sbjct: 1160 PPRDEDSSEE--DSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL 1214
Query: 262 NQ----C-AQQCYNILGSFICQCNQGYELSSDRLNC 292
NQ C +++C N GSF C C G+ S C
Sbjct: 1215 NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 69.3 bits (168), Expect = 7e-12
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 61/239 (25%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG--Y 205
+ + P + C G+ + + C D+DEC + NCR + VC N RG + C C P Y
Sbjct: 1011 VNTQPGYECYCKQGFYYDGNLLECVDVDECLDES-NCR-NGVCENTRGGYRCACTPPAEY 1068
Query: 206 QKRGEQCVDIDECTIPPYCHQRCVNTPGS-------------------------FYCQCS 240
QC+ +E P C + G + QC
Sbjct: 1069 SPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCR 1128
Query: 241 PGFQLAANNYTCVDINECDA----------------------SNQC---AQQCYNILGSF 275
P A ++ +E ++ S++C + +C G
Sbjct: 1129 PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGA 1188
Query: 276 ICQCNQGYELSSDRLNCEDIDECR---TSSYLCQYQ-CVNEPGKFSCMCPQGYQVVRSR 330
+C+C G++L + R C DIDECR LC+ + CVN G F C+C G+ RSR
Sbjct: 1189 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF--ARSR 1245
Score = 59.7 bits (143), Expect = 6e-09
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 193 LRGSFACQCPPGYQK-RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNY 250
+RG CP GY++ C DI+EC +P C H C+N PGS+ C C PG L +
Sbjct: 333 VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392
Query: 251 TCVDINECDAS---------NQCAQQCYNILGSFICQCNQG 282
C+ + S +QC L +C C+ G
Sbjct: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 53.5 bits (127), Expect = 4e-07
Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 31/142 (21%)
Query: 271 ILGSFICQCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
+ G C QGY+ RLN C+DI+EC C+N PG + C+CP G+ +
Sbjct: 333 VRGEVGADCPQGYK----RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388
Query: 328 RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCR 387
SRT +C ++ E +C+ +++PE++C P++ + R
Sbjct: 389 PSRT-----QC-IADKPEEKSLCFR-----------------LVSPEHQCQHPLTTRLTR 425
Query: 388 ELPQSIVYKYMSIRSDRSVPSD 409
+L V K R R P+D
Sbjct: 426 QLCCCSVGKAWGARCQR-CPTD 446
Score = 42.7 bits (99), Expect = 7e-04
Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 27/168 (16%)
Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRC-------VNTPGSFY----CQCSPGFQLAANNYT 251
PG K+ + C I CH +C V PG C G++ N+
Sbjct: 295 PGLTKQEDCCGSIGTAWGQSKCH-KCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTH 352
Query: 252 CVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC-----EDIDEC---RTSS 302
C DINEC C C N GS+ C C G+ L R C E+ C +
Sbjct: 353 CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPE 412
Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
+ CQ+ + C C G CQ C T E+C
Sbjct: 413 HQCQHPLTTRLTRQLCCCSVG--KAWGARCQ---RCPTDGTAAFKEIC 455
Score = 42.7 bits (99), Expect = 7e-04
Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)
Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
C GY++ CQDI+EC A CR C+N GS+ C CPPG+
Sbjct: 341 CPQGYKRLNSTHCQDINEC-AMPGVCRHGD-CLNNPGSYRCVCPPGH 385
Score = 34.7 bits (78), Expect = 0.20
Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLCLPK 73
+C G++ D R +C DIDEC + CK +CVN G + C+ K
Sbjct: 1191 ECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGSFRCVCK 1238
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 158 bits (400), Expect = 9e-39
Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
C G+ P +C D+DEC VP C G +C N G + C+ P+ A+ +
Sbjct: 505 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 563
Query: 81 NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+E P + E T G+ V A A P G GR
Sbjct: 564 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 619
Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
+ +P S R C AG+ S +D+DEC C + C N GS
Sbjct: 620 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 665
Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
F C CP G++ R G C D+DEC + PP + RC NT GSF C C GFQ C
Sbjct: 666 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 725
Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
D++EC+ C Q+C N GSF C+ C G+ L R C D+DEC + + C
Sbjct: 726 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 783
Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
C N G F C C GY+ R C D+NEC + C C N G F C C
Sbjct: 784 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 839
Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
Y P V +L QS
Sbjct: 840 PGYRPGPRGASCLDVDECSEEDLCQS 865
Score = 155 bits (392), Expect = 8e-38
Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ C+D+DEC P C G +C N G + C + QP
Sbjct: 670 CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 722
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
E + + G +G + GR V + P
Sbjct: 723 SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 778
Query: 149 IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
P + S R CA GY C D++EC G C C+N GSFAC
Sbjct: 779 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 837
Query: 201 CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
C PGY+ RG C+D+DEC+ C C NT GSF C C PG + + +C+D++E
Sbjct: 838 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 897
Query: 258 C--------------------------------------DASNQC---------AQQCYN 270
C D ++C AQ+C N
Sbjct: 898 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 957
Query: 271 ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
GS+ C C+ GY+ + C+D+DECR S+ + C N PG F C+C QGY+
Sbjct: 958 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016
Query: 328 R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
R R C D+NECET +C N G F C P +P + DP RCV P ++A
Sbjct: 1017 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1072
Score = 154 bits (390), Expect = 1e-37
Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
C G+ P +C D+DEC VP C G +C N G +LC+ P Q + Q
Sbjct: 547 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 605
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ + G LPG A G + + P P
Sbjct: 606 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 657
Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
R + S C AG+ CQD+DEC C + C N GSF C CP G+
Sbjct: 658 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 716
Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
Q G +C D+DEC C Q CVN+PGSF C+ C G L + C D++EC +
Sbjct: 717 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 774
Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
+ C C N GSF C C GY S R C D++EC + + +C+N G F
Sbjct: 775 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 834
Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
+C C GY+ R +C D++EC + C + +C N G F C
Sbjct: 835 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 877
Score = 153 bits (387), Expect = 3e-37
Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)
Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
S A GPE+ ++G ++ + +RNP P R S PS + C +G+ S C D+D
Sbjct: 463 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 522
Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
EC C + C N GSF C C PG++ R +C+D+DEC +PP C RC NT
Sbjct: 523 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 581
Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
PGSF C C G+Q A + +C D++EC S
Sbjct: 582 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 641
Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
++CAQ+ C N GSF C C G+ C+D+DEC S C Y +C
Sbjct: 642 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 701
Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
N G F C+CP G+Q C+D++ECE C E C N G F+C
Sbjct: 702 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 751
Score = 73.6 bits (179), Expect = 4e-13
Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
C GYE + C D++EC+ + C G C N G +LC+
Sbjct: 1009 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1067
Query: 72 PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
P+T+ QPQ P + S G + G G A P+
Sbjct: 1068 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1126
Query: 132 TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
++ RN + + RIQ G E +E+ ++C
Sbjct: 1127 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1182
Query: 172 --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
+D+DEC VC+N ++C C GY + +C+D DEC P C
Sbjct: 1183 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1242
Query: 227 -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
RCVNT GS++C C P L + CV NE + + C+ +G+
Sbjct: 1243 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1290
Score = 69.3 bits (168), Expect = 7e-12
Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
C G+ P C D+DEC A G +C N G Y C+ T
Sbjct: 879 CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 938
Query: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
+ ++ E A+ T G + G PGGG ++ RN
Sbjct: 939 VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 988
Query: 136 NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
+ A Q +P S + C GYE + + C D++EC C A +C N+
Sbjct: 989 RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1044
Query: 195 GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
GSF C CP PG Q + + PP +R +T
Sbjct: 1045 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1103
Query: 232 P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
P GS +C +P + A N T C + E S QQC +
Sbjct: 1104 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1163
Query: 275 --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
+C +GY S L+ D+DEC+ +C+ CVN +SC C GY
Sbjct: 1164 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1223
Query: 330 R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
R C D +EC E C N G + C C+ P +L + RCV S ++
Sbjct: 1224 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1277
Score = 68.2 bits (165), Expect = 2e-11
Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)
Query: 120 ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
+ A A GP + + RR+ +P+ P S+ A YE+ E C +D CT
Sbjct: 1419 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1478
Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
G C+ + F C+C GY+ CVDI+EC P C + RC+NT
Sbjct: 1479 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1530
Query: 233 GSFYCQCSPGFQLAANNYTC 252
GSF C C PGF + C
Sbjct: 1531 GSFRCICRPGFAPTHQPHHC 1550
Score = 64.3 bits (155), Expect = 2e-10
Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 195 GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
GS+A Y++ E+C +D CT + RCV P F C+C G++L CV
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1506
Query: 254 DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
DINECD AS C +C N GSF C C G+ + +C
Sbjct: 1507 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)
Query: 247 ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
A Y ++ EC + C +C + F C+C GY L R+ C DI+EC +S
Sbjct: 1459 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1518
Query: 303 YLC-QYQCVNEPGKFSCMCPQGY 324
LC +C+N G F C+C G+
Sbjct: 1519 PLCVNARCLNTDGSFRCICRPGF 1541
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)
Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
G H+C Q+C G+ CP G+++ C D+DEC C H C NT
Sbjct: 253 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 309
Query: 233 GSFYCQCSPGFQLAANNYTCV 253
G + C C GF L ++ +C+
Sbjct: 310 GGYTCVCPDGFLLDSSRSSCI 330
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
C G+E + +CED+DEC T +C N G ++C+CP G+ + SR+
Sbjct: 277 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 327
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)
Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
+ +EC +CV P F+C C GY++ +R C DINEC E + +
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525
Query: 350 CWNYHGGFRCYPR---NPCQDPYILTP 373
C N G FRC R P P+ P
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHCAP 1552
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
C GF+ N +C D++EC +C +C N G + C C G+ L S R +C
Sbjct: 277 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 41.2 bits (95), Expect = 0.002
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
C G+E+ + C+D+DEC G C+ + C N RG + C CP G+
Sbjct: 277 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 320
Score = 40.4 bits (93), Expect = 0.004
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
CP G++ V +C+D++EC T C+ E C N GG+ C C D ++L
Sbjct: 277 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 322
Score = 35.8 bits (81), Expect = 0.091
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
+C DGY D R C DI+ECD A +C+N G + C+
Sbjct: 1491 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536
Score = 32.3 bits (72), Expect = 1.0
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
C G+E V C+D+DEC C+ G +C N GGY C+
Sbjct: 277 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 315
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 158 bits (400), Expect = 9e-39
Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
C G+ P +C D+DEC VP C G +C N G + C+ P+ A+ +
Sbjct: 535 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 593
Query: 81 NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+E P + E T G+ V A A P G GR
Sbjct: 594 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 649
Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
+ +P S R C AG+ S +D+DEC C + C N GS
Sbjct: 650 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 695
Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
F C CP G++ R G C D+DEC + PP + RC NT GSF C C GFQ C
Sbjct: 696 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 755
Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
D++EC+ C Q+C N GSF C+ C G+ L R C D+DEC + + C
Sbjct: 756 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 813
Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
C N G F C C GY+ R C D+NEC + C C N G F C C
Sbjct: 814 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 869
Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
Y P V +L QS
Sbjct: 870 PGYRPGPRGASCLDVDECSEEDLCQS 895
Score = 155 bits (392), Expect = 8e-38
Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ C+D+DEC P C G +C N G + C + QP
Sbjct: 700 CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 752
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
E + + G +G + GR V + P
Sbjct: 753 SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 808
Query: 149 IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
P + S R CA GY C D++EC G C C+N GSFAC
Sbjct: 809 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 867
Query: 201 CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
C PGY+ RG C+D+DEC+ C C NT GSF C C PG + + +C+D++E
Sbjct: 868 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 927
Query: 258 C--------------------------------------DASNQC---------AQQCYN 270
C D ++C AQ+C N
Sbjct: 928 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 987
Query: 271 ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
GS+ C C+ GY+ + C+D+DECR S+ + C N PG F C+C QGY+
Sbjct: 988 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1046
Query: 328 R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
R R C D+NECET +C N G F C P +P + DP RCV P ++A
Sbjct: 1047 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1102
Score = 154 bits (390), Expect = 1e-37
Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
C G+ P +C D+DEC VP C G +C N G +LC+ P Q + Q
Sbjct: 577 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 635
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ + G LPG A G + + P P
Sbjct: 636 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 687
Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
R + S C AG+ CQD+DEC C + C N GSF C CP G+
Sbjct: 688 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 746
Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
Q G +C D+DEC C Q CVN+PGSF C+ C G L + C D++EC +
Sbjct: 747 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 804
Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
+ C C N GSF C C GY S R C D++EC + + +C+N G F
Sbjct: 805 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 864
Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
+C C GY+ R +C D++EC + C + +C N G F C
Sbjct: 865 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 907
Score = 153 bits (387), Expect = 3e-37
Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)
Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
S A GPE+ ++G ++ + +RNP P R S PS + C +G+ S C D+D
Sbjct: 493 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 552
Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
EC C + C N GSF C C PG++ R +C+D+DEC +PP C RC NT
Sbjct: 553 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 611
Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
PGSF C C G+Q A + +C D++EC S
Sbjct: 612 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 671
Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
++CAQ+ C N GSF C C G+ C+D+DEC S C Y +C
Sbjct: 672 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 731
Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
N G F C+CP G+Q C+D++ECE C E C N G F+C
Sbjct: 732 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 781
Score = 73.6 bits (179), Expect = 4e-13
Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
C GYE + C D++EC+ + C G C N G +LC+
Sbjct: 1039 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1097
Query: 72 PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
P+T+ QPQ P + S G + G G A P+
Sbjct: 1098 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1156
Query: 132 TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
++ RN + + RIQ G E +E+ ++C
Sbjct: 1157 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1212
Query: 172 --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
+D+DEC VC+N ++C C GY + +C+D DEC P C
Sbjct: 1213 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1272
Query: 227 -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
RCVNT GS++C C P L + CV NE + + C+ +G+
Sbjct: 1273 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1320
Score = 69.3 bits (168), Expect = 7e-12
Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
C G+ P C D+DEC A G +C N G Y C+ T
Sbjct: 909 CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 968
Query: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
+ ++ E A+ T G + G PGGG ++ RN
Sbjct: 969 VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 1018
Query: 136 NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
+ A Q +P S + C GYE + + C D++EC C A +C N+
Sbjct: 1019 RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1074
Query: 195 GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
GSF C CP PG Q + + PP +R +T
Sbjct: 1075 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1133
Query: 232 P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
P GS +C +P + A N T C + E S QQC +
Sbjct: 1134 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1193
Query: 275 --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
+C +GY S L+ D+DEC+ +C+ CVN +SC C GY
Sbjct: 1194 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1253
Query: 330 R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
R C D +EC E C N G + C C+ P +L + RCV S ++
Sbjct: 1254 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1307
Score = 68.2 bits (165), Expect = 2e-11
Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)
Query: 120 ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
+ A A GP + + RR+ +P+ P S+ A YE+ E C +D CT
Sbjct: 1449 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1508
Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
G C+ + F C+C GY+ CVDI+EC P C + RC+NT
Sbjct: 1509 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1560
Query: 233 GSFYCQCSPGFQLAANNYTC 252
GSF C C PGF + C
Sbjct: 1561 GSFRCICRPGFAPTHQPHHC 1580
Score = 64.3 bits (155), Expect = 2e-10
Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 195 GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
GS+A Y++ E+C +D CT + RCV P F C+C G++L CV
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1536
Query: 254 DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
DINECD AS C +C N GSF C C G+ + +C
Sbjct: 1537 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)
Query: 247 ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
A Y ++ EC + C +C + F C+C GY L R+ C DI+EC +S
Sbjct: 1489 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1548
Query: 303 YLC-QYQCVNEPGKFSCMCPQGY 324
LC +C+N G F C+C G+
Sbjct: 1549 PLCVNARCLNTDGSFRCICRPGF 1571
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)
Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
G H+C Q+C G+ CP G+++ C D+DEC C H C NT
Sbjct: 283 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 339
Query: 233 GSFYCQCSPGFQLAANNYTCV 253
G + C C GF L ++ +C+
Sbjct: 340 GGYTCVCPDGFLLDSSRSSCI 360
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
C G+E + +CED+DEC T +C N G ++C+CP G+ + SR+
Sbjct: 307 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 357
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)
Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
+ +EC +CV P F+C C GY++ +R C DINEC E + +
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555
Query: 350 CWNYHGGFRCYPR---NPCQDPYILTP 373
C N G FRC R P P+ P
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHCAP 1582
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
C GF+ N +C D++EC +C +C N G + C C G+ L S R +C
Sbjct: 307 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 41.2 bits (95), Expect = 0.002
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
C G+E+ + C+D+DEC G C+ + C N RG + C CP G+
Sbjct: 307 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 350
Score = 40.4 bits (93), Expect = 0.004
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
CP G++ V +C+D++EC T C+ E C N GG+ C C D ++L
Sbjct: 307 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 352
Score = 35.8 bits (81), Expect = 0.091
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
+C DGY D R C DI+ECD A +C+N G + C+
Sbjct: 1521 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566
Score = 32.3 bits (72), Expect = 1.0
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
C G+E V C+D+DEC C+ G +C N GGY C+
Sbjct: 307 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 345
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 158 bits (400), Expect = 9e-39
Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
C G+ P +C D+DEC VP C G +C N G + C+ P+ A+ +
Sbjct: 572 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 630
Query: 81 NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
+E P + E T G+ V A A P G GR
Sbjct: 631 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 686
Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
+ +P S R C AG+ S +D+DEC C + C N GS
Sbjct: 687 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 732
Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
F C CP G++ R G C D+DEC + PP + RC NT GSF C C GFQ C
Sbjct: 733 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 792
Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
D++EC+ C Q+C N GSF C+ C G+ L R C D+DEC + + C
Sbjct: 793 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 850
Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
C N G F C C GY+ R C D+NEC + C C N G F C C
Sbjct: 851 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 906
Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
Y P V +L QS
Sbjct: 907 PGYRPGPRGASCLDVDECSEEDLCQS 932
Score = 155 bits (392), Expect = 8e-38
Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C G+ C+D+DEC P C G +C N G + C + QP
Sbjct: 737 CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 789
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
E + + G +G + GR V + P
Sbjct: 790 SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 845
Query: 149 IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
P + S R CA GY C D++EC G C C+N GSFAC
Sbjct: 846 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 904
Query: 201 CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
C PGY+ RG C+D+DEC+ C C NT GSF C C PG + + +C+D++E
Sbjct: 905 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 964
Query: 258 C--------------------------------------DASNQC---------AQQCYN 270
C D ++C AQ+C N
Sbjct: 965 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 1024
Query: 271 ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
GS+ C C+ GY+ + C+D+DECR S+ + C N PG F C+C QGY+
Sbjct: 1025 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1083
Query: 328 R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
R R C D+NECET +C N G F C P +P + DP RCV P ++A
Sbjct: 1084 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1139
Score = 154 bits (390), Expect = 1e-37
Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
C G+ P +C D+DEC VP C G +C N G +LC+ P Q + Q
Sbjct: 614 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 672
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
+ + G LPG A G + + P P
Sbjct: 673 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 724
Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
R + S C AG+ CQD+DEC C + C N GSF C CP G+
Sbjct: 725 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 783
Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
Q G +C D+DEC C Q CVN+PGSF C+ C G L + C D++EC +
Sbjct: 784 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 841
Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
+ C C N GSF C C GY S R C D++EC + + +C+N G F
Sbjct: 842 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 901
Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
+C C GY+ R +C D++EC + C + +C N G F C
Sbjct: 902 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 944
Score = 153 bits (387), Expect = 3e-37
Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)
Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
S A GPE+ ++G ++ + +RNP P R S PS + C +G+ S C D+D
Sbjct: 530 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 589
Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
EC C + C N GSF C C PG++ R +C+D+DEC +PP C RC NT
Sbjct: 590 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 648
Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
PGSF C C G+Q A + +C D++EC S
Sbjct: 649 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 708
Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
++CAQ+ C N GSF C C G+ C+D+DEC S C Y +C
Sbjct: 709 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 768
Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
N G F C+CP G+Q C+D++ECE C E C N G F+C
Sbjct: 769 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 818
Score = 73.6 bits (179), Expect = 4e-13
Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
C GYE + C D++EC+ + C G C N G +LC+
Sbjct: 1076 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1134
Query: 72 PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
P+T+ QPQ P + S G + G G A P+
Sbjct: 1135 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1193
Query: 132 TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
++ RN + + RIQ G E +E+ ++C
Sbjct: 1194 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1249
Query: 172 --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
+D+DEC VC+N ++C C GY + +C+D DEC P C
Sbjct: 1250 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1309
Query: 227 -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
RCVNT GS++C C P L + CV NE + + C+ +G+
Sbjct: 1310 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1357
Score = 69.3 bits (168), Expect = 7e-12
Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
C G+ P C D+DEC A G +C N G Y C+ T
Sbjct: 946 CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 1005
Query: 78 IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
+ ++ E A+ T G + G PGGG ++ RN
Sbjct: 1006 VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 1055
Query: 136 NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
+ A Q +P S + C GYE + + C D++EC C A +C N+
Sbjct: 1056 RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1111
Query: 195 GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
GSF C CP PG Q + + PP +R +T
Sbjct: 1112 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1170
Query: 232 P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
P GS +C +P + A N T C + E S QQC +
Sbjct: 1171 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1230
Query: 275 --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
+C +GY S L+ D+DEC+ +C+ CVN +SC C GY
Sbjct: 1231 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1290
Query: 330 R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
R C D +EC E C N G + C C+ P +L + RCV S ++
Sbjct: 1291 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1344
Score = 68.2 bits (165), Expect = 2e-11
Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)
Query: 120 ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
+ A A GP + + RR+ +P+ P S+ A YE+ E C +D CT
Sbjct: 1486 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1545
Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
G C+ + F C+C GY+ CVDI+EC P C + RC+NT
Sbjct: 1546 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1597
Query: 233 GSFYCQCSPGFQLAANNYTC 252
GSF C C PGF + C
Sbjct: 1598 GSFRCICRPGFAPTHQPHHC 1617
Score = 64.3 bits (155), Expect = 2e-10
Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 195 GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
GS+A Y++ E+C +D CT + RCV P F C+C G++L CV
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1573
Query: 254 DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
DINECD AS C +C N GSF C C G+ + +C
Sbjct: 1574 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)
Query: 247 ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
A Y ++ EC + C +C + F C+C GY L R+ C DI+EC +S
Sbjct: 1526 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1585
Query: 303 YLC-QYQCVNEPGKFSCMCPQGY 324
LC +C+N G F C+C G+
Sbjct: 1586 PLCVNARCLNTDGSFRCICRPGF 1608
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)
Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
G H+C Q+C G+ CP G+++ C D+DEC C H C NT
Sbjct: 320 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 376
Query: 233 GSFYCQCSPGFQLAANNYTCV 253
G + C C GF L ++ +C+
Sbjct: 377 GGYTCVCPDGFLLDSSRSSCI 397
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
C G+E + +CED+DEC T +C N G ++C+CP G+ + SR+
Sbjct: 344 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 394
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)
Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
+ +EC +CV P F+C C GY++ +R C DINEC E + +
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592
Query: 350 CWNYHGGFRCYPR---NPCQDPYILTP 373
C N G FRC R P P+ P
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHCAP 1619
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
C GF+ N +C D++EC +C +C N G + C C G+ L S R +C
Sbjct: 344 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 41.2 bits (95), Expect = 0.002
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)
Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
C G+E+ + C+D+DEC G C+ + C N RG + C CP G+
Sbjct: 344 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 387
Score = 40.4 bits (93), Expect = 0.004
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)
Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
CP G++ V +C+D++EC T C+ E C N GG+ C C D ++L
Sbjct: 344 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 389
Score = 35.8 bits (81), Expect = 0.091
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
+C DGY D R C DI+ECD A +C+N G + C+
Sbjct: 1558 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603
Score = 32.3 bits (72), Expect = 1.0
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
C G+E V C+D+DEC C+ G +C N GGY C+
Sbjct: 344 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 382
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 144 bits (364), Expect = 1e-34
Identities = 75/205 (36%), Positives = 108/205 (52%), Gaps = 12/205 (5%)
Query: 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPG 233
C+ HNC CIN+ GS+ C+C GY +Q C D C + + C Q CVN PG
Sbjct: 242 CSTLEHNCA--HFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 234 SFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNC 292
SF CQC G+ LA + CV ++ C + N C +C N GS++CQC++G+ L+ D+ C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 293 EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCW 351
ID C +S++ CQ++CVN +SC C +G+ + +TC+ IN C E E C
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-CV 418
Query: 352 NYHGGFRCYPRNPCQDPYILTPENR 376
N + C C Y L P +
Sbjct: 419 NMEESYYC----RCHRGYTLDPNGK 439
Score = 142 bits (359), Expect = 5e-34
Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 15/228 (6%)
Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
S+ +C GY S+ C+ D C HNC +Q+C+N+ GSF CQC GY + G+
Sbjct: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGK 316
Query: 211 QCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQC 268
+CV +D C + C CVN GS+ CQC GF L + TC I+ C +SN C +C
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-V 327
N S+ C C +G+ L+ D+ C I+ C + C+++CVN + C C +GY +
Sbjct: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436
Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
+TC ++ C + + C +++C N F C C + +++ +
Sbjct: 437 NGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC----QCSEGFLINED 478
Score = 136 bits (343), Expect = 4e-32
Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 15/235 (6%)
Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK 207
+ ++ S+ QC G+ + + C ID C + H C+ + C+N S++C C G+
Sbjct: 336 VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTL 393
Query: 208 RGEQ--CVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ- 263
++ C I+ C + P C CVN S+YC+C G+ L N TC ++ C +
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG 453
Query: 264 CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
C Q C N SF+CQC++G+ ++ D C +D C S + C+Y CVN F+C CP+G
Sbjct: 454 CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG 513
Query: 324 YQVVRS--RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
+ V+RS +TC ++ C + E C + F C C + YIL + +
Sbjct: 514 H-VLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVC----QCFEGYILREDGK 562
Score = 134 bits (336), Expect = 2e-31
Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 42/399 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
QC GY ++C +D C C+ +CVN G YLC + P ++
Sbjct: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFAL----NPDKK 357
Query: 88 TQP-----AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGR--NNFVIR 140
T A G V + L G P+ +T R N +
Sbjct: 358 TCTKIDYCASSNHGCQHECVNTDDSYSCHCLKG--------FTLNPDKKTCRRINYCALN 409
Query: 141 RNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFAC 199
+ + + + S+ +C GY + C +D C H C +Q+C+N SF C
Sbjct: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC 467
Query: 200 QCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
QC G+ + + C +D C + + C CVN SF CQC G L ++ TC ++
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527
Query: 257 ECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
C + C C + SF+CQC +GY L D C D C+ + C++ CVN
Sbjct: 528 SCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
Query: 316 FSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
++C C +G+++ + C+ + C++T+ E +C N + C C + ++L +
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYIC----KCSEGFVLAED 642
Query: 375 NRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQI 413
R C++ + + I +S+ + F++
Sbjct: 643 GR--------RCKKCTEGPIDLVFVIDGSKSLGEENFEV 673
Score = 86.3 bits (212), Expect = 6e-17
Identities = 45/132 (34%), Positives = 64/132 (48%), Gaps = 11/132 (8%)
Query: 262 NQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
+ CA C NI GS++C+C QGY L+SD+ C D C + C+ CVN PG F C C
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306
Query: 322 QGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC--- 377
GY + + C ++ C + N E E C N G + C C + + L P+ +
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLC----QCHEGFALNPDKKTCTK 361
Query: 378 --VCPVSNAMCR 387
C SN C+
Sbjct: 362 IDYCASSNHGCQ 373
Score = 73.6 bits (179), Expect = 4e-13
Identities = 67/276 (24%), Positives = 109/276 (39%), Gaps = 53/276 (19%)
Query: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
Y +C GY DP + C +D C C+ C+N ++C + ++ + NE +
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLK 480
Query: 86 QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
T V ++ G + + A PE V+R +
Sbjct: 481 ------------TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE------GHVLRSDGKT 522
Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
++ S CA G EH+ C++ SF CQC GY
Sbjct: 523 CAKLDS-------CALGDHGCEHS--------------------CVSSEDSFVCQCFEGY 555
Query: 206 --QKRGEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
++ G+ C D C I C CVN+ S+ C+C GF+LA + C + C +++
Sbjct: 556 ILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
Query: 263 Q-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
C C N S+IC+C++G+ L+ D C+ E
Sbjct: 616 HGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 144 bits (364), Expect = 1e-34
Identities = 75/205 (36%), Positives = 108/205 (52%), Gaps = 12/205 (5%)
Query: 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPG 233
C+ HNC CIN+ GS+ C+C GY +Q C D C + + C Q CVN PG
Sbjct: 242 CSTLEHNCA--HFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
Query: 234 SFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNC 292
SF CQC G+ LA + CV ++ C + N C +C N GS++CQC++G+ L+ D+ C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
Query: 293 EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCW 351
ID C +S++ CQ++CVN +SC C +G+ + +TC+ IN C E E C
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-CV 418
Query: 352 NYHGGFRCYPRNPCQDPYILTPENR 376
N + C C Y L P +
Sbjct: 419 NMEESYYC----RCHRGYTLDPNGK 439
Score = 142 bits (359), Expect = 5e-34
Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 15/228 (6%)
Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
S+ +C GY S+ C+ D C HNC +Q+C+N+ GSF CQC GY + G+
Sbjct: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGK 316
Query: 211 QCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQC 268
+CV +D C + C CVN GS+ CQC GF L + TC I+ C +SN C +C
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-V 327
N S+ C C +G+ L+ D+ C I+ C + C+++CVN + C C +GY +
Sbjct: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436
Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
+TC ++ C + + C +++C N F C C + +++ +
Sbjct: 437 NGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC----QCSEGFLINED 478
Score = 136 bits (343), Expect = 4e-32
Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 15/235 (6%)
Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK 207
+ ++ S+ QC G+ + + C ID C + H C+ + C+N S++C C G+
Sbjct: 336 VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTL 393
Query: 208 RGEQ--CVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ- 263
++ C I+ C + P C CVN S+YC+C G+ L N TC ++ C +
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG 453
Query: 264 CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
C Q C N SF+CQC++G+ ++ D C +D C S + C+Y CVN F+C CP+G
Sbjct: 454 CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG 513
Query: 324 YQVVRS--RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
+ V+RS +TC ++ C + E C + F C C + YIL + +
Sbjct: 514 H-VLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVC----QCFEGYILREDGK 562
Score = 134 bits (336), Expect = 2e-31
Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 42/399 (10%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
QC GY ++C +D C C+ +CVN G YLC + P ++
Sbjct: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFAL----NPDKK 357
Query: 88 TQP-----AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGR--NNFVIR 140
T A G V + L G P+ +T R N +
Sbjct: 358 TCTKIDYCASSNHGCQHECVNTDDSYSCHCLKG--------FTLNPDKKTCRRINYCALN 409
Query: 141 RNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFAC 199
+ + + + S+ +C GY + C +D C H C +Q+C+N SF C
Sbjct: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC 467
Query: 200 QCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
QC G+ + + C +D C + + C CVN SF CQC G L ++ TC ++
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527
Query: 257 ECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
C + C C + SF+CQC +GY L D C D C+ + C++ CVN
Sbjct: 528 SCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
Query: 316 FSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
++C C +G+++ + C+ + C++T+ E +C N + C C + ++L +
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYIC----KCSEGFVLAED 642
Query: 375 NRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQI 413
R C++ + + I +S+ + F++
Sbjct: 643 GR--------RCKKCTEGPIDLVFVIDGSKSLGEENFEV 673
Score = 86.3 bits (212), Expect = 6e-17
Identities = 45/132 (34%), Positives = 64/132 (48%), Gaps = 11/132 (8%)
Query: 262 NQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
+ CA C NI GS++C+C QGY L+SD+ C D C + C+ CVN PG F C C
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306
Query: 322 QGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC--- 377
GY + + C ++ C + N E E C N G + C C + + L P+ +
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLC----QCHEGFALNPDKKTCTK 361
Query: 378 --VCPVSNAMCR 387
C SN C+
Sbjct: 362 IDYCASSNHGCQ 373
Score = 73.6 bits (179), Expect = 4e-13
Identities = 67/276 (24%), Positives = 109/276 (39%), Gaps = 53/276 (19%)
Query: 26 YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
Y +C GY DP + C +D C C+ C+N ++C + ++ + NE +
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLK 480
Query: 86 QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
T V ++ G + + A PE V+R +
Sbjct: 481 ------------TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE------GHVLRSDGKT 522
Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
++ S CA G EH+ C++ SF CQC GY
Sbjct: 523 CAKLDS-------CALGDHGCEHS--------------------CVSSEDSFVCQCFEGY 555
Query: 206 --QKRGEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
++ G+ C D C I C CVN+ S+ C+C GF+LA + C + C +++
Sbjct: 556 ILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
Query: 263 Q-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
C C N S+IC+C++G+ L+ D C+ E
Sbjct: 616 HGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 137 bits (345), Expect = 2e-32
Identities = 75/226 (33%), Positives = 112/226 (49%), Gaps = 18/226 (7%)
Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPY---CHQRCV 229
D+DEC+ GT +C D +C N S+ C C PGY+ G+QC DIDEC Y C C+
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92
Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSD 288
N PG++ C C GF LA + + C+D++EC D + C Q C N +GS+ CQC+ G+ LS +
Sbjct: 93 NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDN 152
Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSRTCQDINECETTNE 343
+ C + C + C + C P G +C C G+ + +++ +
Sbjct: 153 QHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGG 212
Query: 344 CREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV--CPVSNAMC 386
C+ C + G C C Y L + R C+ C V+N C
Sbjct: 213 CQHS--CEDTDTGPTC----GCHQKYALHSDGRTCIETCAVNNGGC 252
Score = 133 bits (335), Expect = 3e-31
Identities = 91/336 (27%), Positives = 142/336 (42%), Gaps = 15/336 (4%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGM--KCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
C GY+ + +QC+DIDEC+ D GG +C+N G Y C ++ ++
Sbjct: 61 CKPGYKGEG--KQCEDIDECE--NDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
+ + +G + + + G F++ G N A
Sbjct: 117 DVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI 176
Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
R C G++ +++ + C G C+ C + C C Y
Sbjct: 177 CRETPKGGVACDCRPGFDLAQNQKDCTL-TCNYGNGGCQ--HSCEDTDTGPTCGCHQKYA 233
Query: 207 KRGEQCVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN-QC 264
+ I+ C + C + C +T C C GF L + TC DINEC +N C
Sbjct: 234 LHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC 293
Query: 265 AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
C N +GSF C C +GY+L +D C+DIDEC + C + C+N PG F C+C +GY
Sbjct: 294 DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCDHICINSPGSFQCLCHRGY 352
Query: 325 QVVRSRTCQDINECETTN-ECREDEMCWNYHGGFRC 359
+ + C D++EC +N C D+ C N G + C
Sbjct: 353 ILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYEC 386
Score = 115 bits (289), Expect = 7e-26
Identities = 94/321 (29%), Positives = 134/321 (41%), Gaps = 63/321 (19%)
Query: 106 SMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQ 165
++ T G L GG + + V E G ++ I A Q P S++ C GY+
Sbjct: 15 ALGTRGRLAGGSGLPGSVDV--DECSEGTDDCHI---DAICQNTPK--SYKCLCKPGYK- 66
Query: 166 SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPP 222
E C+DIDEC +N CIN+ G++ C C G+ G C+D+DEC
Sbjct: 67 GEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNG 126
Query: 223 YCHQRCVNTPGSFYCQCSPGFQLAANNYTCV-----DINECDASNQCAQQCYNI-LGSFI 276
C Q CVN GS+ CQC GF L+ N +TC+ +N + + CA C G
Sbjct: 127 GCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA 186
Query: 277 CQCNQGYELSSDRL---------------NCED----------------------IDECR 299
C C G++L+ ++ +CED I+ C
Sbjct: 187 CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCA 246
Query: 300 TSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTN-ECREDEMCWNYHGGF 357
++ C C + C CP G+ + +TC+DINEC N C D C N G F
Sbjct: 247 VNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSF 304
Query: 358 RCYPRNPCQDPY-ILTPENRC 377
C C+ Y +LT E C
Sbjct: 305 EC----GCRKGYKLLTDERTC 321
Score = 53.9 bits (128), Expect = 3e-07
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 4/72 (5%)
Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK- 207
I S S + C GY C D+DEC+ +C DQ C+N +GS+ C CPPG +
Sbjct: 338 INSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECVCPPGRRLH 395
Query: 208 -RGEQCVDIDEC 218
G+ CV+ +C
Sbjct: 396 WNGKDCVETGKC 407
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 135 bits (339), Expect = 1e-31
Identities = 77/232 (33%), Positives = 115/232 (49%), Gaps = 29/232 (12%)
Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPY--CHQRCV 229
QD+DEC GT NC D +C N S+ C C GY G+ C D+DEC C CV
Sbjct: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCV 87
Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSD 288
N PG++ C C GF LA + + C+D++EC + + C Q C N++GS+ C C +G+ LS +
Sbjct: 88 NIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDN 147
Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSR-----TCQDIN-E 337
+ C E+ C ++ C + C P G +C C G+++ +++ TC N
Sbjct: 148 QHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGG 207
Query: 338 CETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-TPENRCV--CPVSNAMC 386
C+ T C + E PR C ++L T C+ C V+N C
Sbjct: 208 CQHT--CDDTEQ----------GPRCGCHIKFVLHTDGKTCIETCAVNNGGC 247
Score = 129 bits (325), Expect = 5e-30
Identities = 91/296 (30%), Positives = 124/296 (41%), Gaps = 64/296 (21%)
Query: 145 DPQRIPSNPSHRIQCAAGYEQSE--HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
D IP N +R C G+ + HN C D+DEC G C+ Q C+N+ GS+ C C
Sbjct: 85 DCVNIPGN--YRCTCYDGFHLAHDGHN-CLDVDECAEGNGGCQ--QSCVNMMGSYECHCR 139
Query: 203 PGYQKRGEQ--CVDIDE----CTIPPY-CHQRCVNTP-GSFYCQCSPGFQLAANN----- 249
G+ Q C+ E C + C C TP G C+C PGF+L N
Sbjct: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199
Query: 250 ----------YTCVD----------------------INECDASNQ-CAQQCYNILGSFI 276
+TC D I C +N C +C++
Sbjct: 200 TCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVH 259
Query: 277 CQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQ-VVRSRTCQDI 335
C C G+ L DR C+DIDECR ++ C + C N G F C C +GY+ ++ R CQDI
Sbjct: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319
Query: 336 NECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC----VCPVSNAMCR 387
+EC C D +C N G F+C C Y+L C C ++ CR
Sbjct: 320 DECSFDRTC--DHICVNTPGSFQCL----CHRGYLLYGITHCGDVDECSINRGGCR 369
Score = 124 bits (312), Expect = 1e-28
Identities = 86/303 (28%), Positives = 126/303 (41%), Gaps = 21/303 (6%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C DG+ C D+DEC C+ CVN G Y C + + +N+ +
Sbjct: 97 CYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCREGFFLSDNQHTCIQ- 153
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP-- 146
+P EG + A + P GG G E+ + + + N +
Sbjct: 154 RPEEGMNCMNKNHGCAHICRET---PKGGIACECRP--GFELTKNQRDCKLTCNYGNGGC 208
Query: 147 QRIPSNPSHRIQCAAGYE---QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
Q + +C + ++ C I+ C C D C + C CP
Sbjct: 209 QHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGC--DSKCHDAATGVHCTCPV 264
Query: 204 GYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA 260
G+ + ++ C DIDEC + C C NT GSF C C G++L N C DI+EC
Sbjct: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF 324
Query: 261 SNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC 320
C C N GSF C C++GY L +C D+DEC + C++ C+N PG + C C
Sbjct: 325 DRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTC 383
Query: 321 PQG 323
P G
Sbjct: 384 PAG 386
Score = 120 bits (300), Expect = 4e-27
Identities = 97/339 (28%), Positives = 139/339 (41%), Gaps = 22/339 (6%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDA-CKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
C GY D + CKD+DEC+ +A C CVN G Y C + +
Sbjct: 57 CKSGYTGDG--KHCKDVDECEREDNAGCV--HDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112
Query: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVAS---AAAVAGPEMQTGRNNFVIRRNP 143
+ AEG G V + M + GF S + PE G N
Sbjct: 113 VDECAEGNGGCQQSCV--NMMGSYECHCREGFFLSDNQHTCIQRPE--EGMNCMNKNHGC 168
Query: 144 ADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
A R +C G+E +++ + C G C+ C + C C
Sbjct: 169 AHICRETPKGGIACECRPGFELTKNQRDCKL-TCNYGNGGCQ--HTCDDTEQGPRCGCHI 225
Query: 204 GYQKRGEQCVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
+ + I+ C + C +C + +C C GF L + TC DI+EC +N
Sbjct: 226 KFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNN 285
Query: 263 -QCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
C C N +GSF C C +GY+L + NC+DIDEC + C + CVN PG F C+C
Sbjct: 286 GGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCH 344
Query: 322 QGYQVVRSRTCQDINECE-TTNECREDEMCWNYHGGFRC 359
+GY + C D++EC CR C N G ++C
Sbjct: 345 RGYLLYGITHCGDVDECSINRGGCRFG--CINTPGSYQC 381
Score = 50.8 bits (120), Expect = 3e-06
Identities = 62/264 (23%), Positives = 89/264 (33%), Gaps = 73/264 (27%)
Query: 23 TITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNE 82
T + C G+ P R+ CKDIDEC + C C N G + C K ++ NE
Sbjct: 256 TGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINE 313
Query: 83 QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN 142
+ Q+ E + T + ++ PG
Sbjct: 314 RNCQDID--ECSFDRTCDHICVNT-------PG--------------------------- 337
Query: 143 PADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
S + C GY C D+DEC+ CR CIN GS+ C CP
Sbjct: 338 -----------SFQCLCHRGYLLYGITHCGDVDECSINRGGCRFG--CINTPGSYQCTCP 384
Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
G +G + +CT P CQ SPG A + N +
Sbjct: 385 AG---QGRLHWNGKDCTEP-------------LKCQGSPGASKA-----MLSCNRSGKKD 423
Query: 263 QCAQQCYNILGSFICQCNQGYELS 286
CA C + F+ + G+ +S
Sbjct: 424 TCALTCPS-RARFLPESENGFTVS 446
Score = 36.2 bits (82), Expect = 0.070
Identities = 29/115 (25%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 42 CKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVN-NEQPQQETQPAEGTSGATTG 100
C D+DEC I C+ G C+N G Y C Q ++ N + E +G+ GA+
Sbjct: 355 CGDVDECSINRGGCRFG--CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKA 412
Query: 101 VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH 155
+++ + SG + A PE + N F + P+ P+ H
Sbjct: 413 MLSCN---RSGKKDTCALTCPSRARFLPESE---NGFTVSCGTPSPRAAPARAGH 461
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 135 bits (339), Expect = 1e-31
Identities = 68/192 (35%), Positives = 96/192 (50%), Gaps = 12/192 (6%)
Query: 156 RIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQC 212
R +C GY+ ++ C+D+DEC AG C C+N +GSF C C GY+ G QC
Sbjct: 267 RCECHVGYQLAADGKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYELGADGRQC 324
Query: 213 VDIDECTIPPY------CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ 266
I+ + C C +T C C G++L + TC+D+++C S C Q
Sbjct: 325 YRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQ 384
Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV 326
C N G + C C GY LS+D CED+DEC +S C++ C N G F C C GY++
Sbjct: 385 VCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRL 444
Query: 327 VRSRT-CQDINE 337
R C + E
Sbjct: 445 HEDRRGCSPLEE 456
Score = 124 bits (312), Expect = 1e-28
Identities = 71/217 (32%), Positives = 107/217 (49%), Gaps = 14/217 (6%)
Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GE 210
S+ +C G+ ++ C I+ C G C+ V + + CQC PG+Q + G
Sbjct: 182 SYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTIT-RHRCQCRPGFQLQEDGR 240
Query: 211 QCVDIDECTIPP-YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS-NQCAQQC 268
CV C C RC G C+C G+QLAA+ C D++EC A QCA C
Sbjct: 241 HCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGC 300
Query: 269 YNILGSFICQCNQGYELSSD-----RLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
N GSF C C+ GYEL +D R+ E ++ C ++ C + C + C CP+G
Sbjct: 301 LNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG 360
Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
Y++ RTC D+++C + C+ ++C N GG+ C
Sbjct: 361 YELDTDQRTCIDVDDCADSPCCQ--QVCTNNPGGYEC 395
Score = 122 bits (307), Expect = 6e-28
Identities = 70/204 (34%), Positives = 100/204 (49%), Gaps = 20/204 (9%)
Query: 151 SNPSHRIQCAAGYEQSEHNVCQ-DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG 209
+ P H C G++ CQ D+DEC THN C+N GS+ C+C PG++
Sbjct: 144 AQPCH---CPPGFQGPR---CQYDVDECR--THNGGCQHRCVNTPGSYLCECKPGFRLHT 195
Query: 210 EQ--CVDIDECTIPPY-CHQRCVN-TPGSFYCQCSPGFQLAANNYTCVDINECDASN-QC 264
+ C+ I+ C + C CV T CQC PGFQL + CV + C N C
Sbjct: 196 DSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSC 255
Query: 265 AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
+C + G C+C+ GY+L++D CED+DEC C + C+N G F C+C GY
Sbjct: 256 MHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGY 315
Query: 325 QV-VRSRTC-----QDINECETTN 342
++ R C + +N CE N
Sbjct: 316 ELGADGRQCYRIEMEIVNSCEANN 339
Score = 68.6 bits (166), Expect = 1e-11
Identities = 81/365 (22%), Positives = 125/365 (34%), Gaps = 77/365 (21%)
Query: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
+C GY+ + C+D+DEC C G C+N G + C+ +
Sbjct: 269 ECHVGYQLAADGKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYEL--------- 317
Query: 88 TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
G G + + + GG + AGP
Sbjct: 318 -----GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP------------------- 353
Query: 148 RIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
C GYE ++ C D+D+C A + C+ QVC N G + C C GY+
Sbjct: 354 --------LCTCPRGYELDTDQRTCIDVDDC-ADSPCCQ--QVCTNNPGGYECGCYAGYR 402
Query: 207 KRGEQC--VDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE----CD 259
+ C D+DEC + C C N GSF C C G++L + C + E D
Sbjct: 403 LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 462
Query: 260 ASNQCAQQCYNI--LGSFICQCNQGYELSSDRLNCEDIDE-CRTSSYLCQYQCVNEP--- 313
+ +I L + Q Q ++ +D E E T ++C
Sbjct: 463 GELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSL 522
Query: 314 -------------GKFSCMCPQGYQ-VVRSRTCQDI---NECETTNECREDEMCWNYHGG 356
G C CP+G+ ++ + TC C + C+ C + G
Sbjct: 523 TCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGA 582
Query: 357 FRCYP 361
RC P
Sbjct: 583 CRCPP 587
Score = 48.1 bits (113), Expect = 2e-05
Identities = 70/277 (25%), Positives = 97/277 (35%), Gaps = 61/277 (22%)
Query: 154 SHRIQCAAGYEQSEHNVCQDIDE---CTAGTHNCRADQVCINLRGSFACQCPPGYQ-KRG 209
SH C+AG H C I C AG R +Q C +G F C Q + G
Sbjct: 870 SHPCNCSAG-----HGSCDAISGLCLCEAGYVGPRCEQQCP--QGHFGPGCEQRCQCQHG 922
Query: 210 EQCVDID-ECTIPP-----YCHQRCVNTPGSFY-------CQCSPGFQLAANNYTCVD-- 254
C + CT P +C C P F+ C C+ G A N +C+
Sbjct: 923 AACDHVSGACTCPAGWRGTFCEHAC---PAGFFGLDCRSACNCTAGAACDAVNGSCLCPA 979
Query: 255 -------INECDA---SNQCAQQCYNILGSFI------CQCNQGYELSSDRLNCEDI--- 295
C A + C+Q C G+ C C G+ S C
Sbjct: 980 GRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYG 1039
Query: 296 DECRTSSYLCQYQCVNEPGKFSCMCPQGYQ-VVRSRTC--QDINE-CETTNECREDEMCW 351
D CR S LCQ +P C CP+G+ + + C +D+ C + C +C
Sbjct: 1040 DNCRHSC-LCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCD 1098
Query: 352 NYHGGFRC---YPRNPCQDPYIL-----TPENRCVCP 380
+ G C + + CQ P + RC CP
Sbjct: 1099 PHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCP 1135
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/234 (23%), Positives = 82/234 (35%), Gaps = 44/234 (18%)
Query: 156 RIQCAAGYEQSEHNVCQD------IDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--- 206
R C AG+ + CQ E A +C C ++ G AC+CPPG+
Sbjct: 1103 RCLCPAGWTGDK---CQSPCLRGWFGEACAQRCSCPPGAACHHVTG--ACRCPPGFTGSG 1157
Query: 207 --------KRGEQCVDIDECT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
GE C + +C P CH P + C C+ G+ + C
Sbjct: 1158 CEQACPPGSFGEDCAQMCQCPGENPACH------PATGTCSCAAGYHGPSCQQRCPPGR- 1210
Query: 258 CDASNQCAQQCYNILG------SFICQCNQGYELSSDRLNCEDIDECRTSSYL--CQYQC 309
C Q C + G + C+C G+ + L C +++ C
Sbjct: 1211 --YGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA 1268
Query: 310 VNEPGKFSCMCPQGYQVVR-SRTCQDIN---ECETTNECREDEMCWNYHGGFRC 359
+P +C+CP G VR R C CE T CR +C +G C
Sbjct: 1269 ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSC 1322
Score = 40.0 bits (92), Expect = 0.005
Identities = 58/237 (24%), Positives = 80/237 (33%), Gaps = 54/237 (22%)
Query: 158 QCAAGYEQSEHNVCQDIDECTAGTH--NCRAD-----QVCINLRGSFACQCPPGYQKRGE 210
+C AG++ + EC GT NC + C + G C+CPPG + GE
Sbjct: 717 RCPAGFQGEDCG-----QECPVGTFGVNCSSSCSCGGAPCHGVTGQ--CRCPPG--RTGE 767
Query: 211 QC-VDIDE------CT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI------- 255
C D E C I P C P + C C PGF C D+
Sbjct: 768 DCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFV----GSRCQDVCPAGWYG 823
Query: 256 NECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEP 313
C CA C+ G C C G+ +C+ + C + C
Sbjct: 824 PSCQTRCSCANDGHCHPATGH--CSCAPGW----TGFSCQRACDTGHWGPDCSHPCNCSA 877
Query: 314 GKFS-------CMCPQGYQVVR-SRTCQDIN---ECETTNECREDEMCWNYHGGFRC 359
G S C+C GY R + C + CE +C+ C + G C
Sbjct: 878 GHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTC 934
Score = 38.9 bits (89), Expect = 0.011
Identities = 48/191 (25%), Positives = 67/191 (35%), Gaps = 46/191 (24%)
Query: 157 IQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFAC-----------QCPPG 204
++C G Q+ V C+ T +CR +C GS +C CPPG
Sbjct: 1286 VRCERGCPQNRFGVGCEH-------TCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPG 1338
Query: 205 YQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC-VDINECDASNQ 263
+ G C EC+ CH P + C+C PGF A + C +
Sbjct: 1339 --RYGAACHL--ECS----CHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGL 1390
Query: 264 CAQQ----CYNILGSFICQ-------CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE 312
C Q C I G +C C +G E S C +C + C +
Sbjct: 1391 CWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGA-----PC--D 1443
Query: 313 PGKFSCMCPQG 323
P C+CP G
Sbjct: 1444 PVTGLCLCPPG 1454
Score = 35.0 bits (79), Expect = 0.16
Identities = 55/239 (23%), Positives = 81/239 (33%), Gaps = 37/239 (15%)
Query: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVD-IDECTIPPYCHQRC-VNTPGSFY---- 236
+C+ C ++ G AC+CPPG G C D + +C ++C G +
Sbjct: 569 SCQNGGTCDSVTG--ACRCPPGVS--GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYG 624
Query: 237 -CQCSPGFQLAANNYTCVD-------INECDASNQCAQQCYNILGSFICQCNQGYELSSD 288
C C PG + TC EC Q C GS C C G+
Sbjct: 625 ACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGS--CSCKAGFRGERC 682
Query: 289 RLNCE----DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQ----DINECE 339
+ CE + + C + G+ CP G+Q + C +N C
Sbjct: 683 QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVN-CS 741
Query: 340 TTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC------VCPVSNAMCRELPQS 392
++ C C G RC P +D PE R +CP R P++
Sbjct: 742 SSCSC-GGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPET 799
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 134 bits (336), Expect = 2e-31
Identities = 61/167 (36%), Positives = 93/167 (55%), Gaps = 8/167 (4%)
Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDEC--TIPPYCHQRCV 229
+D+DEC G +C AD +C N S+ C C PGYQ G QC DIDEC + C C+
Sbjct: 44 EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCL 103
Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASN-QCAQQCYNILGSFICQCNQGYELSSD 288
N PG++ C C GF LA + + C+D++EC +N C C N++GS+ C C +G+ LS +
Sbjct: 104 NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN 163
Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSR 330
+ C E+ C + C + C P G +C C G+++ +++
Sbjct: 164 QHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210
Score = 119 bits (297), Expect = 8e-27
Identities = 90/366 (24%), Positives = 144/366 (39%), Gaps = 46/366 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGM--KCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
C GY+ + +QC+DIDEC + GG C+N G Y C ++ ++
Sbjct: 73 CKPGYQGEG--RQCEDIDECG---NELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCL 127
Query: 87 ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
+ +G + G F++ + G + +
Sbjct: 128 DVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHI 187
Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
+ S +C G+E ++ N I C G C+ C + C C P Y+
Sbjct: 188 CKEAPRGSVACECRPGFELAK-NQRDCILTCNHGNGGCQ--HSCDDTADGPECSCHPQYK 244
Query: 207 KR--GEQCVDIDECTIPPY-----------------------------CHQRCVNTPGSF 235
G C++ ++ + C + C +T
Sbjct: 245 MHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGV 304
Query: 236 YCQCSPGFQLAANNYTCVDINECDASN-QCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
+C C GF L + TC DI+EC N C C NI+GSF C C +G++L +D +C+D
Sbjct: 305 HCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364
Query: 295 IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTN-ECREDEMCWNY 353
+DEC + C + C+N PG F+C C +GY + C D NEC N C+ ++C N
Sbjct: 365 VDEC-SLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQ--QVCVNT 421
Query: 354 HGGFRC 359
G + C
Sbjct: 422 VGSYEC 427
Score = 115 bits (289), Expect = 7e-26
Identities = 97/370 (26%), Positives = 138/370 (37%), Gaps = 45/370 (12%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
C DG+ C D+DEC C+ CVN G Y C K + +N Q T
Sbjct: 113 CFDGFMLAHDGHNCLDVDECLENNGGCQH--TCVNVMGSYECCCKEGFFLSDN----QHT 166
Query: 89 QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN------ 142
G + P G G E+ + + ++ N
Sbjct: 167 CIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRP--GFELAKNQRDCILTCNHGNGGC 224
Query: 143 ------PADPQRIPSNPSHRIQCAAG---------YEQSEHNVCQDIDEC---------- 177
AD +P +++ E +E N +D
Sbjct: 225 QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLME 284
Query: 178 TAGTHNCRADQVCINLRGSFACQCPPGY--QKRGEQCVDIDEC-TIPPYCHQRCVNTPGS 234
T +N D+ C + C CP G+ Q G+ C DIDEC T C C N GS
Sbjct: 285 TCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344
Query: 235 FYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
F C C GF+L + +C D++EC C C N G+F C CN+GY L +C D
Sbjct: 345 FDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYG-FTHCGD 403
Query: 295 IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINE-CETTNECREDEMCWN 352
+EC ++ CQ CVN G + C C GY++ + C ++ T+ R C
Sbjct: 404 TNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGK 463
Query: 353 YHGGFRCYPR 362
GG C+ R
Sbjct: 464 SGGGDGCFLR 473
Score = 99.4 bits (246), Expect = 7e-21
Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 21/206 (10%)
Query: 154 SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQ 211
S++ C GY Q E C+DIDEC N C+N+ G++ C C G+ G
Sbjct: 68 SYKCSCKPGY-QGEGRQCEDIDEC-GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHN 125
Query: 212 CVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE-----CDASNQCA 265
C+D+DEC C CVN GS+ C C GF L+ N +TC+ +E + + C+
Sbjct: 126 CLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCS 185
Query: 266 QQCYNI-LGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
C GS C+C G+EL+ ++ +C I C + CQ+ C + C C Y
Sbjct: 186 HICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQY 243
Query: 325 Q--------VVRSRTCQDINECETTN 342
+ + R T ++ E TT+
Sbjct: 244 KMHTDGRSCLEREDTVLEVTESNTTS 269
Score = 98.6 bits (244), Expect = 1e-20
Identities = 49/128 (38%), Positives = 67/128 (52%), Gaps = 7/128 (5%)
Query: 202 PPGYQKRGEQCVDIDECTIP-PYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINEC 258
PPG + D+DEC CH C NTP S+ C C PG+Q C DI+EC
Sbjct: 33 PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDEC 90
Query: 259 --DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKF 316
+ + C C NI G++ C C G+ L+ D NC D+DEC ++ CQ+ CVN G +
Sbjct: 91 GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY 150
Query: 317 SCMCPQGY 324
C C +G+
Sbjct: 151 ECCCKEGF 158
Score = 94.4 bits (233), Expect = 2e-19
Identities = 79/275 (28%), Positives = 114/275 (41%), Gaps = 55/275 (20%)
Query: 145 DPQRIPSNPSHRIQCAAGYEQSE--HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
D IP N +R C G+ + HN C D+DEC C+ C+N+ GS+ C C
Sbjct: 101 DCLNIPGN--YRCTCFDGFMLAHDGHN-CLDVDECLENNGGCQ--HTCVNVMGSYECCCK 155
Query: 203 PGYQKRGEQ--CVDIDE----CTIPPY-CHQRCVNTP-GSFYCQCSPGFQLAANNYTCVD 254
G+ Q C+ E C + C C P GS C+C PGF+LA N C
Sbjct: 156 EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213
Query: 255 INECDASN-QCAQQCYNILGSFICQCNQGYELSSDRLNC---ED---------------- 294
I C+ N C C + C C+ Y++ +D +C ED
Sbjct: 214 ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273
Query: 295 ---------IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTN-E 343
++ C ++ C C + C CP G+ + + +TC+DI+EC+T N
Sbjct: 274 DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333
Query: 344 CREDEMCWNYHGGFRCYPRNPCQDPY-ILTPENRC 377
C D C N G F C C+ + +LT E C
Sbjct: 334 C--DHFCKNIVGSFDC----GCKKGFKLLTDEKSC 362
Score = 84.7 bits (208), Expect = 2e-16
Identities = 52/138 (37%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 159 CAAGYEQ-SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG-EQCVDID 216
C G++ ++ CQD+DEC+ + D CIN G+FAC C GY G C D +
Sbjct: 349 CKKGFKLLTDEKSCQDVDECSL---DRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTN 405
Query: 217 ECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN---ECDASNQCAQQCYNIL 272
EC+I C Q CVNT GS+ CQC PG++L N CV++ S + + C
Sbjct: 406 ECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSG 465
Query: 273 GSFIC--QCNQGYELSSD 288
G C +C+ G LSSD
Sbjct: 466 GGDGCFLRCHSGIHLSSD 483
>gi|189491645 fibulin 7 isoform 1 [Homo sapiens]
Length = 439
Score = 134 bits (336), Expect = 2e-31
Identities = 100/366 (27%), Positives = 155/366 (42%), Gaps = 67/366 (18%)
Query: 153 PSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC 212
PS + G E C+ I EC++ C+ C+ + C CPPG + G +C
Sbjct: 116 PSSVVCLPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPG--RTGNRC 171
Query: 213 VDIDECTIPPYC---------HQRCVNTPGSFYCQCSPGFQL--AANNYTCVDINECDAS 261
+ P RC + +C C GF L AA + C D+NEC+
Sbjct: 172 QHQAQTAAPEGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELY 231
Query: 262 NQ------CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEP 313
Q C C N GS+ C C GY +D +CED+DEC +C C+N
Sbjct: 232 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 291
Query: 314 GKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNY--HGGFRCYPRNPCQDPYIL 371
G F C+ P EC E +Y F+C RNP
Sbjct: 292 GSFQCVSP---------------------ECPEGSGNVSYVKTSPFQC-ERNP------- 322
Query: 372 TPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA----NTINTFR 427
CP+ + CR LP++I + Y+S+ S+ P +F++ + N++ F
Sbjct: 323 -------CPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPGRAGPNSLR-FG 374
Query: 428 IKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTII 487
I GN G F ++++ + L+LV++L GP+ VD++M +F+ + V ++TI
Sbjct: 375 IVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLD-RSFQANHVSKVTIF 433
Query: 488 VGPFSF 493
V P+ F
Sbjct: 434 VSPYDF 439
Score = 35.4 bits (80), Expect = 0.12
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 29 CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
C GY + C+D+DEC + C G C+N G + C+
Sbjct: 255 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 297
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,548,018
Number of Sequences: 37866
Number of extensions: 1120259
Number of successful extensions: 8042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 2690
Number of HSP's gapped (non-prelim): 1942
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.