Guide to the Human Genome
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Search of human proteins with 86788015

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
         (493 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|86788132 EGF-containing fibulin-like extracellular matrix pro...  1048   0.0  
gi|86788015 EGF-containing fibulin-like extracellular matrix pro...  1048   0.0  
gi|9665262 EGF-containing fibulin-like extracellular matrix prot...  1048   0.0  
gi|190343004 EGF-containing fibulin-like extracellular matrix pr...   514   e-146
gi|19743803 fibulin 5 precursor [Homo sapiens]                        416   e-116
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              244   1e-64
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              243   3e-64
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              241   8e-64
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        209   6e-54
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              203   3e-52
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              203   3e-52
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      183   4e-46
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      182   8e-46
gi|118572606 hemicentin 1 [Homo sapiens]                              181   2e-45
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      179   4e-45
gi|4557733 latent transforming growth factor beta binding protei...   167   2e-41
gi|46249414 latent transforming growth factor beta binding prote...   167   3e-41
gi|46249412 latent transforming growth factor beta binding prote...   167   3e-41
gi|194328809 latent transforming growth factor beta binding prot...   166   4e-41
gi|18497288 latent transforming growth factor beta binding prote...   166   4e-41
gi|110347437 latent transforming growth factor beta binding prot...   158   9e-39
gi|110347412 latent transforming growth factor beta binding prot...   158   9e-39
gi|110347431 latent transforming growth factor beta binding prot...   158   9e-39
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]             144   1e-34
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]             144   1e-34
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    137   2e-32
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     135   1e-31
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               135   1e-31
gi|10190748 CEGP1 protein [Homo sapiens]                              134   2e-31
gi|189491645 fibulin 7 isoform 1 [Homo sapiens]                       134   2e-31

>gi|86788132 EGF-containing fibulin-like extracellular matrix
           protein 1 precursor [Homo sapiens]
          Length = 493

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
           MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60

Query: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
           CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120

Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
           SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180

Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
           THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240

Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
           PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300

Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
           SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360

Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
           PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420

Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
           NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480

Query: 481 VLRLTIIVGPFSF 493
           VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493


>gi|86788015 EGF-containing fibulin-like extracellular matrix
           protein 1 precursor [Homo sapiens]
          Length = 493

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
           MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60

Query: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
           CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120

Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
           SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180

Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
           THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240

Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
           PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300

Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
           SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360

Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
           PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420

Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
           NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480

Query: 481 VLRLTIIVGPFSF 493
           VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493


>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
           1 precursor [Homo sapiens]
          Length = 493

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60
           MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK
Sbjct: 1   MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 60

Query: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120
           CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA
Sbjct: 61  CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 120

Query: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180
           SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG
Sbjct: 121 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 180

Query: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240
           THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS
Sbjct: 181 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 240

Query: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300
           PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT
Sbjct: 241 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 300

Query: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360
           SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY
Sbjct: 301 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 360

Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
           PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA
Sbjct: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420

Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
           NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS
Sbjct: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480

Query: 481 VLRLTIIVGPFSF 493
           VLRLTIIVGPFSF
Sbjct: 481 VLRLTIIVGPFSF 493


>gi|190343004 EGF-containing fibulin-like extracellular matrix
           protein 2 [Homo sapiens]
          Length = 443

 Score =  514 bits (1325), Expect = e-146
 Identities = 241/488 (49%), Positives = 313/488 (64%), Gaps = 62/488 (12%)

Query: 7   LTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYG 66
           L +L L     QD+EE  +YT+CTDGYEWDP  Q C+D++EC  +P+ACKG MKC+NHYG
Sbjct: 17  LLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYG 76

Query: 67  GYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
           GYLC                                          LP    V +     
Sbjct: 77  GYLC------------------------------------------LPRSAAVINDLHGE 94

Query: 127 GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRA 186
           GP              P  P + P NP     C  GYE  + + C D+DEC    H+CR 
Sbjct: 95  GPPP------------PVPPAQHP-NP-----CPPGYEPDDQDSCVDVDECAQALHDCRP 136

Query: 187 DQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLA 246
            Q C NL GS+ C CP GY+K G +CVDIDEC    YC  RCVN PGSF CQC PGFQL 
Sbjct: 137 SQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRCVNLPGSFRCQCEPGFQLG 195

Query: 247 ANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ 306
            NN +CVD+NECD    C Q+C+N  G+F+C+C+QGYEL  D  +C DIDEC  SSYLCQ
Sbjct: 196 PNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQ 255

Query: 307 YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPC 365
           Y+CVNEPG+FSC CPQGYQ++ +R CQDI+ECE+  ++C E + C N+HGG+RC   N C
Sbjct: 256 YRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRC 315

Query: 366 QDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINT 425
            +PYI   ENRC+CP SN +CRE P SIV++YM+I S+RSVP+D+FQIQAT++Y    N 
Sbjct: 316 VEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVPADVFQIQATSVYPGAYNA 375

Query: 426 FRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLT 485
           F+I++GN  G+FY+RQ + VSAMLVL + ++GPRE+++DLEM+T++S+ ++R SSVLRLT
Sbjct: 376 FQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLT 435

Query: 486 IIVGPFSF 493
           + VG ++F
Sbjct: 436 VFVGAYTF 443


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  416 bits (1068), Expect = e-116
 Identities = 205/493 (41%), Positives = 278/493 (56%), Gaps = 52/493 (10%)

Query: 3   KALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCV 62
           + L +T+L L L    + +      QCT+G++ D    QC DIDEC  +P+AC+G M CV
Sbjct: 6   RILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV 60

Query: 63  NHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA 122
           N  GGYLC+P+T  +          T  +                        G + A+A
Sbjct: 61  NQNGGYLCIPRTNPVYRGPYSNPYSTPYS------------------------GPYPAAA 96

Query: 123 AAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTH 182
             ++ P   T                     S  + C  GY+  E N C D+DEC   +H
Sbjct: 97  PPLSAPNYPT--------------------ISRPLICRFGYQMDESNQCVDVDECATDSH 136

Query: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPG 242
            C   Q+CIN  G + C C  GY     QC+DIDEC    YC Q C N PGS+ C C+PG
Sbjct: 137 QCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSCTCNPG 195

Query: 243 FQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
           F L  +  +C D+NEC   N C Q C N  GSFIC+C+ GYEL  D ++C D+DEC  S 
Sbjct: 196 FTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSE 255

Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHGGFRCY 360
           +LCQ++CVN+PG + C CP GY ++  +R+CQDINECE  N  C   + C+N  GGF+C 
Sbjct: 256 FLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCI 315

Query: 361 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 420
               C++PY+   +NRC+CP  N  CR+ P +I+Y+ M + S RSVP+DIFQ+QATT Y 
Sbjct: 316 DPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP 375

Query: 421 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 480
                F+IKSGNE  EFY+RQT P+SA LV+ + + GPRE  +DLEM+TV+++  FR SS
Sbjct: 376 GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVINFRGSS 435

Query: 481 VLRLTIIVGPFSF 493
           V+RL I V  + F
Sbjct: 436 VIRLRIYVSQYPF 448


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  244 bits (623), Expect = 1e-64
 Identities = 152/472 (32%), Positives = 224/472 (47%), Gaps = 49/472 (10%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---LPKTAQIIVNNEQPQ 85
            C DGY  +  R+ C DI+EC      C  G  CVN  G + C   L       + + + +
Sbjct: 752  CADGYILNAHRK-CVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECE 810

Query: 86   QETQPAEGTSGATTGVVAASSMAT----------SGVL--PGGGFV-------ASAAAVA 126
               + A GT     G +  ++  +           G L  P G  V        S     
Sbjct: 811  DVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRP 870

Query: 127  GPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCR 185
            G        ++  +RNP             + CA GY  S+    C D++EC  G H C 
Sbjct: 871  GFSCINTVGSYTCQRNP-------------LICARGYHASDDGTKCVDVNECETGVHRCG 917

Query: 186  ADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSP 241
              QVC NL GS+ C C  G+Q+   G  C+D++EC   P   C   C NT GS+ C C+ 
Sbjct: 918  EGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCAS 977

Query: 242  GFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDEC-RT 300
            GF LAA+   C D+NEC+A  +C+Q+C NI GS+ C C QGY+L+ D   C DIDEC + 
Sbjct: 978  GFLLAADGKRCEDVNECEAQ-RCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQG 1036

Query: 301  SSYLCQYQCVNEPGKFSCMCP-QGY-QVVRSRTCQDINECET-TNECREDEMCWNYHGGF 357
            +  LC ++C+N PG + C CP QGY      R+C+D++EC   T+ C E E C N  G F
Sbjct: 1037 AGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSF 1096

Query: 358  RCYPRNPCQDPYILTPENRCVCPVSNAM--CRELPQSIVYKYMSIRSDRSVPSDIFQIQA 415
            RC  R  C   Y+   + +C     +    C+  P  I +  ++ ++   VP+ IF+I  
Sbjct: 1097 RCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQTGLLVPAHIFRIGP 1155

Query: 416  TTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEM 467
               +        I  GNE G F  R+ +  + ++ L +++  PR+  +D+EM
Sbjct: 1156 APAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQRAVLEPRDFALDVEM 1207



 Score =  150 bits (379), Expect = 3e-36
 Identities = 87/245 (35%), Positives = 117/245 (47%), Gaps = 27/245 (11%)

Query: 154 SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ----CPPGYQKRG 209
           +H + CA GY  + H  C DI+EC    H C   + C+N  GSF C     C PGY  + 
Sbjct: 747 NHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD 806

Query: 210 EQCVDIDECTIPPYCHQ---RCVNTPGSFYCQ----CSPGFQLAANNYTCVDINECDASN 262
            +C D+DEC +  +  Q    C NT GSFYCQ    C  GF L      CVDINEC + +
Sbjct: 807 GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLS 865

Query: 263 QCAQ---QCYNILGSFICQ-----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNE 312
           +  +    C N +GS+ CQ     C +GY  S D   C D++EC T  + C     C N 
Sbjct: 866 EPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNL 925

Query: 313 PGKFSCMCPQGYQ-VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
           PG + C C  G+Q     R C D+NEC  +        C N  G +RC     C   ++L
Sbjct: 926 PGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRC----SCASGFLL 981

Query: 372 TPENR 376
             + +
Sbjct: 982 AADGK 986



 Score =  130 bits (328), Expect = 2e-30
 Identities = 91/296 (30%), Positives = 130/296 (43%), Gaps = 30/296 (10%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C DG+  DP    C DI+EC  + + C+ G  C+N  G Y C  +   I         +
Sbjct: 842  RCMDGFLQDP-EGNCVDINECTSLSEPCRPGFSCINTVGSYTC-QRNPLICARGYHASDD 899

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                   +   TGV           LPG       A         GR    +    A P 
Sbjct: 900  GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAF--GRGCIDVNECWASPG 957

Query: 148  RIPSNP------SHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
            R+  +       S+R  CA+G+   ++   C+D++EC A     R  Q C N+ GS+ C 
Sbjct: 958  RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQCY 1013

Query: 201  CPPGYQ--KRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDI 255
            C  GYQ  + G  C DIDEC       C  RC+N PGS+ C C   G+ + AN  +C D+
Sbjct: 1014 CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1073

Query: 256  NECD-ASNQC--AQQCYNILGSFIC---QCNQGY----ELSSDRLNCEDIDECRTS 301
            +EC   ++ C  A+ C+NI GSF C   +C   Y    +   +R  C D  EC+ S
Sbjct: 1074 DECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1129



 Score =  112 bits (280), Expect = 8e-25
 Identities = 92/308 (29%), Positives = 123/308 (39%), Gaps = 64/308 (20%)

Query: 141 RNPADPQRIPSNPSH-----RIQCAAGYEQSEHNVC--QDIDECTAGTHNCRADQVCINL 193
           R P +P   P   S      R   + G E    N     D DEC           +CIN 
Sbjct: 565 RRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGEL-CQHLCINT 623

Query: 194 RGSFACQCPPGY--QKRGEQC---------------------VDIDECTIP--------- 221
            GS+ C C PG+  Q  G  C                       +   TIP         
Sbjct: 624 VGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTC 683

Query: 222 ---PYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQ--CYNILGSF 275
                C Q C    GS  C C PG+ + A+  +C D +EC   ++ C+++  C N LGSF
Sbjct: 684 KDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSF 743

Query: 276 ICQ-----CNQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEPGKFSCM----CPQGY 324
            C      C  GY L++ R  C DI+EC T  + C     CVN  G F C     C  GY
Sbjct: 744 YCVNHTVLCADGYILNAHR-KCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY 802

Query: 325 QVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV----C 379
             ++   C+D++EC   T+ C+   +C N  G F C  R  C D ++  PE  CV    C
Sbjct: 803 -ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINEC 861

Query: 380 PVSNAMCR 387
              +  CR
Sbjct: 862 TSLSEPCR 869


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  243 bits (620), Expect = 3e-64
 Identities = 139/438 (31%), Positives = 214/438 (48%), Gaps = 49/438 (11%)

Query: 41   QCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTG 100
            +C+D+DEC +    C+ G  C N  G + C  +   +    + P+          G    
Sbjct: 761  ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE----------GNCVD 810

Query: 101  VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA 160
            +   +S++     PG   + +  +            +  +RNP             + CA
Sbjct: 811  INECTSLSEP-CRPGFSCINTVGS------------YTCQRNP-------------LICA 844

Query: 161  AGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GEQCVDIDE 217
             GY  S+    C D++EC  G H C   QVC NL GS+ C C  G+Q+   G  C+D++E
Sbjct: 845  RGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNE 904

Query: 218  CTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSF 275
            C   P   C   C NT GS+ C C+ GF LAA+   C D+NEC+A  +C+Q+C NI GS+
Sbjct: 905  CWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIYGSY 963

Query: 276  ICQCNQGYELSSDRLNCEDIDEC-RTSSYLCQYQCVNEPGKFSCMCP-QGY-QVVRSRTC 332
             C C QGY+L+ D   C DIDEC + +  LC ++C+N PG + C CP QGY      R+C
Sbjct: 964  QCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSC 1023

Query: 333  QDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM--CREL 389
            +D++EC   T+ C E E C N  G FRC  R  C   Y+   + +C     +    C+  
Sbjct: 1024 KDVDECALGTHNCSEAETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNS 1082

Query: 390  PQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAML 449
            P  I +  ++ ++   VP+ IF+I     +        I  GNE G F  R+ +  + ++
Sbjct: 1083 PARITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVV 1142

Query: 450  VLVKSLSGPREHIVDLEM 467
             L +++  PR+  +D+EM
Sbjct: 1143 YLQRAVLEPRDFALDVEM 1160



 Score =  130 bits (328), Expect = 2e-30
 Identities = 91/296 (30%), Positives = 130/296 (43%), Gaps = 30/296 (10%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C DG+  DP    C DI+EC  + + C+ G  C+N  G Y C  +   I         +
Sbjct: 795  RCMDGFLQDP-EGNCVDINECTSLSEPCRPGFSCINTVGSYTC-QRNPLICARGYHASDD 852

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                   +   TGV           LPG       A         GR    +    A P 
Sbjct: 853  GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAF--GRGCIDVNECWASPG 910

Query: 148  RIPSNP------SHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
            R+  +       S+R  CA+G+   ++   C+D++EC A     R  Q C N+ GS+ C 
Sbjct: 911  RLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ----RCSQECANIYGSYQCY 966

Query: 201  CPPGYQ--KRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDI 255
            C  GYQ  + G  C DIDEC       C  RC+N PGS+ C C   G+ + AN  +C D+
Sbjct: 967  CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1026

Query: 256  NECD-ASNQC--AQQCYNILGSFIC---QCNQGY----ELSSDRLNCEDIDECRTS 301
            +EC   ++ C  A+ C+NI GSF C   +C   Y    +   +R  C D  EC+ S
Sbjct: 1027 DECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNS 1082



 Score =  118 bits (295), Expect = 1e-26
 Identities = 70/220 (31%), Positives = 94/220 (42%), Gaps = 47/220 (21%)

Query: 214 DIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTC------------------- 252
           D DEC + P   C   C+NT GS++C C PGF L  +  TC                   
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663

Query: 253 --------------VDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDEC 298
                            N C  +  C Q C  + GS IC C  GY + +D ++CEDI+EC
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINEC 723

Query: 299 RTSSYLCQ--YQCVNEPGKFSC----MCPQGYQVVRSRTCQDINECET-TNECREDEMCW 351
            T  + C     CVN  G F C     C  GY  ++   C+D++EC   T+ C+   +C 
Sbjct: 724 VTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY-ALKDGECEDVDECAMGTHTCQPGFLCQ 782

Query: 352 NYHGGFRCYPRNPCQDPYILTPENRCV----CPVSNAMCR 387
           N  G F C  R  C D ++  PE  CV    C   +  CR
Sbjct: 783 NTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCR 822


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  241 bits (616), Expect = 8e-64
 Identities = 158/498 (31%), Positives = 240/498 (48%), Gaps = 36/498 (7%)

Query: 18  QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
           +DT + +  + C  GY+       C+D++EC     +C+ G  C+N  G + C       
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 74  TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
           T   +  +   +   +   G        +  +++ +    P      GF+  A    G  
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306

Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
           +       +    P     I +  S+  Q     C  GY  +E    C D+DEC      
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366

Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
           C     C+N  GSF C+C  GY   G    CVD++EC   P   C  +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426

Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
           S GF+L+ +  +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485

Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
              T  ++C Y+C+N PG F C CP  GY++    R CQDI+EC T  + C  +E C+N 
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 354 HGGFRCYPRNPCQDPYILTPENRCV---CPVSNAMCRELPQSIVYKYMSIRSDRSVPSDI 410
            GGFRC     C + Y  +   RC    C   N  C +LP  I Y ++S  ++   P+ +
Sbjct: 546 QGGFRCLAFE-CPENYRRSAATRCERLPCH-ENRECSKLPLRITYYHLSFPTNIQAPAVV 603

Query: 411 FQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTV 470
           F++  ++          I  GNE G F  R+ SP S ++ L K +  PR+ ++ ++M  +
Sbjct: 604 FRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKM-DL 662

Query: 471 SSIGTFRTSSVLRLTIIV 488
           S  GT  +S V +L I V
Sbjct: 663 SRHGTV-SSFVAKLFIFV 679



 Score =  100 bits (248), Expect = 4e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  209 bits (531), Expect = 6e-54
 Identities = 159/521 (30%), Positives = 240/521 (46%), Gaps = 53/521 (10%)

Query: 18  QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
           +DT + +  + C  GY+       C+D++EC     +C+ G  C+N  G + C       
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 74  TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
           T   +  +   +   +   G        +  +++ +    P      GF+  A    G  
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306

Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
           +       +    P     I +  S+  Q     C  GY  +E    C D+DEC      
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366

Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
           C     C+N  GSF C+C  GY   G    CVD++EC   P   C  +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426

Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
           S GF+L+ +  +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485

Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
              T  ++C Y+C+N PG F C CP  GY++    R CQDI+EC T  + C  +E C+N 
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 354 HGGFRCY----PRNPCQDPYILTPEN----RCV--CPVSNAMCRELP-QSIVYKYMSIRS 402
            GGFRC     P N  +    L  E     RC+  C  ++  C   P  +I +  +S+ +
Sbjct: 546 QGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPT 605

Query: 403 DRSV--PSDIFQIQATT-----IYANTINTFRIKSGNENGEFYL--RQTSPVSAMLV-LV 452
            R    P +I  ++A T       AN I  F I  GN    F +  R    ++  +V  V
Sbjct: 606 FREFTRPEEIIFLRAITPPHPASQANII--FDITEGNLRDSFDIIKRYMDGMTVGVVRQV 663

Query: 453 KSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF 493
           + + GP   ++ LEM  V   G     +V+ + I V  + F
Sbjct: 664 RPIVGPFHAVLKLEMNYVVG-GVVSHRNVVNVHIFVSEYWF 703



 Score =  100 bits (248), Expect = 4e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  203 bits (516), Expect = 3e-52
 Identities = 121/366 (33%), Positives = 178/366 (48%), Gaps = 29/366 (7%)

Query: 18  QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
           +DT + +  + C  GY+       C+D++EC     +C+ G  C+N  G + C       
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 74  TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
           T   +  +   +   +   G        +  +++ +    P      GF+  A    G  
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306

Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
           +       +    P     I +  S+  Q     C  GY  +E    C D+DEC      
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366

Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
           C     C+N  GSF C+C  GY   G    CVD++EC   P   C  +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426

Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
           S GF+L+ +  +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485

Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
              T  ++C Y+C+N PG F C CP  GY++    R CQDI+EC T  + C  +E C+N 
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 354 HGGFRC 359
            GGFRC
Sbjct: 546 QGGFRC 551



 Score =  100 bits (248), Expect = 4e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 52/205 (25%), Positives = 78/205 (38%), Gaps = 50/205 (24%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
           +C  GY +D + + C D++EC   P    G  KC N  G YLC      ++ V+    + 
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 87  ETQPAEGTSGATTGVVAASSMA----------TSGV---------LPGGGFVASAAAVAG 127
             + +          V  S               GV         LP GG + S   +  
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI-- 499

Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCR 185
                                IP   S +  C ++GY  + +   CQDIDEC  G HNC 
Sbjct: 500 --------------------NIPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCS 537

Query: 186 ADQVCINLRGSFAC---QCPPGYQK 207
            ++ C N++G F C   +CP  Y++
Sbjct: 538 INETCFNIQGGFRCLAFECPENYRR 562


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  203 bits (516), Expect = 3e-52
 Identities = 121/366 (33%), Positives = 178/366 (48%), Gaps = 29/366 (7%)

Query: 18  QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK---- 73
           +DT + +  + C  GY+       C+D++EC     +C+ G  C+N  G + C       
Sbjct: 191 RDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCG 249

Query: 74  TAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPG----GGFVASAAAVAGPE 129
           T   +  +   +   +   G        +  +++ +    P      GF+  A    G  
Sbjct: 250 TGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDAL---GNC 306

Query: 130 MQTGRNNFVIRRNPADPQRIPSNPSHRIQ-----CAAGYEQSEHNV-CQDIDECTAGTHN 183
           +       +    P     I +  S+  Q     C  GY  +E    C D+DEC      
Sbjct: 307 IDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEP 366

Query: 184 CRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDECTIPP--YCHQRCVNTPGSFYCQC 239
           C     C+N  GSF C+C  GY   G    CVD++EC   P   C  +C NT GS+ C C
Sbjct: 367 CGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSC 426

Query: 240 SPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSS-DRLNCEDIDEC 298
           S GF+L+ +  +C DINEC +S+ C+Q+C N+ GS+ C C +GY+LS  D + CEDIDEC
Sbjct: 427 SVGFRLSVDGRSCEDINEC-SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDEC 485

Query: 299 R--TSSYLCQYQCVNEPGKFSCMCPQ-GYQVV-RSRTCQDINECET-TNECREDEMCWNY 353
              T  ++C Y+C+N PG F C CP  GY++    R CQDI+EC T  + C  +E C+N 
Sbjct: 486 ALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNI 545

Query: 354 HGGFRC 359
            GGFRC
Sbjct: 546 QGGFRC 551



 Score =  100 bits (248), Expect = 4e-21
 Identities = 64/179 (35%), Positives = 83/179 (46%), Gaps = 17/179 (9%)

Query: 216 DECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQC--AQQCYNIL 272
           D C     C Q+C +T     C C  G+QL ++  +C D+NEC   S+ C   + C N +
Sbjct: 178 DRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTV 237

Query: 273 GSFICQ----CNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSC----MCPQ 322
           GSF CQ    C  GYEL+ D  +C+DIDEC +  + C   + C N  G F C     C  
Sbjct: 238 GSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKS 296

Query: 323 GYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNP-CQDPYILTPE-NRCV 378
           G+       C DINEC   +  C     C N  G + C    P C   Y L  E  RCV
Sbjct: 297 GFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCV 355



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 52/205 (25%), Positives = 78/205 (38%), Gaps = 50/205 (24%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
           +C  GY +D + + C D++EC   P    G  KC N  G YLC      ++ V+    + 
Sbjct: 383 ECKTGYYFDGISRMCVDVNECQRYPGRLCGH-KCENTLGSYLCSCSVGFRLSVDGRSCED 441

Query: 87  ETQPAEGTSGATTGVVAASSMA----------TSGV---------LPGGGFVASAAAVAG 127
             + +          V  S               GV         LP GG + S   +  
Sbjct: 442 INECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCI-- 499

Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQC-AAGYEQSEHNV-CQDIDECTAGTHNCR 185
                                IP   S +  C ++GY  + +   CQDIDEC  G HNC 
Sbjct: 500 --------------------NIPG--SFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCS 537

Query: 186 ADQVCINLRGSFAC---QCPPGYQK 207
            ++ C N++G F C   +CP  Y++
Sbjct: 538 INETCFNIQGGFRCLAFECPENYRR 562


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  183 bits (464), Expect = 4e-46
 Identities = 108/339 (31%), Positives = 160/339 (47%), Gaps = 17/339 (5%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY+  P RQ C DIDEC I+   C    +C N  G Y C       ++ + +   + 
Sbjct: 1227 CNPGYQATPDRQGCTDIDECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDGRSCADI 1284

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-QTGRNNFVIRRNPADPQ 147
               E       G    +       L   GF+AS       ++ +   N+ +      +  
Sbjct: 1285 DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENT 1344

Query: 148  RIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
            +     S    C  GY   +    C D+DEC  G HNC     C+N+ GSF C C  G+ 
Sbjct: 1345 K----GSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400

Query: 207  KRGEQCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASN 262
              G +C+D+DEC+   +    + +CVNTPGS+ C CS GF    + +TC D++EC +  N
Sbjct: 1401 GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENIN 1458

Query: 263  QCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
             C   QC N+ G++ C+C  G+  +SD  +C+DIDEC   +      C N PG F C+C 
Sbjct: 1459 LCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICD 1518

Query: 322  QGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
             GY++ R+   C DI+EC     C  + +C N  G + C
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINC-VNGLCVNTPGRYEC 1556



 Score =  175 bits (444), Expect = 7e-44
 Identities = 104/342 (30%), Positives = 147/342 (42%), Gaps = 61/342 (17%)

Query: 43   KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVV 102
            +DIDEC ++P+ C  G +C+N  G + C  K              T    GTS       
Sbjct: 2448 RDIDECKVMPNLCTNG-QCINTMGSFRCFCKVGY-----------TTDISGTSCIDLDEC 2495

Query: 103  AASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAG 162
            + S                              N++ +             S++  C  G
Sbjct: 2496 SQSPKPC--------------------------NYICKNTEG---------SYQCSCPRG 2520

Query: 163  YE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDEC-TI 220
            Y  Q +   C+D+DEC    HNC+   +C+N  G F C+CPPG+ +    C+D +EC + 
Sbjct: 2521 YVLQEDGKTCKDLDECQTKQHNCQF--LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQ 2578

Query: 221  PPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQ 278
            P  C  +  C NTPGSF C+C  GF L A    C D++ECD +++C   C NILG + C 
Sbjct: 2579 PSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCG 2638

Query: 279  CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINE 337
            C QGY        C D +EC   +      C N  G + C CP G+   + S  C D+NE
Sbjct: 2639 CPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNE 2698

Query: 338  CETT-NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
            C ++ N C     C N  GG+ C     C   Y    +  CV
Sbjct: 2699 CSSSKNPCNYG--CSNTEGGYLC----GCPPGYYRVGQGHCV 2734



 Score =  172 bits (436), Expect = 6e-43
 Identities = 113/390 (28%), Positives = 174/390 (44%), Gaps = 51/390 (13%)

Query: 42   CKDIDECDIVPDACKGGMKCVNHYGGY-------LCLPKTAQIIVNNEQPQQETQ----- 89
            C+D++EC++ P  C  G +CVN  G +       L L  T ++ ++    Q   +     
Sbjct: 953  CEDVNECEVFPGVCPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDE 1011

Query: 90   -----PAEGTSGATTGVVAASSMATSGVLP-------------GGGFVASAAAVAGPEMQ 131
                 P +    A    V A+        P             G GF      + G    
Sbjct: 1012 CIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFY 1071

Query: 132  TGRNNFVIRRNPADPQRIPSN-PSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQV 189
               N            +  +   S + +C +G+    E   C DIDEC      C +  +
Sbjct: 1072 KDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSG-I 1130

Query: 190  CINLRGSFACQCPPGYQK---RGEQCVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQ 244
            C+N  GSF C+C  GY+      + C+DIDEC   P   +   CVNT GSF C C  G +
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190

Query: 245  LAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
            L+ +   CVDINEC  S+   +  +C N++G++ C CN GY+ + DR  C DIDEC   +
Sbjct: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250

Query: 303  YLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGFRCYP 361
              C  QC N  G + C C +GY ++   R+C DI+ECE   +  +   C N  G +RC  
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCL- 1309

Query: 362  RNPCQDPYILTPENR-CV----CPVSNAMC 386
               C D ++ + + + C+    C +++ +C
Sbjct: 1310 ---CYDGFMASMDMKTCIDVNECDLNSNIC 1336



 Score =  172 bits (436), Expect = 6e-43
 Identities = 112/361 (31%), Positives = 164/361 (45%), Gaps = 58/361 (16%)

Query: 32   GYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPA 91
            G+ +D    +  DIDEC  +P  C  G+ C+N  G + C   T                 
Sbjct: 1796 GFTFDIHTGKAVDIDECKEIPGICANGV-CINQIGSFRCECPT----------------- 1837

Query: 92   EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPS 151
                                     GF  +   +   ++    N   + +  AD    P 
Sbjct: 1838 -------------------------GFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872

Query: 152  NPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ 211
              S+R +CAAG++ S +  C D +EC    + C +  +C++L+GS+ C C  G++   +Q
Sbjct: 1873 --SYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQ 1929

Query: 212  --CVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA--SNQCAQ- 266
              C+D+DEC   P  +  C NT GS+ C C PGF+L  NN  C+DI+EC +     C   
Sbjct: 1930 TMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNN-DCLDIDECSSFFGQVCRNG 1988

Query: 267  QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQ 325
            +C+N +GSF C CN+GYEL+ D  NC D +EC      C    C N  G F C+CP GY+
Sbjct: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE 2048

Query: 326  VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM 385
             V+S  C DINEC+          C N  GGF+C     C   ++L+   R       + 
Sbjct: 2049 -VKSENCIDINECDEDPNICLFGSCTNTPGGFQCL----CPPGFVLSDNGRRCFDTRQSF 2103

Query: 386  C 386
            C
Sbjct: 2104 C 2104



 Score =  169 bits (427), Expect = 7e-42
 Identities = 111/353 (31%), Positives = 154/353 (43%), Gaps = 38/353 (10%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLP----KTAQIIVNNEQ 83
            +C  G+  D   + C DIDEC I PD C  G+ CVN  G + C      ++  +++ N  
Sbjct: 1099 RCNSGFALDMEERNCTDIDECRISPDLCGSGI-CVNTPGSFECECFEGYESGFMMMKNCM 1157

Query: 84   PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
               E +         T V    S      L             G E+   R + V     
Sbjct: 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPL-------------GHELSPSREDCVDINEC 1204

Query: 144  ADPQRIPSNP-------SHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRG 195
            +    +  N        +++  C  GY+ + +   C DIDEC      C  D  C N  G
Sbjct: 1205 SLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC--DTQCTNSEG 1262

Query: 196  SFACQCPPGY--QKRGEQCVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYT 251
            S+ C C  GY     G  C DIDEC   P  C   +C N PG + C C  GF  + +  T
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKT 1322

Query: 252  CVDINECDA-SNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-- 307
            C+D+NECD  SN C   +C N  GSFIC C  GY +      C D+DEC   ++ C    
Sbjct: 1323 CIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHA 1382

Query: 308  QCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRC 359
             C+N PG F C C +G+ +     C D++EC   T++C  +  C N  G +RC
Sbjct: 1383 SCLNIPGSFKCSCREGW-IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRC 1434



 Score =  163 bits (413), Expect = 3e-40
 Identities = 118/388 (30%), Positives = 162/388 (41%), Gaps = 63/388 (16%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACK-----------------------GGMKCVNH 64
           +C  G++     Q+C+DIDEC I+P  C+                        G +C++ 
Sbjct: 302 RCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQ 361

Query: 65  YGGYLCLPKTAQIIVNNEQPQQET------QPAE----GTSGATTGVVAASS---MATSG 111
             G +C           E P + T      +P      GT      V  +     +   G
Sbjct: 362 RTG-MCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG 420

Query: 112 VLPGGGFVASAAAVAGPEMQTGRNNFVIRRN-----PADPQRIPSNPSHRIQCAAGYEQS 166
            LP GG   SA +  G    TG N F    N     P     IP    +      G    
Sbjct: 421 -LPMGGIPGSAGSRPGG---TGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGV 476

Query: 167 EHN-----------VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY-QKRGEQCVD 214
                         + Q ID C    + C   + CI    S+ C+C  GY Q     C+D
Sbjct: 477 GAGGQGPIITGLTILNQTIDICKHHANLCLNGR-CIPTVSSYRCECNMGYKQDANGDCID 535

Query: 215 IDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNIL 272
           +DECT  P  +  CVNTPGS+YC+C  GFQ       C+DI+EC  +    +  +C N  
Sbjct: 536 VDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD 595

Query: 273 GSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRT 331
           GSF C CN G+EL++D  NC D DEC T++      C+NE G F C+C  G+ +    R 
Sbjct: 596 GSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRY 655

Query: 332 CQDINECETTNECREDEMCWNYHGGFRC 359
           C D++EC+T   C     C N  G FRC
Sbjct: 656 CTDVDECQTPGICMNGH-CINSEGSFRC 682



 Score =  162 bits (411), Expect = 5e-40
 Identities = 105/311 (33%), Positives = 141/311 (45%), Gaps = 27/311 (8%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------PKTAQII 78
            C++GY   P  + C DIDEC+  PD C GG +C N  G Y CL           KT   I
Sbjct: 1268 CSEGYALMPDGRSCADIDECENNPDICDGG-QCTNIPGEYRCLCYDGFMASMDMKTC--I 1324

Query: 79   VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
              NE          G    T G           V  G     +       E + G +N  
Sbjct: 1325 DVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKG-----TTGCTDVDECEIGAHNCD 1379

Query: 139  IRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFA 198
            +    A    IP   S +  C  G+  +    C D+DEC+ GTH C  +  C+N  GS+ 
Sbjct: 1380 MH---ASCLNIPG--SFKCSCREGWIGNGIK-CIDLDECSNGTHQCSINAQCVNTPGSYR 1433

Query: 199  CQCPPGYQKRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
            C C  G+   G  C D+DEC   I    + +C+N PG++ C+C  GF  A+++ +C DI+
Sbjct: 1434 CACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDID 1493

Query: 257  ECDASNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
            EC   N C    C N+ G F C C+ GYEL     NC DIDEC          CVN PG+
Sbjct: 1494 ECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGR 1553

Query: 316  FSCMCPQGYQV 326
            + C CP  +Q+
Sbjct: 1554 YECNCPPDFQL 1564



 Score =  159 bits (403), Expect = 4e-39
 Identities = 86/217 (39%), Positives = 117/217 (53%), Gaps = 12/217 (5%)

Query: 154  SHRIQCAAGYEQSEHNV--CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
            S   +C  GYE     +  C DIDEC      CR    C+N  GSF C CP G++     
Sbjct: 1137 SFECECFEGYESGFMMMKNCMDIDECERNPLLCRGG-TCVNTEGSFQCDCPLGHELSPSR 1195

Query: 210  EQCVDIDECTIPP-YCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQ 266
            E CVDI+EC++    C   +CVN  G++ C C+PG+Q   +   C DI+EC   N  C  
Sbjct: 1196 EDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDT 1255

Query: 267  QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQ 325
            QC N  GS+ C C++GY L  D  +C DIDEC  +  +C   QC N PG++ C+C  G+ 
Sbjct: 1256 QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFM 1315

Query: 326  V-VRSRTCQDINECE-TTNECREDEMCWNYHGGFRCY 360
              +  +TC D+NEC+  +N C   E C N  G F C+
Sbjct: 1316 ASMDMKTCIDVNECDLNSNICMFGE-CENTKGSFICH 1351



 Score =  154 bits (390), Expect = 1e-37
 Identities = 115/365 (31%), Positives = 163/365 (44%), Gaps = 44/365 (12%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVN---NEQP 84
            +C  GY      + C+DIDEC   P  C  G  C N  G Y C+     + VN   N   
Sbjct: 1676 ECPQGYYLSEDTRICEDIDECFAHPGVCGPG-TCYNTLGNYTCICPPEYMQVNGGHNCMD 1734

Query: 85   QQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPA 144
             +++      +G T              LP    V          +    N       P 
Sbjct: 1735 MRKSFCYRSYNGTT----------CENELPFN--VTKRMCCCTYNVGKAWN------KPC 1776

Query: 145  DPQRIPSNPSHRIQCA--AGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
            +P   P     +  C    G+    H     DIDEC      C A+ VCIN  GSF C+C
Sbjct: 1777 EPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC-ANGVCINQIGSFRCEC 1835

Query: 202  PPG--YQKRGEQCVDIDECTIPPYCHQR---CVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
            P G  Y      C DIDEC+      QR   C+N+PGS+ C+C+ GF+L+ N   CVD N
Sbjct: 1836 PTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRN 1894

Query: 257  EC-DASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEP 313
            EC +  N C+   C ++ GS+ C C+ G++ S D+  C D+DEC    + C    C N  
Sbjct: 1895 ECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTV 1952

Query: 314  GKFSCMCPQGYQVVRSRTCQDINECET--TNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
            G ++C+C  G+++  +  C DI+EC +     CR    C+N  G F+C     C + Y L
Sbjct: 1953 GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGR-CFNEIGSFKCL----CNEGYEL 2007

Query: 372  TPENR 376
            TP+ +
Sbjct: 2008 TPDGK 2012



 Score =  153 bits (387), Expect = 3e-37
 Identities = 113/352 (32%), Positives = 151/352 (42%), Gaps = 52/352 (14%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GYE     + C DI+ECD  P+ C  G  C N  GG+ CL     ++ +N +   +T
Sbjct: 2043 CPPGYEVKS--ENCIDINECDEDPNICLFG-SCTNTPGGFQCLCPPGFVLSDNGRRCFDT 2099

Query: 89   QPA-------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRR 141
            + +        G            +      +PG G+                       
Sbjct: 2100 RQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGW----------------------- 2136

Query: 142  NPADPQRI-PSNPSHRIQ--CAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
               DP  + P +     Q  C  G+    S H+  +D++EC      C   Q CIN  GS
Sbjct: 2137 --GDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ-CINTDGS 2193

Query: 197  FACQCPPGYQK--RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            F C+CP GY     G +CVD DEC+I   C +  C N  GSF C C+ GF+       C 
Sbjct: 2194 FRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNCE 2252

Query: 254  DINECDASNQ--CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ---YQ 308
            DINEC A N   CA +C N  GS+ C C  GY L  D+  C+D+DEC    + C+     
Sbjct: 2253 DINEC-AQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311

Query: 309  CVNEPGKFSCMCPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            C N  G F C+CP G  +      C D NEC T     E+  C N  G +RC
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRC 2363



 Score =  148 bits (373), Expect = 1e-35
 Identities = 85/242 (35%), Positives = 118/242 (48%), Gaps = 9/242 (3%)

Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
           IP+  S+R +C  GY+Q  +  C D+DECT+   N   +  C+N  GS+ C+C  G+Q+ 
Sbjct: 511 IPTVSSYRCECNMGYKQDANGDCIDVDECTS---NPCTNGDCVNTPGSYYCKCHAGFQRT 567

Query: 209 G--EQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
              + C+DIDEC        + RCVNT GSF C C+ GF+L  +   CVD +EC  +N C
Sbjct: 568 PTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMC 627

Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
               C N  GSF C C  G+ L+ +   C D+DEC+T        C+N  G F C CP G
Sbjct: 628 LNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPG 687

Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVS 382
             V +  R C D +   T     +  +C     G        C +P     E    CP  
Sbjct: 688 LAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747

Query: 383 NA 384
           N+
Sbjct: 748 NS 749



 Score =  141 bits (356), Expect = 1e-33
 Identities = 109/370 (29%), Positives = 146/370 (39%), Gaps = 71/370 (19%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  G+   P  + C D+DEC   P  C  G  C+N  G + C                + 
Sbjct: 643 CKPGFVLAPNGRYCTDVDECQ-TPGICMNG-HCINSEGSFRC----------------DC 684

Query: 89  QP--AEGTSGATTGVVAASSMATSGVLPG-------GGFVASAAAVAGPEMQTGRNNFVI 139
            P  A G  G         S    G+  G       G    S    A P+   G      
Sbjct: 685 PPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGE----- 739

Query: 140 RRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
              P  P    ++      C++G   +     +DI+EC      C A+ +C NLRGS+ C
Sbjct: 740 ---PCQPCPAKNSAEFHGLCSSGVGITVDG--RDINECALDPDIC-ANGICENLRGSYRC 793

Query: 200 QCPPGYQK--RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDI 255
            C  GY+    G  C+DIDEC +         C NTPGS+ C C PG+       TC DI
Sbjct: 794 NCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853

Query: 256 NECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYL------CQYQ 308
           NEC+ SN C    C N LGSF C+C+ G +LSS  L C  ID  + + +L      C+  
Sbjct: 854 NECE-SNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC--IDSLKGTCWLNIQDSRCEVN 910

Query: 309 CVNEPGKFSC-------------------MCPQGYQVVRSRTCQDINECETTNECREDEM 349
                 K  C                    CP+G   ++  TC+D+NECE       +  
Sbjct: 911 INGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGR 970

Query: 350 CWNYHGGFRC 359
           C N  G F C
Sbjct: 971 CVNSKGSFHC 980



 Score =  136 bits (343), Expect = 4e-32
 Identities = 99/348 (28%), Positives = 145/348 (41%), Gaps = 46/348 (13%)

Query: 29   CTDGYEWDPVRQQCKDIDEC-DIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIV 79
            C  GY     ++ CKD+DEC + + D    GM C N  G ++C+        P     + 
Sbjct: 2279 CPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVD 2338

Query: 80   NNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVI 139
             NE     T+P    +G    ++ +     +      GF +S++   G E    R     
Sbjct: 2339 ENEC---RTKPGICENGRCVNIIGSYRCECNE-----GFQSSSS---GTECLDNRQGLCF 2387

Query: 140  RRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGT----HNCRADQVCINLRG 195
                          +  +Q       S  N+    + C  G     H C    +    + 
Sbjct: 2388 --------------AEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQY 2433

Query: 196  SFACQCPPGYQKRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
               C   PGY   G    DIDEC + P    + +C+NT GSF C C  G+    +  +C+
Sbjct: 2434 KKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCI 2490

Query: 254  DINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE 312
            D++EC  S + C   C N  GS+ C C +GY L  D   C+D+DEC+T  + CQ+ CVN 
Sbjct: 2491 DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT 2550

Query: 313  PGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
             G F+C CP G+       C D NEC    + C    +C N  G F C
Sbjct: 2551 LGGFTCKCPPGF-TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSC 2597



 Score =  133 bits (335), Expect = 3e-31
 Identities = 109/379 (28%), Positives = 147/379 (38%), Gaps = 61/379 (16%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY        C D+DEC+I    C     C+N  G + C  +    I N  +     
Sbjct: 1352 CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW-IGNGIKCIDLD 1410

Query: 89   QPAEGTSGATTGVVAASS-----MATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
            + + GT   +      ++      A S    G GF  S        +    N   +    
Sbjct: 1411 ECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCL---- 1466

Query: 144  ADPQRIPSNPSHRIQCAAGY-EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
                 +P   ++R +C  G+   S+   CQDIDEC+    N      C NL G F C C 
Sbjct: 1467 ----NVPG--AYRCECEMGFTPASDSRSCQDIDECS--FQNICVFGTCNNLPGMFHCICD 1518

Query: 203  PGYQ--KRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVD--INE 257
             GY+  + G  C DIDEC  P  C +  CVNTPG + C C P FQL      CVD  +  
Sbjct: 1519 DGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGN 1578

Query: 258  C--------DASNQC---------AQQCYNILGS------------------FICQCNQG 282
            C        D S  C            C   LG                    +C   +G
Sbjct: 1579 CYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEG 1638

Query: 283  YELSSDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECET 340
            +  +   +  EDIDEC+    LCQ   C+N  G F C CPQGY +   +R C+DI+EC  
Sbjct: 1639 FRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFA 1698

Query: 341  TNECREDEMCWNYHGGFRC 359
                     C+N  G + C
Sbjct: 1699 HPGVCGPGTCYNTLGNYTC 1717



 Score =  132 bits (333), Expect = 5e-31
 Identities = 116/429 (27%), Positives = 171/429 (39%), Gaps = 81/429 (18%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GYE D   + C DIDEC +    C  G+ C N  G Y C      +     +  ++ 
Sbjct: 795  CNSGYEPDASGRNCIDIDECLVNRLLCDNGL-CRNTPGSYSCTCPPGYVFRTETETCEDI 853

Query: 89   QPAEGT---SGATTGVVAA--------SSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
               E     +GA    + +        S ++++G++     + S        +Q  R   
Sbjct: 854  NECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLI----CIDSLKGTCWLNIQDSRCEV 909

Query: 138  VIRRNPADPQRIPS------NPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRAD 187
             I       +   +      +P  R +    C  G  + +   C+D++EC      C   
Sbjct: 910  NINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNG 969

Query: 188  QVCINLRGSFACQCPPGY--QKRGEQCVDI--DECTIPPYCHQRCVN-TPGSFY---CQC 239
            + C+N +GSF C+CP G      G  C+DI  ++C +  +    C++  PG F    C C
Sbjct: 970  R-CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLK-WDEDECIHPVPGKFRMDACCC 1027

Query: 240  SPGFQLAANNYTCV-------------------------------DINECDA-SNQCAQ- 266
            + G         C                                DINEC A    C   
Sbjct: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087

Query: 267  QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQ 325
            +C N +GSF C+CN G+ L  +  NC DIDECR S  LC    CVN PG F C C +GY+
Sbjct: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147

Query: 326  --VVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV---- 378
               +  + C DI+ECE          C N  G F+C     C   + L+P    CV    
Sbjct: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQC----DCPLGHELSPSREDCVDINE 1203

Query: 379  CPVSNAMCR 387
            C +S+ +CR
Sbjct: 1204 CSLSDNLCR 1212



 Score =  129 bits (323), Expect = 8e-30
 Identities = 126/441 (28%), Positives = 173/441 (39%), Gaps = 90/441 (20%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVNN 81
            C DGYE D     C DIDEC   P  C  G+ CVN  G Y C       L  T    V+N
Sbjct: 1517 CDDGYELDRTGGNCTDIDEC-ADPINCVNGL-CVNTPGRYECNCPPDFQLNPTGVGCVDN 1574

Query: 82   EQPQQETQ---PAEGTSGATTGV---VAASSMATSGVLPGGGFVASAAAVAGPEMQT--- 132
                   +     +G+    T +   V+ SS   S     G    +   V   E  T   
Sbjct: 1575 RVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCP 1634

Query: 133  GRNNF------VIRRNPADPQRIP----------SNPSHRIQCAAGYEQSEHN-VCQDID 175
            G   F      +I  +  + Q +P          +  S + +C  GY  SE   +C+DID
Sbjct: 1635 GGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694

Query: 176  ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQR-----C 228
            EC A    C     C N  G++ C CPP Y +   G  C+D+ +     +C++      C
Sbjct: 1695 ECFAHPGVC-GPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKS----FCYRSYNGTTC 1749

Query: 229  VN-----------------------------TPGSF----YCQCSPGFQLAANNYTCVDI 255
             N                             TPG+      C   PGF    +    VDI
Sbjct: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDI 1809

Query: 256  NEC-DASNQCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ--YQCVN 311
            +EC +    CA   C N +GSF C+C  G+  +   L CEDIDEC     LCQ    C+N
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCIN 1869

Query: 312  EPGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRN---PCQD 367
             PG + C C  G+++  +  C D NEC E  N C    +C +  G ++C   N     QD
Sbjct: 1870 SPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG-LCVDLQGSYQCICHNGFKASQD 1928

Query: 368  PYILTPENRCV-CPVSNAMCR 387
              +    + C   P  N  C+
Sbjct: 1929 QTMCMDVDECERHPCGNGTCK 1949



 Score =  127 bits (318), Expect = 3e-29
 Identities = 106/373 (28%), Positives = 140/373 (37%), Gaps = 93/373 (24%)

Query: 26  YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
           Y +C  G++  P +Q C DIDEC      CK G +CVN  G + C+      +       
Sbjct: 557 YCKCHAGFQRTPTKQACIDIDECIQNGVLCKNG-RCVNTDGSFQCICNAGFELT------ 609

Query: 86  QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
                 +G +         ++M  +G+                                 
Sbjct: 610 -----TDGKNCVDHDECTTTNMCLNGMC-------------------------------- 632

Query: 146 PQRIPSNPSHRIQCAAGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
              I  + S +  C  G+  + +   C D+DEC   T     +  CIN  GSF C CPPG
Sbjct: 633 ---INEDGSFKCICKPGFVLAPNGRYCTDVDECQ--TPGICMNGHCINSEGSFRCDCPPG 687

Query: 205 YQ--KRGEQCVDIDE---------------------------CTIPPY-----CHQRCVN 230
                 G  CVD                              C  P Y     C      
Sbjct: 688 LAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747

Query: 231 TPGSFYCQCSPGFQLAANNYTCVDINECDAS-NQCAQQ-CYNILGSFICQCNQGYELSSD 288
               F+  CS G  +  +     DINEC    + CA   C N+ GS+ C CN GYE  + 
Sbjct: 748 NSAEFHGLCSSGVGITVDGR---DINECALDPDICANGICENLRGSYRCNCNSGYEPDAS 804

Query: 289 RLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECRE 346
             NC DIDEC  +  LC    C N PG +SC CP GY     + TC+DINECE +N C  
Sbjct: 805 GRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECE-SNPC-V 862

Query: 347 DEMCWNYHGGFRC 359
           +  C N  G F C
Sbjct: 863 NGACRNNLGSFNC 875



 Score =  127 bits (318), Expect = 3e-29
 Identities = 114/472 (24%), Positives = 171/472 (36%), Gaps = 116/472 (24%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C  G+ ++ +   C+DIDEC    + C+    C+N  G Y C       +  N      
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDR 1893

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
             +  E  +  + G+       +   +   GF AS       ++          R+P    
Sbjct: 1894 NECLEIPNVCSHGL-CVDLQGSYQCICHNGFKASQDQTMCMDVDE------CERHPCGNG 1946

Query: 148  RIPSNP-SHRIQCAAGYEQSEHNVCQDIDECTA---------------GTHNCRADQ--- 188
               +   S+   C  G+E + +N C DIDEC++               G+  C  ++   
Sbjct: 1947 TCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYE 2006

Query: 189  ------------------------VCINLRGSFACQCPPGYQKRGEQCVDIDECTIPP-- 222
                                     C NL GSF C CPPGY+ + E C+DI+EC   P  
Sbjct: 2007 LTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNI 2066

Query: 223  YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA-----SNQCA-QQCYNILGSFI 276
                 C NTPG F C C PGF L+ N   C D  +        + +C+  + +N   +  
Sbjct: 2067 CLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKC 2126

Query: 277  C--------------QCNQGYELSSDRL-------------NCEDIDECRTSSYLCQY-Q 308
            C               C +  E++   L               ED++EC  S  +C   Q
Sbjct: 2127 CCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQ 2186

Query: 309  CVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCY------- 360
            C+N  G F C CP GY +      C D +EC   N C  +  C N  G F C        
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIGSFECNCNEGFEP 2245

Query: 361  -PRNPCQD-------PYILT-------PENRCVCPVSNA------MCRELPQ 391
             P   C+D       P +             C CP+  A      MC++L +
Sbjct: 2246 GPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDE 2297



 Score =  105 bits (263), Expect = 7e-23
 Identities = 73/244 (29%), Positives = 106/244 (43%), Gaps = 39/244 (15%)

Query: 154  SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ-- 211
            S    C  G+E      C+DI+EC      C     C+N  GS+ C CP GY  R +Q  
Sbjct: 2234 SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR--CMNTFGSYECTCPIGYALREDQKM 2291

Query: 212  CVDIDECTIPPY-CHQR---CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ- 266
            C D+DEC    + C  R   C N  G+F C C PG     +   CVD NEC       + 
Sbjct: 2292 CKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICEN 2351

Query: 267  -QCYNILGSFICQCNQGYELSSDRLNCEDIDE-----------CRTSS----YLCQYQCV 310
             +C NI+GS+ C+CN+G++ SS    C D  +           C+ +S     + + +C 
Sbjct: 2352 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECC 2411

Query: 311  NEPGK---FSC-MCPQGYQVVRSRTC----------QDINECETTNECREDEMCWNYHGG 356
             + G+     C +CP        + C          +DI+EC+       +  C N  G 
Sbjct: 2412 CDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGS 2471

Query: 357  FRCY 360
            FRC+
Sbjct: 2472 FRCF 2475



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 47/140 (33%), Positives = 70/140 (50%), Gaps = 11/140 (7%)

Query: 153 PSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
           P+    C  G+  +     CQD+DEC A    C+    CIN  GSF C+CP G++  +  
Sbjct: 255 PAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGN-CINTVGSFECRCPAGHKQSETT 313

Query: 210 EQCVDIDECT-IPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVD--INECDA---SN 262
           ++C DIDEC+ IP  C    C NT GS++C C  G+  + +   C+D     C +   + 
Sbjct: 314 QKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNG 373

Query: 263 QCAQQCYNILGSFICQCNQG 282
           +CAQ+    +    C C  G
Sbjct: 374 RCAQELPGRMTKMQCCCEPG 393



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 44/120 (36%), Positives = 57/120 (47%), Gaps = 8/120 (6%)

Query: 212 CVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--Q 267
           C D+DEC  IP  C    C+NT GSF C+C  G + +     C DI+EC       +  +
Sbjct: 274 CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGE 333

Query: 268 CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE-PG---KFSCMCPQG 323
           C N +GS+ C C +GY  S+D   C D       S L   +C  E PG   K  C C  G
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 34/89 (38%), Positives = 46/89 (51%), Gaps = 3/89 (3%)

Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDID 296
           C  GF        C D++EC A     Q   C N +GSF C+C  G++ S     CEDID
Sbjct: 261 CRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDID 320

Query: 297 ECRTSSYLCQY-QCVNEPGKFSCMCPQGY 324
           EC     +C+  +C N  G + C+CP+GY
Sbjct: 321 ECSIIPGICETGECSNTVGSYFCVCPRGY 349



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 57/241 (23%), Positives = 83/241 (34%), Gaps = 72/241 (29%)

Query: 199 CQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN--TPGSFYCQCSPGF------QLAANNY 250
           C C  G          I +C++      RC+N  T    +CQC  G+      Q    N 
Sbjct: 130 CTCSSGQISSTCGSKSIQQCSV------RCMNGGTCADDHCQCQKGYIGTYCGQPVCEN- 182

Query: 251 TCVDINECDASNQCA-------------------------QQCYNILGSFICQ------- 278
            C +   C   N+CA                         Q C   L   +C        
Sbjct: 183 GCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCAT 242

Query: 279 ------------------CNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCM 319
                             C +G+  +     C+D+DEC+    +CQ   C+N  G F C 
Sbjct: 243 IGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECR 302

Query: 320 CPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-TPENRC 377
           CP G+ Q   ++ C+DI+EC       E   C N  G + C     C   Y+  T  +RC
Sbjct: 303 CPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCV----CPRGYVTSTDGSRC 358

Query: 378 V 378
           +
Sbjct: 359 I 359



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/188 (24%), Positives = 71/188 (37%), Gaps = 53/188 (28%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C  G+  D     C+D+DECD     C+ G  C N  GGY C     Q  + + Q  Q 
Sbjct: 2598 ECQRGFSLDATGLNCEDVDECD-GNHRCQHG--CQNILGGYRC--GCPQGYIQHYQWNQC 2652

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                E ++    G  +AS   T G                                    
Sbjct: 2653 VDENECSNPNACG--SASCYNTLG------------------------------------ 2674

Query: 148  RIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
                  S++  C +G+   +  + C D++EC++  + C  +  C N  G + C CPPGY 
Sbjct: 2675 ------SYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLCGCPPGYY 2726

Query: 207  KRGE-QCV 213
            + G+  CV
Sbjct: 2727 RVGQGHCV 2734



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 13/29 (44%), Positives = 19/29 (65%), Gaps = 1/29 (3%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLC 70
           C+D+DEC  +P  C+GG  C+N  G + C
Sbjct: 274 CQDVDECQAIPGICQGG-NCINTVGSFEC 301


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  182 bits (461), Expect = 8e-46
 Identities = 121/394 (30%), Positives = 178/394 (45%), Gaps = 57/394 (14%)

Query: 41   QCKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVN--------NEQPQ 85
            QC+DIDEC++ P  CK G+ CVN  G + C       L  T +I ++          + +
Sbjct: 907  QCEDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDE 965

Query: 86   QETQPAEG---------TSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
            + T P  G         + GA  G                         A  E+  G+  
Sbjct: 966  ECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPF 1025

Query: 137  FVIRRNPADPQRIPSNPSH----------RIQCAAGYE-QSEHNVCQDIDECTAGTHNCR 185
            F   ++  + + IPS  +H          + +C +G+   SE   C DIDEC      C 
Sbjct: 1026 F---KDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCG 1082

Query: 186  ADQVCINLRGSFACQCPPGYQK---RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCS 240
              Q C+N  G F C+C  GY+      + C+DIDEC   P   +   C NT GS+ C+C 
Sbjct: 1083 RGQ-CVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECP 1141

Query: 241  PGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDEC 298
            PG QL+ N   C+DINEC+ S       +C N++G + C CN GY  + DRL C DIDEC
Sbjct: 1142 PGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC 1201

Query: 299  RTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGF 357
               +  C+  C N  G + C C  G+ ++   R+C DI+ECE      +   C N  G +
Sbjct: 1202 SIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEY 1261

Query: 358  RCYPRNPCQDPYILTPENR-CV----CPVSNAMC 386
            RC     C D ++ + + + CV    C ++  +C
Sbjct: 1262 RCL----CYDGFMASEDMKTCVDVNECDLNPNIC 1291



 Score =  174 bits (440), Expect = 2e-43
 Identities = 106/340 (31%), Positives = 148/340 (43%), Gaps = 59/340 (17%)

Query: 44   DIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVA 103
            DIDEC ++ D C+ G +CVN  G Y C+ KT             T    GTS        
Sbjct: 2402 DIDECKVIHDVCRNG-ECVNDRGSYHCICKTGY-----------TPDITGTSCVDLNECN 2449

Query: 104  ASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGY 163
             +                              NF+ +             S++  C  GY
Sbjct: 2450 QAPKPC--------------------------NFICKNTEG---------SYQCSCPKGY 2474

Query: 164  E-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIP- 221
              Q +   C+D+DEC    HNC+   +C+N  G F C+CPPG+ +    C+D +ECT   
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQF--LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDI 2532

Query: 222  PYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQC 279
              C  +  C NTPGSF C+C  GF L     +C D++EC+ +++C   C NI+G + C C
Sbjct: 2533 NLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSC 2592

Query: 280  NQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINEC 338
             QGY        C D +EC ++       C N  G + CMCP G+Q  + S  CQDINEC
Sbjct: 2593 PQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINEC 2652

Query: 339  ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
             +  +      C N  GG+ C     C   Y    +  CV
Sbjct: 2653 GSA-QAPCSYGCSNTEGGYLC----GCPPGYFRIGQGHCV 2687



 Score =  171 bits (434), Expect = 1e-42
 Identities = 114/355 (32%), Positives = 154/355 (43%), Gaps = 25/355 (7%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY   P R  C DIDEC I+   C+    C N  G Y C  +    ++ +++   + 
Sbjct: 1182 CNPGYHSTPDRLFCVDIDECSIMNGGCE--TFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP---AD 145
               E       G    +       L   GF+AS       +M+T  +      NP     
Sbjct: 1240 DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASE------DMKTCVDVNECDLNPNICLS 1293

Query: 146  PQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
                 +  S    C  GY   +    C DI+EC  G HNC    VC N  GSF C C PG
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPG 1353

Query: 205  YQKRGEQCVDIDECTIPPYC---HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
            +   G +C D+DEC+   +    H  C NT GS+ C C  G+    + +TC D++EC  +
Sbjct: 1354 WIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY--TGDGFTCTDLDECSEN 1411

Query: 262  -NQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCM 319
             N C   QC N  G + C+C+ G+  S+D   CEDIDEC   +      C N PG F C 
Sbjct: 1412 LNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCE 1471

Query: 320  CPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP 373
            C  GY++ RS   C D+NEC     C     C N  G + C     C   + L P
Sbjct: 1472 CEIGYELDRSGGNCTDVNECLDPTTCISGN-CVNTPGSYIC----DCPPDFELNP 1521



 Score =  164 bits (415), Expect = 2e-40
 Identities = 122/403 (30%), Positives = 171/403 (42%), Gaps = 53/403 (13%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            QC +GYE  P  + C DI+EC + P  C  G  C N  G Y C+      +  NE+ +  
Sbjct: 1957 QCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYRCICPPGYSL-QNEKCEDI 2014

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
             +  E       G  + +  +   + P G  ++S+    G   Q  R ++   +      
Sbjct: 2015 DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSS----GRRCQDLRMSYCYAKFEGGKC 2070

Query: 148  RIPSNPSHRIQ-----------------CAAGYEQSEHNVCQ--------------DIDE 176
              P + +H  Q                 C    +++   +C               D+DE
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 177  CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTPGSF 235
            C      C+  Q CIN  GS+ C+CP GY   G +CVD DEC++   C +  C N  G F
Sbjct: 2131 CKE-PDVCKHGQ-CINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGF 2188

Query: 236  YCQCSPGFQLAANNYTCVDINECDASNQ--CAQQCYNILGSFICQCNQGYELSSDRLNCE 293
             C C  GF+      TC DINEC A N   CA +C N  GS+ C+C  GY L  DR  C+
Sbjct: 2189 ECTCEEGFE-PGPMMTCEDINEC-AQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246

Query: 294  DIDECRTSSYLC---QYQCVNEPGKFSCMCPQGYQ-VVRSRTCQDINECETTNECREDEM 349
            D DEC    + C   Q +C N  G + C+C  GYQ       C D NEC+T     E+  
Sbjct: 2247 DEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR 2306

Query: 350  CWNYHGGFRC-----YPRNPCQDPYILTPENRCVCPVSNAMCR 387
            C N  G + C     +  +P QD  +   E  C   V   MC+
Sbjct: 2307 CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQ 2349



 Score =  161 bits (408), Expect = 1e-39
 Identities = 89/213 (41%), Positives = 119/213 (55%), Gaps = 9/213 (4%)

Query: 154  SHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE-Q 211
            S R +C  G+  ++   VC+DIDEC  G   C+ +  CIN  GS+ C C PGY+     Q
Sbjct: 1788 SFRCECPVGFFYNDKLLVCEDIDECQNGPV-CQRNAECINTAGSYRCDCKPGYRFTSTGQ 1846

Query: 212  CVDIDECT-IPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCY 269
            C D +EC  IP  C H +C++T GSFYC C  GF+   +   C+DINEC+        C 
Sbjct: 1847 CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCR 1906

Query: 270  NILGSFICQCNQGYELSSDRLNCEDIDECRT-SSYLCQY-QCVNEPGKFSCMCPQGYQVV 327
            N +GSF C+CN G+ LS +  +C D+DEC + +  LC+  QC+N  G F C C +GY+V 
Sbjct: 1907 NTIGSFNCRCNHGFILSHNN-DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVA 1965

Query: 328  -RSRTCQDINECETTNECREDEMCWNYHGGFRC 359
               RTC DINEC           C N  G +RC
Sbjct: 1966 PDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC 1998



 Score =  159 bits (402), Expect = 5e-39
 Identities = 113/371 (30%), Positives = 157/371 (42%), Gaps = 44/371 (11%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGG-----------------------MKCVNH 64
           +C  G++ + V Q+C+DIDEC  +P  C+GG                        +C++ 
Sbjct: 272 KCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331

Query: 65  YGGYLCLPKTAQIIVNNEQPQQETQP---AEGTSGATTGVVAASSMATSGVLPGGGFVAS 121
             GY C         +N+ PQ  T+     +     + GV  A  M           + S
Sbjct: 332 RPGY-CYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCS 390

Query: 122 AAAVAG-----PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDI-- 174
              V       P    G    V+   P  P   P  P  R      Y   E      +  
Sbjct: 391 VPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPG-PQIPVPRPPVEYLYPSREPPRVLPVNV 449

Query: 175 -DECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQRCVNT 231
            D C    + C+  + CI   GS  C+C  G+Q   RGE C+D+DEC   P     C+N 
Sbjct: 450 TDYCQLVRYLCQNGR-CIPTPGSCRCECNKGFQLDLRGE-CIDVDECEKNPCAGGECINN 507

Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDR 289
            GS+ CQC  G+Q       C DI+EC  + +     +C N  GSF C CN G+ ++ D 
Sbjct: 508 QGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDG 567

Query: 290 LNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDE 348
            NCED+DEC   +      C+NE G F C+C  G+Q+    R C+DINECET   C    
Sbjct: 568 KNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR 627

Query: 349 MCWNYHGGFRC 359
            C N  G +RC
Sbjct: 628 -CVNTDGSYRC 637



 Score =  155 bits (393), Expect = 6e-38
 Identities = 101/322 (31%), Positives = 141/322 (43%), Gaps = 32/322 (9%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------PKTAQII 78
            C  G+   P ++ C DIDEC+  P+ C GG +C N  G Y CL           KT   +
Sbjct: 1223 CQPGFALMPDQRSCTDIDECEDNPNICDGG-QCTNIPGEYRCLCYDGFMASEDMKTCVDV 1281

Query: 79   VNNEQPQQETQPAEGTSGATTG-VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
              NE          GT   T G  +    M  SG               G    T  N  
Sbjct: 1282 --NECDLNPNICLSGTCENTKGSFICHCDMGYSGK-------------KGKTGCTDINEC 1326

Query: 138  VIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGS 196
             I  +      + +N +   +C+         + C D+DEC+ GTH C     C N  GS
Sbjct: 1327 EIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGS 1386

Query: 197  FACQCPPGYQKRGEQCVDIDECT--IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVD 254
            + C C  GY   G  C D+DEC+  +    + +C+N PG + C+C  GF  +A+   C D
Sbjct: 1387 YRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACED 1446

Query: 255  INECDASNQCA-QQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEP 313
            I+EC   N C    C+N+ G F C+C  GYEL     NC D++EC   +      CVN P
Sbjct: 1447 IDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTP 1506

Query: 314  GKFSCMCPQGYQVVRSRT-CQD 334
            G + C CP  +++  +R  C D
Sbjct: 1507 GSYICDCPPDFELNPTRVGCVD 1528



 Score =  153 bits (387), Expect = 3e-37
 Identities = 109/354 (30%), Positives = 149/354 (42%), Gaps = 66/354 (18%)

Query: 28   QCTDGYEWD-PVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
            +C +GYE    + + C DIDEC   P  C+GG+ C N  G Y C                
Sbjct: 1096 KCDEGYESGFMMMKNCMDIDECQRDPLLCRGGV-CHNTEGSYRC---------------- 1138

Query: 87   ETQPAEGTSGATTGVVAASSMATSGVL-PGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
            E  P    S   +  +  +    S  L P G  V                N +       
Sbjct: 1139 ECPPGHQLSPNISACIDINECELSAHLCPNGRCV----------------NLI------- 1175

Query: 146  PQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
                     ++  C  GY  +   + C DIDEC+     C  +  C N  GS+ C C PG
Sbjct: 1176 -------GKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC--ETFCTNSEGSYECSCQPG 1226

Query: 205  YQKRGEQ--CVDIDEC-TIPPYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA 260
            +    +Q  C DIDEC   P  C   +C N PG + C C  GF  + +  TCVD+NECD 
Sbjct: 1227 FALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDL 1286

Query: 261  S-NQC-AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKF 316
            + N C +  C N  GSFIC C+ GY     +  C DI+EC   ++ C     C N  G F
Sbjct: 1287 NPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSF 1346

Query: 317  SCMCPQGYQVVRSRTCQDINECET-TNECREDEMCWNYHGGFRCYPRNPCQDPY 369
             C C  G+ +     C D++EC   T+ C +   C N  G +RC     C++ Y
Sbjct: 1347 KCSCSPGW-IGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCL----CKEGY 1395



 Score =  139 bits (350), Expect = 6e-33
 Identities = 110/396 (27%), Positives = 158/396 (39%), Gaps = 51/396 (12%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY +    Q C D +EC  +P+ C  G +C++  G + CL  T      N+      
Sbjct: 1835 CKPGYRFTSTGQ-CNDRNECQEIPNICSHG-QCIDTVGSFYCLCHTG--FKTNDDQTMCL 1890

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAA--AVAGPEMQTGRNNFVIRRNPADP 146
               E    A       +++ +       GF+ S     +   E  +G  N        + 
Sbjct: 1891 DINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLC-----RNG 1945

Query: 147  QRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
            Q I +  S + QC  GYE + +   C DI+EC      C A   C NL GS+ C CPPGY
Sbjct: 1946 QCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKC-APGTCQNLDGSYRCICPPGY 2004

Query: 206  QKRGEQCVDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI-------- 255
              + E+C DIDEC   P       C NT GSF C C  GF L+++   C D+        
Sbjct: 2005 SLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAK 2064

Query: 256  ---NECD---ASNQCAQQCYNILGS-------------------FICQCNQGYELSSDRL 290
                +C    + N   Q+C   L                      IC    G  +  D  
Sbjct: 2065 FEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDD- 2123

Query: 291  NCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
            +  D+DEC+        QC+N  G + C CP GY ++    C D +EC   N C  +  C
Sbjct: 2124 SAVDMDECKEPDVCKHGQCINTDGSYRCECPFGY-ILAGNECVDTDECSVGNPC-GNGTC 2181

Query: 351  WNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMC 386
             N  GGF C      +   ++T E+   C  +  +C
Sbjct: 2182 KNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLC 2217



 Score =  139 bits (349), Expect = 8e-33
 Identities = 85/238 (35%), Positives = 114/238 (47%), Gaps = 25/238 (10%)

Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
           IP+  S R +C  G++      C D+DEC     N  A   CIN +GS+ CQC  GYQ  
Sbjct: 466 IPTPGSCRCECNKGFQLDLRGECIDVDECEK---NPCAGGECINNQGSYTCQCRAGYQST 522

Query: 209 --GEQCVDIDECTIPP-YCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
               +C DIDEC      C+  RC+NT GSF+C C+ GF +  +   C D++EC   N C
Sbjct: 523 LTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMC 582

Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
               C N  GSF C C  G++L+SD   C+DI+EC T       +CVN  G + C C  G
Sbjct: 583 LNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPG 642

Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDP-YILTPENRCVC 379
             V +  R C D +   T             +GG   Y R  C  P +    ++ C C
Sbjct: 643 LAVGLDGRVCVDTHMRSTC------------YGG---YKRGQCIKPLFGAVTKSECCC 685



 Score =  139 bits (349), Expect = 8e-33
 Identities = 122/446 (27%), Positives = 177/446 (39%), Gaps = 87/446 (19%)

Query: 44   DIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVA 103
            D+DEC   PD CK G +C+N  G Y C      I+  NE    +        G  T    
Sbjct: 2127 DMDECK-EPDVCKHG-QCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGT---- 2180

Query: 104  ASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP--ADPQRIPSNPSHRIQCAA 161
                    V+ G           GP M T  +     +NP     + + +  S+  +C  
Sbjct: 2181 -----CKNVIGGFECTCEEGFEPGP-MMTCEDINECAQNPLLCAFRCVNTYGSYECKCPV 2234

Query: 162  GYE-QSEHNVCQDIDECTAGTHNCRADQV-CINLRGSFACQCPPGYQKR--GEQCVDIDE 217
            GY  + +  +C+D DEC  G H+C   Q+ C NL G++ C C PGYQ+R  GE CVD +E
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENE 2294

Query: 218  C-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE------------------ 257
            C T P  C   RC+NT GS+ C+C+ GF  + N   C+D  E                  
Sbjct: 2295 CQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSN 2354

Query: 258  ----------CDASNQCAQQCY------NILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
                      CD        C        +    +C   +G+       N  DIDEC+  
Sbjct: 2355 RNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGF-----MTNGADIDECKVI 2409

Query: 302  SYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINEC-ETTNECREDEMCWNYHGGFR 358
              +C+  +CVN+ G + C+C  GY   +   +C D+NEC +    C  + +C N  G ++
Sbjct: 2410 HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPC--NFICKNTEGSYQ 2467

Query: 359  CYPRNPCQDPYILTPENR------------------CVCPVSNAMCRELPQSIVYKYMSI 400
            C     C   YIL  + R                  CV  +    C+  P      + S 
Sbjct: 2468 C----SCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCK-CPPGFTQHHTSC 2522

Query: 401  RSDRSVPSDIFQIQATTIYANTINTF 426
              +    SDI    +  I  NT  +F
Sbjct: 2523 IDNNECTSDINLCGSKGICQNTPGSF 2548



 Score =  135 bits (339), Expect = 1e-31
 Identities = 107/377 (28%), Positives = 157/377 (41%), Gaps = 64/377 (16%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQP-QQE 87
            C +G+E  P+   C+DI+EC   P  C    +CVN YG Y C      ++  + +  + E
Sbjct: 2192 CEEGFEPGPM-MTCEDINECAQNPLLC--AFRCVNTYGSYECKCPVGYVLREDRRMCKDE 2248

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ--------TGRNNFVI 139
             +  EG    T   +   ++           + +   + GP  Q           N    
Sbjct: 2249 DECEEGKHDCTEKQMECKNL-----------IGTYMCICGPGYQRRPDGEGCVDENECQT 2297

Query: 140  RRNPADPQR-IPSNPSHRIQCAAGYEQS-EHNVCQDIDE-----------CTAGTHN--- 183
            +    +  R + +  S+  +C  G+  S   + C D  E           C  G+ N   
Sbjct: 2298 KPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNP 2357

Query: 184  -CRADQVCINLRG--------------SFACQCP--PGYQKRGEQCVDIDEC-TIPPYCH 225
              +++  C   RG              +F   CP   G+   G    DIDEC  I   C 
Sbjct: 2358 VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNG---ADIDECKVIHDVCR 2414

Query: 226  Q-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQCAQQCYNILGSFICQCNQGY 283
               CVN  GS++C C  G+       +CVD+NEC+ A   C   C N  GS+ C C +GY
Sbjct: 2415 NGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGY 2474

Query: 284  ELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TN 342
             L  D  +C+D+DEC T  + CQ+ CVN  G F+C CP G+      +C D NEC +  N
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF-TQHHTSCIDNNECTSDIN 2533

Query: 343  ECREDEMCWNYHGGFRC 359
             C    +C N  G F C
Sbjct: 2534 LCGSKGICQNTPGSFTC 2550



 Score =  132 bits (331), Expect = 9e-31
 Identities = 102/375 (27%), Positives = 149/375 (39%), Gaps = 53/375 (14%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY     +  C DI+EC+I    C     C N  G + C      I  +  +     
Sbjct: 1307 CDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI-GDGIKCTDLD 1365

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
            + + GT   +      ++M +   L   G+          +  +   N        + Q 
Sbjct: 1366 ECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLC-----GNGQC 1420

Query: 149  IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ- 206
            + +   +R +C  G+  S +   C+DIDEC+    N      C NL G F C+C  GY+ 
Sbjct: 1421 LNAPGGYRCECDMGFVPSADGKACEDIDECSLP--NICVFGTCHNLPGLFRCECEIGYEL 1478

Query: 207  -KRGEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE--C---- 258
             + G  C D++EC  P  C    CVNTPGS+ C C P F+L      CVD     C    
Sbjct: 1479 DRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDI 1538

Query: 259  -----DASNQCAQQ---------CYNILGS------------------FICQCNQGYELS 286
                 +    C+ +         C   LG                    +C   +G+  +
Sbjct: 1539 RPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPN 1598

Query: 287  SDRLNCEDIDECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNEC 344
               +  EDIDEC+    LCQ  +C+N  G F C CP GY +   +R C D+NECET   C
Sbjct: 1599 PITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGIC 1658

Query: 345  REDEMCWNYHGGFRC 359
                 C+N  G + C
Sbjct: 1659 GPG-TCYNTVGNYTC 1672



 Score =  130 bits (327), Expect = 3e-30
 Identities = 101/360 (28%), Positives = 148/360 (41%), Gaps = 51/360 (14%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  G++     + CKDI+EC+  P  C  G +CVN  G Y C                E 
Sbjct: 598 CKPGFQLASDGRYCKDINECE-TPGICMNG-RCVNTDGSYRC----------------EC 639

Query: 89  QP--AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
            P  A G  G         S    G   G        AV   E       +     P  P
Sbjct: 640 FPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGE-PCQP 698

Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
               ++  ++  C++G   +      DI+EC      C  + +C NLRG++ C C  GY+
Sbjct: 699 CPAQNSAEYQALCSSGPGMTSAG--SDINECALDPDIC-PNGICENLRGTYKCICNSGYE 755

Query: 207 --KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
               G+ CVDI+EC +      + +C NTPGSF C C  GF    +  TC DI+EC++S 
Sbjct: 756 VDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSP 815

Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCED----------ID---ECRTSSYLCQYQC 309
                C N  GSFIC+C+    L   +  C +          ID   E   +    + QC
Sbjct: 816 CINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQC 875

Query: 310 VNEPG----------KFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            +  G          +   +C +GY  ++   C+DI+ECE      ++ +C N  G F+C
Sbjct: 876 CSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKC 935



 Score =  115 bits (289), Expect = 7e-26
 Identities = 111/418 (26%), Positives = 159/418 (38%), Gaps = 86/418 (20%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---------LPKTAQII 78
            +C  GYE D     C D++EC + P  C  G  CVN  G Y+C           +   + 
Sbjct: 1471 ECEIGYELDRSGGNCTDVNEC-LDPTTCISG-NCVNTPGSYICDCPPDFELNPTRVGCVD 1528

Query: 79   VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
              +     + +P  G +G T         A S  +  G   AS     G    T      
Sbjct: 1529 TRSGNCYLDIRP-RGDNGDT---------ACSNEIGVGVSKASCCCSLGKAWGT------ 1572

Query: 139  IRRNPADPQRIPSNPSHRIQCAAGYEQSEHN----VCQDIDECTAGTHNCRADQVCINLR 194
                P +     +   ++I C  G E    N    + +DIDEC      C+  + CIN  
Sbjct: 1573 ----PCEMCPAVNTSEYKILCPGG-EGFRPNPITVILEDIDECQELPGLCQGGK-CINTF 1626

Query: 195  GSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYT 251
            GSF C+CP GY    +   C D++EC  P  C    C NT G++ C C P +        
Sbjct: 1627 GSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNN 1686

Query: 252  CVDINE-------------CDAS---NQCAQQC---YNILGSFICQCNQGYELSSDRLNC 292
            C+D+               CD     N   + C   YNI  ++   C Q    S+D    
Sbjct: 1687 CMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFAT 1746

Query: 293  ------------------EDIDECRTSSYLCQY-QCVNEPGKFSCMCPQG-YQVVRSRTC 332
                               DIDECR    +C+   C+N  G F C CP G +   +   C
Sbjct: 1747 LCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVC 1806

Query: 333  QDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELP 390
            +DI+EC+    C+ +  C N  G +RC     C+  Y  T   +C        C+E+P
Sbjct: 1807 EDIDECQNGPVCQRNAECINTAGSYRC----DCKPGYRFTSTGQC---NDRNECQEIP 1857



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 85/333 (25%), Positives = 135/333 (40%), Gaps = 47/333 (14%)

Query: 25  TYT-QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ 83
           +YT QC  GY+    R +C+DIDEC      C  G +C+N  G + C+      +  + +
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG-RCINTDGSFHCVCNAGFHVTRDGK 568

Query: 84  PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP 143
             ++       +    G+      +   +   G  +AS         +       +    
Sbjct: 569 NCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICM---- 624

Query: 144 ADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDI---DECTAGTHN-----------CRADQ 188
            + + + ++ S+R +C  G     +  VC D      C  G               +++ 
Sbjct: 625 -NGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSEC 683

Query: 189 VCINLRGSFA--CQ-CP--------------PGYQKRGEQCVDIDECTI-PPYC-HQRCV 229
            C +   +F   CQ CP              PG    G    DI+EC + P  C +  C 
Sbjct: 684 CCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGS---DINECALDPDICPNGICE 740

Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSS 287
           N  G++ C C+ G+++ +    CVDINEC  ++      QC N  GSF+C C +G+    
Sbjct: 741 NLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKP 800

Query: 288 DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC 320
           D   CEDIDEC +S  +    C N PG F C C
Sbjct: 801 DLKTCEDIDECESSPCI-NGVCKNSPGSFICEC 832



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 47/140 (33%), Positives = 70/140 (50%), Gaps = 11/140 (7%)

Query: 153 PSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRG 209
           P+    C  G+  +     CQD+DEC A    C+    CIN  GSF C+CP G++  +  
Sbjct: 225 PAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGN-CINTVGSFECKCPAGHKLNEVS 283

Query: 210 EQCVDIDEC-TIPPYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDIN-----ECDASN 262
           ++C DIDEC TIP  C    C NT  S++C+C PGF  + +   C+D+          + 
Sbjct: 284 QKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNG 343

Query: 263 QCAQQCYNILGSFICQCNQG 282
           +C+ Q    +    C C+ G
Sbjct: 344 RCSNQLPQSITKMQCCCDAG 363



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 13/143 (9%)

Query: 212 CVDIDEC-TIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--Q 267
           C D+DEC  IP  C    C+NT GSF C+C  G +L   +  C DI+EC       +  +
Sbjct: 244 CQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGE 303

Query: 268 CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
           C N + S+ C+C  G+  S D   C D+      + L   +C N+        PQ   + 
Sbjct: 304 CTNTVSSYFCKCPPGFYTSPDGTRCIDVRPGYCYTALTNGRCSNQ-------LPQ--SIT 354

Query: 328 RSRTCQDINECETTNECREDEMC 350
           + + C D   C +       EMC
Sbjct: 355 KMQCCCDAGRCWSPGVTVAPEMC 377



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 36/101 (35%), Positives = 49/101 (48%), Gaps = 4/101 (3%)

Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDID 296
           C  GF        C D++EC A     Q   C N +GSF C+C  G++L+     CEDID
Sbjct: 231 CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDID 290

Query: 297 ECRTSSYLCQ-YQCVNEPGKFSCMCPQGYQVVRSRT-CQDI 335
           EC T   +C+  +C N    + C CP G+      T C D+
Sbjct: 291 ECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRCIDV 331



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 62/265 (23%), Positives = 95/265 (35%), Gaps = 81/265 (30%)

Query: 199 CQCPPGYQKRGEQCVDIDECTIPPYCHQRCVN--TPGSFYCQCSPGF------QLAANNY 250
           C CP G          I  C I      RC+N  +    +C C  G+      Q    + 
Sbjct: 100 CTCPSGQIAPSCGSRSIQHCNI------RCMNGGSCSDDHCLCQKGYIGTHCGQPVCES- 152

Query: 251 TCVDINECDASNQCA----------------QQCYNILGSFICQ---------------- 278
            C++   C A N+CA                  C+ ++ + +CQ                
Sbjct: 153 GCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCAT 212

Query: 279 ------------------CNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCM 319
                             C +G+  +     C+D+DEC+    LCQ   C+N  G F C 
Sbjct: 213 VGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECK 272

Query: 320 CPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-- 376
           CP G+++   S+ C+DI+EC T     E   C N    + C     C   +  +P+    
Sbjct: 273 CPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFC----KCPPGFYTSPDGTRC 328

Query: 377 -------CVCPVSNAMC-RELPQSI 393
                  C   ++N  C  +LPQSI
Sbjct: 329 IDVRPGYCYTALTNGRCSNQLPQSI 353



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 52/198 (26%), Positives = 73/198 (36%), Gaps = 54/198 (27%)

Query: 18   QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQI 77
            Q+T  + T  +C  G+  D     C+D+DEC+     C+ G  C N  GGY C     Q 
Sbjct: 2542 QNTPGSFT-CECQRGFSLDQTGSSCEDVDECE-GNHRCQHG--CQNIIGGYRC--SCPQG 2595

Query: 78   IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNF 137
             + + Q  Q     E  S    G   AS   T G                          
Sbjct: 2596 YLQHYQWNQCVDENECLSAHICG--GASCHNTLG-------------------------- 2627

Query: 138  VIRRNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGS 196
                            S++  C AG++  + +  CQDI+EC  G+        C N  G 
Sbjct: 2628 ----------------SYKCMCPAGFQYEQFSGGCQDINEC--GSAQAPCSYGCSNTEGG 2669

Query: 197  FACQCPPGYQKRGE-QCV 213
            + C CPPGY + G+  CV
Sbjct: 2670 YLCGCPPGYFRIGQGHCV 2687



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 19/43 (44%), Positives = 24/43 (55%), Gaps = 1/43 (2%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
            +C  G+  D   + C DIDEC I PD C  G +CVN  G + C
Sbjct: 1054 RCDSGFALDSEERNCTDIDECRISPDLCGRG-QCVNTPGDFEC 1095



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 13/29 (44%), Positives = 19/29 (65%), Gaps = 1/29 (3%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLC 70
           C+D+DEC  +P  C+GG  C+N  G + C
Sbjct: 244 CQDVDECQAIPGLCQGG-NCINTVGSFEC 271


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  181 bits (458), Expect = 2e-45
 Identities = 140/525 (26%), Positives = 216/525 (41%), Gaps = 77/525 (14%)

Query: 26   YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII--VNNEQ 83
            Y  C  G       + C+DIDEC +    C  G  C N  G Y C+ +        ++  
Sbjct: 5129 YCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGL 5188

Query: 84   PQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVI---R 140
              Q+    + +S        A      G  PG                 GR    +   R
Sbjct: 5189 SCQDINECQESSPCHQRCFNAIGSFHCGCEPG-------------YQLKGRKCMDVNECR 5235

Query: 141  RNPADPQRIPSNPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
            +N   P +   N     +    C  G  ++E+  C DIDEC  GTH CR +Q+C N RGS
Sbjct: 5236 QNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGS 5295

Query: 197  FACQCPPGYQKR--GEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            + C CP GY+ +  G  C+DI+EC  +P  C  +C NTPGSF C C PG  L  +  +C 
Sbjct: 5296 YRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCA 5355

Query: 254  DINECD-----------------ASNQCAQQCYNILGSFICQ------------------ 278
             +                      +N   QQ Y                           
Sbjct: 5356 GLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTI 5415

Query: 279  ---CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRS-RTCQD 334
               C +G E S D   C DIDEC  +   CQ++C N  G + C+CP GYQ+  + +TCQD
Sbjct: 5416 RKTCPEGSEASHD--TCVDIDECENTD-ACQHECKNTFGSYQCICPPGYQLTHNGKTCQD 5472

Query: 335  INEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP-ENRCV--CPVSNAMCRELP 390
            I+EC E    C  + MC+N  G ++C    PC   Y   P    C+  CP ++  C   P
Sbjct: 5473 IDECLEQNVHCGPNRMCFNMRGSYQCID-TPCPPNYQRDPVSGFCLKNCPPNDLECALSP 5531

Query: 391  QSIVYKYMSIRSDRSVPSDIFQIQATTI--YANTINTFRIKSGNENGEFYLRQTSPVSAM 448
             ++ YK +S+    +   D+ ++ A T     +   TF +    +   F LR  + +  +
Sbjct: 5532 YALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDEN-LKGV 5590

Query: 449  LVLVKSLSGPREHIVDLEMLTVSSIGT--FRTSSVLRLTIIVGPF 491
            +   + L     + + +   + S+ GT  ++T+ ++ + +   P+
Sbjct: 5591 VYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSAYPY 5635



 Score =  153 bits (387), Expect = 3e-37
 Identities = 87/230 (37%), Positives = 119/230 (51%), Gaps = 25/230 (10%)

Query: 158  QCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVD 214
            QC +G+   S    C D DEC AG         C N  G++ C CP G      G  C D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNP---CSHSCHNAMGTYYCSCPKGLTIAADGRTCQD 5147

Query: 215  IDECTIPPY-CH--QRCVNTPGSFYC--QCSPGFQLAANNYTCVDINECDASNQCAQQCY 269
            IDEC +  + CH  Q C NT GS+ C  +C  GF+  ++  +C DINEC  S+ C Q+C+
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQRCF 5207

Query: 270  NILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSC--MCPQGYQVV 327
            N +GSF C C  GY+L   +  C D++ECR +       C N  G + C  +CP G    
Sbjct: 5208 NAIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKA 5265

Query: 328  RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCY-PR--------NPCQD 367
             + TC DI+EC + T++CR +++C N  G +RC  PR         PC D
Sbjct: 5266 ENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMD 5315


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  179 bits (455), Expect = 4e-45
 Identities = 119/389 (30%), Positives = 175/389 (44%), Gaps = 50/389 (12%)

Query: 42   CKDIDECDIVPDACKGGMKCVNHYGGYLC-------LPKTAQIIVN----------NEQP 84
            C D++EC+  P  C  G +CVN  G + C       L  + ++ V+          +E  
Sbjct: 867  CDDVNECESFPGVCPNG-RCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDE 925

Query: 85   QQETQPAEG-------TSGATTGVVAAS-----SMATSGVLPGGGFVASAAAVAGPEMQT 132
               T P +        + GA  GV   +     S+  + + P G   AS   ++G     
Sbjct: 926  CGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYK 985

Query: 133  GRNNFVIRRNPADPQRIPSNP-SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVC 190
              N   +           +   S    CA G+   ++   C DIDEC      C     C
Sbjct: 986  DVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLC-GQGTC 1044

Query: 191  INLRGSFACQCPPGYQKRG---EQCVDIDECTIPPYCHQ--RCVNTPGSFYCQCSPGFQL 245
            +N  GSF C+C PGY+      + C+D+DEC   P   +   C NT GS+ CQC PG +L
Sbjct: 1045 VNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHEL 1104

Query: 246  AANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSY 303
             A    C DI+EC  S+      QC N++G+F C C+ G++ + DR  C DI+ECR  + 
Sbjct: 1105 TAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNG 1164

Query: 304  LCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECREDEMCWNYHGGFRCYPR 362
             C   C+N  G + C C QGY ++   R C D++ECE      +   C N  GG RC   
Sbjct: 1165 GCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCL-- 1222

Query: 363  NPCQDPYILTPENR-CV----CPVSNAMC 386
              C D ++ TP+ R CV    C ++  +C
Sbjct: 1223 --CYDGFMATPDMRTCVDVDECDLNPHIC 1249



 Score =  167 bits (423), Expect = 2e-41
 Identities = 86/227 (37%), Positives = 116/227 (51%), Gaps = 15/227 (6%)

Query: 159  CAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDE 217
            C  GY   E    C+D+DECT+  HNC+   +C+N  G+F C+CPPG+ +  + C D DE
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQACFDNDE 2488

Query: 218  CTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
            C+  P     H  C NTPGSF C+C  GF L ++ + C D+NECD  ++C   C N LG 
Sbjct: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGG 2548

Query: 275  FICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRS-RTC 332
            + C C QG+   S    C D +EC  S   C    C N  G F C+CP G+   ++   C
Sbjct: 2549 YRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGC 2608

Query: 333  QDINECE-TTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
            Q+++EC      C     C N  GGF C     C   Y    +  CV
Sbjct: 2609 QEVDECAGRRGPC--SYSCANTPGGFLC----GCPQGYFRAGQGHCV 2649



 Score =  166 bits (420), Expect = 4e-41
 Identities = 112/364 (30%), Positives = 164/364 (45%), Gaps = 43/364 (11%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G++  P RQ C DI+EC +    C   + C+N  G Y C       ++ + +   + 
Sbjct: 1140 CHAGFQSTPDRQGCVDINECRVQNGGCD--VHCINTEGSYRCSCGQGYSLMPDGRACADV 1197

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGG-------GFVASAAAVAGPEMQTGRNNFVIRR 141
               E         V      T+  +PGG       GF+A+      P+M+T  +      
Sbjct: 1198 DECEENPR-----VCDQGHCTN--MPGGHRCLCYDGFMAT------PDMRTCVDVDECDL 1244

Query: 142  NP-----ADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRG 195
            NP      D +   +  S    C  GY   +    C D+DEC  G HNC +   C+N+ G
Sbjct: 1245 NPHICLHGDCEN--TKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPG 1302

Query: 196  SFACQCPPGYQKRGEQCVDIDECTIPPY-CHQR--CVNTPGSFYCQCSPGFQLAANNYTC 252
            SF+C+C PG+   G +C D+DEC    + C  R  C+N PGS+ C C  GF  A + + C
Sbjct: 1303 SFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF--AGDGFFC 1360

Query: 253  VDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCV 310
             D +EC  +       QC N  G + C+C  G++ + D   C+D+DEC   +      C 
Sbjct: 1361 EDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCE 1420

Query: 311  NEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPY 369
            N PG F C+C  GY++ R    C DINEC     C  + +C N  G + C     C   +
Sbjct: 1421 NLPGMFRCICNGGYELDRGGGNCTDINECADPVNC-INGVCINTPGSYLC----SCPQDF 1475

Query: 370  ILTP 373
             L P
Sbjct: 1476 ELNP 1479



 Score =  159 bits (401), Expect = 7e-39
 Identities = 82/193 (42%), Positives = 106/193 (54%), Gaps = 8/193 (4%)

Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPYCHQRCV 229
           Q ID C   T+ C   + C+    S+ C+C  GY +  RGE C+D+DECT  P  H  CV
Sbjct: 407 QTIDICRHFTNLCLNGR-CLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGDCV 464

Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSS 287
           N PG+++C+C PGFQ       CVD++EC  S       +C N  GSF C CN G+ELS 
Sbjct: 465 NIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSP 524

Query: 288 DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV-RSRTCQDINECETTNECRE 346
           D  NC D +EC TS+      C+NE G FSC+C  G+ +      C DI+EC+T   C  
Sbjct: 525 DGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVN 584

Query: 347 DEMCWNYHGGFRC 359
              C N  G FRC
Sbjct: 585 GH-CTNTEGSFRC 596



 Score =  158 bits (399), Expect = 1e-38
 Identities = 130/439 (29%), Positives = 176/439 (40%), Gaps = 100/439 (22%)

Query: 28   QCTDGYEWD-PVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
            +C  GYE    + + C D+DEC   P  C+GG  C N  G Y C           + P  
Sbjct: 1054 ECFPGYESGFMLMKNCMDVDECARDPLLCRGG-TCTNTDGSYKC-----------QCPPG 1101

Query: 87   ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAV-----AGPEMQTGRNNFV--- 138
                A+GT+       + S     G+ P G  V    A      AG +    R   V   
Sbjct: 1102 HELTAKGTACEDIDECSLS----DGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDIN 1157

Query: 139  ---IRRNPADPQRIPSNPSHRIQCAAGY------------EQSEHN-------------- 169
               ++    D   I +  S+R  C  GY            ++ E N              
Sbjct: 1158 ECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPG 1217

Query: 170  -----------------VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
                              C D+DEC    H C     C N +GSF C C  GY  +K   
Sbjct: 1218 GHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGAT 1276

Query: 211  QCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQ 266
             C D+DEC +  +    H  C+N PGSF C+C PG+    + + C D++EC    ++C+ 
Sbjct: 1277 GCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGW--VGDGFECHDLDECVSQEHRCSP 1334

Query: 267  Q--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQG 323
            +  C N+ GS+ C C QG+  + D   CED DEC  +  LC   QC+N PG + C C  G
Sbjct: 1335 RGDCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMG 1392

Query: 324  YQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-------TPEN 375
            +      R CQD++EC   N C     C N  G FRC     C   Y L       T  N
Sbjct: 1393 FDPTEDHRACQDVDECAQGNLCAFGS-CENLPGMFRCI----CNGGYELDRGGGNCTDIN 1447

Query: 376  RCVCPVS--NAMCRELPQS 392
             C  PV+  N +C   P S
Sbjct: 1448 ECADPVNCINGVCINTPGS 1466



 Score =  157 bits (398), Expect = 2e-38
 Identities = 114/350 (32%), Positives = 151/350 (43%), Gaps = 38/350 (10%)

Query: 42   CKDIDECDIVPDACKGGMKCVNHYGGYLC--------LPKTAQIIVNNEQP---QQETQP 90
            C D +EC   PD C  G +CVN  G + C         P   +     + P   +     
Sbjct: 2250 CTDDNECHAQPDLCVNG-RCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTM 2308

Query: 91   AEGTSGATTGVVAASSMATSG----------VLPGGGFVASAAAVAGPEMQTGRNNFVIR 140
                S ++  V  A      G           LPG                 GR+    R
Sbjct: 2309 CRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECR 2368

Query: 141  RNP---ADPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
                  A  + I S  S R  C AGY   +    C D+DEC+     C    +C N +GS
Sbjct: 2369 MLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTF--LCKNTKGS 2426

Query: 197  FACQCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            F C CP GY  ++ G  C D+DECT   + C   CVNT G+F C+C PGF    ++  C 
Sbjct: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGF--TQHHQACF 2484

Query: 254  DINECDAS-NQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCV 310
            D +EC A    C     C+N  GSF C+C+QG+ L S    CED++EC    + CQ+ C 
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNEC-DGPHRCQHGCQ 2543

Query: 311  NEPGKFSCMCPQGY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            N+ G + C CPQG+ Q  +   C D NEC  +        C N  GGFRC
Sbjct: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRC 2593



 Score =  151 bits (382), Expect = 1e-36
 Identities = 106/368 (28%), Positives = 154/368 (41%), Gaps = 38/368 (10%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C  GY      + C+DIDEC      C  G  C N  G Y C+     + VN      +
Sbjct: 1589 ECPPGYHLSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYTCVCPAEYLQVNGGNNCMD 1647

Query: 88   TQPA------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGP----------EMQ 131
             + +       GT            M       G  +     A   P             
Sbjct: 1648 MRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQA 1707

Query: 132  TGRNNFVIRRNPADPQRIPSNP-------------SHRIQCAAGYEQSEHNV-CQDIDEC 177
             G    +    P D       P             S R +C AG+  +   + C+D+DEC
Sbjct: 1708 PGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDEC 1767

Query: 178  TAGTHNCRADQVCINLRGSFACQCPPGYQ-KRGEQCVDIDECT-IPPYC-HQRCVNTPGS 234
             +    C+ +  CIN+ GS+ C+C  GY+   G  CV  +EC  IP  C H  C++T GS
Sbjct: 1768 GSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGS 1827

Query: 235  FYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
            + C C  GFQ +A+   C+DI+ECD        C NI+GS+ C C  G+ ++ +  +C D
Sbjct: 1828 YMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNG-DCVD 1886

Query: 295  IDECRT-SSYLCQY-QCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCW 351
             DEC T    +C++  C+N  G F C+C  G+++    + C D NEC +         C 
Sbjct: 1887 FDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQ 1946

Query: 352  NYHGGFRC 359
            N  G FRC
Sbjct: 1947 NLEGSFRC 1954



 Score =  147 bits (372), Expect = 2e-35
 Identities = 81/208 (38%), Positives = 104/208 (50%), Gaps = 9/208 (4%)

Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
           +P+  S+R +C  GY Q     C D+DECT+    C     C+N+ G++ C+C PG+Q  
Sbjct: 425 LPTPSSYRCECNVGYTQDVRGECIDVDECTSSP--CHHGD-CVNIPGTYHCRCYPGFQAT 481

Query: 207 KRGEQCVDIDECTIP-PYCH-QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC 264
              + CVD+DEC +    CH  RCVNT GSF C C+ GF+L+ +   CVD NEC  S  C
Sbjct: 482 PTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMC 541

Query: 265 AQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
               C N  GSF C C  G+ L+     C DIDEC+T        C N  G F C C  G
Sbjct: 542 VNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGG 601

Query: 324 YQV-VRSRTCQDINECETTNECREDEMC 350
             V    R C D +   T     E   C
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSC 629



 Score =  147 bits (372), Expect = 2e-35
 Identities = 114/390 (29%), Positives = 154/390 (39%), Gaps = 56/390 (14%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G++       C DIDEC   P+ C  G  C N  G + CL     ++ +N     +T
Sbjct: 1956 CPPGFQVQS--DHCIDIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDT 2012

Query: 89   QPA-------EGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRR 141
            + +        G            +       PG G+                       
Sbjct: 2013 RQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGW----------------------- 2049

Query: 142  NPADPQRI-PSNPSHRIQ--CAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
               DP  + P   S   Q  C  G+       +  +D++EC      C  + VC+N  GS
Sbjct: 2050 --GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVC-TNGVCVNTDGS 2106

Query: 197  FACQCPPGYQK--RGEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCV 253
            F C+CP GY     G  CVD DEC++   C Q  C N  G F C C+ GF+      TC 
Sbjct: 2107 FRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLM-MTCE 2165

Query: 254  DINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQ---YQC 309
            DI+EC  +   CA +C+N  GS++C C  GY L  D   C D+DEC      C     +C
Sbjct: 2166 DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMEC 2225

Query: 310  VNEPGKFSCMCPQGYQVV--RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQD 367
             N  G F+C+CP G + +      C D NEC    +   +  C N  G FRC      Q 
Sbjct: 2226 KNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQP 2285

Query: 368  PYILTP-----ENRCVCPVSNAMCRELPQS 392
               LT      +  C   V   MCR L  S
Sbjct: 2286 SPTLTECHDIRQGPCFAEVLQTMCRSLSSS 2315



 Score =  147 bits (370), Expect = 3e-35
 Identities = 117/386 (30%), Positives = 161/386 (41%), Gaps = 48/386 (12%)

Query: 12   LALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDEC-DIVPDACKGGMKCVNHYGGYLC 70
            L   +  +TE +   T C  GY        C+D+DEC D   D    GM+C N  G + C
Sbjct: 2176 LCAFRCHNTEGSYLCT-CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFAC 2234

Query: 71   --------LPKTAQ-IIVNNEQPQQETQPAEGTSGATTGVV----------AASSMATSG 111
                    LP + +    +NE   Q      G    T G            + +      
Sbjct: 2235 VCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHD 2294

Query: 112  VLPGGGFV-----------ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA 160
            +  G  F            +S+ AV   E   G       R    P  +P   ++R  C 
Sbjct: 2295 IRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP--LPGTSAYRKLCP 2352

Query: 161  AGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGEQCVDIDEC 218
             G   +     +D+DEC    H C A   CIN  GSF C C  GY        C+D+DEC
Sbjct: 2353 HGSGYTAEG--RDVDECRMLAHLC-AHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409

Query: 219  T-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA-SNQCAQQCYNILGSFI 276
            + +P  C   C NT GSF C C  G+ L  +  TC D++EC +  + C   C N +G+F 
Sbjct: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469

Query: 277  CQCNQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSCMCPQGYQVVRS-RTCQ 333
            C+C  G+  +     C D DEC      C     C N PG F C C QG+ +V S   C+
Sbjct: 2470 CRCPPGF--TQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527

Query: 334  DINECETTNECREDEMCWNYHGGFRC 359
            D+NEC+  + C+    C N  GG+RC
Sbjct: 2528 DVNECDGPHRCQHG--CQNQLGGYRC 2551



 Score =  142 bits (357), Expect = 9e-34
 Identities = 118/403 (29%), Positives = 178/403 (44%), Gaps = 55/403 (13%)

Query: 19   DTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-------L 71
            +T E  T     +G++ + +    +DIDEC  +P  C+GG  CVN +G + C       L
Sbjct: 1538 NTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGG-DCVNTFGSFQCECPPGYHL 1596

Query: 72   PKTAQIIVNNEQPQQET-----QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVA 126
             +  +I  + ++    +          T G  T V  A  +  +G   G   +    +V 
Sbjct: 1597 SEHTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNG---GNNCMDMRKSVC 1653

Query: 127  GPEMQ-TGRNNFVIR----------------RNPADPQRIPSNPSHRIQC---AAGYEQS 166
                  T +N                       P +    P +P ++I C   A G+   
Sbjct: 1654 FRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTD 1713

Query: 167  EH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG--EQCVDIDEC-TIPP 222
             H     DIDEC      C A+ +CIN  GSF C+CP G+        C D+DEC +   
Sbjct: 1714 IHTGKPLDIDECGEIPAIC-ANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRES 1772

Query: 223  YCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQ-QCYNILGSFICQ 278
             C Q   C+N PGS+ C+C+ G++L+     CV  NEC +  N C+   C +  GS++C 
Sbjct: 1773 PCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCL 1831

Query: 279  CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINEC 338
            C++G++ S+D+  C DIDEC          C N  G ++C+C  G+ V  +  C D +EC
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQP-CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDEC 1890

Query: 339  ETT--NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV 378
             T     CR    C N  G F C     CQD + LT + + CV
Sbjct: 1891 TTLVGQVCRFGH-CLNTAGSFHCL----CQDGFELTADGKNCV 1928



 Score =  122 bits (306), Expect = 7e-28
 Identities = 115/378 (30%), Positives = 151/378 (39%), Gaps = 62/378 (16%)

Query: 43   KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVV 102
            +D++EC   P  C  G+ CVN  G + C           E P   +    G +   T   
Sbjct: 2083 EDVNECAENPGVCTNGV-CVNTDGSFRC-----------ECPFGYSLDFTGINCVDTDEC 2130

Query: 103  AASSMATSGVLPG--GGFVASAAAVAGPE-MQTGRNNFVIRRNPADPQRIPSNP--SHRI 157
            +       G      GGF  + A    P  M T  +      NP        N   S+  
Sbjct: 2131 SVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLC 2190

Query: 158  QCAAGYEQSEHN-VCQDIDECTAGTHNCRA-DQVCINLRGSFACQCPPGYQK---RGEQC 212
             C AGY   E   +C+D+DEC  G  +C A    C NL G+FAC CPPG +     GE C
Sbjct: 2191 TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGC 2250

Query: 213  VDIDECTIPP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYN 270
             D +EC   P    + RCVNT GSF C C  GFQ +     C DI +     +  Q    
Sbjct: 2251 TDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCR 2310

Query: 271  ILGSFI-------CQCNQG------YEL------SSDRLNC----------EDIDECRTS 301
             L S         C C  G       EL      S+ R  C           D+DECR  
Sbjct: 2311 SLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRML 2370

Query: 302  SYLCQY-QCVNEPGKFSCMCPQGYQV-VRSRTCQDINEC-ETTNECREDEMCWNYHGGFR 358
            ++LC + +C+N  G F C C  GY     + TC D++EC +    C    +C N  G F 
Sbjct: 2371 AHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPC--TFLCKNTKGSFL 2428

Query: 359  CYPRNPCQDPYILTPENR 376
            C     C   Y+L  + R
Sbjct: 2429 C----SCPRGYLLEEDGR 2442



 Score =  121 bits (303), Expect = 2e-27
 Identities = 105/387 (27%), Positives = 145/387 (37%), Gaps = 55/387 (14%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  G+   P    C DIDEC   P  C  G  C N  G + C       +  + +   +T
Sbjct: 557 CKPGFLLAPGGHYCMDIDECQ-TPGICVNG-HCTNTEGSFRCQCLGGLAVGTDGRVCVDT 614

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
                  GA      A           G    S    A P+   G             Q 
Sbjct: 615 HVRSTCYGAIEKGSCARPFP-------GTVTKSECCCANPDHGFGE----------PCQL 657

Query: 149 IPSNPSHRIQ--CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
            P+  S   Q  C++G   +     +DI+EC      C A+ VC NLRGS+ C C  GY+
Sbjct: 658 CPAKDSAEFQALCSSGLGITTDG--RDINECALDPEVC-ANGVCENLRGSYRCVCNLGYE 714

Query: 207 K--RGEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
               G+ C D+DEC +         C N+PGS+ C C PGF    +   C D++EC +S 
Sbjct: 715 AGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP 774

Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCED---------IDECRTSSYL----CQYQC 309
             +  C N+ GS+ C+C  G  L      C D         I E R    L     + +C
Sbjct: 775 CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSEC 834

Query: 310 VNEPG----------KFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
               G          +    C +G+  +   TC D+NECE+      +  C N  G FRC
Sbjct: 835 CATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC 894

Query: 360 YPRNPCQDPYILTPENRCVCPVSNAMC 386
                C +  +L    R    V    C
Sbjct: 895 ----ECPEGLMLDASGRLCVDVRLEPC 917



 Score =  119 bits (297), Expect = 8e-27
 Identities = 113/422 (26%), Positives = 165/422 (39%), Gaps = 70/422 (16%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-LPKTAQIIVNNE--QPQ 85
            C  GYE     + C D+DEC +    C  G  C N  G Y C  P       + E  +  
Sbjct: 709  CNLGYEAGASGKDCTDVDECALNSLLCDNGW-CQNSPGSYSCSCPPGFHFWQDTEICKDV 767

Query: 86   QETQPAEGTSGATTGVVAASSMAT---SGVLPGGGF-VASAAAVAGPEMQTGRNNFVIRR 141
             E   +   SG    +  + +      S + P G F + S       ++Q  R    ++ 
Sbjct: 768  DECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQG 827

Query: 142  NPADPQRIPS------NPSHRIQ----CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCI 191
                 +   +      +P  R +    CA G+ +     C D++EC +    C   + C+
Sbjct: 828  ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGR-CV 886

Query: 192  NLRGSFACQCPPGYQ--KRGEQCVDI-----------DEC--TIP-PYCHQRCVNTPGSF 235
            N  GSF C+CP G      G  CVD+           DEC  T+P  Y    C  + G+ 
Sbjct: 887  NTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAV 946

Query: 236  Y---CQCSP-------------GFQLAANNYTC-----VDINECDA-SNQCAQ-QCYNIL 272
            +   C+  P             G   A+ ++        D+NEC      C    C N +
Sbjct: 947  WGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTV 1006

Query: 273  GSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQ--VVRS 329
            GSF C C  G+ L +   NC DIDECR S  LC Q  CVN PG F C C  GY+   +  
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM 1066

Query: 330  RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV-----CPVSNA 384
            + C D++EC           C N  G ++C     C   + LT +         C +S+ 
Sbjct: 1067 KNCMDVDECARDPLLCRGGTCTNTDGSYKC----QCPPGHELTAKGTACEDIDECSLSDG 1122

Query: 385  MC 386
            +C
Sbjct: 1123 LC 1124



 Score =  114 bits (286), Expect = 2e-25
 Identities = 93/345 (26%), Positives = 143/345 (41%), Gaps = 37/345 (10%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTS----GA 97
           C+D+DEC  VP  C+GG  CVN  G + C       + ++    ++ +     S    G 
Sbjct: 245 CQDVDECQAVPGLCQGG-SCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303

Query: 98  TTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRI 157
             G +A            G   A+      PE+   R +   ++  A  QR+P  P H  
Sbjct: 304 CAGDLAGHYTRRQCCCDRGRCWAAGPV---PELCPPRGSNEFQQLCA--QRLPLLPGHPG 358

Query: 158 QCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP---PGYQKRG----E 210
                     + +   +       H            GS A   P   PG    G     
Sbjct: 359 LFPGLLGFGSNGMGPPLGPARLNPH------------GSDARGIPSLGPGNSNIGTATLN 406

Query: 211 QCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYN 270
           Q +DI         + RC+ TP S+ C+C+ G+        C+D++EC +S      C N
Sbjct: 407 QTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRG-ECIDVDECTSSPCHHGDCVN 465

Query: 271 ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQV-VR 328
           I G++ C+C  G++ +  R  C D+DEC  S  LC   +CVN  G F C+C  G+++   
Sbjct: 466 IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525

Query: 329 SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP 373
            + C D NEC T+  C  + +C N  G F C     C+  ++L P
Sbjct: 526 GKNCVDHNECATSTMC-VNGVCLNEDGSFSCL----CKPGFLLAP 565



 Score =  112 bits (280), Expect = 8e-25
 Identities = 123/465 (26%), Positives = 176/465 (37%), Gaps = 124/465 (26%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-LPKTAQI------IVNN 81
            C  GYE D     C DI+EC   P  C  G+ C+N  G YLC  P+  ++       V+ 
Sbjct: 1430 CNGGYELDRGGGNCTDINEC-ADPVNCINGV-CINTPGSYLCSCPQDFELNPSGVGCVDT 1487

Query: 82   EQPQQETQPAE-GTSGAT------TGVVAASSMATSG--------VLPGGGFVASAAAVA 126
                   +  + G SG +       GV  AS   + G        + P            
Sbjct: 1488 RAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCP 1547

Query: 127  GPEMQTGRNNFVIRRNPADPQRIP----------SNPSHRIQCAAGYEQSEHN-VCQDID 175
            G E        VI  +  + Q +P          +  S + +C  GY  SEH  +C+DID
Sbjct: 1548 GGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDID 1607

Query: 176  EC--------------TAGTHNC---------RADQVCINLRGSFA-------CQ----- 200
            EC              T G + C              C+++R S         CQ     
Sbjct: 1608 ECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAF 1667

Query: 201  -----------------------CP----PGYQKR-GEQC------------VDIDEC-T 219
                                   CP    P YQ   G Q             +DIDEC  
Sbjct: 1668 NVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGE 1727

Query: 220  IPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSF 275
            IP  C    C+N  GSF C+C  GF   +    C D++EC +     QQ   C NI GS+
Sbjct: 1728 IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSY 1787

Query: 276  ICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQVVRSRT-CQ 333
             C+C +GY+LS     C   +ECR    +C +  C++  G + C+C +G+Q    +T C 
Sbjct: 1788 RCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCM 1846

Query: 334  DINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCV 378
            DI+EC+   +   +  C N  G + C     C   +++T    CV
Sbjct: 1847 DIDECD--RQPCGNGTCKNIIGSYNCL----CFPGFVVTHNGDCV 1885



 Score =  111 bits (278), Expect = 1e-24
 Identities = 113/410 (27%), Positives = 151/410 (36%), Gaps = 78/410 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G++    +  C DIDECD  P  C  G  C N  G Y CL     ++ +N       
Sbjct: 1832 CHRGFQASADQTLCMDIDECDRQP--CGNGT-CKNIIGSYNCLCFPGFVVTHNGDCVDFD 1888

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN------ 142
            +         T +V         +   G F        G E+     N V          
Sbjct: 1889 E--------CTTLVGQVCRFGHCLNTAGSF--HCLCQDGFELTADGKNCVDTNECLSLAG 1938

Query: 143  ---PADPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFA 198
               P   Q +    S R  C  G++ QS+H  C DIDEC+   + C     C N  GSF 
Sbjct: 1939 TCLPGTCQNLEG--SFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFG-TCTNSPGSFQ 1993

Query: 199  CQCPPGY--QKRGEQCVDIDE-----------CTIPPYCHQR-----CVNTPGSFY---C 237
            C CPPG+     G +C D  +           C++P   +       C   PG  +   C
Sbjct: 1994 CLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPC 2053

Query: 238  QCSPGFQLAANNYTCV--------------DINEC-DASNQCAQQ-CYNILGSFICQCNQ 281
            +  P    AA    C               D+NEC +    C    C N  GSF C+C  
Sbjct: 2054 ELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPF 2113

Query: 282  GYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETT 341
            GY L    +NC D DEC       Q  C N  G F C C  G++     TC+DI+EC + 
Sbjct: 2114 GYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDEC-SL 2172

Query: 342  NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQ 391
            N       C N  G + C     C   Y L  +         AMCR++ +
Sbjct: 2173 NPLLCAFRCHNTEGSYLC----TCPAGYTLRED--------GAMCRDVDE 2210



 Score =  110 bits (275), Expect = 3e-24
 Identities = 98/373 (26%), Positives = 138/373 (36%), Gaps = 93/373 (24%)

Query: 26  YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
           + +C  G++  P RQ C D+DEC +    C  G +CVN  G + C+              
Sbjct: 471 HCRCYPGFQATPTRQACVDVDECIVSGGLCHLG-RCVNTEGSFQCVCNAG---------- 519

Query: 86  QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
            E  P +G +       A S+M  +GV                                 
Sbjct: 520 FELSP-DGKNCVDHNECATSTMCVNGVC-------------------------------- 546

Query: 146 PQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG 204
              +  + S    C  G+  +   + C DIDEC   T     +  C N  GSF CQC  G
Sbjct: 547 ---LNEDGSFSCLCKPGFLLAPGGHYCMDIDECQ--TPGICVNGHCTNTEGSFRCQCLGG 601

Query: 205 YQ--KRGEQCVDIDE---------------------------CTIPPY-----CHQRCVN 230
                 G  CVD                              C  P +     C      
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAK 661

Query: 231 TPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQ-QCYNILGSFICQCNQGYELSSD 288
               F   CS G  +  +     DINEC    + CA   C N+ GS+ C CN GYE  + 
Sbjct: 662 DSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRGSYRCVCNLGYEAGAS 718

Query: 289 RLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNECRE 346
             +C D+DEC  +S LC    C N PG +SC CP G+   + +  C+D++EC  ++ C  
Sbjct: 719 GKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPC-V 776

Query: 347 DEMCWNYHGGFRC 359
             +C N  G + C
Sbjct: 777 SGVCRNLAGSYTC 789



 Score =  104 bits (260), Expect = 2e-22
 Identities = 114/436 (26%), Positives = 155/436 (35%), Gaps = 108/436 (24%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
           +C  GY  D VR +C D+DEC   P  C  G  CVN  G Y C             P  +
Sbjct: 434 ECNVGYTQD-VRGECIDVDECTSSP--CHHG-DCVNIPGTYHC----------RCYPGFQ 479

Query: 88  TQPAEGTSGATTGVVAASSMATSG--VLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
             P           + +  +   G  V   G F       AG E+     N V       
Sbjct: 480 ATPTRQACVDVDECIVSGGLCHLGRCVNTEGSF--QCVCNAGFELSPDGKNCV------- 530

Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
                                +HN C     C  G        VC+N  GSF+C C PG+
Sbjct: 531 ---------------------DHNECATSTMCVNG--------VCLNEDGSFSCLCKPGF 561

Query: 206 --QKRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDI------- 255
                G  C+DIDEC  P  C +  C NT GSF CQC  G  +  +   CVD        
Sbjct: 562 LLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCY 621

Query: 256 ------------------NECDASN------QCAQQC-YNILGSFICQCNQGYELSSDRL 290
                             +EC  +N      +  Q C       F   C+ G  +++D  
Sbjct: 622 GAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG- 680

Query: 291 NCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRS-RTCQDINECETTNECREDE 348
              DI+EC     +C    C N  G + C+C  GY+   S + C D++EC   +   ++ 
Sbjct: 681 --RDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG 738

Query: 349 MCWNYHGGFRCYPRNPC-------QDPYILTPENRCV-CPVSNAMCRELPQSIVYKYMSI 400
            C N  G + C     C       QD  I    + C+  P  + +CR L  S  Y     
Sbjct: 739 WCQNSPGSYSC----SCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGS--YTCKCG 792

Query: 401 RSDRSVPSDIFQIQAT 416
              R  PS  F + +T
Sbjct: 793 PGSRLDPSGTFCLDST 808



 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 75/265 (28%), Positives = 107/265 (40%), Gaps = 24/265 (9%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY  D     C D+DEC  VP  C     C N  G +LC      ++      +++ 
Sbjct: 2390 CQAGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLL------EEDG 2441

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNP----A 144
            +  +     T+       +  + V   G F            Q   +N      P    A
Sbjct: 2442 RTCKDLDECTSRQHNCQFLCVNTV---GAFTCRCPPGFTQHHQACFDNDECSAQPGPCGA 2498

Query: 145  DPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
                  +  S R +C  G+   S  + C+D++EC  G H C+    C N  G + C CP 
Sbjct: 2499 HGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQ--HGCQNQLGGYRCSCPQ 2555

Query: 204  GYQKRGE--QCVDIDECTI-PPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINEC- 258
            G+ +  +  QCVD +EC + PP C    C NT G F C C  GF        C +++EC 
Sbjct: 2556 GFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECA 2615

Query: 259  DASNQCAQQCYNILGSFICQCNQGY 283
                 C+  C N  G F+C C QGY
Sbjct: 2616 GRRGPCSYSCANTPGGFLCGCPQGY 2640



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 108/451 (23%), Positives = 152/451 (33%), Gaps = 112/451 (24%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC--LPKTA----QIIVNNE 82
            C  GY        C D+DEC++    C     C+N  G + C  LP       +    +E
Sbjct: 1265 CQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDE 1324

Query: 83   QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN 142
               QE + +    G    V  +          G GF           +    N       
Sbjct: 1325 CVSQEHRCSP--RGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNG------ 1376

Query: 143  PADPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGT-------------------- 181
                Q + +   +R +C  G++ +E H  CQD+DEC  G                     
Sbjct: 1377 ----QCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNG 1432

Query: 182  --------HNCR-----------ADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTI 220
                     NC             + VCIN  GS+ C CP  ++    G  CVD      
Sbjct: 1433 GYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNC 1492

Query: 221  PPYCHQR-------------------CVNTPGSFY---CQCSP---------------GF 243
                H R                   C  + G  +   C+  P               GF
Sbjct: 1493 FLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGF 1552

Query: 244  QLAANNYTCVDINECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTS 301
            Q         DI+EC       Q   C N  GSF C+C  GY LS     CEDIDEC T 
Sbjct: 1553 QPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTH 1612

Query: 302  SYLC-QYQCVNEPGKFSCMCPQGY-QVVRSRTCQDINEC---ETTNECREDEMCWNYHGG 356
            S +C    C N  G ++C+CP  Y QV     C D+ +       N   ++E+ +N    
Sbjct: 1613 SGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRK 1672

Query: 357  FRCYPRN-------PCQD-PYILTPENRCVC 379
              C   N       PC+  P  ++P+ + +C
Sbjct: 1673 MCCCSYNIGQAWNRPCEACPTPISPDYQILC 1703



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 65/238 (27%), Positives = 87/238 (36%), Gaps = 32/238 (13%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC-----LPKTAQIIVNNEQ 83
            C  GY  +   + CKD+DEC      C+    CVN  G + C       +  Q   +N++
Sbjct: 2431 CPRGYLLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTCRCPPGFTQHHQACFDNDE 2488

Query: 84   PQQETQP--AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGP-EMQTGRNNFVIR 140
               +  P  A G    T G           ++  G          GP   Q G  N +  
Sbjct: 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQL-- 2546

Query: 141  RNPADPQRIPSNPSHRIQCAAGYEQ-SEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
                          +R  C  G+ Q S+   C D +EC      C     C N  G F C
Sbjct: 2547 ------------GGYRCSCPQGFTQHSQWAQCVDENECALSPPTC-GSASCRNTLGGFRC 2593

Query: 200  QCPPGY---QKRGEQCVDIDECT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
             CP G+   Q  G  C ++DEC      C   C NTPG F C C  G+  A   + CV
Sbjct: 2594 VCPSGFDFDQALG-GCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGH-CV 2649



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 71/282 (25%), Positives = 98/282 (34%), Gaps = 55/282 (19%)

Query: 153 PSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ 211
           P+    C  G+  + H   CQD+DEC A    C+    C+N+ GSF C+CP G++     
Sbjct: 226 PAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSS 284

Query: 212 CVDID---ECTIPPYCHQRCVNTPGSFY----CQCSPGFQLAANNY--TCVDINECDASN 262
               D             RC       Y    C C  G   AA      C      +   
Sbjct: 285 AACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQ 344

Query: 263 QCAQQCYNILGS--------FICQCNQGYELSSDRLN----------------------- 291
            CAQ+   + G                G  L   RLN                       
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404

Query: 292 -CEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEM 349
             + ID CR  + LC   +C+  P  + C C  GY       C D++EC T++ C   + 
Sbjct: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC-TSSPCHHGD- 462

Query: 350 CWNYHGGFRCYPRNPCQDPYILTPENR-CV----CPVSNAMC 386
           C N  G + C     C   +  TP  + CV    C VS  +C
Sbjct: 463 CVNIPGTYHC----RCYPGFQATPTRQACVDVDECIVSGGLC 500



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 46/188 (24%), Positives = 64/188 (34%), Gaps = 52/188 (27%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            +C  G+        C+D++ECD  P  C+ G  C N  GGY C             PQ  
Sbjct: 2512 ECHQGFTLVSSGHGCEDVNECD-GPHRCQHG--CQNQLGGYRC-----------SCPQGF 2557

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
            TQ ++          A S        P  G  +    + G                    
Sbjct: 2558 TQHSQWAQCVDENECALSP-------PTCGSASCRNTLGG-------------------- 2590

Query: 148  RIPSNPSHRIQCAAGYEQSEH-NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
                    R  C +G++  +    CQ++DEC      C     C N  G F C CP GY 
Sbjct: 2591 -------FRCVCPSGFDFDQALGGCQEVDECAGRRGPC--SYSCANTPGGFLCGCPQGYF 2641

Query: 207  KRGE-QCV 213
            + G+  CV
Sbjct: 2642 RAGQGHCV 2649



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 51/218 (23%), Positives = 77/218 (35%), Gaps = 40/218 (18%)

Query: 153 PSHRIQCAAGYEQSEHNVCQDIDECTAGT----HNCRADQVCIN---LRGSFACQCPPGY 205
           P  R  C  G+  S+ N+C   D   A +            C+N    RG+ +C C  GY
Sbjct: 84  PICRRACGEGF-CSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGA-SCLCQKGY 141

Query: 206 QKRGEQCVDIDECTIPPYCHQRCVNTP---GSFYCQCSPGFQLAANNYTCVDINECDASN 262
              G  C         P C + C N     G   C C  GF             +C+   
Sbjct: 142 T--GTVCGQ-------PICDRGCHNGGRCIGPNRCACVYGFMGP----------QCERDY 182

Query: 263 QCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQ 322
           +    C+  +G   CQ      + +  L C  +   R     C+  C  +P      C +
Sbjct: 183 RTGP-CFGQVGPEGCQHQLTGLVCTKALCCATVG--RAWGLPCEL-CPAQPHP----CRR 234

Query: 323 GY-QVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           G+   + +  CQD++EC+      +   C N  G F C
Sbjct: 235 GFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHC 272



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 15/43 (34%), Positives = 19/43 (44%), Gaps = 2/43 (4%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
            +C  GY  D     C D DEC +     +G   C N  GG+ C
Sbjct: 2110 ECPFGYSLDFTGINCVDTDECSVGHPCGQG--TCTNVIGGFEC 2150


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  167 bits (423), Expect = 2e-41
 Identities = 109/379 (28%), Positives = 149/379 (39%), Gaps = 97/379 (25%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C+ GY+  P +  C D +EC  + D CKG  +C+N  G Y C       +          
Sbjct: 872  CSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRCINRVGSYSCFCYPGYTL---------- 919

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
                 TSGAT      +     GV  GG                              Q 
Sbjct: 920  ----ATSGATQECQDINECEQPGVCSGG------------------------------QC 945

Query: 149  IPSNPSHRIQCAAGYEQSEHNVCQDIDECT-AGTHNCRADQVCINLRGSFAC-QCPPGYQ 206
              +  S+  +C  GY       CQDI+EC   GT  C  D  C+N  GS+ C  C  GY+
Sbjct: 946  TNTEGSYHCECDQGYIMVRKGHCQDINECRHPGT--C-PDGRCVNSPGSYTCLACEEGYR 1002

Query: 207  KRGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC- 264
             +   CVD++EC  P  C H +C N  GSF C C  G+++ ++   C D++EC +   C 
Sbjct: 1003 GQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCP 1062

Query: 265  AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDEC-------------RTSSYLCQ---- 306
               C N  GSF C  C  GY ++ D   CED+DEC                S+ C+    
Sbjct: 1063 TGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDG 1122

Query: 307  --------------------------YQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET 340
                                       +C N  G + C+CPQG+Q+     C+D+NEC  
Sbjct: 1123 GYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMG 1182

Query: 341  TNECREDEMCWNYHGGFRC 359
               C     C N HG F C
Sbjct: 1183 EEHCAPHGECLNSHGSFFC 1201



 Score =  164 bits (415), Expect = 2e-40
 Identities = 109/379 (28%), Positives = 168/379 (44%), Gaps = 32/379 (8%)

Query: 25   TYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQP 84
            T   C +GY        C D++EC + P  C  G KC N  G + C  +    + ++E+ 
Sbjct: 993  TCLACEEGYRGQS--GSCVDVNEC-LTPGVCAHG-KCTNLEGSFRCSCEQGYEVTSDEKG 1048

Query: 85   QQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPA 144
             Q+       +   TG+   +  + +      G+  +    A  ++       V      
Sbjct: 1049 CQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVC----- 1103

Query: 145  DPQRIPSNPSHRIQCA---AGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
             P  + +N +    C     GY  S   + C+D+DEC     +C   + C N  GS+ C 
Sbjct: 1104 -PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTVGSYQCL 1161

Query: 201  CPPGYQ-KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
            CP G+Q   G  C D++EC    +C  H  C+N+ GSF+C C+PGF  A    +C D++E
Sbjct: 1162 CPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221

Query: 258  CDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRT-SSYLC-QYQCVNEPG 314
            C  ++ C    C N  GSF C C  G++ S +   C DIDEC      +C  ++C N PG
Sbjct: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG 1281

Query: 315  KFSCM--CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT 372
             + C+  C  G+ +  +  C DI+EC     C     C N  G FRC     C   + ++
Sbjct: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCL----CDQGFEIS 1337

Query: 373  PEN-RCV----CPVSNAMC 386
            P    CV    C +  A+C
Sbjct: 1338 PSGWDCVDVNECELMLAVC 1356



 Score =  149 bits (375), Expect = 7e-36
 Identities = 82/210 (39%), Positives = 114/210 (54%), Gaps = 14/210 (6%)

Query: 174  IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQ-RCVN 230
            ID C AG  N      C+NL   + C C PGYQ    Q  C D +EC   P   + RC+N
Sbjct: 845  IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 231  TPGSFYCQCSPGFQLAANNYT--CVDINECDASNQCA-QQCYNILGSFICQCNQGYELSS 287
              GS+ C C PG+ LA +  T  C DINEC+    C+  QC N  GS+ C+C+QGY +  
Sbjct: 905  RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY-IMV 963

Query: 288  DRLNCEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECRE 346
             + +C+DI+ECR        +CVN PG ++C+ C +GY+  +S +C D+NEC T   C  
Sbjct: 964  RKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLTPGVCAH 1022

Query: 347  DEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
             + C N  G FRC     C+  Y +T + +
Sbjct: 1023 GK-CTNLEGSFRC----SCEQGYEVTSDEK 1047



 Score =  143 bits (360), Expect = 4e-34
 Identities = 92/258 (35%), Positives = 122/258 (47%), Gaps = 30/258 (11%)

Query: 154  SHRIQCAAGYEQSEHNV---CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY-QKRG 209
            S+   C  GY  +       CQDI+EC      C   Q C N  GS+ C+C  GY   R 
Sbjct: 908  SYSCFCYPGYTLATSGATQECQDINECEQ-PGVCSGGQ-CTNTEGSYHCECDQGYIMVRK 965

Query: 210  EQCVDIDECTIPPYCHQ-RCVNTPGSFYC-QCSPGFQLAANNYTCVDINECDASNQCAQ- 266
              C DI+EC  P  C   RCVN+PGS+ C  C  G++    + +CVD+NEC     CA  
Sbjct: 966  GHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTPGVCAHG 1023

Query: 267  QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSC-MCPQGYQ 325
            +C N+ GSF C C QGYE++SD   C+D+DEC + +      C+N  G F+C  C  GY 
Sbjct: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083

Query: 326  VVRSRT-CQDINECETTNECREDEMCWNYHGGFRC------YPRNP----------CQDP 368
            V    T C+D++EC     C    +C N  G F C      Y  +P          C+DP
Sbjct: 1084 VNEDGTACEDLDECAFPGVC-PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDP 1142

Query: 369  YILTPENRCVCPVSNAMC 386
                    C   V +  C
Sbjct: 1143 QSSCLGGECKNTVGSYQC 1160



 Score =  139 bits (351), Expect = 4e-33
 Identities = 101/313 (32%), Positives = 133/313 (42%), Gaps = 61/313 (19%)

Query: 19   DTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII 78
            +T  + +   C  GY   P+   C+D+DEC+    +C GG +C N  G Y CL       
Sbjct: 1110 NTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG-ECKNTVGSYQCLCP----- 1163

Query: 79   VNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFV 138
                   Q  Q A GT            M      P G                      
Sbjct: 1164 -------QGFQLANGTVCEDVN----ECMGEEHCAPHG---------------------- 1190

Query: 139  IRRNPADPQRIPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSF 197
                    + + S+ S    CA G+  +E    CQD+DEC A T  C     C+N  GSF
Sbjct: 1191 --------ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDEC-ATTDPCVGGH-CVNTEGSF 1240

Query: 198  ACQCPPGYQKRGE--QCVDIDECTI--PPYCHQ-RCVNTPGSFYCQ--CSPGFQLAANNY 250
             C C  G+Q   E  +CVDIDEC     P C   +C N+PGS+ C   C PGF +A N  
Sbjct: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG- 1299

Query: 251  TCVDINECDASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLC-QY 307
             C+DI+EC     C     C N  GSF C C+QG+E+S    +C D++EC     +C   
Sbjct: 1300 DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAA 1359

Query: 308  QCVNEPGKFSCMC 320
             C N  G F C+C
Sbjct: 1360 LCENVEGSFLCLC 1372



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 41/129 (31%), Positives = 59/129 (45%), Gaps = 9/129 (6%)

Query: 253 VDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVN 311
           +D     A+N C    C N+   + C C+ GY+L   +  C D +EC       + +C+N
Sbjct: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904

Query: 312 EPGKFSCMCPQGYQVVRS---RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDP 368
             G +SC C  GY +  S   + CQDINECE    C   + C N  G + C     C   
Sbjct: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQ-CTNTEGSYHC----ECDQG 959

Query: 369 YILTPENRC 377
           YI+  +  C
Sbjct: 960 YIMVRKGHC 968



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 61/245 (24%), Positives = 91/245 (37%), Gaps = 25/245 (10%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------P 72
            C  G+E  P    C D++EC+++   C G   C N  G +LCL                P
Sbjct: 1330 CDQGFEISPSGWDCVDVNECELMLAVC-GAALCENVEGSFLCLCASDLEEYDAQEGHCRP 1388

Query: 73   KTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQT 132
            + A     +E P  +  PA       +G         S VL      A      G     
Sbjct: 1389 RGAGGQSMSEAPTGDHAPAPTRMDCYSG--QKGHAPCSSVLGRNTTQAECCCTQGASWGD 1446

Query: 133  GRNNFVIRRNPADPQRIPSNPSH-RIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCI 191
              +      +    +  PS   +  ++ A  + Q+ +    D DEC         +  C+
Sbjct: 1447 ACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT---DADECVIFGPGLCPNGRCL 1503

Query: 192  NLRGSFACQCPPG--YQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANN 249
            N    + C C PG  Y    ++C D DEC      +  CVNT GSF+C CSP   L  + 
Sbjct: 1504 NTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563

Query: 250  YTCVD 254
              C++
Sbjct: 1564 QRCMN 1568



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 72/319 (22%), Positives = 103/319 (32%), Gaps = 36/319 (11%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC---------LPKTAQIIV 79
            C  G++  P   +C DIDEC+   D   G  KC N  G Y C         +      I 
Sbjct: 1244 CETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCID 1303

Query: 80   NNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASA------AAVAGPEMQTG 133
             +E        + G    T G           + P G             AV G  +   
Sbjct: 1304 IDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCEN 1363

Query: 134  RNNFVIRRNPADPQRIPSNPSH-RIQCAAGYEQSE-----HNVCQDIDECTAGTHNCRAD 187
                 +    +D +   +   H R + A G   SE     H       +C +G    +  
Sbjct: 1364 VEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ---KGH 1420

Query: 188  QVCINLRG----SFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGF 243
              C ++ G       C C  G    G+ C   D C          +   G  Y      +
Sbjct: 1421 APCSSVLGRNTTQAECCCTQG-ASWGDAC---DLCPSEDSAEFSEICPSGKGYIPVEGAW 1476

Query: 244  QLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS 302
                  YT  D         C   +C N +  ++C CN G+   +    CED DEC+   
Sbjct: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--D 1534

Query: 303  YLCQY-QCVNEPGKFSCMC 320
              C+  +CVN  G F C C
Sbjct: 1535 LACENGECVNTEGSFHCFC 1553



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 33/90 (36%), Positives = 43/90 (47%), Gaps = 6/90 (6%)

Query: 209  GEQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCA-- 265
            G + +  +EC I   C   RCV     + C C  GFQL A +  CVD+NECD  N  A  
Sbjct: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL 1787

Query: 266  ---QQCYNILGSFICQCNQGYELSSDRLNC 292
                 C N  GS+ C C+ GY   +   +C
Sbjct: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 36/127 (28%), Positives = 51/127 (40%), Gaps = 7/127 (5%)

Query: 200 QCPPGYQKRG-EQCVDIDECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
           +CP GY++     C DI+EC     C    CVNT GS+ C C PG  L  +   CV    
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK- 665

Query: 258 CDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFS 317
             A +     CY  LG   C       ++     C  + +   S   C+   +     F 
Sbjct: 666 --AISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFR 721

Query: 318 CMCPQGY 324
            +CP G+
Sbjct: 722 EICPAGH 728



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 34/122 (27%), Positives = 50/122 (40%), Gaps = 16/122 (13%)

Query: 139  IRRNPADPQRI-PSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSF 197
            I  +P  P  + P   +   +  AG+E  +   C  ++ C  G         C+ +R  +
Sbjct: 1704 ILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGR--------CVRVREGY 1755

Query: 198  ACQCPPGYQKRGEQ--CVDIDEC-----TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNY 250
             C C  G+Q       CVD++EC           H  C NT GS+ C CSPG+   A   
Sbjct: 1756 TCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPP 1815

Query: 251  TC 252
             C
Sbjct: 1816 HC 1817



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%)

Query: 257  ECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSSYLCQY-QCVN 311
            EC   N C   +C  +   + C C +G++L +  + C D++EC      + LC +  C N
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795

Query: 312  EPGKFSCMCPQGY 324
              G + C C  GY
Sbjct: 1796 TEGSYRCHCSPGY 1808



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 6/71 (8%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTP-ENRCV 378
           CPQGY+ +    CQDINEC T   C++ E C N  G + C     C+   +L P  +RCV
Sbjct: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRSRCV 662

Query: 379 CPVSNAMCREL 389
              + +M + L
Sbjct: 663 SDKAISMLQGL 673



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 7/65 (10%)

Query: 143 PADPQRIPSNP---SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC 199
           P  P+  P++P   + +++C  GY++     CQDI+EC   T     D  C+N RGS+ C
Sbjct: 591 PCPPR--PASPVIENGQLECPQGYKRLNLTHCQDINECL--TLGLCKDAECVNTRGSYLC 646

Query: 200 QCPPG 204
            C PG
Sbjct: 647 TCRPG 651



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 7/57 (12%)

Query: 278 QCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
           +C QGY+    RLN   C+DI+EC T       +CVN  G + C C  G  +  SR+
Sbjct: 607 ECPQGYK----RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 10/80 (12%)

Query: 296  DECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINECETTNE----CREDEMC 350
            +EC   +     +CV     ++C C +G+Q+  +   C D+NEC+  N     C     C
Sbjct: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG-YC 1793

Query: 351  WNYHGGFRCYPRNPCQDPYI 370
             N  G +RC+    C   Y+
Sbjct: 1794 ENTEGSYRCH----CSPGYV 1809



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 3/43 (6%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC 70
           +C  GY+   +   C+DI+EC +    CK   +CVN  G YLC
Sbjct: 607 ECPQGYKRLNLTH-CQDINEC-LTLGLCKDA-ECVNTRGSYLC 646



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 4/45 (8%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLC 70
            C +G++ D     C D++ECD +      C  G  C N  G Y C
Sbjct: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYRC 1802


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  167 bits (422), Expect = 3e-41
 Identities = 122/345 (35%), Positives = 163/345 (47%), Gaps = 31/345 (8%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY     R +C+DIDEC + P  C    +CVN  G Y C+P T      N Q     
Sbjct: 985  CDSGYRMTQ-RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVD 1041

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASA--AAVAGPEMQTGRNNFVIRRNP--A 144
            +  E         V A+   ++     G ++ S        P+ +  R+    ++     
Sbjct: 1042 ECLEPN-------VCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 1091

Query: 145  DPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
            + Q   +  S R  C  GY+ S   + C+DIDEC    H C   Q C N  GSF C C  
Sbjct: 1092 NGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQ 1149

Query: 204  GYQKRG--EQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECD 259
            GY+  G  + C DI+EC       QR  C+NT GS+ C C  GFQL  +N TC DINEC+
Sbjct: 1150 GYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE 1208

Query: 260  ASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQ--CVNEPGK 315
                C  Q  C N  GSF C C QG+ +S+D   CEDIDEC  ++ +C     C N  G 
Sbjct: 1209 HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 1267

Query: 316  FSCMCPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
            F C+C QG+Q  +  + C D+NECE  +    +  C N  G F C
Sbjct: 1268 FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 1312



 Score =  163 bits (412), Expect = 4e-40
 Identities = 123/421 (29%), Positives = 181/421 (42%), Gaps = 56/421 (13%)

Query: 41   QCKDIDECDIVPDACKGGMKCVNH--------YGGYLCLPKTAQIIVNNEQPQQETQPAE 92
            Q  +I+EC + PD C  G  C+N         Y GY    +  + +  +E  Q +   ++
Sbjct: 871  QVTEINECTVNPDICGAG-HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 929

Query: 93   GTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSN 152
            G    T G       A        GF+AS       ++       V      +   + + 
Sbjct: 930  GRCENTEGSFLCICPA--------GFMASEEGTNCIDVDECLRPDVC----GEGHCVNTV 977

Query: 153  PSHRIQ-CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE 210
             + R + C +GY  ++   C+DIDEC      C  D+ C+N  GS+ C  C  G++    
Sbjct: 978  GAFRCEYCDSGYRMTQRGRCEDIDECL-NPSTC-PDEQCVNSPGSYQCVPCTEGFRGWNG 1035

Query: 211  QCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QC 268
            QC+D+DEC  P  C +  C N  GS+ C C  G+    ++  C DI+EC   N C   QC
Sbjct: 1036 QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC 1095

Query: 269  YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV- 327
             N  GSF C C QGY+LS+ +  CEDIDEC+        QC N  G F C+C QGY+   
Sbjct: 1096 KNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG 1155

Query: 328  RSRTCQDINEC-ETTNECREDEMCWNYHGGF--------------RCYPRNPCQDPYILT 372
                C+DINEC E  + C+  + C N  G +               C   N C+ P +  
Sbjct: 1156 LGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCG 1214

Query: 373  PENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTI------YANTINTF 426
            P+  C+    +  C      +  +  SI +D     DI +    T+        NT  +F
Sbjct: 1215 PQGECLNTEGSFHC------VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 1268

Query: 427  R 427
            R
Sbjct: 1269 R 1269



 Score =  144 bits (363), Expect = 2e-34
 Identities = 111/384 (28%), Positives = 166/384 (43%), Gaps = 47/384 (12%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGM----------KCVNHY---GGYLCLPKTA 75
            C+ G  W P  ++C  +       + C GGM          + ++H+   G     PK  
Sbjct: 704  CSVGKAWGPHCEKCP-LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNT 762

Query: 76   QIIVNNEQPQQETQPAEGTSGATTGV-----VAASSMATSGV---LPGGGFVASAAAVAG 127
            Q +  +  P       E     T        VA   +AT+     +P      +      
Sbjct: 763  QPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQ 822

Query: 128  PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQ--------DIDECTA 179
            P++  G +   I  +P  P  +    S  +      E S  +  Q        +I+ECT 
Sbjct: 823  PQLSPGIST--IHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTV 880

Query: 180  GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDECT-IPPYCHQ-RCVNTPGSF 235
                C A   CINL   + C C  GY+  ++  +CVDIDECT +   C Q RC NT GSF
Sbjct: 881  NPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSF 939

Query: 236  YCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQ-CNQGYELSSDRLNCE 293
             C C  GF  +     C+D++EC   + C +  C N +G+F C+ C+ GY + + R  CE
Sbjct: 940  LCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCE 998

Query: 294  DIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECREDEMCWN 352
            DIDEC   S     QCVN PG + C+ C +G++    + C D++EC   N C   + C N
Sbjct: 999  DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ-CLDVDECLEPNVCANGD-CSN 1056

Query: 353  YHGGFRCYPRNPCQDPYILTPENR 376
              G + C     C   Y  TP+++
Sbjct: 1057 LEGSYMC----SCHKGYTRTPDHK 1076



 Score =  106 bits (264), Expect = 6e-23
 Identities = 82/295 (27%), Positives = 118/295 (40%), Gaps = 23/295 (7%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY   P  + C+DIDEC    + C  G +C N  G + C       +   +   ++ 
Sbjct: 1065 CHKGYTRTPDHKHCRDIDECQ-QGNLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDI 1122

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
               +       G    +  +   V   G   +          +   +  V +R       
Sbjct: 1123 DECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC---- 1178

Query: 149  IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
            I +  S+   C  G++  ++  CQDI+EC      C     C+N  GSF C C  G+   
Sbjct: 1179 INTAGSYDCTCPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSIS 1237

Query: 207  KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQ 263
              G  C DIDEC     C  H  C NT GSF C C  GFQ   +   CVD+NEC+  S  
Sbjct: 1238 ADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGV 1297

Query: 264  CAQQ-CYNILGSFICQC---NQGYELSSDRLNCE-------DIDECRTSSYLCQY 307
            C +  C N+ GSF+C C   NQ Y   + +           D+D+ +     C Y
Sbjct: 1298 CGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1352



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 114/460 (24%), Positives = 176/460 (38%), Gaps = 101/460 (21%)

Query: 18   QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQ 76
            ++TE +   T C  GY+    + QC+DIDEC      C  G +C N  G + C+  +  +
Sbjct: 1096 KNTEGSFRCT-CGQGYQLSAAKDQCEDIDECQ-HRHLCAHG-QCRNTEGSFQCVCDQGYR 1152

Query: 77   IIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
                 +  +   +  E  S    G    ++ +     P G              Q   N 
Sbjct: 1153 ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG-------------FQLDDNK 1199

Query: 137  FVIRRNPAD------PQR--IPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRAD 187
                 N  +      PQ   + +  S    C  G+   ++   C+DIDEC   T  C + 
Sbjct: 1200 TCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSH 1258

Query: 188  QVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPPYCHQR-CVNTPGSFYCQCSP-- 241
              C N  GSF C C  G+Q  + G+ CVD++EC  +   C +  C N  GSF C C+   
Sbjct: 1259 GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 1318

Query: 242  ------GFQLAANNYTCVDIN---------ECDASNQCAQQCYNILGSFI----CQCNQG 282
                    Q  +   T +D++         EC  +   A  C N+L   +    C C  G
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1378

Query: 283  Y---------------------------------ELSSDR--LNCEDIDECRT-SSYLCQ 306
                                              E SS+    N +D DEC      +C+
Sbjct: 1379 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1438

Query: 307  YQ-CVNEPGKFSCMCPQG--YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRN 363
               C+N    + C C QG  Y  V+ + C D++EC+  + C  D  C N  G + C+   
Sbjct: 1439 NGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQDPSSC-IDGQCVNTEGSYNCF--- 1493

Query: 364  PCQDPYIL-TPENRCVCPV-SNAMCRE--LPQSIVYKYMS 399
             C  P +L   E RC+ P  SN    E  + Q + ++++S
Sbjct: 1494 -CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLS 1532



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 61/270 (22%), Positives = 97/270 (35%), Gaps = 54/270 (20%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ----P 84
            C  G  +DPV+ QC D+DEC   P +C  G +CVN  G Y C      ++  +E+    P
Sbjct: 1453 CKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRP 1510

Query: 85   QQETQPAEGTSG--------------ATTGVVAASSMATSGVLPGGGFVASAAA------ 124
             +  +  E T                 +  +V   +  T      G       A      
Sbjct: 1511 AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD 1570

Query: 125  -----------VAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQD 173
                       V G     GR+  V       P+  P     R      +E+ +   C  
Sbjct: 1571 SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF--LNSFEELQAEECGI 1628

Query: 174  IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECT-----IPPYCHQ 226
            ++ C  G         C+ ++  + C C  GY     +  CVD++EC      +    + 
Sbjct: 1629 LNGCENGR--------CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1680

Query: 227  RCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
            +C+NT GS+ C C PG+  +     C  +N
Sbjct: 1681 KCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 32/82 (39%), Positives = 40/82 (48%), Gaps = 7/82 (8%)

Query: 216  DECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ----CAQ-QCY 269
            +EC I   C   RCV     + C C  G+ L     TCVD+NECD  N     C   +C 
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1683

Query: 270  NILGSFICQCNQGYELSSDRLN 291
            N  GS+ C C  GY + SD+ N
Sbjct: 1684 NTDGSYKCLCLPGY-VPSDKPN 1704



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 7/94 (7%)

Query: 195 GSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPG----SFYCQCSPGFQLAANNY 250
           GS   +  PG  K+ + C  +        C Q+C   P     +   +C PG++   NN 
Sbjct: 565 GSQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVNNT 622

Query: 251 TCVDINECDASNQCAQ-QCYNILGSFICQCNQGY 283
            C DINEC     C   +C N +GS+ C C  G+
Sbjct: 623 FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 147 QRIPSNPSHR-----IQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
           Q+ P  PS+      ++C  GY++  +  CQDI+EC         +  C+N  GS+ C C
Sbjct: 595 QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTC 652

Query: 202 PPGY 205
             G+
Sbjct: 653 KIGF 656



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 2/56 (3%)

Query: 200 QCPPGYQKRGEQ-CVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
           +C PGY++     C DI+EC +   C +  C+NT GS+ C C  GF       +CV
Sbjct: 611 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 666



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 1/40 (2%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           C  GY+ V +  CQDINEC+    C   E C N  G +RC
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQGVCPNGE-CLNTMGSYRC 650



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 14/47 (29%), Positives = 25/47 (53%), Gaps = 1/47 (2%)

Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
           +C  GY+  ++   C+DI+EC+        +C+N  G + C C  G+
Sbjct: 611 ECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 656


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  167 bits (422), Expect = 3e-41
 Identities = 122/345 (35%), Positives = 163/345 (47%), Gaps = 31/345 (8%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  GY     R +C+DIDEC + P  C    +CVN  G Y C+P T      N Q     
Sbjct: 659 CDSGYRMTQ-RGRCEDIDEC-LNPSTCPDE-QCVNSPGSYQCVPCTEGFRGWNGQCLDVD 715

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASA--AAVAGPEMQTGRNNFVIRRNP--A 144
           +  E         V A+   ++     G ++ S        P+ +  R+    ++     
Sbjct: 716 ECLEPN-------VCANGDCSN---LEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCV 765

Query: 145 DPQRIPSNPSHRIQCAAGYEQSE-HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
           + Q   +  S R  C  GY+ S   + C+DIDEC    H C   Q C N  GSF C C  
Sbjct: 766 NGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQH-RHLCAHGQ-CRNTEGSFQCVCDQ 823

Query: 204 GYQKRG--EQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINECD 259
           GY+  G  + C DI+EC       QR  C+NT GS+ C C  GFQL  +N TC DINEC+
Sbjct: 824 GYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECE 882

Query: 260 ASNQCAQQ--CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQ--CVNEPGK 315
               C  Q  C N  GSF C C QG+ +S+D   CEDIDEC  ++ +C     C N  G 
Sbjct: 883 HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGS 941

Query: 316 FSCMCPQGYQVVRS-RTCQDINECETTNECREDEMCWNYHGGFRC 359
           F C+C QG+Q  +  + C D+NECE  +    +  C N  G F C
Sbjct: 942 FRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC 986



 Score =  163 bits (412), Expect = 4e-40
 Identities = 123/421 (29%), Positives = 181/421 (42%), Gaps = 56/421 (13%)

Query: 41  QCKDIDECDIVPDACKGGMKCVNH--------YGGYLCLPKTAQIIVNNEQPQQETQPAE 92
           Q  +I+EC + PD C  G  C+N         Y GY    +  + +  +E  Q +   ++
Sbjct: 545 QVTEINECTVNPDICGAG-HCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQ 603

Query: 93  GTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSN 152
           G    T G       A        GF+AS       ++       V      +   + + 
Sbjct: 604 GRCENTEGSFLCICPA--------GFMASEEGTNCIDVDECLRPDVC----GEGHCVNTV 651

Query: 153 PSHRIQ-CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE 210
            + R + C +GY  ++   C+DIDEC      C  D+ C+N  GS+ C  C  G++    
Sbjct: 652 GAFRCEYCDSGYRMTQRGRCEDIDECL-NPSTC-PDEQCVNSPGSYQCVPCTEGFRGWNG 709

Query: 211 QCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QC 268
           QC+D+DEC  P  C +  C N  GS+ C C  G+    ++  C DI+EC   N C   QC
Sbjct: 710 QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQC 769

Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV- 327
            N  GSF C C QGY+LS+ +  CEDIDEC+        QC N  G F C+C QGY+   
Sbjct: 770 KNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG 829

Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGF--------------RCYPRNPCQDPYILT 372
               C+DINEC E  + C+  + C N  G +               C   N C+ P +  
Sbjct: 830 LGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCG 888

Query: 373 PENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTI------YANTINTF 426
           P+  C+    +  C      +  +  SI +D     DI +    T+        NT  +F
Sbjct: 889 PQGECLNTEGSFHC------VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSF 942

Query: 427 R 427
           R
Sbjct: 943 R 943



 Score =  144 bits (363), Expect = 2e-34
 Identities = 111/384 (28%), Positives = 166/384 (43%), Gaps = 47/384 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGM----------KCVNHY---GGYLCLPKTA 75
           C+ G  W P  ++C  +       + C GGM          + ++H+   G     PK  
Sbjct: 378 CSVGKAWGPHCEKCP-LPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNT 436

Query: 76  QIIVNNEQPQQETQPAEGTSGATTGV-----VAASSMATSGV---LPGGGFVASAAAVAG 127
           Q +  +  P       E     T        VA   +AT+     +P      +      
Sbjct: 437 QPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQ 496

Query: 128 PEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQ--------DIDECTA 179
           P++  G +   I  +P  P  +    S  +      E S  +  Q        +I+ECT 
Sbjct: 497 PQLSPGIST--IHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTV 554

Query: 180 GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDECT-IPPYCHQ-RCVNTPGSF 235
               C A   CINL   + C C  GY+  ++  +CVDIDECT +   C Q RC NT GSF
Sbjct: 555 NPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSF 613

Query: 236 YCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQ-CNQGYELSSDRLNCE 293
            C C  GF  +     C+D++EC   + C +  C N +G+F C+ C+ GY + + R  CE
Sbjct: 614 LCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM-TQRGRCE 672

Query: 294 DIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTNECREDEMCWN 352
           DIDEC   S     QCVN PG + C+ C +G++    + C D++EC   N C   + C N
Sbjct: 673 DIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ-CLDVDECLEPNVCANGD-CSN 730

Query: 353 YHGGFRCYPRNPCQDPYILTPENR 376
             G + C     C   Y  TP+++
Sbjct: 731 LEGSYMC----SCHKGYTRTPDHK 750



 Score =  106 bits (264), Expect = 6e-23
 Identities = 82/295 (27%), Positives = 118/295 (40%), Gaps = 23/295 (7%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  GY   P  + C+DIDEC    + C  G +C N  G + C       +   +   ++ 
Sbjct: 739  CHKGYTRTPDHKHCRDIDECQ-QGNLCVNG-QCKNTEGSFRCTCGQGYQLSAAKDQCEDI 796

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
               +       G    +  +   V   G   +          +   +  V +R       
Sbjct: 797  DECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDC---- 852

Query: 149  IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-- 206
            I +  S+   C  G++  ++  CQDI+EC      C     C+N  GSF C C  G+   
Sbjct: 853  INTAGSYDCTCPDGFQLDDNKTCQDINECEH-PGLCGPQGECLNTEGSFHCVCQQGFSIS 911

Query: 207  KRGEQCVDIDECTIPPYC--HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECD-ASNQ 263
              G  C DIDEC     C  H  C NT GSF C C  GFQ   +   CVD+NEC+  S  
Sbjct: 912  ADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGV 971

Query: 264  CAQQ-CYNILGSFICQC---NQGYELSSDRLNCE-------DIDECRTSSYLCQY 307
            C +  C N+ GSF+C C   NQ Y   + +           D+D+ +     C Y
Sbjct: 972  CGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1026



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 114/460 (24%), Positives = 176/460 (38%), Gaps = 101/460 (21%)

Query: 18   QDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQ 76
            ++TE +   T C  GY+    + QC+DIDEC      C  G +C N  G + C+  +  +
Sbjct: 770  KNTEGSFRCT-CGQGYQLSAAKDQCEDIDECQ-HRHLCAHG-QCRNTEGSFQCVCDQGYR 826

Query: 77   IIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
                 +  +   +  E  S    G    ++ +     P G              Q   N 
Sbjct: 827  ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG-------------FQLDDNK 873

Query: 137  FVIRRNPAD------PQR--IPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRAD 187
                 N  +      PQ   + +  S    C  G+   ++   C+DIDEC   T  C + 
Sbjct: 874  TCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT-VCDSH 932

Query: 188  QVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPPYCHQR-CVNTPGSFYCQCSP-- 241
              C N  GSF C C  G+Q  + G+ CVD++EC  +   C +  C N  GSF C C+   
Sbjct: 933  GFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADEN 992

Query: 242  ------GFQLAANNYTCVDIN---------ECDASNQCAQQCYNILGSFI----CQCNQG 282
                    Q  +   T +D++         EC  +   A  C N+L   +    C C  G
Sbjct: 993  QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1052

Query: 283  Y---------------------------------ELSSDR--LNCEDIDECRT-SSYLCQ 306
                                              E SS+    N +D DEC      +C+
Sbjct: 1053 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1112

Query: 307  YQ-CVNEPGKFSCMCPQG--YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRN 363
               C+N    + C C QG  Y  V+ + C D++EC+  + C  D  C N  G + C+   
Sbjct: 1113 NGFCLNTRPGYECYCKQGTYYDPVKLQ-CFDMDECQDPSSC-IDGQCVNTEGSYNCF--- 1167

Query: 364  PCQDPYIL-TPENRCVCPV-SNAMCRE--LPQSIVYKYMS 399
             C  P +L   E RC+ P  SN    E  + Q + ++++S
Sbjct: 1168 -CTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLS 1206



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 61/270 (22%), Positives = 97/270 (35%), Gaps = 54/270 (20%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQ----P 84
            C  G  +DPV+ QC D+DEC   P +C  G +CVN  G Y C      ++  +E+    P
Sbjct: 1127 CKQGTYYDPVKLQCFDMDECQD-PSSCIDG-QCVNTEGSYNCFCTHPMVLDASEKRCIRP 1184

Query: 85   QQETQPAEGTSG--------------ATTGVVAASSMATSGVLPGGGFVASAAA------ 124
             +  +  E T                 +  +V   +  T      G       A      
Sbjct: 1185 AESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD 1244

Query: 125  -----------VAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQD 173
                       V G     GR+  V       P+  P     R      +E+ +   C  
Sbjct: 1245 SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF--LNSFEELQAEECGI 1302

Query: 174  IDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECT-----IPPYCHQ 226
            ++ C  G         C+ ++  + C C  GY     +  CVD++EC      +    + 
Sbjct: 1303 LNGCENGR--------CVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1354

Query: 227  RCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
            +C+NT GS+ C C PG+  +     C  +N
Sbjct: 1355 KCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 32/82 (39%), Positives = 40/82 (48%), Gaps = 7/82 (8%)

Query: 216  DECTIPPYCHQ-RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ----CAQ-QCY 269
            +EC I   C   RCV     + C C  G+ L     TCVD+NECD  N     C   +C 
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCI 1357

Query: 270  NILGSFICQCNQGYELSSDRLN 291
            N  GS+ C C  GY + SD+ N
Sbjct: 1358 NTDGSYKCLCLPGY-VPSDKPN 1378



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 7/94 (7%)

Query: 195 GSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPG----SFYCQCSPGFQLAANNY 250
           GS   +  PG  K+ + C  +        C Q+C   P     +   +C PG++   NN 
Sbjct: 239 GSQCGKALPGLSKQEDCCGTVGTSWGFNKC-QKCPKKPSYHGYNQMMECLPGYK-RVNNT 296

Query: 251 TCVDINECDASNQCAQ-QCYNILGSFICQCNQGY 283
            C DINEC     C   +C N +GS+ C C  G+
Sbjct: 297 FCQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 7/64 (10%)

Query: 147 QRIPSNPSHR-----IQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
           Q+ P  PS+      ++C  GY++  +  CQDI+EC         +  C+N  GS+ C C
Sbjct: 269 QKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQ--LQGVCPNGECLNTMGSYRCTC 326

Query: 202 PPGY 205
             G+
Sbjct: 327 KIGF 330



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 21/56 (37%), Positives = 30/56 (53%), Gaps = 2/56 (3%)

Query: 200 QCPPGYQKRGEQ-CVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
           +C PGY++     C DI+EC +   C +  C+NT GS+ C C  GF       +CV
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCV 340



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 18/40 (45%), Positives = 22/40 (55%), Gaps = 1/40 (2%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           C  GY+ V +  CQDINEC+    C   E C N  G +RC
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQGVCPNGE-CLNTMGSYRC 324



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 14/47 (29%), Positives = 25/47 (53%), Gaps = 1/47 (2%)

Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
           +C  GY+  ++   C+DI+EC+        +C+N  G + C C  G+
Sbjct: 285 ECLPGYKRVNNTF-CQDINECQLQGVCPNGECLNTMGSYRCTCKIGF 330


>gi|194328809 latent transforming growth factor beta binding protein
           3 isoform 1 [Homo sapiens]
          Length = 1303

 Score =  166 bits (420), Expect = 4e-41
 Identities = 113/339 (33%), Positives = 154/339 (45%), Gaps = 55/339 (16%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  GY   P  + C D++EC+  P     G+ C+N  G Y C               +  
Sbjct: 601 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGI-CMNTGGSYNC------------HCNRGY 647

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
           +   G  G +   V  +  A   +   GGF                 NF           
Sbjct: 648 RLHVGAGGRSC--VDLNECAKPHLCGDGGFCI---------------NF----------- 679

Query: 149 IPSNPSH-RIQCAAGY--EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPG 204
               P H +  C  GY  + S   VC+DIDEC   + +C  D  C N  GSF C  C PG
Sbjct: 680 ----PGHYKCNCYPGYRLKASRPPVCEDIDECRDPS-SC-PDGKCENKPGSFKCIACQPG 733

Query: 205 YQKRGE-QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
           Y+ +G   C D++EC     C    C N PGSF C C+ G+  A +  +C+D++EC+A +
Sbjct: 734 YRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793

Query: 263 QCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
            C    C N  GSF CQC  GY LS DR +CEDIDEC   +      C+N  G + C+CP
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853

Query: 322 QGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
           QG+++V  R CQDI+EC +  + C     C N  G + C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892



 Score =  141 bits (355), Expect = 2e-33
 Identities = 86/263 (32%), Positives = 118/263 (44%), Gaps = 55/263 (20%)

Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQ-VCINLRGSFACQCPPGYQ 206
           +P  P +   C  GY    +H  C D++EC A    C   + +C+N  GS+ C C  GY+
Sbjct: 591 VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGICMNTGGSYNCHCNRGYR 648

Query: 207 KR----GEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANN-YTCVDINEC- 258
                 G  CVD++EC  P  C     C+N PG + C C PG++L A+    C DI+EC 
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708

Query: 259 DAS----------------------------------NQCAQ-------QCYNILGSFIC 277
           D S                                  N+CA+        C N+ GSF C
Sbjct: 709 DPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRC 768

Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT-CQDIN 336
            C QGY  + D  +C D+DEC          C N PG F C C  GY + R R+ C+DI+
Sbjct: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828

Query: 337 ECETTNECREDEMCWNYHGGFRC 359
           EC+    C   + C N +G +RC
Sbjct: 829 ECDFPAACIGGD-CINTNGSYRC 850



 Score =  140 bits (352), Expect = 3e-33
 Identities = 93/277 (33%), Positives = 127/277 (45%), Gaps = 30/277 (10%)

Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQR--C 228
           + DEC    + C   + C+     ++C C PGY+   +   CVD++EC   P    R  C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632

Query: 229 VNTPGSFYCQCSPGFQL--AANNYTCVDINECDASNQCAQQ--CYNILGSFICQCNQGYE 284
           +NT GS+ C C+ G++L   A   +CVD+NEC   + C     C N  G + C C  GY 
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692

Query: 285 LSSDRLN-CEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTN 342
           L + R   CEDIDECR  S     +C N+PG F C+ C  GY+      C+D+NEC   +
Sbjct: 693 LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752

Query: 343 ECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPV---------SNAMCRELPQSI 393
            C     C N  G FRC     C   Y   P+ R    V          N +C   P S 
Sbjct: 753 PC-SPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807

Query: 394 VYKYMS---IRSDRSVPSDIFQ--IQATTIYANTINT 425
             + +S   +  DRS   DI +    A  I  + INT
Sbjct: 808 QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844



 Score =  109 bits (273), Expect = 5e-24
 Identities = 111/421 (26%), Positives = 163/421 (38%), Gaps = 78/421 (18%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVNNEQ---------- 83
           C+DI+EC  +P  C+ G  C+N+ G Y C+        P   Q I +  +          
Sbjct: 353 CQDINEC-AMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410

Query: 84  PQQETQPAEGTS--------------GA------TTGVVAASSMATSGVLPGGGFVASAA 123
           P+ + Q    T               GA      T G  A   +  +G    G  + ++ 
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK---GYHILTSH 467

Query: 124 AVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDE------- 176
                + ++  + F+    P  PQ++P +PS         E+        + E       
Sbjct: 468 QTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQS 527

Query: 177 -CTAGTHNCRADQVCINLRGS-----FACQCPPG---YQKRGEQCVDIDECTIPPYC--H 225
             TA T   R     I+         F    PP     +    Q  + DEC +      H
Sbjct: 528 HPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGH 587

Query: 226 QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSFICQCNQG 282
             CV  P  + C C+PG++    +  CVD+NEC+A   C      C N  GS+ C CN+G
Sbjct: 588 GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRG 646

Query: 283 YEL--SSDRLNCEDIDECRTSSYLCQYQ--CVNEPGKFSCMCPQGYQVVRSR--TCQDIN 336
           Y L   +   +C D++EC    +LC     C+N PG + C C  GY++  SR   C+DI+
Sbjct: 647 YRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705

Query: 337 ECETTNECREDEMCWNYHGGFRCYPRNP---CQDPYILTPENRCV--CPVSNAMCRELPQ 391
           EC   + C  D  C N  G F+C    P    Q        N C    P S   C  LP 
Sbjct: 706 ECRDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG 764

Query: 392 S 392
           S
Sbjct: 765 S 765



 Score =  107 bits (267), Expect = 2e-23
 Identities = 95/357 (26%), Positives = 134/357 (37%), Gaps = 52/357 (14%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            QC  GY     R  C+DIDECD  P AC GG  C+N  G Y CL      +V   + Q  
Sbjct: 810  QCLSGYHLSRDRSHCEDIDECDF-PAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQD- 866

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                          +   S   S  LP G    +   + G  +      F   ++    +
Sbjct: 867  --------------IDECSQDPSLCLPHG----ACKNLQGSYVCVCDEGFTPTQDQHGCE 908

Query: 148  RIPSNPSHRIQCAAGYEQSEH-------NVCQDIDECTAGT---HNCRADQVCINLRGSF 197
             +   P H+ +C   ++ +         NV Q    C+ G     +C      +     F
Sbjct: 909  EV-EQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967

Query: 198  ACQCPPGYQKRGEQCV---------DIDECTI--PPYCHQ-RCVNTPGSFYCQCSPGFQL 245
               CP G     +  +         DIDEC +     C + +CVNT   + C C  GF  
Sbjct: 968  HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY 1027

Query: 246  AANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSDRLNC-----EDIDECR 299
              N   CVD++EC D SN     C N  G + C C    E S  +  C      D+DEC+
Sbjct: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ 1087

Query: 300  TSSYLCQYQCVNEPGKFSCMC-PQGYQVVRSRTCQDINECETTNECREDEMCWNYHG 355
              +     +CVN PG + C C P        R CQ + E          ++CW+  G
Sbjct: 1088 DPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ-LPESPAERAPERRDVCWSQRG 1143



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 79/292 (27%), Positives = 110/292 (37%), Gaps = 61/292 (20%)

Query: 149  IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
            I +N S+R  C  G+       CQDIDEC+     C     C NL+GS+ C C  G+   
Sbjct: 842  INTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPT 901

Query: 209  GEQ--CVDID------ECTI----PPYC---------HQRC------------------V 229
             +Q  C +++      EC +      +C          Q C                  V
Sbjct: 902  QDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPV 961

Query: 230  NTPGSFYCQCSPGFQLAANNYTC-------VDINEC--DASNQCAQ-QCYNILGSFICQC 279
             +   F+  C  G     +N           DI+EC    S  C + +C N    + C C
Sbjct: 962  YSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYC 1021

Query: 280  NQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC-PQGYQVVRSRTC-----Q 333
             QG+    + L C D+DEC   S      C N  G + C C P        R C      
Sbjct: 1022 KQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEM 1081

Query: 334  DINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CVCPVSNA 384
            D++EC+    CR    C N  G +RC     C+ P++  P  R C  P S A
Sbjct: 1082 DVDECQDPAACRPGR-CVNLPGSYRC----ECRPPWVPGPSGRDCQLPESPA 1128



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 81/282 (28%), Positives = 107/282 (37%), Gaps = 64/282 (22%)

Query: 29   CTDGYEWDPVRQQC-----KDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQII-VNNE 82
            CT   E+ P ++QC      D+DEC   P AC+ G +CVN  G Y C  +   +   +  
Sbjct: 1062 CTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPG-RCVNLPGSYRCECRPPWVPGPSGR 1119

Query: 83   QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-------QTGRN 135
              Q    PAE         V  S     G+  G         +AGP +       + GR 
Sbjct: 1120 DCQLPESPAERAPERRD--VCWSQRGEDGMCAG--------PLAGPALTFDDCCCRQGRG 1169

Query: 136  NFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRG 195
             +  +  P  P+   S+      C     QSE N   D      G               
Sbjct: 1170 -WGAQCRPCPPRGAGSH------CPTS--QSESNSFWDTSPLLLGK-------------- 1206

Query: 196  SFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI 255
                  PP  +   E+  D DEC        RCV  PG   C+C  GFQL A+   CVDI
Sbjct: 1207 ------PPRDEDSSEE--DSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDI 1255

Query: 256  NECDASNQ----C-AQQCYNILGSFICQCNQGYELSSDRLNC 292
            +EC   NQ    C +++C N  GSF C C  G+  S     C
Sbjct: 1256 DECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 82/346 (23%), Positives = 121/346 (34%), Gaps = 103/346 (29%)

Query: 43   KDIDECDIV-PDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGV 101
            +DIDEC +   + CK G KCVN   GY C  K       N     +       S    GV
Sbjct: 992  RDIDECMLFGSEICKEG-KCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGV 1050

Query: 102  VAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAA 161
               +          GG+  +                     PA+      +P+ R QC +
Sbjct: 1051 CENTR---------GGYRCACTP------------------PAE-----YSPAQR-QCLS 1077

Query: 162  GYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY---------------- 205
              E+ + + CQD   C  G         C+NL GS+ C+C P +                
Sbjct: 1078 P-EEMDVDECQDPAACRPGR--------CVNLPGSYRCECRPPWVPGPSGRDCQLPESPA 1128

Query: 206  -----------QKRGEQCVDIDECTIPPYCHQRCVNTPGSFY-CQCSPGFQLAANNYTCV 253
                        +RGE  +       P      C    G  +  QC P     A ++   
Sbjct: 1129 ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPT 1188

Query: 254  DINECDA----------------------SNQC---AQQCYNILGSFICQCNQGYELSSD 288
              +E ++                      S++C   + +C    G  +C+C  G++L + 
Sbjct: 1189 SQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDAS 1248

Query: 289  RLNCEDIDECR---TSSYLCQYQ-CVNEPGKFSCMCPQGYQVVRSR 330
            R  C DIDECR       LC+ + CVN  G F C+C  G+   RSR
Sbjct: 1249 RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF--ARSR 1292



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 193 LRGSFACQCPPGYQK-RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNY 250
           +RG     CP GY++     C DI+EC +P  C H  C+N PGS+ C C PG  L  +  
Sbjct: 333 VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 251 TCVDINECDAS---------NQCAQQCYNILGSFICQCNQG 282
            C+     + S         +QC       L   +C C+ G
Sbjct: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 31/142 (21%)

Query: 271 ILGSFICQCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
           + G     C QGY+    RLN   C+DI+EC          C+N PG + C+CP G+ + 
Sbjct: 333 VRGEVGADCPQGYK----RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388

Query: 328 RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCR 387
            SRT     +C   ++  E  +C+                  +++PE++C  P++  + R
Sbjct: 389 PSRT-----QC-IADKPEEKSLCFR-----------------LVSPEHQCQHPLTTRLTR 425

Query: 388 ELPQSIVYKYMSIRSDRSVPSD 409
           +L    V K    R  R  P+D
Sbjct: 426 QLCCCSVGKAWGARCQR-CPTD 446



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 27/168 (16%)

Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRC-------VNTPGSFY----CQCSPGFQLAANNYT 251
           PG  K+ + C  I        CH +C       V  PG         C  G++   N+  
Sbjct: 295 PGLTKQEDCCGSIGTAWGQSKCH-KCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTH 352

Query: 252 CVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC-----EDIDEC---RTSS 302
           C DINEC     C    C N  GS+ C C  G+ L   R  C     E+   C    +  
Sbjct: 353 CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPE 412

Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
           + CQ+       +  C C  G        CQ    C T       E+C
Sbjct: 413 HQCQHPLTTRLTRQLCCCSVG--KAWGARCQ---RCPTDGTAAFKEIC 455



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           C  GY++     CQDI+EC A    CR    C+N  GS+ C CPPG+
Sbjct: 341 CPQGYKRLNSTHCQDINEC-AMPGVCRHGD-CLNNPGSYRCVCPPGH 385



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLCLPK 73
            +C  G++ D  R +C DIDEC  +      CK   +CVN  G + C+ K
Sbjct: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGSFRCVCK 1285


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score =  166 bits (420), Expect = 4e-41
 Identities = 113/339 (33%), Positives = 154/339 (45%), Gaps = 55/339 (16%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C  GY   P  + C D++EC+  P     G+ C+N  G Y C               +  
Sbjct: 601 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGI-CMNTGGSYNC------------HCNRGY 647

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
           +   G  G +   V  +  A   +   GGF                 NF           
Sbjct: 648 RLHVGAGGRSC--VDLNECAKPHLCGDGGFCI---------------NF----------- 679

Query: 149 IPSNPSH-RIQCAAGY--EQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFAC-QCPPG 204
               P H +  C  GY  + S   VC+DIDEC   + +C  D  C N  GSF C  C PG
Sbjct: 680 ----PGHYKCNCYPGYRLKASRPPVCEDIDECRDPS-SC-PDGKCENKPGSFKCIACQPG 733

Query: 205 YQKRGE-QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
           Y+ +G   C D++EC     C    C N PGSF C C+ G+  A +  +C+D++EC+A +
Sbjct: 734 YRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793

Query: 263 QCAQQ-CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
            C    C N  GSF CQC  GY LS DR +CEDIDEC   +      C+N  G + C+CP
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853

Query: 322 QGYQVVRSRTCQDINEC-ETTNECREDEMCWNYHGGFRC 359
           QG+++V  R CQDI+EC +  + C     C N  G + C
Sbjct: 854 QGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVC 892



 Score =  141 bits (355), Expect = 2e-33
 Identities = 86/263 (32%), Positives = 118/263 (44%), Gaps = 55/263 (20%)

Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQ-VCINLRGSFACQCPPGYQ 206
           +P  P +   C  GY    +H  C D++EC A    C   + +C+N  GS+ C C  GY+
Sbjct: 591 VPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPGRGICMNTGGSYNCHCNRGYR 648

Query: 207 KR----GEQCVDIDECTIPPYCHQR--CVNTPGSFYCQCSPGFQLAANN-YTCVDINEC- 258
                 G  CVD++EC  P  C     C+N PG + C C PG++L A+    C DI+EC 
Sbjct: 649 LHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR 708

Query: 259 DAS----------------------------------NQCAQ-------QCYNILGSFIC 277
           D S                                  N+CA+        C N+ GSF C
Sbjct: 709 DPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRC 768

Query: 278 QCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT-CQDIN 336
            C QGY  + D  +C D+DEC          C N PG F C C  GY + R R+ C+DI+
Sbjct: 769 TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDID 828

Query: 337 ECETTNECREDEMCWNYHGGFRC 359
           EC+    C   + C N +G +RC
Sbjct: 829 ECDFPAACIGGD-CINTNGSYRC 850



 Score =  140 bits (352), Expect = 3e-33
 Identities = 93/277 (33%), Positives = 127/277 (45%), Gaps = 30/277 (10%)

Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQR--C 228
           + DEC    + C   + C+     ++C C PGY+   +   CVD++EC   P    R  C
Sbjct: 574 ETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632

Query: 229 VNTPGSFYCQCSPGFQL--AANNYTCVDINECDASNQCAQQ--CYNILGSFICQCNQGYE 284
           +NT GS+ C C+ G++L   A   +CVD+NEC   + C     C N  G + C C  GY 
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 692

Query: 285 LSSDRLN-CEDIDECRTSSYLCQYQCVNEPGKFSCM-CPQGYQVVRSRTCQDINECETTN 342
           L + R   CEDIDECR  S     +C N+PG F C+ C  GY+      C+D+NEC   +
Sbjct: 693 LKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGS 752

Query: 343 ECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPV---------SNAMCRELPQSI 393
            C     C N  G FRC     C   Y   P+ R    V          N +C   P S 
Sbjct: 753 PC-SPGWCENLPGSFRC----TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF 807

Query: 394 VYKYMS---IRSDRSVPSDIFQ--IQATTIYANTINT 425
             + +S   +  DRS   DI +    A  I  + INT
Sbjct: 808 QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844



 Score =  109 bits (273), Expect = 5e-24
 Identities = 111/421 (26%), Positives = 163/421 (38%), Gaps = 78/421 (18%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVNNEQ---------- 83
           C+DI+EC  +P  C+ G  C+N+ G Y C+        P   Q I +  +          
Sbjct: 353 CQDINEC-AMPGVCRHG-DCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410

Query: 84  PQQETQPAEGTS--------------GA------TTGVVAASSMATSGVLPGGGFVASAA 123
           P+ + Q    T               GA      T G  A   +  +G    G  + ++ 
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK---GYHILTSH 467

Query: 124 AVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDE------- 176
                + ++  + F+    P  PQ++P +PS         E+        + E       
Sbjct: 468 QTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQS 527

Query: 177 -CTAGTHNCRADQVCINLRGS-----FACQCPPG---YQKRGEQCVDIDECTIPPYC--H 225
             TA T   R     I+         F    PP     +    Q  + DEC +      H
Sbjct: 528 HPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGH 587

Query: 226 QRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ---CYNILGSFICQCNQG 282
             CV  P  + C C+PG++    +  CVD+NEC+A   C      C N  GS+ C CN+G
Sbjct: 588 GECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRG 646

Query: 283 YEL--SSDRLNCEDIDECRTSSYLCQYQ--CVNEPGKFSCMCPQGYQVVRSR--TCQDIN 336
           Y L   +   +C D++EC    +LC     C+N PG + C C  GY++  SR   C+DI+
Sbjct: 647 YRLHVGAGGRSCVDLNEC-AKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDID 705

Query: 337 ECETTNECREDEMCWNYHGGFRCYPRNP---CQDPYILTPENRCV--CPVSNAMCRELPQ 391
           EC   + C  D  C N  G F+C    P    Q        N C    P S   C  LP 
Sbjct: 706 ECRDPSSC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPG 764

Query: 392 S 392
           S
Sbjct: 765 S 765



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 98/394 (24%), Positives = 140/394 (35%), Gaps = 94/394 (23%)

Query: 40   QQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNN----EQPQQETQPAEGTS 95
            ++C+DIDEC   P  C     C N  G Y+C+         +    E+ +Q     E   
Sbjct: 862  RKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYL 921

Query: 96   GATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH 155
                 V   S +AT+  +       S  A  G   +              P  + S+   
Sbjct: 922  NFDDTVFCDSVLATN--VTQQECCCSLGAGWGDHCEIY------------PCPVYSSAEF 967

Query: 156  RIQC--AAGYEQSEHNVC------QDIDECTA-GTHNCRADQVCINLRGSFACQCPPGYQ 206
               C    GY Q  + V       +DIDEC   G+  C+  + C+N +  + C C  G+ 
Sbjct: 968  HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK-CVNTQPGYECYCKQGFY 1026

Query: 207  KRGE--QCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ 263
              G   +CVD+DEC     C    C NT G + C C+P  + +     C+   E + + +
Sbjct: 1027 YDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPE 1086

Query: 264  CAQQCYNILGS---------------FICQCNQGYELSSDRLNC---------------- 292
                C++  G                  C C QG    +    C                
Sbjct: 1087 RRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSES 1146

Query: 293  ----------------------EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR 330
                                  ED DECR  S     +CV  PG   C CP G+Q+  SR
Sbjct: 1147 NSFWDTSPLLLGKPPRDEDSSEEDSDECRCVS----GRCVPRPGGAVCECPGGFQLDASR 1202

Query: 331  T-CQDINECETTNE----CREDEMCWNYHGGFRC 359
              C DI+EC   N+    C+  E C N  G FRC
Sbjct: 1203 ARCVDIDECRELNQRGLLCK-SERCVNTSGSFRC 1235



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 74/254 (29%), Positives = 110/254 (43%), Gaps = 39/254 (15%)

Query: 149  IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR 208
            I +N S+R  C  G+       CQDIDEC+     C     C NL+GS+ C C  G+   
Sbjct: 842  INTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPT 901

Query: 209  GEQ--CVDIDECTIPPYCHQRC-VNTPGSFYCQCSPGFQLAANNYTCVDINECDAS---- 261
             +Q  C ++++    P+  + C +N   + +C       LA N    V   EC  S    
Sbjct: 902  QDQHGCEEVEQ----PHHKKECYLNFDDTVFCDS----VLATN----VTQQECCCSLGAG 949

Query: 262  --NQCAQQCYNILGS----FICQCNQGYELSSDRLNC-----EDIDECRT-SSYLC-QYQ 308
              + C      +  S     +C   +GY   ++ +N       DIDEC    S +C + +
Sbjct: 950  WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGK 1009

Query: 309  CVNEPGKFSCMCPQG-YQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQD 367
            CVN    + C C QG Y       C D++EC   + CR + +C N  GG+RC     C  
Sbjct: 1010 CVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR-NGVCENTRGGYRC----ACTP 1064

Query: 368  PYILTPENR-CVCP 380
            P   +P  R C+ P
Sbjct: 1065 PAEYSPAQRQCLSP 1078



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 77/293 (26%), Positives = 108/293 (36%), Gaps = 45/293 (15%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
            QC  GY     R  C+DIDECD  P AC GG  C+N  G Y CL      +V   + Q  
Sbjct: 810  QCLSGYHLSRDRSHCEDIDECDF-PAACIGG-DCINTNGSYRCLCPQGHRLVGGRKCQD- 866

Query: 88   TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                          +   S   S  LP G    +   + G  +      F   ++    +
Sbjct: 867  --------------IDECSQDPSLCLPHG----ACKNLQGSYVCVCDEGFTPTQDQHGCE 908

Query: 148  RIPSNPSHRIQCAAGYEQS-------EHNVCQDIDECTAGT---HNCRADQVCINLRGSF 197
             +   P H+ +C   ++ +         NV Q    C+ G     +C      +     F
Sbjct: 909  EV-EQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEF 967

Query: 198  ACQCPPGYQKRGEQCV---------DIDECTI--PPYCHQ-RCVNTPGSFYCQCSPGFQL 245
               CP G     +  +         DIDEC +     C + +CVNT   + C C  GF  
Sbjct: 968  HSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY 1027

Query: 246  AANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
              N   CVD++EC D SN     C N  G + C C    E S  +  C   +E
Sbjct: 1028 DGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE 1080



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 76/276 (27%), Positives = 102/276 (36%), Gaps = 58/276 (21%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G+ +D    +C D+DEC +    C+ G+ C N  GGY C             P  E 
Sbjct: 1021 CKQGFYYDGNLLECVDVDEC-LDESNCRNGV-CENTRGGYRCACT----------PPAEY 1068

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEM-------QTGRNNFVIRR 141
             PA+    +   +  A           G     A  +AGP +       + GR  +  + 
Sbjct: 1069 SPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRG-WGAQC 1127

Query: 142  NPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQC 201
             P  P+   S+      C     QSE N   D      G                     
Sbjct: 1128 RPCPPRGAGSH------CPTS--QSESNSFWDTSPLLLGK-------------------- 1159

Query: 202  PPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS 261
            PP  +   E+  D DEC        RCV  PG   C+C  GFQL A+   CVDI+EC   
Sbjct: 1160 PPRDEDSSEE--DSDECRC---VSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL 1214

Query: 262  NQ----C-AQQCYNILGSFICQCNQGYELSSDRLNC 292
            NQ    C +++C N  GSF C C  G+  S     C
Sbjct: 1215 NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 61/239 (25%)

Query: 149  IPSNPSHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPG--Y 205
            + + P +   C  G+    + + C D+DEC   + NCR + VC N RG + C C P   Y
Sbjct: 1011 VNTQPGYECYCKQGFYYDGNLLECVDVDECLDES-NCR-NGVCENTRGGYRCACTPPAEY 1068

Query: 206  QKRGEQCVDIDECTIPPYCHQRCVNTPGS-------------------------FYCQCS 240
                 QC+  +E    P     C +  G                          +  QC 
Sbjct: 1069 SPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCR 1128

Query: 241  PGFQLAANNYTCVDINECDA----------------------SNQC---AQQCYNILGSF 275
            P     A ++     +E ++                      S++C   + +C    G  
Sbjct: 1129 PCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGA 1188

Query: 276  ICQCNQGYELSSDRLNCEDIDECR---TSSYLCQYQ-CVNEPGKFSCMCPQGYQVVRSR 330
            +C+C  G++L + R  C DIDECR       LC+ + CVN  G F C+C  G+   RSR
Sbjct: 1189 VCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF--ARSR 1245



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 193 LRGSFACQCPPGYQK-RGEQCVDIDECTIPPYC-HQRCVNTPGSFYCQCSPGFQLAANNY 250
           +RG     CP GY++     C DI+EC +P  C H  C+N PGS+ C C PG  L  +  
Sbjct: 333 VRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 392

Query: 251 TCVDINECDAS---------NQCAQQCYNILGSFICQCNQG 282
            C+     + S         +QC       L   +C C+ G
Sbjct: 393 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 31/142 (21%)

Query: 271 ILGSFICQCNQGYELSSDRLN---CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVV 327
           + G     C QGY+    RLN   C+DI+EC          C+N PG + C+CP G+ + 
Sbjct: 333 VRGEVGADCPQGYK----RLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLG 388

Query: 328 RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCR 387
            SRT     +C   ++  E  +C+                  +++PE++C  P++  + R
Sbjct: 389 PSRT-----QC-IADKPEEKSLCFR-----------------LVSPEHQCQHPLTTRLTR 425

Query: 388 ELPQSIVYKYMSIRSDRSVPSD 409
           +L    V K    R  R  P+D
Sbjct: 426 QLCCCSVGKAWGARCQR-CPTD 446



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 27/168 (16%)

Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRC-------VNTPGSFY----CQCSPGFQLAANNYT 251
           PG  K+ + C  I        CH +C       V  PG         C  G++   N+  
Sbjct: 295 PGLTKQEDCCGSIGTAWGQSKCH-KCPQLQYTGVQKPGPVRGEVGADCPQGYK-RLNSTH 352

Query: 252 CVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC-----EDIDEC---RTSS 302
           C DINEC     C    C N  GS+ C C  G+ L   R  C     E+   C    +  
Sbjct: 353 CQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPE 412

Query: 303 YLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMC 350
           + CQ+       +  C C  G        CQ    C T       E+C
Sbjct: 413 HQCQHPLTTRLTRQLCCCSVG--KAWGARCQ---RCPTDGTAAFKEIC 455



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 21/47 (44%), Positives = 27/47 (57%), Gaps = 2/47 (4%)

Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           C  GY++     CQDI+EC A    CR    C+N  GS+ C CPPG+
Sbjct: 341 CPQGYKRLNSTHCQDINEC-AMPGVCRHGD-CLNNPGSYRCVCPPGH 385



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPD---ACKGGMKCVNHYGGYLCLPK 73
            +C  G++ D  R +C DIDEC  +      CK   +CVN  G + C+ K
Sbjct: 1191 ECPGGFQLDASRARCVDIDECRELNQRGLLCK-SERCVNTSGSFRCVCK 1238


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score =  158 bits (400), Expect = 9e-39
 Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
           C  G+   P   +C D+DEC  VP  C  G +C N  G + C+        P+ A+ +  
Sbjct: 505 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 563

Query: 81  NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
           +E     P  +    E T G+   V  A   A     P G                GR  
Sbjct: 564 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 619

Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
                     + +P   S R  C AG+  S     +D+DEC      C   + C N  GS
Sbjct: 620 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 665

Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
           F C CP G++ R  G  C D+DEC  + PP  + RC NT GSF C C  GFQ       C
Sbjct: 666 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 725

Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
            D++EC+    C  Q+C N  GSF C+ C  G+ L   R  C D+DEC + +  C     
Sbjct: 726 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 783

Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
           C N  G F C C  GY+    R   C D+NEC   + C     C N  G F C     C 
Sbjct: 784 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 839

Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
             Y   P       V      +L QS
Sbjct: 840 PGYRPGPRGASCLDVDECSEEDLCQS 865



 Score =  155 bits (392), Expect = 8e-38
 Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G+        C+D+DEC   P  C  G +C N  G + C      +     QP    
Sbjct: 670  CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 722

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
               E        +        +      G        +G  +  GR   V   +   P  
Sbjct: 723  SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 778

Query: 149  IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
             P      +  S R  CA GY         C D++EC  G   C     C+N  GSFAC 
Sbjct: 779  GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 837

Query: 201  CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
            C PGY+   RG  C+D+DEC+    C    C NT GSF C C PG +   +  +C+D++E
Sbjct: 838  CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 897

Query: 258  C--------------------------------------DASNQC---------AQQCYN 270
            C                                      D  ++C         AQ+C N
Sbjct: 898  CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 957

Query: 271  ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
              GS+ C   C+ GY+ +     C+D+DECR  S+   +  C N PG F C+C QGY+  
Sbjct: 958  TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016

Query: 328  R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
            R  R C D+NECET        +C N  G F C  P +P + DP       RCV P ++A
Sbjct: 1017 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1072



 Score =  154 bits (390), Expect = 1e-37
 Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
           C  G+   P   +C D+DEC  VP  C  G +C N  G +LC+ P   Q   +    Q  
Sbjct: 547 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 605

Query: 88  TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
            +  +       G            LPG       A   G   +   +       P  P 
Sbjct: 606 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 657

Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           R  +   S    C AG+        CQD+DEC      C   + C N  GSF C CP G+
Sbjct: 658 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 716

Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
           Q    G +C D+DEC     C  Q CVN+PGSF C+ C  G  L  +   C D++EC + 
Sbjct: 717 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 774

Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
           +  C     C N  GSF C C  GY   S R   C D++EC    +   + +C+N  G F
Sbjct: 775 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 834

Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           +C C  GY+   R  +C D++EC   + C +  +C N  G F C
Sbjct: 835 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 877



 Score =  153 bits (387), Expect = 3e-37
 Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)

Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
           S  A  GPE+ ++G ++ + +RNP    P R  S PS +   C +G+  S     C D+D
Sbjct: 463 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 522

Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
           EC      C   + C N  GSF C C PG++   R  +C+D+DEC  +PP C   RC NT
Sbjct: 523 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 581

Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
           PGSF C C  G+Q A +  +C D++EC  S                              
Sbjct: 582 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 641

Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
              ++CAQ+        C N  GSF C C  G+        C+D+DEC  S   C Y +C
Sbjct: 642 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 701

Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            N  G F C+CP G+Q       C+D++ECE    C   E C N  G F+C
Sbjct: 702 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 751



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
            C  GYE     + C D++EC+ +   C G   C N  G +LC+                 
Sbjct: 1009 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1067

Query: 72   PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
            P+T+       QPQ    P          +    S    G + G G        A P+  
Sbjct: 1068 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1126

Query: 132  TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
                  ++ RN    +   +         RIQ   G E +E+ ++C              
Sbjct: 1127 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1182

Query: 172  --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
              +D+DEC           VC+N    ++C C  GY    +  +C+D DEC    P C  
Sbjct: 1183 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1242

Query: 227  -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
             RCVNT GS++C C P   L  +   CV  NE  + +     C+  +G+
Sbjct: 1243 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1290



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
            C  G+   P    C D+DEC     A  G  +C N  G Y C+             T   
Sbjct: 879  CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 938

Query: 78   IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
            +   ++   E   A+     T G    +     G    PGGG           ++   RN
Sbjct: 939  VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 988

Query: 136  NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
                  + A  Q +P   S +  C  GYE + +   C D++EC      C A  +C N+ 
Sbjct: 989  RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1044

Query: 195  GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
            GSF C CP                       PG Q +      +     PP   +R  +T
Sbjct: 1045 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1103

Query: 232  P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
            P     GS   +C     +P     + A N T    C  + E   S    QQC     + 
Sbjct: 1104 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1163

Query: 275  --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
               +C   +GY   S  L+   D+DEC+     +C+   CVN    +SC C  GY     
Sbjct: 1164 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1223

Query: 330  R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
            R  C D +EC       E   C N  G + C     C+ P +L   + RCV   S ++
Sbjct: 1224 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1277



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)

Query: 120  ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
            + A A  GP  +    +   RR+  +P+  P   S+    A  YE+ E   C  +D CT 
Sbjct: 1419 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1478

Query: 180  GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
            G         C+ +   F C+C  GY+       CVDI+EC       P C + RC+NT 
Sbjct: 1479 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1530

Query: 233  GSFYCQCSPGFQLAANNYTC 252
            GSF C C PGF      + C
Sbjct: 1531 GSFRCICRPGFAPTHQPHHC 1550



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)

Query: 195  GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            GS+A      Y++   E+C  +D CT     + RCV  P  F C+C  G++L      CV
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1506

Query: 254  DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
            DINECD    AS  C   +C N  GSF C C  G+  +    +C
Sbjct: 1507 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 247  ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
            A  Y  ++  EC   + C   +C  +   F C+C  GY L   R+ C DI+EC     +S
Sbjct: 1459 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1518

Query: 303  YLC-QYQCVNEPGKFSCMCPQGY 324
             LC   +C+N  G F C+C  G+
Sbjct: 1519 PLCVNARCLNTDGSFRCICRPGF 1541



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)

Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
           G H+C   Q+C    G+          CP G+++    C D+DEC     C H  C NT 
Sbjct: 253 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 309

Query: 233 GSFYCQCSPGFQLAANNYTCV 253
           G + C C  GF L ++  +C+
Sbjct: 310 GGYTCVCPDGFLLDSSRSSCI 330



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)

Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
           C  G+E  +   +CED+DEC T       +C N  G ++C+CP G+ +  SR+
Sbjct: 277 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 327



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)

Query: 294  DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
            + +EC         +CV  P  F+C C  GY++  +R  C DINEC   E  +    +  
Sbjct: 1466 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1525

Query: 350  CWNYHGGFRCYPR---NPCQDPYILTP 373
            C N  G FRC  R    P   P+   P
Sbjct: 1526 CLNTDGSFRCICRPGFAPTHQPHHCAP 1552



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)

Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
           C  GF+    N +C D++EC    +C   +C N  G + C C  G+ L S R +C
Sbjct: 277 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 329



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)

Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           C  G+E+   + C+D+DEC  G   C+  + C N RG + C CP G+
Sbjct: 277 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 320



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
           CP G++ V   +C+D++EC T   C+  E C N  GG+ C     C D ++L
Sbjct: 277 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 322



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
            +C DGY  D  R  C DI+ECD    A       +C+N  G + C+
Sbjct: 1491 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
           C  G+E   V   C+D+DEC      C+ G +C N  GGY C+
Sbjct: 277 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 315


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score =  158 bits (400), Expect = 9e-39
 Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
           C  G+   P   +C D+DEC  VP  C  G +C N  G + C+        P+ A+ +  
Sbjct: 535 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 593

Query: 81  NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
           +E     P  +    E T G+   V  A   A     P G                GR  
Sbjct: 594 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 649

Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
                     + +P   S R  C AG+  S     +D+DEC      C   + C N  GS
Sbjct: 650 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 695

Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
           F C CP G++ R  G  C D+DEC  + PP  + RC NT GSF C C  GFQ       C
Sbjct: 696 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 755

Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
            D++EC+    C  Q+C N  GSF C+ C  G+ L   R  C D+DEC + +  C     
Sbjct: 756 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 813

Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
           C N  G F C C  GY+    R   C D+NEC   + C     C N  G F C     C 
Sbjct: 814 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 869

Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
             Y   P       V      +L QS
Sbjct: 870 PGYRPGPRGASCLDVDECSEEDLCQS 895



 Score =  155 bits (392), Expect = 8e-38
 Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G+        C+D+DEC   P  C  G +C N  G + C      +     QP    
Sbjct: 700  CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 752

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
               E        +        +      G        +G  +  GR   V   +   P  
Sbjct: 753  SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 808

Query: 149  IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
             P      +  S R  CA GY         C D++EC  G   C     C+N  GSFAC 
Sbjct: 809  GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 867

Query: 201  CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
            C PGY+   RG  C+D+DEC+    C    C NT GSF C C PG +   +  +C+D++E
Sbjct: 868  CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 927

Query: 258  C--------------------------------------DASNQC---------AQQCYN 270
            C                                      D  ++C         AQ+C N
Sbjct: 928  CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 987

Query: 271  ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
              GS+ C   C+ GY+ +     C+D+DECR  S+   +  C N PG F C+C QGY+  
Sbjct: 988  TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1046

Query: 328  R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
            R  R C D+NECET        +C N  G F C  P +P + DP       RCV P ++A
Sbjct: 1047 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1102



 Score =  154 bits (390), Expect = 1e-37
 Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
           C  G+   P   +C D+DEC  VP  C  G +C N  G +LC+ P   Q   +    Q  
Sbjct: 577 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 635

Query: 88  TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
            +  +       G            LPG       A   G   +   +       P  P 
Sbjct: 636 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 687

Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           R  +   S    C AG+        CQD+DEC      C   + C N  GSF C CP G+
Sbjct: 688 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 746

Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
           Q    G +C D+DEC     C  Q CVN+PGSF C+ C  G  L  +   C D++EC + 
Sbjct: 747 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 804

Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
           +  C     C N  GSF C C  GY   S R   C D++EC    +   + +C+N  G F
Sbjct: 805 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 864

Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           +C C  GY+   R  +C D++EC   + C +  +C N  G F C
Sbjct: 865 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 907



 Score =  153 bits (387), Expect = 3e-37
 Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)

Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
           S  A  GPE+ ++G ++ + +RNP    P R  S PS +   C +G+  S     C D+D
Sbjct: 493 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 552

Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
           EC      C   + C N  GSF C C PG++   R  +C+D+DEC  +PP C   RC NT
Sbjct: 553 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 611

Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
           PGSF C C  G+Q A +  +C D++EC  S                              
Sbjct: 612 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 671

Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
              ++CAQ+        C N  GSF C C  G+        C+D+DEC  S   C Y +C
Sbjct: 672 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 731

Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            N  G F C+CP G+Q       C+D++ECE    C   E C N  G F+C
Sbjct: 732 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 781



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
            C  GYE     + C D++EC+ +   C G   C N  G +LC+                 
Sbjct: 1039 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1097

Query: 72   PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
            P+T+       QPQ    P          +    S    G + G G        A P+  
Sbjct: 1098 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1156

Query: 132  TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
                  ++ RN    +   +         RIQ   G E +E+ ++C              
Sbjct: 1157 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1212

Query: 172  --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
              +D+DEC           VC+N    ++C C  GY    +  +C+D DEC    P C  
Sbjct: 1213 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1272

Query: 227  -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
             RCVNT GS++C C P   L  +   CV  NE  + +     C+  +G+
Sbjct: 1273 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1320



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
            C  G+   P    C D+DEC     A  G  +C N  G Y C+             T   
Sbjct: 909  CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 968

Query: 78   IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
            +   ++   E   A+     T G    +     G    PGGG           ++   RN
Sbjct: 969  VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 1018

Query: 136  NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
                  + A  Q +P   S +  C  GYE + +   C D++EC      C A  +C N+ 
Sbjct: 1019 RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1074

Query: 195  GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
            GSF C CP                       PG Q +      +     PP   +R  +T
Sbjct: 1075 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1133

Query: 232  P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
            P     GS   +C     +P     + A N T    C  + E   S    QQC     + 
Sbjct: 1134 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1193

Query: 275  --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
               +C   +GY   S  L+   D+DEC+     +C+   CVN    +SC C  GY     
Sbjct: 1194 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1253

Query: 330  R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
            R  C D +EC       E   C N  G + C     C+ P +L   + RCV   S ++
Sbjct: 1254 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1307



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)

Query: 120  ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
            + A A  GP  +    +   RR+  +P+  P   S+    A  YE+ E   C  +D CT 
Sbjct: 1449 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1508

Query: 180  GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
            G         C+ +   F C+C  GY+       CVDI+EC       P C + RC+NT 
Sbjct: 1509 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1560

Query: 233  GSFYCQCSPGFQLAANNYTC 252
            GSF C C PGF      + C
Sbjct: 1561 GSFRCICRPGFAPTHQPHHC 1580



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)

Query: 195  GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            GS+A      Y++   E+C  +D CT     + RCV  P  F C+C  G++L      CV
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1536

Query: 254  DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
            DINECD    AS  C   +C N  GSF C C  G+  +    +C
Sbjct: 1537 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 247  ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
            A  Y  ++  EC   + C   +C  +   F C+C  GY L   R+ C DI+EC     +S
Sbjct: 1489 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1548

Query: 303  YLC-QYQCVNEPGKFSCMCPQGY 324
             LC   +C+N  G F C+C  G+
Sbjct: 1549 PLCVNARCLNTDGSFRCICRPGF 1571



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)

Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
           G H+C   Q+C    G+          CP G+++    C D+DEC     C H  C NT 
Sbjct: 283 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 339

Query: 233 GSFYCQCSPGFQLAANNYTCV 253
           G + C C  GF L ++  +C+
Sbjct: 340 GGYTCVCPDGFLLDSSRSSCI 360



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)

Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
           C  G+E  +   +CED+DEC T       +C N  G ++C+CP G+ +  SR+
Sbjct: 307 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 357



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)

Query: 294  DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
            + +EC         +CV  P  F+C C  GY++  +R  C DINEC   E  +    +  
Sbjct: 1496 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1555

Query: 350  CWNYHGGFRCYPR---NPCQDPYILTP 373
            C N  G FRC  R    P   P+   P
Sbjct: 1556 CLNTDGSFRCICRPGFAPTHQPHHCAP 1582



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)

Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
           C  GF+    N +C D++EC    +C   +C N  G + C C  G+ L S R +C
Sbjct: 307 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 359



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)

Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           C  G+E+   + C+D+DEC  G   C+  + C N RG + C CP G+
Sbjct: 307 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 350



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
           CP G++ V   +C+D++EC T   C+  E C N  GG+ C     C D ++L
Sbjct: 307 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 352



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
            +C DGY  D  R  C DI+ECD    A       +C+N  G + C+
Sbjct: 1521 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
           C  G+E   V   C+D+DEC      C+ G +C N  GGY C+
Sbjct: 307 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 345


>gi|110347431 latent transforming growth factor beta binding protein
           4 isoform a [Homo sapiens]
          Length = 1624

 Score =  158 bits (400), Expect = 9e-39
 Identities = 121/386 (31%), Positives = 157/386 (40%), Gaps = 47/386 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL--------PKTAQIIVN 80
           C  G+   P   +C D+DEC  VP  C  G +C N  G + C+        P+ A+ +  
Sbjct: 572 CDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDV 630

Query: 81  NE----QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNN 136
           +E     P  +    E T G+   V  A   A     P G                GR  
Sbjct: 631 DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAA----PHGASCQDVDECTQSPGLCGRGA 686

Query: 137 FVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGS 196
                     + +P   S R  C AG+  S     +D+DEC      C   + C N  GS
Sbjct: 687 C---------KNLPG--SFRCVCPAGFRGSACE--EDVDECAQEPPPCGPGR-CDNTAGS 732

Query: 197 FACQCPPGYQKR--GEQCVDIDEC--TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC 252
           F C CP G++ R  G  C D+DEC  + PP  + RC NT GSF C C  GFQ       C
Sbjct: 733 FHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSEC 792

Query: 253 VDINECDASNQC-AQQCYNILGSFICQ-CNQGYELSSDRLNCEDIDECRTSSYLC--QYQ 308
            D++EC+    C  Q+C N  GSF C+ C  G+ L   R  C D+DEC + +  C     
Sbjct: 793 EDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGH 850

Query: 309 CVNEPGKFSCMCPQGYQVVRSR--TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQ 366
           C N  G F C C  GY+    R   C D+NEC   + C     C N  G F C     C 
Sbjct: 851 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFAC----TCA 906

Query: 367 DPYILTPENRCVCPVSNAMCRELPQS 392
             Y   P       V      +L QS
Sbjct: 907 PGYRPGPRGASCLDVDECSEEDLCQS 932



 Score =  155 bits (392), Expect = 8e-38
 Identities = 121/420 (28%), Positives = 165/420 (39%), Gaps = 81/420 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
            C  G+        C+D+DEC   P  C  G +C N  G + C      +     QP    
Sbjct: 737  CPAGFRSRGPGAPCQDVDECARSPPPCTYG-RCENTEGSFQC------VCPMGFQPNTAG 789

Query: 89   QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQR 148
               E        +        +      G        +G  +  GR   V   +   P  
Sbjct: 790  SECEDVDECENHLACPGQECVNSP----GSFQCRTCPSGHHLHRGRCTDVDECSSGAPPC 845

Query: 149  IP------SNPSHRIQCAAGYE--QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQ 200
             P      +  S R  CA GY         C D++EC  G   C     C+N  GSFAC 
Sbjct: 846  GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGECLNTDGSFACT 904

Query: 201  CPPGYQK--RGEQCVDIDECTIPPYCHQR-CVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
            C PGY+   RG  C+D+DEC+    C    C NT GSF C C PG +   +  +C+D++E
Sbjct: 905  CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 964

Query: 258  C--------------------------------------DASNQC---------AQQCYN 270
            C                                      D  ++C         AQ+C N
Sbjct: 965  CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 1024

Query: 271  ILGSFICQ--CNQGYELSSDRLNCEDIDECRTSSYLCQYQ-CVNEPGKFSCMCPQGYQVV 327
              GS+ C   C+ GY+ +     C+D+DECR  S+   +  C N PG F C+C QGY+  
Sbjct: 1025 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1083

Query: 328  R-SRTCQDINECETTNECREDEMCWNYHGGFRCY-PRNPCQ-DPYILTPENRCVCPVSNA 384
            R  R C D+NECET        +C N  G F C  P +P + DP       RCV P ++A
Sbjct: 1084 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM----TGRCVPPRTSA 1139



 Score =  154 bits (390), Expect = 1e-37
 Identities = 108/344 (31%), Positives = 147/344 (42%), Gaps = 26/344 (7%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL-PKTAQIIVNNEQPQQE 87
           C  G+   P   +C D+DEC  VP  C  G +C N  G +LC+ P   Q   +    Q  
Sbjct: 614 CGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPAGYQAAPHGASCQDV 672

Query: 88  TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
            +  +       G            LPG       A   G   +   +       P  P 
Sbjct: 673 DECTQSPGLCGRGACKN--------LPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPG 724

Query: 148 RIPSNP-SHRIQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           R  +   S    C AG+        CQD+DEC      C   + C N  GSF C CP G+
Sbjct: 725 RCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGF 783

Query: 206 QKR--GEQCVDIDECTIPPYC-HQRCVNTPGSFYCQ-CSPGFQLAANNYTCVDINECDA- 260
           Q    G +C D+DEC     C  Q CVN+PGSF C+ C  G  L  +   C D++EC + 
Sbjct: 784 QPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHL--HRGRCTDVDECSSG 841

Query: 261 SNQCAQ--QCYNILGSFICQCNQGYELSSDRLN-CEDIDECRTSSYLCQY-QCVNEPGKF 316
           +  C     C N  GSF C C  GY   S R   C D++EC    +   + +C+N  G F
Sbjct: 842 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 901

Query: 317 SCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           +C C  GY+   R  +C D++EC   + C +  +C N  G F C
Sbjct: 902 ACTCAPGYRPGPRGASCLDVDECSEEDLC-QSGICTNTDGSFEC 944



 Score =  153 bits (387), Expect = 3e-37
 Identities = 99/291 (34%), Positives = 135/291 (46%), Gaps = 54/291 (18%)

Query: 121 SAAAVAGPEM-QTGRNNFVIRRNP--ADPQRIPSNPS-HRIQCAAGYEQSEHNV-CQDID 175
           S  A  GPE+ ++G ++ + +RNP    P R  S PS +   C +G+  S     C D+D
Sbjct: 530 SIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVD 589

Query: 176 ECTAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDEC-TIPPYCHQ-RCVNT 231
           EC      C   + C N  GSF C C PG++   R  +C+D+DEC  +PP C   RC NT
Sbjct: 590 ECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT 648

Query: 232 PGSFYCQCSPGFQLAANNYTCVDINECDAS------------------------------ 261
           PGSF C C  G+Q A +  +C D++EC  S                              
Sbjct: 649 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACE 708

Query: 262 ---NQCAQQ--------CYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY-QC 309
              ++CAQ+        C N  GSF C C  G+        C+D+DEC  S   C Y +C
Sbjct: 709 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRC 768

Query: 310 VNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
            N  G F C+CP G+Q       C+D++ECE    C   E C N  G F+C
Sbjct: 769 ENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQE-CVNSPGSFQC 818



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 71/289 (24%), Positives = 107/289 (37%), Gaps = 50/289 (17%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL----------------- 71
            C  GYE     + C D++EC+ +   C G   C N  G +LC+                 
Sbjct: 1076 CDQGYEGARDGRHCVDVNECETLQGVC-GAALCENVEGSFLCVCPNSPEEFDPMTGRCVP 1134

Query: 72   PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQ 131
            P+T+       QPQ    P          +    S    G + G G        A P+  
Sbjct: 1135 PRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPV-GSGRRECYFDTAAPDAC 1193

Query: 132  TGRNNFVIRRNPADPQRIPS-----NPSHRIQCAAGYEQSEH-NVC-------------- 171
                  ++ RN    +   +         RIQ   G E +E+ ++C              
Sbjct: 1194 DN----ILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLS 1249

Query: 172  --QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECTIP-PYCHQ 226
              +D+DEC           VC+N    ++C C  GY    +  +C+D DEC    P C  
Sbjct: 1250 LRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEG 1309

Query: 227  -RCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGS 274
             RCVNT GS++C C P   L  +   CV  NE  + +     C+  +G+
Sbjct: 1310 GRCVNTVGSYHCTCEPPLVLDGSQRRCVS-NESQSLDDNLGVCWQEVGA 1357



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 105/418 (25%), Positives = 149/418 (35%), Gaps = 80/418 (19%)

Query: 29   CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPK-----------TAQI 77
            C  G+   P    C D+DEC     A  G  +C N  G Y C+             T   
Sbjct: 946  CPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDD 1005

Query: 78   IVNNEQPQQETQPAEGTSGATTGVVAASSMATSGV--LPGGGFVASAAAVAGPEMQTGRN 135
            +   ++   E   A+     T G    +     G    PGGG           ++   RN
Sbjct: 1006 VDECQEYGPEICGAQRCEN-TPGSYRCTPACDPGYQPTPGGGC---------QDVDECRN 1055

Query: 136  NFVIRRNPADPQRIPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLR 194
                  + A  Q +P   S +  C  GYE + +   C D++EC      C A  +C N+ 
Sbjct: 1056 RSFCGAH-AVCQNLPG--SFQCLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVE 1111

Query: 195  GSFACQCP-----------------------PGYQKRGEQCVDIDECTIPPYCHQRCVNT 231
            GSF C CP                       PG Q +      +     PP   +R  +T
Sbjct: 1112 GSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR-PST 1170

Query: 232  P-----GSFYCQC-----SPGF--QLAANNYT----CVDINECDASNQCAQQCYNILGS- 274
            P     GS   +C     +P     + A N T    C  + E   S    QQC     + 
Sbjct: 1171 PRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAE 1230

Query: 275  --FICQCNQGYELSSDRLNCE-DIDECRT-SSYLCQYQ-CVNEPGKFSCMCPQGYQVVRS 329
               +C   +GY   S  L+   D+DEC+     +C+   CVN    +SC C  GY     
Sbjct: 1231 YQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQ 1290

Query: 330  R-TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILT-PENRCVCPVSNAM 385
            R  C D +EC       E   C N  G + C     C+ P +L   + RCV   S ++
Sbjct: 1291 RLECIDNDECADEEPACEGGRCVNTVGSYHC----TCEPPLVLDGSQRRCVSNESQSL 1344



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 45/140 (32%), Positives = 62/140 (44%), Gaps = 15/140 (10%)

Query: 120  ASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTA 179
            + A A  GP  +    +   RR+  +P+  P   S+    A  YE+ E   C  +D CT 
Sbjct: 1486 SEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTN 1545

Query: 180  GTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC----TIPPYC-HQRCVNTP 232
            G         C+ +   F C+C  GY+       CVDI+EC       P C + RC+NT 
Sbjct: 1546 GR--------CVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTD 1597

Query: 233  GSFYCQCSPGFQLAANNYTC 252
            GSF C C PGF      + C
Sbjct: 1598 GSFRCICRPGFAPTHQPHHC 1617



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 38/104 (36%), Positives = 51/104 (49%), Gaps = 11/104 (10%)

Query: 195  GSFACQCPPGYQK-RGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCV 253
            GS+A      Y++   E+C  +D CT     + RCV  P  F C+C  G++L      CV
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCT-----NGRCVRVPEGFTCRCFDGYRLDMTRMACV 1573

Query: 254  DINECD----ASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
            DINECD    AS  C   +C N  GSF C C  G+  +    +C
Sbjct: 1574 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 5/83 (6%)

Query: 247  ANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDEC---RTSS 302
            A  Y  ++  EC   + C   +C  +   F C+C  GY L   R+ C DI+EC     +S
Sbjct: 1526 AEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAAS 1585

Query: 303  YLC-QYQCVNEPGKFSCMCPQGY 324
             LC   +C+N  G F C+C  G+
Sbjct: 1586 PLCVNARCLNTDGSFRCICRPGF 1608



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 10/81 (12%)

Query: 180 GTHNCRADQVCINLRGSFAC------QCPPGYQKRGEQCVDIDECTIPPYC-HQRCVNTP 232
           G H+C   Q+C    G+          CP G+++    C D+DEC     C H  C NT 
Sbjct: 320 GVHDC---QLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTR 376

Query: 233 GSFYCQCSPGFQLAANNYTCV 253
           G + C C  GF L ++  +C+
Sbjct: 377 GGYTCVCPDGFLLDSSRSSCI 397



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 2/53 (3%)

Query: 279 CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRT 331
           C  G+E  +   +CED+DEC T       +C N  G ++C+CP G+ +  SR+
Sbjct: 344 CPTGFERVNG--SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRS 394



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)

Query: 294  DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR-TCQDINEC---ETTNECREDEM 349
            + +EC         +CV  P  F+C C  GY++  +R  C DINEC   E  +    +  
Sbjct: 1533 EAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNAR 1592

Query: 350  CWNYHGGFRCYPR---NPCQDPYILTP 373
            C N  G FRC  R    P   P+   P
Sbjct: 1593 CLNTDGSFRCICRPGFAPTHQPHHCAP 1619



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 3/55 (5%)

Query: 239 CSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC 292
           C  GF+    N +C D++EC    +C   +C N  G + C C  G+ L S R +C
Sbjct: 344 CPTGFERV--NGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC 396



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)

Query: 159 CAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
           C  G+E+   + C+D+DEC  G   C+  + C N RG + C CP G+
Sbjct: 344 CPTGFERVNGS-CEDVDECATG-GRCQHGE-CANTRGGYTCVCPDGF 387



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 6/52 (11%)

Query: 320 CPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL 371
           CP G++ V   +C+D++EC T   C+  E C N  GG+ C     C D ++L
Sbjct: 344 CPTGFERVNG-SCEDVDECATGGRCQHGE-CANTRGGYTCV----CPDGFLL 389



 Score = 35.8 bits (81), Expect = 0.091
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 2/46 (4%)

Query: 28   QCTDGYEWDPVRQQCKDIDECDIVPDACK--GGMKCVNHYGGYLCL 71
            +C DGY  D  R  C DI+ECD    A       +C+N  G + C+
Sbjct: 1558 RCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603



 Score = 32.3 bits (72), Expect = 1.0
 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 4/43 (9%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
           C  G+E   V   C+D+DEC      C+ G +C N  GGY C+
Sbjct: 344 CPTGFE--RVNGSCEDVDEC-ATGGRCQHG-ECANTRGGYTCV 382


>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score =  144 bits (364), Expect = 1e-34
 Identities = 75/205 (36%), Positives = 108/205 (52%), Gaps = 12/205 (5%)

Query: 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPG 233
           C+   HNC     CIN+ GS+ C+C  GY    +Q  C   D C +  + C Q CVN PG
Sbjct: 242 CSTLEHNCA--HFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299

Query: 234 SFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNC 292
           SF CQC  G+ LA +   CV ++ C + N  C  +C N  GS++CQC++G+ L+ D+  C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359

Query: 293 EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCW 351
             ID C +S++ CQ++CVN    +SC C +G+ +    +TC+ IN C       E E C 
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-CV 418

Query: 352 NYHGGFRCYPRNPCQDPYILTPENR 376
           N    + C     C   Y L P  +
Sbjct: 419 NMEESYYC----RCHRGYTLDPNGK 439



 Score =  142 bits (359), Expect = 5e-34
 Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 15/228 (6%)

Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
           S+  +C  GY   S+   C+  D C    HNC  +Q+C+N+ GSF CQC  GY   + G+
Sbjct: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGK 316

Query: 211 QCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQC 268
           +CV +D C    + C   CVN  GS+ CQC  GF L  +  TC  I+ C +SN  C  +C
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376

Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-V 327
            N   S+ C C +G+ L+ D+  C  I+ C  +   C+++CVN    + C C +GY +  
Sbjct: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436

Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
             +TC  ++ C +  + C  +++C N    F C     C + +++  +
Sbjct: 437 NGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC----QCSEGFLINED 478



 Score =  136 bits (343), Expect = 4e-32
 Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 15/235 (6%)

Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK 207
           + ++ S+  QC  G+  + +   C  ID C +  H C+ +  C+N   S++C C  G+  
Sbjct: 336 VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTL 393

Query: 208 RGEQ--CVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ- 263
             ++  C  I+ C +  P C   CVN   S+YC+C  G+ L  N  TC  ++ C   +  
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG 453

Query: 264 CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
           C Q C N   SF+CQC++G+ ++ D   C  +D C  S + C+Y CVN    F+C CP+G
Sbjct: 454 CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG 513

Query: 324 YQVVRS--RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
           + V+RS  +TC  ++ C   +   E   C +    F C     C + YIL  + +
Sbjct: 514 H-VLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVC----QCFEGYILREDGK 562



 Score =  134 bits (336), Expect = 2e-31
 Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 42/399 (10%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
           QC  GY      ++C  +D C      C+   +CVN  G YLC       +     P ++
Sbjct: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFAL----NPDKK 357

Query: 88  TQP-----AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGR--NNFVIR 140
           T       A    G     V      +   L G            P+ +T R  N   + 
Sbjct: 358 TCTKIDYCASSNHGCQHECVNTDDSYSCHCLKG--------FTLNPDKKTCRRINYCALN 409

Query: 141 RNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFAC 199
           +   + + +    S+  +C  GY    +   C  +D C    H C  +Q+C+N   SF C
Sbjct: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC 467

Query: 200 QCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
           QC  G+   +  + C  +D C +  + C   CVN   SF CQC  G  L ++  TC  ++
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527

Query: 257 ECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
            C   +  C   C +   SF+CQC +GY L  D   C   D C+   + C++ CVN    
Sbjct: 528 SCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587

Query: 316 FSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
           ++C C +G+++    + C+  + C++T+   E  +C N    + C     C + ++L  +
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYIC----KCSEGFVLAED 642

Query: 375 NRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQI 413
            R         C++  +  +     I   +S+  + F++
Sbjct: 643 GR--------RCKKCTEGPIDLVFVIDGSKSLGEENFEV 673



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 45/132 (34%), Positives = 64/132 (48%), Gaps = 11/132 (8%)

Query: 262 NQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
           + CA  C NI GS++C+C QGY L+SD+  C   D C    + C+  CVN PG F C C 
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306

Query: 322 QGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC--- 377
            GY +    + C  ++ C + N   E E C N  G + C     C + + L P+ +    
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLC----QCHEGFALNPDKKTCTK 361

Query: 378 --VCPVSNAMCR 387
              C  SN  C+
Sbjct: 362 IDYCASSNHGCQ 373



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 67/276 (24%), Positives = 109/276 (39%), Gaps = 53/276 (19%)

Query: 26  YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
           Y +C  GY  DP  + C  +D C      C+    C+N    ++C  + ++  + NE  +
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLK 480

Query: 86  QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
                       T   V    ++  G       +  + A   PE        V+R +   
Sbjct: 481 ------------TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE------GHVLRSDGKT 522

Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
             ++ S       CA G    EH+                    C++   SF CQC  GY
Sbjct: 523 CAKLDS-------CALGDHGCEHS--------------------CVSSEDSFVCQCFEGY 555

Query: 206 --QKRGEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
             ++ G+ C   D C  I   C   CVN+  S+ C+C  GF+LA +   C   + C +++
Sbjct: 556 ILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615

Query: 263 Q-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
             C   C N   S+IC+C++G+ L+ D   C+   E
Sbjct: 616 HGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score =  144 bits (364), Expect = 1e-34
 Identities = 75/205 (36%), Positives = 108/205 (52%), Gaps = 12/205 (5%)

Query: 177 CTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPG 233
           C+   HNC     CIN+ GS+ C+C  GY    +Q  C   D C +  + C Q CVN PG
Sbjct: 242 CSTLEHNCA--HFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299

Query: 234 SFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNC 292
           SF CQC  G+ LA +   CV ++ C + N  C  +C N  GS++CQC++G+ L+ D+  C
Sbjct: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359

Query: 293 EDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTNECREDEMCW 351
             ID C +S++ CQ++CVN    +SC C +G+ +    +TC+ IN C       E E C 
Sbjct: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-CV 418

Query: 352 NYHGGFRCYPRNPCQDPYILTPENR 376
           N    + C     C   Y L P  +
Sbjct: 419 NMEESYYC----RCHRGYTLDPNGK 439



 Score =  142 bits (359), Expect = 5e-34
 Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 15/228 (6%)

Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY--QKRGE 210
           S+  +C  GY   S+   C+  D C    HNC  +Q+C+N+ GSF CQC  GY   + G+
Sbjct: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGK 316

Query: 211 QCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ-CAQQC 268
           +CV +D C    + C   CVN  GS+ CQC  GF L  +  TC  I+ C +SN  C  +C
Sbjct: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376

Query: 269 YNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-V 327
            N   S+ C C +G+ L+ D+  C  I+ C  +   C+++CVN    + C C +GY +  
Sbjct: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436

Query: 328 RSRTCQDINEC-ETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
             +TC  ++ C +  + C  +++C N    F C     C + +++  +
Sbjct: 437 NGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC----QCSEGFLINED 478



 Score =  136 bits (343), Expect = 4e-32
 Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 15/235 (6%)

Query: 149 IPSNPSHRIQCAAGYEQS-EHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK 207
           + ++ S+  QC  G+  + +   C  ID C +  H C+ +  C+N   S++C C  G+  
Sbjct: 336 VNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTL 393

Query: 208 RGEQ--CVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQ- 263
             ++  C  I+ C +  P C   CVN   S+YC+C  G+ L  N  TC  ++ C   +  
Sbjct: 394 NPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG 453

Query: 264 CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
           C Q C N   SF+CQC++G+ ++ D   C  +D C  S + C+Y CVN    F+C CP+G
Sbjct: 454 CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG 513

Query: 324 YQVVRS--RTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENR 376
           + V+RS  +TC  ++ C   +   E   C +    F C     C + YIL  + +
Sbjct: 514 H-VLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVC----QCFEGYILREDGK 562



 Score =  134 bits (336), Expect = 2e-31
 Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 42/399 (10%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
           QC  GY      ++C  +D C      C+   +CVN  G YLC       +     P ++
Sbjct: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFAL----NPDKK 357

Query: 88  TQP-----AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGR--NNFVIR 140
           T       A    G     V      +   L G            P+ +T R  N   + 
Sbjct: 358 TCTKIDYCASSNHGCQHECVNTDDSYSCHCLKG--------FTLNPDKKTCRRINYCALN 409

Query: 141 RNPADPQRIPSNPSHRIQCAAGYEQSEHN-VCQDIDECTAGTHNCRADQVCINLRGSFAC 199
           +   + + +    S+  +C  GY    +   C  +D C    H C  +Q+C+N   SF C
Sbjct: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC 467

Query: 200 QCPPGY--QKRGEQCVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN 256
           QC  G+   +  + C  +D C +  + C   CVN   SF CQC  G  L ++  TC  ++
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527

Query: 257 ECDASNQ-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGK 315
            C   +  C   C +   SF+CQC +GY L  D   C   D C+   + C++ CVN    
Sbjct: 528 SCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDS 587

Query: 316 FSCMCPQGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPE 374
           ++C C +G+++    + C+  + C++T+   E  +C N    + C     C + ++L  +
Sbjct: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYIC----KCSEGFVLAED 642

Query: 375 NRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQI 413
            R         C++  +  +     I   +S+  + F++
Sbjct: 643 GR--------RCKKCTEGPIDLVFVIDGSKSLGEENFEV 673



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 45/132 (34%), Positives = 64/132 (48%), Gaps = 11/132 (8%)

Query: 262 NQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
           + CA  C NI GS++C+C QGY L+SD+  C   D C    + C+  CVN PG F C C 
Sbjct: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306

Query: 322 QGYQVVR-SRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC--- 377
            GY +    + C  ++ C + N   E E C N  G + C     C + + L P+ +    
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLC----QCHEGFALNPDKKTCTK 361

Query: 378 --VCPVSNAMCR 387
              C  SN  C+
Sbjct: 362 IDYCASSNHGCQ 373



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 67/276 (24%), Positives = 109/276 (39%), Gaps = 53/276 (19%)

Query: 26  YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQ 85
           Y +C  GY  DP  + C  +D C      C+    C+N    ++C  + ++  + NE  +
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLK 480

Query: 86  QETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPAD 145
                       T   V    ++  G       +  + A   PE        V+R +   
Sbjct: 481 ------------TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE------GHVLRSDGKT 522

Query: 146 PQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGY 205
             ++ S       CA G    EH+                    C++   SF CQC  GY
Sbjct: 523 CAKLDS-------CALGDHGCEHS--------------------CVSSEDSFVCQCFEGY 555

Query: 206 --QKRGEQCVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
             ++ G+ C   D C  I   C   CVN+  S+ C+C  GF+LA +   C   + C +++
Sbjct: 556 ILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615

Query: 263 Q-CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE 297
             C   C N   S+IC+C++G+ L+ D   C+   E
Sbjct: 616 HGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  137 bits (345), Expect = 2e-32
 Identities = 75/226 (33%), Positives = 112/226 (49%), Gaps = 18/226 (7%)

Query: 173 DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPY---CHQRCV 229
           D+DEC+ GT +C  D +C N   S+ C C PGY+  G+QC DIDEC    Y   C   C+
Sbjct: 33  DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNGGCVHECI 92

Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSD 288
           N PG++ C C  GF LA + + C+D++EC D +  C Q C N +GS+ CQC+ G+ LS +
Sbjct: 93  NIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDN 152

Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSRTCQDINECETTNE 343
           +  C     +   C    + C + C   P G  +C C  G+ + +++    +        
Sbjct: 153 QHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGG 212

Query: 344 CREDEMCWNYHGGFRCYPRNPCQDPYILTPENR-CV--CPVSNAMC 386
           C+    C +   G  C     C   Y L  + R C+  C V+N  C
Sbjct: 213 CQHS--CEDTDTGPTC----GCHQKYALHSDGRTCIETCAVNNGGC 252



 Score =  133 bits (335), Expect = 3e-31
 Identities = 91/336 (27%), Positives = 142/336 (42%), Gaps = 15/336 (4%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGM--KCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
           C  GY+ +   +QC+DIDEC+   D   GG   +C+N  G Y C      ++ ++     
Sbjct: 61  CKPGYKGEG--KQCEDIDECE--NDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116

Query: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
           +    +  +G    +   +  +       G F++            G N        A  
Sbjct: 117 DVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI 176

Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
            R          C  G++ +++     +  C  G   C+    C +      C C   Y 
Sbjct: 177 CRETPKGGVACDCRPGFDLAQNQKDCTL-TCNYGNGGCQ--HSCEDTDTGPTCGCHQKYA 233

Query: 207 KRGEQCVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN-QC 264
              +    I+ C +    C + C +T     C C  GF L  +  TC DINEC  +N  C
Sbjct: 234 LHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC 293

Query: 265 AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
              C N +GSF C C +GY+L +D   C+DIDEC +    C + C+N PG F C+C +GY
Sbjct: 294 DHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCDHICINSPGSFQCLCHRGY 352

Query: 325 QVVRSRTCQDINECETTN-ECREDEMCWNYHGGFRC 359
            +  +  C D++EC  +N  C  D+ C N  G + C
Sbjct: 353 ILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYEC 386



 Score =  115 bits (289), Expect = 7e-26
 Identities = 94/321 (29%), Positives = 134/321 (41%), Gaps = 63/321 (19%)

Query: 106 SMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQ 165
           ++ T G L GG  +  +  V   E   G ++  I    A  Q  P   S++  C  GY+ 
Sbjct: 15  ALGTRGRLAGGSGLPGSVDV--DECSEGTDDCHI---DAICQNTPK--SYKCLCKPGYK- 66

Query: 166 SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDEC-TIPP 222
            E   C+DIDEC    +N      CIN+ G++ C C  G+     G  C+D+DEC     
Sbjct: 67  GEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNG 126

Query: 223 YCHQRCVNTPGSFYCQCSPGFQLAANNYTCV-----DINECDASNQCAQQCYNI-LGSFI 276
            C Q CVN  GS+ CQC  GF L+ N +TC+      +N  +  + CA  C     G   
Sbjct: 127 GCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA 186

Query: 277 CQCNQGYELSSDRL---------------NCED----------------------IDECR 299
           C C  G++L+ ++                +CED                      I+ C 
Sbjct: 187 CDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCA 246

Query: 300 TSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTN-ECREDEMCWNYHGGF 357
            ++  C   C +      C CP G+ +    +TC+DINEC   N  C  D  C N  G F
Sbjct: 247 VNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGC--DHFCRNTVGSF 304

Query: 358 RCYPRNPCQDPY-ILTPENRC 377
            C     C+  Y +LT E  C
Sbjct: 305 EC----GCRKGYKLLTDERTC 321



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 4/72 (5%)

Query: 149 IPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQK- 207
           I S  S +  C  GY       C D+DEC+    +C  DQ C+N +GS+ C CPPG +  
Sbjct: 338 INSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSC--DQGCVNTKGSYECVCPPGRRLH 395

Query: 208 -RGEQCVDIDEC 218
             G+ CV+  +C
Sbjct: 396 WNGKDCVETGKC 407


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  135 bits (339), Expect = 1e-31
 Identities = 77/232 (33%), Positives = 115/232 (49%), Gaps = 29/232 (12%)

Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPY--CHQRCV 229
           QD+DEC  GT NC  D +C N   S+ C C  GY   G+ C D+DEC       C   CV
Sbjct: 28  QDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCV 87

Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQCYNILGSFICQCNQGYELSSD 288
           N PG++ C C  GF LA + + C+D++EC + +  C Q C N++GS+ C C +G+ LS +
Sbjct: 88  NIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDN 147

Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSR-----TCQDIN-E 337
           +  C    E+   C   ++ C + C   P G  +C C  G+++ +++     TC   N  
Sbjct: 148 QHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGG 207

Query: 338 CETTNECREDEMCWNYHGGFRCYPRNPCQDPYIL-TPENRCV--CPVSNAMC 386
           C+ T  C + E            PR  C   ++L T    C+  C V+N  C
Sbjct: 208 CQHT--CDDTEQ----------GPRCGCHIKFVLHTDGKTCIETCAVNNGGC 247



 Score =  129 bits (325), Expect = 5e-30
 Identities = 91/296 (30%), Positives = 124/296 (41%), Gaps = 64/296 (21%)

Query: 145 DPQRIPSNPSHRIQCAAGYEQSE--HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
           D   IP N  +R  C  G+  +   HN C D+DEC  G   C+  Q C+N+ GS+ C C 
Sbjct: 85  DCVNIPGN--YRCTCYDGFHLAHDGHN-CLDVDECAEGNGGCQ--QSCVNMMGSYECHCR 139

Query: 203 PGYQKRGEQ--CVDIDE----CTIPPY-CHQRCVNTP-GSFYCQCSPGFQLAANN----- 249
            G+     Q  C+   E    C    + C   C  TP G   C+C PGF+L  N      
Sbjct: 140 EGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKL 199

Query: 250 ----------YTCVD----------------------INECDASNQ-CAQQCYNILGSFI 276
                     +TC D                      I  C  +N  C  +C++      
Sbjct: 200 TCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVH 259

Query: 277 CQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQ-VVRSRTCQDI 335
           C C  G+ L  DR  C+DIDECR ++  C + C N  G F C C +GY+ ++  R CQDI
Sbjct: 260 CTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 319

Query: 336 NECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC----VCPVSNAMCR 387
           +EC     C  D +C N  G F+C     C   Y+L     C     C ++   CR
Sbjct: 320 DECSFDRTC--DHICVNTPGSFQCL----CHRGYLLYGITHCGDVDECSINRGGCR 369



 Score =  124 bits (312), Expect = 1e-28
 Identities = 86/303 (28%), Positives = 126/303 (41%), Gaps = 21/303 (6%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C DG+        C D+DEC      C+    CVN  G Y C  +    + +N+    + 
Sbjct: 97  CYDGFHLAHDGHNCLDVDECAEGNGGCQ--QSCVNMMGSYECHCREGFFLSDNQHTCIQ- 153

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP-- 146
           +P EG +        A     +   P GG         G E+   + +  +  N  +   
Sbjct: 154 RPEEGMNCMNKNHGCAHICRET---PKGGIACECRP--GFELTKNQRDCKLTCNYGNGGC 208

Query: 147 QRIPSNPSHRIQCAAGYE---QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
           Q    +     +C    +    ++   C  I+ C      C  D  C +      C CP 
Sbjct: 209 QHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGC--DSKCHDAATGVHCTCPV 264

Query: 204 GYQKRGEQ--CVDIDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDA 260
           G+  + ++  C DIDEC +    C   C NT GSF C C  G++L  N   C DI+EC  
Sbjct: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF 324

Query: 261 SNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMC 320
              C   C N  GSF C C++GY L     +C D+DEC  +   C++ C+N PG + C C
Sbjct: 325 DRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTC 383

Query: 321 PQG 323
           P G
Sbjct: 384 PAG 386



 Score =  120 bits (300), Expect = 4e-27
 Identities = 97/339 (28%), Positives = 139/339 (41%), Gaps = 22/339 (6%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDA-CKGGMKCVNHYGGYLCLPKTA-QIIVNNEQPQQ 86
           C  GY  D   + CKD+DEC+   +A C     CVN  G Y C       +  +      
Sbjct: 57  CKSGYTGDG--KHCKDVDECEREDNAGCV--HDCVNIPGNYRCTCYDGFHLAHDGHNCLD 112

Query: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVAS---AAAVAGPEMQTGRNNFVIRRNP 143
             + AEG  G     V  + M +       GF  S      +  PE   G N        
Sbjct: 113 VDECAEGNGGCQQSCV--NMMGSYECHCREGFFLSDNQHTCIQRPE--EGMNCMNKNHGC 168

Query: 144 ADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPP 203
           A   R         +C  G+E +++     +  C  G   C+    C +      C C  
Sbjct: 169 AHICRETPKGGIACECRPGFELTKNQRDCKL-TCNYGNGGCQ--HTCDDTEQGPRCGCHI 225

Query: 204 GYQKRGEQCVDIDECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
            +    +    I+ C +    C  +C +     +C C  GF L  +  TC DI+EC  +N
Sbjct: 226 KFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNN 285

Query: 263 -QCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
             C   C N +GSF C C +GY+L  +  NC+DIDEC +    C + CVN PG F C+C 
Sbjct: 286 GGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCH 344

Query: 322 QGYQVVRSRTCQDINECE-TTNECREDEMCWNYHGGFRC 359
           +GY +     C D++EC      CR    C N  G ++C
Sbjct: 345 RGYLLYGITHCGDVDECSINRGGCRFG--CINTPGSYQC 381



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 62/264 (23%), Positives = 89/264 (33%), Gaps = 73/264 (27%)

Query: 23  TITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNE 82
           T  +  C  G+   P R+ CKDIDEC +    C     C N  G + C  K    ++ NE
Sbjct: 256 TGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGC--DHICRNTVGSFECSCKKGYKLLINE 313

Query: 83  QPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN 142
           +  Q+    E +   T   +  ++       PG                           
Sbjct: 314 RNCQDID--ECSFDRTCDHICVNT-------PG--------------------------- 337

Query: 143 PADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
                      S +  C  GY       C D+DEC+     CR    CIN  GS+ C CP
Sbjct: 338 -----------SFQCLCHRGYLLYGITHCGDVDECSINRGGCRFG--CINTPGSYQCTCP 384

Query: 203 PGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASN 262
            G   +G    +  +CT P               CQ SPG   A      +  N     +
Sbjct: 385 AG---QGRLHWNGKDCTEP-------------LKCQGSPGASKA-----MLSCNRSGKKD 423

Query: 263 QCAQQCYNILGSFICQCNQGYELS 286
            CA  C +    F+ +   G+ +S
Sbjct: 424 TCALTCPS-RARFLPESENGFTVS 446



 Score = 36.2 bits (82), Expect = 0.070
 Identities = 29/115 (25%), Positives = 47/115 (40%), Gaps = 9/115 (7%)

Query: 42  CKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVN-NEQPQQETQPAEGTSGATTG 100
           C D+DEC I    C+ G  C+N  G Y C     Q  ++ N +   E    +G+ GA+  
Sbjct: 355 CGDVDECSINRGGCRFG--CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKA 412

Query: 101 VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH 155
           +++ +    SG          + A   PE +   N F +      P+  P+   H
Sbjct: 413 MLSCN---RSGKKDTCALTCPSRARFLPESE---NGFTVSCGTPSPRAAPARAGH 461


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  135 bits (339), Expect = 1e-31
 Identities = 68/192 (35%), Positives = 96/192 (50%), Gaps = 12/192 (6%)

Query: 156 RIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQC 212
           R +C  GY+  ++   C+D+DEC AG   C     C+N +GSF C C  GY+    G QC
Sbjct: 267 RCECHVGYQLAADGKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYELGADGRQC 324

Query: 213 VDIDECTIPPY------CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQ 266
             I+   +         C   C +T     C C  G++L  +  TC+D+++C  S  C Q
Sbjct: 325 YRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQ 384

Query: 267 QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV 326
            C N  G + C C  GY LS+D   CED+DEC +S   C++ C N  G F C C  GY++
Sbjct: 385 VCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRL 444

Query: 327 VRSRT-CQDINE 337
              R  C  + E
Sbjct: 445 HEDRRGCSPLEE 456



 Score =  124 bits (312), Expect = 1e-28
 Identities = 71/217 (32%), Positives = 107/217 (49%), Gaps = 14/217 (6%)

Query: 154 SHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GE 210
           S+  +C  G+   ++   C  I+ C  G   C+   V + +     CQC PG+Q +  G 
Sbjct: 182 SYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTIT-RHRCQCRPGFQLQEDGR 240

Query: 211 QCVDIDECTIPP-YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDAS-NQCAQQC 268
            CV    C      C  RC    G   C+C  G+QLAA+   C D++EC A   QCA  C
Sbjct: 241 HCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGC 300

Query: 269 YNILGSFICQCNQGYELSSD-----RLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQG 323
            N  GSF C C+ GYEL +D     R+  E ++ C  ++  C + C +      C CP+G
Sbjct: 301 LNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG 360

Query: 324 YQV-VRSRTCQDINECETTNECREDEMCWNYHGGFRC 359
           Y++    RTC D+++C  +  C+  ++C N  GG+ C
Sbjct: 361 YELDTDQRTCIDVDDCADSPCCQ--QVCTNNPGGYEC 395



 Score =  122 bits (307), Expect = 6e-28
 Identities = 70/204 (34%), Positives = 100/204 (49%), Gaps = 20/204 (9%)

Query: 151 SNPSHRIQCAAGYEQSEHNVCQ-DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG 209
           + P H   C  G++      CQ D+DEC   THN      C+N  GS+ C+C PG++   
Sbjct: 144 AQPCH---CPPGFQGPR---CQYDVDECR--THNGGCQHRCVNTPGSYLCECKPGFRLHT 195

Query: 210 EQ--CVDIDECTIPPY-CHQRCVN-TPGSFYCQCSPGFQLAANNYTCVDINECDASN-QC 264
           +   C+ I+ C +    C   CV  T     CQC PGFQL  +   CV  + C   N  C
Sbjct: 196 DSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSC 255

Query: 265 AQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
             +C  + G   C+C+ GY+L++D   CED+DEC      C + C+N  G F C+C  GY
Sbjct: 256 MHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGY 315

Query: 325 QV-VRSRTC-----QDINECETTN 342
           ++    R C     + +N CE  N
Sbjct: 316 ELGADGRQCYRIEMEIVNSCEANN 339



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 81/365 (22%), Positives = 125/365 (34%), Gaps = 77/365 (21%)

Query: 28  QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
           +C  GY+     + C+D+DEC      C  G  C+N  G + C+      +         
Sbjct: 269 ECHVGYQLAADGKACEDVDECAAGLAQCAHG--CLNTQGSFKCVCHAGYEL--------- 317

Query: 88  TQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQ 147
                G  G     +    + +     GG     +   AGP                   
Sbjct: 318 -----GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGP------------------- 353

Query: 148 RIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
                      C  GYE  ++   C D+D+C A +  C+  QVC N  G + C C  GY+
Sbjct: 354 --------LCTCPRGYELDTDQRTCIDVDDC-ADSPCCQ--QVCTNNPGGYECGCYAGYR 402

Query: 207 KRGEQC--VDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE----CD 259
              + C   D+DEC +    C   C N  GSF C C  G++L  +   C  + E     D
Sbjct: 403 LSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 462

Query: 260 ASNQCAQQCYNI--LGSFICQCNQGYELSSDRLNCEDIDE-CRTSSYLCQYQCVNEP--- 313
                 +   +I  L   + Q  Q  ++ +D    E   E   T  ++C           
Sbjct: 463 GELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSL 522

Query: 314 -------------GKFSCMCPQGYQ-VVRSRTCQDI---NECETTNECREDEMCWNYHGG 356
                        G   C CP+G+  ++ + TC        C  +  C+    C +  G 
Sbjct: 523 TCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGA 582

Query: 357 FRCYP 361
            RC P
Sbjct: 583 CRCPP 587



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 70/277 (25%), Positives = 97/277 (35%), Gaps = 61/277 (22%)

Query: 154  SHRIQCAAGYEQSEHNVCQDIDE---CTAGTHNCRADQVCINLRGSFACQCPPGYQ-KRG 209
            SH   C+AG     H  C  I     C AG    R +Q C   +G F   C    Q + G
Sbjct: 870  SHPCNCSAG-----HGSCDAISGLCLCEAGYVGPRCEQQCP--QGHFGPGCEQRCQCQHG 922

Query: 210  EQCVDID-ECTIPP-----YCHQRCVNTPGSFY-------CQCSPGFQLAANNYTCVD-- 254
              C  +   CT P      +C   C   P  F+       C C+ G    A N +C+   
Sbjct: 923  AACDHVSGACTCPAGWRGTFCEHAC---PAGFFGLDCRSACNCTAGAACDAVNGSCLCPA 979

Query: 255  -------INECDA---SNQCAQQCYNILGSFI------CQCNQGYELSSDRLNCEDI--- 295
                      C A    + C+Q C    G+        C C  G+   S    C      
Sbjct: 980  GRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYG 1039

Query: 296  DECRTSSYLCQYQCVNEPGKFSCMCPQGYQ-VVRSRTC--QDINE-CETTNECREDEMCW 351
            D CR S  LCQ     +P    C CP+G+  +   + C  +D+   C  +  C    +C 
Sbjct: 1040 DNCRHSC-LCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCD 1098

Query: 352  NYHGGFRC---YPRNPCQDPYIL-----TPENRCVCP 380
             + G   C   +  + CQ P +          RC CP
Sbjct: 1099 PHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCP 1135



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 56/234 (23%), Positives = 82/234 (35%), Gaps = 44/234 (18%)

Query: 156  RIQCAAGYEQSEHNVCQD------IDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--- 206
            R  C AG+   +   CQ         E  A   +C     C ++ G  AC+CPPG+    
Sbjct: 1103 RCLCPAGWTGDK---CQSPCLRGWFGEACAQRCSCPPGAACHHVTG--ACRCPPGFTGSG 1157

Query: 207  --------KRGEQCVDIDECT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE 257
                      GE C  + +C    P CH      P +  C C+ G+   +    C     
Sbjct: 1158 CEQACPPGSFGEDCAQMCQCPGENPACH------PATGTCSCAAGYHGPSCQQRCPPGR- 1210

Query: 258  CDASNQCAQQCYNILG------SFICQCNQGYELSSDRLNCEDIDECRTSSYL--CQYQC 309
                  C Q C  + G      +  C+C  G+  +   L C         +++  C    
Sbjct: 1211 --YGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGA 1268

Query: 310  VNEPGKFSCMCPQGYQVVR-SRTCQDIN---ECETTNECREDEMCWNYHGGFRC 359
              +P   +C+CP G   VR  R C        CE T  CR   +C   +G   C
Sbjct: 1269 ACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSC 1322



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 58/237 (24%), Positives = 80/237 (33%), Gaps = 54/237 (22%)

Query: 158 QCAAGYEQSEHNVCQDIDECTAGTH--NCRAD-----QVCINLRGSFACQCPPGYQKRGE 210
           +C AG++  +        EC  GT   NC +        C  + G   C+CPPG  + GE
Sbjct: 717 RCPAGFQGEDCG-----QECPVGTFGVNCSSSCSCGGAPCHGVTGQ--CRCPPG--RTGE 767

Query: 211 QC-VDIDE------CT-IPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI------- 255
            C  D  E      C  I P C       P +  C C PGF        C D+       
Sbjct: 768 DCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFV----GSRCQDVCPAGWYG 823

Query: 256 NECDASNQCAQ--QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEP 313
             C     CA    C+   G   C C  G+       +C+   +       C + C    
Sbjct: 824 PSCQTRCSCANDGHCHPATGH--CSCAPGW----TGFSCQRACDTGHWGPDCSHPCNCSA 877

Query: 314 GKFS-------CMCPQGYQVVR-SRTCQDIN---ECETTNECREDEMCWNYHGGFRC 359
           G  S       C+C  GY   R  + C   +    CE   +C+    C +  G   C
Sbjct: 878 GHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTC 934



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 48/191 (25%), Positives = 67/191 (35%), Gaps = 46/191 (24%)

Query: 157  IQCAAGYEQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFAC-----------QCPPG 204
            ++C  G  Q+   V C+        T +CR   +C    GS +C            CPPG
Sbjct: 1286 VRCERGCPQNRFGVGCEH-------TCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPG 1338

Query: 205  YQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTC-VDINECDASNQ 263
              + G  C    EC+    CH      P +  C+C PGF   A  + C    +       
Sbjct: 1339 --RYGAACHL--ECS----CHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGL 1390

Query: 264  CAQQ----CYNILGSFICQ-------CNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNE 312
            C  Q    C  I G  +C        C +G E  S    C    +C   +      C  +
Sbjct: 1391 CWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGA-----PC--D 1443

Query: 313  PGKFSCMCPQG 323
            P    C+CP G
Sbjct: 1444 PVTGLCLCPPG 1454



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 55/239 (23%), Positives = 81/239 (33%), Gaps = 37/239 (15%)

Query: 183 NCRADQVCINLRGSFACQCPPGYQKRGEQCVD-IDECTIPPYCHQRC-VNTPGSFY---- 236
           +C+    C ++ G  AC+CPPG    G  C D   +     +C ++C     G  +    
Sbjct: 569 SCQNGGTCDSVTG--ACRCPPGVS--GTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYG 624

Query: 237 -CQCSPGFQLAANNYTCVD-------INECDASNQCAQQCYNILGSFICQCNQGYELSSD 288
            C C PG      + TC           EC       Q C    GS  C C  G+     
Sbjct: 625 ACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGS--CSCKAGFRGERC 682

Query: 289 RLNCE----DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQ----DINECE 339
           +  CE         +  +      C +  G+    CP G+Q     + C      +N C 
Sbjct: 683 QAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVN-CS 741

Query: 340 TTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRC------VCPVSNAMCRELPQS 392
           ++  C     C    G  RC P    +D     PE R       +CP      R  P++
Sbjct: 742 SSCSC-GGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPET 799


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  134 bits (336), Expect = 2e-31
 Identities = 61/167 (36%), Positives = 93/167 (55%), Gaps = 8/167 (4%)

Query: 172 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDEC--TIPPYCHQRCV 229
           +D+DEC  G  +C AD +C N   S+ C C PGYQ  G QC DIDEC   +   C   C+
Sbjct: 44  EDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCL 103

Query: 230 NTPGSFYCQCSPGFQLAANNYTCVDINECDASN-QCAQQCYNILGSFICQCNQGYELSSD 288
           N PG++ C C  GF LA + + C+D++EC  +N  C   C N++GS+ C C +G+ LS +
Sbjct: 104 NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN 163

Query: 289 RLNC----EDIDECRTSSYLCQYQCVNEP-GKFSCMCPQGYQVVRSR 330
           +  C    E+   C    + C + C   P G  +C C  G+++ +++
Sbjct: 164 QHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQ 210



 Score =  119 bits (297), Expect = 8e-27
 Identities = 90/366 (24%), Positives = 144/366 (39%), Gaps = 46/366 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGM--KCVNHYGGYLCLPKTAQIIVNNEQPQQ 86
           C  GY+ +   +QC+DIDEC    +   GG    C+N  G Y C      ++ ++     
Sbjct: 73  CKPGYQGEG--RQCEDIDECG---NELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCL 127

Query: 87  ETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADP 146
           +       +G           +       G F++          + G +        +  
Sbjct: 128 DVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHI 187

Query: 147 QRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ 206
            +     S   +C  G+E ++ N    I  C  G   C+    C +      C C P Y+
Sbjct: 188 CKEAPRGSVACECRPGFELAK-NQRDCILTCNHGNGGCQ--HSCDDTADGPECSCHPQYK 244

Query: 207 KR--GEQCVDIDECTIPPY-----------------------------CHQRCVNTPGSF 235
               G  C++ ++  +                                C + C +T    
Sbjct: 245 MHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGV 304

Query: 236 YCQCSPGFQLAANNYTCVDINECDASN-QCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
           +C C  GF L  +  TC DI+EC   N  C   C NI+GSF C C +G++L +D  +C+D
Sbjct: 305 HCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQD 364

Query: 295 IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTN-ECREDEMCWNY 353
           +DEC +    C + C+N PG F+C C +GY +     C D NEC   N  C+  ++C N 
Sbjct: 365 VDEC-SLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQ--QVCVNT 421

Query: 354 HGGFRC 359
            G + C
Sbjct: 422 VGSYEC 427



 Score =  115 bits (289), Expect = 7e-26
 Identities = 97/370 (26%), Positives = 138/370 (37%), Gaps = 45/370 (12%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQET 88
           C DG+        C D+DEC      C+    CVN  G Y C  K    + +N    Q T
Sbjct: 113 CFDGFMLAHDGHNCLDVDECLENNGGCQH--TCVNVMGSYECCCKEGFFLSDN----QHT 166

Query: 89  QPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRN------ 142
                  G +               P G          G E+   + + ++  N      
Sbjct: 167 CIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRP--GFELAKNQRDCILTCNHGNGGC 224

Query: 143 ------PADPQRIPSNPSHRIQCAAG---------YEQSEHNVCQDIDEC---------- 177
                  AD      +P +++               E +E N    +D            
Sbjct: 225 QHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLME 284

Query: 178 TAGTHNCRADQVCINLRGSFACQCPPGY--QKRGEQCVDIDEC-TIPPYCHQRCVNTPGS 234
           T   +N   D+ C +      C CP G+  Q  G+ C DIDEC T    C   C N  GS
Sbjct: 285 TCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344

Query: 235 FYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCED 294
           F C C  GF+L  +  +C D++EC     C   C N  G+F C CN+GY L     +C D
Sbjct: 345 FDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYG-FTHCGD 403

Query: 295 IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINE-CETTNECREDEMCWN 352
            +EC  ++  CQ  CVN  G + C C  GY++    + C ++     T+   R    C  
Sbjct: 404 TNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGK 463

Query: 353 YHGGFRCYPR 362
             GG  C+ R
Sbjct: 464 SGGGDGCFLR 473



 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 21/206 (10%)

Query: 154 SHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQ 211
           S++  C  GY Q E   C+DIDEC     N      C+N+ G++ C C  G+     G  
Sbjct: 68  SYKCSCKPGY-QGEGRQCEDIDEC-GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHN 125

Query: 212 CVDIDEC-TIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINE-----CDASNQCA 265
           C+D+DEC      C   CVN  GS+ C C  GF L+ N +TC+  +E      +  + C+
Sbjct: 126 CLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCS 185

Query: 266 QQCYNI-LGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGY 324
             C     GS  C+C  G+EL+ ++ +C  I  C   +  CQ+ C +      C C   Y
Sbjct: 186 HICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPECSCHPQY 243

Query: 325 Q--------VVRSRTCQDINECETTN 342
           +        + R  T  ++ E  TT+
Sbjct: 244 KMHTDGRSCLEREDTVLEVTESNTTS 269



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 49/128 (38%), Positives = 67/128 (52%), Gaps = 7/128 (5%)

Query: 202 PPGYQKRGEQCVDIDECTIP-PYCHQR--CVNTPGSFYCQCSPGFQLAANNYTCVDINEC 258
           PPG  +      D+DEC      CH    C NTP S+ C C PG+Q       C DI+EC
Sbjct: 33  PPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQ--GEGRQCEDIDEC 90

Query: 259 --DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKF 316
             + +  C   C NI G++ C C  G+ L+ D  NC D+DEC  ++  CQ+ CVN  G +
Sbjct: 91  GNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSY 150

Query: 317 SCMCPQGY 324
            C C +G+
Sbjct: 151 ECCCKEGF 158



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 79/275 (28%), Positives = 114/275 (41%), Gaps = 55/275 (20%)

Query: 145 DPQRIPSNPSHRIQCAAGYEQSE--HNVCQDIDECTAGTHNCRADQVCINLRGSFACQCP 202
           D   IP N  +R  C  G+  +   HN C D+DEC      C+    C+N+ GS+ C C 
Sbjct: 101 DCLNIPGN--YRCTCFDGFMLAHDGHN-CLDVDECLENNGGCQ--HTCVNVMGSYECCCK 155

Query: 203 PGYQKRGEQ--CVDIDE----CTIPPY-CHQRCVNTP-GSFYCQCSPGFQLAANNYTCVD 254
            G+     Q  C+   E    C    + C   C   P GS  C+C PGF+LA N   C  
Sbjct: 156 EGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC-- 213

Query: 255 INECDASN-QCAQQCYNILGSFICQCNQGYELSSDRLNC---ED---------------- 294
           I  C+  N  C   C +      C C+  Y++ +D  +C   ED                
Sbjct: 214 ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDG 273

Query: 295 ---------IDECRTSSYLCQYQCVNEPGKFSCMCPQGYQV-VRSRTCQDINECETTN-E 343
                    ++ C  ++  C   C +      C CP G+ + +  +TC+DI+EC+T N  
Sbjct: 274 DKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGG 333

Query: 344 CREDEMCWNYHGGFRCYPRNPCQDPY-ILTPENRC 377
           C  D  C N  G F C     C+  + +LT E  C
Sbjct: 334 C--DHFCKNIVGSFDC----GCKKGFKLLTDEKSC 362



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 52/138 (37%), Positives = 71/138 (51%), Gaps = 11/138 (7%)

Query: 159 CAAGYEQ-SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRG-EQCVDID 216
           C  G++  ++   CQD+DEC+    +   D  CIN  G+FAC C  GY   G   C D +
Sbjct: 349 CKKGFKLLTDEKSCQDVDECSL---DRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTN 405

Query: 217 ECTI-PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDIN---ECDASNQCAQQCYNIL 272
           EC+I    C Q CVNT GS+ CQC PG++L  N   CV++        S + +  C    
Sbjct: 406 ECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSG 465

Query: 273 GSFIC--QCNQGYELSSD 288
           G   C  +C+ G  LSSD
Sbjct: 466 GGDGCFLRCHSGIHLSSD 483


>gi|189491645 fibulin 7 isoform 1 [Homo sapiens]
          Length = 439

 Score =  134 bits (336), Expect = 2e-31
 Identities = 100/366 (27%), Positives = 155/366 (42%), Gaps = 67/366 (18%)

Query: 153 PSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC 212
           PS  +    G    E   C+ I EC++    C+    C+     + C CPPG  + G +C
Sbjct: 116 PSSVVCLPNGTWTGEQPHCRGISECSS--QPCQNGGTCVEGVNQYRCICPPG--RTGNRC 171

Query: 213 VDIDECTIPPYC---------HQRCVNTPGSFYCQCSPGFQL--AANNYTCVDINECDAS 261
               +   P              RC     + +C C  GF L  AA +  C D+NEC+  
Sbjct: 172 QHQAQTAAPEGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELY 231

Query: 262 NQ------CAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEP 313
            Q      C   C N  GS+ C C  GY   +D  +CED+DEC     +C     C+N  
Sbjct: 232 GQEGRPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTG 291

Query: 314 GKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNY--HGGFRCYPRNPCQDPYIL 371
           G F C+ P                     EC E     +Y     F+C  RNP       
Sbjct: 292 GSFQCVSP---------------------ECPEGSGNVSYVKTSPFQC-ERNP------- 322

Query: 372 TPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA----NTINTFR 427
                  CP+ +  CR LP++I + Y+S+ S+   P  +F++   +       N++  F 
Sbjct: 323 -------CPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATASAPGRAGPNSLR-FG 374

Query: 428 IKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTII 487
           I  GN  G F ++++   +  L+LV++L GP+   VD++M       +F+ + V ++TI 
Sbjct: 375 IVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLD-RSFQANHVSKVTIF 433

Query: 488 VGPFSF 493
           V P+ F
Sbjct: 434 VSPYDF 439



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 14/43 (32%), Positives = 21/43 (48%)

Query: 29  CTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL 71
           C  GY      + C+D+DEC  +   C  G  C+N  G + C+
Sbjct: 255 CPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCV 297


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,548,018
Number of Sequences: 37866
Number of extensions: 1120259
Number of successful extensions: 8042
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 2690
Number of HSP's gapped (non-prelim): 1942
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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