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Search of human proteins with 85362735
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|85362735 nuclear receptor subfamily 1, group H, member 2
[Homo sapiens]
(461 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 936 0.0
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 538 e-153
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 537 e-153
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 244 1e-64
gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 231 1e-60
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 206 5e-53
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 202 7e-52
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 199 6e-51
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 197 1e-50
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 197 1e-50
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 191 1e-48
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 185 9e-47
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 180 3e-45
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 175 7e-44
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 175 9e-44
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 170 3e-42
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 165 9e-41
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 164 2e-40
gi|11415052 retinoid X receptor, beta [Homo sapiens] 160 2e-39
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 158 9e-39
gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 154 1e-37
gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 154 2e-37
gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 154 2e-37
gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 154 2e-37
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 152 8e-37
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 936 bits (2418), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW 60
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
Sbjct: 1 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW 60
Query: 61 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
Sbjct: 61 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS
Sbjct: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK
Sbjct: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
Query: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300
RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ
Sbjct: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300
Query: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360
IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM
Sbjct: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360
Query: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420
RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR
Sbjct: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420
Query: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 538 bits (1387), Expect = e-153
Identities = 287/461 (62%), Positives = 339/461 (73%), Gaps = 29/461 (6%)
Query: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62
P S+++ PG A S + +EE P G V G + A
Sbjct: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71
Query: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G
Sbjct: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130
Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ +
Sbjct: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189
Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
S P ++S P P QL+ Q MI++LVAAQ QCN+
Sbjct: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226
Query: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300
RSFSD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQ
Sbjct: 227 RSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQ 286
Query: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360
IALLK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM
Sbjct: 287 IALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAM 346
Query: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420
L L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPR
Sbjct: 347 NELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPR 406
Query: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 407 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 447
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 537 bits (1383), Expect = e-153
Identities = 273/398 (68%), Positives = 319/398 (80%), Gaps = 25/398 (6%)
Query: 64 DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY 123
+P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G Y
Sbjct: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA--HY 87
Query: 124 ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQ 183
C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ + S
Sbjct: 88 ICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSL 147
Query: 184 SPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSF 243
P ++S P P QL+ Q MI++LVAAQ QCN+RSF
Sbjct: 148 PP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNRRSF 184
Query: 244 SDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIAL 303
SD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQIAL
Sbjct: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244
Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363
LK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L
Sbjct: 245 LKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNEL 304
Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423
L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLM
Sbjct: 305 QLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLM 364
Query: 424 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 365 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 244 bits (623), Expect = 1e-64
Identities = 142/390 (36%), Positives = 215/390 (55%), Gaps = 28/390 (7%)
Query: 70 ERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGG 129
++ R A ++ G ELC VCGD+ASG+HYN L+CEGCKGFFRRS+ + Y C+ GG
Sbjct: 110 KKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAV--YKCKNGG 167
Query: 130 TCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQ 189
C MD +MRRKCQ+CRLRKCKE GM +C+L+E Q + K++RK +Q + Q
Sbjct: 168 NCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHAD---------Q 218
Query: 190 GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKV 249
+ + G + S E +LT Q+ ++ ++ + NK+ + +
Sbjct: 219 TVNEDSEGRDL----RQVTSTTKSCREKTELTPDQQTLLHFIMDSY---NKQRMPQE--I 269
Query: 250 TPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTI 309
T L + + ++ F TE+A VQ +V+F K++PGF L EDQIALLK S +
Sbjct: 270 TNKIL----KEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAV 325
Query: 310 EIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAE 369
E M L +A +N + ++ +G+ E+I P+F F +++ L + E
Sbjct: 326 EAMFLRSAEIFNKKLPS----GHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
Query: 370 YALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLR 429
YALL AI I S DR +++ VE LQ+P ++ L +I +P++ F +L +L LR
Sbjct: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
Query: 430 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 459
T + H+E + + R+ D K PLL EIWDV
Sbjct: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
>gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
Length = 387
Score = 231 bits (589), Expect = 1e-60
Identities = 117/153 (76%), Positives = 133/153 (86%)
Query: 309 IEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368
+ +MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L L+DA
Sbjct: 235 VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDA 294
Query: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSL 428
E+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLMKLVSL
Sbjct: 295 EFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSL 354
Query: 429 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 355 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 387
Score = 211 bits (537), Expect = 1e-54
Identities = 120/250 (48%), Positives = 153/250 (61%), Gaps = 29/250 (11%)
Query: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62
P S+++ PG A S + +EE P G V G + A
Sbjct: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71
Query: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G
Sbjct: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130
Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ +
Sbjct: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189
Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
S P ++S P P QL+ Q MI++LVAAQ QCN+
Sbjct: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226
Query: 241 RSFSDQPKVT 250
RSFSD+ +VT
Sbjct: 227 RSFSDRLRVT 236
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 206 bits (523), Expect = 5e-53
Identities = 138/454 (30%), Positives = 222/454 (48%), Gaps = 65/454 (14%)
Query: 14 PGNGPPQPGAPSSSPTVKEEGPE------PWPGGPDPDVPGTDEASSACSTDWVIPDPEE 67
PG+G P G P + P P + G PD+P + ++ S + EE
Sbjct: 16 PGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLP---KEMASLSVETQSTSSEE 72
Query: 68 EPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRG 127
P P++ ++ C VC DK+SG+HY V SCEGCKGFFRRS+ + Y C
Sbjct: 73 MVPSSPSPPPPPRV--YKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMV--YTCHR 128
Query: 128 GGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVG 187
C ++ R +CQ CRL+KC E GM ++ V ++ +KK+++++ +S S
Sbjct: 129 DKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS----- 183
Query: 188 PQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQP 247
PQ +++L+ + ++ +F
Sbjct: 184 PQ--------------------------------------LEELITKVSKAHQETFPSLC 205
Query: 248 KVTPWPLGADPQSRDARQQR----FAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIAL 303
++ + + S D R Q + F+ELA + +IV+FAK++PGF L DQI L
Sbjct: 206 QLGKYTTNS---SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITL 262
Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363
LKA+ ++I++L RY E + +TF T ++ H AG + +F F+ + L
Sbjct: 263 LKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPL 321
Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423
+DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +RP FPRMLM
Sbjct: 322 EMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLM 381
Query: 424 KLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456
K+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 382 KITDLRGISTKGAERAITLKMEIPGPMPPLIREM 415
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 204 bits (519), Expect = 1e-52
Identities = 145/474 (30%), Positives = 226/474 (47%), Gaps = 76/474 (16%)
Query: 6 TSSLDTPLPGNG--------------PPQPGA---PSSSPTVKEEGPEPWPGGPDPDVPG 48
++S P PG G PP G P + T++ + P P P
Sbjct: 3 SNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIE 62
Query: 49 TDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCK 108
T +SS + ++P P P P P++ ++ C VC DK+SG+HY V +CEGCK
Sbjct: 63 TQSSSS----EEIVPSPPSPP-------PLPRI--YKPCFVCQDKSSGYHYGVSACEGCK 109
Query: 109 GFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKK 168
GFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V ++ +KK
Sbjct: 110 GFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK 167
Query: 169 KIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
++ K P+ S S P E G +L
Sbjct: 168 EVPK---------------PECSESYTLTP-------EVG----------ELIEKVRKAH 195
Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
Q+ A Q K + ++ + Q + F+EL+ + + V+FAKQ
Sbjct: 196 QETFPALCQLGKYTTNNSSE----------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 245
Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVE 348
+PGF L DQI LLKA+ ++I++L RY E + +TF T ++ H AG
Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 304
Query: 349 FINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR 408
+ +F F+ + L +DDAE LL AI + DR ++++P RV+ LQ+P +EAL Y R
Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364
Query: 409 IKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
+RP FP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 365 KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 204 bits (519), Expect = 1e-52
Identities = 145/474 (30%), Positives = 226/474 (47%), Gaps = 76/474 (16%)
Query: 6 TSSLDTPLPGNG--------------PPQPGA---PSSSPTVKEEGPEPWPGGPDPDVPG 48
++S P PG G PP G P + T++ + P P P
Sbjct: 3 SNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIE 62
Query: 49 TDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCK 108
T +SS + ++P P P P P++ ++ C VC DK+SG+HY V +CEGCK
Sbjct: 63 TQSSSS----EEIVPSPPSPP-------PLPRI--YKPCFVCQDKSSGYHYGVSACEGCK 109
Query: 109 GFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKK 168
GFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V ++ +KK
Sbjct: 110 GFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK 167
Query: 169 KIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
++ K P+ S S P E G +L
Sbjct: 168 EVPK---------------PECSESYTLTP-------EVG----------ELIEKVRKAH 195
Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
Q+ A Q K + ++ + Q + F+EL+ + + V+FAKQ
Sbjct: 196 QETFPALCQLGKYTTNNSSE----------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 245
Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVE 348
+PGF L DQI LLKA+ ++I++L RY E + +TF T ++ H AG
Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 304
Query: 349 FINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR 408
+ +F F+ + L +DDAE LL AI + DR ++++P RV+ LQ+P +EAL Y R
Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364
Query: 409 IKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
+RP FP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 365 KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 202 bits (513), Expect = 7e-52
Identities = 141/450 (31%), Positives = 221/450 (49%), Gaps = 66/450 (14%)
Query: 13 LPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERK 72
LP G P PG P S+P P G + + + + S++ ++P P P
Sbjct: 29 LPEKGLPAPG-PYSTPL-----RTPLWNGSNHSIE-----TQSSSSEEIVPSPPSPP--- 74
Query: 73 RKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQ 132
P P++ ++ C VC DK+SG+HY V +CEGCKGFFRRS+ + Y C C
Sbjct: 75 ----PLPRI--YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMV--YTCHRDKNCI 126
Query: 133 MDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSS 192
++ R +CQ CRL+KC E GM ++ V ++ +KK++ K P+ S
Sbjct: 127 INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPK---------------PECSE 171
Query: 193 SSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPW 252
S P E G +L Q+ A Q K + ++ +
Sbjct: 172 SYTLTP-------EVG----------ELIEKVRKAHQETFPALCQLGKYTTNNSSE---- 210
Query: 253 PLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIM 312
Q + F+EL+ + + V+FAKQ+PGF L DQI LLKA+ ++I+
Sbjct: 211 ------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
Query: 313 LLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL 372
+L RY E + +TF T ++ H AG + +F F+ + L +DDAE L
Sbjct: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGL 323
Query: 373 LIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLS 432
L AI + DR ++++P RV+ LQ+P +EAL Y R +RP FP+MLMK+ LR++S
Sbjct: 324 LSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSIS 383
Query: 433 SVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
+ +E+V L+++ +PPL+ E+ + E
Sbjct: 384 AKGAERVITLKMEIPGSMPPLIQEMLENSE 413
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 199 bits (505), Expect = 6e-51
Identities = 130/420 (30%), Positives = 206/420 (49%), Gaps = 64/420 (15%)
Query: 42 PDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNV 101
P P + E S S + V P P P ++ C VC DK+SG+HY V
Sbjct: 44 PQPASLQSVETQSTSSEEMVPSSPS----------PPPPPRVYKPCFVCNDKSSGYHYGV 93
Query: 102 LSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLS 161
SCEGCKGFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V +
Sbjct: 94 SSCEGCKGFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRN 151
Query: 162 EEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLT 221
+ +KK+++++ +S S PQ
Sbjct: 152 DRNKKKKEVKEEGSPDSYELS-----PQ-------------------------------- 174
Query: 222 AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR----FAHFTELAII 277
+++L+ + ++ +F ++ + + S D R Q + F+ELA
Sbjct: 175 ------LEELITKVSKAHQETFPSLCQLGKYTTNS---SADHRVQLDLGLWDKFSELATK 225
Query: 278 SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSK 337
+ +IV+FAK++PGF L DQI LLKA+ ++I++L RY E + +TF T ++
Sbjct: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
Query: 338 DDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ 397
H AG + +F F+ + L +DD E LL AI + DR +++EP +V+ LQ+
Sbjct: 286 TQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQE 344
Query: 398 PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456
P +EAL Y R +RP FPRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 345 PLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 197 bits (502), Expect = 1e-50
Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%)
Query: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ R + C G C++ RR CQ CR
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80
Query: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189
L++C + GM ++ +L++E++++K+ I K++++E+ S P +
Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140
Query: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
G S S P + S +G S + +T++ M+
Sbjct: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197
Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
+ L ++ SD P VT ++ H +L S+Q+++ FAK
Sbjct: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247
Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347
+PGF L EDQI LLK+S IE+++L + + + T +D+ Y D +AG +
Sbjct: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307
Query: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407
E I P+ +F +++L L + E+ LL+AI I S DRP VQ+ +EA+Q L +Y
Sbjct: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367
Query: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457
R + P L + +M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 197 bits (502), Expect = 1e-50
Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%)
Query: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ R + C G C++ RR CQ CR
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80
Query: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189
L++C + GM ++ +L++E++++K+ I K++++E+ S P +
Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140
Query: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228
G S S P + S +G S + +T++ M+
Sbjct: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197
Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288
+ L ++ SD P VT ++ H +L S+Q+++ FAK
Sbjct: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247
Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347
+PGF L EDQI LLK+S IE+++L + + + T +D+ Y D +AG +
Sbjct: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307
Query: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407
E I P+ +F +++L L + E+ LL+AI I S DRP VQ+ +EA+Q L +Y
Sbjct: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367
Query: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457
R + P L + +M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 194 bits (492), Expect = 2e-49
Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%)
Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126
+ E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+
Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146
Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184
G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q
Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206
Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244
+G + + + E + E + KR F
Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246
Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304
+ + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL
Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305
Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364
K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++
Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364
Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424
LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK
Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424
Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458
+ LR + + H+ + ++++ + PPL E+++
Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 194 bits (492), Expect = 2e-49
Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%)
Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126
+ E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+
Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146
Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184
G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q
Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206
Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244
+G + + + E + E + KR F
Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246
Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304
+ + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL
Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305
Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364
K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++
Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364
Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424
LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK
Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424
Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458
+ LR + + H+ + ++++ + PPL E+++
Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 194 bits (492), Expect = 2e-49
Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%)
Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126
+ E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+
Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146
Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184
G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q
Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206
Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244
+G + + + E + E + KR F
Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246
Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304
+ + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL
Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305
Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364
K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++
Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364
Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424
LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK
Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424
Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458
+ LR + + H+ + ++++ + PPL E+++
Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 191 bits (485), Expect = 1e-48
Identities = 123/411 (29%), Positives = 208/411 (50%), Gaps = 57/411 (13%)
Query: 53 SSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFR 112
+ + S++ ++P P P P ++ C VC DK+SG+HY V +CEGCKGFFR
Sbjct: 56 TQSTSSEELVPSPPS---------PLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFR 106
Query: 113 RSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRK 172
RS+ + Y C C ++ R +CQ CRL+KC E GM S+E +R + +K
Sbjct: 107 RSIQKNMI--YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGM------SKESVRNDRNKK 158
Query: 173 QQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLV 232
+++ Q ++S ++TA + + +++
Sbjct: 159 KKETSKQECTES---------------------------------YEMTAELDDLTEKIR 185
Query: 233 AAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR-FAHFTELAIISVQEIVDFAKQVPG 291
A ++ +F ++ + + R + F+ELA + +IV+FAK++PG
Sbjct: 186 KA----HQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPG 241
Query: 292 FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFIN 351
F L DQI LLKA+ ++I++L RY E + +TF T ++ H AG +
Sbjct: 242 FTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTD 300
Query: 352 PIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKR 411
+F F+ + L +DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +R
Sbjct: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
Query: 412 PQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461
P FP++LMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 185 bits (469), Expect = 9e-47
Identities = 125/396 (31%), Positives = 211/396 (53%), Gaps = 57/396 (14%)
Query: 83 GHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQ 142
G ++CRVCGDKA+G+H+NV++CEGCKGFFRR++ R R R G C++ RR+CQ
Sbjct: 37 GPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGA-CEITRKTRRQCQ 95
Query: 143 QCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASP 202
CRLRKC E+GM+++ ++S+E + +++ ++++ ++ +Q P+G QG
Sbjct: 96 ACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQ-PLGVQG------------ 142
Query: 203 GGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQP--KVTPWPLGAD--- 257
LT Q +MI++L+ AQ++ +FS +V+ G D
Sbjct: 143 -----------------LTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185
Query: 258 ----PQSRDARQQRFA---HFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIE 310
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK + E
Sbjct: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245
Query: 311 IMLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD 367
+ L +N ET EC +Y +D G Q + P+ +F +++L L +
Sbjct: 246 LCQLRFNTVFNAETGTWEC----GRLSYCLEDT-AGGFQQLLLEPMLKFHYMLKKLQLHE 300
Query: 368 AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKL 425
EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L
Sbjct: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360
Query: 426 VSLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459
LR++++ H++++ LR+QD PL+ E++ +
Sbjct: 361 TELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 394
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 180 bits (456), Expect = 3e-45
Identities = 119/418 (28%), Positives = 201/418 (48%), Gaps = 41/418 (9%)
Query: 64 DPEE------EPERKRKKGPAP---KMLGH--------ELCRVCGDKASGFHYNVLSCEG 106
DPEE + +RKRK G M G+ E C VCGDKA+G+HY ++CEG
Sbjct: 13 DPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEG 72
Query: 107 CKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSE-EQI 165
CKGFFRR++ + Y+C+ C +D R +CQ CR +KC GM VL + +++
Sbjct: 73 CKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRV 132
Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225
K+K+ +Q ++ + + Q + +EA + +G +
Sbjct: 133 AKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWK------ 186
Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285
+R F + P+ + P + F+ FT++ ++ +VDF
Sbjct: 187 -------------QRRKFLPDD-IGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345
AK++P F +L EDQI LLK +EIM L A RY+ E++ +T + ++ GL
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405
V + IFE +++ LDD E ALL A+ + S DR + ++E Q+ Y+ A
Sbjct: 293 GV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351
Query: 406 YTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWDVHE 461
Y ++ +P++LMK+ LR + + H+ + ++++ + PPL E+++ E
Sbjct: 352 YVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQE 409
>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
2 [Homo sapiens]
Length = 473
Score = 175 bits (444), Expect = 7e-44
Identities = 130/455 (28%), Positives = 223/455 (49%), Gaps = 51/455 (11%)
Query: 39 PGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFH 98
P GP+ ++ + S D+V + E K ++ G ++CRVCGDKA+G+H
Sbjct: 33 PRGPEANLEVRPKESWN-HADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYH 91
Query: 99 YNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQC 158
+NV++CEGCKGFFRR++ R R R G C++ RR+CQ CRLRKC E+GM+++
Sbjct: 92 FNVMTCEGCKGFFRRAMKRNARLRCPFR-KGACEITRKTRRQCQACRLRKCLESGMKKEM 150
Query: 159 VLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG--------------------- 197
++S+E + +++ ++++ ++ +Q P+G QG +
Sbjct: 151 IMSDEAVEERRALIKRKKSERTGTQ-PLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFK 209
Query: 198 ----PGASPGGSE--AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTP 251
PG G E Q E + + ++ + V+ QL+ + V
Sbjct: 210 NFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLR------GEDGSVWN 263
Query: 252 WPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEI 311
+ AD ++ H +++ + I+ FAK + F L EDQI+LLK + E+
Sbjct: 264 YKPPADSGGKEI-FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFEL 322
Query: 312 MLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368
L +N ET EC +Y +D G Q + P+ +F +++L L +
Sbjct: 323 CQLRFNTVFNAETGTWEC----GRLSYCLED-TAGGFQQLLLEPMLKFHYMLKKLQLHEE 377
Query: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKLV 426
EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L
Sbjct: 378 EYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLT 437
Query: 427 SLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459
LR++++ H++++ LR+QD PL+ E++ +
Sbjct: 438 ELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 470
>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
1 [Homo sapiens]
Length = 434
Score = 175 bits (443), Expect = 9e-44
Identities = 122/411 (29%), Positives = 207/411 (50%), Gaps = 50/411 (12%)
Query: 83 GHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQ 142
G ++CRVCGDKA+G+H+NV++CEGCKGFFRR++ R R R G C++ RR+CQ
Sbjct: 37 GPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR-KGACEITRKTRRQCQ 95
Query: 143 QCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG----- 197
CRLRKC E+GM+++ ++S+E + +++ ++++ ++ +Q P+G QG +
Sbjct: 96 ACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQ-PLGVQGLTEEQRMMIREL 154
Query: 198 --------------------PGASPGGSE--AGSQGSGEGEGVQLTAAQELMIQQLVAAQ 235
PG G E Q E + + ++ + V+ Q
Sbjct: 155 MDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQ 214
Query: 236 LQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQL 295
L+ + V + AD ++ H +++ + I+ FAK + F L
Sbjct: 215 LR------GEDGSVWNYKPPADSGGKEI-FSLLPHMADMSTYMFKGIISFAKVISYFRDL 267
Query: 296 GREDQIALLKASTIEIMLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINP 352
EDQI+LLK + E+ L +N ET EC +Y +D G Q + P
Sbjct: 268 PIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC----GRLSYCLED-TAGGFQQLLLEP 322
Query: 353 IFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRP 412
+ +F +++L L + EY L+ AI++FS DRP V + V+ LQ+ + L SY RP
Sbjct: 323 MLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRP 382
Query: 413 QDQLR--FPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459
Q R F +++ L LR++++ H++++ LR+QD PL+ E++ +
Sbjct: 383 QPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 431
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 170 bits (430), Expect = 3e-42
Identities = 115/383 (30%), Positives = 184/383 (48%), Gaps = 60/383 (15%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68
Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206
+KC +AGMR+ +LS E + ++ ++ Q++ Q+
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103
Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266
VQL+ QE +I+ L+ A + F + P P Q
Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146
Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316
HF ++ V +++ F K +P F L EDQI+LLK + +EI +
Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206
Query: 317 ARRYNHETECITFL-KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIA 375
+ +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY LL A
Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAA 264
Query: 376 INIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMKLVSLRTLSS 433
+ +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L L LR+++
Sbjct: 265 MALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINE 324
Query: 434 VHSEQVFALRLQDKKLPPLLSEI 456
+ Q+ ++ + PLL EI
Sbjct: 325 AYGYQIQHIQGLSAMM-PLLQEI 346
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 165 bits (417), Expect = 9e-41
Identities = 111/379 (29%), Positives = 180/379 (47%), Gaps = 39/379 (10%)
Query: 64 DPEE------EPERKRKKGPAP---KMLGH--------ELCRVCGDKASGFHYNVLSCEG 106
DPEE + +RKRK G M G+ E C VCGDKA+G+HY ++CEG
Sbjct: 13 DPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEG 72
Query: 107 CKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSE-EQI 165
CKGFFRR++ + Y+C+ C +D R +CQ CR +KC GM VL + +++
Sbjct: 73 CKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRV 132
Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225
K+K+ +Q ++ + + Q + +EA + +G +
Sbjct: 133 AKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWK------ 186
Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285
+R F + P+ + P + F+ FT++ ++ +VDF
Sbjct: 187 -------------QRRKFLPD-DIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345
AK++P F +L EDQI LLK +EIM L A RY+ E++ +T + ++ GL
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405
V + IFE +++ LDD E ALL A+ + S DR + ++E Q+ Y+ A
Sbjct: 293 GV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351
Query: 406 YTRIKRPQDQLRFPRMLMK 424
Y ++ +P++LMK
Sbjct: 352 YVNHRKHNIPHFWPKLLMK 370
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 164 bits (415), Expect = 2e-40
Identities = 115/387 (29%), Positives = 184/387 (47%), Gaps = 64/387 (16%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68
Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206
+KC +AGMR+ +LS E + ++ ++ Q++ Q+
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103
Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266
VQL+ QE +I+ L+ A + F + P P Q
Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146
Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316
HF ++ V +++ F K +P F L EDQI+LLK + +EI +
Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206
Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371
+ +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY
Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264
Query: 372 LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMKLVSLR 429
LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L L LR
Sbjct: 265 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELR 324
Query: 430 TLSSVHSEQVFALRLQDKKLPPLLSEI 456
+++ + Q+ ++ + PLL EI
Sbjct: 325 SINEAYGYQIQHIQGLSAMM-PLLQEI 350
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 160 bits (406), Expect = 2e-39
Identities = 123/459 (26%), Positives = 193/459 (42%), Gaps = 68/459 (14%)
Query: 4 PTTSSLDTPLPGNG----PPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTD 59
P S L G+G PP P P SP PG P P PG S+ +
Sbjct: 104 PLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQIN 163
Query: 60 WVI--------PDPEEEPERKRKKG------PAPKMLGHELCRVCGDKASGFHYNVLSCE 105
+ P + +P +G P G LC +CGD++SG HY V SCE
Sbjct: 164 STVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCE 223
Query: 106 GCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQI 165
GCKGFF+R++ + Y+CR C +D R +CQ CR +KC GM+ + V E Q
Sbjct: 224 GCKGFFKRTIRKD--LTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQR 281
Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225
K K G GEG G A +E
Sbjct: 282 GKDK----------------------------------------DGDGEGAG---GAPEE 298
Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285
+ + +++ A+L ++S DQ P G S + + + + +V++
Sbjct: 299 MPVDRILEAELAVEQKS--DQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFT---LVEW 353
Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345
AK++P F L +DQ+ LL+A E+++ + R + I ++ H AG+
Sbjct: 354 AKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGV 413
Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405
F + E MR + +D E L AI +F+ D + P VE L++ +L +
Sbjct: 414 GAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLET 473
Query: 406 YTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRL 444
Y + K P+ Q RF ++L++L +LR++ E +F +L
Sbjct: 474 YCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKL 512
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 158 bits (400), Expect = 9e-39
Identities = 115/392 (29%), Positives = 184/392 (46%), Gaps = 69/392 (17%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68
Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206
+KC +AGMR+ +LS E + ++ ++ Q++ Q+
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103
Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266
VQL+ QE +I+ L+ A + F + P P Q
Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146
Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316
HF ++ V +++ F K +P F L EDQI+LLK + +EI +
Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206
Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371
+ +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY
Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264
Query: 372 LLIAINIFS-----ADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMK 424
LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L
Sbjct: 265 LLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGL 324
Query: 425 LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 456
L LR+++ + Q+ ++ + PLL EI
Sbjct: 325 LAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 355
>gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens]
Length = 523
Score = 154 bits (390), Expect = 1e-37
Identities = 129/519 (24%), Positives = 228/519 (43%), Gaps = 106/519 (20%)
Query: 36 EPWPGGPDPDV--PGTDEASSACSTDWVIPDPEEEPERKRKKGPAP-------------- 79
E P PDP PG+ A +A + P + ++ + PAP
Sbjct: 2 ESAPAAPDPAASEPGSSGADAAAGSR---ETPLNQESARKSEPPAPVRRQSYSSTSRGIS 58
Query: 80 -------KMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQ 132
+ C++CGDK+SG HY V++CEGCKGFFRRS Y+C C
Sbjct: 59 VTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCL 116
Query: 133 MDAFMRRKCQQCRLRKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQ 181
+D R +CQ CRL+KC GM V +S++Q ++K ++++QQ+ Q
Sbjct: 117 IDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQP 176
Query: 182 SQSPVGPQGSSSSASG------------PGASPGGSEAGS---------QGSGEGEGVQL 220
++ + SA+G G +P GS+A S Q S + G+ +
Sbjct: 177 GEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDI 236
Query: 221 T---------------------------------AAQELMIQQLVAAQLQCNKRSFSDQP 247
A E + Q + + L+ + +
Sbjct: 237 NGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQ 296
Query: 248 KVTPWPLGADPQSRDARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIAL 303
++T W + + + ++ +L I + E +V+FAK++ GF++L + DQI L
Sbjct: 297 QIT-WQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 355
Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363
LKA ++E++ + R ++ + + F D Y+ D ++ +FI+ +FEF +++ +
Sbjct: 356 LKAGSLEVVFIRMCRAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSM 413
Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423
L + E AL A + SADR +QE ++E LQQ ++ L + K ++ +++
Sbjct: 414 HLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLIC 472
Query: 424 KLVSLRTLSSVHSEQVFALR-----LQDKKLPPLLSEIW 457
K+ +LR L H+E++ A + + PPL E++
Sbjct: 473 KVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELF 511
>gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens]
Length = 468
Score = 154 bits (389), Expect = 2e-37
Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL
Sbjct: 18 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 75
Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195
+KC GM V +S++Q ++K ++++QQ+ Q ++ + SA
Sbjct: 76 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 135
Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221
+G G +P GS+A S Q S + G+ +
Sbjct: 136 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 195
Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261
A E + Q + + L+ + + ++T W +
Sbjct: 196 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 254
Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317
+ + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ +
Sbjct: 255 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 314
Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377
R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A
Sbjct: 315 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 372
Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437
+ SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E
Sbjct: 373 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 431
Query: 438 QVFALR-----LQDKKLPPLLSEIW 457
++ A + + PPL E++
Sbjct: 432 KLMAFKAIYPDIVRLHFPPLYKELF 456
>gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens]
Length = 548
Score = 154 bits (389), Expect = 2e-37
Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL
Sbjct: 98 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 155
Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195
+KC GM V +S++Q ++K ++++QQ+ Q ++ + SA
Sbjct: 156 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 215
Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221
+G G +P GS+A S Q S + G+ +
Sbjct: 216 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 275
Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261
A E + Q + + L+ + + ++T W +
Sbjct: 276 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 334
Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317
+ + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ +
Sbjct: 335 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 394
Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377
R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A
Sbjct: 395 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 452
Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437
+ SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E
Sbjct: 453 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 511
Query: 438 QVFALR-----LQDKKLPPLLSEIW 457
++ A + + PPL E++
Sbjct: 512 KLMAFKAIYPDIVRLHFPPLYKELF 536
>gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens]
Length = 556
Score = 154 bits (389), Expect = 2e-37
Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL
Sbjct: 106 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 163
Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195
+KC GM V +S++Q ++K ++++QQ+ Q ++ + SA
Sbjct: 164 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 223
Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221
+G G +P GS+A S Q S + G+ +
Sbjct: 224 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 283
Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261
A E + Q + + L+ + + ++T W +
Sbjct: 284 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 342
Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317
+ + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ +
Sbjct: 343 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 402
Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377
R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A
Sbjct: 403 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 460
Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437
+ SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E
Sbjct: 461 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 519
Query: 438 QVFALR-----LQDKKLPPLLSEIW 457
++ A + + PPL E++
Sbjct: 520 KLMAFKAIYPDIVRLHFPPLYKELF 544
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 152 bits (383), Expect = 8e-37
Identities = 105/346 (30%), Positives = 163/346 (47%), Gaps = 63/346 (18%)
Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146
C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68
Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206
+KC +AGMR+ +LS E + ++ ++ Q++ Q+
Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103
Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266
VQL+ QE +I+ L+ A + F + P P Q
Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146
Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316
HF ++ V +++ F K +P F L EDQI+LLK + +EI +
Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206
Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371
+ +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY
Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264
Query: 372 LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQ 415
LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+
Sbjct: 265 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,109,453
Number of Sequences: 37866
Number of extensions: 1260724
Number of successful extensions: 17460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 378
Number of HSP's that attempted gapping in prelim test: 13925
Number of HSP's gapped (non-prelim): 3176
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.