Search of human proteins with 8394417

Search of human proteins with 8394417

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8394417 par-6 partitioning defective 6 homolog alpha isoform
1 [Homo sapiens]
         (346 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8394417 par-6 partitioning defective 6 homolog alpha isoform ...   689   0.0  
gi|82659097 par-6 partitioning defective 6 homolog alpha isoform...   683   0.0  
gi|62955042 PAR-6 beta [Homo sapiens]                                 328   4e-90
gi|14210518 PAR-6 gamma protein [Homo sapiens]                        327   1e-89
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]           62   1e-09
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]            56   5e-08
gi|186972120 calcium/calmodulin-dependent serine protein kinase ...    50   4e-06
gi|45827729 scribble isoform b [Homo sapiens]                          50   4e-06
gi|45827731 scribble isoform a [Homo sapiens]                          50   4e-06
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]           48   1e-05
gi|41281808 harmonin isoform b3 [Homo sapiens]                         48   1e-05
gi|71480164 harmonin isoform a [Homo sapiens]                          48   1e-05
gi|148746189 multiple PDZ domain protein [Homo sapiens]                47   2e-05
gi|186700629 calcium/calmodulin-dependent serine protein kinase ...    47   3e-05
gi|186700627 calcium/calmodulin-dependent serine protein kinase ...    47   3e-05
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]           47   3e-05
gi|24025688 ligand of numb-protein X 2 [Homo sapiens]                  46   4e-05
gi|13376349 PDZ domain containing 7 [Homo sapiens]                     45   1e-04
gi|112382257 InaD-like [Homo sapiens]                                  44   2e-04
gi|150170670 piccolo isoform 2 [Homo sapiens]                          44   2e-04
gi|150378539 piccolo isoform 1 [Homo sapiens]                          44   2e-04
gi|4759306 lin-7 homolog A [Homo sapiens]                              44   2e-04
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora...    43   4e-04
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora...    43   4e-04
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora...    43   4e-04
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                          43   4e-04
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]           43   5e-04
gi|21361142 PDZ domain containing 1 [Homo sapiens]                     43   5e-04
gi|11545920 lin-7 homolog B [Homo sapiens]                             43   5e-04
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    42   6e-04

>gi|8394417 par-6 partitioning defective 6 homolog alpha isoform 1
           [Homo sapiens]
          Length = 346

 Score =  689 bits (1779), Expect = 0.0
 Identities = 346/346 (100%), Positives = 346/346 (100%)

Query: 1   MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG 60
           MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG
Sbjct: 1   MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG 60

Query: 61  YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLR 120
           YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLR
Sbjct: 61  YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLR 120

Query: 121 PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR 180
           PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR
Sbjct: 121 PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR 180

Query: 181 VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH 240
           VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH
Sbjct: 181 VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH 240

Query: 241 NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ 300
           NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ
Sbjct: 241 NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ 300

Query: 301 GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL 346
           GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
Sbjct: 301 GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL 346


>gi|82659097 par-6 partitioning defective 6 homolog alpha isoform 2
           [Homo sapiens]
          Length = 345

 Score =  683 bits (1763), Expect = 0.0
 Identities = 345/346 (99%), Positives = 345/346 (99%), Gaps = 1/346 (0%)

Query: 1   MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG 60
           MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG
Sbjct: 1   MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLG 60

Query: 61  YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLR 120
           YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKR EADSSGLAFASNSLQRRKKGLLLR
Sbjct: 61  YTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKR-EADSSGLAFASNSLQRRKKGLLLR 119

Query: 121 PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR 180
           PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR
Sbjct: 120 PVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVR 179

Query: 181 VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH 240
           VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH
Sbjct: 180 VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSH 239

Query: 241 NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ 300
           NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ
Sbjct: 240 NLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQ 299

Query: 301 GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL 346
           GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
Sbjct: 300 GPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL 345


>gi|62955042 PAR-6 beta [Homo sapiens]
          Length = 372

 Score =  328 bits (841), Expect = 4e-90
 Identities = 175/291 (60%), Positives = 224/291 (76%), Gaps = 16/291 (5%)

Query: 16  VEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDD 75
           +EVKSKF AEFRRF+L R+    F+EF  LL+ VH+IP +DVL+GY D HGDLLP+ NDD
Sbjct: 17  MEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDD 76

Query: 76  SLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGL--LLRPVAPLRTRPPLLI 133
           + H+A+++  P LR+ +QK+ EAD S  AF +++L ++K  L  +LRP    R +P ++I
Sbjct: 77  NYHKAVSTANPLLRIFIQKKEEADYS--AFGTDTLIKKKNVLTNVLRPDNH-RKKPHIVI 133

Query: 134 SLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIF 193
           S+PQDFR VSS+IDVD+LPETHRRVRL+K+G+++PLGFYIRDG SVRV P GLE+VPGIF
Sbjct: 134 SMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIF 193

Query: 194 ISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRN 253
           ISRLV GGLA+STGLLAV+DE+LEVNGIEV+GK+LDQVTDMM+ANS NLI+TV+PANQRN
Sbjct: 194 ISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRN 253

Query: 254 NVVR-----GASGRLTGPPSAG-PGPAEP-----DSDDDSSDLVIENRQPP 293
           NVVR     G+SG+ T     G P   EP     D D +  D++IE+   P
Sbjct: 254 NVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVP 304


>gi|14210518 PAR-6 gamma protein [Homo sapiens]
          Length = 376

 Score =  327 bits (837), Expect = 1e-89
 Identities = 183/311 (58%), Positives = 218/311 (70%), Gaps = 21/311 (6%)

Query: 14  SIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTN 73
           S VEVKSKF AEFRRF+L R     F++F +L+   H I   DV +GY D HGDLLP+ N
Sbjct: 17  SAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINN 76

Query: 74  DDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGL-LLRPVAPLRTRPPLL 132
           DD+  +A++S  P LR+ +QKR EA+   L   + SL RR++ L  LR   P R R  L 
Sbjct: 77  DDNFCKAVSSANPLLRVFIQKREEAERGSLG--AGSLCRRRRALGALRDEGP-RRRAHLD 133

Query: 133 ISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGI 192
           I LP+DFR VSS+IDVDL+PETHRRVRLH+HG ++PLGFYIRDG SVRV P GLE+VPGI
Sbjct: 134 IGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGI 193

Query: 193 FISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQR 252
           FISR+V GGLAESTGLLAV+DE+LEVNGIEVAGKTLDQVTDMM+ANSHNLIVTVKPANQR
Sbjct: 194 FISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQR 253

Query: 253 NNVVRGASG-RLTGPPSAGPG---------------PAEPDSDDDSSDLVIENRQPPSSN 296
           NNVVRG      +GPPS G                 P E +SD+D +D+VIE    P+  
Sbjct: 254 NNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDED-NDVVIEGTLEPARP 312

Query: 297 GLSQGPPCWDL 307
             + G P   L
Sbjct: 313 PQTPGAPAGSL 323


>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
          Length = 675

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 37/99 (37%), Positives = 55/99 (55%), Gaps = 13/99 (13%)

Query: 153 ETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVS 212
           ET + VR+ K   D PLG  +R+ M              + ISR+V+GG AE +GLL   
Sbjct: 252 ETVKIVRIEK-ARDIPLGATVRNEMD------------SVIISRIVKGGAAEKSGLLHEG 298

Query: 213 DEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQ 251
           DE+LE+NGIE+ GK +++V D++      L   + P+ Q
Sbjct: 299 DEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQ 337


>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
          Length = 585

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 40/138 (28%), Positives = 68/138 (49%), Gaps = 19/138 (13%)

Query: 117 LLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDG 176
           L++      +   P+L  LP +       ID D   E+ + VRL K+    PLG  IR  
Sbjct: 104 LMVHDTVAQKNFDPVLPPLPDN-------IDEDFDEESVKIVRLVKN--KEPLGATIRRD 154

Query: 177 MSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMV 236
                     E    + ++R++RGG A+ +GL+ V DE+ EVNGI V  K  D+++ ++ 
Sbjct: 155 ----------EHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILA 204

Query: 237 ANSHNLIVTVKPANQRNN 254
            +  ++ + + PA Q  +
Sbjct: 205 QSQGSITLKIIPATQEED 222


>gi|186972120 calcium/calmodulin-dependent serine protein kinase
           isoform 1 [Homo sapiens]
          Length = 921

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 46/195 (23%), Positives = 78/195 (40%), Gaps = 14/195 (7%)

Query: 125 LRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQ 184
           LR  PP            S+  D+D+   T  R+   +  +D P+G  ++          
Sbjct: 457 LRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK---------- 506

Query: 185 GLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIV 244
            +  +    ++R++ GG+    G L V DEI E+NGI VA +T++Q+  M+     ++  
Sbjct: 507 -MNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 565

Query: 245 TVKPA--NQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGP 302
            + P+   Q ++  R +       P+ G         D  S    + RQ          P
Sbjct: 566 KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP 625

Query: 303 PCWDLHPGCRHPGTR 317
              DL P C+  G R
Sbjct: 626 AKDDLIP-CKEAGIR 639


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 36/112 (32%), Positives = 50/112 (44%), Gaps = 14/112 (12%)

Query: 165 SDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVA 224
           S+R LGF I  G        G     GIF+SR+  GG A   G L V D +L +NG++V 
Sbjct: 868 SERGLGFSIAGGKGSTPYRAG---DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924

Query: 225 GKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEP 276
               D    ++ A S  + + ++         R A G L  PPS  P  + P
Sbjct: 925 EARHDHAVSLLTAASPTIALLLE---------REAGGPL--PPSPLPHSSPP 965



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 40/137 (29%), Positives = 59/137 (43%), Gaps = 8/137 (5%)

Query: 152  PETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAV 211
            P     +RL + G   PLG  I  G      P G++  PG+FIS+++  GLA  +G L V
Sbjct: 999  PYPVEEIRLPRAGG--PLGLSIVGGSDHSSHPFGVQE-PGVFISKVLPRGLAARSG-LRV 1054

Query: 212  SDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK----PANQRNNVVRGASGRLTGPP 267
             D IL VNG +V   T  +    ++     L + V+    P   R   ++ A G   G  
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGIS 1114

Query: 268  SAGPGPAEPDSDDDSSD 284
              G       +  D +D
Sbjct: 1115 IRGGARGHAGNPRDPTD 1131



 Score = 34.3 bits (77), Expect = 0.17
 Identities = 43/172 (25%), Positives = 66/172 (38%), Gaps = 7/172 (4%)

Query: 141  QVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRG 200
            ++S ++  D  P   R + + K   +R LG  IR G              GIFIS++   
Sbjct: 1084 ELSLLVRRDPAPPGLRELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPT 1142

Query: 201  GLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNN--VVRG 258
            G A   G L V   +LEVN   + G T  +   ++ +    L V V    + +    +  
Sbjct: 1143 GAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEV 1202

Query: 259  ASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPG 310
            + G +  P +AG G         S    I+    P   G  +  P   LH G
Sbjct: 1203 SPGVIANPFAAGIGHRNSLESISS----IDRELSPEGPGKEKELPGQTLHWG 1250



 Score = 32.0 bits (71), Expect = 0.84
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)

Query: 191 GIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAG 225
           GIFISR+   G A   G+  V D++LEVNG+ + G
Sbjct: 757 GIFISRVSEEGPAARAGV-RVGDKLLEVNGVALQG 790


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 36/112 (32%), Positives = 50/112 (44%), Gaps = 14/112 (12%)

Query: 165 SDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVA 224
           S+R LGF I  G        G     GIF+SR+  GG A   G L V D +L +NG++V 
Sbjct: 868 SERGLGFSIAGGKGSTPYRAG---DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924

Query: 225 GKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEP 276
               D    ++ A S  + + ++         R A G L  PPS  P  + P
Sbjct: 925 EARHDHAVSLLTAASPTIALLLE---------REAGGPL--PPSPLPHSSPP 965



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 40/137 (29%), Positives = 59/137 (43%), Gaps = 8/137 (5%)

Query: 152  PETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAV 211
            P     +RL + G   PLG  I  G      P G++  PG+FIS+++  GLA  +G L V
Sbjct: 999  PYPVEEIRLPRAGG--PLGLSIVGGSDHSSHPFGVQE-PGVFISKVLPRGLAARSG-LRV 1054

Query: 212  SDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK----PANQRNNVVRGASGRLTGPP 267
             D IL VNG +V   T  +    ++     L + V+    P   R   ++ A G   G  
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGIS 1114

Query: 268  SAGPGPAEPDSDDDSSD 284
              G       +  D +D
Sbjct: 1115 IRGGARGHAGNPRDPTD 1131



 Score = 34.3 bits (77), Expect = 0.17
 Identities = 43/172 (25%), Positives = 66/172 (38%), Gaps = 7/172 (4%)

Query: 141  QVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRG 200
            ++S ++  D  P   R + + K   +R LG  IR G              GIFIS++   
Sbjct: 1084 ELSLLVRRDPAPPGLRELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPT 1142

Query: 201  GLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNN--VVRG 258
            G A   G L V   +LEVN   + G T  +   ++ +    L V V    + +    +  
Sbjct: 1143 GAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEV 1202

Query: 259  ASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPG 310
            + G +  P +AG G         S    I+    P   G  +  P   LH G
Sbjct: 1203 SPGVIANPFAAGIGHRNSLESISS----IDRELSPEGPGKEKELPGQTLHWG 1250



 Score = 32.0 bits (71), Expect = 0.84
 Identities = 17/35 (48%), Positives = 23/35 (65%), Gaps = 1/35 (2%)

Query: 191 GIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAG 225
           GIFISR+   G A   G+  V D++LEVNG+ + G
Sbjct: 757 GIFISRVSEEGPAARAGV-RVGDKLLEVNGVALQG 790


>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
          Length = 637

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 22/64 (34%), Positives = 38/64 (59%)

Query: 187 ERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTV 246
           E    I ++R++ GGLAE +GLL   D+++EVNG+ V G   +QV  ++  +   ++  V
Sbjct: 172 EMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231

Query: 247 KPAN 250
            P +
Sbjct: 232 VPVS 235


>gi|41281808 harmonin isoform b3 [Homo sapiens]
          Length = 899

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 24/117 (20%)

Query: 119 LRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMS 178
           +RP+ PL+ +       P+  R++  V          R  RLH  G           G+S
Sbjct: 62  IRPLIPLKHQVEYDQLTPRRSRKLKEV----------RLDRLHPEGL----------GLS 101

Query: 179 VRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
           VR    GLE   G+FIS L++GG A+S G L V DEI+ +NG  ++  T ++V +++
Sbjct: 102 VR---GGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLI 154



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 20/63 (31%), Positives = 37/63 (58%), Gaps = 2/63 (3%)

Query: 190 PGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPA 249
           PGIFIS +  G L+   G L + D+I+EVNG++ +     +  +++  +S +L +++  A
Sbjct: 234 PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVL-KSSRSLTISIVAA 291

Query: 250 NQR 252
             R
Sbjct: 292 AGR 294


>gi|71480164 harmonin isoform a [Homo sapiens]
          Length = 552

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 38/117 (32%), Positives = 59/117 (50%), Gaps = 24/117 (20%)

Query: 119 LRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMS 178
           +RP+ PL+ +       P+  R++  V          R  RLH  G           G+S
Sbjct: 62  IRPLIPLKHQVEYDQLTPRRSRKLKEV----------RLDRLHPEGL----------GLS 101

Query: 179 VRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
           VR    GLE   G+FIS L++GG A+S G L V DEI+ +NG  ++  T ++V +++
Sbjct: 102 VR---GGLEFGCGLFISHLIKGGQADSVG-LQVGDEIVRINGYSISSCTHEEVINLI 154



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 20/63 (31%), Positives = 37/63 (58%), Gaps = 2/63 (3%)

Query: 190 PGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPA 249
           PGIFIS +  G L+   G L + D+I+EVNG++ +     +  +++  +S +L +++  A
Sbjct: 234 PGIFISHVKPGSLSAEVG-LEIGDQIVEVNGVDFSNLDHKEAVNVL-KSSRSLTISIVAA 291

Query: 250 NQR 252
             R
Sbjct: 292 AGR 294


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 30/116 (25%), Positives = 58/116 (50%), Gaps = 11/116 (9%)

Query: 138  DFRQVSSVIDVDLLPETHRRVRLHKHGSDRP-----------LGFYIRDGMSVRVAPQGL 186
            D R+ +    +++L +T +RVRL  +  + P           +    + G  + ++  G 
Sbjct: 1684 DLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK 1743

Query: 187  ERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNL 242
                G+F+S +V+GG+A++ G L   D+IL VNG +V   T + V  ++  +  +L
Sbjct: 1744 RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSL 1799



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 27/137 (19%), Positives = 58/137 (42%), Gaps = 3/137 (2%)

Query: 176  GMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            G+ + ++ +  + + G+ I  L   G+A + G L V D+IL V+   V G  +++   ++
Sbjct: 1492 GLGIAISEE--DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549

Query: 236  VANSHNLIVTVKPANQRNNVVRGASGRLTG-PPSAGPGPAEPDSDDDSSDLVIENRQPPS 294
                  + +T+   N  +  V  A+G  +G   ++      P S     + +    +  +
Sbjct: 1550 KTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSST 1609

Query: 295  SNGLSQGPPCWDLHPGC 311
                +  P    + PGC
Sbjct: 1610 PAIFASDPATCPIIPGC 1626



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 19/83 (22%), Positives = 39/83 (46%), Gaps = 9/83 (10%)

Query: 188 RVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK 247
           +  G+ +  ++ GG+A+  G L   D IL++   ++AG + +QV  ++    + +     
Sbjct: 275 KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRV----- 329

Query: 248 PANQRNNVVRGASGRLTGPPSAG 270
               +  + RGA    T P + G
Sbjct: 330 ----KLMIARGAIEERTAPTALG 348



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 13/56 (23%), Positives = 29/56 (51%)

Query: 191 GIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTV 246
           GIF+  + +    E  G + + D+I+ V+G  + G T  Q  +++      +++T+
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTL 459



 Score = 33.1 bits (74), Expect = 0.38
 Identities = 35/156 (22%), Positives = 65/156 (41%), Gaps = 17/156 (10%)

Query: 156  RRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEI 215
            RRV L +  S + LG  I  G  +       E + GIFI  ++    A   G L   D I
Sbjct: 1150 RRVELWREPS-KSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRI 1208

Query: 216  LEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQR----------NNVVRGASGRLTG 265
            +EV+G+++   + +Q  + +    + ++  V+    R          +N+    +   T 
Sbjct: 1209 VEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTN 1268

Query: 266  P------PSAGPGPAEPDSDDDSSDLVIENRQPPSS 295
            P       +A   P++ +S+ + + L      PPS+
Sbjct: 1269 PFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSA 1304



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 18/62 (29%), Positives = 30/62 (48%)

Query: 174  RDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTD 233
            R G+ + +       +  I I  +   G A   G L   D+ILEVNGI++   T D+  +
Sbjct: 1636 RTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAIN 1695

Query: 234  MM 235
            ++
Sbjct: 1696 VL 1697



 Score = 30.4 bits (67), Expect = 2.4
 Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 10/77 (12%)

Query: 191 GIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPAN 250
           GIF+  +  G +A   G L  +D+IL +NG         Q  D  + +   + +  K  +
Sbjct: 164 GIFVQEIQEGSVAHRDGRLKETDQILAING---------QALDQTITHQQAISILQKAKD 214

Query: 251 QRNNVV-RGASGRLTGP 266
               V+ RG+  +L  P
Sbjct: 215 TVQLVIARGSLPQLVSP 231



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 8/93 (8%)

Query: 143  SSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGL 202
            SS+   DL P   + + L + G D  LGF I  G     +P G   +P I++  +   G 
Sbjct: 1944 SSIFQDDLGPPQCKSITLER-GPDG-LGFSIVGGYG---SPHG--DLP-IYVKTVFAKGA 1995

Query: 203  AESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            A   G L   D+I+ VNG  + G T ++   ++
Sbjct: 1996 ASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAIL 2028



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 15/43 (34%), Positives = 24/43 (55%)

Query: 193 FISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
           FI  ++  G    +G L   DE+LEVNGI + G+    V +++
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNIL 619



 Score = 28.5 bits (62), Expect = 9.2
 Identities = 13/36 (36%), Positives = 22/36 (61%)

Query: 192  IFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKT 227
            +FI  +   G A   G L ++DE+LE+NG  + G++
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410


>gi|186700629 calcium/calmodulin-dependent serine protein kinase
           isoform 3 [Homo sapiens]
          Length = 897

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 11/111 (9%)

Query: 125 LRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQ 184
           LR  PP            S+  D+D+   T  R+   +  +D P+G  ++          
Sbjct: 451 LRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK---------- 500

Query: 185 GLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            +  +    ++R++ GG+    G L V DEI E+NGI VA +T++Q+  M+
Sbjct: 501 -MNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKML 550


>gi|186700627 calcium/calmodulin-dependent serine protein kinase
           isoform 2 [Homo sapiens]
          Length = 898

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 11/111 (9%)

Query: 125 LRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQ 184
           LR  PP            S+  D+D+   T  R+   +  +D P+G  ++          
Sbjct: 457 LRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK---------- 506

Query: 185 GLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            +  +    ++R++ GG+    G L V DEI E+NGI VA +T++Q+  M+
Sbjct: 507 -MNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKML 556


>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
          Length = 576

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 29/105 (27%), Positives = 55/105 (52%), Gaps = 12/105 (11%)

Query: 147 DVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAEST 206
           D+D   ++ + +RL K+    PLG  I+            E+   I ++R++RGG A+ +
Sbjct: 129 DIDDEEDSVKIIRLVKNRE--PLGATIKKD----------EQTGAIIVARIMRGGAADRS 176

Query: 207 GLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQ 251
           GL+ V DE+ EVNGI V  K  +++  ++  +   +   + P ++
Sbjct: 177 GLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSK 221


>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
          Length = 690

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 38/134 (28%), Positives = 61/134 (45%), Gaps = 14/134 (10%)

Query: 157 RVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEIL 216
           +V LHK  S   LG  +     VR   +     PG+FI  L+ GGLA   G L+ +D +L
Sbjct: 339 QVALHKRDSGEQLGIKL-----VRRTDE-----PGVFILDLLEGGLAAQDGRLSSNDRVL 388

Query: 217 EVNGIEVAGKTLDQVTDMMVANSHNLIVTV-KPAN-QRNNVVRGASGRLTGPPSAGPGP- 273
            +NG ++   T +    ++ A+   + +T+ +P   Q  N +R A    +      P P 
Sbjct: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPY 448

Query: 274 -AEPDSDDDSSDLV 286
            + P S  D +  V
Sbjct: 449 YSRPSSHKDLTQCV 462


>gi|13376349 PDZ domain containing 7 [Homo sapiens]
          Length = 517

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 23/152 (15%)

Query: 92  VQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPL----LISLPQDFRQVSSVID 147
           +  R    S   + A+  L R+++ LL  P   +R   P+    LI+ P +     S   
Sbjct: 25  LSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDES--- 81

Query: 148 VDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTG 207
            D++      VR+ K  + R LGF +R G     +  GL    GIF+S++  G  AE  G
Sbjct: 82  -DII----HSVRVEKSPAGR-LGFSVRGG-----SEHGL----GIFVSKVEEGSSAERAG 126

Query: 208 LLAVSDEILEVNGIEVAGKTLDQVTDMMVANS 239
           L  V D+I EVNG+ +   T+     ++ ++S
Sbjct: 127 L-CVGDKITEVNGLSLESTTMGSAVKVLTSSS 157



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 11/92 (11%)

Query: 156 RRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEI 215
           R V L+    D  LGF IR G    +         GI++S++  GGLAE  G + V D++
Sbjct: 209 RIVHLYTTSDDFCLGFNIRGGKEFGL---------GIYVSKVDHGGLAEENG-IKVGDQV 258

Query: 216 LEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK 247
           L  NG+     +  Q  +++   +H +++T+K
Sbjct: 259 LAANGVRFDDISHSQAVEVLKGQTH-IMLTIK 289


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 51/166 (30%), Positives = 68/166 (40%), Gaps = 24/166 (14%)

Query: 143 SSVIDVDLLPETH-----RRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRL 197
           SS ++   LPET        V L   GS   LGF I  G           +  G+ +  +
Sbjct: 229 SSSLNDTTLPETVCWGHVEEVELINDGSG--LGFGIVGG-----------KTSGVVVRTI 275

Query: 198 VRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM--VANSHNLIVTVKPANQRNNV 255
           V GGLA+  G L   D IL++ G  V G T +QV  ++    NS  ++V   PA    +V
Sbjct: 276 VPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGD-ISV 334

Query: 256 VRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQG 301
              A   L   P A P  A      DSS     N +    +G S G
Sbjct: 335 TPPAPAAL---PVALPTVASKGPGSDSSLFETYNVELVRKDGQSLG 377



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 11/109 (10%)

Query: 138  DFRQVSSVIDVDLLPETHRRVRL-----HKHGSDR------PLGFYIRDGMSVRVAPQGL 186
            D R  S    +  L +T ++VRL       H  D       P+    + G  + ++  G 
Sbjct: 1492 DLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK 1551

Query: 187  ERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
                G+FIS +V+GG A+  G L   D+IL VNG ++   + + V  ++
Sbjct: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 17/35 (48%), Positives = 26/35 (74%)

Query: 193 FISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKT 227
           +IS +V GG  ++ GLL   DE+LEVNG+++ GK+
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKS 616



 Score = 36.2 bits (82), Expect = 0.044
 Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 1/78 (1%)

Query: 169  LGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTL 228
            LG  I  G +V    +  E + GIFI +++    A  T  L   D+ILEV+G+++   + 
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138

Query: 229  DQVTDMMVANSHNLIVTV 246
             +  +  + N+ N +V +
Sbjct: 1139 SEAVE-AIKNAGNPVVFI 1155



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 24/104 (23%), Positives = 49/104 (47%), Gaps = 19/104 (18%)

Query: 191 GIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPAN 250
           GI++  ++ G  A   G + V+D+I+ V+G+ + G             +H+++  ++ A 
Sbjct: 394 GIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFA-----------NHDVVEVLRNAG 442

Query: 251 QRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPS 294
           Q  ++       +    S+   P EP SD  +   V+E  +PP+
Sbjct: 443 QVVHLT-----LVRRKTSSSTSPLEPPSDRGT---VVEPLKPPA 478



 Score = 31.2 bits (69), Expect = 1.4
 Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 156  RRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEI 215
            R V +++  SD  LG  I  G   R +P G   +P +FI+ +   G+A  T  L V D I
Sbjct: 1675 RTVEINRELSDA-LGISIAGG---RGSPLG--DIP-VFIAMIQASGVAARTQKLKVGDRI 1727

Query: 216  LEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAE 275
            + +NG  + G +   V +++  N++  I+    A+   + +      ++     G   AE
Sbjct: 1728 VSINGQPLDGLSHADVVNLL-KNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAE 1786

Query: 276  PDSDDDSSDL 285
               +D    L
Sbjct: 1787 HHPEDTEEQL 1796



 Score = 28.9 bits (63), Expect = 7.1
 Identities = 34/178 (19%), Positives = 76/178 (42%), Gaps = 10/178 (5%)

Query: 127  TRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYI------RDGMSVR 180
            T PP +  LP  ++ ++   D +   +     ++ +  +D P   +I      ++G+ + 
Sbjct: 1194 TAPPPM-KLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLS 1252

Query: 181  VAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM-VANS 239
            +A         IF+  +   G A + G + + DE+LE+N   + G++    + ++  A S
Sbjct: 1253 LAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312

Query: 240  HNLIVTVKPANQRNNVVRGASGRLTGPPSA--GPGPAEPDSDDDSSDLVIENRQPPSS 295
               +V ++  +  N +        +  PS+       EP S ++   + +  +Q P S
Sbjct: 1313 KVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPES 1370


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 33/132 (25%), Positives = 60/132 (45%), Gaps = 12/132 (9%)

Query: 155  HRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPG------IFISRLVRGGLAESTGL 208
            H R+++ +   D  +     +G+ +R+   G + +PG       +I++++ GG AE TG 
Sbjct: 4494 HARIKITRDSKDHTVS---GNGLGIRIV--GGKEIPGHSGEIGAYIAKILPGGSAEQTGK 4548

Query: 209  LAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK-PANQRNNVVRGASGRLTGPP 267
            L    ++LE NGI +  KT ++V  ++   S    + V+   N  ++        L  PP
Sbjct: 4549 LMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPP 4608

Query: 268  SAGPGPAEPDSD 279
             A      P  D
Sbjct: 4609 KAVDKAKSPGVD 4620


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 33/132 (25%), Positives = 60/132 (45%), Gaps = 12/132 (9%)

Query: 155  HRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPG------IFISRLVRGGLAESTGL 208
            H R+++ +   D  +     +G+ +R+   G + +PG       +I++++ GG AE TG 
Sbjct: 4494 HARIKITRDSKDHTVS---GNGLGIRIV--GGKEIPGHSGEIGAYIAKILPGGSAEQTGK 4548

Query: 209  LAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK-PANQRNNVVRGASGRLTGPP 267
            L    ++LE NGI +  KT ++V  ++   S    + V+   N  ++        L  PP
Sbjct: 4549 LMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPP 4608

Query: 268  SAGPGPAEPDSD 279
             A      P  D
Sbjct: 4609 KAVDKAKSPGVD 4620


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 28/86 (32%), Positives = 46/86 (53%), Gaps = 11/86 (12%)

Query: 165 SDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVA 224
           +D  LGF +  G          E+   I+ISR++ GG+AE  G L   D++L VNG+ V 
Sbjct: 114 TDEGLGFNVMGGK---------EQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVE 164

Query: 225 GKTLDQVTDMMVA--NSHNLIVTVKP 248
           G+  ++  +++ A  +S  L+V   P
Sbjct: 165 GEHHEKAVELLKAAKDSVKLVVRYTP 190


>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 1 [Homo
            sapiens]
          Length = 1834

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 2/76 (2%)

Query: 176  GMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            G+S+  A    +   GI++  +V+GG A+  G LA  D++L V+G  + G + ++  ++M
Sbjct: 1018 GLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELM 1077

Query: 236  VANSHNLIVTVKPANQ 251
               S   +VT++ A Q
Sbjct: 1078 TRTSS--VVTLEVAKQ 1091


>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 2 [Homo
            sapiens]
          Length = 1651

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 2/76 (2%)

Query: 176  GMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            G+S+  A    +   GI++  +V+GG A+  G LA  D++L V+G  + G + ++  ++M
Sbjct: 1019 GLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELM 1078

Query: 236  VANSHNLIVTVKPANQ 251
               S   +VT++ A Q
Sbjct: 1079 TRTSS--VVTLEVAKQ 1092


>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 3 [Homo
            sapiens]
          Length = 1612

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 2/76 (2%)

Query: 176  GMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
            G+S+  A    +   GI++  +V+GG A+  G LA  D++L V+G  + G + ++  ++M
Sbjct: 1003 GLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELM 1062

Query: 236  VANSHNLIVTVKPANQ 251
               S   +VT++ A Q
Sbjct: 1063 TRTSS--VVTLEVAKQ 1076


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 11/110 (10%)

Query: 176 GMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMM 235
           G+S++    G E    + IS++     A+ TG+L V D +L+VNGI V   T ++V  ++
Sbjct: 85  GLSIK---GGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLL 141

Query: 236 VANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDL 285
                 + +TV+   +    ++         P   PGP+   S   SS L
Sbjct: 142 RNAGDEVTITVEYLREAPAFLK--------LPLGSPGPSSDHSSGASSPL 183


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 30/168 (17%)

Query: 169 LGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTL 228
           LGF +++ +S           P + IS L+RGG AE +GL+   D IL VNG  +   + 
Sbjct: 28  LGFLVKERVSK----------PPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSY 77

Query: 229 DQVTDMM--VANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLV 286
           D   +++  +A+  ++++          ++RG  G  T   +   G   P +   +  L 
Sbjct: 78  DSALEVLRGIASETHVVL----------ILRGPEGFTTHLETTFTGDGTPKTIRVTQPL- 126

Query: 287 IENRQPPSSNGLSQGPPCWDLHP----GCRHPGTRSSLPSLDDQEQAS 330
                P  +  LS  PP     P    G   PG        D QE  S
Sbjct: 127 ---GPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGS 171


>gi|21361142 PDZ domain containing 1 [Homo sapiens]
          Length = 519

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 46/184 (25%), Positives = 79/184 (42%), Gaps = 23/184 (12%)

Query: 65  HGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPV-- 122
           +G+ +   + DS+   +  G     LLV  +   +   LA  S  L  + + L    V  
Sbjct: 292 NGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKE 351

Query: 123 APLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVA 182
           AP  T   L +S P D  +     +VD  P+  R  +      +   GF++         
Sbjct: 352 APAPTPTSLEVSSPPDTTE-----EVDHKPKLCRLAK-----GENGYGFHLN-------- 393

Query: 183 PQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNL 242
              +  +PG FI  + +GG A+  GL    D I+EVNG+ V  +  ++V D + ++  N+
Sbjct: 394 --AIRGLPGSFIKEVQKGGPADLAGL-EDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNV 450

Query: 243 IVTV 246
            + V
Sbjct: 451 TLLV 454



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 16/65 (24%), Positives = 37/65 (56%), Gaps = 1/65 (1%)

Query: 169 LGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTL 228
           L + +++G S   + + ++   G++++ +   G+A   G+LA  D ++EVNG  V   + 
Sbjct: 135 LCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLA-DDHLIEVNGENVEDASH 193

Query: 229 DQVTD 233
           ++V +
Sbjct: 194 EEVVE 198


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 28/86 (32%), Positives = 45/86 (52%), Gaps = 11/86 (12%)

Query: 165 SDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVA 224
           +D  LGF I  G          E+   I+ISR++ GG+A+  G L   D++L VNG+ V 
Sbjct: 99  TDEGLGFNIMGGK---------EQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149

Query: 225 GKTLDQVTDMMVA--NSHNLIVTVKP 248
           G+  ++  +++ A   S  L+V   P
Sbjct: 150 GEQHEKAVELLKAAQGSVKLVVRYTP 175


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 30/118 (25%), Positives = 48/118 (40%), Gaps = 7/118 (5%)

Query: 192 IFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQ 251
           I IS L +GGLAE TG + + D IL +N   + GK L +   ++      + + +K    
Sbjct: 645 IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIK---- 700

Query: 252 RNNVVRGASGRLTGPPS---AGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWD 306
           +    + AS     P S   +  G  E DS        + +  P +   +      WD
Sbjct: 701 KQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWD 758



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 16/54 (29%), Positives = 29/54 (53%)

Query: 194 ISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK 247
           +S L +GG+A  +  L V D I  VNGI +A    D++  ++      +++ V+
Sbjct: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE 133



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 14/54 (25%), Positives = 28/54 (51%)

Query: 194 ISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVK 247
           IS +     AE  G+L + D ++ +NGI     T ++ + ++  +S    VT++
Sbjct: 451 ISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 504


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,306,450
Number of Sequences: 37866
Number of extensions: 797886
Number of successful extensions: 3418
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 3147
Number of HSP's gapped (non-prelim): 335
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.