Search of human proteins with 83722284

Search of human proteins with 83722284

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|83722284 R-spondin family, member 4 isoform 1 precursor
[Homo sapiens]
         (234 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo...   515   e-146
gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo...   313   6e-86
gi|222446611 R-spondin family, member 2 [Homo sapiens]                210   1e-54
gi|18490982 R-spondin 3 [Homo sapiens]                                182   2e-46
gi|84490388 R-spondin1 [Homo sapiens]                                 176   2e-44
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...    60   2e-09
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...    60   2e-09
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...    60   2e-09
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...    60   2e-09
gi|239755070 PREDICTED: similar to proprotein convertase subtili...    58   6e-09
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ...    58   6e-09
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ...    58   6e-09
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          57   2e-08
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...    55   4e-08
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]                43   3e-04
gi|14790170 tumor necrosis factor receptor superfamily, member 6...    41   0.001
gi|4507585 tumor necrosis factor receptor superfamily, member 6b...    41   0.001
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...    40   0.002
gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]          40   0.002
gi|31657140 insulin receptor-related receptor precursor [Homo sa...    39   0.003
gi|4505737 complement factor properdin precursor [Homo sapiens]        39   0.005
gi|145309326 laminin, gamma 1 precursor [Homo sapiens]                 39   0.005
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...    39   0.005
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]    39   0.005
gi|223671861 complement factor properdin precursor [Homo sapiens]      39   0.005
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...    38   0.007
gi|134031945 SCO-spondin [Homo sapiens]                                38   0.007
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ...    38   0.009
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]    38   0.009
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ...    37   0.011

>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
           sapiens]
          Length = 234

 Score =  515 bits (1326), Expect = e-146
 Identities = 234/234 (100%), Positives = 234/234 (100%)

Query: 1   MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
           MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
Sbjct: 1   MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60

Query: 61  EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
           EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
Sbjct: 61  EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120

Query: 121 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT 180
           TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
Sbjct: 121 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT 180

Query: 181 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 234
           CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
Sbjct: 181 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 234


>gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo
           sapiens]
          Length = 172

 Score =  313 bits (803), Expect = 6e-86
 Identities = 161/234 (68%), Positives = 164/234 (70%), Gaps = 62/234 (26%)

Query: 1   MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60
           MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
Sbjct: 1   MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR 60

Query: 61  EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120
           EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
Sbjct: 61  EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP 120

Query: 121 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT 180
           TCPPGTLAHQNTRECQ                                            
Sbjct: 121 TCPPGTLAHQNTRECQ-------------------------------------------- 136

Query: 181 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP 234
                   + P Q+    +R P     RKD      RKLDRRLDVRPRQPGLQP
Sbjct: 137 -------ERSPGQKKGRKDRRP-----RKD------RKLDRRLDVRPRQPGLQP 172


>gi|222446611 R-spondin family, member 2 [Homo sapiens]
          Length = 243

 Score =  210 bits (534), Expect = 1e-54
 Identities = 94/204 (46%), Positives = 130/204 (63%), Gaps = 6/204 (2%)

Query: 22  RRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIR 81
           RR K+        C GC+ CS++NGCS CQQ+LF F+RREG+RQYG+CLH CP GY+G R
Sbjct: 27  RRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHR 86

Query: 82  GQEVNRCKKCGA-TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE 140
             ++NRC +C    C+SCFS+DFC +CK  FYL++G+C   CP G    + T EC   CE
Sbjct: 87  APDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCE 146

Query: 141 LGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPI-QRPCP-G 198
           +G W  W  C+ N +TCG  WGLE+R R+  +   ++   C  ++ESR+C +  R CP G
Sbjct: 147 VGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGG 206

Query: 199 ERSPGQKKGRKDRRPRKDRKLDRR 222
           +R+P   K ++ R  +K RKL  R
Sbjct: 207 KRTP---KAKEKRNKKKKRKLIER 227


>gi|18490982 R-spondin 3 [Homo sapiens]
          Length = 272

 Score =  182 bits (463), Expect = 2e-46
 Identities = 87/201 (43%), Positives = 123/201 (61%), Gaps = 8/201 (3%)

Query: 22  RRKKQVGTGLGGNCTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGI 80
           RR++++   +   C G C  CS+ NGC +C+ RLF  + R G++Q G CL  CP GY+G 
Sbjct: 28  RRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGT 87

Query: 81  RGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQG--E 138
           R  ++N+C KC A C++CF+++FC +CK  FYL+ GKCL  CP G  A+ +T EC     
Sbjct: 88  RYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVH 147

Query: 139 CELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQR-PC- 196
           CE+  W  WSPCT  GKTCG   G E+RVRE  +    +   C   +E+RKC +QR  C 
Sbjct: 148 CEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQ 207

Query: 197 PGERSPGQKKGRKDRRPRKDR 217
            GER    KKGR+ +R + ++
Sbjct: 208 KGERG---KKGRERKRKKPNK 225


>gi|84490388 R-spondin1 [Homo sapiens]
          Length = 263

 Score =  176 bits (445), Expect = 2e-44
 Identities = 89/232 (38%), Positives = 124/232 (53%), Gaps = 12/232 (5%)

Query: 1   MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL 54
           MR  LC++ LV     +   +R     R++++       C  GC +CSE NGC  C  +L
Sbjct: 1   MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60

Query: 55  FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL 113
           F+ + R  IRQ G CL  CPPGYF  R  ++N+C KC    CE+CFS +FC +CK   YL
Sbjct: 61  FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120

Query: 114 YKGKCLPTCPPGTLAHQNTRECQ--GECELGPWGGWSPCTHNGKTCGSAWGLESRVREAG 171
           +KG+C P CP G+ A   T EC    +CE+  W  W PC+   + CG   G E R R   
Sbjct: 121 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL 180

Query: 172 RAGHEEAATCQVLSESRKCPIQR-PCPGERSPGQKKGRKDRRPRKDRKLDRR 222
            A   + A C    E+R+C ++R PCP      ++KG + RR   +R L R+
Sbjct: 181 HAPVGDHAACSDTKETRRCTVRRVPCP--EGQKRRKGGQGRRENANRNLARK 230


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)

Query: 46  GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
           GC TC  R        R G    ++   C+  CP G++    Q+   C KC  +C+ C  
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 796

Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE------LGPWGGWSPCTHN 153
           + + C  CK  F L +G C+P C PGT        C GEC       +GP  G   C H 
Sbjct: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-GECHHTCGTCVGP--GREECIHC 853

Query: 154 GK 155
            K
Sbjct: 854 AK 855



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 6/72 (8%)

Query: 68  KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCP 123
           KC+  CP GYFG       RC++C   CE+C S+    C+ C+R FY ++    C+  CP
Sbjct: 715 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 772

Query: 124 PGTLAHQNTREC 135
            G  A ++ + C
Sbjct: 773 AGFYADESQKNC 784



 Score = 54.3 bits (129), Expect = 9e-08
 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 16/95 (16%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
           +C  C+   E   C+ C++   L          G C+ DC PG YF     E+ RC +C 
Sbjct: 790 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 836

Query: 93  ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG 125
            TC +C    ++ CI C + F+ +  KC+P C  G
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)

Query: 46  GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
           GC TC  R        R G    ++   C+  CP G++    Q+   C KC  +C+ C  
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 809

Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE------LGPWGGWSPCTHN 153
           + + C  CK  F L +G C+P C PGT        C GEC       +GP  G   C H 
Sbjct: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-GECHHTCGTCVGP--GREECIHC 866

Query: 154 GK 155
            K
Sbjct: 867 AK 868



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 6/72 (8%)

Query: 68  KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCP 123
           KC+  CP GYFG       RC++C   CE+C S+    C+ C+R FY ++    C+  CP
Sbjct: 728 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 785

Query: 124 PGTLAHQNTREC 135
            G  A ++ + C
Sbjct: 786 AGFYADESQKNC 797



 Score = 54.3 bits (129), Expect = 9e-08
 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 16/95 (16%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
           +C  C+   E   C+ C++   L          G C+ DC PG YF     E+ RC +C 
Sbjct: 803 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 849

Query: 93  ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG 125
            TC +C    ++ CI C + F+ +  KC+P C  G
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)

Query: 46  GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
           GC TC  R        R G    ++   C+  CP G++    Q+   C KC  +C+ C  
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 809

Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE------LGPWGGWSPCTHN 153
           + + C  CK  F L +G C+P C PGT        C GEC       +GP  G   C H 
Sbjct: 810 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-GECHHTCGTCVGP--GREECIHC 866

Query: 154 GK 155
            K
Sbjct: 867 AK 868



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 23/116 (19%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
           +C  C+   E   C+ C++   L          G C+ DC PG YF     E+ RC +C 
Sbjct: 803 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 849

Query: 93  ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG-------TLAHQNTRECQGEC 139
            TC +C    ++ CI C + F+ +  KC+P C  G        L H+  R C   C
Sbjct: 850 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENC 905



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 6/72 (8%)

Query: 68  KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCP 123
           KC+  CP GYFG       RC++C   CE+C S+    C+ C+R FY ++    C+  CP
Sbjct: 728 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 785

Query: 124 PGTLAHQNTREC 135
            G  A ++ + C
Sbjct: 786 AGFYADESQKNC 797


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)

Query: 46  GCSTCQQRLFL--FIRREGI---RQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS 100
           GC TC  R        R G    ++   C+  CP G++    Q+   C KC  +C+ C  
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQK--NCLKCHPSCKKCVD 796

Query: 101 Q-DFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECE------LGPWGGWSPCTHN 153
           + + C  CK  F L +G C+P C PGT        C GEC       +GP  G   C H 
Sbjct: 797 EPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC-GECHHTCGTCVGP--GREECIHC 853

Query: 154 GK 155
            K
Sbjct: 854 AK 855



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 35/116 (30%), Positives = 51/116 (43%), Gaps = 23/116 (19%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPG-YFGIRGQEVNRCKKCG 92
           +C  C+   E   C+ C++   L          G C+ DC PG YF     E+ RC +C 
Sbjct: 790 SCKKCV--DEPEKCTVCKEGFSL--------ARGSCIPDCEPGTYFD---SELIRCGECH 836

Query: 93  ATCESCFS--QDFCIRCKRQFYLYKGKCLPTCPPG-------TLAHQNTRECQGEC 139
            TC +C    ++ CI C + F+ +  KC+P C  G        L H+  R C   C
Sbjct: 837 HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENC 892



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 6/72 (8%)

Query: 68  KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCP 123
           KC+  CP GYFG       RC++C   CE+C S+    C+ C+R FY ++    C+  CP
Sbjct: 715 KCVSVCPLGYFG--DTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCP 772

Query: 124 PGTLAHQNTREC 135
            G  A ++ + C
Sbjct: 773 AGFYADESQKNC 784


>gi|239755070 PREDICTED: similar to proprotein convertase
           subtilisin/kexin type 5 [Homo sapiens]
          Length = 853

 Score = 58.2 bits (139), Expect = 6e-09
 Identities = 38/130 (29%), Positives = 56/130 (43%), Gaps = 26/130 (20%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           NC+ C    ++NGC  C++  FL          G C+  C PG++G   QE+  C+ C  
Sbjct: 81  NCSSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126

Query: 94  TCESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCT 151
            CE+C     D C  C+    L +G C+         H    + +G+          PC 
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV---------HATKTQEEGKFWNDILRKLQPCH 177

Query: 152 HNGKTC-GSA 160
            + KTC GSA
Sbjct: 178 SSCKTCNGSA 187



 Score = 57.8 bits (138), Expect = 8e-09
 Identities = 44/170 (25%), Positives = 66/170 (38%), Gaps = 26/170 (15%)

Query: 38  CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C  CS    C TC+         EG  +  +G C  +CP  +  + G     CK C   C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVEGV----CKHCPEMC 323

Query: 96  ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA--------HQNTRECQG----ECELGP 143
           + C  +  C  C  +F+L+   C  +CP G  A        H++  EC G    +CEL  
Sbjct: 324 QDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCL 383

Query: 144 WGGWSPCTHNG---KTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKC 190
              W    ++G   + C +    E + +E  R  H+   TC        C
Sbjct: 384 ESSW--VLYDGLCLEECPAGTYYEKQTKEC-RDCHKSCLTCSSSGTCTTC 430



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 34/106 (32%), Positives = 48/106 (45%), Gaps = 11/106 (10%)

Query: 38  CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
           C  C   + C TC+ R        R G  Q GK CL  C  GY+        RC++C  +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565

Query: 95  CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQ 136
           C+ C       C+ C R F+L   KG+C  +CP      Q+T+ C+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 33/114 (28%), Positives = 43/114 (37%), Gaps = 30/114 (26%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
           C   CP   +     E   CK C + C SC  Q+ C  C+  F+L  G C+  C PG   
Sbjct: 60  CYKTCPEKTYS----EAVECKACDSNCSSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 129 HQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQ 182
            Q      GECE         C    +TC                GH+E ++CQ
Sbjct: 115 DQE----MGECE--------SCHRACETCTG-------------PGHDECSSCQ 143



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 34/132 (25%), Positives = 50/132 (37%), Gaps = 29/132 (21%)

Query: 41  CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
           C   NG    C++C +  +L  +         C+  CP G +  +R      C+ C   C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228

Query: 96  ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE-CQGECELGPWGGWSPC 150
             C   D C +C+ Q     +L++G+C   CP G+ A     E C   C          C
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCR--------TC 280

Query: 151 THNGKTCGSAWG 162
             N   C S  G
Sbjct: 281 EGNATNCHSCEG 292



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)

Query: 38  CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD--CPPGYFGIRGQEVNRCKKCGATC 95
           C+ CS    C+TCQ+ L +  R       G C+ +  C P  +    ++   CK C   C
Sbjct: 418 CLTCSSSGTCTTCQKGLIMNPR-------GSCMANEKCSPSEYW--DEDAPGCKPCHVKC 468

Query: 96  ESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTREC 135
             C   ++D C  C     L    C+  CP G  A +++  C
Sbjct: 469 FHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRC 510



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 33/128 (25%), Positives = 49/128 (38%), Gaps = 27/128 (21%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C GC        C +C +  FL      +R  G+C   CP  Y+    Q    C++C  
Sbjct: 565 SCKGCQ-GPRPTDCLSCDRFFFL------LRSKGECHRSCPDHYYV--EQSTQTCERCHP 615

Query: 94  TCESCFSQDF--CIRCKRQFYLYKGKCLPTCPPGTL------------AHQNTRECQG-- 137
           TC+ C  +    C+ C   ++L  G C   C  G               H++  EC+G  
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPG 675

Query: 138 --ECELGP 143
              C L P
Sbjct: 676 AKNCTLCP 683



 Score = 41.2 bits (95), Expect = 8e-04
 Identities = 39/180 (21%), Positives = 63/180 (35%), Gaps = 36/180 (20%)

Query: 38  CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C+ CS  + + C  C +  ++          G CL +CP G +    ++   C+ C  +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKQTKECRDCHKSC 418

Query: 96  ESCFSQDFCIRCKRQFYLY-KGKCL---------------PTCPPGTLAHQNTRECQG-- 137
            +C S   C  C++   +  +G C+               P C P    H     C G  
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKP---CHVKCFHCMGPA 475

Query: 138 --ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRP 195
             +C+  P       T   K C   +  +          H    TC+    SR+C   RP
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHC-HSSCRTCEG-RHSRQCHSCRP 533



 Score = 32.3 bits (72), Expect = 0.36
 Identities = 36/138 (26%), Positives = 51/138 (36%), Gaps = 26/138 (18%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
           G C  DC  G + +   E   C+KC  +C  C       C  C     L+  +  CL  C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDESHCLHCC 699

Query: 123 ----PPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTC-------------GSA---W- 161
               PP      + ++   EC L       P T + KT              G+A   W 
Sbjct: 700 NTSDPPSAQECCDCQDTTDECILRT-SKVRPATEHFKTALFITSSMMLVLLLGAAVVVWK 758

Query: 162 GLESRVREAGRAGHEEAA 179
               RV+ A +AG+E+ A
Sbjct: 759 KSRGRVQPAAKAGYEKLA 776


>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
           sapiens]
          Length = 853

 Score = 58.2 bits (139), Expect = 6e-09
 Identities = 44/170 (25%), Positives = 66/170 (38%), Gaps = 26/170 (15%)

Query: 38  CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C  CS    C TC+         EG  +  +G C  +CP  +  ++G     CK C   C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGV----CKHCPEMC 323

Query: 96  ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA--------HQNTRECQG----ECELGP 143
           + C  +  C  C  +F+L+   C  +CP G  A        H++  EC G    +CEL  
Sbjct: 324 QDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCL 383

Query: 144 WGGWSPCTHNG---KTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKC 190
              W    ++G   + C +    E   +E  R  H+   TC        C
Sbjct: 384 ESSW--VLYDGLCLEECPAGTYYEKETKEC-RDCHKSCLTCSSSGTCTTC 430



 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 38/130 (29%), Positives = 55/130 (42%), Gaps = 26/130 (20%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           NC  C    ++NGC  C++  FL          G C+  C PG++G   QE+  C+ C  
Sbjct: 81  NCGSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126

Query: 94  TCESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCT 151
            CE+C     D C  C+    L +G C+         H    + +G+          PC 
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV---------HATKTQEEGKFWNDILRKLQPCH 177

Query: 152 HNGKTC-GSA 160
            + KTC GSA
Sbjct: 178 SSCKTCNGSA 187



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 34/106 (32%), Positives = 48/106 (45%), Gaps = 11/106 (10%)

Query: 38  CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
           C  C   + C TC+ R        R G  Q GK CL  C  GY+        RC++C  +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565

Query: 95  CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQ 136
           C+ C       C+ C R F+L   KG+C  +CP      Q+T+ C+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 34/132 (25%), Positives = 50/132 (37%), Gaps = 29/132 (21%)

Query: 41  CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
           C   NG    C++C +  +L  +         C+  CP G +  +R      C+ C   C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228

Query: 96  ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE-CQGECELGPWGGWSPC 150
             C   D C +C+ Q     +L++G+C   CP G+ A     E C   C          C
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCR--------TC 280

Query: 151 THNGKTCGSAWG 162
             N   C S  G
Sbjct: 281 EGNATNCHSCEG 292



 Score = 48.5 bits (114), Expect = 5e-06
 Identities = 33/114 (28%), Positives = 43/114 (37%), Gaps = 30/114 (26%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
           C   CP   +     E   CK C + C SC  Q+ C  C+  F+L  G C+  C PG   
Sbjct: 60  CYKTCPEKTYS----EAVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 129 HQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQ 182
            Q      GECE         C    +TC                GH+E ++CQ
Sbjct: 115 DQE----MGECE--------SCHRACETCTG-------------PGHDECSSCQ 143



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 33/128 (25%), Positives = 49/128 (38%), Gaps = 27/128 (21%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C GC        C +C +  FL      +R  G+C   CP  Y+    Q    C++C  
Sbjct: 565 SCKGCQ-GPRPTDCLSCDRFFFL------LRSKGECHRSCPDHYYV--EQSTQTCERCHP 615

Query: 94  TCESCFSQDF--CIRCKRQFYLYKGKCLPTCPPGTL------------AHQNTRECQG-- 137
           TC+ C  +    C+ C   ++L  G C   C  G               H++  EC+G  
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPG 675

Query: 138 --ECELGP 143
              C L P
Sbjct: 676 AKNCTLCP 683



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 40/180 (22%), Positives = 63/180 (35%), Gaps = 36/180 (20%)

Query: 38  CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C+ CS  + + C  C +  ++          G CL +CP G +    +E   C+ C  +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKETKECRDCHKSC 418

Query: 96  ESCFSQDFCIRCKRQFYLY-KGKCL---------------PTCPPGTLAHQNTRECQG-- 137
            +C S   C  C++   +  +G C+               P C P    H     C G  
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKP---CHVKCFHCMGPA 475

Query: 138 --ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRP 195
             +C+  P       T   K C   +  +          H    TC+    SR+C   RP
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHC-HSSCRTCEG-RHSRQCHSCRP 533



 Score = 31.6 bits (70), Expect = 0.61
 Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 26/138 (18%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
           G C  DC  G + +   E   C+KC  +C  C       C  C     L+     CL  C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCC 699

Query: 123 ----PPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTC-------------GSA---W- 161
               PP      + ++   EC L       P T + KT              G+A   W 
Sbjct: 700 NTSDPPSAQECCDCQDTTDECILRT-SKVRPATEHFKTALFITSSMMLVLLLGAAVVVWK 758

Query: 162 GLESRVREAGRAGHEEAA 179
               RV+ A +AG+E+ A
Sbjct: 759 KSRGRVQPAAKAGYEKLA 776


>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
           sapiens]
          Length = 853

 Score = 58.2 bits (139), Expect = 6e-09
 Identities = 44/170 (25%), Positives = 66/170 (38%), Gaps = 26/170 (15%)

Query: 38  CIICSEENGCSTCQQRLFLFIRREG--IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C  CS    C TC+         EG  +  +G C  +CP  +  ++G     CK C   C
Sbjct: 270 CERCSSP--CRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGV----CKHCPEMC 323

Query: 96  ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA--------HQNTRECQG----ECELGP 143
           + C  +  C  C  +F+L+   C  +CP G  A        H++  EC G    +CEL  
Sbjct: 324 QDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCL 383

Query: 144 WGGWSPCTHNG---KTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKC 190
              W    ++G   + C +    E   +E  R  H+   TC        C
Sbjct: 384 ESSW--VLYDGLCLEECPAGTYYEKETKEC-RDCHKSCLTCSSSGTCTTC 430



 Score = 57.0 bits (136), Expect = 1e-08
 Identities = 38/130 (29%), Positives = 55/130 (42%), Gaps = 26/130 (20%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           NC  C    ++NGC  C++  FL          G C+  C PG++G   QE+  C+ C  
Sbjct: 81  NCGSC----DQNGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESCHR 126

Query: 94  TCESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCT 151
            CE+C     D C  C+    L +G C+         H    + +G+          PC 
Sbjct: 127 ACETCTGPGHDECSSCQEGLQLLRGMCV---------HATKTQEEGKFWNDILRKLQPCH 177

Query: 152 HNGKTC-GSA 160
            + KTC GSA
Sbjct: 178 SSCKTCNGSA 187



 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 34/106 (32%), Positives = 48/106 (45%), Gaps = 11/106 (10%)

Query: 38  CIICSEENGCSTCQQRLFLFIR--REGIRQYGK-CLHDCPPGYFGIRGQEVNRCKKCGAT 94
           C  C   + C TC+ R        R G  Q GK CL  C  GY+        RC++C  +
Sbjct: 510 CAHC--HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYA--DNSTGRCERCNRS 565

Query: 95  CESCFSQ--DFCIRCKRQFYLY--KGKCLPTCPPGTLAHQNTRECQ 136
           C+ C       C+ C R F+L   KG+C  +CP      Q+T+ C+
Sbjct: 566 CKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCE 611



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 34/132 (25%), Positives = 50/132 (37%), Gaps = 29/132 (21%)

Query: 41  CSEENG----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYF-GIRGQEVNRCKKCGATC 95
           C   NG    C++C +  +L  +         C+  CP G +  +R      C+ C   C
Sbjct: 180 CKTCNGSATLCTSCPKGAYLLAQA--------CVSSCPQGTWPSVRS---GSCENCTEAC 228

Query: 96  ESCFSQDFCIRCKRQ----FYLYKGKCLPTCPPGTLAHQNTRE-CQGECELGPWGGWSPC 150
             C   D C +C+ Q     +L++G+C   CP G+ A     E C   C          C
Sbjct: 229 AICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCR--------TC 280

Query: 151 THNGKTCGSAWG 162
             N   C S  G
Sbjct: 281 EGNATNCHSCEG 292



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 33/114 (28%), Positives = 43/114 (37%), Gaps = 30/114 (26%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
           C   CP   +     E   CK C + C SC  Q+ C  C+  F+L  G C+  C PG   
Sbjct: 60  CYKTCPEKTYS----EEVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPGFYG 114

Query: 129 HQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQ 182
            Q      GECE         C    +TC                GH+E ++CQ
Sbjct: 115 DQE----MGECE--------SCHRACETCTG-------------PGHDECSSCQ 143



 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 33/128 (25%), Positives = 49/128 (38%), Gaps = 27/128 (21%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C GC        C +C +  FL      +R  G+C   CP  Y+    Q    C++C  
Sbjct: 565 SCKGCQ-GPRPTDCLSCDRFFFL------LRSKGECHRSCPDHYYV--EQSTQTCERCHP 615

Query: 94  TCESCFSQDF--CIRCKRQFYLYKGKCLPTCPPGTL------------AHQNTRECQG-- 137
           TC+ C  +    C+ C   ++L  G C   C  G               H++  EC+G  
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPG 675

Query: 138 --ECELGP 143
              C L P
Sbjct: 676 AKNCTLCP 683



 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 40/180 (22%), Positives = 63/180 (35%), Gaps = 36/180 (20%)

Query: 38  CIICS--EENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC 95
           C+ CS  + + C  C +  ++          G CL +CP G +    +E   C+ C  +C
Sbjct: 368 CLECSGPKADDCELCLESSWVLYD-------GLCLEECPAGTY--YEKETKECRDCHKSC 418

Query: 96  ESCFSQDFCIRCKRQFYLY-KGKCL---------------PTCPPGTLAHQNTRECQG-- 137
            +C S   C  C++   +  +G C+               P C P    H     C G  
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKP---CHVKCFHCMGPA 475

Query: 138 --ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRP 195
             +C+  P       T   K C   +  +          H    TC+    SR+C   RP
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHC-HSSCRTCEG-RHSRQCHSCRP 533



 Score = 31.6 bits (70), Expect = 0.61
 Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 26/138 (18%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDF--CIRCKRQFYLY--KGKCLPTC 122
           G C  DC  G + +   E   C+KC  +C  C       C  C     L+     CL  C
Sbjct: 640 GICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCC 699

Query: 123 ----PPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTC-------------GSA---W- 161
               PP      + ++   EC L       P T + KT              G+A   W 
Sbjct: 700 NTSDPPSAQECCDCQDTTDECILRT-SKVRPATEHFKTALFITSSMMLVLLLGAAVVVWK 758

Query: 162 GLESRVREAGRAGHEEAA 179
               RV+ A +AG+E+ A
Sbjct: 759 KSRGRVQPAAKAGYEKLA 776


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 27/101 (26%), Positives = 42/101 (41%), Gaps = 10/101 (9%)

Query: 38   CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
            C+ C   + C+ C+    L           +C+ +C  GYF    +  ++C  C   C  
Sbjct: 1008 CLQCQGPHECTRCKGPFLLL--------EAQCVQECGKGYFADHAK--HKCTACPQGCLQ 1057

Query: 98   CFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGE 138
            C  +D C  C   F+L  G C+  C PG   H +   C G+
Sbjct: 1058 CSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGK 1098



 Score = 54.7 bits (130), Expect = 7e-08
 Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 19/115 (16%)

Query: 33  GNCTGCIICSEENG-----CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNR 87
           G C+ C    +  G     C TC ++  L          GKC+ +CP GY+        R
Sbjct: 556 GTCSACDQSCDSCGPSSPRCLTCTEKTVL--------HDGKCMSECPGGYY---ADATGR 604

Query: 88  CKKCGATCESCF--SQDFCIRCKRQFYLYKGKCLPTCPPGTLA-HQNTRECQGEC 139
           CK C  +C SC   +   C  C     L +G CLP C  G  + H   + C   C
Sbjct: 605 CKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSC 659



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 41/157 (26%), Positives = 59/157 (37%), Gaps = 24/157 (15%)

Query: 38  CIICSEE-NGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCE 96
           C+ CS+  + C  CQ    L        Q G C+H C  G++    Q  + C  C   C 
Sbjct: 425 CLTCSQSPDHCDLCQDPTKLL-------QNGWCVHSCGLGFY----QAGSLCLACQPQCS 473

Query: 97  SCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKT 156
           +C S   C  C+    +  G+C+PTC  G   +Q+   C   C     G W P   +   
Sbjct: 474 TCTSGLECSSCQPPLLMRHGQCVPTCGDG--FYQDRHSC-AVCHESCAGCWGPTEKHCLA 530

Query: 157 CGSA------WGLESRVREAGRAGHEEAATCQVLSES 187
           C          G ES     G+  +    TC    +S
Sbjct: 531 CRDPLHVLRDGGCES---SCGKGFYNRQGTCSACDQS 564



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 15/109 (13%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C GC   +E++ C  C+  L +        + G C   C  G++  +G     C  C  
Sbjct: 516 SCAGCWGPTEKH-CLACRDPLHVL-------RDGGCESSCGKGFYNRQGT----CSACDQ 563

Query: 94  TCESCF-SQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTR--ECQGEC 139
           +C+SC  S   C+ C  +  L+ GKC+  CP G  A    R   C   C
Sbjct: 564 SCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSC 612



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 36/124 (29%), Positives = 47/124 (37%), Gaps = 20/124 (16%)

Query: 35  CTGCIICSEENG--CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCG 92
           C  C       G  C  CQ   +L +          C+ DCP GY+  RG     CKKC 
Sbjct: 813 CQHCAADLHNTGSICLRCQNAHYLLLGDH-------CVPDCPSGYYAERG----ACKKCH 861

Query: 93  ATCESCFSQD--FCIRCKRQFYL-YKGKCLPTCPPGTLAHQN--TRECQGECELGPWGGW 147
           ++C +C  +    C  C     L + G C  TC PG     N   + C   C  G     
Sbjct: 862 SSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQPCNTHC--GSCDSQ 919

Query: 148 SPCT 151
           + CT
Sbjct: 920 ASCT 923



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 21/58 (36%), Positives = 25/58 (43%), Gaps = 6/58 (10%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFS--QDFCIRCKRQFYLYKGKCLPTC 122
           G+CL  CP GYF   G     C +C  TC  C    +  CI C     L  G C  +C
Sbjct: 741 GQCLSQCPDGYFHQEGS----CTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSC 794



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 12/107 (11%)

Query: 36   TGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD-CPPGYFGIRGQEVNRCKKCGAT 94
            T C  C  +  C++C+    + +       +G+C ++ C P Y+       N CK+C  +
Sbjct: 911  THCGSCDSQASCTSCRDPNKVLL-------FGECQYESCAPQYY--LDFSTNTCKECDWS 961

Query: 95   CESCFS--QDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGEC 139
            C +C    +  C++C   + L  G C+  C           +C   C
Sbjct: 962  CSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYC 1008



 Score = 41.2 bits (95), Expect = 8e-04
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 5/73 (6%)

Query: 63   IRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTC 122
            + Q G C+  C   ++    Q+   CK C + C  C     C RCK  F L + +C+  C
Sbjct: 981  VLQDGACVEQCLSSFY----QDSGLCK-CDSYCLQCQGPHECTRCKGPFLLLEAQCVQEC 1035

Query: 123  PPGTLAHQNTREC 135
              G  A     +C
Sbjct: 1036 GKGYFADHAKHKC 1048



 Score = 38.1 bits (87), Expect = 0.007
 Identities = 24/84 (28%), Positives = 32/84 (38%), Gaps = 13/84 (15%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCF--SQDFCIRCKRQFYLYKGKCLPTCPP 124
           G+CL  C   ++    +    C+ C  +C  C   S   C  C     L  G+CL  CP 
Sbjct: 693 GECLAQCRAHFYL---ESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPD 749

Query: 125 G--------TLAHQNTRECQGECE 140
           G        T  H   R+C G  E
Sbjct: 750 GYFHQEGSCTECHPTCRQCHGPLE 773



 Score = 31.6 bits (70), Expect = 0.61
 Identities = 13/41 (31%), Positives = 20/41 (48%), Gaps = 8/41 (19%)

Query: 37   GCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGY 77
            GC+ CS  + C  C    FL        + G C+++C PG+
Sbjct: 1054 GCLQCSHRDRCHLCDHGFFL--------KSGLCVYNCVPGF 1086



 Score = 28.5 bits (62), Expect = 5.2
 Identities = 22/83 (26%), Positives = 34/83 (40%), Gaps = 11/83 (13%)

Query: 61  EGIRQYGKCLHDCPPGYFGIRGQEVNRC----KKCGATCESCFSQDFCIRCKRQFYLYKG 116
           E I + G C+++    +      EV R     K     C+ C  +   + C      Y+ 
Sbjct: 341 ECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTC------YEP 394

Query: 117 KCLPTCPPGTLAHQNTRECQGEC 139
            C P CP GTLA +   +C  +C
Sbjct: 395 SC-PPCPVGTLALEVKGQCCPDC 416


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 19/93 (20%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQ--DFCIRCKRQFYLYK--GKCLPTCPP 124
           C+  CPPG++     +  RC+KC   CESCF    D C+ CK  ++L +    C+  CP 
Sbjct: 670 CVSSCPPGHYHA---DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPD 726

Query: 125 GTLAHQNTRECQGECELGPWGGWSPCTHNGKTC 157
           G+        C+             C+ N KTC
Sbjct: 727 GSYQDTKKNLCR------------KCSENCKTC 747



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 36/167 (21%), Positives = 66/167 (39%), Gaps = 28/167 (16%)

Query: 38  CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCES 97
           C  C+E + C+ C+  L L        Q  +C   C  G +   GQ+   C +  ATC  
Sbjct: 744 CKTCTEFHNCTECRDGLSL--------QGSRCSVSCEDGRY-FNGQDCQPCHRFCATCAG 794

Query: 98  CFSQDFCIRCKRQFYLYKGKCLPTCP-------PGTLAHQNTRECQGECELGPWGGWSPC 150
               D CI C   +++  G+C+ +C             +++ ++C   C      G+  C
Sbjct: 795 A-GADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNC 853

Query: 151 THNGKTCGSAWGLE-------SRVREAGRAGHEEAATCQVLSESRKC 190
           T    +C S + L+       +  ++A      E   C ++ ++  C
Sbjct: 854 T----SCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLC 896



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 32/127 (25%), Positives = 49/127 (38%), Gaps = 23/127 (18%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           NC  C   S  + C +C+   FL        +   C+  CP G +  +  + N C+KC  
Sbjct: 692 NCESCF-GSHGDQCMSCKYGYFLN------EETNSCVTHCPDGSY--QDTKKNLCRKCSE 742

Query: 94  TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHN 153
            C++C     C  C+    L   +C  +C  G   + N ++CQ            PC   
Sbjct: 743 NCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG--RYFNGQDCQ------------PCHRF 788

Query: 154 GKTCGSA 160
             TC  A
Sbjct: 789 CATCAGA 795


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 53/197 (26%), Positives = 65/197 (32%), Gaps = 51/197 (25%)

Query: 32  GGNC---TGCIICSE-------ENGCST------CQQRLFLFIRREGIRQYGKCLHD--- 72
           GG C   TG   C         E+GC        C+++     R    R YG CL D   
Sbjct: 573 GGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGL 632

Query: 73  --------CPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
                   CPP  FG    E  +C +     +SC  +D    CK  F             
Sbjct: 633 YGRFCHLTCPPWAFGPGCSEECQCVQ--PHTQSCDKRDGSCSCKAGF------------- 677

Query: 125 GTLAHQNTRECQGECELGPWGG--WSPCT-HNGKTCGSAWGLESRVREAGRAGHEEAATC 181
                     CQ ECELG +G   W  CT   G  C S  G   +   AG  G +    C
Sbjct: 678 ------RGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQEC 731

Query: 182 QVLSESRKCPIQRPCPG 198
            V +    C     C G
Sbjct: 732 PVGTFGVNCSSSCSCGG 748



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 25/90 (27%), Positives = 35/90 (38%), Gaps = 19/90 (21%)

Query: 69   CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
            C H CP G+FG+  +    C   GA C++      C   +R       +C  TCP  T  
Sbjct: 943  CEHACPAGFFGLDCRSACNC-TAGAACDAVNGSCLCPAGRR-----GPRCAETCPAHTYG 996

Query: 129  HQNTREC-----------QGECELGPWGGW 147
            H  ++ C            G+C   P  GW
Sbjct: 997  HNCSQACACFNGASCDPVHGQCHCAP--GW 1024



 Score = 35.4 bits (80), Expect = 0.042
 Identities = 29/98 (29%), Positives = 40/98 (40%), Gaps = 13/98 (13%)

Query: 66   YGK-CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPP 124
            YG+ C H CPPG+ G   Q +  C+  GA C+    +  C       +  +G     C P
Sbjct: 1370 YGQACEHPCPPGFHGAGCQGLCWCQH-GAPCDPISGRCLCPAGFHGHFCERG-----CEP 1423

Query: 125  GTL---AHQNTRECQGECELGPWGGWSPCT--HNGKTC 157
            G+     HQ   +C G     P  G   C    +G TC
Sbjct: 1424 GSFGEGCHQRC-DCDGGAPCDPVTGLCLCPPGRSGATC 1460



 Score = 34.3 bits (77), Expect = 0.095
 Identities = 34/128 (26%), Positives = 48/128 (37%), Gaps = 31/128 (24%)

Query: 35  CTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD------CPPGYFGIRGQ-EVNR 87
           C G +   +E GC + +    L          G+C+        CPPG+ G R Q +V+ 
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFHG------GRCVPGSAQPCHCPPGFQGPRCQYDVDE 164

Query: 88  CKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQ--GECELGPWG 145
           C+     C+         RC        G  L  C PG   H ++R C     C LG  G
Sbjct: 165 CRTHNGGCQH--------RCVNT----PGSYLCECKPGFRLHTDSRTCLAINSCALGNGG 212

Query: 146 GWSPCTHN 153
               C H+
Sbjct: 213 ----CQHH 216



 Score = 33.5 bits (75), Expect = 0.16
 Identities = 33/137 (24%), Positives = 49/137 (35%), Gaps = 39/137 (28%)

Query: 41  CSEENGC-----STCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCK------ 89
           CSEE  C      +C +R      + G R   +C  +C  GYFG    +   C       
Sbjct: 650 CSEECQCVQPHTQSCDKRDGSCSCKAGFRGE-RCQAECELGYFGPGCWQACTCPVGVACD 708

Query: 90  ----KCGATCESCFSQDFC----------IRCKRQF-------YLYKGKCLPTCPPGTLA 128
               +CG  C + F  + C          + C           +   G+C   CPPG   
Sbjct: 709 SVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQC--RCPPG--- 763

Query: 129 HQNTRECQGECELGPWG 145
            +   +C+ +C  G WG
Sbjct: 764 -RTGEDCEADCPEGRWG 779



 Score = 32.7 bits (73), Expect = 0.28
 Identities = 37/137 (27%), Positives = 47/137 (34%), Gaps = 36/137 (26%)

Query: 32   GGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKC 91
            G NCT    C +   C                   G CL  CPPG  G+R +      + 
Sbjct: 1255 GPNCTHVCGCGQGAACDPVT---------------GTCL--CPPGRAGVRCERGCPQNRF 1297

Query: 92   GATCE---SCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGG-- 146
            G  CE   SC +   C       +   G C  +C  G       R C+  C  G +G   
Sbjct: 1298 GVGCEHTCSCRNGGLC-------HASNGSC--SCGLGWTG----RHCELACPPGRYGAAC 1344

Query: 147  WSPCT-HNGKTCGSAWG 162
               C+ HN  TC  A G
Sbjct: 1345 HLECSCHNNSTCEPATG 1361



 Score = 32.3 bits (72), Expect = 0.36
 Identities = 44/188 (23%), Positives = 57/188 (30%), Gaps = 40/188 (21%)

Query: 32   GGNC---TGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHD-----------CPPGY 77
            GG C   +G   C E      C++       R G R  G CL+            CP G+
Sbjct: 1051 GGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGW 1110

Query: 78   FGIRGQEVNRCKKCGATC-ESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQ 136
             G          KC + C    F +    RC             +CPPG   H  T  C+
Sbjct: 1111 TG---------DKCQSPCLRGWFGEACAQRC-------------SCPPGAACHHVTGACR 1148

Query: 137  GECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPC 196
              C  G  G          + G       +      A H    TC   +       Q+ C
Sbjct: 1149 --CPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRC 1206

Query: 197  -PGERSPG 203
             PG   PG
Sbjct: 1207 PPGRYGPG 1214



 Score = 32.0 bits (71), Expect = 0.47
 Identities = 32/123 (26%), Positives = 45/123 (36%), Gaps = 22/123 (17%)

Query: 68  KCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTL 127
           +C   CP G+FG   ++  +C+  GA C+       C    R  +     C   CP G  
Sbjct: 899 RCEQQCPQGHFGPGCEQRCQCQH-GAACDHVSGACTCPAGWRGTF-----CEHACPAGFF 952

Query: 128 AHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSES 187
                 +C+  C          CT  G  C +  G  S +  AGR G   A TC   +  
Sbjct: 953 G----LDCRSACN---------CT-AGAACDAVNG--SCLCPAGRRGPRCAETCPAHTYG 996

Query: 188 RKC 190
             C
Sbjct: 997 HNC 999



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 28/109 (25%), Positives = 38/109 (34%), Gaps = 31/109 (28%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCI------RCK-------------- 108
           C  DCP G +G+  QE+    +  A C+       C+      RC+              
Sbjct: 769 CEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQT 828

Query: 109 RQFYLYKGKCLP-----TCPPGTLAHQNTRECQGECELGPWGGWSPCTH 152
           R      G C P     +C PG         CQ  C+ G WG    C+H
Sbjct: 829 RCSCANDGHCHPATGHCSCAPGWTGF----SCQRACDTGHWG--PDCSH 871



 Score = 29.6 bits (65), Expect = 2.3
 Identities = 20/67 (29%), Positives = 25/67 (37%), Gaps = 6/67 (8%)

Query: 69   CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLA 128
            C   CPPG +G   +++  C   G    SC +     RC   F      C  TCP G   
Sbjct: 1202 CQQRCPPGRYGPGCEQLCGCLNGG----SCDAATGACRCPTGF--LGTDCNLTCPQGRFG 1255

Query: 129  HQNTREC 135
               T  C
Sbjct: 1256 PNCTHVC 1262



 Score = 27.7 bits (60), Expect = 8.9
 Identities = 35/145 (24%), Positives = 49/145 (33%), Gaps = 45/145 (31%)

Query: 69   CLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFC------IRCKRQFYLYKGKCLPT- 121
            CL  CP G +G   +    C+  G TC+       C      + C+++       CLP  
Sbjct: 1029 CLQACPAGLYGDNCRHSCLCQN-GGTCDPVSGHCACPEGWAGLACEKE-------CLPRD 1080

Query: 122  ----------CPPGTLAHQNTRECQGECELGPWGG---WSPCTHN--GKTCGSAWGLESR 166
                      C  G L   +T  C   C  G W G    SPC     G+ C         
Sbjct: 1081 VRAGCRHSGGCLNGGLCDPHTGRCL--CPAG-WTGDKCQSPCLRGWFGEAC--------- 1128

Query: 167  VREAGRAGHEEAATCQVLSESRKCP 191
               A R      A C  ++ + +CP
Sbjct: 1129 ---AQRCSCPPGAACHHVTGACRCP 1150


>gi|14790170 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 19/157 (12%)

Query: 57  FIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC-------ESCF-SQDFCIRCK 108
           F++R   R        CPP ++      + RC+ C   C        +C  + +   RC+
Sbjct: 57  FVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCR 116

Query: 109 RQFYLYKGKCL--PTCPPGT-LAHQNTRECQGECELGPWGGWSPCTHNGKTCG-----SA 160
             F+ + G CL   +CPPG  +    T     +C+  P G +S  + + + C      +A
Sbjct: 117 TGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTA 176

Query: 161 WGLESRVREAGRAGHEEAAT-CQVLSESRKCPIQRPC 196
            GL   V   G + H+   T C     S + P    C
Sbjct: 177 LGLALNV--PGSSSHDTLCTSCTGFPLSTRVPGAEEC 211


>gi|4507585 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 38/157 (24%), Positives = 62/157 (39%), Gaps = 19/157 (12%)

Query: 57  FIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATC-------ESCF-SQDFCIRCK 108
           F++R   R        CPP ++      + RC+ C   C        +C  + +   RC+
Sbjct: 57  FVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCR 116

Query: 109 RQFYLYKGKCL--PTCPPGT-LAHQNTRECQGECELGPWGGWSPCTHNGKTCG-----SA 160
             F+ + G CL   +CPPG  +    T     +C+  P G +S  + + + C      +A
Sbjct: 117 TGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTA 176

Query: 161 WGLESRVREAGRAGHEEAAT-CQVLSESRKCPIQRPC 196
            GL   V   G + H+   T C     S + P    C
Sbjct: 177 LGLALNV--PGSSSHDTLCTSCTGFPLSTRVPGAEEC 211


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score = 40.0 bits (92), Expect = 0.002
 Identities = 54/203 (26%), Positives = 67/203 (33%), Gaps = 39/203 (19%)

Query: 24  KKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQ 83
           K Q G G    C     C   +GC     R        G R    C   CP G +G+   
Sbjct: 526 KGQFGEGCASRCD----CDHSDGCDPVHGRCQCQAGWMGAR----CHLSCPEGLWGVNCS 577

Query: 84  EVNRCKKCGATCESCFSQDFCI------RCKR--QFYLYKGKCLPT-------CPPGT-- 126
               CK  G TC        C        C+R  Q   Y  +C+P        C P    
Sbjct: 578 NTCTCKN-GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGT 636

Query: 127 ---LAHQNTRECQGECELGPWGGWSPCT---HNGKTCGSAWGLESRVREAGRAGHEEAAT 180
              LA     +C   C  G WG     T   H+G TC    G  S +   G  GH     
Sbjct: 637 CYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDG--SCICPLGWTGHHCLEG 694

Query: 181 CQVLSESRKCPIQRPC---PGER 200
           C + +    C   +PC   PGE+
Sbjct: 695 CPLGTFGANC--SQPCQCGPGEK 715



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 50/201 (24%), Positives = 66/201 (32%), Gaps = 53/201 (26%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C     C  ++G  +C   L          Q   CL  C PGY+G   Q   RC+  GA
Sbjct: 149 SCGNNSSCDPKSGVCSCPSGL----------QPPNCLQPCTPGYYGPACQ--FRCQCHGA 196

Query: 94  TCESCFSQDFC----------IRCKR-----------------QFYLYKGKCLPTCPPGT 126
            C+      FC          + C +                  F   +G C  +CPPG 
Sbjct: 197 PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSC--SCPPGW 254

Query: 127 LAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWG--------LESRVRE---AGRAGH 175
           +    +  C  E   GP        HNG  C    G           R RE    GR G 
Sbjct: 255 MGTICSLPCP-EGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQ 313

Query: 176 EEAATCQVLSESRKCPIQRPC 196
           + A TC    ++R  P    C
Sbjct: 314 DCAETCDCAPDARCFPANGAC 334



 Score = 35.4 bits (80), Expect = 0.042
 Identities = 26/98 (26%), Positives = 36/98 (36%), Gaps = 27/98 (27%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCE-----SCFSQDFCIRCKRQFYLYKGKCLPTCP 123
           C   CPPG++G         + C  TC+     +C  QD    C   +  +   CL  CP
Sbjct: 648 CSQPCPPGHWG---------ENCAQTCQCHHGGTCHPQDGSCICPLGWTGH--HCLEGCP 696

Query: 124 PGTLAHQNTRECQ-----------GECELGPWGGWSPC 150
            GT     ++ CQ           G C   P    +PC
Sbjct: 697 LGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPC 734



 Score = 34.7 bits (78), Expect = 0.072
 Identities = 32/133 (24%), Positives = 43/133 (32%), Gaps = 31/133 (23%)

Query: 34  NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           +C   I CS  +G   C++            Q G C   CPPG +G           C A
Sbjct: 452 SCENAIACSPIDGECVCKEGW----------QRGNCSVPCPPGTWGF---------SCNA 492

Query: 94  TCES-----CFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWS 148
           +C+      C  Q     C   +  +   C   CP G    Q    C   C+     G  
Sbjct: 493 SCQCAHEAVCSPQTGACTCTPGW--HGAHCQLPCPKG----QFGEGCASRCDCDHSDGCD 546

Query: 149 PCTHNGKTCGSAW 161
           P  H    C + W
Sbjct: 547 P-VHGRCQCQAGW 558



 Score = 33.9 bits (76), Expect = 0.12
 Identities = 26/90 (28%), Positives = 31/90 (34%), Gaps = 18/90 (20%)

Query: 69  CLHDCPPGYFGIRGQEVNRCKKCGATCE-----SCFSQDFCIRCKRQFYLYKGKCLPTCP 123
           C   CPP  +G+          C A C      +C   D    CK  +   +G C   CP
Sbjct: 434 CASLCPPDTYGVN---------CSARCSCENAIACSPIDGECVCKEGWQ--RGNCSVPCP 482

Query: 124 PGTLAHQNTRECQ--GECELGPWGGWSPCT 151
           PGT        CQ   E    P  G   CT
Sbjct: 483 PGTWGFSCNASCQCAHEAVCSPQTGACTCT 512


>gi|111125011 WNT inhibitory factor 1 precursor [Homo sapiens]
          Length = 379

 Score = 39.7 bits (91), Expect = 0.002
 Identities = 29/94 (30%), Positives = 39/94 (41%), Gaps = 29/94 (30%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGT 126
           G C+  CPPG++G+   + N    C  T   CF+   C         Y GKC+  CPPG 
Sbjct: 228 GFCI--CPPGFYGVNCDKAN----CSTT---CFNGGTC--------FYPGKCI--CPPGL 268

Query: 127 LAHQNTRECQGECELGPWGGWSPCTHNGKTCGSA 160
              Q        CE+       PC + GK  G +
Sbjct: 269 EGEQ--------CEISKCP--QPCRNGGKCIGKS 292


>gi|31657140 insulin receptor-related receptor precursor [Homo
           sapiens]
          Length = 1297

 Score = 39.3 bits (90), Expect = 0.003
 Identities = 31/113 (27%), Positives = 44/113 (38%), Gaps = 24/113 (21%)

Query: 37  GCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCE 96
           GC    +   C  C+   F           G CL  CPPG +     E  RC     T E
Sbjct: 236 GCSQPEDPRACVACRHLYF----------QGACLWACPPGTYQY---ESWRC----VTAE 278

Query: 97  SCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNT---RECQG----ECELG 142
            C S          F +++G CL  CP G   + ++    +C+G    EC++G
Sbjct: 279 RCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKVG 331



 Score = 31.6 bits (70), Expect = 0.61
 Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 2/44 (4%)

Query: 90  KCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTR 133
           +C   C        C+ C+  ++  +G CL  CPPGT  +++ R
Sbjct: 232 ECLGGCSQPEDPRACVACRHLYF--QGACLWACPPGTYQYESWR 273


>gi|4505737 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 32/110 (29%), Positives = 42/110 (38%), Gaps = 10/110 (9%)

Query: 91  CGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGEC--ELGPWGGWS 148
           C  TC    S+   +R +R    + G+C     PGTL  Q       +C  E+G W GW 
Sbjct: 89  CSVTC----SEGSQLRYRRCVG-WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWG 143

Query: 149 PCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQ-VLSESRKCPIQRPCP 197
           P      TC    G  +R R       +    C     ES  C  Q+ CP
Sbjct: 144 PWEPCSVTCSK--GTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCP 191



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 29/102 (28%), Positives = 38/102 (37%), Gaps = 16/102 (15%)

Query: 123 PPGT----LAHQNTRECQG--ECEL-GPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGH 175
           PPG     LA++  R C G   C + G WG W P +    TCG    +E R        H
Sbjct: 233 PPGKPCPGLAYEQ-RRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH 291

Query: 176 EEAATCQVLSESRKCPIQRPCP--------GERSPGQKKGRK 209
                    + +  C    PCP        GE SP  ++  K
Sbjct: 292 GGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMK 333


>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
          Length = 1609

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 28/98 (28%), Positives = 41/98 (41%), Gaps = 11/98 (11%)

Query: 29  TGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRC 88
           TG GG+CT C   ++   C  C++  F    R G  +     H  P G    +     RC
Sbjct: 361 TGHGGHCTNCQDNTDGAHCERCRENFF----RLGNNEACSSCHCSPVGSLSTQCDSYGRC 416

Query: 89  KKCGATCESCFSQDFCIRCKRQFY-LYKGKCLP-TCPP 124
                +C+     D C RC+  F+ L +  C P +C P
Sbjct: 417 -----SCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDP 449


>gi|119395738 insulin receptor isoform Short precursor [Homo
           sapiens]
          Length = 1370

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 25/83 (30%), Positives = 35/83 (42%), Gaps = 19/83 (22%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKR-------QFYLYKGKCL 119
           G+C+  CPP Y+  +     RC          F QD   +CK        Q+ ++  KC+
Sbjct: 262 GRCVETCPPPYYHFQDW---RCVNFS------FCQDLHHKCKNSRRQGCHQYVIHNNKCI 312

Query: 120 PTCPPG-TLAHQN--TRECQGEC 139
           P CP G T+   N     C G C
Sbjct: 313 PECPSGYTMNSSNLLCTPCLGPC 335


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 25/83 (30%), Positives = 35/83 (42%), Gaps = 19/83 (22%)

Query: 67  GKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKR-------QFYLYKGKCL 119
           G+C+  CPP Y+  +     RC          F QD   +CK        Q+ ++  KC+
Sbjct: 262 GRCVETCPPPYYHFQDW---RCVNFS------FCQDLHHKCKNSRRQGCHQYVIHNNKCI 312

Query: 120 PTCPPG-TLAHQN--TRECQGEC 139
           P CP G T+   N     C G C
Sbjct: 313 PECPSGYTMNSSNLLCTPCLGPC 335


>gi|223671861 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score = 38.5 bits (88), Expect = 0.005
 Identities = 32/110 (29%), Positives = 42/110 (38%), Gaps = 10/110 (9%)

Query: 91  CGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGEC--ELGPWGGWS 148
           C  TC    S+   +R +R    + G+C     PGTL  Q       +C  E+G W GW 
Sbjct: 89  CSVTC----SEGSQLRYRRCVG-WNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWG 143

Query: 149 PCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQ-VLSESRKCPIQRPCP 197
           P      TC    G  +R R       +    C     ES  C  Q+ CP
Sbjct: 144 PWEPCSVTCSK--GTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCP 191



 Score = 30.4 bits (67), Expect = 1.4
 Identities = 29/102 (28%), Positives = 38/102 (37%), Gaps = 16/102 (15%)

Query: 123 PPGT----LAHQNTRECQG--ECEL-GPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGH 175
           PPG     LA++  R C G   C + G WG W P +    TCG    +E R        H
Sbjct: 233 PPGKPCPGLAYEQ-RRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQH 291

Query: 176 EEAATCQVLSESRKCPIQRPCP--------GERSPGQKKGRK 209
                    + +  C    PCP        GE SP  ++  K
Sbjct: 292 GGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMK 333


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
           sapiens]
          Length = 1367

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 4/68 (5%)

Query: 68  KCLHDCPPGYFGIRGQEVNRC--KKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPG 125
           +C   CP         E N C   +C  +C +  +   C+ C+   Y Y G C+P CPP 
Sbjct: 210 RCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRH--YYYAGVCVPACPPN 267

Query: 126 TLAHQNTR 133
           T   +  R
Sbjct: 268 TYRFEGWR 275



 Score = 32.7 bits (73), Expect = 0.28
 Identities = 24/117 (20%), Positives = 38/117 (32%), Gaps = 35/117 (29%)

Query: 35  CTG-CIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA 93
           C G C     +  C  C+   +           G C+  CPP  +   G           
Sbjct: 235 CLGSCSAPDNDTACVACRHYYYA----------GVCVPACPPNTYRFEGWR--------- 275

Query: 94  TCESCFSQDFCIRC-------KRQFYLYKGKCLPTCPPGTLAHQNTR----ECQGEC 139
               C  +DFC             F ++ G+C+  CP G + + +       C+G C
Sbjct: 276 ----CVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPC 328


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 38.1 bits (87), Expect = 0.007
 Identities = 31/97 (31%), Positives = 39/97 (40%), Gaps = 18/97 (18%)

Query: 101  QDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSA 160
            QD C  C  Q         P CPP T            C    W  WSPC+H   +CG  
Sbjct: 4134 QDACNNCSCQAGQLSCTAQP-CPPPT-----------HCAWSHWSAWSPCSH---SCGPR 4178

Query: 161  WGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPCP 197
             G +SR R +  +G       +  S+S+ CP Q  CP
Sbjct: 4179 -GQQSRFR-SSTSGSWAPECREEQSQSQPCP-QPSCP 4212



 Score = 35.0 bits (79), Expect = 0.055
 Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 9/86 (10%)

Query: 90   KCGATC--ESCFSQDFCIRCKRQFYLYKGKC-LPTCPP----GTLAHQNTRECQGECELG 142
            +C A+C    C    FC R             LP  P     G  A +     QG    G
Sbjct: 3194 QCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAG 3253

Query: 143  PWGGWSPCTHNGKTCGSAWGLESRVR 168
             WG W P +H  ++CG   GL SR R
Sbjct: 3254 GWGPWGPWSHCSRSCGG--GLRSRTR 3277



 Score = 34.3 bits (77), Expect = 0.095
 Identities = 26/70 (37%), Positives = 31/70 (44%), Gaps = 12/70 (17%)

Query: 138  ECE-LGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQV--LSESRKCPIQR 194
            EC  LGPW  WS C+     CG       R  E G       A CQ     + ++C +Q 
Sbjct: 4762 ECPVLGPWSAWSSCS---APCGGGTMERHRTCEGGPG----VAPCQAQDTEQRQECNLQ- 4813

Query: 195  PCPGERSPGQ 204
            PCP E  PGQ
Sbjct: 4814 PCP-ECPPGQ 4822



 Score = 33.1 bits (74), Expect = 0.21
 Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 29/91 (31%)

Query: 135  CQGECELGPWGGWSPC------THNGKTCGSAWGLESRVREAGR---AGHEEAATCQVLS 185
            C  +   GPWG WSPC      +H  + C           E GR     H ++  CQ   
Sbjct: 3469 CPVDGAWGPWGPWSPCDMCLGQSHRSRACS-----RPPTPEGGRPCPGNHTQSRPCQ--E 3521

Query: 186  ESRKC----------PIQRPCP---GERSPG 203
             S +C          P  +PCP    + SPG
Sbjct: 3522 NSTQCTDCGGGQSLHPCGQPCPRSCQDLSPG 3552



 Score = 32.7 bits (73), Expect = 0.28
 Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 5/81 (6%)

Query: 122  CPPGTLAHQNTRECQ-GECEL-GPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAA 179
            CP    A+Q  R C    C + G W  WSP +   ++CG    L SR   +  + +  A 
Sbjct: 3983 CPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAP 4042

Query: 180  TCQVLSESRKC---PIQRPCP 197
                  ++R C   P +  CP
Sbjct: 4043 CAGERHQARLCNPMPCEAGCP 4063



 Score = 32.3 bits (72), Expect = 0.36
 Identities = 26/81 (32%), Positives = 30/81 (37%), Gaps = 14/81 (17%)

Query: 119  LPTCP-PGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRV-REAGRAGHE 176
            LP CP PG  A        G C    W  W PC+   ++CG       R  R  G  GH 
Sbjct: 3934 LPVCPGPGCGA--------GNCSWTSWAPWEPCS---RSCGVGQQRRLRAYRPPGPGGHW 3982

Query: 177  EAATCQVLSESRKCPIQRPCP 197
                     E R C + R CP
Sbjct: 3983 CPNILTAYQERRFCNL-RACP 4002



 Score = 32.0 bits (71), Expect = 0.47
 Identities = 29/90 (32%), Positives = 36/90 (40%), Gaps = 12/90 (13%)

Query: 121  TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESR--VREAGRAGHEEA 178
            TC  G L  Q   +C        WG W  C+    +CG    L SR   R        ++
Sbjct: 3628 TCVAGILQCQEVPDCPDPGVWSSWGPWEDCS---VSCGGGEQLRSRRCARPPCPGPARQS 3684

Query: 179  ATC--QVLSESRKCP---IQRPC-PGERSP 202
             TC  QV  E+  CP   + R C PGE  P
Sbjct: 3685 RTCSTQVCREA-GCPAGRLYRECQPGEGCP 3713



 Score = 31.2 bits (69), Expect = 0.80
 Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)

Query: 121  TCPPGT-LAHQNTRECQGEC----ELGP---------WGGWSPCTHNGKTCGSAWGLESR 166
            TCP GT +  Q   + Q +C    ++GP         WG WSP     +TCG  WG + R
Sbjct: 1660 TCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCG-PWG-QGR 1717

Query: 167  VREAGRAGHEEAATCQVLSESRKCPIQRPCP 197
             R     G      C       +      CP
Sbjct: 1718 SRRCSPLGLLVLQNCPGPEHQSQACFTAACP 1748



 Score = 31.2 bits (69), Expect = 0.80
 Identities = 57/206 (27%), Positives = 70/206 (33%), Gaps = 71/206 (34%)

Query: 30   GLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCL--HDCPPGYFGIRGQ---- 83
            G G  CTG   C+   GC TC   LFL            CL    CP     + GQ    
Sbjct: 2913 GPGIECTG--FCAP--GC-TCPPGLFL--------HNASCLPRSQCP---CQLHGQLYAS 2956

Query: 84   ----EVNRCKKCGATCES----CFSQDFCIRCKRQFYLYKGKCLPTCPPGTL-------- 127
                 ++ C  C  TC S    C S+   + C    +     C  +C  G          
Sbjct: 2957 GAMARLDSCNNC--TCVSGKMACTSERCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTA 3014

Query: 128  --AHQNTRECQGE------CELGP-------WGGWSPCTHNGKTCGSAWGLESRVREAGR 172
              A     ECQG       C L P       WG WSPC+     CG   G  +R R + R
Sbjct: 3015 PPAAFGGAECQGPTMEAEFCSLRPCPGPGGEWGPWSPCS---VPCGG--GYRNRTRGSSR 3069

Query: 173  AGHEEAATCQVLSESRKCPIQRPCPG 198
            +          L E   C +Q PC G
Sbjct: 3070 S----------LMEFSTCGLQ-PCAG 3084



 Score = 29.6 bits (65), Expect = 2.3
 Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 7/47 (14%)

Query: 120  PTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESR 166
            P   P T   Q  + C G  E   WG W PC+   ++CG   GL SR
Sbjct: 4291 PCLGPDTQTRQ--QPCPGLLEACSWGPWGPCS---RSCGP--GLASR 4330



 Score = 29.6 bits (65), Expect = 2.3
 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 1/29 (3%)

Query: 122  CPPGTLAHQNTRECQGECELGPWGGWSPC 150
            C  G L H  ++ CQG   L  W  WSPC
Sbjct: 4507 CRRGEL-HCTSQGCQGLLPLSEWSEWSPC 4534



 Score = 28.9 bits (63), Expect = 4.0
 Identities = 17/57 (29%), Positives = 19/57 (33%), Gaps = 3/57 (5%)

Query: 135  CQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCP 191
            C   C+   WG WSPC      C   + L  R  EA   G       Q       CP
Sbjct: 4612 CPDSCQWSLWGPWSPCQ---VPCSGGFRLRWREAEALCGGGCREPWAQESCNGGPCP 4665



 Score = 28.5 bits (62), Expect = 5.2
 Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 8/53 (15%)

Query: 116  GKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVR 168
            G C  +C  G L+       + +   GPW  W PC+   ++CG   GL +R R
Sbjct: 3791 GNC--SCAHGKLSCSLDDCFEADGGFGPWSPWGPCS---RSCG---GLGTRTR 3835



 Score = 28.1 bits (61), Expect = 6.8
 Identities = 32/123 (26%), Positives = 44/123 (35%), Gaps = 44/123 (35%)

Query: 73   CPPGYFGIRGQEVNRCKKCGATC-ESCFSQDFCIRCKRQFYLYKGKCLPT--CP------ 123
            CPP     +       + C   C E C       RC     L+  +CLP   CP      
Sbjct: 2635 CPPSCLDPKAN-----RSCSGHCVEGC-------RCPPGLLLHDTRCLPLSECPCLVGEE 2682

Query: 124  ---PG-TLAHQNTREC---QGE-----------CELGPWGGWSPCTHNGKTCGSAWGLES 165
               PG +    N  +C   +GE           C    W  W+PC    ++CGS  G+ +
Sbjct: 2683 LKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPC---DRSCGS--GVRA 2737

Query: 166  RVR 168
            R R
Sbjct: 2738 RFR 2740



 Score = 27.7 bits (60), Expect = 8.9
 Identities = 14/41 (34%), Positives = 22/41 (53%), Gaps = 4/41 (9%)

Query: 121  TCPPGTLAHQNTREC-QGECELGPWGGWSPCTHNGKTCGSA 160
            +C  G +A+ ++  C +GE    PW  WS C+    +CG A
Sbjct: 3165 SCVSGLIANCSSWPCAEGEPTWSPWTPWSQCS---ASCGPA 3202


>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
           [Homo sapiens]
          Length = 250

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 52/196 (26%), Positives = 69/196 (35%), Gaps = 54/196 (27%)

Query: 26  QVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEV 85
           Q G G GG    C++  +++ C     RL+    REG      C   C            
Sbjct: 79  QPGAGPGGRGALCLLAEDDSSCEV-NGRLY----REGETFQPHCSIRC------------ 121

Query: 86  NRCKKCGATCESCFSQDF------CIRCKRQFYLYKGKCLP--TCPPGTLAHQNTRECQG 137
            RC+  G TC    S+D       C   +R   L  GKC P   C  G          QG
Sbjct: 122 -RCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVL--GKCCPEWVCGQGGGLGTQPLPAQG 178

Query: 138 ECELG------------PWG-GWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVL 184
               G             W   W PC+    TCG   G+ +RV    R        C++ 
Sbjct: 179 PQFSGLVSSLPPGVPCPEWSTAWGPCS---TTCG--LGMATRVSNQNR-------FCRLE 226

Query: 185 SESRKCPIQRPCPGER 200
           ++ R C + RPCP  R
Sbjct: 227 TQRRLC-LSRPCPPSR 241


>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
          Length = 1585

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 17/89 (19%)

Query: 116 GKCLPTCPPGTLAHQNTRECQG-EC-----ELGPWGGWSPCTHNGKTCGSAWGLESRVRE 169
           G    TC   T A  +TREC   EC     + GPW  WS C+   KTC + W    R+ +
Sbjct: 450 GPAWATC---TGALTDTRECSNLECPATDSKWGPWNAWSLCS---KTCDTGWQRRFRMCQ 503

Query: 170 A-GRAGHEEAATCQVLSESRKCPIQRPCP 197
           A G  G+     C+   E  K   ++ CP
Sbjct: 504 ATGTQGY----PCEGTGEEVKPCSEKRCP 528



 Score = 31.2 bits (69), Expect = 0.80
 Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 6/67 (8%)

Query: 135 CQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQR 194
           C  E +   WG W PC+    +C +  G + R R+   AG   A     L+++R+C    
Sbjct: 416 CPVEGQWLEWGPWGPCS---TSCAN--GTQQRSRKCSVAGPAWATCTGALTDTRECS-NL 469

Query: 195 PCPGERS 201
            CP   S
Sbjct: 470 ECPATDS 476


>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
           sapiens]
          Length = 1657

 Score = 37.4 bits (85), Expect = 0.011
 Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 22/108 (20%)

Query: 135 CQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQR 194
           CQ +C +  +  WS C+   KTCGS  GL+ R R          + C  L+E + C    
Sbjct: 191 CQQDCIVSEFSAWSECS---KTCGS--GLQHRTRHVVAPPQFGGSGCPNLTEFQVCQ-SS 244

Query: 195 PCPGER--------------SPGQKKGRKDRR--PRKDRKLDRRLDVR 226
           PC  E                P  ++ R+ RR    K+R+ DR   V+
Sbjct: 245 PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVK 292



 Score = 36.2 bits (82), Expect = 0.025
 Identities = 18/62 (29%), Positives = 24/62 (38%), Gaps = 8/62 (12%)

Query: 135 CQGECELGPWGGWSPCTHNGKTCGSAWGLES------RVREAGRAGHEEAATCQVLSESR 188
           C  ECE+ PW  W PCT+  + C    G +       R+      G      C  L E+ 
Sbjct: 509 CPTECEVSPWSAWGPCTY--ENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAI 566

Query: 189 KC 190
            C
Sbjct: 567 PC 568



 Score = 35.8 bits (81), Expect = 0.033
 Identities = 22/65 (33%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 135 CQGECELGPWGGWSPCTH--NGKTC-GSAWGLESRVREAGRAGHEEAATCQVLSESRKCP 191
           C  +C L  W  WS C+H  +GKT  G      S +  AG  G         L E R C 
Sbjct: 631 CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN 690

Query: 192 IQRPC 196
            + PC
Sbjct: 691 -EHPC 694



 Score = 35.8 bits (81), Expect = 0.033
 Identities = 20/64 (31%), Positives = 31/64 (48%), Gaps = 6/64 (9%)

Query: 134  ECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATC-QVLSESRKCPI 192
            EC   C+L  W  WS C+   +TCG   G   R R   +    +   C  ++ +S+ CP+
Sbjct: 1282 ECPVNCQLSDWSPWSECS---QTCGLT-GKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPV 1337

Query: 193  QRPC 196
             +PC
Sbjct: 1338 -KPC 1340



 Score = 31.6 bits (70), Expect = 0.61
 Identities = 12/32 (37%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 135  CQGECELGPWGGWSPCTHNGKTCGSAWGLESR 166
            C  +C+L  W  WS C+   K+CGS   + S+
Sbjct: 1032 CPSDCKLSEWSNWSRCS---KSCGSGVKVRSK 1060



 Score = 29.3 bits (64), Expect = 3.0
 Identities = 14/53 (26%), Positives = 18/53 (33%)

Query: 138 ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKC 190
           EC++  W  WSPC+       S  G   R R   +        C    E   C
Sbjct: 360 ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPC 412



 Score = 28.5 bits (62), Expect = 5.2
 Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 4/62 (6%)

Query: 135  CQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQR 194
            C  +C +  WG W+ C      C  +     R  +  R   +E  +C    E   C + +
Sbjct: 1162 CPEDCVISEWGPWTQCV---LPCNQS-SFRQRSADPIRQPADEGRSCPNAVEKEPCNLNK 1217

Query: 195  PC 196
             C
Sbjct: 1218 NC 1219


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.485 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,605,440
Number of Sequences: 37866
Number of extensions: 618802
Number of successful extensions: 2470
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 2075
Number of HSP's gapped (non-prelim): 408
length of query: 234
length of database: 18,247,518
effective HSP length: 99
effective length of query: 135
effective length of database: 14,498,784
effective search space: 1957335840
effective search space used: 1957335840
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.