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Search of human proteins with 83715966
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 1337 0.0
gi|39930351 dynamin binding protein [Homo sapiens] 256 6e-68
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 103 7e-22
gi|8923173 hypothetical protein LOC54848 [Homo sapiens] 91 5e-18
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 88 3e-17
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 87 5e-17
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 87 5e-17
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 84 4e-16
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 82 1e-15
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 82 1e-15
gi|71274148 pleckstrin homology domain containing, family G (wit... 77 5e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 77 5e-14
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 77 5e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 72 2e-12
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 72 2e-12
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 72 2e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 71 4e-12
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 70 5e-12
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 70 8e-12
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 69 1e-11
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 68 2e-11
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 68 2e-11
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 68 3e-11
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 67 5e-11
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 67 5e-11
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 67 5e-11
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 66 1e-10
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 66 1e-10
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 66 1e-10
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 65 2e-10
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 1337 bits (3459), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRL 60
MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRL
Sbjct: 1 MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRL 60
Query: 61 QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKV 120
QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKV
Sbjct: 61 QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKV 120
Query: 121 YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ 180
YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ
Sbjct: 121 YCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQ 180
Query: 181 KILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINT 240
KILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINT
Sbjct: 181 KILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINT 240
Query: 241 HTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAF 300
HTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAF
Sbjct: 241 HTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAF 300
Query: 301 LYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNL 360
LYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNL
Sbjct: 301 LYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNL 360
Query: 361 IKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQI 420
IKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQI
Sbjct: 361 IKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQI 420
Query: 421 MCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEK 480
MCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEK
Sbjct: 421 MCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEK 480
Query: 481 VQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKD 540
VQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKD
Sbjct: 481 VQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKD 540
Query: 541 TKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPS 600
TKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPS
Sbjct: 541 TKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPS 600
Query: 601 IPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL 660
IPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL
Sbjct: 601 IPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL 660
Query: 661 ARARSPVLWGWSLPS 675
ARARSPVLWGWSLPS
Sbjct: 661 ARARSPVLWGWSLPS 675
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 256 bits (653), Expect = 6e-68
Identities = 176/592 (29%), Positives = 296/592 (50%), Gaps = 49/592 (8%)
Query: 13 SGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ--LPQGDLDV 70
SGS E E R L + + EL+ TE Y+ L++C I +QQ +P D +
Sbjct: 769 SGSVSAEN--PEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEG 826
Query: 71 LFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALL 130
LF N+ +IKV+ + L L+ + + VG +FL ++ELE YK+YC ++D+A+
Sbjct: 827 LFGNMQMVIKVSKQLLAALEISDA--------VGPVFLGHRDELEGTYKIYCQNHDEAIA 878
Query: 131 LVDTYRKEPELQRHIQGIVEAVVPQAGSSG------LSFLLVIPLQRITRYPLLLQKILE 184
L++ Y K+ ++Q+H+Q + + G L L+ P+QR+ RYPLLL ++L
Sbjct: 879 LLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLN 938
Query: 185 NTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINTHTLS 244
+T L AV A++++N NINEYK RK++ KY K ++ +L E+++++N H++
Sbjct: 939 STPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSII 998
Query: 245 KKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAFLYFR 304
KK+ R+S LK G P+ +D+ F++ E+ F+ + +++ YL +++ +
Sbjct: 999 KKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVK 1058
Query: 305 ------PHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQ 358
+ ++ Q+ + R + + F FK+R E LV PL L GP
Sbjct: 1059 VVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPH 1118
Query: 359 NLIKKRLDKLLDFERVEEKLLEVGSVTYQEE--AARHTYQALNSLLVAELPQFNQLVMQW 416
L++KR DKLLDF E+ ++ EE +AR+ Y+ALN+ L+ ELP+F+Q
Sbjct: 1119 KLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGL 1178
Query: 417 LGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQE 476
+ + D Q L++ + ++ L E + + R QL+ F
Sbjct: 1179 FTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAG-REGNLIAIFHEEHSRVLQQLQVF-- 1235
Query: 477 TFEKVQPPPTTQPL----------------LPG----SERQVQALLSRYGPGKLYQVTSN 516
TF P T +P LP SE +LL+RY P KL+Q N
Sbjct: 1236 TFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERN 1295
Query: 517 ISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQLYH 568
+ LD++L G +V +++ KD G+ RWL+D G +G+V + L+ Y+
Sbjct: 1296 FNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYN 1347
Score = 61.2 bits (147), Expect = 3e-09
Identities = 30/59 (50%), Positives = 41/59 (69%), Gaps = 1/59 (1%)
Query: 605 NQV-IAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLAR 662
NQV A Y F AR+ +E+S+ A Q + ILE +D GN EW L EVNG++GYVPS ++ +
Sbjct: 1515 NQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573
Score = 36.6 bits (83), Expect = 0.078
Identities = 15/42 (35%), Positives = 26/42 (61%)
Query: 524 DLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQ 565
+L++ Q + IL+ KD GN+ WL + G +GYVP+ ++
Sbjct: 1531 ELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIR 1572
Score = 33.5 bits (75), Expect = 0.66
Identities = 35/139 (25%), Positives = 56/139 (40%), Gaps = 25/139 (17%)
Query: 524 DLTLPRGQIVAILQNKDTKGNSGRWLVDTG--GHRGYVPAGKLQLYHVVPSAEELRRQAG 581
+L L RG +V IL T G WL G RG+ P+ ++ + + + Q+
Sbjct: 84 NLPLHRGDLV-ILDGIPTAG----WLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSA 138
Query: 582 LNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNP 641
L + P +M Q A A+ E+ + G +TI+ + P
Sbjct: 139 LFQIPEY--------------SMGQARALMGLSAQLDEELDFREGDVITIIGVPE----P 180
Query: 642 EWSLVEVNGQRGYVPSGFL 660
W E+ G+RG P GF+
Sbjct: 181 GWFEGELEGRRGIFPEGFV 199
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 103 bits (256), Expect = 7e-22
Identities = 86/278 (30%), Positives = 139/278 (50%), Gaps = 16/278 (5%)
Query: 5 GADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ-- 62
GA PSS G P R SE R L + + E++ TE Y+ L+ S R++Q
Sbjct: 26 GAAAPSSGPG-PCAAARESE-RQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNV 83
Query: 63 -------LPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELE 115
L + ++ VLFSNI+DI++V+ FL L+ E + +GN+FL+F+++
Sbjct: 84 ADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKF- 142
Query: 116 QVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRY 175
VY+ YC+++++AL L+ K P ++ + + + L L+ P+QRI +Y
Sbjct: 143 CVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKY 202
Query: 176 PLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLR-ER 234
PLLL+++ + T +P +Q A+ A++ V +NINE K + E K +EQL E
Sbjct: 203 PLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME---KLEALEQLQSHIEG 259
Query: 235 LARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDL 272
N + + LLK AG I FD+L
Sbjct: 260 WEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNL 297
>gi|8923173 hypothetical protein LOC54848 [Homo sapiens]
Length = 219
Score = 90.5 bits (223), Expect = 5e-18
Identities = 42/129 (32%), Positives = 80/129 (62%), Gaps = 2/129 (1%)
Query: 26 RSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQLPQGDLDV--LFSNIDDIIKVNS 83
R + + ++ELI TE YL+ L+LC ++ L+ LDV LFSNI+ + ++++
Sbjct: 90 RMMAKREKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISA 149
Query: 84 RFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQR 143
+ L L+E + E +Q++G +FL+ + LE +YK+YC +D+A ++++Y KE EL+
Sbjct: 150 KLLSLLEEATTDVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKE 209
Query: 144 HIQGIVEAV 152
H+ ++++
Sbjct: 210 HLSHCIQSL 218
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 87.8 bits (216), Expect = 3e-17
Identities = 63/228 (27%), Positives = 111/228 (48%), Gaps = 13/228 (5%)
Query: 8 EPSSRSGSPDREGRASEDRSLLHQRL------AVRELIDTEVSYL-HMLQLCASDIRS-- 58
E SS + S +++ AS+ R + +RE++DTE Y+ H+ +C IR
Sbjct: 212 ENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCR 271
Query: 59 -RLQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQV 117
L +F NI+DI K +FL DL++ +KEE + +G+ FL+ QE +
Sbjct: 272 KHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGF-AI 330
Query: 118 YKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPL 177
Y YC ++ A L + K+ + + + ++ Q + L+ P+Q+I +YPL
Sbjct: 331 YSEYCNNHPGACLELANLMKQGKYRHFFEAC--RLLQQMIDIAIDGFLLTPVQKICKYPL 388
Query: 178 LLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTK 225
L ++L+ T + Y ++ A A+++V INE K + E K +
Sbjct: 389 QLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIAR 436
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 87.0 bits (214), Expect = 5e-17
Identities = 65/219 (29%), Positives = 106/219 (48%), Gaps = 11/219 (5%)
Query: 10 SSRSGSPDREGRASEDRSLLHQRLAV-RELIDTEVSYLHMLQLCASDIRSRLQQLPQGDL 68
S S R A + L R+ V EL TE Y+ L+ S R+ Q +
Sbjct: 2 SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV 61
Query: 69 D---------VLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYK 119
D +LFSNI+DI+ V+ FL ++E E Q VG FL F+++ ++Y
Sbjct: 62 DKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKF-RIYD 120
Query: 120 VYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLL 179
YC+++++A L+ K ++ + + + L LV P+QRI +YPL+L
Sbjct: 121 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180
Query: 180 QKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKE 218
+++L+ T S Y + A+ A++ V +NINE K + E
Sbjct: 181 KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQME 219
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 87.0 bits (214), Expect = 5e-17
Identities = 65/219 (29%), Positives = 106/219 (48%), Gaps = 11/219 (5%)
Query: 10 SSRSGSPDREGRASEDRSLLHQRLAV-RELIDTEVSYLHMLQLCASDIRSRLQQLPQGDL 68
S S R A + L R+ V EL TE Y+ L+ S R+ Q +
Sbjct: 2 SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV 61
Query: 69 D---------VLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYK 119
D +LFSNI+DI+ V+ FL ++E E Q VG FL F+++ ++Y
Sbjct: 62 DKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKF-RIYD 120
Query: 120 VYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLL 179
YC+++++A L+ K ++ + + + L LV P+QRI +YPL+L
Sbjct: 121 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180
Query: 180 QKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKE 218
+++L+ T S Y + A+ A++ V +NINE K + E
Sbjct: 181 KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQME 219
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 84.0 bits (206), Expect = 4e-16
Identities = 55/207 (26%), Positives = 101/207 (48%), Gaps = 8/207 (3%)
Query: 20 GRASEDRSLLHQRLAVRELIDTEVSYL-HMLQLCASDI---RSRLQQLPQGDLDVLFSNI 75
GR ++R + + + E++ TE Y+ H+ +C + R R L V+F NI
Sbjct: 94 GRPLQNRDQMRANV-INEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNI 152
Query: 76 DDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTY 135
+DI + F+ DL++ + ++ + +G FLE Q+ +Y YC ++ A + +
Sbjct: 153 EDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYCNNHLDACMELSKL 211
Query: 136 RKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPV 195
K+ Q + ++ Q + L+ P+Q+I +YPL L ++L+ T D S Y
Sbjct: 212 MKDSRYQHFFEAC--RLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRY 269
Query: 196 LQRAVSALQDVNTNINEYKMRKEVASK 222
+ A++ +++V INE K R E K
Sbjct: 270 VAAALAVMRNVTQQINERKRRLENIDK 296
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 82.4 bits (202), Expect = 1e-15
Identities = 67/259 (25%), Positives = 125/259 (48%), Gaps = 17/259 (6%)
Query: 6 ADEPSSRSGSPDREGRASEDRSLLHQRLA--VRELIDTEVSYL-HMLQLCASDIRS---R 59
AD+ + +G+ E +E +S Q + E++ TE Y+ H+ +C +R R
Sbjct: 258 ADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKR 317
Query: 60 LQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYK 119
+ L +F NI+DI + F+ L++ ++E + +G FLE Q + Q+Y
Sbjct: 318 ADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADF-QIYS 376
Query: 120 VYCASYDQALLLVDTYRKEPELQRHIQGIVEA--VVPQAGSSGLSFLLVIPLQRITRYPL 177
YC ++ A + + K L +++ EA ++ + L L+ P+Q+I +YPL
Sbjct: 377 EYCNNHPNACVELSRLTK---LSKYVY-FFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
Query: 178 LLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKE----VASKYTKVEQLTLRE 233
L ++L+ T P + ++ A+ A+++V INE K R E +A + +E +
Sbjct: 433 QLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGED 492
Query: 234 RLARINTHTLSKKTTRLSQ 252
L R + S + TR++Q
Sbjct: 493 LLVRSSELIYSGELTRVTQ 511
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 82.4 bits (202), Expect = 1e-15
Identities = 67/259 (25%), Positives = 125/259 (48%), Gaps = 17/259 (6%)
Query: 6 ADEPSSRSGSPDREGRASEDRSLLHQRLA--VRELIDTEVSYL-HMLQLCASDIRS---R 59
AD+ + +G+ E +E +S Q + E++ TE Y+ H+ +C +R R
Sbjct: 258 ADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKR 317
Query: 60 LQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYK 119
+ L +F NI+DI + F+ L++ ++E + +G FLE Q + Q+Y
Sbjct: 318 ADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADF-QIYS 376
Query: 120 VYCASYDQALLLVDTYRKEPELQRHIQGIVEA--VVPQAGSSGLSFLLVIPLQRITRYPL 177
YC ++ A + + K L +++ EA ++ + L L+ P+Q+I +YPL
Sbjct: 377 EYCNNHPNACVELSRLTK---LSKYVY-FFEACRLLQKMIDISLDGFLLTPVQKICKYPL 432
Query: 178 LLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKE----VASKYTKVEQLTLRE 233
L ++L+ T P + ++ A+ A+++V INE K R E +A + +E +
Sbjct: 433 QLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGED 492
Query: 234 RLARINTHTLSKKTTRLSQ 252
L R + S + TR++Q
Sbjct: 493 LLVRSSELIYSGELTRVTQ 511
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 77.0 bits (188), Expect = 5e-14
Identities = 64/242 (26%), Positives = 110/242 (45%), Gaps = 23/242 (9%)
Query: 3 KHGADEPSSR----------SGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLC 52
+ ADE S R +G+P ++ LL+ V+E+++TE +Y+ L+
Sbjct: 76 QQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSI 135
Query: 53 ASDIRSRLQ---QLPQG--DLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIF 107
D ++ +LP G + LF NI DI NS L DL+ E + F
Sbjct: 136 VEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC----ENDPVAIAECF 191
Query: 108 LEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVI 167
+ EE +Y YC +Y +++ ++ + L + + E + S L L+
Sbjct: 192 VSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETL---KHSLPLGSYLLK 247
Query: 168 PLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVE 227
P+QRI +Y LLL +I + D Y V+ A+ +Q V +IN+ K + E A + +++
Sbjct: 248 PVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQ 307
Query: 228 QL 229
L
Sbjct: 308 SL 309
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 77.0 bits (188), Expect = 5e-14
Identities = 55/207 (26%), Positives = 104/207 (50%), Gaps = 7/207 (3%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQ- 90
+ ELI TE Y+ LQL + R+ + L +G++ ++F N ++I N++ L L+
Sbjct: 1187 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1246
Query: 91 -ETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIV 149
+ E+ VQ++G+I ++ + + A LL ++ + + ++ +
Sbjct: 1247 RKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKL- 1305
Query: 150 EAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTN 209
A P+ LS L+ P+QRITRYPLL++ ILENT + + L+ A+ +++ +
Sbjct: 1306 -ASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQ 1364
Query: 210 INEYKMRKEVASKYTKVEQLTLRERLA 236
+NE KE + + ++ E LA
Sbjct: 1365 VNEGVREKENSDRLEWIQAHVQCEGLA 1391
Score = 52.4 bits (124), Expect = 1e-06
Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 36/157 (22%)
Query: 509 KLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGH-----RGYVPAGK 563
++ QVTS +G+ L+L GQ++ IL+ K SG W + +G+ PA
Sbjct: 1029 EIAQVTSAYVASGSEQLSLAPGQLILILK----KNTSGWWQGELQARGKKRQKGWFPASH 1084
Query: 564 LQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSL 623
++L + PS+E P+ + QVIA Y + A + E+S
Sbjct: 1085 VKL--LGPSSERA---------------------TPAFHPVCQVIAMYDYAANNEDELSF 1121
Query: 624 QAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL 660
GQ + ++ D P+W E+NG G PS ++
Sbjct: 1122 SKGQLINVMNKDD----PDWWQGEINGVTGLFPSNYV 1154
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 77.0 bits (188), Expect = 5e-14
Identities = 55/207 (26%), Positives = 104/207 (50%), Gaps = 7/207 (3%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQ- 90
+ ELI TE Y+ LQL + R+ + L +G++ ++F N ++I N++ L L+
Sbjct: 1214 IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRV 1273
Query: 91 -ETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIV 149
+ E+ VQ++G+I ++ + + A LL ++ + + ++ +
Sbjct: 1274 RKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKL- 1332
Query: 150 EAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTN 209
A P+ LS L+ P+QRITRYPLL++ ILENT + + L+ A+ +++ +
Sbjct: 1333 -ASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQ 1391
Query: 210 INEYKMRKEVASKYTKVEQLTLRERLA 236
+NE KE + + ++ E LA
Sbjct: 1392 VNEGVREKENSDRLEWIQAHVQCEGLA 1418
Score = 52.4 bits (124), Expect = 1e-06
Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 36/157 (22%)
Query: 509 KLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGH-----RGYVPAGK 563
++ QVTS +G+ L+L GQ++ IL+ K SG W + +G+ PA
Sbjct: 1056 EIAQVTSAYVASGSEQLSLAPGQLILILK----KNTSGWWQGELQARGKKRQKGWFPASH 1111
Query: 564 LQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSL 623
++L + PS+E P+ + QVIA Y + A + E+S
Sbjct: 1112 VKL--LGPSSERA---------------------TPAFHPVCQVIAMYDYAANNEDELSF 1148
Query: 624 QAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL 660
GQ + ++ D P+W E+NG G PS ++
Sbjct: 1149 SKGQLINVMNKDD----PDWWQGEINGVTGLFPSNYV 1181
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/213 (26%), Positives = 109/213 (51%), Gaps = 7/213 (3%)
Query: 29 LHQRLAVRELIDTEVSYLHMLQLCAS---DIRSRLQQLPQGDLDVLFSNIDDIIKVNSRF 85
+ ++ A+ E+ E + L+L D +L + + +L +F ++D I ++
Sbjct: 173 IRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDL 232
Query: 86 LHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHI 145
L + E A+K + V+ +G+I + + L Y+ YC++ A L+D +++P +Q +
Sbjct: 233 LTRIGE-ATKPDGTVEQIGHILVSWLPRLN-AYRGYCSNQLAAKALLDQKKQDPRVQDFL 290
Query: 146 QGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQD 205
Q +E+ P + L L IP R+ +YPLLL++IL++T + +L+ A+ +Q
Sbjct: 291 QRCLES--PFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQG 348
Query: 206 VNTNINEYKMRKEVASKYTKVEQLTLRERLARI 238
V ++IN K E K+E L ++R RI
Sbjct: 349 VLSDINLKKGESECQYYIDKLEYLDEKQRDPRI 381
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 72.0 bits (175), Expect = 2e-12
Identities = 57/213 (26%), Positives = 109/213 (51%), Gaps = 7/213 (3%)
Query: 29 LHQRLAVRELIDTEVSYLHMLQLCAS---DIRSRLQQLPQGDLDVLFSNIDDIIKVNSRF 85
+ ++ A+ E+ E + L+L D +L + + +L +F ++D I ++
Sbjct: 119 IRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDL 178
Query: 86 LHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHI 145
L + E A+K + V+ +G+I + + L Y+ YC++ A L+D +++P +Q +
Sbjct: 179 LTRIGE-ATKPDGTVEQIGHILVSWLPRLN-AYRGYCSNQLAAKALLDQKKQDPRVQDFL 236
Query: 146 QGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQD 205
Q +E+ P + L L IP R+ +YPLLL++IL++T + +L+ A+ +Q
Sbjct: 237 QRCLES--PFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQG 294
Query: 206 VNTNINEYKMRKEVASKYTKVEQLTLRERLARI 238
V ++IN K E K+E L ++R RI
Sbjct: 295 VLSDINLKKGESECQYYIDKLEYLDEKQRDPRI 327
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/214 (27%), Positives = 105/214 (49%), Gaps = 13/214 (6%)
Query: 16 PDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ-LPQGDLDVLFSN 74
P + G +D+ + + E+ +TE Y L+ + S L+ L D+ +F N
Sbjct: 183 PMKMGMTEDDK----RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFIN 238
Query: 75 IDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDT 134
++D+IKV+ FL + + + +FL+F+E L +Y YC+ + A ++
Sbjct: 239 LEDLIKVHHSFLRAIDVSVMVGGSTL---AKVFLDFKERL-LIYGEYCSHMEHAQNTLNQ 294
Query: 135 YRKEPELQRHIQGIVEAVVP-QAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAY 193
E R Q + E + Q G L LLV+P+QR+ +Y LLL+++L ++ +
Sbjct: 295 LLASREDFR--QKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPER 351
Query: 194 PVLQRAVSALQDVNTNINEYKMRKEVASKYTKVE 227
L+ A+ A+QD+ INE K KE K ++ +
Sbjct: 352 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQ 385
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 70.9 bits (172), Expect = 4e-12
Identities = 53/190 (27%), Positives = 102/190 (53%), Gaps = 9/190 (4%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQ- 90
+ ELI TE +Y++ LQL + L + L + ++ ++F N ++I N + L L+
Sbjct: 1242 IHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRV 1301
Query: 91 -ETASKEEEQVQLVGNIFLEFQEELEQVYKVYCA-SYDQALLLVDTYRKEPELQRHIQGI 148
+ S E+ V+++G+I L Q Q Y +C+ + A L+ + P+ + ++ +
Sbjct: 1302 RKKMSGEKMPVKMIGDI-LSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRL 1360
Query: 149 VEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNT 208
A+ P+ LS ++ P+QR+TRYPL+++ ILENT + + L+ A+ +++ +
Sbjct: 1361 --AMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCS 1418
Query: 209 NINEYKMRKE 218
+NE KE
Sbjct: 1419 QVNEGVREKE 1428
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/158 (29%), Positives = 72/158 (45%), Gaps = 31/158 (19%)
Query: 509 KLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRW----LVDTGGHR--GYVPAG 562
++ QV ++ + TG LTL GQ++ I K N G W L G R G+ PA
Sbjct: 1077 EIAQVIASYTATGPEQLTLAPGQLILI-----RKKNPGGWWEGELQARGKKRQIGWFPAN 1131
Query: 563 KLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVS 622
++L G +K +TP P ++ + QVI Y + A++ E++
Sbjct: 1132 YVKLL-----------SPGTSK----ITPTEPPKST-ALAAVCQVIGMYDYTAQNDDELA 1175
Query: 623 LQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFL 660
GQ + +L +D P+W EVNGQ G PS ++
Sbjct: 1176 FNKGQIINVLNKED----PDWWKGEVNGQVGLFPSNYV 1209
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/108 (29%), Positives = 49/108 (45%), Gaps = 9/108 (8%)
Query: 570 VPSAEELRRQAGLNKDPRCLT-PEPSPALVPSIPTMN-QVIAAYPFVARSSHEVSLQAGQ 627
VPSA +LR+++ P T PSP L Q A YP+ A+ + ++
Sbjct: 881 VPSAGQLRQRSAFT--PATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKND 938
Query: 628 PVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLARARSPVLWGWSLPS 675
+T+LE QD W EV GQ+G+ P ++ P+ S+ S
Sbjct: 939 VITVLEQQDM-----WWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDS 981
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 70.5 bits (171), Expect = 5e-12
Identities = 56/193 (29%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 37 ELIDTEVSYLHMLQLCASDIRSRLQQ-LPQGDLDVLFSNIDDIIKVNSRFLHDLQETASK 95
E+ +TE Y L+ + S L+ L D+ +F N++D+IKV+ FL + +
Sbjct: 205 EIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMV 264
Query: 96 EEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVP- 154
+ +FL+F+E L +Y YC+ + A ++ E R Q + E +
Sbjct: 265 GGSTL---AKVFLDFKERL-LIYGEYCSHMEHAQNTLNQLLASREDFR--QKVEECTLKV 318
Query: 155 QAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYK 214
Q G L LLV+P+QR+ +Y LLL+++L ++ + L+ A+ A+QD+ INE K
Sbjct: 319 QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAMYINEVK 377
Query: 215 MRKEVASKYTKVE 227
KE K ++ +
Sbjct: 378 RDKETLRKISEFQ 390
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 69.7 bits (169), Expect = 8e-12
Identities = 45/192 (23%), Positives = 99/192 (51%), Gaps = 12/192 (6%)
Query: 36 RELIDTEVSYLHMLQLCASDIRSRLQQ--------LPQGDLDVLFSNIDDIIKVNSRFLH 87
+EL TE +Y+++L + L++ L ++ +F +I DI V+++
Sbjct: 427 KELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTKIKD 486
Query: 88 DLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQAL-LLVDTYRKEPELQRHIQ 146
DL++ +E + +G+IFL++ ++L + Y + ++ + ++ +++P ++
Sbjct: 487 DLEDLIVNWDES-KSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLK 545
Query: 147 GIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDV 206
+ P+ G L LL+ P+QR+ LLL + ++T + L++A+ +L++V
Sbjct: 546 --INQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEV 603
Query: 207 NTNINEYKMRKE 218
T+INE K + E
Sbjct: 604 MTHINEDKRKTE 615
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 68.9 bits (167), Expect = 1e-11
Identities = 47/225 (20%), Positives = 116/225 (51%), Gaps = 20/225 (8%)
Query: 24 EDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQ---QLPQGDLDVLFSNIDDIIK 80
+++ ++ ++ + EL+ TE+ ++ L + + R ++ QL +D +F +D++++
Sbjct: 843 QEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLE 902
Query: 81 VNSRFLHDLQE------TASKEEEQVQLVGNIFLE-FQEE----LEQVYKVYCASYDQAL 129
++ F + ++E S + +G+I ++ F EE ++++Y +C + +A+
Sbjct: 903 IHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAV 962
Query: 130 LLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPD 189
L ++ + Q I+ ++ A G+ +++ QRIT+YP+L+++IL+ T
Sbjct: 963 NLFKELQQNKKFQNFIKLRNSNLL--ARRRGIPECILLVTQRITKYPVLVERILQYTKER 1020
Query: 190 ASAYPVLQRAVSALQD----VNTNINEYKMRKEVASKYTKVEQLT 230
+ L++A+ ++D V+ +NEY+ ++ K+E T
Sbjct: 1021 TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKT 1065
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/282 (20%), Positives = 129/282 (45%), Gaps = 20/282 (7%)
Query: 8 EPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQ---QLP 64
E S S + D + R ++ ++ + EL+ TEV ++ L++ LQ Q
Sbjct: 237 EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFS 296
Query: 65 QGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQ-------VQLVGNIFL-----EFQE 112
+ LF DD+++ +S FL L+E + E+ +Q +G++ + E E
Sbjct: 297 SKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGE 356
Query: 113 ELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAV--VPQAGSSGLSFLLVIPLQ 170
+++ Y V+C+ +++A V Y+ + + Q +++ + G+ +++ Q
Sbjct: 357 RMKEKYGVFCSGHNEA---VSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQ 413
Query: 171 RITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLT 230
RIT+YP+L+++I++NT Y L +A++ ++D+ + ++ E + ++
Sbjct: 414 RITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKM 473
Query: 231 LRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDL 272
+ +++ +K L + L E L +T D+
Sbjct: 474 DLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDI 515
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/282 (20%), Positives = 129/282 (45%), Gaps = 20/282 (7%)
Query: 8 EPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQ---QLP 64
E S S + D + R ++ ++ + EL+ TEV ++ L++ LQ Q
Sbjct: 79 EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFS 138
Query: 65 QGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQ-------VQLVGNIFL-----EFQE 112
+ LF DD+++ +S FL L+E + E+ +Q +G++ + E E
Sbjct: 139 SKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGE 198
Query: 113 ELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAV--VPQAGSSGLSFLLVIPLQ 170
+++ Y V+C+ +++A V Y+ + + Q +++ + G+ +++ Q
Sbjct: 199 RMKEKYGVFCSGHNEA---VSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQ 255
Query: 171 RITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLT 230
RIT+YP+L+++I++NT Y L +A++ ++D+ + ++ E + ++
Sbjct: 256 RITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKM 315
Query: 231 LRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDL 272
+ +++ +K L + L E L +T D+
Sbjct: 316 DLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDI 357
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 67.8 bits (164), Expect = 3e-11
Identities = 53/196 (27%), Positives = 100/196 (51%), Gaps = 10/196 (5%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ-LPQGDLDVLFSNIDDIIKVNSRFLHDLQETA 93
+RE+ TE Y L LQ+ L D++++F NI+D+++V++ FL +++E
Sbjct: 199 LREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEAL 258
Query: 94 SKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVV 153
+ +F++++E VY YC+ + A +D E +Q +E
Sbjct: 259 GTPG--AANLYQVFIKYKERF-LVYGRYCSQVESASKHLDRVAAARE---DVQMKLEECS 312
Query: 154 PQA--GSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNIN 211
+A G L LL++P+QR+ +Y LLLQ+++++T +A L+ A+ A++D+ +N
Sbjct: 313 QRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALDAMRDLAQCVN 371
Query: 212 EYKMRKEVASKYTKVE 227
E K E + T +
Sbjct: 372 EVKRDNETLRQITNFQ 387
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 67.0 bits (162), Expect = 5e-11
Identities = 70/266 (26%), Positives = 125/266 (46%), Gaps = 33/266 (12%)
Query: 9 PSSRSGSP-DREG------RASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQ 61
PS +S SP D G R D L R + EL++TE +Y+ L LQ
Sbjct: 1014 PSDQSPSPQDSTGPQLATMRQLSDADKL--RKVICELLETERTYVKDLNCLMERYLKPLQ 1071
Query: 62 Q---LPQGDLDVLFSNIDDIIKVNSRFLHDLQ------------ETASKEEEQVQLVGNI 106
+ L Q +LDVLF N+ ++++ FL L+ E + ++ + +G
Sbjct: 1072 KETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGS 1131
Query: 107 FLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVP-QAGSSGLSFLL 165
FL + + + +Y +CAS+ + V + + + ++A P Q SS L L
Sbjct: 1132 FLYYADRFK-LYSAFCASHTK----VPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYL 1186
Query: 166 VIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINE-YKMRKEVASKYT 224
+ P+QRI +YPLLL+++ T ++ + L A+ + V ++INE K+ +E + +
Sbjct: 1187 IKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFD 1246
Query: 225 KV--EQLTLRERLARINTHTLSKKTT 248
++ EQ ++ +A ++ L TT
Sbjct: 1247 QLIAEQTGEKKEVADLSMGDLLLHTT 1272
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 67.0 bits (162), Expect = 5e-11
Identities = 52/200 (26%), Positives = 98/200 (49%), Gaps = 16/200 (8%)
Query: 36 RELIDTEVSYLHMLQLCASDIRSRLQQ-----LPQGDLDVLFSNIDDIIKVNSRFLHDLQ 90
RE+++TE +Y+ L+ D L L + LF+NI+DI + +S L DL+
Sbjct: 108 REIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLE 167
Query: 91 ETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVE 150
++S + F++ E+ + +Y +YC +Y +L L+ P +Q E
Sbjct: 168 NSSSAGG-----IAECFVQRSEDFD-IYTLYCMNYPSSLALLRELSLSPPAALWLQ---E 218
Query: 151 AVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTV--PDASAYPVLQRAVSALQDVNT 208
S L L+ P+QRI +Y LLLQ++ ++ P +++ A+ ++ V
Sbjct: 219 RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAW 278
Query: 209 NINEYKMRKEVASKYTKVEQ 228
IN+ K ++E A++ +V++
Sbjct: 279 YINDMKRKQEHAARLQEVQR 298
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 67.0 bits (162), Expect = 5e-11
Identities = 58/207 (28%), Positives = 96/207 (46%), Gaps = 20/207 (9%)
Query: 34 AVRELIDTEVSYLHMLQLC------ASDIRSRLQQLPQGDLDVLFSNIDDIIKVNSRFLH 87
A+ E++ +E SY H L + + ++R+ + Q+ L FSNI D++ + RF
Sbjct: 288 AMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHL---FSNILDVLGASQRFFE 344
Query: 88 DLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCAS--YDQALL--LVDTYRKEPELQR 143
DL++ K + V+ + +I E E+ Y YC++ Y Q L L+ + E R
Sbjct: 345 DLEQR-HKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALR 403
Query: 144 HIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSAL 203
I+ P G + L++P+QR+TR PLL+ + T + Y RA+ A+
Sbjct: 404 EIERR-----PACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAI 458
Query: 204 QDVNTNINEYKMRKE-VASKYTKVEQL 229
+ NE R E + YT QL
Sbjct: 459 SKLVRQCNEGAHRMERMEQMYTLHTQL 485
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/187 (27%), Positives = 98/187 (52%), Gaps = 12/187 (6%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQE 91
+ EL TE S+L L++ R+++ +P+ +L LF N+ ++I++++ + +++
Sbjct: 779 INELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKK 838
Query: 92 TASKEEEQVQLVGNIFLE-----FQEELEQVYKVYCASYDQALLLVDT-YRKEPELQRHI 145
+E ++ + ++ L +EEL+QV +C+ AL L+ T RKE Q +
Sbjct: 839 LR-EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFM 897
Query: 146 QGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQD 205
Q PQ L L++ +QR+T+YPLLL+ I+++T S + L RA ++
Sbjct: 898 QEAESH--PQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 955
Query: 206 VNTNINE 212
+ +NE
Sbjct: 956 ILKYVNE 962
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 65.9 bits (159), Expect = 1e-10
Identities = 51/187 (27%), Positives = 98/187 (52%), Gaps = 12/187 (6%)
Query: 35 VRELIDTEVSYLHMLQLCASDIRSRLQQ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQE 91
+ EL TE S+L L++ R+++ +P+ +L LF N+ ++I++++ + +++
Sbjct: 739 INELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKK 798
Query: 92 TASKEEEQVQLVGNIFLE-----FQEELEQVYKVYCASYDQALLLVDT-YRKEPELQRHI 145
+E ++ + ++ L +EEL+QV +C+ AL L+ T RKE Q +
Sbjct: 799 LR-EEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFM 857
Query: 146 QGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQD 205
Q PQ L L++ +QR+T+YPLLL+ I+++T S + L RA ++
Sbjct: 858 QEAESH--PQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCRE 915
Query: 206 VNTNINE 212
+ +NE
Sbjct: 916 ILKYVNE 922
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 65.9 bits (159), Expect = 1e-10
Identities = 62/247 (25%), Positives = 116/247 (46%), Gaps = 26/247 (10%)
Query: 4 HGADEPSSRSGSPDRE-GRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ 62
+G + P P R R D L R ++EL+DTE SY+ L LQ
Sbjct: 1074 NGMEGPRENQDPPPRPLARHLSDADRL--RKVIQELVDTEKSYVKDLSCLFELYLEPLQN 1131
Query: 63 ---LPQGDLDVLFSNIDDIIKVNSRFLHDLQ------------ETASKEEEQVQLVGNIF 107
L Q +++ LF ++ ++++ FL L+ ET S+ + + +G F
Sbjct: 1132 ETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSF 1191
Query: 108 LEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVP-QAGSSGLSFLLV 166
L + + + +Y +CA++ + V + + + + ++A P + SS L L+
Sbjct: 1192 LYYADHFK-LYSGFCANH----IKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLI 1246
Query: 167 IPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKV 226
P+QR+ +YPLLL++++ T ++ + L A+ A++ V ++INE M+K T
Sbjct: 1247 KPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINE--MQKIYEDYGTVF 1304
Query: 227 EQLTLRE 233
+QL +
Sbjct: 1305 DQLVAEQ 1311
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/185 (25%), Positives = 97/185 (52%), Gaps = 10/185 (5%)
Query: 37 ELIDTEVSYLHMLQLCASDIRSRLQQ-LPQGDLDVLFSNIDDIIKVNSRFLHDLQETASK 95
E+ TE Y L+ + L++ L + D +F NI +++K++ + ++ ++
Sbjct: 199 EIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELVKLHRNLMQEIHDSIVN 258
Query: 96 EEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQ 155
+ +Q + +F+ ++E L +Y YC+ + A+ +D K E ++ +E +
Sbjct: 259 KNDQN--LYQVFINYKERLV-IYGQYCSGVESAISSLDYISKTKE---DVKLKLEECSKR 312
Query: 156 A--GSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEY 213
A G L LLV+P+QR+ +Y LLLQ+++++T D + L+ A+ A++D+ +NE
Sbjct: 313 ANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT-DPTEKANLKLALDAMKDLAQYVNEV 371
Query: 214 KMRKE 218
K E
Sbjct: 372 KRDNE 376
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,210,463
Number of Sequences: 37866
Number of extensions: 1249858
Number of successful extensions: 4432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 4138
Number of HSP's gapped (non-prelim): 372
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.