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Search of human proteins with 78190492
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78190492 retinitis pigmentosa GTPase regulator isoform C
[Homo sapiens]
(1152 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 2345 0.0
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 1289 0.0
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 215 2e-55
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 176 9e-44
gi|7657152 hect domain and RLD 3 [Homo sapiens] 162 2e-39
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 160 8e-39
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 154 4e-37
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 154 4e-37
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 149 1e-35
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 149 1e-35
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 149 2e-35
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 140 5e-33
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 140 5e-33
gi|61563742 hect domain and RLD 6 [Homo sapiens] 139 2e-32
gi|24415404 MDN1, midasin homolog [Homo sapiens] 138 3e-32
gi|148746195 trichohyalin [Homo sapiens] 138 3e-32
gi|4504487 histidine rich calcium binding protein precursor [Hom... 137 5e-32
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 136 1e-31
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 136 1e-31
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 136 1e-31
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 136 1e-31
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 136 1e-31
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 133 1e-30
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 131 3e-30
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 131 3e-30
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 131 3e-30
gi|126032348 hect domain and RLD 2 [Homo sapiens] 129 2e-29
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 126 1e-28
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 122 2e-27
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 122 3e-27
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 2345 bits (6076), Expect = 0.0
Identities = 1152/1152 (100%), Positives = 1152/1152 (100%)
Query: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG
Sbjct: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE
Sbjct: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
Query: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI
Sbjct: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
Query: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH
Sbjct: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Query: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD
Sbjct: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
Query: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK
Sbjct: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
Query: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE
Sbjct: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
Query: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG
Sbjct: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
Query: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCE 660
IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCE
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCE 660
Query: 661 EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ 720
EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ
Sbjct: 661 EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ 720
Query: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780
KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780
Query: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
Query: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE 960
EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE 960
Query: 961 EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020
EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE
Sbjct: 961 EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020
Query: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
Query: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKF 1140
DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKF
Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKF 1140
Query: 1141 WNNVLPHYLELK 1152
WNNVLPHYLELK
Sbjct: 1141 WNNVLPHYLELK 1152
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 1289 bits (3336), Expect = 0.0
Identities = 650/709 (91%), Positives = 657/709 (92%), Gaps = 27/709 (3%)
Query: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG
Sbjct: 1 MREPEELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG
Sbjct: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV
Sbjct: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
Query: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE
Sbjct: 181 CVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE 240
Query: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI
Sbjct: 241 IPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYI 300
Query: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH
Sbjct: 301 SCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Query: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD
Sbjct: 361 MVVFAAPHRGVAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPD 420
Query: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK
Sbjct: 421 SFSMRRTLPPIEGTLGLSACFLPNSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTK 480
Query: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE
Sbjct: 481 EAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTE 540
Query: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG
Sbjct: 541 NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNG 600
Query: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVS----------------------E 638
IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAE E
Sbjct: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVE 660
Query: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME 687
K K+VG+ E P G T GAE D+ + + K + +E
Sbjct: 661 SKKKTVGDDESVPTGYHSKT-----EGAERTNDDSSAETIEKKEKANLE 704
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/249 (24%), Positives = 108/249 (43%), Gaps = 21/249 (8%)
Query: 621 EKTEILSDDLTDKAEVSEGKA-KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
E+ + L D++T +AE+ +S+GE D + +S + + +K +K
Sbjct: 469 EEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSL---NSNEKSLKLSPVQKQKK 525
Query: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG-GEEEHGEG 738
+ GE+ + + L E ++ E +E E ++G K Q + +G +
Sbjct: 526 QQTIGELTQ----DTALTENDD----SDEYEEMSEMKEG--KACKQHVSQGIFMTQPATT 575
Query: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798
E D E E +E EG E+ +G +E E+E E E + G++EK E D +
Sbjct: 576 IEAFSDEEVEIPEEKEGAEDSKGNGIE-EQEVEANEENVKVHGGRKEKTEILSDDLTDKA 634
Query: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEE-GEGEEEEGEGEEEEGEGK 857
E+ E E+ + +V+ EE E E +++ G++E G + EG E +
Sbjct: 635 EDHEFSKTEELKLEDVD----EEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDS 690
Query: 858 GEEEGEEGE 866
E E+ E
Sbjct: 691 SAETIEKKE 699
Score = 44.3 bits (103), Expect = 7e-04
Identities = 57/234 (24%), Positives = 96/234 (41%), Gaps = 17/234 (7%)
Query: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
+++ ++ GE ++ E ++ E E E EG+ ++ +G E +
Sbjct: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
Query: 928 GEGE-GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
E E EE+EG ED +G G EE+ E E EE + G + + E + + E+
Sbjct: 582 EEVEIPEEKEGA---EDSKGNGIEEQ-EVEANEENVKVHGGRKEKTEILSDDLTDKAEDH 637
Query: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE- 1045
E EE E+ +EE E E +++ G+ E G + EG E ++ E
Sbjct: 638 EFSKTEELKLEDVDEEINAENV---ESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAET 694
Query: 1046 -REKEGEGEENRRNREEEEEEEGKYQETGE-------EENERQDGEEYKKVSKI 1091
+KE E R E E +G + + E +E ++ KK KI
Sbjct: 695 IEKKEKANLEERAICEYNENPKGYMLDDADSSSLEILENSETTPSKDMKKTKKI 748
Score = 42.4 bits (98), Expect = 0.003
Identities = 45/184 (24%), Positives = 75/184 (40%), Gaps = 5/184 (2%)
Query: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR 804
++++++ GE ++ E + E EE KE +A K+ + E
Sbjct: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS- 580
Query: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE---- 860
EE E E EG E +G G E+E E E + G +E+ E ++ K E+
Sbjct: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEFS 640
Query: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920
+ EE + E+ EE E E + + G++E G + EG + E E + K
Sbjct: 641 KTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEK 700
Query: 921 GEEE 924
E
Sbjct: 701 ANLE 704
Score = 42.0 bits (97), Expect = 0.003
Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 28/204 (13%)
Query: 606 VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSG 665
+ +NE+++K+ +K+K + +LT ++E E E+ E + C++ S
Sbjct: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSD--EYEEMSEMKEGKACKQHVSQ 565
Query: 666 A----------EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKER 715
E + DEE E E+ +G + + G E+E+ EE K G +E+ E
Sbjct: 566 GIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEI 625
Query: 716 EQGHQKERNQEMEEGGEEE-HGEGEEEEGDREEEEEKEGEGKEEGEGEEV-EGEREKEEG 773
++ ++ E EE E +EE + E E K+ K G+ E V G K EG
Sbjct: 626 LSDDLTDKAEDHEFSKTEELKLEDVDEEINAENVESKK---KTVGDDESVPTGYHSKTEG 682
Query: 774 ERK-----------KEERAGKEEK 786
+ K+E+A EE+
Sbjct: 683 AERTNDDSSAETIEKKEKANLEER 706
Score = 38.1 bits (87), Expect = 0.049
Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 12/136 (8%)
Query: 996 EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN 1055
E E EE EG E+ +G G EE+ EVE E + G G +E+ E ++ + E
Sbjct: 583 EVEIPEEKEGAEDSKGNGIEEQ--EVEANEENVKVHG-GRKEKTEILSDDLTDKAE---- 635
Query: 1056 RRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNG 1115
+ E + EE K ++ EE N ++ E KK SV G H + TN +
Sbjct: 636 --DHEFSKTEELKLEDVDEEIN-AENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSA 692
Query: 1116 K--EQRSKMPVQSKRL 1129
+ E++ K ++ + +
Sbjct: 693 ETIEKKEKANLEERAI 708
Score = 33.5 bits (75), Expect = 1.2
Identities = 44/170 (25%), Positives = 70/170 (41%), Gaps = 22/170 (12%)
Query: 860 EEGEEGEGEEEGEEGEGEG-EEEEGEG----------EGEEEGEGEGEEEEGEGEGEEEG 908
E + E EE E EG+ ++ +G E + E E EE+ EG E+
Sbjct: 540 ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEK---EGAEDS 596
Query: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE------EEGEWEGEEEEG 962
+G G EE+ E + EE + G G +E+ E +D + E+ EE + E +EE
Sbjct: 597 KGNGIEEQ-EVEANEENVKVHG-GRKEKTEILSDDLTDKAEDHEFSKTEELKLEDVDEEI 654
Query: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
E E + + E + EG E ++ E E +E+ E
Sbjct: 655 NAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLE 704
Score = 32.7 bits (73), Expect = 2.0
Identities = 41/165 (24%), Positives = 65/165 (39%), Gaps = 24/165 (14%)
Query: 855 EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914
E +EE E E +E E+ +G G EE+ E E EE + G G +
Sbjct: 577 EAFSDEEVEIPEEKEGAEDSKGNGIEEQ---------EVEANEENVKVHG-------GRK 620
Query: 915 EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974
E+ E ++ ++ E + E + ED +EE E E + + G++E G
Sbjct: 621 EKTEILSDDLTDKAEDHEFSKTEELKLED-----VDEEINAENVESKKKTVGDDESVPTG 675
Query: 975 EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
+ EG E + E E +E+ EE E E +G
Sbjct: 676 YHSKTEGAERTNDDSSAE---TIEKKEKANLEERAICEYNENPKG 717
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 215 bits (547), Expect = 2e-55
Identities = 179/547 (32%), Positives = 262/547 (47%), Gaps = 61/547 (11%)
Query: 591 EGAEDSKGNGIEE----QEVEANEENVKVHGGRKEKT-----EILSDDLTDKAEVSEGKA 641
+GAE G G+ + E E E + +++ + K + ++ + K SE A
Sbjct: 1724 QGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSA 1783
Query: 642 KS-VGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
S +GEAE G+G E G +G + E+ +GE G G+ + G+ + AE
Sbjct: 1784 GSELGEAEQ----EGEGISERGETGGQGSGHEDNLQGEAAAG-GDQD---PGQSDGAEGI 1835
Query: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE 760
E + +GE Q + E + + E G+ + EGE + + E+ E E EG+ + E
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAE--------GDAQEAEGEAQP-ESEDVEAPEAEGEAQPE 1886
Query: 761 GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGE-- 818
E+VE + E + + E E + E + + E ETEG E + EG E + E
Sbjct: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
Query: 819 VEEGKGEREEEEE--EGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG 876
+E +G+ + E E E + EEE + E E+ E E E E + E EGE E+ E E
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQ-EAEGEAQPESEDVEAPEA 2005
Query: 877 EGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG-EGEGEEE 935
EGE +E E E + E +G + + EGE +E EGE ++ EG+ + E +G E E E E +
Sbjct: 2006 EGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065
Query: 936 EGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG------EGEGEEGEG-EGEEEEGEG 988
E EGE ++ EGE E + + +E EGE + E EG EGE ++ EG E E EGE
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
Query: 989 EGEEE-------EGEEEGEEEG------EGEEEGEGEGEEEEEGEVEG--EVEGEEG-EG 1032
+ E E EGE + E EG EGE + E EG E +E E E E+EG E E
Sbjct: 2126 QPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEA 2185
Query: 1033 EGEEEEGEEEGEEREKEGEGEENRR-----NREEEEEEEGKYQETGEEENERQDGEEYKK 1087
EGE + E E E EGE + EEE + E + ET E E E Q E +
Sbjct: 2186 EGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGET 2245
Query: 1088 VSKIKGS 1094
+ KGS
Sbjct: 2246 QGEKKGS 2252
Score = 209 bits (533), Expect = 9e-54
Identities = 176/543 (32%), Positives = 256/543 (47%), Gaps = 61/543 (11%)
Query: 546 EYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQE 605
E + M++ +EGK S G E E +E EG + G +
Sbjct: 1764 EGDAMAQEREGKTHNSETSAG--------------SELGEAEQEGEGISERGETGGQGSG 1809
Query: 606 VEANEENVKVHGGRKEKTEILSDDLTD-KAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSS 664
E N + GG ++ + SD +A +EG+A+ E + PE GD EG +
Sbjct: 1810 HEDNLQGEAAAGGDQDPGQ--SDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867
Query: 665 GAEHWQDEEREKGEKDKGRGEMERPGEG-EKELAEKEEWKKRDGEEQEQKEREQGHQKER 723
E E E + GE + E E AE E + +G E + E+E + E
Sbjct: 1868 ------QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETES 1921
Query: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGK 783
+ +E GE+E E E E EE +E EG+ + E E +E + +EE + + E+
Sbjct: 1922 VEALETEGEDEP-ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
Query: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE--EGEGEEEEGE 841
E + E + +GE + E + E E GE++E + E + E + E + + E E
Sbjct: 1981 EVEVETQEAEGEAQPESEDVEAPEAE-------GEMQEAEEEAQPESDGVEAQPKSEGEE 2033
Query: 842 GEEEEGEGEEEEGEGKGEEEGEEG-EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
+E EGE ++ EG+ + E +G E E EEE +E EGE +E EGE E E + + +E EG
Sbjct: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE-DVDAQEAEG 2092
Query: 901 EGEGEEEG----EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE 956
E + E EG E EGE ++ EG E E EGE + E E + EGE + E E
Sbjct: 2093 EAQPESEGVEAPEAEGEAQKAEGI---EAPETEGEAQPESEGIEAPEAEGEAQPESEGVE 2149
Query: 957 GEEEEGEGEGEEEGEGEGEEGEGEGEEE-------EGEGEGE-EEEGEEEGEEEGEGEEE 1008
++ EGE + E EG E +E E E + E E EGE + E EG E E EGE + E
Sbjct: 2150 AQDAEGEAQPESEGI-EAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPE 2208
Query: 1009 GEG----EGEEEEEGEVEGEVEGEEGEGEGE-EEEGEEEGEEREKEGEGEENRRNREEEE 1063
EG E EEE + E EG VE E EGE + E EGE +G EK+G + + + + EE
Sbjct: 2209 LEGVEAPEAEEEAQPEPEG-VETPEAEGEAQPESEGETQG---EKKGSPQVSLGDGQSEE 2264
Query: 1064 EEE 1066
E
Sbjct: 2265 ASE 2267
Score = 194 bits (493), Expect = 4e-49
Identities = 159/460 (34%), Positives = 221/460 (48%), Gaps = 36/460 (7%)
Query: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
E +E PE EG + G+E E E G ++ E + ++ E E +
Sbjct: 1833 EGIEAPEA-EGEAQPESEGVEAPEAE----------GDAQEAEGEAQPESEDVEAPEAEG 1881
Query: 642 KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
++ E+ED + + S GAE + E+ + E + +E GE E E E
Sbjct: 1882 EAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA-LETEGEDEPE---SEG 1937
Query: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
+ ++ EE Q+ Q + E +E EE E E+ E E E +E EG+ + E
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997
Query: 762 EEVEGEREKEEGERKK-EERAGKEEKGEEEGDQGEGEE-EETEGRGEEKEEGGEVEGGEV 819
E+VE + EGE ++ EE A E G E + EGEE +E EG ++ E + E V
Sbjct: 1998 EDVEAP--EAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGV 2055
Query: 820 EEGKGEREEEEEEGEGEEEEGEG--EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877
E + E E +E EGE +E EGE E E+ + +E EGE + E EG E E EGE + E
Sbjct: 2056 EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAP-EAEGEAQKAE 2114
Query: 878 G-EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG-EGEEEEGEGKGEEEGEEGEGEGEEE 935
G E E EGE + E EG E E EGE + E EG E ++ EGE + E EG E + EE
Sbjct: 2115 GIEAPETEGEAQPESEGI-EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
Query: 936 EGEGEG---EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE 992
+ E EG + EGE + E E E EGE + E EG E E E E + E E E
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGV-EAPEAEEEAQPEPEGVETPE 2232
Query: 993 EEGEEEGEEEGE--GEEEGE-----GEGEEEEEGEVEGEV 1025
EGE + E EGE GE++G G+G+ EE E V
Sbjct: 2233 AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPV 2272
Score = 191 bits (486), Expect = 3e-48
Identities = 162/494 (32%), Positives = 226/494 (45%), Gaps = 51/494 (10%)
Query: 632 DKAEVSEGKA-------KSVGEAEDG-----PEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
+ AEV+ GK ++V AE G +G G E+G +D++ + GE
Sbjct: 1704 EAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEA 1763
Query: 680 DKGRGEMERPGEGEK-------ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGE 732
+ ER G+ EL E E+ + E E + GH+ E GG+
Sbjct: 1764 EGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGD 1823
Query: 733 EEHGEGEEEEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
++ G+ + EG E E E + + EG E E EG+ ++ EGE + E E E EG
Sbjct: 1824 QDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESE--DVEAPEAEG 1881
Query: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851
+ + E E+ E E E E EG E E + E + E E E E EGE E E E
Sbjct: 1882 E-AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940
Query: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGE--EEGEGEGEEEEGEGEGEEEGE 909
+E E +E EG+ + E E E + EEE + E E E E E E +E EGE + E E
Sbjct: 1941 QEAEEAAQEA--EGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE 1998
Query: 910 G-EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG---EGEGEEEEGEWEGEEEEGEGE 965
E E EGE + EE + E +G E + + EGE+ EGE ++ EG+ + E +G
Sbjct: 1999 DVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD---AQPESDGV 2055
Query: 966 GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG------EGE----- 1014
E E E +E EGE +E EGE E E+ + + E EGE + E EG EGE
Sbjct: 2056 EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ-EAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 1015 ----EEEEGEVEGEVEG-EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKY 1069
E EGE + E EG E E EGE + E E ++ EGE + E +E EE
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
Query: 1070 QETGEEENERQDGE 1083
E E +GE
Sbjct: 2175 PELEGVEAPEAEGE 2188
Score = 177 bits (450), Expect = 4e-44
Identities = 153/529 (28%), Positives = 233/529 (44%), Gaps = 49/529 (9%)
Query: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGR---KEKTEILSDDLTDKAEVSEGKA 641
++ EE EG E ++V + R KE ++ + E ++G+A
Sbjct: 1646 QLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEA 1705
Query: 642 KSV--GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699
V G+ P EG G Q ++GE +G + R + + +L E
Sbjct: 1706 AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNR--DKDPKLGEA 1763
Query: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759
E G+ Q+ + H E + E G E+ GEG E G E +G G E+
Sbjct: 1764 E------GDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERG----ETGGQGSGHEDN 1813
Query: 760 -EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG-- 816
+GE G G ++ G+ +G +G E E EG + + EG E
Sbjct: 1814 LQGEAAAG---------------GDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAE 1857
Query: 817 GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG 876
G+ +E +GE + E E+ E E EGE + E + E E E + + E E E E +E +
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQP 1917
Query: 877 EGEEEEG-EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE 935
E E E E EGE+E E EG E + E +E EG+ + E + +E EE + E E+
Sbjct: 1918 ETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
Query: 936 EG---EGEGEDGEGEGEEEEG-----EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE 987
E E E ++ EGE + E E EGE +E E E + E +G + + EGEE + E
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQ-E 2036
Query: 988 GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047
EGE ++ E + + E +G E E E EE E EGEV+ EGE E E+ + + E E
Sbjct: 2037 VEGETQKTEGDAQPESDGVEAPEAE---EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
Query: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVK 1096
+ E E E E ++ + E E E E Q E + + +G +
Sbjct: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQ 2142
Score = 148 bits (374), Expect = 3e-35
Identities = 131/412 (31%), Positives = 194/412 (47%), Gaps = 52/412 (12%)
Query: 761 GEEVEGER-EKEEGERKKEERAGKEEKGEEEG-----DQGEGEEEETEGRGEEKEEGGEV 814
GE +GE E G+ + + + +G E G QG G +E +G G ++ +
Sbjct: 1698 GEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDK- 1756
Query: 815 EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGE--EEGEEGEGEEEGE 872
++ E +G+ +E EG+ E E GE E+E GEG E E G +G G E+
Sbjct: 1757 -DPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQE-GEGISERGETGGQGSGHEDNL 1814
Query: 873 EGEGE--GEEEEGEG---EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE- 926
+GE G+++ G+ EG E E EGE + E EG E E EG+ +E EG+ + E E
Sbjct: 1815 QGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-ESEGVEAPEAEGDAQEAEGEAQPESED 1873
Query: 927 ------EGEGEGEEE---------EGEGEGEDGEGEGEEEEGEWEGEEEEG-EGEGEEEG 970
EGE + E E E + E E E E+E + E E E E EGE+E
Sbjct: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
Query: 971 EGEGEEGEGEGEEEEGEGEG---------EEEEGEEEGEEEGEGEEEGEGEGE-EEEEGE 1020
E EG E + E EE E EG E +E EEE + E E E E E E +E EGE
Sbjct: 1934 ESEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
Query: 1021 VEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079
+ E E E E EGE +E EEE + E +G + + EE +E EG+ Q+T +
Sbjct: 1993 AQPESEDVEAPEAEGEMQEAEEEAQP-ESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
Query: 1080 QDG----EEYKKVSKIKGSVKYGKHKTY-QKKSVTNTQGNGKEQRSKMPVQS 1126
DG E ++ + +G V+ + + + + + V + G+ Q V++
Sbjct: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEA 2103
Score = 141 bits (356), Expect = 3e-33
Identities = 143/522 (27%), Positives = 215/522 (41%), Gaps = 42/522 (8%)
Query: 539 TENDDSDEYE-EMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEE-----VEIPEEKEG 592
+E+ ++ E E E+ EG + + T+ +E ++E E E +E
Sbjct: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
Query: 593 AEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652
A++++G E EV ++E + E E L ++ + + +EG+A+ E + PE
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV--ETQEAEGEAQPESEDVEAPE 2004
Query: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712
G E E Q E + K GE + EGE + E + + DG E +
Sbjct: 2005 AEG-----EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
Query: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG---EEVEGERE 769
E E +E E++E E H E E+ + +E EGE + E EG E EGE +
Sbjct: 2060 AEEEA---QEAEGEVQEAEGEAHPESEDVDA-----QEAEGEAQPESEGVEAPEAEGEAQ 2111
Query: 770 KEEG-ERKKEERAGKEEKGEEEGDQGEGEEE-ETEGRGEEKEEGG---EVEGGEVEEGKG 824
K EG E + E + E E + EGE + E+EG + EG E EG E +E +
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
Query: 825 EREEEEEEGEGEEEEGEGE-EEEG-EGEEEEGEGKGEEEG-------EEGEGEEEG-EEG 874
E + E E E E EGE + E EG E E EGE + E EG EE + E EG E
Sbjct: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231
Query: 875 EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE 934
E EGE + E EGE +GE +G + G+G+ E E E + G +
Sbjct: 2232 EAEGEAQP-ESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
Query: 935 EEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEE 994
G G W+ + E G+ G E + E
Sbjct: 2291 RPGSQTG-PSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESST 2349
Query: 995 GEEEGEEEG-EGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
E+E G E+G EG + +E + G + E G +
Sbjct: 2350 SEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRAD 2391
Score = 92.0 bits (227), Expect = 3e-18
Identities = 82/241 (34%), Positives = 109/241 (45%), Gaps = 16/241 (6%)
Query: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGE 947
E+E E + EE+ E+ E +EE + EE E EGEG +EE E E
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEV---QLEETKEGTEGEGLQEEAVQLEETKTEE 1329
Query: 948 GEEEEGEW--EGEEEEGEGEGEEEGE-GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGE 1004
G +EEG E +E EGEG+ EEE + E EE GEG +EEG E +EG EG +GE
Sbjct: 1330 GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG-PEGGLQGE 1388
Query: 1005 GEEEGEGEGEEEEEGEVEG----EVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
EEG E EEG V G E +G+G E++ +EE R E
Sbjct: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE 1448
Query: 1061 EEEEEEGKYQETGEEENERQDGEEYKK-VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR 1119
E E ET +ERQ G + + + K G+ G+ T + TQG +
Sbjct: 1449 EPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQP----TQGAAERSS 1504
Query: 1120 S 1120
S
Sbjct: 1505 S 1505
Score = 90.1 bits (222), Expect = 1e-17
Identities = 128/520 (24%), Positives = 201/520 (38%), Gaps = 93/520 (17%)
Query: 466 MQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKK 525
+QPE E KEA+ + S VE+L + + E++ + + Q Q +
Sbjct: 1899 VQPESEGAEAPEAEKEAQPETES-VEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPE 1957
Query: 526 QQTI-GELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEV 584
+ I + ++ A E++D + E E +E + Q S+ + + ++ + E
Sbjct: 1958 SEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQ---EAEE 2014
Query: 585 EIPEEKEGAE-DSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKS 643
E E +G E K G E QEVE G +KTE + +D E E +
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVE----------GETQKTEGDAQPESDGVEAPEAE--- 2061
Query: 644 VGEAEDGPEGRGDGTCEEGSSGAEHWQ-DEEREKGEKDKGRGEMERP-GEGEKELAEKEE 701
E+ E G+ EG + E D + +GE +E P EGE + AE E
Sbjct: 2062 ----EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Query: 702 WKKRDGEEQEQKEREQGHQKERNQEME-EGGEEEHGEGE---EEEGDREEEEEKEGEGKE 757
+ +GE Q + E + + E + E EG E + EGE E EG +E E+E + +
Sbjct: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
Query: 758 EG-EGEEVEGEREKE---------EGERKKEERAGKEEKGEEEGD-QGEG-EEEETEGRG 805
EG E E EGE + E EGE + E + + EEE + EG E E EG
Sbjct: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEA 2237
Query: 806 EEKEEG---GEVEGG-EVEEGKGEREEEEEE----------------------------- 832
+ + EG GE +G +V G G+ EE E
Sbjct: 2238 QPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTG 2297
Query: 833 ---------GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE--------EGEGEEEGEEGE 875
G +++ E + G+ + + G E E E+ E
Sbjct: 2298 PSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPL 2357
Query: 876 GEGEEEEGEGEGEE--EGEGEGEEEEGEGEGEEEGEGEGE 913
G E+G EG + E + G E G +G G+ +
Sbjct: 2358 GSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397
Score = 88.6 bits (218), Expect = 3e-17
Identities = 81/254 (31%), Positives = 113/254 (44%), Gaps = 38/254 (14%)
Query: 740 EEEGDREEEEEKEGEGKEE----GEGEEVEGEREKE--EGERKKEERAGKEEKGEEEGDQ 793
E+E +R+ EE++ E+ EEV+ E KE EGE +EE EE EEG Q
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
EEG ++E + EG+G++EEE + E EE GEG +EEG EE
Sbjct: 1333 ---------------EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEV 1377
Query: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
EG E G +GE EEG + EG EE G G+ E +G+G +E + E
Sbjct: 1378 KEGP--EGGLQGEALEEGLKEEGLPEE------GSVHGQELSEASSPDGKGSQEDDPVQE 1429
Query: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE-------G 966
EE G+ E EG EE E E + E + + E G + G
Sbjct: 1430 EE--AGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMG 1487
Query: 967 EEEGEGEGEEGEGE 980
+E + + +G E
Sbjct: 1488 QEHTQAQPTQGAAE 1501
Score = 81.3 bits (199), Expect = 5e-15
Identities = 76/245 (31%), Positives = 106/245 (43%), Gaps = 24/245 (9%)
Query: 821 EGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE 880
E + ER+ EE+ E+ + E + EE +EG EGEG +E E +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEE-----TKEGTEGEGLQEEAVQLEETKT 1327
Query: 881 EEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGE 940
EEG +EEG E +E EGEG++E E + EE E G EG + EG EE EG
Sbjct: 1328 EEGL---QEEGVQLEETKETEGEGQQEEEAQLEEIEETG---GEGLQEEGVQLEEVKEGP 1381
Query: 941 GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGE------GEEEEGEGEGEEE- 993
+GE EE + EG EEG G+E E +G+G EEE G E
Sbjct: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEP 1441
Query: 994 ---EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEG 1050
EG EE E E + E + G ++E + G G+E + + +G
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSG---SQLEPGLEKPPGATMMGQEHTQAQPTQG 1498
Query: 1051 EGEEN 1055
E +
Sbjct: 1499 AAERS 1503
Score = 77.4 bits (189), Expect = 7e-14
Identities = 80/243 (32%), Positives = 106/243 (43%), Gaps = 17/243 (6%)
Query: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREE----EEEKE 752
A E+ +RD EEQ + Q N EE EE EG E EG +EE EE K
Sbjct: 1270 ATNEDEAERDSEEQRASSNLE--QLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKT 1327
Query: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE--E 810
EG +E EG ++E E ++ EGE ++EE A EE EE G GEG +EE E KE E
Sbjct: 1328 EEGLQE-EGVQLE-ETKETEGEGQQEEEAQLEEI-EETG--GEGLQEEGVQLEEVKEGPE 1382
Query: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEE 870
GG ++G +EEG E EE +E E +G+G +E+ +E E G
Sbjct: 1383 GG-LQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDP---VQEEEAGRASAS 1438
Query: 871 GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG 930
E EG EE E E G E G + G+ + + +G
Sbjct: 1439 AEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQG 1498
Query: 931 EGE 933
E
Sbjct: 1499 AAE 1501
Score = 74.3 bits (181), Expect = 6e-13
Identities = 74/216 (34%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 798 EEETEGRGEEKEEGGEVE----GGEVEEGKGEREEEEEEGEGEEEEG---------EGEE 844
E+E E EE+ +E EE + E +E EGEG +EE EG +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 845 EEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEG 904
EEG EE E +GE + EE EE EE GEG +EEG + E EG E +GE
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGV---QLEEVKEGPEGGLQGEA 1389
Query: 905 EEEG-EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963
EEG + EG EEG G+E E +G+G ED + EEE G E
Sbjct: 1390 LEEGLKEEGLPEEGSVHGQE-----LSEASSPDGKGSQEDDPVQ-EEEAGRASASAEPCP 1443
Query: 964 GEG-EEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998
EG EE E E + E + + E G E+
Sbjct: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEK 1479
Score = 62.0 bits (149), Expect = 3e-09
Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 9/240 (3%)
Query: 641 AKSVGEAE-DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699
A + EAE D E R E+ + + + E E +G G E + E+ +
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEE--TKT 1327
Query: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759
EE + +G + E+ + +G ++ + E EE GEG +EEG + EE ++ EG +G
Sbjct: 1328 EEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQG 1387
Query: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
E E E KEEG +E +E E G+G +E+ +E+E G E
Sbjct: 1388 EALE---EGLKEEG-LPEEGSVHGQELSEASSPDGKGSQEDDP--VQEEEAGRASASAEP 1441
Query: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
+G E E E + E + + E G K G+ + + +G E
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAE 1501
Score = 56.2 bits (134), Expect = 2e-07
Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 15/232 (6%)
Query: 619 RKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--REK 676
R + + S +L AE + + + E ++G EG G +E + E + EE +E+
Sbjct: 1278 RDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEG---LQEEAVQLEETKTEEGLQEE 1334
Query: 677 GEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK-----EREQGHQKERNQEMEEGG 731
G + + E E G+ E+E A+ EE ++ GE +++ E ++G + E E G
Sbjct: 1335 GVQLEETKETEGEGQQEEE-AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEG 1393
Query: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
+E EG EEG +E E +G+G + + ++EE R +G EE
Sbjct: 1394 LKE--EGLPEEGSVHGQELSEA-SSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
Query: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
+ ET+ E++ G ++E G +E+ G +E + + +G E
Sbjct: 1451 TEPPSHLSETDPSASERQSGSQLEPG-LEKPPGATMMGQEHTQAQPTQGAAE 1501
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/248 (22%), Positives = 94/248 (37%), Gaps = 49/248 (19%)
Query: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
++Q+ + +L ++T E + EE E EG+ ++ Q + T E
Sbjct: 1281 EEQRASSNLEQLAENTVQEEV----QLEETKEGTEGEGLQEEAVQ----LEETKTEEGLQ 1332
Query: 581 DEEVEIPEEKEGA--------------EDSKGNGIEEQEVEANEENVKVHGGRKEKTEIL 626
+E V++ E KE E++ G G++E+ V+ E GG + E L
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL--QGEAL 1390
Query: 627 SDDLTDKAEVSEGK--AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684
+ L ++ EG + + EA P+G+G E+ E++ GR
Sbjct: 1391 EEGLKEEGLPEEGSVHGQELSEA-SSPDGKG--------------SQEDDPVQEEEAGRA 1435
Query: 685 EMER---PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGE---EEHGEG 738
P EG +E E + ER+ G Q E E G +EH +
Sbjct: 1436 SASAEPCPAEGTEEPTEPPSHLSE--TDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
Query: 739 EEEEGDRE 746
+ +G E
Sbjct: 1494 QPTQGAAE 1501
Score = 38.5 bits (88), Expect = 0.037
Identities = 45/190 (23%), Positives = 59/190 (31%), Gaps = 12/190 (6%)
Query: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
G + GG +EG + G +G G E K G
Sbjct: 874 GSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGG 933
Query: 865 GEGEEEGE--------EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE 916
+G+EE E E EE E E G G G E +
Sbjct: 934 PQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVD 993
Query: 917 GEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEE 976
G++ EG GE + G+ E G+ E EG G + G GE +G E
Sbjct: 994 ---PGDDHSLEGLGE-PAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPE 1049
Query: 977 GEGEGEEEEG 986
G E E G
Sbjct: 1050 GVSEAPAEAG 1059
Score = 37.7 bits (86), Expect = 0.063
Identities = 49/197 (24%), Positives = 63/197 (31%), Gaps = 15/197 (7%)
Query: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
G G + G G +E G G G +G G E K
Sbjct: 871 GSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNS---GASRRSSASQGAGSRGLSEEKT 927
Query: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE--EEEGEGEGEEEGEGEGEEGEG 979
G +G+ EE G E EW EE E E G G G
Sbjct: 928 LRSGGGPQGQ-EEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGG 986
Query: 980 EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEG--EVEGEEGEG----- 1032
E G+ EG E + G+ EG+ + E EG + G + + GEG
Sbjct: 987 LRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGA 1046
Query: 1033 --EGEEEEGEEEGEERE 1047
EG E E G +RE
Sbjct: 1047 APEGVSEAPAEAGADRE 1063
Score = 35.0 bits (79), Expect = 0.41
Identities = 36/167 (21%), Positives = 50/167 (29%), Gaps = 8/167 (4%)
Query: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGE--GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
G E + G EG E E E+G G + G GE+
Sbjct: 444 GRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDP 503
Query: 916 ----EGEGKG-EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
+G G G E+G EEG E EW G + G+ E
Sbjct: 504 GLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAE- 562
Query: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017
+ E EG + + E +G+G E+ G E
Sbjct: 563 TSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTRE 609
Score = 33.9 bits (76), Expect = 0.92
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 9/88 (10%)
Query: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE-GEEEEGEG----KGEEEGEEG 865
GG + G EV+ G ++ EG GE + + EG+ G++ E EG + + G
Sbjct: 984 GGGLRGPEVDPG----DDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSG 1039
Query: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEG 893
EG +G EG E G E G
Sbjct: 1040 EGVPQGAAPEGVSEAPAEAGADREAPAG 1067
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 436
Score = 176 bits (447), Expect = 9e-44
Identities = 141/432 (32%), Positives = 236/432 (54%), Gaps = 55/432 (12%)
Query: 700 EEWKKRDGEEQEQ-------KEREQGHQKERNQEME--------EGG-EEEHGEGEEEEG 743
EE K+++ E QE+ K Q H KE +++E EG E+ G+ E+EG
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66
Query: 744 DREEEE----EKEGEGKE-EGEGEEVEGEREKEEGERKKEERAGKEEKG---EEEGDQGE 795
E+E E+EG+ +E EG+ E EG+ ++EG+ +++E +E++G E+EG E
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 796 GEEEETEGRGEEKEEGGEV--EGGEVEEGKGE-REEE----EEEGEGEEEEGEGEEEEGE 848
E + E G+ +E+ G+V + G+V E +G+ RE+E E+EG+ E+EG+ E+EG+
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 849 GEEEEGEGKGEEEGEEGEGEEE-GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
E+EG+ GE+EG+ GE EE+ GE+ E ++EE GE EE+ ++EE GE EE+
Sbjct: 187 VREQEGQ-MGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR---KQEEQMGEQEEQ 242
Query: 908 GEGEGE----EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963
+ + E +EE K EE+ E E + E+E + + + E EE+ GE E + E E
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 964 GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE-----------GEEEGEGEEEGEGE 1012
+ E+ E E+ E E+EE G+ EE+ E++ +EE GE+E + +
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 1013 GEEEEEGEVEGEVEGEEGEGEGEEE----EGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068
+EE+ + E ++ +E + +EE + E+ GE++E+ GE +E R +EE+ E+ +
Sbjct: 363 KQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE 422
Query: 1069 YQETGEEENERQ 1080
EE Q
Sbjct: 423 QMRKQEEHMGEQ 434
Score = 167 bits (424), Expect = 4e-41
Identities = 128/427 (29%), Positives = 237/427 (55%), Gaps = 26/427 (6%)
Query: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK----EEGEGEEVEGEREKEEGERK 776
KE+N E++E + E E + +E + K K +EG+ E EG+ ++EG+ +
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR 69
Query: 777 KEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE-REEE----EE 831
++E +E++G+ + EG+ E EG+ E+E + G+V E +G+ RE+E E+
Sbjct: 70 EQEGQVREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 127
Query: 832 EGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEG 891
EG+ E+EG+ E+EG+ E+EG+ + E+EG+ E E + E EG+ E+EG+ E
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQ---VREQ 183
Query: 892 EGEGEEEEGEGEGEEEGE-GEGEEEEGEGKGE-EEGEEGEGEGEEEEGEGEGEDGEGEGE 949
EG+ E+EG+ GE+EG+ GE EE+ GE + + ++ EE GE EE+ + E + GE E +
Sbjct: 184 EGQVREQEGQ-MGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 950 EEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG 1009
++ E + +++E + +EE E EE E EE+ + + + E+ E+ GE+E + E+
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 1010 EGEGEEEEEGEVEGEVEGEEGEGEGEEEE-----GEEEGEEREKEGEGEENRRNREEEEE 1064
E E+EE+ + E E+ E G++EE E+ E++E+ + EE +EE+ +
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 1065 EEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPV 1124
++ + EE+ +Q+ + K+ +++ K + QK+ + + +EQ +M
Sbjct: 363 KQEEQVRKQEEQMRKQEEQMRKQEEQMR---KQEEQMGEQKEQMGEQKEQMREQEEQMGE 419
Query: 1125 QSKRLLK 1131
Q +++ K
Sbjct: 420 QKEQMRK 426
Score = 145 bits (366), Expect = 2e-34
Identities = 131/438 (29%), Positives = 231/438 (52%), Gaps = 37/438 (8%)
Query: 620 KEKTEILSDDL----TDKAEVS----EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQD 671
KEK L ++L T+K+E+ E K K + P+ G +EG + Q
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ-EGQVREQEGQVREQEGQV 68
Query: 672 EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG 731
E+E +++ E+ G+ ++ + E + + E++ Q ++G +E+ ++ E
Sbjct: 69 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-- 126
Query: 732 EEEHGEGEEEEGDREEEE----EKEGEGKE-EGEGEEVEGEREKEEGERKKEERAGKEEK 786
+ G+ E+EG E+E E+EG+ +E EG+ E EG+ ++EG+ +++E +E++
Sbjct: 127 --QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 787 G---EEEGDQGE-----GEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838
G E+EG GE GE+EE G EE+ + E + GE EE R++EE+ GE EE+
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQM--RKQEEQMGEQEEQ 242
Query: 839 EGEGEEEEGEGEEE---EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE-GEGE 894
+ EE+ + EE+ + E E+E + E EE+ + + + E+EE GE EE+ E E
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 895 GEEEEGEGEGEEEGEGEGEEEEGEGKGEEE-GEEGEGEGEEEEGEGEGEDGEGEGEEEEG 953
+ E E + E+ E E+EE GK EE+ E+ E E++E + E+ GE EE+
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 954 EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG 1013
+ E + + E + ++ E ++ E ++EE GE +E+ GE++ E+ E EE+ G
Sbjct: 363 KQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQK-EQMREQEEQ---MG 418
Query: 1014 EEEEEGEVEGEVEGEEGE 1031
E++E+ + E GE+ E
Sbjct: 419 EQKEQMRKQEEHMGEQKE 436
Score = 140 bits (353), Expect = 7e-33
Identities = 105/321 (32%), Positives = 179/321 (55%), Gaps = 18/321 (5%)
Query: 818 EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877
E++E E +EE + E E+ E + +E + + E + +EG+ E E + E EG+
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 878 GEEEEGEGEGEEEG---EGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE 934
E+EG+ E+EG E EG+ E EG+ E+ EG+ E+EG+ + E+EG+ E EG+
Sbjct: 68 VREQEGQVR-EQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVR-EQEGQVREQEGQV 124
Query: 935 EEGEGEGEDGEGEGEEEEG---EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991
E EG+ + EG+ E+EG E EG+ E EG+ E+ EG+ E EG+ E EG+
Sbjct: 125 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ---EGQVREQEGQVREQEGQVR 181
Query: 992 EEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGE 1051
E+EG+ +E GE+EG+ +EE+ GE E +++ +E E GE+E E+ ++ E+ GE
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE-EQMGEQE--EQMRKQEEQMGE 238
Query: 1052 GEENRRNREEE---EEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSV 1108
EE + +EE+ +EE+ + QE E E Q E+ +++ K K + + Q++ +
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQM 298
Query: 1109 TNTQGNGKEQRSKMPVQSKRL 1129
+ +EQ +M Q +++
Sbjct: 299 REQEEQMREQEEQMREQEEQM 319
Score = 139 bits (349), Expect = 2e-32
Identities = 129/458 (28%), Positives = 233/458 (50%), Gaps = 37/458 (8%)
Query: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
P T E ++ E+ EE + E E+ E++ + + +K RK +T+ +
Sbjct: 2 PRITNEELKEKNAELQEELQLVET------EKSEIQLHIKELK----RKLETDKIPLPQE 51
Query: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE 691
+ EG+ + ++G +G E + + RE+ + + + R E
Sbjct: 52 GQVREQEGQVRE----QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 107
Query: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG-EEEHGEGEEEEGDREEEE- 749
G+ ++E + R+ E Q +++ Q ++E +EG E+ G+ E+EG E+E
Sbjct: 108 GQ---VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164
Query: 750 ---EKEGEGKE-EGEGEEVEGEREKEEGERKKEE-RAGKEEKGEEEGDQGEGEEEETEGR 804
E+EG+ +E EG+ E EG+ ++EG+ ++E + G++E E+ G+Q E +++ E
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQE--EQMGEQEEQMQKQEEQM 222
Query: 805 GEEKEE--GGEVEGGEVEEGKGEREE-----EEEEGEGEEEEGEGEEEEGEGEEEEGEGK 857
GE++E+ E + GE EE ++EE EE+ + EE+ E EE+ E EE+ + K
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
+ E EE GE+E + E E + E E + E+ E E+EE G+ +EE E +E+
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK-QEEQMWEQKEQMW 341
Query: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
E K E+ ++ E GE+EE + E+ + EE+ + E + + E + ++ E GE+
Sbjct: 342 EQK-EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400
Query: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015
E GE++E E EE+ GE+ +E+ +EE GE +E
Sbjct: 401 EQMGEQKEQMREQEEQMGEQ--KEQMRKQEEHMGEQKE 436
Score = 125 bits (314), Expect = 2e-28
Identities = 101/305 (33%), Positives = 163/305 (53%), Gaps = 32/305 (10%)
Query: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
E +E+ E +EE E E+ E + E K + E ++ +EG+ E EG+ E EG+
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 887 GEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946
E+ EG+ E EG+ E+ EG+ E+EG+ + E+EG+ E EG+ E EG+ + EG
Sbjct: 68 VREQ---EGQVREQEGQVREQ-EGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEG 122
Query: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
+ E+EG+ E EG+ E+ EG+ E EG+ E EG+ E+EG+ +E E
Sbjct: 123 QVREQEGQ----VREQEGQVREQ---EGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175
Query: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
+EG+ E+EG+V E EG+ GE EG+ GE+ E+ GE EE + +EE+ E
Sbjct: 176 QEGQ---VREQEGQVR-EQEGQMGEQEGQM------GEQEEQMGEQEEQMQKQEEQMGE- 224
Query: 1067 GKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQS 1126
QE + E Q GE+ ++V K + V+ Q++ + + +EQ +M Q
Sbjct: 225 ---QEEQMRKQEEQMGEQEEQVQKQEEQVQ------KQEEQMRKQEEQMREQEEQMREQE 275
Query: 1127 KRLLK 1131
+++LK
Sbjct: 276 EQMLK 280
Score = 74.3 bits (181), Expect = 6e-13
Identities = 56/265 (21%), Positives = 125/265 (47%), Gaps = 30/265 (11%)
Query: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI 567
+ E+ + Q QK+++ +GE ++ + + E EE + +E + KQ
Sbjct: 201 MGEQEEQMGEQEEQMQKQEEQMGE-QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK 259
Query: 568 FMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS 627
Q E ++E ++ ++KE E + G +E+++ EE ++
Sbjct: 260 QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ----------E 309
Query: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME 687
+ + ++ E + + +G+ E+ + W+ +E+ +K++ + E
Sbjct: 310 EQMREQEEQMREQEEQMGKQEE-----------------QMWEQKEQMWEQKEQMWKQEE 352
Query: 688 RPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG-GEEEHGEGEEEEGDRE 746
+ GE E+++ ++EE ++ E+ ++E + Q+E+ ++ EE GE++ GE++E RE
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 747 EEEEKEGEGKEEGEGEEVEGEREKE 771
+EE+ GE KE+ +E +KE
Sbjct: 413 QEEQM-GEQKEQMRKQEEHMGEQKE 436
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 162 bits (409), Expect = 2e-39
Identities = 112/361 (31%), Positives = 186/361 (51%), Gaps = 24/361 (6%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
++CG HS + + ++Y G N GQLG + +KP + AL + + ACG +H+
Sbjct: 39 VACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREG--NKPEQIGALADQHIIHVACGESHS 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
L ++ G +++ G ++GQLGL TE+ + ++ I Q+S G+ AL DG
Sbjct: 97 LALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADG 156
Query: 160 RLFMWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ F WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G ++ +G
Sbjct: 157 QFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGM 216
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQL 274
G+LGL ++ + +P V + +KV+ ++CG EHT VLT++ V+TFG G GQL
Sbjct: 217 NNAGQLGLSDEK--DRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274
Query: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG--- 330
G + E + +V+E + ++ I+CG HT A + GL+Y FG G G+LG G
Sbjct: 275 GHDSMNDEVNPRRVLE-LMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTC 333
Query: 331 -------LENFTNHFIPTLCSNFLRF---IVKLVACGGCHMVVFAAPHRGVAKEIEFDEI 380
++ + L + RF IVK + GG V + + + ++F +
Sbjct: 334 NVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTM 393
Query: 381 N 381
N
Sbjct: 394 N 394
Score = 150 bits (380), Expect = 5e-36
Identities = 102/313 (32%), Positives = 158/313 (50%), Gaps = 19/313 (6%)
Query: 64 WGQLGLGS-------KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
WG LG + +++P + VK ACG NH++ E G VY G N +
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG E N I +H I ++ G + S AL++ G+LF WG S+GQ+GL
Sbjct: 64 GQLG--HEREGNKPEQIGALADQHII-HVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 177 VSN-VCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ V VP+ Q + + +SCG +H + DG+ + +G+ +G+LGL + +
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF-PSQA 179
Query: 234 TPQLVSEIPE-KVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIEN 291
+PQ V + + QVA GG H+ L+ AV+ +G+ GQLGL + P ++
Sbjct: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEK-DRESPCHVKL 238
Query: 292 IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIV 351
+R Q + YISCGE HTA++T G ++TFG G G+ LG ++ + P + V
Sbjct: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ--LGHDSMNDEVNPRRVLELMGSEV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H + F
Sbjct: 297 TQIACGRQHTLAF 309
Score = 126 bits (317), Expect = 1e-28
Identities = 78/246 (31%), Positives = 129/246 (52%), Gaps = 8/246 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGR 96
+H++CG+ HS ++ +L+ +G+ + GQLGL ++ +++ P ++ L + + +CG
Sbjct: 87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 146
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
H L G + G N+ GQLGLG + Q++AG S AL+
Sbjct: 147 WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALS 206
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVF 214
G +F WG N+ GQ+GL + + P V + + V +ISCG H+A +T G ++ F
Sbjct: 207 LSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTF 266
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTV--VLTENAVYTFGLGQF 271
G G+LG + + + P+ V E+ +V Q+ACG +HT+ V + +Y FG G
Sbjct: 267 GAGSCGQLG--HDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAR 324
Query: 272 GQLGLG 277
GQLG G
Sbjct: 325 GQLGTG 330
Score = 102 bits (253), Expect = 3e-21
Identities = 65/205 (31%), Positives = 103/205 (50%), Gaps = 9/205 (4%)
Query: 161 LFMWGDNSEGQIGLK-NVSNVCVPQQVT---IGKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ WG S GQ G+ N+ + QV + V ++CG HS F+ DGE+Y G
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQLG 275
G+LG + ++ Q+ + + +I VACG H++ L++ ++++G G GQLG
Sbjct: 61 NTKGQLGHERE---GNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
Query: 276 LGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFT 335
L T + P++I+ + QTI +SCG H + G +T+G HG+LGLG E F
Sbjct: 118 LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKE-FP 176
Query: 336 NHFIPTLCSNFLRFIVKLVACGGCH 360
+ P + + VA GG H
Sbjct: 177 SQASPQRVRSLEGIPLAQVAAGGAH 201
Score = 81.3 bits (199), Expect = 5e-15
Identities = 56/188 (29%), Positives = 88/188 (46%), Gaps = 15/188 (7%)
Query: 12 GAVFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFG 60
G FT+GK+ + GK + P ++ G HS ++ + ++ +G
Sbjct: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
NN GQLGL + P VK L+ +KV +CG HT V T+ G V+ G + GQLG
Sbjct: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 275
Query: 121 LGD-TEERNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNVS 178
+E N V+ SE + Q++ G +T A + G ++ +G + GQ+G +
Sbjct: 276 HDSMNDEVNPRRVLELMGSE--VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTC 333
Query: 179 NVCVPQQV 186
NV P V
Sbjct: 334 NVKCPSPV 341
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 160 bits (404), Expect = 8e-39
Identities = 176/621 (28%), Positives = 295/621 (47%), Gaps = 64/621 (10%)
Query: 490 VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE 549
+E L + D L++ + +NE+ K + EL + L E++ S+
Sbjct: 161 IEELTKERDALSLELYRNTITNEELKKKN-----------AELQEKLRLAESEKSEIQLN 209
Query: 550 MSEMKE----GKACKQHVSQGIFMTQPATTIEAFSDEEVEI--PEEKEGAEDSKGNGIEE 603
+ E+K K V + E ++E +I EEK ++ + + E
Sbjct: 210 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER---LRE 266
Query: 604 QEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGS 663
QE + E+ K+ K E + + E+ E K + E E+ + + +
Sbjct: 267 QEGKMREQEEKMRRQEKRLREQEKELREQEKELRE--QKKLREQEEQMQEQEE------- 317
Query: 664 SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE-----------EQEQ 712
+ W+ EE+ + +++K + ER E EK++ E+E+ K RD E E+E+
Sbjct: 318 ---KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ-KMRDQEERMWEQDERLREKEE 373
Query: 713 KEREQ---GHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGERE 769
+ REQ Q+E+ QE E E E EEEE RE+EE+ + + + E EE E +++
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 770 K-EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE 828
+ E + K E+ +E+ E+ +Q E ++ E G+EK+ + + E E+ E+EE
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 493
Query: 829 ---EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
++E+ ++EE E++E E+EE + E+ + + EE+ E + E+E+
Sbjct: 494 KMRDQEQKMWDQEERMWEQDERLREKEE---RMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Query: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
+ EE+ E E E + EE E E+EE + EE+ E E + E+E E E E
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE-EKMQEQEE 609
Query: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEE---EEGEGEGEEEEGEEEGEEE 1002
E+EE WE +EEE + + +EE E EE E EE E+ E E+EE E EE+
Sbjct: 610 KMWEQEEKMWE-QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668
Query: 1003 GEGEEEGEGEGEEEEEGEVEGEVEGEEG-EGEGEEEEGEEE---GEEREKEGEGEENRRN 1058
+G+EE E EE+ +G+ E E EE G+ E+ G+EE G+E + G+ EE R
Sbjct: 669 MQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ-EEMREK 727
Query: 1059 REEEEEEEGKYQETGEEENER 1079
E +++ K QE E ER
Sbjct: 728 EERIRDQKEKMQERLPEHEER 748
Score = 145 bits (366), Expect = 2e-34
Identities = 151/579 (26%), Positives = 283/579 (48%), Gaps = 52/579 (8%)
Query: 575 TIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKE------KTEILSD 628
T E + E+ E+ AE E+ E++ N + +K R + +T L +
Sbjct: 181 TNEELKKKNAELQEKLRLAES------EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQE 234
Query: 629 DLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMER 688
++ + E + K + + E+ + + E+ E EE+ + ++ + R + +
Sbjct: 235 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ---EEKMRRQEKRLREQEKE 291
Query: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748
E EKEL E+++ ++++ + QEQ+E+ +++ ++ E+ +E E+E+ RE+E
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351
Query: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE-----EGDQGEGEEEETEG 803
++ + EE E+ E REKEE R++E+ +EEK +E E ++ EEEET
Sbjct: 352 QKMRDQ--EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 804 RGEEKEEGGEVEGGEVEE---------------GKGEREEEEEEGEGEEEEGEGEEEEGE 848
EEK + E E EE + E+ +E+EE E+EE ++EE
Sbjct: 410 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 469
Query: 849 GEEEE---GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGE 905
G+E++ E E+E + E EE+ + E + ++E ++E E EE E +
Sbjct: 470 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKM 529
Query: 906 EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE 965
+ E + EE+ + E++ + E + EEE E E E EE E E + +E E +
Sbjct: 530 WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 589
Query: 966 GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEV 1025
E+ E E+ E E+EE E EE+ E+E E++ + +EE E EE+ + E
Sbjct: 590 MREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ-----EQ 644
Query: 1026 EGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE- 1084
E + E E + E EE+ E+E++ +G+E + RE+EE+ +G+ ++ E+E + + EE
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKM-REQEEKMQGQEEKMREQEEKMRGQEEK 703
Query: 1085 -YKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKM 1122
+ + K+ G + K + ++ + + ++Q+ KM
Sbjct: 704 MWGQEEKMWGQ----EEKMWGQEEMREKEERIRDQKEKM 738
Score = 134 bits (338), Expect = 4e-31
Identities = 134/463 (28%), Positives = 231/463 (49%), Gaps = 27/463 (5%)
Query: 691 EGEKELAEKEE--WKKRDG-EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEE--EGDR 745
E EK++ ++EE W++ + EQE K REQ + R ++ E+E E E+E E +
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304
Query: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRG 805
E+E++ + +EE E+ E RE+EE ++EER ++EK E +Q ++EE
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364
Query: 806 EEKEEGGEVEGGEVEE-GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
+E+ E E E+ + E + +EEE E E+ EEEE E+EE K EE E
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE----------GEE 914
E +E ++ E +E+ E E +E E + E+E + +EE G+ E+
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 915 EEGEGKGEEEGEEGEGE-GEEEEGEGEGEDGEGEGEEEEGE----WEGEEEEGEGEGEEE 969
E+ + EE+ + E + ++EE E ++ E EE E W+ EE+ E + +E
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEE---GEEEGEGEEEGEGEGEEEEEGEVEGEVE 1026
E + + E + EEE E E++ EEE E+E + +E+ E E+EE+ + E
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM 604
Query: 1027 GEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYK 1086
E+ E E+EE E EE +K E EE +EE+ +E+ + EE+ Q+ + +
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE 664
Query: 1087 KVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRL 1129
+ K++G + + Q++ + + +EQ KM Q +++
Sbjct: 665 QEEKMQGQEEKMRE---QEEKMQGQEEKMREQEEKMRGQEEKM 704
Score = 122 bits (307), Expect = 1e-27
Identities = 132/497 (26%), Positives = 242/497 (48%), Gaps = 44/497 (8%)
Query: 581 DEEVEIPE-EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEG 639
++E E+ E EKE E K + EQE + E+ K+ ++EK + + + E
Sbjct: 287 EQEKELREQEKELREQKK---LREQEEQMQEQEEKMWE-QEEKMREQEEKMWRQEERLWE 342
Query: 640 KAKSVGEAEDGPEGRGDGTCEEGSS--GAEHWQDEEREKGEKDKGRGEMERPGEGEKELA 697
+ K + E E + + E+ E E+ + E+++ E ER E EK++
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR 402
Query: 698 EKEEWKKRDGEEQEQKER------EQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
E+EE + E+ +++E E+ Q++R E +E E+ E+EE E+EE+
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 752 EGEGKEEGEGEEVEGEREK---EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEK 808
+ EE+ G+ +K +E R++E++ ++E+ + +Q ++EE +E+
Sbjct: 463 RDQ-------EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDER 515
Query: 809 EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868
E EE E+++ ++ E EE + +E+E + ++E + + EE E E +
Sbjct: 516 LR-------EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 869 EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG 928
EE +EE+ + + E+ E E + E E + +E+ E E+EE + EEE
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE---- 624
Query: 929 EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988
+ +E+ E E E E+EE WE EE+ E +EE E EE + +G+EE
Sbjct: 625 --DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE---QEEKMREQEE-KMQGQEE---- 674
Query: 989 EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048
+ E+E + +G+EE E+E + G+EE+ E ++ G+E + G+EE E+E R++
Sbjct: 675 KMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQ 734
Query: 1049 EGEGEENRRNREEEEEE 1065
+ + +E EE E
Sbjct: 735 KEKMQERLPEHEERCSE 751
Score = 118 bits (295), Expect = 4e-26
Identities = 154/606 (25%), Positives = 271/606 (44%), Gaps = 66/606 (10%)
Query: 560 KQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGR 619
K+ ++ G T P TT + E PE+++ A + +E+EA + +++ +
Sbjct: 49 KKKINNG---TNPETT----TSEGCHSPEDEKKASHQHQEALR-REIEAQDHTIRILTCQ 100
Query: 620 KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGD------GTCEEGSSGAEHWQDE- 672
K + E D A E ++GE++D GR G + S W +
Sbjct: 101 KTELETALYYSQDAARKFEDG--NLGESKD-LAGRLHHSWHFAGELQRALSAVSTWHKKA 157
Query: 673 EREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQE-------QKEREQGHQKERNQ 725
+R E K R + E + EE KK++ E QE +K Q + KE +
Sbjct: 158 DRYIEELTKERDALSL--ELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR 215
Query: 726 EMEEGG---EEEHGEGEEEEGDREEEEEKEGEGK----EEGEGEEVEGEREKEEGERKKE 778
++E + +EE R+EEE +E E K EE + E RE+E R++E
Sbjct: 216 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE 275
Query: 779 ERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838
E+ ++EK E+E E R +EKE + E K RE+EE+ E EE+
Sbjct: 276 EKMRRQEK--------RLREQEKELREQEKE---------LREQKKLREQEEQMQEQEEK 318
Query: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
E EE+ E EE+ +E E E++ E E + ++E ++E E EE
Sbjct: 319 MWEQEEKMREQEEK----MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 374
Query: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
E E E E + +EEE + E++ E E E+E + + ++ E E+EE EW+ +
Sbjct: 375 MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE-ENMWEQEEKEWQQQ 433
Query: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE---GEEEGEGEEEGEGEGEE 1015
+ E E E E+ E E+EE + EE G+E+ +E+ +E+ E EE
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 493
Query: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075
+ + + + EE E +E E+E RE++ ++ + REE++ +E + + +E
Sbjct: 494 KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE 553
Query: 1076 ENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPS 1135
E R++ ++ K++ + + Q++ + + +EQ KM Q +++ +
Sbjct: 554 EKMREEERMREREKKMREEEEMMRE---QEEKMQEQEEKMREQEEKMWEQEEKMQEQ--- 607
Query: 1136 GSKKFW 1141
+K W
Sbjct: 608 -EEKMW 612
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 154 bits (390), Expect = 4e-37
Identities = 102/299 (34%), Positives = 161/299 (53%), Gaps = 15/299 (5%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
+ CG H+ V + +Y G N+ GQLG + + KP V AL + + +CG HT
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHT 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEE--RNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
L + G VYA G +++GQLGL +EE R ++ S S+ +I Q++ G S AL++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSK 154
Query: 158 DGRLFMWGDNSEGQIGL-KNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVF 214
+F WG N GQ+GL + PQ + +G P ++ G HS +T G ++ +
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
G + G+LGL ++ + P L+ + +K++ + CG +HT LT E V+TFG G +G
Sbjct: 215 GRNKFGQLGLNDE--NDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 273 QLGLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG 330
QLG + E + KV E + ++ I+CG HT A + G +Y+FG G +G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Score = 151 bits (382), Expect = 3e-36
Identities = 102/313 (32%), Positives = 164/313 (52%), Gaps = 14/313 (4%)
Query: 59 FGSNNWGQLGLGS--KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
+G+ ++GQLGLG + + +P ++V+ CG HT+ + G VY G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG + + V++ I +S G + AL + G+++ WG +S+GQ+GL
Sbjct: 64 GQLG-HEKSRKKPEQVVAL--DAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 177 VSN-VCVPQQVTIGKPVS--WISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ VP+ + + ++CGYYHS ++ E++ +G+ + G+LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENI 292
L S + +QVA GG H+ VLT A++ +G +FGQLGL + P +++++
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN-DRYVPNLLKSL 239
Query: 293 RDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI-PTLCSNFLRFIV 351
R Q I YI CGE+HTA +T G ++TFG G +G+LG N T+H I P + IV
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG---HNSTSHEINPRKVFELMGSIV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H F
Sbjct: 297 TEIACGRQHTSAF 309
Score = 130 bits (327), Expect = 7e-30
Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 16/283 (5%)
Query: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVHL--------SCGDEHSAVVTGNNKLYMFGS 61
D G V+T G + + K K + V L SCG+ H+ + ++Y +G
Sbjct: 51 DDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 62 NNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
++ GQLGL GS+ I P +K+L ++ ACG H+L ++ V+ G N GQLG
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LG ++ T + Q++AG S LT G +F WG N GQ+GL + ++
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 181 CVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV 238
VP + + + +I CG H+A +T +G ++ FG G+LG + + P+ V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG--HNSTSHEINPRKV 288
Query: 239 SEIPEKVI-QVACGGEHT--VVLTENAVYTFGLGQFGQLGLGT 278
E+ ++ ++ACG +HT V + +Y+FGLG GQLG G+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331
Score = 79.3 bits (194), Expect = 2e-14
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 21/182 (11%)
Query: 14 VFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFGSN 62
VF +G++K+ + G K P + ++ G HS V+T + ++ +G N
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 217
Query: 63 NWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLG 122
+GQLGL ++ P +K+L+ +K+ CG +HT T+ G V+ G GQLG
Sbjct: 218 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 123 DTEE----RNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNV 177
T R F ++ +E ++ G +TSA + GR++ +G GQ+G +
Sbjct: 278 STSHEINPRKVFELMGSIVTE-----IACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 178 SN 179
SN
Sbjct: 333 SN 334
Score = 69.3 bits (168), Expect = 2e-11
Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 11 SGAVFTFGKSKFAE---NNPGKFWFKNDVP-------VHLSCGDEHSAVVTGNNKLYMFG 60
SGA+F +G++KF + N+ + N + V++ CG++H+A +T ++ FG
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST-EGGNVYATGGNNEGQL 119
+ +GQLG S S P V L V ACGR HT G +Y+ G GQL
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327
Query: 120 GLGDTEERNT 129
G G T R +
Sbjct: 328 GTGSTSNRKS 337
Score = 44.7 bits (104), Expect = 5e-04
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 12 GAVFTFGKSKFA---------ENNPGK-FWFKNDVPVHLSCGDEH-SAVVTGNNKLYMFG 60
G VFTFG + E NP K F + ++CG +H SA V + ++Y FG
Sbjct: 261 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 61 SNNWGQLGLGSKSAISKPTCVK 82
GQLG GS S P VK
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVK 342
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 154 bits (390), Expect = 4e-37
Identities = 102/299 (34%), Positives = 161/299 (53%), Gaps = 15/299 (5%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
+ CG H+ V + +Y G N+ GQLG + + KP V AL + + +CG HT
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEAHT 96
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEE--RNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
L + G VYA G +++GQLGL +EE R ++ S S+ +I Q++ G S AL++
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL--SDIQIVQVACGYYHSLALSK 154
Query: 158 DGRLFMWGDNSEGQIGL-KNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVF 214
+F WG N GQ+GL + PQ + +G P ++ G HS +T G ++ +
Sbjct: 155 ASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGW 214
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
G + G+LGL ++ + P L+ + +K++ + CG +HT LT E V+TFG G +G
Sbjct: 215 GRNKFGQLGLNDE--NDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYG 272
Query: 273 QLGLGTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGRHGKLGLG 330
QLG + E + KV E + ++ I+CG HT A + G +Y+FG G +G+LG G
Sbjct: 273 QLGHNSTSHEINPRKVFE-LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTG 330
Score = 151 bits (382), Expect = 3e-36
Identities = 102/313 (32%), Positives = 164/313 (52%), Gaps = 14/313 (4%)
Query: 59 FGSNNWGQLGLGS--KSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNE 116
+G+ ++GQLGLG + + +P ++V+ CG HT+ + G VY G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
GQLG + + V++ I +S G + AL + G+++ WG +S+GQ+GL
Sbjct: 64 GQLG-HEKSRKKPEQVVAL--DAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 177 VSN-VCVPQQVTIGKPVS--WISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHR 233
+ VP+ + + ++CGYYHS ++ E++ +G+ + G+LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENI 292
L S + +QVA GG H+ VLT A++ +G +FGQLGL + P +++++
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN-DRYVPNLLKSL 239
Query: 293 RDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFI-PTLCSNFLRFIV 351
R Q I YI CGE+HTA +T G ++TFG G +G+LG N T+H I P + IV
Sbjct: 240 RSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG---HNSTSHEINPRKVFELMGSIV 296
Query: 352 KLVACGGCHMVVF 364
+ACG H F
Sbjct: 297 TEIACGRQHTSAF 309
Score = 130 bits (327), Expect = 7e-30
Identities = 89/283 (31%), Positives = 143/283 (50%), Gaps = 16/283 (5%)
Query: 10 DSGAVFTFGKSKFAENNPGKFWFKNDVPVHL--------SCGDEHSAVVTGNNKLYMFGS 61
D G V+T G + + K K + V L SCG+ H+ + ++Y +G
Sbjct: 51 DDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 62 NNWGQLGL-GSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
++ GQLGL GS+ I P +K+L ++ ACG H+L ++ V+ G N GQLG
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
LG ++ T + Q++AG S LT G +F WG N GQ+GL + ++
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 181 CVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLV 238
VP + + + +I CG H+A +T +G ++ FG G+LG + + P+ V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG--HNSTSHEINPRKV 288
Query: 239 SEIPEKVI-QVACGGEHT--VVLTENAVYTFGLGQFGQLGLGT 278
E+ ++ ++ACG +HT V + +Y+FGLG GQLG G+
Sbjct: 289 FELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGS 331
Score = 79.3 bits (194), Expect = 2e-14
Identities = 51/182 (28%), Positives = 87/182 (47%), Gaps = 21/182 (11%)
Query: 14 VFTFGKSKFAENNPGKFWFKNDVP-----------VHLSCGDEHSAVVTGNNKLYMFGSN 62
VF +G++K+ + G K P + ++ G HS V+T + ++ +G N
Sbjct: 158 VFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRN 217
Query: 63 NWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLG 122
+GQLGL ++ P +K+L+ +K+ CG +HT T+ G V+ G GQLG
Sbjct: 218 KFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 123 DTEE----RNTFHVISFFTSEHKIKQLSAG-SNTSAALTEDGRLFMWGDNSEGQIGLKNV 177
T R F ++ +E ++ G +TSA + GR++ +G GQ+G +
Sbjct: 278 STSHEINPRKVFELMGSIVTE-----IACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGST 332
Query: 178 SN 179
SN
Sbjct: 333 SN 334
Score = 69.3 bits (168), Expect = 2e-11
Identities = 43/130 (33%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 11 SGAVFTFGKSKFAE---NNPGKFWFKNDVP-------VHLSCGDEHSAVVTGNNKLYMFG 60
SGA+F +G++KF + N+ + N + V++ CG++H+A +T ++ FG
Sbjct: 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFG 267
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVST-EGGNVYATGGNNEGQL 119
+ +GQLG S S P V L V ACGR HT G +Y+ G GQL
Sbjct: 268 AGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQL 327
Query: 120 GLGDTEERNT 129
G G T R +
Sbjct: 328 GTGSTSNRKS 337
Score = 44.7 bits (104), Expect = 5e-04
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 11/82 (13%)
Query: 12 GAVFTFGKSKFA---------ENNPGK-FWFKNDVPVHLSCGDEH-SAVVTGNNKLYMFG 60
G VFTFG + E NP K F + ++CG +H SA V + ++Y FG
Sbjct: 261 GGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 61 SNNWGQLGLGSKSAISKPTCVK 82
GQLG GS S P VK
Sbjct: 321 LGGNGQLGTGSTSNRKSPFTVK 342
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 149 bits (377), Expect = 1e-35
Identities = 113/446 (25%), Positives = 209/446 (46%), Gaps = 23/446 (5%)
Query: 647 AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA-EKEEWKKR 705
+++ P RG G + + G + ++ ++E+ E+ + + + ER + ++E EK+ +KR
Sbjct: 33 SQESPRRRGLGQAHKDADGDDRERNRQKER-ERRREKRQTERETDRKRERRREKDRHRKR 91
Query: 706 DGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE 765
D + Q++RE+ +++ ++E + E+E +E RE E E+EGE G + +
Sbjct: 92 DRHRERQRDREKERERQTDRERDRQREKERNRQKE----RERETEREGE---RGRDRQTD 144
Query: 766 GEREKE---EGERKKEERAGKE-EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE 821
G+RE+E + E+++E + +E ++ E Q E E E+ E+E E E + E+
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE-NKTED 203
Query: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881
ER E E E E E E + E + + K E E E+ E E E E ++
Sbjct: 204 RHSERGRERE--RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE-RDK 260
Query: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
E E E + + + + ++E E + + + + E + + E E E E E
Sbjct: 261 ERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERE 320
Query: 942 EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEE 1001
+ E E E + E+E E + + + E + E G E + E E E E +
Sbjct: 321 RERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQ 380
Query: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREE 1061
EE E + + + + E E + E + +G+ E E+ EREK+ E E R E
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDR---DGQRE--TEKQREREKDRESERGRERGRE 435
Query: 1062 EEEEEGKYQETGEEENERQDGEEYKK 1087
E+++G+ ++ E + +RQ G + K+
Sbjct: 436 REKQKGRERDR-ERQTDRQAGRQRKR 460
Score = 139 bits (351), Expect = 1e-32
Identities = 110/414 (26%), Positives = 183/414 (44%), Gaps = 17/414 (4%)
Query: 688 RPG--EGEKELAEKEEWKKRDGEEQE---QKEREQGHQKERNQ-EMEEGGEEEHGEGEEE 741
RPG E + + K DG+++E QKERE+ +K + + E + E +
Sbjct: 30 RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHR 89
Query: 742 EGDREEEEEKEGEGKEEGEGE-EVEGEREKEEGERKKEERAGKE--EKGEEEGDQGEGEE 798
+ DR E +++ E + E + + E + +REKE +K+ ER + E+G + G+ E
Sbjct: 90 KRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRER 149
Query: 799 EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858
E +E+E + E E ++E E E+ E E E + E+ E+ +G
Sbjct: 150 ERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERG 209
Query: 859 EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE---EGEGEGEEEGEGEGEEE 915
E E E E E E E + + + E E E + E E E E E ++E E E + +
Sbjct: 210 RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRD 269
Query: 916 EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE---EEEGEGEGEEEGEG 972
+ ++E E + E + E + E E E E + E E E E E E
Sbjct: 270 RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERER 329
Query: 973 EGEEGEGEGEEEEGEGEGEEEEGEEEGEEEG-EGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
+ E +E E + + + E E + G EG + E E E E E + + E EE E
Sbjct: 330 QRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389
Query: 1032 GEGEEEEGEEEGEEREKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
+ + + +E + EK+ +G+ E + RE E++ E + E E+Q G E
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443
Score = 120 bits (301), Expect = 7e-27
Identities = 108/447 (24%), Positives = 193/447 (43%), Gaps = 34/447 (7%)
Query: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE-EKEGEGKEEGEG 761
++R G ++ + R G + +G + E +E E RE+ + E+E + K E
Sbjct: 28 RRRPGSQESPRRRGLGQAHKD----ADGDDRERNRQKERERRREKRQTERETDRKRERRR 83
Query: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG--GEV 819
E+ + ER+++ +E + + E D+ + E+ R +E+E E EG G
Sbjct: 84 EKDRHRKRDRHRERQRDREKERERQTDRERDR---QREKERNRQKERERETEREGERGRD 140
Query: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
+ G+RE E + +E E + + E E + + E E E E + E E +
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200
Query: 880 EEEGEGEGEEEGEGEGE-----EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE 934
E+ E E E E E E + + + E + + + E E + E E E E ++
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 935 EEGEGEGEDGEGEGEEEEGEWEGE-EEEGEGEGEEEGEGEGE-EGEGEGEEEEGEGEGEE 992
E D + + ++E E + + + + E + E E + E + E E E E E
Sbjct: 261 ERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERE 320
Query: 993 EEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE-----GEEGEGEGEEEEGEEEGEERE 1047
E E E E + E E + E E E + + + E + E G EG + E E E +R+
Sbjct: 321 RERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQ 380
Query: 1048 KEGEGEENRRNREEEEEEEGKYQ----ETGEEENERQDGEEYKKVSKIKGSVKYGKHKTY 1103
E EE R+R+ + ++E + Q G+ E E+Q E +K + + + G+ +
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ--REREKDRESERGRERGREREK 438
Query: 1104 QK------KSVTNTQGNGKEQRSKMPV 1124
QK + T+ Q + +RS + V
Sbjct: 439 QKGRERDRERQTDRQAGRQRKRSTLYV 465
Score = 107 bits (267), Expect = 7e-23
Identities = 88/364 (24%), Positives = 162/364 (44%), Gaps = 16/364 (4%)
Query: 589 EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAE 648
EKE + ++E E N + R+ +TE + D+ + + + +AE
Sbjct: 102 EKERERQTDRERDRQREKERNRQKE-----RERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE 708
E + D + + ++ EREK +++ E +R E + E E ++R+ E
Sbjct: 157 KERERQTDRE-RQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER 768
+ + E E+ Q +R ++ + E E + E E E E E++ E + E + + R
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 769 EKE---EGERKKEERAGKEEKGEEEGD-QGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824
+KE + +RK++ R ++ + E + + Q E E E R E+E E E E +
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335
Query: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884
+RE+E E + E + E G E G+ + E E E + E EE E +
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGRE----GRRQAERERERERERDRQSAREREERERD 391
Query: 885 GEGEEEGEGEGE-EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE-GEEEEGEGEGE 942
+ + + E E + E++ +G+ E E + E E++ +G E G E E + G E + E + +
Sbjct: 392 RDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTD 451
Query: 943 DGEG 946
G
Sbjct: 452 RQAG 455
Score = 100 bits (249), Expect = 8e-21
Identities = 92/377 (24%), Positives = 156/377 (41%), Gaps = 47/377 (12%)
Query: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812
G+ ++ +G++ E R+KE ER++E+R Q E E + R EK+
Sbjct: 43 GQAHKDADGDDRERNRQKER-ERRREKR------------QTERETDRKRERRREKDR-- 87
Query: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE 872
K +R E + +E E + + E E+E + ++ E E E EGE
Sbjct: 88 --------HRKRDRHRERQRDREKERERQTDRERDRQREKE---RNRQKERERETEREGE 136
Query: 873 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEG 932
G + + E E + + E E E + + E + + E ++E K +E E E
Sbjct: 137 RGRDRQTDGQRERERQRDAEKE-RERQTDRERQRQTERNRQKEREREKNRQERRERE--- 192
Query: 933 EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE 992
+ E E + ED E G E E E E E E E + + + E E
Sbjct: 193 RQREKENKTEDRHSE--------RGRERERERETETETERKRQT-----DRERDRQRKTE 239
Query: 993 EEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052
E E++ E E E E E + E E E + + + + + E E + + + ER++E E
Sbjct: 240 REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299
Query: 1053 E-ENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNT 1111
+ E +R RE E E K + E E ER E ++ + + + K K +
Sbjct: 300 KRERQRERERERERNRKRERERERERER---ERQRETERDREKERERKRKRQTEMDRERN 356
Query: 1112 QGNGKEQRSKMPVQSKR 1128
+ G+E R + + +R
Sbjct: 357 RQTGREGRRQAERERER 373
Score = 96.7 bits (239), Expect = 1e-19
Identities = 90/359 (25%), Positives = 161/359 (44%), Gaps = 39/359 (10%)
Query: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
+K++++QT E + N + E +EG+ + + G Q + +
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETE--REGERGRDRQTDG----QRERERQRDA 155
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK 640
++E E ++E ++ N +E+E E N + + ++EK D +++ E +
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 641 AKSVGEAE-----DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
++ E E D R T E AE + ERE E+DK R E ER + +++
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERET-ERDKER-ERERDRDRDRD 273
Query: 696 LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG 755
+KE ++ D + Q + ER++ +++R ++ E E E E E +RE E E++ E
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333
Query: 756 KEEGEGEEV-------------------EGEREKE-EGERKKE-ERAGKEEKGEEEGDQG 794
+ + E E EG R+ E E ER++E +R E+ E E D+
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRD 393
Query: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
++E E R EK+ G+ E E + ERE++ E G E E E+++G + E
Sbjct: 394 RDRQKERE-RQTEKDRDGQRE----TEKQREREKDRESERGRERGREREKQKGRERDRE 447
Score = 92.0 bits (227), Expect = 3e-18
Identities = 73/332 (21%), Positives = 144/332 (43%), Gaps = 9/332 (2%)
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK 640
+ E E E E D + +G E+E + + E + +E+ ++ K E
Sbjct: 126 ERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR-QTERNRQKEREREKN 184
Query: 641 AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
+ E E E G E ++ E E + K + + ER + + E E+E
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTE-RERE 243
Query: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE-----EEEGDREEEEEKEGEG 755
+ +R+ + + ER++ ++ER+++ + ++ E + + +R+ E E++ E
Sbjct: 244 KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER 303
Query: 756 KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVE 815
+ E E E + + E ER++E +E + + E ++ + +TE E + G E
Sbjct: 304 QRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGR-E 362
Query: 816 GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE 875
G E + ERE E + E E E E + ++E E + E++ + E+ E E
Sbjct: 363 GRRQAERERERERERDRQSARERE-ERERDRDRDRQKERERQTEKDRDGQRETEKQRERE 421
Query: 876 GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
+ E E G G E + +G E + E + + +
Sbjct: 422 KDRESERGRERGREREKQKGRERDRERQTDRQ 453
Score = 65.5 bits (158), Expect = 3e-10
Identities = 83/386 (21%), Positives = 141/386 (36%), Gaps = 44/386 (11%)
Query: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
+++++QT ++ +N E KE K +H +G + T +
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERET-----E 219
Query: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
E E + + D + E+E +A E ++K + D+ + +
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER---ERERDRDRDRDRRQ 276
Query: 642 KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA---- 697
K D R E E ++ ERE+ K E ER E E++
Sbjct: 277 KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336
Query: 698 ---EKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHG-----EGEEEEGDREEEE 749
E+E +KR E ++ R+ G + R E E E E E EE E DR+ +
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDR 396
Query: 750 EKEGEG--------------KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGE 795
+KE E + E E ++ E ER +E G R++E++ G+E E + D+
Sbjct: 397 QKERERQTEKDRDGQRETEKQRERE-KDRESERGRERG-REREKQKGRERDRERQTDRQA 454
Query: 796 GEEEETE----GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE-GE 850
G + + G V+ +G R + E + + G +
Sbjct: 455 GRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPE---DPKAASTRFPWGRPAK 511
Query: 851 EEEGEGKGEEEGEEGEGEEEGEEGEG 876
G G E GE+ G+ GEG
Sbjct: 512 ASRGRVAGRRRWEPRLGEKRGQGGEG 537
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 149 bits (376), Expect = 1e-35
Identities = 162/590 (27%), Positives = 286/590 (48%), Gaps = 39/590 (6%)
Query: 512 EKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQ 571
E+ K+ +K+ ++Q Q+ L E + E EE + +E K +Q
Sbjct: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ---------- 360
Query: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
+E++ EEK ++ + + EQE + E+ K+ ++E+ + L
Sbjct: 361 ---------EEKMREQEEKMWRQEER---LWEQEKQMREQEQKMRD-QEERMWEQDERLR 407
Query: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE 691
+K E + K + E E + E+ + E EE E++K E E
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467
Query: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE-- 749
++E +K+E + EE+E +++ QKE+ E E+ E+E E+EE R++EE
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 750 -EKEGEGKEEGEGEEVEGEREKEEGERKKEERA-GKEEKGEEEGDQGEGEEEETEGRGEE 807
+++ ++E E+ + E+EE R +E++ +EE+ E++ + E + + E + E
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
Query: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE---EEGEGKGEEEGEE 864
+E E E EE + RE+EE+ E EE+ E EE+ E EE E+ E E+E +
Sbjct: 588 EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647
Query: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-EGEGEEEEGEGKGEE 923
E EE+ E + E++E E E+ E E +E+ E E+E E + +E+E + +E
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQE 707
Query: 924 EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEE 983
+ E E E E+ E E+ E EE+ E E + +E E E E+ E E+ E E+
Sbjct: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 984 EEGEGEGEEE-EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEE--GE 1040
+ + E+ E E+ E+E E+E + +EE+ E ++ G+E + G+EE+ G+
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 1041 EE---GEEREKEGEGEENRRNREEEEEEEGKYQETG-EEENERQDGEEYK 1086
EE G+E + G+ EE +EE+ EE+ + QE E+ E+ G+E K
Sbjct: 828 EEKMWGQEEKMWGQ-EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876
Score = 140 bits (352), Expect = 9e-33
Identities = 188/719 (26%), Positives = 324/719 (45%), Gaps = 105/719 (14%)
Query: 490 VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE 549
+E L + D L++ + +NE+ K + EL + L E++ S+
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKN-----------AELQEKLPLAESEKSEIQLN 247
Query: 550 MSEMKE----GKACKQHVSQGIFMTQPATTIEAFSDEEVEI--PEEKEGAEDSKGNGIEE 603
+ E+K K V + E ++E +I EEK ++ + + E
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER---LRE 304
Query: 604 QEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGS 663
QE + E+ K+ K E + + E+ E K + E E+ + + + E+
Sbjct: 305 QEGKMREQEEKMWRQEKRLREQEKELREQEKELRE--QKELREQEEQMQEQEEKMWEQEE 362
Query: 664 SGAEH-----------WQDEEREKGEKDKGRGEMERPGEGEKELAEKEE--------WKK 704
E W+ E++ + ++ K R + ER E ++ L EKEE W++
Sbjct: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
Query: 705 -------RDGEEQEQKEREQGHQ-------KERNQEMEEGGEEEHGEGEEEEGDREEE-- 748
+ +EQE+K R+Q + +ER ++M E EEE +EE+ ++EE
Sbjct: 423 VEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE--EEETMREQEEKMQKQEENM 480
Query: 749 ---EEKEGEGKEEGEGEEVEGEREK-----------EEGERKKEERAGKEEKGEEEGDQG 794
EEKE + + E +E E+EK EE R +EE G+E+K +
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
Query: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE--- 851
E E++ E EEK E + + EE ++ +E+E+ ++EE EEE E
Sbjct: 541 EQEDQMWE--QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 852 -EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910
EE E E+E + E EE+ +E E + E+E + + +EE E EE+ E E E+ E
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-EKMWEQ 657
Query: 911 EGEEEEGEGKGE-EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969
+ E+ E E E+ +E E E+EE E E E + +E+E + +E+ E E E
Sbjct: 658 QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE 717
Query: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEE 1029
E + E E E+E + + +EE+ +E+ EE E EE + +EE+ E + E +E
Sbjct: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE--KMWEQEEKMWEQQRLPEQKE 775
Query: 1030 GEGEGEE-EEGEEEGEEREKEGEGEENRRNREEE---EEEEGKYQET---GEEE------ 1076
E E+ +E E+ E+ EK + EE R +EE+ +EE+ + QE G+EE
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE 835
Query: 1077 ------NERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRL 1129
E+ G+E K K++G + + Q++ + + +EQ KM Q +++
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQGQEEKMRE---QEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 139 bits (349), Expect = 2e-32
Identities = 168/633 (26%), Positives = 298/633 (47%), Gaps = 70/633 (11%)
Query: 539 TENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKG 598
T + +D Y E + K+ + + + + T E + E+ E+ AE
Sbjct: 190 TRHKKADRYIE-------ELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES--- 239
Query: 599 NGIEEQEVEANEENVKVHGGRKE------KTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652
E+ E++ N + +K R + +T L +++ + E + K + + E+
Sbjct: 240 ---EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE--- 293
Query: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME-------RPGEGEKELAEKEEWKKR 705
+ W+ EER + ++ K R + E R E EKEL E+E+ +
Sbjct: 294 --------------KMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
Query: 706 DGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE 765
E +EQ+E+ Q +++ ++ E+ E+E +EE R E+EK+ +E+ ++ E
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEE 397
Query: 766 GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE 825
E++E R+KEER ++EK E Q E EE + + +EK+ + E + EE E
Sbjct: 398 RMWEQDERLREKEERMREQEKMWE---QVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454
Query: 826 REE---EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE---GEEEGEEGEGEGE 879
RE+ EEEE E+EE ++EE E+EE E + + E+ E +E+ +E E +
Sbjct: 455 REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW 514
Query: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEE---GEEGEGEGEEEE 936
E+E + +EE G+ E++ E E E + E+E + + +E+ +E E + +E
Sbjct: 515 EQEEKIRDQEEMWGQ-EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
Query: 937 GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996
E + D E + EEE E E++ E EEE E EE E EE+ E E + E E
Sbjct: 574 QEKKTWDQEEKMREEERMREREKKMRE---EEEMMREQEEKMQEQEEKMQEQEEKMWEQE 630
Query: 997 EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE---EGEEEGEEREKEGEGE 1053
E+ +E+ E E E + E+EE E + E+ E E E E E+ E+ EK E E
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Query: 1054 ENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTY-QKKSVTNTQ 1112
+ + +E+E++ ++ EEE+ R E KK+ + + ++ + K Q++ + +
Sbjct: 691 KMEKKTQEQEKKTWDQEKMREEESMR---EREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
Query: 1113 GNGKEQRSKMPVQSKRLLKNG--PSGSKKFWNN 1143
EQ KM Q +++ + P +K W +
Sbjct: 748 EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 149 bits (375), Expect = 2e-35
Identities = 105/335 (31%), Positives = 173/335 (51%), Gaps = 16/335 (4%)
Query: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVK--LAACGRN-H 98
CG + V+ N + G ++G+LG G+ + T + AL+ V + +CG + H
Sbjct: 4034 CGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGH 4093
Query: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
++ TE G V++ G + G+LG G+++ + I E ++ Q+S G SA +T D
Sbjct: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGE-EVVQMSCGFKHSAVVTSD 4152
Query: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGEL-YVFG 215
G+LF +G+ G++GL N SN +P++VT G + ++CG H+ V+ DG + + FG
Sbjct: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQ 273
+ + GKLGL N + +PQ + + I+ VACG + +V LT++ VYTFG +
Sbjct: 4213 DGDYGKLGLGNSTAKS--SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
Query: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333
L G + P+ I + I ++ G HT + G +Y +G G+LGLG
Sbjct: 4271 LPEGRAR-NHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG--- 4326
Query: 334 FTNHF-IPTLCSNFLRFIVKLVACGGCHMVVFAAP 367
TNH PTL + V+ ++ G CH + AP
Sbjct: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAP 4361
Score = 146 bits (369), Expect = 1e-34
Identities = 106/323 (32%), Positives = 167/323 (51%), Gaps = 17/323 (5%)
Query: 52 GNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYAT 111
G +Y++G+ GQL ++ + + ++V CG+N T V G V A
Sbjct: 3995 GKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQV---ICGQNCTFVIQANGTVLAC 4051
Query: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQL--SAGSN-TSAALTEDGRLFMWGDNS 168
G + G+LG G++++ + VIS + QL S GS+ S ALTE G +F WGD
Sbjct: 4052 GEGSYGRLGQGNSDDLHVLTVISALQG-FVVTQLVTSCGSDGHSMALTESGEVFSWGDGD 4110
Query: 169 EGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPN 226
G++G N P+Q+ G+ V +SCG+ HSA VT+DG+L+ FG + G+LGL N
Sbjct: 4111 YGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGN 4170
Query: 227 QLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENA--VYTFGLGQFGQLGLGTFLFET 283
N + P+ V+ + ++ QVACG HT+ ++ + V+ FG G +G+LGLG ++
Sbjct: 4171 --TSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKS 4228
Query: 284 SEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLC 343
S P+ I+ + I ++CG + +T G +YTFG R +GL NH P
Sbjct: 4229 S-PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR--LIGLPEGRARNHNRPQQI 4285
Query: 344 SNFLRFIVKLVACGGCHMVVFAA 366
I++ VA G H + A+
Sbjct: 4286 PVLAGVIIEDVAVGAEHTLALAS 4308
Score = 143 bits (360), Expect = 1e-33
Identities = 88/277 (31%), Positives = 150/277 (54%), Gaps = 10/277 (3%)
Query: 41 SCG-DEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
SCG D HS +T + +++ +G ++G+LG G+ +P ++AL+ E+V +CG H+
Sbjct: 4087 SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4146
Query: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
V T G ++ G + G+LGLG+T + ++ ++I Q++ G N + A++ DG
Sbjct: 4147 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-YQIGQVACGLNHTLAVSADG 4205
Query: 160 RL-FMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGE 216
+ + +GD G++GL N + PQ++ + G + ++CG S +T DG +Y FG
Sbjct: 4206 SMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG- 4264
Query: 217 PENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ-VACGGEHTVVLTENA-VYTFGLGQFGQL 274
++ +GLP NH PQ + + +I+ VA G EHT+ L N VY +G GQL
Sbjct: 4265 -QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQL 4323
Query: 275 GLGTFLFETSEPKVIENIRDQTISYISCGENHTALIT 311
GLG EP ++ ++ + + IS G H+A T
Sbjct: 4324 GLG-HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 122 bits (306), Expect = 2e-27
Identities = 85/267 (31%), Positives = 143/267 (53%), Gaps = 19/267 (7%)
Query: 8 MPDSGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLY 57
+ +SG VF++G + + G + + V +SCG +HSAVVT + KL+
Sbjct: 4097 LTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLF 4156
Query: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL-VSTEGGNVYATGGNNE 116
FG+ ++G+LGLG+ S P V AL+ ++ ACG NHTL VS +G V+A G +
Sbjct: 4157 TFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDY 4216
Query: 117 GQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKN 176
G+LGLG++ +++ I IK+++ G+ S ALT+DG ++ +G + +
Sbjct: 4217 GKLGLGNSTAKSSPQKIDVLCG-IGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGR 4275
Query: 177 VSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNH-R 233
N PQQ+ + G + ++ G H+ + ++G++Y +G G+LGL + NH R
Sbjct: 4276 ARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT---NHVR 4332
Query: 234 TPQLVSEIPEK-VIQVACGGEHTVVLT 259
P LV+ + K V Q++ G H+ T
Sbjct: 4333 EPTLVTGLQGKNVRQISAGRCHSAAWT 4359
Score = 111 bits (278), Expect = 3e-24
Identities = 89/334 (26%), Positives = 157/334 (47%), Gaps = 13/334 (3%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG---SKSAISKPTCVKALKPEKVKLAACGR 96
+ G + V++ + + G ++G+LGLG ++S + K T +KV +
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSD 467
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
HTL T G V++ G + G+LG G++ + +I + +SAG SAA+T
Sbjct: 468 GHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVT 527
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGE-LYVFG 215
EDG L+ WG+ G++G + ++ +P V V +SCG H+ ++ DG ++ FG
Sbjct: 528 EDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG 587
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVAC-GGEHTVVLTENA-VYTFGLGQFGQ 273
+NGKLG + P+++ + I+ C G + ++ LT VY +G G
Sbjct: 588 GGDNGKLGHGD--TNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCG--AC 643
Query: 274 LGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLEN 333
LG G+ PK+IE + I +S G++H ++ +Y +G+ G+ G G N
Sbjct: 644 LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG--N 701
Query: 334 FTNHFI-PTLCSNFLRFIVKLVACGGCHMVVFAA 366
T P S ++ ++ G H + + A
Sbjct: 702 STGPITKPKKVSGLDGIAIQQISAGTSHSLAWTA 735
Score = 90.9 bits (224), Expect = 6e-18
Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 9/228 (3%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
V V +S G HSA VT + +LY +G ++G+LG G ++ + PT VK + V +CG
Sbjct: 512 VVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCG 569
Query: 96 RNHTL-VSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
+HT+ +S +G V++ GG + G+LG GDT VI I+++ AGS +S A
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMF-IRKVCAGSQSSLA 628
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNV--CVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
LT G+++ WG + G + + + +++ + V +S G H ++ D E+Y
Sbjct: 629 LTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVD-VSIGDSHCLALSHDNEVY 687
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT 259
+G G+ G N G P+ VS + I Q++ G H++ T
Sbjct: 688 AWGNNSMGQCGQGNS-TGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 87.4 bits (215), Expect = 7e-17
Identities = 63/223 (28%), Positives = 109/223 (48%), Gaps = 13/223 (5%)
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVF 214
++E +++WG NS Q+ + P+ I G Y + ++TDG +
Sbjct: 368 VSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRAC 427
Query: 215 GEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGE----HTVVLT-ENAVYTFGLG 269
G+ G+LGL + N T + ++ P + I+ + HT+ T E V+++G G
Sbjct: 428 GKGSYGRLGLGDS--NNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
Query: 270 QFGQLGLGTFLFETSEPKVIEN-IRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
+G+LG G + PK+I+ ++ + + +S G H+A +T+ G +YT+G+G G+LG
Sbjct: 486 DYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
G N N IPTL + V V+CG H + + R V
Sbjct: 545 HGDSNSRN--IPTLVKDISN--VGEVSCGSSHTIALSKDGRTV 583
Score = 33.1 bits (74), Expect = 1.6
Identities = 17/58 (29%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 697 AEKEEW--KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752
+ ++ W + +D + + +E + EMEE E + EG E D EEE E E
Sbjct: 1321 SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHE 1378
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 140 bits (354), Expect = 5e-33
Identities = 175/633 (27%), Positives = 289/633 (45%), Gaps = 73/633 (11%)
Query: 494 GETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEM 553
GE D+++ H + E LS V QKK+ +D Y E
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKK-----------------ADRYIE---- 196
Query: 554 KEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENV 613
+ K+ + + + + T E ++ ++ E+ + E E+ E++ N + +
Sbjct: 197 ---ELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES------EKSEIQLNVKEL 247
Query: 614 KVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE 673
K + E+ ++L +AE A +G+ + EE E W
Sbjct: 248 K---RKLERAKLLLPQQQLQAE-----ADHLGKELQSVSAKLQAQVEEN----ELWNRLN 295
Query: 674 REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE 733
+++ EK M R E +E EK + ++ EQE+K REQ + R +EM EE
Sbjct: 296 QQQEEK------MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 734 EHGEGEEEEGDREEEEEKEGE---GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790
+ EE ++EE+ ++ E KEE + E EKEE R+ EE+ ++EK E
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE- 408
Query: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE 850
Q E +EE + R +EK + E + EE RE+EE+ E E++ EE+ E E
Sbjct: 409 --QEEKRQEEEKIREQEKRQEQEAKMWRQEEKI--REQEEKIREQEKKMWRQEEKIHEQE 464
Query: 851 EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEG-EEEGE 909
+ E K +E+ E EE+ E E ++E E EE+ + E+ + E E+ E
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEE 524
Query: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE---DGEGEGEEEEGEWEGEEEEGEGE- 965
E+EE + EE+ E E EEE E E + E E+E+ W EE+ E E
Sbjct: 525 KIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEE 584
Query: 966 ---GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022
+EE E EE E EE+ + E + E EE+ +E+ E E E + E+EE E
Sbjct: 585 KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Query: 1023 GEVE-GEEGEGEGEEEEGEEEGEE---REKEGEGEENRRNREEEE---EEEGKYQETGEE 1075
E + GE+ E E+EE +E EE R++E E+ ++ RE+EE E+E QE E+
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 704
Query: 1076 --ENERQDGEEYKKVSKIKGSVKYGKHKTYQKK 1106
E E + E+ +K+ + + ++ + K ++++
Sbjct: 705 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Score = 55.5 bits (132), Expect = 3e-07
Identities = 62/237 (26%), Positives = 110/237 (46%), Gaps = 9/237 (3%)
Query: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
+ + EE E + ++ EE EE+ E E + E E + E E + E+E + +E
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEE---EGEEEGEGEEEGEGEGEEEEEGEVEGEV 1025
E E EE EE E E + EE E EE+ +EE E +EE+ E+E ++
Sbjct: 342 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKIRELEEKM 400
Query: 1026 EGEEGEGEGEEEEGEEEG-EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
+E E EE+ EEE E+EK E E +EE+ E+ + E++ RQ+ +
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFW 1141
+++ + + + + ++++ + Q Q+ KM Q +++ K +K W
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQ----EEKVW 513
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 140 bits (354), Expect = 5e-33
Identities = 115/344 (33%), Positives = 166/344 (48%), Gaps = 29/344 (8%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
VP SC H + T + G + GQLGLG K + ++ PE V A G
Sbjct: 34 VPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAG 92
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
HT+ ++ G VY+ G N+EG LG DT + V + K+ Q+SAG + +AAL
Sbjct: 93 GMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAAL 151
Query: 156 TEDGRLFMWGD--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELY 212
T+DGR+F+WG ++ G IGL + + VP QV + PV ++ G H +T DG+LY
Sbjct: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLY 211
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVV 257
G E G+LG +L N Q + +P+ V+ CG T
Sbjct: 212 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFA 271
Query: 258 LT-ENAVYTFGLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDI 313
++ E VY FGL + QLG GT P+ + + ++ T S++ S G++HT +
Sbjct: 272 ISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSE 329
Query: 314 GLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
G Y+ G +G+LGLG E IPTL S V VACG
Sbjct: 330 GKAYSLGRAEYGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 370
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 68 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 126
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 127 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQ-- 184
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL-----------KNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+G + + + VP+
Sbjct: 185 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGT--ESCFIPQN 302
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 303 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 361
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 362 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 420
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 421 VSSGGQHTVL 430
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 151 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 208
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 267
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 268 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 325
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 326 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 385
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 386 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 434
Score = 61.2 bits (147), Expect = 5e-09
Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 42 CGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAAC--GRNHT 99
CG + ++ +Y FG +N+ QLG + P + + K G++HT
Sbjct: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHT 323
Query: 100 LVSTEGGNVYATGGNNEGQLGLGD-TEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
+ G Y+ G G+LGLG+ EE++ +IS + + ++ G++ A+T+D
Sbjct: 324 VCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA---VSSVACGASVGYAVTKD 380
Query: 159 GRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP-----VSWISCGYYHSAFVTTDGE 210
GR+F WG + Q+G + P ++ +GK V +S G H+ + D E
Sbjct: 381 GRVFAWGMGTNYQLGTGQDEDAWSPVEM-MGKQLENRVVLSVSSGGQHTVLLVKDKE 436
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 139 bits (349), Expect = 2e-32
Identities = 96/287 (33%), Positives = 151/287 (52%), Gaps = 9/287 (3%)
Query: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
G+ HS ++ N+++ G N+ GQLG P ++AL+ V L +CG+ H+L
Sbjct: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
Query: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLF 162
G V+A G +EGQLG+G+ +E + ++ KI Q+S G S AL++D ++F
Sbjct: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
Query: 163 MWGDNSEGQIGL-KNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPEN 219
WG NS GQ+GL K + PQ+V G P++ ++ G HS ++ G + +G
Sbjct: 151 SWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
Query: 220 GKLGLPNQLLG-NHRTPQLVSEIPE-KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGL 276
G+L L + + P V + V+ ++CG HT VLT++ V+TFG + GQLG
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGY 270
Query: 277 GTFLFETSEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDG 322
E P+++E I D +S I CG HT A + G + +FG G
Sbjct: 271 SP-TPEKRGPQLVERI-DGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
Score = 119 bits (297), Expect = 2e-26
Identities = 83/238 (34%), Positives = 119/238 (50%), Gaps = 10/238 (4%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAIS-KPTCVKALKPEKVKLAACGRNH 98
+SCG EHS V +++ +G+ + GQLG+G IS P + L K+ +CG H
Sbjct: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 99 TLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTED 158
+L ++ V++ G N+ GQLGLG + Q++AG S AL+
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLC 199
Query: 159 GRLFMWGDNSEGQIGL--KNV---SNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
G F WG NS GQ+ L +NV SN + V +ISCG H+A +T DG+++
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV--VLTENAVYTFGLG 269
FG+ +G+LG R PQLV I V Q+ CG HT+ V T V +FG G
Sbjct: 260 FGDNRSGQLGY--SPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
Score = 115 bits (289), Expect = 2e-25
Identities = 75/244 (30%), Positives = 126/244 (51%), Gaps = 9/244 (3%)
Query: 92 AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNT 151
AA G H+L+ V + G N+ GQLG + I + + +S G
Sbjct: 28 AASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI-VDLVSCGKEH 86
Query: 152 SAALTEDGRLFMWGDNSEGQIGLKNVSNVC-VPQQVTIGKPVSWI--SCGYYHSAFVTTD 208
S A+ GR+F WG SEGQ+G+ + P+++ + I SCG+YHS ++ D
Sbjct: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
Query: 209 GELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTE-NAVYTF 266
+++ +G+ +G+LGL + + +PQ V + + QVA GG H+ L+ + +
Sbjct: 147 SQVFSWGKNSHGQLGLGKEF-PSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGW 205
Query: 267 GLGQFGQLGLG--TFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324
G GQL L ++++P + +++ + YISCG+ HTA++T G ++TFGD R
Sbjct: 206 GSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Query: 325 GKLG 328
G+LG
Sbjct: 266 GQLG 269
Score = 91.3 bits (225), Expect = 5e-18
Identities = 74/233 (31%), Positives = 112/233 (48%), Gaps = 14/233 (6%)
Query: 18 GKSKFAENNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSK-SAI 75
G+ K P K ND+ + +SCG HS ++ +++++ +G N+ GQLGLG + +
Sbjct: 110 GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQ 169
Query: 76 SKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISF 135
+ P V++L+ + A G H+ + G + G N+ GQL L RN +
Sbjct: 170 ASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSG---RNVPVQSNK 226
Query: 136 FTSEHKIKQL-----SAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-TIG 189
S +K L S G +A LT+DG++F +GDN GQ+G PQ V I
Sbjct: 227 PLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERID 286
Query: 190 KPVSWISCGYYHS-AFVTTDGELYVFGE--PENGKLGLPNQLLGNHRTPQLVS 239
VS I CG YH+ A+V T G++ FG + K P L N L+S
Sbjct: 287 GLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDISCLIS 339
Score = 87.4 bits (215), Expect = 7e-17
Identities = 59/228 (25%), Positives = 112/228 (49%), Gaps = 6/228 (2%)
Query: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCG 198
++ Q ++G S L + R+ GDNS GQ+G + +P+ + + V +SCG
Sbjct: 24 ELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCG 83
Query: 199 YYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVV 257
HS V G ++ +G G+LG+ + TP+ + + + K+IQV+CG H++
Sbjct: 84 KEHSLAVCHKGRVFAWGAGSEGQLGI-GEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLA 142
Query: 258 LTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
L++++ V+++G GQLGLG + P+ + ++ ++ ++ G H+ ++ G
Sbjct: 143 LSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTS 202
Query: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI-VKLVACGGCHMVV 363
+ +G G+L L N L L+ + V ++CG H V
Sbjct: 203 FGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAV 250
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 138 bits (348), Expect = 3e-32
Identities = 122/472 (25%), Positives = 212/472 (44%), Gaps = 37/472 (7%)
Query: 648 EDGPEGRGDGTCEEGSS-GAEHWQDEEREKG-EKDKGRGEMERPGEGEK---ELAEKEEW 702
E G G G+G + G E ++ +KG EKDK + + +GE E++E +
Sbjct: 4676 EGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDG 4735
Query: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE 762
K DGE +EQ+E ++ + EGG+ + G+ + ++ +E+ +E E E
Sbjct: 4736 KMHDGELEEQEEDDE-------KSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDE 4788
Query: 763 EVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEG 822
E E + +E G EE + K + +++ + + EEKEE +GG+ E+
Sbjct: 4789 EEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDK 4848
Query: 823 KGEREEEEEEGEGEEEEGEGEEEEGEGEE----------EEGEGKGEEEGEEGEGEEEGE 872
E+ +E + E E + G +E+ E + + G E+ + EGEEE
Sbjct: 4849 INEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENP 4908
Query: 873 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEG 932
E EE G E EE GE E ++ E + E E EG E+ + +GEEE + G
Sbjct: 4909 LEIKEKPEEAGH-EAEERGETETDQNESQSPQEPE---EGPSEDDKAEGEEEMDTG---A 4961
Query: 933 EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEG-EGEEGEGEGEEEEGEGEGE 991
++++G+ + E EE++ E +++E + EG E G +G + + E E E+ + E +
Sbjct: 4962 DDQDGDA-AQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQ 5020
Query: 992 EEEGEEEGEEEGEGE---EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048
E E E G+ E + E G + +G+E G G + + EG E
Sbjct: 5021 VPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNF 5080
Query: 1049 EGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKH 1100
+ + R+ + + K G+ +NER G+ ++V K +V H
Sbjct: 5081 IAQLASQKHTRKNTQSFKRK---PGQADNERSMGDHNERVHKRLRTVDTDSH 5129
Score = 136 bits (343), Expect = 1e-31
Identities = 108/375 (28%), Positives = 184/375 (49%), Gaps = 32/375 (8%)
Query: 732 EEEHGEGEEEEGDREEEEEKEGEGKEE-----GEGEEVEGEREKEEGERKKEERAGKEEK 786
E+ GEG E D E EGEG ++ G E+VE +K + + K++ + + K
Sbjct: 4662 EDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIK 4721
Query: 787 GEE---------EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEE-----EE 832
GE+ +G +GE EE E E +E + EGG++++ G+ EE E
Sbjct: 4722 GEDNAIEMSEDFDGKMHDGELEEQE----EDDEKSDSEGGDLDKHMGDLNGEEADKLDER 4777
Query: 833 GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE---EGEGEEEGEEGEGEGEEEEGEGEGEE 889
G+++E E EEEE EE G G EE+ E + + + G + + ++++ E + E
Sbjct: 4778 LWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEA 4837
Query: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949
E + G+ E+ E +E + + E + +E+ E E ++ + ED G GE
Sbjct: 4838 EADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNG-GE 4896
Query: 950 EEEGEWEGEEE---EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
+ + E EGEEE E + + EE G E GE E ++ E + E EEG E +++ EGE
Sbjct: 4897 DTDNE-EGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSE-DDKAEGE 4954
Query: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
EE + ++++ + E E + + EE+ +E EE + G ++ + +EEEE E+
Sbjct: 4955 EEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERED 5014
Query: 1067 GKYQETGEEENERQD 1081
+E E ER++
Sbjct: 5015 SDTEEQVPEALERKE 5029
Score = 135 bits (341), Expect = 2e-31
Identities = 151/624 (24%), Positives = 265/624 (42%), Gaps = 62/624 (9%)
Query: 490 VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIG-------ELTQDTALTEND 542
V L +D++ MSL ++ + KL V Q + E +D+A
Sbjct: 4611 VPVLSSYSDLVLFFLTMSLATHRSTAKLLSVLAQVFTELAQKGFCLPKEFMEDSAGEGAT 4670
Query: 543 DSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIE 602
+ +YE + EG+ K Q Q T + +++ E P+ K D KG E
Sbjct: 4671 EFHDYEG-GGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKS---DIKG---E 4723
Query: 603 EQEVEANEE-NVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEE 661
+ +E +E+ + K+H G E+ E E KS E D + GD EE
Sbjct: 4724 DNAIEMSEDFDGKMHDGELEEQE-------------EDDEKSDSEGGDLDKHMGDLNGEE 4770
Query: 662 GSSGAEH-WQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ 720
E W D++ E+ E+++ + E G G E E E +D + Q
Sbjct: 4771 ADKLDERLWGDDDEEEDEEEEDN-KTEETGPGMDE--EDSELVAKDDNLDSGNSNKDKSQ 4827
Query: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK----EEGERK 776
+++ +E EE ++ G+GE++ ++ +E + + E E + G +EK E +
Sbjct: 4828 QDKKEEKEEAEADDGGQGEDKINEQIDERDYD-----ENEVDPYHGNQEKVPEPEALDLP 4882
Query: 777 KEERAGKEEK-GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE-GKGEREEEEEEGE 834
+ E+K G E+ D EGEEE E+ EE G E EE G+ E ++ E +
Sbjct: 4883 DDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGH----EAEERGETETDQNESQSP 4938
Query: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGE 894
E EEG E+++ EGEEE G +++G+ + EE E + + EE+ + E +EEG
Sbjct: 4939 QEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDK-EADEEGGEN 4997
Query: 895 GEEEEG--EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952
G ++G E EE + + EE+ E +E G E + + G E+E
Sbjct: 4998 GPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKE 5057
Query: 953 GEWEGEEEEGEGEGE-EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG 1011
+G+EE G G + + EG + ++ + + + G+ + E
Sbjct: 5058 ---QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHN 5114
Query: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEE-EGEEREKEGEG-------EENRRNREEEE 1063
E + V+ + E+G + + + E+ + E K+G + + +++
Sbjct: 5115 ERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSA 5174
Query: 1064 EEEGKYQETGEEENERQDGEEYKK 1087
++ GK QE E E+ D EE ++
Sbjct: 5175 KDSGKDQEEEEIEDTLMDTEEQEE 5198
Score = 133 bits (335), Expect = 8e-31
Identities = 113/453 (24%), Positives = 210/453 (46%), Gaps = 31/453 (6%)
Query: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
GEG E + E +GE + + G++ E+ ++ + G+E+ E + + D + E+
Sbjct: 4666 GEGATEFHDYEGGGIGEGEGMKDVSDQIGNE-EQVEDTFQKGQEKDKEDPDSKSDIKGED 4724
Query: 750 EKEGEGKEEGEGEEVEGE-REKEEGERKKEERAGKEEK--GEEEGDQGEGEEEETEGRGE 806
E E+ +G+ +GE E+EE + K + G +K G+ G++ + +E G +
Sbjct: 4725 NAI-EMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDD 4783
Query: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG- 865
E+E+ E + E G G EE+ E ++ G + + ++++ E K E E ++G
Sbjct: 4784 EEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGG 4843
Query: 866 EGEEEGEEGEGEGEEEEGE-----GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK 920
+GE++ E E + +E E G E+ E E + + + E + GE+ + E +
Sbjct: 4844 QGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNE-E 4902
Query: 921 GEEEG-----EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE 975
GEEE E+ E G E E GE E + E + + EG E+ + EGEEE + +
Sbjct: 4903 GEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGAD 4962
Query: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
+ +G+ + E E+++ E E++ E +EEG G ++ + + E E E+ + E +
Sbjct: 4963 DQDGDAAQHPEEHSEEQQQSVE--EKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQ 5020
Query: 1036 EEEGEEEGEEREKEGEGEENRRNRE-------EEEEEEGKYQE-TGEEENERQDGEEYKK 1087
E E E G EN +N + E+E+GK + +G + + +G E
Sbjct: 5021 VPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNF 5080
Query: 1088 VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRS 1120
++++ KH +S G +RS
Sbjct: 5081 IAQLASQ----KHTRKNTQSFKRKPGQADNERS 5109
Score = 124 bits (310), Expect = 7e-28
Identities = 105/402 (26%), Positives = 187/402 (46%), Gaps = 20/402 (4%)
Query: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG-EGEEEETEG 803
+E E+ GEG E E G E E G + ++ G EE+ E+ +G E ++E+ +
Sbjct: 4658 KEFMEDSAGEGATEFHDYEGGGIGEGE-GMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDS 4716
Query: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
+ + K E +E E +GK +GE EE+E + E+ + EG + + + G+ GE
Sbjct: 4717 KSDIKGEDNAIEMSEDFDGK------MHDGELEEQEEDDEKSDSEGGDLD-KHMGDLNGE 4769
Query: 864 EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG-EEEEGEGEGEEEGEGEGEEEEGEGKGE 922
E + +E G+ + EE+E E + + E G G +EE+ E +++ G + K +
Sbjct: 4770 EADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKD--KSQ 4827
Query: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
++ +E + E E ++G G+GED E +E E E + G E+ E E + +
Sbjct: 4828 QDKKEEKEEAEADDG-GQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLN 4886
Query: 983 EEEGEGEGEEEEGEEEGEEEG--EGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE 1040
+ + G E+ EEGEEE E +E+ E G E EE GE E ++ E + +E
Sbjct: 4887 LDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEE---RGETETDQNESQSPQEP-- 4941
Query: 1041 EEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKH 1100
EEG + + EGEE ++++ + E ++Q EE K + +G
Sbjct: 4942 EEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPAD 5001
Query: 1101 KTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWN 1142
+ +Q + + + E++ ++ K G +G + N
Sbjct: 5002 QGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQN 5043
Score = 90.5 bits (223), Expect = 8e-18
Identities = 121/566 (21%), Positives = 225/566 (39%), Gaps = 85/566 (15%)
Query: 535 DTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAF---SDEEVEIPEEKE 591
D L E ++ DE + EG +H+ G + A ++ D+E E EE++
Sbjct: 4739 DGELEEQEEDDEKSD----SEGGDLDKHM--GDLNGEEADKLDERLWGDDDEEEDEEEED 4792
Query: 592 GAEDSKGNGIEEQEVE--ANEENVKVHGGRKEKTEILSDDLTDKAEVSEG-----KAKSV 644
+ G G++E++ E A ++N+ K+K++ + ++AE +G K
Sbjct: 4793 NKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQ 4852
Query: 645 GEAEDGPEGRGD---GTCEE---------------GSSGAEHWQDEEREKGEKDKGRGEM 686
+ D E D G E+ S +D + E+GE++
Sbjct: 4853 IDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIK 4912
Query: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQK----ERNQEMEEGGEEEHGEGEEEE 742
E+P E E E+ E + E Q +E E+G + E +EM+ G +++ G+ +
Sbjct: 4913 EKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHP 4972
Query: 743 GDREEE-----EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGE 797
+ EE EEK+ E EEG GE ++ G + + EEE + + E
Sbjct: 4973 EEHSEEQQQSVEEKDKEADEEG-GENGPADQ-------------GFQPQEEEEREDSDTE 5018
Query: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGK 857
E+ E E KE + G E + E G E+E +G+EE G G + + +
Sbjct: 5019 EQVPEAL-ERKEHASCGQTG--VENMQNTQAMELAGAAPEKE-QGKEEHGSGAADANQAE 5074
Query: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
G E + + + + + G+ + E G+ E +
Sbjct: 5075 GHESNFIAQLASQ--------KHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDT 5126
Query: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
+ E +G ++ + + ED + ++G + + + +E+ + + G
Sbjct: 5127 DSHAE--------QGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSG 5178
Query: 978 EGEGEEEEGEGEGEEEEGEE---EGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEG 1034
+ + EEE + + EE EE E+ + EE G E+E E++ +
Sbjct: 5179 KDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVK----- 5233
Query: 1035 EEEEGEEEGEEREKEGEGEENRRNRE 1060
EE+ + ++ KE E E+ R+RE
Sbjct: 5234 TEEDQDPRTDKAHKETENEKPERSRE 5259
Score = 59.3 bits (142), Expect = 2e-08
Identities = 105/487 (21%), Positives = 186/487 (38%), Gaps = 69/487 (14%)
Query: 476 DEMTKEAEIDNSSTVESLGETTD----ILNMTHIMSLNSN-EKSLKLSPVQKQKKQQTIG 530
DE E E DN + G + + ++ S NSN +KS + +K++ + G
Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDG 4842
Query: 531 ELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEK 590
+D + E D +Y+E +E+ ++ V + + P D+ E+K
Sbjct: 4843 GQGEDK-INEQIDERDYDE-NEVDPYHGNQEKVPEPEALDLP--------DDLNLDSEDK 4892
Query: 591 EGAEDSKGN-GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAED 649
G ED+ G EE +E E+ + +E+ E +D ++ + S + +
Sbjct: 4893 NGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAE 4952
Query: 650 GPEGRGDGTCEEGSSGAEHWQD--EEREKGEKDKGRGEMERPGEGEK-----ELAEKEEW 702
G E G ++ A+H ++ EE+++ ++K + E GE + E+EE
Sbjct: 4953 GEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEER 5012
Query: 703 KKRDGEEQ-----EQKEREQGHQK-----ERNQEME--------EGGEEEHGEGEEEEGD 744
+ D EEQ E+KE Q + Q ME E G+EEHG G +
Sbjct: 5013 EDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQ 5072
Query: 745 REEEEE--------KEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE----------EK 786
E E ++ K + G+ + E ER K E+
Sbjct: 5073 AEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQ 5132
Query: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV----------EEGKGEREEEEEEGEGE 836
G + Q + E+ + ++ + + + +V + GK + EEE E+ +
Sbjct: 5133 GPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMD 5192
Query: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896
EE E + + + E K G E E E + EE++ + E E E
Sbjct: 5193 TEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENE 5252
Query: 897 EEEGEGE 903
+ E E
Sbjct: 5253 KPERSRE 5259
Score = 48.5 bits (114), Expect = 4e-05
Identities = 91/468 (19%), Positives = 173/468 (36%), Gaps = 103/468 (22%)
Query: 461 SEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPV 520
+++ + +PE D L D++ ++E N GE TD NE+ + +P+
Sbjct: 4869 NQEKVPEPEALD-LPDDLNLDSEDKNG------GEDTD------------NEEGEEENPL 4909
Query: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMT--------QP 572
+ ++K + G ++ TE D + E + E +EG + M
Sbjct: 4910 EIKEKPEEAGHEAEERGETETDQN-ESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDA 4968
Query: 573 ATTIEAFSDEEVEIPEEKEGAEDSKG--NGIEEQEVEANEENVKVHGGRKEKTEILSDDL 630
A E S+E+ + EEK+ D +G NG +Q + EE + +E+ + + L
Sbjct: 4969 AQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQ---VPEAL 5025
Query: 631 TDKAEVSEGK--------------AKSVGEAEDGPEGRGDGTCEEGSSGA---------- 666
K S G+ A + E E G E G G + +
Sbjct: 5026 ERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLA 5085
Query: 667 ------EHWQDEEREKGEKDKGR------------------------GEMERPGEGEKEL 696
++ Q +R+ G+ D R G ++P + + E
Sbjct: 5086 SQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQP-QAQVED 5144
Query: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756
A+ E K+ + + + + ++++ + G ++E E E+ D EE+EE +
Sbjct: 5145 ADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADV 5204
Query: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG 816
E+ + EE++ G + E + E++ + + +ETE E+ +
Sbjct: 5205 EQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHT 5264
Query: 817 G--------------EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE 850
+V E + E E + E + E G EEE+ E
Sbjct: 5265 AHQFLMDTIFQPFLKDVNELRQELERQLEMWQ-PRESGNPEEEKVAAE 5311
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 138 bits (347), Expect = 3e-32
Identities = 149/638 (23%), Positives = 277/638 (43%), Gaps = 53/638 (8%)
Query: 512 EKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQ 571
++ L+ P Q++++++ Q+ L E ++ E +E E ++ +Q + ++ +
Sbjct: 126 DRQLEEEPGQRRRQKRQ----EQERELAEGEEQSEKQERLEQRD----RQRRDEELWRQR 177
Query: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
E E E+E + KG+ EE +EE ++ R+E E+
Sbjct: 178 QEW------QEREERRAEEEQLQSCKGHETEEFP---DEEQLR----RRELLELRRKGRE 224
Query: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTC---------EEGSSGAEHWQDEERE--KGEKD 680
+K + + V + E+ E R T EE Q+EE + K E+
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 681 KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE 740
+ R E + + ++ L +++ +++ EE+ +++ E+ Q+ER ++ EE E++ +E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEE 800
E +++ E+E E +E+ E E ER +++ R+++ R ++ + E++ + + E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG--KG 858
+ R E++ + ++ + R E+EEE ++ E E E+ + E+EE K
Sbjct: 405 QQLRREQQLRREQ----QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 859 EEEGEEGEGEEEGEEGEGEGEEEEGE-----GEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
EEE E E E ++ + + EEE E E E + E E++ E EE E +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 914 EEEGEGK-----GEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
+E E + E+ E E E+ E+ E E E + E+EE + +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
E ++ +EE E + EE E +EE + E EEE ++ E E
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 1029 EGEGEGEEEEGEEEGEEREKEGEGEENRRNR-EEEEEEEGKYQETGEEENERQDGEEYKK 1087
E + E +E E+R K E EE R + E EEE + QE EEE E+ +
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 1088 VSK----IKGSVKYGKHKTYQKKSVTNTQGNGKEQRSK 1121
+ K ++ + K Y + Q +EQ K
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Score = 136 bits (342), Expect = 1e-31
Identities = 121/477 (25%), Positives = 218/477 (45%), Gaps = 11/477 (2%)
Query: 659 CEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQG 718
C+ S + + EE ++ + + R E PG+ ++ +++E + +GEEQ +K+ E+
Sbjct: 103 CDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ-ERL 161
Query: 719 HQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE 778
Q++R + EE + E EE EEE+ + +G E E + E R +E E +++
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK 221
Query: 779 ERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838
R K+++ E D+ EEEE E R E E E + EE + +RE +EEE + +
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
E + E + EE++ + E+ + EEE E + E E++ E +EE +
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
E E E++ E EEE E + E EE E + + + + E++ +
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 959 EEEGEGEGEEEGEGEGE---EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015
E + E++ E + E + E+EE E + E+ E + E EE + E
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461
Query: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEE----EGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
EE E E ++ + + EEE E E EER ++ E E + RE+EE E + +
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 1072 TGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKR 1128
EEE +Q + +++ + + + +++ + +EQR K + +R
Sbjct: 522 QEEEERLQQ---RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Score = 132 bits (333), Expect = 1e-30
Identities = 144/591 (24%), Positives = 260/591 (43%), Gaps = 64/591 (10%)
Query: 586 IPEEKEGAEDSKGNGIEEQEVEANEENVKVHGG---------RKEKTEILSDDLTDKAEV 636
+ EEK D K + ++++ E ++ + R++K + +L + E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 637 SEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKD-----KGRGEMERPGE 691
SE + + E R D EE + WQ+ E + E++ KG E P E
Sbjct: 155 SEKQER----LEQRDRQRRD---EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
+ E E +++ EE++Q+ RE+ + + +E +E + E +EEE +EEE ++
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 752 EGEGKEEGEG------EEVEGEREKEEGERKKEERAGK-EEKGEEEGDQGEGEEEETEGR 804
+ E +EE E +E+ ER++EE ++++ R + K EEE + + E E + R
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 805 GEEKEEGGEVEGGEVEEGKGE---REEEEEEGEGEEEEGEGEEEEGEGE--------EEE 853
E++EE E + +E + E R E+EEE ++ E EEE E + E+
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG----- 908
+ ++ E + E + + E + E++ E EEE E + E+E
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
+ E EE K EEE E E E +++ + + E EE W EEE E +E
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQE------EERRERWLKLEEEERREQQE 501
Query: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
E + + E E+ + + EEE ++ E + E E E+ + E E +E E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 1029 EGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE----------EEGKYQETGEEENE 1078
E + E+ E + ++E E + R RE+EE E + +E E+ +
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 1079 RQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRL 1129
R++ EE ++ +K + + +++ + Q +EQR K + +RL
Sbjct: 622 REEPEEERRQQLLKSE----EQEERRQQQLRREQQERREQRLKREEEEERL 668
Score = 132 bits (333), Expect = 1e-30
Identities = 171/704 (24%), Positives = 304/704 (43%), Gaps = 80/704 (11%)
Query: 452 ERNLQESVLSEQDLM--QPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLN 509
E LQ+ + SEQ L Q E + LL + +E ++ + L + ++
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLL-KREEEKRLEQERREQRLKREQEE-RRDQLLKRE 582
Query: 510 SNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEY----EEMSEMKEGKACKQHVSQ 565
+ +L Q+++ +Q + ++ E ++ E EE E + + K +
Sbjct: 583 EERRQQRLKREQEERLEQRLKR--EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 566 GIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVE---ANEENVKVHGGRKEK 622
Q + ++ ++ EE+E E EE+ E A EE + K +
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 623 TEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAE-HWQDEER------- 674
L +A+ + K S ++G R + + +E WQ+EER
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE 760
Query: 675 --------------EKGEKDKGRGEMERPGEGEKE----LAEKEEWKKRDGEEQEQKERE 716
EK E+ + R P ++E E+++ ++R E+E+KE+
Sbjct: 761 EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQR 820
Query: 717 QGHQKERNQEMEEGGEEEHGEG--------EEEEGDREEEEEKEGEGKEEGEGEEVEGER 768
+ ++ER +E++ EEE + EEE+G +E++E + + E+ ++ +
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ--EQRRDQKWRWQL 878
Query: 769 EKEEGERK---------KEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
E+E R+ +E+ +++ +EE ++ + EE E R E++ + E E +
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 820 EEGKGEREEEEEEGEGEEEEG-------EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE 872
EE + REE E+ E E + +EE+ GEE E + E E + E EE +
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 873 EGEGEGEEE-----EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
E E EE E E + + E ++EE + EE + +E E + + EEE ++
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 928 GEGE--GEEEEGEGEGEDGEGEGEEEEGEWEGEE---EEGEGEGEEEGEGE-GEEGEGEG 981
E + GEE E E +EEE + E E+ EE E +E E + EE E +
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Query: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE----EEEEGEVEGEVEGEEGEGEGEEE 1037
EEE+ E E+ +E E + EEE + E E EE E E+E + E E ++
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 1038 EGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQD 1081
E E+ E +++ E R+ REEEE + K ++ +E++R D
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Score = 130 bits (328), Expect = 6e-30
Identities = 158/609 (25%), Positives = 275/609 (45%), Gaps = 58/609 (9%)
Query: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMK----EGKACKQHVSQGI--FMTQPAT 574
Q+++++Q + ++ L + + EE E + E + ++ + I + Q +
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 575 TIEAFSDEEVEIPEEKEGA----EDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDL 630
+A + P ++EG E + E E++ EE + H R+++ E D
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE-RAH--RQQQEEEQRRDF 767
Query: 631 TDKAEVSEGKAKSVGEAEDGPEGRGDGT----CEEGSSGAEHWQDEEREKGEKDKGRGEM 686
T + + E + P R EE + + EE EK ++ + R E
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 687 ERPG---EGEKELAEKEEWKKRDGEE---QEQKEREQGHQKERNQEMEEGGEEEHGEG-- 738
E+ E E++L +E ++ EE QE +ER + ++ R+Q+ EEE
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 739 -------------EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE 785
+E++ +EEEEE + E +E+ +E E + +EE +++EE+ +EE
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 786 KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE 845
+ E+ Q + + + ++KEE ++ G EE + R +E E+ EEEE + EEE
Sbjct: 948 R-EKRRRQERERQYRKDKKLQQKEE--QLLG---EEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 846 EGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE-------EGEGEGEEEGEGEGEEE 898
+ EE E + E E + + +E +E E EE E E + EE E + EEE
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
+ GE E E E E K EE +E E EE + ++ E + EEE E +
Sbjct: 1062 QLLGE-ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE---ELQ 1117
Query: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018
+EE + EE + +E E + EEE + EE+ EE E+ E E + EEE +
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177
Query: 1019 GEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENE 1078
E E + E+ + E E E EE +++ + +R R+E++ + K+Q E+EN
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQ---KRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 1079 RQDGEEYKK 1087
+D + Y K
Sbjct: 1235 VRDNKVYCK 1243
Score = 129 bits (325), Expect = 1e-29
Identities = 158/619 (25%), Positives = 271/619 (43%), Gaps = 60/619 (9%)
Query: 519 PVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEA 578
P+++Q+++Q E Q + +E E+ + + + + Q +
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 579 FSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638
+EE + E++E + ++ + EE + K L + L + ++ +
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA-LQEQLRKEQQLLQ 907
Query: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE----REKGEKDKGRGEMERPGEGEK 694
+ + + E R + E E Q EE RE+ EK + R E ER +K
Sbjct: 908 EEEEELQREEREKRRRQEQ--ERQYREEEQLQQEEEQLLREEREKRR-RQERERQYRKDK 964
Query: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754
+L +KEE + GEE E++ R++ +K R +E E EEE EE E R +E E++
Sbjct: 965 KLQQKEE--QLLGEEPEKRRRQEREKKYREEE-ELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 755 GKEEGEGEEVEGEREKEEGER--KKEERAGKEEKGEEEGDQGEGEEEETEGRGE-----E 807
K+E + EE + RE+ E R ++E + +EE+ ++E +Q GEE ET R E
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 808 KEEGGEVEGGEV--EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
KEE + E ++ EE + R +E E EEEE + EEE+ EE E + E E +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
E EEE ++ E + EE E +E E + EEE + EE+ E +E+ + + +
Sbjct: 1142 E-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGE------------ 973
EE E + ++ + ED + + + +WE E+E + + +G
Sbjct: 1201 EEEELQRQKRKQRYRDED---QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 974 --------------GEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
GE+ E + E+E + + E EE+ E EE+ E + + +
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE--EEQLEREEQKEAKRRDRKSQ 1315
Query: 1020 EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEE----EEEGKYQETG-- 1073
E + + E E +E + EE + E EE R+E + EEE ++QE G
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 1074 --EEENERQDGEEYKKVSK 1090
EEE + E +K K
Sbjct: 1376 FLEEEQRLRRQERERKFLK 1394
Score = 126 bits (316), Expect = 1e-28
Identities = 147/636 (23%), Positives = 288/636 (45%), Gaps = 58/636 (9%)
Query: 520 VQKQKKQQTIGELTQDTALTENDDSDEYEEMS-------EMKEGKACKQHV--SQGIFMT 570
+Q++++ Q + E ++ L E+ + +E +++E + ++H ++
Sbjct: 840 LQRRERAQQLQE--EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 571 QPATTIEAFSDEEVEIPEE---KEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS 627
Q + +EE E+ E K ++ + EE++++ EE + K + +
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE----REKGEKDKGR 683
++ + + + +GE PE R E+ E Q EE RE+ EK + R
Sbjct: 958 RQYRKDKKLQQKEEQLLGEE---PEKRRRQEREKKYREEEELQQEEEQLLREEREKRR-R 1013
Query: 684 GEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG 743
E ER + EL ++EE R E+ +K R Q +++ +E E EEE GEE E
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLR---EEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 744 DREEEEEKEGEGKEEGEGEEVEGEREKEEGERK--KEERAGKEEKGEEEGDQGEGEEEET 801
R +E E++ +EE + EE + RE+ E R+ +E + +EE+ ++E +Q EE E
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 802 EGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE-----EGEG 856
R E + + E E + EE + REE E+ E E EEEE + EEE E E
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE 916
+ +E + EEE + + + + + + + + E E+E + + +G E+
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 917 GEGKGEE-EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE 975
+ + + + + + + GE + D E E + EE + E EE+ E +
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE-------------------E 1016
+ + + E++ E EE+ +E + + EE+ E EE +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 1017 EEG----EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE--EEGKYQ 1070
E+G E E + +E E + +EE + +ERE++ + +R+ REEE++ + + +
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 1071 ETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKK 1106
+ EEE + + E +K + + ++ +H+ ++++
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Score = 125 bits (314), Expect = 2e-28
Identities = 113/439 (25%), Positives = 207/439 (47%), Gaps = 27/439 (6%)
Query: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ-EQKE-------REQGHQK 721
++EE E+ E+++ + +++R E E+ +E W K + EE+ EQ+E REQ ++
Sbjct: 460 REEETERHEQERRKQQLKRDQEEER----RERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 722 ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA 781
E+ + +E E E+ R E+EE+ + + E + +E ER ++ +R++EER
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 782 GKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841
+ K EEE Q + E+ E R E++ + EVE E EE + +R + EE E ++
Sbjct: 576 DQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 901
EE+ E +++ + +E E+ EE EE + + E E E E+ E E+E+
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 902 -------GEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954
+ + + E E + + + +EG+ +E+E + + E + +EEE
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 955 WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014
++EE E + + + EE G + E+ E + E + E E
Sbjct: 755 HRQQQEE-EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER------EKEGEGEENRRNREEEEEEEGK 1068
EEE+ + + E E + EEE + + ER E++G E+ R R +E+ + K
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 1069 YQETGEEENERQDGEEYKK 1087
++ EEE +R+ Y K
Sbjct: 874 WRWQLEEERKRRRHTLYAK 892
Score = 125 bits (314), Expect = 2e-28
Identities = 168/688 (24%), Positives = 283/688 (41%), Gaps = 83/688 (12%)
Query: 462 EQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQ 521
EQ L + EE + L + E ++ E +L L + +L Q
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRR----EQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 522 KQKKQQTIG---ELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEA 578
++++ Q + E Q E ++ E E E ++ Q + +P
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP------ 625
Query: 579 FSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638
+E + + E E+ + + ++ E E+ +K R+E+ E L L K E E
Sbjct: 626 -EEERRQQLLKSEEQEERRQQQLRREQQERREQRLK----REEEEERLEQRL--KREHEE 678
Query: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE-EREKGEKDKGRGEMERPGEGEKELA 697
+ + E+ + R E S WQ + E E + R EG++
Sbjct: 679 ERREQELAEEEQEQAR-----ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 698 EKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG------GEEEHGEG-----------EE 740
E+EE ++R E + +E E+ H++++ +E EE+ G E+
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 741 EEGDREEEEEKEGEGKEEGEGEEVEG------EREKEEGERKKEERAGKEEKGEEEGDQG 794
E EE ++ E + E EE E EREKE ++EE+ + E+ ++ ++
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Query: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGER----------------------EEEEEE 832
+G +E+ E R +++ + ++EE + R EEEEE
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 833 GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGE 892
E E+ +E+E + EEE + + EEE E E+ E E + + + ++E +
Sbjct: 914 QREEREKRRRQEQERQYREEE-QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972
Query: 893 GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952
GEE E E E + EEE + + + EE E +E + E + EEE+
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 953 GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
E E+ E E + EE E + EEE+ GE E +E E + EEE + E
Sbjct: 1033 LLREEREKRRLQERERQYR---EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 1013 GEE--EEEGEVEGEVEGEEGEGEGEEEEGEEE---GEEREKEGEGEENRRNREEEE---E 1064
E+ EE E E E E EE + EEE EEREK E R+ REEEE E
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 1065 EEGKYQETGEEENERQDGEEYKKVSKIK 1092
EE +E E+ ++ +Y++ +++
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQ 1177
Score = 122 bits (306), Expect = 2e-27
Identities = 130/543 (23%), Positives = 236/543 (43%), Gaps = 36/543 (6%)
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK 640
++++ +E+E E + E+QE +E + R+E+ E L + E E +
Sbjct: 303 EQQLRRKQEEERREQQEERR-EQQERREQQEERREQQLRREQEERREQQL--RREQEEER 359
Query: 641 AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
+ E E R E E E++ + + R E + E + ++
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG--EEEEGDREEEEEKEGEGKEE 758
+++ EQE++ EQ H++ER ++ + +EE + EEE +R E+E ++ + K +
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 759 GEGE------EVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR-------G 805
E E ++E E +E+ ER++++ ++E+ E+ + + EEE + R
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEE---- 861
E+EE E EE + E+E E+ + E+EE + + E E + K E+E
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 862 ----GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
EE E E+ E E + EE E E ++ E+EE + + E E+
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659
Query: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
+ + EEE E + E EE E E E E E+ + + + + E E + +
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 978 EGEGEEEEGE---GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE-----GEVEGEVEGEE 1029
++EG+ E EE+ E E + + EE + +EEE+ + + E + E
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 1030 GEGEGEEEEGEEEGEEREKEGEGEENRRNR--EEEEEEEGKYQETGEEENERQDGEEYKK 1087
G E ER+ E + R R EEEE+E + ++ E E E Q EE ++
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 1088 VSK 1090
+ +
Sbjct: 840 LQR 842
Score = 122 bits (306), Expect = 2e-27
Identities = 155/697 (22%), Positives = 305/697 (43%), Gaps = 36/697 (5%)
Query: 452 ERNLQE---SVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSL 508
+R LQE E++L Q EE LL E E E +E + L L
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQ--LLGE---ERETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 509 NSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIF 568
+ + ++Q +++ + ++ L E + +E+ + Q + +
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 569 MTQPATT----IEAFSDEEVEIPEEKEGA---EDSKGNGIEEQEVEANEENVKVHGGRKE 621
+P +E EE E+ +E+E E K E++ EE + ++
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 622 KTEILSDDLTDKAE------VSEGKAKSVGEAEDGPEGRGDGTCEEGSS--GAEHWQDEE 673
+ E DL + E V + K G + D + S +H E+
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 674 REKGEKDKGRGEMER----PGEGEKELAEKEEWKKRDGEEQEQKE--REQGHQKERNQEM 727
+E+ + + R +R P E + E E++E K+RD + QE+K+ RE+ +K R QE
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 728 EEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGER-KKEERAGKEEK 786
+ EE +E E +E++ + +EE + +G + EE +R +++ER K K
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE 846
E++ E E++ + R + K E + E + REEE++ E E EEE+
Sbjct: 1395 EEQQLRCQEREQQLRQDR-DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 847 GEGEEEEGEGKGEEE--GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEG 904
+E + + EE+ E E + +E + + EEE + +E E+E E
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Query: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
E + E ++ + + + +E + +E G+ +D + + EEE + EE+
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 965 EGEEEGEGEGEEGEGEGEEEEGE-GEGEEEEGEEEGEEEGEGEEEGE-GEGEEEEEGEVE 1022
E + + EE + +E+E + E E++ +EG+++ E + + E E+ + E
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 1023 GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEE-EEEGKYQETGEEENERQD 1081
++ +E + + EEE + +ERE++ + +R+ REEE+ +EG+ Q+ +E +R+
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 1082 GEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQ 1118
EE +++ + + K+ + + ++ + +EQ
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Score = 122 bits (305), Expect = 3e-27
Identities = 143/538 (26%), Positives = 245/538 (45%), Gaps = 51/538 (9%)
Query: 577 EAFSDEEVEIPEEKEGAEDSKGNGIEEQEV--EANEENVKVHGGRKEKTEILSDDLTDKA 634
E +EE + E + E+ + +E QE+ E EE + R+E+ ++ ++
Sbjct: 258 EKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRRKQEEERR 315
Query: 635 EVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEERE---KGEKDKGRGEMERPGE 691
E E + + E E R E Q+E RE + E+++ R E + E
Sbjct: 316 EQQEERREQQERREQQEERREQQLRRE--------QEERREQQLRREQEEERREQQLRRE 367
Query: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE----- 746
E+E E++ +++ ++Q REQ ++E+ E+ E E++ RE
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 747 EEEEKEGEGKEEGEGEEVEGEREKEEG----------ERKKEERAGKEEKGEEEGDQGEG 796
E+EE+ E K E E E +RE+EE ER ++ER ++ K ++E ++ E
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 797 ----EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE 852
EEEE + E +E+ E E E + +R+EEEE ++ E++ E+E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE----RLQQRLRSEQQLRREQE 543
Query: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912
E + + EE E+E E + E+EE + + E E ++ + E EE E
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR-EEERRQQRLKREQEERLEQRL 602
Query: 913 EEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG-----EGE 967
+ EE E +EE E + EE E E + + E +EE + + E+ E + E
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG 1027
EE E + + E EEE E E EEE E+ E + + + E E + + +V
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR-QSKVYS 721
Query: 1028 EEGEGEGEEEEGEEEGEEREKEGE---GEENRRNREEEEEEEGK---YQETGEEENER 1079
+ EG+ E+E + R +E E EE R +R+++EEE+ + +Q EE++ER
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Score = 121 bits (304), Expect = 3e-27
Identities = 146/642 (22%), Positives = 275/642 (42%), Gaps = 68/642 (10%)
Query: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
+QK +Q E E D + EE +E E + KQ + + + ++ +
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
E E E +E + ++ E E+ +K R+E+ E L L + ++
Sbjct: 495 ERREQQERRE-------QQLRREQEERREQRLK----RQEEEERLQQRLRSEQQLRR--- 540
Query: 642 KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
+ E R E E + E+R K E+++ R ++ + E ++ K E
Sbjct: 541 -------EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Query: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
++R + +++E E+ Q+ER ++ + EE E ++ + EE+E+ + + E
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLK--REEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEK----------EEG 811
+E +R K E E ++ E+ K E EE +Q EEE+ + R K E
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 812 GEVEGGEV------EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
+ +V +EG+ R+E+EE+ E E + +EEE +++ E + + +
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 866 EGEEEGEEGEGE-------GEEEEGEGEGEEEGEGEG----EEEEGEGEGEEEGEGEGE- 913
+ EE+ E G E+ E + EE + E EEEE E + E E E
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 914 ---EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
EEE + + E ++ + E + + + E + + +++ W+ EEE
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 971 EGEGEEGEGEGE----EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE----EEGEVE 1022
+ +E + + EEE E + EE E E+E + EE + + EEE EE E
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 1023 GEVEGEEGEGEGEEEEGEEE---GEEREKEGEGEENRRNREE---EEEEEGKYQETGEEE 1076
E E + ++ + +EE GEE EK E ++ REE ++EEE +E E+
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 1077 NERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQ 1118
++ +Y+K +++ + + +K+ + + +E+
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Score = 118 bits (295), Expect = 4e-26
Identities = 114/445 (25%), Positives = 207/445 (46%), Gaps = 13/445 (2%)
Query: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
G+ ++E+ + DG+E ++R Q + R + + EEE G+ ++ +E E
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 752 EGEGKEEGEG--EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKE 809
EGE + E + E+ + +R EE R+++E +EE+ EE + ETE +E++
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 810 ----EGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
E E+ EE + +R E ++ EEEE E + E +EE + + EE +
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
E +EE EE + E +E E +EE E+++ E++ + EEE E + E
Sbjct: 270 ELQEE-EEQLRKLERQELRRERQEE-----EQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEE 985
++ E +EE E + + E E++ E EEE E + E E E E + E++
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 986 GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE-GEEGEGEGEEEEGEEEGE 1044
+ E + E++ E++ E + E ++ E + E E E E++ E+E
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQ 1104
E+ + E EE R + EEE E QE +++ +R EE ++ + + + +
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1105 KKSVTNTQGNGKEQRSKMPVQSKRL 1129
++ + Q +EQR K + +RL
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERL 528
Score = 117 bits (294), Expect = 5e-26
Identities = 147/567 (25%), Positives = 248/567 (43%), Gaps = 76/567 (13%)
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK 640
++++ +E+E E EQ ++ +E + R+E+TE + E K
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE--------RHEQERRK 473
Query: 641 AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
+ + E+ E R E E + E++E+ E+ R + ER + K E+E
Sbjct: 474 QQLKRDQEE--ERR-----ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE 760
++R EQ Q REQ ++E+ + EE E E E+ RE+EE ++ K E E
Sbjct: 527 RLQQRLRSEQ-QLRREQEERREQLLKREEEKRLEQ-ERREQRLKREQEERRDQLLKREEE 584
Query: 761 GEEVEGEREKEEG-----ERKKEERAGKEEKGEEEGDQGEGEEEETEG--RGEEKEEGGE 813
+ +RE+EE +R++ ER +EE+ E+ + E EEE + + EE+EE +
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 814 VE-GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE--------- 863
+ E +E + +R + EEE E E+ + E EE E+E E + E+ E
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 864 --EGEGEEEGEEGEGEGEEEEGEGE---GEEEGEGEGEEEEGEGEGEEEGEGEGEEEE-- 916
+ E E + + + + EG+ E+E + E E + + EE + +EEE
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 917 ----GEGKGEEEGEEGEGE-------GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE 965
+ + EE+ E G E+ E + E E ++ E + EEEE E
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE----ERQQREQRFLPEEEEKEQR 820
Query: 966 GEEEGEGEG-----EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE----GEEE 1016
+ E E EE E E + EEE+G +E +E +E+ + EE
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 1017 EEGEVEGEVEGEEGEGEG--------EEEEGEEEGEEREKEGEGEENRRNREEE---EEE 1065
E + + E +EEE E + EEREK E+ R+ REEE +EE
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 1066 EGKYQETGEEENERQDGEEYKKVSKIK 1092
E +E E+ ++ +Y+K K++
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQ 967
Score = 115 bits (287), Expect = 3e-25
Identities = 168/767 (21%), Positives = 316/767 (41%), Gaps = 98/767 (12%)
Query: 455 LQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTV---ESLGETTDILNMTHIMSLNSN 511
LQE + EQ L+Q EE + +E K + E L + + L
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 512 EKSLKLSPVQK--QKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI-- 567
E+ + +K QK++Q +GE + E + EE + +E + ++ +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 568 -FMTQPATTIEAFSDEEVEIPEEKEGA--EDSKGNGIEEQEVEANEENVKVHGGRKEKTE 624
+ Q E +EE + EE+E ++ + EE+E++ EE + + +
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 625 ILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684
L + E+ + + + + E PE R E E Q EE + +++
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREE---PEKRRRQERERQCREEEELQQEEEQLLREER--- 1128
Query: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 744
E R E E++ E+EE + +E+EQ RE+ +K R QE+E EE +EEE
Sbjct: 1129 EKRRRQELERQYREEEEVQ----QEEEQLLREEP-EKRRRQELERQYREEEELQQEEEQL 1183
Query: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGR 804
EE+EK + +E EE E +R+K + + E++ + E + + + +
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE------------EEEGEGEEE 852
G E E+ ++E ++ + + +++ + GE +E + E E EEE EE
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912
+ E K + + E + EE E + +E + + EE + E EE +E
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 913 EEE-----EGEGKGEEEG----EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963
EEE +G EEE +E E + +EE + ++ E + ++ EEE+
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 964 GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE-------- 1015
E + + EE + +E E + EE++ +E + EE+ E EE
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 1016 -----EEEGEV----------EGEVEGEEGEGEGEEEEGE-------------------- 1040
EEE ++ E E+ +E E + EEE +
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 1041 EEGEEREKEG-----EGEENRRNREEEE----EEEGKY----QETGEEENERQDGEEYKK 1087
E G++R ++ E E+ R+ REE++ E + K+ Q+ +E ER+ E+ ++
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 1088 VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGP 1134
+ + +G + + + + + +EQ+ + ++ L+ P
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650
Score = 103 bits (258), Expect = 7e-22
Identities = 154/688 (22%), Positives = 300/688 (43%), Gaps = 80/688 (11%)
Query: 456 QESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSL 515
+E V E++ + EEP+ +E E E E +L E+
Sbjct: 1143 EEEVQQEEEQLLREEPE---KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 516 KLSP-VQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMK------EGKACKQHVSQGIF 568
+ +Q+QK++Q + Q + L + ++ + + K E + +Q +
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 569 MTQPATTIEAFSDEEVEIPEEKEGA--EDSKGNGIEEQEVEANEENVKVHGGRK--EKTE 624
Q ++ E+ E E+E + + EE+++E E+ RK E+ +
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 625 ILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684
+L ++ +K E K E + +E Q+ +R+ E+
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQ---------LLQEREEQPLRRQERDRKFREE----- 1365
Query: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEE--- 741
E+ +G K L E++ ++++ E + KE +Q +ER Q++ + + + E E++
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 742 -EGDREEEEEKEGEGKEEGEGEEVEGERE-KEEGERK-KEERAGKEEKGEEEGDQGEGE- 797
E DR+ EE++ ++E E + +E E++ ++E RK +EE +E+ E++ + E +
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 798 ---EEETEGRGEEKEE--------GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE 846
EEE + R +E++ E E +EE + ++ + +EE+ +E
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Query: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG------EEEEGEGEGEE----EGEGEGE 896
G+ ++ + K EE + + EE + E EE++ + +E E E +
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605
Query: 897 EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE----EEEGEGEGEDGEGEGEEEE 952
+EG+ + +E + + E+E + EE + E + EEE + ++ E + +
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665
Query: 953 GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
EEE+ EGEE+ + +E + + EEE + +E E + EE+ +E E +
Sbjct: 1666 DRKFREEEQLLQEGEEQ-QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Query: 1013 GEEEEEGEVEGEVEG-----------EEGEGEGEEEEGEEEGEEREKEGEGEEN-RRNRE 1060
EEE+ E E E EE + E EE + +ER+++ EE R+ RE
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 1061 EE----EEEEGKYQETGEEENERQDGEE 1084
E+ +E + K++ EEE RQ+ EE
Sbjct: 1785 EQQLRSQESDRKFR---EEEQLRQEREE 1809
Score = 103 bits (256), Expect = 1e-21
Identities = 112/486 (23%), Positives = 224/486 (46%), Gaps = 31/486 (6%)
Query: 670 QDEEREKGEKD-KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEME 728
++E++ + E+ K R E + E E++ ++E ++ EE++Q R++ +K R QE+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 729 EGGEEEHGEGEEEEGDREE------EEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG 782
E EE++ R++ +EE++ +E G+ + +R+ E E+ ++ER
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE 1569
Query: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
++ +E + EE++ + +E++ + + +EG+ + +E + E+E+
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 843 EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 902
E EE + +E + K EE + +E ++ + + + E EE+ EGEE++
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE---EEQLLQEGEEQQLRR 1686
Query: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962
+ + E E++ + E + + E + +E E + + E +E E E +E
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Query: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022
EEE E + +E EEE+ +E EE+ +E + + EEE+ E
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Query: 1023 GE---VEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEE---------EEEGKYQ 1070
E + ++ +G+ EE + + EE+E+ E +R+ R EE+ EE+ +Q
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866
Query: 1071 ETGEEENERQDGEEYKKVSKIKGSVK-------YGKHKTYQKKSVTNTQGNGKEQRSKMP 1123
E EE+ RQ+ E + I+ K G+ K+ + K G Q + +P
Sbjct: 1867 E--EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVP 1924
Query: 1124 VQSKRL 1129
V+S L
Sbjct: 1925 VRSSPL 1930
Score = 102 bits (254), Expect = 2e-21
Identities = 116/574 (20%), Positives = 257/574 (44%), Gaps = 24/574 (4%)
Query: 522 KQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD 581
+++++Q + +D E + + + ++E + ++ + F+ + +
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
+++ +++ E+ + +E++ + EE +V +E+ L ++ ++ + +
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF-----LEEEQQLRQERH 1460
Query: 642 KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEER-EKGEKDKGRGEME-RPGEGEKELAEK 699
+ E E + R + + ++E++ + E+D+ E E R E E++ E+
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Query: 700 EEWKKRDG-------EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752
E+ R EEQ+ + +E+G Q+ ++++ + EEE E EE +E
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD-RKFREEEQLRQEREEQQLSRQERDR 1579
Query: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812
EE + E ER+ E E++ + G+++ +E + +E+ + R E++
Sbjct: 1580 KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE 872
E + +EE R +E E+ + + + EEE +E E + +E + EEE +
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 873 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE--GEGKGEEEGEEGEG 930
E E + +EE + +E E + EE+ E E+E+ + + + EE +
Sbjct: 1700 LRRQERERK----FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 931 EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990
E EE + ++ + + EEE + E EE + +E EE + E EE +
Sbjct: 1756 RPEREEQQLRRQERDRKFREEE-QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 991 EEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE--GEEGEGEGEEEEGEEEGEEREK 1048
++ +G+ EEE EE E +E + + E + +E E+E +EE ++R +
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 1049 EGEGEENRRNREEEEEEEGKYQETGEEENERQDG 1082
E E + + +++EE ++++ GE +++ G
Sbjct: 1875 ERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
Score = 89.7 bits (221), Expect = 1e-17
Identities = 98/409 (23%), Positives = 183/409 (44%), Gaps = 29/409 (7%)
Query: 746 EEEEEKEGEGKEE--GEGEEVEGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEEE 800
+EE+ +GKE + + E +R E +R+ EE G ++++ E+E + EGEE+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 801 TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE 860
EK+E +E+ +R +EE + +E + E EE EEE+ +
Sbjct: 156 ------EKQE-------RLEQRDRQRRDEELWRQRQEWQ---EREERRAEEEQLQSCKGH 199
Query: 861 EGEEGEGEEEGEEGE-----GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
E EE EE+ E +G EE+ + E + EEEE E E + EE+
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 916 EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE 975
E + + + E E E + + E + E + EE++ + E++ + EEE + E
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG-EVEGEVEGEEGEGEG 1034
E + E E + E E++ E EE E + E E E E+ E E E E +
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 1035 EEEEGEEEGEEREKEGEGEENRRNREE--EEEEEGKYQETGEEENERQDGEEYKKVSKIK 1092
E++ E+ RE++ E+ R ++ E++ + Q+ E+ R++ EE + K +
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 1093 GSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFW 1141
+ + K Q++ + + +R + + ++L ++ ++ W
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Score = 86.3 bits (212), Expect = 2e-16
Identities = 106/495 (21%), Positives = 210/495 (42%), Gaps = 42/495 (8%)
Query: 548 EEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVE 607
EE ++++ + K + + + + + + EE++ + EQE+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Query: 608 ANE-------ENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCE 660
+ E E ++H ++++ + + + E + + + E E
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE 1569
Query: 661 EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQ 720
+ S E +D + E+ R E ER +++ ++E +++ +E+++K RE
Sbjct: 1570 QQLSRQE--RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780
+ +E + +E + EEE + +E+E + + + + + E E+ +EGE ++ R
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEE-PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Query: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
++ K EE Q +E E + EE+ ++ E+E + REEE+ E E+E+
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQ----QLRRQELE--RKFREEEQLRQETEQEQL 1740
Query: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
+E + EEE + E EE + +E EEE+
Sbjct: 1741 RRQERYRKILEEE---------------------QLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE 960
E EE+ + +E + K EE E+ E EE++ + DG+ EEE+ + E +E+
Sbjct: 1780 RQEREEQ---QLRSQESDRKFREE-EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 961 EGEGEGEEEGEGEGEEGEGE-GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
E + + E + E EE E EEE+ + E EE + +EE+
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895
Query: 1020 EVEGEVEGEEGEGEG 1034
GE++ +EG+G G
Sbjct: 1896 RQVGEIKSQEGKGHG 1910
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 137 bits (346), Expect = 5e-32
Identities = 139/538 (25%), Positives = 204/538 (37%), Gaps = 90/538 (16%)
Query: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEERE-KGEKDKGRGEMERPG 690
D+ + E +K G G + +EG SG E + + + +G + G + E
Sbjct: 87 DREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSA 146
Query: 691 EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750
E L +D +E E E H R+ GE++ GE EEEE + EEE
Sbjct: 147 EHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEAS 206
Query: 751 KE---------GEGKEEGE----GEEVEGEREKEEGERKKEERAGKEEKGEEEGD----- 792
E G G EE E G G + +G + ++ ++ +++ D
Sbjct: 207 TEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEY 266
Query: 793 -------QGEGEEEETE-------------GRGEEKEEGGEVE-----GGEVEEGKGERE 827
QG G EE+ + R E+++ + + G + + R+
Sbjct: 267 RHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRK 326
Query: 828 EEEEEGEGEEE--------EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE---- 875
EE E GE +G +EEE E E +G + G +EE EE E
Sbjct: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQ 386
Query: 876 ----GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE 931
+ G EE+ + E + E E EE E G + +
Sbjct: 387 FGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAE-LGHQAPSHRQSH 445
Query: 932 GEEEEGEGEG------------------------EDGEGEGEEEEGEWEGEEEEGEGEGE 967
+EE G G+ +D E E E+EE EE++ E
Sbjct: 446 QDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQG 505
Query: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG 1027
E+G G + E EE+E EG G EEE EE+ E EEE E E EE EV +
Sbjct: 506 EKGTHHGSRDQ-EDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSP 564
Query: 1028 EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEY 1085
+ E E EEEEG EE E R N +R EE +E+GE+ QD +EY
Sbjct: 565 DHSEEEEEEEEGLEEDEPRFTI---IPNPLDRREEAGGASSEEESGEDTGP-QDAQEY 618
Score = 108 bits (271), Expect = 2e-23
Identities = 114/453 (25%), Positives = 175/453 (38%), Gaps = 59/453 (13%)
Query: 594 EDSKGNGIEEQEVEANEENVKV-HGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652
ED +G EE+E E E + + H + + +D +VS+G GP
Sbjct: 188 EDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEED----EDVSDG------HHHHGPS 237
Query: 653 GRGDGTCEEGSSGAEHWQDEE--------REKGEKDKGRGEME----RPGEGEKELAEKE 700
R G E+ + D++ R + + +G G E G ++ + +
Sbjct: 238 HRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRH 297
Query: 701 EWKKRDGEEQEQKEREQGHQKERNQ-------EMEEGGEEEHGEGEEEEGDREEEEEKEG 753
+ D + + E GHQ R+Q E G H +G R+EEE+++
Sbjct: 298 RSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDV 357
Query: 754 EGKEEGEGEE------VEGEREKEE-GERKKEERAGKEEKGEEEGDQGEGEEEETEGRGE 806
+ +G + V+ E E+EE + A + +G + ++ +E +TE
Sbjct: 358 STERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHH 417
Query: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG------KGEE 860
E EV G + + +EE G G+ + G +
Sbjct: 418 HHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHL 477
Query: 861 EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG---EGEEEEG 917
++ E E+E EE G EE++ E E+G G ++ + E EEEG G EEEE
Sbjct: 478 RKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEE 537
Query: 918 EGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG------- 970
E K EEE EE E E EE E EEEE EEEEG E E
Sbjct: 538 EDKEEEEEEEDE-ERREERAEVGAPLSPDHSEEEE-----EEEEGLEEDEPRFTIIPNPL 591
Query: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEG 1003
+ E G EEE GE G ++ E + G
Sbjct: 592 DRREEAGGASSEEESGEDTGPQDAQEYGNYQPG 624
Score = 106 bits (265), Expect = 1e-22
Identities = 112/463 (24%), Positives = 175/463 (37%), Gaps = 95/463 (20%)
Query: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK 640
+EE E EE+E A G+ +EE+ +D++D
Sbjct: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEED---------------EDVSD-------- 229
Query: 641 AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--------REKGEKDKGRG----EMER 688
G GP R G E+ + D++ R + + +G G E
Sbjct: 230 ----GHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVS 285
Query: 689 PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ-------EMEEGGEEEHGEGEEE 741
G ++ + + + D + + E GHQ R+Q E G H
Sbjct: 286 DGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRH 345
Query: 742 EGDREEEEEKEGEGKEEGEGEE------VEGEREKEE-GERKKEERAGKEEKGEEEGDQG 794
+G R+EEE+++ + +G + V+ E E+EE + A + +G + ++
Sbjct: 346 QGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEED 405
Query: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE----------- 843
+E +TE E EV G + + +EE G G+
Sbjct: 406 FQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHP 465
Query: 844 -------------EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE 890
+++ E E+E+ E G E E+ E E+GE+G G ++ + E EEE
Sbjct: 466 PGHTVVKDRSHLRKDDSEEEKEKEEDPGSHE-EDDESSEQGEKGTHHGSRDQEDEEDEEE 524
Query: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG------EGEGEEEEGEGEGED- 943
G G +E E EEE + E EEEE E + EE E G E EEEE EG ED
Sbjct: 525 GHGLSLNQE---EEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDE 581
Query: 944 -------GEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979
+ EE G EEE GE G ++ + G G
Sbjct: 582 PRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPG 624
Score = 91.3 bits (225), Expect = 5e-18
Identities = 100/478 (20%), Positives = 179/478 (37%), Gaps = 75/478 (15%)
Query: 649 DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKD--KGRGEMERPGEGEKELAEKEEWKKRD 706
D P+ D + E G W +REK ++D K G + PG ++ +E +
Sbjct: 66 DHPDENKDVSTENGH---HFWSHPDREKEDEDVSKEYGHL-LPGHRSQDHKVGDEGVSGE 121
Query: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEG 766
E + +GH+ +++ E+ E H ++E+E E E G
Sbjct: 122 EVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHG 181
Query: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826
R + G++++GEEE EEEE EE+EE G + +G
Sbjct: 182 HRGHD----------GEDDEGEEE------EEEE-----EEEEEASTEYGHQAHRHRGHG 220
Query: 827 EEEEEE-GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
EE+E+ +G G +G E+++ +++ ++ + +++ E + +G
Sbjct: 221 SEEDEDVSDGHHHHGPSHRHQGHEEDDD-----DDDDDDDDDDDDDVSIEYRHQAHRHQG 275
Query: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
G EE E + E ++ + + E G + + + E E GE
Sbjct: 276 HGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGE 335
Query: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE-----GE 1000
+ +G +E EE E E +G + G +EEE EEE G
Sbjct: 336 HHHHVPDHRHQGHRDE------EEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGH 389
Query: 1001 EEGEGEEEGEGEGEEEEEGEVEGEV-----------EGEEGEGE-GEEEEGEEEGEEREK 1048
+ G EE+ + E + EV E EE E G + + + E+
Sbjct: 390 YVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEE 449
Query: 1049 EGEGE------------------ENRRNREEEEEEE-GKYQETGEEENERQDGEEYKK 1087
G G+ + R+++ EEE K ++ G E + + E+ +K
Sbjct: 450 TGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEK 507
Score = 77.4 bits (189), Expect = 7e-14
Identities = 67/280 (23%), Positives = 114/280 (40%), Gaps = 27/280 (9%)
Query: 826 REEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE----EGEEGEGEEEGEEGEGEGEEE 881
R+ +E + E G + E+E+ + E G + + G+EG GEE
Sbjct: 65 RDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVS-GEEV 123
Query: 882 EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGE- 940
E G+ G G G E+ E E + E E E E
Sbjct: 124 FAEHGGQARGH--------RGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHH 175
Query: 941 -----GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG-EEEEGEGEGEEEE 994
G G +GE++EGE E EEEE E E E + G G EE+E +G
Sbjct: 176 HILRHGHRGH-DGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHH 234
Query: 995 G---EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGE 1051
G +G EE + +++ + + +++++ +E + +G G EE+ E+ +
Sbjct: 235 GPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEED-EDVSDGHHHRDP 293
Query: 1052 GEENRRNREEEEEEEGKYQETGEEENERQD--GEEYKKVS 1089
+R + E++ +++ E G + + QD EE + VS
Sbjct: 294 SHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVS 333
Score = 64.3 bits (155), Expect = 6e-10
Identities = 72/293 (24%), Positives = 123/293 (41%), Gaps = 32/293 (10%)
Query: 543 DSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIP-EEKEGAEDSKGNGI 601
D +E E++S + + QHV G+ E +EE+ + + +G+
Sbjct: 350 DEEEDEDVSTERWHQG-PQHVHHGL-------VDEEEEEEEITVQFGHYVASHQPRGHKS 401
Query: 602 EEQEVEANEENVKV-----HGGRKEKTEILSDDLTDKA----------EVSEGKAKSVGE 646
+E++ + +E +V H +E+ E +S +L +A E G+ S+ E
Sbjct: 402 DEEDFQ-DEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKE 460
Query: 647 AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRD 706
P G T + S +D+ E+ EK++ G E E ++ + RD
Sbjct: 461 MSHHPPGH---TVVKDRSHLR--KDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRD 515
Query: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEG 766
E++E + E+GH NQE EE ++E E EE+E REE E + EE E
Sbjct: 516 QEDEE--DEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEE 573
Query: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
E EE E + ++ EE G EE + ++ +E G + G +
Sbjct: 574 EEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQEYGNYQPGSL 626
Score = 39.7 bits (91), Expect = 0.017
Identities = 32/139 (23%), Positives = 50/139 (35%), Gaps = 3/139 (2%)
Query: 955 WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014
W + E E E + G G + + G+ E GEE E G G G
Sbjct: 83 WSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGD---EGVSGEEVFAEHGGQARGHRGHGS 139
Query: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGE 1074
E+ E E ++E E+E E + + E++EG+ +E E
Sbjct: 140 EDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEE 199
Query: 1075 EENERQDGEEYKKVSKIKG 1093
EE E E + + +G
Sbjct: 200 EEEEEASTEYGHQAHRHRG 218
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 136 bits (342), Expect = 1e-31
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 58 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 116
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 117 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 175
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 176 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 235
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 236 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 295
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 296 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 353
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 354 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 384
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 82 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 140
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 141 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 198
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 199 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 258
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 259 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 316
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 317 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 375
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 376 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 434
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 435 VSSGGQHTVL 444
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 165 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 222
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 281
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 282 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 339
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 340 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 399
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 400 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 448
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 136 bits (342), Expect = 1e-31
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 1e-31
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 1e-31
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 136 bits (342), Expect = 1e-31
Identities = 111/334 (33%), Positives = 162/334 (48%), Gaps = 29/334 (8%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
H + T + G + GQLGLG K + ++ PE V A G HT+ ++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSI-PEDVVQAEAGGMHTVCLSKS 85
Query: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
G VY+ G N+EG LG DT + V + K+ Q+SAG + +AALT+DGR+F+WG
Sbjct: 86 GQVYSFGCNDEGALGR-DTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 166 D--NSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKL 222
++ G IGL + + VP QV + PV ++ G H +T DG+LY G E G+L
Sbjct: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204
Query: 223 GLPNQLLGNHRTPQLVSE--IPEKVI-------------QVACGGEHTVVLT-ENAVYTF 266
G +L N Q + +P+ V+ CG T ++ E VY F
Sbjct: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264
Query: 267 GLGQFGQLGL-GTFLFETSEPKVIENIRDQTISYI--SCGENHTALITDIGLMYTFGDGR 323
GL + QLG GT P+ + + ++ T S++ S G++HT + G Y+ G
Sbjct: 265 GLSNYHQLGTPGT--ESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAE 322
Query: 324 HGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACG 357
+G+LGLG E IPTL S V VACG
Sbjct: 323 YGRLGLG-EGAEEKSIPTLISRLP--AVSSVACG 353
Score = 95.9 bits (237), Expect = 2e-19
Identities = 89/370 (24%), Positives = 161/370 (43%), Gaps = 31/370 (8%)
Query: 18 GKSKFAENNPGKFWFKNDVPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISK 77
G++ P DV V G H+ ++ + ++Y FG N+ G LG + S+
Sbjct: 51 GENVMERKKPALVSIPEDV-VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSE 109
Query: 78 PTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGG--NNEGQLGLGDTEERNTFHVISF 135
K EKV + G +HT T+ G V+ G +N G +GL + +++ V
Sbjct: 110 MVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV--Q 167
Query: 136 FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI-----------GLKNVSNVCVPQ 184
+ + ++++G++ LT DG L+ G +GQ+ G + + + VP+
Sbjct: 168 VQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 185 QVTIGKPVSW-------ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQL 237
V + S CG Y + ++ +G +Y FG +LG P + PQ
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPG--TESCFIPQN 285
Query: 238 VSEIPEKV---IQVACGGEHTVVL-TENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
++ + + G HTV + +E Y+ G ++G+LGLG E S P +I +
Sbjct: 286 LTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL- 344
Query: 294 DQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKL 353
+S ++CG + +T G ++ +G G + +LG G + + + +V
Sbjct: 345 -PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLS 403
Query: 354 VACGGCHMVV 363
V+ GG H V+
Sbjct: 404 VSSGGQHTVL 413
Score = 75.9 bits (185), Expect = 2e-13
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 54/296 (18%)
Query: 8 MPDSGAVFTFGKSKFAENN-------PGK-----FWFKNDVPV-HLSCGDEHSAVVTGNN 54
+ D G VF +G F +NN P K + DVPV ++ G++H ++T +
Sbjct: 134 LTDDGRVFLWGS--FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 55 KLYMFGSNNWGQLGL--------GSKSAISK---PTCVKALKPE------KVKLAACGRN 97
LY G GQLG G + + + P CV LK + + A CG
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM-LKSRGSRGHVRFQDAFCGAY 250
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTF---HVISFFTSEHKIKQLSAGSNTSAA 154
T + G+VY G +N QLG TE + F ++ SF S S G + +
Sbjct: 251 FTFAISHEGHVYGFGLSNYHQLGTPGTE--SCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308
Query: 155 LTEDGRLFMWGDNSEGQIGL-KNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
+ +G+ + G G++GL + +P ++ VS ++CG VT DG ++
Sbjct: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368
Query: 214 FGEPENGKLGL--------PNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTEN 261
+G N +LG P +++G QL + + V+ V+ GG+HTV+L ++
Sbjct: 369 WGMGTNYQLGTGQDEDAWSPVEMMGK----QLENRV---VLSVSSGGQHTVLLVKD 417
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 133 bits (334), Expect = 1e-30
Identities = 155/643 (24%), Positives = 282/643 (43%), Gaps = 69/643 (10%)
Query: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
++Q+ Q++ G+ ++ + D+ D +E+ E+ +QGI + ++
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLE-------AQGIKADRETVAVKPTE 85
Query: 581 DEEVEIP---EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS-----DDLTD 632
+ E E ++K+G + K + + E +++ K K K E+ S DD
Sbjct: 86 NNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNK 145
Query: 633 KAEVSEGKAKSVGEAEDGPEGRGDGTCE---------EGSSGAEHWQDEEREKGEKDKGR 683
+ ++GKA+ + DG E D + + G SG E + + KG+K +
Sbjct: 146 LPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK---K 202
Query: 684 GEMERPGEGEKELAEKEE---------WKKRDGEEQEQKEREQGHQKERN-QEMEEGGEE 733
+ +PG + E ++ KK + +E+E+K+R++ K R +E EE
Sbjct: 203 NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETG 262
Query: 734 EHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ 793
+ + +++E R+ EEE G E + E +++ G ++K +++ +
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
Query: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
GE EE+E E +K+ + ++E + +EEEE + EEEE EE E + +E
Sbjct: 323 GEKEEKEKE----KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378
Query: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE------EEEGEGEGEEE 907
E + E+E E + ++E E E +E + + + E E + +G ++
Sbjct: 379 EE-RLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKD 437
Query: 908 GEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE-----GEGEDGEGEGEEEEGEWEGEEEEG 962
+ + K ++ ++ E + E E E G E EE E EEEE
Sbjct: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEE- 496
Query: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022
+ E+ G + E + E E+ EG E +E EEE E EEE E + E EEE E E
Sbjct: 497 --DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEE 554
Query: 1023 GEVEGEEGEGEGEEEEGEEE-GEEREKEGEGE---ENRRNREEEEEEEGKYQETGEEENE 1078
GE EG EG+ E E+ E++ G+ +K+ E ++ + +++ +E + + + E
Sbjct: 555 GESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614
Query: 1079 RQDGEEYKKVSKIK---------GSVKYGKHKTYQKKSVTNTQ 1112
++ E K V+ K G V GK K K T+ Q
Sbjct: 615 KRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQ 657
Score = 98.2 bits (243), Expect = 4e-20
Identities = 154/652 (23%), Positives = 282/652 (43%), Gaps = 106/652 (16%)
Query: 521 QKQKKQQ-TIGELTQDTALTENDDSDEYEEMSEMK-EGKACKQHVSQGIFMTQPATTIEA 578
QK K + T ++ D E + + +E K +GK K+ Q +E
Sbjct: 5 QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64
Query: 579 FSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSE 638
S E I ++E K E+E + ++ K G+K K + D+ +++ E +
Sbjct: 65 LSLEAQGIKADRETVA-VKPTENNEEEFTSKDKKKK---GQKGKKQSFDDNDSEELEDKD 120
Query: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698
K+K + + E SG++ D+ + +K KG+ +
Sbjct: 121 SKSKKTAKPK-----------VEMYSGSDD-DDDFNKLPKKAKGKAQKSN---------- 158
Query: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEE 758
KK DG E+++ ++ ++ R E G+E + +G ++ ++ K G E
Sbjct: 159 ----KKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIES 214
Query: 759 GEGEE---------VEGEREKEEGERKK--EERAG----KEEKGEEEGDQGEGEEEETEG 803
G ++ + + EK+E ERKK EE+A KE++ E G + + +++E++
Sbjct: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQR 274
Query: 804 RGEEKEEGGEVEGGEVEEGK-GEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862
+ EE+ +V V+ G EE+ E E++ EG++++ + ++++GE K E+E
Sbjct: 275 KFEEETVKSKVT---VDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE-KEEKEK 330
Query: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
E+ +G + +E + +EE E + EEE + EE E + +EEE + E
Sbjct: 331 EKKKGPSKATVKA----MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE---RLE 383
Query: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE 982
+E E + + E+E E ++G+ + + E E + + +G
Sbjct: 384 QEKRERKKQKEKERKERLKKEGKLLTKSQR------------EARARAEATLKLLQAQGV 431
Query: 983 EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG-EEGEGE-------- 1033
E + ++ E ++ + ++ E + E E E+ VE E+G E
Sbjct: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESK-EVSESMELCAAVEVMEQGVPEKEETPPPV 490
Query: 1034 --GEEEEGEEEG----------EEREK-EG-----EGEENRRNREEEEEEEGKYQETGEE 1075
EEE+ E+ G EE EK EG E +EN EEEEEEE + +E+ EE
Sbjct: 491 EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEE 550
Query: 1076 ENER------QDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSK 1121
E E + EE +KVS K S K K K+ ++++ + + R+K
Sbjct: 551 EEEEGESEGSEGDEEDEKVSDEKDSGK-TLDKKPSKEMSSDSEYDSDDDRTK 601
Score = 79.3 bits (194), Expect = 2e-14
Identities = 93/465 (20%), Positives = 206/465 (44%), Gaps = 66/465 (14%)
Query: 726 EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE 785
E+E G + E ++ +G +++E++K+ +++ E E E + + +E A K
Sbjct: 25 EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT 84
Query: 786 KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE 845
+ EE + ++++ +G+ +K+ + + E+E+ K + ++ + + E G +++
Sbjct: 85 ENNEE--EFTSKDKKKKGQKGKKQSFDDNDSEELED-KDSKSKKTAKPKVEMYSGSDDDD 141
Query: 846 EGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE---GEGEGEEEGEGEGEEEEGEG 902
+ ++ +GK ++ ++ +G EE E+ + +E GE +E + + +G+
Sbjct: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQK 201
Query: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962
+ ++ G E E + + + E+ E E + + +EE+ + +E+
Sbjct: 202 KNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK----KRDEEKAKLRKLKEKE 257
Query: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEG-----EEEGEEEGEGEEEGEGEGEEEE 1017
E E ++ + + +E + + EEE + + + G EE+ E E++ EG+ ++++
Sbjct: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317
Query: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEG----------------EGEENRRNREE 1061
+ + +GE +EE E+ +K+G + EE R+ REE
Sbjct: 318 KKKKKGE---------------KEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 1062 E------EEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKK--------S 1107
E EE E K +E E E+++ ++ K+ + + K GK T ++ +
Sbjct: 363 EERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEAT 422
Query: 1108 VTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLPHYLELK 1152
+ Q G E SK + KR + K +P LE K
Sbjct: 423 LKLLQAQGVEVPSKDSLPKKRPIYEDKKRKK------IPQQLESK 461
Score = 72.0 bits (175), Expect = 3e-12
Identities = 76/413 (18%), Positives = 184/413 (44%), Gaps = 65/413 (15%)
Query: 782 GKEEKGEEEGDQGEGEE-----EETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGE 836
GK++K + E + + E EG G KE+ + G+ ++ K +++ +E++ E
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
Query: 837 EEE-------------------GEGEEEEGEGEEEEGEG-KGEEEGEEGEGEEEGEEGEG 876
EE E EEE ++++ +G KG+++ + EE E+ +
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 877 E--------------GEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
+ ++++ + ++ +G+ ++ + +G EE E ++ + +
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 923 EEGEEGEGEGE---EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEG 979
GE G+ E +G+ + + + E G E+++ + + + + E+ E
Sbjct: 182 SSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG---NEDDDASFKIKTVAQKKAEKKER 238
Query: 980 EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE-EEGEVEGEVEGEEGEGEGEEE- 1037
E ++ + E + E+E E G+ ++ + E + + EE V+ +V + G EE
Sbjct: 239 ERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298
Query: 1038 -------EGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETG----------EEENERQ 1080
E + EG++++K+ + ++ + +E+E+++G + T +EE ERQ
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358
Query: 1081 DGEEYKKVSKIKG-SVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKN 1132
EE +++ +++ K + + +++ + KE++ ++ + K L K+
Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKS 411
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 131 bits (330), Expect = 3e-30
Identities = 133/480 (27%), Positives = 214/480 (44%), Gaps = 62/480 (12%)
Query: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
P T +VE P+ K ++ + VE E KV + E E L+ +T
Sbjct: 429 PITISSKIQKPKVEAPKLK----------VQHKFVEEIIEETKVEDEKSEMEEALTA-IT 477
Query: 632 DKAEVS--EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689
++ VS E K ++ E E+ PE ++E K K +
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAE---------------EEEVAAKKSPVKATAPEVKE 522
Query: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
EGEKE EE+ Q+E E+ + ++ + EEGG E+ G E+EEG++EE
Sbjct: 523 EEGEKE------------EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEE-- 568
Query: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE-KGEEEGDQGEGEEEETEGRGEEK 808
GE + E EGEE E + EK+ E K EE A KEE + + ++ E + E+
Sbjct: 569 ---GETEAEAEGEEAEAKEEKKV-EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 624
Query: 809 EEGGEVEGGEVEE-GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
+ V VEE GK + E +G+ + EE +G+ + EE+ +
Sbjct: 625 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVP 683
Query: 868 EEEGEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
+ EE + + E +GE + EEE E E +EE + EE+ + E+++ E +EE
Sbjct: 684 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 743
Query: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
+ ++ + EG+ + E E E+ GEG EEEG +G +G +
Sbjct: 744 AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK------ 797
Query: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER 1046
E GE EG+EE E E + +G G EEE+G V ++ +E++G ++ EE+
Sbjct: 798 --EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD----LSPADEKKGGDKSEEK 851
Score = 127 bits (319), Expect = 6e-29
Identities = 140/441 (31%), Positives = 199/441 (45%), Gaps = 82/441 (18%)
Query: 732 EEEHGEGEEEEGDREEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789
E+E E EE EE + E KE E +E E E E+EE KK + +E
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE 522
Query: 790 EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE-EEEGE 848
E EGE+EE EG+ EE+EE + + EEG E+E E+ EGE+EEGE E E EGE
Sbjct: 523 E----EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 849 GEEEEGEGKGEEEGEEGEGEEE---------GEEGEGEGEEEEGEGEGEEEGEGEGEEEE 899
E + E K EE+ EE +EE E+ + + E +G+ EE+
Sbjct: 579 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 638
Query: 900 G-----EGEGEEEGEGEGEEEEGEGKG---------EEEGEEGEGEGEEEEGEGEGEDGE 945
G + EE+G+ + E KG EE+ + + EE + + E G+
Sbjct: 639 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 698
Query: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE------------ 993
GE +EEE E+E E EE+ E + E+ + E+++ E +EE
Sbjct: 699 GEQKEEE-----EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 753
Query: 994 ------EGEEEG---EEEGEGEEEGEGEGEEEEEGE-------------VEGEVEGEEGE 1031
E +EEG ++E E E+ G GEG EEEG V GEVEG+
Sbjct: 754 KVHLEKETKEEGKPLQQEKEKEKAG-GEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK--- 809
Query: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKI 1091
E E+E +E+G RE+E N + +E++G G++ E+ K V KI
Sbjct: 810 -EEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG-----GDKSEEKV--VVTKTVEKI 861
Query: 1092 KGSVKYGKHKTYQKKSVTNTQ 1112
G K Y KSVT TQ
Sbjct: 862 TSEGGDGATK-YITKSVTVTQ 881
Score = 107 bits (268), Expect = 5e-23
Identities = 114/376 (30%), Positives = 171/376 (45%), Gaps = 62/376 (16%)
Query: 797 EEEETEGRGEEKEEG-----GEVEGGEVEEGKGEREEEEEEGEGEEEEGEG--------- 842
EE + E E EE E+ EE K EE+EEE E EEEE
Sbjct: 458 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATA 517
Query: 843 -EEEEGEGEEEEGEGKGEEEGEEGEG------EEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
E +E EGE+EE EG+ EEE EE EG EE G E EG E+EEGE +EEGE E
Sbjct: 518 PEVKEEEGEKEEEEGQ-EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE---QEEGETEA 573
Query: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGE-------EEGEEGEGEGEEEEGEGEG------- 941
E E E E +EE + E + EE K E E+ E+ + + E +G
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 633
Query: 942 ---EDGEGEGEEEEGEWEGEEEEGEGEGEEEG---------EGEGEEGEGEGEEEEGEGE 989
E G+ + E +G+ + EE+G E + + + EE + +
Sbjct: 634 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 693
Query: 990 GEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE-----EGE 1044
E +GE++ EEE E +E + E E++E + + E ++ E +EE E +
Sbjct: 694 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 753
Query: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE--YKKVSKIKGSVKYGKHKT 1102
+ E E +E + ++E+E+E E G EE G + K+ + G V+ GK +
Sbjct: 754 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE-GKEEV 812
Query: 1103 YQKKSVTNTQGNGKEQ 1118
Q+ T +G+G+E+
Sbjct: 813 EQE---TKEKGSGREE 825
Score = 101 bits (251), Expect = 5e-21
Identities = 101/348 (29%), Positives = 153/348 (43%), Gaps = 30/348 (8%)
Query: 819 VEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG 878
VEE E + E+E+ E EE EE +EE + EE+ EE E EEE E +
Sbjct: 453 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE--EVAAKK 510
Query: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938
+ +E EGE EEEEG+ E EEE EG ++ EG E+EG + EGE+EEGE
Sbjct: 511 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 570
Query: 939 GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE---------EEEGEGE 989
E E EGE E + E + EE+ E +EE + + + E EE+G+
Sbjct: 571 TEAE-AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 629
Query: 990 GEEEEGEEEG---------EEEGEG-------EEEGEGEGEEE--EEGEVEGEVEGEEGE 1031
+ EE+G EE+G+ EE+G+ + EE + E
Sbjct: 630 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 689
Query: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKI 1091
+ + E G+ E +E E++ E + + E++EE+ K ++ E +V I
Sbjct: 690 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 749
Query: 1092 KGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKK 1139
SVK K +++ Q KE+ + G GS+K
Sbjct: 750 TKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 797
Score = 85.5 bits (210), Expect = 3e-16
Identities = 109/380 (28%), Positives = 165/380 (43%), Gaps = 61/380 (16%)
Query: 512 EKSLKLSPVQKQKKQ--QTIGELTQDTALTENDD------SDEYEEMSEMKEGKACKQHV 563
E + K SPV+ + + GE ++ E ++ SD+ EE KEG + K+
Sbjct: 505 EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 564
Query: 564 SQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKT 623
Q EE E E EG E EE++VE E V K
Sbjct: 565 EQ----------------EEGETEAEAEGEE---AEAKEEKKVEEKSEEVAT------KE 599
Query: 624 EILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEE-GSSGAEHWQDEEREKGE---- 678
E+++D +K E ++ E G EE G S EE+ K
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 659
Query: 679 --KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ-EMEEGGEEEH 735
++KG+ + + EK A+ K E + + E +G QKE + E++E +EE
Sbjct: 660 PVEEKGKSPVSKSPVEEK--AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 717
Query: 736 GEGEEEE-GDREEEEEKEGEGKEEGEGE--------EVEGERE-KEEGERKKEERAGKEE 785
E +EE+ D E+++ E KEE E +V E+E KEEG+ ++E+ KE+
Sbjct: 718 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE-KEK 776
Query: 786 KGEEEGDQGEGEEEETEG-RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844
G E G + EG ++ +G R E+ GEVEG E E +E +E+G G EEE +G
Sbjct: 777 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE-----QETKEKGSGREEE-KGVV 830
Query: 845 EEGEGEEEEGEGKGEEEGEE 864
G E KG ++ EE
Sbjct: 831 TNGLDLSPADEKKGGDKSEE 850
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 131 bits (330), Expect = 3e-30
Identities = 133/480 (27%), Positives = 214/480 (44%), Gaps = 62/480 (12%)
Query: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
P T +VE P+ K ++ + VE E KV + E E L+ +T
Sbjct: 53 PITISSKIQKPKVEAPKLK----------VQHKFVEEIIEETKVEDEKSEMEEALTA-IT 101
Query: 632 DKAEVS--EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689
++ VS E K ++ E E+ PE ++E K K +
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAE---------------EEEVAAKKSPVKATAPEVKE 146
Query: 690 GEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
EGEKE EE+ Q+E E+ + ++ + EEGG E+ G E+EEG++EE
Sbjct: 147 EEGEKE------------EEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEE-- 192
Query: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE-KGEEEGDQGEGEEEETEGRGEEK 808
GE + E EGEE E + EK+ E K EE A KEE + + ++ E + E+
Sbjct: 193 ---GETEAEAEGEEAEAKEEKKV-EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 248
Query: 809 EEGGEVEGGEVEE-GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
+ V VEE GK + E +G+ + EE +G+ + EE+ +
Sbjct: 249 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE-KGKSPVSKSPVEEKAKSPVP 307
Query: 868 EEEGEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
+ EE + + E +GE + EEE E E +EE + EE+ + E+++ E +EE
Sbjct: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
Query: 927 EGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG 986
+ ++ + EG+ + E E E+ GEG EEEG +G +G +
Sbjct: 368 AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK------ 421
Query: 987 EGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEER 1046
E GE EG+EE E E + +G G EEE+G V ++ +E++G ++ EE+
Sbjct: 422 --EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD----LSPADEKKGGDKSEEK 475
Score = 127 bits (319), Expect = 6e-29
Identities = 140/441 (31%), Positives = 199/441 (45%), Gaps = 82/441 (18%)
Query: 732 EEEHGEGEEEEGDREEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789
E+E E EE EE + E KE E +E E E E+EE KK + +E
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE 146
Query: 790 EGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE-EEEGE 848
E EGE+EE EG+ EE+EE + + EEG E+E E+ EGE+EEGE E E EGE
Sbjct: 147 E----EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
Query: 849 GEEEEGEGKGEEEGEEGEGEEE---------GEEGEGEGEEEEGEGEGEEEGEGEGEEEE 899
E + E K EE+ EE +EE E+ + + E +G+ EE+
Sbjct: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
Query: 900 G-----EGEGEEEGEGEGEEEEGEGKG---------EEEGEEGEGEGEEEEGEGEGEDGE 945
G + EE+G+ + E KG EE+ + + EE + + E G+
Sbjct: 263 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 322
Query: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE------------ 993
GE +EEE E+E E EE+ E + E+ + E+++ E +EE
Sbjct: 323 GEQKEEE-----EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
Query: 994 ------EGEEEG---EEEGEGEEEGEGEGEEEEEGE-------------VEGEVEGEEGE 1031
E +EEG ++E E E+ G GEG EEEG V GEVEG+
Sbjct: 378 KVHLEKETKEEGKPLQQEKEKEKAG-GEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK--- 433
Query: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKI 1091
E E+E +E+G RE+E N + +E++G G++ E+ K V KI
Sbjct: 434 -EEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG-----GDKSEEKV--VVTKTVEKI 485
Query: 1092 KGSVKYGKHKTYQKKSVTNTQ 1112
G K Y KSVT TQ
Sbjct: 486 TSEGGDGATK-YITKSVTVTQ 505
Score = 107 bits (268), Expect = 5e-23
Identities = 114/376 (30%), Positives = 171/376 (45%), Gaps = 62/376 (16%)
Query: 797 EEEETEGRGEEKEEG-----GEVEGGEVEEGKGEREEEEEEGEGEEEEGEG--------- 842
EE + E E EE E+ EE K EE+EEE E EEEE
Sbjct: 82 EETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATA 141
Query: 843 -EEEEGEGEEEEGEGKGEEEGEEGEG------EEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
E +E EGE+EE EG+ EEE EE EG EE G E EG E+EEGE +EEGE E
Sbjct: 142 PEVKEEEGEKEEEEGQ-EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE---QEEGETEA 197
Query: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGE-------EEGEEGEGEGEEEEGEGEG------- 941
E E E E +EE + E + EE K E E+ E+ + + E +G
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
Query: 942 ---EDGEGEGEEEEGEWEGEEEEGEGEGEEEG---------EGEGEEGEGEGEEEEGEGE 989
E G+ + E +G+ + EE+G E + + + EE + +
Sbjct: 258 PVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSK 317
Query: 990 GEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE-----EGE 1044
E +GE++ EEE E +E + E E++E + + E ++ E +EE E +
Sbjct: 318 AEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSV 377
Query: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE--YKKVSKIKGSVKYGKHKT 1102
+ E E +E + ++E+E+E E G EE G + K+ + G V+ GK +
Sbjct: 378 KVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE-GKEEV 436
Query: 1103 YQKKSVTNTQGNGKEQ 1118
Q+ T +G+G+E+
Sbjct: 437 EQE---TKEKGSGREE 449
Score = 101 bits (251), Expect = 5e-21
Identities = 101/348 (29%), Positives = 153/348 (43%), Gaps = 30/348 (8%)
Query: 819 VEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG 878
VEE E + E+E+ E EE EE +EE + EE+ EE E EEE E +
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE--EVAAKK 134
Query: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938
+ +E EGE EEEEG+ E EEE EG ++ EG E+EG + EGE+EEGE
Sbjct: 135 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194
Query: 939 GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE---------EEEGEGE 989
E E EGE E + E + EE+ E +EE + + + E EE+G+
Sbjct: 195 TEAE-AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSP 253
Query: 990 GEEEEGEEEG---------EEEGEG-------EEEGEGEGEEE--EEGEVEGEVEGEEGE 1031
+ EE+G EE+G+ EE+G+ + EE + E
Sbjct: 254 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 313
Query: 1032 GEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKI 1091
+ + E G+ E +E E++ E + + E++EE+ K ++ E +V I
Sbjct: 314 AKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 373
Query: 1092 KGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKK 1139
SVK K +++ Q KE+ + G GS+K
Sbjct: 374 TKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 421
Score = 85.5 bits (210), Expect = 3e-16
Identities = 109/380 (28%), Positives = 165/380 (43%), Gaps = 61/380 (16%)
Query: 512 EKSLKLSPVQKQKKQ--QTIGELTQDTALTENDD------SDEYEEMSEMKEGKACKQHV 563
E + K SPV+ + + GE ++ E ++ SD+ EE KEG + K+
Sbjct: 129 EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEG 188
Query: 564 SQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKT 623
Q EE E E EG E EE++VE E V K
Sbjct: 189 EQ----------------EEGETEAEAEGEE---AEAKEEKKVEEKSEEVAT------KE 223
Query: 624 EILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEE-GSSGAEHWQDEEREKGE---- 678
E+++D +K E ++ E G EE G S EE+ K
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
Query: 679 --KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ-EMEEGGEEEH 735
++KG+ + + EK A+ K E + + E +G QKE + E++E +EE
Sbjct: 284 PVEEKGKSPVSKSPVEEK--AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK 341
Query: 736 GEGEEEE-GDREEEEEKEGEGKEEGEGE--------EVEGERE-KEEGERKKEERAGKEE 785
E +EE+ D E+++ E KEE E +V E+E KEEG+ ++E+ KE+
Sbjct: 342 VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKE-KEK 400
Query: 786 KGEEEGDQGEGEEEETEG-RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844
G E G + EG ++ +G R E+ GEVEG E E +E +E+G G EEE +G
Sbjct: 401 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE-----QETKEKGSGREEE-KGVV 454
Query: 845 EEGEGEEEEGEGKGEEEGEE 864
G E KG ++ EE
Sbjct: 455 TNGLDLSPADEKKGGDKSEE 474
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 131 bits (330), Expect = 3e-30
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 10/281 (3%)
Query: 50 VTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNV 108
VT N+++++FG N LG G + P ++ L +K+K + G H L+STE G V
Sbjct: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
Query: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168
YA G N QLG G T + + ++ +++ GS+ S AL DG +F WG N+
Sbjct: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 169 EGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
GQ+G + +N P++VT K V I+CG S V +GE+Y +G NG+LGL
Sbjct: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
Query: 226 NQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFET 283
N GN TP V+ + + Q+ CG HT+ LT E +Y +G +GQLG G
Sbjct: 217 NN--GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGN-KNNL 273
Query: 284 SEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
P I +++ + +C HT A T G +Y +G R
Sbjct: 274 LSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
Score = 110 bits (274), Expect = 1e-23
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 13/271 (4%)
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL- 155
+ L T+ V+ G N LG GD + + + KIK LS GS L
Sbjct: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGK-KIKSLSYGSGPHVLLS 90
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELY 212
TEDG ++ WG N Q+G + P QV K V ++CG +HS + DGE++
Sbjct: 91 TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVF 150
Query: 213 VFGEPENGKLGLPNQLLGNHRTPQLVSEIP--EKVIQVACGGEHTVVLTENA-VYTFGLG 269
+G G++G + N TP+ V+ ++V+ +ACG ++ + +N VY +G
Sbjct: 151 AWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
Query: 270 QFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGL 329
GQLGLG + + P + + ++ I CG HT +TD GL+Y +G +G+LG
Sbjct: 209 GNGQLGLGNNGNQLT-PVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
Query: 330 GLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
G +N N P +V++ AC H
Sbjct: 268 GNKN--NLLSPAHIMVEKERVVEIAACHSAH 296
Score = 106 bits (264), Expect = 1e-22
Identities = 69/230 (30%), Positives = 114/230 (49%), Gaps = 8/230 (3%)
Query: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPT--CVKALKPEKVKLAACGRNHTLVST 103
H + T + +Y +G N + QLG G+ + P C L + V++A CG +H++
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVA-CGSHHSMALA 144
Query: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFM 163
G V+A G NN GQ+G G T + T ++ ++ ++ G +S A+ ++G ++
Sbjct: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
Query: 164 WGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGK 221
WG N GQ+GL N N P +V V+ I CGY H+ +T +G LY +G G+
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264
Query: 222 LGLPNQLLGNHRTPQLVSEIPEKVIQV-ACGGEHTVVLTENAVYTFGLGQ 270
LG N+ N +P + E+V+++ AC HT + + GQ
Sbjct: 265 LGTGNK--NNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
Score = 95.9 bits (237), Expect = 2e-19
Identities = 61/193 (31%), Positives = 100/193 (51%), Gaps = 5/193 (2%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV-KALKPEKVKLAACGR 96
V ++CG HS + + +++ +G NN GQ+G GS + P V L ++V ACG+
Sbjct: 131 VEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ 190
Query: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
++ + G VY G N GQLGLG+ + T ++ S + Q+ G + ALT
Sbjct: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALT 249
Query: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYV 213
++G L+ WG N+ GQ+G N +N+ P + + K V +C H SA T G +Y+
Sbjct: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYM 309
Query: 214 FGEPENGKLGLPN 226
+G+ + LP+
Sbjct: 310 WGQCRGQSVILPH 322
Score = 85.1 bits (209), Expect = 3e-16
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 8/191 (4%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
V ++CG S V N ++Y +G N GQLGLG+ P V AL V CG
Sbjct: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA 243
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSA--GSNTSAAL 155
HTL T+ G +YA G N GQLG G+ + N + ++ +++A ++TSAA
Sbjct: 244 HTLALTDEGLLYAWGANTYGQLGTGN--KNNLLSPAHIMVEKERVVEIAACHSAHTSAAK 301
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKP-VSWISCGYYHSAFVTTDGEL- 211
T+ G ++MWG + L ++++ V P VSW H F+T L
Sbjct: 302 TQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLK 361
Query: 212 YVFGEPENGKL 222
F PE L
Sbjct: 362 KEFDSPETADL 372
Score = 79.0 bits (193), Expect = 2e-14
Identities = 58/219 (26%), Positives = 104/219 (47%), Gaps = 8/219 (3%)
Query: 148 GSNTSAAL--TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYY-HS 202
G++ S AL T++ +F++G N +G + + VP+++ GK + +S G H
Sbjct: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
Query: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-EN 261
T DG +Y +G +LG G + + ++V++VACG H++ L +
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
Query: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321
V+ +G GQ+G G+ + + KV + + + I+CG+ + + D G +Y +G
Sbjct: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
Query: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
+G+LGLG N N P + V + CG H
Sbjct: 208 NGNGQLGLG--NNGNQLTPVRVAALHSVCVNQIVCGYAH 244
Score = 51.6 bits (122), Expect = 4e-06
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 234 TPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
+PQ ++ I + + E V + V+ FGL LG G T PK +E +
Sbjct: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ-STLVPKKLEGLC 72
Query: 294 DQTISYISCGEN-HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPT-LCSNFLRFIV 351
+ I +S G H L T+ G++Y +G + +LG G N P +C+N L V
Sbjct: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN--QGIAPVQVCTNLLIKQV 130
Query: 352 KLVACGGCHMVVFAA 366
VACG H + AA
Sbjct: 131 VEVACGSHHSMALAA 145
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 129 bits (324), Expect = 2e-29
Identities = 98/336 (29%), Positives = 165/336 (49%), Gaps = 15/336 (4%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLG-SKSAISKPTCVKALKPEKVKLAAC-- 94
V ++ G + VT K+Y G G+LGLG S + P + AL VK A
Sbjct: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
Query: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
G H T G V++ G ++G+LG + +I ++ +I+ ++ GS+ SAA
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAA 3113
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYY--HSAFVTTDGE 210
LT G L+ WG G++G + + P+ V + G V ++CG + +T +G
Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
Query: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAV-YTFGL 268
++ +G+ + GKLG N PQ + + + V Q+ CG + ++ LT++ V +T+G
Sbjct: 3174 VFSWGDGDFGKLGRGGSEGCN--IPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Query: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
G + +LG G+ + +P+V+E +R + I +++ G H +TD G +Y +GD HG+ G
Sbjct: 3232 GDYFRLGHGSDV-HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQG 3290
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVF 364
G PTL + VACG H V +
Sbjct: 3291 NGTTTVNRK--PTLVQGLEGQKITRVACGSSHSVAW 3324
Score = 129 bits (324), Expect = 2e-29
Identities = 80/282 (28%), Positives = 147/282 (52%), Gaps = 10/282 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
V + G H+ +T + K++ +G + G+LG S+ KP ++ALK ++++ ACG +
Sbjct: 3050 VAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSN--TSAAL 155
H+ T G +Y G G+LG GD + ++ H++ Q++ GS + AL
Sbjct: 3110 HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLAL 3168
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKPVSWISCGYYHSAFVTTDGELYV 213
T++G +F WGD G++G +PQ + G+ V I CG S +T G ++
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEI-PEKVIQVACGGEHTVVLTENA-VYTFGLGQF 271
+G+ + +LG + + + R PQ+V + +K++ VA G H + +T++ VY +G
Sbjct: 3229 WGKGDYFRLGHGSDV--HVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
Query: 272 GQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDI 313
GQ G GT +P +++ + Q I+ ++CG +H+ T +
Sbjct: 3287 GQQGNGTTTV-NRKPTLVQGLEGQKITRVACGSSHSVAWTTV 3327
Score = 129 bits (323), Expect = 2e-29
Identities = 97/337 (28%), Positives = 164/337 (48%), Gaps = 14/337 (4%)
Query: 37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAA--C 94
PV L G++ VT + KLY G G+LG+G ++S PT +++++ +K A
Sbjct: 3987 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS 4046
Query: 95 GRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAA 154
G H L + G VY+ G +G+LG G+ + VI ++ ++AG SA
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRG-IEVVDVAAGGAHSAC 4105
Query: 155 LTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGY--YHSAFVTTDGE 210
+T G L+ WG G++G + + P+ V G V I+CG + +T D
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 211 LYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVLTEN-AVYTFGL 268
++ +G+ + GKLG + P + + V++V CG + +V LT++ AVYT+G
Sbjct: 4166 VWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGK 4223
Query: 269 GQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
G + +LG G+ P+ ++ ++ + + I+ G H T+ G +YT+GD G+LG
Sbjct: 4224 GDYHRLGHGSD-DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
Query: 329 LGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
G N P L + V VACG H + ++
Sbjct: 4283 DGTTNAIQR--PRLVAALQGKKVNRVACGSAHTLAWS 4317
Score = 125 bits (313), Expect = 3e-28
Identities = 93/291 (31%), Positives = 147/291 (50%), Gaps = 11/291 (3%)
Query: 48 AVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGN 107
+ T K++++G N+ QLG S I P+ + L V A G T G
Sbjct: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
Query: 108 VYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS--AGSNTSAALTEDGRLFMWG 165
VYA G G+LGLG + S + +K+++ +G + ALT DG++F WG
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
Query: 166 DNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLG 223
+ +G++G + N P+ + K + I+CG HSA +T+ GELY +G E G+LG
Sbjct: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
Query: 224 LPNQLLGNHRTPQLVSE-IPEKVIQVACGGE--HTVVLT-ENAVYTFGLGQFGQLGLGTF 279
+ P++V + +VIQVACG T+ LT E V+++G G FG+LG G
Sbjct: 3133 HGDNT--TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGG- 3189
Query: 280 LFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
+ P+ IE + Q + I CG + +T G+++T+G G + +LG G
Sbjct: 3190 SEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG 3240
Score = 111 bits (277), Expect = 5e-24
Identities = 75/231 (32%), Positives = 118/231 (51%), Gaps = 8/231 (3%)
Query: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-- 97
++CG HSA +T + +LY +G +G+LG G + KP VK L +V ACG
Sbjct: 3104 IACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDA 3163
Query: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTE 157
TL T+ G V++ G + G+LG G +E N I + + Q+ G+ S ALT+
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-VCQIECGAQFSLALTK 3222
Query: 158 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYYHSAFVTTDGELYVFG 215
G ++ WG ++G + +V PQ V GK + ++ G H VT G++Y +G
Sbjct: 3223 SGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWG 3282
Query: 216 EPENGKLGLPNQLLGNHRTPQLVSEIP-EKVIQVACGGEHTVVLTENAVYT 265
+ ++G+ G N +R P LV + +K+ +VACG H+V T V T
Sbjct: 3283 DNDHGQQG--NGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVAT 3331
Score = 102 bits (253), Expect = 3e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 30/310 (9%)
Query: 64 WGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG---QLG 120
WG +G + + P + L V AC L+ + G VY N++ QL
Sbjct: 428 WGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLV 487
Query: 121 LGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNV 180
G RN + + H + AL G ++ WG G++G + +
Sbjct: 488 QG-LASRNIVKIAAHSDGHHYL-----------ALAATGEVYSWGCGDGGRLGHGDTVPL 535
Query: 181 CVPQQVTI------GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT 234
P+ ++ GK V I+CG +SA +T +GELY +G G+LG + +
Sbjct: 536 EEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS--EDEAI 593
Query: 235 PQLVSEIPE-KVIQVACGG--EHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIE 290
P LV+ + KVI VACG T+ +TEN V+++G G +G+LG G PK+IE
Sbjct: 594 PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLIE 652
Query: 291 NIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
++D + + CG + +T G +Y++G G + +LG G E + P L
Sbjct: 653 KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRY--PKLLEGLQGKK 710
Query: 351 VKLVACGGCH 360
V VA G H
Sbjct: 711 VIDVAAGSTH 720
Score = 98.6 bits (244), Expect = 3e-20
Identities = 70/236 (29%), Positives = 115/236 (48%), Gaps = 8/236 (3%)
Query: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
VH++CG +SA +T +LY +G N+G+LG GS + P V LK KV ACG
Sbjct: 554 VHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 98 --HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
TL TE G V++ G + G+LG G ++ T +I +K + GS S AL
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVK-VRCGSQFSIAL 672
Query: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYV 213
T+DG+++ WG ++G +V P+ + GK V ++ G H +T D E++
Sbjct: 673 TKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHS 732
Query: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEK-VIQVACGGEHTVVLTENAVYTFGL 268
+G N + + L P + + K ++ +ACG + + + ++ GL
Sbjct: 733 WG--SNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGL 786
Score = 92.8 bits (229), Expect = 2e-18
Identities = 70/236 (29%), Positives = 119/236 (50%), Gaps = 12/236 (5%)
Query: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGY 199
I++ +AG ++A + ++F+WG N + Q+G S + VP + V ++ G
Sbjct: 2944 IRKKAAGLESAATIRT--KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS 3001
Query: 200 YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTV 256
VT +G++Y GE NG+LGL G P+ ++ + V++ V GG H
Sbjct: 3002 KSLFAVTVEGKVYACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
Query: 257 VLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGL 315
LT + V+++G G G+LG + + +P++IE ++ + I I+CG +H+A +T G
Sbjct: 3061 ALTVDGKVFSWGEGDDGKLGHFSRM-NCDKPRLIEALKTKRIRDIACGSSHSAALTSSGE 3119
Query: 316 MYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFAAPHRGV 371
+YT+G G +G+LG G + T P + L V VACG A G+
Sbjct: 3120 LYTWGLGEYGRLGHG--DNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGL 3173
Score = 70.9 bits (172), Expect = 7e-12
Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Query: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
+ V GD + VT N +++ +G ++G+LG G P ++ L+ V CG
Sbjct: 606 IDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCG 665
Query: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL 155
++ T+ G VY+ G + +LG G TEE + + K+ ++AGS AL
Sbjct: 666 SQFSIALTKDGQVYSWGKGDNQRLGHG-TEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724
Query: 156 TEDGRLFMWGDNSEGQ 171
TED + WG N + Q
Sbjct: 725 TEDSEVHSWGSNDQCQ 740
Score = 67.0 bits (162), Expect = 1e-10
Identities = 47/159 (29%), Positives = 75/159 (47%), Gaps = 11/159 (6%)
Query: 8 MPDSGAVFTFGKSKFAE---------NNPGKFWFKNDVPV-HLSCGDEHSAVVTGNNKLY 57
+ D G VF++G F + N P N V + CG + S +T + ++
Sbjct: 3168 LTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVW 3227
Query: 58 MFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEG 117
+G ++ +LG GS + KP V+ L+ +K+ A G H L T+ G VYA G N+ G
Sbjct: 3228 TWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHG 3287
Query: 118 QLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Q G G T ++ + KI +++ GS+ S A T
Sbjct: 3288 QQGNGTTTVNRKPTLVQGLEGQ-KITRVACGSSHSVAWT 3325
Score = 55.8 bits (133), Expect = 2e-07
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 11 SGAVFTFGKSKFAENNPGKF----------WFKNDVPVHLSCGDEHSAVVTGNNKLYMFG 60
SGAV+T+GK + G + + ++ G H T + ++Y +G
Sbjct: 4215 SGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
Query: 61 SNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTL 100
N+ GQLG G+ +AI +P V AL+ +KV ACG HTL
Sbjct: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL 4314
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 126 bits (317), Expect = 1e-28
Identities = 88/214 (41%), Positives = 115/214 (53%), Gaps = 24/214 (11%)
Query: 806 EEKEEGGEVEGGEVE-EGKGEREEEEEEGE---------GEEEEGEGEEEEGEGEEE--- 852
+EKEE +G + + K E + EEEE + +G+++E G +E
Sbjct: 689 KEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVA 748
Query: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE----EEGEGEGEEEG 908
E E GE GEEGE EGE E G E + EGEGE E +G+GEE E EG+G+ EG
Sbjct: 749 EAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEG 808
Query: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
E EGE + GE +G EGE E +E E GE +E+G +G +G G+ EE
Sbjct: 809 EDEGEIHAED--GEMKGNEGETESQELSAENHGE----AKNDEKGVEDGGGSDG-GDSEE 861
Query: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002
E E E E+ E E EEE+ E E EEEE EE+G EE
Sbjct: 862 EEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 119 bits (299), Expect = 1e-26
Identities = 88/225 (39%), Positives = 115/225 (51%), Gaps = 17/225 (7%)
Query: 843 EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 902
EE +G + + K E + EE E + + +G+ +E G+ + E E
Sbjct: 693 EESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAES 752
Query: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE-DGEGEGEEEEGEWEGEEEE 961
GE GE EGE GE E EE G + EGEGE E G+GE E+E E EG+
Sbjct: 753 TGEMPGE------EGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGK--- 803
Query: 962 GEGEGEEEGEGEGEEGEGEGEEEEGEGE--GEEEEGE----EEGEEEGEGEEEGEGEGEE 1015
G+ EGE+EGE E+GE +G E E E + E GE E+G E+G G + G+ E EE
Sbjct: 804 GDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEE 863
Query: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEEE-GEEREKEGEGEENRRNR 1059
EEE E E E E EE E E EEEE EEE G E + E R+ +
Sbjct: 864 EEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQ 908
Score = 116 bits (290), Expect = 1e-25
Identities = 80/210 (38%), Positives = 110/210 (52%), Gaps = 30/210 (14%)
Query: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEG----------------EGEEEEGEGEGEDGEG 946
E EEE +G + + K E + EE E +G+++E G G++
Sbjct: 690 EKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPG-GQEDVA 748
Query: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGE-EGEGEGEEEEGEGEGEEEEGEEEGEEEGEG 1005
E E GE GEE E GEGE E + GE + EGEGE E +G+ EE E+E E EG+G
Sbjct: 749 EAEST-GEMPGEEGETAGEGETEEKSGGETQPEGEGETET---QGKGEECEDENEAEGKG 804
Query: 1006 EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE-----GEGEENRRNRE 1060
+ EGE EGE E +GE++G EGE E +E E GE + E G G + + E
Sbjct: 805 DNEGEDEGEIHAE---DGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEE 861
Query: 1061 EEEEEEGKYQETGEEENERQDGEEYKKVSK 1090
EEEEEE + +E EEE E ++ EE ++ K
Sbjct: 862 EEEEEEEQEEEEEEEEQEEEEEEEEEEEEK 891
Score = 115 bits (288), Expect = 2e-25
Identities = 89/224 (39%), Positives = 114/224 (50%), Gaps = 27/224 (12%)
Query: 777 KEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE--------VEGGEVEEGKGEREE 828
+E R KE+ EE +G + + + E K E E V V + KG+
Sbjct: 683 REVRLAKEK---EEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGD--- 736
Query: 829 EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE----GEEEEGE 884
++E G +E+ E GE EEGE GE E EE G E EGEGE G+ EE E
Sbjct: 737 -QKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECE 795
Query: 885 GEGEEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGKGEEEGEEGEGEGEEEE---GEGE 940
E E EG+G + EGE EGE E GE + EGE + +E E GE + +E +G
Sbjct: 796 DENEAEGKG---DNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGG 852
Query: 941 GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984
G DG G+ EEEE E E +EEE E E +EE E E EE E +G EE
Sbjct: 853 GSDG-GDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 105 bits (262), Expect = 2e-22
Identities = 84/223 (37%), Positives = 109/223 (48%), Gaps = 13/223 (5%)
Query: 715 REQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK-EGEGKEEGEGEEVEGEREKEEG 773
RE KE+ +E G + + E EEE K +++G++++ G
Sbjct: 683 REVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPG 742
Query: 774 --ERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831
E E + E GEE GEGE EE G GE + EG EG +GKGE E+E
Sbjct: 743 GQEDVAEAESTGEMPGEEGETAGEGETEEKSG-GETQPEG---EGETETQGKGEECEDEN 798
Query: 832 EGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEG 891
E EG+ + EGE+E GE E+GE KG EGE E + E GE + E E+ G
Sbjct: 799 EAEGKGDN-EGEDE-GEIHAEDGEMKGN----EGETESQELSAENHGEAKNDEKGVEDGG 852
Query: 892 EGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE 934
+G + E E E EEE E E EEEE E + EEE EE E EE
Sbjct: 853 GSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 105 bits (262), Expect = 2e-22
Identities = 82/210 (39%), Positives = 104/210 (49%), Gaps = 25/210 (11%)
Query: 674 REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGE----------EQEQKEREQGHQK-- 721
+EK E+ +G +P + E+EE K + +QKE G +
Sbjct: 689 KEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVA 748
Query: 722 --ERNQEMEEGGEEEHGEGE-EEEGDREEEEEKEGEGKEEGEGEEVEGEREKE-----EG 773
E EM E GEGE EE+ E + E EGE + +G+GEE E E E E EG
Sbjct: 749 EAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEG 808
Query: 774 ERKKEERAGKEEKGEEEGDQGEGEEEE--TEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831
E + E A E GE +G++GE E +E E GE K + VE G +G EEEEE
Sbjct: 809 EDEGEIHA---EDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEE 865
Query: 832 EGEGEEEEGEGEEEEGEGEEEEGEGKGEEE 861
E E EEEE E E+EE E EEEE E KG EE
Sbjct: 866 EEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 103 bits (257), Expect = 9e-22
Identities = 79/224 (35%), Positives = 105/224 (46%), Gaps = 44/224 (19%)
Query: 705 RDGEEQEQKEREQGHQKERNQEMEEGGEEEH------------------GEGEEEEGDRE 746
R +E+E++ QG + + + E EEE G+ +E G +E
Sbjct: 686 RLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQE 745
Query: 747 EEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGE 806
+ E E G+ GE E GE E EE + G E +GEGE E T+G+GE
Sbjct: 746 DVAEAESTGEMPGEEGETAGEGETEE------------KSGGETQPEGEGETE-TQGKGE 792
Query: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG---- 862
E E+ E EG EG+ E E E+GE + EGE E +E E GE K +E+G
Sbjct: 793 ECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENH-GEAKNDEKGVEDG 851
Query: 863 --------EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
EE E EEE +E E E EE+E E E EEE E +G EE
Sbjct: 852 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 81.3 bits (199), Expect = 5e-15
Identities = 71/224 (31%), Positives = 106/224 (47%), Gaps = 21/224 (9%)
Query: 583 EVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD----DLTDKAEVSE 638
EV + +EKE E+S G Q E + K ++ D+ + +
Sbjct: 684 EVRLAKEKE--EESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENP 741
Query: 639 GKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGE-KDKGRGEMERPGEGEKELA 697
G + V EAE E G EEG + E + EE+ GE + +G GE E G+GE+
Sbjct: 742 GGQEDVAEAESTGEMPG----EEGETAGEG-ETEEKSGGETQPEGEGETETQGKGEECED 796
Query: 698 EKEEWKKRD--GEEQEQKEREQGHQK--ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEG 753
E E K D GE++ + E G K E E +E E HGE + +E E +G
Sbjct: 797 ENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVE-----DG 851
Query: 754 EGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGE 797
G + G+ EE E E E++E E ++EE+ +EE+ EEE ++G E
Sbjct: 852 GGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEE 895
Score = 70.1 bits (170), Expect = 1e-11
Identities = 78/322 (24%), Positives = 143/322 (44%), Gaps = 44/322 (13%)
Query: 459 VLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMT-----HIMSLNSNEK 513
V++ +DL +P + +DE+ ++ S + +T + N T + + L+S +
Sbjct: 622 VMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDP 681
Query: 514 SLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPA 573
L+ + K+K+++++ + + + + E EE +++ PA
Sbjct: 682 -LREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKL------------------PA 722
Query: 574 TTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDK 633
T+ +P+ K +++ G +++V E ++ G E+ E + T+
Sbjct: 723 VTVTP-----APVPDIKGDQKENPGG---QEDVAEAESTGEMPG---EEGETAGEGETE- 770
Query: 634 AEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGE 693
E S G+ + GE E +G+G+ CE+ + +E ++GE GEM + EGE
Sbjct: 771 -EKSGGETQPEGEGETETQGKGE-ECEDENEAEGKGDNEGEDEGEIHAEDGEM-KGNEGE 827
Query: 694 KEL----AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
E AE K D + E G E +E EE EEE E E+EE + EEEE
Sbjct: 828 TESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEE-EEEEEE 886
Query: 750 EKEGEGKEEGEGEEVEGEREKE 771
E+E +G EE + R+K+
Sbjct: 887 EEEEKGNEEPLSLDWPETRQKQ 908
Score = 53.5 bits (127), Expect = 1e-06
Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 27/146 (18%)
Query: 965 EGEEEGEGEGEEGEGEGEEEEGEGEGE---------------EEEGEEEGEEEGEGE-EE 1008
E EEE +G + + + E E E + +G+++ G+ + E
Sbjct: 690 EKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAE 749
Query: 1009 GEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068
E GE+ GEEGE GE E E+ G E + EGEGE + + EE E+E +
Sbjct: 750 AES----------TGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENE 799
Query: 1069 YQETGEEENERQDGEEYKKVSKIKGS 1094
+ G+ E E +GE + + ++KG+
Sbjct: 800 AEGKGDNEGE-DEGEIHAEDGEMKGN 824
Score = 35.4 bits (80), Expect = 0.31
Identities = 38/154 (24%), Positives = 58/154 (37%), Gaps = 58/154 (37%)
Query: 993 EEGEEEGEEEG---EGEEEGEGEGEEEEEGEVEG---------EVEGEEGEGEGEEEE-- 1038
+E EEE +G + + + E + EEEE ++ +++G++ E G +E+
Sbjct: 689 KEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVA 748
Query: 1039 -----GEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKG 1093
GE GEE E GEGE EE+ G+ Q GE E E
Sbjct: 749 EAESTGEMPGEEGETAGEGET-------EEKSGGETQPEGEGETE--------------- 786
Query: 1094 SVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSK 1127
TQG G+E + + K
Sbjct: 787 -----------------TQGKGEECEDENEAEGK 803
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 122 bits (306), Expect = 2e-27
Identities = 120/439 (27%), Positives = 170/439 (38%), Gaps = 26/439 (5%)
Query: 650 GPEGRGDGTCE--EGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDG 707
G G G E EGS GAE E +G ++ G G + + E + G
Sbjct: 29 GEPGAAGGEAEGPEGSEGAE----------EAPRGAAAVKEAGGGGPDRGPEAEARGTRG 78
Query: 708 EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGE 767
E E E+G + E+ +GGEE G + E + E G+ + E E+
Sbjct: 79 AHGET-EAEEGAPE--GAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAP 135
Query: 768 REKEEGERKKE--ERAGKEEKGEEEGDQGE-GEEEETEG-RGEEKEEGGEVEGGEVEEGK 823
+EE E++ E E + E G+ +G G+ E EG G+ E G V EG
Sbjct: 136 ERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGP 195
Query: 824 GEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEG 883
+ E G+ + EG G+ + EG + E G+ EG E G
Sbjct: 196 AGDSVDAEGPLGDNIQAEGPA--GDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAG 253
Query: 884 E--GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
+ G+G E G G+ E EG + + EG E + G+G + E
Sbjct: 254 DPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEV 313
Query: 942 EDGEGEGEEE-EGEWEGEEE-EGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE-EGEEE 998
GE G E W+ EE E G E G+ GE+ G+G +E E EE
Sbjct: 314 AAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEER 373
Query: 999 GEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRN 1058
E EG E E G EEE + E G E E + EE EG GE R N
Sbjct: 374 RERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVN 433
Query: 1059 REEEEEEEGKYQETGEEEN 1077
E+ E + + G+E +
Sbjct: 434 GRREDGEASEPRALGQEHD 452
Score = 113 bits (283), Expect = 9e-25
Identities = 121/432 (28%), Positives = 166/432 (38%), Gaps = 52/432 (12%)
Query: 687 ERPGEGEKELAEKEEWKKRDGEEQEQK-----EREQGHQKERNQEMEEGGEE-EHGEGEE 740
ERPGE E E + +G E+ + + G +R E E G HGE E
Sbjct: 26 ERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEA 85
Query: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD-QGEGEEE 799
EEG E E +G G+E ++VEG G+ +GE G+ Q E E+
Sbjct: 86 EEGAPEGAEVPQG-GEETSGAQQVEGASP------------GRGAQGEPRGEAQREPEDS 132
Query: 800 ETEGRGEEKEEGGEVEGGEVEEGKGEREEEE----EEGEGEEEEGEGEEEEGE-GEEEEG 854
R EE E+ EV G G+ + E + E E G+ E EG G+ +
Sbjct: 133 AAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDA 192
Query: 855 EGKG----EEEGEEGEG-EEEGEEGEGE------GEEEEGEGEGEEEGEGEG------EE 897
EG + EG G+ + EG G+ G+ + EG + + EG E
Sbjct: 193 EGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEA 252
Query: 898 EEGEGEGEEEGEGEGEEEEGEGKG----EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEG 953
+ G+G E G G+ E EG + EG G E + G DG + E
Sbjct: 253 GDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSG-DGSLSPQAEAI 311
Query: 954 EWEGEEEEGEGEGEEEGEG--EGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG 1011
E E G GE + E E +G EE G+ + GE+ G+G ++ G
Sbjct: 312 EVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDR---VGDGPQQEPG 368
Query: 1012 EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
E EE E EG E E GE E + GE E E N EE E
Sbjct: 369 EDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGE 428
Query: 1072 TGEEENERQDGE 1083
R+DGE
Sbjct: 429 AARVNGRREDGE 440
Score = 108 bits (270), Expect = 3e-23
Identities = 106/382 (27%), Positives = 145/382 (37%), Gaps = 24/382 (6%)
Query: 730 GGEEEHGEGEE--EEGDREEEEEKEGEGKEEGEGEEVE--------GEREKEEGERKKEE 779
GGE E EG E EE R KE G G E E GE E EEG + E
Sbjct: 35 GGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAE 94
Query: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEE 839
+G EE + E + GRG + E GE + + ER+EE E+ E E
Sbjct: 95 ----VPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQ-RPEVPE 149
Query: 840 GEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGE-GEGEEEEGEGEGEEEGEGE-GEE 897
G E G+ + EG E E G+ EG G+ + EG + EG G+
Sbjct: 150 GSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDN 209
Query: 898 EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG 957
+ EG + + EG + G+ + EG + G D G+G E G G
Sbjct: 210 IQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAG-DPAGDGVEA-GVPAG 267
Query: 958 EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE-EGEEEGEEEGEGEEEGEGEGEEE 1016
+ E EG + + EG G E + G+ + E E GE G GE
Sbjct: 268 DSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELA 327
Query: 1017 EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEE 1076
+ E EV G +G E + + E ++ G+G + +EE E G E
Sbjct: 328 WDAAEEAEVPGVKGSEEAAPGDARADAGE-DRVGDGPQQEPGEDEERRERSP---EGPRE 383
Query: 1077 NERQDGEEYKKVSKIKGSVKYG 1098
E GEE S G G
Sbjct: 384 EEAAGGEEESPDSSPHGEASRG 405
Score = 100 bits (249), Expect = 8e-21
Identities = 112/416 (26%), Positives = 158/416 (37%), Gaps = 53/416 (12%)
Query: 589 EKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGK-AKSVGEA 647
E EG E S+G +E VK GG D +AE + A EA
Sbjct: 37 EAEGPEGSEG----AEEAPRGAAAVKEAGGG-------GPDRGPEAEARGTRGAHGETEA 85
Query: 648 EDG-PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRD 706
E+G PEG E +SGA+ + +G + + RGE +R E +EE ++R
Sbjct: 86 EEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRP 145
Query: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEH--GEGEEEEGDREEEEEKEGEGKEEGEGEEV 764
+ E G + + + E E G+ E EG + + EG + + E
Sbjct: 146 EVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGP 205
Query: 765 EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG 824
G+ + EG A + + G+ + EGR + E G+ G VE G
Sbjct: 206 LGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVP 265
Query: 825 EREEEEEEGE-GEEEEGEGE-----------EEEGEG---------EEEEGEGKGEEEGE 863
+ E EG G+ + EG ++ G+G E GE G GE
Sbjct: 266 AGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGE 325
Query: 864 -------EGE-----GEEEGEEGEGE---GEEEEGEGEGEEEGEGEGEEEEG-EGEGEEE 907
E E G EE G+ GE+ G+G +E GE E E EG EEE
Sbjct: 326 LAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEE 385
Query: 908 GEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE 963
G GEEE + E G E E + E+G EG E G E+GE
Sbjct: 386 AAG-GEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGE 440
Score = 93.6 bits (231), Expect = 1e-18
Identities = 92/316 (29%), Positives = 120/316 (37%), Gaps = 36/316 (11%)
Query: 784 EEKGEEEGDQGEGEEEE--TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841
E +G G QG E E GE GGE EG E EG EE +E G
Sbjct: 6 EPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGA---EEAPRGAAAVKEAGG 62
Query: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 901
G + G E G E E EG EG E GEE G + E G G + E
Sbjct: 63 GGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPR 122
Query: 902 GEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE 961
GE + E E + E EE E E EG GE G+ + EG G+ E
Sbjct: 123 GEAQREPE--------DSAAPERQEEAEQRPEVPEGSASGE--AGDSVDAEGPL-GDNIE 171
Query: 962 GEGEGEEEGEGEGEEGE--------GEGEEEEGE-GEGEEEEGEEEGEEEGEG------E 1006
EG + E EG G+ G+ + EG G+ + EG + EG +
Sbjct: 172 AEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVD 231
Query: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
EG + EG V VE + G+G E G G+ E EG ++ + E
Sbjct: 232 AEGPAGDSVDAEGRVGDSVEAGDPAGDG-VEAGVPAGDSVEAEGPAGDSM----DAEGPA 286
Query: 1067 GKYQETGEEENERQDG 1082
G+ + E + DG
Sbjct: 287 GRARRVSGEPQQSGDG 302
Score = 85.1 bits (209), Expect = 3e-16
Identities = 87/285 (30%), Positives = 109/285 (38%), Gaps = 39/285 (13%)
Query: 827 EEEEEEGEGEEEEGEGEEEEGEGEE--EEGEGKGEEEGEEG-EGEEEGEEGE-------- 875
E E EG +G E E E G GE EG EG EG EE G
Sbjct: 3 EAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGG 62
Query: 876 -GEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG----EGKGEEEGEEGEG 930
G E E G GE E EEG EG E +G GEE G EG G +GE
Sbjct: 63 GGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQG-GEETSGAQQVEGASPGRGAQGEP 121
Query: 931 EGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE----EGEG------EGEEGEGE 980
GE + E ED +EE E E EG GE + EG E E G+
Sbjct: 122 RGEAQR---EPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGD 178
Query: 981 GEEEEGE-GEGEEEEGEEEGEEEGEG------EEEGEGEGEEEEEGEVEGEVEGEEGEGE 1033
E EG G+ + EG + EG + EG + EG V V+ E G+
Sbjct: 179 SVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGD 238
Query: 1034 GEEEEGE--EEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEE 1076
+ EG + E + G+G E + E EG ++ + E
Sbjct: 239 SVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAE 283
Score = 60.8 bits (146), Expect = 7e-09
Identities = 60/187 (32%), Positives = 76/187 (40%), Gaps = 16/187 (8%)
Query: 906 EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG-EGEEEEGEWEGEEEEGEG 964
E E EG +G E E GE GE E EG EG EE +E G
Sbjct: 3 EAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGG 62
Query: 965 EGEEEG---EGEGEEG-EGEGEEEEGEGEGEE--EEGEE-EGEEEGEGEEEGEGEGEEEE 1017
G + G E G G GE E EEG EG E + GEE G ++ EG G G
Sbjct: 63 GGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRG-----A 117
Query: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEEN 1077
+GE GE + E + E +EE E+R + EG + + + EG + E E
Sbjct: 118 QGEPRGEAQREPEDSAAPER--QEEAEQRPEVPEGSAS-GEAGDSVDAEGPLGDNIEAEG 174
Query: 1078 ERQDGEE 1084
D E
Sbjct: 175 PAGDSVE 181
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 122 bits (305), Expect = 3e-27
Identities = 106/361 (29%), Positives = 158/361 (43%), Gaps = 26/361 (7%)
Query: 741 EEGDREEEEEKEG-----EGKEEGEG-----EEVEGEREKEEGERKKEERAGKEEKGEEE 790
EE RE EE G E G ER R E + +E
Sbjct: 356 EETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQE 415
Query: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE 850
G EE + + EK E +GGE EEG E +E E E EEG E+E EG
Sbjct: 416 TATGMAFEEPIDEKKFEKTE----DGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGC 471
Query: 851 EEEG-EGK-GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG 908
+ G EG ++E EEG EE + E ++ + + E G +E E ++
Sbjct: 472 PKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESE------DDL 525
Query: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
E EEE G K EE ++ E E +E+ E + EDG EE G + +EEG +
Sbjct: 526 NKESEEEVGPTKESEE-DDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELH 584
Query: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
E + E E + E E E +G E+ +EEG E E+ E E EE+ +V + E
Sbjct: 585 ENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDE 644
Query: 1029 EGEGEGEEEEGEEEGEEREKEGEGEE---NRRNREEEEEEEGKYQETGEEENERQDGEEY 1085
+ + E +E+G E +++ +EG+ +E + +E+E+ +GK E +E+ D
Sbjct: 645 KEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNE 704
Query: 1086 K 1086
K
Sbjct: 705 K 705
Score = 114 bits (285), Expect = 5e-25
Identities = 111/417 (26%), Positives = 184/417 (44%), Gaps = 43/417 (10%)
Query: 665 GAEHWQDEE--REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKE 722
G +Q EE RE+ E+ +G E + L + E+ R + +
Sbjct: 349 GTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVS---ASERAGPSRARHFSEH 405
Query: 723 RNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG 782
+ E G EE D ++ E+ E + GE EE E +E +KE G
Sbjct: 406 PSTSKMNAQETATGMAFEEPIDEKKFEKTE----DGGEFEEGASENNAKESSPEKEAEEG 461
Query: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
EK EEG G E + E EEG V G E + K E +++ + + EE
Sbjct: 462 CPEKESEEGCPKRGFEGSCSQK--ESEEGNPVRGSEEDSPKKESKKKTLKNDCEEN---- 515
Query: 843 EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 902
G +E E +E EE G + E EE++ E E +E+ + E+ E
Sbjct: 516 ------GLAKESEDDLNKESEEEVGPTK------ESEEDDSEKESDEDCSEKQSEDGSER 563
Query: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962
E EE G + +EEG E+E E + E EE + E + E +G E+ + EG E E
Sbjct: 564 EFEENGLEKDLDEEG---SEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREF 620
Query: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022
+ + +E +E E + E+ + E +E+E EE +E+G E ++ EEG+ +
Sbjct: 621 DEDSDE------KEEEEDTYEKVFDDESDEKEDEEYADEKGL-----EAADKKAEEGDAD 669
Query: 1023 GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079
++ E + E E+ +G+E + EK E +++ N + +EEE ++ ++ +ER
Sbjct: 670 EKLFEESDDKEDEDADGKEVEDADEKLFEDDDS--NEKLFDEEEDSSEKLFDDSDER 724
Score = 111 bits (278), Expect = 3e-24
Identities = 95/330 (28%), Positives = 162/330 (49%), Gaps = 19/330 (5%)
Query: 660 EEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ-EQKEREQG 718
+E ++G + + +K EK + GE E EG E KE +++ EE +KE E+G
Sbjct: 414 QETATGMAFEEPIDEKKFEKTEDGGEFE---EGASENNAKESSPEKEAEEGCPEKESEEG 470
Query: 719 HQK---ERNQEMEEGGEEEHGEGEEEEGDREEEEEK--EGEGKEEGEGEEVEGEREKEEG 773
K E + +E E G EE+ ++E ++K + + +E G +E E + KE
Sbjct: 471 CPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESE 530
Query: 774 ERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG 833
E + +E+ E+E D+ E++ +G E EE G +E EEG E+E E
Sbjct: 531 EEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENG-LEKDLDEEGS---EKELHEN 586
Query: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE--EEEGEGEGEEEG 891
++E E + E E E++ E +EEG E E +E+ +E E E + E+ + E +E+
Sbjct: 587 VLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKE 646
Query: 892 EGEGEEEEG-EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEG-- 948
+ E +E+G E ++ EG+ +E+ E ++E E+ +G+ E+ E ED +
Sbjct: 647 DEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKL 706
Query: 949 -EEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
+EEE E ++ + G G G EEG
Sbjct: 707 FDEEEDSSEKLFDDSDERGTLGGFGSVEEG 736
Score = 111 bits (277), Expect = 5e-24
Identities = 93/302 (30%), Positives = 146/302 (48%), Gaps = 18/302 (5%)
Query: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG---RG-------E 806
+E + E+ E E EEG E KE E+E ++G E+E EG RG +
Sbjct: 427 DEKKFEKTEDGGEFEEGA---SENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQK 483
Query: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
E EEG V G E + K E +++ + + EE E E+ +E E E +E EE +
Sbjct: 484 ESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDD 543
Query: 867 GEEEGEEGEGEGEEEEG-EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
E+E +E E + E+G E E EE G + +EEG + E + E EE + + E
Sbjct: 544 SEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFE 603
Query: 926 EEGEGEGEEEEG-EGEGEDGEGEGEEEEGEWEG--EEEEGEGEGEEEGEGEGEEGEGEGE 982
++G + +EEG E E ++ E EEEE +E ++E E E EE + +G E +
Sbjct: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663
Query: 983 EEEGEGEGEEEEGEEEGEEEGEGEE-EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
EE E EE +++ +E+ +G+E E E E++ E + EE E ++ +E
Sbjct: 664 EEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDE 723
Query: 1042 EG 1043
G
Sbjct: 724 RG 725
Score = 104 bits (259), Expect = 6e-22
Identities = 97/378 (25%), Positives = 164/378 (43%), Gaps = 44/378 (11%)
Query: 587 PEEKEGAEDSKGNGIEEQEVEANEENVKVHGGR-KEKTEILSDDLTDKAEVSEGKAKSVG 645
PE G S E+ + + H K + + + + + E K +
Sbjct: 376 PEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTE 435
Query: 646 EAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG--EKDKGRGEMERPGEGEKELAEKEEWK 703
+ + EG + +E S ++E E+G EK+ G +R EG E EE
Sbjct: 436 DGGEFEEGASENNAKESSP------EKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGN 489
Query: 704 KRDGEEQEQKEREQGHQKERNQEMEEGGEEE-----HGEGEEEEGDREEEEEKEGEGKEE 758
G E++ ++E + +N E G +E + E EEE G +E EE + E
Sbjct: 490 PVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEK--- 546
Query: 759 GEGEEVEGEREKEEGERKKEERAGKEEKGEEEG--------------DQGEGEEEETEGR 804
E +E E++ E+G ++ E G E+ +EEG ++ + E E E
Sbjct: 547 -ESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
Query: 805 GEEK---EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEE 861
G EK EEG E E +E E+EEEE+ E ++ E+E+ E +E+G +++
Sbjct: 606 GSEKVLDEEGSE---REFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK 662
Query: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
EEG+ +E+ E + E+E+ +G+ E + +E+ E + E + EE+ E
Sbjct: 663 AEEGDADEKLFEESDDKEDEDADGKEVE----DADEKLFEDDDSNEKLFDEEEDSSEKLF 718
Query: 922 EEEGEEGE--GEGEEEEG 937
++ E G G G EEG
Sbjct: 719 DDSDERGTLGGFGSVEEG 736
Score = 102 bits (254), Expect = 2e-21
Identities = 128/532 (24%), Positives = 219/532 (41%), Gaps = 50/532 (9%)
Query: 654 RGDGTC----EEGSSGAEHWQDEEREKGEK---DKGRGEMERPGEGEKELAEKEEWKKRD 706
+GDG C E A DE+ +G K + + +++ + K+ + +++KK+
Sbjct: 181 KGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKL 240
Query: 707 GEEQEQ----KEREQGHQKERNQEMEEGGEEEHGEGEEEEG--------DREEEEEKEGE 754
+Q+Q ER G + R++ + H E++ D E K G+
Sbjct: 241 SMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQ 300
Query: 755 GKE------EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG-----EGEEEETEG 803
++ +G R+ EE + + G+ G + Q + + EET
Sbjct: 301 IRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSR 360
Query: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
EE+ G E E +G R + E G + +E
Sbjct: 361 EREERLRGWEAFLNAPEANRGLRRSDSVSAS--ERAGPSRARHFSEHPSTSKMNAQETAT 418
Query: 864 EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGE-EEGEGEGEEEEGEGKGE 922
EE +E + E E+ GE E EG E +E E E EEG E E EEG K
Sbjct: 419 GMAFEEPIDEKKFEKTEDGGEFE---EGASENNAKESSPEKEAEEGCPEKESEEGCPKRG 475
Query: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG--EGEGEEEGEGEGEEGEG- 979
EG + E EE E+ + E ++ + + EE E E++ E EE G
Sbjct: 476 FEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGP 535
Query: 980 --EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG-EGEEEEEGEV----EGEVEGEEGEG 1032
E EE++ E E +E+ E++ E+ E E E G E + +EEG E ++ E E
Sbjct: 536 TKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEEN 595
Query: 1033 EGEEEEGEEEGEER--EKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSK 1090
+ E E E++G E+ ++EG E + +E+EEEE Y++ ++E++ ++ EEY
Sbjct: 596 DSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKG 655
Query: 1091 IKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ--SKRLLKNGPSGSKKF 1140
++ + K + +K + E V+ ++L ++ S K F
Sbjct: 656 LEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLF 707
Score = 72.8 bits (177), Expect = 2e-12
Identities = 92/361 (25%), Positives = 147/361 (40%), Gaps = 59/361 (16%)
Query: 543 DSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSD--EEVEIPEEKEGAEDSKGNG 600
DS E + + +H S Q T AF + +E + + ++G E +G
Sbjct: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEG-- 443
Query: 601 IEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVG--EAEDGPEGRGD-- 656
A+E N K KE E + +++ G S E+E+G RG
Sbjct: 444 -------ASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEE 496
Query: 657 -------------GTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK-EEW 702
CEE E +D+ ++ E++ G + + EKE E E
Sbjct: 497 DSPKKESKKKTLKNDCEENGLAKES-EDDLNKESEEEVGPTKESEEDDSEKESDEDCSEK 555
Query: 703 KKRDGEEQEQKER-------EQGHQKERNQ-----EMEEGGEEE---HGEGEE----EEG 743
+ DG E+E +E E+G +KE ++ E+EE E +G E EEG
Sbjct: 556 QSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEG 615
Query: 744 DREE--EEEKEGEGKEEGEGEEVEGER-EKEEGERKKEERAGKEEKGEEEGDQGEGEEEE 800
E E+ E E +E+ + + E EKE+ E E+ +K EEGD E EE
Sbjct: 616 SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEE 675
Query: 801 TEGRGEEKEEGGEVEGGE----VEEGKGEREEEEEEGEGEEEEGEGEEE---EGEGEEEE 853
++ + +E +G EVE + ++ E+ +EEE E+ + +E G G EE
Sbjct: 676 SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEE 735
Query: 854 G 854
G
Sbjct: 736 G 736
Score = 35.8 bits (81), Expect = 0.24
Identities = 44/209 (21%), Positives = 85/209 (40%), Gaps = 32/209 (15%)
Query: 451 SERNLQESVLSEQDL----MQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIM 506
SER +E+ L E+DL + E + +LD+ +E + +NS + E ++
Sbjct: 561 SEREFEENGL-EKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEK--------VL 611
Query: 507 SLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566
+E+ +K++++ T ++ D + + D+ E+ E + KA + +
Sbjct: 612 DEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEK 671
Query: 567 IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEIL 626
+F E +EVE +EK +D + N K+ ++ +E L
Sbjct: 672 LFEESDDKEDEDADGKEVEDADEKLFEDD--------------DSNEKLFDEEEDSSEKL 717
Query: 627 SDDLTDKAEVSEGKAKSVGEAEDGPEGRG 655
DD ++ G G E+GP G
Sbjct: 718 FDDSDER-----GTLGGFGSVEEGPLSTG 741
Score = 31.2 bits (69), Expect = 5.9
Identities = 53/232 (22%), Positives = 81/232 (34%), Gaps = 29/232 (12%)
Query: 450 CSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSS--TVESLGETTDILNMTHIMS 507
C E L + SE DL + E + TKE+E D+S + E E
Sbjct: 512 CEENGLAKE--SEDDLNKESEEEV---GPTKESEEDDSEKESDEDCSEKQSEDGSEREFE 566
Query: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI 567
N EK L ++ ++ + E D L END E E + K + S+
Sbjct: 567 ENGLEKDL-----DEEGSEKELHENVLDKELEENDS--ENSEFEDDGSEKVLDEEGSERE 619
Query: 568 FMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILS 627
F DE+ +EKE ED+ +++ E +E G + +
Sbjct: 620 F------------DED---SDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAE 664
Query: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
+ D+ E K +A+ D E E DEE + EK
Sbjct: 665 EGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEK 716
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.300 0.128 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,698,278
Number of Sequences: 37866
Number of extensions: 4210989
Number of successful extensions: 251549
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1609
Number of HSP's successfully gapped in prelim test: 1078
Number of HSP's that attempted gapping in prelim test: 26002
Number of HSP's gapped (non-prelim): 68449
length of query: 1152
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1039
effective length of database: 13,968,660
effective search space: 14513437740
effective search space used: 14513437740
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.