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Search of human proteins with 78000167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
(905 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1820 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 1496 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1463 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1363 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 1314 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1303 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 1217 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 439 e-123
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 399 e-111
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 392 e-109
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 379 e-105
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 357 4e-98
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 340 3e-93
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 302 8e-82
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 283 7e-76
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 283 7e-76
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 271 3e-72
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 105 2e-22
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 100 5e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 100 5e-21
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 100 5e-21
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 93 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 92 2e-18
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 87 9e-17
gi|11321634 CD2-associated protein [Homo sapiens] 82 2e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 82 2e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 82 2e-15
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 82 2e-15
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 3e-15
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 76 1e-13
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1820 bits (4713), Expect = 0.0
Identities = 905/905 (100%), Positives = 905/905 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
Query: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
Query: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
Query: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
Query: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI
Sbjct: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
Query: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL
Sbjct: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
Query: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
Query: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR
Sbjct: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
Query: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL
Sbjct: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
Query: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
Query: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 901 KPLYL 905
KPLYL
Sbjct: 901 KPLYL 905
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 1496 bits (3872), Expect = 0.0
Identities = 786/960 (81%), Positives = 791/960 (82%), Gaps = 149/960 (15%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL------ 114
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 115 -------------------------SSSADANGNAQPSSLAAKGYR-------------- 135
S A ++ AQP + Y
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNR------------- 338
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNR
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 339 ---------------------------------DDDSDLYSPRYSFSEDTKSPLSVPRSK 365
DDDSDLYSPRYSFSEDTKSPLSVPRSK
Sbjct: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
Query: 366 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 425
SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP
Sbjct: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
Query: 426 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 485
GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR
Sbjct: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
Query: 486 K----------------------------------SSAISPTPEISSETPGYIYSSNFHA 511
K SSAISPTPEISSETPGYIYSSNFHA
Sbjct: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
Query: 512 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 571
VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
Sbjct: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
Query: 572 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 631
DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL
Sbjct: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
Query: 632 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 691
LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
Sbjct: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
Query: 692 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 751
IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
Sbjct: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
Query: 752 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHS 811
DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ S HS
Sbjct: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS 960
Score = 168 bits (425), Expect = 2e-41
Identities = 79/79 (100%), Positives = 79/79 (100%)
Query: 827 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 886
QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS
Sbjct: 1214 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 1273
Query: 887 RRTKQFGTFPGNYVKPLYL 905
RRTKQFGTFPGNYVKPLYL
Sbjct: 1274 RRTKQFGTFPGNYVKPLYL 1292
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 839 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 898
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 899 YVKPL 903
Y++ L
Sbjct: 846 YIELL 850
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 639 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
Query: 697 YIELL 701
Y++ L
Sbjct: 1286 YVKPL 1290
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 706 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 762
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 763 TSRQGIFPITYV 774
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1463 bits (3788), Expect = 0.0
Identities = 767/905 (84%), Positives = 771/905 (85%), Gaps = 124/905 (13%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 141
Query: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 142 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 186
Query: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 187 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 246
Query: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 247 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 306
Query: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 307 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE---- 362
Query: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
PK I++Y PG S+L
Sbjct: 363 ---------------------------------------------PKSIYEYQPGKSSVL 377
Query: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
E + SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 378 TNE-KMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 436
Query: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR
Sbjct: 437 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 496
Query: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL
Sbjct: 497 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 556
Query: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 557 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 616
Query: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 617 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 676
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 677 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 716
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 717 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 776
Query: 901 KPLYL 905
KPLYL
Sbjct: 777 KPLYL 781
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1363 bits (3528), Expect = 0.0
Identities = 726/905 (80%), Positives = 730/905 (80%), Gaps = 165/905 (18%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 100
Query: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 101 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 145
Query: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
Query: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 206 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 265
Query: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 266 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE---- 321
Query: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
PK I++Y PG S+L
Sbjct: 322 ---------------------------------------------PKSIYEYQPGKSSVL 336
Query: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
E + SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 337 TNE-KMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
Query: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR
Sbjct: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 455
Query: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL
Sbjct: 456 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 515
Query: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 516 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 575
Query: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 576 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 636 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 675
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 676 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 735
Query: 901 KPLYL 905
KPLYL
Sbjct: 736 KPLYL 740
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 1314 bits (3401), Expect = 0.0
Identities = 717/977 (73%), Positives = 740/977 (75%), Gaps = 171/977 (17%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL------ 114
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 115 -------------------------SSSADANGNAQPSSLAAKGYR-------------- 135
S A ++ AQP + Y
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD-DDSDLYSPRYS 350
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD + + Y P Y
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 351 F---------SEDTKS-PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERND 400
F SE+TKS + PR + + I + ++ P + S ++ + +D
Sbjct: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
Query: 401 WEPP--DKKVDTRKYRAEPKSIYEYQ----------------PGKSS------------- 429
P DT+ + P+S E P +SS
Sbjct: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
Query: 430 --------------------------VLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 463
VLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK
Sbjct: 541 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 600
Query: 464 PPPKKIWDYTPGDCSILPREDRK----------------------------------SSA 489
PPPKKIWDYTPGDCSILPREDRK SSA
Sbjct: 601 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 660
Query: 490 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 549
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 661 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 720
Query: 550 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 609
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA
Sbjct: 721 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
Query: 610 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 669
RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 781 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 840
Query: 670 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 729
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 841 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 900
Query: 730 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 789
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 960
Query: 790 DLPFSSSPSRSATASPQ 806
DLPFSSSPSRSATASPQ
Sbjct: 961 DLPFSSSPSRSATASPQ 977
Score = 198 bits (503), Expect = 2e-50
Identities = 250/928 (26%), Positives = 377/928 (40%), Gaps = 203/928 (21%)
Query: 22 GQDKATADPLRARSISAVKIIPVKTVKNASGLVLPT--DMDPTKICTGKG-AVTLRASSS 78
GQ+ P + V IP T AS L PT D P + + RAS S
Sbjct: 172 GQEGTARPPTPLGPLGCVPTIPA-TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGS 230
Query: 79 Y----RETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGY 134
+ + PS SP P P + ++ R S D G A S+ ++
Sbjct: 231 FAPISQTPPSFSPPPPLV-------------PPAPEDLRRVSEPDLTG-AVSSTDSSPLL 276
Query: 135 RSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVS---E 191
V +L SQ +P S+P+ A S ++ P L+ E +R+S +
Sbjct: 277 NEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVN-------PTIVLLQHNREQQKRLSSLSD 329
Query: 192 PDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPS---VSKPSSAYPSTTIVNPTIVLLQHN 248
P V DS+P + +S + +A V K + ++ I L
Sbjct: 330 PVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTE 389
Query: 249 REQQ------KRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQ 302
R + K++ L+ E E PT + P P I++ +++ V S +
Sbjct: 390 RSKDWYKTMFKQIHKLNRDTPE----ENPYFPTYKFPELP--EIQQTSEETKSCSVMSPR 443
Query: 303 -DLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSV 361
+ S + + L ++ T Q+ DDDSDLYSPRYSFSEDTKSPLSV
Sbjct: 444 LECSGTVIAHCSLKLLDSSNPP----TSASQVAG-TADDDSDLYSPRYSFSEDTKSPLSV 498
Query: 362 PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIY 421
PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 499 PRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE----- 553
Query: 422 EYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILP 481
PK I++Y PG S+L
Sbjct: 554 --------------------------------------------PKSIYEYQPGKSSVLT 569
Query: 482 REDRKSSAISPTPEISSETPGYIYSSNFH----AVKRESDGAPGDL---------TSLEN 528
E + S ISP P Y + S K+ D PGD T+L+
Sbjct: 570 NE-KMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDK 628
Query: 529 ERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPAD---YLESTE-EFIRRR 584
+ + ++ LE ++ L+ K PS++ + SP I ++ Y+ S+ ++R
Sbjct: 629 DLSLCQTELEADLEKMETLN--KAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRE 686
Query: 585 HD----DKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKR 640
D D L +++ K E DI + +G+ T + ++ +
Sbjct: 687 SDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD--------SESPRH 738
Query: 641 KSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP------ 694
++ + +F + KE L D + ++ ++ H G+ P
Sbjct: 739 FIPADYLESTEEFIRRRHDDKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFI 794
Query: 695 --RTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 752
+ +LL + A+ K + E A AKF+F T E+ +KG+ + + +Q+D
Sbjct: 795 TNERFGDLLNIDDTAKRKSGS-----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQID 849
Query: 753 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSL 812
+NWYEG G R GIFP TY+++
Sbjct: 850 QNWYEGEHHG--RVGIFPRTYIEL------------------------------------ 871
Query: 813 RAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 872
L +EK AQ +++TP + + A +++ E+ R G+ +
Sbjct: 872 -----LPPAEK------AQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERIT 917
Query: 873 VMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
++ + D+ W+ G T + G FP YV
Sbjct: 918 LLRQVDENWYEGRIPGTSRQGIFPITYV 945
Score = 196 bits (499), Expect = 6e-50
Identities = 123/271 (45%), Positives = 155/271 (57%), Gaps = 19/271 (7%)
Query: 645 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 702
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 703 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 762
+P PV ++ + T +R+ E R+ + E G
Sbjct: 950 -----RPLVKNPVDYMDL--PFSSSPSRSATASPQPWRE-ESGQYERKAERGAGERGPGG 1001
Query: 763 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS------ATASPQLSHH--SLRA 814
+ DV++ + + ++ P S P + + + Q H +A
Sbjct: 1002 PKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQA 1061
Query: 815 GPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
G S QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 1062 GRKAARRGGSQ-QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
Query: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 839 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 898
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 899 YVKPL 903
Y++ L
Sbjct: 868 YIELL 872
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 639 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 697 YIELL 701
Y++ L
Sbjct: 1145 YVKPL 1149
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1303 bits (3372), Expect = 0.0
Identities = 712/974 (73%), Positives = 721/974 (74%), Gaps = 227/974 (23%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL------ 114
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
Query: 115 -------------------------SSSADANGNAQPSSLAAKGYR-------------- 135
S A ++ AQP + Y
Sbjct: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
Query: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 149 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 208
Query: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 209 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 268
Query: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 269 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 328
Query: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF 351
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF
Sbjct: 329 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF 388
Query: 352 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 411
SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR
Sbjct: 389 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 448
Query: 412 KYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWD 471
KYRAE PK I++
Sbjct: 449 KYRAE-------------------------------------------------PKSIYE 459
Query: 472 YTPGDCSILPREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ 531
Y PG S+L E + SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ
Sbjct: 460 YQPGKSSVLTNE-KMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ 518
Query: 532 IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKL 591
IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 519 IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR--------- 569
Query: 592 LADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARA 651
RRH DD EMRPARA
Sbjct: 570 ------------------RRH----------------------DD-------KEMRPARA 582
Query: 652 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 711
KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK
Sbjct: 583 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 642
Query: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI
Sbjct: 643 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 702
Query: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ QPQAQ
Sbjct: 703 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQ 742
Query: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ
Sbjct: 743 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 802
Query: 892 FGTFPGNYVKPLYL 905
FGTFPGNYVKPLYL
Sbjct: 803 FGTFPGNYVKPLYL 816
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 1217 bits (3148), Expect = 0.0
Identities = 669/905 (73%), Positives = 673/905 (74%), Gaps = 221/905 (24%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 100
Query: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 101 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 145
Query: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
Query: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 206 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 265
Query: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 266 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE---- 321
Query: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
PK I++Y PG S+L
Sbjct: 322 ---------------------------------------------PKSIYEYQPGKSSVL 336
Query: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
E + SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 337 TNE-KMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 395
Query: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 396 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR------------------ 437
Query: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
RRH DD EMRPARAKFDFKAQTL
Sbjct: 438 ---------RRH----------------------DD-------KEMRPARAKFDFKAQTL 459
Query: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 460 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 519
Query: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 520 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 580 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 619
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 620 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 679
Query: 901 KPLYL 905
KPLYL
Sbjct: 680 KPLYL 684
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 439 bits (1130), Expect = e-123
Identities = 301/808 (37%), Positives = 420/808 (51%), Gaps = 171/808 (21%)
Query: 122 GNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPP 181
G S +AKG+RSV PNL +S + + G+ +P+S FSP +P
Sbjct: 4 GRDSQSPDSAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPSAYSLPA 63
Query: 182 APEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPT 241
+ ++ + +S DS+ + + SL GT S + P
Sbjct: 64 S------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIP------------------ 99
Query: 242 IVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKST 301
L + E++KR++ + + P PG
Sbjct: 100 ---LYRSSEEEKRVTVI------------------KAPHYPGIG---------------- 122
Query: 302 QDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKS 357
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +
Sbjct: 123 ------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYN 176
Query: 358 P----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSER 398
P S P +K++ S+ D + A+ P+P +SS+E+
Sbjct: 177 PPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEK 236
Query: 399 NDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSE 458
+DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P++IDL+NEPWYKFFSE
Sbjct: 237 HDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFFSE 296
Query: 459 LEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSETP--GYIYSSNFHAVKRES 516
LEFG+PPPKK DY S + E +S + + S E P +S+F +R+S
Sbjct: 297 LEFGRPPPKKPLDYVQDHSSGVFNE---ASLYQSSIDRSLERPMSSASMASDFRK-RRKS 352
Query: 517 DGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLES 576
+ A G L ++ S G + L G S S ++S+ S S
Sbjct: 353 EPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------ 397
Query: 577 TEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDD 636
R D+E + R ++ + + ER G
Sbjct: 398 -------RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT------ 426
Query: 637 TAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRT 696
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +
Sbjct: 427 -----PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPIS 481
Query: 697 YIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW 755
Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NW
Sbjct: 482 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541
Query: 756 YEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAG 815
YEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S HSL +
Sbjct: 542 YEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN 593
Query: 816 PDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVME 875
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVME
Sbjct: 594 -------------KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVME 638
Query: 876 KCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
KCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 639 KCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 399 bits (1024), Expect = e-111
Identities = 295/850 (34%), Positives = 417/850 (49%), Gaps = 197/850 (23%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
Query: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 85 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 138
Query: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
P L + E++KR++ + + P P
Sbjct: 139 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 159
Query: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR- 338
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 160 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 197
Query: 339 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 388
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 198 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 257
Query: 389 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 439
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 258 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP-P 316
Query: 440 ISPEEIDLKNEPWYKFFSELEFGK------PPPKKIWDYTPGDCSILPREDRKSSAISPT 493
+ + EP K S G+ PPP+ S P ++ A+SPT
Sbjct: 317 LPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR----------SGAPTPSSRAPALSPT 366
Query: 494 PEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 553
K+ D + + NE +Y+S ++ L+RP
Sbjct: 367 ----------------RPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERP 401
Query: 554 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA 609
SSAS +F +RR + + L DQ + D+
Sbjct: 402 MSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 444
Query: 610 ------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFD 654
+ T P+ + L ++ +A R+ E PA+A +D
Sbjct: 445 SSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYD 504
Query: 655 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP 714
FKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P
Sbjct: 505 FKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPP 564
Query: 715 -VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITY 773
Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++Y
Sbjct: 565 PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 624
Query: 774 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQR 833
V+V+K+ K DY D P S S HSL + + Q+
Sbjct: 625 VEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQRP 663
Query: 834 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 893
T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FG
Sbjct: 664 VFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFG 721
Query: 894 TFPGNYVKPL 903
TFPGNYVK L
Sbjct: 722 TFPGNYVKRL 731
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 392 bits (1007), Expect = e-109
Identities = 292/827 (35%), Positives = 407/827 (49%), Gaps = 204/827 (24%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
Query: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 68 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 121
Query: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
P L + E++KR++ + + P P
Sbjct: 122 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 142
Query: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR- 338
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 143 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 180
Query: 339 DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPAR 388
DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 181 DDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP 240
Query: 389 SSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRD 439
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 241 HVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER---- 296
Query: 440 ISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSE 499
PPPKK DY S + E +S + + S E
Sbjct: 297 ------------------------PPPKKPLDYVQDHSSGVFNE---ASLYQSSIDRSLE 329
Query: 500 TP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 557
P +S+F +R+S+ A G L ++ S G + L G S S ++
Sbjct: 330 RPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTS 385
Query: 558 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 617
S+ S S R D+E + R ++ +
Sbjct: 386 SSPSSPS-------------------RAKDRE------------------SPRSYSSTLT 408
Query: 618 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 677
+ ER G E PA+A +DFKAQT KEL +KGD VYI ++I
Sbjct: 409 DMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 457
Query: 678 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVE 736
DQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE
Sbjct: 458 DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVE 517
Query: 737 MSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSS 796
+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S
Sbjct: 518 LSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHS 576
Query: 797 PSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYI 856
S HSL + + Q+ T + Q + F QALY+Y
Sbjct: 577 YSSDRI-------HSLSSN-------------KPQRPVFTHENIQGGGEPF--QALYNYT 614
Query: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 615 PRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 379 bits (972), Expect = e-105
Identities = 254/666 (38%), Positives = 355/666 (53%), Gaps = 127/666 (19%)
Query: 289 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 342
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 343 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 392
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
Query: 393 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPE 443
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +
Sbjct: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPP-PLPTT 413
Query: 444 EIDLKNEPWYKFFSELEFGK------PPPKKIWDYTPGDCSILPREDRKSSAISPTPEIS 497
+ EP K S G+ PPP+ S P ++ A+SPT
Sbjct: 414 PTPVPREPGRKPLSSSRLGEVTGSPSPPPR----------SGAPTPSSRAPALSPT---- 459
Query: 498 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 557
K+ D + + NE +Y+S ++ L+RP SSA
Sbjct: 460 ------------RPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSA 498
Query: 558 STKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA---- 609
S +F +RR + + L DQ + D+
Sbjct: 499 SM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTT 541
Query: 610 --RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQ 658
+ T P+ + L ++ +A R+ E PA+A +DFKAQ
Sbjct: 542 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQ 601
Query: 659 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQV 717
T KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 602 TSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQP 661
Query: 718 LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+
Sbjct: 662 GEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
Query: 778 KRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTP 837
K+ K DY D P S S HSL + + Q+ T
Sbjct: 722 KKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQRPVFTH 760
Query: 838 DRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 897
+ Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPG
Sbjct: 761 ENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPG 818
Query: 898 NYVKPL 903
NYVK L
Sbjct: 819 NYVKRL 824
Score = 33.5 bits (75), Expect = 0.92
Identities = 108/582 (18%), Positives = 199/582 (34%), Gaps = 106/582 (18%)
Query: 153 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 197
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 316 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 375
Query: 198 VSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 257
D+ +E S ++ + P+T PT V + R+
Sbjct: 376 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT----PTPVPREPGRK------- 424
Query: 258 LSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVG 313
P+S R+GE +P+ PT +A ++ + QD S +E
Sbjct: 425 ---PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEAS 481
Query: 314 IPLRNTERS--KDWYKTMFKQIHKLNRDDDSDLYSPR----YSFSEDTKSPLSVPRSKSE 367
+ + +RS + + R + + PR S S + + +P S +
Sbjct: 482 LYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTT 541
Query: 368 MSYIDGEKVVKRSATLPLPA--RSSSLKSSSERNDW---EPPDKKVDTRKYRAEPKSIYE 422
++ + S + P A R S SS D P +++ K + K++Y+
Sbjct: 542 LT----KSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYD 597
Query: 423 YQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPR 482
++ S L+ +K +ID + WY+ G P + TP
Sbjct: 598 FKAQTSKELSFKKGDTVYILRKID---QNWYEGEHHGRVGIFPISYVEKLTP-------- 646
Query: 483 EDRKSSAISPTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSLENERQIYKSVLEGGD 541
++ A P P E I NF+A E GD L +++ ++ E G
Sbjct: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVIL--LKRVDQNWYE-GK 703
Query: 542 IPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKRE 601
IP G+ P Y+E ++ + D + + R
Sbjct: 704 IPGTNRQGI------------------FPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRI 745
Query: 602 QEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLK 661
+++ + + TH + G E P +A +++ +
Sbjct: 746 H---SLSSNKPQRPVFTHENI------------------QGGGE--PFQALYNYTPRNED 782
Query: 662 ELPLQKGDIVYIYKQIDQNWYEGEHHGR--VGIFPRTYIELL 701
EL L++ D++ + ++ D W+ G G FP Y++ L
Sbjct: 783 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 357 bits (915), Expect = 4e-98
Identities = 281/815 (34%), Positives = 382/815 (46%), Gaps = 214/815 (26%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSF 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S + + G+
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
Query: 163 APISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 222
+P+S FSP +P + ++ + +S DS+ + + SL GT S +
Sbjct: 85 SPMSYYQRPFSPSAYSLPAS------LNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSI 138
Query: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
P L + E++KR++ + + P P
Sbjct: 139 P---------------------LYRSSEEEKRVTVI------------------KAPHYP 159
Query: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRD 339
G +DE GIP +R T +R KDWYKTMFKQIH +++
Sbjct: 160 GIG----------------------PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKP 197
Query: 340 DDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSS 391
LY+P YS T PLS S S ++ D V P+P
Sbjct: 198 G---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPR 254
Query: 392 LKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEP 451
+SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 255 DRSSTEKHDWDPPDRKVDTRKFRSE----------------------------------- 279
Query: 452 WYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSETP--GYIYSSNF 509
P+ I++Y PG SIL E R +S + + S E P +S+F
Sbjct: 280 --------------PRSIFEYEPGKSSILQHE-RPASLYQSSIDRSLERPMSSASMASDF 324
Query: 510 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 569
+R+S+ A G L ++ S G + L G S S ++S+ S S
Sbjct: 325 RK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS----- 375
Query: 570 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 629
R D+E + R ++ + + ER G
Sbjct: 376 --------------RAKDRE------------------SPRSYSSTLTDMGRSAPRERRG 403
Query: 630 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGR
Sbjct: 404 T-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGR 452
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLL 748
VGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL
Sbjct: 453 VGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILL 512
Query: 749 RQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLS 808
++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 513 KRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI------ 565
Query: 809 HHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 868
HSL + + Q+ T + Q + F QALY+Y P+N+DELELR+
Sbjct: 566 -HSLSSN-------------KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRES 609
Query: 869 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 610 DVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 340 bits (873), Expect = 3e-93
Identities = 231/612 (37%), Positives = 314/612 (51%), Gaps = 148/612 (24%)
Query: 315 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 368
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 369 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 414
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
Query: 415 AEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTP 474
+E P+ I++Y P
Sbjct: 126 SE-------------------------------------------------PRSIFEYEP 136
Query: 475 GDCSILPREDRKSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQI 532
G SIL E R +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 137 GKSSILQHE-RPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA- 193
Query: 533 YKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLL 592
S G + L G S S ++S+ S S R D+E
Sbjct: 194 --SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE--- 229
Query: 593 ADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 652
+ R ++ + + ER G E PA+A
Sbjct: 230 ---------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAV 263
Query: 653 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKL 712
+DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP +
Sbjct: 264 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 323
Query: 713 TP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP+
Sbjct: 324 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPV 383
Query: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
+YV+V+K+ K DY D P S S HSL + + Q
Sbjct: 384 SYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------------KPQ 422
Query: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
Query: 892 FGTFPGNYVKPL 903
FGTFPGNYVK L
Sbjct: 481 FGTFPGNYVKRL 492
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 302 bits (774), Expect = 8e-82
Identities = 224/661 (33%), Positives = 308/661 (46%), Gaps = 146/661 (22%)
Query: 291 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLYSP 347
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLD---- 164
Query: 348 RYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKK 407
++F E + P + + R A P PA SSS +S W+ ++
Sbjct: 165 -WTFEEPPRDPRHLGAQQ-------------RPAHRPGPATSSSGRS------WDHSEEL 204
Query: 408 VDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEID--LKNEPWYKFFSELEFGKPP 465
P+S + Y+PG S + E++D E W +F ELE G+ P
Sbjct: 205 ---------PRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRP 255
Query: 466 PKKIWDYTPGDCSILPREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTS 525
K + D PG+ P E ++ E+S+E DL +
Sbjct: 256 KKPLVD-DPGEKPSQPIEVLLERELA---ELSAELDK-------------------DLRA 292
Query: 526 LENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRH 585
+E KS P Q + P+ AS S P A YL S +
Sbjct: 293 IETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH----APYLGSARSLSPHKM 343
Query: 586 DDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSE 645
D +R D +A G + R+ +
Sbjct: 344 ADGGSPFLGRRDFVYPSSTRDPSASNGGG----------------------SPARREEKK 381
Query: 646 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 705
+ AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E
Sbjct: 382 RKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADE 441
Query: 706 KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 765
+P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT R
Sbjct: 442 IPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGR 501
Query: 766 QGIFPITYVDVIKRP-------------------------------LVKNPVDYMDLPFS 794
QGIFP +YV V + P +++P D +DL
Sbjct: 502 QGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQ 561
Query: 795 SSPSRSA----TASPQLSHHSL-RAGPDLTES-------EKSYVQPQAQQRRVTPDRSQT 842
+SP R+ T P+ +L GP L+ S + P Q TP
Sbjct: 562 TSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTP----- 616
Query: 843 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 902
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P
Sbjct: 617 ------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Query: 903 L 903
+
Sbjct: 671 V 671
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 283 bits (723), Expect = 7e-76
Identities = 148/260 (56%), Positives = 181/260 (69%), Gaps = 24/260 (9%)
Query: 645 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 704
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
Query: 705 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 764 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEK 823
+RQGIFP++YV+V+K+ K DY D P S S HSL +
Sbjct: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------- 931
Query: 824 SYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 932 -----KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 984
Query: 884 GTSRRTKQFGTFPGNYVKPL 903
GTSRRTK FGTFPGNYVK L
Sbjct: 985 GTSRRTKFFGTFPGNYVKRL 1004
Score = 106 bits (265), Expect = 9e-23
Identities = 58/129 (44%), Positives = 81/129 (62%), Gaps = 11/129 (8%)
Query: 315 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 367
PL+ +R KDWYKTMFKQIH +++ LY+P YS T PLS S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
Query: 368 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 426
++ D V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 63 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 427 KSSVLTNEK 435
KSS+L +E+
Sbjct: 123 KSSILQHER 131
Score = 75.5 bits (184), Expect = 2e-13
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 51/208 (24%)
Query: 694 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 753
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 754 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLR 813
NWYEG G R GIFPI+YV+ + + P ++ A P
Sbjct: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARP-------- 835
Query: 814 AGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 873
P AQ ++ A Y++ + EL LR GD V +
Sbjct: 836 -------------PPPAQ-----------PGEIGEAIAKYNFNADTNVELSLRKGDRVIL 871
Query: 874 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
+++ D W+ G T + G FP +YV+
Sbjct: 872 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
Score = 44.3 bits (103), Expect = 5e-04
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 6/140 (4%)
Query: 766 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
Q + P+ I P +N D +P S+S TA+ H ES +SY
Sbjct: 689 QPLHPLPPDGAIHCPPYQN--DCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSY 746
Query: 826 VQPQAQQRRVTPD--RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
R P R ++ +A+Y + Q EL + GD V ++ K D W+
Sbjct: 747 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 806
Query: 884 GTSRRTKQFGTFPGNYVKPL 903
G + G FP +YV+ L
Sbjct: 807 G--EHHGRVGIFPISYVEKL 824
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 283 bits (723), Expect = 7e-76
Identities = 148/260 (56%), Positives = 181/260 (69%), Gaps = 24/260 (9%)
Query: 645 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 704
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
Query: 705 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 764 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEK 823
+RQGIFP++YV+V+K+ K DY D P S S HSL +
Sbjct: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRI-------HSLSSN-------- 1027
Query: 824 SYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFV
Sbjct: 1028 -----KPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFV 1080
Query: 884 GTSRRTKQFGTFPGNYVKPL 903
GTSRRTK FGTFPGNYVK L
Sbjct: 1081 GTSRRTKFFGTFPGNYVKRL 1100
Score = 114 bits (285), Expect = 4e-25
Identities = 67/172 (38%), Positives = 107/172 (62%), Gaps = 25/172 (14%)
Query: 289 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 342
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 343 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 392
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
Query: 393 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 435
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 227
Score = 75.5 bits (184), Expect = 2e-13
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 51/208 (24%)
Query: 694 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 753
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 754 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLR 813
NWYEG G R GIFPI+YV+ + + P ++ A P
Sbjct: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARP-------- 931
Query: 814 AGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 873
P AQ ++ A Y++ + EL LR GD V +
Sbjct: 932 -------------PPPAQ-----------PGEIGEAIAKYNFNADTNVELSLRKGDRVIL 967
Query: 874 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
+++ D W+ G T + G FP +YV+
Sbjct: 968 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
Score = 44.3 bits (103), Expect = 5e-04
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 6/140 (4%)
Query: 766 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
Q + P+ I P +N D +P S+S TA+ H ES +SY
Sbjct: 785 QPLHPLPPDGAIHCPPYQN--DCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSY 842
Query: 826 VQPQAQQRRVTPD--RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 883
R P R ++ +A+Y + Q EL + GD V ++ K D W+
Sbjct: 843 SSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE 902
Query: 884 GTSRRTKQFGTFPGNYVKPL 903
G + G FP +YV+ L
Sbjct: 903 G--EHHGRVGIFPISYVEKL 920
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 271 bits (692), Expect = 3e-72
Identities = 146/307 (47%), Positives = 188/307 (61%), Gaps = 54/307 (17%)
Query: 640 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 699
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 700 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 759
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 760 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 788
I GT RQGIFP +YV V + P +++P D
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
Query: 789 MDLPFSSSPSRSA----TASPQLSHHSL-RAGPDLTES-------EKSYVQPQAQQRRVT 836
+DL +SP R+ T P+ +L GP L+ S + P Q T
Sbjct: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
Query: 837 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 896
P Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFP
Sbjct: 274 P-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFP 322
Query: 897 GNYVKPL 903
GNYV P+
Sbjct: 323 GNYVAPV 329
Score = 38.9 bits (89), Expect = 0.022
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 632 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 689
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
Query: 690 VGIFPRTYI 698
G FP Y+
Sbjct: 318 FGTFPGNYV 326
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 105 bits (262), Expect = 2e-22
Identities = 87/323 (26%), Positives = 137/323 (42%), Gaps = 79/323 (24%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 709 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 764
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 765 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATA-------------- 803
+ GIFPI +V+ ++++ + +L SS SR T+
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 804 ----------------SPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDR-------- 839
SP H + P L S V Q ++ P
Sbjct: 298 QFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQVSTY 357
Query: 840 ------------------SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGW 881
SQ + AL+SY DEL+L+ G+ V V+ KC DGW
Sbjct: 358 HPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGW 417
Query: 882 FVGTSRRTKQFGTFPGNYVKPLY 904
G S T + G FP NYV P++
Sbjct: 418 LRGVSLVTGRVGIFPNNYVIPIF 440
Score = 34.7 bits (78), Expect = 0.41
Identities = 28/105 (26%), Positives = 45/105 (42%), Gaps = 9/105 (8%)
Query: 724 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 783
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKT-- 443
Query: 784 NPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQP 828
P S SP T + LS S+ + ++E + +P
Sbjct: 444 -----SSFPDSRSPGLYTTWT--LSTSSVSSQGSISEGDPRQSRP 481
Score = 33.9 bits (76), Expect = 0.70
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 5/87 (5%)
Query: 818 LTESEKSYVQP---QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
L + KS P QA R+ P+ + +AL +Y QN +L GDI+ +
Sbjct: 96 LQDGRKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLR 155
Query: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVK 901
+ D+ W+ G G FP + V+
Sbjct: 156 RQLDENWYQGEINGIS--GNFPASSVE 180
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 100 bits (250), Expect = 5e-21
Identities = 74/289 (25%), Positives = 129/289 (44%), Gaps = 41/289 (14%)
Query: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 772 TYVDVIK------RPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
+V+ ++ ++ V S + + P +L + T + S+
Sbjct: 564 NFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 623
Query: 826 VQPQAQQ--RRVTPD----RSQTSQDLF-----------------------SYQALYSYI 856
+ Q R+ D R Q + +F +ALY +
Sbjct: 624 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFR 683
Query: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
+N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 684 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
Query: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
VD++W G + G S GIFP Y+ ++
Sbjct: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/243 (23%), Positives = 101/243 (41%), Gaps = 58/243 (23%)
Query: 667 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 721
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 722 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
+D+P + R +S H ++ +
Sbjct: 494 --------IDIPEGGNGKRECVSS-----HCVKGSRCV---------------------- 518
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V
Sbjct: 519 ----------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFV 566
Query: 901 KPL 903
+P+
Sbjct: 567 EPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 100 bits (250), Expect = 5e-21
Identities = 74/289 (25%), Positives = 129/289 (44%), Gaps = 41/289 (14%)
Query: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
Query: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
Query: 772 TYVDVIK------RPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
+V+ ++ ++ V S + + P +L + T + S+
Sbjct: 600 NFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 659
Query: 826 VQPQAQQ--RRVTPD----RSQTSQDLF-----------------------SYQALYSYI 856
+ Q R+ D R Q + +F +ALY +
Sbjct: 660 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFR 719
Query: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
+N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 720 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
Query: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
VD++W G + G S GIFP Y+ ++
Sbjct: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/243 (23%), Positives = 101/243 (41%), Gaps = 58/243 (23%)
Query: 667 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 721
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 722 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
Query: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
+D+P + R +S H ++ +
Sbjct: 530 --------IDIPEGGNGKRECVSS-----HCVKGSRCV---------------------- 554
Query: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V
Sbjct: 555 ----------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFV 602
Query: 901 KPL 903
+P+
Sbjct: 603 EPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 100 bits (250), Expect = 5e-21
Identities = 74/289 (25%), Positives = 129/289 (44%), Gaps = 41/289 (14%)
Query: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
Query: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
Query: 772 TYVDVIK------RPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSY 825
+V+ ++ ++ V S + + P +L + T + S+
Sbjct: 623 NFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 682
Query: 826 VQPQAQQ--RRVTPD----RSQTSQDLF-----------------------SYQALYSYI 856
+ Q R+ D R Q + +F +ALY +
Sbjct: 683 KRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFR 742
Query: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
+N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 743 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
Query: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
VD++W G + G S GIFP Y+ ++
Sbjct: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
Score = 64.7 bits (156), Expect = 4e-10
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 58/259 (22%)
Query: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 707
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
Query: 708 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 764
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
Query: 765 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKS 824
+ GIFP YV VI +D+P + R +S H ++ +
Sbjct: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS-----HCVKGSRCV------ 577
Query: 825 YVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 884
A + YI + DEL +G+I+ + E ++ W G
Sbjct: 578 --------------------------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG 611
Query: 885 TSRRTKQFGTFPGNYVKPL 903
R + G FP N+V+P+
Sbjct: 612 EVR--GRTGIFPLNFVEPV 628
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 92.8 bits (229), Expect = 1e-18
Identities = 58/182 (31%), Positives = 93/182 (51%), Gaps = 29/182 (15%)
Query: 722 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 781
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 782 VKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQ 841
K+P+ +P+ H + +G L SE + +RR
Sbjct: 61 KKDPL--------------TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRR----- 101
Query: 842 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Q +SY+PQNDDELEL+ GDI++V+ + ++GW+ G + G FP N++K
Sbjct: 102 ------RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIK 153
Query: 902 PL 903
L
Sbjct: 154 EL 155
Score = 81.3 bits (199), Expect = 4e-15
Identities = 82/332 (24%), Positives = 133/332 (40%), Gaps = 80/332 (24%)
Query: 646 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 701
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 702 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 740
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 741 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 800
G+ I ++ +V+E W+EG + G + G+FP ++ + + + D S S R
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGIS-QDEQLSKSSLRE 177
Query: 801 ATASP------------------------------------------QLSHHSLRAGPDL 818
T S +L S+ D
Sbjct: 178 TTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDF 237
Query: 819 TESEKSYVQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELELRDGDIVDV 873
EK+ + + TPD S+T D + + ++ Y QNDDEL +++GDIV +
Sbjct: 238 LPVEKT-IGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTL 296
Query: 874 MEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 903
+ K D GW+ G + G FP N+VK L
Sbjct: 297 INKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 55.1 bits (131), Expect = 3e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 653 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 707
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 708 QPKKLTP 714
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 92.4 bits (228), Expect = 2e-18
Identities = 84/274 (30%), Positives = 124/274 (45%), Gaps = 32/274 (11%)
Query: 650 RAKFDF----KAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 705
+A +DF K Q L K +I+ + +++D+NW EG ++GIFP Y+EL A+
Sbjct: 262 KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAK 321
Query: 706 KA-QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG-- 762
+ + K P ++ D+ S ++ V ++ R+ G
Sbjct: 322 QLIEMDKPCPAAASSCNASLPS-----DSGAVASVAPSPTLSSSGAVSA--FQRRVDGKK 374
Query: 763 -TSRQGIFPITYVDVIKRPL-VKNPVDYMDLP----FSSSPSRSATASPQLSHHSLRAGP 816
T ++ F T + V R + M++ SSS R+A L+H S A P
Sbjct: 375 NTKKRHSF--TALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSC-AAP 431
Query: 817 DLTESEKSYVQPQAQQRRV-------TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 869
S + P A R TP + Q ++ Y ALY+Y PQ DELEL G+
Sbjct: 432 TQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGE 489
Query: 870 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
+ V+EKC DGWF G S RT G FPGNYV P+
Sbjct: 490 MYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 88.6 bits (218), Expect = 2e-17
Identities = 63/205 (30%), Positives = 101/205 (49%), Gaps = 21/205 (10%)
Query: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 709
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 710 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 767
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 768 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQ 827
IFP+ YV++ K ++ MD P ++ S + P S P T S V
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAV- 363
Query: 828 PQAQQRRVTPDRSQTSQDLFSYQAL 852
A QRRV D + ++ S+ AL
Sbjct: 364 -SAFQRRV--DGKKNTKKRHSFTAL 385
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/53 (47%), Positives = 40/53 (75%)
Query: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 828 YRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 699
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/162 (25%), Positives = 59/162 (36%), Gaps = 27/162 (16%)
Query: 701 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 759
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 760 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 802
T G+FP YV + R PL K M P S S S AT
Sbjct: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564
Query: 803 A--------SPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVT 836
A +PQ A P + QP A Q R T
Sbjct: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARST 606
Score = 35.8 bits (81), Expect = 0.19
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
Score = 33.1 bits (74), Expect = 1.2
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 733 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 775
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 86.7 bits (213), Expect = 9e-17
Identities = 71/263 (26%), Positives = 117/263 (44%), Gaps = 47/263 (17%)
Query: 655 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 713
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 714 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 764 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTES 821
+ G FP +V+++ P + NP D+P S + PQ P L S
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRP-------PKL--S 166
Query: 822 EKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DD 879
+Y P PD QT Y+ L+ Y P+ DEL LR GD+V V+ K D
Sbjct: 167 SLAYDSP--------PDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDK 218
Query: 880 GWFVGTSRRTKQFGTFPGNYVKP 902
GW+ G + + G FP N+V P
Sbjct: 219 GWWEGECQGRR--GVFPDNFVLP 239
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/177 (26%), Positives = 86/177 (48%), Gaps = 30/177 (16%)
Query: 647 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 703
R + F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP ++ELL PP
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 704 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 742
+ +P KL+ +Q + + E F++ + E++ R+G
Sbjct: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
Query: 743 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 797
+ + +L + D+ W+EG G R+G+FP + V+ P +K V + S+P
Sbjct: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAP 258
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/77 (33%), Positives = 47/77 (61%), Gaps = 4/77 (5%)
Query: 827 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 886
+P+ +RR P + Q +SY P+ DEL+L+ G+IV+++++ +DGW++G
Sbjct: 68 RPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG-- 123
Query: 887 RRTKQFGTFPGNYVKPL 903
++ Q G FP N+V+ L
Sbjct: 124 KKNGQLGAFPSNFVELL 140
Score = 40.8 bits (94), Expect = 0.006
Identities = 104/531 (19%), Positives = 197/531 (37%), Gaps = 88/531 (16%)
Query: 40 KIIPVKTVKNASGLVLPTDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESK 99
K++P K V S + +P K+ T++ ++ PS + S +R +
Sbjct: 245 KLVPRKVVSRESAPI----KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKL 300
Query: 100 PGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARAS 159
+ P+ + + G+ P +K ++ S + + HS P +A
Sbjct: 301 TSRDSGPNGGFQ--------SGGSYHPGRKRSKTQTPQQRSVSSQEEE----HSSPVKAP 348
Query: 160 GSFAPISQTPPSFSPPPPLVPPAPEDL---RRVSEPDLTGAVSSTDSSPLLNEVSSSLIG 216
+ +TP P PPAPE+ +++ PD V S + + L + +S
Sbjct: 349 S----VKRTPMPDKTATPERPPAPENAPSSKKIPAPD---KVPSPEKTLTLGDKASIPGN 401
Query: 217 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 276
+ S P+ K + P + + N + ++ P + RV + +P
Sbjct: 402 STSGKIPAPDKVPT--PEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPAL 459
Query: 277 EKPTSPGKAIEKRAK--DDSRRVVK-STQDLSDVSM---DEVGIPLRNTERSKDWYKTMF 330
E P K A D++ + K T +LS+ + D++ ++E + K
Sbjct: 460 EAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYF- 518
Query: 331 KQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEM--SYIDGEKVVKRSATLPLPAR 388
+ K + + ++P P S R EM + + G+ +++ PA
Sbjct: 519 --VAKEDPSSQEEAHTP----EAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPAS 572
Query: 389 SSSLKSSSERND-----WEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPE 443
+L+ + E P T + A P E +P + VL E ++ S E
Sbjct: 573 RPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPN---EQRPLREEVLPKEGVA---SKE 626
Query: 444 EIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPRED---------RKSSAISPTP 494
E+ LK E PPK+ + P+E+ +K+ I P P
Sbjct: 627 EVTLKEE-------------LPPKE---------EVAPKEEVPPIERAFAQKTRPIKPPP 664
Query: 495 EISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQ 545
+ S ET + + +++G D+TSL E + + LE ++ L+
Sbjct: 665 D-SQETLALPSLVPQNYTENKNEGV--DVTSLRGEVESLRRALELMEVQLE 712
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 82.0 bits (201), Expect = 2e-15
Identities = 57/184 (30%), Positives = 95/184 (51%), Gaps = 27/184 (14%)
Query: 724 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 782
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
Query: 783 KNPVDYMD--LPFSSSPSRSATASPQ-LSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDR 839
++ D LP + + Q +S + L AG +QP Q + +
Sbjct: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGG---------IQPHPQTKNIKKKT 108
Query: 840 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 899
+ + L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+
Sbjct: 109 KKRQ-----CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNF 161
Query: 900 VKPL 903
VK L
Sbjct: 162 VKEL 165
Score = 53.9 bits (128), Expect = 7e-07
Identities = 71/312 (22%), Positives = 129/312 (41%), Gaps = 50/312 (16%)
Query: 596 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 650
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
Query: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 710
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
Query: 711 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 770
+V + GE D++ ++ I L V E G + T + I
Sbjct: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
Query: 771 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQA 830
I + D+ K VK L +S S + P+ P + +S + P+
Sbjct: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPE--------KPLILQS----LGPKT 254
Query: 831 QQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSR 887
Q +T ++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G
Sbjct: 255 QSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELN 314
Query: 888 RTKQFGTFPGNY 899
+ G FP N+
Sbjct: 315 GKE--GVFPDNF 324
Score = 36.6 bits (83), Expect = 0.11
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 846 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 903
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
Score = 35.8 bits (81), Expect = 0.19
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 707
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
Query: 708 QPKKLTP 714
PK P
Sbjct: 335 FPKPKKP 341
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/300 (27%), Positives = 122/300 (40%), Gaps = 67/300 (22%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 705
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 876 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 934
Query: 706 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 758
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 935 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 993
Query: 759 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSH--------- 809
I R GIFP YV P D S+S S ++ P+++
Sbjct: 994 SI--GDRSGIFPSNYV---------KPKDQESFG-SASKSGASNKKPEIAQVTSAYVASG 1041
Query: 810 -HSLRAGPD-----LTESEKSYVQPQAQQR----------------------RVTPDRSQ 841
L P L ++ + Q + Q R R TP
Sbjct: 1042 SEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1101
Query: 842 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Q + A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1102 VCQVI----AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1155
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 637 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 689
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1077 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1131
Query: 750 QVDENWYEGRIPGTSRQGIFPITYV 774
+ D +W++G I G + G+FP YV
Sbjct: 1132 KDDPDWWQGEINGVT--GLFPSNYV 1154
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/392 (21%), Positives = 139/392 (35%), Gaps = 127/392 (32%)
Query: 578 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 637
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 678 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 724
Query: 638 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 695
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 725 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 783
Query: 696 TYIE----------------LLPPA----------------------------------- 704
Y+E LLPP
Sbjct: 784 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 843
Query: 705 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 750
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 844 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 903
Query: 751 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHH 810
ENW+ G + G +G FP +YV +I VK
Sbjct: 904 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKRE------------------------- 935
Query: 811 SLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI 870
E E Y A ++ T ++ Y ALY Y +L +G+
Sbjct: 936 ---------EPEALYA---AVNKKPTSAAYSVGEE---YIALYPYSSVEPGDLTFTEGEE 980
Query: 871 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 902
+ V +K + W R+ G FP NYVKP
Sbjct: 981 ILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1009
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Query: 818 LTESEKSYVQPQAQQR---RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
+ E E+ + Q + + + + +T+ L +Y+ALY + +N DE+ GDI+ V
Sbjct: 701 IQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVD 760
Query: 875 EKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 903
EK + GW G+ + FG FP NYV+ +
Sbjct: 761 EKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 789
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/300 (27%), Positives = 122/300 (40%), Gaps = 67/300 (22%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 705
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 706 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 758
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 759 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSH--------- 809
I R GIFP YV P D S+S S ++ P+++
Sbjct: 1021 SI--GDRSGIFPSNYV---------KPKDQESFG-SASKSGASNKKPEIAQVTSAYVASG 1068
Query: 810 -HSLRAGPD-----LTESEKSYVQPQAQQR----------------------RVTPDRSQ 841
L P L ++ + Q + Q R R TP
Sbjct: 1069 SEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1128
Query: 842 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Q + A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1129 VCQVI----AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 637 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 689
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 750 QVDENWYEGRIPGTSRQGIFPITYV 774
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/392 (21%), Positives = 139/392 (35%), Gaps = 127/392 (32%)
Query: 578 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 637
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 638 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 695
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 696 TYIE----------------LLPPA----------------------------------- 704
Y+E LLPP
Sbjct: 811 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 870
Query: 705 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 750
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 871 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 930
Query: 751 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHH 810
ENW+ G + G +G FP +YV +I VK
Sbjct: 931 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKRE------------------------- 962
Query: 811 SLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI 870
E E Y A ++ T ++ Y ALY Y +L +G+
Sbjct: 963 ---------EPEALYA---AVNKKPTSAAYSVGEE---YIALYPYSSVEPGDLTFTEGEE 1007
Query: 871 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 902
+ V +K + W R+ G FP NYVKP
Sbjct: 1008 ILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Query: 818 LTESEKSYVQPQAQQR---RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
+ E E+ + Q + + + + +T+ L +Y+ALY + +N DE+ GDI+ V
Sbjct: 728 IQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVD 787
Query: 875 EKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 903
EK + GW G+ + FG FP NYV+ +
Sbjct: 788 EKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 816
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/300 (27%), Positives = 122/300 (40%), Gaps = 67/300 (22%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 705
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 706 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 758
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 759 RIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSH--------- 809
I R GIFP YV P D S+S S ++ P+++
Sbjct: 1021 SI--GDRSGIFPSNYV---------KPKDQESFG-SASKSGASNKKPEIAQVTSAYVASG 1068
Query: 810 -HSLRAGPD-----LTESEKSYVQPQAQQR----------------------RVTPDRSQ 841
L P L ++ + Q + Q R R TP
Sbjct: 1069 SEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP 1128
Query: 842 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Q + A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1129 VCQVI----AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 637 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 689
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 750 QVDENWYEGRIPGTSRQGIFPITYV 774
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/392 (21%), Positives = 139/392 (35%), Gaps = 127/392 (32%)
Query: 578 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 637
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 638 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 695
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 696 TYIE----------------LLPPA----------------------------------- 704
Y+E LLPP
Sbjct: 811 NYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVN 870
Query: 705 ----------EKAQPKKLTPV----QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQ 750
P ++P+ QV+E +A A ++ ++F K + IT+L Q
Sbjct: 871 TSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ 930
Query: 751 VDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHH 810
ENW+ G + G +G FP +YV +I VK
Sbjct: 931 -QENWWFGEVHGG--RGWFPKSYVKIIPGSEVKRE------------------------- 962
Query: 811 SLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI 870
E E Y A ++ T ++ Y ALY Y +L +G+
Sbjct: 963 ---------EPEALYA---AVNKKPTSAAYSVGEE---YIALYPYSSVEPGDLTFTEGEE 1007
Query: 871 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 902
+ V +K + W R+ G FP NYVKP
Sbjct: 1008 ILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Query: 818 LTESEKSYVQPQAQQR---RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
+ E E+ + Q + + + + +T+ L +Y+ALY + +N DE+ GDI+ V
Sbjct: 728 IQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVD 787
Query: 875 EKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 903
EK + GW G+ + FG FP NYV+ +
Sbjct: 788 EKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 816
Score = 45.8 bits (107), Expect = 2e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 81.6 bits (200), Expect = 3e-15
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 23/169 (13%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 709 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 764
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 765 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQLS 808
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ S
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHS 293
Score = 74.3 bits (181), Expect = 5e-13
Identities = 31/55 (56%), Positives = 39/55 (70%)
Query: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 903
Y A+Y Y P+ +DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 450 YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 59.3 bits (142), Expect = 2e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 849 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 644 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
Query: 697 YIE 699
++E
Sbjct: 884 FVE 886
Score = 38.9 bits (89), Expect = 0.022
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 724 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 783
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 784 NPVDYMDLPFSSSPSRSAT 802
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 35.4 bits (80), Expect = 0.24
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 662 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 698
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 850 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 903
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 4.6
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 733 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 777
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 76.3 bits (186), Expect = 1e-13
Identities = 73/305 (23%), Positives = 128/305 (41%), Gaps = 64/305 (20%)
Query: 649 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 707
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 708 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 752
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 753 ENWYEGRIPGTSRQGIFPITYV---------------DVIKRPLVKNPVDYMDLPFSSSP 797
+W+ G + + G+FP YV + K+P + + ++ P
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYT---ATGP 1090
Query: 798 SRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRV---------------------T 836
+ A QL + E E +Q + ++R++
Sbjct: 1091 EQLTLAPGQLILIRKKNPGGWWEGE---LQARGKKRQIGWFPANYVKLLSPGTSKITPTE 1147
Query: 837 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 896
P +S + +Y Y QNDDEL G I++V+ K D W+ G Q G FP
Sbjct: 1148 PPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFP 1205
Query: 897 GNYVK 901
NYVK
Sbjct: 1206 SNYVK 1210
Score = 64.7 bits (156), Expect = 4e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 547 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 601
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 602 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 649
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 650 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 704
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 705 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 760
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 761 PGTSRQGIFPITYV 774
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 58.9 bits (141), Expect = 2e-08
Identities = 147/765 (19%), Positives = 281/765 (36%), Gaps = 122/765 (15%)
Query: 171 SFSPPPPLVPPA--PEDLRRVSEPDLTGAVSSTD------SSPLLNEVSSSLIGTDSQAF 222
S P PP++PP P RRV +SST P+L + L F
Sbjct: 291 SGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF 350
Query: 223 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSP 282
+ + + + LL+ R++Q+RL+ L ER+ E+ QE+
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERER-----QEQERKR 405
Query: 283 GKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSK--DWYKTMFKQIHKLNRDD 340
+EK+ + R + + ++ ++ R ER + +W R+
Sbjct: 406 QLELEKQL-EKQRELERQREEERRKEIERREAAKRELERQRQLEW-----------ERNR 453
Query: 341 DSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERND 400
+L + R ED + V ++K + + E + + L + + +++R +
Sbjct: 454 RQELLNQRNKEQED----IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE 509
Query: 401 WEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELE 460
E +K + R I E + + +++M + PE+ L ++ + L
Sbjct: 510 IESTNKSRELR--------IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLH 561
Query: 461 FGKPPPKKIWDYTPGDCSILPREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAP 520
K ++ +E + E+ ET + + + +
Sbjct: 562 RDSLVTLKR--------ALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLK----- 608
Query: 521 GDLTSLENERQIYKSVLEGGDIPLQG-----LSGLKRPSSSASTKDSESPRHFIPADYLE 575
+L + N++Q+ K + Q + L++ A + E + ++ E
Sbjct: 609 -ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQE 667
Query: 576 STEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQ----------FITN 625
+ R+ H++++ + + K +E+ A+ G + HQ + T
Sbjct: 668 DEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTA 727
Query: 626 ERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQ-IDQN---- 680
E+ G L T + ++ RA + F++++ E+ +Q GDIV + + +D++
Sbjct: 728 EK-GPL-----TISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGE 781
Query: 681 --WYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMS 738
W GE G+ G FP Y E +P E P K V + A A +T ++
Sbjct: 782 PGWLGGELKGKTGWFPANYAEKIPENEVPAPVK----PVTDSTSAPAPKLALRETPAPLA 837
Query: 739 FRKGERITLLRQVDENW--YEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSS 796
E T NW + P ++ + K D D +++
Sbjct: 838 VTSSEPST----TPNNWADFSSTWPTSTNE----------------KPETDNWD-AWAAQ 876
Query: 797 PSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYI 856
PS + ++ QL S T S S V Q ++ + QALY +
Sbjct: 877 PSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEK-----------VEGLQAQALYPWR 925
Query: 857 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
+ D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 926 AKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 51.2 bits (121), Expect = 4e-06
Identities = 54/196 (27%), Positives = 83/196 (42%), Gaps = 48/196 (24%)
Query: 713 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 766
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQG--QK 958
Query: 767 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSP-SRSATASPQLSHHSLRAGPDLTESEKSY 825
G FP +YV +I P+ K+ MD S SP S ASP A P ++ E
Sbjct: 959 GWFPKSYVKLISGPIRKSTS--MDSGSSESPASLKRVASPA-------AKPVVSGEE--- 1006
Query: 826 VQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 885
+ A+Y+Y +L + GD++ V +K D W+ GT
Sbjct: 1007 -----------------------FIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGT 1042
Query: 886 SRRTKQFGTFPGNYVK 901
+ G FP NYV+
Sbjct: 1043 V--GDKAGVFPSNYVR 1056
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 653 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 708
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 33.9 bits (76), Expect = 0.70
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 9/71 (12%)
Query: 840 SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------VDVMEKCDDGWFVGTSRRTKQF 892
+Q + + Y+ALY + ++ DE+ ++ GDI VD + + GW G + +
Sbjct: 736 AQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELK--GKT 793
Query: 893 GTFPGNYVKPL 903
G FP NY + +
Sbjct: 794 GWFPANYAEKI 804
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,321,622
Number of Sequences: 37866
Number of extensions: 2084333
Number of successful extensions: 13849
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 632
Number of HSP's that attempted gapping in prelim test: 10506
Number of HSP's gapped (non-prelim): 3067
length of query: 905
length of database: 18,247,518
effective HSP length: 111
effective length of query: 794
effective length of database: 14,044,392
effective search space: 11151247248
effective search space used: 11151247248
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.