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Search of human proteins with 7706318
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
(339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 684 0.0
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 150 2e-36
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 113 2e-25
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 100 3e-21
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 96 5e-20
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 96 5e-20
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 96 6e-20
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 94 2e-19
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 92 5e-19
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 90 3e-18
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 90 3e-18
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 83 3e-16
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 82 5e-16
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 81 1e-15
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 79 8e-15
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 79 8e-15
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 77 2e-14
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 77 2e-14
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 77 2e-14
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 77 2e-14
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 77 2e-14
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 76 4e-14
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 76 4e-14
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 75 8e-14
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 74 1e-13
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 74 2e-13
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 72 5e-13
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 72 5e-13
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 72 5e-13
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 72 7e-13
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 684 bits (1765), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS 60
MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS
Sbjct: 1 MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS 60
Query: 61 GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA 120
GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA
Sbjct: 61 GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA 120
Query: 121 ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER 180
ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER
Sbjct: 121 ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER 180
Query: 181 KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN 240
KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN
Sbjct: 181 KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN 240
Query: 241 IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY 300
IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY
Sbjct: 241 IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY 300
Query: 301 MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD 339
MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD
Sbjct: 301 MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD 339
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 150 bits (378), Expect = 2e-36
Identities = 89/205 (43%), Positives = 125/205 (60%), Gaps = 5/205 (2%)
Query: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLK---EKD 104
L + VV +TGA+SG+G+E A G LVL R LE + R + K K
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 105 ILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYL 164
LV DLTD+G+ AA +LQ FG +DILVNN G+S R MDT++DV ++++E NY
Sbjct: 110 YLVT-FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 165 GTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY 224
G V+LTK +LP MI+R+QG IV ++SI G +S+P Y ASKHA + FF+ LR E+ Y
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 225 PGIIVSNICPGPVQSNIVENSLAGE 249
I V+ I PG + +N+ N++ +
Sbjct: 229 E-IEVTVISPGYIHTNLSVNAITAD 252
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 113 bits (283), Expect = 2e-25
Identities = 77/232 (33%), Positives = 125/232 (53%), Gaps = 13/232 (5%)
Query: 10 LVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQ 69
+++ LLLL + L F+ + ++ LW++ + + VV +T A SG+G+E A
Sbjct: 6 MLMLPLLLLGISGLLFIYQE--VSRLWSKSA-------VQNKVVVITDAISGLGKECARV 56
Query: 70 LSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDI--LVLPLDLTDTGSHEAATKAVLQ 127
G LVL + LE + + + + LVL LDL+D K VL
Sbjct: 57 FHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVL-LDLSDISCVPDVAKEVLD 115
Query: 128 EFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVT 187
+G +DIL+NN + + SL++ +K+++ NY G ++LTK +LP+MI R+ G+IV
Sbjct: 116 CYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVL 175
Query: 188 VNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQS 239
VN+I G +P Y ASKHA GFF+ LR E+ Y +++S + P ++S
Sbjct: 176 VNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEY-DVVISTVSPTFIRS 226
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 99.8 bits (247), Expect = 3e-21
Identities = 68/199 (34%), Positives = 93/199 (46%), Gaps = 6/199 (3%)
Query: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107
+T +V +TGA GIG AY+ +KL LVL H LE +C G +
Sbjct: 34 VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLG----AKVHT 89
Query: 108 LPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTV 167
+D ++ ++ K V E G + ILVNN G+ S T K E+N L
Sbjct: 90 FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHF 149
Query: 168 SLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELAT--YP 225
TK LP M + G IVTV S G +SVP + YC+SK A GF L ELA
Sbjct: 150 WTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQIT 209
Query: 226 GIIVSNICPGPVQSNIVEN 244
G+ + +CP V + ++N
Sbjct: 210 GVKTTCLCPNFVNTGFIKN 228
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 95.9 bits (237), Expect = 5e-20
Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 5/178 (2%)
Query: 43 RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102
RPE L V VTGAS GIG E+AY L+K+G +V++AR L++V CLE G
Sbjct: 28 RPEM-LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASA 86
Query: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELN 162
I D+T A ++ G +D+L+ N + + RK +E+N
Sbjct: 87 HYIAGTMEDMTFAEQFVAQAGKLM---GGLDMLILNHITNTSLNLFHDDIHHVRKSMEVN 143
Query: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTE 220
+L V LT LP M+++ G IV V+S+ G ++ P+ Y ASK AL GFF+ +R E
Sbjct: 144 FLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKE 200
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 95.9 bits (237), Expect = 5e-20
Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 5/178 (2%)
Query: 43 RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102
RPE L V VTGAS GIG E+AY L+K+G +V++AR L++V CLE G
Sbjct: 28 RPEM-LQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASA 86
Query: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELN 162
I D+T A ++ G +D+L+ N + + RK +E+N
Sbjct: 87 HYIAGTMEDMTFAEQFVAQAGKLM---GGLDMLILNHITNTSLNLFHDDIHHVRKSMEVN 143
Query: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTE 220
+L V LT LP M+++ G IV V+S+ G ++ P+ Y ASK AL GFF+ +R E
Sbjct: 144 FLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKE 200
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 95.5 bits (236), Expect = 6e-20
Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 11/202 (5%)
Query: 53 VWVTGASSGIGEELAYQLS---KLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLP 109
V ++G SSGIG ELA QL+ K +V + R + + E ++ G + + V
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAA---GEALGQTLTVAQ 64
Query: 110 LDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSL 169
LD+ S E+ + + G +D+LVNN GM SL + + + N+ G V L
Sbjct: 65 LDVC---SDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 170 TKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIV 229
K VLP M R+QG IV ++S++G+ V + Y ASK AL GFF L +L + I +
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQF-NIFI 180
Query: 230 SNICPGPVQSNIVENSLAGEVT 251
S + PGPV + E L +V+
Sbjct: 181 SLVEPGPVVTEF-EGKLLAQVS 201
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/195 (32%), Positives = 93/195 (47%), Gaps = 6/195 (3%)
Query: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
+V +TGA GIG + Y+ +K LVL +E C + G ++ D
Sbjct: 38 IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV----D 93
Query: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
++ + V +E G + I+VNN G + + T + K E+N LG +TK
Sbjct: 94 CSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITK 153
Query: 172 CVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY--PGIIV 229
+LP M+ER G IVTV S+ G +P I YC+SK A GF GL +EL GI
Sbjct: 154 ALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKT 213
Query: 230 SNICPGPVQSNIVEN 244
S +CP V + +N
Sbjct: 214 SCLCPVFVNTGFTKN 228
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 92.4 bits (228), Expect = 5e-19
Identities = 73/264 (27%), Positives = 127/264 (48%), Gaps = 36/264 (13%)
Query: 53 VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDI-LVLPLD 111
V VTG SSGIG+ +A + K G + L AR +L + K+ +E ++ +K + L + +D
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE-IEMHSINDKQVVLCISVD 93
Query: 112 LT-DTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLT 170
++ D E K ++ G +D+LVN GM+ D + + +L+ +NYLG+V +
Sbjct: 94 VSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPS 153
Query: 171 KCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY------ 224
+ V+ M ER+ G+IV V+S G + + Y ASK A+RG L+ E+ Y
Sbjct: 154 RAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITV 213
Query: 225 --------PGIIVSN---------------IC-PGPVQSNIVENSLAGEVTKTIGNNGDQ 260
PG N +C P V IV++++ G ++G++G
Sbjct: 214 AYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDG-- 271
Query: 261 SHKMTTSRCVRLMLISMANDLKEV 284
+ ++ C + S+ L++V
Sbjct: 272 -YMLSALTCGMAPVTSITEGLQQV 294
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 90.1 bits (222), Expect = 3e-18
Identities = 60/181 (33%), Positives = 93/181 (51%), Gaps = 4/181 (2%)
Query: 53 VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDL 112
V +TGA++G+GEELAY ++LG LVL+A L++V C + G K + + D+
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPK---VFYIAADM 88
Query: 113 TDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKC 172
+ E+ + L + G +D LV N + S R L+++N++ V LT
Sbjct: 89 ASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
Query: 173 VLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232
LP + + K G +V V+S+LG + S Y A+K AL GFF LR EL + +
Sbjct: 149 ALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM 207
Query: 233 C 233
C
Sbjct: 208 C 208
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 90.1 bits (222), Expect = 3e-18
Identities = 60/181 (33%), Positives = 93/181 (51%), Gaps = 4/181 (2%)
Query: 53 VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDL 112
V +TGA++G+GEELAY ++LG LVL+A L++V C + G K + + D+
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPK---VFYIAADM 88
Query: 113 TDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKC 172
+ E+ + L + G +D LV N + S R L+++N++ V LT
Sbjct: 89 ASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148
Query: 173 VLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232
LP + + K G +V V+S+LG + S Y A+K AL GFF LR EL + +
Sbjct: 149 ALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITM 207
Query: 233 C 233
C
Sbjct: 208 C 208
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 11/186 (5%)
Query: 53 VWVTGASSGIGEELAYQLSKLGV-SLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
V +TG GIG +LA + ++ G +VL R L+ + G I
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC----- 95
Query: 112 LTDTGSHEAA---TKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVS 168
D G+ E KAV ++ G I ILVNN + MD+ D K +N LG
Sbjct: 96 --DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFW 153
Query: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228
TK LP M+E + G IV +NS+L + ++P +I YC SK + F L L PG+
Sbjct: 154 TTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVS 213
Query: 229 VSNICP 234
+ + P
Sbjct: 214 ATTVLP 219
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 82.4 bits (202), Expect = 5e-16
Identities = 61/195 (31%), Positives = 86/195 (44%), Gaps = 42/195 (21%)
Query: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
+V +TGA GIG + Y+ +K LVL ++ +VK+
Sbjct: 38 IVLITGAGHGIGRQTTYEFAKRQSILVL-----WDINKVKK------------------- 73
Query: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
E G + I+VNN G + + T + K E+N LG +TK
Sbjct: 74 ----------------EVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITK 117
Query: 172 CVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY--PGIIV 229
+LP M+ER G IVTV S+ G +P I YC+SK A GF GL +EL GI
Sbjct: 118 ALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKT 177
Query: 230 SNICPGPVQSNIVEN 244
S +CP V + +N
Sbjct: 178 SCLCPVFVNTGFTKN 192
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 81.3 bits (199), Expect = 1e-15
Identities = 63/202 (31%), Positives = 99/202 (49%), Gaps = 15/202 (7%)
Query: 52 VVWVTGASSGIGEELAYQLS-------KLGVSLVLSARRVHELERVKRRCLENGNLKEKD 104
VV +TG SSGIG LA +L+ K+ +L + E + G+L+
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLE--- 61
Query: 105 ILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYL 164
L LD+ D+ S AA + V + GR+D+LV N G+ D ++++N +
Sbjct: 62 --TLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVV 117
Query: 165 GTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY 224
GTV + + LP M R G+++ S+ G++ +P + YCASK AL G L L +
Sbjct: 118 GTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPF 177
Query: 225 PGIIVSNICPGPVQSNIVENSL 246
G+ +S I GPV + +E L
Sbjct: 178 -GVHLSLIECGPVHTAFMEKVL 198
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 78.6 bits (192), Expect = 8e-15
Identities = 60/185 (32%), Positives = 96/185 (51%), Gaps = 12/185 (6%)
Query: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTD 114
VTG++ GIG+ A +L+K G+ +VL +R +L++V E ++ + I V D
Sbjct: 55 VTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAV------D 108
Query: 115 TGSHEAATKAVLQEFG-RIDILVNNGGMS----QRSLCMDTSLDVYRKLIELNYLGTVSL 169
S + K G I ILVNN GMS + L + +V +K+I +N L +
Sbjct: 109 FASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKM 168
Query: 170 TKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIV 229
T+ VLP M+ER +G I+ ++S G++ VPL Y A+K + F L E + G+ V
Sbjct: 169 TQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS-KGVFV 227
Query: 230 SNICP 234
++ P
Sbjct: 228 QSVLP 232
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 78.6 bits (192), Expect = 8e-15
Identities = 79/253 (31%), Positives = 118/253 (46%), Gaps = 31/253 (12%)
Query: 7 LWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEEL 66
L LL+L LL + +R + + G T +L VV VTGA++GIG+E
Sbjct: 8 LLLLLLPFLLYMAAPQIRKMLSSGVCT----------STVQLPGKVVVVTGANTGIGKET 57
Query: 67 AYQLSKLGVSLVLSARRVHELERVKRRC-LENGNLKEKDILVLPLDLTDTGSHEAATKAV 125
A +L++ G + L+ R V + E V + GN + +LV LDL+DT S A K
Sbjct: 58 AKELAQRGARVYLACRDVEKGELVAKEIQTTTGN---QQVLVRKLDLSDTKSIRAFAKGF 114
Query: 126 LQEFGRIDILVNNGGMSQRSLC-MDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGK 184
L E + +L+NN G+ +C + D + I +N+LG LT +L + E +
Sbjct: 115 LAEEKHLHVLINNAGV---MMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSR 171
Query: 185 IVTVNSI---LGIIS---------VPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNI 232
IV V+S+ LG I + YC SK A F L L G+ ++
Sbjct: 172 IVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG-SGVTTYSV 230
Query: 233 CPGPVQSNIVENS 245
PG VQS +V +S
Sbjct: 231 HPGTVQSELVRHS 243
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)
Query: 35 LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94
LW +G+ ++TD +++TG SG G A K G ++ + +K
Sbjct: 15 LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 95 LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151
E + + LD+TD + + + V + G + L+NN G+ D +
Sbjct: 74 SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
Query: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211
L+ YR+ IE+N G +S+T +LP ++++ QG+++ V+S+ G +++ + GY SK+A+
Sbjct: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
Query: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243
GF + LR ++ + G+ VS I PG ++N+ +
Sbjct: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 77.4 bits (189), Expect = 2e-14
Identities = 62/214 (28%), Positives = 112/214 (52%), Gaps = 13/214 (6%)
Query: 25 FLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRV 84
+L A L L ++ R+ L D V++TG SG G LA QL G+ ++ +
Sbjct: 4 YLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTE 63
Query: 85 HELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGG-M 141
E+++ + + + + LD+T S AAT+ V + G + LVNN G +
Sbjct: 64 KGAEQLRGQTSDR-------LETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGIL 116
Query: 142 SQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSI 201
+ +LC + + ++++N +G + +T +LP ++ R +G+IV V+SILG ++ +
Sbjct: 117 TPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAFFVG- 174
Query: 202 GYCASKHALRGFFNGLRTELATYPGIIVSNICPG 235
GYC SK+ + F + LR E+ + G+ +S + PG
Sbjct: 175 GYCVSKYGVEAFSDILRREIQHF-GVKISIVEPG 207
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)
Query: 35 LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94
LW +G+ ++TD +++TG SG G A K G ++ + +K
Sbjct: 15 LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 95 LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151
E + + LD+TD + + + V + G + L+NN G+ D +
Sbjct: 74 SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
Query: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211
L+ YR+ IE+N G +S+T +LP ++++ QG+++ V+S+ G +++ + GY SK+A+
Sbjct: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
Query: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243
GF + LR ++ + G+ VS I PG ++N+ +
Sbjct: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)
Query: 35 LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94
LW +G+ ++TD +++TG SG G A K G ++ + +K
Sbjct: 15 LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 95 LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151
E + + LD+TD + + + V + G + L+NN G+ D +
Sbjct: 74 SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
Query: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211
L+ YR+ IE+N G +S+T +LP ++++ QG+++ V+S+ G +++ + GY SK+A+
Sbjct: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
Query: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243
GF + LR ++ + G+ VS I PG ++N+ +
Sbjct: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)
Query: 35 LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94
LW +G+ ++TD +++TG SG G A K G ++ + +K
Sbjct: 15 LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
Query: 95 LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151
E + + LD+TD + + + V + G + L+NN G+ D +
Sbjct: 74 SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
Query: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211
L+ YR+ IE+N G +S+T +LP ++++ QG+++ V+S+ G +++ + GY SK+A+
Sbjct: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
Query: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243
GF + LR ++ + G+ VS I PG ++N+ +
Sbjct: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 76.3 bits (186), Expect = 4e-14
Identities = 58/199 (29%), Positives = 97/199 (48%), Gaps = 15/199 (7%)
Query: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
VV VTG GIG + G +V+ + + R LE + + + D
Sbjct: 11 VVVVTGGGRGIGAGIVRAFVNSGARVVICDK-----DESGGRALEQ---ELPGAVFILCD 62
Query: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMS---QRSLCMDTSLDVYRKLIELNYLGTVS 168
+T + ++ FGR+D +VNN G QR +TS +R+L+ELN LGT +
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRP--EETSAQGFRQLLELNLLGTYT 120
Query: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228
LTK LP+ + + QG ++ ++S++G I ++ Y A+K A+ L + + Y G+
Sbjct: 121 LTKLALPY-LRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY-GVR 178
Query: 229 VSNICPGPVQSNIVENSLA 247
V+ I PG + + + E A
Sbjct: 179 VNCISPGNIWTPLWEELAA 197
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 76.3 bits (186), Expect = 4e-14
Identities = 65/221 (29%), Positives = 96/221 (43%), Gaps = 23/221 (10%)
Query: 37 AEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVL-------------SARR 83
A W R E + V +TGA SG+G A + ++ LVL R
Sbjct: 23 ARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRH 82
Query: 84 VH-ELERVKRRCLENGNLKEKDILVLPLDL----TDTGSHE---AATKAVLQEFGRIDIL 135
++ +LE L+ GN +E+ + L + D G E + V +E G + +L
Sbjct: 83 IYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVL 142
Query: 136 VNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGII 195
VNN G+ ++ ++ + + +N TK LP M+E G IVTV S LG+
Sbjct: 143 VNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLF 202
Query: 196 SVPLSIGYCASKHALRGFFNGLRTEL--ATYPGIIVSNICP 234
S YCASK + GF L EL A GI + +CP
Sbjct: 203 STAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCP 243
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 75.1 bits (183), Expect = 8e-14
Identities = 56/208 (26%), Positives = 90/208 (43%), Gaps = 5/208 (2%)
Query: 43 RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKE 102
+P + +V +TGA SG+G LA Q ++LG LVL E + E G +
Sbjct: 33 KPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATR- 91
Query: 103 KDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELN 162
+ D + V +E G + IL+NN G+ +D ++ K ++N
Sbjct: 92 --VHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVN 149
Query: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNG--LRTE 220
+ + K LP MI G +V ++S G+ V YCASK A GF + T
Sbjct: 150 FKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETF 209
Query: 221 LATYPGIIVSNICPGPVQSNIVENSLAG 248
+ GI + +CP +++ + E G
Sbjct: 210 VQKQKGIKTTIVCPFFIKTGMFEGCTTG 237
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 74.3 bits (181), Expect = 1e-13
Identities = 60/193 (31%), Positives = 106/193 (54%), Gaps = 17/193 (8%)
Query: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107
L D V++TG SG G+ LA QL G+ ++ + E+++ + + +
Sbjct: 27 LRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDR-------LET 79
Query: 108 LPLDLTDTGSHEAA---TKAVLQEFGRIDILVNNGGMSQRSLCMD--TSLDVYRKLIELN 162
+ LD+T T S AA K +++ G + LVNN G+S + + T D + ++++N
Sbjct: 80 VTLDVTKTESVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQD-FVTILDVN 137
Query: 163 YLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELA 222
LG + +T +LP ++ R +G++V V+S++G +S+ GYC SK+ + F + LR EL
Sbjct: 138 LLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRREL- 194
Query: 223 TYPGIIVSNICPG 235
+Y G+ V+ I PG
Sbjct: 195 SYFGVKVAMIEPG 207
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 73.9 bits (180), Expect = 2e-13
Identities = 71/256 (27%), Positives = 120/256 (46%), Gaps = 17/256 (6%)
Query: 4 ELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVW--VTGASSG 61
++L +L LL+ L L + +R + L + W+ P+ L M W +TGA G
Sbjct: 3 DVLEQFFILTGLLVCLACLAKCVRFSRCVLLNY--WKVL-PKSFLRSMGQWAVITGAGDG 59
Query: 62 IGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLT--DTGSHE 119
IG+ +++L+K G+++VL +R + +LE + E + + ++ D T D H
Sbjct: 60 IGKAYSFELAKRGLNVVLISRTLEKLEAI---ATEIERTTGRSVKIIQADFTKDDIYEHI 116
Query: 120 AATKAVLQEFGRIDILVNNGGMSQRSLCMD--TSLDVYRKLIELNYLGTVSLTKCVLPHM 177
A L+ I ILVNN GM L + D + LI N V +T+ +L HM
Sbjct: 117 KEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHM 172
Query: 178 IERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPV 237
R++G I+ ++S + + PL Y ASK + F L+ E +I+ + P V
Sbjct: 173 ESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKA-KEVIIQVLTPYAV 231
Query: 238 QSNIVENSLAGEVTKT 253
+ + + +TKT
Sbjct: 232 STAMTKYLNTNVITKT 247
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 72.4 bits (176), Expect = 5e-13
Identities = 57/198 (28%), Positives = 93/198 (46%), Gaps = 16/198 (8%)
Query: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
V VTGA+ GIG A L G + L + + K E + + L + D
Sbjct: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQ--FEPQKTLFIQCD 64
Query: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
+ D + V+ FGR+DILVNN G++ + K +++N + +S T
Sbjct: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEK--------NWEKTLQINLVSVISGTY 116
Query: 172 CVLPHMIERKQGK---IVTVNSILGIISVPLSIGYCASKHALRGFFN--GLRTELATYPG 226
L +M ++ G+ I+ ++S+ G++ V YCASKH + GF L L G
Sbjct: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN-SG 175
Query: 227 IIVSNICPGPVQSNIVEN 244
+ ++ ICPG V + I+E+
Sbjct: 176 VRLNAICPGFVNTAILES 193
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 72.4 bits (176), Expect = 5e-13
Identities = 85/336 (25%), Positives = 150/336 (44%), Gaps = 51/336 (15%)
Query: 3 WELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGI 62
W ++ L LCA+ LL++ L L + + + V VTG G+
Sbjct: 35 WSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGL 94
Query: 63 GEELAYQLSKLGVSLVLSARRVHE--LERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA 120
G L L +LG ++ + E ++R C ++ + DI P+ + D S A
Sbjct: 95 GHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDI-TKPVQIKDAYSKVA 153
Query: 121 ATKAVLQEFGRIDILVNNGGM----SQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPH 176
A +LQ+ G + ++NN G+ + L + T Y++ + +N+ GTV +TK LP
Sbjct: 154 A---MLQDRG-LWAVINNAGVLGFPTDGELLLMTD---YKQCMAVNFFGTVEVTKTFLP- 205
Query: 177 MIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGP 236
++ + +G++V V+S+ G + Y +SK A+ F + +R EL+ + GI V++I PG
Sbjct: 206 LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKW-GIKVASIQPGG 264
Query: 237 VQSNIVENS-------------LAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMAN---- 279
+NI S L EV + G + + R L++ S+A+
Sbjct: 265 FLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQD-----YILAQRNFLLLINSLASKDFS 319
Query: 280 ----DLKEVWISEQPFLLVT-----YLW----QYMP 302
D++ +++ PF T YLW Y+P
Sbjct: 320 PVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLP 355
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 72.4 bits (176), Expect = 5e-13
Identities = 63/210 (30%), Positives = 109/210 (51%), Gaps = 21/210 (10%)
Query: 34 LLWAE-WQGR-RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVK 91
LLWA W R R ++ V++TG SG G LA QL + G ++ S E ++
Sbjct: 10 LLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQ 69
Query: 92 RRCLENGNLKEKDILVLPLDLTDTGSHEAATKAV---LQEFGRIDILVNNGGMSQRSLCM 148
R + + LD+TD S + A K V ++E G LVNN G++ +
Sbjct: 70 R-------VASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFG-LVNNAGVA--GIIG 119
Query: 149 DT---SLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCA 205
T + D +++++ +N +G + +T +LP ++++ +G+++ + S+LG ++ GYC
Sbjct: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLGRLAAN-GGGYCV 177
Query: 206 SKHALRGFFNGLRTELATYPGIIVSNICPG 235
SK L F + LR ++A + GI VS + PG
Sbjct: 178 SKFGLEAFSDSLRRDVAHF-GIRVSIVEPG 206
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 72.0 bits (175), Expect = 7e-13
Identities = 56/195 (28%), Positives = 92/195 (47%), Gaps = 7/195 (3%)
Query: 50 DMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLP 109
D + VTGAS GIG +A L + G+ +V AR V +E + C G ++
Sbjct: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAG--YPGTLIPYR 68
Query: 110 LDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSL 169
DL++ + A+ + +DI +NN G+++ + S ++ + +N L
Sbjct: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSIC 128
Query: 170 TKCVLPHMIERK--QGKIVTVNSILGIISVPLSIG--YCASKHALRGFFNGLRTEL-ATY 224
T+ M ER G I+ +NS+ G +PLS+ Y A+K+A+ GLR EL
Sbjct: 129 TREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ 188
Query: 225 PGIIVSNICPGPVQS 239
I + I PG V++
Sbjct: 189 THIRATCISPGVVET 203
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,256,634
Number of Sequences: 37866
Number of extensions: 502151
Number of successful extensions: 1315
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1184
Number of HSP's gapped (non-prelim): 81
length of query: 339
length of database: 18,247,518
effective HSP length: 103
effective length of query: 236
effective length of database: 14,347,320
effective search space: 3385967520
effective search space used: 3385967520
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.