Guide to the Human Genome
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Search of human proteins with 7706254

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
         (529 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]            1032   0.0  
gi|32483374 nucleolar protein 5A [Homo sapiens]                       345   6e-95
gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens]     129   5e-30
gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens]           77   3e-14
gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens]           77   3e-14
gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo sap...    77   3e-14
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    53   6e-07
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ...    53   8e-07
gi|221219020 NYD-SP11 protein [Homo sapiens]                           52   1e-06
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          51   3e-06
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]             50   4e-06
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    49   1e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    49   1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     48   2e-05
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            47   6e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       46   7e-05
gi|239750213 PREDICTED: hypothetical protein [Homo sapiens]            46   1e-04
gi|11225260 DNA topoisomerase I [Homo sapiens]                         45   1e-04
gi|46276863 parathymosin [Homo sapiens]                                45   1e-04
gi|104526627 triadin [Homo sapiens]                                    45   1e-04
gi|4503337 dyskerin isoform 1 [Homo sapiens]                           45   2e-04
gi|215599015 dyskerin isoform 2 [Homo sapiens]                         45   2e-04
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            45   2e-04
gi|4506751 restin isoform a [Homo sapiens]                             45   2e-04
gi|87299628 biorientation of chromosomes in cell division 1-like...    44   3e-04
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           44   4e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    44   4e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    44   4e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    44   4e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    44   4e-04

>gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
          Length = 529

 Score = 1032 bits (2668), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60
           MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF
Sbjct: 1   MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60

Query: 61  TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120
           TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR
Sbjct: 61  TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120

Query: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180
           SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI
Sbjct: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180

Query: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240
           MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI
Sbjct: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240

Query: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300
           SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA
Sbjct: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300

Query: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360
           HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR
Sbjct: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360

Query: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420
           MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE
Sbjct: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420

Query: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480
           HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE
Sbjct: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480

Query: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED
Sbjct: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529


>gi|32483374 nucleolar protein 5A [Homo sapiens]
          Length = 594

 Score =  345 bits (885), Expect = 6e-95
 Identities = 213/550 (38%), Positives = 322/550 (58%), Gaps = 32/550 (5%)

Query: 3   VLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPE----KANKIVKLKHFEKFQDTAEALA 58
           VLFE +VGYA+  +   K+++E+  L  + E       K + IV+L  F  F  +  AL 
Sbjct: 6   VLFEHAVGYALLAL---KEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALE 62

Query: 59  AFTALMEGKINKQLKKVLKKIV--KEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELM 116
              A+ EG +++ L+ +L+  +  K+    L V D K+G  I+E+L  +C    V+ E++
Sbjct: 63  NANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEIL 122

Query: 117 RGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKEL 176
           RG+R     L+ G+         LGL HS SR ++KF+ ++VD MI+Q+ISLLD LDK++
Sbjct: 123 RGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDI 182

Query: 177 NNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVE-AEVK 235
           N + MR REWYG+HFPEL KII+DN TYC+  Q +G+R+     KL +L    ++ A+ K
Sbjct: 183 NTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAK 242

Query: 236 A---AAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGE 292
           A   A+  SMG ++S  D+ NI    ++V+ +SEYR  L+ YL+++M  +AP+++ ++GE
Sbjct: 243 AILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGE 302

Query: 293 LVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSP 352
            VGARLIAHAGSL NLAK+ ASTVQILGAEKALFRALK+R +TPKYGLI+H++ +G+ + 
Sbjct: 303 AVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAA 362

Query: 353 KHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLR-------------TLE 399
           K+KG+ISR LA K  +A R D F E  +S  G + R ++E RL               ++
Sbjct: 363 KNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMK 422

Query: 400 DRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459
           +  ++      +   K EK E K   K  +    + L   S +      ++ +E++EK  
Sbjct: 423 EAMVQAEEAAAEITRKLEKQEKKRLKK--EKKRLAALALASSENSSSTPEECEEMSEKPK 480

Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK 519
           KK   K K +E  +E   E+   S  K KK  KK   KEE +S +   T+ + + P++KK
Sbjct: 481 KKK--KQKPQEVPQENGMEDPSISFSKPKK--KKSFSKEELMSSDLEETAGSTSIPKRKK 536

Query: 520 KKKKKRENED 529
              K+    D
Sbjct: 537 STPKEETVND 546


>gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens]
          Length = 499

 Score =  129 bits (325), Expect = 5e-30
 Identities = 70/236 (29%), Positives = 129/236 (54%), Gaps = 2/236 (0%)

Query: 161 MIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDR--KNYA 218
           +IV A +L  +++ ELN      R+ Y   FPEL  ++ + L Y + ++++G+   K   
Sbjct: 92  VIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKN 151

Query: 219 SAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNR 278
           +  L ++L       V   A  + G ++SEE++  +   C   +E++  + ++YEY+++R
Sbjct: 152 NENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESR 211

Query: 279 MMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKY 338
           M  IAPN+++++G    A+++  AG L NL+K  A  + +LGA++       S    P  
Sbjct: 212 MSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHT 271

Query: 339 GLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEAR 394
           G IYH+ +V    P  + K +R++AAK  LA R D+F E +   +G E + ++E +
Sbjct: 272 GYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERK 327


>gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens]
          Length = 278

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)

Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
           ++ +TPKYGL++H++  GQ + ++KG+IS+ LA K  +A + D F E   S  G + + +
Sbjct: 2   TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61

Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
           +E RL   E         TG+ L+K         +KT     + T     +K + ++  +
Sbjct: 62  VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107

Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
           E   T  K KK K K K +E  +E   ++   S  K  KR  K   KE+ +S     T+ 
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164

Query: 511 AIASPEKKKKKKKKRENED 529
           +I+ P +K    K+    D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183


>gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens]
          Length = 278

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)

Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
           ++ +TPKYGL++H++  GQ + ++KG+IS+ LA K  +A + D F E   S  G + + +
Sbjct: 2   TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61

Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
           +E RL   E         TG+ L+K         +KT     + T     +K + ++  +
Sbjct: 62  VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107

Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
           E   T  K KK K K K +E  +E   ++   S  K  KR  K   KE+ +S     T+ 
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164

Query: 511 AIASPEKKKKKKKKRENED 529
           +I+ P +K    K+    D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183


>gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo
           sapiens]
          Length = 278

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)

Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
           ++ +TPKYGL++H++  GQ + ++KG+IS+ LA K  +A + D F E   S  G + + +
Sbjct: 2   TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61

Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
           +E RL   E         TG+ L+K         +KT     + T     +K + ++  +
Sbjct: 62  VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107

Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
           E   T  K KK K K K +E  +E   ++   S  K  KR  K   KE+ +S     T+ 
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164

Query: 511 AIASPEKKKKKKKKRENED 529
           +I+ P +K    K+    D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 31/97 (31%), Positives = 52/97 (53%)

Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
           + T  T   + + E+  K  E  ++K K+ + K K +E E+ K  EEEE   K+K+K+ K
Sbjct: 11  EETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKK 70

Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           ++  +EE   EEE           +++KKKKKR  ++
Sbjct: 71  EEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 15/104 (14%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEE-----------EEEKVAEEEETSVKKKKK 489
           KK++ E+ ++ +E  E++ K+ K K K +E+           E EK  E+EE   K+K+K
Sbjct: 6   KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65

Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPE----KKKKKKKKRENED 529
           R KKK  +E    EEE          E    +KKKKK++R+ E+
Sbjct: 66  RKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 19/127 (14%)

Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---------EKKAKK 461
           K   +TE+ E   E +  +           +KRK ++  K+ + T         EKK K+
Sbjct: 5   KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64

Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
            + K K EEE EE+  EEEE   +++K+ G+++  K++   +EE          E++KKK
Sbjct: 65  KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEE----------EEEKKK 114

Query: 522 KKKRENE 528
           K++R+ +
Sbjct: 115 KRRRKTK 121



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 28/72 (38%), Positives = 41/72 (56%)

Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
           K KK K K   E EE E+  EEEE   K+K+KR +K+  KE+    +E          EK
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60

Query: 518 KKKKKKKRENED 529
           K+K+K+K++ E+
Sbjct: 61  KRKRKRKKKKEE 72



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 34/92 (36%), Positives = 51/92 (55%), Gaps = 14/92 (15%)

Query: 441 KKRKIEQVDKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHI 496
           KK+K ++ +K  E  E+ K +K K K K EEEE E+  EEEE   ++++K   R +KK  
Sbjct: 42  KKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101

Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
           K     EEE          EKKKK+++K + +
Sbjct: 102 KRRRKEEEE----------EKKKKRRRKTKKK 123



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 26/74 (35%), Positives = 42/74 (56%)

Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515
           +KK KK K   + EE EE +  EE+E   K+K+K  +K+  K++   E E          
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60

Query: 516 EKKKKKKKKRENED 529
           ++K+K+KKK+E E+
Sbjct: 61  KRKRKRKKKKEEEE 74



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 10/119 (8%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
           + + + E    T E     +  G  K   K ++ E + + KT +           KKRK 
Sbjct: 5   KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEE----------KVAEEEETSVKKKKKRGKKK 494
           ++  K++E   ++ ++ + + K EEE+EE          +  EEEE   KK++++ KKK
Sbjct: 65  KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123


>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
           sapiens]
          Length = 956

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 29/87 (33%), Positives = 46/87 (52%)

Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
           K + E+ +KE    E K  K + K K EEE+E K  E  E   K +K++ +K+ +KEE  
Sbjct: 349 KLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERR 408

Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528
            E +      +    KK+++K+ RE E
Sbjct: 409 KERQEALEAKLEEKRKKEEEKRLREEE 435



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 6/93 (6%)

Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
           GK L    + E K ++K              KK++ E+  KE E  EK+ K  K K + +
Sbjct: 345 GKQLKLRAEREEKEKLKE---EAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQ 401

Query: 470 EEEEEKVAEEE---ETSVKKKKKRGKKKHIKEE 499
             +EE+  E +   E  +++K+K+ ++K ++EE
Sbjct: 402 RLKEERRKERQEALEAKLEEKRKKEEEKRLREE 434



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 28/124 (22%), Positives = 63/124 (50%), Gaps = 15/124 (12%)

Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
           +L+ R    E   +++ +   K  AK +K E K E+K  +           +KR+ ++ +
Sbjct: 347 QLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEK-ELKEKERR---------EKREKDEKE 396

Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK-----EEPLSEE 504
           K ++   K+ ++ + +  +E + EEK  +EEE  +++++KR K +  +     ++P + +
Sbjct: 397 KAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQ 456

Query: 505 EPCT 508
            P T
Sbjct: 457 APKT 460


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 29/191 (15%)

Query: 357  KISRMLAAKTVLAIRYDAFGEDSSSAMGVENRA-----KLEARLRTLEDRGIRKISGTGK 411
            K  +M   ++ LA ++     D     G+E        K   R R    RG +       
Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215

Query: 412  ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI-----EQVDKEDEITEKKAKKAKIKV 466
             + + E  EH SE        +S L    K+  +     E+ ++E+E  E++ ++ + + 
Sbjct: 2216 QVDEVESEEHFSEEM------ESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269

Query: 467  KVEEEEEEKVAEEEETSVKKKKKRGKKKHI---------KEEPLSEEEPCTSTAIASPEK 517
            K EEE EEK  E+EE   KKKKK  KK+ +         KEE +SEEE    T   S E+
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE----TESLSDEE 2325

Query: 518  KKKKKKKRENE 528
            ++++    E E
Sbjct: 2326 EEEESCSLEEE 2336



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/149 (22%), Positives = 76/149 (51%), Gaps = 8/149 (5%)

Query: 379  SSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPT 438
            SS    VE+       + +L D   ++ S + +   + E+ E + E +  +   +     
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273

Query: 439  CSKKRKIEQVDKEDEITEKKAKKAKIKVKVE--EEEEEKVAEEEETSVKKKKKRGKKKHI 496
              +++++E+ ++E +  +K+ KK +++ K E  EE+EE ++EEE  S+  +++  +   +
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL 2333

Query: 497  KEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
            +EE   E+E      I   EK+ K +++R
Sbjct: 2334 EEEVDREKE------ILKKEKQFKLQEQR 2356



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/92 (28%), Positives = 51/92 (55%), Gaps = 15/92 (16%)

Query: 444  KIEQVDKEDEITEK------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
            ++++V+ E+  +E+      + +K +     EEEE E+  E EE  V+++++  K++   
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275

Query: 498  EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
            EE   E+E          E+KKKKKK+++ E+
Sbjct: 2276 EEKQVEKEE---------EEKKKKKKEKKKEE 2298



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 16/90 (17%)

Query: 450  KEDEITEKKAKKAKIKVKVEE-------------EEEEKVAEEEETSVKKKKKRGKKKHI 496
            KE+E+ +++ K  + K K+ E             EEE K+A+EEE  +++K+K  +    
Sbjct: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH--- 1787

Query: 497  KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
            KE+   EEE          EKK K  +KRE
Sbjct: 1788 KEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 24/141 (17%)

Query: 386  ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
            E   + E  +R  E+    +  G  K + K E+ + K +                K++K 
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK----------------KEKKK 2296

Query: 446  EQVDKEDEITEKK----AKKAKIKVKVEEEEEEKVAEEEETS----VKKKKKRGKKKHIK 497
            E+V +++E+ E+K    +++    +  EEEEEE  + EEE      + KK+K+ K +  +
Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356

Query: 498  EEPLSEEEPCTSTAIASPEKK 518
             + L   E   S     P  K
Sbjct: 2357 RKSLRGRERVLSILRGVPHGK 2377



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 22/70 (31%), Positives = 42/70 (60%), Gaps = 4/70 (5%)

Query: 440  SKKRKIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETS-VKKKKKRGKKKHI 496
            S K K +Q   E+E+T  E+ +++ + K +   EE+  + EE + + + +K+ R +KK  
Sbjct: 1530 SSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589

Query: 497  KEE-PLSEEE 505
            +EE  L++EE
Sbjct: 1590 QEERKLAQEE 1599



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 4/122 (3%)

Query: 382  AMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
            A   + RA+ E +L   E+    K++   + LA+ E+   ++ VK      +        
Sbjct: 1582 ARAEKKRAQEERKLAQEEE----KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637

Query: 442  KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
             +K E + +  E   ++A+K   K K   ++ EKVA EEE   KK  K  + K+I  + +
Sbjct: 1638 AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKV 1697

Query: 502  SE 503
             E
Sbjct: 1698 EE 1699



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 29/118 (24%), Positives = 58/118 (49%), Gaps = 29/118 (24%)

Query: 441  KKRKI-----EQVDKEDEITEKKAKKAK--IKVKVEEEEEEKVAEEE-------ETSVKK 486
            K+RK+       ++KE+++TE+++K A+   +V +++EEE  + EEE           +K
Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201

Query: 487  KKKRGKK---------------KHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
            + KRG K               +H  EE  S  +        S E++++++++ E E+
Sbjct: 2202 EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREE 2259



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 25/138 (18%)

Query: 414  AKTEKYEHKSEVKTYDPSG----DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
            +K ++Y+ + EV   +       +       ++R I++  K   I  K+A+  K + + E
Sbjct: 1533 SKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE 1592

Query: 470  E---EEEEKVAEEEETSVKKKKKRGK-----------------KKHIKEEPLSEE-EPCT 508
                +EEEK+A+EE    ++++K  +                 K   KEE L++  E  +
Sbjct: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLS 1652

Query: 509  STAIASPEKKKKKKKKRE 526
              A    +K+KK  KK E
Sbjct: 1653 QEAEKLAQKRKKLAKKWE 1670



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 6/129 (4%)

Query: 401  RGIRKISGTGKALAKTE----KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITE 456
            RG++K          TE    + E  +E    +    S     S    + ++ K+ +  E
Sbjct: 1098 RGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQE 1157

Query: 457  KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPE 516
            K   K  I + ++  ++ +   +++ + +K KK+ KKK  + + ++EE   T   +  P 
Sbjct: 1158 KDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEE--TTPPVMEQPV 1215

Query: 517  KKKKKKKKR 525
             KK K + R
Sbjct: 1216 TKKVKIQGR 1224



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 16/95 (16%)

Query: 442  KRKIEQVDKEDEITEKKAKKAKIKVK------VEEEEEEKVAEEEETSVKKKKK--RGKK 493
            +RK   +  ++ +T  K +  ++K K      +  + EEK+ +E+ET +KKK+K    +K
Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914

Query: 494  KHI--------KEEPLSEEEPCTSTAIASPEKKKK 520
            K +        K+E L++E+   +   A  + KK+
Sbjct: 1915 KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 24/109 (22%), Positives = 49/109 (44%), Gaps = 11/109 (10%)

Query: 421  HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKV 476
            H+   +              ++ K+ Q +++    E+K  +A +K+  ++ E    E K 
Sbjct: 1578 HRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637

Query: 477  AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS---TAIASPEKKKKKK 522
            A++EET      +RG+K   + E L+++    +     +A  E+K  KK
Sbjct: 1638 AQKEETLA----QRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 47/204 (23%), Positives = 88/204 (43%), Gaps = 7/204 (3%)

Query: 330 KSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKT-----VLAIRYDAFGEDSSSAMG 384
           +S+ +TP+   + H     +   K K  + +    KT     V      +  E S     
Sbjct: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAE 619

Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444
           V  +   + + +  +++ ++K +       K EK + K EV   +           KK +
Sbjct: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679

Query: 445 IE-QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE 503
           ++ +V KE +  EKK  K ++K +   +E +K  ++EE    KK+++  KK IK+ P   
Sbjct: 680 VKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDA 739

Query: 504 EEPCTSTAIA-SPEKKKKKKKKRE 526
           ++  T  + A  P   K K  K+E
Sbjct: 740 KKSSTPLSEAKKPAALKPKVPKKE 763



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%)

Query: 438 TCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
           T  K+ K++  DK++E  + K + AK + K   ++EEK  +EE   VKK+ K+  KK  K
Sbjct: 637 TVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE---VKKEVKKEIKKEEK 693

Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           +EP  E +  T       E KK++KK+ + E+
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 39/142 (27%), Positives = 70/142 (49%), Gaps = 20/142 (14%)

Query: 405 KISGTGKALAKTEK---YEHKSEVKTYD-PSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460
           K+    K + K +K    E K  V   + PS +   P  ++  + +  D + +  ++K  
Sbjct: 579 KVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV 638

Query: 461 KAKIKVKVEEEEEEK-------VAEEEETSVKKKKKRGK-------KKHIKEEPLSEEEP 506
           K + KVK E+++EEK         +E++T +KK++K  K       KK IK+E   ++EP
Sbjct: 639 KKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE--EKKEP 696

Query: 507 CTSTAIASPEKKKKKKKKRENE 528
                  +P K+ KK+ K+E +
Sbjct: 697 KKEVKKETPPKEVKKEVKKEEK 718



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 14/109 (12%)

Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
           K +K E K EVK              K+ K E+  +  +  +K+    ++K +V++EE++
Sbjct: 674 KPKKEEVKKEVK--------------KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKK 719

Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523
           +V +EE+   K+ KK  K       PLSE +   +     P+K++  KK
Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 22/112 (19%)

Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK--------- 461
           K + K EK E K EVK   P  +       KK + ++V KE++  +K+ KK         
Sbjct: 686 KEIKKEEKKEPKKEVKKETPPKEVKKEV--KKEEKKEVKKEEKEPKKEIKKLPKDAKKSS 743

Query: 462 ---------AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504
                    A +K KV ++EE    +++  +  K K++GK K IK+E  + E
Sbjct: 744 TPLSEAKKPAALKPKVPKKEES--VKKDSVAAGKPKEKGKIKVIKKEGKAAE 793



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 3/82 (3%)

Query: 445  IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS-- 502
            +  VD E    E+   KA  K   E+ + +K   + ++S   KK  GK K +   P    
Sbjct: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAG 2276

Query: 503  -EEEPCTSTAIASPEKKKKKKK 523
             +E     + +ASP+KK+  +K
Sbjct: 2277 LKESSDKVSRVASPKKKESVEK 2298


>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
          Length = 1316

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 10/92 (10%)

Query: 440  SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
            S+KR+ + V+  D   EKKA++++ K  +EE + +K  +       KKKK+ K KH   +
Sbjct: 1159 SRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKS------KKKKKSKDKHRDRD 1212

Query: 500  PLSEEEPCTSTAIASPE----KKKKKKKKREN 527
               +++   S A +  +    KKKKKKKKR +
Sbjct: 1213 SRHQQDSDLSAACSDADLHRHKKKKKKKKRHS 1244



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 7/52 (13%)

Query: 478  EEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
            E  ++ V+KK +R ++K   EEP +++           +KKKK K K  + D
Sbjct: 1168 ENSDSHVEKKARRSEQKDPLEEPKAKKHK-------KSKKKKKSKDKHRDRD 1212


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 50/192 (26%), Positives = 90/192 (46%), Gaps = 24/192 (12%)

Query: 349 QTSPKHKGK------ISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLE-DR 401
           +T  KHK K      IS+ L  K+     Y+   + S  A+ +EN    E +L+ L+ DR
Sbjct: 633 KTKHKHKNKEKGQCSISQELKLKS-FTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDR 691

Query: 402 G-IRKISGTGKALAKTEKY---EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457
              +K     K   + +++   + KS  +  D + D +     +K +  + +KE  + EK
Sbjct: 692 DHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEK 751

Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
             K+ K+++  EE +++        S  +  K  KK  +KE+ +S+E+      I   +K
Sbjct: 752 SPKEEKLRLYKEERKKK--------SKDRPSKLEKKNDLKEDKISKEKE----KIFKEDK 799

Query: 518 KKKKKKKRENED 529
           +K KK+K   ED
Sbjct: 800 EKLKKEKVYRED 811



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 12/94 (12%)

Query: 411  KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK-------KAKKAK 463
            K   K E+Y+ KS  K  D S  S L  C K ++ ++  KE + T++       K K+ K
Sbjct: 1020 KEKTKPERYKEKSSDK--DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK 1077

Query: 464  IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKK 494
              +   +E++EK       E+ S KK  K+GK+K
Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK 1111



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 11/113 (9%)

Query: 414  AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
            AK EK E K + + Y   G         ++   Q +K+    +       +K  +E+E +
Sbjct: 1366 AKKEKAEKKEKGEDYKEGGS--------RKDSGQYEKDFLEADAYGVSYNMKADIEDELD 1417

Query: 474  EKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
            + +   E  S +KK K   ++   ++   E +P  S+AI   ++KKK++K RE
Sbjct: 1418 KTI---ELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHRE 1467



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)

Query: 449  DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCT 508
            D++D  +    +  K K K+ E+ E+K A E++   K K+K   K+H KE   S      
Sbjct: 1219 DRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEK-SDKEHSKERKSSRSADAE 1277

Query: 509  STAIASPEKKKKKKKKRENED 529
             + +   E++   + + ++ D
Sbjct: 1278 KSLLEKLEEEALHEYREDSND 1298



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 4/82 (4%)

Query: 449  DKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHIKEEPLSEE 504
            DK++++ EK K KK K   +  ++ +++ + +     K K+K   + +KKH  E+    +
Sbjct: 1196 DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK 1255

Query: 505  EPCTSTAIASPEKKKKKKKKRE 526
                S    S E+K  +    E
Sbjct: 1256 HKEKSDKEHSKERKSSRSADAE 1277



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 32/142 (22%)

Query: 416  TEKYEHKSEVKTYDPSGDST----LPTCSKKRKI----------EQVDKEDEITEKKAKK 461
            TEKY+ + +  + D + D      LP  ++K+            E+ DKE     K ++ 
Sbjct: 1214 TEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRS 1273

Query: 462  AKI-KVKVEEEEEEKVAEEEETSVKKKKK--------RGKKKHIK-------EEPLSEEE 505
            A   K  +E+ EEE + E  E S  K  +        RG++  +         EP  +++
Sbjct: 1274 ADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDK 1333

Query: 506  PCTSTAIASPEKKKKKKKKREN 527
            P  S  +  PEK K+K++ R +
Sbjct: 1334 PRESACL--PEKLKEKERHRHS 1353


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 40/144 (27%), Positives = 73/144 (50%), Gaps = 7/144 (4%)

Query: 384 GVENRAKLEARLRTLEDRGIR-KIS-GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
           G ++++K +   R  E+  ++ K++  TG   A  EK E  +  +  D  GD       K
Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED-DNEGDKK----KK 316

Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
            +K ++ +KE++  EKK   +K  VK  +E   K+ EEEE   +++++R K+    E   
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376

Query: 502 SEEEPCTSTAIASPEKKKKKKKKR 525
            EEE          ++K+K++K+R
Sbjct: 377 KEEERLEQEKRERKKQKEKERKER 400



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 41/180 (22%)

Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR------ 443
           KL  + +    +  +K  G+ +    ++K + +S + +   SGD +      ++      
Sbjct: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ 204

Query: 444 ------KIEQVDKEDE-------ITEKKAKKAKIKVKVEEEEE---EKVAEEEETSVKKK 487
                  IE  +++D+       + +KKA+K + + K  +EE+    K+ E+EE    KK
Sbjct: 205 KNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264

Query: 488 ---KKRGKKKHIKEE-------------PLSEEEPCTSTAIASP---EKKKKKKKKRENE 528
              K++  ++  +EE             P SEE+  T TA       +KKKK KKK++ E
Sbjct: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE 324



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 37/147 (25%), Positives = 71/147 (48%), Gaps = 6/147 (4%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSE---VKTYDPSGDSTLPTCSKK 442
           + R + +A+LR L+++   ++    K  +K ++ + K E   VK+        +P   +K
Sbjct: 241 KKRDEEKAKLRKLKEK--EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298

Query: 443 RKIEQVDKEDEITEKKAK-KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
            +     ++D   +KK K K K K + EE+E+EK     + +VK  ++   K   +EE  
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358

Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528
             EE      +   E K+K++++ E E
Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQE 385



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 23/161 (14%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
           +D+S  +    + K E + R  + R   K        AK  K + K E++T         
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEK--------AKLRKLKEKEELETGKKDQ---- 266

Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
              SK+++ ++  +E+ +  K      +    EE+ E   A E++    KKKK  KKK  
Sbjct: 267 ---SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323

Query: 497 KEEPLSEEE---PCTSTAIASPE-----KKKKKKKKRENED 529
           ++E   +E+   P  +T  A  E     K++++++KRE E+
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 22/170 (12%)

Query: 382 AMGVENRAK--LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD---PSGDSTL 436
           A GVE  +K  L  +    ED+  +KI    ++   +E  E  + V+  +   P  + T 
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487

Query: 437 PTCSKKRKIEQVDK---------EDEITEK-KAKKAKIKVKV-------EEEEEEKVAEE 479
           P    + + +  D           DE TEK +  K  I+VK        EEEEEE+  E 
Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547

Query: 480 EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           EE   ++ +  G +   ++E +S+E+    T    P K+     + +++D
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 36.2 bits (82), Expect = 0.076
 Identities = 25/96 (26%), Positives = 53/96 (55%), Gaps = 6/96 (6%)

Query: 408 GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIK-- 465
           G  K   K +K   K E +     G S     + +  + ++ KE+E  +K+ ++ +IK  
Sbjct: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL-KEEEERQKREEEERIKRL 369

Query: 466 --VKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
             ++ + +EEE++ E+E+   KK+K++ +K+ +K+E
Sbjct: 370 EELEAKRKEEERL-EQEKRERKKQKEKERKERLKKE 404



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 11/116 (9%)

Query: 422 KSEVKTYDPSGD----STLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA 477
           K +V+ Y  S D    + LP  +K +  +   K D   E +    KIK +       +  
Sbjct: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG 187

Query: 478 EEEETSVKKKKKRGKKKHIKEEP-----LSEEEPCTSTAIASPEKKKKKKKKRENE 528
           +E +  ++ +K  G+KK+ K +P        E+   S  I +  +KK +KK+RE +
Sbjct: 188 DESDEFLQSRK--GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 17/82 (20%), Positives = 45/82 (54%)

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           E+ ++++E  E++ ++ + +    +EE+EKV++E+++     KK  K+     E  S+++
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598

Query: 506 PCTSTAIASPEKKKKKKKKREN 527
                      K++ +K++ E+
Sbjct: 599 RTKEERAYDKAKRRIEKRRLEH 620



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 14/100 (14%)

Query: 441 KKRKIEQVDKEDEITEK-----------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK 489
           KK K +Q   ED+I ++           KA +  + VK  E  EE+   +++   KKK +
Sbjct: 45  KKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDK---KKKGQ 101

Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           +GKK+   +    E E   S +  + + K +     +++D
Sbjct: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 37/147 (25%), Positives = 61/147 (41%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
           E++ S    ++  K EA+        +++ + T +      K E KS  K   P    TL
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759

Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
              S + K    ++     +K  +KAK  VK E +  EK     +   K  +K   KK  
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819

Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKK 523
            + P+ EEE      +  P KK +++K
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEK 846



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 20/109 (18%)

Query: 430 PSGDSTLPTCS---------KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE- 479
           P G   +P+ S         K + +E+ +KE  I E++ ++ ++  +V EEEE++  EE 
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEE 482

Query: 480 --EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
             EE   ++++  G ++  K  P  E         ASPEK+ K   K E
Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEE--------AASPEKEAKSPVKEE 523



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 6/140 (4%)

Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
           K  A  +T E +  +K     K   K +  E K      +P+ +    +  + +K E  D
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK------EPAVEKPKESKVEAKKEEAED 899

Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509
           K+   T +K   AK++VK + + +EK    ++     K K   K   K+E   E++    
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959

Query: 510 TAIASPEKKKKKKKKRENED 529
                PE+K K + K + +D
Sbjct: 960 EKAKKPEEKPKTEAKAKEDD 979



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 2/147 (1%)

Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444
           V++  K E + + ++ +   K +   KA A  +  E K   K   P  ++  P   +K++
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879

Query: 445 IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA--EEEETSVKKKKKRGKKKHIKEEPLS 502
                 ++   E K ++A+ K KV   E+E  A  E +E +  K+K    KK   +    
Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939

Query: 503 EEEPCTSTAIASPEKKKKKKKKRENED 529
           E         A+PEKK  K++K +  +
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPE 966



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 7/107 (6%)

Query: 418 KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEE---EEE 474
           K + + ++K  + S   T+     + + E+    +E+TE++ K+AK +   EEE   EEE
Sbjct: 437 KVKSEEKIKVVEKSEKETVIV---EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEE 493

Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
               EEET     ++    +   + P+ EE    + A  SPEK++ K
Sbjct: 494 AEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA-KSPEKEEAK 539



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 2/109 (1%)

Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV-KVEEEEEEKVAE 478
           E K E K  +      +PT  K+   +   KED   ++K + AK +    + +E  K AE
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946

Query: 479 EEETSVKKK-KKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
           ++E + +KK  K  K K  +E+P +E +        S E  K K +K E
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 36/152 (23%), Positives = 68/152 (44%), Gaps = 13/152 (8%)

Query: 377  EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGK-ALAKTE-----KYEHKSEVKTYDP 430
            E    A+     +K+EA+    ED+  +K+    K A AK E     K + K+EV   +P
Sbjct: 876  EKKEPAVEKPKESKVEAKKEEAEDK--KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933

Query: 431  SGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKR 490
                         K E   ++ +  E+KAKK + K K E +     A+E++ ++ K+  +
Sbjct: 934  DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-----AKEDDKTLSKEPSK 988

Query: 491  GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
             K +  ++   ++++       A+ +K  K K
Sbjct: 989  PKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 10/116 (8%)

Query: 418 KYEHKSEVKTYDP-SGDSTLPT--CSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
           K E KS  K   P   D+  P     KK +++   KE+E    K ++ K+K   ++ EEE
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE----KPQEVKVKEPPKKAEEE 845

Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK--KKKKKRENE 528
           K     +T  KK  K+ +    KE P  + E     A+  P++ K   KK++ E++
Sbjct: 846 KAPATPKTEEKKDSKKEEAPK-KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 9/127 (7%)

Query: 411  KALAKTEKYEHKSEVKTYD---PSGDSTLPTCSKKRKIEQVDKEDEITEKK-----AKKA 462
            K  AK E+ E K +V T +   P+          K K E   KE +  + K     A+K 
Sbjct: 889  KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948

Query: 463  KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
            +   + ++ +EEK  + EE    + K +   K + +EP S+ +   +   +S ++K  K 
Sbjct: 949  EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP-SKPKAEKAEKSSSTDQKDSKP 1007

Query: 523  KKRENED 529
             ++  ED
Sbjct: 1008 PEKATED 1014



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 42/163 (25%), Positives = 64/163 (39%), Gaps = 20/163 (12%)

Query: 376 GEDSSSAMGVENRAKL----EARLRTLEDRGIRKISGTGKALAKT-EKYEHKSEVKTYDP 430
           G +   A G E   K     EA     E +   K      A AK+ EK E KS  +   P
Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547

Query: 431 SG-------DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETS 483
                    ++  P  +K  + E+     E+   +  K+  K + +   E K  E+ ++ 
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607

Query: 484 VKKKKKRGK--KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
           VK++ K     K  +KEE  S  E      + SPEK K   K+
Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAE------VKSPEKAKSPTKE 644



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 14/153 (9%)

Query: 385 VENRAKLEARLRTLED-RGIRKISGTGKALAKT-EKYEHKSEVKTYDP-SGDSTLPTCSK 441
           V+  AK  A +++ E  +   K        AK+ EK E KS  K   P   ++  P  +K
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681

Query: 442 ---KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKH--I 496
              K + +  +K     +++AK  + K K   +EE K  E+ ++ VK++ K  +K    +
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPE-KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740

Query: 497 KEEPLSEE-----EPCTSTAIASPEKKKKKKKK 524
           KEE  S E     E   +  + SPE K   K++
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 35/156 (22%), Positives = 63/156 (40%), Gaps = 27/156 (17%)

Query: 373 DAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSG 432
           D F E + S +  E ++  +A+    ED           A A  ++   K EVK+     
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKED-----------AKAPEKEIPKKEEVKS----- 822

Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
                   ++ K ++V  ++   + + +KA    K EE+++ K  E  +    K K   K
Sbjct: 823 -----PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877

Query: 493 KKHIKEEP------LSEEEPCTSTAIASPEKKKKKK 522
           K+   E+P        +EE      + +PEK+   K
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 38/147 (25%), Positives = 53/147 (36%), Gaps = 21/147 (14%)

Query: 399 EDRGIRKISGTGKALAKTE---KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT 455
           E +   K     KA AK+    K   K+E K+ + +            K +   KE+  +
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718

Query: 456 EKKAK-----------KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504
            +KAK           KAK  VK E +  EK    E+      K    K   KEE  S  
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778

Query: 505 EPCTSTA-------IASPEKKKKKKKK 524
           +     A       + SPEK K   K+
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKE 805



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 28/121 (23%), Positives = 49/121 (40%), Gaps = 9/121 (7%)

Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK-----KAKIKVK 467
           + + E+ E K E    +  G+       ++       +E    EK+AK     +AK   +
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529

Query: 468 VEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE----EEPCTSTAIASPEKKKKKKK 523
            +  E+E+     E    +K K   K+  K  P ++    EE  +   + SPEK K   K
Sbjct: 530 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589

Query: 524 K 524
           +
Sbjct: 590 E 590



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 34/151 (22%), Positives = 58/151 (38%), Gaps = 9/151 (5%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
           E++ S    ++  K EA+    E +   K     K  AK+       E +      +   
Sbjct: 522 EEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580

Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK--VAEEEETSVKKKKKRGKKK 494
           P  +K    E+     E    +  K+ +K + +   E K  V EE ++  + K     K 
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640

Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
             KEE  S E+        SPEK++ K  ++
Sbjct: 641 PTKEEAKSPEKA------KSPEKEEAKSPEK 665



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 27/151 (17%), Positives = 63/151 (41%), Gaps = 8/151 (5%)

Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR 443
           G+     +   ++   +  I+ +  + K     E+   +++V T + + +       ++ 
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEG 483

Query: 444 KIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK---- 497
           K E+  +E+E    E++ K    +     E+E K   +EE     + K  +K+  K    
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543

Query: 498 -EEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
            + P   + P    A + PE K  +K++ ++
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 36/141 (25%), Positives = 66/141 (46%), Gaps = 21/141 (14%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
           E   K + + +  ++RG     G  +   +  K E + E                ++RK 
Sbjct: 108 EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE----------------RERKK 151

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           E+ +KE E  E+K ++ K   +V E+EEE+  +E+E   +KK++R +K+  KE    E  
Sbjct: 152 EEREKERERKERKKRERK---QVGEKEEER--KEKERKERKKRERNRKERKKERERKERR 206

Query: 506 PCTSTAIASPEKKKKKKKKRE 526
                     E+KK+++K R+
Sbjct: 207 ERKKERKKKEERKKERQKDRQ 227



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 34/144 (23%), Positives = 68/144 (47%), Gaps = 3/144 (2%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
           E + + +   R  + R   K +  G+   K +K E K   +T   S +       ++RK 
Sbjct: 85  EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT---SKEGKERERKEERKR 141

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           E+  + +   E++ K+ + K + + E ++   +EEE   K++K+R K++  ++E   E E
Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201

Query: 506 PCTSTAIASPEKKKKKKKKRENED 529
                      KKK+++KK   +D
Sbjct: 202 RKERRERKKERKKKEERKKERQKD 225



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 9/121 (7%)

Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
           K  K E +SE K      +       K+RK E+  KE +   KK ++ + K + E+E +E
Sbjct: 49  KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108

Query: 475 KVAEEEETSVKKKKKR-------GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
              EE+E   KK+KK        GK++  KEE   EE           EK++++K++++ 
Sbjct: 109 --GEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166

Query: 528 E 528
           E
Sbjct: 167 E 167



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 12/90 (13%)

Query: 441 KKRKIE---QVDKEDEITEKKAKKAKIKVKVEEEEEEKV--AEEEETSVKKKKKRGKKKH 495
           ++R+IE   +  KE E   KK ++ + K K E E+E K    ++E+   +KK++R +KK 
Sbjct: 41  REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100

Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
            +E+   E E          ++KKK+KK+R
Sbjct: 101 RREKENKEGEE-------KEKRKKKEKKER 123



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 4/85 (4%)

Query: 444 KIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK----KKKKRGKKKHIKEE 499
           +I + ++E E  ++  K+ + + K E  E EK   E E   K    KK+K+G++K  + E
Sbjct: 37  EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96

Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
                    +      EK+KKK+KK
Sbjct: 97  RKKRRREKENKEGEEKEKRKKKEKK 121



 Score = 36.6 bits (83), Expect = 0.058
 Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 3/83 (3%)

Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK---HIKEEPLSEEE 505
           ++E EI  +K  K + + + ++E  E+   + E   ++K++RGKK+     K+E    ++
Sbjct: 40  EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99

Query: 506 PCTSTAIASPEKKKKKKKKRENE 528
                     E+K+K+KKK + E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKE 122



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 18/75 (24%), Positives = 44/75 (58%), Gaps = 4/75 (5%)

Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514
           +E + ++ +I+ + E ++E +   ++E   ++K+KR ++K  K E   +E+         
Sbjct: 36  SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK----KGERK 91

Query: 515 PEKKKKKKKKRENED 529
            E++++KK++RE E+
Sbjct: 92  KEERERKKRRREKEN 106



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 24/105 (22%), Positives = 47/105 (44%)

Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447
           R + + R R  E+R   +     K   + +  E + E K  +           K+RK E+
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200

Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
             KE    +K+ KK + + K  +++ +    E+E   +++K+R K
Sbjct: 201 ERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 16/162 (9%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
           E+   A     R K E + R  E+R  ++I    K  A+ E+   K E K          
Sbjct: 319 EEEKRAAEERQRIKEEEK-RAAEER--QRIKEEEKRAAE-ERQRIKEEEKRAAEERQRAR 374

Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE--------EKVAEEEETSVKKKK 488
               +K K+E+  +  ++ EKK    + K+K E+ E+        EK A+E++      K
Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434

Query: 489 KRGKKK----HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
           K+G++K      K E L E++P         EK KK K+ +E
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 4/116 (3%)

Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEE 470
           K+ ++ E+YE + E +T   S        +++ K E  +KE+E  EK  + +  + +VE 
Sbjct: 152 KSESRQERYEIE-ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEV 210

Query: 471 EEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE-PCTSTAIASPEKKKKKKKKR 525
             EEK  E +E +V    K G+     EEP  EEE    S  I+  EK +++ K+R
Sbjct: 211 MVEEKTTESQEETVVMSLKNGQIS--SEEPKQEEEREQGSDEISHHEKMEEEDKER 264



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 28/146 (19%), Positives = 64/146 (43%), Gaps = 11/146 (7%)

Query: 383 MGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKK 442
           M  E++ + EA    LE     +I          E+   ++E K             +++
Sbjct: 257 MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA-----------AAQE 305

Query: 443 RKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS 502
           R+  + ++ + + E++ + A+ + +++EEE+    E +    ++K+   +++ IKEE   
Sbjct: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365

Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528
             E          EK K +++KR  +
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQ 391



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 10/155 (6%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
           E+   A     R K E + R  E+R   +     KA  + +K   + E K +     +  
Sbjct: 347 EEEKRAAEERQRIKEEEK-RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH-----AMQ 400

Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIK---VKVEEEEEEKVAEEEETSVKKKKKRGKK 493
            T  K  K+EQ  +   + EKKA++ K++   +K + EE+    + +   +++ K   KK
Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460

Query: 494 KHIKEEPL-SEEEPCTSTAIASPEKKKKKKKKREN 527
           + IK+E +  ++EP          KK   + K +N
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495



 Score = 35.8 bits (81), Expect = 0.099
 Identities = 20/90 (22%), Positives = 46/90 (51%)

Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
           S   K+E+ DKE    E+   +A+ + +++ E+++K+A+E      ++K   +++  +E 
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311

Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENED 529
              E         A   ++ K+++KR  E+
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEE 341



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 3/82 (3%)

Query: 426 KTYDPS-GDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV 484
           K +DP+  D++L   S  R+++    E+E TEK+ K    + + E EE E V +  + + 
Sbjct: 119 KEFDPTITDASLSLPS--RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176

Query: 485 KKKKKRGKKKHIKEEPLSEEEP 506
            +  +  KK+  ++E   EE+P
Sbjct: 177 WRDAEENKKEDKEKEEEEEEKP 198



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 33/165 (20%), Positives = 77/165 (46%), Gaps = 21/165 (12%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKTYDPSGDSTLPTCSKKR 443
           + RA++EA  +       R+ +   + + + EK   E +  +K  +           ++ 
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349

Query: 444 KI-----EQVDKEDEITEKKAKKAKI----KVKVEEEEEEKVAEEEETSVKKKKKRGKK- 493
           K      +++ +E++   ++ ++A+     K KVEE++  K  EE++ ++++ K +G+K 
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409

Query: 494 ------KHIKEEPLSEEEPCTSTAIASPEKKKKK---KKKRENED 529
                 K + E+   E++  T+      E+K  K   K+++  ED
Sbjct: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454



 Score = 33.1 bits (74), Expect = 0.64
 Identities = 24/92 (26%), Positives = 49/92 (53%), Gaps = 4/92 (4%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKV---KVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
           ++R+ E   +E E  ++K ++A +++   K + EE  KV EEEE   +K+++  +K   +
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR-RKQEEADRKLREE 598

Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           EE    +E        + EK++K  +   ++D
Sbjct: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 630



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 25/114 (21%), Positives = 57/114 (50%), Gaps = 6/114 (5%)

Query: 416 TEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK 475
           T K +H +E     P G +++ T  +     QV+    + E + ++ +     E EE EK
Sbjct: 500 THKLKH-TENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGE----TESEEFEK 553

Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           + ++++ +  + ++  KK+  + + L EEE       A  + +++++K+R  E+
Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 10/119 (8%)

Query: 393 ARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDST------LPTCSKKRKIE 446
           A + T E  G  ++   GK L +  +   ++E + ++            L    KKR+  
Sbjct: 517 ASVDTKEAEGAPQVEA-GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575

Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           +   E+E   +K ++A  K++   EEEEK   +EE   ++ +   K++ + E+ LS+++
Sbjct: 576 RKVLEEEEQRRKQEEADRKLR---EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 22/111 (19%), Positives = 53/111 (47%), Gaps = 4/111 (3%)

Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV----KVEEEEEEK 475
           E++ EV   + + +S   T     K  Q+  E+   E++ ++   ++    K+EEE++E+
Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKER 264

Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
              E      ++++R K +  K+              A+ E+++++ ++RE
Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315


>gi|239750213 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 248

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 25/86 (29%), Positives = 46/86 (53%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
           +K+K  +  K+ + T KK KK   K K   + +++    ++T+    K++ K+K  ++E 
Sbjct: 27  RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86

Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526
             E+E          +KKKKKKKK++
Sbjct: 87  EKEKEKEKEKEKKKKKKKKKKKKKKK 112



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 26/80 (32%), Positives = 42/80 (52%)

Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476
           +K + K+ +K    +      T   K++     K    T K+ +K K K K +E+E+EK 
Sbjct: 34  KKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKE 93

Query: 477 AEEEETSVKKKKKRGKKKHI 496
            E+E+   KKKKK+ KKK +
Sbjct: 94  KEKEKKKKKKKKKKKKKKKL 113



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 1/88 (1%)

Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
           G+    T+K + K           +   T +K +K     K+   T  K K+ K K K +
Sbjct: 26  GRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE-KEKEKEK 84

Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIK 497
           E+E+EK  E+E+   KKKKK+ KKK  K
Sbjct: 85  EKEKEKEKEKEKEKKKKKKKKKKKKKKK 112



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 7/111 (6%)

Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476
           EK    +E ++    G     T  KK+K   + K+ + T KK    K K +    ++   
Sbjct: 11  EKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTT 70

Query: 477 AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
              +E   +K+K++ K+K  ++E   E++          +KKKKKKKK+ N
Sbjct: 71  TTTKEKEKEKEKEKEKEKEKEKEKEKEKK-------KKKKKKKKKKKKKLN 114



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 1/71 (1%)

Query: 438 TCSKKRKIEQVDKEDEITEKKAKKA-KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
           T +KK+   +  K    T+K      K K K +E+E+EK  E+E+   K+KKK+ KKK  
Sbjct: 48  TTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKEKEKEKKKKKKKKKK 107

Query: 497 KEEPLSEEEPC 507
           K++     + C
Sbjct: 108 KKKKKLNAKVC 118



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 25/90 (27%), Positives = 42/90 (46%)

Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAK 463
           RK   T K   K    + K +  T   +   T    +  +K      +++  EK+ +K K
Sbjct: 27  RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86

Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKK 493
            K K +E+E+EK  ++++   KKKKK   K
Sbjct: 87  EKEKEKEKEKEKKKKKKKKKKKKKKKLNAK 116



 Score = 36.2 bits (82), Expect = 0.076
 Identities = 25/86 (29%), Positives = 48/86 (55%), Gaps = 9/86 (10%)

Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI-----KEEPLS 502
           ++K   ITEK++   + + K   ++++K    ++T++KKKKK   KK       K    +
Sbjct: 10  MEKVHVITEKESAWKRGRKKKTTKKKKK----KKTTMKKKKKTTTKKKTTTKTKKRTTTT 65

Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528
           ++   T+T     EK+K+K+K++E E
Sbjct: 66  KKTTTTTTKEKEKEKEKEKEKEKEKE 91



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 12/85 (14%)

Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE----------- 504
           +K     K+ V  E+E   K   +++T+ KKKKK+   K  K+    ++           
Sbjct: 5   DKGVAMEKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTT 64

Query: 505 -EPCTSTAIASPEKKKKKKKKRENE 528
            +  T+T     EK+K+K+K++E E
Sbjct: 65  TKKTTTTTTKEKEKEKEKEKEKEKE 89



 Score = 33.5 bits (75), Expect = 0.49
 Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 2/93 (2%)

Query: 401 RGIRKISGTGKALAKTE-KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459
           RG +K +   K   KT  K + K+  K    +      T +KK       ++++  EK+ 
Sbjct: 25  RGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEK 84

Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
           +K K K K E+E+E+K  ++++   KKKK   K
Sbjct: 85  EKEKEKEK-EKEKEKKKKKKKKKKKKKKKLNAK 116



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 18/74 (24%), Positives = 37/74 (50%), Gaps = 8/74 (10%)

Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515
           +KK  K K K K   ++++K   +++T+ K KK+    K        E+E          
Sbjct: 28  KKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE--------KE 79

Query: 516 EKKKKKKKKRENED 529
           ++K+K+K+K + ++
Sbjct: 80  KEKEKEKEKEKEKE 93


>gi|11225260 DNA topoisomerase I [Homo sapiens]
          Length = 765

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 38/148 (25%), Positives = 66/148 (44%), Gaps = 21/148 (14%)

Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEK---YEHKSEVKTYDPSGDSTLPTCS 440
           G   + K + + R  E R   K+  +G A  K EK   +    ++K  +P  D       
Sbjct: 72  GSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKD-EPEDDGYFVPPK 130

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
           +  K  +  ++++  + K KK K +   ++E++ K+ EEE+  +KK K + K K + E  
Sbjct: 131 EDIKPLKRPRDEDDADYKPKKIKTE-DTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPE-- 187

Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528
                         P+ KKKK KK E +
Sbjct: 188 --------------PDNKKKKPKKEEEQ 201



 Score = 37.7 bits (86), Expect = 0.026
 Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 10/120 (8%)

Query: 415 KTEKYEHKSEVKTYDPS----GDSTLPTCSKKRKIEQVDK-EDEITEKKAKKAKIKVKVE 469
           K  ++ HK   K  D       +S      KK K ++  K +D  +EK   K K + K E
Sbjct: 29  KDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDK-E 87

Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
           + +EEKV    +  +KK+K+ G        P  ++EP        P++  K  K+  +ED
Sbjct: 88  KRKEEKVRASGDAKIKKEKENG----FSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDED 143



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKVAEEEETSVKKKKKRGKKKH 495
           S K K +  D+E    E K +K + K K    E    E+K  E+E+T  K K    +K  
Sbjct: 21  SHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKT--KHKDGSSEKHK 78

Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
            K +   +E+       AS + K KK+K+
Sbjct: 79  DKHKDRDKEKRKEEKVRASGDAKIKKEKE 107



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 9/84 (10%)

Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV--KKKKKRGKKKHIKEEPLSEE 504
           Q++ +  + +    K K K +    +E K  ++ E S     + K  +KKH ++E    +
Sbjct: 11  QIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHK 70

Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528
           +        S EK K K K R+ E
Sbjct: 71  D-------GSSEKHKDKHKDRDKE 87


>gi|46276863 parathymosin [Homo sapiens]
          Length = 102

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 25/80 (31%), Positives = 46/80 (57%), Gaps = 1/80 (1%)

Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK-KKKKRGKKKHIKEEPLSEEEPC 507
           +K++++ EK ++K + K  VEEEE     EEEET+   +++  G+++  +EE   +E P 
Sbjct: 19  EKKEKVEEKASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGEEEDEEEEEEDDEGPA 78

Query: 508 TSTAIASPEKKKKKKKKREN 527
              A    ++   K++K EN
Sbjct: 79  LKRAAEEEDEADPKRQKTEN 98



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 6/68 (8%)

Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
           A++  K  +E++EKV E      K  +K  KK+ ++EE    EE    TA    E+ + +
Sbjct: 10  AELSAKDLKEKKEKVEE------KASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGE 63

Query: 522 KKKRENED 529
           ++  E E+
Sbjct: 64  EEDEEEEE 71


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 15/130 (11%)

Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA---------KKAK 463
           L K E ++ K+E +        T  T  +K K ++  +E E  EKKA         +K +
Sbjct: 138 LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE 197

Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523
            K   +E+++ K AE+ E   KK+ K GK++ +K+     +E       + P++K+ K+K
Sbjct: 198 TKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKE--VQKTPSKPKEKEDKEK 255

Query: 524 ----KRENED 529
               K E +D
Sbjct: 256 AAVSKHEQKD 265



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 44/191 (23%), Positives = 81/191 (42%), Gaps = 14/191 (7%)

Query: 346 LVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRK 405
           +  +T  K K  I +    +T + +     G+ S +  G     K+ A+    +D   ++
Sbjct: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT---VKIAAQAAAKKDEK-KE 378

Query: 406 ISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK---- 461
            S   K  A+ E+ + K + K       +  P   KK      DK+ +   ++AK+    
Sbjct: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSP---KKEHSVPSDKQVKAKTERAKEEIGA 435

Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLS--EEEPCTSTAIASPEKK 518
             IK  V  ++EEK  +  E  ++K+K       +K+ EP+   EE+   S     PE K
Sbjct: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495

Query: 519 KKKKKKRENED 529
           K +K  +  ++
Sbjct: 496 KDEKMSKAGKE 506



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 430 PSGDSTLPT--CSKKRKIEQVDKEDEITEKKA-KKAKIKVKVEEEEEEKVAEEEETSVK- 485
           P+    LPT   S+        +E E  +KKA KK   + K +E+E+ K   E+ET++  
Sbjct: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347

Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
           +KK+ GK    K+  +       +      E  KK KK  E E
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 31/94 (32%), Positives = 48/94 (51%), Gaps = 13/94 (13%)

Query: 446 EQVDKEDEITEKKAKKAKI-KVKVEEEEE----------EKVAEEEETSVKKKKKRGKKK 494
           E  DK  EI E   +K +I K K E++E+           K  E+ +  V++K+K  KK 
Sbjct: 126 EDTDK-GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184

Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
             KE+   +E+P T T +A  +KK K  +K E +
Sbjct: 185 THKEKIEKKEKPETKT-LAKEQKKAKTAEKSEEK 217



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 1/86 (1%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
           KK   E   KE E  +KK++K +  + VE++E  K +E ++ +VK   +   KK  K+E 
Sbjct: 321 KKVTSETKKKEKEDIKKKSEK-ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKED 379

Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526
             + +          +K++KK+K  E
Sbjct: 380 SKKTKKPAEVEQPKGKKQEKKEKHVE 405



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 30/114 (26%), Positives = 58/114 (50%), Gaps = 12/114 (10%)

Query: 386 ENRAKLEARLRTL-----EDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCS 440
           E + K E +++T      +++G  K+    K     +K  HK +++  +     TL    
Sbjct: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKP---EKKATHKEKIEKKEKPETKTL--AK 203

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK 494
           +++K +  +K +E T+K+ K  K + KV ++   KV E ++T  K K+K  K+K
Sbjct: 204 EQKKAKTAEKSEEKTKKEVKGGK-QEKV-KQTAAKVKEVQKTPSKPKEKEDKEK 255



 Score = 33.1 bits (74), Expect = 0.64
 Identities = 31/125 (24%), Positives = 54/125 (43%), Gaps = 7/125 (5%)

Query: 412 ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ-VDKEDEITEKKAKKAKIKVKVEE 470
           AL + E  + K+E K    +         KK + E  +D E +   K ++  +  VK+  
Sbjct: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367

Query: 471 EEEEKVAEEEETSVKKKKK------RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
           +   K  E++E S K KK       +GKK+  KE+ +   +          +K+ K K +
Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427

Query: 525 RENED 529
           R  E+
Sbjct: 428 RAKEE 432



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 9/132 (6%)

Query: 398 LEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457
           LE++   K     K  ++T+K E K ++K      +       +K++  +  +  + T K
Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKE-KEDIKK---KSEKETAIDVEKKEPGKASETKQGTVK 364

Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKK-KHIKEEPLSEEEPCTSTAIASPE 516
            A +A  K   ++E+ +K  +  E    K KK+ KK KH+  EP   + P    ++ S +
Sbjct: 365 IAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV--EP--AKSPKKEHSVPSDK 420

Query: 517 KKKKKKKKRENE 528
           + K K ++ + E
Sbjct: 421 QVKAKTERAKEE 432



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 14/135 (10%)

Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
           K E   +T+E    ++ SG   ++ K +K   K + +    S     P   K  K+ +  
Sbjct: 446 KEEKTTKTVEQEIRKEKSGKTSSILK-DKEPIKGKEEKVPASLKEKEPETKKDEKMSKAG 504

Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509
           KE      K K  +++ K EE+ E ++ +E + ++ +K +  K+  +K E         +
Sbjct: 505 KE-----VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK--------T 551

Query: 510 TAIASPEKKKKKKKK 524
            +   PE+K  K+ K
Sbjct: 552 VSHGKPEEKVLKQVK 566



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 2/108 (1%)

Query: 422 KSEVKTYDPSGDSTLPTCSKKRKIEQVD-KEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480
           K E K        T+   +K +  ++ + +E E    K  K K   K   E  E   ++ 
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615

Query: 481 ETSVKKKKKRGKKKHIKEEPLS-EEEPCTSTAIASPEKKKKKKKKREN 527
           E S K+ K++   KH++EE +S  +E      +   EK  +  K  E+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVED 663


>gi|4503337 dyskerin isoform 1 [Homo sapiens]
          Length = 514

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/85 (34%), Positives = 42/85 (49%)

Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
           +KK  + +V K  ++  + AK AK K + E E +E      +   K+KKK  K K  K  
Sbjct: 423 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 482

Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
             S  EP    +  + +KKKKKK K
Sbjct: 483 LESGAEPGDGDSDTTKKKKKKKKAK 507



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)

Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
           AKT K + +SE ++     D T P         Q+ K+++   KK KKAK    +E   E
Sbjct: 442 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 488

Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499
               + + T  KKKKK+ K+  +  E
Sbjct: 489 PGDGDSDTTKKKKKKKKAKEVELVSE 514



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 459 AKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKK 518
           ++ AK +V  E  +  +V  E   + K+K++         E  S+E P  +  +   EKK
Sbjct: 420 SESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--------SESESDETPPAAPQLIKKEKK 471

Query: 519 KKKKKKR 525
           K KK K+
Sbjct: 472 KSKKDKK 478


>gi|215599015 dyskerin isoform 2 [Homo sapiens]
          Length = 509

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/85 (34%), Positives = 42/85 (49%)

Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
           +KK  + +V K  ++  + AK AK K + E E +E      +   K+KKK  K K  K  
Sbjct: 418 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 477

Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
             S  EP    +  + +KKKKKK K
Sbjct: 478 LESGAEPGDGDSDTTKKKKKKKKAK 502



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)

Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
           AKT K + +SE ++     D T P         Q+ K+++   KK KKAK    +E   E
Sbjct: 437 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 483

Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499
               + + T  KKKKK+ K+  +  E
Sbjct: 484 PGDGDSDTTKKKKKKKKAKEVELVSE 509



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 27/93 (29%), Positives = 44/93 (47%), Gaps = 16/93 (17%)

Query: 441 KKRKIEQ--VDKEDEITE------KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
           KK  I+Q  +DK  + T+      K+ + AK +V  E  +  +V  E   + K+K++   
Sbjct: 389 KKLMIKQGLLDKHGKPTDSTPATWKQDESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--- 445

Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
                 E  S+E P  +  +   EKKK KK K+
Sbjct: 446 -----SESESDETPPAAPQLIKKEKKKSKKDKK 473


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 8/149 (5%)

Query: 388 RAKLEARLRTLEDRGI------RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
           R K E + R   +RG       ++     K   + E+ + K E K  +           K
Sbjct: 58  RGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKK 117

Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK--RGKKKHIKEE 499
           K + E+  +  +  E+K KK + K + +E + EK   + E   KK+KK  R KK+    +
Sbjct: 118 KERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177

Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENE 528
              +E           E+KK+++KK+E +
Sbjct: 178 ERKKERERKERRERKKERKKERRKKKERK 206



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 21/141 (14%)

Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447
           R K   R R  +++  RK    GK   +  K   K   +  +           +KRK E+
Sbjct: 50  REKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE--------RRKRKKEK 101

Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPC 507
             +E +   ++ +K K K + E E E K   E +   ++KKKR K++  ++E        
Sbjct: 102 KKRERKQRGRRERKKK-KERKERERENKQRRERKRKKRRKKKRRKERKREKER------- 153

Query: 508 TSTAIASPEKKKKKKKKRENE 528
                   E+K+KK+KK E E
Sbjct: 154 -----GKRERKRKKRKKEERE 169



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/89 (31%), Positives = 46/89 (51%), Gaps = 13/89 (14%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
           K+RK E+  KE +   KK ++ K + +  +E E++  E  E   +K+KK  KK+  K+  
Sbjct: 52  KERKRERGKKEKK-KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRG 110

Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENED 529
             E             KKKK++K+RE E+
Sbjct: 111 RRE------------RKKKKERKEREREN 127



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 14/143 (9%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
           E R K   + +  + +  RK  G  +   K E+ E + E K              KKR+ 
Sbjct: 88  ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK-------QRRERKRKKRRK 140

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           ++  KE +  +++ K+ + + K ++EE EK  E      KK+++R +++  K+E   E  
Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200

Query: 506 PCTSTAIASPEKKKKKKKKRENE 528
                     E+KK +K  R+ +
Sbjct: 201 K-------KKERKKDRKTDRQTD 216



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 21/74 (28%), Positives = 39/74 (52%)

Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514
           +E+K ++ + + +  E E+E+  E  +   KK+KKR + K  + +    E+         
Sbjct: 34  SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93

Query: 515 PEKKKKKKKKRENE 528
             K+KK+KKKRE +
Sbjct: 94  RRKRKKEKKKRERK 107



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 7/88 (7%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
           +KRK E+ +KE +    K +K K K +   +E E+  +E E   K+++++ ++K  KE+ 
Sbjct: 44  EKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKK 102

Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528
             E +           ++KKKK+++E E
Sbjct: 103 KRERKQ------RGRRERKKKKERKERE 124



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 5/77 (6%)

Query: 453 EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLSEEEPCTSTA 511
           E   KK ++ + K K E E+E K     E   K+KKKR K++  KE E   +E       
Sbjct: 33  ESERKKERREREKRKREREKERK----RERGKKEKKKRKKRERGKERERKRKEREKQRKE 88

Query: 512 IASPEKKKKKKKKRENE 528
               E++K+KK+K++ E
Sbjct: 89  RREKERRKRKKEKKKRE 105



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 14/120 (11%)

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
           E + K E + R  E++  R+     +   K  K + + E K     G        KKRK 
Sbjct: 113 ERKKKKERKERERENKQRRE-----RKRKKRRKKKRRKERKREKERGKRERKR--KKRKK 165

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
           E+ +K+ E   K+ KK       E E +E+   ++E   +++KK+ +KK  K +  ++ +
Sbjct: 166 EEREKKRERNRKERKK-------ERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 29/223 (13%)

Query: 336 PKYGL---IYHASLVG---QTSPKHKGKISRMLAAKTVLAIRYD----AFGEDSSSAMGV 385
           PKYGL   ++  + +G    T  K K    R + A T  +++      +    SS A  V
Sbjct: 267 PKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSV 326

Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKAL-AKTEKYEHKSEVKTY-DPSGDSTLPTCSKKR 443
            +R      L     R  RKISGT     A  EK +H  ++    D          S   
Sbjct: 327 SSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG 386

Query: 444 KIEQV-----DKEDE-ITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
           +IEQ      D  D+ + E +AK  +++  VE  + EKV    +   +K+K    +  ++
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446

Query: 498 EEPLSEEEPCTSTAIASP-----------EKKKKKKKKRENED 529
           EE +++ +  T T +              EK K  K +RE ED
Sbjct: 447 EESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED 489



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 29/144 (20%), Positives = 59/144 (40%), Gaps = 30/144 (20%)

Query: 386  ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
            +  AKL+  L TL++  ++ +          E+     E+ T +             +K+
Sbjct: 1103 QTNAKLQNELDTLKENNLKNV----------EELNKSKELLTVE------------NQKM 1140

Query: 446  EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
            E+  KE E  ++ A +   ++   +EE  K+AEE          R + +    + L EE 
Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE--------LGRSRDEVTSHQKLEEER 1192

Query: 506  PCTSTAIASPEKKKKKKKKRENED 529
               +  +   +K++ K  K  +E+
Sbjct: 1193 SVLNNQLLEMKKRESKFIKDADEE 1216


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 50/204 (24%), Positives = 82/204 (40%), Gaps = 26/204 (12%)

Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
           QTS   +GK   +  A       Y  +  DS   + VE R +  A+ +  E+R +R+   
Sbjct: 454 QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK--EERLLRRQIN 511

Query: 409 TGKALAKTEKYEHKSEVK--------TYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460
             K   K ++   K++          + D    ST     K  +I++V KE ++ EKK  
Sbjct: 512 REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA 571

Query: 461 KAKIKVK----VEEEEEEKVAEEEETSVKKK------------KKRGKKKHIKEEPLSEE 504
            +K + K    VEE  ++K   EE++    K             K  K  H K EP    
Sbjct: 572 LSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPA 631

Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528
              + +     E K + K +RE++
Sbjct: 632 RRLSESLHVVDENKNESKLEREHK 655



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 24/96 (25%), Positives = 47/96 (48%), Gaps = 11/96 (11%)

Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRG--------- 491
           +KR+ + + +E  + + K+K    +VKV E E ++ A ++ T+ K  K++          
Sbjct: 896 EKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955

Query: 492 KKKHIKEEPLSEE--EPCTSTAIASPEKKKKKKKKR 525
           +K  ++++P  E   EP   TA +S    +K    R
Sbjct: 956 RKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 18/163 (11%)

Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKT-----YD 429
           E   S +G + +   E  ++T  D  +RK +   +     EK   EHKS   +      D
Sbjct: 796 ERKLSVLGKDGKPVSEYIIKT--DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKD 853

Query: 430 PSGDS----TLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK 485
             G      TL   S+    ++ D +    +   K  ++ V  E+   + + EE+     
Sbjct: 854 SLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEV-VHKEKRRTKSLLEEKLVLKS 912

Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
           K K +GK+  + E  L E     +T  A+  K  K+K   EN+
Sbjct: 913 KSKTQGKQVKVVETELQE----GATKQATTPKPDKEKNTEEND 951



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 32/129 (24%), Positives = 57/129 (44%), Gaps = 20/129 (15%)

Query: 396 RTLEDRGIRKISGT---GKALAKTEKYEHKS-------EVKTYDPSGDSTLPTCSKKRKI 445
           RT ED   ++ S     G+ L    K E  S       E+K Y    ++ +   +K  + 
Sbjct: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLI-LLNKDVQQ 309

Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE---------EETSVKKKKKRGKKKHI 496
           E  +++++ T+K  KK     K E ++E+K   E         E+T   K +K+ K+K +
Sbjct: 310 ESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV 369

Query: 497 KEEPLSEEE 505
           +   L  E+
Sbjct: 370 ESLKLPSEK 378



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 24/123 (19%), Positives = 53/123 (43%), Gaps = 6/123 (4%)

Query: 407  SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---EKKAKKAK 463
            S T   +   E+    S++K       +      ++R I   D E++I     ++ +K K
Sbjct: 2893 SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPK 2952

Query: 464  IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKK 520
              + V ++ E    E   ++  S   + K+ ++   +EE   E+EP  +T  ++   + +
Sbjct: 2953 RSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQ 3012

Query: 521  KKK 523
            + K
Sbjct: 3013 RSK 3015



 Score = 29.3 bits (64), Expect = 9.3
 Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 5/79 (6%)

Query: 449 DKEDEITEKKAK---KAKIKVKVEEEEEEKVAEEEETSVK--KKKKRGKKKHIKEEPLSE 503
           D + E +E+K K   K + K    E+ E K  ++E+T  K    KK    + +K+E  ++
Sbjct: 306 DVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAK 365

Query: 504 EEPCTSTAIASPEKKKKKK 522
           E+   S  + S +   K K
Sbjct: 366 EKEVESLKLPSEKNSNKAK 384


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 6/154 (3%)

Query: 370 IRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD 429
           I+  A  ++S  A      +KL  R   +E+      S   K LAKTEK   +S  K   
Sbjct: 313 IKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEK--- 369

Query: 430 PSGDSTLPTCSKKRKIEQVDKED-EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKK 488
           P      P   K    E +  E  ++ + K  K  +K K+ + EE+K  E++E  +KK++
Sbjct: 370 PPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKE--IKKER 427

Query: 489 KRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
           K  KK   ++E   + +         PE KK  K
Sbjct: 428 KELKKDEGRKEEKKDAKKEEKRKDTKPELKKISK 461



 Score = 37.4 bits (85), Expect = 0.034
 Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 11/90 (12%)

Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK-----RGKKKHI 496
           K    ++ KE   TEKKAK++  K   +  + E+V  E   ++K +K+     +  KKH+
Sbjct: 346 KEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHL 405

Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
           KE+    EE          EKK+ KK+++E
Sbjct: 406 KEKISKLEEK------KDKEKKEIKKERKE 429



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 30/120 (25%), Positives = 49/120 (40%), Gaps = 4/120 (3%)

Query: 411 KALAKTEKYEH----KSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
           K L   EK  H    +  V T        +PT  K  KI+Q     E  +   K A  K+
Sbjct: 275 KILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKL 334

Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
              EE  E+ A+E  + + K+  + +KK  +      E+P     + +   +  K +KR+
Sbjct: 335 AKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRK 394



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 24/84 (28%), Positives = 46/84 (54%), Gaps = 8/84 (9%)

Query: 441  KKRKIEQVDK----EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
            K   +EQ DK    +D+  E+K K  + K K+ E E++K  E+++T++++K K  +    
Sbjct: 1418 KDTALEQKDKALEPKDKDLEEKDKALEQKDKIPE-EKDKALEQKDTALEQKDKALEP--- 1473

Query: 497  KEEPLSEEEPCTSTAIASPEKKKK 520
            K++ L +++         PE+K K
Sbjct: 1474 KDKDLEQKDRVLEQKEKIPEEKDK 1497


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 404  RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
            RK+SG   A A+T + + K ++   +    S  P   + + K K ++     ++ EKK K
Sbjct: 1271 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1329

Query: 461  KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
             +      ++E EE++ +   T          S K+KKK  K+K  KE  E   + +  +
Sbjct: 1330 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1389

Query: 509  STAIASPEKKKKKKKKRENE 528
            +    SP +KKKKKKK+  E
Sbjct: 1390 TKDSESPSQKKKKKKKKTAE 1409



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)

Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
           VG  +P+  G  +    +   +A       EDSSS+   ++           E  G+   
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634

Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
            G  K++ K  + +  S V      G  T P    K           +T+ KA+K +   
Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685

Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
             E  EEE  +EE   S  + K   KK   K  P +   P     I++P K
Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)

Query: 349  QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
            +TS   KGK  R  A+  V   +    G+ S  + G ++  + E +      +G+  + G
Sbjct: 1305 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1354

Query: 409  TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
              ++  K++K + KS+                 KRK ++  KE    +KKAKKA  K   
Sbjct: 1355 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1391

Query: 469  EEEEEEKVAEEEETSVKKKKKRGK 492
                     + E  S KKKKK+ K
Sbjct: 1392 ---------DSESPSQKKKKKKKK 1406



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)

Query: 458  KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
            +A   K+  ++ E+E +KV +  + S +K  +  K+K      LS ++P   T    P  
Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1285

Query: 518  KKKKK 522
            KKKKK
Sbjct: 1286 KKKKK 1290


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 404  RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
            RK+SG   A A+T + + K ++   +    S  P   + + K K ++     ++ EKK K
Sbjct: 1310 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1368

Query: 461  KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
             +      ++E EE++ +   T          S K+KKK  K+K  KE  E   + +  +
Sbjct: 1369 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1428

Query: 509  STAIASPEKKKKKKKKRENE 528
            +    SP +KKKKKKK+  E
Sbjct: 1429 TKDSESPSQKKKKKKKKTAE 1448



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)

Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
           VG  +P+  G  +    +   +A       EDSSS+   ++           E  G+   
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711

Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
            G  K++ K  + +  S V      G  T P    K           +T+ KA+K +   
Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762

Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
             E  EEE  +EE   S  + K   KK   K  P +   P     I++P K
Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)

Query: 349  QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
            +TS   KGK  R  A+  V   +    G+ S  + G ++  + E +      +G+  + G
Sbjct: 1344 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1393

Query: 409  TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
              ++  K++K + KS+                 KRK ++  KE    +KKAKKA  K   
Sbjct: 1394 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1430

Query: 469  EEEEEEKVAEEEETSVKKKKKRGK 492
                     + E  S KKKKK+ K
Sbjct: 1431 ---------DSESPSQKKKKKKKK 1445



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)

Query: 458  KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
            +A   K+  ++ E+E +KV +  + S +K  +  K+K      LS ++P   T    P  
Sbjct: 1275 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1324

Query: 518  KKKKK 522
            KKKKK
Sbjct: 1325 KKKKK 1329


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 404  RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
            RK+SG   A A+T + + K ++   +    S  P   + + K K ++     ++ EKK K
Sbjct: 1347 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1405

Query: 461  KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
             +      ++E EE++ +   T          S K+KKK  K+K  KE  E   + +  +
Sbjct: 1406 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1465

Query: 509  STAIASPEKKKKKKKKRENE 528
            +    SP +KKKKKKK+  E
Sbjct: 1466 TKDSESPSQKKKKKKKKTAE 1485



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)

Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
           VG  +P+  G  +    +   +A       EDSSS+   ++           E  G+   
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711

Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
            G  K++ K  + +  S V      G  T P    K           +T+ KA+K +   
Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762

Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
             E  EEE  +EE   S  + K   KK   K  P +   P     I++P K
Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)

Query: 349  QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
            +TS   KGK  R  A+  V   +    G+ S  + G ++  + E +      +G+  + G
Sbjct: 1381 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1430

Query: 409  TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
              ++  K++K + KS+                 KRK ++  KE    +KKAKKA  K   
Sbjct: 1431 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1467

Query: 469  EEEEEEKVAEEEETSVKKKKKRGK 492
                     + E  S KKKKK+ K
Sbjct: 1468 ---------DSESPSQKKKKKKKK 1482



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)

Query: 458  KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
            +A   K+  ++ E+E +KV +  + S +K  +  K+K      LS ++P   T    P  
Sbjct: 1312 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1361

Query: 518  KKKKK 522
            KKKKK
Sbjct: 1362 KKKKK 1366


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)

Query: 404  RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
            RK+SG   A A+T + + K ++   +    S  P   + + K K ++     ++ EKK K
Sbjct: 1270 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1328

Query: 461  KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
             +      ++E EE++ +   T          S K+KKK  K+K  KE  E   + +  +
Sbjct: 1329 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1388

Query: 509  STAIASPEKKKKKKKKRENE 528
            +    SP +KKKKKKK+  E
Sbjct: 1389 TKDSESPSQKKKKKKKKTAE 1408



 Score = 34.3 bits (77), Expect = 0.29
 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)

Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
           VG  +P+  G  +    +   +A       EDSSS+   ++           E  G+   
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634

Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
            G  K++ K  + +  S V      G  T P    K           +T+ KA+K +   
Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685

Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
             E  EEE  +EE   S  + K   KK   K  P +   P     I++P K
Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)

Query: 349  QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
            +TS   KGK  R  A+  V   +    G+ S  + G ++  + E +      +G+  + G
Sbjct: 1304 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1353

Query: 409  TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
              ++  K++K + KS+                 KRK ++  KE    +KKAKKA  K   
Sbjct: 1354 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1390

Query: 469  EEEEEEKVAEEEETSVKKKKKRGK 492
                     + E  S KKKKK+ K
Sbjct: 1391 ---------DSESPSQKKKKKKKK 1405



 Score = 29.6 bits (65), Expect = 7.1
 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)

Query: 458  KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
            +A   K+  ++ E+E +KV +  + S +K  +  K+K      LS ++P   T    P  
Sbjct: 1235 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1284

Query: 518  KKKKK 522
            KKKKK
Sbjct: 1285 KKKKK 1289


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,410,898
Number of Sequences: 37866
Number of extensions: 841474
Number of successful extensions: 20344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 440
Number of HSP's successfully gapped in prelim test: 558
Number of HSP's that attempted gapping in prelim test: 7543
Number of HSP's gapped (non-prelim): 6449
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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