Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 7706254
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
(529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] 1032 0.0
gi|32483374 nucleolar protein 5A [Homo sapiens] 345 6e-95
gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens] 129 5e-30
gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens] 77 3e-14
gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens] 77 3e-14
gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo sap... 77 3e-14
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 53 6e-07
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 53 8e-07
gi|221219020 NYD-SP11 protein [Homo sapiens] 52 1e-06
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 51 3e-06
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 50 4e-06
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 49 1e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 1e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 48 2e-05
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 47 6e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 46 7e-05
gi|239750213 PREDICTED: hypothetical protein [Homo sapiens] 46 1e-04
gi|11225260 DNA topoisomerase I [Homo sapiens] 45 1e-04
gi|46276863 parathymosin [Homo sapiens] 45 1e-04
gi|104526627 triadin [Homo sapiens] 45 1e-04
gi|4503337 dyskerin isoform 1 [Homo sapiens] 45 2e-04
gi|215599015 dyskerin isoform 2 [Homo sapiens] 45 2e-04
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 45 2e-04
gi|4506751 restin isoform a [Homo sapiens] 45 2e-04
gi|87299628 biorientation of chromosomes in cell division 1-like... 44 3e-04
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 44 4e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 44 4e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 44 4e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 44 4e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 44 4e-04
>gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens]
Length = 529
Score = 1032 bits (2668), Expect = 0.0
Identities = 529/529 (100%), Positives = 529/529 (100%)
Query: 1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60
MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF
Sbjct: 1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60
Query: 61 TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120
TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR
Sbjct: 61 TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120
Query: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180
SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI
Sbjct: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180
Query: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240
MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI
Sbjct: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240
Query: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300
SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA
Sbjct: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300
Query: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360
HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR
Sbjct: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360
Query: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420
MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE
Sbjct: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420
Query: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480
HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE
Sbjct: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480
Query: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED
Sbjct: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
>gi|32483374 nucleolar protein 5A [Homo sapiens]
Length = 594
Score = 345 bits (885), Expect = 6e-95
Identities = 213/550 (38%), Positives = 322/550 (58%), Gaps = 32/550 (5%)
Query: 3 VLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPE----KANKIVKLKHFEKFQDTAEALA 58
VLFE +VGYA+ + K+++E+ L + E K + IV+L F F + AL
Sbjct: 6 VLFEHAVGYALLAL---KEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALE 62
Query: 59 AFTALMEGKINKQLKKVLKKIV--KEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELM 116
A+ EG +++ L+ +L+ + K+ L V D K+G I+E+L +C V+ E++
Sbjct: 63 NANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEIL 122
Query: 117 RGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKEL 176
RG+R L+ G+ LGL HS SR ++KF+ ++VD MI+Q+ISLLD LDK++
Sbjct: 123 RGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDI 182
Query: 177 NNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVE-AEVK 235
N + MR REWYG+HFPEL KII+DN TYC+ Q +G+R+ KL +L ++ A+ K
Sbjct: 183 NTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAK 242
Query: 236 A---AAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGE 292
A A+ SMG ++S D+ NI ++V+ +SEYR L+ YL+++M +AP+++ ++GE
Sbjct: 243 AILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGE 302
Query: 293 LVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSP 352
VGARLIAHAGSL NLAK+ ASTVQILGAEKALFRALK+R +TPKYGLI+H++ +G+ +
Sbjct: 303 AVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAA 362
Query: 353 KHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLR-------------TLE 399
K+KG+ISR LA K +A R D F E +S G + R ++E RL ++
Sbjct: 363 KNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMK 422
Query: 400 DRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459
+ ++ + K EK E K K + + L S + ++ +E++EK
Sbjct: 423 EAMVQAEEAAAEITRKLEKQEKKRLKK--EKKRLAALALASSENSSSTPEECEEMSEKPK 480
Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK 519
KK K K +E +E E+ S K KK KK KEE +S + T+ + + P++KK
Sbjct: 481 KKK--KQKPQEVPQENGMEDPSISFSKPKK--KKSFSKEELMSSDLEETAGSTSIPKRKK 536
Query: 520 KKKKKRENED 529
K+ D
Sbjct: 537 STPKEETVND 546
>gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens]
Length = 499
Score = 129 bits (325), Expect = 5e-30
Identities = 70/236 (29%), Positives = 129/236 (54%), Gaps = 2/236 (0%)
Query: 161 MIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDR--KNYA 218
+IV A +L +++ ELN R+ Y FPEL ++ + L Y + ++++G+ K
Sbjct: 92 VIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKN 151
Query: 219 SAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNR 278
+ L ++L V A + G ++SEE++ + C +E++ + ++YEY+++R
Sbjct: 152 NENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESR 211
Query: 279 MMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKY 338
M IAPN+++++G A+++ AG L NL+K A + +LGA++ S P
Sbjct: 212 MSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHT 271
Query: 339 GLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEAR 394
G IYH+ +V P + K +R++AAK LA R D+F E + +G E + ++E +
Sbjct: 272 GYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERK 327
>gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens]
Length = 278
Score = 77.4 bits (189), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)
Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + +
Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61
Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
+E RL E TG+ L+K +KT + T +K + ++ +
Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107
Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
E T K KK K K K +E +E ++ S K KR K KE+ +S T+
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164
Query: 511 AIASPEKKKKKKKKRENED 529
+I+ P +K K+ D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183
>gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens]
Length = 278
Score = 77.4 bits (189), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)
Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + +
Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61
Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
+E RL E TG+ L+K +KT + T +K + ++ +
Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107
Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
E T K KK K K K +E +E ++ S K KR K KE+ +S T+
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164
Query: 511 AIASPEKKKKKKKKRENED 529
+I+ P +K K+ D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183
>gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo
sapiens]
Length = 278
Score = 77.4 bits (189), Expect = 3e-14
Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%)
Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390
++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + +
Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61
Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450
+E RL E TG+ L+K +KT + T +K + ++ +
Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107
Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510
E T K KK K K K +E +E ++ S K KR K KE+ +S T+
Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164
Query: 511 AIASPEKKKKKKKKRENED 529
+I+ P +K K+ D
Sbjct: 165 SISLPNRKTSSPKEEAVND 183
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 53.1 bits (126), Expect = 6e-07
Identities = 31/97 (31%), Positives = 52/97 (53%)
Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
+ T T + + E+ K E ++K K+ + K K +E E+ K EEEE K+K+K+ K
Sbjct: 11 EETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKK 70
Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
++ +EE EEE +++KKKKKR ++
Sbjct: 71 EEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107
Score = 52.8 bits (125), Expect = 8e-07
Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 15/104 (14%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEE-----------EEEKVAEEEETSVKKKKK 489
KK++ E+ ++ +E E++ K+ K K K +E+ E EK E+EE K+K+K
Sbjct: 6 KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65
Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPE----KKKKKKKKRENED 529
R KKK +E EEE E +KKKKK++R+ E+
Sbjct: 66 RKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 19/127 (14%)
Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---------EKKAKK 461
K +TE+ E E + + +KRK ++ K+ + T EKK K+
Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64
Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
+ K K EEE EE+ EEEE +++K+ G+++ K++ +EE E++KKK
Sbjct: 65 KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEE----------EEEKKK 114
Query: 522 KKKRENE 528
K++R+ +
Sbjct: 115 KRRRKTK 121
Score = 50.4 bits (119), Expect = 4e-06
Identities = 28/72 (38%), Positives = 41/72 (56%)
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
K KK K K E EE E+ EEEE K+K+KR +K+ KE+ +E EK
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 518 KKKKKKKRENED 529
K+K+K+K++ E+
Sbjct: 61 KRKRKRKKKKEE 72
Score = 49.3 bits (116), Expect = 9e-06
Identities = 34/92 (36%), Positives = 51/92 (55%), Gaps = 14/92 (15%)
Query: 441 KKRKIEQVDKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHI 496
KK+K ++ +K E E+ K +K K K K EEEE E+ EEEE ++++K R +KK
Sbjct: 42 KKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101
Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
K EEE EKKKK+++K + +
Sbjct: 102 KRRRKEEEE----------EKKKKRRRKTKKK 123
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/74 (35%), Positives = 42/74 (56%)
Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515
+KK KK K + EE EE + EE+E K+K+K +K+ K++ E E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 516 EKKKKKKKKRENED 529
++K+K+KKK+E E+
Sbjct: 61 KRKRKRKKKKEEEE 74
Score = 38.5 bits (88), Expect = 0.015
Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 10/119 (8%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
+ + + E T E + G K K ++ E + + KT + KKRK
Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEE----------KVAEEEETSVKKKKKRGKKK 494
++ K++E ++ ++ + + K EEE+EE + EEEE KK++++ KKK
Sbjct: 65 KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 52.8 bits (125), Expect = 8e-07
Identities = 29/87 (33%), Positives = 46/87 (52%)
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
K + E+ +KE E K K + K K EEE+E K E E K +K++ +K+ +KEE
Sbjct: 349 KLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERR 408
Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528
E + + KK+++K+ RE E
Sbjct: 409 KERQEALEAKLEEKRKKEEEKRLREEE 435
Score = 37.7 bits (86), Expect = 0.026
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 6/93 (6%)
Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
GK L + E K ++K KK++ E+ KE E EK+ K K K + +
Sbjct: 345 GKQLKLRAEREEKEKLKE---EAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQ 401
Query: 470 EEEEEKVAEEE---ETSVKKKKKRGKKKHIKEE 499
+EE+ E + E +++K+K+ ++K ++EE
Sbjct: 402 RLKEERRKERQEALEAKLEEKRKKEEEKRLREE 434
Score = 30.8 bits (68), Expect = 3.2
Identities = 28/124 (22%), Positives = 63/124 (50%), Gaps = 15/124 (12%)
Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
+L+ R E +++ + K AK +K E K E+K + +KR+ ++ +
Sbjct: 347 QLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEK-ELKEKERR---------EKREKDEKE 396
Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK-----EEPLSEE 504
K ++ K+ ++ + + +E + EEK +EEE +++++KR K + + ++P + +
Sbjct: 397 KAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQ 456
Query: 505 EPCT 508
P T
Sbjct: 457 APKT 460
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 29/191 (15%)
Query: 357 KISRMLAAKTVLAIRYDAFGEDSSSAMGVENRA-----KLEARLRTLEDRGIRKISGTGK 411
K +M ++ LA ++ D G+E K R R RG +
Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215
Query: 412 ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI-----EQVDKEDEITEKKAKKAKIKV 466
+ + E EH SE +S L K+ + E+ ++E+E E++ ++ + +
Sbjct: 2216 QVDEVESEEHFSEEM------ESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHI---------KEEPLSEEEPCTSTAIASPEK 517
K EEE EEK E+EE KKKKK KK+ + KEE +SEEE T S E+
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE----TESLSDEE 2325
Query: 518 KKKKKKKRENE 528
++++ E E
Sbjct: 2326 EEEESCSLEEE 2336
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/149 (22%), Positives = 76/149 (51%), Gaps = 8/149 (5%)
Query: 379 SSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPT 438
SS VE+ + +L D ++ S + + + E+ E + E + + +
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
Query: 439 CSKKRKIEQVDKEDEITEKKAKKAKIKVKVE--EEEEEKVAEEEETSVKKKKKRGKKKHI 496
+++++E+ ++E + +K+ KK +++ K E EE+EE ++EEE S+ +++ + +
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL 2333
Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
+EE E+E I EK+ K +++R
Sbjct: 2334 EEEVDREKE------ILKKEKQFKLQEQR 2356
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/92 (28%), Positives = 51/92 (55%), Gaps = 15/92 (16%)
Query: 444 KIEQVDKEDEITEK------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
++++V+ E+ +E+ + +K + EEEE E+ E EE V+++++ K++
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275
Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
EE E+E E+KKKKKK+++ E+
Sbjct: 2276 EEKQVEKEE---------EEKKKKKKEKKKEE 2298
Score = 38.1 bits (87), Expect = 0.020
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 16/90 (17%)
Query: 450 KEDEITEKKAKKAKIKVKVEE-------------EEEEKVAEEEETSVKKKKKRGKKKHI 496
KE+E+ +++ K + K K+ E EEE K+A+EEE +++K+K +
Sbjct: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH--- 1787
Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
KE+ EEE EKK K +KRE
Sbjct: 1788 KEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817
Score = 35.4 bits (80), Expect = 0.13
Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 24/141 (17%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
E + E +R E+ + G K + K E+ + K + K++K
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK----------------KEKKK 2296
Query: 446 EQVDKEDEITEKK----AKKAKIKVKVEEEEEEKVAEEEETS----VKKKKKRGKKKHIK 497
E+V +++E+ E+K +++ + EEEEEE + EEE + KK+K+ K + +
Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356
Query: 498 EEPLSEEEPCTSTAIASPEKK 518
+ L E S P K
Sbjct: 2357 RKSLRGRERVLSILRGVPHGK 2377
Score = 34.3 bits (77), Expect = 0.29
Identities = 22/70 (31%), Positives = 42/70 (60%), Gaps = 4/70 (5%)
Query: 440 SKKRKIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETS-VKKKKKRGKKKHI 496
S K K +Q E+E+T E+ +++ + K + EE+ + EE + + + +K+ R +KK
Sbjct: 1530 SSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589
Query: 497 KEE-PLSEEE 505
+EE L++EE
Sbjct: 1590 QEERKLAQEE 1599
Score = 34.3 bits (77), Expect = 0.29
Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 4/122 (3%)
Query: 382 AMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
A + RA+ E +L E+ K++ + LA+ E+ ++ VK +
Sbjct: 1582 ARAEKKRAQEERKLAQEEE----KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
+K E + + E ++A+K K K ++ EKVA EEE KK K + K+I + +
Sbjct: 1638 AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKV 1697
Query: 502 SE 503
E
Sbjct: 1698 EE 1699
Score = 33.5 bits (75), Expect = 0.49
Identities = 29/118 (24%), Positives = 58/118 (49%), Gaps = 29/118 (24%)
Query: 441 KKRKI-----EQVDKEDEITEKKAKKAK--IKVKVEEEEEEKVAEEE-------ETSVKK 486
K+RK+ ++KE+++TE+++K A+ +V +++EEE + EEE +K
Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201
Query: 487 KKKRGKK---------------KHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
+ KRG K +H EE S + S E++++++++ E E+
Sbjct: 2202 EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREE 2259
Score = 32.0 bits (71), Expect = 1.4
Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 25/138 (18%)
Query: 414 AKTEKYEHKSEVKTYDPSG----DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
+K ++Y+ + EV + + ++R I++ K I K+A+ K + + E
Sbjct: 1533 SKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE 1592
Query: 470 E---EEEEKVAEEEETSVKKKKKRGK-----------------KKHIKEEPLSEE-EPCT 508
+EEEK+A+EE ++++K + K KEE L++ E +
Sbjct: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLS 1652
Query: 509 STAIASPEKKKKKKKKRE 526
A +K+KK KK E
Sbjct: 1653 QEAEKLAQKRKKLAKKWE 1670
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 6/129 (4%)
Query: 401 RGIRKISGTGKALAKTE----KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITE 456
RG++K TE + E +E + S S + ++ K+ + E
Sbjct: 1098 RGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQE 1157
Query: 457 KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPE 516
K K I + ++ ++ + +++ + +K KK+ KKK + + ++EE T + P
Sbjct: 1158 KDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEE--TTPPVMEQPV 1215
Query: 517 KKKKKKKKR 525
KK K + R
Sbjct: 1216 TKKVKIQGR 1224
Score = 31.6 bits (70), Expect = 1.9
Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 16/95 (16%)
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVK------VEEEEEEKVAEEEETSVKKKKK--RGKK 493
+RK + ++ +T K + ++K K + + EEK+ +E+ET +KKK+K +K
Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914
Query: 494 KHI--------KEEPLSEEEPCTSTAIASPEKKKK 520
K + K+E L++E+ + A + KK+
Sbjct: 1915 KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949
Score = 29.3 bits (64), Expect = 9.3
Identities = 24/109 (22%), Positives = 49/109 (44%), Gaps = 11/109 (10%)
Query: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKV 476
H+ + ++ K+ Q +++ E+K +A +K+ ++ E E K
Sbjct: 1578 HRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637
Query: 477 AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS---TAIASPEKKKKKK 522
A++EET +RG+K + E L+++ + +A E+K KK
Sbjct: 1638 AQKEETLA----QRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 50.8 bits (120), Expect = 3e-06
Identities = 47/204 (23%), Positives = 88/204 (43%), Gaps = 7/204 (3%)
Query: 330 KSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKT-----VLAIRYDAFGEDSSSAMG 384
+S+ +TP+ + H + K K + + KT V + E S
Sbjct: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAE 619
Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444
V + + + + +++ ++K + K EK + K EV + KK +
Sbjct: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679
Query: 445 IE-QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE 503
++ +V KE + EKK K ++K + +E +K ++EE KK+++ KK IK+ P
Sbjct: 680 VKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDA 739
Query: 504 EEPCTSTAIA-SPEKKKKKKKKRE 526
++ T + A P K K K+E
Sbjct: 740 KKSSTPLSEAKKPAALKPKVPKKE 763
Score = 48.9 bits (115), Expect = 1e-05
Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 438 TCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
T K+ K++ DK++E + K + AK + K ++EEK +EE VKK+ K+ KK K
Sbjct: 637 TVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE---VKKEVKKEIKKEEK 693
Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
+EP E + T E KK++KK+ + E+
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/142 (27%), Positives = 70/142 (49%), Gaps = 20/142 (14%)
Query: 405 KISGTGKALAKTEK---YEHKSEVKTYD-PSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460
K+ K + K +K E K V + PS + P ++ + + D + + ++K
Sbjct: 579 KVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV 638
Query: 461 KAKIKVKVEEEEEEK-------VAEEEETSVKKKKKRGK-------KKHIKEEPLSEEEP 506
K + KVK E+++EEK +E++T +KK++K K KK IK+E ++EP
Sbjct: 639 KKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE--EKKEP 696
Query: 507 CTSTAIASPEKKKKKKKKRENE 528
+P K+ KK+ K+E +
Sbjct: 697 KKEVKKETPPKEVKKEVKKEEK 718
Score = 39.7 bits (91), Expect = 0.007
Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
K +K E K EVK K+ K E+ + + +K+ ++K +V++EE++
Sbjct: 674 KPKKEEVKKEVK--------------KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKK 719
Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523
+V +EE+ K+ KK K PLSE + + P+K++ KK
Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768
Score = 38.5 bits (88), Expect = 0.015
Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 22/112 (19%)
Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK--------- 461
K + K EK E K EVK P + KK + ++V KE++ +K+ KK
Sbjct: 686 KEIKKEEKKEPKKEVKKETPPKEVKKEV--KKEEKKEVKKEEKEPKKEIKKLPKDAKKSS 743
Query: 462 ---------AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504
A +K KV ++EE +++ + K K++GK K IK+E + E
Sbjct: 744 TPLSEAKKPAALKPKVPKKEES--VKKDSVAAGKPKEKGKIKVIKKEGKAAE 793
Score = 31.2 bits (69), Expect = 2.5
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 445 IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS-- 502
+ VD E E+ KA K E+ + +K + ++S KK GK K + P
Sbjct: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAG 2276
Query: 503 -EEEPCTSTAIASPEKKKKKKK 523
+E + +ASP+KK+ +K
Sbjct: 2277 LKESSDKVSRVASPKKKESVEK 2298
>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
Length = 1316
Score = 50.4 bits (119), Expect = 4e-06
Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 10/92 (10%)
Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
S+KR+ + V+ D EKKA++++ K +EE + +K + KKKK+ K KH +
Sbjct: 1159 SRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKS------KKKKKSKDKHRDRD 1212
Query: 500 PLSEEEPCTSTAIASPE----KKKKKKKKREN 527
+++ S A + + KKKKKKKKR +
Sbjct: 1213 SRHQQDSDLSAACSDADLHRHKKKKKKKKRHS 1244
Score = 29.3 bits (64), Expect = 9.3
Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 7/52 (13%)
Query: 478 EEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
E ++ V+KK +R ++K EEP +++ +KKKK K K + D
Sbjct: 1168 ENSDSHVEKKARRSEQKDPLEEPKAKKHK-------KSKKKKKSKDKHRDRD 1212
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 48.5 bits (114), Expect = 1e-05
Identities = 50/192 (26%), Positives = 90/192 (46%), Gaps = 24/192 (12%)
Query: 349 QTSPKHKGK------ISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLE-DR 401
+T KHK K IS+ L K+ Y+ + S A+ +EN E +L+ L+ DR
Sbjct: 633 KTKHKHKNKEKGQCSISQELKLKS-FTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDR 691
Query: 402 G-IRKISGTGKALAKTEKY---EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457
+K K + +++ + KS + D + D + +K + + +KE + EK
Sbjct: 692 DHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEK 751
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
K+ K+++ EE +++ S + K KK +KE+ +S+E+ I +K
Sbjct: 752 SPKEEKLRLYKEERKKK--------SKDRPSKLEKKNDLKEDKISKEKE----KIFKEDK 799
Query: 518 KKKKKKKRENED 529
+K KK+K ED
Sbjct: 800 EKLKKEKVYRED 811
Score = 38.9 bits (89), Expect = 0.012
Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 12/94 (12%)
Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK-------KAKKAK 463
K K E+Y+ KS K D S S L C K ++ ++ KE + T++ K K+ K
Sbjct: 1020 KEKTKPERYKEKSSDK--DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK 1077
Query: 464 IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKK 494
+ +E++EK E+ S KK K+GK+K
Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK 1111
Score = 35.8 bits (81), Expect = 0.099
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 11/113 (9%)
Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
AK EK E K + + Y G ++ Q +K+ + +K +E+E +
Sbjct: 1366 AKKEKAEKKEKGEDYKEGGS--------RKDSGQYEKDFLEADAYGVSYNMKADIEDELD 1417
Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
+ + E S +KK K ++ ++ E +P S+AI ++KKK++K RE
Sbjct: 1418 KTI---ELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHRE 1467
Score = 33.9 bits (76), Expect = 0.38
Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%)
Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCT 508
D++D + + K K K+ E+ E+K A E++ K K+K K+H KE S
Sbjct: 1219 DRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEK-SDKEHSKERKSSRSADAE 1277
Query: 509 STAIASPEKKKKKKKKRENED 529
+ + E++ + + ++ D
Sbjct: 1278 KSLLEKLEEEALHEYREDSND 1298
Score = 30.4 bits (67), Expect = 4.2
Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 449 DKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHIKEEPLSEE 504
DK++++ EK K KK K + ++ +++ + + K K+K + +KKH E+ +
Sbjct: 1196 DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK 1255
Query: 505 EPCTSTAIASPEKKKKKKKKRE 526
S S E+K + E
Sbjct: 1256 HKEKSDKEHSKERKSSRSADAE 1277
Score = 30.4 bits (67), Expect = 4.2
Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 32/142 (22%)
Query: 416 TEKYEHKSEVKTYDPSGDST----LPTCSKKRKI----------EQVDKEDEITEKKAKK 461
TEKY+ + + + D + D LP ++K+ E+ DKE K ++
Sbjct: 1214 TEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRS 1273
Query: 462 AKI-KVKVEEEEEEKVAEEEETSVKKKKK--------RGKKKHIK-------EEPLSEEE 505
A K +E+ EEE + E E S K + RG++ + EP +++
Sbjct: 1274 ADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDK 1333
Query: 506 PCTSTAIASPEKKKKKKKKREN 527
P S + PEK K+K++ R +
Sbjct: 1334 PRESACL--PEKLKEKERHRHS 1353
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 48.5 bits (114), Expect = 1e-05
Identities = 40/144 (27%), Positives = 73/144 (50%), Gaps = 7/144 (4%)
Query: 384 GVENRAKLEARLRTLEDRGIR-KIS-GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
G ++++K + R E+ ++ K++ TG A EK E + + D GD K
Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED-DNEGDKK----KK 316
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
+K ++ +KE++ EKK +K VK +E K+ EEEE +++++R K+ E
Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376
Query: 502 SEEEPCTSTAIASPEKKKKKKKKR 525
EEE ++K+K++K+R
Sbjct: 377 KEEERLEQEKRERKKQKEKERKER 400
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 41/180 (22%)
Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR------ 443
KL + + + +K G+ + ++K + +S + + SGD + ++
Sbjct: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ 204
Query: 444 ------KIEQVDKEDE-------ITEKKAKKAKIKVKVEEEEE---EKVAEEEETSVKKK 487
IE +++D+ + +KKA+K + + K +EE+ K+ E+EE KK
Sbjct: 205 KNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264
Query: 488 ---KKRGKKKHIKEE-------------PLSEEEPCTSTAIASP---EKKKKKKKKRENE 528
K++ ++ +EE P SEE+ T TA +KKKK KKK++ E
Sbjct: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE 324
Score = 41.2 bits (95), Expect = 0.002
Identities = 37/147 (25%), Positives = 71/147 (48%), Gaps = 6/147 (4%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSE---VKTYDPSGDSTLPTCSKK 442
+ R + +A+LR L+++ ++ K +K ++ + K E VK+ +P +K
Sbjct: 241 KKRDEEKAKLRKLKEK--EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298
Query: 443 RKIEQVDKEDEITEKKAK-KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501
+ ++D +KK K K K K + EE+E+EK + +VK ++ K +EE
Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358
Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528
EE + E K+K++++ E E
Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQE 385
Score = 40.8 bits (94), Expect = 0.003
Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 23/161 (14%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
+D+S + + K E + R + R K AK K + K E++T
Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEK--------AKLRKLKEKEELETGKKDQ---- 266
Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
SK+++ ++ +E+ + K + EE+ E A E++ KKKK KKK
Sbjct: 267 ---SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323
Query: 497 KEEPLSEEE---PCTSTAIASPE-----KKKKKKKKRENED 529
++E +E+ P +T A E K++++++KRE E+
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364
Score = 40.4 bits (93), Expect = 0.004
Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 22/170 (12%)
Query: 382 AMGVENRAK--LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD---PSGDSTL 436
A GVE +K L + ED+ +KI ++ +E E + V+ + P + T
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487
Query: 437 PTCSKKRKIEQVDK---------EDEITEK-KAKKAKIKVKV-------EEEEEEKVAEE 479
P + + + D DE TEK + K I+VK EEEEEE+ E
Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547
Query: 480 EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
EE ++ + G + ++E +S+E+ T P K+ + +++D
Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597
Score = 36.2 bits (82), Expect = 0.076
Identities = 25/96 (26%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 408 GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIK-- 465
G K K +K K E + G S + + + ++ KE+E +K+ ++ +IK
Sbjct: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL-KEEEERQKREEEERIKRL 369
Query: 466 --VKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
++ + +EEE++ E+E+ KK+K++ +K+ +K+E
Sbjct: 370 EELEAKRKEEERL-EQEKRERKKQKEKERKERLKKE 404
Score = 33.5 bits (75), Expect = 0.49
Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 11/116 (9%)
Query: 422 KSEVKTYDPSGD----STLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA 477
K +V+ Y S D + LP +K + + K D E + KIK + +
Sbjct: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG 187
Query: 478 EEEETSVKKKKKRGKKKHIKEEP-----LSEEEPCTSTAIASPEKKKKKKKKRENE 528
+E + ++ +K G+KK+ K +P E+ S I + +KK +KK+RE +
Sbjct: 188 DESDEFLQSRK--GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241
Score = 33.5 bits (75), Expect = 0.49
Identities = 17/82 (20%), Positives = 45/82 (54%)
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
E+ ++++E E++ ++ + + +EE+EKV++E+++ KK K+ E S+++
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598
Query: 506 PCTSTAIASPEKKKKKKKKREN 527
K++ +K++ E+
Sbjct: 599 RTKEERAYDKAKRRIEKRRLEH 620
Score = 31.2 bits (69), Expect = 2.5
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 14/100 (14%)
Query: 441 KKRKIEQVDKEDEITEK-----------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK 489
KK K +Q ED+I ++ KA + + VK E EE+ +++ KKK +
Sbjct: 45 KKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDK---KKKGQ 101
Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
+GKK+ + E E S + + + K + +++D
Sbjct: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 48.1 bits (113), Expect = 2e-05
Identities = 37/147 (25%), Positives = 61/147 (41%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
E++ S ++ K EA+ +++ + T + K E KS K P TL
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759
Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
S + K ++ +K +KAK VK E + EK + K +K KK
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819
Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKK 523
+ P+ EEE + P KK +++K
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEK 846
Score = 42.7 bits (99), Expect = 8e-04
Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 20/109 (18%)
Query: 430 PSGDSTLPTCS---------KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE- 479
P G +P+ S K + +E+ +KE I E++ ++ ++ +V EEEE++ EE
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEE 482
Query: 480 --EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
EE ++++ G ++ K P E ASPEK+ K K E
Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEE--------AASPEKEAKSPVKEE 523
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 6/140 (4%)
Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
K A +T E + +K K K + E K +P+ + + + +K E D
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK------EPAVEKPKESKVEAKKEEAED 899
Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509
K+ T +K AK++VK + + +EK ++ K K K K+E E++
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
Query: 510 TAIASPEKKKKKKKKRENED 529
PE+K K + K + +D
Sbjct: 960 EKAKKPEEKPKTEAKAKEDD 979
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 2/147 (1%)
Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444
V++ K E + + ++ + K + KA A + E K K P ++ P +K++
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879
Query: 445 IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA--EEEETSVKKKKKRGKKKHIKEEPLS 502
++ E K ++A+ K KV E+E A E +E + K+K KK +
Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939
Query: 503 EEEPCTSTAIASPEKKKKKKKKRENED 529
E A+PEKK K++K + +
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPE 966
Score = 40.0 bits (92), Expect = 0.005
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 7/107 (6%)
Query: 418 KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEE---EEE 474
K + + ++K + S T+ + + E+ +E+TE++ K+AK + EEE EEE
Sbjct: 437 KVKSEEKIKVVEKSEKETVIV---EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEE 493
Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
EEET ++ + + P+ EE + A SPEK++ K
Sbjct: 494 AEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA-KSPEKEEAK 539
Score = 39.7 bits (91), Expect = 0.007
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV-KVEEEEEEKVAE 478
E K E K + +PT K+ + KED ++K + AK + + +E K AE
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 479 EEETSVKKK-KKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
++E + +KK K K K +E+P +E + S E K K +K E
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
Score = 38.1 bits (87), Expect = 0.020
Identities = 36/152 (23%), Positives = 68/152 (44%), Gaps = 13/152 (8%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGK-ALAKTE-----KYEHKSEVKTYDP 430
E A+ +K+EA+ ED+ +K+ K A AK E K + K+EV +P
Sbjct: 876 EKKEPAVEKPKESKVEAKKEEAEDK--KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933
Query: 431 SGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKR 490
K E ++ + E+KAKK + K K E + A+E++ ++ K+ +
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-----AKEDDKTLSKEPSK 988
Query: 491 GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
K + ++ ++++ A+ +K K K
Sbjct: 989 PKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 37.4 bits (85), Expect = 0.034
Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 10/116 (8%)
Query: 418 KYEHKSEVKTYDP-SGDSTLPT--CSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
K E KS K P D+ P KK +++ KE+E K ++ K+K ++ EEE
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE----KPQEVKVKEPPKKAEEE 845
Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK--KKKKKRENE 528
K +T KK K+ + KE P + E A+ P++ K KK++ E++
Sbjct: 846 KAPATPKTEEKKDSKKEEAPK-KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Score = 35.8 bits (81), Expect = 0.099
Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 9/127 (7%)
Query: 411 KALAKTEKYEHKSEVKTYD---PSGDSTLPTCSKKRKIEQVDKEDEITEKK-----AKKA 462
K AK E+ E K +V T + P+ K K E KE + + K A+K
Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948
Query: 463 KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
+ + ++ +EEK + EE + K + K + +EP S+ + + +S ++K K
Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP-SKPKAEKAEKSSSTDQKDSKP 1007
Query: 523 KKRENED 529
++ ED
Sbjct: 1008 PEKATED 1014
Score = 33.9 bits (76), Expect = 0.38
Identities = 42/163 (25%), Positives = 64/163 (39%), Gaps = 20/163 (12%)
Query: 376 GEDSSSAMGVENRAKL----EARLRTLEDRGIRKISGTGKALAKT-EKYEHKSEVKTYDP 430
G + A G E K EA E + K A AK+ EK E KS + P
Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547
Query: 431 SG-------DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETS 483
++ P +K + E+ E+ + K+ K + + E K E+ ++
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Query: 484 VKKKKKRGK--KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
VK++ K K +KEE S E + SPEK K K+
Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAE------VKSPEKAKSPTKE 644
Score = 33.9 bits (76), Expect = 0.38
Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 14/153 (9%)
Query: 385 VENRAKLEARLRTLED-RGIRKISGTGKALAKT-EKYEHKSEVKTYDP-SGDSTLPTCSK 441
V+ AK A +++ E + K AK+ EK E KS K P ++ P +K
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 442 ---KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKH--I 496
K + + +K +++AK + K K +EE K E+ ++ VK++ K +K +
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPE-KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740
Query: 497 KEEPLSEE-----EPCTSTAIASPEKKKKKKKK 524
KEE S E E + + SPE K K++
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Score = 32.0 bits (71), Expect = 1.4
Identities = 35/156 (22%), Positives = 63/156 (40%), Gaps = 27/156 (17%)
Query: 373 DAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSG 432
D F E + S + E ++ +A+ ED A A ++ K EVK+
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKED-----------AKAPEKEIPKKEEVKS----- 822
Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
++ K ++V ++ + + +KA K EE+++ K E + K K K
Sbjct: 823 -----PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Query: 493 KKHIKEEP------LSEEEPCTSTAIASPEKKKKKK 522
K+ E+P +EE + +PEK+ K
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Score = 31.6 bits (70), Expect = 1.9
Identities = 38/147 (25%), Positives = 53/147 (36%), Gaps = 21/147 (14%)
Query: 399 EDRGIRKISGTGKALAKTE---KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT 455
E + K KA AK+ K K+E K+ + + K + KE+ +
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 456 EKKAK-----------KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504
+KAK KAK VK E + EK E+ K K KEE S
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778
Query: 505 EPCTSTA-------IASPEKKKKKKKK 524
+ A + SPEK K K+
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKE 805
Score = 31.2 bits (69), Expect = 2.5
Identities = 28/121 (23%), Positives = 49/121 (40%), Gaps = 9/121 (7%)
Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK-----KAKIKVK 467
+ + E+ E K E + G+ ++ +E EK+AK +AK +
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529
Query: 468 VEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE----EEPCTSTAIASPEKKKKKKK 523
+ E+E+ E +K K K+ K P ++ EE + + SPEK K K
Sbjct: 530 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589
Query: 524 K 524
+
Sbjct: 590 E 590
Score = 30.8 bits (68), Expect = 3.2
Identities = 34/151 (22%), Positives = 58/151 (38%), Gaps = 9/151 (5%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
E++ S ++ K EA+ E + K K AK+ E + +
Sbjct: 522 EEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK--VAEEEETSVKKKKKRGKKK 494
P +K E+ E + K+ +K + + E K V EE ++ + K K
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640
Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
KEE S E+ SPEK++ K ++
Sbjct: 641 PTKEEAKSPEKA------KSPEKEEAKSPEK 665
Score = 29.3 bits (64), Expect = 9.3
Identities = 27/151 (17%), Positives = 63/151 (41%), Gaps = 8/151 (5%)
Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR 443
G+ + ++ + I+ + + K E+ +++V T + + + ++
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEG 483
Query: 444 KIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK---- 497
K E+ +E+E E++ K + E+E K +EE + K +K+ K
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 498 -EEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
+ P + P A + PE K +K++ ++
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 46.6 bits (109), Expect = 6e-05
Identities = 36/141 (25%), Positives = 66/141 (46%), Gaps = 21/141 (14%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
E K + + + ++RG G + + K E + E ++RK
Sbjct: 108 EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE----------------RERKK 151
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
E+ +KE E E+K ++ K +V E+EEE+ +E+E +KK++R +K+ KE E
Sbjct: 152 EEREKERERKERKKRERK---QVGEKEEER--KEKERKERKKRERNRKERKKERERKERR 206
Query: 506 PCTSTAIASPEKKKKKKKKRE 526
E+KK+++K R+
Sbjct: 207 ERKKERKKKEERKKERQKDRQ 227
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/144 (23%), Positives = 68/144 (47%), Gaps = 3/144 (2%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
E + + + R + R K + G+ K +K E K +T S + ++RK
Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT---SKEGKERERKEERKR 141
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
E+ + + E++ K+ + K + + E ++ +EEE K++K+R K++ ++E E E
Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Query: 506 PCTSTAIASPEKKKKKKKKRENED 529
KKK+++KK +D
Sbjct: 202 RKERRERKKERKKKEERKKERQKD 225
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 9/121 (7%)
Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474
K K E +SE K + K+RK E+ KE + KK ++ + K + E+E +E
Sbjct: 49 KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108
Query: 475 KVAEEEETSVKKKKKR-------GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
EE+E KK+KK GK++ KEE EE EK++++K++++
Sbjct: 109 --GEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166
Query: 528 E 528
E
Sbjct: 167 E 167
Score = 39.3 bits (90), Expect = 0.009
Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 12/90 (13%)
Query: 441 KKRKIE---QVDKEDEITEKKAKKAKIKVKVEEEEEEKV--AEEEETSVKKKKKRGKKKH 495
++R+IE + KE E KK ++ + K K E E+E K ++E+ +KK++R +KK
Sbjct: 41 REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100
Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
+E+ E E ++KKK+KK+R
Sbjct: 101 RREKENKEGEE-------KEKRKKKEKKER 123
Score = 37.4 bits (85), Expect = 0.034
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 4/85 (4%)
Query: 444 KIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK----KKKKRGKKKHIKEE 499
+I + ++E E ++ K+ + + K E E EK E E K KK+K+G++K + E
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
+ EK+KKK+KK
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKK 121
Score = 36.6 bits (83), Expect = 0.058
Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 3/83 (3%)
Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK---HIKEEPLSEEE 505
++E EI +K K + + + ++E E+ + E ++K++RGKK+ K+E ++
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 506 PCTSTAIASPEKKKKKKKKRENE 528
E+K+K+KKK + E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKE 122
Score = 34.3 bits (77), Expect = 0.29
Identities = 18/75 (24%), Positives = 44/75 (58%), Gaps = 4/75 (5%)
Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514
+E + ++ +I+ + E ++E + ++E ++K+KR ++K K E +E+
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK----KGERK 91
Query: 515 PEKKKKKKKKRENED 529
E++++KK++RE E+
Sbjct: 92 KEERERKKRRREKEN 106
Score = 29.3 bits (64), Expect = 9.3
Identities = 24/105 (22%), Positives = 47/105 (44%)
Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447
R + + R R E+R + K + + E + E K + K+RK E+
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
KE +K+ KK + + K +++ + E+E +++K+R K
Sbjct: 201 ERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 46.2 bits (108), Expect = 7e-05
Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 16/162 (9%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
E+ A R K E + R E+R ++I K A+ E+ K E K
Sbjct: 319 EEEKRAAEERQRIKEEEK-RAAEER--QRIKEEEKRAAE-ERQRIKEEEKRAAEERQRAR 374
Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE--------EKVAEEEETSVKKKK 488
+K K+E+ + ++ EKK + K+K E+ E+ EK A+E++ K
Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
Query: 489 KRGKKK----HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
K+G++K K E L E++P EK KK K+ +E
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476
Score = 40.8 bits (94), Expect = 0.003
Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 4/116 (3%)
Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEE 470
K+ ++ E+YE + E +T S +++ K E +KE+E EK + + + +VE
Sbjct: 152 KSESRQERYEIE-ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEV 210
Query: 471 EEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE-PCTSTAIASPEKKKKKKKKR 525
EEK E +E +V K G+ EEP EEE S I+ EK +++ K+R
Sbjct: 211 MVEEKTTESQEETVVMSLKNGQIS--SEEPKQEEEREQGSDEISHHEKMEEEDKER 264
Score = 40.0 bits (92), Expect = 0.005
Identities = 28/146 (19%), Positives = 64/146 (43%), Gaps = 11/146 (7%)
Query: 383 MGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKK 442
M E++ + EA LE +I E+ ++E K +++
Sbjct: 257 MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA-----------AAQE 305
Query: 443 RKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS 502
R+ + ++ + + E++ + A+ + +++EEE+ E + ++K+ +++ IKEE
Sbjct: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528
E EK K +++KR +
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQ 391
Score = 37.7 bits (86), Expect = 0.026
Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 10/155 (6%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436
E+ A R K E + R E+R + KA + +K + E K + +
Sbjct: 347 EEEKRAAEERQRIKEEEK-RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH-----AMQ 400
Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIK---VKVEEEEEEKVAEEEETSVKKKKKRGKK 493
T K K+EQ + + EKKA++ K++ +K + EE+ + + +++ K KK
Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460
Query: 494 KHIKEEPL-SEEEPCTSTAIASPEKKKKKKKKREN 527
+ IK+E + ++EP KK + K +N
Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495
Score = 35.8 bits (81), Expect = 0.099
Identities = 20/90 (22%), Positives = 46/90 (51%)
Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
S K+E+ DKE E+ +A+ + +++ E+++K+A+E ++K +++ +E
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311
Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENED 529
E A ++ K+++KR E+
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEE 341
Score = 35.0 bits (79), Expect = 0.17
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 426 KTYDPS-GDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV 484
K +DP+ D++L S R+++ E+E TEK+ K + + E EE E V + + +
Sbjct: 119 KEFDPTITDASLSLPS--RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176
Query: 485 KKKKKRGKKKHIKEEPLSEEEP 506
+ + KK+ ++E EE+P
Sbjct: 177 WRDAEENKKEDKEKEEEEEEKP 198
Score = 33.9 bits (76), Expect = 0.38
Identities = 33/165 (20%), Positives = 77/165 (46%), Gaps = 21/165 (12%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKTYDPSGDSTLPTCSKKR 443
+ RA++EA + R+ + + + + EK E + +K + ++
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 444 KI-----EQVDKEDEITEKKAKKAKI----KVKVEEEEEEKVAEEEETSVKKKKKRGKK- 493
K +++ +E++ ++ ++A+ K KVEE++ K EE++ ++++ K +G+K
Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409
Query: 494 ------KHIKEEPLSEEEPCTSTAIASPEKKKKK---KKKRENED 529
K + E+ E++ T+ E+K K K+++ ED
Sbjct: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454
Score = 33.1 bits (74), Expect = 0.64
Identities = 24/92 (26%), Positives = 49/92 (53%), Gaps = 4/92 (4%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKV---KVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
++R+ E +E E ++K ++A +++ K + EE KV EEEE +K+++ +K +
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR-RKQEEADRKLREE 598
Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
EE +E + EK++K + ++D
Sbjct: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 630
Score = 32.3 bits (72), Expect = 1.1
Identities = 25/114 (21%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 416 TEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK 475
T K +H +E P G +++ T + QV+ + E + ++ + E EE EK
Sbjct: 500 THKLKH-TENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGE----TESEEFEK 553
Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
+ ++++ + + ++ KK+ + + L EEE A + +++++K+R E+
Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607
Score = 31.2 bits (69), Expect = 2.5
Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 393 ARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDST------LPTCSKKRKIE 446
A + T E G ++ GK L + + ++E + ++ L KKR+
Sbjct: 517 ASVDTKEAEGAPQVEA-GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
+ E+E +K ++A K++ EEEEK +EE ++ + K++ + E+ LS+++
Sbjct: 576 RKVLEEEEQRRKQEEADRKLR---EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Score = 29.6 bits (65), Expect = 7.1
Identities = 22/111 (19%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV----KVEEEEEEK 475
E++ EV + + +S T K Q+ E+ E++ ++ ++ K+EEE++E+
Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKER 264
Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
E ++++R K + K+ A+ E+++++ ++RE
Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315
>gi|239750213 PREDICTED: hypothetical protein [Homo sapiens]
Length = 248
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/86 (29%), Positives = 46/86 (53%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
+K+K + K+ + T KK KK K K + +++ ++T+ K++ K+K ++E
Sbjct: 27 RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86
Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526
E+E +KKKKKKKK++
Sbjct: 87 EKEKEKEKEKEKKKKKKKKKKKKKKK 112
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/80 (32%), Positives = 42/80 (52%)
Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476
+K + K+ +K + T K++ K T K+ +K K K K +E+E+EK
Sbjct: 34 KKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKE 93
Query: 477 AEEEETSVKKKKKRGKKKHI 496
E+E+ KKKKK+ KKK +
Sbjct: 94 KEKEKKKKKKKKKKKKKKKL 113
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 1/88 (1%)
Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469
G+ T+K + K + T +K +K K+ T K K+ K K K +
Sbjct: 26 GRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE-KEKEKEK 84
Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIK 497
E+E+EK E+E+ KKKKK+ KKK K
Sbjct: 85 EKEKEKEKEKEKEKKKKKKKKKKKKKKK 112
Score = 41.2 bits (95), Expect = 0.002
Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476
EK +E ++ G T KK+K + K+ + T KK K K + ++
Sbjct: 11 EKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTT 70
Query: 477 AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527
+E +K+K++ K+K ++E E++ +KKKKKKKK+ N
Sbjct: 71 TTTKEKEKEKEKEKEKEKEKEKEKEKEKK-------KKKKKKKKKKKKKLN 114
Score = 39.3 bits (90), Expect = 0.009
Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 1/71 (1%)
Query: 438 TCSKKRKIEQVDKEDEITEKKAKKA-KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
T +KK+ + K T+K K K K +E+E+EK E+E+ K+KKK+ KKK
Sbjct: 48 TTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKEKEKEKKKKKKKKKK 107
Query: 497 KEEPLSEEEPC 507
K++ + C
Sbjct: 108 KKKKKLNAKVC 118
Score = 37.7 bits (86), Expect = 0.026
Identities = 25/90 (27%), Positives = 42/90 (46%)
Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAK 463
RK T K K + K + T + T + +K +++ EK+ +K K
Sbjct: 27 RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86
Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKK 493
K K +E+E+EK ++++ KKKKK K
Sbjct: 87 EKEKEKEKEKEKKKKKKKKKKKKKKKLNAK 116
Score = 36.2 bits (82), Expect = 0.076
Identities = 25/86 (29%), Positives = 48/86 (55%), Gaps = 9/86 (10%)
Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI-----KEEPLS 502
++K ITEK++ + + K ++++K ++T++KKKKK KK K +
Sbjct: 10 MEKVHVITEKESAWKRGRKKKTTKKKKK----KKTTMKKKKKTTTKKKTTTKTKKRTTTT 65
Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528
++ T+T EK+K+K+K++E E
Sbjct: 66 KKTTTTTTKEKEKEKEKEKEKEKEKE 91
Score = 35.4 bits (80), Expect = 0.13
Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 12/85 (14%)
Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE----------- 504
+K K+ V E+E K +++T+ KKKKK+ K K+ ++
Sbjct: 5 DKGVAMEKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTT 64
Query: 505 -EPCTSTAIASPEKKKKKKKKRENE 528
+ T+T EK+K+K+K++E E
Sbjct: 65 TKKTTTTTTKEKEKEKEKEKEKEKE 89
Score = 33.5 bits (75), Expect = 0.49
Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 2/93 (2%)
Query: 401 RGIRKISGTGKALAKTE-KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459
RG +K + K KT K + K+ K + T +KK ++++ EK+
Sbjct: 25 RGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEK 84
Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
+K K K K E+E+E+K ++++ KKKK K
Sbjct: 85 EKEKEKEK-EKEKEKKKKKKKKKKKKKKKLNAK 116
Score = 30.4 bits (67), Expect = 4.2
Identities = 18/74 (24%), Positives = 37/74 (50%), Gaps = 8/74 (10%)
Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515
+KK K K K K ++++K +++T+ K KK+ K E+E
Sbjct: 28 KKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE--------KE 79
Query: 516 EKKKKKKKKRENED 529
++K+K+K+K + ++
Sbjct: 80 KEKEKEKEKEKEKE 93
>gi|11225260 DNA topoisomerase I [Homo sapiens]
Length = 765
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/148 (25%), Positives = 66/148 (44%), Gaps = 21/148 (14%)
Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEK---YEHKSEVKTYDPSGDSTLPTCS 440
G + K + + R E R K+ +G A K EK + ++K +P D
Sbjct: 72 GSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKD-EPEDDGYFVPPK 130
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
+ K + ++++ + K KK K + ++E++ K+ EEE+ +KK K + K K + E
Sbjct: 131 EDIKPLKRPRDEDDADYKPKKIKTE-DTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPE-- 187
Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528
P+ KKKK KK E +
Sbjct: 188 --------------PDNKKKKPKKEEEQ 201
Score = 37.7 bits (86), Expect = 0.026
Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 10/120 (8%)
Query: 415 KTEKYEHKSEVKTYDPS----GDSTLPTCSKKRKIEQVDK-EDEITEKKAKKAKIKVKVE 469
K ++ HK K D +S KK K ++ K +D +EK K K + K E
Sbjct: 29 KDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDK-E 87
Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529
+ +EEKV + +KK+K+ G P ++EP P++ K K+ +ED
Sbjct: 88 KRKEEKVRASGDAKIKKEKENG----FSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDED 143
Score = 30.0 bits (66), Expect = 5.5
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKVAEEEETSVKKKKKRGKKKH 495
S K K + D+E E K +K + K K E E+K E+E+T K K +K
Sbjct: 21 SHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKT--KHKDGSSEKHK 78
Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
K + +E+ AS + K KK+K+
Sbjct: 79 DKHKDRDKEKRKEEKVRASGDAKIKKEKE 107
Score = 29.6 bits (65), Expect = 7.1
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 9/84 (10%)
Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV--KKKKKRGKKKHIKEEPLSEE 504
Q++ + + + K K K + +E K ++ E S + K +KKH ++E +
Sbjct: 11 QIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHK 70
Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528
+ S EK K K K R+ E
Sbjct: 71 D-------GSSEKHKDKHKDRDKE 87
>gi|46276863 parathymosin [Homo sapiens]
Length = 102
Score = 45.4 bits (106), Expect = 1e-04
Identities = 25/80 (31%), Positives = 46/80 (57%), Gaps = 1/80 (1%)
Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK-KKKKRGKKKHIKEEPLSEEEPC 507
+K++++ EK ++K + K VEEEE EEEET+ +++ G+++ +EE +E P
Sbjct: 19 EKKEKVEEKASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGEEEDEEEEEEDDEGPA 78
Query: 508 TSTAIASPEKKKKKKKKREN 527
A ++ K++K EN
Sbjct: 79 LKRAAEEEDEADPKRQKTEN 98
Score = 30.0 bits (66), Expect = 5.5
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 6/68 (8%)
Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521
A++ K +E++EKV E K +K KK+ ++EE EE TA E+ + +
Sbjct: 10 AELSAKDLKEKKEKVEE------KASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGE 63
Query: 522 KKKRENED 529
++ E E+
Sbjct: 64 EEDEEEEE 71
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 15/130 (11%)
Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA---------KKAK 463
L K E ++ K+E + T T +K K ++ +E E EKKA +K +
Sbjct: 138 LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE 197
Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523
K +E+++ K AE+ E KK+ K GK++ +K+ +E + P++K+ K+K
Sbjct: 198 TKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKE--VQKTPSKPKEKEDKEK 255
Query: 524 ----KRENED 529
K E +D
Sbjct: 256 AAVSKHEQKD 265
Score = 38.1 bits (87), Expect = 0.020
Identities = 44/191 (23%), Positives = 81/191 (42%), Gaps = 14/191 (7%)
Query: 346 LVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRK 405
+ +T K K I + +T + + G+ S + G K+ A+ +D ++
Sbjct: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT---VKIAAQAAAKKDEK-KE 378
Query: 406 ISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK---- 461
S K A+ E+ + K + K + P KK DK+ + ++AK+
Sbjct: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSP---KKEHSVPSDKQVKAKTERAKEEIGA 435
Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLS--EEEPCTSTAIASPEKK 518
IK V ++EEK + E ++K+K +K+ EP+ EE+ S PE K
Sbjct: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495
Query: 519 KKKKKKRENED 529
K +K + ++
Sbjct: 496 KDEKMSKAGKE 506
Score = 35.4 bits (80), Expect = 0.13
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 430 PSGDSTLPT--CSKKRKIEQVDKEDEITEKKA-KKAKIKVKVEEEEEEKVAEEEETSVK- 485
P+ LPT S+ +E E +KKA KK + K +E+E+ K E+ET++
Sbjct: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
+KK+ GK K+ + + E KK KK E E
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390
Score = 35.0 bits (79), Expect = 0.17
Identities = 31/94 (32%), Positives = 48/94 (51%), Gaps = 13/94 (13%)
Query: 446 EQVDKEDEITEKKAKKAKI-KVKVEEEEE----------EKVAEEEETSVKKKKKRGKKK 494
E DK EI E +K +I K K E++E+ K E+ + V++K+K KK
Sbjct: 126 EDTDK-GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184
Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
KE+ +E+P T T +A +KK K +K E +
Sbjct: 185 THKEKIEKKEKPETKT-LAKEQKKAKTAEKSEEK 217
Score = 35.0 bits (79), Expect = 0.17
Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 1/86 (1%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
KK E KE E +KK++K + + VE++E K +E ++ +VK + KK K+E
Sbjct: 321 KKVTSETKKKEKEDIKKKSEK-ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKED 379
Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526
+ + +K++KK+K E
Sbjct: 380 SKKTKKPAEVEQPKGKKQEKKEKHVE 405
Score = 34.3 bits (77), Expect = 0.29
Identities = 30/114 (26%), Positives = 58/114 (50%), Gaps = 12/114 (10%)
Query: 386 ENRAKLEARLRTL-----EDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCS 440
E + K E +++T +++G K+ K +K HK +++ + TL
Sbjct: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKP---EKKATHKEKIEKKEKPETKTL--AK 203
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK 494
+++K + +K +E T+K+ K K + KV ++ KV E ++T K K+K K+K
Sbjct: 204 EQKKAKTAEKSEEKTKKEVKGGK-QEKV-KQTAAKVKEVQKTPSKPKEKEDKEK 255
Score = 33.1 bits (74), Expect = 0.64
Identities = 31/125 (24%), Positives = 54/125 (43%), Gaps = 7/125 (5%)
Query: 412 ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ-VDKEDEITEKKAKKAKIKVKVEE 470
AL + E + K+E K + KK + E +D E + K ++ + VK+
Sbjct: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367
Query: 471 EEEEKVAEEEETSVKKKKK------RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524
+ K E++E S K KK +GKK+ KE+ + + +K+ K K +
Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427
Query: 525 RENED 529
R E+
Sbjct: 428 RAKEE 432
Score = 31.6 bits (70), Expect = 1.9
Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 9/132 (6%)
Query: 398 LEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457
LE++ K K ++T+K E K ++K + +K++ + + + T K
Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKE-KEDIKK---KSEKETAIDVEKKEPGKASETKQGTVK 364
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKK-KHIKEEPLSEEEPCTSTAIASPE 516
A +A K ++E+ +K + E K KK+ KK KH+ EP + P ++ S +
Sbjct: 365 IAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV--EP--AKSPKKEHSVPSDK 420
Query: 517 KKKKKKKKRENE 528
+ K K ++ + E
Sbjct: 421 QVKAKTERAKEE 432
Score = 31.2 bits (69), Expect = 2.5
Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 14/135 (10%)
Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449
K E +T+E ++ SG ++ K +K K + + S P K K+ +
Sbjct: 446 KEEKTTKTVEQEIRKEKSGKTSSILK-DKEPIKGKEEKVPASLKEKEPETKKDEKMSKAG 504
Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509
KE K K +++ K EE+ E ++ +E + ++ +K + K+ +K E +
Sbjct: 505 KE-----VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK--------T 551
Query: 510 TAIASPEKKKKKKKK 524
+ PE+K K+ K
Sbjct: 552 VSHGKPEEKVLKQVK 566
Score = 30.8 bits (68), Expect = 3.2
Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 422 KSEVKTYDPSGDSTLPTCSKKRKIEQVD-KEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480
K E K T+ +K + ++ + +E E K K K K E E ++
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 481 ETSVKKKKKRGKKKHIKEEPLS-EEEPCTSTAIASPEKKKKKKKKREN 527
E S K+ K++ KH++EE +S +E + EK + K E+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVED 663
>gi|4503337 dyskerin isoform 1 [Homo sapiens]
Length = 514
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/85 (34%), Positives = 42/85 (49%)
Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
+KK + +V K ++ + AK AK K + E E +E + K+KKK K K K
Sbjct: 423 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 482
Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
S EP + + +KKKKKK K
Sbjct: 483 LESGAEPGDGDSDTTKKKKKKKKAK 507
Score = 32.3 bits (72), Expect = 1.1
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)
Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
AKT K + +SE ++ D T P Q+ K+++ KK KKAK +E E
Sbjct: 442 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 488
Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499
+ + T KKKKK+ K+ + E
Sbjct: 489 PGDGDSDTTKKKKKKKKAKEVELVSE 514
Score = 29.3 bits (64), Expect = 9.3
Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 8/67 (11%)
Query: 459 AKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKK 518
++ AK +V E + +V E + K+K++ E S+E P + + EKK
Sbjct: 420 SESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--------SESESDETPPAAPQLIKKEKK 471
Query: 519 KKKKKKR 525
K KK K+
Sbjct: 472 KSKKDKK 478
>gi|215599015 dyskerin isoform 2 [Homo sapiens]
Length = 509
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/85 (34%), Positives = 42/85 (49%)
Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499
+KK + +V K ++ + AK AK K + E E +E + K+KKK K K K
Sbjct: 418 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 477
Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524
S EP + + +KKKKKK K
Sbjct: 478 LESGAEPGDGDSDTTKKKKKKKKAK 502
Score = 32.3 bits (72), Expect = 1.1
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%)
Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473
AKT K + +SE ++ D T P Q+ K+++ KK KKAK +E E
Sbjct: 437 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 483
Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499
+ + T KKKKK+ K+ + E
Sbjct: 484 PGDGDSDTTKKKKKKKKAKEVELVSE 509
Score = 31.6 bits (70), Expect = 1.9
Identities = 27/93 (29%), Positives = 44/93 (47%), Gaps = 16/93 (17%)
Query: 441 KKRKIEQ--VDKEDEITE------KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492
KK I+Q +DK + T+ K+ + AK +V E + +V E + K+K++
Sbjct: 389 KKLMIKQGLLDKHGKPTDSTPATWKQDESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--- 445
Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525
E S+E P + + EKKK KK K+
Sbjct: 446 -----SESESDETPPAAPQLIKKEKKKSKKDKK 473
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 8/149 (5%)
Query: 388 RAKLEARLRTLEDRGI------RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441
R K E + R +RG ++ K + E+ + K E K + K
Sbjct: 58 RGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKK 117
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK--RGKKKHIKEE 499
K + E+ + + E+K KK + K + +E + EK + E KK+KK R KK+ +
Sbjct: 118 KERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177
Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENE 528
+E E+KK+++KK+E +
Sbjct: 178 ERKKERERKERRERKKERKKERRKKKERK 206
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 21/141 (14%)
Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447
R K R R +++ RK GK + K K + + +KRK E+
Sbjct: 50 REKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE--------RRKRKKEK 101
Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPC 507
+E + ++ +K K K + E E E K E + ++KKKR K++ ++E
Sbjct: 102 KKRERKQRGRRERKKK-KERKERERENKQRRERKRKKRRKKKRRKERKREKER------- 153
Query: 508 TSTAIASPEKKKKKKKKRENE 528
E+K+KK+KK E E
Sbjct: 154 -----GKRERKRKKRKKEERE 169
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/89 (31%), Positives = 46/89 (51%), Gaps = 13/89 (14%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
K+RK E+ KE + KK ++ K + + +E E++ E E +K+KK KK+ K+
Sbjct: 52 KERKRERGKKEKK-KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRG 110
Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENED 529
E KKKK++K+RE E+
Sbjct: 111 RRE------------RKKKKERKEREREN 127
Score = 40.4 bits (93), Expect = 0.004
Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 14/143 (9%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
E R K + + + + RK G + K E+ E + E K KKR+
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK-------QRRERKRKKRRK 140
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
++ KE + +++ K+ + + K ++EE EK E KK+++R +++ K+E E
Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200
Query: 506 PCTSTAIASPEKKKKKKKKRENE 528
E+KK +K R+ +
Sbjct: 201 K-------KKERKKDRKTDRQTD 216
Score = 38.9 bits (89), Expect = 0.012
Identities = 21/74 (28%), Positives = 39/74 (52%)
Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514
+E+K ++ + + + E E+E+ E + KK+KKR + K + + E+
Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 515 PEKKKKKKKKRENE 528
K+KK+KKKRE +
Sbjct: 94 RRKRKKEKKKRERK 107
Score = 38.5 bits (88), Expect = 0.015
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 7/88 (7%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500
+KRK E+ +KE + K +K K K + +E E+ +E E K+++++ ++K KE+
Sbjct: 44 EKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKK 102
Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528
E + ++KKKK+++E E
Sbjct: 103 KRERKQ------RGRRERKKKKERKERE 124
Score = 37.0 bits (84), Expect = 0.045
Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 453 EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLSEEEPCTSTA 511
E KK ++ + K K E E+E K E K+KKKR K++ KE E +E
Sbjct: 33 ESERKKERREREKRKREREKERK----RERGKKEKKKRKKRERGKERERKRKEREKQRKE 88
Query: 512 IASPEKKKKKKKKRENE 528
E++K+KK+K++ E
Sbjct: 89 RREKERRKRKKEKKKRE 105
Score = 33.9 bits (76), Expect = 0.38
Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 14/120 (11%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
E + K E + R E++ R+ + K K + + E K G KKRK
Sbjct: 113 ERKKKKERKERERENKQRRE-----RKRKKRRKKKRRKERKREKERGKRERKR--KKRKK 165
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
E+ +K+ E K+ KK E E +E+ ++E +++KK+ +KK K + ++ +
Sbjct: 166 EEREKKRERNRKERKK-------ERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 44.7 bits (104), Expect = 2e-04
Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 29/223 (13%)
Query: 336 PKYGL---IYHASLVG---QTSPKHKGKISRMLAAKTVLAIRYD----AFGEDSSSAMGV 385
PKYGL ++ + +G T K K R + A T +++ + SS A V
Sbjct: 267 PKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSV 326
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKAL-AKTEKYEHKSEVKTY-DPSGDSTLPTCSKKR 443
+R L R RKISGT A EK +H ++ D S
Sbjct: 327 SSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG 386
Query: 444 KIEQV-----DKEDE-ITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497
+IEQ D D+ + E +AK +++ VE + EKV + +K+K + ++
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 498 EEPLSEEEPCTSTAIASP-----------EKKKKKKKKRENED 529
EE +++ + T T + EK K K +RE ED
Sbjct: 447 EESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED 489
Score = 30.0 bits (66), Expect = 5.5
Identities = 29/144 (20%), Positives = 59/144 (40%), Gaps = 30/144 (20%)
Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445
+ AKL+ L TL++ ++ + E+ E+ T + +K+
Sbjct: 1103 QTNAKLQNELDTLKENNLKNV----------EELNKSKELLTVE------------NQKM 1140
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505
E+ KE E ++ A + ++ +EE K+AEE R + + + L EE
Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE--------LGRSRDEVTSHQKLEEER 1192
Query: 506 PCTSTAIASPEKKKKKKKKRENED 529
+ + +K++ K K +E+
Sbjct: 1193 SVLNNQLLEMKKRESKFIKDADEE 1216
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 44.3 bits (103), Expect = 3e-04
Identities = 50/204 (24%), Positives = 82/204 (40%), Gaps = 26/204 (12%)
Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
QTS +GK + A Y + DS + VE R + A+ + E+R +R+
Sbjct: 454 QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK--EERLLRRQIN 511
Query: 409 TGKALAKTEKYEHKSEVK--------TYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460
K K ++ K++ + D ST K +I++V KE ++ EKK
Sbjct: 512 REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA 571
Query: 461 KAKIKVK----VEEEEEEKVAEEEETSVKKK------------KKRGKKKHIKEEPLSEE 504
+K + K VEE ++K EE++ K K K H K EP
Sbjct: 572 LSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPA 631
Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528
+ + E K + K +RE++
Sbjct: 632 RRLSESLHVVDENKNESKLEREHK 655
Score = 34.3 bits (77), Expect = 0.29
Identities = 24/96 (25%), Positives = 47/96 (48%), Gaps = 11/96 (11%)
Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRG--------- 491
+KR+ + + +E + + K+K +VKV E E ++ A ++ T+ K K++
Sbjct: 896 EKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955
Query: 492 KKKHIKEEPLSEE--EPCTSTAIASPEKKKKKKKKR 525
+K ++++P E EP TA +S +K R
Sbjct: 956 RKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991
Score = 31.2 bits (69), Expect = 2.5
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 18/163 (11%)
Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKT-----YD 429
E S +G + + E ++T D +RK + + EK EHKS + D
Sbjct: 796 ERKLSVLGKDGKPVSEYIIKT--DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKD 853
Query: 430 PSGDS----TLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK 485
G TL S+ ++ D + + K ++ V E+ + + EE+
Sbjct: 854 SLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEV-VHKEKRRTKSLLEEKLVLKS 912
Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528
K K +GK+ + E L E +T A+ K K+K EN+
Sbjct: 913 KSKTQGKQVKVVETELQE----GATKQATTPKPDKEKNTEEND 951
Score = 30.4 bits (67), Expect = 4.2
Identities = 32/129 (24%), Positives = 57/129 (44%), Gaps = 20/129 (15%)
Query: 396 RTLEDRGIRKISGT---GKALAKTEKYEHKS-------EVKTYDPSGDSTLPTCSKKRKI 445
RT ED ++ S G+ L K E S E+K Y ++ + +K +
Sbjct: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLI-LLNKDVQQ 309
Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE---------EETSVKKKKKRGKKKHI 496
E +++++ T+K KK K E ++E+K E E+T K +K+ K+K +
Sbjct: 310 ESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV 369
Query: 497 KEEPLSEEE 505
+ L E+
Sbjct: 370 ESLKLPSEK 378
Score = 30.4 bits (67), Expect = 4.2
Identities = 24/123 (19%), Positives = 53/123 (43%), Gaps = 6/123 (4%)
Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---EKKAKKAK 463
S T + E+ S++K + ++R I D E++I ++ +K K
Sbjct: 2893 SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPK 2952
Query: 464 IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKK 520
+ V ++ E E ++ S + K+ ++ +EE E+EP +T ++ + +
Sbjct: 2953 RSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQ 3012
Query: 521 KKK 523
+ K
Sbjct: 3013 RSK 3015
Score = 29.3 bits (64), Expect = 9.3
Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 5/79 (6%)
Query: 449 DKEDEITEKKAK---KAKIKVKVEEEEEEKVAEEEETSVK--KKKKRGKKKHIKEEPLSE 503
D + E +E+K K K + K E+ E K ++E+T K KK + +K+E ++
Sbjct: 306 DVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAK 365
Query: 504 EEPCTSTAIASPEKKKKKK 522
E+ S + S + K K
Sbjct: 366 EKEVESLKLPSEKNSNKAK 384
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 43.9 bits (102), Expect = 4e-04
Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 6/154 (3%)
Query: 370 IRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD 429
I+ A ++S A +KL R +E+ S K LAKTEK +S K
Sbjct: 313 IKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEK--- 369
Query: 430 PSGDSTLPTCSKKRKIEQVDKED-EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKK 488
P P K E + E ++ + K K +K K+ + EE+K E++E +KK++
Sbjct: 370 PPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKE--IKKER 427
Query: 489 KRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522
K KK ++E + + PE KK K
Sbjct: 428 KELKKDEGRKEEKKDAKKEEKRKDTKPELKKISK 461
Score = 37.4 bits (85), Expect = 0.034
Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 11/90 (12%)
Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK-----RGKKKHI 496
K ++ KE TEKKAK++ K + + E+V E ++K +K+ + KKH+
Sbjct: 346 KEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHL 405
Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
KE+ EE EKK+ KK+++E
Sbjct: 406 KEKISKLEEK------KDKEKKEIKKERKE 429
Score = 37.0 bits (84), Expect = 0.045
Identities = 30/120 (25%), Positives = 49/120 (40%), Gaps = 4/120 (3%)
Query: 411 KALAKTEKYEH----KSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
K L EK H + V T +PT K KI+Q E + K A K+
Sbjct: 275 KILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKL 334
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526
EE E+ A+E + + K+ + +KK + E+P + + + K +KR+
Sbjct: 335 AKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRK 394
Score = 32.0 bits (71), Expect = 1.4
Identities = 24/84 (28%), Positives = 46/84 (54%), Gaps = 8/84 (9%)
Query: 441 KKRKIEQVDK----EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496
K +EQ DK +D+ E+K K + K K+ E E++K E+++T++++K K +
Sbjct: 1418 KDTALEQKDKALEPKDKDLEEKDKALEQKDKIPE-EKDKALEQKDTALEQKDKALEP--- 1473
Query: 497 KEEPLSEEEPCTSTAIASPEKKKK 520
K++ L +++ PE+K K
Sbjct: 1474 KDKDLEQKDRVLEQKEKIPEEKDK 1497
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K
Sbjct: 1271 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1329
Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
+ ++E EE++ + T S K+KKK K+K KE E + + +
Sbjct: 1330 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1389
Query: 509 STAIASPEKKKKKKKKRENE 528
+ SP +KKKKKKK+ E
Sbjct: 1390 TKDSESPSQKKKKKKKKTAE 1409
Score = 34.3 bits (77), Expect = 0.29
Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)
Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
VG +P+ G + + +A EDSSS+ ++ E G+
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634
Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
G K++ K + + S V G T P K +T+ KA+K +
Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
E EEE +EE S + K KK K P + P I++P K
Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)
Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
+TS KGK R A+ V + G+ S + G ++ + E + +G+ + G
Sbjct: 1305 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1354
Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
++ K++K + KS+ KRK ++ KE +KKAKKA K
Sbjct: 1355 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1391
Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492
+ E S KKKKK+ K
Sbjct: 1392 ---------DSESPSQKKKKKKKK 1406
Score = 29.6 bits (65), Expect = 7.1
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
+A K+ ++ E+E +KV + + S +K + K+K LS ++P T P
Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1285
Query: 518 KKKKK 522
KKKKK
Sbjct: 1286 KKKKK 1290
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K
Sbjct: 1310 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1368
Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
+ ++E EE++ + T S K+KKK K+K KE E + + +
Sbjct: 1369 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1428
Query: 509 STAIASPEKKKKKKKKRENE 528
+ SP +KKKKKKK+ E
Sbjct: 1429 TKDSESPSQKKKKKKKKTAE 1448
Score = 34.3 bits (77), Expect = 0.29
Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)
Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
VG +P+ G + + +A EDSSS+ ++ E G+
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711
Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
G K++ K + + S V G T P K +T+ KA+K +
Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
E EEE +EE S + K KK K P + P I++P K
Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)
Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
+TS KGK R A+ V + G+ S + G ++ + E + +G+ + G
Sbjct: 1344 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1393
Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
++ K++K + KS+ KRK ++ KE +KKAKKA K
Sbjct: 1394 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1430
Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492
+ E S KKKKK+ K
Sbjct: 1431 ---------DSESPSQKKKKKKKK 1445
Score = 29.6 bits (65), Expect = 7.1
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
+A K+ ++ E+E +KV + + S +K + K+K LS ++P T P
Sbjct: 1275 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1324
Query: 518 KKKKK 522
KKKKK
Sbjct: 1325 KKKKK 1329
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K
Sbjct: 1347 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1405
Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
+ ++E EE++ + T S K+KKK K+K KE E + + +
Sbjct: 1406 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1465
Query: 509 STAIASPEKKKKKKKKRENE 528
+ SP +KKKKKKK+ E
Sbjct: 1466 TKDSESPSQKKKKKKKKTAE 1485
Score = 34.3 bits (77), Expect = 0.29
Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)
Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
VG +P+ G + + +A EDSSS+ ++ E G+
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711
Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
G K++ K + + S V G T P K +T+ KA+K +
Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
E EEE +EE S + K KK K P + P I++P K
Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)
Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
+TS KGK R A+ V + G+ S + G ++ + E + +G+ + G
Sbjct: 1381 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1430
Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
++ K++K + KS+ KRK ++ KE +KKAKKA K
Sbjct: 1431 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1467
Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492
+ E S KKKKK+ K
Sbjct: 1468 ---------DSESPSQKKKKKKKK 1482
Score = 29.6 bits (65), Expect = 7.1
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
+A K+ ++ E+E +KV + + S +K + K+K LS ++P T P
Sbjct: 1312 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1361
Query: 518 KKKKK 522
KKKKK
Sbjct: 1362 KKKKK 1366
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 43.9 bits (102), Expect = 4e-04
Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460
RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K
Sbjct: 1270 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1328
Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508
+ ++E EE++ + T S K+KKK K+K KE E + + +
Sbjct: 1329 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1388
Query: 509 STAIASPEKKKKKKKKRENE 528
+ SP +KKKKKKK+ E
Sbjct: 1389 TKDSESPSQKKKKKKKKTAE 1408
Score = 34.3 bits (77), Expect = 0.29
Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%)
Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406
VG +P+ G + + +A EDSSS+ ++ E G+
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634
Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466
G K++ K + + S V G T P K +T+ KA+K +
Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685
Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
E EEE +EE S + K KK K P + P I++P K
Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734
Score = 31.2 bits (69), Expect = 2.5
Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%)
Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408
+TS KGK R A+ V + G+ S + G ++ + E + +G+ + G
Sbjct: 1304 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1353
Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468
++ K++K + KS+ KRK ++ KE +KKAKKA K
Sbjct: 1354 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1390
Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492
+ E S KKKKK+ K
Sbjct: 1391 ---------DSESPSQKKKKKKKK 1405
Score = 29.6 bits (65), Expect = 7.1
Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%)
Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517
+A K+ ++ E+E +KV + + S +K + K+K LS ++P T P
Sbjct: 1235 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1284
Query: 518 KKKKK 522
KKKKK
Sbjct: 1285 KKKKK 1289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,410,898
Number of Sequences: 37866
Number of extensions: 841474
Number of successful extensions: 20344
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 440
Number of HSP's successfully gapped in prelim test: 558
Number of HSP's that attempted gapping in prelim test: 7543
Number of HSP's gapped (non-prelim): 6449
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.