BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] (529 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] 1032 0.0 gi|32483374 nucleolar protein 5A [Homo sapiens] 345 6e-95 gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens] 129 5e-30 gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens] 77 3e-14 gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens] 77 3e-14 gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo sap... 77 3e-14 gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 53 6e-07 gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 53 8e-07 gi|221219020 NYD-SP11 protein [Homo sapiens] 52 1e-06 gi|153945728 microtubule-associated protein 1B [Homo sapiens] 51 3e-06 gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 50 4e-06 gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 49 1e-05 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 1e-05 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 48 2e-05 gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 47 6e-05 gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 46 7e-05 gi|239750213 PREDICTED: hypothetical protein [Homo sapiens] 46 1e-04 gi|11225260 DNA topoisomerase I [Homo sapiens] 45 1e-04 gi|46276863 parathymosin [Homo sapiens] 45 1e-04 gi|104526627 triadin [Homo sapiens] 45 1e-04 gi|4503337 dyskerin isoform 1 [Homo sapiens] 45 2e-04 gi|215599015 dyskerin isoform 2 [Homo sapiens] 45 2e-04 gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 45 2e-04 gi|4506751 restin isoform a [Homo sapiens] 45 2e-04 gi|87299628 biorientation of chromosomes in cell division 1-like... 44 3e-04 gi|95147555 microtubule-associated protein 1A [Homo sapiens] 44 4e-04 gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 44 4e-04 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 44 4e-04 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 44 4e-04 gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 44 4e-04 >gi|7706254 NOP58 ribonucleoprotein homolog [Homo sapiens] Length = 529 Score = 1032 bits (2668), Expect = 0.0 Identities = 529/529 (100%), Positives = 529/529 (100%) Query: 1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF Sbjct: 1 MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAF 60 Query: 61 TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120 TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR Sbjct: 61 TALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIR 120 Query: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI Sbjct: 121 SQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYI 180 Query: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI Sbjct: 181 MRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEI 240 Query: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA Sbjct: 241 SMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIA 300 Query: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR Sbjct: 301 HAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISR 360 Query: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE Sbjct: 361 MLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYE 420 Query: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE Sbjct: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480 Query: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED Sbjct: 481 ETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 >gi|32483374 nucleolar protein 5A [Homo sapiens] Length = 594 Score = 345 bits (885), Expect = 6e-95 Identities = 213/550 (38%), Positives = 322/550 (58%), Gaps = 32/550 (5%) Query: 3 VLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPE----KANKIVKLKHFEKFQDTAEALA 58 VLFE +VGYA+ + K+++E+ L + E K + IV+L F F + AL Sbjct: 6 VLFEHAVGYALLAL---KEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVALE 62 Query: 59 AFTALMEGKINKQLKKVLKKIV--KEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELM 116 A+ EG +++ L+ +L+ + K+ L V D K+G I+E+L +C V+ E++ Sbjct: 63 NANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAEIL 122 Query: 117 RGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKEL 176 RG+R L+ G+ LGL HS SR ++KF+ ++VD MI+Q+ISLLD LDK++ Sbjct: 123 RGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDKDI 182 Query: 177 NNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVE-AEVK 235 N + MR REWYG+HFPEL KII+DN TYC+ Q +G+R+ KL +L ++ A+ K Sbjct: 183 NTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAKAK 242 Query: 236 A---AAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGE 292 A A+ SMG ++S D+ NI ++V+ +SEYR L+ YL+++M +AP+++ ++GE Sbjct: 243 AILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALIGE 302 Query: 293 LVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSP 352 VGARLIAHAGSL NLAK+ ASTVQILGAEKALFRALK+R +TPKYGLI+H++ +G+ + Sbjct: 303 AVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRAAA 362 Query: 353 KHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLR-------------TLE 399 K+KG+ISR LA K +A R D F E +S G + R ++E RL ++ Sbjct: 363 KNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDVMK 422 Query: 400 DRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459 + ++ + K EK E K K + + L S + ++ +E++EK Sbjct: 423 EAMVQAEEAAAEITRKLEKQEKKRLKK--EKKRLAALALASSENSSSTPEECEEMSEKPK 480 Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK 519 KK K K +E +E E+ S K KK KK KEE +S + T+ + + P++KK Sbjct: 481 KKK--KQKPQEVPQENGMEDPSISFSKPKK--KKSFSKEELMSSDLEETAGSTSIPKRKK 536 Query: 520 KKKKKRENED 529 K+ D Sbjct: 537 STPKEETVND 546 >gi|221136939 pre-mRNA processing factor 31 homolog [Homo sapiens] Length = 499 Score = 129 bits (325), Expect = 5e-30 Identities = 70/236 (29%), Positives = 129/236 (54%), Gaps = 2/236 (0%) Query: 161 MIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDR--KNYA 218 +IV A +L +++ ELN R+ Y FPEL ++ + L Y + ++++G+ K Sbjct: 92 VIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKN 151 Query: 219 SAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNR 278 + L ++L V A + G ++SEE++ + C +E++ + ++YEY+++R Sbjct: 152 NENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESR 211 Query: 279 MMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKY 338 M IAPN+++++G A+++ AG L NL+K A + +LGA++ S P Sbjct: 212 MSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHT 271 Query: 339 GLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEAR 394 G IYH+ +V P + K +R++AAK LA R D+F E + +G E + ++E + Sbjct: 272 GYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERK 327 >gi|169183877 PREDICTED: similar to hCG1742476 [Homo sapiens] Length = 278 Score = 77.4 bits (189), Expect = 3e-14 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%) Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390 ++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + + Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61 Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450 +E RL E TG+ L+K +KT + T +K + ++ + Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107 Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510 E T K KK K K K +E +E ++ S K KR K KE+ +S T+ Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164 Query: 511 AIASPEKKKKKKKKRENED 529 +I+ P +K K+ D Sbjct: 165 SISLPNRKTSSPKEEAVND 183 >gi|169179771 PREDICTED: similar to hCG1742476 [Homo sapiens] Length = 278 Score = 77.4 bits (189), Expect = 3e-14 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%) Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390 ++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + + Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61 Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450 +E RL E TG+ L+K +KT + T +K + ++ + Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107 Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510 E T K KK K K K +E +E ++ S K KR K KE+ +S T+ Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164 Query: 511 AIASPEKKKKKKKKRENED 529 +I+ P +K K+ D Sbjct: 165 SISLPNRKTSSPKEEAVND 183 >gi|239743692 PREDICTED: hypothetical protein LOC402360 [Homo sapiens] Length = 278 Score = 77.4 bits (189), Expect = 3e-14 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 17/199 (8%) Query: 331 SRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAK 390 ++ +TPKYGL++H++ GQ + ++KG+IS+ LA K +A + D F E S G + + + Sbjct: 2 TKGNTPKYGLVFHSTFTGQAAARNKGRISQYLANKCSIASQIDCFAEVLMSIFGEKLQEQ 61 Query: 391 LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDK 450 +E RL E TG+ L+K +KT + T +K + ++ + Sbjct: 62 VEERLSFYE---------TGEILSK-----KMDVMKTEMVQAEKTAAEIIRKLEKQETPE 107 Query: 451 EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTST 510 E T K KK K K K +E +E ++ S K KR K KE+ +S T+ Sbjct: 108 ECAKTSVKPKKKK-KQKPQEAPQENGIKDPSNSFSKPNKR--KSFSKEKLVSSHREETAG 164 Query: 511 AIASPEKKKKKKKKRENED 529 +I+ P +K K+ D Sbjct: 165 SISLPNRKTSSPKEEAVND 183 >gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapiens] Length = 123 Score = 53.1 bits (126), Expect = 6e-07 Identities = 31/97 (31%), Positives = 52/97 (53%) Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492 + T T + + E+ K E ++K K+ + K K +E E+ K EEEE K+K+K+ K Sbjct: 11 EETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKK 70 Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 ++ +EE EEE +++KKKKKR ++ Sbjct: 71 EEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKE 107 Score = 52.8 bits (125), Expect = 8e-07 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 15/104 (14%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEE-----------EEEKVAEEEETSVKKKKK 489 KK++ E+ ++ +E E++ K+ K K K +E+ E EK E+EE K+K+K Sbjct: 6 KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRK 65 Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPE----KKKKKKKKRENED 529 R KKK +E EEE E +KKKKK++R+ E+ Sbjct: 66 RKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109 Score = 51.2 bits (121), Expect = 2e-06 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 19/127 (14%) Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---------EKKAKK 461 K +TE+ E E + + +KRK ++ K+ + T EKK K+ Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64 Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521 + K K EEE EE+ EEEE +++K+ G+++ K++ +EE E++KKK Sbjct: 65 KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEE----------EEEKKK 114 Query: 522 KKKRENE 528 K++R+ + Sbjct: 115 KRRRKTK 121 Score = 50.4 bits (119), Expect = 4e-06 Identities = 28/72 (38%), Positives = 41/72 (56%) Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 K KK K K E EE E+ EEEE K+K+KR +K+ KE+ +E EK Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60 Query: 518 KKKKKKKRENED 529 K+K+K+K++ E+ Sbjct: 61 KRKRKRKKKKEE 72 Score = 49.3 bits (116), Expect = 9e-06 Identities = 34/92 (36%), Positives = 51/92 (55%), Gaps = 14/92 (15%) Query: 441 KKRKIEQVDKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHI 496 KK+K ++ +K E E+ K +K K K K EEEE E+ EEEE ++++K R +KK Sbjct: 42 KKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101 Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528 K EEE EKKKK+++K + + Sbjct: 102 KRRRKEEEE----------EKKKKRRRKTKKK 123 Score = 48.5 bits (114), Expect = 1e-05 Identities = 26/74 (35%), Positives = 42/74 (56%) Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515 +KK KK K + EE EE + EE+E K+K+K +K+ K++ E E Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60 Query: 516 EKKKKKKKKRENED 529 ++K+K+KKK+E E+ Sbjct: 61 KRKRKRKKKKEEEE 74 Score = 38.5 bits (88), Expect = 0.015 Identities = 30/119 (25%), Positives = 55/119 (46%), Gaps = 10/119 (8%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 + + + E T E + G K K ++ E + + KT + KKRK Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKR 64 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEE----------KVAEEEETSVKKKKKRGKKK 494 ++ K++E ++ ++ + + K EEE+EE + EEEE KK++++ KKK Sbjct: 65 KRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123 >gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo sapiens] Length = 956 Score = 52.8 bits (125), Expect = 8e-07 Identities = 29/87 (33%), Positives = 46/87 (52%) Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501 K + E+ +KE E K K + K K EEE+E K E E K +K++ +K+ +KEE Sbjct: 349 KLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERR 408 Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528 E + + KK+++K+ RE E Sbjct: 409 KERQEALEAKLEEKRKKEEEKRLREEE 435 Score = 37.7 bits (86), Expect = 0.026 Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 6/93 (6%) Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469 GK L + E K ++K KK++ E+ KE E EK+ K K K + + Sbjct: 345 GKQLKLRAEREEKEKLKE---EAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQ 401 Query: 470 EEEEEKVAEEE---ETSVKKKKKRGKKKHIKEE 499 +EE+ E + E +++K+K+ ++K ++EE Sbjct: 402 RLKEERRKERQEALEAKLEEKRKKEEEKRLREE 434 Score = 30.8 bits (68), Expect = 3.2 Identities = 28/124 (22%), Positives = 63/124 (50%), Gaps = 15/124 (12%) Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449 +L+ R E +++ + K AK +K E K E+K + +KR+ ++ + Sbjct: 347 QLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEK-ELKEKERR---------EKREKDEKE 396 Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK-----EEPLSEE 504 K ++ K+ ++ + + +E + EEK +EEE +++++KR K + + ++P + + Sbjct: 397 KAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQ 456 Query: 505 EPCT 508 P T Sbjct: 457 APKT 460 >gi|221219020 NYD-SP11 protein [Homo sapiens] Length = 2873 Score = 52.4 bits (124), Expect = 1e-06 Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 29/191 (15%) Query: 357 KISRMLAAKTVLAIRYDAFGEDSSSAMGVENRA-----KLEARLRTLEDRGIRKISGTGK 411 K +M ++ LA ++ D G+E K R R RG + Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215 Query: 412 ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI-----EQVDKEDEITEKKAKKAKIKV 466 + + E EH SE +S L K+ + E+ ++E+E E++ ++ + + Sbjct: 2216 QVDEVESEEHFSEEM------ESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHI---------KEEPLSEEEPCTSTAIASPEK 517 K EEE EEK E+EE KKKKK KK+ + KEE +SEEE T S E+ Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE----TESLSDEE 2325 Query: 518 KKKKKKKRENE 528 ++++ E E Sbjct: 2326 EEEESCSLEEE 2336 Score = 42.4 bits (98), Expect = 0.001 Identities = 34/149 (22%), Positives = 76/149 (51%), Gaps = 8/149 (5%) Query: 379 SSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPT 438 SS VE+ + +L D ++ S + + + E+ E + E + + + Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273 Query: 439 CSKKRKIEQVDKEDEITEKKAKKAKIKVKVE--EEEEEKVAEEEETSVKKKKKRGKKKHI 496 +++++E+ ++E + +K+ KK +++ K E EE+EE ++EEE S+ +++ + + Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL 2333 Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKR 525 +EE E+E I EK+ K +++R Sbjct: 2334 EEEVDREKE------ILKKEKQFKLQEQR 2356 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/92 (28%), Positives = 51/92 (55%), Gaps = 15/92 (16%) Query: 444 KIEQVDKEDEITEK------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497 ++++V+ E+ +E+ + +K + EEEE E+ E EE V+++++ K++ Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275 Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 EE E+E E+KKKKKK+++ E+ Sbjct: 2276 EEKQVEKEE---------EEKKKKKKEKKKEE 2298 Score = 38.1 bits (87), Expect = 0.020 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 16/90 (17%) Query: 450 KEDEITEKKAKKAKIKVKVEE-------------EEEEKVAEEEETSVKKKKKRGKKKHI 496 KE+E+ +++ K + K K+ E EEE K+A+EEE +++K+K + Sbjct: 1731 KEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH--- 1787 Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 KE+ EEE EKK K +KRE Sbjct: 1788 KEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817 Score = 35.4 bits (80), Expect = 0.13 Identities = 34/141 (24%), Positives = 61/141 (43%), Gaps = 24/141 (17%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 E + E +R E+ + G K + K E+ + K + K++K Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK----------------KEKKK 2296 Query: 446 EQVDKEDEITEKK----AKKAKIKVKVEEEEEEKVAEEEETS----VKKKKKRGKKKHIK 497 E+V +++E+ E+K +++ + EEEEEE + EEE + KK+K+ K + + Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356 Query: 498 EEPLSEEEPCTSTAIASPEKK 518 + L E S P K Sbjct: 2357 RKSLRGRERVLSILRGVPHGK 2377 Score = 34.3 bits (77), Expect = 0.29 Identities = 22/70 (31%), Positives = 42/70 (60%), Gaps = 4/70 (5%) Query: 440 SKKRKIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETS-VKKKKKRGKKKHI 496 S K K +Q E+E+T E+ +++ + K + EE+ + EE + + + +K+ R +KK Sbjct: 1530 SSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRA 1589 Query: 497 KEE-PLSEEE 505 +EE L++EE Sbjct: 1590 QEERKLAQEE 1599 Score = 34.3 bits (77), Expect = 0.29 Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 4/122 (3%) Query: 382 AMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441 A + RA+ E +L E+ K++ + LA+ E+ ++ VK + Sbjct: 1582 ARAEKKRAQEERKLAQEEE----KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637 Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501 +K E + + E ++A+K K K ++ EKVA EEE KK K + K+I + + Sbjct: 1638 AQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKV 1697 Query: 502 SE 503 E Sbjct: 1698 EE 1699 Score = 33.5 bits (75), Expect = 0.49 Identities = 29/118 (24%), Positives = 58/118 (49%), Gaps = 29/118 (24%) Query: 441 KKRKI-----EQVDKEDEITEKKAKKAK--IKVKVEEEEEEKVAEEE-------ETSVKK 486 K+RK+ ++KE+++TE+++K A+ +V +++EEE + EEE +K Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRK 2201 Query: 487 KKKRGKK---------------KHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 + KRG K +H EE S + S E++++++++ E E+ Sbjct: 2202 EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREE 2259 Score = 32.0 bits (71), Expect = 1.4 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 25/138 (18%) Query: 414 AKTEKYEHKSEVKTYDPSG----DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469 +K ++Y+ + EV + + ++R I++ K I K+A+ K + + E Sbjct: 1533 SKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEE 1592 Query: 470 E---EEEEKVAEEEETSVKKKKKRGK-----------------KKHIKEEPLSEE-EPCT 508 +EEEK+A+EE ++++K + K KEE L++ E + Sbjct: 1593 RKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLS 1652 Query: 509 STAIASPEKKKKKKKKRE 526 A +K+KK KK E Sbjct: 1653 QEAEKLAQKRKKLAKKWE 1670 Score = 31.6 bits (70), Expect = 1.9 Identities = 28/129 (21%), Positives = 56/129 (43%), Gaps = 6/129 (4%) Query: 401 RGIRKISGTGKALAKTE----KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITE 456 RG++K TE + E +E + S S + ++ K+ + E Sbjct: 1098 RGLKKTKERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDVDSQE 1157 Query: 457 KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPE 516 K K I + ++ ++ + +++ + +K KK+ KKK + + ++EE T + P Sbjct: 1158 KDISKDHIALTLKRLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEE--TTPPVMEQPV 1215 Query: 517 KKKKKKKKR 525 KK K + R Sbjct: 1216 TKKVKIQGR 1224 Score = 31.6 bits (70), Expect = 1.9 Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 16/95 (16%) Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVK------VEEEEEEKVAEEEETSVKKKKK--RGKK 493 +RK + ++ +T K + ++K K + + EEK+ +E+ET +KKK+K +K Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEK 1914 Query: 494 KHI--------KEEPLSEEEPCTSTAIASPEKKKK 520 K + K+E L++E+ + A + KK+ Sbjct: 1915 KLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKR 1949 Score = 29.3 bits (64), Expect = 9.3 Identities = 24/109 (22%), Positives = 49/109 (44%), Gaps = 11/109 (10%) Query: 421 HKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKV 476 H+ + ++ K+ Q +++ E+K +A +K+ ++ E E K Sbjct: 1578 HRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKF 1637 Query: 477 AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS---TAIASPEKKKKKK 522 A++EET +RG+K + E L+++ + +A E+K KK Sbjct: 1638 AQKEETLA----QRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682 >gi|153945728 microtubule-associated protein 1B [Homo sapiens] Length = 2468 Score = 50.8 bits (120), Expect = 3e-06 Identities = 47/204 (23%), Positives = 88/204 (43%), Gaps = 7/204 (3%) Query: 330 KSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKT-----VLAIRYDAFGEDSSSAMG 384 +S+ +TP+ + H + K K + + KT V + E S Sbjct: 560 ESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAE 619 Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444 V + + + + +++ ++K + K EK + K EV + KK + Sbjct: 620 VAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679 Query: 445 IE-QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE 503 ++ +V KE + EKK K ++K + +E +K ++EE KK+++ KK IK+ P Sbjct: 680 VKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDA 739 Query: 504 EEPCTSTAIA-SPEKKKKKKKKRE 526 ++ T + A P K K K+E Sbjct: 740 KKSSTPLSEAKKPAALKPKVPKKE 763 Score = 48.9 bits (115), Expect = 1e-05 Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 3/92 (3%) Query: 438 TCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497 T K+ K++ DK++E + K + AK + K ++EEK +EE VKK+ K+ KK K Sbjct: 637 TVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE---VKKEVKKEIKKEEK 693 Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 +EP E + T E KK++KK+ + E+ Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE 725 Score = 47.0 bits (110), Expect = 4e-05 Identities = 39/142 (27%), Positives = 70/142 (49%), Gaps = 20/142 (14%) Query: 405 KISGTGKALAKTEK---YEHKSEVKTYD-PSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460 K+ K + K +K E K V + PS + P ++ + + D + + ++K Sbjct: 579 KVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTV 638 Query: 461 KAKIKVKVEEEEEEK-------VAEEEETSVKKKKKRGK-------KKHIKEEPLSEEEP 506 K + KVK E+++EEK +E++T +KK++K K KK IK+E ++EP Sbjct: 639 KKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE--EKKEP 696 Query: 507 CTSTAIASPEKKKKKKKKRENE 528 +P K+ KK+ K+E + Sbjct: 697 KKEVKKETPPKEVKKEVKKEEK 718 Score = 39.7 bits (91), Expect = 0.007 Identities = 30/109 (27%), Positives = 53/109 (48%), Gaps = 14/109 (12%) Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474 K +K E K EVK K+ K E+ + + +K+ ++K +V++EE++ Sbjct: 674 KPKKEEVKKEVK--------------KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKK 719 Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523 +V +EE+ K+ KK K PLSE + + P+K++ KK Sbjct: 720 EVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKK 768 Score = 38.5 bits (88), Expect = 0.015 Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 22/112 (19%) Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK--------- 461 K + K EK E K EVK P + KK + ++V KE++ +K+ KK Sbjct: 686 KEIKKEEKKEPKKEVKKETPPKEVKKEV--KKEEKKEVKKEEKEPKKEIKKLPKDAKKSS 743 Query: 462 ---------AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504 A +K KV ++EE +++ + K K++GK K IK+E + E Sbjct: 744 TPLSEAKKPAALKPKVPKKEES--VKKDSVAAGKPKEKGKIKVIKKEGKAAE 793 Score = 31.2 bits (69), Expect = 2.5 Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 3/82 (3%) Query: 445 IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS-- 502 + VD E E+ KA K E+ + +K + ++S KK GK K + P Sbjct: 2217 VSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAG 2276 Query: 503 -EEEPCTSTAIASPEKKKKKKK 523 +E + +ASP+KK+ +K Sbjct: 2277 LKESSDKVSRVASPKKKESVEK 2298 >gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] Length = 1316 Score = 50.4 bits (119), Expect = 4e-06 Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 10/92 (10%) Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499 S+KR+ + V+ D EKKA++++ K +EE + +K + KKKK+ K KH + Sbjct: 1159 SRKRRHDSVENSDSHVEKKARRSEQKDPLEEPKAKKHKKS------KKKKKSKDKHRDRD 1212 Query: 500 PLSEEEPCTSTAIASPE----KKKKKKKKREN 527 +++ S A + + KKKKKKKKR + Sbjct: 1213 SRHQQDSDLSAACSDADLHRHKKKKKKKKRHS 1244 Score = 29.3 bits (64), Expect = 9.3 Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 7/52 (13%) Query: 478 EEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 E ++ V+KK +R ++K EEP +++ +KKKK K K + D Sbjct: 1168 ENSDSHVEKKARRSEQKDPLEEPKAKKHK-------KSKKKKKSKDKHRDRD 1212 >gi|56676397 ankyrin repeat domain 11 [Homo sapiens] Length = 2663 Score = 48.5 bits (114), Expect = 1e-05 Identities = 50/192 (26%), Positives = 90/192 (46%), Gaps = 24/192 (12%) Query: 349 QTSPKHKGK------ISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLE-DR 401 +T KHK K IS+ L K+ Y+ + S A+ +EN E +L+ L+ DR Sbjct: 633 KTKHKHKNKEKGQCSISQELKLKS-FTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDR 691 Query: 402 G-IRKISGTGKALAKTEKY---EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457 +K K + +++ + KS + D + D + +K + + +KE + EK Sbjct: 692 DHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEK 751 Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 K+ K+++ EE +++ S + K KK +KE+ +S+E+ I +K Sbjct: 752 SPKEEKLRLYKEERKKK--------SKDRPSKLEKKNDLKEDKISKEKE----KIFKEDK 799 Query: 518 KKKKKKKRENED 529 +K KK+K ED Sbjct: 800 EKLKKEKVYRED 811 Score = 38.9 bits (89), Expect = 0.012 Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 12/94 (12%) Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK-------KAKKAK 463 K K E+Y+ KS K D S S L C K ++ ++ KE + T++ K K+ K Sbjct: 1020 KEKTKPERYKEKSSDK--DKSEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERK 1077 Query: 464 IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKK 494 + +E++EK E+ S KK K+GK+K Sbjct: 1078 ASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEK 1111 Score = 35.8 bits (81), Expect = 0.099 Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 11/113 (9%) Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473 AK EK E K + + Y G ++ Q +K+ + +K +E+E + Sbjct: 1366 AKKEKAEKKEKGEDYKEGGS--------RKDSGQYEKDFLEADAYGVSYNMKADIEDELD 1417 Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 + + E S +KK K ++ ++ E +P S+AI ++KKK++K RE Sbjct: 1418 KTI---ELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKREKHRE 1467 Score = 33.9 bits (76), Expect = 0.38 Identities = 20/81 (24%), Positives = 39/81 (48%), Gaps = 1/81 (1%) Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCT 508 D++D + + K K K+ E+ E+K A E++ K K+K K+H KE S Sbjct: 1219 DRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEK-SDKEHSKERKSSRSADAE 1277 Query: 509 STAIASPEKKKKKKKKRENED 529 + + E++ + + ++ D Sbjct: 1278 KSLLEKLEEEALHEYREDSND 1298 Score = 30.4 bits (67), Expect = 4.2 Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Query: 449 DKEDEITEK-KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK---RGKKKHIKEEPLSEE 504 DK++++ EK K KK K + ++ +++ + + K K+K + +KKH E+ + Sbjct: 1196 DKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSK 1255 Query: 505 EPCTSTAIASPEKKKKKKKKRE 526 S S E+K + E Sbjct: 1256 HKEKSDKEHSKERKSSRSADAE 1277 Score = 30.4 bits (67), Expect = 4.2 Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 32/142 (22%) Query: 416 TEKYEHKSEVKTYDPSGDST----LPTCSKKRKI----------EQVDKEDEITEKKAKK 461 TEKY+ + + + D + D LP ++K+ E+ DKE K ++ Sbjct: 1214 TEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRS 1273 Query: 462 AKI-KVKVEEEEEEKVAEEEETSVKKKKK--------RGKKKHIK-------EEPLSEEE 505 A K +E+ EEE + E E S K + RG++ + EP +++ Sbjct: 1274 ADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDK 1333 Query: 506 PCTSTAIASPEKKKKKKKKREN 527 P S + PEK K+K++ R + Sbjct: 1334 PRESACL--PEKLKEKERHRHS 1353 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 48.5 bits (114), Expect = 1e-05 Identities = 40/144 (27%), Positives = 73/144 (50%), Gaps = 7/144 (4%) Query: 384 GVENRAKLEARLRTLEDRGIR-KIS-GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441 G ++++K + R E+ ++ K++ TG A EK E + + D GD K Sbjct: 262 GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED-DNEGDKK----KK 316 Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501 +K ++ +KE++ EKK +K VK +E K+ EEEE +++++R K+ E Sbjct: 317 DKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKR 376 Query: 502 SEEEPCTSTAIASPEKKKKKKKKR 525 EEE ++K+K++K+R Sbjct: 377 KEEERLEQEKRERKKQKEKERKER 400 Score = 42.0 bits (97), Expect = 0.001 Identities = 43/180 (23%), Positives = 80/180 (44%), Gaps = 41/180 (22%) Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR------ 443 KL + + + +K G+ + ++K + +S + + SGD + ++ Sbjct: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ 204 Query: 444 ------KIEQVDKEDE-------ITEKKAKKAKIKVKVEEEEE---EKVAEEEETSVKKK 487 IE +++D+ + +KKA+K + + K +EE+ K+ E+EE KK Sbjct: 205 KNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264 Query: 488 ---KKRGKKKHIKEE-------------PLSEEEPCTSTAIASP---EKKKKKKKKRENE 528 K++ ++ +EE P SEE+ T TA +KKKK KKK++ E Sbjct: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE 324 Score = 41.2 bits (95), Expect = 0.002 Identities = 37/147 (25%), Positives = 71/147 (48%), Gaps = 6/147 (4%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSE---VKTYDPSGDSTLPTCSKK 442 + R + +A+LR L+++ ++ K +K ++ + K E VK+ +P +K Sbjct: 241 KKRDEEKAKLRKLKEK--EELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK 298 Query: 443 RKIEQVDKEDEITEKKAK-KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPL 501 + ++D +KK K K K K + EE+E+EK + +VK ++ K +EE Sbjct: 299 AETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQ 358 Query: 502 SEEEPCTSTAIASPEKKKKKKKKRENE 528 EE + E K+K++++ E E Sbjct: 359 KREEEERIKRLEELEAKRKEEERLEQE 385 Score = 40.8 bits (94), Expect = 0.003 Identities = 40/161 (24%), Positives = 73/161 (45%), Gaps = 23/161 (14%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436 +D+S + + K E + R + R K AK K + K E++T Sbjct: 219 DDASFKIKTVAQKKAEKKERERKKRDEEK--------AKLRKLKEKEELETGKKDQ---- 266 Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496 SK+++ ++ +E+ + K + EE+ E A E++ KKKK KKK Sbjct: 267 ---SKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323 Query: 497 KEEPLSEEE---PCTSTAIASPE-----KKKKKKKKRENED 529 ++E +E+ P +T A E K++++++KRE E+ Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364 Score = 40.4 bits (93), Expect = 0.004 Identities = 43/170 (25%), Positives = 74/170 (43%), Gaps = 22/170 (12%) Query: 382 AMGVENRAK--LEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD---PSGDSTL 436 A GVE +K L + ED+ +KI ++ +E E + V+ + P + T Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487 Query: 437 PTCSKKRKIEQVDK---------EDEITEK-KAKKAKIKVKV-------EEEEEEKVAEE 479 P + + + D DE TEK + K I+VK EEEEEE+ E Sbjct: 488 PPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES 547 Query: 480 EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 EE ++ + G + ++E +S+E+ T P K+ + +++D Sbjct: 548 EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597 Score = 36.2 bits (82), Expect = 0.076 Identities = 25/96 (26%), Positives = 53/96 (55%), Gaps = 6/96 (6%) Query: 408 GTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIK-- 465 G K K +K K E + G S + + + ++ KE+E +K+ ++ +IK Sbjct: 311 GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKL-KEEEERQKREEEERIKRL 369 Query: 466 --VKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499 ++ + +EEE++ E+E+ KK+K++ +K+ +K+E Sbjct: 370 EELEAKRKEEERL-EQEKRERKKQKEKERKERLKKE 404 Score = 33.5 bits (75), Expect = 0.49 Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 11/116 (9%) Query: 422 KSEVKTYDPSGD----STLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA 477 K +V+ Y S D + LP +K + + K D E + KIK + + Sbjct: 128 KPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESG 187 Query: 478 EEEETSVKKKKKRGKKKHIKEEP-----LSEEEPCTSTAIASPEKKKKKKKKRENE 528 +E + ++ +K G+KK+ K +P E+ S I + +KK +KK+RE + Sbjct: 188 DESDEFLQSRK--GQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241 Score = 33.5 bits (75), Expect = 0.49 Identities = 17/82 (20%), Positives = 45/82 (54%) Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 E+ ++++E E++ ++ + + +EE+EKV++E+++ KK K+ E S+++ Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598 Query: 506 PCTSTAIASPEKKKKKKKKREN 527 K++ +K++ E+ Sbjct: 599 RTKEERAYDKAKRRIEKRRLEH 620 Score = 31.2 bits (69), Expect = 2.5 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 14/100 (14%) Query: 441 KKRKIEQVDKEDEITEK-----------KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK 489 KK K +Q ED+I ++ KA + + VK E EE+ +++ KKK + Sbjct: 45 KKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDK---KKKGQ 101 Query: 490 RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 +GKK+ + E E S + + + K + +++D Sbjct: 102 KGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 48.1 bits (113), Expect = 2e-05 Identities = 37/147 (25%), Positives = 61/147 (41%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436 E++ S ++ K EA+ +++ + T + K E KS K P TL Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759 Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496 S + K ++ +K +KAK VK E + EK + K +K KK Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819 Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKK 523 + P+ EEE + P KK +++K Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEK 846 Score = 42.7 bits (99), Expect = 8e-04 Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 20/109 (18%) Query: 430 PSGDSTLPTCS---------KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE- 479 P G +P+ S K + +E+ +KE I E++ ++ ++ +V EEEE++ EE Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEE 482 Query: 480 --EETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 EE ++++ G ++ K P E ASPEK+ K K E Sbjct: 483 GKEEEGGEEEEAEGGEEETKSPPAEE--------AASPEKEAKSPVKEE 523 Score = 42.0 bits (97), Expect = 0.001 Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 6/140 (4%) Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449 K A +T E + +K K K + E K +P+ + + + +K E D Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKK------EPAVEKPKESKVEAKKEEAED 899 Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509 K+ T +K AK++VK + + +EK ++ K K K K+E E++ Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959 Query: 510 TAIASPEKKKKKKKKRENED 529 PE+K K + K + +D Sbjct: 960 EKAKKPEEKPKTEAKAKEDD 979 Score = 40.4 bits (93), Expect = 0.004 Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 2/147 (1%) Query: 385 VENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRK 444 V++ K E + + ++ + K + KA A + E K K P ++ P +K++ Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879 Query: 445 IEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVA--EEEETSVKKKKKRGKKKHIKEEPLS 502 ++ E K ++A+ K KV E+E A E +E + K+K KK + Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939 Query: 503 EEEPCTSTAIASPEKKKKKKKKRENED 529 E A+PEKK K++K + + Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPE 966 Score = 40.0 bits (92), Expect = 0.005 Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 7/107 (6%) Query: 418 KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEE---EEE 474 K + + ++K + S T+ + + E+ +E+TE++ K+AK + EEE EEE Sbjct: 437 KVKSEEKIKVVEKSEKETVIV---EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEE 493 Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521 EEET ++ + + P+ EE + A SPEK++ K Sbjct: 494 AEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEA-KSPEKEEAK 539 Score = 39.7 bits (91), Expect = 0.007 Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 2/109 (1%) Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV-KVEEEEEEKVAE 478 E K E K + +PT K+ + KED ++K + AK + + +E K AE Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946 Query: 479 EEETSVKKK-KKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 ++E + +KK K K K +E+P +E + S E K K +K E Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995 Score = 38.1 bits (87), Expect = 0.020 Identities = 36/152 (23%), Positives = 68/152 (44%), Gaps = 13/152 (8%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGK-ALAKTE-----KYEHKSEVKTYDP 430 E A+ +K+EA+ ED+ +K+ K A AK E K + K+EV +P Sbjct: 876 EKKEPAVEKPKESKVEAKKEEAEDK--KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEP 933 Query: 431 SGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKR 490 K E ++ + E+KAKK + K K E + A+E++ ++ K+ + Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK-----AKEDDKTLSKEPSK 988 Query: 491 GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522 K + ++ ++++ A+ +K K K Sbjct: 989 PKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020 Score = 37.4 bits (85), Expect = 0.034 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 10/116 (8%) Query: 418 KYEHKSEVKTYDP-SGDSTLPT--CSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474 K E KS K P D+ P KK +++ KE+E K ++ K+K ++ EEE Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE----KPQEVKVKEPPKKAEEE 845 Query: 475 KVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKK--KKKKKRENE 528 K +T KK K+ + KE P + E A+ P++ K KK++ E++ Sbjct: 846 KAPATPKTEEKKDSKKEEAPK-KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900 Score = 35.8 bits (81), Expect = 0.099 Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 9/127 (7%) Query: 411 KALAKTEKYEHKSEVKTYD---PSGDSTLPTCSKKRKIEQVDKEDEITEKK-----AKKA 462 K AK E+ E K +V T + P+ K K E KE + + K A+K Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948 Query: 463 KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522 + + ++ +EEK + EE + K + K + +EP S+ + + +S ++K K Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP-SKPKAEKAEKSSSTDQKDSKP 1007 Query: 523 KKRENED 529 ++ ED Sbjct: 1008 PEKATED 1014 Score = 33.9 bits (76), Expect = 0.38 Identities = 42/163 (25%), Positives = 64/163 (39%), Gaps = 20/163 (12%) Query: 376 GEDSSSAMGVENRAKL----EARLRTLEDRGIRKISGTGKALAKT-EKYEHKSEVKTYDP 430 G + A G E K EA E + K A AK+ EK E KS + P Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547 Query: 431 SG-------DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETS 483 ++ P +K + E+ E+ + K+ K + + E K E+ ++ Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607 Query: 484 VKKKKKRGK--KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524 VK++ K K +KEE S E + SPEK K K+ Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAE------VKSPEKAKSPTKE 644 Score = 33.9 bits (76), Expect = 0.38 Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 14/153 (9%) Query: 385 VENRAKLEARLRTLED-RGIRKISGTGKALAKT-EKYEHKSEVKTYDP-SGDSTLPTCSK 441 V+ AK A +++ E + K AK+ EK E KS K P ++ P +K Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681 Query: 442 ---KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKH--I 496 K + + +K +++AK + K K +EE K E+ ++ VK++ K +K + Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPE-KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740 Query: 497 KEEPLSEE-----EPCTSTAIASPEKKKKKKKK 524 KEE S E E + + SPE K K++ Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773 Score = 32.0 bits (71), Expect = 1.4 Identities = 35/156 (22%), Positives = 63/156 (40%), Gaps = 27/156 (17%) Query: 373 DAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSG 432 D F E + S + E ++ +A+ ED A A ++ K EVK+ Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKED-----------AKAPEKEIPKKEEVKS----- 822 Query: 433 DSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492 ++ K ++V ++ + + +KA K EE+++ K E + K K K Sbjct: 823 -----PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877 Query: 493 KKHIKEEP------LSEEEPCTSTAIASPEKKKKKK 522 K+ E+P +EE + +PEK+ K Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913 Score = 31.6 bits (70), Expect = 1.9 Identities = 38/147 (25%), Positives = 53/147 (36%), Gaps = 21/147 (14%) Query: 399 EDRGIRKISGTGKALAKTE---KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT 455 E + K KA AK+ K K+E K+ + + K + KE+ + Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718 Query: 456 EKKAK-----------KAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE 504 +KAK KAK VK E + EK E+ K K KEE S Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778 Query: 505 EPCTSTA-------IASPEKKKKKKKK 524 + A + SPEK K K+ Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLKE 805 Score = 31.2 bits (69), Expect = 2.5 Identities = 28/121 (23%), Positives = 49/121 (40%), Gaps = 9/121 (7%) Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK-----KAKIKVK 467 + + E+ E K E + G+ ++ +E EK+AK +AK + Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE 529 Query: 468 VEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE----EEPCTSTAIASPEKKKKKKK 523 + E+E+ E +K K K+ K P ++ EE + + SPEK K K Sbjct: 530 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589 Query: 524 K 524 + Sbjct: 590 E 590 Score = 30.8 bits (68), Expect = 3.2 Identities = 34/151 (22%), Positives = 58/151 (38%), Gaps = 9/151 (5%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436 E++ S ++ K EA+ E + K K AK+ E + + Sbjct: 522 EEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580 Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK--VAEEEETSVKKKKKRGKKK 494 P +K E+ E + K+ +K + + E K V EE ++ + K K Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640 Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525 KEE S E+ SPEK++ K ++ Sbjct: 641 PTKEEAKSPEKA------KSPEKEEAKSPEK 665 Score = 29.3 bits (64), Expect = 9.3 Identities = 27/151 (17%), Positives = 63/151 (41%), Gaps = 8/151 (5%) Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKR 443 G+ + ++ + I+ + + K E+ +++V T + + + ++ Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEG 483 Query: 444 KIEQVDKEDEIT--EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK---- 497 K E+ +E+E E++ K + E+E K +EE + K +K+ K Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543 Query: 498 -EEPLSEEEPCTSTAIASPEKKKKKKKKREN 527 + P + P A + PE K +K++ ++ Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574 >gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] Length = 245 Score = 46.6 bits (109), Expect = 6e-05 Identities = 36/141 (25%), Positives = 66/141 (46%), Gaps = 21/141 (14%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 E K + + + ++RG G + + K E + E ++RK Sbjct: 108 EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE----------------RERKK 151 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 E+ +KE E E+K ++ K +V E+EEE+ +E+E +KK++R +K+ KE E Sbjct: 152 EEREKERERKERKKRERK---QVGEKEEER--KEKERKERKKRERNRKERKKERERKERR 206 Query: 506 PCTSTAIASPEKKKKKKKKRE 526 E+KK+++K R+ Sbjct: 207 ERKKERKKKEERKKERQKDRQ 227 Score = 45.8 bits (107), Expect = 1e-04 Identities = 34/144 (23%), Positives = 68/144 (47%), Gaps = 3/144 (2%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 E + + + R + R K + G+ K +K E K +T S + ++RK Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT---SKEGKERERKEERKR 141 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 E+ + + E++ K+ + K + + E ++ +EEE K++K+R K++ ++E E E Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201 Query: 506 PCTSTAIASPEKKKKKKKKRENED 529 KKK+++KK +D Sbjct: 202 RKERRERKKERKKKEERKKERQKD 225 Score = 45.1 bits (105), Expect = 2e-04 Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 9/121 (7%) Query: 415 KTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEE 474 K K E +SE K + K+RK E+ KE + KK ++ + K + E+E +E Sbjct: 49 KEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKE 108 Query: 475 KVAEEEETSVKKKKKR-------GKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527 EE+E KK+KK GK++ KEE EE EK++++K++++ Sbjct: 109 --GEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKR 166 Query: 528 E 528 E Sbjct: 167 E 167 Score = 39.3 bits (90), Expect = 0.009 Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 12/90 (13%) Query: 441 KKRKIE---QVDKEDEITEKKAKKAKIKVKVEEEEEEKV--AEEEETSVKKKKKRGKKKH 495 ++R+IE + KE E KK ++ + K K E E+E K ++E+ +KK++R +KK Sbjct: 41 REREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKR 100 Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525 +E+ E E ++KKK+KK+R Sbjct: 101 RREKENKEGEE-------KEKRKKKEKKER 123 Score = 37.4 bits (85), Expect = 0.034 Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 4/85 (4%) Query: 444 KIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK----KKKKRGKKKHIKEE 499 +I + ++E E ++ K+ + + K E E EK E E K KK+K+G++K + E Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96 Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524 + EK+KKK+KK Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKK 121 Score = 36.6 bits (83), Expect = 0.058 Identities = 22/83 (26%), Positives = 44/83 (53%), Gaps = 3/83 (3%) Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK---HIKEEPLSEEE 505 ++E EI +K K + + + ++E E+ + E ++K++RGKK+ K+E ++ Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99 Query: 506 PCTSTAIASPEKKKKKKKKRENE 528 E+K+K+KKK + E Sbjct: 100 RRREKENKEGEEKEKRKKKEKKE 122 Score = 34.3 bits (77), Expect = 0.29 Identities = 18/75 (24%), Positives = 44/75 (58%), Gaps = 4/75 (5%) Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514 +E + ++ +I+ + E ++E + ++E ++K+KR ++K K E +E+ Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK----KGERK 91 Query: 515 PEKKKKKKKKRENED 529 E++++KK++RE E+ Sbjct: 92 KEERERKKRRREKEN 106 Score = 29.3 bits (64), Expect = 9.3 Identities = 24/105 (22%), Positives = 47/105 (44%) Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447 R + + R R E+R + K + + E + E K + K+RK E+ Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200 Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492 KE +K+ KK + + K +++ + E+E +++K+R K Sbjct: 201 ERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245 >gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] Length = 793 Score = 46.2 bits (108), Expect = 7e-05 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 16/162 (9%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436 E+ A R K E + R E+R ++I K A+ E+ K E K Sbjct: 319 EEEKRAAEERQRIKEEEK-RAAEER--QRIKEEEKRAAE-ERQRIKEEEKRAAEERQRAR 374 Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE--------EKVAEEEETSVKKKK 488 +K K+E+ + ++ EKK + K+K E+ E+ EK A+E++ K Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434 Query: 489 KRGKKK----HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 K+G++K K E L E++P EK KK K+ +E Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476 Score = 40.8 bits (94), Expect = 0.003 Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 4/116 (3%) Query: 411 KALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEE 470 K+ ++ E+YE + E +T S +++ K E +KE+E EK + + + +VE Sbjct: 152 KSESRQERYEIE-ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEV 210 Query: 471 EEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE-PCTSTAIASPEKKKKKKKKR 525 EEK E +E +V K G+ EEP EEE S I+ EK +++ K+R Sbjct: 211 MVEEKTTESQEETVVMSLKNGQIS--SEEPKQEEEREQGSDEISHHEKMEEEDKER 264 Score = 40.0 bits (92), Expect = 0.005 Identities = 28/146 (19%), Positives = 64/146 (43%), Gaps = 11/146 (7%) Query: 383 MGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKK 442 M E++ + EA LE +I E+ ++E K +++ Sbjct: 257 MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA-----------AAQE 305 Query: 443 RKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLS 502 R+ + ++ + + E++ + A+ + +++EEE+ E + ++K+ +++ IKEE Sbjct: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365 Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528 E EK K +++KR + Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQ 391 Score = 37.7 bits (86), Expect = 0.026 Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 10/155 (6%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTL 436 E+ A R K E + R E+R + KA + +K + E K + + Sbjct: 347 EEEKRAAEERQRIKEEEK-RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH-----AMQ 400 Query: 437 PTCSKKRKIEQVDKEDEITEKKAKKAKIK---VKVEEEEEEKVAEEEETSVKKKKKRGKK 493 T K K+EQ + + EKKA++ K++ +K + EE+ + + +++ K KK Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460 Query: 494 KHIKEEPL-SEEEPCTSTAIASPEKKKKKKKKREN 527 + IK+E + ++EP KK + K +N Sbjct: 461 EEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495 Score = 35.8 bits (81), Expect = 0.099 Identities = 20/90 (22%), Positives = 46/90 (51%) Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499 S K+E+ DKE E+ +A+ + +++ E+++K+A+E ++K +++ +E Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311 Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENED 529 E A ++ K+++KR E+ Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEE 341 Score = 35.0 bits (79), Expect = 0.17 Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 3/82 (3%) Query: 426 KTYDPS-GDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV 484 K +DP+ D++L S R+++ E+E TEK+ K + + E EE E V + + + Sbjct: 119 KEFDPTITDASLSLPS--RRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND 176 Query: 485 KKKKKRGKKKHIKEEPLSEEEP 506 + + KK+ ++E EE+P Sbjct: 177 WRDAEENKKEDKEKEEEEEEKP 198 Score = 33.9 bits (76), Expect = 0.38 Identities = 33/165 (20%), Positives = 77/165 (46%), Gaps = 21/165 (12%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKTYDPSGDSTLPTCSKKR 443 + RA++EA + R+ + + + + EK E + +K + ++ Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349 Query: 444 KI-----EQVDKEDEITEKKAKKAKI----KVKVEEEEEEKVAEEEETSVKKKKKRGKK- 493 K +++ +E++ ++ ++A+ K KVEE++ K EE++ ++++ K +G+K Sbjct: 350 KRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409 Query: 494 ------KHIKEEPLSEEEPCTSTAIASPEKKKKK---KKKRENED 529 K + E+ E++ T+ E+K K K+++ ED Sbjct: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQED 454 Score = 33.1 bits (74), Expect = 0.64 Identities = 24/92 (26%), Positives = 49/92 (53%), Gaps = 4/92 (4%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKV---KVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497 ++R+ E +E E ++K ++A +++ K + EE KV EEEE +K+++ +K + Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR-RKQEEADRKLREE 598 Query: 498 EEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 EE +E + EK++K + ++D Sbjct: 599 EEKRRLKEEIERRRAEAAEKRQKMPEDGLSDD 630 Score = 32.3 bits (72), Expect = 1.1 Identities = 25/114 (21%), Positives = 57/114 (50%), Gaps = 6/114 (5%) Query: 416 TEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEK 475 T K +H +E P G +++ T + QV+ + E + ++ + E EE EK Sbjct: 500 THKLKH-TENTFSRPGGRASVDT-KEAEGAPQVEAGKRLEELRRRRGE----TESEEFEK 553 Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 + ++++ + + ++ KK+ + + L EEE A + +++++K+R E+ Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607 Score = 31.2 bits (69), Expect = 2.5 Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 10/119 (8%) Query: 393 ARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDST------LPTCSKKRKIE 446 A + T E G ++ GK L + + ++E + ++ L KKR+ Sbjct: 517 ASVDTKEAEGAPQVEA-GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575 Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 + E+E +K ++A K++ EEEEK +EE ++ + K++ + E+ LS+++ Sbjct: 576 RKVLEEEEQRRKQEEADRKLR---EEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631 Score = 29.6 bits (65), Expect = 7.1 Identities = 22/111 (19%), Positives = 53/111 (47%), Gaps = 4/111 (3%) Query: 420 EHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV----KVEEEEEEK 475 E++ EV + + +S T K Q+ E+ E++ ++ ++ K+EEE++E+ Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKER 264 Query: 476 VAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 E ++++R K + K+ A+ E+++++ ++RE Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315 >gi|239750213 PREDICTED: hypothetical protein [Homo sapiens] Length = 248 Score = 45.8 bits (107), Expect = 1e-04 Identities = 25/86 (29%), Positives = 46/86 (53%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500 +K+K + K+ + T KK KK K K + +++ ++T+ K++ K+K ++E Sbjct: 27 RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86 Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526 E+E +KKKKKKKK++ Sbjct: 87 EKEKEKEKEKEKKKKKKKKKKKKKKK 112 Score = 45.1 bits (105), Expect = 2e-04 Identities = 26/80 (32%), Positives = 42/80 (52%) Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476 +K + K+ +K + T K++ K T K+ +K K K K +E+E+EK Sbjct: 34 KKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKE 93 Query: 477 AEEEETSVKKKKKRGKKKHI 496 E+E+ KKKKK+ KKK + Sbjct: 94 KEKEKKKKKKKKKKKKKKKL 113 Score = 41.6 bits (96), Expect = 0.002 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 1/88 (1%) Query: 410 GKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVE 469 G+ T+K + K + T +K +K K+ T K K+ K K K + Sbjct: 26 GRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE-KEKEKEK 84 Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIK 497 E+E+EK E+E+ KKKKK+ KKK K Sbjct: 85 EKEKEKEKEKEKEKKKKKKKKKKKKKKK 112 Score = 41.2 bits (95), Expect = 0.002 Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 7/111 (6%) Query: 417 EKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKV 476 EK +E ++ G T KK+K + K+ + T KK K K + ++ Sbjct: 11 EKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTT 70 Query: 477 AEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKREN 527 +E +K+K++ K+K ++E E++ +KKKKKKKK+ N Sbjct: 71 TTTKEKEKEKEKEKEKEKEKEKEKEKEKK-------KKKKKKKKKKKKKLN 114 Score = 39.3 bits (90), Expect = 0.009 Identities = 24/71 (33%), Positives = 38/71 (53%), Gaps = 1/71 (1%) Query: 438 TCSKKRKIEQVDKEDEITEKKAKKA-KIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496 T +KK+ + K T+K K K K +E+E+EK E+E+ K+KKK+ KKK Sbjct: 48 TTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEKEKEKEKEKEKEKKKKKKKKKK 107 Query: 497 KEEPLSEEEPC 507 K++ + C Sbjct: 108 KKKKKLNAKVC 118 Score = 37.7 bits (86), Expect = 0.026 Identities = 25/90 (27%), Positives = 42/90 (46%) Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAK 463 RK T K K + K + T + T + +K +++ EK+ +K K Sbjct: 27 RKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEKEK 86 Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKK 493 K K +E+E+EK ++++ KKKKK K Sbjct: 87 EKEKEKEKEKEKKKKKKKKKKKKKKKLNAK 116 Score = 36.2 bits (82), Expect = 0.076 Identities = 25/86 (29%), Positives = 48/86 (55%), Gaps = 9/86 (10%) Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI-----KEEPLS 502 ++K ITEK++ + + K ++++K ++T++KKKKK KK K + Sbjct: 10 MEKVHVITEKESAWKRGRKKKTTKKKKK----KKTTMKKKKKTTTKKKTTTKTKKRTTTT 65 Query: 503 EEEPCTSTAIASPEKKKKKKKKRENE 528 ++ T+T EK+K+K+K++E E Sbjct: 66 KKTTTTTTKEKEKEKEKEKEKEKEKE 91 Score = 35.4 bits (80), Expect = 0.13 Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 12/85 (14%) Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEE----------- 504 +K K+ V E+E K +++T+ KKKKK+ K K+ ++ Sbjct: 5 DKGVAMEKVHVITEKESAWKRGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTT 64 Query: 505 -EPCTSTAIASPEKKKKKKKKRENE 528 + T+T EK+K+K+K++E E Sbjct: 65 TKKTTTTTTKEKEKEKEKEKEKEKE 89 Score = 33.5 bits (75), Expect = 0.49 Identities = 27/93 (29%), Positives = 46/93 (49%), Gaps = 2/93 (2%) Query: 401 RGIRKISGTGKALAKTE-KYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA 459 RG +K + K KT K + K+ K + T +KK ++++ EK+ Sbjct: 25 RGRKKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKEKEKEKEK 84 Query: 460 KKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492 +K K K K E+E+E+K ++++ KKKK K Sbjct: 85 EKEKEKEK-EKEKEKKKKKKKKKKKKKKKLNAK 116 Score = 30.4 bits (67), Expect = 4.2 Identities = 18/74 (24%), Positives = 37/74 (50%), Gaps = 8/74 (10%) Query: 456 EKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASP 515 +KK K K K K ++++K +++T+ K KK+ K E+E Sbjct: 28 KKKTTKKKKKKKTTMKKKKKTTTKKKTTTKTKKRTTTTKKTTTTTTKEKE--------KE 79 Query: 516 EKKKKKKKKRENED 529 ++K+K+K+K + ++ Sbjct: 80 KEKEKEKEKEKEKE 93 >gi|11225260 DNA topoisomerase I [Homo sapiens] Length = 765 Score = 45.4 bits (106), Expect = 1e-04 Identities = 38/148 (25%), Positives = 66/148 (44%), Gaps = 21/148 (14%) Query: 384 GVENRAKLEARLRTLEDRGIRKISGTGKALAKTEK---YEHKSEVKTYDPSGDSTLPTCS 440 G + K + + R E R K+ +G A K EK + ++K +P D Sbjct: 72 GSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKD-EPEDDGYFVPPK 130 Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500 + K + ++++ + K KK K + ++E++ K+ EEE+ +KK K + K K + E Sbjct: 131 EDIKPLKRPRDEDDADYKPKKIKTE-DTKKEKKRKLEEEEDGKLKKPKNKDKDKKVPE-- 187 Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528 P+ KKKK KK E + Sbjct: 188 --------------PDNKKKKPKKEEEQ 201 Score = 37.7 bits (86), Expect = 0.026 Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 10/120 (8%) Query: 415 KTEKYEHKSEVKTYDPS----GDSTLPTCSKKRKIEQVDK-EDEITEKKAKKAKIKVKVE 469 K ++ HK K D +S KK K ++ K +D +EK K K + K E Sbjct: 29 KDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDK-E 87 Query: 470 EEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED 529 + +EEKV + +KK+K+ G P ++EP P++ K K+ +ED Sbjct: 88 KRKEEKVRASGDAKIKKEKENG----FSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDED 143 Score = 30.0 bits (66), Expect = 5.5 Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 6/89 (6%) Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEE----EEKVAEEEETSVKKKKKRGKKKH 495 S K K + D+E E K +K + K K E E+K E+E+T K K +K Sbjct: 21 SHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKT--KHKDGSSEKHK 78 Query: 496 IKEEPLSEEEPCTSTAIASPEKKKKKKKK 524 K + +E+ AS + K KK+K+ Sbjct: 79 DKHKDRDKEKRKEEKVRASGDAKIKKEKE 107 Score = 29.6 bits (65), Expect = 7.1 Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 9/84 (10%) Query: 447 QVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSV--KKKKKRGKKKHIKEEPLSEE 504 Q++ + + + K K K + +E K ++ E S + K +KKH ++E + Sbjct: 11 QIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEKTKHK 70 Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528 + S EK K K K R+ E Sbjct: 71 D-------GSSEKHKDKHKDRDKE 87 >gi|46276863 parathymosin [Homo sapiens] Length = 102 Score = 45.4 bits (106), Expect = 1e-04 Identities = 25/80 (31%), Positives = 46/80 (57%), Gaps = 1/80 (1%) Query: 449 DKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK-KKKKRGKKKHIKEEPLSEEEPC 507 +K++++ EK ++K + K VEEEE EEEET+ +++ G+++ +EE +E P Sbjct: 19 EKKEKVEEKASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGEEEDEEEEEEDDEGPA 78 Query: 508 TSTAIASPEKKKKKKKKREN 527 A ++ K++K EN Sbjct: 79 LKRAAEEEDEADPKRQKTEN 98 Score = 30.0 bits (66), Expect = 5.5 Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 6/68 (8%) Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKK 521 A++ K +E++EKV E K +K KK+ ++EE EE TA E+ + + Sbjct: 10 AELSAKDLKEKKEKVEE------KASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGE 63 Query: 522 KKKRENED 529 ++ E E+ Sbjct: 64 EEDEEEEE 71 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 15/130 (11%) Query: 413 LAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKA---------KKAK 463 L K E ++ K+E + T T +K K ++ +E E EKKA +K + Sbjct: 138 LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPE 197 Query: 464 IKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKK 523 K +E+++ K AE+ E KK+ K GK++ +K+ +E + P++K+ K+K Sbjct: 198 TKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKE--VQKTPSKPKEKEDKEK 255 Query: 524 ----KRENED 529 K E +D Sbjct: 256 AAVSKHEQKD 265 Score = 38.1 bits (87), Expect = 0.020 Identities = 44/191 (23%), Positives = 81/191 (42%), Gaps = 14/191 (7%) Query: 346 LVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRK 405 + +T K K I + +T + + G+ S + G K+ A+ +D ++ Sbjct: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGT---VKIAAQAAAKKDEK-KE 378 Query: 406 ISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKK---- 461 S K A+ E+ + K + K + P KK DK+ + ++AK+ Sbjct: 379 DSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSP---KKEHSVPSDKQVKAKTERAKEEIGA 435 Query: 462 AKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLS--EEEPCTSTAIASPEKK 518 IK V ++EEK + E ++K+K +K+ EP+ EE+ S PE K Sbjct: 436 VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETK 495 Query: 519 KKKKKKRENED 529 K +K + ++ Sbjct: 496 KDEKMSKAGKE 506 Score = 35.4 bits (80), Expect = 0.13 Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 4/103 (3%) Query: 430 PSGDSTLPT--CSKKRKIEQVDKEDEITEKKA-KKAKIKVKVEEEEEEKVAEEEETSVK- 485 P+ LPT S+ +E E +KKA KK + K +E+E+ K E+ET++ Sbjct: 288 PAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347 Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528 +KK+ GK K+ + + E KK KK E E Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVE 390 Score = 35.0 bits (79), Expect = 0.17 Identities = 31/94 (32%), Positives = 48/94 (51%), Gaps = 13/94 (13%) Query: 446 EQVDKEDEITEKKAKKAKI-KVKVEEEEE----------EKVAEEEETSVKKKKKRGKKK 494 E DK EI E +K +I K K E++E+ K E+ + V++K+K KK Sbjct: 126 EDTDK-GEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKA 184 Query: 495 HIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528 KE+ +E+P T T +A +KK K +K E + Sbjct: 185 THKEKIEKKEKPETKT-LAKEQKKAKTAEKSEEK 217 Score = 35.0 bits (79), Expect = 0.17 Identities = 25/86 (29%), Positives = 44/86 (51%), Gaps = 1/86 (1%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500 KK E KE E +KK++K + + VE++E K +E ++ +VK + KK K+E Sbjct: 321 KKVTSETKKKEKEDIKKKSEK-ETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKED 379 Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRE 526 + + +K++KK+K E Sbjct: 380 SKKTKKPAEVEQPKGKKQEKKEKHVE 405 Score = 34.3 bits (77), Expect = 0.29 Identities = 30/114 (26%), Positives = 58/114 (50%), Gaps = 12/114 (10%) Query: 386 ENRAKLEARLRTL-----EDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCS 440 E + K E +++T +++G K+ K +K HK +++ + TL Sbjct: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKP---EKKATHKEKIEKKEKPETKTL--AK 203 Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKK 494 +++K + +K +E T+K+ K K + KV ++ KV E ++T K K+K K+K Sbjct: 204 EQKKAKTAEKSEEKTKKEVKGGK-QEKV-KQTAAKVKEVQKTPSKPKEKEDKEK 255 Score = 33.1 bits (74), Expect = 0.64 Identities = 31/125 (24%), Positives = 54/125 (43%), Gaps = 7/125 (5%) Query: 412 ALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ-VDKEDEITEKKAKKAKIKVKVEE 470 AL + E + K+E K + KK + E +D E + K ++ + VK+ Sbjct: 308 ALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAA 367 Query: 471 EEEEKVAEEEETSVKKKKK------RGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKK 524 + K E++E S K KK +GKK+ KE+ + + +K+ K K + Sbjct: 368 QAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTE 427 Query: 525 RENED 529 R E+ Sbjct: 428 RAKEE 432 Score = 31.6 bits (70), Expect = 1.9 Identities = 32/132 (24%), Positives = 62/132 (46%), Gaps = 9/132 (6%) Query: 398 LEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEK 457 LE++ K K ++T+K E K ++K + +K++ + + + T K Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKE-KEDIKK---KSEKETAIDVEKKEPGKASETKQGTVK 364 Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKK-KHIKEEPLSEEEPCTSTAIASPE 516 A +A K ++E+ +K + E K KK+ KK KH+ EP + P ++ S + Sbjct: 365 IAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHV--EP--AKSPKKEHSVPSDK 420 Query: 517 KKKKKKKKRENE 528 + K K ++ + E Sbjct: 421 QVKAKTERAKEE 432 Score = 31.2 bits (69), Expect = 2.5 Identities = 31/135 (22%), Positives = 60/135 (44%), Gaps = 14/135 (10%) Query: 390 KLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVD 449 K E +T+E ++ SG ++ K +K K + + S P K K+ + Sbjct: 446 KEEKTTKTVEQEIRKEKSGKTSSILK-DKEPIKGKEEKVPASLKEKEPETKKDEKMSKAG 504 Query: 450 KEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTS 509 KE K K +++ K EE+ E ++ +E + ++ +K + K+ +K E + Sbjct: 505 KE-----VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK--------T 551 Query: 510 TAIASPEKKKKKKKK 524 + PE+K K+ K Sbjct: 552 VSHGKPEEKVLKQVK 566 Score = 30.8 bits (68), Expect = 3.2 Identities = 27/108 (25%), Positives = 46/108 (42%), Gaps = 2/108 (1%) Query: 422 KSEVKTYDPSGDSTLPTCSKKRKIEQVD-KEDEITEKKAKKAKIKVKVEEEEEEKVAEEE 480 K E K T+ +K + ++ + +E E K K K K E E ++ Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615 Query: 481 ETSVKKKKKRGKKKHIKEEPLS-EEEPCTSTAIASPEKKKKKKKKREN 527 E S K+ K++ KH++EE +S +E + EK + K E+ Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVED 663 >gi|4503337 dyskerin isoform 1 [Homo sapiens] Length = 514 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/85 (34%), Positives = 42/85 (49%) Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499 +KK + +V K ++ + AK AK K + E E +E + K+KKK K K K Sbjct: 423 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 482 Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524 S EP + + +KKKKKK K Sbjct: 483 LESGAEPGDGDSDTTKKKKKKKKAK 507 Score = 32.3 bits (72), Expect = 1.1 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%) Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473 AKT K + +SE ++ D T P Q+ K+++ KK KKAK +E E Sbjct: 442 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 488 Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499 + + T KKKKK+ K+ + E Sbjct: 489 PGDGDSDTTKKKKKKKKAKEVELVSE 514 Score = 29.3 bits (64), Expect = 9.3 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 8/67 (11%) Query: 459 AKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKK 518 ++ AK +V E + +V E + K+K++ E S+E P + + EKK Sbjct: 420 SESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--------SESESDETPPAAPQLIKKEKK 471 Query: 519 KKKKKKR 525 K KK K+ Sbjct: 472 KSKKDKK 478 >gi|215599015 dyskerin isoform 2 [Homo sapiens] Length = 509 Score = 45.1 bits (105), Expect = 2e-04 Identities = 29/85 (34%), Positives = 42/85 (49%) Query: 440 SKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEE 499 +KK + +V K ++ + AK AK K + E E +E + K+KKK K K K Sbjct: 418 AKKEVVAEVVKAPQVVAEAAKTAKRKRESESESDETPPAAPQLIKKEKKKSKKDKKAKAG 477 Query: 500 PLSEEEPCTSTAIASPEKKKKKKKK 524 S EP + + +KKKKKK K Sbjct: 478 LESGAEPGDGDSDTTKKKKKKKKAK 502 Score = 32.3 bits (72), Expect = 1.1 Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 13/86 (15%) Query: 414 AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEE 473 AKT K + +SE ++ D T P Q+ K+++ KK KKAK +E E Sbjct: 437 AKTAKRKRESESES-----DETPPAAP------QLIKKEKKKSKKDKKAK--AGLESGAE 483 Query: 474 EKVAEEEETSVKKKKKRGKKKHIKEE 499 + + T KKKKK+ K+ + E Sbjct: 484 PGDGDSDTTKKKKKKKKAKEVELVSE 509 Score = 31.6 bits (70), Expect = 1.9 Identities = 27/93 (29%), Positives = 44/93 (47%), Gaps = 16/93 (17%) Query: 441 KKRKIEQ--VDKEDEITE------KKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGK 492 KK I+Q +DK + T+ K+ + AK +V E + +V E + K+K++ Sbjct: 389 KKLMIKQGLLDKHGKPTDSTPATWKQDESAKKEVVAEVVKAPQVVAEAAKTAKRKRE--- 445 Query: 493 KKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKR 525 E S+E P + + EKKK KK K+ Sbjct: 446 -----SESESDETPPAAPQLIKKEKKKSKKDKK 473 >gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] Length = 275 Score = 44.7 bits (104), Expect = 2e-04 Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 8/149 (5%) Query: 388 RAKLEARLRTLEDRGI------RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSK 441 R K E + R +RG ++ K + E+ + K E K + K Sbjct: 58 RGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKK 117 Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK--RGKKKHIKEE 499 K + E+ + + E+K KK + K + +E + EK + E KK+KK R KK+ + Sbjct: 118 KERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177 Query: 500 PLSEEEPCTSTAIASPEKKKKKKKKRENE 528 +E E+KK+++KK+E + Sbjct: 178 ERKKERERKERRERKKERKKERRKKKERK 206 Score = 42.4 bits (98), Expect = 0.001 Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 21/141 (14%) Query: 388 RAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQ 447 R K R R +++ RK GK + K K + + +KRK E+ Sbjct: 50 REKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE--------RRKRKKEK 101 Query: 448 VDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPC 507 +E + ++ +K K K + E E E K E + ++KKKR K++ ++E Sbjct: 102 KKRERKQRGRRERKKK-KERKERERENKQRRERKRKKRRKKKRRKERKREKER------- 153 Query: 508 TSTAIASPEKKKKKKKKRENE 528 E+K+KK+KK E E Sbjct: 154 -----GKRERKRKKRKKEERE 169 Score = 41.6 bits (96), Expect = 0.002 Identities = 28/89 (31%), Positives = 46/89 (51%), Gaps = 13/89 (14%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500 K+RK E+ KE + KK ++ K + + +E E++ E E +K+KK KK+ K+ Sbjct: 52 KERKRERGKKEKK-KRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRG 110 Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENED 529 E KKKK++K+RE E+ Sbjct: 111 RRE------------RKKKKERKEREREN 127 Score = 40.4 bits (93), Expect = 0.004 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 14/143 (9%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 E R K + + + + RK G + K E+ E + E K KKR+ Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENK-------QRRERKRKKRRK 140 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 ++ KE + +++ K+ + + K ++EE EK E KK+++R +++ K+E E Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200 Query: 506 PCTSTAIASPEKKKKKKKKRENE 528 E+KK +K R+ + Sbjct: 201 K-------KKERKKDRKTDRQTD 216 Score = 38.9 bits (89), Expect = 0.012 Identities = 21/74 (28%), Positives = 39/74 (52%) Query: 455 TEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIAS 514 +E+K ++ + + + E E+E+ E + KK+KKR + K + + E+ Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93 Query: 515 PEKKKKKKKKRENE 528 K+KK+KKKRE + Sbjct: 94 RRKRKKEKKKRERK 107 Score = 38.5 bits (88), Expect = 0.015 Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 7/88 (7%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEP 500 +KRK E+ +KE + K +K K K + +E E+ +E E K+++++ ++K KE+ Sbjct: 44 EKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKK 102 Query: 501 LSEEEPCTSTAIASPEKKKKKKKKRENE 528 E + ++KKKK+++E E Sbjct: 103 KRERKQ------RGRRERKKKKERKERE 124 Score = 37.0 bits (84), Expect = 0.045 Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 453 EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKE-EPLSEEEPCTSTA 511 E KK ++ + K K E E+E K E K+KKKR K++ KE E +E Sbjct: 33 ESERKKERREREKRKREREKERK----RERGKKEKKKRKKRERGKERERKRKEREKQRKE 88 Query: 512 IASPEKKKKKKKKRENE 528 E++K+KK+K++ E Sbjct: 89 RREKERRKRKKEKKKRE 105 Score = 33.9 bits (76), Expect = 0.38 Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 14/120 (11%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 E + K E + R E++ R+ + K K + + E K G KKRK Sbjct: 113 ERKKKKERKERERENKQRRE-----RKRKKRRKKKRRKERKREKERGKRERKR--KKRKK 165 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 E+ +K+ E K+ KK E E +E+ ++E +++KK+ +KK K + ++ + Sbjct: 166 EEREKKRERNRKERKK-------ERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218 >gi|4506751 restin isoform a [Homo sapiens] Length = 1427 Score = 44.7 bits (104), Expect = 2e-04 Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 29/223 (13%) Query: 336 PKYGL---IYHASLVG---QTSPKHKGKISRMLAAKTVLAIRYD----AFGEDSSSAMGV 385 PKYGL ++ + +G T K K R + A T +++ + SS A V Sbjct: 267 PKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSV 326 Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKAL-AKTEKYEHKSEVKTY-DPSGDSTLPTCSKKR 443 +R L R RKISGT A EK +H ++ D S Sbjct: 327 SSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVG 386 Query: 444 KIEQV-----DKEDE-ITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIK 497 +IEQ D D+ + E +AK +++ VE + EKV + +K+K + ++ Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446 Query: 498 EEPLSEEEPCTSTAIASP-----------EKKKKKKKKRENED 529 EE +++ + T T + EK K K +RE ED Sbjct: 447 EESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED 489 Score = 30.0 bits (66), Expect = 5.5 Identities = 29/144 (20%), Positives = 59/144 (40%), Gaps = 30/144 (20%) Query: 386 ENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKI 445 + AKL+ L TL++ ++ + E+ E+ T + +K+ Sbjct: 1103 QTNAKLQNELDTLKENNLKNV----------EELNKSKELLTVE------------NQKM 1140 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEE 505 E+ KE E ++ A + ++ +EE K+AEE R + + + L EE Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE--------LGRSRDEVTSHQKLEEER 1192 Query: 506 PCTSTAIASPEKKKKKKKKRENED 529 + + +K++ K K +E+ Sbjct: 1193 SVLNNQLLEMKKRESKFIKDADEE 1216 >gi|87299628 biorientation of chromosomes in cell division 1-like [Homo sapiens] Length = 3051 Score = 44.3 bits (103), Expect = 3e-04 Identities = 50/204 (24%), Positives = 82/204 (40%), Gaps = 26/204 (12%) Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408 QTS +GK + A Y + DS + VE R + A+ + E+R +R+ Sbjct: 454 QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK--EERLLRRQIN 511 Query: 409 TGKALAKTEKYEHKSEVK--------TYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAK 460 K K ++ K++ + D ST K +I++V KE ++ EKK Sbjct: 512 REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA 571 Query: 461 KAKIKVK----VEEEEEEKVAEEEETSVKKK------------KKRGKKKHIKEEPLSEE 504 +K + K VEE ++K EE++ K K K H K EP Sbjct: 572 LSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPA 631 Query: 505 EPCTSTAIASPEKKKKKKKKRENE 528 + + E K + K +RE++ Sbjct: 632 RRLSESLHVVDENKNESKLEREHK 655 Score = 34.3 bits (77), Expect = 0.29 Identities = 24/96 (25%), Positives = 47/96 (48%), Gaps = 11/96 (11%) Query: 441 KKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRG--------- 491 +KR+ + + +E + + K+K +VKV E E ++ A ++ T+ K K++ Sbjct: 896 EKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955 Query: 492 KKKHIKEEPLSEE--EPCTSTAIASPEKKKKKKKKR 525 +K ++++P E EP TA +S +K R Sbjct: 956 RKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991 Score = 31.2 bits (69), Expect = 2.5 Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 18/163 (11%) Query: 377 EDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKY--EHKSEVKT-----YD 429 E S +G + + E ++T D +RK + + EK EHKS + D Sbjct: 796 ERKLSVLGKDGKPVSEYIIKT--DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKD 853 Query: 430 PSGDS----TLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVK 485 G TL S+ ++ D + + K ++ V E+ + + EE+ Sbjct: 854 SLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEV-VHKEKRRTKSLLEEKLVLKS 912 Query: 486 KKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENE 528 K K +GK+ + E L E +T A+ K K+K EN+ Sbjct: 913 KSKTQGKQVKVVETELQE----GATKQATTPKPDKEKNTEEND 951 Score = 30.4 bits (67), Expect = 4.2 Identities = 32/129 (24%), Positives = 57/129 (44%), Gaps = 20/129 (15%) Query: 396 RTLEDRGIRKISGT---GKALAKTEKYEHKS-------EVKTYDPSGDSTLPTCSKKRKI 445 RT ED ++ S G+ L K E S E+K Y ++ + +K + Sbjct: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLI-LLNKDVQQ 309 Query: 446 EQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEE---------EETSVKKKKKRGKKKHI 496 E +++++ T+K KK K E ++E+K E E+T K +K+ K+K + Sbjct: 310 ESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV 369 Query: 497 KEEPLSEEE 505 + L E+ Sbjct: 370 ESLKLPSEK 378 Score = 30.4 bits (67), Expect = 4.2 Identities = 24/123 (19%), Positives = 53/123 (43%), Gaps = 6/123 (4%) Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEIT---EKKAKKAK 463 S T + E+ S++K + ++R I D E++I ++ +K K Sbjct: 2893 SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPK 2952 Query: 464 IKVKVEEEEEEKVAE---EEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKK 520 + V ++ E E ++ S + K+ ++ +EE E+EP +T ++ + + Sbjct: 2953 RSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQ 3012 Query: 521 KKK 523 + K Sbjct: 3013 RSK 3015 Score = 29.3 bits (64), Expect = 9.3 Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 5/79 (6%) Query: 449 DKEDEITEKKAK---KAKIKVKVEEEEEEKVAEEEETSVK--KKKKRGKKKHIKEEPLSE 503 D + E +E+K K K + K E+ E K ++E+T K KK + +K+E ++ Sbjct: 306 DVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAK 365 Query: 504 EEPCTSTAIASPEKKKKKK 522 E+ S + S + K K Sbjct: 366 EKEVESLKLPSEKNSNKAK 384 >gi|95147555 microtubule-associated protein 1A [Homo sapiens] Length = 2803 Score = 43.9 bits (102), Expect = 4e-04 Identities = 43/154 (27%), Positives = 67/154 (43%), Gaps = 6/154 (3%) Query: 370 IRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYD 429 I+ A ++S A +KL R +E+ S K LAKTEK +S K Sbjct: 313 IKQRADSKESLKATTKTAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEK--- 369 Query: 430 PSGDSTLPTCSKKRKIEQVDKED-EITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKK 488 P P K E + E ++ + K K +K K+ + EE+K E++E +KK++ Sbjct: 370 PPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKKDKEKKE--IKKER 427 Query: 489 KRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKK 522 K KK ++E + + PE KK K Sbjct: 428 KELKKDEGRKEEKKDAKKEEKRKDTKPELKKISK 461 Score = 37.4 bits (85), Expect = 0.034 Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 11/90 (12%) Query: 442 KRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKK-----RGKKKHI 496 K ++ KE TEKKAK++ K + + E+V E ++K +K+ + KKH+ Sbjct: 346 KEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKVGKKHL 405 Query: 497 KEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 KE+ EE EKK+ KK+++E Sbjct: 406 KEKISKLEEK------KDKEKKEIKKERKE 429 Score = 37.0 bits (84), Expect = 0.045 Identities = 30/120 (25%), Positives = 49/120 (40%), Gaps = 4/120 (3%) Query: 411 KALAKTEKYEH----KSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466 K L EK H + V T +PT K KI+Q E + K A K+ Sbjct: 275 KILEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKL 334 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRE 526 EE E+ A+E + + K+ + +KK + E+P + + + K +KR+ Sbjct: 335 AKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRK 394 Score = 32.0 bits (71), Expect = 1.4 Identities = 24/84 (28%), Positives = 46/84 (54%), Gaps = 8/84 (9%) Query: 441 KKRKIEQVDK----EDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHI 496 K +EQ DK +D+ E+K K + K K+ E E++K E+++T++++K K + Sbjct: 1418 KDTALEQKDKALEPKDKDLEEKDKALEQKDKIPE-EKDKALEQKDTALEQKDKALEP--- 1473 Query: 497 KEEPLSEEEPCTSTAIASPEKKKK 520 K++ L +++ PE+K K Sbjct: 1474 KDKDLEQKDRVLEQKEKIPEEKDK 1497 >gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f [Homo sapiens] Length = 1412 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%) Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460 RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K Sbjct: 1271 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1329 Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508 + ++E EE++ + T S K+KKK K+K KE E + + + Sbjct: 1330 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1389 Query: 509 STAIASPEKKKKKKKKRENE 528 + SP +KKKKKKK+ E Sbjct: 1390 TKDSESPSQKKKKKKKKTAE 1409 Score = 34.3 bits (77), Expect = 0.29 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%) Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406 VG +P+ G + + +A EDSSS+ ++ E G+ Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634 Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466 G K++ K + + S V G T P K +T+ KA+K + Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 E EEE +EE S + K KK K P + P I++P K Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734 Score = 31.2 bits (69), Expect = 2.5 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%) Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408 +TS KGK R A+ V + G+ S + G ++ + E + +G+ + G Sbjct: 1305 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1354 Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468 ++ K++K + KS+ KRK ++ KE +KKAKKA K Sbjct: 1355 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1391 Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492 + E S KKKKK+ K Sbjct: 1392 ---------DSESPSQKKKKKKKK 1406 Score = 29.6 bits (65), Expect = 7.1 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%) Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 +A K+ ++ E+E +KV + + S +K + K+K LS ++P T P Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1285 Query: 518 KKKKK 522 KKKKK Sbjct: 1286 KKKKK 1290 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%) Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460 RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K Sbjct: 1310 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1368 Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508 + ++E EE++ + T S K+KKK K+K KE E + + + Sbjct: 1369 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1428 Query: 509 STAIASPEKKKKKKKKRENE 528 + SP +KKKKKKK+ E Sbjct: 1429 TKDSESPSQKKKKKKKKTAE 1448 Score = 34.3 bits (77), Expect = 0.29 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%) Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406 VG +P+ G + + +A EDSSS+ ++ E G+ Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711 Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466 G K++ K + + S V G T P K +T+ KA+K + Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 E EEE +EE S + K KK K P + P I++P K Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811 Score = 31.2 bits (69), Expect = 2.5 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%) Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408 +TS KGK R A+ V + G+ S + G ++ + E + +G+ + G Sbjct: 1344 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1393 Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468 ++ K++K + KS+ KRK ++ KE +KKAKKA K Sbjct: 1394 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1430 Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492 + E S KKKKK+ K Sbjct: 1431 ---------DSESPSQKKKKKKKK 1445 Score = 29.6 bits (65), Expect = 7.1 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%) Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 +A K+ ++ E+E +KV + + S +K + K+K LS ++P T P Sbjct: 1275 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1324 Query: 518 KKKKK 522 KKKKK Sbjct: 1325 KKKKK 1329 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%) Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460 RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K Sbjct: 1347 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1405 Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508 + ++E EE++ + T S K+KKK K+K KE E + + + Sbjct: 1406 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1465 Query: 509 STAIASPEKKKKKKKKRENE 528 + SP +KKKKKKK+ E Sbjct: 1466 TKDSESPSQKKKKKKKKTAE 1485 Score = 34.3 bits (77), Expect = 0.29 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%) Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406 VG +P+ G + + +A EDSSS+ ++ E G+ Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 711 Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466 G K++ K + + S V G T P K +T+ KA+K + Sbjct: 712 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 762 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 E EEE +EE S + K KK K P + P I++P K Sbjct: 763 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811 Score = 31.2 bits (69), Expect = 2.5 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%) Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408 +TS KGK R A+ V + G+ S + G ++ + E + +G+ + G Sbjct: 1381 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1430 Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468 ++ K++K + KS+ KRK ++ KE +KKAKKA K Sbjct: 1431 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1467 Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492 + E S KKKKK+ K Sbjct: 1468 ---------DSESPSQKKKKKKKK 1482 Score = 29.6 bits (65), Expect = 7.1 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%) Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 +A K+ ++ E+E +KV + + S +K + K+K LS ++P T P Sbjct: 1312 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1361 Query: 518 KKKKK 522 KKKKK Sbjct: 1362 KKKKK 1366 >gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo sapiens] Length = 1411 Score = 43.9 bits (102), Expect = 4e-04 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 16/140 (11%) Query: 404 RKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLP---TCSKKRKIEQVDKEDEITEKKAK 460 RK+SG A A+T + + K ++ + S P + + K K ++ ++ EKK K Sbjct: 1270 RKLSGDQPA-ARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1328 Query: 461 KAKIKVKVEEEEEEKVAEEEET----------SVKKKKKRGKKKHIKE--EPLSEEEPCT 508 + ++E EE++ + T S K+KKK K+K KE E + + + Sbjct: 1329 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKAS 1388 Query: 509 STAIASPEKKKKKKKKRENE 528 + SP +KKKKKKK+ E Sbjct: 1389 TKDSESPSQKKKKKKKKTAE 1408 Score = 34.3 bits (77), Expect = 0.29 Identities = 41/171 (23%), Positives = 63/171 (36%), Gaps = 20/171 (11%) Query: 347 VGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKI 406 VG +P+ G + + +A EDSSS+ ++ E G+ Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE---------EKTGLAVT 634 Query: 407 SGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKV 466 G K++ K + + S V G T P K +T+ KA+K + Sbjct: 635 VGQAKSVGKGLQVKAAS-VPVKGSLGQGTAPVLPGKTG-------PTVTQVKAEKQEDS- 685 Query: 467 KVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 E EEE +EE S + K KK K P + P I++P K Sbjct: 686 --ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 734 Score = 31.2 bits (69), Expect = 2.5 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 42/144 (29%) Query: 349 QTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISG 408 +TS KGK R A+ V + G+ S + G ++ + E + +G+ + G Sbjct: 1304 KTSTTSKGKAKRDKASGDVKEKK----GKGSLGSQGAKDEPEEELQ------KGMGTVEG 1353 Query: 409 TGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKV 468 ++ K++K + KS+ KRK ++ KE +KKAKKA K Sbjct: 1354 GDQSNPKSKKEKKKSD-----------------KRKKDKEKKE---KKKKAKKASTK--- 1390 Query: 469 EEEEEEKVAEEEETSVKKKKKRGK 492 + E S KKKKK+ K Sbjct: 1391 ---------DSESPSQKKKKKKKK 1405 Score = 29.6 bits (65), Expect = 7.1 Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 10/65 (15%) Query: 458 KAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEK 517 +A K+ ++ E+E +KV + + S +K + K+K LS ++P T P Sbjct: 1235 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRK------LSGDQPAART----PRS 1284 Query: 518 KKKKK 522 KKKKK Sbjct: 1285 KKKKK 1289 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.129 0.354 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,410,898 Number of Sequences: 37866 Number of extensions: 841474 Number of successful extensions: 20344 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 440 Number of HSP's successfully gapped in prelim test: 558 Number of HSP's that attempted gapping in prelim test: 7543 Number of HSP's gapped (non-prelim): 6449 length of query: 529 length of database: 18,247,518 effective HSP length: 107 effective length of query: 422 effective length of database: 14,195,856 effective search space: 5990651232 effective search space used: 5990651232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.