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Search of human proteins with 13994268
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13994268 ubiquitin-specific protease 26 [Homo sapiens]
(913 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13994268 ubiquitin-specific protease 26 [Homo sapiens] 1839 0.0
gi|10190742 ubiquitin specific peptidase 29 [Homo sapiens] 714 0.0
gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens] 623 e-178
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 71 5e-12
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 69 3e-11
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 69 3e-11
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 69 3e-11
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 69 3e-11
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 66 2e-10
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 66 2e-10
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 65 2e-10
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 65 3e-10
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 65 3e-10
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 64 5e-10
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 64 5e-10
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 61 5e-09
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 60 7e-09
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 57 6e-08
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 57 1e-07
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens] 56 2e-07
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 55 3e-07
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 55 4e-07
gi|164607167 ubiquitin specific peptidase 30 [Homo sapiens] 55 4e-07
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 54 7e-07
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 53 1e-06
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 51 6e-06
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 50 1e-05
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 49 3e-05
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 48 4e-05
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 48 4e-05
>gi|13994268 ubiquitin-specific protease 26 [Homo sapiens]
Length = 913
Score = 1839 bits (4764), Expect = 0.0
Identities = 913/913 (100%), Positives = 913/913 (100%)
Query: 1 MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVV 60
MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVV
Sbjct: 1 MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYSTFRLSDNIQNVV 60
Query: 61 LKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFS 120
LKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFS
Sbjct: 61 LKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVFS 120
Query: 121 STTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKR 180
STTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKR
Sbjct: 121 STTQKEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKLTLTCGELSENQHKKR 180
Query: 181 KRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCI 240
KRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCI
Sbjct: 181 KRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECESSCI 240
Query: 241 MNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNL 300
MNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNL
Sbjct: 241 MNATGNPYLDDIGLLQALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHGLPNL 300
Query: 301 GNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEML 360
GNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEML
Sbjct: 301 GNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEML 360
Query: 361 LLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQV 420
LLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQV
Sbjct: 361 LLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQV 420
Query: 421 FADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQ 480
FADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQ
Sbjct: 421 FADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHPSSIQ 480
Query: 481 STFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVI 540
STFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVI
Sbjct: 481 STFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVI 540
Query: 541 ISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAP 600
ISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAP
Sbjct: 541 ISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATKESKDILAP 600
Query: 601 HIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTY 660
HIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTY
Sbjct: 601 HIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKEPLAHLMTY 660
Query: 661 LEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDL 720
LEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDL
Sbjct: 661 LEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFDRIINPTKDL 720
Query: 721 YEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNL 780
YEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNL
Sbjct: 721 YEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTKNLLRPTKLNL 780
Query: 781 QKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSG 840
QKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSG
Sbjct: 781 QKSNRNSLLALGSNKNPRNKDILDKIKSKAKETKRNDDKGDHTYRLISVVSHLGKTLKSG 840
Query: 841 HYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQ 900
HYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQ
Sbjct: 841 HYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFEEMLKREENAQ 900
Query: 901 LNSKEVEETLQKE 913
LNSKEVEETLQKE
Sbjct: 901 LNSKEVEETLQKE 913
>gi|10190742 ubiquitin specific peptidase 29 [Homo sapiens]
Length = 922
Score = 714 bits (1843), Expect = 0.0
Identities = 429/920 (46%), Positives = 566/920 (61%), Gaps = 31/920 (3%)
Query: 1 MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKY-STFRLSDNIQNV 59
M +L + GF+QI + KTG++K KEA IE V+R+K+ +LV+ FKSGK+ F+LS+NI++V
Sbjct: 1 MISLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSV 60
Query: 60 VLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVF 119
VL+ + Q+HL LTL+NN LFI+ LS DA+QL +FLD +HQN+ Q P++ SVF
Sbjct: 61 VLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFLDIIHQNKSQQPMKSDDDWSVF 120
Query: 120 SSTTQ-KEINKTSFHKVDEKSSSKSFEIAKGSGTGVLQRMPLLTSKL-TLTCGELSENQH 177
S KEI+KTSF+ + K S Q+MPL SK T + ENQ
Sbjct: 121 ESRNMLKEIDKTSFYSICNKPS--------------YQKMPLFMSKSPTHVKKGILENQG 166
Query: 178 KKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSRCVSYNREKQLKLKELEENKKLECES 237
K + LSS + NE+ LKE+N V KK K D + + NR+ L++LE+++ L+
Sbjct: 167 GKGQNTLSSDVQTNEDILKEDNPVPNKKYKTDSLKYIQSNRKNPSSLEDLEKDRDLKLGP 226
Query: 238 SCIMNATGNPYLDDIGLL-QALTEKMVLVFLLQQGYSDGYTKWDKLKLFFELFPEKICHG 296
S N GNP LD+ L Q L K L L+ +S G + +K ++ + +++ G
Sbjct: 227 SFNTNCNGNPNLDETVLATQTLNAKNGLTSPLEPEHSQGDPRCNKAQVPLDSHSQQLQQG 286
Query: 297 LPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEI 356
PNLGNTCYMNAVLQSL +IPSFADDLL Q PW IP AL M L +LL KD + +I
Sbjct: 287 FPNLGNTCYMNAVLQSLFAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKI 346
Query: 357 KEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNF 416
K LL N+KK ISA AEIF GN QNDAHEFL CLDQLK++MEKLN E G++N
Sbjct: 347 KRELLGNVKKVISAVAEIFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECGDENS 406
Query: 417 PKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIKAHP 476
Q+ T F CPV+ NFE EL S+ CKACG +LK E NNYLSINL Q K P
Sbjct: 407 SPQMHVGSAATKVFVCPVVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLP 466
Query: 477 SSIQSTFDLFFGAEELEYKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKKND 536
SIQ++ DLFF EELEY C C+ K+ V H+FSRL R+LI+HLKRYS N L KN+
Sbjct: 467 LSIQNSLDLFFKEEELEYNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWLLVKNN 526
Query: 537 QEVIISKYLKVSSHCNEGTRPPLPLSEDGEITDFQLLKVIRKMTS---GNISVSWPATKE 593
++V I K L +SS+CNE T+PPLPLS + ++L+V ++M S ++ S T E
Sbjct: 527 EQVYIPKSLSLSSYCNESTKPPLPLSSSAPVGKCEVLEVSQEMISEINSPLTPSMKLTSE 586
Query: 594 SKDILAPHIGSDKESEQKKGQTVFKGASRRQQQKYLGKNSKPNELESVYSGDRAFIEKE- 652
S D L + DK ++ ++ Q AS+ Q Q+ L +N E E V+ DRA EKE
Sbjct: 587 SSDSLVLPVEPDKNADLQRFQRDCGDASQEQHQRDL-ENGSALESELVHFRDRAIGEKEL 645
Query: 653 PLAHLMTYLEDTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVA--F 710
P+A + D SL ++ GGK SSP T L +V Q VP++P+ +KY KT+ FV F
Sbjct: 646 PVADSLMDQGDISLPVMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNTFVEFNF 705
Query: 711 DRIINPTKDLYEDKNIRIPERFQKVSEQTQQCDGMRICEQAPQQALPQSFPKPGTQGHTK 770
D + T Y+ K RIPE Q ++EQ QQC I ++ QQA P K Q HT+
Sbjct: 706 DSVTESTNGFYDCKENRIPEGSQGMAEQLQQCIEESIIDEFLQQAPPPGVRKLDAQEHTE 765
Query: 771 NLL-RPTKLNLQKSNRNSLLALGSNKNPRNKDILD--KIKSKAKETKRNDDKGD--HTYR 825
L + T+L LQK++ N L ALGS+ NP NK+ILD + +AKE RN GD YR
Sbjct: 766 ETLNQSTELRLQKADLNHLGALGSD-NPGNKNILDAENTRGEAKELTRNVKMGDPLQAYR 824
Query: 826 LISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMH 885
LISVVSH+G + SGHYI D YDF+KQ WFTY+D+ V I E +MQE R +GYIFFYMH
Sbjct: 825 LISVVSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFYMH 884
Query: 886 NEIFEEMLKREENAQLNSKE 905
N IFEE+L++ EN++L S +
Sbjct: 885 NGIFEELLRKAENSRLPSTQ 904
>gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens]
Length = 979
Score = 623 bits (1606), Expect = e-178
Identities = 410/982 (41%), Positives = 565/982 (57%), Gaps = 75/982 (7%)
Query: 1 MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYST-FRLSDNIQNV 59
M+ L + G ++I + +TGI+K KE E VE++ K LV+++ +G F+LS NI+NV
Sbjct: 1 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV 60
Query: 60 VLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVF 119
VL+ Q+ L LTLQ+N+ L I+ + S DAE++++FLD VHQN + ++P +G F
Sbjct: 61 VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF 120
Query: 120 -----SSTTQKEINKTSFHKVDEKSSSKSF-------------------EIAKGSGTGVL 155
S T+QKE ++ + ++ S+ + I +G+G+
Sbjct: 121 GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA 180
Query: 156 QRMPLLTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSR-CV 214
+ +P LTS T L EN+ +KRKRM+S+ SE+NE++ KEN+S K+ D SR +
Sbjct: 181 RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL 240
Query: 215 SYNREKQLKLKELEENKK---LECESSCIM--------NATGNPYLDDIGLL-QALTEKM 262
+ +REKQL LK+ EEN+ L +SS +++G LD + Q + K
Sbjct: 241 TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR 300
Query: 263 VLVFLLQQ--------GYSDGYTKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLL 314
L FL Q + YT W+K ++ ++ G NLGNTCYMNA+LQSL
Sbjct: 301 SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF 360
Query: 315 SIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEI 374
S+ SFA+DLL Q PW KIPLNAL A LL KD N E K+ LL +K AISA AE
Sbjct: 361 SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER 420
Query: 375 FHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPV 434
F G QNDAHEFL+ CLDQLK++MEKLN WK + GE+N P D T ++CPV
Sbjct: 421 FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSP-----DISATRAYTCPV 475
Query: 435 ITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIK-AHPSSIQSTFDLFFGAEELE 493
ITN E E+ HSI CKACG++I K E N LSI+LP+R K P SIQ + DLFF AEELE
Sbjct: 476 ITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELE 535
Query: 494 YKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCAL-KKNDQEVIISKYLKVSSHCN 552
Y C KC K ++ H F+RLPR+LI+HLKRYS N +L K Q+VII +YL +SSHC
Sbjct: 536 YSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCT 595
Query: 553 EGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATK---ESKDILAPHIGSDKESE 609
E T+PP L + + LK + + S S S P+ K +SK LA + SD E E
Sbjct: 596 ENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDE 655
Query: 610 QKK----GQTVFKGASRRQQQKYLGKNSK-----PNELESVYSGDRAFIEKEPLAHLMTY 660
K+ Q + + QQQ+ L K+SK P++ E SG E+E LA ++
Sbjct: 656 LKRSVALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEI 715
Query: 661 LE-DTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFD--RIINPT 717
+ D S H+ KP SSP T ++ D Q +PENP + K D T
Sbjct: 716 SKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEIT 775
Query: 718 KDLYEDKNIRIPERFQKVSEQTQQCDGMRIC-EQAPQQALPQSFPKPGT--QGHTKNLLR 774
KD E+K + PE Q + QQ D R EQ QQAL QS + Q +L R
Sbjct: 776 KDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKR 835
Query: 775 PTKLNLQKSNRNSLLALGSNKNPRNKDILDK--IKSKAKETKRNDDKGD--HTYRLISVV 830
T+L+LQ+ N + + ALGS+++ N+D+ D +++A+E KRN + G+ H+YRLISVV
Sbjct: 836 ATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVV 895
Query: 831 SHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFE 890
SH+G T SGHYI D YD +KQ WFTY+D+ V IQEA +Q DR +GYIFFYMH EIF+
Sbjct: 896 SHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFD 955
Query: 891 EMLKREENAQLNSKEVEETLQK 912
E+L+ E+N+Q S EV +T ++
Sbjct: 956 ELLETEKNSQSLSTEVGKTTRQ 977
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 70.9 bits (172), Expect = 5e-12
Identities = 75/272 (27%), Positives = 116/272 (42%), Gaps = 25/272 (9%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLL-NQSFPWGKIPLNALTMCLARLLFFKDTYNI 354
GL N GNTCY N+VLQ+L F + +L +S P K +L CLA L T
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKK---ESLLTCLADLFHSIAT--- 93
Query: 355 EIKEMLLLNLKKAISAAA---EIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEF 411
+ K++ ++ KK I+ E+F Q DAHEFL + L+ + D +++ K
Sbjct: 94 QKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRL 153
Query: 412 GEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQR 471
N + PD + V F+ L + C C + K E LS+++ Q
Sbjct: 154 PNGNIDNENNNSTPDPTW----VDEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQN 209
Query: 472 IKAHPSSIQSTFDLFFGAE----ELEYKCAKCEHKTSVGVH-SFSRLPRILIVHLKRYS- 525
+SI F E E +Y C +C K +LP IL +HLKR+
Sbjct: 210 -----TSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY 264
Query: 526 LNEFCALKKNDQEVIISKYLKVSSHCNEGTRP 557
+++ K V+ L++ + + T P
Sbjct: 265 MDQLHRYTKLSYRVVFPLELRLFNTSGDATNP 296
Score = 34.3 bits (77), Expect = 0.54
Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 15/78 (19%)
Query: 821 DHTYRLISVVSHLGKTLKSGHYIC--DAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCT- 877
D Y L++VV H G GHYI ++DF W +DD V I ++E T
Sbjct: 297 DRMYDLVAVVVHCGSGPNRGHYIAIVKSHDF----WLLFDDDIVEKIDAQAIEEFYGLTS 352
Query: 878 --------GYIFFYMHNE 887
GYI FY +
Sbjct: 353 DISKNSESGYILFYQSRD 370
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 68.6 bits (166), Expect = 3e-11
Identities = 57/202 (28%), Positives = 94/202 (46%), Gaps = 22/202 (10%)
Query: 291 EKIC----HGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSF--------PWGKIPLNAL 338
+K+C GL NLGNTC+MN+V+QSL + D ++SF P G A+
Sbjct: 489 KKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAI 548
Query: 339 TMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNM 398
+ +K T++ LK +++ A F G AQ+DA EF+A LD L +++
Sbjct: 549 GFAVLLRALWKGTHH----AFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDL 604
Query: 399 EKLNTIWKPKSE-FGEDNFPKQVFADDP---DTSGFSCPVITNFELELLHSIACKACGQV 454
++ KP +E D P +V A++ ++ F+ + + C C +V
Sbjct: 605 NRIQN--KPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKV 662
Query: 455 ILKTELNNYLSINLPQRIKAHP 476
+ + YL + LPQ+ K P
Sbjct: 663 SITFDPFLYLPVPLPQKQKVLP 684
Score = 31.6 bits (70), Expect = 3.5
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 2/74 (2%)
Query: 489 AEELEYKCAKC-EHKTSVGVHSFSRLPRILIVHLKRYSLNEFCALKK-NDQEVIISKYLK 546
A E + C +C +H+ + RLP +LIV LKR+S F K ND + L
Sbjct: 1074 APEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLD 1133
Query: 547 VSSHCNEGTRPPLP 560
+S C LP
Sbjct: 1134 LSKFCIGQKEEQLP 1147
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 16/242 (6%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARL-----LFFKD 350
GL NLGNTCYMN++LQ L + P A D N++ I + L + + K
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLA-DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKA 836
Query: 351 TYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSE 410
+ + + + + K I + F G +Q D+ E L +D L +++ K + + K E
Sbjct: 837 LWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEE 896
Query: 411 FGE--DNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINL 468
+ D+F A ++ F+ + ++ C C + E YLS+ L
Sbjct: 897 NNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL 956
Query: 469 PQRIKAHPSSIQSTFDLFFGAEEL----EYKCAKCE-HKTSVGVHSFSRLPRILIVHLKR 523
K ++Q LF E+L + C+ C + S+ +LP +L+VHLKR
Sbjct: 957 ASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKR 1013
Query: 524 YS 525
+S
Sbjct: 1014 FS 1015
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 4/60 (6%)
Query: 824 YRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFY 883
Y L SV +H G L GHY + +Q WF +DD V I + ++ YI FY
Sbjct: 1051 YNLFSVSNHYGG-LDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 16/242 (6%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARL-----LFFKD 350
GL NLGNTCYMN++LQ L + P A D N++ I + L + + K
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLA-DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKA 836
Query: 351 TYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSE 410
+ + + + + K I + F G +Q D+ E L +D L +++ K + + K E
Sbjct: 837 LWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEE 896
Query: 411 FGE--DNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINL 468
+ D+F A ++ F+ + ++ C C + E YLS+ L
Sbjct: 897 NNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL 956
Query: 469 PQRIKAHPSSIQSTFDLFFGAEEL----EYKCAKCE-HKTSVGVHSFSRLPRILIVHLKR 523
K ++Q LF E+L + C+ C + S+ +LP +L+VHLKR
Sbjct: 957 ASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKR 1013
Query: 524 YS 525
+S
Sbjct: 1014 FS 1015
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 4/60 (6%)
Query: 824 YRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFY 883
Y L SV +H G L GHY + +Q WF +DD V I + ++ YI FY
Sbjct: 1051 YNLFSVSNHYGG-LDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 16/242 (6%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARL-----LFFKD 350
GL NLGNTCYMN++LQ L + P A D N++ I + L + + K
Sbjct: 778 GLRNLGNTCYMNSILQCLCNAPHLA-DYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKA 836
Query: 351 TYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSE 410
+ + + + + K I + F G +Q D+ E L +D L +++ K + + K E
Sbjct: 837 LWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEE 896
Query: 411 FGE--DNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINL 468
+ D+F A ++ F+ + ++ C C + E YLS+ L
Sbjct: 897 NNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL 956
Query: 469 PQRIKAHPSSIQSTFDLFFGAEEL----EYKCAKCE-HKTSVGVHSFSRLPRILIVHLKR 523
K ++Q LF E+L + C+ C + S+ +LP +L+VHLKR
Sbjct: 957 ASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKR 1013
Query: 524 YS 525
+S
Sbjct: 1014 FS 1015
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 4/60 (6%)
Query: 824 YRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFY 883
Y L SV +H G L GHY + +Q WF +DD V I + ++ YI FY
Sbjct: 1051 YNLFSVSNHYGG-LDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 65.9 bits (159), Expect = 2e-10
Identities = 71/260 (27%), Positives = 111/260 (42%), Gaps = 35/260 (13%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIP----LNALTMCLARL---LFF 348
GL NLGNTC++NAVLQ L S D L + F ++P LT A + L+
Sbjct: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQ-EVPGGGRAQELTEAFADVIGALWH 271
Query: 349 KDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPK 408
D+ +K + + F G +Q DA EFL +++L + + P
Sbjct: 272 PDSCEAVNPTRFRAVFQKYVPS----FSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPI 327
Query: 409 SEFGEDNFPKQ---VFADDPDTSGFS--------------CPVITNFELELLHSIACKAC 451
G P + ++P+ S ++ F +L + C+AC
Sbjct: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 452 GQVILKTELNNYLSINLPQR-IKAHPSSIQSTFDLFFGAEELEYK----CAKCEHKT-SV 505
G E+ LS+ +P++ S++ F+LF EELE + C +C KT S
Sbjct: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
Query: 506 GVHSFSRLPRILIVHLKRYS 525
+ R PRIL++HL R+S
Sbjct: 448 KKLTVQRFPRILVLHLNRFS 467
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 65.9 bits (159), Expect = 2e-10
Identities = 71/260 (27%), Positives = 111/260 (42%), Gaps = 35/260 (13%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIP----LNALTMCLARL---LFF 348
GL NLGNTC++NAVLQ L S D L + F ++P LT A + L+
Sbjct: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQ-EVPGGGRAQELTEAFADVIGALWH 271
Query: 349 KDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPK 408
D+ +K + + F G +Q DA EFL +++L + + P
Sbjct: 272 PDSCEAVNPTRFRAVFQKYVPS----FSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPI 327
Query: 409 SEFGEDNFPKQ---VFADDPDTSGFS--------------CPVITNFELELLHSIACKAC 451
G P + ++P+ S ++ F +L + C+AC
Sbjct: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 452 GQVILKTELNNYLSINLPQR-IKAHPSSIQSTFDLFFGAEELEYK----CAKCEHKT-SV 505
G E+ LS+ +P++ S++ F+LF EELE + C +C KT S
Sbjct: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
Query: 506 GVHSFSRLPRILIVHLKRYS 525
+ R PRIL++HL R+S
Sbjct: 448 KKLTVQRFPRILVLHLNRFS 467
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 65.5 bits (158), Expect = 2e-10
Identities = 65/241 (26%), Positives = 104/241 (43%), Gaps = 19/241 (7%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWG----KIPLNALTMCLARLLFFKDT 351
GL NLGNTC +NA+ Q L SI + L + +P + + A D
Sbjct: 45 GLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLMTDM 104
Query: 352 YNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEF 411
+ + + A+ F Q DA EFL L++L + ++K + + E
Sbjct: 105 WLGDSDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRRRSYEK 164
Query: 412 GEDNFPKQVFADDPDTSGFSCPVITN-FELELLHSIACKACGQVILKTELNNYLSINLPQ 470
G + + +TS +IT FE +L +SI C C + K E+ S+ +P
Sbjct: 165 GSTQRCCRKWI-TTETS-----IITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLPIPS 218
Query: 471 RIKAHPSSIQSTFDLFFGAEEL----EYKCAKCEHKTSVGVH-SFSRLPRILIVHLKRYS 525
+ + S++ FF + L E C+ CE K V S S+ P+I+I HLKR+
Sbjct: 219 K---YECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKRFD 275
Query: 526 L 526
+
Sbjct: 276 I 276
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 65.1 bits (157), Expect = 3e-10
Identities = 70/253 (27%), Positives = 104/253 (41%), Gaps = 37/253 (14%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSF----PWGKIPLNALTMCLARLL--FFK 349
GL NLGNTC+MN++LQ L + D L + + G AL A+L+ +
Sbjct: 59 GLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWT 118
Query: 350 DTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQL-----------KDNM 398
+ N + K I A F G Q DA EFL LD L K N
Sbjct: 119 SSPNDVVSPS---EFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNP 175
Query: 399 EKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKT 458
E L+ + P E G + K + +D F +L S+ C CG T
Sbjct: 176 ENLDHL--PDDEKGRQMWRKYLEREDSRIGDL-------FVGQLKSSLTCTDCG--YCST 224
Query: 459 ELNNYLSINLPQRIKAHPS-SIQSTFDLFFGAEELE----YKCAKCE-HKTSVGVHSFSR 512
+ + ++LP + +P ++ LF + L+ C +C K + S R
Sbjct: 225 VFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQR 284
Query: 513 LPRILIVHLKRYS 525
P+IL++HLKR+S
Sbjct: 285 FPKILVLHLKRFS 297
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 65.1 bits (157), Expect = 3e-10
Identities = 70/253 (27%), Positives = 104/253 (41%), Gaps = 37/253 (14%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSF----PWGKIPLNALTMCLARLL--FFK 349
GL NLGNTC+MN++LQ L + D L + + G AL A+L+ +
Sbjct: 268 GLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWT 327
Query: 350 DTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQL-----------KDNM 398
+ N + K I A F G Q DA EFL LD L K N
Sbjct: 328 SSPNDVVSPS---EFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNP 384
Query: 399 EKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKT 458
E L+ + P E G + K + +D F +L S+ C CG T
Sbjct: 385 ENLDHL--PDDEKGRQMWRKYLEREDSRIGDL-------FVGQLKSSLTCTDCG--YCST 433
Query: 459 ELNNYLSINLPQRIKAHPS-SIQSTFDLFFGAEELE----YKCAKCE-HKTSVGVHSFSR 512
+ + ++LP + +P ++ LF + L+ C +C K + S R
Sbjct: 434 VFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQR 493
Query: 513 LPRILIVHLKRYS 525
P+IL++HLKR+S
Sbjct: 494 FPKILVLHLKRFS 506
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 64.3 bits (155), Expect = 5e-10
Identities = 71/241 (29%), Positives = 104/241 (43%), Gaps = 22/241 (9%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIE 355
GL N GNTCY N+VLQ+L F +++L K N LT CLA L T +
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK-KENLLT-CLADLFHSIAT---Q 83
Query: 356 IKEMLLLNLKKAISAAA---EIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFG 412
K++ ++ KK IS ++F Q DAHEFL + L+ + D +++ K +
Sbjct: 84 KKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLK 143
Query: 413 EDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRI 472
N + + P+ + V F+ L + C C V K E LS+++ Q
Sbjct: 144 NGNMNEPAENNKPELTW----VHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQN- 198
Query: 473 KAHPSSIQSTFDLFFGAE----ELEYKCAKCEHKTSVGVH-SFSRLPRILIVHLKRYSLN 527
+SI F E E +Y C C K +LP IL +HLKR+
Sbjct: 199 ----TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYM 254
Query: 528 E 528
E
Sbjct: 255 E 255
Score = 32.3 bits (72), Expect = 2.1
Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 11/76 (14%)
Query: 821 DHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCT--- 877
D Y L++VV H G GHYI W +DD V I ++E T
Sbjct: 286 DRMYDLVAVVVHCGSGPNRGHYITIVK--SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDI 343
Query: 878 ------GYIFFYMHNE 887
GYI FY E
Sbjct: 344 SKNSESGYILFYQSRE 359
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 64.3 bits (155), Expect = 5e-10
Identities = 71/241 (29%), Positives = 104/241 (43%), Gaps = 22/241 (9%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIE 355
GL N GNTCY N+VLQ+L F +++L K N LT CLA L T +
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK-KENLLT-CLADLFHSIAT---Q 90
Query: 356 IKEMLLLNLKKAISAAA---EIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFG 412
K++ ++ KK IS ++F Q DAHEFL + L+ + D +++ K +
Sbjct: 91 KKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLK 150
Query: 413 EDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRI 472
N + + P+ + V F+ L + C C V K E LS+++ Q
Sbjct: 151 NGNMNEPAENNKPELTW----VHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQN- 205
Query: 473 KAHPSSIQSTFDLFFGAE----ELEYKCAKCEHKTSVGVH-SFSRLPRILIVHLKRYSLN 527
+SI F E E +Y C C K +LP IL +HLKR+
Sbjct: 206 ----TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYM 261
Query: 528 E 528
E
Sbjct: 262 E 262
Score = 32.3 bits (72), Expect = 2.1
Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 11/76 (14%)
Query: 821 DHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCT--- 877
D Y L++VV H G GHYI W +DD V I ++E T
Sbjct: 293 DRMYDLVAVVVHCGSGPNRGHYITIVK--SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDI 350
Query: 878 ------GYIFFYMHNE 887
GYI FY E
Sbjct: 351 SKNSESGYILFYQSRE 366
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 60.8 bits (146), Expect = 5e-09
Identities = 51/191 (26%), Positives = 87/191 (45%), Gaps = 18/191 (9%)
Query: 291 EKICHGLPNLGNTCYMNAVLQSLLSIPSFADDL--------LNQSFPWGKIPLNALTMCL 342
EK GL NLGNTC+MN+ +Q + + LN++ P G + C
Sbjct: 528 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGM--KGHMAKCY 585
Query: 343 ARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLN 402
L+ ++ ++ K + L L++ I+ A F G Q D+ E LA LD L +++ +++
Sbjct: 586 GDLV--QELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVH 643
Query: 403 TIWKP----KSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKT 458
KP K G ++ A D ++ F +L + CK CG + ++
Sbjct: 644 E--KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRF 701
Query: 459 ELNNYLSINLP 469
+ N+LS+ LP
Sbjct: 702 DPFNFLSLPLP 712
Score = 37.7 bits (86), Expect = 0.049
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 5/70 (7%)
Query: 460 LNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELE----YKCAKCE-HKTSVGVHSFSRLP 514
++ + S+ +R +A P ++ S F EEL Y C+KC+ H + RLP
Sbjct: 1014 VDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLP 1073
Query: 515 RILIVHLKRY 524
LI+HLKR+
Sbjct: 1074 PFLIIHLKRF 1083
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 60.5 bits (145), Expect = 7e-09
Identities = 53/197 (26%), Positives = 88/197 (44%), Gaps = 18/197 (9%)
Query: 291 EKICHGLPNLGNTCYMNAVLQSLLSIPSFADDL--------LNQSFPWGKIPLNALTMCL 342
EK GL NLGNTC+MN+ +Q + + LN++ P G + C
Sbjct: 730 EKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGM--KGHMAKCY 787
Query: 343 ARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLN 402
L+ ++ ++ K + L L+ I+ A F+G Q D+ E LA LD L +++ +++
Sbjct: 788 GDLV--QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVH 845
Query: 403 TIWKP----KSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKT 458
KP K G ++ A D V+ F +L + CK CG + ++
Sbjct: 846 E--KPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRF 903
Query: 459 ELNNYLSINLPQRIKAH 475
+ N+LS+ LP H
Sbjct: 904 DPFNFLSLPLPMDSYMH 920
Score = 39.3 bits (90), Expect = 0.017
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 5/70 (7%)
Query: 460 LNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELE----YKCAKCE-HKTSVGVHSFSRLP 514
++ + S+ +R +A P ++ S F EEL Y C+KC+ H + RLP
Sbjct: 1216 VDEHESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLP 1275
Query: 515 RILIVHLKRY 524
ILI+HLKR+
Sbjct: 1276 PILIIHLKRF 1285
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 57.4 bits (137), Expect = 6e-08
Identities = 68/260 (26%), Positives = 108/260 (41%), Gaps = 36/260 (13%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIE 355
GL NLGNTC+MNA+LQSL +I F + P ++ + N+
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFC--CYFKELPAVELRNGKTAGRRTYHTRSQGDNNVS 217
Query: 356 IKEMLLLNL-------KKAISAAAEI---------FHGNAQNDAHEFLAHCLDQLKDNME 399
+ E L + A S + F G Q DAHEF+ + LD L ++
Sbjct: 218 LVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQ 277
Query: 400 -KLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKT 458
N + +S ++N ++ +G S V F L + + C CG K
Sbjct: 278 GGFNGV--SRSAILQENSTLSA-SNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKF 334
Query: 459 ELNNYLSINLPQRIKAHPS---------SIQSTFDLFFGAEELE----YKCAKCEHK-TS 504
+ LS+++P + ++ S S++ F EEL+ Y C KC+ K S
Sbjct: 335 DPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKS 394
Query: 505 VGVHSFSRLPRILIVHLKRY 524
+LP++L +HLKR+
Sbjct: 395 TKKFWIQKLPKVLCLHLKRF 414
Score = 33.5 bits (75), Expect = 0.93
Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 5/64 (7%)
Query: 824 YRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFY 883
Y L +VV H G + SGHY AY + WF ++D V E + + YI FY
Sbjct: 454 YDLAAVVVHHGSGVGSGHY--TAYATHEGRWFHFNDSTVTLTDEETVV---KAKAYILFY 508
Query: 884 MHNE 887
+ ++
Sbjct: 509 VEHQ 512
>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
Length = 1316
Score = 56.6 bits (135), Expect = 1e-07
Identities = 69/256 (26%), Positives = 102/256 (39%), Gaps = 45/256 (17%)
Query: 288 LFP-EKIC----------HGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLN 336
LFP EKIC GL NLGNTC+ NA LQ L P A+ +L+
Sbjct: 93 LFPSEKICLKWQQTHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEG 152
Query: 337 ALTMCLARLLFFKDTYN--IEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQL 394
MC + + N IK M ++N + I A F Q DAHEFL + +D +
Sbjct: 153 FCMMCTMQAHITQALSNPGDVIKPMFVINEMRRI---ARHFRFGNQEDAHEFLQYTVDAM 209
Query: 395 KDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQV 454
+ LN G + + A + C + + + + CK
Sbjct: 210 QKAC--LN---------GSNKLDRHTQA-----TTLVCQIFGGYLRSRVKCLNCKG---- 249
Query: 455 ILKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELE----YKCAKCEHKTSVGVH-S 509
+ + YL I L IKA S+ + F E+L+ YKC+KC+ +
Sbjct: 250 -VSDTFDPYLDITL--EIKA-AQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFT 305
Query: 510 FSRLPRILIVHLKRYS 525
R +L + LKR++
Sbjct: 306 IHRSSNVLTLSLKRFA 321
>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
Length = 1123
Score = 55.8 bits (133), Expect = 2e-07
Identities = 62/238 (26%), Positives = 97/238 (40%), Gaps = 36/238 (15%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLAR---LLFFKDTY 352
GL NLGNTC++NA +Q L P A+ LL++ + +C+ + + F ++
Sbjct: 123 GLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSG 182
Query: 353 NIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFG 412
N + +LKK A F Q DAHEFL + +D ++ LN K +
Sbjct: 183 NAIKPVSFIRDLKK----IARHFRFGNQEDAHEFLRYTIDAMQKAC--LNGCAKLDRQTQ 236
Query: 413 EDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRI 472
Q+F G+ L + C C V + YL + L R
Sbjct: 237 ATTLVHQIF------GGY-----------LRSRVKCSVCKSV--SDTYDPYLDVALEIR- 276
Query: 473 KAHPSSIQSTFDLFFGAEELE----YKCAKCEHKTSVGVH-SFSRLPRILIVHLKRYS 525
++I +LF A+ L Y CAKC+ K + R +L + LKR++
Sbjct: 277 --QAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFA 332
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 55.1 bits (131), Expect = 3e-07
Identities = 71/294 (24%), Positives = 115/294 (39%), Gaps = 59/294 (20%)
Query: 270 QGYSDGYTKWDKLKLFFELFPE-----KIC-------HGLPNLGNTCYMNAVLQSLLSIP 317
QG + ++ W+ K EL KI GL NLGNTC+MN ++Q+L P
Sbjct: 139 QGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTP 198
Query: 318 SFADDLLNQSFPWGKIPLNALTMCLARLL--FFKDTYNIEIKEMLLLNLKKAISAAAEIF 375
D L+ + + + + CL + F++ Y+ + L + A
Sbjct: 199 LLRDFFLSDRH---RCEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHL 255
Query: 376 HGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVI 435
G Q DAHEFL LD L + + G+DN K A++P+ +C +
Sbjct: 256 AGYEQQDAHEFLIAALDVLHRHCK------------GDDNGKK---ANNPNHC--NCIID 298
Query: 436 TNFELELLHSIACKACGQVILKTELNNYLSINLPQRI-----------------KAHPSS 478
F L + C+ C V + +S++LP ++H S
Sbjct: 299 QIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSG 358
Query: 479 IQSTFDL---FFGAEEL----EYKCAKC-EHKTSVGVHSFSRLPRILIVHLKRY 524
+ D F E L + KC+ C ++ S + +LP + HLKR+
Sbjct: 359 TTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF 412
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 54.7 bits (130), Expect = 4e-07
Identities = 65/256 (25%), Positives = 99/256 (38%), Gaps = 47/256 (18%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLL--FFKDTYN 353
GL NLGNTC+MN ++Q+L IP D L+ K + + ++CL + F Y+
Sbjct: 364 GLINLGNTCFMNCIVQALTHIPLLKDFFLSDKH---KCIMTSPSLCLVCEMSSLFHAMYS 420
Query: 354 IEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGE 413
+ L I AE G Q DAHEFL LD L + K + G
Sbjct: 421 GSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRH---------SKDDSGG 471
Query: 414 DNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIK 473
A++P+ +C + F L + C+AC V + +S++LP
Sbjct: 472 QE------ANNPNCC--NCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCA 523
Query: 474 AHPS--------------------SIQSTFDLFFGAEEL----EYKCAKCE-HKTSVGVH 508
S S+ F E L + KC C+ ++ S
Sbjct: 524 TFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQL 583
Query: 509 SFSRLPRILIVHLKRY 524
+ +LP + HLKR+
Sbjct: 584 TMKKLPIVACFHLKRF 599
>gi|164607167 ubiquitin specific peptidase 30 [Homo sapiens]
Length = 517
Score = 54.7 bits (130), Expect = 4e-07
Identities = 70/287 (24%), Positives = 119/287 (41%), Gaps = 43/287 (14%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSF---ADDLLNQSFPWGKIPLN--ALTMCLARLLFFKD 350
GL NLGNTC+MN++LQ L + P+F ++ +Q K P + L++ L LL
Sbjct: 69 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 128
Query: 351 TYNIEIKEML----LLNLKKAISAAAEIFHGNAQNDAHEF---LAHCLDQLKDNMEKLNT 403
+ E+L LL++ + F + DAHE + L+ +D ++
Sbjct: 129 CQEVTDDEVLDASCLLDVLRMYRWQISSFE---EQDAHELFHVITSSLEDERDRQPRVTH 185
Query: 404 IWKPKS-EFGEDNFPKQVFADDPDTSGFSCPVITN------FELELLHSIACKAC-GQVI 455
++ S E + PKQ+ T G P + F L ++ CK C Q
Sbjct: 186 LFDVHSLEQQSEITPKQITC---RTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSP 242
Query: 456 LKTELNNYLSINLPQRIKAHPSSIQSTFDLFFGAEELE----YKCAKCEHK--------- 502
++ + + LS+++P HP ++ F +E + C K E K
Sbjct: 243 VRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVE 302
Query: 503 ----TSVGVHSFSRLPRILIVHLKRYSLNEFCALKKNDQEVIISKYL 545
T V +LP+ L +HL+R S + K + V +++L
Sbjct: 303 HQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFL 349
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 53.9 bits (128), Expect = 7e-07
Identities = 49/190 (25%), Positives = 79/190 (41%), Gaps = 21/190 (11%)
Query: 293 ICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTM----CLARLLFF 348
IC GL NLGNTC+MN+ LQ L ++P + LN + N L M A
Sbjct: 308 IC-GLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLV 366
Query: 349 KDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQL---------KDNME 399
K ++ + ++ K + A F G Q+D+ E L+ LD L K+ +E
Sbjct: 367 KQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVE 426
Query: 400 KLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTE 459
+ +P E ++ + +D ++ F ++ C CG V + +
Sbjct: 427 LCDAAGRPDQEVAQEAWQNHKRRND-------SVIVDTFHGLFKSTLVCPDCGNVSVTFD 479
Query: 460 LNNYLSINLP 469
YLS+ LP
Sbjct: 480 PFCYLSVPLP 489
Score = 37.4 bits (85), Expect = 0.064
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 5/63 (7%)
Query: 472 IKAHPSSIQSTFDLFFGAEELE----YKCAKC-EHKTSVGVHSFSRLPRILIVHLKRYSL 526
+K P +Q +LF E LE + C C +H+ + LP ILI+HLKR+S
Sbjct: 774 MKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSY 833
Query: 527 NEF 529
+F
Sbjct: 834 TKF 836
Score = 37.4 bits (85), Expect = 0.064
Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 4/72 (5%)
Query: 822 HTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIF 881
+ Y LI+V +H G ++ GHY A + + W +DD V + E Q++ Y+
Sbjct: 870 YKYDLIAVSNHYGG-MRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESK---AAYVL 925
Query: 882 FYMHNEIFEEML 893
FY ++ +L
Sbjct: 926 FYQRQDVARRLL 937
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 52.8 bits (125), Expect = 1e-06
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPW--GKIPLNALTMCLARLLFFKDTYN 353
GL N GNTC+MNAV+Q L + A+ L + G+ + L R L+ +
Sbjct: 102 GLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPGRAEVTEQLAALVRALWTR---- 157
Query: 354 IEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNME 399
E L K A+S F GN+Q+DA EFL LD++ +++E
Sbjct: 158 -EYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLE 202
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 50.8 bits (120), Expect = 6e-06
Identities = 44/184 (23%), Positives = 78/184 (42%), Gaps = 10/184 (5%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTM----CLARLLFFKDT 351
GL NLGNTC+MN+ +Q L + P + LN + N L M + K
Sbjct: 261 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQM 320
Query: 352 YNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEF 411
++ + + K + A F G Q D E LA LD L +++ ++ KP +
Sbjct: 321 WSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRK--KPYIQL 378
Query: 412 GE-DNFPKQVFADDPDTSGF---SCPVITNFELELLHSIACKACGQVILKTELNNYLSIN 467
+ D P +V A++ + ++ F ++ C C ++ + + YL++
Sbjct: 379 KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLP 438
Query: 468 LPQR 471
LP +
Sbjct: 439 LPMK 442
Score = 36.6 bits (83), Expect = 0.11
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 4/74 (5%)
Query: 816 NDDKGDHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRR 875
N + G Y LI+V +H G + GHY A + + W+ +DD V E Q+
Sbjct: 838 NPNAGPCRYNLIAVSNHYGG-MGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSK-- 894
Query: 876 CTGYIFFYMHNEIF 889
Y+ FY + F
Sbjct: 895 -AAYVLFYQRQDTF 907
Score = 31.2 bits (69), Expect = 4.6
Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 2/43 (4%)
Query: 488 GAEELEYKCAKC-EHKTSVGVHSFSRLPRILIVHLKRYSLNEF 529
GAE+ Y C C EH+ + LP +L+VHLKR+S + +
Sbjct: 773 GAEDPWY-CPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 50.1 bits (118), Expect = 1e-05
Identities = 61/253 (24%), Positives = 100/253 (39%), Gaps = 42/253 (16%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIE 355
GL NLGNTC+MN ++Q+L P D L+ ++P L + F++ Y+
Sbjct: 79 GLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRC-EMPSPELCLVCEMSSLFRELYSGN 137
Query: 356 IKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDN 415
+ L + A G Q DAHEFL LD L + + G+D
Sbjct: 138 PSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCK------------GDD- 184
Query: 416 FPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRI--- 472
A++P+ +C + F L + C+AC V + +S++LP
Sbjct: 185 --VGKAANNPNHC--NCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSF 240
Query: 473 -------------KAHPSSIQSTFDL---FFGAEEL----EYKCAKCE-HKTSVGVHSFS 511
++H I + D F E L + KC C+ ++ S + +
Sbjct: 241 WPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMN 300
Query: 512 RLPRILIVHLKRY 524
+LP + H KR+
Sbjct: 301 KLPVVACFHFKRF 313
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 48.5 bits (114), Expect = 3e-05
Identities = 56/199 (28%), Positives = 82/199 (41%), Gaps = 41/199 (20%)
Query: 296 GLPNLGNTCYMNAVLQSLLSIPSFADDLL---------------NQSFPWGKIPLNALTM 340
GL N GNTC+MNA LQ L + FA+ L Q G +T
Sbjct: 129 GLRNHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTE 188
Query: 341 CLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLKDNM-- 398
LA L+ + + +E + K +S A + GN+Q+DA EFL LD++ +++
Sbjct: 189 QLAHLV--RALWTLEYTPQHSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNH 246
Query: 399 ---EKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLH-----SIACKA 450
+ KP SE D P+ G S PV + F EL S+ C
Sbjct: 247 SVKQSGQPPLKPPSE--TDMMPE----------GPSFPVCSTFVQELFQAQYRSSLTCPH 294
Query: 451 CGQVILKTELNNYLSINLP 469
C + + +L I+LP
Sbjct: 295 CQK--QSNTFDPFLCISLP 311
Score = 40.4 bits (93), Expect = 0.008
Identities = 24/68 (35%), Positives = 34/68 (50%), Gaps = 8/68 (11%)
Query: 818 DKGDHTYRLISVVSHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRC- 876
D D+ Y L +V +H G T++ GHY + +W+ +DD V Q+ ED C
Sbjct: 701 DPEDYIYDLYAVCNHHG-TMQGGHYTAYCKNSVDGLWYCFDDSDV-----QQLSEDEVCT 754
Query: 877 -TGYIFFY 883
T YI FY
Sbjct: 755 QTAYILFY 762
>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 7/106 (6%)
Query: 290 PEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFK 349
P + GL N+GNTCY+NA LQ L P A+ +L++ +C + +
Sbjct: 75 PAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITR 134
Query: 350 DTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLK 395
+N ++ + A A FH Q DAHEFL +D +K
Sbjct: 135 ALHNPG-------HVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMK 173
>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 7/106 (6%)
Query: 290 PEKICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFK 349
P + GL N+GNTCY+NA LQ L P A+ +L++ +C + +
Sbjct: 75 PAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITR 134
Query: 350 DTYNIEIKEMLLLNLKKAISAAAEIFHGNAQNDAHEFLAHCLDQLK 395
+N ++ + A A FH Q DAHEFL +D +K
Sbjct: 135 ALHNPG-------HVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMK 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,703,113
Number of Sequences: 37866
Number of extensions: 1611241
Number of successful extensions: 5610
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 5260
Number of HSP's gapped (non-prelim): 321
length of query: 913
length of database: 18,247,518
effective HSP length: 111
effective length of query: 802
effective length of database: 14,044,392
effective search space: 11263602384
effective search space used: 11263602384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.