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Search of human proteins with 139394668
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|139394668 TBC1 domain family, member 9 (with GRAM domain)
[Homo sapiens]
(1266 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 2544 0.0
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 1541 0.0
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 1539 0.0
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 1092 0.0
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 1082 0.0
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 684 0.0
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 175 3e-43
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 155 2e-37
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 154 5e-37
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 152 1e-36
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 136 1e-31
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 135 2e-31
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 125 3e-28
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 115 2e-25
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 112 3e-24
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 111 5e-24
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 110 9e-24
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 108 4e-23
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 108 4e-23
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 105 2e-22
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 102 2e-21
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 98 4e-20
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 98 4e-20
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 8e-19
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 8e-19
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 8e-19
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 80 2e-14
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 77 1e-13
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 76 2e-13
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 76 2e-13
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 2544 bits (6593), Expect = 0.0
Identities = 1266/1266 (100%), Positives = 1266/1266 (100%)
Query: 1 MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV 60
MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV
Sbjct: 1 MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV 60
Query: 61 APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ 120
APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ
Sbjct: 61 APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ 120
Query: 121 GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY 180
GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY
Sbjct: 121 GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY 180
Query: 181 LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE 240
LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE
Sbjct: 181 LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE 240
Query: 241 TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR 300
TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR
Sbjct: 241 TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR 300
Query: 301 LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA 360
LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA
Sbjct: 301 LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA 360
Query: 361 DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSD 420
DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSD
Sbjct: 361 DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSD 420
Query: 421 DEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLA 480
DEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLA
Sbjct: 421 DEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNPKLA 480
Query: 481 KEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPG 540
KEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPG
Sbjct: 481 KEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPG 540
Query: 541 YYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYC 600
YYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYC
Sbjct: 541 YYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYC 600
Query: 601 QAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQL 660
QAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQL
Sbjct: 601 QAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQL 660
Query: 661 YDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK 720
YDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK
Sbjct: 661 YDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK 720
Query: 721 LLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEK 780
LLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEK
Sbjct: 721 LLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEK 780
Query: 781 FGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLT 840
FGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLT
Sbjct: 781 FGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLT 840
Query: 841 SCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDE 900
SCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDE
Sbjct: 841 SCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDE 900
Query: 901 NGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDI 960
NGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDI
Sbjct: 901 NGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDI 960
Query: 961 TPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKD 1020
TPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKD
Sbjct: 961 TPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKNAKD 1020
Query: 1021 LPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGS 1080
LPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGS
Sbjct: 1021 LPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGS 1080
Query: 1081 GGSGPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSP 1140
GGSGPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSP
Sbjct: 1081 GGSGPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQMEDIKLEDSSP 1140
Query: 1141 RDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALP 1200
RDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALP
Sbjct: 1141 RDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVRSGQGTAALP 1200
Query: 1201 RSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYE 1260
RSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYE
Sbjct: 1201 RSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGKPLTSASDYE 1260
Query: 1261 ISAMSG 1266
ISAMSG
Sbjct: 1261 ISAMSG 1266
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform
b [Homo sapiens]
Length = 1233
Score = 1541 bits (3989), Expect = 0.0
Identities = 801/1275 (62%), Positives = 958/1275 (75%), Gaps = 51/1275 (4%)
Query: 1 MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV 60
MW++PEEVL+ANALW+TERANP+F+LQRR+GH G GGGL GLLVGTLDVVLDSSARV
Sbjct: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGH----GRGGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ 120
APYRIL+QT DS VYWT+ACG SRKEIT+HWEWLE NLLQTLSIF++E DITTFV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY 180
GIIAE NK + D+D KFKEA +K + FGMPE EKLVNYYSCSYWKG+VPRQGW+Y
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 181 LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE 240
L++NHLCFYSFL+G+E LV++WVDIT+LEKNATLL P+ I+V TR E FFS+FLNI E
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 241 TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR 300
TFKLMEQLAN+AMRQLLD+EGF +D++LP+ R + +SALKRDLDARAK+E YRA FR
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPH-RNISALKRDLDARAKNECYRATFR 295
Query: 301 LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA 360
LP+DE+LDGHT CTLWTPFNK+HI GQMF+S NYICF SKEE+ C LIIPLREVTIVEKA
Sbjct: 296 LPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKA 355
Query: 361 DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSS- 419
DSSSVLPSPLSIST+++MTFLFANLKDRDFLVQRISDFLQ+T SK GS +S
Sbjct: 356 DSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSK---QPGSIGSRKASV 412
Query: 420 -DDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSP-EEFNP 477
D S P+ S S +S + F PTA+Q L+ ++++ SP E+
Sbjct: 413 VDPSTESSPAPQEGSEQPASPASPLSSRQSFC--AQEAPTASQGLLKLFQKNSPMEDLGA 470
Query: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
K AKE +KE++W IHF EYG+G+CMYRT KTR LVLKGIPES+RGELWLL SGA NE T
Sbjct: 471 KGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT 530
Query: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
HPGYY +LVEKS GKY+LATEEIERDLHRS+PEHPAFQNE+GIAALRRVLTAYAFRNP I
Sbjct: 531 HPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTI 590
Query: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYV 657
GYCQAMNIVTSVLLLY EEEAFWLLVALCERMLPDYYNTRVVGALVDQG+FEEL RD++
Sbjct: 591 GYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFL 650
Query: 658 PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDAN 717
PQL + MQDLGVIS+ISLSWFLTLFLSVMPFESAVV+VDCFFYEGIKVI Q+ALAVLDAN
Sbjct: 651 PQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDAN 710
Query: 718 VDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTS 777
+++LL C D+GEAMT+LGRYLD+V NK S PPIPHL +LLS +P EVDIF L++ S
Sbjct: 711 MEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVS 770
Query: 778 YEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAE 837
YEKF ++RA+ IEQMRFKQRLKVIQ+LEDT KR+VVR I + F+I+ELE+LY +FKA+
Sbjct: 771 YEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAK 830
Query: 838 HLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQL 897
HL S YWG S R DPSLPYLEQYRID QF+ +FA L PWACG+H+ +LA R+F+L
Sbjct: 831 HLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRL 890
Query: 898 LDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFF 957
LDEN DSLINF+EFV+G+S HGDLTEKLK+LYK+H+ P+ +E +SA EA YF
Sbjct: 891 LDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHL--PPALSPEEAESALEAAHYFT 948
Query: 958 EDITPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKSKSKN 1017
ED + E L ++G+ S + + K +S + R+YLR+W E +++ +
Sbjct: 949 EDSSSE----EALPQEEQEGSG------SEERGEEKGTSSPDYRHYLRMWAKEKEAQKET 998
Query: 1018 AKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQPAKE 1077
KDLPK+NQ QFIELCKT+YNMFSEDP EQ+LYHA A V SLLL IGEVGK F A+ ++
Sbjct: 999 IKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRK 1058
Query: 1078 GGSGGS------GPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEHSLGGQME 1131
+ P HQ L P P + A Q
Sbjct: 1059 PRDCATEEDEPPAPELHQDAARELQPPAAGD-----------PQAKAGGDTHLGKAPQES 1107
Query: 1132 DIKLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIGEDTVLVR 1191
+ +E S G+ S L+SDD+TKDD SMSSYSV+S GS L CED+ +DTVLV
Sbjct: 1108 QVVVEGGSGEGQGS-PSQLLSDDETKDDMSMSSYSVVSTGS-----LQCEDLADDTVLVG 1161
Query: 1192 SGQGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAKNIRMMGK 1251
+ ++D DW I+FEQ LAS+LTE LV +F+K V + +I K + +
Sbjct: 1162 GEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVE---R 1218
Query: 1252 PLTSASDYEISAMSG 1266
++ASD+E +SG
Sbjct: 1219 QFSTASDHEQPGVSG 1233
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1250
Score = 1539 bits (3984), Expect = 0.0
Identities = 801/1282 (62%), Positives = 960/1282 (74%), Gaps = 48/1282 (3%)
Query: 1 MWVNPEEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARV 60
MW++PEEVL+ANALW+TERANP+F+LQRR+GH G GGGL GLLVGTLDVVLDSSARV
Sbjct: 1 MWLSPEEVLVANALWVTERANPFFVLQRRRGH----GRGGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGKIQ 120
APYRIL+QT DS VYWT+ACG SRKEIT+HWEWLE NLLQTLSIF++E DITTFV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGWMY 180
GIIAE NK + D+D KFKEA +K + FGMPE EKLVNYYSCSYWKG+VPRQGW+Y
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 181 LSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINE 240
L++NHLCFYSFL+G+E LV++WVDIT+LEKNATLL P+ I+V TR E FFS+FLNI E
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 241 TFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR 300
TFKLMEQLAN+AMRQLLD+EGF +D++LP+ R + +SALKRDLDARAK+E YRA FR
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPH-RNISALKRDLDARAKNECYRATFR 295
Query: 301 LPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA 360
LP+DE+LDGHT CTLWTPFNK+HI GQMF+S NYICF SKEE+ C LIIPLREVTIVEKA
Sbjct: 296 LPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKA 355
Query: 361 DSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSS- 419
DSSSVLPSPLSIST+++MTFLFANLKDRDFLVQRISDFLQ+T SK GS +S
Sbjct: 356 DSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSK---QPGSIGSRKASV 412
Query: 420 -DDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSP-EEFNP 477
D S P+ S S +S + F PTA+Q L+ ++++ SP E+
Sbjct: 413 VDPSTESSPAPQEGSEQPASPASPLSSRQSFC--AQEAPTASQGLLKLFQKNSPMEDLGA 470
Query: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
K AKE +KE++W IHF EYG+G+CMYRT KTR LVLKGIPES+RGELWLL SGA NE T
Sbjct: 471 KGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVT 530
Query: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
HPGYY +LVEKS GKY+LATEEIERDLHRS+PEHPAFQNE+GIAALRRVLTAYAFRNP I
Sbjct: 531 HPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTI 590
Query: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYV 657
GYCQAMNIVTSVLLLY EEEAFWLLVALCERMLPDYYNTRVVGALVDQG+FEEL RD++
Sbjct: 591 GYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFL 650
Query: 658 PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDAN 717
PQL + MQDLGVIS+ISLSWFLTLFLSVMPFESAVV+VDCFFYEGIKVI Q+ALAVLDAN
Sbjct: 651 PQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDAN 710
Query: 718 VDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTS 777
+++LL C D+GEAMT+LGRYLD+V NK S PPIPHL +LLS +P EVDIF L++ S
Sbjct: 711 MEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVS 770
Query: 778 YEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAE 837
YEKF ++RA+ IEQMRFKQRLKVIQ+LEDT KR+VVR I + F+I+ELE+LY +FKA+
Sbjct: 771 YEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAK 830
Query: 838 HLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQL 897
HL S YWG S R DPSLPYLEQYRID QF+ +FA L PWACG+H+ +LA R+F+L
Sbjct: 831 HLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRL 890
Query: 898 LDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFF 957
LDEN DSLINF+EFV+G+S HGDLTEKLK+LYK+H+ P+ +E +SA EA YF
Sbjct: 891 LDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHL--PPALSPEEAESALEAAHYFT 948
Query: 958 EDITPECTHVVG-----LDSRSKQGADDGFVTVSLKPDKG--KRANSQENRNYLRLWTPE 1010
ED + E + + L +++ S ++G K +S + R+YLR+W E
Sbjct: 949 EDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKE 1008
Query: 1011 NKSKSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLF 1070
+++ + KDLPK+NQ QFIELCKT+YNMFSEDP EQ+LYHA A V SLLL IGEVGK F
Sbjct: 1009 KEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKF 1068
Query: 1071 VAQPAKEGGSGGS------GPSCHQGIPGVLFPKKGPGQPYVVESVEPLPASLAPDSEEH 1124
A+ ++ + P HQ L P P + A
Sbjct: 1069 SARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGD-----------PQAKAGGDTHL 1117
Query: 1125 SLGGQMEDIKLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSAGSHEEDKLHCEDIG 1184
Q + +E S G+ S L+SDD+TKDD SMSSYSV+S GS L CED+
Sbjct: 1118 GKAPQESQVVVEGGSGEGQGS-PSQLLSDDETKDDMSMSSYSVVSTGS-----LQCEDLA 1171
Query: 1185 EDTVLVRSGQGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAK 1244
+DTVLV + ++D DW I+FEQ LAS+LTE LV +F+K V + +I K
Sbjct: 1172 DDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1231
Query: 1245 NIRMMGKPLTSASDYEISAMSG 1266
+ + ++ASD+E +SG
Sbjct: 1232 KVE---RQFSTASDHEQPGVSG 1250
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 1092 bits (2823), Expect = 0.0
Identities = 560/1101 (50%), Positives = 752/1101 (68%), Gaps = 71/1101 (6%)
Query: 1 MWVNPEEVLLANAL--WITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSA 58
MW+ PEEVLL NAL W+T++++ YFILQRR+GH G GGG L G LVG LD VLDS+A
Sbjct: 1 MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGH---GEGGGRLTGRLVGALDAVLDSNA 57
Query: 59 RVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGK 118
RVAP+RIL Q P S VY IACG + +EI +HW+WLEQNLL TLS+F+N++DI +FV+GK
Sbjct: 58 RVAPFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGK 117
Query: 119 IQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGW 178
++ +IAE +++++ EKF+EA+VKF F PE EKLV YYSC WKG+VPRQGW
Sbjct: 118 VKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGW 177
Query: 179 MYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNI 238
+YLSINHLCFYSF +G+E KLV+ WVDI +LE+ + + L D I+++T++ E FS+FLN+
Sbjct: 178 LYLSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNL 237
Query: 239 NETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRAL 298
+E FK+MEQLA++ +R+LLDNE F+ D L + P +++ KRDL+ARA++E +RA
Sbjct: 238 DEVFKVMEQLADVTLRRLLDNEVFDLDPDL-----QEPSQIT--KRDLEARAQNEFFRAF 290
Query: 299 FRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358
FRLP+ EKL DC+LWTPF++ H G+MF S +YICF S+E+ C +I+PLREV +E
Sbjct: 291 FRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIE 350
Query: 359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSK--IYSDKEFAGSY 416
K + +S+LP P+ +S R+++ F F L+DRD LV+ + L+Q + ++ D
Sbjct: 351 KMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYD------- 403
Query: 417 NSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQ--------TLMTMYR 468
S+DD++ +SLV S S G+ + + NS + + L+T ++
Sbjct: 404 TSADDDM----ASLVFHSTSMC-SDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQ 458
Query: 469 RRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLL 528
+ + + ++++E +K W HF EYG+ +CM+RTEK R+LV GIPES+RG LWLL
Sbjct: 459 QSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLF 518
Query: 529 SGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLT 588
S A+ + A+HPGYY +LVE+S+GK L TEEIERDLHRSLPEHPAFQNE GIAALRRVLT
Sbjct: 519 SDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLT 578
Query: 589 AYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGV 648
AYA RNP IGYCQ+MNI+TSVLLLY KEEEAFWLLVA+CERMLPDY+N RV+GA VDQ V
Sbjct: 579 AYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSV 638
Query: 649 FEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQ 708
FEEL + ++P+L + M DL ++++SLSWFLTLFLS+MP ESAV VVDCFFY+GIK IFQ
Sbjct: 639 FEELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQ 698
Query: 709 LALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEV 768
L LAVL+AN + L + KDDG+A+ +L R+LD + N+DS PP+ H+ SDD EPYP
Sbjct: 699 LGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVT 758
Query: 769 DIFRLIRTSYEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELE 828
DI LIR SYEKFG + IE +R+K R++V+Q EDTTK+NV+R ++ E S ++LE
Sbjct: 759 DISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLE 818
Query: 829 ELYALFKAEHLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSD 888
ELY LFK EH+ SCYW RHDPS PY EQYRID QF +F L+ PW CG H++
Sbjct: 819 ELYDLFKREHMMSCYWEQPRPMASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTE 878
Query: 889 VLASRLFQLLDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSSDQDEPDS 948
+LA R F+LLD+N D LI F+ FVS L +G++ EK+KLLY++H+ P+ +++ DS
Sbjct: 879 ILAERTFRLLDDNMDQLIEFKAFVSCLDIMYNGEMNEKIKLLYRLHI--PPALTENDRDS 936
Query: 949 AFEATQYFFEDITPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWT 1008
P V KP+ G + Q + ++
Sbjct: 937 QSPLRNPLLSTSRP---------------------LVFGKPN-GDAVDYQ--KQLKQMIK 972
Query: 1009 PENKSKSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGK 1068
K K K K+LPK++Q +FI+ CKT+Y+MF EDP E +LY A A VT+LLL+IGEVG+
Sbjct: 973 DLAKEKDKTEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQ 1032
Query: 1069 LFVAQPAKEGGSGGSGPSCHQ 1089
G S SC Q
Sbjct: 1033 -----------RGSSSGSCSQ 1042
Score = 51.2 bits (121), Expect = 6e-06
Identities = 30/85 (35%), Positives = 50/85 (58%), Gaps = 9/85 (10%)
Query: 1185 EDTVLVRSG---QGTAALPRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARIT 1241
ED+V +G Q + A P + +RDW ++ E LASLLTE +LV +F+KP+ M +++
Sbjct: 1056 EDSVFADTGKTPQDSQAFPEAA--ERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLE 1113
Query: 1242 SAK----NIRMMGKPLTSASDYEIS 1262
+AK N++ S S+ ++S
Sbjct: 1114 NAKINQYNLKTFEMSHQSQSELKLS 1138
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1120
Score = 1082 bits (2799), Expect = 0.0
Identities = 572/1099 (52%), Positives = 751/1099 (68%), Gaps = 53/1099 (4%)
Query: 1 MWVNPEEVLLANAL--WITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSA 58
MW+ PEEVLL NAL W+ ER+N YF+LQRR+G+ +GGGG L GLLVGTLD VLDS+A
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGG--LTGLLVGTLDSVLDSTA 58
Query: 59 RVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGK 118
+VAP+RIL+QTPDS VY +IACG +R+EIT+HW+WLEQN+++TLS+F++ DIT FV+GK
Sbjct: 59 KVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGK 118
Query: 119 IQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGW 178
I+G+IAE K KEDD EKF+EA++KF + FG+PE+EKLV YYSCSYWKG+VP QGW
Sbjct: 119 IRGLIAEEGKHCFAKEDDP-EKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGW 177
Query: 179 MYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNI 238
+YLS N L FYSFL+G E KL+I W ++++LEK + ++L + I V ++ H+FS+FL+I
Sbjct: 178 LYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHI 237
Query: 239 NETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRAL 298
N+T+ LMEQLAN A+R+L D E F+ D L +P +++ KR L+ RA SE++ A
Sbjct: 238 NQTYLLMEQLANYAIRRLFDKETFDNDPVL-----YNPLQIT--KRGLENRAHSEQFNAF 290
Query: 299 FRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358
FRLPK E L +C LW PF+ + G+M +S NYICF S++ N CS+IIPLREV ++
Sbjct: 291 FRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAID 350
Query: 359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYS-DKEFAGSYN 417
K + SS + IS + + F F +KD + LV ++ +++ + E A S
Sbjct: 351 KTNDSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSE 407
Query: 418 SSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNP 477
S++ SL S QR S + T+ LMT++ ++ E N
Sbjct: 408 STEPSDNFEVQSLTS---QRECSKTVN---------------TEALMTVFHPQNLETLNS 449
Query: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
K+ KE +KEQ+WKI FAE G+G+ M+RT+KTR+LV++GIPE++RGELW+L SGA+N+ AT
Sbjct: 450 KMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAT 509
Query: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
+P YY ++VE+S+G NLATEEIERDL RSLPEHPAFQ++ GI+ALRRVLTAYA+RNP I
Sbjct: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 569
Query: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYV 657
GYCQAMNI+TSVLLLYAKEEEAFWLLVA+CERMLPDY+N R++GALVDQ VFEEL RD++
Sbjct: 570 GYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHL 629
Query: 658 PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDAN 717
PQL + M D+ S++SLSWFLTLF+SV+P ESAV VVDCFFY+GIK I QL LA+LD N
Sbjct: 630 PQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYN 689
Query: 718 VDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTS 777
+DKLL CKDD EA+T L R+ D+VTNKDS LP S +SD+ + VDI LIR S
Sbjct: 690 LDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRES 749
Query: 778 YEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAE 837
EK+G IR + I MR + RL VIQTLE+TTK+NV+R + + ++ EL+ELY +FK E
Sbjct: 750 NEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKE 809
Query: 838 HLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQL 897
SCYW L HDPSLPYLEQY+ID +QF+ ++ LL PWA + D LA F+L
Sbjct: 810 LFLSCYWCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRL 869
Query: 898 LDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPE----PSSDQDEPDSAFEAT 953
LDEN D LINF+EF S + +G TEKLKLL+K+H+ P S D + D +
Sbjct: 870 LDENSDCLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEE 929
Query: 954 QYFFEDITPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKS 1013
+F + HV SK + + P+KGK + + YL W E
Sbjct: 930 LLYFSQL-----HV------SKPANEKEAESAKHSPEKGK--GKIDIQAYLSQWQDELFK 976
Query: 1014 KSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQ 1073
K +N KDLP++NQ QFI+ KT+YN+F EDP E+ LY A A VTSLLL + EVG+
Sbjct: 977 KEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKL--H 1034
Query: 1074 PAKEGGSGGSGPSCHQGIP 1092
G SG C G P
Sbjct: 1035 SPTSSAKGFSGTVCGSGGP 1053
Score = 48.1 bits (113), Expect = 5e-05
Identities = 21/45 (46%), Positives = 32/45 (71%)
Query: 1200 PRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAK 1244
P S + W+ FEQ LASLL EPALV++F+KP+ + A++ +A+
Sbjct: 1066 PCSFREEPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENAR 1110
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 684 bits (1765), Expect = 0.0
Identities = 350/645 (54%), Positives = 470/645 (72%), Gaps = 34/645 (5%)
Query: 1 MWVNPEEVLLANAL--WITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSA 58
MW+ PEEVLL NAL W+ ER+N YF+LQRR+G+ +GGGG L GLLVGTLD VLDS+A
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGG--LTGLLVGTLDSVLDSTA 58
Query: 59 RVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGK 118
+VAP+RIL+QTPDS VY +IACG +R+EIT+HW+WLEQN+++TLS+F++ DIT FV+GK
Sbjct: 59 KVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGK 118
Query: 119 IQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGW 178
I+G+IAE K KEDD EKF+EA++KF + FG+PE+EKLV YYSCSYWKG+VP QGW
Sbjct: 119 IRGLIAEEGKHCFAKEDDP-EKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGW 177
Query: 179 MYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNI 238
+YLS N L FYSFL+G E KL+I W ++++LEK + ++L + I V ++ H+FS+FL+I
Sbjct: 178 LYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHI 237
Query: 239 NETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRAL 298
N+T+ LMEQLAN A+R+L D E F+ D L +P +++ KR L+ RA SE++ A
Sbjct: 238 NQTYLLMEQLANYAIRRLFDKETFDNDPVL-----YNPLQIT--KRGLENRAHSEQFNAF 290
Query: 299 FRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358
FRLPK E L +C LW PF+ + G+M +S NYICF S++ N CS+IIPLREV ++
Sbjct: 291 FRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAID 350
Query: 359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYS-DKEFAGSYN 417
K + SS + IS + + F F +KD + LV ++ +++ + E A S
Sbjct: 351 KTNDSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSE 407
Query: 418 SSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNP 477
S++ SL S QR S + T+ LMT++ ++ E N
Sbjct: 408 STEPSDNFEVQSLTS---QRECSKTVN---------------TEALMTVFHPQNLETLNS 449
Query: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
K+ KE +KEQ+WKI FAE G+G+ M+RT+KTR+LV++GIPE++RGELW+L SGA+N+ AT
Sbjct: 450 KMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAT 509
Query: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
+P YY ++VE+S+G NLATEEIERDL RSLPEHPAFQ++ GI+ALRRVLTAYA+RNP I
Sbjct: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 569
Query: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGA 642
GYCQAMNI+TSVLLLYAKEEEAFWLLVA+CERMLPDY+N R++G+
Sbjct: 570 GYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGS 614
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 175 bits (443), Expect = 3e-43
Identities = 96/265 (36%), Positives = 152/265 (57%), Gaps = 4/265 (1%)
Query: 500 ICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE 559
+ + R+EK R LVL GIP MR +LW+ LSGA+ +K Y ++V+ S +A ++
Sbjct: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
Query: 560 IERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEE 617
IE+DL R++P + F +G+ LRRVL A A+ P IGYCQ +V + LLL+ +EE
Sbjct: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
Query: 618 EAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISL 675
+AFW++ A+ E +LP Y++T ++G DQ V L Y+P+L +Q+ + +S I+L
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
Query: 676 SWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLG 735
WFLT F SV+ + + + D FFYEG +V+FQL L +L ++L+ ++ L
Sbjct: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
Query: 736 RYLDSVTNKDSTLPPIPHLHSLLSD 760
+ + + L L L+D
Sbjct: 339 DIPSQMEDAELLLGVAMRLAGSLTD 363
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 155 bits (393), Expect = 2e-37
Identities = 99/285 (34%), Positives = 160/285 (56%), Gaps = 15/285 (5%)
Query: 489 WKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKA---THPGYYEDL 545
W+ +FA M E + L+ GIP R ++W K T PG+++ L
Sbjct: 637 WENYFASTVNREMMCSPE-LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTL 695
Query: 546 VEKSMGKYNLATEEIERDLHRSLP--EHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAM 603
++K++ K N A+++IE DL R+LP +H + GI LR VL A+++RNP+IGYCQ +
Sbjct: 696 LQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGL 755
Query: 604 NIVTSVLLLYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYD 662
N + +V LLY ++E+AFW LV + E +P DYY ++G+ VDQ VF +L + +P+L+
Sbjct: 756 NRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
Query: 663 CMQDLGVIST-ISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKL 721
+ V T I+ +WFL +F+ + + + D F YEG KVIF+ ALA+ +++
Sbjct: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
Query: 722 LNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYP 766
L +D +M++ +YL T T+ L S+ D+ P+P
Sbjct: 876 LKLQD---SMSIF-KYLRYFTR---TILDARKLISISFGDLNPFP 913
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 154 bits (389), Expect = 5e-37
Identities = 93/267 (34%), Positives = 146/267 (54%), Gaps = 14/267 (5%)
Query: 467 YRRRSPEEFNPKLAKEFLKEQAWK-----IHFAEYGQGICMYRTEKTRELVLKGIPESMR 521
Y PE+F+ ++F I ++ QG + R+ + V KG+P R
Sbjct: 15 YGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRTVKRYVRKGVPLEHR 74
Query: 522 GELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE-IERDLHRSLPEHPAFQNEMGI 580
+W++LSGA + +PGYY L++ G+ N E+ I DL+R+ P++ F+
Sbjct: 75 ARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTDP 131
Query: 581 AALR---RVLTAYAFRNPNIGYCQAMNIVTSVLLLYAK-EEEAFWLLVALCERMLPDYYN 636
R VL AY N +GYCQ MN + L+L EEE+FWLL AL R+LPDYY+
Sbjct: 132 CLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYYS 191
Query: 637 TRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS-WFLTLFLSVMPFESAVVVV 695
++G DQ V EL R +P + M+ LGV+ T+ +S WF+ LF+ ++P E+ + +
Sbjct: 192 PAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIW 251
Query: 696 DCFFYEGIKVIFQLALAVLDANVDKLL 722
DC F EG K+IF++AL ++ + + +L
Sbjct: 252 DCLFNEGSKIIFRVALTLIKQHQELIL 278
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 152 bits (385), Expect = 1e-36
Identities = 89/245 (36%), Positives = 142/245 (57%), Gaps = 8/245 (3%)
Query: 489 WKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKA---THPGYYEDL 545
W+ +FA M E + L+ GIP R ++W K T PG+++ L
Sbjct: 637 WENYFASTVNREMMCSPE-LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTL 695
Query: 546 VEKSMGKYNLATEEIERDLHRSLP--EHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAM 603
++K++ K N A+++IE DL R+LP +H + GI LR VL A+++RNP+IGYCQ +
Sbjct: 696 LQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGL 755
Query: 604 NIVTSVLLLYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYD 662
N + +V LLY ++E+AFW LV + E +P DYY ++G+ VDQ VF +L + +P+L+
Sbjct: 756 NRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
Query: 663 CMQDLGVIST-ISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKL 721
+ V T I+ +WFL +F+ + + + D F YEG KVIF+ ALA+ +++
Sbjct: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
Query: 722 LNCKD 726
L +D
Sbjct: 876 LKLQD 880
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 136 bits (343), Expect = 1e-31
Identities = 83/233 (35%), Positives = 118/233 (50%), Gaps = 6/233 (2%)
Query: 485 KEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYED 544
+E W + + + R +K + KGIP ++R W LL GA + PG Y++
Sbjct: 63 REMKW-VEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQE 121
Query: 545 LVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQA 602
L E + T I RDLHR P H F + G L +VL AY P GYCQA
Sbjct: 122 LAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQA 179
Query: 603 MNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
V +VLL++ EEAFW LV +CE LP YY + +D VF L R +P ++
Sbjct: 180 QGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHK 239
Query: 663 CMQDLGVISTISL-SWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVL 714
+Q +GV + L WFL LF +PF + + V D F EG +V+F++ L ++
Sbjct: 240 HLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 135 bits (340), Expect = 2e-31
Identities = 99/332 (29%), Positives = 163/332 (49%), Gaps = 20/332 (6%)
Query: 485 KEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYED 544
+E W F+ + + + R +K + KGIP S+R + W LS + +PG +E+
Sbjct: 331 RELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEE 389
Query: 545 LVEKSMGKYNLATEEIERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQA 602
L E++ G + IE+DLHR P H F + G L R+L AY P+ GYCQA
Sbjct: 390 L-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQA 447
Query: 603 MNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
V +VLL++ E+AFW LV +C++ LP YY+ + +D +F L R P +
Sbjct: 448 QAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHR 507
Query: 663 CMQDLGVISTISLS-WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLD---ANV 718
++ + + ++ WF+ +F +P+ S + V D FF EG+K+IF++AL +L +V
Sbjct: 508 HLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSV 567
Query: 719 DKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSY 778
+KL +C+ E M L +D + + +L P E I R
Sbjct: 568 EKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNL---------PVTEALIERENAAQL 618
Query: 779 EKFGTIRADLIEQMRFKQRLKVIQTLEDTTKR 810
+K+ R +L Q R +RL + + + +R
Sbjct: 619 KKWRETRGEL--QYRPSRRLHGSRAIHEERRR 648
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 125 bits (314), Expect = 3e-28
Identities = 75/212 (35%), Positives = 113/212 (53%), Gaps = 5/212 (2%)
Query: 506 EKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLH 565
+K R KGIP S+RG W LSG + +PG +++L + S G + IERDLH
Sbjct: 102 KKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDEL-DMSPGDPKWL-DVIERDLH 159
Query: 566 RSLPEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLL 623
R P H F + G L RVL AY P GYCQA + +VLL++ E+AFW L
Sbjct: 160 RQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCL 219
Query: 624 VALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS-WFLTLF 682
V +CE+ LP YY+ ++ +D + L + P + + + + ++ WF+ F
Sbjct: 220 VQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAF 279
Query: 683 LSVMPFESAVVVVDCFFYEGIKVIFQLALAVL 714
+P+ S + V D FF EG+K+IF++ L +L
Sbjct: 280 SRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLL 311
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 115 bits (289), Expect = 2e-25
Identities = 70/204 (34%), Positives = 112/204 (54%), Gaps = 11/204 (5%)
Query: 509 RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSL 568
++L+ G+P R +W L + PG Y++L+ + + + A +IE DL+R+
Sbjct: 619 KQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTF 678
Query: 569 PEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEE-AFWLLVA 625
P + F LRRVL A++++NP IGYCQ +N + ++ LL +EEE AFW LVA
Sbjct: 679 PNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVA 738
Query: 626 LCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGV----ISTISLSWFLT 680
+ E ++P DYY + + VDQ V ++L + +P+L M LG +S ++ +WFL
Sbjct: 739 IVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRL---MAHLGQHHVDLSLVTFNWFLV 795
Query: 681 LFLSVMPFESAVVVVDCFFYEGIK 704
+F + + V D F YEG K
Sbjct: 796 VFADSLISNILLRVWDAFLYEGTK 819
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 112 bits (279), Expect = 3e-24
Identities = 74/226 (32%), Positives = 118/226 (52%), Gaps = 15/226 (6%)
Query: 504 RTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKS---MGKYNLATEEI 560
R ++ LV G+PE++RGE+W LL+G N + LVEK + K + I
Sbjct: 555 RPKQLSSLVRNGVPEALRGEVWQLLAGCHNN--------DHLVEKYRILITKESPQDSAI 606
Query: 561 ERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEE 618
RD++R+ P H F++ G +L ++ AY+ + IGYCQ + + +VLLL+ EE+
Sbjct: 607 TRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ 666
Query: 619 AFWLLVALC-ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS- 676
AF +LV + + L + + E L ++Y+P LY+ D+ + + + S
Sbjct: 667 AFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQ 726
Query: 677 WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 722
WFLTLF + P ++D EGI VIF +AL +L + D LL
Sbjct: 727 WFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL 772
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 111 bits (277), Expect = 5e-24
Identities = 98/396 (24%), Positives = 177/396 (44%), Gaps = 33/396 (8%)
Query: 376 NRMTFLFANLKDRDFLVQRISDFLQQTTSKI-----YSDKEFAGSYNSSDDEVYSRPSSL 430
N+MT F N + ++++ L T S + ++ + A S +++ SS
Sbjct: 4 NKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSST 63
Query: 431 VSSSPQRSTSS-------DADGERQFNLNGNSVPTATQTLMTMY--RRRSPEEFNPKLAK 481
S+P S SS D + + + T +++L ++ RR S +
Sbjct: 64 TLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSA 123
Query: 482 E----FLKEQAWKI--HFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEK 535
L+E +W + + + + ++ +ELV KGIP R +W LL A +
Sbjct: 124 SSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSA--QS 181
Query: 536 ATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFR 593
Y +L++ + L I RD+ R+ PEH F+ + +G L V+ AY+
Sbjct: 182 MPIKDQYSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLV 237
Query: 594 NPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERM-LPDYYNTRVVGALVDQGVFEEL 652
+ +GYCQ + +LL+ EEEAF + V L + L + + + + FE +
Sbjct: 238 DREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECM 297
Query: 653 ARDYVPQLYDCMQDLGV-ISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLAL 711
++++P+L+ Q S + SWFLT+FL+ P A + D F EG++++F++ L
Sbjct: 298 IQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGL 357
Query: 712 AVLDANVDKLLNCKDDG---EAMTVLGRYLDSVTNK 744
A+L N +L+ +G V+ D V +K
Sbjct: 358 ALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDK 393
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 110 bits (275), Expect = 9e-24
Identities = 71/222 (31%), Positives = 117/222 (52%), Gaps = 9/222 (4%)
Query: 511 LVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPE 570
LV G+PE++R E+W LL+G + +A Y L+ K + ++ T RD+HR+ P
Sbjct: 534 LVKSGVPEALRAEVWQLLAGCHDNQAMLDRY-RILITKDSAQESVIT----RDIHRTFPA 588
Query: 571 HPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALC- 627
H F++ G +L ++ AY+ + +IGYCQ + + +VLLL+ EE+AF +LV +
Sbjct: 589 HDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMY 648
Query: 628 ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS-WFLTLFLSVM 686
+ L D Y E L ++ +P L+ DL + + + S WFLTLF +
Sbjct: 649 DYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKF 708
Query: 687 PFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDG 728
P ++D EG+ +IF +ALA+L + + LL +G
Sbjct: 709 PLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEG 750
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 108 bits (269), Expect = 4e-23
Identities = 81/251 (32%), Positives = 126/251 (50%), Gaps = 18/251 (7%)
Query: 504 RTEKT-RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIER 562
R EK +EL+ KGIP R +W LL A + + Y +L++ S L I R
Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRR 156
Query: 563 DLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAF 620
D+ R+ PEH F Q+ +G L V+ AY+ + +GYCQ + +LL+ EEEAF
Sbjct: 157 DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 216
Query: 621 WLLVALC-ERMLPDYYNTRV--VGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISLS 676
+ V L E L + + + +G + Q FE + ++ +P L + S + S
Sbjct: 217 CVFVRLMQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASS 274
Query: 677 WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA---MTV 733
WFLTLFL+ P A V D F YEG++++F++ LA+L N +L+ +G + V
Sbjct: 275 WFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRV 334
Query: 734 LGRYLDSVTNK 744
+ DS +K
Sbjct: 335 IPHQFDSCPDK 345
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 108 bits (269), Expect = 4e-23
Identities = 81/251 (32%), Positives = 126/251 (50%), Gaps = 18/251 (7%)
Query: 504 RTEKT-RELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIER 562
R EK +EL+ KGIP R +W LL A + + Y +L++ S L I R
Sbjct: 103 RKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ--YSELLKMSSPCEKL----IRR 156
Query: 563 DLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAF 620
D+ R+ PEH F Q+ +G L V+ AY+ + +GYCQ + +LL+ EEEAF
Sbjct: 157 DIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 216
Query: 621 WLLVALC-ERMLPDYYNTRV--VGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISLS 676
+ V L E L + + + +G + Q FE + ++ +P L + S + S
Sbjct: 217 CVFVRLMQEYRLRELFKPSMAELGLCIYQ--FEYMLQEQLPDLNTHFRSQSFHTSMYASS 274
Query: 677 WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA---MTV 733
WFLTLFL+ P A V D F YEG++++F++ LA+L N +L+ +G + V
Sbjct: 275 WFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRV 334
Query: 734 LGRYLDSVTNK 744
+ DS +K
Sbjct: 335 IPHQFDSCPDK 345
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 105 bits (263), Expect = 2e-22
Identities = 89/334 (26%), Positives = 159/334 (47%), Gaps = 22/334 (6%)
Query: 489 WKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYE--DLV 546
W+ + G+ + EK V +G+P RGE+W L+ + K P + D+
Sbjct: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
Query: 547 EKSMGKYNLATEE-IERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAM 603
K + K + + I DL R+ P HP F ++G +L +L AY+ + +GYCQ +
Sbjct: 834 YKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGL 893
Query: 604 NIVTSVLLLYAKEEEAFWLLVALCERM-LPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
+ V +LLL+ EEEAF +L L M L Y ++ + L DY LY+
Sbjct: 894 SFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYN 953
Query: 663 CMQDLGV-ISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKL 721
+++ + S + WFLT+F S P V D F +G +VIF++AL++L ++ +
Sbjct: 954 HLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLI 1013
Query: 722 LNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSYEKF 781
L ++ L +D + STLP + + + + E+DI + ++ ++
Sbjct: 1014 LQHEN-------LETIVDFI---KSTLPNLGLVQ--MEKTINQVFEMDIAKQLQAYEVEY 1061
Query: 782 GTIRADLIEQ--MRFKQRL-KVIQTLEDTTKRNV 812
++ +LI+ + QR+ K+ +T K+N+
Sbjct: 1062 HVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNL 1095
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 102 bits (255), Expect = 2e-21
Identities = 98/370 (26%), Positives = 162/370 (43%), Gaps = 34/370 (9%)
Query: 506 EKTRELVLKGIPESMRGELW--LLLSGAINEKATHPGYYEDLVEKSMGKYNLATEE-IER 562
E L+ +G+P+S RGE+W L L + + + D+ K + K A + I
Sbjct: 909 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILV 968
Query: 563 DLHRSLPEHPAFQNEMGIAALR--RVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAF 620
DL R+ P HP F ++G L +L AY+ + +GYCQ ++ V VLLL+ EE+AF
Sbjct: 969 DLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAF 1028
Query: 621 WLLVALCERM-LPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVI-STISLSWF 678
+L L + Y ++ + L DY LY+ +++ + S + WF
Sbjct: 1029 EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWF 1088
Query: 679 LTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYL 738
LTLF S V D F +G +VIF++AL++L + ++ C+ + L L
Sbjct: 1089 LTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTL 1148
Query: 739 DSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIF----RLIRTSY--------EKFGTIRA 786
+ + +S + Y EV+ L +SY EK +
Sbjct: 1149 PDMNTSEMEKIITQVFEMDISKQLHAY-EVEYHVLQDELQESSYSCEDSETLEKLERANS 1207
Query: 787 DLIEQ-MRFKQRLKV----IQTLE---------DTTKRNVVRTIVTETSFTIDELEELYA 832
L Q M ++L+V IQ LE +T ++++RT+ E +E+L
Sbjct: 1208 QLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRK 1267
Query: 833 LFKAEHLTSC 842
L A+ L +C
Sbjct: 1268 LLPADALVNC 1277
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 98.2 bits (243), Expect = 4e-20
Identities = 62/224 (27%), Positives = 112/224 (50%), Gaps = 7/224 (3%)
Query: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
TEK + KGIP +RGE+W LL K Y L ++ G + +I+ D+
Sbjct: 90 TEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDV 148
Query: 565 HRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWL 622
+R+ +H F++ G+ +L VL AY+ N +GYCQ M+ +T++LL+Y EE+AFW
Sbjct: 149 NRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWA 208
Query: 623 LVALC---ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTI-SLSWF 678
LV L + + ++ L Q E++ ++ +L + + ++ ++ WF
Sbjct: 209 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 268
Query: 679 LTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 722
FL PF + + D + +EG +V+ ++ +L + L+
Sbjct: 269 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLM 312
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 98.2 bits (243), Expect = 4e-20
Identities = 62/224 (27%), Positives = 112/224 (50%), Gaps = 7/224 (3%)
Query: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
TEK + KGIP +RGE+W LL K Y L ++ G + +I+ D+
Sbjct: 107 TEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDV 165
Query: 565 HRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWL 622
+R+ +H F++ G+ +L VL AY+ N +GYCQ M+ +T++LL+Y EE+AFW
Sbjct: 166 NRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWA 225
Query: 623 LVALC---ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTI-SLSWF 678
LV L + + ++ L Q E++ ++ +L + + ++ ++ WF
Sbjct: 226 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 285
Query: 679 LTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 722
FL PF + + D + +EG +V+ ++ +L + L+
Sbjct: 286 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLM 329
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/255 (27%), Positives = 126/255 (49%), Gaps = 27/255 (10%)
Query: 515 GIPESMRGELWLLLSG------AINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRS- 567
GIP+ R ++WL L+ AI+ T + E+S + +I +DLHR+
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFN---ERSNPDDDSMGIQIVKDLHRTG 142
Query: 568 LPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLL--LYAKEEEAFWLLVA 625
+ + E L+RVL AYA N +GYCQ NI+ +++L + E +A +++
Sbjct: 143 CSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIY 202
Query: 626 LCERMLPDYYNTRVVGAL-VDQGVFEELARDYVPQLYDCMQDLG--------------VI 670
L +++LP+ Y + AL VD VF +L R +P+L + L +
Sbjct: 203 LIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLT 262
Query: 671 STISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA 730
+ ++ WFLTLF + +P ++ + + D F+EG ++I +++LA+ +++ C+ E
Sbjct: 263 NVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEF 322
Query: 731 MTVLGRYLDSVTNKD 745
+ +GR + D
Sbjct: 323 YSTMGRLTQEMLEND 337
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/255 (27%), Positives = 126/255 (49%), Gaps = 27/255 (10%)
Query: 515 GIPESMRGELWLLLSG------AINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRS- 567
GIP+ R ++WL L+ AI+ T + E+S + +I +DLHR+
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFN---ERSNPDDDSMGIQIVKDLHRTG 142
Query: 568 LPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLL--LYAKEEEAFWLLVA 625
+ + E L+RVL AYA N +GYCQ NI+ +++L + E +A +++
Sbjct: 143 CSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIY 202
Query: 626 LCERMLPDYYNTRVVGAL-VDQGVFEELARDYVPQLYDCMQDLG--------------VI 670
L +++LP+ Y + AL VD VF +L R +P+L + L +
Sbjct: 203 LIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLT 262
Query: 671 STISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA 730
+ ++ WFLTLF + +P ++ + + D F+EG ++I +++LA+ +++ C+ E
Sbjct: 263 NVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEF 322
Query: 731 MTVLGRYLDSVTNKD 745
+ +GR + D
Sbjct: 323 YSTMGRLTQEMLEND 337
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 94.0 bits (232), Expect = 8e-19
Identities = 69/255 (27%), Positives = 126/255 (49%), Gaps = 27/255 (10%)
Query: 515 GIPESMRGELWLLLSG------AINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRS- 567
GIP+ R ++WL L+ AI+ T + E+S + +I +DLHR+
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFN---ERSNPDDDSMGIQIVKDLHRTG 142
Query: 568 LPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLL--LYAKEEEAFWLLVA 625
+ + E L+RVL AYA N +GYCQ NI+ +++L + E +A +++
Sbjct: 143 CSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIY 202
Query: 626 LCERMLPDYYNTRVVGAL-VDQGVFEELARDYVPQLYDCMQDLG--------------VI 670
L +++LP+ Y + AL VD VF +L R +P+L + L +
Sbjct: 203 LIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLT 262
Query: 671 STISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEA 730
+ ++ WFLTLF + +P ++ + + D F+EG ++I +++LA+ +++ C+ E
Sbjct: 263 NVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEF 322
Query: 731 MTVLGRYLDSVTNKD 745
+ +GR + D
Sbjct: 323 YSTMGRLTQEMLEND 337
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 79.7 bits (195), Expect = 2e-14
Identities = 71/287 (24%), Positives = 124/287 (43%), Gaps = 16/287 (5%)
Query: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
K+ +E + W E+ + K + V KGIP ++RG +W +L K
Sbjct: 66 KIRREMTRTSKWMEMLGEWET---YKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLK 122
Query: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAA--LRRVLTAYAFRNP 595
+PG Y+ + E+ + + I+ D+ +L H F++ G L +L AY+ NP
Sbjct: 123 NPGRYQIMKERGK-RSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNP 181
Query: 596 NIGYCQAMNIVTSVLLLYAKEEEAFWLLVALC---ERMLPDYY--NTRVVGALVDQGVFE 650
+GYC+ ++ +T++ LLY EE+AFW LV L LP ++ N V L DQ E
Sbjct: 182 EVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQ--E 239
Query: 651 ELARDYVPQLYDCMQDLGVI-STISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQL 709
+ P+ G+ SL L + + + + D + EG +V+ +
Sbjct: 240 HVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPI 299
Query: 710 ALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHS 756
L +L+ G + ++ D+ D T+ + HL +
Sbjct: 300 TSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTV--LKHLRA 344
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 76.6 bits (187), Expect = 1e-13
Identities = 42/124 (33%), Positives = 69/124 (55%), Gaps = 3/124 (2%)
Query: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
+ K + KG+P ++RG +W +L K +PG Y+ + EK K + + I+RD+
Sbjct: 91 SRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGK-KSSEHIQRIDRDV 149
Query: 565 HRSLPEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWL 622
+L +H F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW
Sbjct: 150 SGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 623 LVAL 626
LV L
Sbjct: 210 LVQL 213
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 75.9 bits (185), Expect = 2e-13
Identities = 41/124 (33%), Positives = 69/124 (55%), Gaps = 3/124 (2%)
Query: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
+ K + KG+P ++RG +W +L K +PG Y+ + EK + + + I+RD+
Sbjct: 91 SRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDI 149
Query: 565 HRSLPEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWL 622
+L +H F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 623 LVAL 626
LV L
Sbjct: 210 LVQL 213
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 75.9 bits (185), Expect = 2e-13
Identities = 41/124 (33%), Positives = 69/124 (55%), Gaps = 3/124 (2%)
Query: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
+ K + KG+P ++RG +W +L K +PG Y+ + EK + + + I+RD+
Sbjct: 91 SRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDI 149
Query: 565 HRSLPEHPAFQNEMGIAA--LRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWL 622
+L +H F++ G L +L AY NP +GYC+ ++ + ++ LLY EE+AFW
Sbjct: 150 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209
Query: 623 LVAL 626
LV L
Sbjct: 210 LVQL 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,624,242
Number of Sequences: 37866
Number of extensions: 2197642
Number of successful extensions: 9993
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 120
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 9185
Number of HSP's gapped (non-prelim): 702
length of query: 1266
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1152
effective length of database: 13,930,794
effective search space: 16048274688
effective search space used: 16048274688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.