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Search of human proteins with 7657152
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657152 hect domain and RLD 3 [Homo sapiens]
(1050 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657152 hect domain and RLD 3 [Homo sapiens] 2138 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 1176 0.0
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 1176 0.0
gi|61563742 hect domain and RLD 6 [Homo sapiens] 659 0.0
gi|110825982 hect domain and RLD 5 [Homo sapiens] 621 e-177
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 311 3e-84
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 279 1e-74
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 279 1e-74
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 279 1e-74
gi|222352183 neural precursor cell expressed, developmentally do... 184 3e-46
gi|21361472 neural precursor cell expressed, developmentally dow... 184 3e-46
gi|222352094 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352092 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352090 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352088 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352086 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352084 neural precursor cell expressed, developmentally do... 184 3e-46
gi|222352082 neural precursor cell expressed, developmentally do... 184 3e-46
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 184 5e-46
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 183 6e-46
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 181 2e-45
gi|126032348 hect domain and RLD 2 [Homo sapiens] 178 2e-44
gi|114520609 neural precursor cell expressed, developmentally do... 178 2e-44
gi|114520607 neural precursor cell expressed, developmentally do... 178 2e-44
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 172 1e-42
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 172 1e-42
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 170 6e-42
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 170 6e-42
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 170 7e-42
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 167 4e-41
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 2138 bits (5539), Expect = 0.0
Identities = 1050/1050 (100%), Positives = 1050/1050 (100%)
Query: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
Sbjct: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180
TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180
Query: 181 PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR
Sbjct: 181 PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Query: 241 TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA 300
TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA
Sbjct: 241 TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA 300
Query: 301 CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK 360
CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK
Sbjct: 301 CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK 360
Query: 361 YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 420
YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA
Sbjct: 361 YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 420
Query: 421 NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE 480
NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE
Sbjct: 421 NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE 480
Query: 481 QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP 540
QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP
Sbjct: 481 QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP 540
Query: 541 SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKV 600
SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKV
Sbjct: 541 SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKV 600
Query: 601 NLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQ 660
NLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQ
Sbjct: 601 NLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQ 660
Query: 661 AKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELS 720
AKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELS
Sbjct: 661 AKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELS 720
Query: 721 IHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDT 780
IHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDT
Sbjct: 721 IHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDT 780
Query: 781 CFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE 840
CFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE
Sbjct: 781 CFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE 840
Query: 841 LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI 900
LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI
Sbjct: 841 LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI 900
Query: 901 SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP 960
SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP
Sbjct: 901 SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP 960
Query: 961 TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYN 1020
TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYN
Sbjct: 961 TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYN 1020
Query: 1021 LLDLPKYSSKEILSARLTQALDNYEGFSLA 1050
LLDLPKYSSKEILSARLTQALDNYEGFSLA
Sbjct: 1021 LLDLPKYSSKEILSARLTQALDNYEGFSLA 1050
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 1176 bits (3041), Expect = 0.0
Identities = 592/1054 (56%), Positives = 758/1054 (71%), Gaps = 11/1054 (1%)
Query: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
MLCWG S GQ G+ + IV EP+ F ++ V++V CG H+VF+L+DG VYTCG
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
N GQLGHE+ KPEQ+ AL Q+I+ V+CGE+H+LAL+D+GQ+++WG SDGQLGL+
Sbjct: 61 NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180
+E+ + VPR I+ L+ I+QV+CG +H LAL+ + F WG+N +GQLGLG + Q S
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 181 PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
PQ ++SL GIP QVAAGGAHSF L+LSGA+FGWG N GQLGL+DE DR P +K LR
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
Query: 241 TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA 300
+QK+VYI CGE+HTA LTK GGVFTFGAG GQLGH+S + E+NPR+V ELMGS VT+IA
Sbjct: 241 SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300
Query: 301 CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK 360
CGRQHT AFVPSSG IY+FG G GQLGTG T N K P VKG W ++GQ D +
Sbjct: 301 CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360
Query: 361 YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 420
Y VK+IFSGGDQ+F S +N P DFR N +N+ I W S
Sbjct: 361 YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420
Query: 421 NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE 480
N + SS+ C NGSFL D+H++T + G+D+N+ R+LF KL+ H I +
Sbjct: 421 EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480
Query: 481 QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP 540
Q+ S E LIP+L+SS PDVEA+R YL LPE PL+ DS + T+ IP A++ L+ P
Sbjct: 481 QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540
Query: 541 SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPV---LFNNYITAALKLLEKL 597
KVL+NWWS + P F+K+V L+K V++LL+ K + P +FN+++ ALK+LE L
Sbjct: 541 LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600
Query: 598 YKVNLKV-KHVEYDTFYIPEISNLVDIQEDYLMWFLHQA-GMKARPSIIQDTVTLCSYPF 655
++VN K+ + ++YD FYI E+ L+DI+ DY+ W QA GM A VT+C+YPF
Sbjct: 601 HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMLA-----DIPVTICTYPF 655
Query: 656 IFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDA 715
+FDAQAKT +LQTDA LQMQ+A++ A+ QNV L L + + +P L+L VRR N+VGDA
Sbjct: 656 VFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLF-LPVIESVNPCLILVVRRENIVGDA 714
Query: 716 LRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLL 775
+ L +ID KKPLKVIF GE+AVDAGGV KEFFLL+++ELL+P YGMF YY+DS L+
Sbjct: 715 MEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLI 774
Query: 776 WFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEG 835
WFSD F + + FHLIG+ CGLAIYN T+VDLHFPLALYKKLL KP L+DLKEL P G
Sbjct: 775 WFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVG 834
Query: 836 RSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVN 895
RS+Q+LLDYP +D+EETFCLNFTI E++G E K+L+ G + V K NRQEFVDAYV+
Sbjct: 835 RSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVD 894
Query: 896 YVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDY 955
Y+F SV + AF +GF KVCGGKVL LFQP+EL+AM++GN+NY+W+ELE+ YKG+Y
Sbjct: 895 YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEY 954
Query: 956 SATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVA 1015
A HPT+K+FWE FHE PLEKKK+FLLFLTGSDRIPI GM SL++VIQST GEEYLPV+
Sbjct: 955 WAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYLPVS 1014
Query: 1016 HTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
HTC+NLLDLPKY+ KE L ++L QA+D+ EGFSL
Sbjct: 1015 HTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 1176 bits (3041), Expect = 0.0
Identities = 591/1057 (55%), Positives = 759/1057 (71%), Gaps = 9/1057 (0%)
Query: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
MLCWG S GQ G+ + IV EP+ F ++ V++V CG H+VF+L+DG VYTCG
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
N GQLGHE+ KPEQ+ AL Q+I+ V+CGE+H+LAL+D+GQ+++WG SDGQLGL+
Sbjct: 61 NDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180
+E+ + VPR I+ L+ I+QV+CG +H LAL+ + F WG+N +GQLGLG + Q S
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 181 PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
PQ ++SL GIP QVAAGGAHSF L+LSGA+FGWG N GQLGL+DE DR P +K LR
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLR 240
Query: 241 TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA 300
+QK+VYI CGE+HTA LTK GGVFTFGAG GQLGH+S + E+NPR+V ELMGS VT+IA
Sbjct: 241 SQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIA 300
Query: 301 CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK 360
CGRQHT AFVPSSG IY+FG G GQLGTG T N K P VKG W ++GQ D +
Sbjct: 301 CGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE 360
Query: 361 YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 420
Y VK+IFSGGDQ+F S +N P DFR N +N+ I W S
Sbjct: 361 YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPV 420
Query: 421 NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE 480
N + SS+ C NGSFL D+H++T + G+D+N+ R+LF KL+ H I +
Sbjct: 421 EIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKLIQPDHPQISQ 480
Query: 481 QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP 540
Q+ S E LIP+L+SS PDVEA+R YL LPE PL+ DS + T+ IP A++ L+ P
Sbjct: 481 QVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP 540
Query: 541 SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPV---LFNNYITAALKLLEKL 597
KVL+NWWS + P F+K+V L+K V++LL+ K + P +FN+++ ALK+LE L
Sbjct: 541 LKVLENWWSVLEPPLFLKIVELFKEVVVHLLKLYKIGIPPSERRIFNSFLHTALKVLEIL 600
Query: 598 YKVNLKV-KHVEYDTFYIPEISNLVDIQEDYLMWFLHQA-GMKARPSIIQ---DTVTLCS 652
++VN K+ + ++YD FYI E+ L+DI+ DY+ W QA GM + + VT+C+
Sbjct: 601 HRVNEKMGQIIQYDKFYIHEVQELIDIRNDYINWVQQQAYGMDVNHGLTELADIPVTICT 660
Query: 653 YPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLV 712
YPF+FDAQAKT +LQTDA LQMQ+A++ A+ QNV L L + + +P L+L VRR N+V
Sbjct: 661 YPFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLF-LPVIESVNPCLILVVRRENIV 719
Query: 713 GDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS 772
GDA+ L +ID KKPLKVIF GE+AVDAGGV KEFFLL+++ELL+P YGMF YY+DS
Sbjct: 720 GDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS 779
Query: 773 NLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 832
L+WFSD F + + FHLIG+ CGLAIYN T+VDLHFPLALYKKLL KP L+DLKEL P
Sbjct: 780 RLIWFSDKTFEDSDLFHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMP 839
Query: 833 TEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDA 892
GRS+Q+LLDYP +D+EETFCLNFTI E++G E K+L+ G + V K NRQEFVDA
Sbjct: 840 DVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDA 899
Query: 893 YVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYK 952
YV+Y+F SV + AF +GF KVCGGKVL LFQP+EL+AM++GN+NY+W+ELE+ YK
Sbjct: 900 YVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYK 959
Query: 953 GDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYL 1012
G+Y A HPT+K+FWE FHE PLEKKK+FLLFLTGSDRIPI GM SL++VIQST GEEYL
Sbjct: 960 GEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTGGGEEYL 1019
Query: 1013 PVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
PV+HTC+NLLDLPKY+ KE L ++L QA+D+ EGFSL
Sbjct: 1020 PVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 659 bits (1700), Expect = 0.0
Identities = 394/1017 (38%), Positives = 578/1017 (56%), Gaps = 36/1017 (3%)
Query: 38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGHE--REGNKPEQIGALADQHIIHVACGESH 95
+ A G HS+ LL + V +CG N++GQLG + G PE I AL + V+CG+ H
Sbjct: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEH 86
Query: 96 SLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 155
SLA+ +G++F+WGAGS+GQLG+ ++ P+ I LN I+QVSCG++H LAL+ D
Sbjct: 87 SLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKD 146
Query: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215
Q F+WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSL G FGWG
Sbjct: 147 SQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWG 206
Query: 216 MNNAGQLGLSDEK---DRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
N+AGQL LS P V L+ VVYISCG+ HTAVLT+ G VFTFG G
Sbjct: 207 SNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSG 266
Query: 273 QLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
QLG+ ++ P +++E + V+QI CG HTLA+V ++G + +FG G
Sbjct: 267 QLGYSPTPEKRGP-QLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG---------P 316
Query: 333 CNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRT 392
+ P+ + A+ F VK IF+G FV + + + A
Sbjct: 317 SDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTL 376
Query: 393 MNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTS 452
+ + + ++ IAV +++ +EH A + + I SS AC SFL+K+ +
Sbjct: 377 PEISRISQSMAEKWIAV-KRRSTEHEMAK--SEIRMIFSSPACLTASFLKKRGTGETTSI 433
Query: 453 PKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPE 512
+DL R F+KL ++ I I E L+ L P EA+ ++L+LPE
Sbjct: 434 ----DVDLEMARDTFKKL--TKKEWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPE 487
Query: 513 FPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVL-YLL 571
P++ DSK + L +P A A+ + +VL W+ + L+ + K A++ LL
Sbjct: 488 CPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLL 547
Query: 572 RGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWF 631
KT + + A L ++++L+KVN + +TF I E+SNL++ D
Sbjct: 548 HQTKT----EQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQL 603
Query: 632 LHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLT 691
+ P+ V +PFIF++ +K K+LQ D+ ++MQ++ A + +L
Sbjct: 604 FRDNHL--IPAETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQ 661
Query: 692 LEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFF 751
+ SP +L VRR+ LV DALR+LS D K L V F E ++GGV+ EFF
Sbjct: 662 KKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFF 721
Query: 752 LLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPL 811
+ +E+ P YGMF Y + + +WF E + L G+ CGL+++N V +L FPL
Sbjct: 722 HCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPL 781
Query: 812 ALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKK 871
ALYKKLL+ KP LEDLKELSP G+SLQE+LD +D+ + C+ F+I + V
Sbjct: 782 ALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDV----D 837
Query: 872 LIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELR 931
LIP G ++ V + N++++V Y++Y+F +SV Y F GF +VC ++L F P EL
Sbjct: 838 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELM 897
Query: 932 AMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIP 991
++GN++Y+W++ E+ + Y+ Y +HPT++LFW+ FH+ L++KKKFL FLTG DR+
Sbjct: 898 TAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 957
Query: 992 IYGMASLQIVIQSTAS-GEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
G+ ++IV + + E P + TC+N+L LPKYS+ E + L A++N GF
Sbjct: 958 ARGIQKMEIVFRCPETFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1014
Score = 110 bits (276), Expect = 5e-24
Identities = 74/221 (33%), Positives = 114/221 (51%), Gaps = 9/221 (4%)
Query: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
+ WG S GQ GI + I P+ ++D + +V+CG HS+ L +D +V++ G
Sbjct: 96 VFAWGAGSEGQLGIG-EFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGK 154
Query: 61 NTKGQLGHERE---GNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
N+ GQLG +E P+++ +L + VA G +HS ALS G F WG+ S GQL
Sbjct: 155 NSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLA 214
Query: 118 LMTTEDSVA--VPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEF 175
L V P + L ++ +SCG+ H L DG+ FT+G N GQLG
Sbjct: 215 LSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPT- 273
Query: 176 PSQASPQRVRSLEGIPLAQVAAGGAHSFA-LSLSGAVFGWG 215
P + PQ V ++G+ ++Q+ G H+ A + +G V +G
Sbjct: 274 PEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 92.0 bits (227), Expect = 3e-18
Identities = 56/174 (32%), Positives = 86/174 (49%), Gaps = 13/174 (7%)
Query: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMN 217
+F WG +S + +R G L Q A+G HS L + V G N
Sbjct: 2 YFCWGADSR-----------ELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDN 50
Query: 218 NAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHD 277
+ GQLG + E P ++ L T V +SCG+EH+ + G VF +GAGS GQLG
Sbjct: 51 SRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIG 110
Query: 278 SMND-EVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
+ P++++ L ++ Q++CG H+LA S ++++G + GQLG G
Sbjct: 111 EFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDS-QVFSWGKNSHGQLGLG 163
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 3/111 (2%)
Query: 4 WGYWSLGQPGIS-TNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNT 62
WG S GQ +S N+ +P G + + V ++CG H+ L +DG+V+T G N
Sbjct: 205 WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264
Query: 63 KGQLGHEREGNK-PEQIGALADQHIIHVACGESHSLA-LSDRGQLFSWGAG 111
GQLG+ K Q+ D + + CG H+LA + GQ+ S+G G
Sbjct: 265 SGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 621 bits (1601), Expect = e-177
Identities = 354/958 (36%), Positives = 550/958 (57%), Gaps = 41/958 (4%)
Query: 92 GESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLA 151
G H L LS G+ F + S L R L ++ I+Q++CG++H LA
Sbjct: 105 GAEHMLILSSDGKPFEYDNYSMKHL------------RFESILQEKKIIQITCGDYHSLA 152
Query: 152 LAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAV 211
L+ G+ F WG+N HGQLG+G++FPS +PQ V L G+PLAQ++AG AHS ALS+SG +
Sbjct: 153 LSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNI 212
Query: 212 FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSC 271
+ WG N GQLGL + ++ P ++ L QKV +++CG H+A+LT+ G +FTFGAG
Sbjct: 213 YSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
Query: 272 GQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGH 331
GQLGH+S +E+ P V EL+G VTQIACGR HTLA+V G +++FG G GQLG G
Sbjct: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
Query: 332 TCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFR 391
T + P PVK + S +L + + ++ + +GG+Q+ +L K EN
Sbjct: 333 TRDQLMPLPVK---VSSSEELKLESHTSEKELI--MIAGGNQSILLWIKKEN-------S 380
Query: 392 TMNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKT 451
+N +N+ T+ W + +T + +I SS AC GSFL K+ +T
Sbjct: 381 YVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPACLTGSFLRKR-----RT 435
Query: 452 SPKIP-GIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLIL 510
+ +P +DLN R +F++L +Q I I + L+ +L P EA+ I+ +L
Sbjct: 436 TEMMPVYLDLNKARNIFKEL--TQKDWITNMITTCLKDNLLKRLPFHSPPQEALEIFFLL 493
Query: 511 PEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYL 570
PE P++ S + +L +P A + ++ S VL+ +W+ + F KLV ++K AV+
Sbjct: 494 PECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKLVQMFKTAVICQ 553
Query: 571 LRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW 630
L + N + A L++L+KL++VN + F + E+ + ++ +
Sbjct: 554 L---DYWDESAEENGNVQALLEMLKKLHRVNQVKCQLPESIFQVDELLHRLNFFVEVCRR 610
Query: 631 FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLL 690
+L + + A + +Q V +PFIF+ +K K+L TD L+++ + A L++ +
Sbjct: 611 YLWKMTVDASEN-VQCCVIFSHFPFIFNNLSKIKLLHTDTLLKIESKKHKAYLRSAAIEE 669
Query: 691 TLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEF 750
E A P L VRRN+L+ D L +LS + DL+K L V F GE D GGV KEF
Sbjct: 670 ERESEFALRPTFDLTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSGEIGYDLGGVKKEF 729
Query: 751 FLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFP 810
F L E++ P YGMF Y + ++ +WF E + G+ CGL+++N V +L FP
Sbjct: 730 FYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKFEKKRYFFFGVLCGLSLFNCNVANLPFP 789
Query: 811 LALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQK 870
LAL+KKLL+ P LEDLKELSP G++LQ LLD G++ EE F ++F + +
Sbjct: 790 LALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNVHWDR----NDT 845
Query: 871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSEL 930
LIP G ++TV + N++++V Y+NY+F SV Y F GF K+C +++LF P EL
Sbjct: 846 NLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEEL 905
Query: 931 RAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRI 990
+ ++VGN++Y+W+ E+ A Y+ Y+++HPT+ +FW+ FH+ LE+KKKFL+FLTG+DR+
Sbjct: 906 KDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRL 965
Query: 991 PIYGMASLQIVIQSTASGEEYLPV-AHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
+ + +++I S E P+ A TC+++L LPKYS+ E + L +A++N GF
Sbjct: 966 QMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1023
Score = 150 bits (379), Expect = 6e-36
Identities = 88/251 (35%), Positives = 130/251 (51%), Gaps = 11/251 (4%)
Query: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESH 95
+ V G H + L DG+ + + L E L ++ II + CG+ H
Sbjct: 99 IHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFE---------SILQEKKIIQITCGDYH 149
Query: 96 SLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD 155
SLALS G+LF+WG GQLG+ S P++++ L + Q+S G H +AL+
Sbjct: 150 SLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209
Query: 156 GQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWG 215
G ++WGKN GQLGLG S+ P + L+ + VA GG+HS L+ G +F +G
Sbjct: 210 GNIYSWGKNECGQLGLG-HTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFG 268
Query: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHT-AVLTKSGGVFTFGAGSCGQL 274
GQLG + ++ PC V L +V I+CG HT A ++ G VF+FG+G GQL
Sbjct: 269 AGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQL 328
Query: 275 GHDSMNDEVNP 285
G+ D++ P
Sbjct: 329 GNGGTRDQLMP 339
Score = 128 bits (321), Expect = 3e-29
Identities = 81/235 (34%), Positives = 122/235 (51%), Gaps = 6/235 (2%)
Query: 31 ISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHERE---GNKPEQIGALADQHII 87
+ ++ + ++ CG HS+ L + GE++ G N GQLG R+ P+ + LA +
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 88 HVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNW 147
++ GE+HS+ALS G ++SWG GQLGL TE S P LI+ L+ Q + V+CG
Sbjct: 195 QISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE-SKDDPSLIEGLDNQKVEFVACGGS 253
Query: 148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA-LS 206
H L DG FT+G HGQLG ++ P V L G + Q+A G H+ A +S
Sbjct: 254 HSALLTQDGLLFTFGAGKHGQLG-HNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVS 312
Query: 207 LSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSG 261
G VF +G GQLG +D+ P VK+ ++++ S E ++ G
Sbjct: 313 DLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGG 367
Score = 106 bits (265), Expect = 1e-22
Identities = 62/175 (35%), Positives = 93/175 (53%), Gaps = 5/175 (2%)
Query: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
+ WG GQ G+ PQ+ ++ + +++ G HS+ L G +Y+ G
Sbjct: 159 LFAWGQNLHGQLGVGRKFPSTTT-PQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
Query: 61 NTKGQ--LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
N GQ LGH + P I L +Q + VACG SHS L+ G LF++GAG GQLG
Sbjct: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGH 277
Query: 119 MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAAD-GQFFTWGKNSHGQLGLG 172
+T++ + P L+ +L + Q++CG WH LA +D G+ F++G GQLG G
Sbjct: 278 NSTQNELR-PCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
Score = 85.5 bits (210), Expect = 2e-16
Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 6/178 (3%)
Query: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
WG GQ G+ +P + + ++ V+ VACGG+HS L +DG ++T G
Sbjct: 215 WGKNECGQLGLGHTESK--DDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKH 272
Query: 64 GQLGHEREGN--KPEQIGALADQHIIHVACGESHSLA-LSDRGQLFSWGAGSDGQLGLMT 120
GQLGH N +P + L + +ACG H+LA +SD G++FS+G+G DGQLG
Sbjct: 273 GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGG 332
Query: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFPS 177
T D + + +++ L+ + +A Q W K + + L + P+
Sbjct: 333 TRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWIKKENSYVNLKRTIPT 390
Score = 44.3 bits (103), Expect = 6e-04
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 12/99 (12%)
Query: 232 SPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLEL 291
+P +KL + K+ + G EH +L+ G F + S L +S+ L
Sbjct: 87 TPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESI-----------L 135
Query: 292 MGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
++ QI CG H+LA + G ++A+G GQLG G
Sbjct: 136 QEKKIIQITCGDYHSLA-LSKGGELFAWGQNLHGQLGVG 173
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 311 bits (796), Expect = 3e-84
Identities = 209/614 (34%), Positives = 318/614 (51%), Gaps = 43/614 (7%)
Query: 457 GIDLNSTRVLFEKLMNSQHSM---ILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEF 513
GI+ +++ L+N+ + +L+ I+NS + + P + +R Y IL +
Sbjct: 184 GINAKFVNAVYDTLLNTPQDVQKTVLKGIINS-----LLREWKGPRTKDDLRAYFILLQN 238
Query: 514 PLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVN-LYKGAVLYLLR 572
P ++ Y+ + L I L L +W+ ++ K F +LV L + L L
Sbjct: 239 PQFNNTSTYV-IYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFP 297
Query: 573 GRKTFLIPVLFNNY-ITAALKLLEKLYKVNLKVKH--VEYDTFYIPEISNLVDIQEDYLM 629
+ P+ ++ I +A K+L L N V + Y FY + + +D+ E+Y
Sbjct: 298 AKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDH-IDLMEEYHT 356
Query: 630 WFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFML 689
W G R S C YPF+ AK ++Q D+E QM +N A V +
Sbjct: 357 W--QNFGNSHRFSF-------CQYPFVISVAAKKIIIQRDSEQQM---INIARQSLVDKV 404
Query: 690 LTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKE 749
+ FL + VRR +LV D+L EL+ DLKK LKV F GE +D GG+TKE
Sbjct: 405 SRRQRPDMNILFLNMKVRRTHLVSDSLDELT-RKRADLKKKLKVTFVGEAGLDMGGLTKE 463
Query: 750 FFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHF 809
+FLLL++++ +P YGMFTY++DS+ WFS ++ F L+GI GLA+YNS +D+ F
Sbjct: 464 WFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRF 523
Query: 810 PLALYKKLL---------NVKPGL-----EDLKELSPTEGRSLQELLDYPGEDVEETFCL 855
P YKKLL N+ G+ +DL ++ P L ELL + G +VEE F
Sbjct: 524 PPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEG-NVEEDFYS 582
Query: 856 NFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLK 915
F + +E +G+I+ L PGGD ++V NR+E+V Y +++ S+++ + AF GF
Sbjct: 583 TFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHS 642
Query: 916 VCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLE 975
VC L L +P E+ ++ G+ + + L+ + Y G Y+ T T+K FW+ FPL+
Sbjct: 643 VCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDG-YAKTDLTIKYFWDVVLGFPLD 701
Query: 976 KKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSA 1035
+KK L F TGSDR+P+ GMA L I + LPVAHTC+N L LP Y SK+ L
Sbjct: 702 LQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
Query: 1036 RLTQALDNYEGFSL 1049
+L + N EGF L
Sbjct: 762 KLIIGISNSEGFGL 775
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 279 bits (713), Expect = 1e-74
Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)
Query: 607 VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666
+ ++ F ++ ++++ +DY + + ++ + + PFI +A K L
Sbjct: 441 IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 490
Query: 667 QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723
D ++M + + + +L +L +P+L L VRR++++ DAL L ++ +
Sbjct: 491 YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 544
Query: 724 DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783
DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP GMFTY + + L WF+ + F
Sbjct: 545 PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 604
Query: 784 EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843
F LIGI GLAIYN+ ++D+HFP+ +Y+KL+ K DL + P +SL++LL+
Sbjct: 605 TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 664
Query: 844 YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902
Y G +VE+ + F I + + +G L GD + + +NR+EFV+ Y +Y+ SV
Sbjct: 665 YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 723
Query: 903 HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961
+ + AF GF V L+ LF+P E+ ++ G+ N +++ LEET Y G Y+
Sbjct: 724 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 783
Query: 962 VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021
++ FWE H F E+K+ FL F TG+DR P+ G+ L+++I E LP +HTC+N+
Sbjct: 784 IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 843
Query: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049
L LP+YSSKE L RL +A+ +GF +
Sbjct: 844 LLLPEYSSKEKLKERLLKAITYAKGFGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 279 bits (713), Expect = 1e-74
Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)
Query: 607 VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666
+ ++ F ++ ++++ +DY + + ++ + + PFI +A K L
Sbjct: 421 IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 470
Query: 667 QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723
D ++M + + + +L +L +P+L L VRR++++ DAL L ++ +
Sbjct: 471 YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 524
Query: 724 DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783
DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP GMFTY + + L WF+ + F
Sbjct: 525 PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 584
Query: 784 EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843
F LIGI GLAIYN+ ++D+HFP+ +Y+KL+ K DL + P +SL++LL+
Sbjct: 585 TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 644
Query: 844 YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902
Y G +VE+ + F I + + +G L GD + + +NR+EFV+ Y +Y+ SV
Sbjct: 645 YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 703
Query: 903 HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961
+ + AF GF V L+ LF+P E+ ++ G+ N +++ LEET Y G Y+
Sbjct: 704 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 763
Query: 962 VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021
++ FWE H F E+K+ FL F TG+DR P+ G+ L+++I E LP +HTC+N+
Sbjct: 764 IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 823
Query: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049
L LP+YSSKE L RL +A+ +GF +
Sbjct: 824 LLLPEYSSKEKLKERLLKAITYAKGFGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 279 bits (713), Expect = 1e-74
Identities = 157/448 (35%), Positives = 257/448 (57%), Gaps = 22/448 (4%)
Query: 607 VEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKML 666
+ ++ F ++ ++++ +DY + + ++ + + PFI +A K L
Sbjct: 444 IPFEEFINEPLNEVLEMDKDYTFFKVET----------ENKFSFMTCPFILNAVTKNLGL 493
Query: 667 QTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALREL---SIHS 723
D ++M + + + +L +L +P+L L VRR++++ DAL L ++ +
Sbjct: 494 YYDNRIRMY------SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMEN 547
Query: 724 DIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV 783
DLKK L V F+GE+ VD GGV+KEFF L+++E+ NP GMFTY + + L WF+ + F
Sbjct: 548 PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFE 607
Query: 784 EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLD 843
F LIGI GLAIYN+ ++D+HFP+ +Y+KL+ K DL + P +SL++LL+
Sbjct: 608 TEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLE 667
Query: 844 YPGEDVEETFCLNFTICR-ESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISV 902
Y G +VE+ + F I + + +G L GD + + +NR+EFV+ Y +Y+ SV
Sbjct: 668 YEG-NVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSV 726
Query: 903 HEWYTAFSSGFLKVCGGKVLE-LFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPT 961
+ + AF GF V L+ LF+P E+ ++ G+ N +++ LEET Y G Y+
Sbjct: 727 EKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVL 786
Query: 962 VKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNL 1021
++ FWE H F E+K+ FL F TG+DR P+ G+ L+++I E LP +HTC+N+
Sbjct: 787 IREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNV 846
Query: 1022 LDLPKYSSKEILSARLTQALDNYEGFSL 1049
L LP+YSSKE L RL +A+ +GF +
Sbjct: 847 LLLPEYSSKEKLKERLLKAITYAKGFGM 874
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 619 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 675 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 735 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 795 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 600 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 659
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 660 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 719
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 720 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 775
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 776 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 835
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 836 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 895
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 896 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 599 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 654
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 655 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 714
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 715 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 774
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 775 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 479 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 538
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 539 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 598
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 599 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 654
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 655 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 714
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 715 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 774
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 775 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 592 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 651
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 652 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 711
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 712 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 767
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 768 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 827
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 828 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 887
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 888 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 612 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 671
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 672 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 731
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 732 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 787
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 788 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 847
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 848 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 907
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 908 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 620 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 679
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 680 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 739
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 740 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 795
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 796 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 855
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 856 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 915
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 916 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 619 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 675 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 735 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 795 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 184 bits (468), Expect = 3e-46
Identities = 109/356 (30%), Positives = 185/356 (51%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALREL-SIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ + RNN+ ++ R + S+ LK L + F+ E+ +D GGV +E+F LL KE+ NP
Sbjct: 499 MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPY 558
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG GLA+++ ++D F YK +
Sbjct: 559 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMM 618
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L + L D++ + SL+ +L+ +++ FC++ E++G Q L P G
Sbjct: 619 LGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCID----EENFGQTYQVDLKPNGS 674
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V +N++E++D + + F V + AF GF ++ ++++F +EL +M G
Sbjct: 675 EIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGL 734
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + + +IYK Y HP ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 735 GDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAE 794
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q+ E LP AHTC+N LDLP Y + E L +L A++N +GF
Sbjct: 795 LYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 184 bits (466), Expect = 5e-46
Identities = 116/363 (31%), Positives = 189/363 (52%), Gaps = 15/363 (4%)
Query: 696 LARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLL 755
LA + + V R L D+ +++ S DL++ L VIF GEE +D GGV +E+F LL
Sbjct: 501 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS 560
Query: 756 KELLNPIYGMFTYY-QDSNLLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPL 811
E+LNP+Y +F Y +D+ L + ++ +H +F IG +A+++ +D F L
Sbjct: 561 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL 620
Query: 812 ALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEE-TFCLNFTICRESYGVIEQK 870
YK++LN GL+DL+ + P SL + + ++EE + F++ +E G I+
Sbjct: 621 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKE---NNIEECDLEMYFSVDKEILGEIKSH 677
Query: 871 KLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSEL 930
L P G N+ V ++N++E++ + V E AF GF ++ + L+ F EL
Sbjct: 678 DLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKEL 737
Query: 931 RAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRI 990
++ G + + + AIY+ Y+ T + FW+ E EK+ + L F+TG+ R+
Sbjct: 738 EVLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRL 796
Query: 991 PIYGMASL------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNY 1044
P+ G A L Q E +LP +HTC+N LDLP Y S E L +L A++
Sbjct: 797 PVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEET 856
Query: 1045 EGF 1047
EGF
Sbjct: 857 EGF 859
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 183 bits (465), Expect = 6e-46
Identities = 119/381 (31%), Positives = 193/381 (50%), Gaps = 16/381 (4%)
Query: 681 ANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKK-PLKVIFDGEE 739
A L+N + L + L L +RR++L+ DA ++ +S DL++ L V F GEE
Sbjct: 1195 AKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEE 1254
Query: 740 AVDAGGVTKEFFLLLLKELLNPIYGMFTYY-QDSNLLWFSD-TCFVE--HNWFHLIGITC 795
+D G ++EFF L+ +EL NP YG+F Y D+ + S + FV+ H WF G
Sbjct: 1255 GLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRIL 1314
Query: 796 GLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCL 855
GLA+ + ++D F YK LL + L DL+ L +SLQ + D D+ + L
Sbjct: 1315 GLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKD---NDIHDILDL 1371
Query: 856 NFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLK 915
FT+ E +G I +++L PGG N+ V + N++E+++ V + + V + + GF +
Sbjct: 1372 TFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYE 1431
Query: 916 VCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLE 975
V +++ +F EL ++ G + + + Y+G Y H ++ FW F E
Sbjct: 1432 VVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNE 1491
Query: 976 KKKKFLLFLTGSDRIPIYGMASL-------QIVIQSTASGEEYLPVAHTCYNLLDLPKYS 1028
++ + L F+TG+ IP G ASL + ++ LP AHTC+N LDLP Y
Sbjct: 1492 QRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGK-ITALPRAHTCFNRLDLPPYP 1550
Query: 1029 SKEILSARLTQALDNYEGFSL 1049
S +L +L A++ F L
Sbjct: 1551 SFSMLYEKLLTAVEETSTFGL 1571
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 181 bits (460), Expect = 2e-45
Identities = 119/357 (33%), Positives = 188/357 (52%), Gaps = 17/357 (4%)
Query: 7 WSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQL 66
W G+ G V P S ++V CG N + + +G V CG + G+L
Sbjct: 4002 WGAGRHGQLAEAGRNVMVPAAAPSFSQ--AQQVICGQNCTFVIQANGTVLACGEGSYGRL 4059
Query: 67 GHEREGNKPEQ-----IGALADQHIIHV--ACG-ESHSLALSDRGQLFSWGAGSDGQLGL 118
G +GN + I AL + + +CG + HS+AL++ G++FSWG G G+LG
Sbjct: 4060 G---QGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLG- 4115
Query: 119 MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQ 178
D PR I+ L + ++Q+SCG H + +DG+ FT+G +G+LGLG ++
Sbjct: 4116 HGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNT-SNK 4174
Query: 179 ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA-VFGWGMNNAGQLGLSDEKDRESPCHVK 237
P+RV +LEG + QVA G H+ A+S G+ V+ +G + G+LGL + + SP +
Sbjct: 4175 KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKID 4234
Query: 238 LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVT 297
+L + ++CG + + LTK G V+TFG L + P+++ L G +
Sbjct: 4235 VLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4294
Query: 298 QIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSA 354
+A G +HTLA S+G +YA+G + GQLG GHT +V+ P+ V G + Q+SA
Sbjct: 4295 DVAVGAEHTLALA-SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISA 4350
Score = 157 bits (396), Expect = 6e-38
Identities = 111/331 (33%), Positives = 169/331 (51%), Gaps = 9/331 (2%)
Query: 6 YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGN-HSVFLLEDGEVYTCGLNTKG 64
Y LGQ G S +L + + GF+ + V +CG + HS+ L E GEV++ G G
Sbjct: 4056 YGRLGQ-GNSDDLHVLTVISALQGFVVTQLV--TSCGSDGHSMALTESGEVFSWGDGDYG 4112
Query: 65 QLGHEREGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122
+LGH +P QI AL + ++ ++CG HS ++ G+LF++G G G+LGL T
Sbjct: 4113 KLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTS 4172
Query: 123 DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF-FTWGKNSHGQLGLGKEFPSQASP 181
+ +P + L I QV+CG H LA++ADG + +G +G+LGLG +++SP
Sbjct: 4173 NK-KLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNS-TAKSSP 4230
Query: 182 QRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRT 241
Q++ L GI + +VA G S AL+ G V+ +G + L ++ P + +L
Sbjct: 4231 QKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAG 4290
Query: 242 QKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIAC 301
+ ++ G EHT L +G V+ +G+ S GQLG N P V L G V QI+
Sbjct: 4291 VIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISA 4350
Query: 302 GRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
GR H+ A+ A G QLG T
Sbjct: 4351 GRCHSAAWTAPPVPPRAPGVSVPLQLGLPDT 4381
Score = 139 bits (351), Expect = 1e-32
Identities = 85/262 (32%), Positives = 132/262 (50%), Gaps = 8/262 (3%)
Query: 83 DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142
D+ I+ A L + ++ WGAG GQL +V VP +Q QV
Sbjct: 3977 DEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLA--EAGRNVMVPAAAPSFSQAQ--QV 4032
Query: 143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG---G 199
CG + A+G G+ S+G+LG G + +L+G + Q+
Sbjct: 4033 ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTV-ISALQGFVVTQLVTSCGSD 4091
Query: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTK 259
HS AL+ SG VF WG + G+LG + + P ++ L+ ++VV +SCG +H+AV+T
Sbjct: 4092 GHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTS 4151
Query: 260 SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAF 319
G +FTFG G G+LG + +++ P RV L G ++ Q+ACG HTLA +++AF
Sbjct: 4152 DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAF 4211
Query: 320 GCGARGQLGTGHTCNVKCPSPV 341
G G G+LG G++ P +
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKI 4233
Score = 131 bits (330), Expect = 3e-30
Identities = 92/314 (29%), Positives = 163/314 (51%), Gaps = 20/314 (6%)
Query: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACG---GNHSVFLLEDGEVYTCGL 60
+G LG + L+ + EP RS+K+V+ H++ +GEV++ G
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPH-------RSIKKVSSSKGSDGHTLAFTTEGEVFSWGD 484
Query: 61 NTKGQLGHEREGNK--PEQI-GALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
G+LGH + P+ I G L + ++ V+ G HS A+++ G+L++WG G G+LG
Sbjct: 485 GDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
Query: 118 LMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ-FFTWGKNSHGQLGLGKEFP 176
+S +P L++ ++ + +VSCG+ H +AL+ DG+ +++G +G+LG G +
Sbjct: 545 -HGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG-DTN 600
Query: 177 SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHV 236
P+ + +L+G+ + +V AG S AL+ +G V+ WG G S E P +
Sbjct: 601 RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLI 659
Query: 237 KLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVN-PRRVLELMGSE 295
+ L ++V +S G+ H L+ V+ +G S GQ G + + P++V L G
Sbjct: 660 EELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIA 719
Query: 296 VTQIACGRQHTLAF 309
+ QI+ G H+LA+
Sbjct: 720 IQQISAGTSHSLAW 733
Score = 130 bits (327), Expect = 6e-30
Identities = 98/311 (31%), Positives = 158/311 (50%), Gaps = 23/311 (7%)
Query: 26 QVCGFISDRSVKEVACGGNHSV------FLLEDGEVYTCGLNTKGQL--GHEREGNKPEQ 77
+VC SD S C S+ + E EVY G N+ QL G + + +P+
Sbjct: 342 EVCRMASDYSR---TCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKL 398
Query: 78 IGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQ 137
+ +D I G+ + +S G + + G GS G+LGL + + + +L + ++
Sbjct: 399 APSFSDAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHR- 455
Query: 138 TILQVSCG---NWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS-LEGIPLA 193
+I +VS + H LA +G+ F+WG +G+LG G +Q P+ ++ L+G +
Sbjct: 456 SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNS-STQKYPKLIQGPLQGKVVV 514
Query: 194 QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEH 253
V+AG HS A++ G ++ WG + G+LG D R P VK + V +SCG H
Sbjct: 515 CVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSH 572
Query: 254 TAVLTKSGG-VFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPS 312
T L+K G V++FG G G+LGH N P+ + L G + ++ G Q +LA + S
Sbjct: 573 TIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLA-LTS 631
Query: 313 SGLIYAFGCGA 323
+G +YA+GCGA
Sbjct: 632 TGQVYAWGCGA 642
Score = 128 bits (321), Expect = 3e-29
Identities = 101/360 (28%), Positives = 168/360 (46%), Gaps = 20/360 (5%)
Query: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLE-DGEVYTCGLNT 62
WG S Q + Q + +P++ SD E G + F++ DG V CG +
Sbjct: 377 WGSNSSHQ--LVEGTQEKILQPKLAPSFSDAQTIEA---GQYCTFVISTDGSVRACGKGS 431
Query: 63 KGQLGHEREGNKPEQIGALADQH-----IIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
G+LG N+ + H + + H+LA + G++FSWG G G+LG
Sbjct: 432 YGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLG 491
Query: 118 LMTTEDSVAVPRLIQ-KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFP 176
+ P+LIQ L + ++ VS G H A+ DG+ +TWG+ G+LG G +
Sbjct: 492 -HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG-DSN 549
Query: 177 SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSG-AVFGWGMNNAGQLGLSDEKDRESPCH 235
S+ P V+ + + +V+ G +H+ ALS G V+ +G + G+LG D P
Sbjct: 550 SRNIPTLVKDISNV--GEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKV 607
Query: 236 VKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSE 295
++ L+ + + G + + LT +G V+ +G G+C G S + P+ + EL +
Sbjct: 608 IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCG-SSEATALRPKLIEELAATR 666
Query: 296 VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGH-TCNVKCPSPVKGYWAAHSGQLSA 354
+ ++ G H LA + +YA+G + GQ G G+ T + P V G Q+SA
Sbjct: 667 IVDVSIGDSHCLA-LSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725
Score = 113 bits (282), Expect = 1e-24
Identities = 71/250 (28%), Positives = 134/250 (53%), Gaps = 14/250 (5%)
Query: 99 LSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 158
+S+ +++ WG+ S QL + T++ + P+L + ++ G + ++ DG
Sbjct: 368 VSETCEVYVWGSNSSHQL-VEGTQEKILQPKLAPSFSDAQTIEA--GQYCTFVISTDGSV 424
Query: 159 FTWGKNSHGQLGLGKEFPSQASPQRV-----RSLEGIPLAQVAAGGAHSFALSLSGAVFG 213
GK S+G+LGLG + +Q++ +++ RS++ + ++ + G H+ A + G VF
Sbjct: 425 RACGKGSYGRLGLG-DSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFS 481
Query: 214 WGMNNAGQLGLSDEKDRESPCHVK-LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
WG + G+LG + ++ P ++ L+ + VV +S G H+A +T+ G ++T+G G G
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFG 541
Query: 273 QLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
+LGH N P V ++ S V +++CG HT+A +++FG G G+LG G T
Sbjct: 542 RLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDT 599
Query: 333 CNVKCPSPVK 342
V P ++
Sbjct: 600 NRVYKPKVIE 609
Score = 107 bits (267), Expect = 6e-23
Identities = 92/337 (27%), Positives = 150/337 (44%), Gaps = 23/337 (6%)
Query: 726 DLKKPL---KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMF---------TYYQDSN 773
DL+ P KV GE A DAGGV + + +EL I + Y
Sbjct: 4504 DLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDR 4563
Query: 774 LLWFSDTCFVEHNW-FHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSP 832
L+ C EH F +GI G+AI +DLH ++K+L V LEDL+E+
Sbjct: 4564 FLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDL 4623
Query: 833 TEGRSLQELLDYPG-----EDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQ 887
++L +L E E L+ + + + G + +IPGG+++ + NR+
Sbjct: 4624 LYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADG--KMVPIIPGGNSIPLTFSNRK 4681
Query: 888 EFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEE 947
E+V+ + Y + A G + +L L +L M+ G + E L++
Sbjct: 4682 EYVERAIEYRLH-EMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKK 4740
Query: 948 TAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI-YGMASLQIVIQSTA 1006
Y+ + H V+ FW T EF E++ F+ F++G R+P S + I
Sbjct: 4741 VVRYR-EVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVD 4799
Query: 1007 SGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDN 1043
+ LP + TC+ L LP YSS+ +++ RL A++N
Sbjct: 4800 RPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINN 4836
Score = 105 bits (263), Expect = 2e-22
Identities = 80/260 (30%), Positives = 121/260 (46%), Gaps = 12/260 (4%)
Query: 4 WG---YWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
WG Y LG ST + + G + + V V+ G HS + EDGE+YT G
Sbjct: 482 WGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
Query: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQ-LFSWGAGSDGQLGLM 119
G+LGH ++ ++ V+CG SH++ALS G+ ++S+G G +G+LG
Sbjct: 538 GDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHG 597
Query: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179
T + V P++I+ L I +V G+ LAL + GQ + WG + LG G +
Sbjct: 598 DT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGAC--LGCGSSEATAL 654
Query: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDR-ESPCHVKL 238
P+ + L + V+ G +H ALS V+ WG N+ GQ G + P V
Sbjct: 655 RPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSG 714
Query: 239 LRTQKVVYISCGEEHTAVLT 258
L + IS G H+ T
Sbjct: 715 LDGIAIQQISAGTSHSLAWT 734
Score = 69.7 bits (169), Expect = 1e-11
Identities = 45/144 (31%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
Query: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNT-KGQLGHEREGNKPEQIGA 80
V +P+V + +++V G S+ L G+VY G G E +P+ I
Sbjct: 602 VYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEE 661
Query: 81 LADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTIL 140
LA I+ V+ G+SH LALS ++++WG S GQ G + + P+ + L+ I
Sbjct: 662 LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQ 721
Query: 141 QVSCGNWHCL---ALAADGQFFTW 161
Q+S G H L AL D Q W
Sbjct: 722 QISAGTSHSLAWTALPRDRQVVAW 745
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 178 bits (452), Expect = 2e-44
Identities = 125/346 (36%), Positives = 181/346 (52%), Gaps = 13/346 (3%)
Query: 7 WSLGQPGISTNLQGI-VAEPQVCGFISDRSVKEVACGGNHSVFLLE-DGEVYTCGLNTKG 64
W L L+G + P +S +V +VA GG+ S+F + +G+VY CG T G
Sbjct: 2964 WGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVA-GGSKSLFAVTVEGKVYACGEATNG 3022
Query: 65 QLGHEREGNK---PEQIGALADQHIIHVAC--GESHSLALSDRGQLFSWGAGSDGQLGLM 119
+LG P QI AL+ + VA G H+ AL+ G++FSWG G DG+LG
Sbjct: 3023 RLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHF 3082
Query: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179
+ + PRLI+ L + I ++CG+ H AL + G+ +TWG +G+LG G +Q
Sbjct: 3083 SRMNCDK-PRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDN-TTQL 3140
Query: 180 SPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVK 237
P+ V+ L G + QVA G A + AL+ G VF WG + G+LG + P +++
Sbjct: 3141 KPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIE 3200
Query: 238 LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVT 297
L Q V I CG + + LTKSG V+T+G G +LGH S P+ V L G ++
Sbjct: 3201 RLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIV 3260
Query: 298 QIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
+A G H LA V SG +YA+G GQ G G T + P+ V+G
Sbjct: 3261 HVAVGALHCLA-VTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG 3305
Score = 167 bits (423), Expect = 5e-41
Identities = 105/314 (33%), Positives = 164/314 (52%), Gaps = 10/314 (3%)
Query: 5 GYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVAC--GGNHSVFLLEDGEVYTCGLNT 62
GY + G+ GI V+ P + I +K+VA GG H + L +GEVY+ G
Sbjct: 4010 GYGAGGRLGIGGTES--VSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAE 4067
Query: 63 KGQLGHEREG--NKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
G+LGH ++P I +L ++ VA G +HS ++ G L++WG G G+LG
Sbjct: 4068 DGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD 4127
Query: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQ 178
+ED + P+L++ L ++ ++CG+ L L D ++WG +G+LG G +
Sbjct: 4128 SEDQLK-PKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCK 4186
Query: 179 ASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKL 238
P ++ SL G+ + +V G S AL+ SGAV+ WG + +LG + P V+
Sbjct: 4187 V-PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
Query: 239 LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQ 298
L+ +KV+ I+ G H T+ G V+T+G GQLG + N PR V L G +V +
Sbjct: 4246 LQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNR 4305
Query: 299 IACGRQHTLAFVPS 312
+ACG HTLA+ S
Sbjct: 4306 VACGSAHTLAWSTS 4319
Score = 164 bits (416), Expect = 3e-40
Identities = 105/303 (34%), Positives = 159/303 (52%), Gaps = 11/303 (3%)
Query: 13 GISTNLQGIVAEPQVCGFISDRSVKEVAC--GGNHSVFLLEDGEVYTCGLNTKGQLGHER 70
GIS+ G V P+ +S VK+VA GG H+ L DG+V++ G G+LGH
Sbjct: 3027 GISS---GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFS 3083
Query: 71 EGN--KPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVP 128
N KP I AL + I +ACG SHS AL+ G+L++WG G G+LG + P
Sbjct: 3084 RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK-P 3142
Query: 129 RLIQKLNQQTILQVSCGNWHC--LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRS 186
++++ L ++QV+CG+ LAL +G F+WG G+LG G PQ +
Sbjct: 3143 KMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNI-PQNIER 3201
Query: 187 LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVY 246
L G + Q+ G S AL+ SG V+ WG + +LG + P V+ LR +K+V+
Sbjct: 3202 LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVH 3261
Query: 247 ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHT 306
++ G H +T SG V+ +G GQ G+ + P V L G ++T++ACG H+
Sbjct: 3262 VAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3321
Query: 307 LAF 309
+A+
Sbjct: 3322 VAW 3324
Score = 164 bits (416), Expect = 3e-40
Identities = 106/298 (35%), Positives = 166/298 (55%), Gaps = 11/298 (3%)
Query: 53 GEVYTCGLNTKGQLGHEREGNK---PEQIGALADQHIIHVACGESHSLALSDRGQLFSWG 109
G +Y G N +GQLG EG K P ALA + + GE A++ G+L++ G
Sbjct: 3952 GTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
Query: 110 AGSDGQLGLMTTEDSVAVPRLIQKLNQQTI--LQVSCGNWHCLALAADGQFFTWGKNSHG 167
G+ G+LG+ TE SV+ P L++ + I + V+ G HCLAL+++G+ ++WG+ G
Sbjct: 4011 YGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDG 4069
Query: 168 QLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDE 227
+LG G P P+ + SL GI + VAAGGAHS ++ +G ++ WG G+LG SD
Sbjct: 4070 KLGHGNRSPCDR-PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128
Query: 228 KDRESPCHVKLLRTQKVVYISCG--EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNP 285
+D+ P V+ L+ +VV I+CG + T LT V+++G G G+LG + P
Sbjct: 4129 EDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVP 4188
Query: 286 RRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
++ L G V ++ CG Q ++A + SG +Y +G G +LG G +V+ P V+G
Sbjct: 4189 MKIDSLTGLGVVKVECGSQFSVA-LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG 4245
Score = 156 bits (395), Expect = 8e-38
Identities = 90/259 (34%), Positives = 136/259 (52%), Gaps = 8/259 (3%)
Query: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
WG G+ G + + +P++ + + ++++ACG +HS L GE+YT GL
Sbjct: 3071 WGEGDDGKLGHFSRMN--CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEY 3128
Query: 64 GQLGHEREGN--KPEQIGALADQHIIHVACG--ESHSLALSDRGQLFSWGAGSDGQLGLM 119
G+LGH KP+ + L +I VACG ++ +LAL+D G +FSWG G G+LG
Sbjct: 3129 GRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRG 3188
Query: 120 TTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQA 179
+E +P+ I++LN Q + Q+ CG LAL G +TWGK + +LG G + +
Sbjct: 3189 GSE-GCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVR- 3246
Query: 180 SPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLL 239
PQ V L G + VA G H A++ SG V+ WG N+ GQ G P V+ L
Sbjct: 3247 KPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGL 3306
Query: 240 RTQKVVYISCGEEHTAVLT 258
QK+ ++CG H+ T
Sbjct: 3307 EGQKITRVACGSSHSVAWT 3325
Score = 152 bits (383), Expect = 2e-36
Identities = 108/344 (31%), Positives = 165/344 (47%), Gaps = 17/344 (4%)
Query: 4 WGYWSLGQPGISTNLQGI-VAEPQVCGFISD-RSVKEVACGGNHSVFLLE-DGEVYTCGL 60
WG+ GQ G ++G V P C ++ R V+ + GG ++F + DG++Y G
Sbjct: 3957 WGHNHRGQLG---GIEGAKVKVPTPCEALATLRPVQLI--GGEQTLFAVTADGKLYATGY 4011
Query: 61 NTKGQLGHEREGNKPEQIGALADQHI----IHVACGESHSLALSDRGQLFSWGAGSDGQL 116
G+LG + + QH+ + V G H LALS G+++SWG DG+L
Sbjct: 4012 GAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKL 4071
Query: 117 GLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFP 176
G PR+I+ L ++ V+ G H + A G +TWGK +G+LG +
Sbjct: 4072 G-HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG-HSDSE 4129
Query: 177 SQASPQRVRSLEGIPLAQVAAGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPC 234
Q P+ V +L+G + +A G A + L+ V+ WG + G+LG + P
Sbjct: 4130 DQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPM 4189
Query: 235 HVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGS 294
+ L VV + CG + + LTKSG V+T+G G +LGH S + PR+V L G
Sbjct: 4190 KIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGK 4249
Query: 295 EVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCP 338
+V IA G H + G +Y +G GQLG G T ++ P
Sbjct: 4250 KVIAIATGSLHCVCCT-EDGEVYTWGDNDEGQLGDGTTNAIQRP 4292
Score = 145 bits (367), Expect = 1e-34
Identities = 93/326 (28%), Positives = 160/326 (49%), Gaps = 19/326 (5%)
Query: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL 81
V P C +++ V ++AC + L +G VYT N+ + P+ + L
Sbjct: 439 VIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS--------DTLAPQLVQGL 490
Query: 82 ADQHIIHVACGES--HSLALSDRGQLFSWGAGSDGQLGLMTT---EDSVAVPRLIQKLNQ 136
A ++I+ +A H LAL+ G+++SWG G G+LG T E+ + K
Sbjct: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAG 550
Query: 137 QTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA 196
+ ++ ++CG+ + A+ A+G+ +TWG+ ++G+LG G +A P V L+G+ + VA
Sbjct: 551 KHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSS-EDEAIPMLVAGLKGLKVIDVA 609
Query: 197 AGG--AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHT 254
G A + A++ +G V+ WG + G+LG ++P ++ L+ VV + CG + +
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
Query: 255 AVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSG 314
LTK G V+++G G +LGH + P+ + L G +V +A G H LA S
Sbjct: 670 IALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSE 729
Query: 315 LIYAFGCGARGQLGTGHTCNVKCPSP 340
+ G+ Q T V P P
Sbjct: 730 V---HSWGSNDQCQHFDTLRVTKPEP 752
Score = 141 bits (356), Expect = 3e-33
Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 8/244 (3%)
Query: 98 ALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQ 157
A + R ++F WG QLG + + VP + L+ ++QV+ G+ A+ +G+
Sbjct: 2954 AATIRTKVFVWGLNDKDQLGGLKGS-KIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
Query: 158 FFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVA--AGGAHSFALSLSGAVFGWG 215
+ G+ ++G+LGLG + P+++ +L + +VA +GG H+ AL++ G VF WG
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
Query: 216 MNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLG 275
+ G+LG + + P ++ L+T+++ I+CG H+A LT SG ++T+G G G+LG
Sbjct: 3073 EGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
Query: 276 HDSMNDEVNPRRVLELMGSEVTQIACGRQ--HTLAFVPSSGLIYAFGCGARGQLGTGHT- 332
H ++ P+ V L+G V Q+ACG + TLA + GL++++G G G+LG G +
Sbjct: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLA-LTDEGLVFSWGDGDFGKLGRGGSE 3191
Query: 333 -CNV 335
CN+
Sbjct: 3192 GCNI 3195
Score = 124 bits (312), Expect = 4e-28
Identities = 79/277 (28%), Positives = 140/277 (50%), Gaps = 21/277 (7%)
Query: 75 PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKL 134
P Q LA+ + +AC E L LS G++++ SD P+L+Q L
Sbjct: 442 PIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-----------TLAPQLVQGL 490
Query: 135 NQQTILQVSCGN--WHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIP- 191
+ I++++ + H LALAA G+ ++WG G+LG G P + P+ + + G
Sbjct: 491 ASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLE-EPKVISAFSGKQA 549
Query: 192 ---LAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYIS 248
+ +A G +S A++ G ++ WG N G+LG +D P V L+ KV+ ++
Sbjct: 550 GKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVA 609
Query: 249 CG--EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHT 306
CG + T +T++G V+++G G G+LG + P+ + +L +V ++ CG Q +
Sbjct: 610 CGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFS 669
Query: 307 LAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
+A G +Y++G G +LG G +V+ P ++G
Sbjct: 670 IALT-KDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG 705
Score = 94.7 bits (234), Expect = 4e-19
Identities = 85/326 (26%), Positives = 136/326 (41%), Gaps = 23/326 (7%)
Query: 732 KVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYY----------QDSNLLWFSDTC 781
KV F GE D GG E + +EL N + + +D LL +
Sbjct: 4467 KVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARA 4526
Query: 782 FVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQEL 841
V + F +G+ G+AI + + L+ ++K+L + + DL E+ L +
Sbjct: 4527 PVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYI 4586
Query: 842 LDYPGEDVE-ETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI 900
D E E L FT+ S I+ + + DNR E+V +NY
Sbjct: 4587 RDNEATSEEFEAMSLPFTVPSASGQDIQLSS-----KHTHITLDNRAEYVRLAINYRLH- 4640
Query: 901 SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP 960
E A G +V +L LF EL M+ G+ + L+ A YKG +
Sbjct: 4641 EFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSAS 4699
Query: 961 TVKLFWETFHEFPLEKKKKFLLFLTGSDRIP-----IYGMASLQIVIQSTASGEEYLPVA 1015
++ FWE F ++ FL F+ G R+P G + V+ + +LP +
Sbjct: 4700 LIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPES 4759
Query: 1016 HTCYNLLDLPKYSSKEILSARLTQAL 1041
+TC+ LL LP+YS K++L +L A+
Sbjct: 4760 YTCFFLLKLPRYSCKQVLEEKLKYAI 4785
Score = 82.0 bits (201), Expect = 3e-15
Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 4/181 (2%)
Query: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSG 209
L+ G + WG N GQLG G E P +L + Q+ G FA++ G
Sbjct: 3946 LSAGGSGTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADG 4004
Query: 210 AVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ--KVVYISCGEEHTAVLTKSGGVFTFG 267
++ G G+LG+ + +P ++ ++ K V ++ G +H L+ G V+++G
Sbjct: 4005 KLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWG 4064
Query: 268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQL 327
G+LGH + + PR + L G EV +A G H+ A V ++G +Y +G G G+L
Sbjct: 4065 EAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHS-ACVTAAGDLYTWGKGRYGRL 4123
Query: 328 G 328
G
Sbjct: 4124 G 4124
Score = 57.8 bits (138), Expect = 5e-08
Identities = 43/166 (25%), Positives = 75/166 (45%), Gaps = 13/166 (7%)
Query: 208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFG 267
SG ++GWG N+ GQLG + + P + L T + V + GE+ +T G ++ G
Sbjct: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
Query: 268 AGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA--CGRQHTLAFVPSSGLIYAFGCGARG 325
G+ G+LG P + + + ++A G +H LA + S G +Y++G G
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLA-LSSEGEVYSWGEAEDG 4069
Query: 326 QLGTGHTCNVKCPSPVKGY----------WAAHSGQLSARADRFKY 361
+LG G+ P ++ AHS ++A D + +
Sbjct: 4070 KLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTW 4115
Score = 48.5 bits (114), Expect = 3e-05
Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 16/142 (11%)
Query: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGS 270
V GWG+ +G + P + L V I+C E+ +L+++G V+T S
Sbjct: 425 VIGWGL-----IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS 479
Query: 271 CGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQ-HTLAFVPSSGLIYAFGCGARGQLGT 329
D + P+ V L + +IA H + ++G +Y++GCG G+LG
Sbjct: 480 ----------DTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH 529
Query: 330 GHTCNVKCPSPVKGYWAAHSGQ 351
G T ++ P + + +G+
Sbjct: 530 GDTVPLEEPKVISAFSGKQAGK 551
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/99 (30%), Positives = 48/99 (48%), Gaps = 11/99 (11%)
Query: 22 VAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQ--IG 79
V P++ + + V +VA G H + L ED EV++ G N + Q KPE +
Sbjct: 697 VRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALP 756
Query: 80 ALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
L +HI+ +ACG + S F+W + S+ +GL
Sbjct: 757 GLDTKHIVGIACGPAQS---------FAWSSCSEWSIGL 786
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 178 bits (452), Expect = 2e-44
Identities = 111/356 (31%), Positives = 180/356 (50%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALRELSIHSDID-LKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ +RR ++ D+ R + D LK L + FDGE+ +D GGV +E+F L+ KE+ NP
Sbjct: 545 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 604
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG G+A+Y+ ++D F YK +
Sbjct: 605 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 664
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L+ L D++ + SL+ +L+ +++ L F I E +G Q +L GG
Sbjct: 665 LHKPITLHDMESVDSEYYNSLRWILENDPTELD----LRFIIDEELFGQTHQHELKNGGS 720
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V N++E++ + + F + + AF GF ++ ++++F +EL +M G
Sbjct: 721 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 780
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + E YK YSA H ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 781 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 840
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q E LP AHTC+N LDLP Y S E L +L A++N +GF
Sbjct: 841 LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 178 bits (452), Expect = 2e-44
Identities = 111/356 (31%), Positives = 180/356 (50%), Gaps = 16/356 (4%)
Query: 704 LHVRRNNLVGDALRELSIHSDID-LKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPI 762
+ +RR ++ D+ R + D LK L + FDGE+ +D GGV +E+F L+ KE+ NP
Sbjct: 892 MKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPY 951
Query: 763 YGMFTYYQDSNLLWF----SDTCFVEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817
YG+F Y N S C +H ++F IG G+A+Y+ ++D F YK +
Sbjct: 952 YGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 1011
Query: 818 LNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGD 877
L+ L D++ + SL+ +L+ +++ L F I E +G Q +L GG
Sbjct: 1012 LHKPITLHDMESVDSEYYNSLRWILENDPTELD----LRFIIDEELFGQTHQHELKNGGS 1067
Query: 878 NVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGN 937
+ V N++E++ + + F + + AF GF ++ ++++F +EL +M G
Sbjct: 1068 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL 1127
Query: 938 SNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMAS 997
+ + + E YK YSA H ++ FW+ EK+ + L F+TG+ R+P+ G A
Sbjct: 1128 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE 1187
Query: 998 L------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
L Q E LP AHTC+N LDLP Y S E L +L A++N +GF
Sbjct: 1188 LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 172 bits (436), Expect = 1e-42
Identities = 110/355 (30%), Positives = 183/355 (51%), Gaps = 15/355 (4%)
Query: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763
+ V R L D+ +++ DL++ L +I GEE +D GG+ +E+F LL E+LNP+Y
Sbjct: 78 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 137
Query: 764 GMFTYYQDSN-LLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLN 819
+F Y +N L + + +H +F IG +A+Y+ +D F L YK++LN
Sbjct: 138 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 197
Query: 820 VKPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGVIEQKKLIPGGDN 878
+P L+DL+ + P S+ + + ++EE L F E G + +L GG++
Sbjct: 198 KRPTLKDLESIDPEFYNSIVWIKE---NNLEECGLELYFIQDMEILGKVTTHELKEGGES 254
Query: 879 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNS 938
+ V ++N++E++ ++ F V E AF GF +V + L F EL M+ G
Sbjct: 255 IRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQ 314
Query: 939 NYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASL 998
+ + +++ IY+ Y+ ++ FW+ E EK+ + L F+TG+ R+P+ G A L
Sbjct: 315 EIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAEL 373
Query: 999 ------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
Q E +LP +HTC+N LDLP Y S E L +L A++ EGF
Sbjct: 374 IGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 172 bits (436), Expect = 1e-42
Identities = 110/355 (30%), Positives = 183/355 (51%), Gaps = 15/355 (4%)
Query: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763
+ V R L D+ +++ DL++ L +I GEE +D GG+ +E+F LL E+LNP+Y
Sbjct: 517 ISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMY 576
Query: 764 GMFTYYQDSN-LLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLN 819
+F Y +N L + + +H +F IG +A+Y+ +D F L YK++LN
Sbjct: 577 CLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLN 636
Query: 820 VKPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGVIEQKKLIPGGDN 878
+P L+DL+ + P S+ + + ++EE L F E G + +L GG++
Sbjct: 637 KRPTLKDLESIDPEFYNSIVWIKE---NNLEECGLELYFIQDMEILGKVTTHELKEGGES 693
Query: 879 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNS 938
+ V ++N++E++ ++ F V E AF GF +V + L F EL M+ G
Sbjct: 694 IRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQ 753
Query: 939 NYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASL 998
+ + +++ IY+ Y+ ++ FW+ E EK+ + L F+TG+ R+P+ G A L
Sbjct: 754 EIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAEL 812
Query: 999 ------QIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGF 1047
Q E +LP +HTC+N LDLP Y S E L +L A++ EGF
Sbjct: 813 IGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 170 bits (431), Expect = 6e-42
Identities = 110/360 (30%), Positives = 182/360 (50%), Gaps = 18/360 (5%)
Query: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763
+ V R + ++ R++ DLKK L V F GEE +D GGV +E+ LL E+LNP Y
Sbjct: 401 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 460
Query: 764 GMFTYYQDS-NLLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLN 819
G+F Y D+ +L + + +H ++FH +G GLA+++ ++ F + YK+LL
Sbjct: 461 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 520
Query: 820 VKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNV 879
L DL+ + P +SL +L+ D+ F + ++G I Q +L P G NV
Sbjct: 521 KPIQLSDLESVDPELHKSLVWILE---NDITPVLDHTFCVEHNAFGRILQHELKPNGRNV 577
Query: 880 TVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSN 939
V ++N++E+V YVN+ F + + A GF ++ +L+ F EL ++ G
Sbjct: 578 PVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDK 637
Query: 940 YNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ 999
+ + + K A V+ FW+ F E++ + L F+TGS R+P+ G +LQ
Sbjct: 638 IDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQ 696
Query: 1000 ----------IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
I + + LP AHTC+N +D+P Y S E L +L A++ GF++
Sbjct: 697 GSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 170 bits (431), Expect = 6e-42
Identities = 110/360 (30%), Positives = 182/360 (50%), Gaps = 18/360 (5%)
Query: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763
+ V R + ++ R++ DLKK L V F GEE +D GGV +E+ LL E+LNP Y
Sbjct: 375 IEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYY 434
Query: 764 GMFTYYQDS-NLLWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLN 819
G+F Y D+ +L + + +H ++FH +G GLA+++ ++ F + YK+LL
Sbjct: 435 GLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLG 494
Query: 820 VKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNV 879
L DL+ + P +SL +L+ D+ F + ++G I Q +L P G NV
Sbjct: 495 KPIQLSDLESVDPELHKSLVWILE---NDITPVLDHTFCVEHNAFGRILQHELKPNGRNV 551
Query: 880 TVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSN 939
V ++N++E+V YVN+ F + + A GF ++ +L+ F EL ++ G
Sbjct: 552 PVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDK 611
Query: 940 YNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ 999
+ + + K A V+ FW+ F E++ + L F+TGS R+P+ G +LQ
Sbjct: 612 IDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQ 670
Query: 1000 ----------IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
I + + LP AHTC+N +D+P Y S E L +L A++ GF++
Sbjct: 671 GSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 170 bits (430), Expect = 7e-42
Identities = 113/381 (29%), Positives = 190/381 (49%), Gaps = 16/381 (4%)
Query: 681 ANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKK-PLKVIFDGEE 739
A L+N + L + + L +RR++L+ ++ +S +L++ L V F GEE
Sbjct: 1229 AKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEE 1288
Query: 740 AVDAGGVTKEFFLLLLKELLNPIYGMFTYY-QDSNLLWFSD-TCFVEHN--WFHLIGITC 795
+D G ++EFF LL +EL NP YG+F Y D+ + S + FVE++ WF G
Sbjct: 1289 GLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRIL 1348
Query: 796 GLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCL 855
GLA+ + ++D F YK LL + L DL+ L +SLQ + D ++ + L
Sbjct: 1349 GLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDL 1405
Query: 856 NFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLK 915
FT+ E +G + +++L GG N V + N++E+++ V + + V + A GF +
Sbjct: 1406 TFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYE 1465
Query: 916 VCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLE 975
V +++ +F EL ++ G + + + Y+G Y H ++ FW F E
Sbjct: 1466 VVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNE 1525
Query: 976 KKKKFLLFLTGSDRIPIYGMASL-------QIVIQSTASGEEYLPVAHTCYNLLDLPKYS 1028
++ + L F+TG+ +P G A+L + I+ LP AHTC+N LDLP Y
Sbjct: 1526 QRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYP 1584
Query: 1029 SKEILSARLTQALDNYEGFSL 1049
S +L +L A++ F L
Sbjct: 1585 SYSMLYEKLLTAVEETSTFGL 1605
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 167 bits (424), Expect = 4e-41
Identities = 112/358 (31%), Positives = 181/358 (50%), Gaps = 17/358 (4%)
Query: 704 LHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIY 763
+ V R + ++ R++ DL K L + F GEE +D GGV +E+ LL E+LNP Y
Sbjct: 395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454
Query: 764 GMFTYYQDS--NLLWFSDTCF-VEH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLN 819
G+F Y +D L D+ EH ++FH +G G+A+++ +D F L YK+LL
Sbjct: 455 GLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLG 514
Query: 820 VKPGLEDLKELSPTEGRSLQELLDYPGEDV-EETFCLNFTICRESYGVIEQKKLIPGGDN 878
L+D++ + P SL +L+ V + TFC+ +YG I Q +L P G +
Sbjct: 515 KSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVE----HNAYGEIIQHELKPNGKS 570
Query: 879 VTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNS 938
+ V ++N++E+V YVN+ F + + A GF +V +L+ F EL ++ G
Sbjct: 571 IPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLG 630
Query: 939 NYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASL 998
+ + + K + VK FW+ F E++ + L F+TGS R+P+ G +L
Sbjct: 631 KIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKAL 689
Query: 999 Q-------IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
Q I + LP AHTC+N +D+P Y S E L +L A++ GF++
Sbjct: 690 QGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 747
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,825,396
Number of Sequences: 37866
Number of extensions: 1793301
Number of successful extensions: 4538
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3332
Number of HSP's gapped (non-prelim): 250
length of query: 1050
length of database: 18,247,518
effective HSP length: 113
effective length of query: 937
effective length of database: 13,968,660
effective search space: 13088634420
effective search space used: 13088634420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.