Search of human proteins with 7656928

Search of human proteins with 7656928

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
         (424 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...   856   0.0  
gi|7705308 growth differentiation factor 2 [Homo sapiens]             300   1e-81
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   177   2e-44
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   153   3e-37
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   153   3e-37
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   153   3e-37
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   142   4e-34
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   140   2e-33
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      139   6e-33
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   132   8e-31
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   129   5e-30
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             126   3e-29
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   124   2e-28
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   124   2e-28
gi|222352098 nodal precursor [Homo sapiens]                            97   2e-20
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]      97   4e-20
gi|110349792 growth differentiation factor 1 [Homo sapiens]            96   5e-20
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    95   1e-19
gi|4504699 inhibin beta A precursor [Homo sapiens]                     93   5e-19
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    91   3e-18
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...    89   1e-17
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    88   1e-17
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...    88   2e-17
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...    84   2e-16
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]           82   1e-15
gi|13899338 activin beta E [Homo sapiens]                              82   1e-15
gi|4885259 myostatin [Homo sapiens]                                    81   2e-15
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       77   2e-14
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    75   9e-14
gi|63025222 transforming growth factor, beta 1 [Homo sapiens]          70   5e-12

>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score =  856 bits (2212), Expect = 0.0
 Identities = 424/424 (100%), Positives = 424/424 (100%)

Query: 1   MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD 60
           MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD
Sbjct: 1   MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD 60

Query: 61  EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF 120
           EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF
Sbjct: 61  EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF 120

Query: 121 NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE 180
           NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE
Sbjct: 121 NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE 180

Query: 181 RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE 240
           RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE
Sbjct: 181 RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE 240

Query: 241 IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL 300
           IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL
Sbjct: 241 IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL 300

Query: 301 QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL 360
           QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL
Sbjct: 301 QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL 360

Query: 361 AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE 420
           AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE
Sbjct: 361 AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE 420

Query: 421 CGCR 424
           CGCR
Sbjct: 421 CGCR 424


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score =  300 bits (769), Expect = 1e-81
 Identities = 168/378 (44%), Positives = 243/378 (64%), Gaps = 15/378 (3%)

Query: 55  LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLF 114
           L+++K +FL++LNLS +P+QD  +V+PP+YM++LYN++ +D+++ P++NI+RSF  ED  
Sbjct: 59  LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAI 118

Query: 115 SQPVSFN-GLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLES 173
           S   + +   +K+ LLFN+SIP HE++  AELRLY   Q        +   + I++VL+ 
Sbjct: 119 SITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDG 178

Query: 174 KGD-NEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS--STHQLEVHIESKHDE 230
               +        LVS +I   +  WET +V+ A++RW +S S  S ++LEV +ES H +
Sbjct: 179 TDAWDSATETKTFLVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVES-HRK 235

Query: 231 AEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD-KERKEELNEMISHEQLPELDNLGLDS 289
             D     L+I     +++ P  +VFS+D SS  KE + EL EMISHEQ   L  L  D 
Sbjct: 236 GCDT----LDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDG 291

Query: 290 FSSGPGEEALLQMRSNIIYDST-ARIRRNA-KGNYCKRTPLYIDFKEIGWDSWIIAPPGY 347
            +             ++   ST AR +R+A  G++C++T L ++F++IGWDSWIIAP  Y
Sbjct: 292 STEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEY 351

Query: 348 EAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL-DKGV 406
           EAYEC+G C +PLA+ +TPTKHAI+Q LVHLK   K  KACCVPTKL PIS+LY  D GV
Sbjct: 352 EAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGV 411

Query: 407 VTYKFKYEGMAVSECGCR 424
            T K+ YEGM+V+ECGCR
Sbjct: 412 PTLKYHYEGMSVAECGCR 429


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  177 bits (449), Expect = 2e-44
 Identities = 123/389 (31%), Positives = 179/389 (46%), Gaps = 59/389 (15%)

Query: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTS----------MPSAN 103
           +L   +   L    L   PT     V PP YML+LY + +    S             AN
Sbjct: 49  VLSEFELRLLSMFGLKQRPTPSRDAVVPP-YMLDLYRRHSGQPGSPAPDHRLERAASRAN 107

Query: 104 IIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIYDG-V 161
            +RSF +E+   +    +G       FN+S IP  E +  AEL+++    +D +  +   
Sbjct: 108 TVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSF 167

Query: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLE 221
             +I I+E+++    N       +L +  +    S WE+FDVT A+ RW   G + H   
Sbjct: 168 HHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFV 227

Query: 222 VHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDKERKEELNEMIS 275
           V + +  +E +  S   + I  S  Q++H+     PLL+ F  D       K E  +   
Sbjct: 228 VEV-AHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQA-K 285

Query: 276 HEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEI 335
           H+Q                                    R+  K + CKR PLY+DF ++
Sbjct: 286 HKQ------------------------------------RKRLKSS-CKRHPLYVDFSDV 308

Query: 336 GWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLE 395
           GW+ WI+APPGY A+ C G C +PLA+HL  T HAI+Q LV+  NS K  KACCVPT+L 
Sbjct: 309 GWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNS-KIPKACCVPTELS 367

Query: 396 PISILYLDKGVVTYKFKYEGMAVSECGCR 424
            IS+LYLD+        Y+ M V  CGCR
Sbjct: 368 AISMLYLDENEKVVLKNYQDMVVEGCGCR 396


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  153 bits (386), Expect = 3e-37
 Identities = 116/395 (29%), Positives = 171/395 (43%), Gaps = 63/395 (15%)

Query: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELY------------NKFATDRTSMPS 101
           LL+  +   L+   L   P Q S     P+YM +LY            +    +    P+
Sbjct: 53  LLRDFEATLLQMFGLRRRP-QPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111

Query: 102 --ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIY 158
             AN +RSF +E+        +    +  LFN+S IP +E +  AELRL+         +
Sbjct: 112 SRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDW 171

Query: 159 DGVDRKITIFEVLESKGDN-EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSST 217
           +    +I I+EV++   +   G     +L +  ++   + WETFDV+ A+ RW +     
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPN 231

Query: 218 HQLEVHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDK--ERKEE 269
           + L + +   H +        + I  S  Q   N     PLL+ F  D        R+  
Sbjct: 232 YGLAIEVTHLH-QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRA 290

Query: 270 LNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLY 329
                 H Q                                    R   K   C+R  LY
Sbjct: 291 KRSPKHHSQ------------------------------------RARKKNKNCRRHSLY 314

Query: 330 IDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACC 389
           +DF ++GW+ WI+APPGY+A+ C G C +PLA+HL  T HAI+Q LV+  NS    KACC
Sbjct: 315 VDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNS-SIPKACC 373

Query: 390 VPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424
           VPT+L  IS+LYLD+        Y+ M V  CGCR
Sbjct: 374 VPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  153 bits (386), Expect = 3e-37
 Identities = 116/395 (29%), Positives = 171/395 (43%), Gaps = 63/395 (15%)

Query: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELY------------NKFATDRTSMPS 101
           LL+  +   L+   L   P Q S     P+YM +LY            +    +    P+
Sbjct: 53  LLRDFEATLLQMFGLRRRP-QPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111

Query: 102 --ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIY 158
             AN +RSF +E+        +    +  LFN+S IP +E +  AELRL+         +
Sbjct: 112 SRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDW 171

Query: 159 DGVDRKITIFEVLESKGDN-EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSST 217
           +    +I I+EV++   +   G     +L +  ++   + WETFDV+ A+ RW +     
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPN 231

Query: 218 HQLEVHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDK--ERKEE 269
           + L + +   H +        + I  S  Q   N     PLL+ F  D        R+  
Sbjct: 232 YGLAIEVTHLH-QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRA 290

Query: 270 LNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLY 329
                 H Q                                    R   K   C+R  LY
Sbjct: 291 KRSPKHHSQ------------------------------------RARKKNKNCRRHSLY 314

Query: 330 IDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACC 389
           +DF ++GW+ WI+APPGY+A+ C G C +PLA+HL  T HAI+Q LV+  NS    KACC
Sbjct: 315 VDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNS-SIPKACC 373

Query: 390 VPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424
           VPT+L  IS+LYLD+        Y+ M V  CGCR
Sbjct: 374 VPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  153 bits (386), Expect = 3e-37
 Identities = 116/395 (29%), Positives = 171/395 (43%), Gaps = 63/395 (15%)

Query: 54  LLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELY------------NKFATDRTSMPS 101
           LL+  +   L+   L   P Q S     P+YM +LY            +    +    P+
Sbjct: 53  LLRDFEATLLQMFGLRRRP-QPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPA 111

Query: 102 --ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIY 158
             AN +RSF +E+        +    +  LFN+S IP +E +  AELRL+         +
Sbjct: 112 SRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDW 171

Query: 159 DGVDRKITIFEVLESKGDN-EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSST 217
           +    +I I+EV++   +   G     +L +  ++   + WETFDV+ A+ RW +     
Sbjct: 172 ERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPN 231

Query: 218 HQLEVHIESKHDEAEDASSGRLEIDTSA-QNKHN-----PLLIVFSDDQSSDK--ERKEE 269
           + L + +   H +        + I  S  Q   N     PLL+ F  D        R+  
Sbjct: 232 YGLAIEVTHLH-QTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRA 290

Query: 270 LNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLY 329
                 H Q                                    R   K   C+R  LY
Sbjct: 291 KRSPKHHSQ------------------------------------RARKKNKNCRRHSLY 314

Query: 330 IDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACC 389
           +DF ++GW+ WI+APPGY+A+ C G C +PLA+HL  T HAI+Q LV+  NS    KACC
Sbjct: 315 VDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNS-SIPKACC 373

Query: 390 VPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424
           VPT+L  IS+LYLD+        Y+ M V  CGCR
Sbjct: 374 VPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  142 bits (359), Expect = 4e-34
 Identities = 125/391 (31%), Positives = 168/391 (42%), Gaps = 58/391 (14%)

Query: 72  PTQDSAKVDPPEYMLELYNKF---------ATDRTSMPSANIIRSFKNEDLFSQPVSFNG 122
           P     +V P EYML +Y  +         A+   S  SAN I SF +  L    +S   
Sbjct: 85  PPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGL--DDLSHTP 142

Query: 123 LRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGER 181
           LR+   LF+VS +   EE++ AELRL+                + +F  L          
Sbjct: 143 LRRQKYLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSP-------- 194

Query: 182 NMLVLVSGEIYGTNSE---WETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGR 238
             L+L +  +    +    WE FDV   +R                E    EAE  + G 
Sbjct: 195 --LLLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGP 252

Query: 239 LEIDTSAQN-----------KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGL 287
            +                  +   LL+VF+  Q     RK    EM   EQL   +  G 
Sbjct: 253 QQPPPPDLRSLGFGRRVRPPQERALLVVFTRSQ-----RKNLFAEM--REQLGSAEAAGP 305

Query: 288 DSFSSG------------PGEEALLQMRSNIIYDSTARIRRNAKGNY-CKRTPLYIDFKE 334
            + + G            P   +  + R    + S    R   K    C + PL+++FKE
Sbjct: 306 GAGAEGSWPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKE 365

Query: 335 IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKL 394
           +GWD WIIAP  YEAY C GVC++PL  HL PT HAIIQ L++  +      +CCVPTKL
Sbjct: 366 LGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKL 425

Query: 395 EPISILYLDKG-VVTYKFKYEGMAVSECGCR 424
            PISILY+D G  V YK +YE M V  CGCR
Sbjct: 426 TPISILYIDAGNNVVYK-QYEDMVVESCGCR 455


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  140 bits (353), Expect = 2e-33
 Identities = 91/340 (26%), Positives = 154/340 (45%), Gaps = 44/340 (12%)

Query: 95  DRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFN---VSIPHHEEVIMAELRLYTLV 151
           D   +  A+++ SF N  L  +   F+  R++   F      IPH E V  AE R+Y   
Sbjct: 147 DTNFLNDADMVMSFVN--LVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYK-- 202

Query: 152 QRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQ 211
            R    ++    KI+I+++++   + + +  + +L + +    +  W  FD+T     W 
Sbjct: 203 DRSNNRFENETIKISIYQIIKEYTNRDAD--LFLLDTRKAQALDVGWLVFDITVTSNHWV 260

Query: 212 KSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVF--------SDDQSSD 263
            +  +   L++  E+    + +  S  L      Q+K  P ++ F           ++++
Sbjct: 261 INPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ-PFMVAFFKASEVLLRSVRAAN 319

Query: 264 KERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYC 323
           K + +  N+  SH+    + ++G   +++   ++A                        C
Sbjct: 320 KRKNQNRNKSSSHQDSSRMSSVG--DYNTSEQKQA------------------------C 353

Query: 324 KRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQK 383
           K+  LY+ F+++GW  WIIAP GY A+ C G C++PL  H+  T HAI+Q LVHL     
Sbjct: 354 KKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDH 413

Query: 384 ASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
             K CC PTKL  IS+LY D        KY  M V  CGC
Sbjct: 414 VPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  139 bits (349), Expect = 6e-33
 Identities = 105/401 (26%), Positives = 168/401 (41%), Gaps = 55/401 (13%)

Query: 56  QSMKDEFLKTLNLSDIPTQ--DSAKVDPPEYMLELYNKFATDRTSMPS------------ 101
           + M+ E L  L L   P           P +ML+LYN  A +    P             
Sbjct: 52  REMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVF 111

Query: 102 ------------------ANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIM 142
                             A+++ SF N     +             F++S IP  E V  
Sbjct: 112 STQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTA 171

Query: 143 AELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFD 202
           AE R+Y    R+R  +D    +I++++VL+     E +  + +L S  ++ +   W  FD
Sbjct: 172 AEFRIYKDYIRER--FDNETFRISVYQVLQEHLGRESD--LFLLDSRTLWASEEGWLVFD 227

Query: 203 VTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSS 262
           +T     W  +      L++ +E+   ++ +     L      QNK   ++  F   +  
Sbjct: 228 ITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVH 287

Query: 263 DKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNY 322
            +  +   ++  S  +            S  P  +  L+M +N+  +S++  R+      
Sbjct: 288 FRSIRSTGSKQRSQNR------------SKTPKNQEALRM-ANVAENSSSDQRQA----- 329

Query: 323 CKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQ 382
           CK+  LY+ F+++GW  WIIAP GY AY C G C +PL  ++  T HAI+Q LVH  N +
Sbjct: 330 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPE 389

Query: 383 KASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
              K CC PT+L  IS+LY D        KY  M V  CGC
Sbjct: 390 TVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  132 bits (331), Expect = 8e-31
 Identities = 116/367 (31%), Positives = 167/367 (45%), Gaps = 53/367 (14%)

Query: 79  VDPPEYMLELYNKFA-TDRTSMPS--------ANIIRSFKNEDLFSQ-PVSFNGLRKYPL 128
           + P EYML LY   +  DR    S        AN I SF ++    + PV    +RK   
Sbjct: 167 ITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPV----VRKQRY 222

Query: 129 LFNVSIPHHEEVIMAELRLYTLVQRD--RMIYDGVDRKITIFEVLESKGDNEGERNMLVL 186
           +F++S    + ++ AELR+      D  +    G  R       L+      G +   +L
Sbjct: 223 VFDISALEKDGLLGAELRILRKKPSDTAKPAAPGGGRAAQ----LKLSSCPSGRQPASLL 278

Query: 187 VSGEIYGTN-SEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSA 245
               + G + S WE FD+    R ++ S     +LE     +   A D     L  D +A
Sbjct: 279 DVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAW---ERGRAVDLRG--LGFDRAA 333

Query: 246 QNKHNP-LLIVFSDDQSSD------KERKEELNEMISHEQLPELDNLGLDSFSSGPGEEA 298
           +  H   L +VF   +  D      K R  + ++ + +E L          FS      A
Sbjct: 334 RQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTV-YEYL----------FSQRRKRRA 382

Query: 299 LLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNY 358
            L  R         R  +N K   C R  L+++FK++GWD WIIAP  YEA+ C G+C +
Sbjct: 383 PLATRQG------KRPSKNLKAR-CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEF 435

Query: 359 PLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK-GVVTYKFKYEGMA 417
           PL  HL PT HA+IQ L++  + +     CCVPT+L PISIL++D    V YK +YE M 
Sbjct: 436 PLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYK-QYEDMV 494

Query: 418 VSECGCR 424
           V  CGCR
Sbjct: 495 VESCGCR 501


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  129 bits (324), Expect = 5e-30
 Identities = 59/103 (57%), Positives = 71/103 (68%), Gaps = 2/103 (1%)

Query: 323 CKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQ 382
           C R PL++DFKE+GWD WIIAP  YEAY C G+C++PL  HL PT HAIIQ L++     
Sbjct: 349 CSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPD 408

Query: 383 KASKACCVPTKLEPISILYLD-KGVVTYKFKYEGMAVSECGCR 424
            A  +CCVP +L PISILY+D    V YK +YE M V  CGCR
Sbjct: 409 AAPASCCVPARLSPISILYIDAANNVVYK-QYEDMVVEACGCR 450


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  126 bits (317), Expect = 3e-29
 Identities = 97/369 (26%), Positives = 157/369 (42%), Gaps = 48/369 (13%)

Query: 72  PTQDSAKVDPPEYMLELYNKFATD--------RTSMPSANIIRSFKNEDLFSQPVSFNGL 123
           P         P +ML+LY+  A D           +  A+++ SF N     + +     
Sbjct: 64  PAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRALGHQEP 123

Query: 124 RKYPLLFNVS-IPHHEEVIMAELRLYTLVQ---RDRMIYDGVDRKITIFEVLESKGDNEG 179
                 F+++ IP  E V  AE R+Y +      +R ++      +++F+V++ + + E 
Sbjct: 124 HWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLH------VSMFQVVQEQSNRES 177

Query: 180 ERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRL 239
           +   L L +  +   +  W   DVT A   W         L +++E++   + D     L
Sbjct: 178 DLFFLDLQT--LRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGL 235

Query: 240 EIDTSAQNKHNPLLIVF-----SDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGP 294
            +   A     P ++ F     S  ++    R     +     +LP+ + L        P
Sbjct: 236 -LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRL--------P 286

Query: 295 GEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRG 354
           G           I+D    +R +     C+R  LY+ F+++GW  W+IAP GY AY C G
Sbjct: 287 G-----------IFDD---VRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEG 332

Query: 355 VCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYE 414
            C++PL   +  T HAI+Q+LVHL       KACC PTKL   S+LY D        K+ 
Sbjct: 333 ECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHR 392

Query: 415 GMAVSECGC 423
            M V  CGC
Sbjct: 393 NMVVKACGC 401


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  124 bits (311), Expect = 2e-28
 Identities = 87/343 (25%), Positives = 146/343 (42%), Gaps = 45/343 (13%)

Query: 93  ATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLV 151
           A D   +  A+++ SF N   + +  S          FN+S IP  E V  AE R+Y   
Sbjct: 203 AQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIY--- 259

Query: 152 QRDRMI--YDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRR 209
            +D ++  +      I+I++VL+     + +  + +L +  ++ +   W  FD+T     
Sbjct: 260 -KDCVMGSFKNQTFLISIYQVLQEHQHRDSD--LFLLDTRVVWASEEGWLEFDITATSNL 316

Query: 210 WQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVF---------SDDQ 260
           W  +      L++ + ++        +  L +         P ++ F         +   
Sbjct: 317 WVVTPQHNMGLQLSVVTRDGVHVHPRAAGL-VGRDGPYDKQPFMVAFFKVSEVHVRTTRS 375

Query: 261 SSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKG 320
           +S + R++  N     + +  + +     ++S   + A                      
Sbjct: 376 ASSRRRQQSRNRSTQSQDVARVSSAS--DYNSSELKTA---------------------- 411

Query: 321 NYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKN 380
             C++  LY+ F+++GW  WIIAP GY A  C G C++PL  H+  T HAI+Q LVHL N
Sbjct: 412 --CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN 469

Query: 381 SQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
            +   K CC PTKL  IS+LY D        KY  M V  CGC
Sbjct: 470 PEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  124 bits (310), Expect = 2e-28
 Identities = 96/369 (26%), Positives = 156/369 (42%), Gaps = 48/369 (13%)

Query: 72  PTQDSAKVDPPEYMLELYNKFATD--------RTSMPSANIIRSFKNEDLFSQPVSFNGL 123
           P         P +ML+LY+  A D           +  A+++ SF N     + +     
Sbjct: 64  PAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGHQEP 123

Query: 124 RKYPLLFNVS-IPHHEEVIMAELRLYTLVQ---RDRMIYDGVDRKITIFEVLESKGDNEG 179
                 F+++ IP  E V  AE R+Y +      +R ++      +++F+V++ + + E 
Sbjct: 124 HWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLH------VSMFQVVQEQSNRES 177

Query: 180 ERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRL 239
           +   L L +  +   +  W   DVT A   W         L +++E++   + D     L
Sbjct: 178 DLFFLDLQT--LRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGL 235

Query: 240 EIDTSAQNKHNPLLIVF-----SDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGP 294
            +   A     P ++ F     S  ++    R     +     +LP+ + L        P
Sbjct: 236 -LGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRL--------P 286

Query: 295 GEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRG 354
           G           I+D    +  +     C+R  LY+ F+++GW  W+IAP GY AY C G
Sbjct: 287 G-----------IFDD---VHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEG 332

Query: 355 VCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYE 414
            C++PL   +  T HAI+Q+LVHL       KACC PTKL   S+LY D        K+ 
Sbjct: 333 ECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHR 392

Query: 415 GMAVSECGC 423
            M V  CGC
Sbjct: 393 NMVVKACGC 401


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 43/105 (40%), Positives = 57/105 (54%), Gaps = 1/105 (0%)

Query: 319 KGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHL 378
           +   C++    +DF  IGW SWII P  Y AY C G C  P+ E   PT HA IQ+L+  
Sbjct: 243 RSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKR 302

Query: 379 KNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
               +    CC P K +P+S+LY+D G V     ++ M V ECGC
Sbjct: 303 YQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLD-HHKDMIVEECGC 346



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 25/68 (36%), Positives = 36/68 (52%), Gaps = 13/68 (19%)

Query: 81  PPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEE 139
           P  YML LY      R  +P A+IIRS + ED     V+ +G + +   F+ S +   E+
Sbjct: 40  PLAYMLSLY------RDPLPRADIIRSLQAED-----VAVDG-QNWTFAFDFSFLSQQED 87

Query: 140 VIMAELRL 147
           +  AELRL
Sbjct: 88  LAWAELRL 95


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 69/236 (29%), Positives = 106/236 (44%), Gaps = 27/236 (11%)

Query: 195 NSEWETFDVTDAIRR--WQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNP- 251
           ++ W+  D+T  +++  W   G    +L    + + D      SG LE+     +     
Sbjct: 178 SNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKD------SGGLELWHGTSSLDIAF 231

Query: 252 LLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDST 311
           LL+ F+D   S ++ K           LP     G++ F          +    I  + T
Sbjct: 232 LLLYFNDTHKSIRKAKF----------LPR----GMEEFMERESLLRRTRQADGISAEVT 277

Query: 312 ARIRRNA--KGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKH 369
           A   +++  + N C   P  I F+++GWD WIIAPP Y    C+G C   L + L    H
Sbjct: 278 ASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNH 337

Query: 370 AIIQALVHLKNSQKASKACCVPTKLEPISILYLD-KGVVTYKFKYEGMAVSECGCR 424
           AIIQ L++    Q   +  CVP K  PIS+L ++  G + YK +YEGM    C CR
Sbjct: 338 AIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEANGSILYK-EYEGMIAESCTCR 392


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 49/124 (39%), Positives = 68/124 (54%), Gaps = 11/124 (8%)

Query: 312 ARIRRNAK-------GNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHL 364
           AR RR+A+       G  C+   LY+ F+E+GW  W+IAP G+ A  C+G C  P+A   
Sbjct: 249 ARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSG 308

Query: 365 T----PTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE 420
           +       HA+++AL+H      A   CCVP +L PIS+L+ D        +YE M V E
Sbjct: 309 SGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDE 368

Query: 421 CGCR 424
           CGCR
Sbjct: 369 CGCR 372


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 45/103 (43%), Positives = 61/103 (59%), Gaps = 1/103 (0%)

Query: 321 NYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKN 380
           N C R  L+I+F+++GW  WIIAP G+ A  C G C + L   L  + +A +QAL+H  +
Sbjct: 262 NLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVD 321

Query: 381 SQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
            +   +A C+PTKL PIS+LY D         YE M V ECGC
Sbjct: 322 PE-IPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 76/259 (29%), Positives = 107/259 (41%), Gaps = 44/259 (16%)

Query: 178 EGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSG 237
           +GER+ L+L    +    S W  F V+ +I+R    G S+  L+V I  +  +   AS  
Sbjct: 198 KGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSS--LDVRIACEQCQESGASLV 255

Query: 238 RLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEE 297
            L                        K++KEE  E    ++       G D         
Sbjct: 256 LL----------------------GKKKKKEEEGE--GKKKGGGEGGAGADE-EKEQSHR 290

Query: 298 ALLQMRSNIIYDSTARIRR-----NAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYEC 352
             L +++    D   R RR     + K N C +   ++ FK+IGW+ WIIAP GY A  C
Sbjct: 291 PFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYC 350

Query: 353 RGVC--------NYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK 404
            G C           L+ H T   H  ++      N     K+CCVPTKL P+S+LY D 
Sbjct: 351 EGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFAN----LKSCCVPTKLRPMSMLYYDD 406

Query: 405 GVVTYKFKYEGMAVSECGC 423
           G    K   + M V ECGC
Sbjct: 407 GQNIIKKDIQNMIVEECGC 425


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 42/114 (36%), Positives = 61/114 (53%), Gaps = 1/114 (0%)

Query: 312 ARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAI 371
           AR ++  +   C R  L +DF +IGW  WII+P  ++AY C G C +P+ + L P+ HA 
Sbjct: 359 ARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHAT 418

Query: 372 IQALVHLKNSQKA-SKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424
           IQ++V          + CCVP K+  +SIL+ D+        Y  M V  C CR
Sbjct: 419 IQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 5/135 (3%)

Query: 295 GEEALLQMRSNIIYDST----ARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAY 350
           G+E  +     + +D      AR ++  +   C R  L +DF +IGW+ WII+P  ++AY
Sbjct: 344 GQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAY 403

Query: 351 ECRGVCNYPLAEHLTPTKHAIIQALVHLKN-SQKASKACCVPTKLEPISILYLDKGVVTY 409
            C G C +P+ + + P+ HA IQ++V          + CCVP K+  + +L+LD+     
Sbjct: 404 YCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVV 463

Query: 410 KFKYEGMAVSECGCR 424
              Y  M+V  C CR
Sbjct: 464 LKVYPNMSVDTCACR 478


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 55/142 (38%), Positives = 72/142 (50%), Gaps = 17/142 (11%)

Query: 291 SSGPGEEALLQMRSNIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWII 342
           S GPG E L       + ++T R RRN        +  + C R PL +DF+  GWD WII
Sbjct: 273 SLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWD-WII 331

Query: 343 APPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL 402
           AP  Y+A  C G C Y   +   P  H + QA     N + ++  CC PTK+ PI++LY 
Sbjct: 332 APKRYKANYCSGQCEYMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYF 385

Query: 403 -DKGVVTYKFKYEGMAVSECGC 423
            DK  + Y  K  GM V  CGC
Sbjct: 386 NDKQQIIYG-KIPGMVVDRCGC 406


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 97/409 (23%), Positives = 175/409 (42%), Gaps = 72/409 (17%)

Query: 55  LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNK---FATDRTSMPSANIIRSFKNE 111
           +++++ + L  L L+  P       + P  ++ +YN       ++ S  +A   R   +E
Sbjct: 37  IEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDE 96

Query: 112 DLFSQPV----------SFNGL-----RKYPLLFNVSIPHHEE----VIMAELRLYTLVQ 152
           + +++ V          S N +     R Y  +    +   E+    ++ AE R++ L  
Sbjct: 97  EYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQN 156

Query: 153 RDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSE--WETFDVTDAIRRW 210
               +    +++I ++++L+SK      +     +  ++  T +E  W +FDVTDA+  W
Sbjct: 157 PKARV---PEQRIELYQILKSKDLTSPTQRY---IDSKVVKTRAEGEWLSFDVTDAVHEW 210

Query: 211 --QKSGSSTHQLEVH-------------IESKHDEAEDASSGRLEIDTSAQNKHNPLLIV 255
              K  +   ++ +H             I +K +E E   +G   ID ++          
Sbjct: 211 LHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG---IDGTSTYT------- 260

Query: 256 FSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIR 315
            S DQ + K  +++ +    H  L  L +  L+S  +   ++  L           A   
Sbjct: 261 -SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALD---------AAYCF 310

Query: 316 RNAKGNYCKRTPLYIDFK-EIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQA 374
           RN + N C R PLYIDFK ++GW  WI  P GY A  C G C Y  +   + T+H+ + +
Sbjct: 311 RNVQDNCCLR-PLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWS---SDTQHSRVLS 365

Query: 375 LVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
           L +  N + ++  CCV   LEP++ILY   G      +   M V  C C
Sbjct: 366 LYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVKSCKC 413


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 80/302 (26%), Positives = 135/302 (44%), Gaps = 50/302 (16%)

Query: 140 VIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSE-- 197
           ++ AE R++ L      +    +++I ++++L+SK      +     +  ++  T +E  
Sbjct: 172 LVKAEFRVFRLQNPKARV---PEQRIELYQILKSKDLTSPTQRY---IDSKVVKTRAEGE 225

Query: 198 WETFDVTDAIRRW--QKSGSSTHQLEVH-------------IESKHDEAEDASSGRLEID 242
           W +FDVTDA+  W   K  +   ++ +H             I +K +E E   +G   ID
Sbjct: 226 WLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG---ID 282

Query: 243 TSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQM 302
            ++           S DQ + K  +++ +    H  L  L +  L+S  +   ++  L  
Sbjct: 283 GTSTYT--------SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALD- 333

Query: 303 RSNIIYDSTARIRRNAKGNYCKRTPLYIDFK-EIGWDSWIIAPPGYEAYECRGVCNYPLA 361
                    A   RN + N C R PLYIDFK ++GW  WI  P GY A  C G C Y  +
Sbjct: 334 --------AAYCFRNVQDNCCLR-PLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWS 383

Query: 362 EHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSEC 421
              + T+H+ + +L +  N + ++  CCV   LEP++ILY   G      +   M V  C
Sbjct: 384 ---SDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY-IGKTPKIEQLSNMIVKSC 439

Query: 422 GC 423
            C
Sbjct: 440 KC 441


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 75/277 (27%), Positives = 116/277 (41%), Gaps = 45/277 (16%)

Query: 162 DRKITIFEVLESKGDNEGERNMLVLVSGEIYGTN--SEWETFDVTDAIRRWQKSGSSTHQ 219
           +++I +F++L        +R     + G+   T   +EW +FDVTD +R W     S   
Sbjct: 165 EQRIELFQILRPDEHIAKQR----YIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLG 220

Query: 220 LEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD----------KERKEE 269
           LE+ I       +             +N H  + I F    + D          K++K+ 
Sbjct: 221 LEISIHCPCHTFQPNGD-------ILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDH 273

Query: 270 LNEMISHEQLP--ELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTP 327
            N  +    +P   LDN G        G+     + +N  +       RN + N C R P
Sbjct: 274 HNPHLILMMIPPHRLDNPGQG------GQRKKRALDTNYCF-------RNLEENCCVR-P 319

Query: 328 LYIDFKE-IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASK 386
           LYIDF++ +GW  W+  P GY A  C G C Y  +     T H+ +  L +  N + ++ 
Sbjct: 320 LYIDFRQDLGW-KWVHEPKGYYANFCSGPCPYLRS---ADTTHSTVLGLYNTLNPEASAS 375

Query: 387 ACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
            CCVP  LEP++ILY   G      +   M V  C C
Sbjct: 376 PCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 411


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 2/103 (1%)

Query: 323 CKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEH--LTPTKHAIIQALVHLKN 380
           C R   Y+DF+E+GW  WI+ P GY+   C G C   LA    +  + H+ + +L+   N
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANN 306

Query: 381 SQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC 423
              AS +CCVPT   P+S+LYLD      K     M V  CGC
Sbjct: 307 PWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 48/139 (34%), Positives = 66/139 (47%), Gaps = 15/139 (10%)

Query: 293 GPGEEALLQMRSNIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAP 344
           GPGE+ L       + D+  R RR+        +  + C R PL +DF+  GWD WIIAP
Sbjct: 243 GPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAP 301

Query: 345 PGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK 404
             Y+A  C G C +   +    T       LVH  N + ++  CC PTK+ PI++LY + 
Sbjct: 302 KRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNG 355

Query: 405 GVVTYKFKYEGMAVSECGC 423
                  K   M V  CGC
Sbjct: 356 KEQIIYGKIPAMVVDRCGC 374


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 50/143 (34%), Positives = 69/143 (48%), Gaps = 16/143 (11%)

Query: 294 PGEEA-----LLQMRSNIIYDSTARIRR-----NAKGNYCKRTPLYIDFKEIGWDSWIIA 343
           PGEE+     ++Q R   + DS  RIR+     + + N C R   +IDF+ IGW+ WIIA
Sbjct: 267 PGEESHRPFVVVQAR---LGDSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIA 323

Query: 344 PPGYEAYECRGVCNYPLA--EHLTPTKHAIIQALVHLKNSQKAS-KACCVPTKLEPISIL 400
           P GY    C G C   LA       + H  +     ++     +  +CC+PTKL  +S+L
Sbjct: 324 PTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSML 383

Query: 401 YLDKGVVTYKFKYEGMAVSECGC 423
           Y D      K     M V ECGC
Sbjct: 384 YFDDEYNIVKRDVPNMIVEECGC 406


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 79/381 (20%), Positives = 145/381 (38%), Gaps = 54/381 (14%)

Query: 84  YMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNG---------LRKYPLLFNVSI 134
           YM +LY  +AT +  +P +N    +    LF+                L    LLFN+  
Sbjct: 88  YMKKLYKTYAT-KEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDR 146

Query: 135 PHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNE--GERNMLVLVSGEI- 191
               E ++  + LY +   + + +    + +    + E K  +   G        + +  
Sbjct: 147 ITTVEHLLKSVLLYNI--NNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFE 204

Query: 192 YGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAE--DASSGRLEI-------- 241
           +G   +W   DVT  ++    S   +  + ++     D+ E   A +G   +        
Sbjct: 205 FGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLI 264

Query: 242 ----DTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPE-------LDNLGLDSF 290
               DTSAQ  H+   + +    S   +++  L+     E+  E           G ++ 
Sbjct: 265 LYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRGQETV 324

Query: 291 SS------GPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAP 344
           SS      GP    L +     +             N C+     + F ++ WD+WI+AP
Sbjct: 325 SSELKKPLGPASFNLSEYFRQFLLPQ----------NECELHDFRLSFSQLKWDNWIVAP 374

Query: 345 PGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLD- 403
             Y    C+G C   +        H ++Q +++ K      +  CVP K  P+S+L ++ 
Sbjct: 375 HRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEP 434

Query: 404 KGVVTYKFKYEGMAVSECGCR 424
            G + YK +YE M  ++C CR
Sbjct: 435 DGSIAYK-EYEDMIATKCTCR 454


>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
          Length = 390

 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 105/401 (26%), Positives = 157/401 (39%), Gaps = 89/401 (22%)

Query: 55  LQSMKDEFLKTLNLSDIPTQDSAKVDP-PEYMLELYNKFATDRTSMPSAN---------- 103
           +++++ + L  L L+  P+Q      P PE +L LYN    DR +  SA           
Sbjct: 46  IEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNS-TRDRVAGESAEPEPEPEADYY 104

Query: 104 -------IIRSFKNE--DLFSQPVSFNGLRKYPLLFNVS-----IPHHEEVIMAELRLYT 149
                  ++    NE  D F Q           + FN S     +P    +  AELRL  
Sbjct: 105 AKEVTRVLMVETHNEIYDKFKQST-----HSIYMFFNTSELREAVPEPVLLSRAELRLLR 159

Query: 150 LVQRDRMIYDGVDRKITIFEVLESKGDNEGER---NMLVLVSGEIYGTNSEWETFDVTDA 206
           L  +       V++ + +++    K  N   R   N L+  S      + EW +FDVT  
Sbjct: 160 LKLK-------VEQHVELYQ----KYSNNSWRYLSNRLLAPSD-----SPEWLSFDVTGV 203

Query: 207 IRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKER 266
           +R+W   G    ++E    S H    D+    L++D +           F+  +  D   
Sbjct: 204 VRQWLSRGG---EIEGFRLSAHCSC-DSRDNTLQVDING----------FTTGRRGDLAT 249

Query: 267 KEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRT 326
              +N          L+        S     AL    +N  + ST +       N C R 
Sbjct: 250 IHGMNRPFLLLMATPLERA--QHLQSSRHRRAL---DTNYCFSSTEK-------NCCVRQ 297

Query: 327 PLYIDF-KEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKAS 385
            LYIDF K++GW  WI  P GY A  C G C Y  +     T+++ + AL +  N   ++
Sbjct: 298 -LYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWS---LDTQYSKVLALYNQHNPGASA 352

Query: 386 KACCVPTKLEPISILYLDKGVVTYKFKYE---GMAVSECGC 423
             CCVP  LEP+ I+Y     V  K K E    M V  C C
Sbjct: 353 APCCVPQALEPLPIVY----YVGRKPKVEQLSNMIVRSCKC 389


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,141,594
Number of Sequences: 37866
Number of extensions: 705046
Number of successful extensions: 1926
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1823
Number of HSP's gapped (non-prelim): 88
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.