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Search of human proteins with 76443679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
(755 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ... 1584 0.0
gi|4505579 furin preproprotein [Homo sapiens] 782 0.0
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 615 e-176
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 615 e-176
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 608 e-174
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 607 e-173
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 607 e-173
gi|20336188 paired basic amino acid cleaving system 4 isoform e ... 587 e-167
gi|27894285 paired basic amino acid cleaving system 4 isoform f ... 587 e-167
gi|20336190 paired basic amino acid cleaving system 4 isoform d ... 587 e-167
gi|20336242 proprotein convertase subtilisin/kexin type 1 prepro... 549 e-156
gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo ... 485 e-137
gi|20336186 paired basic amino acid cleaving system 4 isoform c ... 479 e-135
gi|20336248 proprotein convertase subtilisin/kexin type 7 prepro... 422 e-118
gi|108773804 Fraser syndrome 1 [Homo sapiens] 51 5e-06
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 47 9e-05
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 46 1e-04
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 45 2e-04
gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Ho... 37 0.088
gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Ho... 34 0.57
gi|134031945 SCO-spondin [Homo sapiens] 34 0.57
gi|41327736 epidermal growth factor receptor isoform d precursor... 33 0.98
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 32 1.7
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 32 1.7
gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens] 32 2.2
gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo ... 32 2.2
gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo ... 32 2.2
gi|118582257 vesicular acetylcholine transporter [Homo sapiens] 32 2.2
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 32 2.2
gi|4506143 neurotrypsin precursor [Homo sapiens] 32 2.2
>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
sapiens]
Length = 755
Score = 1584 bits (4102), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVN 60
MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVN
Sbjct: 1 MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVN 60
Query: 61 LGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTD 120
LGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTD
Sbjct: 61 LGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTD 120
Query: 121 PWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDF 180
PWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDF
Sbjct: 121 PWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDF 180
Query: 181 NDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVI 240
NDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVI
Sbjct: 181 NDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVI 240
Query: 241 EAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGN 300
EAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGN
Sbjct: 241 EAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGN 300
Query: 301 GGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTD 360
GGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTD
Sbjct: 301 GGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTD 360
Query: 361 LHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNG 420
LHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNG
Sbjct: 361 LHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNG 420
Query: 421 VGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACA 480
VGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACA
Sbjct: 421 VGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACA 480
Query: 481 GLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMS 540
GLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMS
Sbjct: 481 GLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMS 540
Query: 541 THFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRD 600
THFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRD
Sbjct: 541 THFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRD 600
Query: 601 TEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCR 660
TEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCR
Sbjct: 601 TEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCR 660
Query: 661 GGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLG 720
GGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLG
Sbjct: 661 GGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLG 720
Query: 721 GPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT 755
GPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT
Sbjct: 721 GPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT 755
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 782 bits (2020), Expect = 0.0
Identities = 388/692 (56%), Positives = 476/692 (68%), Gaps = 29/692 (4%)
Query: 33 IYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLH 92
++ ++WAV++ G +ARK GF+NLG IF G Y+H HRGV ++SL+PH
Sbjct: 29 VFTNTWAVRIPGGPAVANSVARKHGFLNLGQIF--GDYYHFWHRGVTKRSLSPHRPRHSR 86
Query: 93 LKKNPKVQWFQQQTLQRRVKRSVVV-PTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQG 151
L++ P+VQW +QQ +RR KR V PTDP F +QWY++ Q DL++ AW+QG +G G
Sbjct: 87 LQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHG 146
Query: 152 IVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMA 211
IVVS+LDDGIEK+HPDL NYDP AS+D ND DPDPQPRYT +NRHGTRCAGEVAA+A
Sbjct: 147 IVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA 206
Query: 212 NNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGP 271
NNG CGVGVA+NARIGGVRMLDG +TD +EA+SL L P HIHIYSASWGPEDDG+TVDGP
Sbjct: 207 NNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGP 266
Query: 272 GILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRV 331
L EAF RGV++GRGGLG++F+WASGNGG +D+CNCDGYTNSI+TLS+ S TQ G V
Sbjct: 267 ARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNV 326
Query: 332 PWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANP 391
PWYSEAC+STL TTYSSG + QIVTTDL CT+ HTGTSASAPLAAG+IAL LEAN
Sbjct: 327 PWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANK 386
Query: 392 FLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQP 451
LTWRDMQHLVV+ SKPAHL A DW TNGVGR+VSH YGYGLLDAG +V A+ W P
Sbjct: 387 NLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAP 446
Query: 452 QRKCAVRVQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLT 511
QRKC + + + P I + +R+ V+AC G N I LEH QA+LTLSY+RRGDL I L
Sbjct: 447 QRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLV 506
Query: 512 SPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRY 571
SPMGTRSTL+A RP D S +G+N+W FM+TH WDE+P G W L +EN N GTL ++
Sbjct: 507 SPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKF 566
Query: 572 TLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNH- 630
TL+LYGTA + P P+ SS C + C C+ + + C+ +CPP F
Sbjct: 567 TLVLYGTAPE--GLPVPPE--SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQV 622
Query: 631 --TRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMG--- 685
T T T + VC+ CHASC TC+G + DC SCP ++LD + +C
Sbjct: 623 LDTHYSTENDVETIRAS--VCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQ 680
Query: 686 --------------PTTPDSRPRLRAAACPHH 703
P ++ RLRA P H
Sbjct: 681 SSRESPPQQQPPRLPPEVEAGQRLRAGLLPSH 712
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 615 bits (1585), Expect = e-176
Identities = 335/745 (44%), Positives = 443/745 (59%), Gaps = 80/745 (10%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580
D+S EG+ NW FM+ H W E +G WTL +++ G L ++L+LYGTAE
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
Query: 581 --------------DMTARPTGPQVTSSACVQ-------RDTEGLC------QACDGP-- 611
+++A P + + Q D G+C + CDGP
Sbjct: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNA 696
Query: 612 -------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTC 659
+ LG + C++ CP +F T A R C CH C TC
Sbjct: 697 DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AARRCRRCHKGCETC 743
Query: 660 RGGSPRDCTSCPPSSTLDQQQGSCM 684
+ C SC Q+ +C+
Sbjct: 744 SSRAATQCLSCRRGFYHHQEMNTCV 768
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 615 bits (1585), Expect = e-176
Identities = 335/745 (44%), Positives = 443/745 (59%), Gaps = 80/745 (10%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580
D+S EG+ NW FM+ H W E +G WTL +++ G L ++L+LYGTAE
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
Query: 581 --------------DMTARPTGPQVTSSACVQ-------RDTEGLC------QACDGP-- 611
+++A P + + Q D G+C + CDGP
Sbjct: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTGVCHPECGDKGCDGPNA 696
Query: 612 -------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTC 659
+ LG + C++ CP +F T A R C CH C TC
Sbjct: 697 DQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AARRCRRCHKGCETC 743
Query: 660 RGGSPRDCTSCPPSSTLDQQQGSCM 684
+ C SC Q+ +C+
Sbjct: 744 SSRAATQCLSCRRGFYHHQEMNTCV 768
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 608 bits (1568), Expect = e-174
Identities = 320/693 (46%), Positives = 414/693 (59%), Gaps = 40/693 (5%)
Query: 30 RAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGH 89
R +Y + WAV+++ G E R+A K+GF+N+G I Y+H H +++S+ G
Sbjct: 31 RTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGT 90
Query: 90 RLHLKKNPKVQWFQQQTLQRRVKRSVVVP-------TDPWFSKQWYMNSE-----AQPDL 137
+ PKV+W QQQ +++R KR DP + WYM+ Q D+
Sbjct: 91 HSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDM 150
Query: 138 SILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKEN 197
+I AW +G +G+ IVV++LDDGIE+ HPDL NYD LAS D N D DP PRY S EN
Sbjct: 151 NIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNEN 210
Query: 198 RHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSA 257
+HGTRCAGEVAA ANN C VG+AFNA+IGGVRMLDG +TD++EA+S+S PQH+HIYSA
Sbjct: 211 KHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSA 270
Query: 258 SWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSI 317
SWGP+DDG+TVDGP LTR+AF GV GR GLG++F+WASGNGG D+C+CDGYTNSI
Sbjct: 271 SWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSI 330
Query: 318 HTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAP 377
+T+S+ ST + G+ PWY E C+STL TTYSSG + D +I+TTDL CTD HTGTSASAP
Sbjct: 331 YTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAP 390
Query: 378 LAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAG 437
+AAG+IALALEANPFLTWRD+QH++VR S+ HL A DW+TN G +VSH YG+GL+DA
Sbjct: 391 MAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAE 450
Query: 438 LLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRE--NVSACAGLHN-SIRSLEHVQA 494
+V A W Q C + I P +R S C+ N + LEHV
Sbjct: 451 AMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVV 510
Query: 495 QLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTL 554
++T+++ RRGDL I LTSP GTRS L+A R D S EG+ NW FM+ H W E G W L
Sbjct: 511 RITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVL 570
Query: 555 GL----ENKGYYFNTGTLYRYTLLLYGTA-----------------EDMTARPTGPQVTS 593
+ + G L ++L+LYGT+ PT T
Sbjct: 571 EVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTE 630
Query: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAG--PGHTAAPALRVCSS 651
D E CDGP CL Y + N+TR+ + PGH A R C
Sbjct: 631 DYAGPCDPECSEVGCDGPGPDHCNDCLHYY-YKLKNNTRICVSSCPPGHYHADKKR-CRK 688
Query: 652 CHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
C +C +C G C SC L+++ SC+
Sbjct: 689 CAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV 721
Score = 40.0 bits (92), Expect = 0.008
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 3/53 (5%)
Query: 640 HTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSC-MGPTTPDS 691
H++ + C C SC TC G ++CTSCP LD G C MG D+
Sbjct: 826 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD--LGMCQMGAICKDA 876
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 607 bits (1565), Expect = e-173
Identities = 336/758 (44%), Positives = 442/758 (58%), Gaps = 93/758 (12%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580
D+S EG+ NW FM+ H W E +G WTL +++ G L ++L+LYGTAE
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
Query: 581 --------------DMTA----RPTGPQVTSSACVQRDTE----------------GLC- 605
+++A P S V D E +C
Sbjct: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCH 696
Query: 606 -----QACDGP---------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPAL 646
+ CDGP + LG + C++ CP +F T A
Sbjct: 697 PECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AA 743
Query: 647 RVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
R C CH C TC + C SC Q+ +C+
Sbjct: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCV 781
Score = 38.9 bits (89), Expect = 0.018
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 15/108 (13%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRL---VTAGP-GHTAAPALRVCSSCHASCYTCR 660
C+ C A CL+ C F++H + VT P G A + + C CH SC C
Sbjct: 753 CETCSSRA---ATQCLS-CRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC- 807
Query: 661 GGSPRDCTSCPPSSTLDQQQGSCM---GPTTPDSRPRLRAAACPHHRC 705
P CT C +L +GSC+ P T +R C HH C
Sbjct: 808 VDEPEKCTVCKEGFSL--ARGSCIPDCEPGTYFDSELIRCGEC-HHTC 852
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 607 bits (1565), Expect = e-173
Identities = 336/758 (44%), Positives = 442/758 (58%), Gaps = 93/758 (12%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNT----GTLYRYTLLLYGTAE-- 580
D+S EG+ NW FM+ H W E +G WTL +++ G L ++L+LYGTAE
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHP 636
Query: 581 --------------DMTA----RPTGPQVTSSACVQRDTE----------------GLC- 605
+++A P S V D E +C
Sbjct: 637 YHTFSAHQSRSRMLELSAPELEPPKAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCH 696
Query: 606 -----QACDGP---------AYILGQL-----CLAYCPPRFFNHTRLVTAGPGHTAAPAL 646
+ CDGP + LG + C++ CP +F T A
Sbjct: 697 PECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDT-------------AA 743
Query: 647 RVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
R C CH C TC + C SC Q+ +C+
Sbjct: 744 RRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCV 781
Score = 38.9 bits (89), Expect = 0.018
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 15/108 (13%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRL---VTAGP-GHTAAPALRVCSSCHASCYTCR 660
C+ C A CL+ C F++H + VT P G A + + C CH SC C
Sbjct: 753 CETCSSRA---ATQCLS-CRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC- 807
Query: 661 GGSPRDCTSCPPSSTLDQQQGSCM---GPTTPDSRPRLRAAACPHHRC 705
P CT C +L +GSC+ P T +R C HH C
Sbjct: 808 VDEPEKCTVCKEGFSL--ARGSCIPDCEPGTYFDSELIRCGEC-HHTC 852
>gi|20336188 paired basic amino acid cleaving system 4 isoform e
preproprotein [Homo sapiens]
Length = 623
Score = 587 bits (1512), Expect = e-167
Identities = 296/572 (51%), Positives = 385/572 (67%), Gaps = 20/572 (3%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLEN 558
D+S EG+ NW FM+ H W E +G WTL +++
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|27894285 paired basic amino acid cleaving system 4 isoform f
preproprotein [Homo sapiens]
Length = 664
Score = 587 bits (1512), Expect = e-167
Identities = 296/572 (51%), Positives = 385/572 (67%), Gaps = 20/572 (3%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLEN 558
D+S EG+ NW FM+ H W E +G WTL +++
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|20336190 paired basic amino acid cleaving system 4 isoform d
preproprotein [Homo sapiens]
Length = 652
Score = 587 bits (1512), Expect = e-167
Identities = 296/572 (51%), Positives = 385/572 (67%), Gaps = 20/572 (3%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRP--TPILP 468
L+A DW+ NG G +VSH YG+GL+DA LV A+ W Q C RP P++
Sbjct: 458 LKASDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQ 517
Query: 469 LIYIRENVSACAGLHNSIR--SLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPL 526
++ SACA H+ R LEHV + ++S+ RRGDL+I L SP GT+S L+A R L
Sbjct: 518 VLRTTALTSACAE-HSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLL 576
Query: 527 DVSTEGYNNWVFMSTHFWDENPQGVWTLGLEN 558
D+S EG+ NW FM+ H W E +G WTL +++
Sbjct: 577 DLSNEGFTNWEFMTVHCWGEKAEGQWTLEIQD 608
>gi|20336242 proprotein convertase subtilisin/kexin type 1
preproprotein [Homo sapiens]
Length = 753
Score = 549 bits (1414), Expect = e-156
Identities = 280/595 (47%), Positives = 381/595 (64%), Gaps = 19/595 (3%)
Query: 34 YVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHL 93
+V+ WA ++ G +A + G+ LG I ++ +H+ ++S + L
Sbjct: 31 FVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRL 90
Query: 94 KKNPKVQWFQQQTLQRRVKRSVVVPT------DPWFSKQWYMN----SEAQP--DLSILQ 141
+ +V W +QQ + R KRS + + DP +++QWY+ + A P DL ++
Sbjct: 91 SDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIP 150
Query: 142 AWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGT 201
W +G++G+G+V++VLDDG+E +H D++ANYDP ASYDFND D DP PRY P+ EN+HGT
Sbjct: 151 VWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGT 210
Query: 202 RCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGP 261
RCAGE+A ANN CGVGVA+N+++GG+RMLDG +TD IEA S+ P H+ IYSASWGP
Sbjct: 211 RCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGP 270
Query: 262 EDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLS 321
DDG+TV+GPG L ++AF GV +GR G G++F+WASGNGG DNC+CDGYT+SI+T+S
Sbjct: 271 NDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTIS 330
Query: 322 VGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAG 381
+ S +QQG PWY+E C+STL T+YSSG TD +I + DLH+ CT+ HTGTSASAPLAAG
Sbjct: 331 ISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAG 390
Query: 382 MIALALEANPFLTWRDMQHLVVRASKPAHL-QAEDWRTNGVGRQVSHHYGYGLLDAGLLV 440
+ ALALEANP LTWRDMQHLVV S+ L W+ NG G V+ +G+GLL+A LV
Sbjct: 391 IFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALV 450
Query: 441 DTA--RTWLPTQPQRKCAVR---VQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQ 495
D A RTW +++C V+ + R + I AC G N+I+SLEHVQ +
Sbjct: 451 DLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFE 510
Query: 496 LTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLG 555
T+ YSRRGDL ++LTS GT + L+A R D S G+ NW FMS H W ENP G WTL
Sbjct: 511 ATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLR 570
Query: 556 L-ENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACD 609
+ + G N G + + L+L+GT+ TS VQ D G+ + D
Sbjct: 571 ITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVD 625
>gi|20336244 proprotein convertase subtilisin/kexin type 2 [Homo
sapiens]
Length = 638
Score = 485 bits (1249), Expect = e-137
Identities = 262/576 (45%), Positives = 364/576 (63%), Gaps = 26/576 (4%)
Query: 26 WAPVRAPIYVSSWAVQVSQGNREVER-LARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLT 84
+A P++ + + V++ +G + R +A + GF F +G Y H H G+ +
Sbjct: 22 FASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLY-HFYHNGLAKAKRR 80
Query: 85 PHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV-------VVPTDPWFSKQWYMNSEAQPD- 136
H+ L+++P+V+ QQ R KR + DP F+KQWY+ + Q D
Sbjct: 81 RSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADG 140
Query: 137 -----LSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRY 191
L++ +AW G +G+G+ + ++DDGI+ HPDL +NY+ ASYDF+ DP P PRY
Sbjct: 141 TPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRY 200
Query: 192 TPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGT-ITDVIEAQSLSLQPQ 250
T N HGTRCAGEV+A ANN CGVGVA+N+++ G+RMLD +TD+IEA S+S PQ
Sbjct: 201 TDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQ 260
Query: 251 HIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNC 310
I IYSASWGP D+G+TVDGP LT +A GV KGRGG G++++WASG+GG YD+CNC
Sbjct: 261 LIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNC 319
Query: 311 DGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQ--IVTTDLHHGCTDQ 368
DGY +S+ T+S+ S GR Y E+C+STL +T+S+G +P+ + TTDL+ CT +
Sbjct: 320 DGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLR 379
Query: 369 HTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASK--PAHLQAEDWRTNGVGRQVS 426
H+GTSA+AP AAG+ ALALEAN LTWRDMQHL V SK H + WR NGVG + +
Sbjct: 380 HSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFN 439
Query: 427 HHYGYGLLDAGLLVDTARTWLPTQPQRKCAV--RVQS-RPTPILPLIYIRENVSACAGLH 483
H +GYG+LDAG +V A+ W T P+R V VQ P + + AC G
Sbjct: 440 HLFGYGVLDAGAMVKMAKDW-KTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKE 498
Query: 484 NSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTE-GYNNWVFMSTH 542
N +R LEHVQA +T++ +RRGDL I++TSPMGT+S L++ RP D ++ G++ W FM+TH
Sbjct: 499 NFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTH 558
Query: 543 FWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGT 578
W E+ +G WTL L G G L +TL+L+GT
Sbjct: 559 TWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594
>gi|20336186 paired basic amino acid cleaving system 4 isoform c
preproprotein [Homo sapiens]
Length = 487
Score = 479 bits (1232), Expect = e-135
Identities = 236/434 (54%), Positives = 303/434 (69%), Gaps = 15/434 (3%)
Query: 2 RPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNL 61
RP W R +L LAL P A P R P+Y + WAVQV G E +R+A G++NL
Sbjct: 42 RPLAPRPW-RWLLLLAL--PAACSAPPPR-PVYTNHWAVQVLGGPAEADRVAAAHGYLNL 97
Query: 62 GPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSV------ 115
G I Y+H H ++S G L+ +P+V+W QQQ ++RRVKR V
Sbjct: 98 GQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQA 157
Query: 116 VVPTDPWFSKQWYM-----NSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWA 170
+ DP +S WY+ NS + ++++ AW +G +G+ +VV++LDDGIE++HPDL
Sbjct: 158 LYFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAP 217
Query: 171 NYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVR 230
NYD ASYD N D DP PRY S EN+HGTRCAGEVAA ANN +C VG+A+NA+IGG+R
Sbjct: 218 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIR 277
Query: 231 MLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGL 290
MLDG +TDV+EA+SL ++P +I IYSASWGP+DDG+TVDGPG L ++AF G+ KGR GL
Sbjct: 278 MLDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGL 337
Query: 291 GTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGV 350
G++F+WASGNGG D C+CDGYTNSI+T+SV S T+ G PWY E CASTL TTYSSG
Sbjct: 338 GSIFVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA 397
Query: 351 ATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAH 410
+ +IVTTDL CTD HTGTS SAP+ AG+IALALEAN LTWRD+QHL+V+ S+PAH
Sbjct: 398 FYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAH 457
Query: 411 LQAEDWRTNGVGRQ 424
L+A DW+ NG G +
Sbjct: 458 LKASDWKVNGAGHK 471
>gi|20336248 proprotein convertase subtilisin/kexin type 7
preproprotein [Homo sapiens]
Length = 785
Score = 422 bits (1085), Expect = e-118
Identities = 253/648 (39%), Positives = 357/648 (55%), Gaps = 44/648 (6%)
Query: 5 PIALWLRLVLALALVRPRAVGWAPVRAPIYVS----SWAVQVS--QGNREVERL------ 52
P LWL L L L+ P +G A P SWAV + +G+ E E L
Sbjct: 18 PTCLWLELA-GLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLESLEGDGEEETLEQQADA 76
Query: 53 -ARKFGFVNLGPIFP-DGQYFHLR---HRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTL 107
A+ G VN G I G Y ++ HR ++ + L + V+W +Q L
Sbjct: 77 LAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV-LAGHEAVRWHSEQRL 135
Query: 108 QRRVKRSVVVPTDPWFSKQWYMNSEAQP--DLSILQAWSQGLSGQGIVVSVLDDGIEKDH 165
RR KRSV DP + +QW++N+ P D+++ W + ++G+G+ V V+DDG+E
Sbjct: 136 LRRAKRSVHF-NDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTI 194
Query: 166 PDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNAR 225
D+ NY P SYD N DPDP P N HGTRCAGE+AA+ NN FC VGVA+ +R
Sbjct: 195 QDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSR 254
Query: 226 IGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTK 285
I G+R+LDG +TD +EA + + Q IYS SWGP+DDG+TVDGP L + A + GV
Sbjct: 255 IAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIA 314
Query: 286 GRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTT 345
GR G G++F+ ASGNGG H DNCN DGY NSI+T+++G+ ++GR+P+Y+E CAS L T
Sbjct: 315 GRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVT 374
Query: 346 YSSGVATDPQIVTTDLH----HGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHL 401
+S G IVTTD GCT+ HTGTSA+APLAAGMIAL L+ P LTWRD+QH+
Sbjct: 375 FSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHI 434
Query: 402 VVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTW--LPTQPQRKCAVRV 459
+V + + +W TN G SH +G+GLL+A LV+ A+ W +P V
Sbjct: 435 IVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLK 494
Query: 460 QSRPTPILP-LIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRS 518
+++ P P + + NVS + +++LEHV +++++ RRG LE+ L P G S
Sbjct: 495 ENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMS 554
Query: 519 TLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKG-YYFNTGTLYRYTLLLYG 577
+ A R +D G+N+W F + W E +G + L + + G F G L ++ L LYG
Sbjct: 555 LIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYG 614
Query: 578 TAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPP 625
+ SA RD + L ++ Y+ L CPP
Sbjct: 615 S-------------VWSAVDIRDRQRLLESAMSGKYLHDDFALP-CPP 648
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 50.8 bits (120), Expect = 5e-06
Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 602 EGLCQACDGPAYILGQL---CLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYT 658
+G C ACD G CL + + ++ PG A A C CH SC +
Sbjct: 555 QGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCAS 614
Query: 659 CRGGSPRDCTSCPPSSTLDQQQGSCM 684
C G +P CT+C P L +QG C+
Sbjct: 615 CSGPTPSHCTACSPPKAL--RQGHCL 638
Score = 46.6 bits (109), Expect = 9e-05
Identities = 24/66 (36%), Positives = 31/66 (46%), Gaps = 16/66 (24%)
Query: 619 CLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQ 678
CLA C F+ L + G +C +CH SC+ C G SP +CT C PS L
Sbjct: 695 CLAQCRAHFY----LESTG----------ICEACHQSCFRCAGKSPHNCTDCGPSHVL-- 738
Query: 679 QQGSCM 684
G C+
Sbjct: 739 LDGQCL 744
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 7/95 (7%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTR-LVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
C +C GP C A PP+ L G G + VC +CH+SC C G +
Sbjct: 612 CASCSGPT---PSHCTACSPPKALRQGHCLPRCGEGFYSDHG--VCKACHSSCLACMGPA 666
Query: 664 PRDCTSC-PPSSTLDQQQGSCMGPTTPDSRPRLRA 697
P CT C P L +Q S +G + + + RA
Sbjct: 667 PSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRA 701
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 17/85 (20%)
Query: 600 DTEGLCQACDGPAYIL-GQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYT 658
+T +C C Y+L G C+ CP ++ C CH+SC T
Sbjct: 822 NTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERG---------------ACKKCHSSCRT 866
Query: 659 CRGGSPRDCTSCPPSSTLDQQQGSC 683
C+G P C+SC + L G+C
Sbjct: 867 CQGRGPFSCSSCDTNLVL-SHTGTC 890
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/103 (27%), Positives = 42/103 (40%), Gaps = 37/103 (35%)
Query: 600 DTEGLCQACD-----------------GPAYIL--GQLCLAYCPPRFFNHTRLVTAGPGH 640
++ G+C+AC GP+++L GQ CL+ CP +F+
Sbjct: 706 ESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQ-CLSQCPDGYFHQEGS------- 757
Query: 641 TAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSC 683
C+ CH +C C G DC SC P +L G+C
Sbjct: 758 --------CTECHPTCRQCHGPLESDCISCYPHISL--TNGNC 790
Score = 35.8 bits (81), Expect = 0.15
Identities = 22/95 (23%), Positives = 34/95 (35%), Gaps = 13/95 (13%)
Query: 590 QVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVC 649
Q ++ C D++ C +C P +L F + + P + + C
Sbjct: 907 QPCNTHCGSCDSQASCTSCRDPNKVL-----------LFGECQYESCAPQYYLDFSTNTC 955
Query: 650 SSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
C SC C G DC C L Q G+C+
Sbjct: 956 KECDWSCSACSGPLKTDCLQCMDGYVL--QDGACV 988
Score = 32.7 bits (73), Expect = 1.3
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 5/70 (7%)
Query: 604 LCQACDGPAYIL--GQLCLAYCPPRFFNHTRLV-TAGPGHTAAPALRVCSSCHASCYTCR 660
LC AC G C + PP H + V T G G C+ CH SC C
Sbjct: 464 LCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR--HSCAVCHESCAGCW 521
Query: 661 GGSPRDCTSC 670
G + + C +C
Sbjct: 522 GPTEKHCLAC 531
Score = 31.2 bits (69), Expect = 3.7
Identities = 23/78 (29%), Positives = 29/78 (37%), Gaps = 17/78 (21%)
Query: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCH 653
S C+Q C C GP +L C+ C G G+ A A C++C
Sbjct: 1006 SYCLQCQGPHECTRCKGPFLLLEAQCVQEC-------------GKGYFADHAKHKCTACP 1052
Query: 654 ASCYTCRGGSPRD-CTSC 670
C C S RD C C
Sbjct: 1053 QGCLQC---SHRDRCHLC 1067
Score = 30.4 bits (67), Expect = 6.3
Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 1/56 (1%)
Query: 596 CVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSS 651
C+Q C CD ++ LC+ C P F HT T G P+L V S
Sbjct: 1055 CLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCS-GKIHTPSLHVNGS 1109
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 46.6 bits (109), Expect = 9e-05
Identities = 33/113 (29%), Positives = 45/113 (39%), Gaps = 10/113 (8%)
Query: 577 GTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFF--NHTRLV 634
G D T P+ T S V+ C+ACD Q +C FF + +
Sbjct: 53 GNRFDHHCYKTCPEKTYSEAVE------CKACDSNCSSCDQNGCYWCEEGFFLLGGSCVR 106
Query: 635 TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPT 687
GPG + C SCH +C TC G +C+SC L +G C+ T
Sbjct: 107 KCGPGFYGDQEMGECESCHRACETCTGPGHDECSSC--QEGLQLLRGMCVHAT 157
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/146 (25%), Positives = 52/146 (35%), Gaps = 43/146 (29%)
Query: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRL-----------VTAGPGHTA 642
S C D G C C+ ++LG C+ C P F+ + GPGH
Sbjct: 80 SNCSSCDQNG-CYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDE 138
Query: 643 APA----------------------------LRVCSSCHASCYTCRGGSPRDCTSCPPSS 674
+ LR CH+SC TC GS CTSCP +
Sbjct: 139 CSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTC-NGSATLCTSCPKGA 197
Query: 675 TLDQQQGSCMGPTTPDSRPRLRAAAC 700
L Q +C+ + P +R+ +C
Sbjct: 198 YLLAQ--ACVSSCPQGTWPSVRSGSC 221
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 13/71 (18%)
Query: 602 EGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRG 661
E CQ C + +L C+ CP G+ A C+ CH+SC TC G
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPE-------------GYYADEDSNRCAHCHSSCRTCEG 522
Query: 662 GSPRDCTSCPP 672
R C SC P
Sbjct: 523 RHSRQCHSCRP 533
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/80 (23%), Positives = 31/80 (38%), Gaps = 11/80 (13%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C +++G +C + C G C CH SC C+G
Sbjct: 628 CLSCVWSYHLMGGICTSDC-----------LVGEYRVGEGEKFNCEKCHESCMECKGPGA 676
Query: 665 RDCTSCPPSSTLDQQQGSCM 684
++CT CP + L + C+
Sbjct: 677 KNCTLCPANLVLHMDESHCL 696
Score = 40.0 bits (92), Expect = 0.008
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 13/79 (16%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C + LG+ CL C G+ A + C C+ SC C+G P
Sbjct: 528 CHSCRPGWFQLGKECLLQCRE-------------GYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 665 RDCTSCPPSSTLDQQQGSC 683
DC SC L + +G C
Sbjct: 575 TDCLSCDRFFFLLRSKGEC 593
Score = 35.0 bits (79), Expect = 0.26
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 17/81 (20%)
Query: 605 CQACDGPAYILGQ-LCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
C+ C +++L LCL CP + + + C CH SC TC S
Sbjct: 379 CELCLESSWVLYDGLCLEECPAGTYYEKQT-------------KECRDCHKSCLTC--SS 423
Query: 664 PRDCTSCPPSSTLDQQQGSCM 684
CT+C ++ +GSCM
Sbjct: 424 SGTCTTCQKGLIMN-PRGSCM 443
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/80 (25%), Positives = 29/80 (36%), Gaps = 13/80 (16%)
Query: 604 LCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
LC +C AY+L Q C++ CP + R + C +C +C C G
Sbjct: 189 LCTSCPKGAYLLAQACVSSCPQGTWPSVRSGS-------------CENCTEACAICSGAD 235
Query: 664 PRDCTSCPPSSTLDQQQGSC 683
P L +G C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRC 255
Score = 33.9 bits (76), Expect = 0.57
Identities = 23/87 (26%), Positives = 29/87 (33%), Gaps = 3/87 (3%)
Query: 591 VTSSACVQRDT--EGLCQACDGPAY-ILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALR 647
V C +R EG+C+ C + + C P FF H +
Sbjct: 300 VCQENCPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSH 359
Query: 648 VCSSCHASCYTCRGGSPRDCTSCPPSS 674
C CH C C G DC C SS
Sbjct: 360 HCVPCHKDCLECSGPKADDCELCLESS 386
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 649 CSSCHASCYTCRGGSPRDCTSCPPSSTL 676
C CH C+ C G + C +CP +S L
Sbjct: 461 CKPCHVKCFHCMGPAEDQCQTCPMNSLL 488
Score = 33.9 bits (76), Expect = 0.57
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 14/73 (19%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAP-------ALRVCSSCHASCY 657
C+ C GP CL+ C FF L + G H + P + + C CH +C
Sbjct: 566 CKGCQGPR---PTDCLS-CDRFFF---LLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 658 TCRGGSPRDCTSC 670
C+G +C SC
Sbjct: 619 QCKGKGALNCLSC 631
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/113 (29%), Positives = 45/113 (39%), Gaps = 10/113 (8%)
Query: 577 GTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFF--NHTRLV 634
G D T P+ T S V+ C+ACD Q +C FF + +
Sbjct: 53 GNRFDHHCYKTCPEKTYSEAVE------CKACDSNCGSCDQNGCYWCEEGFFLLGGSCVR 106
Query: 635 TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPT 687
GPG + C SCH +C TC G +C+SC L +G C+ T
Sbjct: 107 KCGPGFYGDQEMGECESCHRACETCTGPGHDECSSC--QEGLQLLRGMCVHAT 157
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/146 (25%), Positives = 52/146 (35%), Gaps = 43/146 (29%)
Query: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRL-----------VTAGPGHTA 642
S C D G C C+ ++LG C+ C P F+ + GPGH
Sbjct: 80 SNCGSCDQNG-CYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDE 138
Query: 643 APA----------------------------LRVCSSCHASCYTCRGGSPRDCTSCPPSS 674
+ LR CH+SC TC GS CTSCP +
Sbjct: 139 CSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTC-NGSATLCTSCPKGA 197
Query: 675 TLDQQQGSCMGPTTPDSRPRLRAAAC 700
L Q +C+ + P +R+ +C
Sbjct: 198 YLLAQ--ACVSSCPQGTWPSVRSGSC 221
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 13/71 (18%)
Query: 602 EGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRG 661
E CQ C + +L C+ CP G+ A C+ CH+SC TC G
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPE-------------GYYADEDSNRCAHCHSSCRTCEG 522
Query: 662 GSPRDCTSCPP 672
R C SC P
Sbjct: 523 RHSRQCHSCRP 533
Score = 41.2 bits (95), Expect = 0.004
Identities = 19/80 (23%), Positives = 30/80 (37%), Gaps = 11/80 (13%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C +++G +C + C G C CH SC C+G
Sbjct: 628 CLSCVWSYHLMGGICTSDC-----------LVGEYRVGEGEKFNCEKCHESCMECKGPGA 676
Query: 665 RDCTSCPPSSTLDQQQGSCM 684
++CT CP + L C+
Sbjct: 677 KNCTLCPANLVLHMDDSHCL 696
Score = 40.0 bits (92), Expect = 0.008
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 13/79 (16%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C + LG+ CL C G+ A + C C+ SC C+G P
Sbjct: 528 CHSCRPGWFQLGKECLLQCRE-------------GYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 665 RDCTSCPPSSTLDQQQGSC 683
DC SC L + +G C
Sbjct: 575 TDCLSCDRFFFLLRSKGEC 593
Score = 35.0 bits (79), Expect = 0.26
Identities = 24/81 (29%), Positives = 33/81 (40%), Gaps = 17/81 (20%)
Query: 605 CQACDGPAYILGQ-LCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
C+ C +++L LCL CP G + C CH SC TC S
Sbjct: 379 CELCLESSWVLYDGLCLEECPA-------------GTYYEKETKECRDCHKSCLTC--SS 423
Query: 664 PRDCTSCPPSSTLDQQQGSCM 684
CT+C ++ +GSCM
Sbjct: 424 SGTCTTCQKGLIMN-PRGSCM 443
Score = 34.7 bits (78), Expect = 0.34
Identities = 19/73 (26%), Positives = 25/73 (34%), Gaps = 15/73 (20%)
Query: 602 EGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRG 661
E C+ C ++ +C CP F+ +R C CH C C G
Sbjct: 329 EKTCKECTPEFFLHDDMCHQSCPRGFYADSRH---------------CVPCHKDCLECSG 373
Query: 662 GSPRDCTSCPPSS 674
DC C SS
Sbjct: 374 PKADDCELCLESS 386
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/80 (25%), Positives = 29/80 (36%), Gaps = 13/80 (16%)
Query: 604 LCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
LC +C AY+L Q C++ CP + R + C +C +C C G
Sbjct: 189 LCTSCPKGAYLLAQACVSSCPQGTWPSVRSGS-------------CENCTEACAICSGAD 235
Query: 664 PRDCTSCPPSSTLDQQQGSC 683
P L +G C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRC 255
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 649 CSSCHASCYTCRGGSPRDCTSCPPSSTL 676
C CH C+ C G + C +CP +S L
Sbjct: 461 CKPCHVKCFHCMGPAEDQCQTCPMNSLL 488
Score = 33.9 bits (76), Expect = 0.57
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 14/73 (19%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAP-------ALRVCSSCHASCY 657
C+ C GP CL+ C FF L + G H + P + + C CH +C
Sbjct: 566 CKGCQGPR---PTDCLS-CDRFFF---LLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 658 TCRGGSPRDCTSC 670
C+G +C SC
Sbjct: 619 QCKGKGALNCLSC 631
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/146 (25%), Positives = 52/146 (35%), Gaps = 43/146 (29%)
Query: 594 SACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRL-----------VTAGPGHTA 642
S C D G C C+ ++LG C+ C P F+ + GPGH
Sbjct: 80 SNCGSCDQNG-CYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDE 138
Query: 643 APA----------------------------LRVCSSCHASCYTCRGGSPRDCTSCPPSS 674
+ LR CH+SC TC GS CTSCP +
Sbjct: 139 CSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTC-NGSATLCTSCPKGA 197
Query: 675 TLDQQQGSCMGPTTPDSRPRLRAAAC 700
L Q +C+ + P +R+ +C
Sbjct: 198 YLLAQ--ACVSSCPQGTWPSVRSGSC 221
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 13/71 (18%)
Query: 602 EGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRG 661
E CQ C + +L C+ CP G+ A C+ CH+SC TC G
Sbjct: 476 EDQCQTCPMNSLLLNTTCVKDCPE-------------GYYADEDSNRCAHCHSSCRTCEG 522
Query: 662 GSPRDCTSCPP 672
R C SC P
Sbjct: 523 RHSRQCHSCRP 533
Score = 41.2 bits (95), Expect = 0.004
Identities = 19/80 (23%), Positives = 30/80 (37%), Gaps = 11/80 (13%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C +++G +C + C G C CH SC C+G
Sbjct: 628 CLSCVWSYHLMGGICTSDC-----------LVGEYRVGEGEKFNCEKCHESCMECKGPGA 676
Query: 665 RDCTSCPPSSTLDQQQGSCM 684
++CT CP + L C+
Sbjct: 677 KNCTLCPANLVLHMDDSHCL 696
Score = 40.0 bits (92), Expect = 0.008
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 13/79 (16%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSP 664
C +C + LG+ CL C G+ A + C C+ SC C+G P
Sbjct: 528 CHSCRPGWFQLGKECLLQCRE-------------GYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 665 RDCTSCPPSSTLDQQQGSC 683
DC SC L + +G C
Sbjct: 575 TDCLSCDRFFFLLRSKGEC 593
Score = 35.0 bits (79), Expect = 0.26
Identities = 24/81 (29%), Positives = 33/81 (40%), Gaps = 17/81 (20%)
Query: 605 CQACDGPAYILGQ-LCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
C+ C +++L LCL CP G + C CH SC TC S
Sbjct: 379 CELCLESSWVLYDGLCLEECPA-------------GTYYEKETKECRDCHKSCLTC--SS 423
Query: 664 PRDCTSCPPSSTLDQQQGSCM 684
CT+C ++ +GSCM
Sbjct: 424 SGTCTTCQKGLIMN-PRGSCM 443
Score = 34.7 bits (78), Expect = 0.34
Identities = 19/73 (26%), Positives = 25/73 (34%), Gaps = 15/73 (20%)
Query: 602 EGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRG 661
E C+ C ++ +C CP F+ +R C CH C C G
Sbjct: 329 EKTCKECTPEFFLHDDMCHQSCPRGFYADSRH---------------CVPCHKDCLECSG 373
Query: 662 GSPRDCTSCPPSS 674
DC C SS
Sbjct: 374 PKADDCELCLESS 386
Score = 34.3 bits (77), Expect = 0.44
Identities = 20/80 (25%), Positives = 29/80 (36%), Gaps = 13/80 (16%)
Query: 604 LCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGS 663
LC +C AY+L Q C++ CP + R + C +C +C C G
Sbjct: 189 LCTSCPKGAYLLAQACVSSCPQGTWPSVRSGS-------------CENCTEACAICSGAD 235
Query: 664 PRDCTSCPPSSTLDQQQGSC 683
P L +G C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRC 255
Score = 33.9 bits (76), Expect = 0.57
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 649 CSSCHASCYTCRGGSPRDCTSCPPSSTL 676
C CH C+ C G + C +CP +S L
Sbjct: 461 CKPCHVKCFHCMGPAEDQCQTCPMNSLL 488
Score = 33.9 bits (76), Expect = 0.57
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 14/73 (19%)
Query: 605 CQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAP-------ALRVCSSCHASCY 657
C+ C GP CL+ C FF L + G H + P + + C CH +C
Sbjct: 566 CKGCQGPR---PTDCLS-CDRFFF---LLRSKGECHRSCPDHYYVEQSTQTCERCHPTCD 618
Query: 658 TCRGGSPRDCTSC 670
C+G +C SC
Sbjct: 619 QCKGKGALNCLSC 631
>gi|205360958 cysteine-rich with EGF-like domains 2 isoform b [Homo
sapiens]
Length = 353
Score = 36.6 bits (83), Expect = 0.088
Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 648 VCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
+C++C SC TC G + RDC C LD +G+C+
Sbjct: 195 ICTACDESCKTCSGLTNRDCGECEVGWVLD--EGACV 229
>gi|205360956 cysteine-rich with EGF-like domains 2 isoform a [Homo
sapiens]
Length = 402
Score = 33.9 bits (76), Expect = 0.57
Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 7/93 (7%)
Query: 597 VQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHT----RLVTAGPGHTAAPALRVCS-S 651
++ +T +C G + CL+ R H R PG+++ + S +
Sbjct: 188 LRNETHSICTVRTGLSDSYPPCCLSLGCWRGVGHAWIRGRNTHTQPGYSSRVWIAAFSPA 247
Query: 652 CHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCM 684
C SC TC G + RDC C LD +G+C+
Sbjct: 248 CDESCKTCSGLTNRDCGECEVGWVLD--EGACV 278
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 33.9 bits (76), Expect = 0.57
Identities = 28/100 (28%), Positives = 38/100 (38%), Gaps = 9/100 (9%)
Query: 588 GPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAY-CPPRFFNHTRLVTAGPGHTAAPAL 646
G + + AC Q +GL C+GP G++C A CP N T + A P
Sbjct: 3271 GLRSRTRACDQPPPQGLGDYCEGPR-AQGEVCQALPCP--VTNCTAIEGAEYSPCGPPCP 3327
Query: 647 RVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGP 686
R C + C+ G CPP L C+ P
Sbjct: 3328 RSCDDLVHCVWRCQPG-----CYCPPGQVLSSNGAICVQP 3362
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 33.1 bits (74), Expect = 0.98
Identities = 33/146 (22%), Positives = 53/146 (36%), Gaps = 30/146 (20%)
Query: 589 PQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLV-------------- 634
PQ + C R + Q YI G C+ CP +
Sbjct: 564 PQAMNITCTGRGPDNCIQCAH---YIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLC 620
Query: 635 ----TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMG--PTT 688
T GPG+ + A+ C +SC GS + P + Q SC+G P+
Sbjct: 621 HPNCTYGPGNESLKAMLFCLFKLSSCNQSNDGSVSHQSGSPAA------QESCLGWIPSL 674
Query: 689 PDSRPRLRAAACPH-HRCPASAMVLS 713
S +L C H H P+++++++
Sbjct: 675 LPSEFQLGWGGCSHLHAWPSASVIIT 700
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/53 (32%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 649 CSSCHASCY-TCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAAC 700
C CH SC C G + C + + +Q G C GP D R A C
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGC 238
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 32.3 bits (72), Expect = 1.7
Identities = 17/53 (32%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 649 CSSCHASCY-TCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAAC 700
C CH SC C G + C + + +Q G C GP D R A C
Sbjct: 186 CGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGC 238
>gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens]
Length = 333
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 6/54 (11%)
Query: 635 TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCP---PSSTLDQQQGSCMG 685
T GP + R CS H + C G RDC P P T D Q G C G
Sbjct: 233 TLGPAQCGSGRRRACSVLH---HHCDGIRFRDCHCAPSACPGPTQDPQAGLCTG 283
>gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo
sapiens]
Length = 333
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 6/54 (11%)
Query: 635 TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCP---PSSTLDQQQGSCMG 685
T GP + R CS H + C G RDC P P T D Q G C G
Sbjct: 233 TLGPAQCGSGRRRACSVLH---HHCDGIRFRDCHCAPSACPGPTQDPQAGLCTG 283
>gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo
sapiens]
Length = 333
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/54 (37%), Positives = 22/54 (40%), Gaps = 6/54 (11%)
Query: 635 TAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCP---PSSTLDQQQGSCMG 685
T GP + R CS H + C G RDC P P T D Q G C G
Sbjct: 233 TLGPAQCGSGRRRACSVLH---HHCDGIRFRDCHCAPSACPGPTQDPQAGLCTG 283
>gi|118582257 vesicular acetylcholine transporter [Homo sapiens]
Length = 532
Score = 32.0 bits (71), Expect = 2.2
Identities = 32/112 (28%), Positives = 44/112 (39%), Gaps = 17/112 (15%)
Query: 625 PRFFNHTRLVTAGPGHTAA---PALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQG 681
P + H R GP T P L + + +AS YT TS P++ G
Sbjct: 58 PDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTAN-------TSASPTAAWPA--G 108
Query: 682 SCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPL 733
S + P P ++ AS +L LL L GP + MS D+PL
Sbjct: 109 SALRPRYPTESEDVKIGVLF-----ASKAILQLLVNPLSGPFIDRMSYDVPL 155
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 32.0 bits (71), Expect = 2.2
Identities = 40/143 (27%), Positives = 47/143 (32%), Gaps = 29/143 (20%)
Query: 584 ARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAA 643
A P G + AC T +CQ DG A+ Q L +C N T G G T +
Sbjct: 102 AWPEGARWEPDAC----TACVCQ--DGAAHCGPQAHLPHCRGCSQNGQ---TYGNGETFS 152
Query: 644 PALRVCSSCHASCYTC------RGGSPRD---CTSCPPSSTLDQQ-----------QGSC 683
P C TC RG P C C P + Q C
Sbjct: 153 PDACTTCRCLEGTITCNQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPC 212
Query: 684 MGPTTPDSRPRLRAAACPHHRCP 706
+ T SR R A CP CP
Sbjct: 213 LQCTCLRSRVRCMALKCPPSPCP 235
>gi|4506143 neurotrypsin precursor [Homo sapiens]
Length = 875
Score = 32.0 bits (71), Expect = 2.2
Identities = 18/63 (28%), Positives = 28/63 (44%), Gaps = 5/63 (7%)
Query: 256 SASWGPE-DDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYT 314
+ WG DDG T ++ R+ +G + R T+ + G G +H DN C G
Sbjct: 518 NGQWGTICDDGWTDKDAAVICRQLGYKGPARAR----TMAYFGEGKGPIHVDNVKCTGNE 573
Query: 315 NSI 317
S+
Sbjct: 574 RSL 576
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,154,346
Number of Sequences: 37866
Number of extensions: 1643434
Number of successful extensions: 3788
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 3637
Number of HSP's gapped (non-prelim): 110
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.