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Search of human proteins with 75677353
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677353 AAA-ATPase TOB3 [Homo sapiens]
(648 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677353 AAA-ATPase TOB3 [Homo sapiens] 1293 0.0
gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens] 1046 0.0
gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens] 637 0.0
gi|169218287 PREDICTED: similar to belphegor [Homo sapiens] 506 e-143
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens] 74 4e-13
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens] 72 2e-12
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens] 69 1e-11
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens] 69 1e-11
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens] 68 2e-11
gi|148746195 trichohyalin [Homo sapiens] 68 2e-11
gi|6005942 valosin-containing protein [Homo sapiens] 68 3e-11
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens] 64 4e-10
gi|40806170 spastin isoform 2 [Homo sapiens] 64 6e-10
gi|11875211 spastin isoform 1 [Homo sapiens] 64 6e-10
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens] 64 6e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 63 7e-10
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens] 63 7e-10
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens] 63 1e-09
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens] 62 1e-09
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens] 62 1e-09
gi|157671927 spermatogenesis associated 5 [Homo sapiens] 62 2e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 61 3e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 61 3e-09
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 61 3e-09
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 61 3e-09
gi|31742536 fidgetin-like 1 [Homo sapiens] 61 3e-09
gi|112789543 fidgetin-like 1 [Homo sapiens] 61 3e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 4e-09
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens] 61 4e-09
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens] 61 4e-09
>gi|75677353 AAA-ATPase TOB3 [Homo sapiens]
Length = 648
Score = 1293 bits (3347), Expect = 0.0
Identities = 648/648 (100%), Positives = 648/648 (100%)
Query: 1 MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK
Sbjct: 1 MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
Query: 61 AARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLS 120
AARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLS
Sbjct: 61 AARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLS 120
Query: 121 EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMEL 180
EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMEL
Sbjct: 121 EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMEL 180
Query: 181 RHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAF 240
RHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAF
Sbjct: 181 RHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAF 240
Query: 241 VTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHP 300
VTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHP
Sbjct: 241 VTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHP 300
Query: 301 IQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTL 360
IQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTL
Sbjct: 301 IQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTL 360
Query: 361 FAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKR 420
FAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKR
Sbjct: 361 FAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKR 420
Query: 421 ATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEE 480
ATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEE
Sbjct: 421 ATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEE 480
Query: 481 RERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQAT 540
RERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQAT
Sbjct: 481 RERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQAT 540
Query: 541 AYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLAT 600
AYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLAT
Sbjct: 541 AYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLSGVQGETLTSWSLAT 600
Query: 601 DPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL 648
DPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL
Sbjct: 601 DPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGHPLL 648
>gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens]
Length = 634
Score = 1046 bits (2706), Expect = 0.0
Identities = 547/630 (86%), Positives = 562/630 (89%), Gaps = 48/630 (7%)
Query: 1 MSWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
MSWLFG+NKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK
Sbjct: 1 MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAK 60
Query: 61 AARELEHSRYAKEALNLAQMQEQTLQLEQQSKLK-------------------------- 94
AARELEHSRYAK+ALNLAQMQEQTLQLEQQSKLK
Sbjct: 61 AARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKMRLEALSLLHTLVWAWSLCRAGAVQT 120
Query: 95 ----------------------EYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 132
EYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY
Sbjct: 121 QERLSGSASPEQVPAGECCALQEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQY 180
Query: 133 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETE 192
QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVE E
Sbjct: 181 QDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAE 240
Query: 193 ARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVA 252
ARARAKAERENADI REQIRLKA+EHRQTVLESIRTAGTLFGEGFRAFVTD DKVTATVA
Sbjct: 241 ARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVA 300
Query: 253 GLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 312
GLTLLAVGVYSAKNAT V GRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ
Sbjct: 301 GLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQ 360
Query: 313 DVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGMD 372
D LEGVVLSPSLEARVRDIAIATRNTKKNR LYR+IL+YGPPGTGKTLFAKKLALHSGMD
Sbjct: 361 DALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMD 420
Query: 373 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKDLRAT 432
YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLF+DEADAFLRKRATE+IS+DLRAT
Sbjct: 421 YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRAT 480
Query: 433 LNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNC 492
LNAFLY GQHSNKFMLVLASN PEQFD AIN RI+ MVHFDLP QEERERLVR++FD
Sbjct: 481 LNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKY 540
Query: 493 VLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGVLTEA 552
VLKPATEGK+RLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYAS+DGVLTEA
Sbjct: 541 VLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEA 600
Query: 553 MMDACVQDAVQQYRQKMRWLKAEGPGRGVE 582
MMD VQDAVQQ++QKM WLKAEGPGRG E
Sbjct: 601 MMDTRVQDAVQQHQQKMCWLKAEGPGRGDE 630
>gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens]
Length = 411
Score = 637 bits (1643), Expect = 0.0
Identities = 349/458 (76%), Positives = 368/458 (80%), Gaps = 56/458 (12%)
Query: 130 AQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRV 189
AQ Q++ + E Q K +QL+NE+ LRKQEESVQK
Sbjct: 9 AQMQEQTLQ--LEQQSKLKQLVNED-LRKQEESVQK------------------------ 41
Query: 190 ETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTA 249
H QT LESIR AGTLFGEGFRAFVTDRDKVTA
Sbjct: 42 ----------------------------HHQTFLESIRAAGTLFGEGFRAFVTDRDKVTA 73
Query: 250 TVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPI-QVSRRLL 308
TVAGLTLLAVGVYSAKNATAVTGR+IEARLGKPSLVRETSRITVLEALRHPI QVSRRLL
Sbjct: 74 TVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEALRHPIQQVSRRLL 133
Query: 309 SRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALH 368
SRPQDVLEGVVLSPSLEARVRDIAI TRN KKNRGLYRHILLYGPPGTGKTLFAKKLALH
Sbjct: 134 SRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALH 193
Query: 369 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKD 428
SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLF+DEADAFLRKRATE+IS+D
Sbjct: 194 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 253
Query: 429 LRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLH 488
LRATLNAFLY GQHSNKFML+LAS PEQFD AIN+ IDVMVHFDLP QEER RLVR++
Sbjct: 254 LRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRMY 313
Query: 489 FDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGV 548
+ VLKPATEGKRRLKLAQFDYGRKC E+ARLTEGMS R+IAQLAVSWQATAYASKDGV
Sbjct: 314 LNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAVSWQATAYASKDGV 373
Query: 549 LTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLS 586
LTEAMMDACVQD VQQ++Q MRWLK E PG E P S
Sbjct: 374 LTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411
Score = 50.4 bits (119), Expect = 5e-06
Identities = 29/47 (61%), Positives = 34/47 (72%), Gaps = 7/47 (14%)
Query: 71 AKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRK 117
+K+ALNLAQMQEQTLQLEQQSKLK QL +E +R Q E +K
Sbjct: 2 SKDALNLAQMQEQTLQLEQQSKLK-------QLVNEDLRKQEESVQK 41
>gi|169218287 PREDICTED: similar to belphegor [Homo sapiens]
Length = 284
Score = 506 bits (1302), Expect = e-143
Identities = 243/243 (100%), Positives = 243/243 (100%)
Query: 406 LLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINS 465
LLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINS
Sbjct: 42 LLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINS 101
Query: 466 RIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGM 525
RIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGM
Sbjct: 102 RIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGM 161
Query: 526 SGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPL 585
SGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPL
Sbjct: 162 SGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPL 221
Query: 586 SGVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGH 645
SGVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGH
Sbjct: 222 SGVQGETLTSWSLATDPSYPCLAGPCTFRICSWMGTGLCPGPLSPRMSCGGGRPFCPPGH 281
Query: 646 PLL 648
PLL
Sbjct: 282 PLL 284
>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
Length = 403
Score = 73.9 bits (180), Expect = 4e-13
Identities = 87/371 (23%), Positives = 162/371 (43%), Gaps = 50/371 (13%)
Query: 207 IREQIR--LKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTATVAGLTLLAVGVYSA 264
+REQ++ K E + L+++++ G + GE + ++ V AT +
Sbjct: 43 LREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKAT------------NG 90
Query: 265 KNATAVTGRFIEARLGKPSLVRETSRITVLEALRH-PIQVSRRLLSRPQDVLEGVVLSP- 322
R ++ KP R +T L +R+ P +V + + + V S
Sbjct: 91 PRYVVGCRRQLDKSKLKPG-TRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEI 149
Query: 323 -SLEARVRDIAIATRNTKKNRGLYRHI--------LLYGPPGTGKTLFAKKLALHSGMDY 373
L ++R++ N L++ + LLYGPPGTGKTL A+ +A ++
Sbjct: 150 GGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNF 209
Query: 374 -AIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKD--LR 430
+++ V E + ++F++A + ++FMDE DA +R +E S D ++
Sbjct: 210 LKVVSSSIVDKYIGESARLIREMFNYAR-DHQPCIIFMDEIDAIGGRRFSEGTSADREIQ 268
Query: 431 ATLNAFLYHMGQHS--NKFMLVLASNLPEQFDCAI--NSRIDVMVHFDLPQQEERERLVR 486
TL L M ++ +++A+N P+ D A+ R+D +H DLP ++ R +++
Sbjct: 269 RTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILK 328
Query: 487 LHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAY-ASK 545
+H P T K + DY + +L++G +G ++ + A A
Sbjct: 329 IH-----AGPIT------KHGEIDY----EAIVKLSDGFNGADLRNVCTEAGMFAIRADH 373
Query: 546 DGVLTEAMMDA 556
D V+ E M A
Sbjct: 374 DFVVQEDFMKA 384
>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
Length = 795
Score = 71.6 bits (174), Expect = 2e-12
Identities = 67/209 (32%), Positives = 102/209 (48%), Gaps = 28/209 (13%)
Query: 349 LLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGLL 407
LL GPPG GKTL AK +A + + + M G + V +G G + LF A +R +
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEAR-ARAPCI 404
Query: 408 LFMDEADAFLRKRATEE---ISKDLRATLNAFLYHM-GQHSNKFMLVLAS-NLPEQFDCA 462
+++DE DA +KR+T + + TLN L M G + ++VLAS N + D A
Sbjct: 405 VYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGA 464
Query: 463 I--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFD--YGRKCSEV 518
+ R+D V DLP +ER + H + LKL Q Y ++ +
Sbjct: 465 LMRPGRLDRHVFIDLPTLQERREIFEQHL------------KSLKLTQSSTFYSQR---L 509
Query: 519 ARLTEGMSGREIAQLAVSWQATAYASKDG 547
A LT G SG +IA + +A +A+++G
Sbjct: 510 AELTPGFSGADIANICN--EAALHAAREG 536
>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
Length = 466
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/192 (27%), Positives = 96/192 (50%), Gaps = 16/192 (8%)
Query: 345 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 403
++ +LLYGPPGTGKTL AK +A + ++ + R + + LF+ A
Sbjct: 215 WKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHA 274
Query: 404 RGLLLFMDEADAFLRKRAT-----EEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQ 458
+F+DE ++ + +R T E S ++ L + + + + ++ ASNLP +
Sbjct: 275 PS-TIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWE 333
Query: 459 FDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEV 518
DCA+ R++ + DLP +E R+ ++ H+ L P ++ + + +Y S +
Sbjct: 334 LDCAMLRRLEKRILVDLPSREARQAMI-YHW----LPPVSKSRALELHTELEY----SVL 384
Query: 519 ARLTEGMSGREI 530
++ TEG SG +I
Sbjct: 385 SQETEGYSGSDI 396
>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
Length = 444
Score = 69.3 bits (168), Expect = 1e-11
Identities = 54/192 (28%), Positives = 92/192 (47%), Gaps = 21/192 (10%)
Query: 345 YRHILLYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWANTS 402
+R ILL+GPPGTGK+ AK +A + ++I + V+ E + LF A +
Sbjct: 167 WRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLAREN 226
Query: 403 RRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM---GQHSNKFMLVLASNLPEQF 459
+ ++F+DE D+ R+ E S+ R FL M G ++ +++ A+N+P
Sbjct: 227 KPS-IIFIDEIDSLCGSRSENE-SEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVL 284
Query: 460 DCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVA 519
D AI R + ++ LP+ R + +LH G + L + D+ E+
Sbjct: 285 DSAIRRRFEKRIYIPLPEPHARAAMFKLHL----------GTTQNSLTEADF----RELG 330
Query: 520 RLTEGMSGREIA 531
R T+G SG +I+
Sbjct: 331 RKTDGYSGADIS 342
>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
Length = 437
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 21/192 (10%)
Query: 345 YRHILLYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWANTS 402
+R ILL+GPPGTGK+ AK +A + +++ + ++ E + LF+ A
Sbjct: 160 WRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQH 219
Query: 403 RRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM---GQHSNKFMLVLASNLPEQF 459
+ ++ F+DE D+ R E S+ R FL M G +++ +++ A+N+P
Sbjct: 220 KPSII-FIDEVDSLCGSRNENE-SEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277
Query: 460 DCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVA 519
D AI R + ++ LP++ R ++ RLH G L E+A
Sbjct: 278 DSAIRRRFEKRIYIPLPEEAARAQMFRLHL----------GSTPHNLTD----ANIHELA 323
Query: 520 RLTEGMSGREIA 531
R TEG SG +I+
Sbjct: 324 RKTEGYSGADIS 335
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/194 (28%), Positives = 94/194 (48%), Gaps = 29/194 (14%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQ------------ 102
L+ + R+LE +E Q Q+Q L+ EQQ + K+ E EQ
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQ-QQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 103 ----LKSEQIRAQAEER-----RKTLSEETRQHQARAQYQDKLARQ--RYEDQL-KQQQL 150
+ +Q+R + EER R+ EE R+ Q R + +++ Q R E QL ++QQL
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 151 LNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQ 210
E+ LR++++ ++Q+ R + RE +LR + ++ R + E R K E+E REQ
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER----REQ 445
Query: 211 IRLKASEHRQTVLE 224
+ E R+ L+
Sbjct: 446 RLKREQEERRDWLK 459
Score = 66.6 bits (161), Expect = 7e-11
Identities = 49/161 (30%), Positives = 82/161 (50%), Gaps = 3/161 (1%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 122
REL R Q +E+ ++ Q+ + KE+ L+ E+ + Q EE ++ +
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 123 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLR-KQEESVQKQEAMRRATVE-REMEL 180
+ Q R + +L R+R E++ +QQ+L E+ LR KQEE ++Q+ RR E RE +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 181 RHKNEMLRVETEARARAKAERENADIIRE-QIRLKASEHRQ 220
+ + LR E E R + RE + RE Q+R + E R+
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Score = 65.1 bits (157), Expect = 2e-10
Identities = 44/156 (28%), Positives = 84/156 (53%), Gaps = 7/156 (4%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
ER + +E E + K L + +E+ LQ E+ + +E + EQL+ + + +E
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRK-EEEKLQEEEPQRQRELQEEEEQLR----KLERQEL 286
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVE 175
R+ EE +Q Q R + + +L R++ E++ +QQ+ E+ R++++ ++++ +RR E
Sbjct: 287 RRERQEEEQQQQ-RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 176 R-EMELRHKNEMLRVETEARARAKAERENADIIREQ 210
R E +LR + E R E + R + ER + REQ
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Score = 63.9 bits (154), Expect = 4e-10
Identities = 39/149 (26%), Positives = 81/149 (54%), Gaps = 1/149 (0%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLAR 138
+ +EQ L+ EQ+ + ++ E+ + Q R ++E++ + EE R+ + + + +L +
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 139 QRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAK 198
+R E +LK++Q + L K+EE ++Q+ ++R ER + + E+ R+E E R +
Sbjct: 561 ERREQRLKREQEERRDQLLKREEE-RRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 199 AERENADIIREQIRLKASEHRQTVLESIR 227
+RE + R Q LK+ E + + +R
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLR 648
Score = 60.5 bits (145), Expect = 5e-09
Identities = 49/187 (26%), Positives = 92/187 (49%), Gaps = 17/187 (9%)
Query: 57 RAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQ-IRAQAEER 115
R + R+ E R + + Q++ + + +Q +E E +EQ + EQ ++ + EER
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 116 RKTL---SEETRQHQARAQYQDKLAR-------QRYEDQLKQQQLLN----EENLRKQEE 161
R L EE RQ + + + +++L + +R E + +++Q L EE R+Q
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 162 SVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQT 221
++QE R+ + RE + R + + R E E R + +RE+ + REQ A E ++
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ--ELAEEEQEQ 692
Query: 222 VLESIRT 228
E I++
Sbjct: 693 ARERIKS 699
Score = 59.7 bits (143), Expect = 8e-09
Identities = 45/159 (28%), Positives = 84/159 (52%), Gaps = 13/159 (8%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQ-LEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
ER + R L ++ + +E+ LQ LE++ +L+ E A +QL+ E+ Q ++
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA-QQLQEEEDGLQEDQ 860
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRY--------EDQL-KQQQLL--NEENLRKQEESV 163
R+ E+ R + R Q +++ R+R+ ++QL K+QQLL EE L+++E
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 164 QKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERE 202
++++ R E E + + ++LR E E R R + ER+
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Score = 59.7 bits (143), Expect = 8e-09
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 24/184 (13%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E K R+ +Y +E L Q +EQ L+ E++ K + E + K ++++ + E+
Sbjct: 976 EEPEKRRRQEREKKYREEE-ELQQEEEQLLR-EEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLK------------QQQLLNEENLRKQEESV 163
+ E+ R + QY+++ Q+ E+QL ++Q EE L+++EE +
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 164 QKQEAMRRATVEREMELRHKNE-------MLRVETEARARAKAE---RENADIIREQIRL 213
++E +R ERE + R + E +LR E E R R + E RE ++ +E+ +L
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 214 KASE 217
E
Sbjct: 1154 LREE 1157
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/150 (30%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLAR 138
+ +E+ L+LE++ + ++ E +QL+ EQ + E+R K EE R Q R
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQ-EERREQRLKRQEEEERLQQ----------R 531
Query: 139 QRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAK 198
R E QL+++Q E L K+EE + ++ R ++RE E R + R E + R K
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 199 AERE---NADIIREQI-RLKASEHRQTVLE 224
E+E + RE++ RL+ E R+ L+
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLK 621
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 24/180 (13%)
Query: 55 LERAAKAARELEHSRYAKEALN--------LAQMQEQTLQLEQQSKLKEYEAAVEQLKSE 106
LE K R H+ YAK AL L Q +E+ LQ E++ K + E + + E
Sbjct: 878 LEEERKRRR---HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 107 QIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQL------KQQQLLNEENLRKQE 160
Q++ + E+ + E+ R+ + QY+ Q+ E+QL K+++ E+ R++E
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 161 ESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
E Q++E + R E E R + E E + R + + ++E ++RE+ + + R+
Sbjct: 995 ELQQEEEQLLR----EEREKRRRQEW---ERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/161 (27%), Positives = 87/161 (54%), Gaps = 14/161 (8%)
Query: 54 GLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEY-------EAAVEQLKSE 106
G ER + +ELE +Y KE L Q +EQ L+ E + + ++ E ++Q + +
Sbjct: 1065 GEERETRRRQELER-QYRKEE-ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 107 QIRAQAEERRK-TLSEETRQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEES 162
+R + E+RR+ L + R+ + Q +++L R+ E + +Q+ Q EE L+++EE
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 163 VQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAEREN 203
+ ++E +R ERE + R + E+ R + + R R + +R +
Sbjct: 1183 LLREEQEKRRQ-ERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Score = 58.2 bits (139), Expect = 2e-08
Identities = 47/173 (27%), Positives = 88/173 (50%), Gaps = 7/173 (4%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQ---EQTLQLEQQSKLKEYEAAVEQLKSEQIRAQ 111
L R + R+ E R ++ Q + +Q + EQQ + ++ E +QL+ EQ +
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 112 AEER-RKTLSEETRQHQARAQYQDKLARQ-RYEDQLK-QQQLLNEENLRKQEESVQKQEA 168
E++ R+ EE R+ Q R + Q + +Q R E QL+ +QQL E+ LR++++ ++Q+
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 169 MRRATVEREM-ELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
R + RE E RH+ + + E R + + E + RE+ + + R+
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Score = 57.8 bits (138), Expect = 3e-08
Identities = 47/202 (23%), Positives = 96/202 (47%), Gaps = 34/202 (16%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQ--LKSEQIRAQA 112
L R + RE + R +E + +EQ L+ EQ+ + +E + EQ + +Q+R +
Sbjct: 339 LRREQEERREQQLRREQEE-----ERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 113 EERRK---------------------TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLL 151
+ RR+ ++ R+ Q +++ K ++R E +LK++Q
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 152 NEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQ- 210
+ L+++EE+ + ++ R+ ++R+ E + L++E E R R + ER + REQ
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER-REQQERREQQLRREQE 512
Query: 211 ----IRLKASEHRQTVLESIRT 228
RLK E + + + +R+
Sbjct: 513 ERREQRLKRQEEEERLQQRLRS 534
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/181 (24%), Positives = 86/181 (47%), Gaps = 17/181 (9%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
L R + RE + R + +EQ L+ EQQ + ++ +QL+ EQ + E+
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 115 RRKTLSEETRQHQARAQYQDKLARQ----RYEDQLKQQQLLNEEN-------LRKQEESV 163
+ + E R + + + +D L R+ R+E + ++QQL ++ L+ +EE
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 164 QKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVL 223
++Q+ R + RE E R + + R E E R + + E +Q+R + E R+ +L
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE------QQLRREQEERREQLL 550
Query: 224 E 224
+
Sbjct: 551 K 551
Score = 57.0 bits (136), Expect = 5e-08
Identities = 52/198 (26%), Positives = 92/198 (46%), Gaps = 28/198 (14%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSK-LKEYEAAV---EQLKSEQIRA 110
L + R E R ++ L Q +EQ L+ E++ + L+E E E+L+ E+ +
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 111 QAEER----RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEESV 163
EER R+ L + R+ + Q +++L R+ E + +Q+ Q EE L+++EE +
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Query: 164 QKQEAMRRATVEREMELRHKNE-------MLRVETEARARAKAER----------ENADI 206
++E +R E E + R + E +LR E E R R + ER E +
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 207 IREQIRLKASEHRQTVLE 224
+RE+ + E + E
Sbjct: 1184 LREEQEKRRQERERQYRE 1201
Score = 57.0 bits (136), Expect = 5e-08
Identities = 45/173 (26%), Positives = 82/173 (47%), Gaps = 20/173 (11%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERR----KT 118
+ELE +E L QEQ + E+ K+ E E + + +Q+R Q +R+ +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 119 LSEETRQHQARAQYQDK-------LARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 171
L +E + Q R+Q D+ L ++R E QL+ QQ + R +EE +Q +E +R
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQR 1836
Query: 172 ATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLE 224
ER+ + R E + + K+ RE ++ +E+ + + E + + E
Sbjct: 1837 LRQERDRQ-------YRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Score = 56.6 bits (135), Expect = 7e-08
Identities = 49/178 (27%), Positives = 86/178 (48%), Gaps = 19/178 (10%)
Query: 60 KAARELEHSRYAKEALNLAQMQ-EQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKT 118
K R+ + ++ ++ L + + +Q L+ E+ K +E E +++ + +Q+ Q E RK
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ-ERDRKF 1645
Query: 119 LSEET---RQHQARAQYQDKLARQRYEDQLKQ----QQLLNEENLRK--QEESVQKQEAM 169
L EE RQ + + D+ + R E+QL Q QQL +E RK +EE +++
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705
Query: 170 RRATVEREMELR--------HKNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
R ++ E +LR + E LR ETE + ER + EQ+R + E +
Sbjct: 1706 ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Score = 56.2 bits (134), Expect = 9e-08
Identities = 51/179 (28%), Positives = 90/179 (50%), Gaps = 15/179 (8%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
L R + RE E R+ E + + +EQ L+ EQ+ + + E + EQ R + +
Sbjct: 419 LRREQQLRREQEEERH--EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 115 RRKTLSEETRQHQARAQYQDKLARQ-RYEDQL-KQQQLLNEENLRKQEES------VQKQ 166
+R EE R+ + + +++ +Q R E QL ++Q+ E+ L++QEE ++ +
Sbjct: 477 KRDQ-EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 167 EAMRRATVEREMELRHKNEMLRVETEAR-ARAKAERENADIIREQIRLKASEHRQTVLE 224
+ +RR ER +L + E R+E E R R K E+E R+Q+ + E RQ L+
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER---RDQLLKREEERRQQRLK 591
Score = 56.2 bits (134), Expect = 9e-08
Identities = 49/194 (25%), Positives = 96/194 (49%), Gaps = 21/194 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKE-------Y 96
KD+ + L + R E R +E L Q +EQ L E++++ ++
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 97 EAAVEQLKSEQIRAQAEERRKTLSE-ETRQHQARAQYQDKLARQRYEDQLKQQ---QLLN 152
E ++Q + + +R + E+RR+ E + R+ + Q +++L R+ E + +Q+ Q
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 153 EENLRKQEESV--QKQEAMRRATVER----EMELRHKNEMLRVETEARARAKAERENADI 206
EE ++++EE + ++ E RR +ER E EL+ + E L E + + R + ER+
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ---- 1198
Query: 207 IREQIRLKASEHRQ 220
RE+ L+ + +Q
Sbjct: 1199 YREEEELQRQKRKQ 1212
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/153 (27%), Positives = 77/153 (50%), Gaps = 5/153 (3%)
Query: 55 LERAAKAARELEHSRYAKEALN-LAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAE 113
LE+ + + L+ +E L + +EQ + +QQ + ++ E ++LK E+ + E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 114 ERRKTLSEETRQHQARAQYQDKLARQRYEDQLK--QQQLLNEENLRKQE--ESVQKQEAM 169
+R K EE R+ Q A+ + + AR+R + ++ Q QL +E + R+ + +KQE
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAERE 202
RR + E R ++E+ E E R + E E
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/186 (25%), Positives = 87/186 (46%), Gaps = 28/186 (15%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQ-----QSKLKEYEAAVE-QLKSEQIRAQAEERR 116
R E R +E L Q +EQ L+ E+ Q + ++Y + Q K EQ+ + E+R
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 117 KTLSEET--RQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEESVQKQEAMRR 171
+ E R+ + Q +++L R+ E + +Q+ Q ++ L+++EE + ++E +R
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 172 ATVEREMELRHKNE-------MLRVETEARARAKAER----------ENADIIREQIRLK 214
ERE + R + E +L E E R R + ER E ++RE+ +
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 215 ASEHRQ 220
+ R+
Sbjct: 1102 RRQERE 1107
Score = 54.7 bits (130), Expect = 3e-07
Identities = 49/179 (27%), Positives = 85/179 (47%), Gaps = 20/179 (11%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
ER K E + R + Q ++Q + E + K +E E ++ + EQ+R Q E
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ-ERY 1746
Query: 116 RKTLSEET-----RQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQE--ESVQKQEA 168
RK L EE + Q R Q +D+ R+ E+QL+Q++ E+ LR QE +++E
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFRE--EEQLRQER--EEQQLRSQESDRKFREEEQ 1802
Query: 169 MRRATVEREM-------ELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
+R+ E+++ + R + E L++E E R + ER+ EQ + R+
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLE-EQEQRLRQERDRQYRAEEQFATQEKSRRE 1860
Score = 53.9 bits (128), Expect = 4e-07
Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 16/153 (10%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARA----QYQD 134
Q +EQ L+ ++ K +E E +++ + +Q+R Q +R+ E+ + Q R Q +
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 135 KLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEAR 194
+L RQ E + ++++ L +E ++E +++QE R+ E E LR E E +
Sbjct: 1715 QLRRQELERKFREEEQLRQET---EQEQLRRQERYRKILEE---------EQLRPEREEQ 1762
Query: 195 ARAKAERENADIIREQIRLKASEHRQTVLESIR 227
+ ER+ EQ+R + E + ES R
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/179 (27%), Positives = 87/179 (48%), Gaps = 25/179 (13%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQ-IRAQAE 113
L R + RE + R ++ L Q + QL ++ + + +E EQ + EQ ++ + E
Sbjct: 395 LRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 114 ERRKTLS--EETRQHQARAQYQ------DKLARQRY----EDQLKQQQLLNEENLRKQEE 161
ERR L EET +H+ + Q ++ R+R+ E++ ++QQ E+ LR+++E
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512
Query: 162 SVQKQEAMRRATVER-------EMELRHKNEMLR---VETEARARAKAERENADIIREQ 210
++Q R+ ER E +LR + E R ++ E R + ER + REQ
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Score = 51.2 bits (121), Expect = 3e-06
Identities = 39/171 (22%), Positives = 89/171 (52%), Gaps = 10/171 (5%)
Query: 56 ERAAKAARE---LEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQA 112
ERA + E L+ + + + + Q+ QLE++ K + + + EQ+R +
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 113 EERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRA 172
+ ++ E R+ + + + Q++ + R E+QL+Q++ E+ LR++ E ++QE R+
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE---EQLLREEREKRRRQERERQY 960
Query: 173 TVEREMELRHKNEMLRVETEARARAKAE---RENADIIREQIRLKASEHRQ 220
+++++ + + ++L E E R R + E RE ++ +E+ +L E +
Sbjct: 961 RKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Score = 50.4 bits (119), Expect = 5e-06
Identities = 38/147 (25%), Positives = 71/147 (48%), Gaps = 6/147 (4%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQS--KLKEYEAAVEQLKSEQIRAQAE 113
ER + R E R +E L Q +E+ Q+S K +E E ++ + +Q+R Q
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 114 ERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRAT 173
+ + EE Q + + Q +L ++R ++Q +E R++E+ + ++E +R
Sbjct: 1818 DGKYRWEEEQLQLEEQEQ---RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 174 VEREMELRHKNEMLRVETEARARAKAE 200
ERE +LR ++ + + E R R E
Sbjct: 1875 -ERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 50.1 bits (118), Expect = 6e-06
Identities = 39/166 (23%), Positives = 80/166 (48%), Gaps = 10/166 (6%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
L + R E R +E L Q +EQ L+ E++ K + E + + E+++ + E+
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLR-EEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATV 174
+ E+ R+ + QY+++ Q+ E+QL L E+ R+QE Q +E
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQL----LREEQEKRRQERERQYREEEELQRQ 1208
Query: 175 EREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
+R+ R +++ ++ + + + E+ENA + ++ K E+ Q
Sbjct: 1209 KRKQRYRDEDQ----RSDLKWQWEPEKENA-VRDNKVYCKGRENEQ 1249
Score = 49.7 bits (117), Expect = 8e-06
Identities = 43/162 (26%), Positives = 77/162 (47%), Gaps = 9/162 (5%)
Query: 64 ELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEET 123
E E R +E + +EQ LQ ++ L+ E + + E++R Q E+ RK L EE
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD-RKFREEELRHQ-EQGRKFLEEEQ 1381
Query: 124 RQHQARAQYQDKLARQRYEDQLKQQQLLNEEN--LRKQEESVQKQEAMRRATVEREMELR 181
R + + + Q+ Q ++QQL + + R++E+ + +QE R+ E + R
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 182 HKNEMLRVETEARARAKAE---RENADIIREQIRLKASEHRQ 220
+ E +E E + R + RE +++E R + HRQ
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQE--REEQQLHRQ 1481
Score = 49.7 bits (117), Expect = 8e-06
Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 32/196 (16%)
Query: 55 LERAAKAARELEHSRYAKEALNL-AQMQEQTLQLEQQSKLKEYEAAVEQLK--------S 105
LE + R+ ++ KE L Q +EQ L+ ++ K +E E + + +
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 106 EQIRAQAEERRKTLSEETRQHQAR---AQYQDKLARQRYEDQL-----------KQQQLL 151
+Q+R Q E RK L EE + Q R + +++L ++R E QL ++QQL
Sbjct: 1437 QQVRRQ-ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 152 NEENLRKQEESVQKQEAMRRATVEREMEL---RHKNEMLRVETEARARAKAERENADIIR 208
+E RK E + + R +E E +L + + + L+ E + R + + ++ D R
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 209 -----EQIRLKASEHR 219
EQ+R + E +
Sbjct: 1556 KFREEEQLRQEREEQQ 1571
Score = 49.7 bits (117), Expect = 8e-06
Identities = 39/166 (23%), Positives = 87/166 (52%), Gaps = 18/166 (10%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQ--------LEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
R+ H ++ +E L + +EQ L LE++ +L+ E + + +++R+Q E
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD-RKFREQELRSQ-EP 1513
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATV 174
RK L EE + H R Q Q K ++ E QL++Q+ ++ + ++ +++E +R+
Sbjct: 1514 ERKFLEEEQQLH--RQQRQRKFLQE--EQQLRRQER-GQQRRQDRDRKFREEEQLRQERE 1568
Query: 175 EREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
E+++ + ++ R+E + R + ER+ + ++ +L+ E +Q
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERK---FMEDEQQLRRQEGQQ 1611
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/175 (26%), Positives = 84/175 (48%), Gaps = 14/175 (8%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQA--E 113
ER + R+ ++ + +E+ + EQ K +E E EQ+R + E
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE-EFPDEEQLRRRELLE 217
Query: 114 ERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRAT 173
RRK E+ +Q + R QD++ ++ E + ++++ + LRK+EE +Q++E R+
Sbjct: 218 LRRKGREEKQQQRRER---QDRVFQEEEEKEWRKRETV----LRKEEEKLQEEEPQRQRE 270
Query: 174 VEREMELRHKNEMLRVETEARARAKAERENADIIRE-QIRLKASEHRQTVLESIR 227
++ E E K E + R R + E++ + RE Q+R K E R+ E R
Sbjct: 271 LQEEEEQLRKLERQELR---RERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/197 (21%), Positives = 89/197 (45%), Gaps = 15/197 (7%)
Query: 33 GDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSK 92
G++ DR + +W D E + E E + AK +Q ++Q L+ E++ K
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPE---EEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 93 LKEYEAAVEQLKSEQIRAQAEE---RRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQ 149
+ E + + EQ+ + EE RR+ + R+ + R Q Q + + E +L++Q+
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQE 1387
Query: 150 LLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEML------RVETEARARAKAEREN 203
E K+E+ ++ QE ++ +R+ + R + + L R E + + +
Sbjct: 1388 --RERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 204 ADIIREQIRLKASEHRQ 220
+ E+ +L+ HR+
Sbjct: 1446 RKFLEEEQQLRQERHRK 1462
Score = 48.5 bits (114), Expect = 2e-05
Identities = 50/182 (27%), Positives = 93/182 (51%), Gaps = 20/182 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQ--EQTLQLEQQSKLKEYEAAVEQ---LKSEQIRA 110
ER + R + ++ L Q + EQ L+ EQ+ + +E + EQ + +Q+R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 111 QAEERRKTLSEETRQHQARAQYQDKLARQ-RYEDQLK-QQQLLNEENLRK-QEES----- 162
+ + RR+ + R+ Q R + Q + +Q R E QL+ +QQL E+ LR+ QEE
Sbjct: 380 EQQLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 163 ---VQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQ-IRLKASEH 218
++++ ++R ER L+ + E R E E R + + +R+ + RE+ ++L+ E
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQE-RRKQQLKRDQEEERRERWLKLEEEER 496
Query: 219 RQ 220
R+
Sbjct: 497 RE 498
Score = 47.4 bits (111), Expect = 4e-05
Identities = 48/176 (27%), Positives = 86/176 (48%), Gaps = 24/176 (13%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
L R + + LE + + + +EQ L+ ++ + + L+ EQ + +
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER--------KFLEEEQQLHRQQR 1529
Query: 115 RRKTLSEE---TRQHQARAQYQDKLARQRYEDQLKQ----QQLLNEENLRK---QEESVQ 164
+RK L EE RQ + + + QD+ + R E+QL+Q QQL +E RK +E+ V+
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 165 KQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
+QE R +E E +LR + ++ E R + RE+ +++E R + HRQ
Sbjct: 1590 RQE-QERKFMEDEQQLRRQEGQQQLRQE---RDRKFREDEQLLQE--REEQQLHRQ 1639
Score = 47.0 bits (110), Expect = 5e-05
Identities = 43/182 (23%), Positives = 82/182 (45%), Gaps = 18/182 (9%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQ-IRAQAEE 114
ER + R E R +E L ++ LE++ +L+ E + LK EQ +R Q E
Sbjct: 1347 EREEQPLRRQERDRKFREE-ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 115 RR-------------KTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRK--- 158
++ + LS + R + R + Q ++R L+++Q L +E RK
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 159 QEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEH 218
+E+ +Q++E + ER+ + + + LR + R + E + + R+ + + H
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 219 RQ 220
RQ
Sbjct: 1526 RQ 1527
Score = 46.2 bits (108), Expect = 9e-05
Identities = 42/145 (28%), Positives = 70/145 (48%), Gaps = 20/145 (13%)
Query: 81 QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQR 140
++Q + E+Q ++ + E E K E + + EE+ L EE Q Q Q +
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK---LQEEEPQRQRELQEE------- 274
Query: 141 YEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAE 200
E+QL++ L +E R+++E Q+Q+ +R RE +LR K E R E + R + E
Sbjct: 275 -EEQLRK--LERQELRRERQEEEQQQQRLR-----REQQLRRKQEEERREQQEERREQQE 326
Query: 201 RENADIIR--EQIRLKASEHRQTVL 223
R R +Q+R + E R+ L
Sbjct: 327 RREQQEERREQQLRREQEERREQQL 351
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/181 (21%), Positives = 89/181 (49%), Gaps = 24/181 (13%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
LE + R+ ++ ++ L + + + L+ EQQ +Q + + ++ + +
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR-------QQRQRKFLQEEQQL 1540
Query: 115 RRKTLSEETRQHQARA-QYQDKLARQRYEDQLKQQQ-----LLNEENLRKQ--------- 159
RR+ ++ RQ + R + +++L ++R E QL +Q+ L E+ +R+Q
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 160 EESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
E+ +++QE ++ ER+ + R ++L+ E E + + ER+ + E+ +L+ E
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQ-EREEQQLHRQERDR-KFLEEEPQLRRQERE 1658
Query: 220 Q 220
Q
Sbjct: 1659 Q 1659
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/181 (23%), Positives = 86/181 (47%), Gaps = 15/181 (8%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQE-QTLQLEQQSKLKEYEAAVEQLKSEQIRAQAE 113
LE + R+ ++ +E L + + Q + ++ K +E E ++ + +Q+ Q
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 114 ERRKTLSEET--RQHQARAQYQDK--LARQRYEDQLKQQQ----LLNEENLRKQEESVQK 165
+R+ L E+ RQ Q R +D+ L RQ + QL+Q++ +E+ L+++EE
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 166 QEAMRRATVEREMELR--HKNEMLRVETEARARAK----AERENADIIREQIRLKASEHR 219
++ R +E E +LR + + LR + + + R + E E + R++ K E
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 220 Q 220
Q
Sbjct: 1698 Q 1698
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/164 (25%), Positives = 85/164 (51%), Gaps = 14/164 (8%)
Query: 63 RELEHS----RYAKEALN--LAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERR 116
R+LE S R +++ L L + QE+ + E++ + E+ + E+ + +RR
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 117 KTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVER 176
S+E +Q R + ++K RQ + + ++++ L +E ++E+ +++QE R+ R
Sbjct: 1311 DRKSQEEKQ-LLREEREEKRRRQETDRKFREEEQLLQE---REEQPLRRQERDRKF---R 1363
Query: 177 EMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
E ELRH+ + + E + + ERE ++E+ +L+ E Q
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERER-KFLKEEQQLRCQEREQ 1406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/185 (23%), Positives = 92/185 (49%), Gaps = 19/185 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + +R+ ++ +E + + + + LE++ +L++ E + + EQ+ + EE+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ-ERHRKFREEEQLLQEREEQ 1476
Query: 116 --------RKTLSEE---TRQHQARAQYQDKLARQRYEDQL--KQQQLLNEENLRK---Q 159
RK L EE RQ + R + +L Q E + ++QQL ++ RK +
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 160 EESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
E+ +++QE ++ +R+ + R + E LR E E + ++ ER+ + EQ +++ E
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFR-EEEQLRQEREEQQLSRQERDRKFRLEEQ-KVRRQEQE 1594
Query: 220 QTVLE 224
+ +E
Sbjct: 1595 RKFME 1599
Score = 43.9 bits (102), Expect = 5e-04
Identities = 41/173 (23%), Positives = 82/173 (47%), Gaps = 14/173 (8%)
Query: 53 TGLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQA 112
TGL+ +A + KE+L + QE E Q + + + +E+ ++ R +
Sbjct: 93 TGLDEEKRARCD------GKESLLQDRRQE-----EDQRRFEPRDRQLEEEPGQRRRQKR 141
Query: 113 EERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNE-ENLRKQEESVQKQEAMRR 171
+E+ + L+E Q + + + + + ++R E+ +Q+Q E E R +EE +Q +
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 172 ATVEREMELRHKNEMLRVETEAR-ARAKAERENADIIREQIRLKASEHRQTVL 223
E +LR + E+L + + R + + RE D + ++ K R+TVL
Sbjct: 202 EEFPDEEQLR-RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Score = 43.1 bits (100), Expect = 8e-04
Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 27/179 (15%)
Query: 63 RELEHSRYAKEALNLA-QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSE 121
RE E R +E L+ Q +++ +LE+Q K++ E + ++ EQ + RR+ +
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQ-KVRRQEQERKFMEDEQ-----QLRRQEGQQ 1611
Query: 122 ETRQHQARAQYQDK-LARQRYEDQLKQQQ-----LLNEENLRKQEESVQ----------K 165
+ RQ + R +D+ L ++R E QL +Q+ L E LR+QE Q +
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 166 QEAMRRATVEREMELRHKNEMLRVETEARARAKAER----ENADIIREQIRLKASEHRQ 220
+E + + E+++ + ++ R E + R + ER E + R+++ K E Q
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/158 (26%), Positives = 73/158 (46%), Gaps = 20/158 (12%)
Query: 77 LAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLS----EETRQHQARAQY 132
L + +E+ L+ E++ + +E E+ + EQ R Q ER K L EE Q + RAQ
Sbjct: 790 LREQRERQLRAEERQQ-REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 133 --------QDKLARQRYEDQLKQQQL---LNEENLRKQEESVQKQEAMRRATVEREMELR 181
Q+ R+R ++Q + Q+ L EE R++ K + E+++
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 182 HKNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
+ E+ R E E R + E+E RE+ +L+ E +
Sbjct: 909 EEEELQREEREKRR--RQEQERQ--YREEEQLQQEEEQ 942
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/162 (24%), Positives = 79/162 (48%), Gaps = 24/162 (14%)
Query: 79 QMQEQTLQLEQQSKLKEYE--AAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL 136
Q++E+ Q +Q + ++ A E+ +Q R + +R++ E RQ Q ++Q++
Sbjct: 128 QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQ---EWQERE 184
Query: 137 ARQRYEDQLKQ------QQLLNEENLRKQE---------ESVQKQEAMRRATV---EREM 178
R+ E+QL+ ++ +EE LR++E E Q+Q R+ V E E
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK 244
Query: 179 ELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQ 220
E R + +LR E E + +R+ ++ E+ +L+ E ++
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQR-ELQEEEEQLRKLERQE 285
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/181 (22%), Positives = 82/181 (45%), Gaps = 22/181 (12%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVE--------QLKSEQIRAQAEE 114
RE E R +E LA+ +++ + +S++ +++ +E ++ S + + +
Sbjct: 674 REHEEERREQE---LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730
Query: 115 RRKTLSEETRQHQARAQYQD--KLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRA 172
RR+ E+ R+ ++ Q+Q+ + RQ+ E++ ++ + K E Q+ A
Sbjct: 731 RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 173 TVEREMELRHKNEMLRV--------ETEARARAKAERE-NADIIREQIRLKASEHRQTVL 223
+RE +LR + R E E R R + ERE + E+ +L+ E Q +
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 224 E 224
E
Sbjct: 851 E 851
Score = 33.1 bits (74), Expect = 0.82
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 15/114 (13%)
Query: 63 RELEHSRYAKEALNLAQMQ--------EQTLQLEQQS-KLKEYEAAVEQLKSEQIRAQAE 113
RE E R +E L Q E+ LQLE+Q +L++ E + EQ Q +
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ-ERDRQYRAEEQFATQEK 1856
Query: 114 ERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQE 167
RR+ + Q R Q +++ R E+ +++QQ EE +Q ++ QE
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLR---EEHIRRQQ--KEEQRHRQVGEIKSQE 1905
>gi|6005942 valosin-containing protein [Homo sapiens]
Length = 806
Score = 67.8 bits (164), Expect = 3e-11
Identities = 62/233 (26%), Positives = 107/233 (45%), Gaps = 24/233 (10%)
Query: 346 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRR 404
R ILLYGPPGTGKTL A+ +A +G + ++ G ++ + + E + + K F+ A +
Sbjct: 239 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAP 298
Query: 405 GLLLFMDEADAFLRKRATE--EISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCA 462
++F+DE DA KR E+ + + + L + + Q ++ +++ A+N P D A
Sbjct: 299 A-IIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPA 356
Query: 463 IN--SRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVAR 520
+ R D V +P R ++++H N +KLA +VA
Sbjct: 357 LRRFGRFDREVDIGIPDATGRLEILQIHTKN------------MKLAD---DVDLEQVAN 401
Query: 521 LTEGMSGREIAQLAVSWQATAYASKDGV--LTEAMMDACVQDAVQQYRQKMRW 571
T G G ++A L A K + L + +DA V +++ RW
Sbjct: 402 ETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRW 454
Score = 53.9 bits (128), Expect = 4e-07
Identities = 48/193 (24%), Positives = 85/193 (44%), Gaps = 23/193 (11%)
Query: 348 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGL 406
+L YGPPG GKTL AK +A ++ + G ++ M E + ++FD A +
Sbjct: 514 VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQA-APC 572
Query: 407 LLFMDEADAFLRKRATE--EISKDLRATLNAFLYHMGQHSNK--FMLVLASNLPEQFDCA 462
+LF DE D+ + R + +N L M S K ++ A+N P+ D A
Sbjct: 573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPA 632
Query: 463 I--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVAR 520
I R+D +++ LP ++ R ++ K L+ + +A+
Sbjct: 633 ILRPGRLDQLIYIPLPDEKSRVAIL---------------KANLRKSPVAKDVDLEFLAK 677
Query: 521 LTEGMSGREIAQL 533
+T G SG ++ ++
Sbjct: 678 MTNGFSGADLTEI 690
>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
Length = 406
Score = 63.9 bits (154), Expect = 4e-10
Identities = 58/235 (24%), Positives = 103/235 (43%), Gaps = 27/235 (11%)
Query: 348 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGL 406
+LLYGPPGTGKTL A+ +A H+ + ++G + V EG + +LF A
Sbjct: 186 VLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAR-EHAPS 244
Query: 407 LLFMDEADAFLRKR------ATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFD 460
++FMDE D+ R E+ + + LN + + +++A+N + D
Sbjct: 245 IIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQL--DGFEATKNIKVIMATNRIDILD 302
Query: 461 CAI--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEV 518
A+ RID + F P +E R ++++H R++ L + G ++
Sbjct: 303 SALLRPGRIDRKIEFPPPNEEARLDILKIH------------SRKMNLTR---GINLRKI 347
Query: 519 ARLTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLK 573
A L G SG E+ + A + +T+ + V +Q+ +K +K
Sbjct: 348 AELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIK 402
>gi|40806170 spastin isoform 2 [Homo sapiens]
Length = 584
Score = 63.5 bits (153), Expect = 6e-10
Identities = 53/193 (27%), Positives = 94/193 (48%), Gaps = 19/193 (9%)
Query: 346 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRR 404
R +LL+GPPG GKT+ AK +A S + ++ + + EG + LF A +
Sbjct: 344 RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 403
Query: 405 GLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHS---NKFMLVLASNLPEQFDC 461
++F+DE D+ L +R E R + G S ++ +++ A+N P++ D
Sbjct: 404 S-IIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDE 462
Query: 462 AINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARL 521
A+ R V+ LP +E R L++ N + K + L Q ++ +++AR+
Sbjct: 463 AVLRRFIKRVYVSLPNEETRLLLLK----NLLCKQGS------PLTQ----KELAQLARM 508
Query: 522 TEGMSGREIAQLA 534
T+G SG ++ LA
Sbjct: 509 TDGYSGSDLTALA 521
>gi|11875211 spastin isoform 1 [Homo sapiens]
Length = 616
Score = 63.5 bits (153), Expect = 6e-10
Identities = 53/193 (27%), Positives = 94/193 (48%), Gaps = 19/193 (9%)
Query: 346 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRR 404
R +LL+GPPG GKT+ AK +A S + ++ + + EG + LF A +
Sbjct: 376 RGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 435
Query: 405 GLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHS---NKFMLVLASNLPEQFDC 461
++F+DE D+ L +R E R + G S ++ +++ A+N P++ D
Sbjct: 436 S-IIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDE 494
Query: 462 AINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARL 521
A+ R V+ LP +E R L++ N + K + L Q ++ +++AR+
Sbjct: 495 AVLRRFIKRVYVSLPNEETRLLLLK----NLLCKQGS------PLTQ----KELAQLARM 540
Query: 522 TEGMSGREIAQLA 534
T+G SG ++ LA
Sbjct: 541 TDGYSGSDLTALA 553
>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
Length = 439
Score = 63.5 bits (153), Expect = 6e-10
Identities = 50/214 (23%), Positives = 100/214 (46%), Gaps = 17/214 (7%)
Query: 312 QDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGM 371
Q+++E +VL + + + ++ I + +L+YGPPGTGKTL A+ A +
Sbjct: 196 QELVEAIVLPMNHKEKFENLGIQPP---------KGVLMYGPPGTGKTLLARACAAQTKA 246
Query: 372 DYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEIS--KD 428
+ + G + M +G + F A + ++F+DE DA KR E + ++
Sbjct: 247 TFLKLAGPQLVQMFIGDGAKLVRDAFALAK-EKAPSIIFIDELDAIGTKRFDSEKAGDRE 305
Query: 429 LRATLNAFLYHMG--QHSNKFMLVLASNLPEQFDCAI--NSRIDVMVHFDLPQQEERERL 484
++ T+ L + Q + + ++ A+N + D A+ + R+D + F +P +E R R+
Sbjct: 306 VQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARI 365
Query: 485 VRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEV 518
+++H + P + + G +C V
Sbjct: 366 MQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAV 399
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 63.2 bits (152), Expect = 7e-10
Identities = 40/155 (25%), Positives = 80/155 (51%), Gaps = 5/155 (3%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E+ + R E + +E + + QE+ +Q EQ+ K++E E E++ ++ + Q +E
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQ-EQEEKMQEQE---EKMWEQEEKMQEQEE 638
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVE 175
+ EE Q ++ + ++ E + +++ +E +++QEE + +QE M + T E
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 176 REMELRHKNEMLRVETEARARAKAERENADIIREQ 210
+E + E +R E R R K RE +++REQ
Sbjct: 699 QEKK-TWDQEKMREEESMREREKKMREEEEMMREQ 732
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/173 (26%), Positives = 88/173 (50%), Gaps = 22/173 (12%)
Query: 57 RAAKAARELEHSRYAKEALNLA---------QMQEQTLQLEQQSKLKEYEAAVEQLKSEQ 107
R KA R +E ++AL+L +++++ +L+++ L E E + QL ++
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 108 IRAQAEERR--------KTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEEN--LR 157
++ + E + TL EE + + + Q+K R++ E +Q++ L E+ +R
Sbjct: 251 LKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMR 310
Query: 158 KQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQ 210
+QEE + +QE R E+E ELR + + LR + E R + + +E + + EQ
Sbjct: 311 EQEEKMWRQEKRLR---EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
Score = 57.0 bits (136), Expect = 5e-08
Identities = 37/143 (25%), Positives = 75/143 (52%), Gaps = 13/143 (9%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLAR 138
+++EQ +L +Q +L+E E +++ E+ + EE+ + E+ + + R Q+K R
Sbjct: 329 ELREQEKELREQKELREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 139 QRYEDQLKQQQLL--NEENLRKQEESVQKQEAM---------RRATVEREMELRHKNEML 187
++ + Q++ + +E LR++EE +++QE M + E+E + R + E +
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 188 RVETEARARAKAERENADIIREQ 210
+ E R R K RE + +REQ
Sbjct: 447 QEEERIREREKKMREEEETMREQ 469
Score = 56.6 bits (135), Expect = 7e-08
Identities = 53/165 (32%), Positives = 81/165 (49%), Gaps = 20/165 (12%)
Query: 56 ERAAKAARELEHSRYAKEAL-----NLAQMQEQTLQL----EQQSKLKEYEAAVEQLKSE 106
ER K E E R +E + N+ + +E+ Q EQ+ KL E E EQ E
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ--EE 511
Query: 107 QIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESV-QK 165
+I Q E+ R EE + + Q+K+ Q EDQ+ +Q EE +R QE+ + +
Sbjct: 512 KIWEQEEKIRD--QEEMWGQEKKMWRQEKMREQ--EDQMWEQ----EEKMRDQEQKMWDQ 563
Query: 166 QEAMRRATVEREMELRHKNEMLRVETEARARAKAERENADIIREQ 210
+E M + T E+E + + E +R E R R K RE +++REQ
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Score = 54.3 bits (129), Expect = 3e-07
Identities = 46/153 (30%), Positives = 81/153 (52%), Gaps = 15/153 (9%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLE---QQSKLKEYEAAVEQLKSEQIRAQAEERRKTL 119
R+LE +++ L Q+Q TLQ E Q+ +L+E E + K E+ + EER +
Sbjct: 253 RKLERAKFL-----LPQVQTNTLQEEMWRQEEELREQEKKIR--KQEEKMWRQEERLREQ 305
Query: 120 SEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEE-NLRKQEESVQKQEAMRRATVEREM 178
+ R+ + + Q+K R++ ++ +Q++ L E+ LR+QEE +Q+QE E+E
Sbjct: 306 EGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQE---EKMWEQEE 362
Query: 179 ELRHKNE-MLRVETEARARAKAERENADIIREQ 210
++R + E M R E + K RE +R+Q
Sbjct: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
Score = 50.1 bits (118), Expect = 6e-06
Identities = 38/157 (24%), Positives = 80/157 (50%), Gaps = 11/157 (7%)
Query: 81 QEQTLQLEQQSKLKEYEAAV----EQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKL 136
QE+ L+ EQ+ K++E E + ++L+ ++ + +E+ +E R+ + + Q Q++
Sbjct: 298 QEERLR-EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Query: 137 ARQRYEDQLKQQQLL--NEENLRKQEESVQKQEAMRRATVEREME----LRHKNEMLRVE 190
++ E +Q++ + EE L +QE+ +++QE R ER E LR K E +R +
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 191 TEARARAKAERENADIIREQIRLKASEHRQTVLESIR 227
+ + + RE + ++ + + E + E IR
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453
Score = 46.2 bits (108), Expect = 9e-05
Identities = 33/159 (20%), Positives = 80/159 (50%), Gaps = 8/159 (5%)
Query: 63 RELEHSRYAKEAL--NLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLS 120
RE E +E + + +M+E+ EQ+ K ++ E E+++ E+ + E++ +
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE---EKMQEEERIREREKKMREEE 463
Query: 121 EETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMEL 180
E R+ + + Q Q++ ++ E + +QQ+L ++ ++E +Q+QE E+E ++
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE---EKIWEQEEKI 520
Query: 181 RHKNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
R + EM E + + K + + ++ +++ E +
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLK----SEQIRAQAEERRKTLSEETRQHQARAQYQD 134
+M EQ EQ+ KL E+E EQ K E+I Q + +KT +E + ++
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712
Query: 135 KLARQRYEDQLKQQQLLNE--ENLRKQEESVQKQEAMRRATVEREMELRHK 183
+ R+R + ++++++ E E +++QEE +Q+QE E+ E K
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763
Score = 43.1 bits (100), Expect = 8e-04
Identities = 33/153 (21%), Positives = 75/153 (49%), Gaps = 9/153 (5%)
Query: 79 QMQEQTLQL-EQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLA 137
+M+EQ Q+ EQ+ K+++ E + + + E+ +KT +E + + + +++
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREK 596
Query: 138 RQRYEDQLKQQQLLNEENLRKQEESVQKQE----AMRRATVEREMELRHKNEMLRVETEA 193
+ R E+++ ++Q EE +++QEE +Q+QE E+E ++ + E + + E
Sbjct: 597 KMREEEEMMREQ---EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653
Query: 194 RARAKAERENADIIREQIRLKASEHRQTVLESI 226
+ E + + E +++ E Q E I
Sbjct: 654 MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/114 (24%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLAR 138
+MQEQ EQ+ K+++ E E+++ ++ + + +E + EE Q + +
Sbjct: 782 KMQEQEKIWEQEEKMRDQE---EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 139 QRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETE 192
E+++ Q+ EE ++ QEE +++QE R +E ++R + E +R + E
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG---QEEKMREQEEKMRGQEE 889
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/181 (21%), Positives = 89/181 (49%), Gaps = 21/181 (11%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQL-EQQSKLKEYEAAV----EQLKSEQIRAQAEERRK 117
RE E + +E ++ EQ Q+ EQ+ K+++ E + E+L+ ++ R + +E+
Sbjct: 365 REQEEKMWRQEE----RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
Query: 118 TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN-EENLRKQEESVQKQEAMRRATVE- 175
E+ R+ + + Q Q+K R + E +++++ E+ +R++EE++++QE + E
Sbjct: 421 EQVEKMREEK-KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 176 ---------REMELRHKNEMLRVETEARARAKAERENADIIREQIRLKASEHRQTVLESI 226
++ L + E L + + + + + E + IR+Q + E + E +
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 227 R 227
R
Sbjct: 540 R 540
Score = 40.8 bits (94), Expect = 0.004
Identities = 33/143 (23%), Positives = 73/143 (51%), Gaps = 10/143 (6%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKS----EQIRAQAEERRKT 118
+E E + +E + + QEQ + Q K++E E+ E+ K E++ + EE+ +
Sbjct: 680 QEQEEKIWEQEKME-KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738
Query: 119 LSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREM 178
E+ ++ + Q++ ++ E +QQ+L ++ + E +Q+QE + E+E
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI----WEQEE 794
Query: 179 ELRHKNEMLRVETEARARAKAER 201
++R + E +R + E + R + E+
Sbjct: 795 KMRDQEEKMRGQ-EEKMRGQEEK 816
Score = 38.5 bits (88), Expect = 0.019
Identities = 34/155 (21%), Positives = 72/155 (46%), Gaps = 13/155 (8%)
Query: 79 QMQEQTLQL-EQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEET-RQHQARAQYQDKL 136
QM EQ ++ +Q+ K+ + E +E+ EQ + ++ K EE R+ + + + ++++
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 137 ARQRYEDQLKQQQLLNE---------ENLRKQEESVQKQEAMRRATVEREMELRHKNEML 187
R++ E +Q++ + E E +++QEE + +QE E+ E + E
Sbjct: 605 MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK 664
Query: 188 RV--ETEARARAKAERENADIIREQIRLKASEHRQ 220
E E + +E + I EQ +++ Q
Sbjct: 665 EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Score = 37.4 bits (85), Expect = 0.043
Identities = 32/144 (22%), Positives = 73/144 (50%), Gaps = 12/144 (8%)
Query: 79 QMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLAR 138
+M Q EQ+ ++ E E E+++ ++ + +E R + ++T++ + + Q++ R
Sbjct: 532 KMWRQEKMREQEDQMWEQE---EKMRDQEQKMWDQEER--MEKKTQEQEKKTWDQEEKMR 586
Query: 139 QRYEDQLKQQQLLNEEN-LRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARARA 197
+ + +++++ EE +R+QEE +Q+QE + E+ E K + E E +
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ----EQEEKMWE 642
Query: 198 KAER--ENADIIREQIRLKASEHR 219
+ E+ E + + EQ RL + +
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEK 666
Score = 37.4 bits (85), Expect = 0.043
Identities = 28/106 (26%), Positives = 55/106 (51%), Gaps = 5/106 (4%)
Query: 66 EHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAV---EQLKSEQIRAQAEERRKTLSEE 122
E + +E + + QE+ +Q EQ+ K++E E + E+ EQ E++R +E
Sbjct: 717 EREKKMREEEEMMREQEEKMQ-EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 123 TRQHQARAQYQDKLARQRYEDQLKQQQLLN-EENLRKQEESVQKQE 167
+ Q Q+K+ Q + + +++++ EE +R QEE ++ QE
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821
>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
Length = 361
Score = 63.2 bits (152), Expect = 7e-10
Identities = 55/194 (28%), Positives = 86/194 (44%), Gaps = 28/194 (14%)
Query: 348 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGL 406
+LLYGPPG GKTL AK A +G + + + E +F A +
Sbjct: 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA-IKLQPS 187
Query: 407 LLFMDEADAFLRKRATEEISKDLRATLNAFLYHMG-------QHSNKFMLVLASNLPEQF 459
++F+DE D+FLR R+ S D AT M HS + +++ A+N P+
Sbjct: 188 IIFIDEIDSFLRNRS----SSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDL 243
Query: 460 DCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVA 519
D AI R+ H + P ++RE +++L LK D EVA
Sbjct: 244 DSAIMRRMPTRFHINQPALKQREAILKL---------------ILKNENVDRHVDLLEVA 288
Query: 520 RLTEGMSGREIAQL 533
+ T+G SG ++ ++
Sbjct: 289 QETDGFSGSDLKEM 302
>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
Length = 433
Score = 62.8 bits (151), Expect = 1e-09
Identities = 57/225 (25%), Positives = 98/225 (43%), Gaps = 23/225 (10%)
Query: 348 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGL 406
+LL+GPPGTGKTL A+ +A + + + G + V EG + +LF+ A T ++
Sbjct: 212 VLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMART-KKAC 270
Query: 407 LLFMDEADAFLRKRATEEISKD--LRATLNAFLYHMG--QHSNKFMLVLASNLPEQFDCA 462
L+F DE DA R + D ++ T+ + + +++A+N P+ D A
Sbjct: 271 LIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPA 330
Query: 463 I--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVAR 520
+ R+D + F LP E R + ++H + E R +L +AR
Sbjct: 331 LMRPGRLDRKIEFSLPDLEGRTHIFKIH----ARSMSVERDIRFEL-----------LAR 375
Query: 521 LTEGMSGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQY 565
L +G EI + A ++ + TE V ++ Y
Sbjct: 376 LCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY 420
>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
Length = 773
Score = 62.4 bits (150), Expect = 1e-09
Identities = 61/209 (29%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 344 LYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 402
L + ILL GPPGTGKTL A+ +A + + + +G + M G + + LF A +
Sbjct: 371 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 429
Query: 403 RRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM-GQHSNKFMLVL-ASNLPEQFD 460
++F+DE D+ KR + R T+N L M G N+ ++++ A+N PE D
Sbjct: 430 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 489
Query: 461 CAI--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEV 518
A+ R D+ V P + R +++ + L +FD +
Sbjct: 490 NALIRPGRFDMQVTVPRPDVKGRTEILKWY---------------LNKIKFDQSVDPEII 534
Query: 519 ARLTEGMSGREIAQLAVSWQATAYASKDG 547
AR T G SG E+ L QA A+ DG
Sbjct: 535 ARGTVGFSGAELENLVN--QAALKAAVDG 561
>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
Length = 716
Score = 62.4 bits (150), Expect = 1e-09
Identities = 61/209 (29%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 344 LYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 402
L + ILL GPPGTGKTL A+ +A + + + +G + M G + + LF A +
Sbjct: 314 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 372
Query: 403 RRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM-GQHSNKFMLVL-ASNLPEQFD 460
++F+DE D+ KR + R T+N L M G N+ ++++ A+N PE D
Sbjct: 373 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 432
Query: 461 CAI--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEV 518
A+ R D+ V P + R +++ + L +FD +
Sbjct: 433 NALIRPGRFDMQVTVPRPDVKGRTEILKWY---------------LNKIKFDQSVDPEII 477
Query: 519 ARLTEGMSGREIAQLAVSWQATAYASKDG 547
AR T G SG E+ L QA A+ DG
Sbjct: 478 ARGTVGFSGAELENLVN--QAALKAAVDG 504
>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
Length = 893
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/143 (32%), Positives = 75/143 (52%), Gaps = 8/143 (5%)
Query: 346 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 404
R +LLYGPPGTGKT+ A+ +A G +++ G + ++ E + ++F A T R
Sbjct: 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA-TLRH 446
Query: 405 GLLLFMDEADAFLRKR--ATEEISKDLRATLNAFLYHMGQH-SNKFMLVL-ASNLPEQFD 460
++F+DE DA KR A E+ K + A+L + +G S +LVL A+N P D
Sbjct: 447 PSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALD 506
Query: 461 CAIN--SRIDVMVHFDLPQQEER 481
A+ R D + +P ++R
Sbjct: 507 AALRRPGRFDKEIEIGVPNAQDR 529
Score = 53.5 bits (127), Expect = 6e-07
Identities = 54/214 (25%), Positives = 95/214 (44%), Gaps = 26/214 (12%)
Query: 348 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVA-PMGREGVTAMHKLFDWANTSRRGL 406
+LLYGPPG KT+ AK LA SG+++ + G ++ E A+ + F A
Sbjct: 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPS- 722
Query: 407 LLFMDEADAFLRKRATE----EISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCA 462
++F DE DA +R + ++ + A L + + Q + +L A+N P++ D A
Sbjct: 723 IIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILA-ATNRPDRIDKA 781
Query: 463 I--NSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVAR 520
+ RID +++ LP R + +L F + + + E+
Sbjct: 782 LMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVD---------------LDELIL 826
Query: 521 LTEGMSGREIAQLAVSWQATAYASKDGVLTEAMM 554
T+ SG EI +AV +A A ++ + +M
Sbjct: 827 QTDAYSGAEI--VAVCREAALLALEEDIQANLIM 858
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 61.2 bits (147), Expect = 3e-09
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTL--QLEQQSKLKEYEAAVE 101
K K + + E +A RE E + +E L + QE+ L Q E++ K +E E
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 781
Query: 102 QLKSEQIRAQAEER---RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRK 158
+ + E +R Q E+ R+ EE RQ Q A + + R+ E++ KQ++LL RK
Sbjct: 782 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL-----RK 836
Query: 159 QEESVQKQEAMRRATVEREMELRHKNEMLRVETE-ARARAKAERENADIIREQIRLKASE 217
QEE EA + A E E + R + LR+E E AR R + E + Q + +
Sbjct: 837 QEE-----EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMR 891
Query: 218 HRQTVLESIR 227
RQ E++R
Sbjct: 892 QRQQQQEALR 901
Score = 48.5 bits (114), Expect = 2e-05
Identities = 44/135 (32%), Positives = 69/135 (51%), Gaps = 25/135 (18%)
Query: 87 LEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK 146
LEQ +L++ +AA K EQ R +AE R K EE ++ Q++L RQ+ E +
Sbjct: 717 LEQLQQLEKAKAA----KLEQERREAEMRAKREEEERKR-------QEELRRQQEEILRR 765
Query: 147 QQQLLNEENLRKQEESV--QKQEAMRRATVEREMELR---------HKNEMLRVETEARA 195
QQ+ EE R++EE + +KQE R E+E+ LR + E LR E R
Sbjct: 766 QQE---EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 822
Query: 196 RAKAERENADIIREQ 210
+ R+ +++R+Q
Sbjct: 823 EEEERRKQEELLRKQ 837
Score = 43.5 bits (101), Expect = 6e-04
Identities = 32/128 (25%), Positives = 67/128 (52%), Gaps = 6/128 (4%)
Query: 56 ERAAKAARELEHS-RYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
E A + RE E + R +E Q +E +LE++ + +E E+L +Q A+
Sbjct: 785 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 844
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQ---LKQQQLLNEENLRKQEESVQKQEAMRR 171
R+ + R + R + +++ AR R+E++ K+ ++ ++ L +Q + Q+QEA+RR
Sbjct: 845 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--QQQEALRR 902
Query: 172 ATVEREME 179
+++ +
Sbjct: 903 LQQQQQQQ 910
Score = 38.5 bits (88), Expect = 0.019
Identities = 34/157 (21%), Positives = 68/157 (43%), Gaps = 6/157 (3%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQ---QSKLKEYEAAVEQLKSEQIRAQ 111
L R + RE E R +E L + + E+ Q +L+E +E+ + +
Sbjct: 814 LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 873
Query: 112 AEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 171
E +RK L + ++ R + Q + A +R + Q +QQQL ++ S Q++
Sbjct: 874 EERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPSSSTWGQQSNTT 930
Query: 172 ATVEREMELRHKNEMLRVETEARARAKAERENADIIR 208
A + + + L E E + R + R+ ++++
Sbjct: 931 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 967
Score = 37.0 bits (84), Expect = 0.057
Identities = 36/175 (20%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQM----QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQ 111
E A + RE E + +EAL + +E+ + E+ + +E EAA + E+ + +
Sbjct: 795 EIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRR 854
Query: 112 AEERRKTLSEETRQ--HQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAM 169
EE R + EE + H+ + + +L QR ++ ++Q+Q +Q+E++++ +
Sbjct: 855 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--------QQQEALRRLQQQ 906
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAERENADIIR----EQIRLKASEHRQ 220
++ +M+L + + +++A A+I + + +L+ + RQ
Sbjct: 907 QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 961
Score = 34.3 bits (77), Expect = 0.37
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + +ELE R KE + Q Q++ L+ QQ + ++ + A +L S Q
Sbjct: 872 EEEERKRKELEVQRQ-KELMRQRQQQQEALRRLQQQQ-QQQQLAQMKLPSSSTWGQQSNT 929
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 165
S+ T + +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 930 TACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 979
Score = 30.8 bits (68), Expect = 4.1
Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 20/112 (17%)
Query: 68 SRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQ 127
S + +++ A + TL L + KL+E QL+ EQ R Q E K L ++ +Q Q
Sbjct: 921 STWGQQSNTTACQSQATLSLAEIQKLEEERE--RQLREEQ-RRQQRELMKALQQQQQQQQ 977
Query: 128 ARA-----------------QYQDKLARQRYEDQLKQQQLLNEENLRKQEES 162
+ + Q + ARQ + Q +QQQ R S
Sbjct: 978 QKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1029
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 61.2 bits (147), Expect = 3e-09
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTL--QLEQQSKLKEYEAAVE 101
K K + + E +A RE E + +E L + QE+ L Q E++ K +E E
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 808
Query: 102 QLKSEQIRAQAEER---RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRK 158
+ + E +R Q E+ R+ EE RQ Q A + + R+ E++ KQ++LL RK
Sbjct: 809 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL-----RK 863
Query: 159 QEESVQKQEAMRRATVEREMELRHKNEMLRVETE-ARARAKAERENADIIREQIRLKASE 217
QEE EA + A E E + R + LR+E E AR R + E + Q + +
Sbjct: 864 QEE-----EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMR 918
Query: 218 HRQTVLESIR 227
RQ E++R
Sbjct: 919 QRQQQQEALR 928
Score = 48.5 bits (114), Expect = 2e-05
Identities = 44/135 (32%), Positives = 69/135 (51%), Gaps = 25/135 (18%)
Query: 87 LEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK 146
LEQ +L++ +AA K EQ R +AE R K EE ++ Q++L RQ+ E +
Sbjct: 744 LEQLQQLEKAKAA----KLEQERREAEMRAKREEEERKR-------QEELRRQQEEILRR 792
Query: 147 QQQLLNEENLRKQEESV--QKQEAMRRATVEREMELR---------HKNEMLRVETEARA 195
QQ+ EE R++EE + +KQE R E+E+ LR + E LR E R
Sbjct: 793 QQE---EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 849
Query: 196 RAKAERENADIIREQ 210
+ R+ +++R+Q
Sbjct: 850 EEEERRKQEELLRKQ 864
Score = 43.5 bits (101), Expect = 6e-04
Identities = 32/128 (25%), Positives = 67/128 (52%), Gaps = 6/128 (4%)
Query: 56 ERAAKAARELEHS-RYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
E A + RE E + R +E Q +E +LE++ + +E E+L +Q A+
Sbjct: 812 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 871
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQ---LKQQQLLNEENLRKQEESVQKQEAMRR 171
R+ + R + R + +++ AR R+E++ K+ ++ ++ L +Q + Q+QEA+RR
Sbjct: 872 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--QQQEALRR 929
Query: 172 ATVEREME 179
+++ +
Sbjct: 930 LQQQQQQQ 937
Score = 38.5 bits (88), Expect = 0.019
Identities = 34/157 (21%), Positives = 68/157 (43%), Gaps = 6/157 (3%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQ---QSKLKEYEAAVEQLKSEQIRAQ 111
L R + RE E R +E L + + E+ Q +L+E +E+ + +
Sbjct: 841 LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 900
Query: 112 AEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 171
E +RK L + ++ R + Q + A +R + Q +QQQL ++ S Q++
Sbjct: 901 EERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPSSSTWGQQSNTT 957
Query: 172 ATVEREMELRHKNEMLRVETEARARAKAERENADIIR 208
A + + + L E E + R + R+ ++++
Sbjct: 958 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 994
Score = 37.0 bits (84), Expect = 0.057
Identities = 36/175 (20%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQM----QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQ 111
E A + RE E + +EAL + +E+ + E+ + +E EAA + E+ + +
Sbjct: 822 EIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRR 881
Query: 112 AEERRKTLSEETRQ--HQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAM 169
EE R + EE + H+ + + +L QR ++ ++Q+Q +Q+E++++ +
Sbjct: 882 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--------QQQEALRRLQQQ 933
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAERENADIIR----EQIRLKASEHRQ 220
++ +M+L + + +++A A+I + + +L+ + RQ
Sbjct: 934 QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 988
Score = 34.3 bits (77), Expect = 0.37
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + +ELE R KE + Q Q++ L+ QQ + ++ + A +L S Q
Sbjct: 899 EEEERKRKELEVQRQ-KELMRQRQQQQEALRRLQQQQ-QQQQLAQMKLPSSSTWGQQSNT 956
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 165
S+ T + +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 957 TACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 1006
Score = 30.8 bits (68), Expect = 4.1
Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 20/112 (17%)
Query: 68 SRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQ 127
S + +++ A + TL L + KL+E QL+ EQ R Q E K L ++ +Q Q
Sbjct: 948 STWGQQSNTTACQSQATLSLAEIQKLEEERE--RQLREEQ-RRQQRELMKALQQQQQQQQ 1004
Query: 128 ARA-----------------QYQDKLARQRYEDQLKQQQLLNEENLRKQEES 162
+ + Q + ARQ + Q +QQQ R S
Sbjct: 1005 QKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1056
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 61.2 bits (147), Expect = 3e-09
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTL--QLEQQSKLKEYEAAVE 101
K K + + E +A RE E + +E L + QE+ L Q E++ K +E E
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 787
Query: 102 QLKSEQIRAQAEER---RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRK 158
+ + E +R Q E+ R+ EE RQ Q A + + R+ E++ KQ++LL RK
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL-----RK 842
Query: 159 QEESVQKQEAMRRATVEREMELRHKNEMLRVETE-ARARAKAERENADIIREQIRLKASE 217
QEE EA + A E E + R + LR+E E AR R + E + Q + +
Sbjct: 843 QEE-----EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMR 897
Query: 218 HRQTVLESIR 227
RQ E++R
Sbjct: 898 QRQQQQEALR 907
Score = 48.5 bits (114), Expect = 2e-05
Identities = 44/135 (32%), Positives = 69/135 (51%), Gaps = 25/135 (18%)
Query: 87 LEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK 146
LEQ +L++ +AA K EQ R +AE R K EE ++ Q++L RQ+ E +
Sbjct: 723 LEQLQQLEKAKAA----KLEQERREAEMRAKREEEERKR-------QEELRRQQEEILRR 771
Query: 147 QQQLLNEENLRKQEESV--QKQEAMRRATVEREMELR---------HKNEMLRVETEARA 195
QQ+ EE R++EE + +KQE R E+E+ LR + E LR E R
Sbjct: 772 QQE---EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 196 RAKAERENADIIREQ 210
+ R+ +++R+Q
Sbjct: 829 EEEERRKQEELLRKQ 843
Score = 43.5 bits (101), Expect = 6e-04
Identities = 32/128 (25%), Positives = 67/128 (52%), Gaps = 6/128 (4%)
Query: 56 ERAAKAARELEHS-RYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
E A + RE E + R +E Q +E +LE++ + +E E+L +Q A+
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQ---LKQQQLLNEENLRKQEESVQKQEAMRR 171
R+ + R + R + +++ AR R+E++ K+ ++ ++ L +Q + Q+QEA+RR
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--QQQEALRR 908
Query: 172 ATVEREME 179
+++ +
Sbjct: 909 LQQQQQQQ 916
Score = 38.5 bits (88), Expect = 0.019
Identities = 34/157 (21%), Positives = 68/157 (43%), Gaps = 6/157 (3%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQ---QSKLKEYEAAVEQLKSEQIRAQ 111
L R + RE E R +E L + + E+ Q +L+E +E+ + +
Sbjct: 820 LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 879
Query: 112 AEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 171
E +RK L + ++ R + Q + A +R + Q +QQQL ++ S Q++
Sbjct: 880 EERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPSSSTWGQQSNTT 936
Query: 172 ATVEREMELRHKNEMLRVETEARARAKAERENADIIR 208
A + + + L E E + R + R+ ++++
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 973
Score = 37.0 bits (84), Expect = 0.057
Identities = 36/175 (20%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQM----QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQ 111
E A + RE E + +EAL + +E+ + E+ + +E EAA + E+ + +
Sbjct: 801 EIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRR 860
Query: 112 AEERRKTLSEETRQ--HQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAM 169
EE R + EE + H+ + + +L QR ++ ++Q+Q +Q+E++++ +
Sbjct: 861 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--------QQQEALRRLQQQ 912
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAERENADIIR----EQIRLKASEHRQ 220
++ +M+L + + +++A A+I + + +L+ + RQ
Sbjct: 913 QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 967
Score = 34.3 bits (77), Expect = 0.37
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + +ELE R KE + Q Q++ L+ QQ + ++ + A +L S Q
Sbjct: 878 EEEERKRKELEVQRQ-KELMRQRQQQQEALRRLQQQQ-QQQQLAQMKLPSSSTWGQQSNT 935
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 165
S+ T + +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 936 TACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 985
Score = 30.8 bits (68), Expect = 4.1
Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 20/112 (17%)
Query: 68 SRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQ 127
S + +++ A + TL L + KL+E QL+ EQ R Q E K L ++ +Q Q
Sbjct: 927 STWGQQSNTTACQSQATLSLAEIQKLEEERE--RQLREEQ-RRQQRELMKALQQQQQQQQ 983
Query: 128 ARA-----------------QYQDKLARQRYEDQLKQQQLLNEENLRKQEES 162
+ + Q + ARQ + Q +QQQ R S
Sbjct: 984 QKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1035
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 61.2 bits (147), Expect = 3e-09
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 19/190 (10%)
Query: 44 KDKWSNFDPTGLERAAKAARELEHSRYAKEALNLAQMQEQTL--QLEQQSKLKEYEAAVE 101
K K + + E +A RE E + +E L + QE+ L Q E++ K +E E
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQEE---LRRQQEEILRRQQEEERKRREEEELAR 787
Query: 102 QLKSEQIRAQAEER---RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRK 158
+ + E +R Q E+ R+ EE RQ Q A + + R+ E++ KQ++LL RK
Sbjct: 788 RKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL-----RK 842
Query: 159 QEESVQKQEAMRRATVEREMELRHKNEMLRVETE-ARARAKAERENADIIREQIRLKASE 217
QEE EA + A E E + R + LR+E E AR R + E + Q + +
Sbjct: 843 QEE-----EAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMR 897
Query: 218 HRQTVLESIR 227
RQ E++R
Sbjct: 898 QRQQQQEALR 907
Score = 48.5 bits (114), Expect = 2e-05
Identities = 44/135 (32%), Positives = 69/135 (51%), Gaps = 25/135 (18%)
Query: 87 LEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLK 146
LEQ +L++ +AA K EQ R +AE R K EE ++ Q++L RQ+ E +
Sbjct: 723 LEQLQQLEKAKAA----KLEQERREAEMRAKREEEERKR-------QEELRRQQEEILRR 771
Query: 147 QQQLLNEENLRKQEESV--QKQEAMRRATVEREMELR---------HKNEMLRVETEARA 195
QQ+ EE R++EE + +KQE R E+E+ LR + E LR E R
Sbjct: 772 QQE---EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 828
Query: 196 RAKAERENADIIREQ 210
+ R+ +++R+Q
Sbjct: 829 EEEERRKQEELLRKQ 843
Score = 43.5 bits (101), Expect = 6e-04
Identities = 32/128 (25%), Positives = 67/128 (52%), Gaps = 6/128 (4%)
Query: 56 ERAAKAARELEHS-RYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEE 114
E A + RE E + R +E Q +E +LE++ + +E E+L +Q A+
Sbjct: 791 EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850
Query: 115 RRKTLSEETRQHQARAQYQDKLARQRYEDQ---LKQQQLLNEENLRKQEESVQKQEAMRR 171
R+ + R + R + +++ AR R+E++ K+ ++ ++ L +Q + Q+QEA+RR
Sbjct: 851 AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--QQQEALRR 908
Query: 172 ATVEREME 179
+++ +
Sbjct: 909 LQQQQQQQ 916
Score = 38.5 bits (88), Expect = 0.019
Identities = 34/157 (21%), Positives = 68/157 (43%), Gaps = 6/157 (3%)
Query: 55 LERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQ---QSKLKEYEAAVEQLKSEQIRAQ 111
L R + RE E R +E L + + E+ Q +L+E +E+ + +
Sbjct: 820 LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 879
Query: 112 AEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRR 171
E +RK L + ++ R + Q + A +R + Q +QQQL ++ S Q++
Sbjct: 880 EERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL---AQMKLPSSSTWGQQSNTT 936
Query: 172 ATVEREMELRHKNEMLRVETEARARAKAERENADIIR 208
A + + + L E E + R + R+ ++++
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMK 973
Score = 37.0 bits (84), Expect = 0.057
Identities = 36/175 (20%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQM----QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQ 111
E A + RE E + +EAL + +E+ + E+ + +E EAA + E+ + +
Sbjct: 801 EIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRR 860
Query: 112 AEERRKTLSEETRQ--HQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAM 169
EE R + EE + H+ + + +L QR ++ ++Q+Q +Q+E++++ +
Sbjct: 861 LEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQ--------QQQEALRRLQQQ 912
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAERENADIIR----EQIRLKASEHRQ 220
++ +M+L + + +++A A+I + + +L+ + RQ
Sbjct: 913 QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQ 967
Score = 34.3 bits (77), Expect = 0.37
Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 2/110 (1%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + +ELE R KE + Q Q++ L+ QQ + ++ + A +L S Q
Sbjct: 878 EEEERKRKELEVQRQ-KELMRQRQQQQEALRRLQQQQ-QQQQLAQMKLPSSSTWGQQSNT 935
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK 165
S+ T + +++ RQ E+Q +QQ+ L + ++Q++ QK
Sbjct: 936 TACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK 985
Score = 30.8 bits (68), Expect = 4.1
Identities = 29/112 (25%), Positives = 45/112 (40%), Gaps = 20/112 (17%)
Query: 68 SRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQ 127
S + +++ A + TL L + KL+E QL+ EQ R Q E K L ++ +Q Q
Sbjct: 927 STWGQQSNTTACQSQATLSLAEIQKLEEERE--RQLREEQ-RRQQRELMKALQQQQQQQQ 983
Query: 128 ARA-----------------QYQDKLARQRYEDQLKQQQLLNEENLRKQEES 162
+ + Q + ARQ + Q +QQQ R S
Sbjct: 984 QKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1035
>gi|31742536 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/149 (30%), Positives = 75/149 (50%), Gaps = 7/149 (4%)
Query: 342 RGLYRHILLYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAN 400
RG + ILL+GPPGTGKTL K +A SG ++I + EG + LF A
Sbjct: 431 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR 490
Query: 401 TSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMG----QHSNKFMLVLASNLP 456
++ ++F+DE D+ L +R E + R FL + ++ ++V A+N P
Sbjct: 491 -CQQPAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRP 548
Query: 457 EQFDCAINSRIDVMVHFDLPQQEERERLV 485
++ D A R+ ++ LP+ R+++V
Sbjct: 549 QEIDEAARRRLVKRLYIPLPEASARKQIV 577
>gi|112789543 fidgetin-like 1 [Homo sapiens]
Length = 674
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/149 (30%), Positives = 75/149 (50%), Gaps = 7/149 (4%)
Query: 342 RGLYRHILLYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAN 400
RG + ILL+GPPGTGKTL K +A SG ++I + EG + LF A
Sbjct: 431 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR 490
Query: 401 TSRRGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMG----QHSNKFMLVLASNLP 456
++ ++F+DE D+ L +R E + R FL + ++ ++V A+N P
Sbjct: 491 -CQQPAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRP 548
Query: 457 EQFDCAINSRIDVMVHFDLPQQEERERLV 485
++ D A R+ ++ LP+ R+++V
Sbjct: 549 QEIDEAARRRLVKRLYIPLPEASARKQIV 577
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.8 bits (146), Expect = 4e-09
Identities = 45/153 (29%), Positives = 81/153 (52%), Gaps = 8/153 (5%)
Query: 63 RELEHSRYAKEALNLAQM-QEQTLQL-EQQSKLKEYEAAVEQLKSEQIRAQAE--ERRKT 118
RE E R +E + + QEQ ++ Q+ K++E E + + + + R + + E+ K
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI 452
Query: 119 LSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREM 178
EE RQ Q Q++ R++ E +++++ +E +RKQEE V +QE ++E
Sbjct: 453 REEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMH---DQEE 509
Query: 179 ELRHKNE-MLRVETEARARAKAERENADIIREQ 210
++R + E M R E + R + + RE + IREQ
Sbjct: 510 KIREQEEKMWRQEEKIREQEEKIREQEEKIREQ 542
Score = 58.5 bits (140), Expect = 2e-08
Identities = 45/163 (27%), Positives = 85/163 (52%), Gaps = 15/163 (9%)
Query: 58 AAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRK 117
+AK ++E + E N Q++ Q+ K++E+E +++ + E+IR Q E+ R+
Sbjct: 278 SAKLQAQVEEN----ELWNRLNQQQEEKMWRQEEKIQEWEEKIQE-QEEKIREQEEKIRE 332
Query: 118 TLSEETRQHQARAQYQDKLARQR---YEDQLKQQQLLN-----EENLRKQEESVQKQEAM 169
+ RQ + + ++K+ RQ +E + K ++L EE +R+ EE + +QE +
Sbjct: 333 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI 392
Query: 170 RRATVEREMELRHKNEMLRVETEARARAKAE--RENADIIREQ 210
R +R+ E + + + R E EA+ + E RE + IREQ
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 435
Score = 57.0 bits (136), Expect = 5e-08
Identities = 47/178 (26%), Positives = 89/178 (50%), Gaps = 23/178 (12%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQ--MQEQTLQLEQQSKLKEYEAAVEQ----LKSEQIR 109
E+ AK R+ E R +E + + M Q ++ +Q K++E E EQ + E+IR
Sbjct: 413 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 472
Query: 110 AQAE-----------ERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNE--ENL 156
Q E E+ + E+ + + + Q++ R++ E +Q++ + E E +
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKI 532
Query: 157 RKQEESVQKQEAMRRATVER----EMELRHKNEMLRVETEARARAKAERENADIIREQ 210
R+QEE +++QE M + E+ E +++ + +M R E + R + + RE + IREQ
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Score = 54.7 bits (130), Expect = 3e-07
Identities = 46/186 (24%), Positives = 92/186 (49%), Gaps = 24/186 (12%)
Query: 66 EHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQ 125
E + +E L L + ++ +QL + ++ E A L +Q++A+A+ K L + +
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 126 HQARAQYQD---KLARQRYEDQLKQQQLLNE---------ENLRKQEESVQKQ-EAMRRA 172
QA+ + + +L +Q+ E +Q++ + E E +R+QEE +++Q E MRR
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 173 TV---EREMELRHKNEML--------RVETEARARAKAERENADIIREQIRLKASEHRQT 221
E+E ++R + EM+ R+E + + RE + + EQ +++ E ++
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400
Query: 222 VLESIR 227
E IR
Sbjct: 401 EEEKIR 406
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/142 (25%), Positives = 76/142 (53%), Gaps = 9/142 (6%)
Query: 81 QEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQR 140
QE+ ++ EQ+ K++E E E+++ ++ Q +E + EE Q Q + + Q++ R++
Sbjct: 521 QEEKIR-EQEEKIREQE---EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576
Query: 141 YEDQLKQQQLLNE--ENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVETEARAR-A 197
E +Q++ + E E + +QEE +++QE M + E+ E K M E + + +
Sbjct: 577 EEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK--MCEQEEKMQEQEE 634
Query: 198 KAERENADIIREQIRLKASEHR 219
K R+ + +++RL+ E +
Sbjct: 635 KMRRQEEKMWEQEVRLRQQEEK 656
Score = 50.8 bits (120), Expect = 4e-06
Identities = 36/157 (22%), Positives = 87/157 (55%), Gaps = 12/157 (7%)
Query: 63 RELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEE 122
R LE + KE +++E ++ +Q K++E E ++ + E+IR Q E+R++ ++
Sbjct: 366 RRLEEMMWEKEE----KIRELEEKMHEQEKIREQEE--KRQEEEKIREQ-EKRQEQEAKM 418
Query: 123 TRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRH 182
RQ + + ++K+ R++ + +Q++ ++E+ ++EE Q+QE M R +E ++R
Sbjct: 419 WRQEEKIREQEEKI-REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR----QEEKIRE 473
Query: 183 KNEMLRVETEARARAKAERENADIIREQIRLKASEHR 219
+ E+ R + + + K ++ + R++ ++ E +
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Score = 47.8 bits (112), Expect = 3e-05
Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 10/137 (7%)
Query: 56 ERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEER 115
E + E+ + K +MQEQ Q+ K++E E + + K E+IR Q EE+
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQK-EKIREQ-EEK 593
Query: 116 RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVE 175
E+ R+ + Q Q++ ++ E +Q EE +++QEE +++QE E
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-----EEKMQEQEEKMRRQE---EKMWE 645
Query: 176 REMELRHKNEMLRVETE 192
+E+ LR + E ++ E
Sbjct: 646 QEVRLRQQEEKMQEHQE 662
>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/199 (23%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 345 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 403
++ +L+ GPPGTGKT+ AK +A G + ++ + R E + LF+ A
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR-FY 299
Query: 404 RGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM---------GQHSNKFMLVLASN 454
+F+DE D+ +R T + + R + L M S M++ A+N
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359
Query: 455 LPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRK 514
P D A+ R++ ++ LP + R L++++ L+ + D +
Sbjct: 360 FPWDIDEALRRRLEKRIYIPLPTAKGRAELLKIN---------------LREVELDPDIQ 404
Query: 515 CSEVARLTEGMSGREIAQL 533
++A EG SG +I +
Sbjct: 405 LEDIAEKIEGYSGADITNV 423
>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
Length = 490
Score = 60.8 bits (146), Expect = 4e-09
Identities = 47/199 (23%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 345 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 403
++ +L+ GPPGTGKT+ AK +A G + ++ + R E + LF+ A
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR-FY 299
Query: 404 RGLLLFMDEADAFLRKRATEEISKDLRATLNAFLYHM---------GQHSNKFMLVLASN 454
+F+DE D+ +R T + + R + L M S M++ A+N
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359
Query: 455 LPEQFDCAINSRIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRK 514
P D A+ R++ ++ LP + R L++++ L+ + D +
Sbjct: 360 FPWDIDEALRRRLEKRIYIPLPTAKGRAELLKIN---------------LREVELDPDIQ 404
Query: 515 CSEVARLTEGMSGREIAQL 533
++A EG SG +I +
Sbjct: 405 LEDIAEKIEGYSGADITNV 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,902,668
Number of Sequences: 37866
Number of extensions: 1310434
Number of successful extensions: 19380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 972
Number of HSP's that attempted gapping in prelim test: 11407
Number of HSP's gapped (non-prelim): 5824
length of query: 648
length of database: 18,247,518
effective HSP length: 109
effective length of query: 539
effective length of database: 14,120,124
effective search space: 7610746836
effective search space used: 7610746836
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.