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Search of human proteins with 74271814
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74271814 NLR family, pyrin domain containing 1 isoform 5
[Homo sapiens]
(1375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 2808 0.0
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 2753 0.0
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 2682 0.0
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 2642 0.0
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 2570 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 492 e-139
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 464 e-130
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 463 e-130
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 463 e-130
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 450 e-126
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 443 e-124
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 427 e-119
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 341 3e-93
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 339 1e-92
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 333 9e-91
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 330 6e-90
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 324 4e-88
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 322 1e-87
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 319 1e-86
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 319 1e-86
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 314 3e-85
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 281 2e-75
gi|7662404 caspase recruitment domain family, member 8 [Homo sap... 271 2e-72
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 252 2e-66
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 250 6e-66
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 151 5e-36
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 141 5e-33
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 141 5e-33
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 141 5e-33
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 141 5e-33
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 2808 bits (7280), Expect = 0.0
Identities = 1375/1375 (100%), Positives = 1375/1375 (100%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
Query: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
Query: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
Sbjct: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY 1375
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY
Sbjct: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGRNTSQPWNLRCNRDARRY 1375
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 2753 bits (7137), Expect = 0.0
Identities = 1353/1357 (99%), Positives = 1353/1357 (99%), Gaps = 4/1357 (0%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
ASHVAQANLKLLDVSKIFPIAEIA EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1076
Query: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1077 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1136
Query: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1137 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
Sbjct: 1257 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1316
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1317 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1353
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 2682 bits (6951), Expect = 0.0
Identities = 1323/1357 (97%), Positives = 1323/1357 (97%), Gaps = 34/1357 (2%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
Query: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 958 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
ASHVAQANLKLLDVSKIFPIAEIA EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 991 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1046
Query: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1047 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1106
Query: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1107 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE
Sbjct: 1227 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1286
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1287 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1323
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 2642 bits (6847), Expect = 0.0
Identities = 1309/1357 (96%), Positives = 1309/1357 (96%), Gaps = 48/1357 (3%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
Query: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
ASHVAQANLKLLDVSKIFPIAEIA EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 1021 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1076
Query: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1077 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1136
Query: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1137 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1196
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1197 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1256
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
CSIR KELELCYRSPGE
Sbjct: 1257 CSIR--------------------------------------------KELELCYRSPGE 1272
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1273 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1309
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 2570 bits (6661), Expect = 0.0
Identities = 1279/1357 (94%), Positives = 1279/1357 (94%), Gaps = 78/1357 (5%)
Query: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ
Sbjct: 1 MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ 60
Query: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW
Sbjct: 61 YGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPW 120
Query: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST
Sbjct: 121 IHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTST 180
Query: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT
Sbjct: 181 AVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGT 240
Query: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW
Sbjct: 241 PPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW 300
Query: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR
Sbjct: 301 PDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDR 360
Query: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ
Sbjct: 361 FQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQ 420
Query: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG
Sbjct: 421 EPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLG 480
Query: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL
Sbjct: 481 FSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAI 600
Query: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY
Sbjct: 601 ISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAY 660
Query: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH
Sbjct: 661 GIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLH 720
Query: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWS 780
Query: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE
Sbjct: 781 PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLE 840
Query: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQ 960
LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--- 957
Query: 961 TTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 1020
KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA
Sbjct: 958 ---------------------------KPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERA 990
Query: 1021 ASHVAQANLKLLDVSKIFPIAEIAGKSHEESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1080
ASHVAQANLKLLDVSKIFPIAEIA EESSPEVVPVELLCVPSPASQGDLHTKPLGTD
Sbjct: 991 ASHVAQANLKLLDVSKIFPIAEIA----EESSPEVVPVELLCVPSPASQGDLHTKPLGTD 1046
Query: 1081 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1140
DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL
Sbjct: 1047 DDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFL 1106
Query: 1141 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK
Sbjct: 1107 GEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1166
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD
Sbjct: 1167 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1226
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
CSIR KELELCYRSPGE
Sbjct: 1227 CSIR--------------------------------------------KELELCYRSPGE 1242
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1357
DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG
Sbjct: 1243 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG 1279
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 492 bits (1267), Expect = e-139
Identities = 325/813 (39%), Positives = 448/813 (55%), Gaps = 65/813 (7%)
Query: 273 DFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHL---------IEIRDLFGPGLD 323
+ + ++T+LLL++ +P+ + ++ RGH I+I LF P +
Sbjct: 152 NLSHRYTRLLLVKE----HSNPMQVQQ--QLLDTGRGHARTVGHQASPIKIETLFEPDEE 205
Query: 324 TQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKV-VSLA 381
EP R V++QGAAGIGKS LA +V W G+L+ RF ++FY +CRE+ QS S+
Sbjct: 206 RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQ 265
Query: 382 ELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLG 441
+LI AP+++++ PERLLFI+DG DE +P CL W + +P + LL
Sbjct: 266 DLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLN 325
Query: 442 SLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAI 501
SL+ K +LPE S LIT R TAL+ L LE R VE+LGFSE+ RKEYFY+YF + QA
Sbjct: 326 SLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAG 385
Query: 502 RAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQA 561
+ F V+ N+ L+ +C VP V W+ CTCL QQ++ L TS+TTT + + YL +Q
Sbjct: 386 QVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQP 445
Query: 562 QPLGPQL------RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH-P 614
+P P+L R LCSLAA+G+W +K LF DLRKHGLDG +S FL M I Q+
Sbjct: 446 KPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDIN 505
Query: 615 IPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTR 672
YSFIHL FQEFFAAM Y+L E E G G D+ + L Y F A T+R
Sbjct: 506 CERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQ----DVTRLLTEYAFSERSFLALTSR 561
Query: 673 FLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQ----LLLQPHSLESLHCLYETR 726
FL GLL++E +E ++S +L+QW+ S LQ SLE CLYE +
Sbjct: 562 FLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQ 621
Query: 727 NKTFLTQVMAHFEEMGMC-VETDMELLVCTFCIKFSRHVKKLQLI--------EGRQHRS 777
+ F+ Q ++HF+ + + + + ME +V +FC+K R + L L E R S
Sbjct: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCS 681
Query: 778 TWSPTMVV-LFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPR 836
+ T++V L + DAY + L + L NL EL L N+L VK LC+ LR P
Sbjct: 682 AGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPN 741
Query: 837 CLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKL 896
C L+ LRL C +++ C+DL+ L AN+ LT +DLS N + G LC+ LR P C+L
Sbjct: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 801
Query: 897 QRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Q +QL C L S CQ++ASVL +P L ELDL N L+D+G+RLLC+GLRHP C+L L
Sbjct: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
Query: 957 GL----------DQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNS 1006
L D+ + + Q LR L+ +L V+ EGL
Sbjct: 862 WLKICRLTAAACDELASTLSVNQSLRELDLSLNEL-----GDLGVLLLCEGLRHPTCKLQ 916
Query: 1007 TSSLKRQRLGSE--RAASHVAQA--NLKLLDVS 1035
T L RLGS S V QA NL+ LD+S
Sbjct: 917 TLRLGICRLGSAACEGLSVVLQANHNLRELDLS 949
Score = 149 bits (376), Expect = 2e-35
Identities = 85/174 (48%), Positives = 110/174 (63%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L C L S C+ L+ V
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
L A+ +L+ELDL N+L D G+ LL EGL+HPAC+L +L LD L+ + + L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENL 990
Score = 145 bits (366), Expect = 3e-34
Identities = 87/190 (45%), Positives = 110/190 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL C L +
Sbjct: 868 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGS 927
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+AN L ELDLSFN L D G L + L+ P+C+LQ+L L SCGLT+ C
Sbjct: 928 AACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKAC 987
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
++L L + +L +L L N L D GVRLLC+ L HP CKL L L L+ L
Sbjct: 988 ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 1047
Query: 972 RALEQEKPQL 981
AL KP L
Sbjct: 1048 AALRVTKPYL 1057
Score = 54.7 bits (130), Expect = 6e-07
Identities = 48/165 (29%), Positives = 75/165 (45%), Gaps = 6/165 (3%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRA 66
RL+ YLE L+ ELK+F+L L + G+ P EK +E+A L+ +G + A
Sbjct: 12 RLSTYLEELEAVELKKFKLYLGTA--TELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69
Query: 67 WDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPA 126
W LAL T+E++ + L + Q + P PS LG+ S V + + P
Sbjct: 70 WRLALSTFERINRKDLWERGQREDLVRDTPPGGPSS--LGNQS-TCLLEVSLVTPRKDPQ 126
Query: 127 GCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQ 171
+ RR R + D + R ++ S Y L +H +P Q
Sbjct: 127 ETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQ 171
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 464 bits (1193), Expect = e-130
Identities = 285/709 (40%), Positives = 397/709 (55%), Gaps = 50/709 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LV+ GLTS CC L+SVLS + +L
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
L L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 859 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
Score = 79.3 bits (194), Expect = 2e-14
Identities = 48/133 (36%), Positives = 65/133 (48%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T L SVL +NL L L GN+L +K LC+ L P C L+ L L C LT+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C DL+ L ++Q+L +L L N L D G C+ L+Q SC LQ L L +
Sbjct: 899 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
Query: 912 QDLASVLSASPSL 924
L ++ P L
Sbjct: 959 SALETLQEEKPEL 971
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 463 bits (1192), Expect = e-130
Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LVSC LTS CCQDLASVLS S SL
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
L + +N L D GV +LCE ++P C L +LGL + L+
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Score = 148 bits (374), Expect = 3e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 839 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 899 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 959 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
Query: 972 RALEQEKPQLLI 983
L++EKP+L +
Sbjct: 1019 ETLQEEKPELTV 1030
Score = 136 bits (342), Expect = 2e-31
Identities = 76/172 (44%), Positives = 101/172 (58%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL + L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
+ +LT L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS +
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
+L L L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 463 bits (1192), Expect = e-130
Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805
K RH+ +Q + + S +V +T ++ + LFSVL
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865
+++L ELDLS NSL ++ LC+TL+ P C + L L CGL+ E C D++ L +NQ
Sbjct: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
Query: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925
L ELDLS N L D G + LC L+ C L++L LVSC LTS CCQDLASVLS S SL
Sbjct: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
Query: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
L + +N L D GV +LCE ++P C L +LGL + L+
Sbjct: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
Score = 148 bits (374), Expect = 3e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 839 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 899 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 959 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
Query: 972 RALEQEKPQLLI 983
L++EKP+L +
Sbjct: 1019 ETLQEEKPELTV 1030
Score = 136 bits (342), Expect = 2e-31
Identities = 76/172 (44%), Positives = 101/172 (58%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL + L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
+ +LT L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS +
Sbjct: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
+L L L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 450 bits (1158), Expect = e-126
Identities = 282/715 (39%), Positives = 396/715 (55%), Gaps = 44/715 (6%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
EGR S+ + L R + + I VL +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
L ELDLS N+L ++ LC L+ C L+ L L GLT+ C L+ L NQ LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 801
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
L L N L D G K LC+ L P CKLQ L+L +C LTS CC DL+++L++S SL++L
Sbjct: 802 HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 861
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
L N+L D+GV + CE L+ +C L LGL + + E + L L++EKP+L +
Sbjct: 862 LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 916
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 443 bits (1140), Expect = e-124
Identities = 280/706 (39%), Positives = 389/706 (55%), Gaps = 44/706 (6%)
Query: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370
I++ LF P + EP V+ QGAAGIGK+ LAR++ W G LY DRF ++FY CR
Sbjct: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
Query: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430
E++ SL +LI PI +I+ +P R+LF++DG DE E LC W
Sbjct: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
Query: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
+ + D LL SL+ K +LPEAS LIT R AL+ L L+ R VE+LGFSE+ RKEYF
Sbjct: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
Query: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
++YF+DE QA AF L++ N+ L+ +C +P V W+ CT L QQM+ + L TSKTTT +
Sbjct: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
Query: 551 CLHYLAQALQAQ------PLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604
+ +L+ LQ + L L LCSLAA+GIW +K LF DLR HGL A +S F
Sbjct: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
Query: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657
L+M + Q E YSFIH+ FQEFFAAM Y+LE+EK GR + D+ L
Sbjct: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
Query: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWV----PSLQLL 710
E YG + RFL GL++ E +E C++SQ L++W+ + +L
Sbjct: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
Query: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL- 769
+QP LE +CLYE + + F+ + M +F ++ + + T M+ +V +FCI+ V+ L L
Sbjct: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
Query: 770 -------------IEGRQ--------HRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTR 808
EGR S+ + L R + + I VL +
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL-VLSSNQ 741
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
L ELDLS N+L ++ LC L+ C L+ L L C LT+ C+DLA L + +LT
Sbjct: 742 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 801
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
L + N L D+G LC++ + P C LQ+L LV+ GLTS CC L+SVLS + +L L
Sbjct: 802 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 861
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
L+ N L D G++LLCEGL HP CKL L LD L+ +L L
Sbjct: 862 LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
Score = 148 bits (374), Expect = 3e-35
Identities = 81/192 (42%), Positives = 114/192 (59%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A Q L SVL + +L L + N+L S V LC+ + P+C L+ L L GLT+
Sbjct: 782 LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 841
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ L NQ LT L L N L D G K LC+ L P CKLQ L+L +C LTS CC
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
DL+++L++S SL++L L N+L D+GV + CE L+ +C L LGL + + E + L
Sbjct: 902 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
Query: 972 RALEQEKPQLLI 983
L++EKP+L +
Sbjct: 962 ETLQEEKPELTV 973
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 8 RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67
+LA YLE L+ +LK+F++ L + + Q EK +++A+ ++ GE++AW
Sbjct: 9 KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 68 DLALHTWEQMGLRSLCAQAQ 87
+A+ + + R L +A+
Sbjct: 69 AMAVWIFAAINRRDLYEKAK 88
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 427 bits (1097), Expect = e-119
Identities = 257/656 (39%), Positives = 372/656 (56%), Gaps = 17/656 (2%)
Query: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
Query: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
Query: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
Query: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
Query: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
Query: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Query: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
Query: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
Query: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
Query: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
Query: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL L+ L++
Sbjct: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
Score = 134 bits (338), Expect = 5e-31
Identities = 79/186 (42%), Positives = 102/186 (54%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
L + L +++L QN L G+ L + L+ P CKL LGL + +E ++ L A+
Sbjct: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
Query: 978 KPQLLI 983
P L+I
Sbjct: 1070 NPHLII 1075
Score = 132 bits (332), Expect = 2e-30
Identities = 74/180 (41%), Positives = 105/180 (58%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLGL+ L+ Q+L
Sbjct: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDL 1006
Score = 114 bits (284), Expect = 8e-25
Identities = 69/175 (39%), Positives = 97/175 (55%)
Query: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
LDL N L D GV+LLC+ RHP+C L L L L++ +L ++ P L
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
Score = 78.6 bits (192), Expect = 4e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
Query: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
+ L +V ++P L + D +N +DV
Sbjct: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
Score = 45.1 bits (105), Expect = 5e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
Query: 68 DLALHTWEQMGLRSLCAQAQE 88
++L + +M L+ LC +A+E
Sbjct: 73 SVSLKIFGKMNLKDLCERAKE 93
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 341 bits (874), Expect = 3e-93
Identities = 238/761 (31%), Positives = 359/761 (47%), Gaps = 100/761 (13%)
Query: 299 SWP-DYV---EENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRG 354
SWP D+V ++ E++ L P + + ++L G AG+GK+TLA Q W G
Sbjct: 196 SWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANG 255
Query: 355 QLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE 414
L+ RF +VFY SC ++ K + AELI D API + +S+PE+LLFI+DG +E
Sbjct: 256 VLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEE 315
Query: 415 PGWVLQEPSSEL------CLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIP 468
++ E SE C W Q P +L SLL K ++P A+ LIT +T +++L
Sbjct: 316 --IIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
Query: 469 SLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACT 528
SL +V++ GF+ + YF R+F D + + + ++ N+ L+ C P V W C+
Sbjct: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
Query: 529 CLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLG-------PQLRDLCSLAAEGIWQ 581
CL Q R L ++TTT+L ++ + + Q R LCSLA EG+W
Sbjct: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWS 493
Query: 582 KKTLFSPDDLRKHGLDGAIISTFLKMGILQE-HPIPLSYSFIHLCFQEFFAAMSYVLEDE 640
F+ +D GL+ I + + ILQ+ + +F HL FQEFFAAMS+VLE+
Sbjct: 494 MNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEP 553
Query: 641 KGRGKHSNCIIDLEKTLEAYGI-HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG-- 697
+ HS +++ L+ + + F GLL+ RE+E+ HC++S
Sbjct: 554 REFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVM 613
Query: 698 RNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLV 753
L++W L LQ H L HCL+E++ + F +++ E+ + + D EL
Sbjct: 614 EELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQA 673
Query: 754 CTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDA--------YWQILFSVLK 805
+FC+K + + KL+L S + +L R + + + W + S L
Sbjct: 674 SSFCLKHCKRLNKLRL----------SVSSHILERDLEILETSKFDSRMHAWNSICSTLV 723
Query: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---------------------------- 837
NL ELDLS + L S+VK LC L+ PRC
Sbjct: 724 TNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSK 783
Query: 838 -----------------LLETLRLAGC----------GLTAEDCKDLAFGLRANQTLTEL 870
+L+ LR + C L+A C+DLA L + Q +T L
Sbjct: 784 LTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRL 843
Query: 871 DLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
L FN L D G K LC L P C L+RL+L C L + C+ L+ L + SL L+L
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903
Query: 931 QNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+N+L D GV+ LCE L P L L L + + E EL
Sbjct: 904 KNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGEL 944
Score = 122 bits (306), Expect = 2e-27
Identities = 72/158 (45%), Positives = 91/158 (57%), Gaps = 1/158 (0%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L L R+L L+LS NSL VK LC+ L RP L++L L+GC T E C +LA
Sbjct: 887 LSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELAN 946
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N + LDL N L D G K LC+ L+ P L L L C LT+ CCQ L SVLS
Sbjct: 947 ALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLS 1005
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
+S SL L+L N LD GV++LC+ L+ C+L +LG
Sbjct: 1006 SSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 116 bits (291), Expect = 1e-25
Identities = 74/172 (43%), Positives = 95/172 (55%), Gaps = 5/172 (2%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L S+ VTR L L N L +K LC L P+C LE L L C L A CK L+
Sbjct: 834 LTSIQHVTR----LCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSD 889
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N++LT L+LS N L D G K LC+ L +P LQ L L C T + C +LA+ LS
Sbjct: 890 ALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALS 949
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ ++K LDL +N+L D GV+LLCE L+ P L LGL + L+ Q L
Sbjct: 950 HNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHL 1000
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/51 (45%), Positives = 31/51 (60%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETL 842
+T A Q LFSVL +++L L+L GN L VK LCK L++ C L+ L
Sbjct: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 35.4 bits (80), Expect = 0.38
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 914 LASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRA 973
+ S L + +L ELDL + L V+ LC L++P CK+ +L T ++ + A
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
Query: 974 LE-QEKPQLLIFSRRKPSVMTP 994
L+ K L FS K + P
Sbjct: 778 LQGNSKLTHLNFSSNKLGMTVP 799
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 339 bits (869), Expect = 1e-92
Identities = 257/846 (30%), Positives = 395/846 (46%), Gaps = 107/846 (12%)
Query: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
Query: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
Query: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
Query: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
Query: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
Query: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
Query: 561 A--QPLGP-----QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
A Q P +L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
Query: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
Query: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
Query: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
Query: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
I ++ S P++ +L R +
Sbjct: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
Query: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
Query: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
Query: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMR 968
C ++ VL S SL LDL N L+D GV LC L+HP C + L L L+ +
Sbjct: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845
Query: 969 QELRAL 974
+++ A+
Sbjct: 846 KDIAAV 851
Score = 136 bits (342), Expect = 2e-31
Identities = 73/181 (40%), Positives = 104/181 (57%)
Query: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
Query: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
Query: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
+L+ L+L LD V +LCE L HP C L LGL ++ +E ++ L ++E++ P L
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
Query: 983 I 983
I
Sbjct: 974 I 974
Score = 124 bits (310), Expect = 8e-28
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
Query: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
LK L L N + D GVR LC L+HP CKL LGL
Sbjct: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
Score = 69.7 bits (169), Expect = 2e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
Query: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
Query: 922 PSL 924
P L
Sbjct: 970 PHL 972
Score = 38.9 bits (89), Expect = 0.034
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
Query: 69 LALHTWEQMGLRSLCAQAQE 88
+ L+ + Q+ + L +AQE
Sbjct: 71 VTLNLFLQINRKDLWTKAQE 90
Score = 34.3 bits (77), Expect = 0.85
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
Query: 851 AEDCKDL 857
E K L
Sbjct: 956 EETQKIL 962
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 333 bits (853), Expect = 9e-91
Identities = 240/726 (33%), Positives = 365/726 (50%), Gaps = 79/726 (10%)
Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
V+L G AG+GK+TLA+++ W L +F++ FY SCREL++ S AEL+ +D
Sbjct: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWP 267
Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
I IL++ ++LF++DG DE G ++C W + +P LLGSLL + +L
Sbjct: 268 ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVML 327
Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
P+A+ L+T R AL++L E+ ++ V GF E R+ YF R+F DE QA+RAF L++S
Sbjct: 328 PKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRS 387
Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL-QAQPLGPQL 568
N L+ L P V W+ CT L QM++ E T T T L L +L Q L L
Sbjct: 388 NAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGAL 447
Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLS-YSFIHLCFQ 627
R L LAA+G+W + ++ +DL + G+ + + FL IL++ + YSFIHL FQ
Sbjct: 448 RTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQ 507
Query: 628 EFFAAMSYVL--EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTR---FLLGLLSDEG 682
+F A+ Y L E+E+ R H+ I D++K L G+ L + + GL +++
Sbjct: 508 QFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS--GVERLRNPDLIQAGYYSFGLANEKR 565
Query: 683 EREMENIFHCRLSQGRNLMQWVPSLQLLLQ-PHSL-----ESLHCLYETRNKTFLTQVMA 736
+E+E F CR+S ++ Q + + + HS E L CLYE++ + + +VMA
Sbjct: 566 AKELEATFGCRMSP--DIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMA 623
Query: 737 HFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL---IEGRQHRSTWSPTMVVLFRWVPVT 793
F+E+ + + ++++ +FC+K R+++K+ L E T S + + R
Sbjct: 624 QFKEISLHLNA-VDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQ 682
Query: 794 D--AYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC-------------- 837
+W L S+ ++L L ++ + LS S V+ LC+ + C
Sbjct: 683 HMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPAD 742
Query: 838 -------------------------------LLETLR----------LAGCGLTAEDCKD 856
L E LR L C T + D
Sbjct: 743 AHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWAD 802
Query: 857 LAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLAS 916
L+ L NQ+LT ++LS N L D GAK L LR P C LQRL L +C LT C+DLA+
Sbjct: 803 LSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAA 862
Query: 917 VLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQ 976
VL S L L L +N + + GV+ LCEGLR+P CKL L L ++ + +L L Q
Sbjct: 863 VLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQ 922
Query: 977 EKPQLL 982
EK LL
Sbjct: 923 EKSSLL 928
Score = 126 bits (316), Expect = 2e-28
Identities = 76/192 (39%), Positives = 109/192 (56%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V+R L L L+ N + ++ VK LC+ LR P C L+TL L C +T+
Sbjct: 852 LTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITS 911
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL L+ +L LDL N + G K LC+ LR+P C L+ L L C + C
Sbjct: 912 DGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSC 971
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+DL S LS + SL LDL QN L GV++L E L + L L L +DE+ + L
Sbjct: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLL 1031
Query: 972 RALEQEKPQLLI 983
+E++ PQL+I
Sbjct: 1032 EEIEEKNPQLII 1043
Score = 125 bits (313), Expect = 4e-28
Identities = 70/161 (43%), Positives = 91/161 (56%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W L L+V ++L ++LS N L K L TLR P+C L+ L L C LT
Sbjct: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
+CKDLA L ++ LT L L+ N + + G K LC+ LR P CKLQ L L +C +TSD C
Sbjct: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
DL +L SL LDL N++ G++ LCE LR P C L
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNL 956
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 330 bits (846), Expect = 6e-90
Identities = 246/713 (34%), Positives = 361/713 (50%), Gaps = 75/713 (10%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 ----------------------IEGRQH---------------RSTWSPTMVVLFRWVPV 792
+E +Q RST V + P
Sbjct: 630 LENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPD 689
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 690 T-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATP 747
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT C
Sbjct: 748 EQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASC 807
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
+DLA+VL S L L L +N + D GV+ LCEGL +P CKL L L Q +++
Sbjct: 808 KDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSIT 860
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 910
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 978
Query: 970 ELRALEQEKPQLLI 983
L ++++ P+L I
Sbjct: 979 LLEEVKEKNPKLTI 992
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 324 bits (830), Expect = 4e-88
Identities = 228/724 (31%), Positives = 359/724 (49%), Gaps = 100/724 (13%)
Query: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
Query: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
Query: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
Query: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
Query: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
Query: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
Query: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
Query: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
Query: 831 TLRRPRCLLETLRLAGCGLTAE------------DCKDLAFGLRA--------------- 863
LR P C L+ L + + + D K L+F L
Sbjct: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720
Query: 864 -----------------------------NQTLTELDLSFNVLTDAGAKHLCQRLRQPSC 894
N+ LT L++S N L D G LC+ L P
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDT 779
Query: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLI 954
L L L C L+ CC+ ++ +L + S++ LDL N L D G++ LCE L+HP C L
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLD 839
Query: 955 RLGL 958
L L
Sbjct: 840 SLCL 843
Score = 153 bits (386), Expect = 1e-36
Identities = 80/186 (43%), Positives = 113/186 (60%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
L+ S +L++L+L N LD GV +LCE LRHP C L LGL +T +E + L A E+
Sbjct: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEER 976
Query: 978 KPQLLI 983
P L I
Sbjct: 977 NPNLTI 982
Score = 115 bits (287), Expect = 4e-25
Identities = 68/177 (38%), Positives = 104/177 (58%), Gaps = 1/177 (0%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
L ++ +LK L + N + DVGV+LLC L H C+L LGL++ L+ ++L ++
Sbjct: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
Query: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
+ L +++M + LC + +E G++ ++
Sbjct: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
Query: 860 GLRANQTLTELD 871
N LT D
Sbjct: 973 EEERNPNLTITD 984
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 322 bits (826), Expect = 1e-87
Identities = 210/660 (31%), Positives = 341/660 (51%), Gaps = 34/660 (5%)
Query: 327 PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGK 386
PR V+L G +GIGKS LAR++ W +G LY F +VF+ RE+ + K S+ E I +
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISR 338
Query: 387 DGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGK 446
+ + AP+ +I+SRPERLLFI+DG D+ G VL ++LC W++ QP L+ SLL K
Sbjct: 339 EWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRK 397
Query: 447 TILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRL 506
+LPE+ ++T R + L + R++ V G S R E Q + R
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRA 457
Query: 507 VKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGP 566
+ +N+EL C VP V L C L Q E + ++T T L ++ L + +
Sbjct: 458 IMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVR 517
Query: 567 Q---------LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI-LQEHPIP 616
+ L+ C +A EG+W +K++F DDL GL + + M I L +
Sbjct: 518 RCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCE 577
Query: 617 LSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKT-----LEAYGIHGLFGASTT 671
Y+F HL Q+F AA+ YVLE + + + C + +EKT L+ G H +
Sbjct: 578 EYYTFFHLSLQDFCAALYYVLEGLE--IEPALCPLYVEKTKRSMELKQAGFH-IHSLWMK 634
Query: 672 RFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPH------SLESLHCLY 723
RFL GL+S++ R +E + C + G + L+ WV L QP+ +L++ HCL+
Sbjct: 635 RFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLG--QQPNATTPGDTLDAFHCLF 692
Query: 724 ETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL----IEGRQHRSTW 779
ET++K F+ + F+E+ + + +++L+ +FC++ +++K+++ I R +
Sbjct: 693 ETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEA 752
Query: 780 SPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLL 839
P + + R + + W+ S+L +L++LDL + L+ A+K+LC LR P C +
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
Query: 840 ETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRL 899
+TL +T + L + AN+ L L+L L + + C+ L+ P C L+ L
Sbjct: 813 QTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLD 959
+L CGLT C ++ +L+ SPSLK L L N + D GV L + LR C L +L L+
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
Score = 139 bits (351), Expect = 1e-32
Identities = 80/180 (44%), Positives = 100/180 (55%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T Q L S L R+L L LS NSL + V LC+++R P C L+ L L C L
Sbjct: 935 ITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDT 994
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C LA L N LT L LS N + D G K LC+ +R+PSC LQ L+LV C LT+ CC
Sbjct: 995 AGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACC 1054
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ L+ V+S S LK LDL N L D GV LCEGL+ L RLGL L+ + + L
Sbjct: 1055 ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEAL 1114
Score = 116 bits (290), Expect = 2e-25
Identities = 66/174 (37%), Positives = 96/174 (55%)
Query: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
L L LS N + + VK LC+ +R P C L+ L L C LTA C+ L+ + ++ L
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
Query: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
LDL+ N L D G LC+ L+Q + L RL L +CGLTSDCC+ L+ LS + L L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
Query: 930 QQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
QNN G+ LC P L +GL + ++R+ L ++ KP+++I
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
Score = 115 bits (289), Expect = 2e-25
Identities = 67/167 (40%), Positives = 93/167 (55%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + + +L + +LK L L+GN ++ V L LR +C L+ L L CG+TA
Sbjct: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA L +N++LT L LS N L + G LC+ +R P C LQRL L C L + C
Sbjct: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
LA L + L L L N ++D GV+LLCE +R P+C L L L
Sbjct: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Score = 68.2 bits (165), Expect = 5e-11
Identities = 39/110 (35%), Positives = 60/110 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A + L V+ +R+LK LDL+ N+L V +LC+ L++ +L L L CGLT+
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
+ C+ L+ L N+ LT L+L N + G LC P+ LQ + L
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
Score = 39.3 bits (90), Expect = 0.026
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 5 AWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQ-YGE 63
++G C E L KEE + F+ LL K+ S S++ P + + +E + L+ + YG
Sbjct: 62 SYGLQWCLYE-LDKEEFQTFKELLKKKS-SESTTCSIPQFEIENANVECLALLLHEYYGA 119
Query: 64 QRAWDLALHTWEQMGLRSLCAQAQEG-AGHSPSFP 97
AW ++ +E M LR+L +A++ HSP P
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDP 154
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 319 bits (818), Expect = 1e-86
Identities = 247/740 (33%), Positives = 363/740 (49%), Gaps = 101/740 (13%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
++ R T+ T+ R + W S+ NLK L++ + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688
Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
S+V+ LC + R C L+ L LAG
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748
Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
C L T E + + L+ANQ+L L LS NVL D GA
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 945 GLRHPACKLIRLGLDQTTLS 964
GL +P CKL L L Q +++
Sbjct: 869 GLSYPDCKLQTLVLQQCSIT 888
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 938
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 1006
Query: 970 ELRALEQEKPQLLI 983
L ++++ P+L I
Sbjct: 1007 LLEEVKEKNPKLTI 1020
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 319 bits (818), Expect = 1e-86
Identities = 247/740 (33%), Positives = 363/740 (49%), Gaps = 101/740 (13%)
Query: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
Query: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
Query: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
Query: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
Query: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
Query: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQL---LLQPHSL 716
L + FL GL +++ +E+E F CR+S + L+Q L L
Sbjct: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------- 769
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 570 EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF 629
Query: 770 --------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLS 821
++ R T+ T+ R + W S+ NLK L++ + LS
Sbjct: 630 LENYMDFELDIEFERCTYL-TIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLS 688
Query: 822 HSAVKSLCKTLRRPRCLLET---------------------------LRLAG-------- 846
S+V+ LC + R C L+ L LAG
Sbjct: 689 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 748
Query: 847 ------------CGL----------TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKH 884
C L T E + + L+ANQ+L L LS NVL D GA
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
Query: 885 LCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 945 GLRHPACKLIRLGLDQTTLS 964
GL +P CKL L L Q +++
Sbjct: 869 GLSYPDCKLQTLVLQQCSIT 888
Score = 120 bits (302), Expect = 7e-27
Identities = 73/191 (38%), Positives = 101/191 (52%), Gaps = 1/191 (0%)
Query: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
Query: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
Query: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
L+ L + SL LDL N + G+ +LC+ L +P C L L L + E+++ L
Sbjct: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLE 952
Query: 973 ALEQEKPQLLI 983
++++ P+L I
Sbjct: 953 EVKEKNPKLTI 963
Score = 72.4 bits (176), Expect = 3e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
Query: 912 QDLASVLSASPSL 924
+ L V +P L
Sbjct: 949 KLLEEVKEKNPKL 961
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 314 bits (805), Expect = 3e-85
Identities = 248/760 (32%), Positives = 369/760 (48%), Gaps = 83/760 (10%)
Query: 276 QKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGA 335
++FT+LL+ ++ L P+ R LF + + P V+LQG
Sbjct: 145 KRFTKLLIAPES-AAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVVLQGP 203
Query: 336 AGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVV-SLAELIGKDGTATPAP 394
AGIGK+ A+++ W G+LY + F+ C EL + SLA+LI AP
Sbjct: 204 AGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAP 263
Query: 395 IRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASF 454
+ Q+L++P+RLLFILDG DE L P + C + +LG LL K +LP A
Sbjct: 264 VPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKALLPTALL 322
Query: 455 LITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELW 514
L+T R A L L + EV GFS+ +K+YFY++F DER+A RA+R VK N+ L+
Sbjct: 323 LVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLF 382
Query: 515 ALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPL--GPQL---- 568
ALC VP+V W+ CT L QQ++ L+ TSKTTT++ L ++ L + P+ GP+L
Sbjct: 383 ALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDL 442
Query: 569 RDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST-FLKM----GILQEHPIPLSYSFIH 623
R+LC LA EG+ ++ F+ +L + L G+ + T FL G+L+ ++Y FI
Sbjct: 443 RNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE---VTYQFID 499
Query: 624 LCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGE 683
FQEF AA+SY+LED + + L + H + TTRFL GLLS E
Sbjct: 500 QSFQEFLAALSYLLEDGGVPRTAAGGVGTLLRGDAQPHSHLVL---TTRFLFGLLSAERM 556
Query: 684 REMENIFHCRLSQ--GRNLMQWV------------------PSLQLLLQP---------- 713
R++E F C +S+ + ++WV L+ +P
Sbjct: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
Query: 714 HSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKKLQLIE 771
+ LE L+CLYET+ F+ Q + F E+ + M++ V ++C++ + L+LI
Sbjct: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
Query: 772 GRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
R V + + L L+ + L G S S K L +
Sbjct: 677 ---------------CRLVAAQEKKKKSLGKRLQAS-------LGGGSSSQGTTKQLPAS 714
Query: 832 LRR--------PRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
L P C L +L L+ C L C+DL+ LRA LTEL L N L++AG +
Sbjct: 715 LLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLR 774
Query: 884 HLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLC 943
L + L P C++Q ++ V Q L +L SP+L LDL L V LC
Sbjct: 775 MLSEGLAWPQCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLC 833
Query: 944 EGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLI 983
L+H C L L L LS++ QEL+A+++ KP L+I
Sbjct: 834 AVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 281 bits (720), Expect = 2e-75
Identities = 202/686 (29%), Positives = 335/686 (48%), Gaps = 51/686 (7%)
Query: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
Query: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
Query: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
Query: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
Query: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
Query: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
Query: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
Query: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
Query: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
Query: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
Query: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
C+LQ L+L C T DL + L + LK L L++N+L++ G L +L
Sbjct: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQL 841
Query: 954 IRLGLDQTTLSDEMRQELRA-LEQEK 978
RL ++ L+ + L + L Q K
Sbjct: 842 ERLSIENCNLTQLTCESLASCLRQSK 867
Score = 112 bits (279), Expect = 3e-24
Identities = 77/235 (32%), Positives = 104/235 (44%), Gaps = 51/235 (21%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLA------------ 845
Q L VL ++L+ L++ + AVK LC+ LR PRC L+ LRL
Sbjct: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
Query: 846 ---------------------------------------GCGLTAEDCKDLAFGLRANQT 866
C LT C+ LA LR ++
Sbjct: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868
Query: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
LT L L+ N L D GAKH+ L C LQRL L C LT +CCQD+ S L + +LK
Sbjct: 869 LTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKS 928
Query: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
LDL N+L D GV LLCE L++P C L L L+ + Q + ++ ++ L
Sbjct: 929 LDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
Score = 108 bits (269), Expect = 5e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Score = 69.7 bits (169), Expect = 2e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
Query: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
Query: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
Query: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
N + G LC+ S + +R +++ C
Sbjct: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
Score = 57.4 bits (137), Expect = 9e-08
Identities = 44/137 (32%), Positives = 63/137 (45%), Gaps = 1/137 (0%)
Query: 855 KDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDL 914
+DL N L L ++ +VL K L LR P CKLQ+L L T QDL
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTM-LNQDL 751
Query: 915 ASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
VL+ + L+ L++Q ++ V+LLC LR P C+L L L+ + + +L
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
Query: 975 EQEKPQLLIFSRRKPSV 991
Q L RK S+
Sbjct: 812 LQGNGHLKTLILRKNSL 828
Score = 33.9 bits (76), Expect = 1.1
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Query: 69 LALHTWEQMGLRSLC 83
+ + + M +C
Sbjct: 100 VTSNIFAIMNCDKMC 114
>gi|7662404 caspase recruitment domain family, member 8 [Homo sapiens]
Length = 431
Score = 271 bits (694), Expect = 2e-72
Identities = 140/276 (50%), Positives = 183/276 (66%), Gaps = 5/276 (1%)
Query: 1083 FWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLG- 1141
F GP G V E++DK N Y V FP AG Y W TGL F++R+ VTV I F W Q L
Sbjct: 56 FLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLAL 115
Query: 1142 EINPQHSWMVAGPLLDIKAEPG-AVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEK 1200
++ W+V GPL D+ AEP AV +HLPHF++LQG VD S F +AHFK EGM+LE
Sbjct: 116 DLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQG-EVDVSWFLVAHFKNEGMVLEH 174
Query: 1201 PARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSD 1260
PARVE + VLE+PSFS +G+LL++ IP+TS L+Y+ HPE++ FHLYL+PSD
Sbjct: 175 PARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSD 234
Query: 1261 CSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGE 1320
+ KAIDD E +F VR+ PP+ PL G Y VS S + L+++PKEL+L YRSPGE
Sbjct: 235 ALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSAN--LKVMPKELKLSYRSPGE 292
Query: 1321 DQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKP 1356
Q FS+FY G + I+L++ +K+ TLVW+ VKP
Sbjct: 293 IQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKP 328
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 252 bits (643), Expect = 2e-66
Identities = 176/493 (35%), Positives = 261/493 (52%), Gaps = 26/493 (5%)
Query: 253 HPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLI 312
H + RE + W+ N ++ Q+LL+ +P S + L +P+ E+ +
Sbjct: 96 HDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLAC-PFPEQELES----V 150
Query: 313 EIRDLFGPG-LDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRE 371
+ LF G + P +V+LQG+AG GK+TLAR++ W G LY RF +VFY SC+E
Sbjct: 151 TVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKE 210
Query: 372 LAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWS 431
+ L +L+ AP+ +IL +PERLLFILDG DE LQ P E L
Sbjct: 211 VVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDE----LQRPFEEK-LKKR 265
Query: 432 QPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFY 491
P ++LL L+ + LP S LIT R AL+NL P L+QAR V +LGFSE R YF
Sbjct: 266 GLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFS 325
Query: 492 RYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLC 551
YFTDE+QA RAF +V+ N L+ C VP + W+ C+ L QM+R + + T + +T +
Sbjct: 326 SYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIF 385
Query: 552 LHYLAQALQAQPLG--------PQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIIST 603
+ Y++ L G LR LCSLAAEGI ++ LF +LRKH LDG ++
Sbjct: 386 MAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAA 445
Query: 604 FLKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGR-GKHSNCIIDLEKTLEAYG 661
FL Q I YSF H+ FQ+FF AMSY++++++ R GK S ++++ LE
Sbjct: 446 FLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESR--REVQRLLEVKE 503
Query: 662 IHGLFGAS-TTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPHSLES 718
G + T +FLL + + +E F R+S ++L + ++ + + +
Sbjct: 504 QEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDL 563
Query: 719 LHCLYETRNKTFL 731
LYE + K +
Sbjct: 564 EFSLYEAKIKNLV 576
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 250 bits (639), Expect = 6e-66
Identities = 192/652 (29%), Positives = 310/652 (47%), Gaps = 41/652 (6%)
Query: 330 VILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGT 389
V L G GK+ + W +G+++ + +V + + E+ Q SLAELI KD
Sbjct: 149 VFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWP 208
Query: 390 ATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTIL 449
API ILS P++LLFIL+ +D + L S LC + +Q P LL SLL + +
Sbjct: 209 DGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMA 268
Query: 450 PEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKS 509
P FLI++R T N+ L++ L S R+ YF +F D ++A A +LV
Sbjct: 269 PGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHE 328
Query: 510 NKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQP------ 563
++ L LC V + W+ CT L +QM + L +T T L H+LA AL ++
Sbjct: 329 DEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQ 388
Query: 564 --LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL-QEHPIPLSYS 620
LG L+ LC LAA G++ FS +DLR G A +S IL + Y
Sbjct: 389 YHLG-LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYK 447
Query: 621 FIHLCFQEFFAAMSYVLEDEK-----GRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLL 675
FIHL QEF A+++++ G ++ EK + + +F F+
Sbjct: 448 FIHLNVQEFCTAIAFLMAVPNYLIPSGSREYK------EKREQYSDFNQVF-----TFIF 496
Query: 676 GLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQ------PHSLESLHCLYETRNKT 729
GLL+ + +E F +L + + L H + +CLYE R +
Sbjct: 497 GLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEE 556
Query: 730 FLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGR---QHRSTWSPTMVVL 786
F+ ++ E+ + +++D +++V +C+ + H++ L+L R PT +
Sbjct: 557 FVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQM 616
Query: 787 FRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAG 846
V YW+ + S+ +L+EL + N L+ + + L K L C L TL+L+
Sbjct: 617 KSLV-----YWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSY 671
Query: 847 CGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGL 906
TA +DL L N++LT L ++ ++ L L +P+C++ L L+ C L
Sbjct: 672 VS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDL 730
Query: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
+ C+++AS+L + SL++L L N L G+ +LC+ L HP C LI L L
Sbjct: 731 RASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782
Score = 123 bits (309), Expect = 1e-27
Identities = 72/194 (37%), Positives = 109/194 (56%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+ L VL + L++LDL N L + V + L P C LE L L+GC ++
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C+ +A + N+ L L++ N + DAG + LC LR P+C L + L C LTS CC
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ LASVL+ + +L+ L+L QN+L + GV L E L P C L +GL T L+ + +Q L
Sbjct: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
Query: 972 RALEQEKPQLLIFS 985
+++ KP L+ S
Sbjct: 967 MTVKERKPSLIFLS 980
Score = 115 bits (289), Expect = 2e-25
Identities = 61/166 (36%), Positives = 93/166 (56%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+L++L LS N L + LC L P C L +L L C LT C L L + TL
Sbjct: 747 SLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLR 806
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
+LDL N L + G H+ L P+C+L+ L L C +SD CQ +A V++ + L+ L+
Sbjct: 807 QLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLE 866
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
+ N ++D G++LLC GLRHP C L+ +GL++ L+ + L ++
Sbjct: 867 IGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASV 912
Score = 38.9 bits (89), Expect = 0.034
Identities = 19/67 (28%), Positives = 36/67 (53%)
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+++ S+ SL+EL + N+L+ + R+L + L H +CKL L L + + L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
Query: 972 RALEQEK 978
+AL + +
Sbjct: 683 KALARNR 689
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 151 bits (381), Expect = 5e-36
Identities = 88/184 (47%), Positives = 108/184 (58%)
Query: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Query: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
Query: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
L + +L +L L N L D GVRLLC+ L HP CKL L L L+ L AL
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
Query: 978 KPQL 981
KP L
Sbjct: 280 KPYL 283
Score = 148 bits (374), Expect = 3e-35
Identities = 79/172 (45%), Positives = 105/172 (61%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ SL+ELDL N L D+GV LLCEGLRHP CKL L LD L+ + + L
Sbjct: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216
Score = 116 bits (290), Expect = 2e-25
Identities = 66/153 (43%), Positives = 92/153 (60%), Gaps = 2/153 (1%)
Query: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
Query: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
Query: 939 VRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+RLLC+GLRHP C+L L L L+ EL
Sbjct: 127 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Score = 103 bits (257), Expect = 1e-21
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
Query: 912 QDLASVLSASPSL 924
LA++ P L
Sbjct: 271 SRLAALRVTKPYL 283
Score = 65.5 bits (158), Expect = 3e-10
Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH 948
L QP + QRL L C ++S C+DL++ L A+ +L +DL N + G+ LLCEGLRH
Sbjct: 22 LLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRH 79
Query: 949 PACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
P C+L + L + L QE+ ++ P L+
Sbjct: 80 PQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 113
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 141 bits (355), Expect = 5e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
Query: 980 QLLIFS 985
L + S
Sbjct: 456 SLRVIS 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (325), Expect = 1e-29
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 972 RALEQEKPQL 981
+ K L
Sbjct: 220 CGIVASKASL 229
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 122 bits (305), Expect = 3e-27
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 972 RA 973
A
Sbjct: 391 AA 392
Score = 115 bits (289), Expect = 2e-25
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 141 bits (355), Expect = 5e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
Query: 980 QLLIFS 985
L + S
Sbjct: 456 SLRVIS 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (325), Expect = 1e-29
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 972 RALEQEKPQL 981
+ K L
Sbjct: 220 CGIVASKASL 229
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 122 bits (305), Expect = 3e-27
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 972 RA 973
A
Sbjct: 391 AA 392
Score = 115 bits (289), Expect = 2e-25
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 141 bits (355), Expect = 5e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
Query: 980 QLLIFS 985
L + S
Sbjct: 456 SLRVIS 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (325), Expect = 1e-29
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 972 RALEQEKPQL 981
+ K L
Sbjct: 220 CGIVASKASL 229
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 122 bits (305), Expect = 3e-27
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 972 RA 973
A
Sbjct: 391 AA 392
Score = 115 bits (289), Expect = 2e-25
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 141 bits (355), Expect = 5e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
Query: 980 QLLIFS 985
L + S
Sbjct: 456 SLRVIS 461
Score = 130 bits (328), Expect = 7e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
Score = 129 bits (325), Expect = 1e-29
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 972 RALEQEKPQL 981
+ K L
Sbjct: 220 CGIVASKASL 229
Score = 126 bits (316), Expect = 2e-28
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
Query: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Score = 122 bits (305), Expect = 3e-27
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
Query: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
Query: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
Query: 972 RA 973
A
Sbjct: 391 AA 392
Score = 115 bits (289), Expect = 2e-25
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
Query: 838 LLETLRL 844
LLE L L
Sbjct: 428 LLEQLVL 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,585,135
Number of Sequences: 37866
Number of extensions: 2946556
Number of successful extensions: 10052
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 9215
Number of HSP's gapped (non-prelim): 606
length of query: 1375
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1260
effective length of database: 13,892,928
effective search space: 17505089280
effective search space used: 17505089280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.