Search of human proteins with 71274186

Search of human proteins with 71274186

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
         (1200 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71274186 hypothetical protein LOC85449 [Homo sapiens]             2413   0.0  
gi|50843837 hypothetical protein LOC55701 [Homo sapiens]              260   6e-69
gi|193211598 pleckstrin homology domain containing, family G (wi...   187   7e-47
gi|193211596 pleckstrin homology domain containing, family G (wi...   187   7e-47
gi|193211594 pleckstrin homology domain containing, family G (wi...   187   7e-47
gi|55742734 pleckstrin homology domain containing, family G (wit...   187   7e-47
gi|193211603 pleckstrin homology domain containing, family G (wi...   182   1e-45
gi|148529025 pleckstrin homology domain containing, family G (wi...   179   1e-44
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    84   6e-16
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    84   6e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    70   2e-11
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           69   3e-11
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             69   3e-11
gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]               61   7e-09
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    59   2e-08
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ...    56   2e-07
gi|91208420 bassoon protein [Homo sapiens]                             54   1e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         52   3e-06
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  52   4e-06
gi|41281612 zinc finger protein 828 [Homo sapiens]                     49   2e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    46   2e-04
gi|38787970 tensin like C1 domain containing phosphatase isoform...    46   2e-04
gi|38787957 tensin like C1 domain containing phosphatase isoform...    46   2e-04
gi|38787941 tensin like C1 domain containing phosphatase isoform...    46   2e-04
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    46   2e-04
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    45   5e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        45   5e-04
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       44   7e-04
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       44   7e-04
gi|55741655 anoctamin 8 [Homo sapiens]                                 44   0.001

>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
          Length = 1200

 Score = 2413 bits (6253), Expect = 0.0
 Identities = 1200/1200 (100%), Positives = 1200/1200 (100%)

Query: 1    MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCE 60
            MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCE
Sbjct: 1    MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCE 60

Query: 61   QVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIM 120
            QVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIM
Sbjct: 61   QVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIM 120

Query: 121  IKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTK 180
            IKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTK
Sbjct: 121  IKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTK 180

Query: 181  ITSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRT 240
            ITSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRT
Sbjct: 181  ITSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRT 240

Query: 241  YGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGC 300
            YGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGC
Sbjct: 241  YGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGC 300

Query: 301  TSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKA 360
            TSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKA
Sbjct: 301  TSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKA 360

Query: 361  PTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQA 420
            PTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQA
Sbjct: 361  PTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQA 420

Query: 421  SSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQR 480
            SSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQR
Sbjct: 421  SSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQR 480

Query: 481  QPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAA 540
            QPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAA
Sbjct: 481  QPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAA 540

Query: 541  LPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEG 600
            LPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEG
Sbjct: 541  LPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEG 600

Query: 601  AWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPA 660
            AWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPA
Sbjct: 601  AWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPA 660

Query: 661  SIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVH 720
            SIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVH
Sbjct: 661  SIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVH 720

Query: 721  FFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLG 780
            FFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLG
Sbjct: 721  FFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLG 780

Query: 781  LQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELR 840
            LQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELR
Sbjct: 781  LQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELR 840

Query: 841  VRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGL 900
            VRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGL
Sbjct: 841  VRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGL 900

Query: 901  ELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLH 960
            ELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLH
Sbjct: 901  ELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLH 960

Query: 961  LHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQ 1020
            LHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQ
Sbjct: 961  LHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQ 1020

Query: 1021 VASLSRAGLGQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGV 1080
            VASLSRAGLGQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGV
Sbjct: 1021 VASLSRAGLGQELWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGV 1080

Query: 1081 SVEVTSKGRWDQPPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGSPPQEAGQAAEAEDGK 1140
            SVEVTSKGRWDQPPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGSPPQEAGQAAEAEDGK
Sbjct: 1081 SVEVTSKGRWDQPPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGSPPQEAGQAAEAEDGK 1140

Query: 1141 GSHKLPDPAREHLLATTFFRQQPPRQSQVPRLTGGSFSSEGTDSQTSLEDSPQTSPLASL 1200
            GSHKLPDPAREHLLATTFFRQQPPRQSQVPRLTGGSFSSEGTDSQTSLEDSPQTSPLASL
Sbjct: 1141 GSHKLPDPAREHLLATTFFRQQPPRQSQVPRLTGGSFSSEGTDSQTSLEDSPQTSPLASL 1200


>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
          Length = 1519

 Score =  260 bits (664), Expect = 6e-69
 Identities = 279/947 (29%), Positives = 400/947 (42%), Gaps = 140/947 (14%)

Query: 1   MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCE 60
           M+P  ++  +Q  LA LYPPFEATAPT+LGQVF++++  ++ D L + LDFL+PAK L  
Sbjct: 1   MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 60

Query: 61  QVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIM 120
           +V++ ACA YS  LF HEGWPLCL ++VVV LA L   LLR GDFYLQV P   Q+  + 
Sbjct: 61  KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 120

Query: 121 IKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTK 180
           +KCL+     V + PVP  A   LFT EWL+ IN D     L  CL+++ +GI  +PW +
Sbjct: 121 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 180

Query: 181 ITSPEFVDDRPQVVNALCQAWGP-LPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGR 239
           +  P FV     +V        P LP     L SP             LP ++L      
Sbjct: 181 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPP------------LPEEAL------ 222

Query: 240 TYGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTS-- 297
             G++ PG                     +  EG+YV LL  +   RG SP+   G+   
Sbjct: 223 --GTRSPG--------------DGHNAPVEGPEGEYVELLEVTLPVRG-SPTDAEGSPGL 265

Query: 298 SGCTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVN 357
           S   +    + AG K      +   + +   GP   + A         RP   G     +
Sbjct: 266 SRVRTVPTRKGAGGKGRHRRHRAW-MHQKGLGPRGQDGA---------RPPGEGSSTGAS 315

Query: 358 LKAPTHNSERPPQGSYMNVLE---DALDCASG--------LRAGVSQEPAASKMQGPLGN 406
            ++P   +E  P+ + + V E   +A+  ASG        LR G      A   +GP G 
Sbjct: 316 PESPP-GAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGA---EGPPGT 371

Query: 407 PENMVQ-LRPGPRQASSPRLSPASPAAAASE-TKIEVKTKERNGRLPKPMPCPSRNTSSP 464
           P    +  R   R A    LS    +A  S   K +   +E  G LP P        S  
Sbjct: 372 PRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP--------SEH 423

Query: 465 EPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLG--KAGTTQT 522
           + P   L      G  +P   P           K L +    +P  +++ G  + G  + 
Sbjct: 424 KLPECHLVKEEYEGSGKPESEP-----------KELKTAGEKEPQLSEACGPTEEGAGER 472

Query: 523 KTSGPA-------TAP-SPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKV- 573
           +  GP        T P  PL++     P        +G  + EE         AL V V 
Sbjct: 473 ELEGPGLLCMAGHTGPEGPLSD--TPTPPLETVQEGKGDNIPEE---------ALAVSVS 521

Query: 574 ---------FRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPR 624
                      S    L GG D++GR LL + T     E P  +   +   L YL ++ R
Sbjct: 522 DHPDVAWDLMASGFLILTGGVDQSGRALLTI-TPPCPPEEPPPSRDTLNTTLHYLHSLLR 580

Query: 625 PEDKAKGLAVLIDARRQPP-QPGLVSAL-QATQAQVPASIRAILFLGEKEAALQLQTLPD 682
           P+ +  GL+VL+D R+ PP  P L+ AL Q   +  P  ++ +L L   +   +L     
Sbjct: 581 PDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQG 640

Query: 683 VQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQAS 742
            +V     LK ++    P +L   L G      + WV   Q++             ++ +
Sbjct: 641 AEVLSENDLKRVA---KPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQA 697

Query: 743 IEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFS 802
           IEE E A  P    E    +   K L + VL DP L  LQR+GGA L RL+        +
Sbjct: 698 IEELEGAAEP----EEEEAVGMPKPL-QKVLADPRLTALQRDGGAILMRLRS-------T 745

Query: 803 PDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGR 862
           P  +        LY  VDE +H LV  SN  + + E R  L RL+    QV  W+   G 
Sbjct: 746 PSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQ----QVLQWLSGPGE 801

Query: 863 RCLQSLTPKDGSLETVEKAHAEFENFFLQA---AAQYRRGLELSKQA 906
             L S      +L  +++    F  F  +     AQ R  L L + A
Sbjct: 802 EQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENA 848


>gi|193211598 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  187 bits (474), Expect = 7e-47
 Identities = 167/538 (31%), Positives = 244/538 (45%), Gaps = 52/538 (9%)

Query: 485 TPEKASLQHNGPW-----KVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEK 538
           T E +S+   GP       +LC + S            G       GP+ A PS L+   
Sbjct: 86  TVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGA 145

Query: 539 AALPEASAGSP--ERGPTLEEEPPG---PEPRIGALGV----KVFRSRIACLPGGRDRAG 589
                   G P  E    LE  P G   P+P    L      ++  S +A LPG RD  G
Sbjct: 146 LDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQG 205

Query: 590 RPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVS 649
           R +LL+     AW    C+  E+ +LL YL +IPRPE +A GL VL+DAR   P   L S
Sbjct: 206 RAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFS 265

Query: 650 ALQATQAQVPASIRAILFLG-----EKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLP 704
            L   Q   P ++  +L +G     E  + LQL+ LP          ++L  H+  + LP
Sbjct: 266 GLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS---------QSLLTHIPTAGLP 316

Query: 705 AVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSK 764
             L G  PYCH  W+ F ++L+  L +   A +LLQ +IE  +    P    E  + L +
Sbjct: 317 TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQ 376

Query: 765 SKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLH 824
           ++ LM+ VL  P L  LQ +GG  L  L+ +   +  SPD R+ +  A  LY  VD  LH
Sbjct: 377 TEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLH 436

Query: 825 VLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAE 884
            L   SN  +  LEL   L   E+ +HQ+  W++Q G   L+     + SL+ + +A   
Sbjct: 437 QLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEE--AGEPSLDMLLQAQGS 494

Query: 885 FENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF 944
           F+  +  A  Q R+G +  +       T   A E +    P  A F     A +A+LT F
Sbjct: 495 FQELYQVAQEQVRQGEKFLQP-----LTGWEAAELD----PPGARFL----ALRAQLTEF 541

Query: 945 YMA-AER--QRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLH 999
             A A+R  +  D E L  L R  + +TW   + Q ++A+L  ++   V    Q +LH
Sbjct: 542 SRALAQRCQRLADAERLFQLFR--EALTWAE-EGQRVLAELEQERPGVVL--QQLQLH 594


>gi|193211596 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  187 bits (474), Expect = 7e-47
 Identities = 167/538 (31%), Positives = 244/538 (45%), Gaps = 52/538 (9%)

Query: 485 TPEKASLQHNGPW-----KVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEK 538
           T E +S+   GP       +LC + S            G       GP+ A PS L+   
Sbjct: 86  TVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGA 145

Query: 539 AALPEASAGSP--ERGPTLEEEPPG---PEPRIGALGV----KVFRSRIACLPGGRDRAG 589
                   G P  E    LE  P G   P+P    L      ++  S +A LPG RD  G
Sbjct: 146 LDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQG 205

Query: 590 RPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVS 649
           R +LL+     AW    C+  E+ +LL YL +IPRPE +A GL VL+DAR   P   L S
Sbjct: 206 RAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFS 265

Query: 650 ALQATQAQVPASIRAILFLG-----EKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLP 704
            L   Q   P ++  +L +G     E  + LQL+ LP          ++L  H+  + LP
Sbjct: 266 GLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS---------QSLLTHIPTAGLP 316

Query: 705 AVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSK 764
             L G  PYCH  W+ F ++L+  L +   A +LLQ +IE  +    P    E  + L +
Sbjct: 317 TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQ 376

Query: 765 SKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLH 824
           ++ LM+ VL  P L  LQ +GG  L  L+ +   +  SPD R+ +  A  LY  VD  LH
Sbjct: 377 TEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLH 436

Query: 825 VLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAE 884
            L   SN  +  LEL   L   E+ +HQ+  W++Q G   L+     + SL+ + +A   
Sbjct: 437 QLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEE--AGEPSLDMLLQAQGS 494

Query: 885 FENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF 944
           F+  +  A  Q R+G +  +       T   A E +    P  A F     A +A+LT F
Sbjct: 495 FQELYQVAQEQVRQGEKFLQP-----LTGWEAAELD----PPGARFL----ALRAQLTEF 541

Query: 945 YMA-AER--QRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLH 999
             A A+R  +  D E L  L R  + +TW   + Q ++A+L  ++   V    Q +LH
Sbjct: 542 SRALAQRCQRLADAERLFQLFR--EALTWAE-EGQRVLAELEQERPGVVL--QQLQLH 594


>gi|193211594 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  187 bits (474), Expect = 7e-47
 Identities = 167/538 (31%), Positives = 244/538 (45%), Gaps = 52/538 (9%)

Query: 485 TPEKASLQHNGPW-----KVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEK 538
           T E +S+   GP       +LC + S            G       GP+ A PS L+   
Sbjct: 86  TVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGA 145

Query: 539 AALPEASAGSP--ERGPTLEEEPPG---PEPRIGALGV----KVFRSRIACLPGGRDRAG 589
                   G P  E    LE  P G   P+P    L      ++  S +A LPG RD  G
Sbjct: 146 LDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQG 205

Query: 590 RPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVS 649
           R +LL+     AW    C+  E+ +LL YL +IPRPE +A GL VL+DAR   P   L S
Sbjct: 206 RAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFS 265

Query: 650 ALQATQAQVPASIRAILFLG-----EKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLP 704
            L   Q   P ++  +L +G     E  + LQL+ LP          ++L  H+  + LP
Sbjct: 266 GLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS---------QSLLTHIPTAGLP 316

Query: 705 AVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSK 764
             L G  PYCH  W+ F ++L+  L +   A +LLQ +IE  +    P    E  + L +
Sbjct: 317 TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQ 376

Query: 765 SKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLH 824
           ++ LM+ VL  P L  LQ +GG  L  L+ +   +  SPD R+ +  A  LY  VD  LH
Sbjct: 377 TEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLH 436

Query: 825 VLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAE 884
            L   SN  +  LEL   L   E+ +HQ+  W++Q G   L+     + SL+ + +A   
Sbjct: 437 QLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEE--AGEPSLDMLLQAQGS 494

Query: 885 FENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF 944
           F+  +  A  Q R+G +  +       T   A E +    P  A F     A +A+LT F
Sbjct: 495 FQELYQVAQEQVRQGEKFLQP-----LTGWEAAELD----PPGARFL----ALRAQLTEF 541

Query: 945 YMA-AER--QRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLH 999
             A A+R  +  D E L  L R  + +TW   + Q ++A+L  ++   V    Q +LH
Sbjct: 542 SRALAQRCQRLADAERLFQLFR--EALTWAE-EGQRVLAELEQERPGVVL--QQLQLH 594


>gi|55742734 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 1 [Homo sapiens]
          Length = 1191

 Score =  187 bits (474), Expect = 7e-47
 Identities = 167/538 (31%), Positives = 244/538 (45%), Gaps = 52/538 (9%)

Query: 485 TPEKASLQHNGPW-----KVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEK 538
           T E +S+   GP       +LC + S            G       GP+ A PS L+   
Sbjct: 86  TVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGA 145

Query: 539 AALPEASAGSP--ERGPTLEEEPPG---PEPRIGALGV----KVFRSRIACLPGGRDRAG 589
                   G P  E    LE  P G   P+P    L      ++  S +A LPG RD  G
Sbjct: 146 LDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQG 205

Query: 590 RPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVS 649
           R +LL+     AW    C+  E+ +LL YL +IPRPE +A GL VL+DAR   P   L S
Sbjct: 206 RAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFS 265

Query: 650 ALQATQAQVPASIRAILFLG-----EKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLP 704
            L   Q   P ++  +L +G     E  + LQL+ LP          ++L  H+  + LP
Sbjct: 266 GLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPS---------QSLLTHIPTAGLP 316

Query: 705 AVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSK 764
             L G  PYCH  W+ F ++L+  L +   A +LLQ +IE  +    P    E  + L +
Sbjct: 317 TSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQ 376

Query: 765 SKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLH 824
           ++ LM+ VL  P L  LQ +GG  L  L+ +   +  SPD R+ +  A  LY  VD  LH
Sbjct: 377 TEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLH 436

Query: 825 VLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSLETVEKAHAE 884
            L   SN  +  LEL   L   E+ +HQ+  W++Q G   L+     + SL+ + +A   
Sbjct: 437 QLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEE--AGEPSLDMLLQAQGS 494

Query: 885 FENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQAELTHF 944
           F+  +  A  Q R+G +  +       T   A E +    P  A F     A +A+LT F
Sbjct: 495 FQELYQVAQEQVRQGEKFLQP-----LTGWEAAELD----PPGARFL----ALRAQLTEF 541

Query: 945 YMA-AER--QRTDLETLLHLHRFCKRMTWFHMDCQDLMAQLRLDKTSRVSPGDQRRLH 999
             A A+R  +  D E L  L R  + +TW   + Q ++A+L  ++   V    Q +LH
Sbjct: 542 SRALAQRCQRLADAERLFQLFR--EALTWAE-EGQRVLAELEQERPGVVL--QQLQLH 594


>gi|193211603 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4 isoform 2 [Homo sapiens]
          Length = 1110

 Score =  182 bits (463), Expect = 1e-45
 Identities = 157/507 (30%), Positives = 234/507 (46%), Gaps = 55/507 (10%)

Query: 517 AGTTQTKTSGPATAPSPLTEE----------KAALPEAS--AGSPERGP----TLEEEPP 560
           A     K  GP   P+  T++          K  LP A+  +G  +RG     ++  E P
Sbjct: 38  ASQMHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGP 97

Query: 561 GPEPRIGALGVKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLC 620
           GP      L      S ++   G RD  GR +LL+     AW    C+  E+ +LL YL 
Sbjct: 98  GPSGVESLLCP--MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLR 155

Query: 621 TIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLG-----EKEAAL 675
           +IPRPE +A GL VL+DAR   P   L S L   Q   P ++  +L +G     E  + L
Sbjct: 156 SIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGL 215

Query: 676 QLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQA 735
           QL+ LP          ++L  H+  + LP  L G  PYCH  W+ F ++L+  L +   A
Sbjct: 216 QLEQLPS---------QSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAA 266

Query: 736 SSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHD 795
            +LLQ +IE  +    P    E  + L +++ LM+ VL  P L  LQ +GG  L  L+ +
Sbjct: 267 CALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQE 326

Query: 796 ASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSD 855
              +  SPD R+ +  A  LY  VD  LH L   SN  +  LEL   L   E+ +HQ+  
Sbjct: 327 VPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEV 386

Query: 856 WMEQEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARG 915
           W++Q G   L+     + SL+ + +A   F+  +  A  Q R+G +  +       T   
Sbjct: 387 WLQQVGWPALEE--AGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQP-----LTGWE 439

Query: 916 AGEAERAEFPELAAFASTQRAFQAELTHFYMA-AER--QRTDLETLLHLHRFCKRMTWFH 972
           A E +    P  A F     A +A+LT F  A A+R  +  D E L  L R  + +TW  
Sbjct: 440 AAELD----PPGARFL----ALRAQLTEFSRALAQRCQRLADAERLFQLFR--EALTWAE 489

Query: 973 MDCQDLMAQLRLDKTSRVSPGDQRRLH 999
            + Q ++A+L  ++   V    Q +LH
Sbjct: 490 -EGQRVLAELEQERPGVVL--QQLQLH 513


>gi|148529025 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 4B [Homo sapiens]
          Length = 1271

 Score =  179 bits (454), Expect = 1e-44
 Identities = 114/306 (37%), Positives = 163/306 (53%), Gaps = 12/306 (3%)

Query: 542 PEASAGSPERGPTLEEE--PPGP-------EPRIGALGVKVFRSRIACLPGGRDRAGRPL 592
           P   +  P R P  E+E  PPG          ++  +  ++ +S +  LPG RDR GR +
Sbjct: 157 PSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAV 216

Query: 593 LLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQ 652
           + V T    W     + +E+T+LL Y  +IPR E +  GL VL+DARR P  P +  AL 
Sbjct: 217 VQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALS 276

Query: 653 ATQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLKALSHHVDPSQLPAVLEGPFP 712
             Q      I +IL L +KE+A +      +Q EV++SLKA+   VD  QL A L+G FP
Sbjct: 277 GLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFP 336

Query: 713 YCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAV 772
           Y H +W+ F Q+L+ F A+  +A   LQ S         P   QE    + + + +M+ V
Sbjct: 337 YSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLV 396

Query: 773 LRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNS 832
           L DP L+ L+ EGG  LARL+ +    +   D R  L AAT+LY  VDE++H LV  SN+
Sbjct: 397 LEDPLLVSLRLEGGTVLARLRREELGTE---DSRDTLEAATSLYDRVDEEVHRLVLTSNN 453

Query: 833 LLGKLE 838
            L +LE
Sbjct: 454 RLQQLE 459


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 137/595 (23%), Positives = 234/595 (39%), Gaps = 78/595 (13%)

Query: 575  RSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAV 634
            + R A L GGR + G P++         E P     E   +++YL +IP  +D   G  +
Sbjct: 104  KKRFAYLSGGRGQDGSPVITFPDYPAFSEIP---DKEFQNVMTYLTSIPSLQDAGIGFIL 160

Query: 635  LIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPD------------ 682
            +ID RR        S L+   A  PA+++ +L L  +      +TL D            
Sbjct: 161  VIDRRRDKWTSVKASVLRIA-ASFPANLQLVLVL--RPTGFFQRTLSDIAFKFNRDDFKM 217

Query: 683  -VQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQA 741
             V V +L+S+  L  ++D SQL   L G   YCH+ W+     ++ F   + Q + +LQ+
Sbjct: 218  KVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQS 277

Query: 742  SIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGA---TLARLQHDASR 798
               E  + + P  +Q  +  L    E  +    D  L    +EG +   +L  LQ + S 
Sbjct: 278  FGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRL--ALKEGHSVLESLRELQAEGSE 335

Query: 799  LDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWME 858
               + D   + A    L + ++E              KLE  ++L   E    +V   ++
Sbjct: 336  PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 395

Query: 859  QEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGE 918
               ++ + + T    SL  VE    +  +F  ++     R   LS    QL      A +
Sbjct: 396  AASQK-IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVD 454

Query: 919  AERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCK-RMTWFHMDCQD 977
            + R +  EL         F AE+        R+R  L   L LHR  +  M W    C +
Sbjct: 455  SIRPKCQELRHLCD---QFSAEIA-------RRRGLLSKSLELHRRLETSMKW----CDE 500

Query: 978  ---LMAQLRLDKTSRVSPGDQ--RRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQE 1032
               L+A   +DK       +   + + ++L+   +E   ++L A+  +  S+    L Q+
Sbjct: 501  GIYLLASQPVDKCQSQDGAEAALQEIEKFLE-TGAENKIQELNAIYKEYESI----LNQD 555

Query: 1033 LWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGVSVEVTSKGRWDQ 1092
            L E  R   ++   + E      +  +  AA   RP         Q V+           
Sbjct: 556  LMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPV--------QPVA----------- 596

Query: 1093 PPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGS----PPQEA-GQAAEAEDGKGS 1142
            P  ++L     P     PG  RG +N + + G+    P + A  + +E+  G+GS
Sbjct: 597  PRPEALAKSPCPS----PGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGS 647


>gi|163644323 MCF.2 cell line derived transforming sequence-like
            isoform b [Homo sapiens]
          Length = 1129

 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 137/595 (23%), Positives = 234/595 (39%), Gaps = 78/595 (13%)

Query: 575  RSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGLAV 634
            + R A L GGR + G P++         E P     E   +++YL +IP  +D   G  +
Sbjct: 51   KKRFAYLSGGRGQDGSPVITFPDYPAFSEIP---DKEFQNVMTYLTSIPSLQDAGIGFIL 107

Query: 635  LIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPD------------ 682
            +ID RR        S L+   A  PA+++ +L L  +      +TL D            
Sbjct: 108  VIDRRRDKWTSVKASVLRIA-ASFPANLQLVLVL--RPTGFFQRTLSDIAFKFNRDDFKM 164

Query: 683  -VQVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQA 741
             V V +L+S+  L  ++D SQL   L G   YCH+ W+     ++ F   + Q + +LQ+
Sbjct: 165  KVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQS 224

Query: 742  SIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGA---TLARLQHDASR 798
               E  + + P  +Q  +  L    E  +    D  L    +EG +   +L  LQ + S 
Sbjct: 225  FGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRL--ALKEGHSVLESLRELQAEGSE 282

Query: 799  LDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWME 858
               + D   + A    L + ++E              KLE  ++L   E    +V   ++
Sbjct: 283  PSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILD 342

Query: 859  QEGRRCLQSLTPKDGSLETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGE 918
               ++ + + T    SL  VE    +  +F  ++     R   LS    QL      A +
Sbjct: 343  AASQK-IATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVD 401

Query: 919  AERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCK-RMTWFHMDCQD 977
            + R +  EL         F AE+        R+R  L   L LHR  +  M W    C +
Sbjct: 402  SIRPKCQELRHLCD---QFSAEIA-------RRRGLLSKSLELHRRLETSMKW----CDE 447

Query: 978  ---LMAQLRLDKTSRVSPGDQ--RRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQE 1032
               L+A   +DK       +   + + ++L+   +E   ++L A+  +  S+    L Q+
Sbjct: 448  GIYLLASQPVDKCQSQDGAEAALQEIEKFLE-TGAENKIQELNAIYKEYESI----LNQD 502

Query: 1033 LWEEARIRHEEIRMLLEKALTHSSCPEAPAAHSARPERRGVAAKGQGVSVEVTSKGRWDQ 1092
            L E  R   ++   + E      +  +  AA   RP         Q V+           
Sbjct: 503  LMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPV--------QPVA----------- 543

Query: 1093 PPLDSLGMDHLPKSYWPPGPPRGEQNRTFQAGS----PPQEA-GQAAEAEDGKGS 1142
            P  ++L     P     PG  RG +N + + G+    P + A  + +E+  G+GS
Sbjct: 544  PRPEALAKSPCPS----PGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGS 594


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
           sapiens]
          Length = 3097

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 57/229 (24%), Positives = 99/229 (43%), Gaps = 9/229 (3%)

Query: 573 VFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGL 632
           + + ++A L GGRD+ G P+L   T             ++ +L+SYL  IP  E   +G 
Sbjct: 68  ILKEKVAYLSGGRDKRGGPIL---TFPARSNHDRIRQEDLRRLISYLACIPSEEVCKRGF 124

Query: 633 AVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQT---LPDVQVEV-L 688
            V++D R       +   L+  Q   P  I   L +       + +T       + E  +
Sbjct: 125 TVIVDMRGSK-WDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNM 183

Query: 689 TSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFEK 748
            SL+ L+  VDPSQL    +G   Y H EW+      + ++++     S L+   +   K
Sbjct: 184 VSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAK 243

Query: 749 ADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDAS 797
            + P  ++ A   + +  +L + V++ P +  L  EG   L R+Q   S
Sbjct: 244 KELPQDLEGARNMIEEHSQLKKKVIKAP-IEDLDLEGQKLLQRIQSSES 291



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 60/293 (20%), Positives = 111/293 (37%), Gaps = 34/293 (11%)

Query: 717 EWVHFFQKLDP--FLADL----HQASSLLQASIEEFEKA----DPPGGMQEATRCLSKSK 766
           EW  F   LD    L D+    HQ +    ++++ + KA    D P  +Q+    +   +
Sbjct: 429 EWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQ 488

Query: 767 ELMEAVLRDPGLLGLQREGGATLARLQHDAS--RLDFSPDVRSHLAAATALYSLVDEQLH 824
            + E +        + ++G + L +LQ   +    D      ++  A   +  ++ E LH
Sbjct: 489 GIYEHITL--AYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDVIHEVLH 546

Query: 825 VLVTASNSLLGK---LELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSL---ETV 878
                 N    +   L  R++L   +  + QV DW+E  G   L   T    SL     +
Sbjct: 547 HQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARAL 606

Query: 879 EKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFASTQRAFQ 938
           +K H +FE           + LE ++Q AQ        GE +  E  + A         +
Sbjct: 607 QKRHEDFEEVAQNTYTNADKLLEAAEQLAQ-------TGECDPEEIYQAA------HQLE 653

Query: 939 AELTHFYMAAERQRTDLETLLHLHRFCKRM-TWFHMDCQDLMAQLRLDKTSRV 990
             +  F    E+++  L+  +  H   K + TW     ++L+  +  +    V
Sbjct: 654 DRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAV 706


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 78/351 (22%), Positives = 144/351 (41%), Gaps = 19/351 (5%)

Query: 573 VFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGL 632
           + + ++A + GGRD+ G P+L   T             ++ KL++YL ++P  +   +G 
Sbjct: 38  ILKEKVAFVSGGRDKRGGPIL---TFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94

Query: 633 AVLIDARRQPPQPGLVSALQAT-QAQVPASIRAILFLGE----KEAALQLQTLPDVQVEV 687
            V+ID R    +  L+  L  T Q   PA I   L +      ++      +   +    
Sbjct: 95  TVIIDMRGS--KWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETS 152

Query: 688 LTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFE 747
           + S++ L+  VDPSQL    +G   Y H EW+     L+ F        S L+   E   
Sbjct: 153 MVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLA 212

Query: 748 KADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQ-----HDASRLDFS 802
           + + P  ++ + R + +  +L + VL+ P +  L REG   L  ++        + +  S
Sbjct: 213 RKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPGS 271

Query: 803 PDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGR 862
            D +S +   T+L   +      L    +    KL+   +L   E    ++ DW+     
Sbjct: 272 ADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKE 331

Query: 863 RCLQSLTPKDGSLE---TVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLG 910
             LQS T    S +    ++  H  F    + A     R + ++ + ++ G
Sbjct: 332 LFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAG 382



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 78/347 (22%), Positives = 129/347 (37%), Gaps = 61/347 (17%)

Query: 717  EWVHFFQKLDP------FLADLHQASSLLQASIEEFEKADPPGG----MQEATRCLSKSK 766
            EW  F   LD         A  HQ +    + ++ + K    GG    MQ+    +   +
Sbjct: 399  EWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQ 458

Query: 767  ELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYS--------L 818
             L E V +      + ++G A L  LQ   S         S    ATA YS        +
Sbjct: 459  TLYEQVTQ--AYTEVSQDGKALLDVLQRPLS------PGNSESLTATANYSKAVHQVLDV 510

Query: 819  VDEQLHV---LVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSL 875
            V E LH    L +       +L  R++L   +  + QV DW+E  G   L   T    SL
Sbjct: 511  VHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL 570

Query: 876  E---TVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFAS 932
                 ++K H +FE           + LE ++Q AQ        GE +  E  + A    
Sbjct: 571  HRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQ-------TGECDPEEIYKAA---- 619

Query: 933  TQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRM-TWFHMDCQDLMAQLRLDKTSRVS 991
              R  +  +  F    E+++  L+  +  H   K + TW     ++++  +  D    V 
Sbjct: 620  --RHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV- 676

Query: 992  PGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQELWEEAR 1038
                       Q L  +F  ++ A +    A+L+    G++L ++ R
Sbjct: 677  -----------QELIKQFQQQQTATLD---ATLNVIKEGEDLIQQLR 709



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 40/170 (23%), Positives = 64/170 (37%), Gaps = 17/170 (10%)

Query: 810  AAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLT 869
            A    L   + E+ H L   +     +LE  ++L  L+A + QV  W+ + G   L +  
Sbjct: 859  AQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWI-RNGESMLNASL 917

Query: 870  PKDGSLETVEKAHAEFENFFL---------------QAAAQYRRGLELSKQAAQLGATA- 913
                SL   E+   E E F L               Q+A Q ++  E+  QA    A A 
Sbjct: 918  VNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAI 977

Query: 914  RGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHR 963
            R   E     + +L      +         FY  +E+  + LE+L   +R
Sbjct: 978  RECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYR 1027


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 78/351 (22%), Positives = 144/351 (41%), Gaps = 19/351 (5%)

Query: 573 VFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAKGL 632
           + + ++A + GGRD+ G P+L   T             ++ KL++YL ++P  +   +G 
Sbjct: 38  ILKEKVAFVSGGRDKRGGPIL---TFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGF 94

Query: 633 AVLIDARRQPPQPGLVSALQAT-QAQVPASIRAILFLGE----KEAALQLQTLPDVQVEV 687
            V+ID R    +  L+  L  T Q   PA I   L +      ++      +   +    
Sbjct: 95  TVIIDMRGS--KWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETS 152

Query: 688 LTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEEFE 747
           + S++ L+  VDPSQL    +G   Y H EW+     L+ F        S L+   E   
Sbjct: 153 MVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLA 212

Query: 748 KADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQ-----HDASRLDFS 802
           + + P  ++ + R + +  +L + VL+ P +  L REG   L  ++        + +  S
Sbjct: 213 RKEFPVDVEGSRRLIDEHTQLKKKVLKAP-VEELDREGQRLLQCIRCSDGFSGRNCIPGS 271

Query: 803 PDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGR 862
            D +S +   T+L   +      L    +    KL+   +L   E    ++ DW+     
Sbjct: 272 ADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKE 331

Query: 863 RCLQSLTPKDGSLE---TVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLG 910
             LQS T    S +    ++  H  F    + A     R + ++ + ++ G
Sbjct: 332 LFLQSHTEIGVSYQYALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAG 382



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 78/347 (22%), Positives = 129/347 (37%), Gaps = 61/347 (17%)

Query: 717  EWVHFFQKLDP------FLADLHQASSLLQASIEEFEKADPPGG----MQEATRCLSKSK 766
            EW  F   LD         A  HQ +    + ++ + K    GG    MQ+    +   +
Sbjct: 399  EWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQ 458

Query: 767  ELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDVRSHLAAATALYS--------L 818
             L E V +      + ++G A L  LQ   S         S    ATA YS        +
Sbjct: 459  TLYEQVTQ--AYTEVSQDGKALLDVLQRPLS------PGNSESLTATANYSKAVHQVLDV 510

Query: 819  VDEQLHV---LVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLTPKDGSL 875
            V E LH    L +       +L  R++L   +  + QV DW+E  G   L   T    SL
Sbjct: 511  VHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL 570

Query: 876  E---TVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGATARGAGEAERAEFPELAAFAS 932
                 ++K H +FE           + LE ++Q AQ        GE +  E  + A    
Sbjct: 571  HRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQ-------TGECDPEEIYKAA---- 619

Query: 933  TQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRM-TWFHMDCQDLMAQLRLDKTSRVS 991
              R  +  +  F    E+++  L+  +  H   K + TW     ++++  +  D    V 
Sbjct: 620  --RHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDVCADSVDAV- 676

Query: 992  PGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLGQELWEEAR 1038
                       Q L  +F  ++ A +    A+L+    G++L ++ R
Sbjct: 677  -----------QELIKQFQQQQTATLD---ATLNVIKEGEDLIQQLR 709



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 40/170 (23%), Positives = 64/170 (37%), Gaps = 17/170 (10%)

Query: 810  AAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCLQSLT 869
            A    L   + E+ H L   +     +LE  ++L  L+A + QV  W+ + G   L +  
Sbjct: 859  AQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWI-RNGESMLNASL 917

Query: 870  PKDGSLETVEKAHAEFENFFL---------------QAAAQYRRGLELSKQAAQLGATA- 913
                SL   E+   E E F L               Q+A Q ++  E+  QA    A A 
Sbjct: 918  VNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEVLLQAGHYDADAI 977

Query: 914  RGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHR 963
            R   E     + +L      +         FY  +E+  + LE+L   +R
Sbjct: 978  RECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYR 1027


>gi|188528641 SEC14 and spectrin domains 1 [Homo sapiens]
          Length = 696

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 107/479 (22%), Positives = 189/479 (39%), Gaps = 68/479 (14%)

Query: 573  VFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWC----TVSEVTKLLSYLCTIPRPEDK 628
            + + ++A L GG+DR    +L +         P C     + E++  L YL +IP  + K
Sbjct: 9    ILKKKLAFLSGGKDRRSGLILTI---------PLCLEQTNMDELSVTLDYLLSIPSEKCK 59

Query: 629  AKGLAVLIDARRQPPQPGLV-SALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVE- 686
            A+G  V++D R+   Q  +V + +   Q  VPA +  +  +   E   +  T      E 
Sbjct: 60   ARGFTVIVDGRKS--QWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEK 117

Query: 687  -------VLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLL 739
                   +L S   L+ +++P QL     G   Y H +W++     + F  +    S+ L
Sbjct: 118  DRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKE----STSL 173

Query: 740  QASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQH----- 794
               +         G  QE  R    S +L      DP    + + G   L+ LQ      
Sbjct: 174  LDELALINNGSDKGNQQEKER----SVDLNFLPSVDPET--VLQTGHELLSELQQRRFNG 227

Query: 795  DASRLDFSPDVRSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVS 854
                + +SP +   L A   +  L+D  L    T    +  +   R +L  ++  + QV 
Sbjct: 228  SDGGVSWSP-MDDELLAQPQVMKLLD-SLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVV 285

Query: 855  DWMEQEGRRCLQSLTPKDGSL---ETVEKAHAEFENFFLQAAAQYRRGLELSKQAAQLGA 911
            +W+E  G   L++      S+   + +++ H E E+   +  A Y   +EL++Q A L  
Sbjct: 286  NWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVY---VELNQQIAAL-- 340

Query: 912  TARGAGEAERAEFPELAAFASTQRAFQAELTHFYMAAERQRTDLETLLHLHRFCKRMTWF 971
                AG+ E     +L    S Q+             E ++  L+  L  H   + ++  
Sbjct: 341  --LNAGDEE-----DLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLS-- 391

Query: 972  HMDCQDLMAQLRLDKTSRVSPGDQRRLHRYLQRLASEFPAEKLAAVGLQVASLSRAGLG 1030
                  L+  L +D    V+P D   + + L+ L      EKL +V + +  L   G G
Sbjct: 392  -QQLDGLLGMLCVD----VAPADGASIQQTLKLL-----EEKLKSVDVGLQGLREKGQG 440


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 53/245 (21%), Positives = 103/245 (42%), Gaps = 20/245 (8%)

Query: 612 VTKLLSYLCTIPRPEDKAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEK 671
           + K+L+YL +I R         +++D RR      L  +LQ   A  P ++  +L L  +
Sbjct: 35  IAKVLTYLTSIARQNGSDSRFTIILD-RRLDTWSSLKISLQKISASFPGNLHLVLVL--R 91

Query: 672 EAALQLQTLPDV-------------QVEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEW 718
             +   +T  D+              V +L+S+  L  ++D  QL   L G   YCH+EW
Sbjct: 92  PTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEW 151

Query: 719 VHFFQKLDPFLADLHQASSLLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGL 778
           + F   ++ F   + + + +LQ+   E  + + P  +      L+   E    +  D  +
Sbjct: 152 IIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKND--I 209

Query: 779 LGLQREGGATLARLQHDASRLDFSPDVRSH--LAAATALYSLVDEQLHVLVTASNSLLGK 836
             + +EG   L  L+   +    S  +  H  ++      + +  Q+H + TA +    K
Sbjct: 210 TAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEK 269

Query: 837 LELRV 841
            +L++
Sbjct: 270 HQLKM 274


>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
           sapiens]
          Length = 1114

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 53/241 (21%), Positives = 99/241 (41%), Gaps = 21/241 (8%)

Query: 571 VKVFRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPEDKAK 630
           ++    + A L GGR   G P++      G    P     +   +++YL +IP  E  + 
Sbjct: 42  IEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIP---DEDFLNVMTYLTSIPSVEAASI 98

Query: 631 GLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVE---- 686
           G  V+ID RR+     + ++L       P +++ I  L  + +    +T  D+ ++    
Sbjct: 99  GFIVVID-RRRDKWSSVKASLTRIAVAFPGNLQLIFIL--RPSRFIQRTFTDIGIKYYRN 155

Query: 687 ---------VLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASS 737
                    ++ S+  L  ++D SQL   L G   Y H +WV+    ++ F   L   + 
Sbjct: 156 EFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQ 215

Query: 738 LLQASIEEFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDAS 797
           +LQ        A+ P  M      L       + +  +  LLG  ++G   L+ +Q  A+
Sbjct: 216 MLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLG--KQGTTLLSCIQEPAT 273

Query: 798 R 798
           +
Sbjct: 274 K 274


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 100/426 (23%), Positives = 160/426 (37%), Gaps = 74/426 (17%)

Query: 199  QAWGPLPLEALDL--SSPQELHQASSPDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARC 256
            Q  GP  L + +   ++ +E  QA+ P  +  PA SL              ++++ QA  
Sbjct: 1217 QPTGPRGLGSFEYQDTTDREYGQAAQPAAEGTPA-SLGAAVYEEILQTSQSIVRMRQASS 1275

Query: 257  GEVAFRMDEVVSQDFEGDYVALLGFSQESRGE-----SPSREAG-------TSSGCTSGA 304
             ++AF  D+   + F     A +   +++ G      SP++ A        TSS  + G 
Sbjct: 1276 RDLAFAEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLAAPVSFSTPTSSDSSGGR 1335

Query: 305  L-------EEIAGTKETPLFQKILPLSEANEGPSLG---NRACTKPESSEERPYNLGFRR 354
            +       +  A   + PL     P S ++    +G   ++    P ++   P   G  R
Sbjct: 1336 VIPDVRVTQHFAKETQDPLKLHSSPASPSSASKEIGMPFSQGPGTPATTAVAPCPAGLPR 1395

Query: 355  KVNLKAPTHNSERPPQGS--------------YMNVLEDALDCASGLRAG--VSQEPAAS 398
                 A    SER P  S              Y +  ED     SGL A    ++E   S
Sbjct: 1396 GYMTPASPAGSERSPSPSSTAHSYGHSPTTANYGSQTEDLPQAPSGLAAAGRAAREKPLS 1455

Query: 399  KMQGPLGNPENMVQLRPGPRQA------SSPRLSPASPAAAASETKIEV---KTKERNGR 449
               G  G P+        P +A      SSP LSP+SP+ + + +  ++    T E + +
Sbjct: 1456 ASDGEGGTPQ--------PSRAYSYFASSSPPLSPSSPSESPTFSPGKMGPRATAEFSTQ 1507

Query: 450  LPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPN 509
             P P P  S    SP  PTP    +      Q + TP + S     P  V        P 
Sbjct: 1508 TPSPAPA-SDMPRSPGAPTPSPMVA------QGTQTPHRPST----PRLVWQESSQEAPF 1556

Query: 510  RAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEE---EPPGPE--P 564
               +L    ++QT+    + + SPL       P     S    P++ +   EPPGP   P
Sbjct: 1557 MVITLASDASSQTRMVHASASTSPLCSPTETQPTTHGYSQTTPPSVSQLPPEPPGPPGFP 1616

Query: 565  RIGALG 570
            R+ + G
Sbjct: 1617 RVPSAG 1622



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 57/235 (24%), Positives = 85/235 (36%), Gaps = 34/235 (14%)

Query: 380  ALDCASGLRAGVSQEPAASKMQGPLGNPENMV-QLRPGPRQASSPRLSPASPAAAASETK 438
            A D   G R   S   A      P   P+    Q  PGP+Q+ SP        AA+ + +
Sbjct: 3718 ASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQIPSGAASRQPQ 3777

Query: 439  IEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWK 498
             + + +    + P+     +R     +P T G          QP+  P+       GP  
Sbjct: 3778 TQQQQQGLGLQPPQQALTQARLQQQSQPTTRG----SAPAASQPAGKPQPGPSTATGPQP 3833

Query: 499  VLCSLYSPKPNRAKSLGKAGTTQTKTSG------PATAPSPLTEEKAALPEASAGSPERG 552
                  +  P   ++ G  GT +    G      PA  P P   +  A P  + G+P   
Sbjct: 3834 ------AGPPRAEQTNGSKGTAKAPQQGRAPQAQPAPGPGPAGVKAGARPGGTPGAPAGQ 3887

Query: 553  PTLEEEPPGPEPRIGALGVKVFRSRIACLPGG-RDRAGRPLLLVSTTEGAWEAPW 606
            P             GA G  VF S+I  LPGG  ++AG+    VS     + + W
Sbjct: 3888 P-------------GADGESVF-SKI--LPGGAAEQAGKLTEAVSAFGKKFSSFW 3926



 Score = 35.8 bits (81), Expect = 0.25
 Identities = 41/158 (25%), Positives = 60/158 (37%), Gaps = 26/158 (16%)

Query: 448 GRLPKPMPCPSRNTSSPEPPTPG-------LKFSFLRGQRQPS-VTPEKASLQHNGPWKV 499
           G L +P P P   +  P    P        LK    +G  QPS   P KAS         
Sbjct: 523 GSLGEPTPLPPPTSQQPPVGAPHRASGTSPLKQKGPQGLGQPSGPLPAKAS--------P 574

Query: 500 LCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEP 559
           L +  SP P++A    K      + S P+  PS + E+K  +P  +   P+  P     P
Sbjct: 575 LSTKASPLPSKASPQAKP----LRASEPSKTPSSVQEKKTRVPTKAEPMPKPPPETTPTP 630

Query: 560 PGPEPRIGALGVKVFRSRIACLP----GG--RDRAGRP 591
             P+ + G    +     +  +P    GG   D  G+P
Sbjct: 631 ATPKVKSGVRRAEPATPVVKAVPEAPKGGEAEDLVGKP 668



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 48/190 (25%), Positives = 74/190 (38%), Gaps = 26/190 (13%)

Query: 420  ASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTP----GLKFSF 475
            ASS RL+ A     + +      +  R   LP+PM    R+ S P+P +P      K  F
Sbjct: 2812 ASSERLNKAH---VSPQKHFTADSALRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERF 2868

Query: 476  LRGQRQPSVTPEKASLQHNG-PWKVLCSLYSPKPNRA---------KSLGKAGTTQTKTS 525
               Q Q  +  + ++L  N    KV  +L SP P  A           L  A   Q   +
Sbjct: 2869 SLYQHQGGLGSQVSALPPNSLVRKVKRTLPSPPPEEAHLPLAGQASPQLYAASLLQRGLT 2928

Query: 526  GPATAPS-------PLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIG--ALGVKVFRS 576
            GP T P+        L  +   +   S    ++   L+EE    + ++    LG+   + 
Sbjct: 2929 GPTTVPATKASLLRELDRDLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKE 2988

Query: 577  RIACLPGGRD 586
             +A   GGRD
Sbjct: 2989 SLAKDRGGRD 2998



 Score = 32.3 bits (72), Expect = 2.8
 Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 15/80 (18%)

Query: 395 PAASKMQGPLGNPENMVQL-----RPGPRQASSPR-LSPASPAAAASETKIEVKTKERNG 448
           PA S  + PLG P+          +PG RQA + R  S   PA AA+  ++        G
Sbjct: 249 PAHSPAKQPLGKPDQERSRGPGGPQPGSRQAETARATSVPGPAQAAAPPEV--------G 300

Query: 449 RLPKPMPCPSR-NTSSPEPP 467
           R+    P P++ +T+ P PP
Sbjct: 301 RVSPQPPQPTKPSTAEPRPP 320



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 19/68 (27%), Positives = 29/68 (42%)

Query: 503  LYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGP 562
            +Y  KP  AK+ G  G ++ +    A    PL     A  + +AG+P   P   ++PP  
Sbjct: 2280 VYLGKPAAAKAPGAGGPSRPEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPAD 2339

Query: 563  EPRIGALG 570
                G  G
Sbjct: 2340 AAPGGGSG 2347


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 44/176 (25%), Positives = 68/176 (38%), Gaps = 18/176 (10%)

Query: 388 RAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKE-R 446
           R   S  P   +   P   P+  V   P P+Q SSP     SP+ ++   K    ++  R
Sbjct: 612 RRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTR 671

Query: 447 NGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSP 506
             R P+P     R++ SP P  P    S    +R  S +P++                SP
Sbjct: 672 EARSPQPN---KRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQ--------------SP 714

Query: 507 KPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGP 562
            P+       + T + K    A +PSP +  + +   + +GSPE        PP P
Sbjct: 715 SPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSP 770



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 39/180 (21%), Positives = 58/180 (32%), Gaps = 19/180 (10%)

Query: 395 PAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPM 454
           P       P   P    +  P P+Q++  R S  S +   +  K+           P P 
Sbjct: 395 PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPA 454

Query: 455 PCPSRNTSSPEPPTPGLKFSF---------LRGQRQPSVTPEKASLQHNGPWKVLCSLYS 505
           P P +   S      G K +           R Q Q S +   +S               
Sbjct: 455 PKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDE--------R 506

Query: 506 PKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEA-SAGSPERGPTLEEEPPGPEP 564
           PK +  K+ G+ G  +  +   + +PSP   +K   P      SP   PT     P P P
Sbjct: 507 PKRSHVKN-GEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAP 565



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 39/155 (25%), Positives = 56/155 (36%), Gaps = 25/155 (16%)

Query: 416 GPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEP--------- 466
           G R+  SP     S +A+ S  K + +T  R  R   P P P+R   SP P         
Sbjct: 518 GRRRRHSP-----SRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRT 572

Query: 467 PTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSG 526
           PTP  +      +R PS  P + S         +   YSP P   +          + + 
Sbjct: 573 PTPPPR------RRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRAS 626

Query: 527 PATAPSPLTEEKAALPEASAGSP---ERGPTLEEE 558
           P  +P P      + P     SP    R P+L  +
Sbjct: 627 P--SPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSK 659



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 37/154 (24%), Positives = 54/154 (35%), Gaps = 18/154 (11%)

Query: 414 RPGPRQASSPRLSPASPAAAASETKIEVK-----------TKERNGRLPKPMPCPSRNTS 462
           RP PR+ + PR  P  P    S + +  +           +   + R   P   P + TS
Sbjct: 320 RPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTS 379

Query: 463 SPEPPTPGLKFSFLRGQRQ----PSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAG 518
           SP   T  L  S    +R+    P  TP   +     P +   S  + K   + S G+  
Sbjct: 380 SPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQ---SNRTRKSRVSVSPGRTS 436

Query: 519 TTQTKTSGPATAPSPLTEEKAALPEASAGSPERG 552
              TK  G     SP    K    E S    ++G
Sbjct: 437 GKVTKHKGTEKRESPSPAPKPRKVELSESEEDKG 470



 Score = 31.6 bits (70), Expect = 4.7
 Identities = 36/160 (22%), Positives = 54/160 (33%), Gaps = 31/160 (19%)

Query: 406 NPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPE 465
           +P       P PR+ SSP       + + S      +TK R+     P P P +   +PE
Sbjct: 171 SPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRH---RTKSRS-----PSPAPEKKEKTPE 222

Query: 466 PPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTS 525
            P P +K       ++PSV    ++            L  PKP            + K  
Sbjct: 223 LPEPSVKV------KEPSVQEATSTSD---------ILKVPKPE--------PIPEPKEP 259

Query: 526 GPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPEPR 565
            P        E++   P + + S  R  T    P    PR
Sbjct: 260 SPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPR 299


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 55/177 (31%), Positives = 67/177 (37%), Gaps = 31/177 (17%)

Query: 406  NPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPS----RNT 461
            N    V+ RP   QA  P L P  P A    T +          LP P+P P     +  
Sbjct: 1172 NGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDL--------AHLP-PLPPPEGEARKPA 1222

Query: 462  SSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQ 521
              P  P P L     + Q  P+ T +K  L   G         SP+  RA   G      
Sbjct: 1223 KPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPG---------SPEVKRAH--GTPPPVS 1271

Query: 522  TKTSGPATAPSPLTEEKAALPEASAG-----SPERGPTLE-EEPPGPEPRIGALGVK 572
             K   P TAP P+ +  A LP  SAG     SP R P     +PPG  P +GA   K
Sbjct: 1272 PKPPPPPTAPKPV-KAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAK 1327


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 51/177 (28%), Positives = 67/177 (37%), Gaps = 28/177 (15%)

Query: 395 PAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPM 454
           PA S     LG+  +    +P P       L+P  P    S    E++T      LP P 
Sbjct: 128 PALSMETQKLGSVLSPESPKPTP-------LTPLEPQKPGSVVSPELQTP-----LPSPE 175

Query: 455 PCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSL 514
           P    + SSPEPP         +    PS  P+K +     P  V  +L +PKP +    
Sbjct: 176 PSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPA--PVSPESVKATLSNPKPQKQSHF 233

Query: 515 GKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGP-------TLEEEPPGPEP 564
                   +T GP +A SP +   AA PE    SP   P       T   EP  P P
Sbjct: 234 -------PETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSP 283



 Score = 32.0 bits (71), Expect = 3.6
 Identities = 69/302 (22%), Positives = 99/302 (32%), Gaps = 63/302 (20%)

Query: 290 PSREAGTSSG--------CTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPE 341
           PS+ A  SS         C S  L  +     +P  QK  P+S  +   +L N    KP+
Sbjct: 176 PSKPASVSSPEPPKSVPVCESQKLAPVP----SPEPQKPAPVSPESVKATLSN---PKPQ 228

Query: 342 SSEERPYNLGFRRKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQ 401
                P  LG     + ++P   +   P G       ++   A       S EP   +  
Sbjct: 229 KQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSART----TSPEP---RKP 281

Query: 402 GPLGNPEN---MVQLRPGPRQASSPRLSPAS--PAAAASETKIEVKTKERNGRLPKPMPC 456
            P  +PE       + P PR+ + P +SP S  P    S    +      +G      P 
Sbjct: 282 SPSESPEPWKPFPAVSPEPRRPA-PAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPA 340

Query: 457 PSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPK--------- 507
           PS    SP P  P            PSV+P        GPWK   S+ S           
Sbjct: 341 PS---VSPGPWKP-----------IPSVSP--------GPWKPTPSVSSASWKSSSVSPS 378

Query: 508 ----PNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPE 563
               P  +    K+G  + + + P  +P          PE     P   P +      PE
Sbjct: 379 SWKSPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPE 438

Query: 564 PR 565
            R
Sbjct: 439 LR 440


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 86/382 (22%), Positives = 134/382 (35%), Gaps = 53/382 (13%)

Query: 202 GPLPLEALDLSSPQELHQASS---PDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGE 258
           GPL  + L +S+ + + +  +   P    L A +     G T G+  P + +  +A   E
Sbjct: 118 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 177

Query: 259 VAFRMDEVVSQD---FEGDYVALLGFSQESRGE-SPSREAGTSSGCTSGALEEIAGTKET 314
           V        ++     EG   ++   S+ S  E SP+     S+G   G L+  A     
Sbjct: 178 VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG---GGLQRPASRS-- 232

Query: 315 PLFQKILPLSE-ANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSERPPQGSY 373
            L     PLS  A  GPS           S+ +P  L              + RPPQ + 
Sbjct: 233 -LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL-------------QALRPPQVTP 278

Query: 374 MNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAA 433
               +DA      L +     P+ S    P   P   +Q  P P         PA+P + 
Sbjct: 279 PR--KDAAPALGPLSSSPLATPSPSAPPSPSAPPS--LQTLPSP---------PATPPSQ 325

Query: 434 ASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQH 493
           A+ +      +  +  LP P P     T  P+ P P L    L+    P  +P  + L  
Sbjct: 326 ATTSLGSPTLQATHSFLPSP-PLSPLATPPPQAP-PALALPPLQAPPSPPASPPLSPLAT 383

Query: 494 NGPWK-------VLCSLYSPKPNRAK----SLGKAGTTQTKTSGPATAPSPLTEEKAALP 542
             P         +L + +SP P+       S   +       + P+ AP  L      +P
Sbjct: 384 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443

Query: 543 EASAGSPERGPTLEEEPPGPEP 564
            +   SP   P+    P  P P
Sbjct: 444 PSPPASPPMSPSATPPPQAPPP 465



 Score = 33.9 bits (76), Expect = 0.95
 Identities = 46/181 (25%), Positives = 63/181 (34%), Gaps = 32/181 (17%)

Query: 386 GLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKE 445
           G    V ++P A +  G  G        R GP + S P      PA+   E     K   
Sbjct: 48  GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRP------PASGRGERAPPAKNTS 101

Query: 446 RNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYS 505
                P P+  P R + +  P   G K   LR   + +V   KA+              +
Sbjct: 102 -----PGPVSSPGRASGTTRPGPLGQKG--LRISAEETVARGKAT-------------EA 141

Query: 506 PKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEKAALPEASAGSPERGPTLEEEPPGPEP 564
           PK    +S   AG  +  TSGP    PSP    ++       G P   P+    PP   P
Sbjct: 142 PK----RSALSAGARRD-TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 196

Query: 565 R 565
           R
Sbjct: 197 R 197


>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
           [Homo sapiens]
          Length = 1285

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 69/258 (26%), Positives = 90/258 (34%), Gaps = 34/258 (13%)

Query: 369 PQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNP-ENMVQLRPGPRQASSPRLSP 427
           P+G Y +    AL   S   A  S  PA  ++    G+P E      PG     +  +SP
Sbjct: 650 PEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISP 709

Query: 428 ASPAAAAS-ETKIEVKTKERNGRLPKP----MPCPSRNTSSPEPPTPGLKFSFLRGQ--- 479
            SP    S +   E+ T+E   R P P       P  +  S EP       S+  G    
Sbjct: 710 GSPPYPQSRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEP------VSWREGPSGH 763

Query: 480 ----RQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLT 535
               R P   P  AS + +GP        +P    +   GK  T +  T  P +AP+   
Sbjct: 764 STLPRSPRDAPCSASSELSGP-------STPLHTSSPVQGKESTRRQDTRSPTSAPTQRL 816

Query: 536 EEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIAC------LPGGRDRAG 589
               ALP  S     + P L     GPEP   +     F             PGG     
Sbjct: 817 SPGEALPPVSQAGTGKAPEL-PSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGA 875

Query: 590 RPLLLVSTT-EGAWEAPW 606
            P   V TT  G   APW
Sbjct: 876 SPRSPVPTTLPGLRHAPW 893



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 354 RKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQL 413
           RK++ + PT       +G     L   L  A  L +  S EP + + +GP G+       
Sbjct: 718 RKLSYEIPTE------EGGDRYPLPGHLASAGPLASAESLEPVSWR-EGPSGHSTLPRSP 770

Query: 414 RPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPP 467
           R  P  ASS    P++P   +S  + +  T+ ++ R P   P    +     PP
Sbjct: 771 RDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPP 824


>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
            [Homo sapiens]
          Length = 1409

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 69/258 (26%), Positives = 90/258 (34%), Gaps = 34/258 (13%)

Query: 369  PQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNP-ENMVQLRPGPRQASSPRLSP 427
            P+G Y +    AL   S   A  S  PA  ++    G+P E      PG     +  +SP
Sbjct: 774  PEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISP 833

Query: 428  ASPAAAAS-ETKIEVKTKERNGRLPKP----MPCPSRNTSSPEPPTPGLKFSFLRGQ--- 479
             SP    S +   E+ T+E   R P P       P  +  S EP       S+  G    
Sbjct: 834  GSPPYPQSRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEP------VSWREGPSGH 887

Query: 480  ----RQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLT 535
                R P   P  AS + +GP        +P    +   GK  T +  T  P +AP+   
Sbjct: 888  STLPRSPRDAPCSASSELSGP-------STPLHTSSPVQGKESTRRQDTRSPTSAPTQRL 940

Query: 536  EEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIAC------LPGGRDRAG 589
                ALP  S     + P L     GPEP   +     F             PGG     
Sbjct: 941  SPGEALPPVSQAGTGKAPEL-PSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGA 999

Query: 590  RPLLLVSTT-EGAWEAPW 606
             P   V TT  G   APW
Sbjct: 1000 SPRSPVPTTLPGLRHAPW 1017



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 354 RKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQL 413
           RK++ + PT       +G     L   L  A  L +  S EP + + +GP G+       
Sbjct: 842 RKLSYEIPTE------EGGDRYPLPGHLASAGPLASAESLEPVSWR-EGPSGHSTLPRSP 894

Query: 414 RPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPP 467
           R  P  ASS    P++P   +S  + +  T+ ++ R P   P    +     PP
Sbjct: 895 RDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPP 948


>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
            [Homo sapiens]
          Length = 1419

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 69/258 (26%), Positives = 90/258 (34%), Gaps = 34/258 (13%)

Query: 369  PQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNP-ENMVQLRPGPRQASSPRLSP 427
            P+G Y +    AL   S   A  S  PA  ++    G+P E      PG     +  +SP
Sbjct: 784  PEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISP 843

Query: 428  ASPAAAAS-ETKIEVKTKERNGRLPKP----MPCPSRNTSSPEPPTPGLKFSFLRGQ--- 479
             SP    S +   E+ T+E   R P P       P  +  S EP       S+  G    
Sbjct: 844  GSPPYPQSRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEP------VSWREGPSGH 897

Query: 480  ----RQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLT 535
                R P   P  AS + +GP        +P    +   GK  T +  T  P +AP+   
Sbjct: 898  STLPRSPRDAPCSASSELSGP-------STPLHTSSPVQGKESTRRQDTRSPTSAPTQRL 950

Query: 536  EEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIAC------LPGGRDRAG 589
                ALP  S     + P L     GPEP   +     F             PGG     
Sbjct: 951  SPGEALPPVSQAGTGKAPEL-PSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGA 1009

Query: 590  RPLLLVSTT-EGAWEAPW 606
             P   V TT  G   APW
Sbjct: 1010 SPRSPVPTTLPGLRHAPW 1027



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 7/114 (6%)

Query: 354 RKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQL 413
           RK++ + PT       +G     L   L  A  L +  S EP + + +GP G+       
Sbjct: 852 RKLSYEIPTE------EGGDRYPLPGHLASAGPLASAESLEPVSWR-EGPSGHSTLPRSP 904

Query: 414 RPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPP 467
           R  P  ASS    P++P   +S  + +  T+ ++ R P   P    +     PP
Sbjct: 905 RDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPP 958


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 35/159 (22%), Positives = 70/159 (44%), Gaps = 4/159 (2%)

Query: 685 VEVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIE 744
           V +L+S+  L  ++D  QL   L G   YCH+EW+ F   ++ F   + + + +LQ+   
Sbjct: 58  VVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGT 117

Query: 745 EFEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPD 804
           E  + + P  +      L+   E    +  D  +  + +EG   L  L+   +    S  
Sbjct: 118 ELAETELPDDIPSIEEILAIRAERYHLLKND--ITAVTKEGKILLTNLEVPDTEGAVSSR 175

Query: 805 VRSH--LAAATALYSLVDEQLHVLVTASNSLLGKLELRV 841
           +  H  ++      + +  Q+H + TA +    K +L++
Sbjct: 176 LECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKM 214


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 84/388 (21%), Positives = 136/388 (35%), Gaps = 35/388 (9%)

Query: 202 GPLPLEALDLSSPQELHQASS---PDNQVLPAQSLAKGKGRTYGSKYPGLIKVEQARCGE 258
           GPL  + L +S+ + + +  +   P    L A +     G T G+  P + +  +A   E
Sbjct: 127 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186

Query: 259 VAFRMDEVVSQD---FEGDYVALLGFSQESRGE-SPSREAGTSSGCTSGALEEIAGTKET 314
           V        ++     EG   ++   S+ S  E SP+     S+G   G L+  A     
Sbjct: 187 VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG---GGLQRPASRS-- 241

Query: 315 PLFQKILPLSE-ANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSER---PPQ 370
            L     PLS  A  GPS           S+ +P  L   R   +  P  ++     P  
Sbjct: 242 -LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS 300

Query: 371 GSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASP 430
            S +     +    S     +   P +S +   L  P  +    P P    S +  P+ P
Sbjct: 301 SSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP--PSPSAPPSLQTLPSPP 358

Query: 431 AAAASETKIEVKT---KERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPE 487
           A   S+    + +   +  +  LP P P     T  P+ P P L    L+    P  +P 
Sbjct: 359 ATPPSQATTSLGSPTLQATHSFLPSP-PLSPLATPPPQAP-PALALPPLQAPPSPPASPP 416

Query: 488 KASLQHNGPWK-------VLCSLYSPKPNRAK----SLGKAGTTQTKTSGPATAPSPLTE 536
            + L    P         +L + +SP P+       S   +       + P+ AP  L  
Sbjct: 417 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAA 476

Query: 537 EKAALPEASAGSPERGPTLEEEPPGPEP 564
               +P +   SP   P+    P  P P
Sbjct: 477 PPLQVPPSPPASPPMSPSATPPPQAPPP 504



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 87/373 (23%), Positives = 132/373 (35%), Gaps = 77/373 (20%)

Query: 202 GPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGK----GRTYGSKYPGLIKVEQARCG 257
           GP         +P     AS    +  PA++ + G     GR  G+  PG +       G
Sbjct: 78  GPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL-------G 130

Query: 258 EVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTSSGCTSGALEEIAG-TKETPL 316
           +   R+                  ++E+     + EA   S  ++GA  + +G T  TP 
Sbjct: 131 QKGLRIS-----------------AEETVARGKATEAPKRSALSAGARRDTSGPTPGTP- 172

Query: 317 FQKILPLSEANEGPSLGNRACTKPE-SSEERPYNLGFRRKVNLKAPTHNSERPPQGSYMN 375
               +       G  +G     +P  S+  RP   G R+ V+  A  H++  P   +   
Sbjct: 173 -SPAMARRSRAAGTEVG---LPRPAPSARPRPPTEGPRKSVS-SASEHSTTEPSPAARRR 227

Query: 376 VLEDALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAAS 435
                     GL+   S+  ++S    PL +P      R GP    +PR +PA P+    
Sbjct: 228 P-----SAGGGLQRPASRSLSSSAT--PLSSPA-----RSGPSARGTPR-APAHPSQPKP 274

Query: 436 ETKIEVK----TKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSV--TPEKA 489
           +    ++    T  R    P   P  S   ++P P         L+ Q  P++  TP  +
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAA------LQSQAPPTLPATPHSS 328

Query: 490 SLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSP 549
           SL         C L +P P    S     + QT  S PAT PS  T         S GSP
Sbjct: 329 SLT--------CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAT--------TSLGSP 372

Query: 550 ERGPTLEEEPPGP 562
               T    P  P
Sbjct: 373 TLQATHSFLPSPP 385



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 49/184 (26%), Positives = 67/184 (36%), Gaps = 29/184 (15%)

Query: 386 GLRAGVSQEPAASKMQGPLGNPENMVQLRPGP-RQASSPRLSPAS--PAAAASETKIEVK 442
           G    V ++P A +  G  G        R GP R A +   +PAS  PA+   E     K
Sbjct: 48  GAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAK 107

Query: 443 TKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCS 502
                   P P+  P R + +  P   G K   LR   + +V   KA+            
Sbjct: 108 NTS-----PGPVSSPGRASGTTRPGPLGQKG--LRISAEETVARGKAT------------ 148

Query: 503 LYSPKPNRAKSLGKAGTTQTKTSGPATA-PSPLTEEKAALPEASAGSPERGPTLEEEPPG 561
             +PK    +S   AG  +  TSGP    PSP    ++       G P   P+    PP 
Sbjct: 149 -EAPK----RSALSAGARRD-TSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT 202

Query: 562 PEPR 565
             PR
Sbjct: 203 EGPR 206


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 40/168 (23%), Positives = 69/168 (41%), Gaps = 15/168 (8%)

Query: 389 AGVSQEPAASKM---QGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKE 445
           AG S  PA+ +      P   P      RP     SSP  +   P++   +   + K K 
Sbjct: 292 AGRSPSPASGRRGEGDAPFSEPGTTSTQRP-----SSPETATKQPSSPYEDKDKDKKEKS 346

Query: 446 RNGRLPKPMPCPSRNTSSPEPPTP-GLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLY 504
                 +P P P R+++ PEPP P  L      G  QP  T   +    N P +   +  
Sbjct: 347 AT----RPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRD 402

Query: 505 SPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERG 552
              P   + L ++ +++  +S P+  P+ ++   ++ PE+   +P  G
Sbjct: 403 RSPPKSPEKLPQSSSSE--SSPPSPQPTKVSRHASSSPESPKPAPAPG 448



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 40/197 (20%), Positives = 75/197 (38%), Gaps = 35/197 (17%)

Query: 391  VSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETK------------ 438
            V + PA++  Q     P  +  L+P   + SS   S +S ++++S +             
Sbjct: 2506 VGEPPASTGAQ----QPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS 2561

Query: 439  ------IEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQ 492
                  + V+ +    R+P P P P        PP P            P+    ++S  
Sbjct: 2562 DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEP-----------TPAKRKRRSSSS 2610

Query: 493  HNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERG 552
             +       S  S   + + S   + ++ + +S  +++PSP      ALP+ +  SP++ 
Sbjct: 2611 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPA--SPKKP 2668

Query: 553  PTLEEEPPGPEPRIGAL 569
            P  E     P   I +L
Sbjct: 2669 PPGERRSRSPRKPIDSL 2685



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 45/186 (24%), Positives = 70/186 (37%), Gaps = 22/186 (11%)

Query: 398 SKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMP-- 455
           SK +  L    ++    P P+Q S  +  P    + +S+ K + +T  R  R     P  
Sbjct: 767 SKAKSRLSLRRSLSGSSPCPKQKS--QTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPK 824

Query: 456 ----CPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPN-- 509
                PSR + S   P P +K       RQ S+T  +A+ Q   P +  C   SP P   
Sbjct: 825 QKSKTPSRQSHSSSSPHPKVKSG--TPPRQGSITSPQANEQSVTPQRRSCFESSPDPELK 882

Query: 510 ----RAKSLGKAGTTQTKTS-----GPATAPSPLTEEKAAL-PEASAGSPERGPTLEEEP 559
                  S   +   + K+S      P+ + SP  + KA + P   + S    P+     
Sbjct: 883 SRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVT 942

Query: 560 PGPEPR 565
               PR
Sbjct: 943 SRTTPR 948



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 45/200 (22%), Positives = 69/200 (34%), Gaps = 28/200 (14%)

Query: 385  SGLRAGVSQEPAASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKTK 444
            SG    V  +P A+  +   G+  +     P PR       S +S        +    T+
Sbjct: 1598 SGSSPEVKDKPRAAP-RAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTE 1656

Query: 445  ERNGRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLY 504
                  PK       + SSPEP T        R  R       KA L             
Sbjct: 1657 SSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLS------------ 1704

Query: 505  SPKPNRAKSLGKAGTTQTKT------SGPATAPSPLTEEKAALPEASAGSPERGPTLEE- 557
                 R++S   +  T+++T      S   ++P P  + +++    SA SP    T    
Sbjct: 1705 ----RRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRG 1760

Query: 558  EPPGPEPRIGALGVKVFRSR 577
              P P+PR    G++  RSR
Sbjct: 1761 RSPSPKPR----GLQRSRSR 1776



 Score = 31.2 bits (69), Expect = 6.2
 Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 56/415 (13%)

Query: 182  TSPEFVDDRPQVVNALCQAWGPLPLEALDLSSPQELHQAS--SPDNQVLPAQSLAKGKGR 239
            +SPE V++RP V   L Q+     LEA+++ S          SP+++ L    L +    
Sbjct: 1270 SSPE-VEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLREN--- 1325

Query: 240  TYGSKYPGLIKVEQARCGEVAFRMD----EVVSQDFEGDYVALLGF--SQESRGESPSRE 293
            ++GS       +E    G +   M+      V +D  G ++  L    S + + +S    
Sbjct: 1326 SFGSP------LEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSS 1379

Query: 294  AGTSSGCTSGALEEIAGTKETPLFQKIL---PLSEANEGPSLGNRACTKPESSEERPYNL 350
              +SS  +  A+E+   +    +   +L   P + + E  S    + + PE  +  P   
Sbjct: 1380 GHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSS----SASSPEMKDGLPRTP 1435

Query: 351  GFRRKVNLKAPTHNSERPPQGSYMNVLEDALDCASGLRAGVSQEPAASKMQGPLG-NPEN 409
              R +        +    P          +L  +S     + + P+  + +      P+ 
Sbjct: 1436 SRRSRSGSSPGLRDGSGTPS-------RHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKA 1488

Query: 410  MVQL-RPGPRQASSPRLS----PASPAAAASETKIEVKT--------KERNGRLP----K 452
            + Q  RP  R  SSP L+          + SE+ ++ KT        + R+G       K
Sbjct: 1489 LPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVK 1548

Query: 453  PMPCPSRNTSSPEPPTPGLKFSF-LRGQRQPSVTPEKASLQHNGPWKVLCSLYSP----K 507
            P   P   + S   P    K    LR + +   +PE  S     P +   S  SP    K
Sbjct: 1549 PSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-SGSSPEVKDK 1607

Query: 508  PNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGP 562
            P  A        +  +   PA    P      +  +    SPE   + E  P  P
Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP 1662



 Score = 30.8 bits (68), Expect = 8.1
 Identities = 42/175 (24%), Positives = 62/175 (35%), Gaps = 27/175 (15%)

Query: 414  RPGPRQASSPRLSPASPAAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGLKF 473
            R  PR   SP +S   PA  +  ++     + R+   P+     SR   SP P   GL+ 
Sbjct: 1719 RTPPRHRRSPSVSSPEPAEKSRSSR-----RRRSASSPRTKTT-SRRGRSPSPKPRGLQR 1772

Query: 474  SFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSP 533
            S  R +R+ + T  +             S  S    R +S  ++  T+ +  G     S 
Sbjct: 1773 SRSRSRREKTRTTRRRDRSG--------SSQSTSRRRQRSRSRSRVTRRRRGG-----SG 1819

Query: 534  LTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKVFRSRIACLPGGRDRA 588
                  A  E+S  S  R       PP    R         RSR +  P  R R+
Sbjct: 1820 YHSRSPARQESSRTSSRRRRGRSRTPPTSRKR--------SRSRTSPAPWKRSRS 1866


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 57/208 (27%), Positives = 76/208 (36%), Gaps = 32/208 (15%)

Query: 392 SQEPA---ASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKT-KERN 447
           SQ+PA   A +   P G P    Q  PGP++   P      P      + +         
Sbjct: 449 SQQPAGPPAQQRPPPQGGPP---QPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLP 505

Query: 448 GRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPK 507
            RLP P   P +  S   PPT G      +G++   V     +     P        SP 
Sbjct: 506 QRLPSPTSAPQQPASQAAPPTQG------QGRQSRPVAGGPGAPPAARP------PASPS 553

Query: 508 PNRAKSLGKAGTTQTKTSGP----ATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPE 563
           P R     +A T QT  SGP    A+   P  +++   P+   G    GPT +    GP 
Sbjct: 554 PQRQAGPPQA-TRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPG--PAGPTRQASQAGPV 610

Query: 564 PRIGALGVKVFRSRIACLPGGRDRAGRP 591
           PR G    +  R      P G   AGRP
Sbjct: 611 PRTGPPTTQQPR------PSGPGPAGRP 632


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 57/208 (27%), Positives = 76/208 (36%), Gaps = 32/208 (15%)

Query: 392 SQEPA---ASKMQGPLGNPENMVQLRPGPRQASSPRLSPASPAAAASETKIEVKT-KERN 447
           SQ+PA   A +   P G P    Q  PGP++   P      P      + +         
Sbjct: 449 SQQPAGPPAQQRPPPQGGPP---QPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLP 505

Query: 448 GRLPKPMPCPSRNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPK 507
            RLP P   P +  S   PPT G      +G++   V     +     P        SP 
Sbjct: 506 QRLPSPTSAPQQPASQAAPPTQG------QGRQSRPVAGGPGAPPAARP------PASPS 553

Query: 508 PNRAKSLGKAGTTQTKTSGP----ATAPSPLTEEKAALPEASAGSPERGPTLEEEPPGPE 563
           P R     +A T QT  SGP    A+   P  +++   P+   G    GPT +    GP 
Sbjct: 554 PQRQAGPPQA-TRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPG--PAGPTRQASQAGPV 610

Query: 564 PRIGALGVKVFRSRIACLPGGRDRAGRP 591
           PR G    +  R      P G   AGRP
Sbjct: 611 PRTGPPTTQQPR------PSGPGPAGRP 632


>gi|55741655 anoctamin 8 [Homo sapiens]
          Length = 1232

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 62/251 (24%), Positives = 88/251 (35%), Gaps = 38/251 (15%)

Query: 323  LSEANEGPSLGNRACTKPESSEER-PYNLGFR--RKVNLKAPTHNSERPPQGSYMNVLED 379
            L+ A  G +        P  S+ R P  L F+  +    +  +  S  PP+  +   L  
Sbjct: 997  LAAAGAGATTRPPPAQSPTGSDTRLPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFP 1056

Query: 380  ALDCASGLRAGVSQEPAASKMQGPLGNPENMVQLRP-GPRQASSPRLSPASPA--AAASE 436
                      G   EP ++   G         Q RP G   + S R+  + P   A A E
Sbjct: 1057 F--------GGTRAEPGSNGAGG---------QARPDGTPSSGSSRVQRSGPVDEALAEE 1099

Query: 437  TKIEVKTKERNGRLPKPMPCPS---RNTSSPEPPTPGLKFSFLRGQRQPSVTPEKASLQH 493
             +     +E +G    P+  P+   R + SP PP P      +   R P  TP     Q 
Sbjct: 1100 LEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPP------MPLPRPP--TPPAGCWQW 1151

Query: 494  NGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSGPATAPSPLTEEKAALPEASAGSPERGP 553
            +GPW   C      P +A  L  A       +GP  AP PL  + +         P    
Sbjct: 1152 DGPWG--CGGEGAAPRQA--LAAAECPPCAMAGPPPAPQPLPGDASFYSLPPPPLPPTSD 1207

Query: 554  TLEEEPPGPEP 564
             LE   P P P
Sbjct: 1208 PLETPAPSPSP 1218


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,543,183
Number of Sequences: 37866
Number of extensions: 3067490
Number of successful extensions: 15276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 498
Number of HSP's that attempted gapping in prelim test: 13706
Number of HSP's gapped (non-prelim): 1931
length of query: 1200
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1086
effective length of database: 13,930,794
effective search space: 15128842284
effective search space used: 15128842284
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.