Search of human proteins with 71274107

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
         (646 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71274107 melanoma cell adhesion molecule [Homo sapiens]           1300   0.0  
gi|31543106 basal cell adhesion molecule isoform 1 precursor [Ho...   223   4e-58
gi|61742797 basal cell adhesion molecule isoform 2 precursor [Ho...   213   6e-55
gi|68163411 activated leukocyte cell adhesion molecule [Homo sap...   174   2e-43
gi|166295173 kin of IRRE like [Homo sapiens]                           87   5e-17
gi|118572606 hemicentin 1 [Homo sapiens]                               86   1e-16
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             77   6e-14
gi|19743806 roundabout 1 isoform b [Homo sapiens]                      76   1e-13
gi|224994173 roundabout 1 isoform d [Homo sapiens]                     75   1e-13
gi|224994171 roundabout 1 isoform c [Homo sapiens]                     75   1e-13
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...    75   1e-13
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...    75   1e-13
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]               73   7e-13
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]                73   7e-13
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    72   2e-12
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    72   2e-12
gi|4506569 roundabout 1 isoform a [Homo sapiens]                       71   3e-12
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    71   4e-12
gi|10835203 advanced glycosylation end product-specific receptor...    70   5e-12
gi|13489095 sialoadhesin precursor [Homo sapiens]                      70   5e-12
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    70   6e-12
gi|109150416 peroxidasin [Homo sapiens]                                70   8e-12
gi|21686977 cell adhesion molecule 4 [Homo sapiens]                    70   8e-12
gi|26787962 advanced glycosylation end product-specific receptor...    69   1e-11
gi|110349719 titin isoform N2-A [Homo sapiens]                         69   2e-11
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         68   2e-11
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...    68   2e-11
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...    68   2e-11
gi|18201909 vascular cell adhesion molecule 1 isoform b precurso...    68   3e-11
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...    67   4e-11

>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
          Length = 646

 Score = 1300 bits (3363), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV 60
           MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV
Sbjct: 1   MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV 60

Query: 61  DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR 120
           DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR
Sbjct: 61  DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR 120

Query: 121 PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP 180
           PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP
Sbjct: 121 PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP 180

Query: 181 LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE 240
           LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE
Sbjct: 181 LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE 240

Query: 241 VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN 300
           VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN
Sbjct: 241 VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN 300

Query: 301 DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS 360
           DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS
Sbjct: 301 DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS 360

Query: 361 LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT 420
           LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT
Sbjct: 361 LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT 420

Query: 421 QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV 480
           QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV
Sbjct: 421 QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV 480

Query: 481 LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH 540
           LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH
Sbjct: 481 LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH 540

Query: 541 TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL 600
           TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL
Sbjct: 541 TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL 600

Query: 601 PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH 646
           PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH
Sbjct: 601 PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH 646


>gi|31543106 basal cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 628

 Score =  223 bits (568), Expect = 4e-58
 Identities = 195/676 (28%), Positives = 302/676 (44%), Gaps = 97/676 (14%)

Query: 2   GLPRLVC-AFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV 60
           G PRL+  A LLAA            E     P LVEV  G + +L C  + +  +   +
Sbjct: 12  GAPRLLLLAVLLAAH------PDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYM-L 64

Query: 61  DWF------------SVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTP 108
           +WF            S   +   L   +   +G+S P + + +         L L +   
Sbjct: 65  EWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQ-------GRLVLAEAQV 117

Query: 109 QDERIFLC--QGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNG 166
            DER ++C  +     + E   +L V+  PE   +  N   + V     +E+ATC  RNG
Sbjct: 118 GDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNG 177

Query: 167 YPIPQVIWYKNGRPLK--EEKNRVHIQSSQTV-ESSGLYTLQSILKAQLVKEDKDAQFYC 223
            P P++ WY+NG+ L+   E N     +S+TV E+SGL +L S L  +L K+D+DA F+C
Sbjct: 178 NPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHC 237

Query: 224 ELNYRLPSGNHMK-ESREVTVPVFYPTEKVWLEV----EPVGMLKEGDRVEIRCLADGNP 278
             +Y LP G H + +S    + + YPTE V   V     P G ++EGD V++ C  DG+P
Sbjct: 238 AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSP 297

Query: 279 PPHFSISKQNPSTREAEEETTNDN--GVLVLEPARKEHSGRYECQGLDLDTMISL-LSEP 335
            P +++ +     ++ +EE  N N  G L LE   +  SG Y C+  D D    + LS+ 
Sbjct: 298 SPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKT 353

Query: 336 QELLVNYVSDVRVSPA-APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQL 394
            EL V Y+  + +S          SS  + C          +W ++ T   L  GP+L L
Sbjct: 354 LELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST--PLGDGPMLSL 411

Query: 395 HDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERK-----VWVKENMVLN 449
             +  ++ G Y C AS+P++P L+RTQ   + + G P +   E +      W +E   + 
Sbjct: 412 SSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSW-REGDEVT 470

Query: 450 LSCEASGHPRPTISWNVNGTASEQDQDPQR---VLSTLNVLVTPELLETGVECTASNDLG 506
           L C A GHP P +SW+  G  S  +  P R   V S+L + VT  L   G+ C ASN  G
Sbjct: 471 LICSARGHPDPKLSWSQLG-GSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529

Query: 507 KNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVI 566
               +     V+                                  P+    GV ++AV 
Sbjct: 530 NKRHVFHFGTVS----------------------------------PQTSQAGVAVMAVA 555

Query: 567 VCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLLQG 626
           V + +L ++ AV Y + +KG  PC R  +++   PP    E  +     + PE+ GLL G
Sbjct: 556 VSVGLLLLVVAVFYCVRRKGG-PCCRQRREKGAPPP---GEPGLSHSGSEQPEQTGLLMG 611

Query: 627 --SSGDKRAPGDQGEK 640
             S G +   G  G++
Sbjct: 612 GASGGARGGSGGFGDE 627


>gi|61742797 basal cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 588

 Score =  213 bits (541), Expect = 6e-55
 Identities = 181/626 (28%), Positives = 280/626 (44%), Gaps = 91/626 (14%)

Query: 2   GLPRLVC-AFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV 60
           G PRL+  A LLAA            E     P LVEV  G + +L C  + +  +   +
Sbjct: 12  GAPRLLLLAVLLAAH------PDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYM-L 64

Query: 61  DWF------------SVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTP 108
           +WF            S   +   L   +   +G+S P + + +         L L +   
Sbjct: 65  EWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQ-------GRLVLAEAQV 117

Query: 109 QDERIFLC--QGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNG 166
            DER ++C  +     + E   +L V+  PE   +  N   + V     +E+ATC  RNG
Sbjct: 118 GDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNG 177

Query: 167 YPIPQVIWYKNGRPLK--EEKNRVHIQSSQTV-ESSGLYTLQSILKAQLVKEDKDAQFYC 223
            P P++ WY+NG+ L+   E N     +S+TV E+SGL +L S L  +L K+D+DA F+C
Sbjct: 178 NPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHC 237

Query: 224 ELNYRLPSGNHMK-ESREVTVPVFYPTEKVWLEV----EPVGMLKEGDRVEIRCLADGNP 278
             +Y LP G H + +S    + + YPTE V   V     P G ++EGD V++ C  DG+P
Sbjct: 238 AAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSP 297

Query: 279 PPHFSISKQNPSTREAEEETTNDN--GVLVLEPARKEHSGRYECQGLDLDTMISL-LSEP 335
            P +++ +     ++ +EE  N N  G L LE   +  SG Y C+  D D    + LS+ 
Sbjct: 298 SPEYTLFR----LQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKT 353

Query: 336 QELLVNYVSDVRVSPA-APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQL 394
            EL V Y+  + +S          SS  + C          +W ++ T   L  GP+L L
Sbjct: 354 LELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDST--PLGDGPMLSL 411

Query: 395 HDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERK-----VWVKENMVLN 449
             +  ++ G Y C AS+P++P L+RTQ   + + G P +   E +      W +E   + 
Sbjct: 412 SSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSW-REGDEVT 470

Query: 450 LSCEASGHPRPTISWNVNGTASEQDQDPQR---VLSTLNVLVTPELLETGVECTASNDLG 506
           L C A GHP P +SW+  G  S  +  P R   V S+L + VT  L   G+ C ASN  G
Sbjct: 471 LICSARGHPDPKLSWSQLG-GSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHG 529

Query: 507 KNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVI 566
               +     V+                                  P+    GV ++AV 
Sbjct: 530 NKRHVFHFGTVS----------------------------------PQTSQAGVAVMAVA 555

Query: 567 VCILVLAVLGAVLYFLYKKGKLPCRR 592
           V + +L ++ AV Y + +KG   CR+
Sbjct: 556 VSVGLLLLVVAVFYCVRRKGGPCCRQ 581


>gi|68163411 activated leukocyte cell adhesion molecule [Homo
           sapiens]
          Length = 583

 Score =  174 bits (441), Expect = 2e-43
 Identities = 143/583 (24%), Positives = 260/583 (44%), Gaps = 59/583 (10%)

Query: 41  GSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQS----EPGEYEQRLSLQD 96
           G T ++ C L   Q NL    W     +   +    R    +S    +  EY+ RL+L +
Sbjct: 36  GDTIIIPCRLDVPQ-NLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSE 94

Query: 97  RGATLALTQVTPQDERIFLCQ-GKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEP 155
              TL+++     DE+ F+C         E    ++V+K P +P I    L +   +++ 
Sbjct: 95  N-YTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFL--ETEQL 151

Query: 156 EEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES-SGLYTLQSILKAQLVK 214
           +++  C+  + YP   + WY+NG+ L   +  V I   + ++  + LYT+ S L+ +  K
Sbjct: 152 KKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTK 211

Query: 215 EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEV-EPVGMLKEGDRVEIRCL 273
            D    F C + Y  PSG     S +    ++YPTE+V ++V  P   +KEGD + ++CL
Sbjct: 212 ADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCL 271

Query: 274 ADGNPPPH---FSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMIS 330
            +GNPPP    F +  Q    R +   T  D         R+  +G Y+C  +D  +MI+
Sbjct: 272 GNGNPPPEEFLFYLPGQPEGIRSSNTYTLTD--------VRRNATGDYKCSLIDKKSMIA 323

Query: 331 LLSEPQELLVNYVSDVRVSPAAP-ERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERG 389
             +    + V+Y+ D+ ++P+    RQ G +L ++C   +S++    W+++     L   
Sbjct: 324 STA----ITVHYL-DLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIR--LRSS 376

Query: 390 PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLN 449
           P      L  +  G Y C  ++  + GL + + + + + G P    K  K      +   
Sbjct: 377 P--SFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKP--QIKMTKKTDPSGLSKT 432

Query: 450 LSCEASGHPRPTISWNVNGTASEQDQDPQRVLST----LNVLVTPELLETGVECTASNDL 505
           + C   G P+P I W + G+ S  +Q  +           ++++PE   T + CTA N L
Sbjct: 433 IICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVT-LTCTAENQL 491

Query: 506 GKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAV 565
            +  + L                   +S  +   H  A+  S E +  +   +  +IV +
Sbjct: 492 ERTVNSL------------------NVSAISIPEHDEADEISDENR-EKVNDQAKLIVGI 532

Query: 566 IVCILVLAVLGAVLYFLY-KKGKLPCRRSGKQEITLPPSRKSE 607
           +V +L+ A++  V+Y+LY KK K   +   K    +  ++K E
Sbjct: 533 VVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLE 575


>gi|166295173 kin of IRRE like [Homo sapiens]
          Length = 757

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 143/600 (23%), Positives = 229/600 (38%), Gaps = 98/600 (16%)

Query: 28  AEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGE 87
           +++PA + V    G  A+L C L    G    V W    K+   L      GQG      
Sbjct: 24  SQEPADQTVVA--GQRAVLPCVLLNYSGI---VQWT---KDGLAL----GMGQGLKAWPR 71

Query: 88  YEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLG 147
           Y    S       L +T     D+  + CQ      +  R +L V   PE+  I   P+ 
Sbjct: 72  YRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPV- 130

Query: 148 IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
           I + +  P  + TC   N  P   +IW+++G      +    + S++ ++     T  S 
Sbjct: 131 ILLQAGTPHNL-TCRAFNAKPAATIIWFRDGT-----QQEGAVASTELLKDGKRETTVSQ 184

Query: 208 LKAQLVKEDKDAQFYCE-LNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
           L       D    F C  +N  +PSG       +V  P   PT  V L +EP   ++EG+
Sbjct: 185 LLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP---PT--VTLSIEPQ-TVQEGE 238

Query: 267 RVEIRCLADGNPPP-HFSISKQNPSTREAEEET--TNDNGVLVLEPARKEHSGRYECQGL 323
           RV   C A  NP    +  +K      +A E    TN +     EP   E   +      
Sbjct: 239 RVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVG--ST 296

Query: 324 DLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG 383
           ++ T+++         V++   + V P       GS +TLTC    +  L   W ++++ 
Sbjct: 297 NVSTLVN---------VHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSN 347

Query: 384 QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
            VL     L L  + +   G Y C A VP I    R   V + + GPP ++ +  +  V+
Sbjct: 348 MVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE--VPLYVNGPPIISSEAVQYAVR 405

Query: 444 ENMVLNLSCEASGHPRP---TISWNVN----GTAS----EQDQDPQRVLSTLNVLVTPEL 492
            +    + C     P P     +W  N    GT      E+      VLSTL +    E 
Sbjct: 406 GDGG-KVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEA 464

Query: 493 -LETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERK 551
             +T   CTA N  G  T+I+ LE   +  +   +  T G S                  
Sbjct: 465 DFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS------------------ 506

Query: 552 LPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVE 611
                            IL++    A+++FLY++     R+  ++++TL   RK ++ VE
Sbjct: 507 -----------------ILLIFFFIALVFFLYRR-----RKGSRKDVTL---RKLDIKVE 541


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 118/451 (26%), Positives = 181/451 (40%), Gaps = 72/451 (15%)

Query: 90   QRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRI-QLRVYKAPEEPNIQVNPLGI 148
            +R+ +   G+TL +      D   + C    P  +E RI  L VY  P           I
Sbjct: 3293 ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT----------I 3342

Query: 149  PVNSKEPEEVATCVGRN--------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSG 200
              N  E E++ T V  +        G P PQ+ W KNG PL    +   + + Q +    
Sbjct: 3343 RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIR--- 3399

Query: 201  LYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTE-KVWLEVEPV 259
                  I++AQ+      A + C  + R    N     +   + VF P      +  E +
Sbjct: 3400 ------IVRAQV---SDVAVYTCVASNRAGVDN-----KHYNLQVFAPPNMDNSMGTEEI 3445

Query: 260  GMLKEGDRVEIRCLADGNPPPHFS-ISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRY 318
             +LK G    + C+ DG P P  + +    P   +A    +    VL L  A  E SG+Y
Sbjct: 3446 TVLK-GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKY 3504

Query: 319  ECQGLDLDTMISLLSEPQELLVNYVSDVRVSP---AAPERQE-----GSSLTLTCEAESS 370
             C            +E  E+  +++  V   P    + E +E      + L LTC A   
Sbjct: 3505 TC---------IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGI 3555

Query: 371  QDLEFQWLRE-----ETGQV--LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLV 423
               +  W+++     +T QV  L  G VL++   + E  G Y C+AS P+    ++  LV
Sbjct: 3556 PAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEYLV 3614

Query: 424  NVAIFGPPWMAFKE--RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL 481
             V +  PP +A  +  R + V  N  + L C++   P P I+W  NG    Q     R+L
Sbjct: 3615 RVHV--PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL-QATPRVRIL 3671

Query: 482  STLNVLV--TPELLET-GVECTASNDLGKNT 509
            S    L     +L +T    C ASN  GK T
Sbjct: 3672 SGGRYLQINNADLGDTANYTCVASNIAGKTT 3702



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 93/411 (22%), Positives = 164/411 (39%), Gaps = 63/411 (15%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQGKR---PRSQEYRIQLRVYKAPEEPNIQVNPLGI 148
            LS+ +  + L +     QD   + C+         + Y + + V      PNI  +    
Sbjct: 2150 LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWV-----PPNIGGSDELT 2204

Query: 149  PVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP-LKEEKNRVHIQSS--------QTVESS 199
             +   E   ++     +G P P +IW K G P L +   RV I S              +
Sbjct: 2205 QLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDA 2264

Query: 200  GLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPV 259
             LY+  +   A   K++ + Q Y        SG+H             PTE +       
Sbjct: 2265 ALYSCVASNVAGTAKKEYNLQVYIRPTIT-NSGSH-------------PTEII------- 2303

Query: 260  GMLKEGDRVEIRCLADGNPPPHFSISKQ-NPSTREAEEETTNDNGVLVLEPARKEHSGRY 318
              +  G  + + C   G PPP  +  K  +P  +    E  ++  +L L+      +GRY
Sbjct: 2304 --VTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRY 2361

Query: 319  ECQGLDLDTMISL-----LSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDL 373
             C  +++  M        +  P  ++ N+ S   +S       E +S++LTCEA      
Sbjct: 2362 VCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVV-----EKNSVSLTCEASGIPLP 2416

Query: 374  EFQWLRE-------ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVA 426
               W ++        + ++L  G +L+L     E  G Y CV  V +  G  R ++  ++
Sbjct: 2417 SITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCV--VRNAAGEER-KIFGLS 2473

Query: 427  IFGPPWMAFKE--RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQ 475
            +  PP +  +     V VKE   + L+CE +G+P P I+W+ +G   ++D+
Sbjct: 2474 VLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE 2524



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 96/393 (24%), Positives = 158/393 (40%), Gaps = 56/393 (14%)

Query: 100  TLALTQVTPQDERIFLCQGKR-PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEV 158
            TL++ Q TP D  I+ C       + E  I L V + P      V  L  P N+   E V
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPT-----VEDLEPPYNTTFQERV 1279

Query: 159  AT------CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL 212
            A       C  + G P P + W  NGR L   +  + I     +E   L  + S+     
Sbjct: 1280 ANQRIEFPCPAK-GTPKPTIKWLHNGRELTGREPGISI-----LEDGTLLVIASVTPYD- 1332

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRC 272
                 + ++ C +          K + +V VP   P  K   +V  V +L       + C
Sbjct: 1333 -----NGEYIC-VAVNEAGTTERKYNLKVHVP---PVIKDKEQVTNVSVLLN-QLTNLFC 1382

Query: 273  LADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLEPARKEHSGRYECQGLDLDTM--- 328
              +G P P     K N    E+   +T N+  +L L  A  E +GRY C+ +++      
Sbjct: 1383 EVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQK 1442

Query: 329  ---ISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQW-------- 377
               I +L  P  +  N+ ++V V            + L C+ + +   +  W        
Sbjct: 1443 YFNIDVLVPPTIIGTNFPNEVSV-------VLNRDVALECQVKGTPFPDIHWFKDGKPLF 1495

Query: 378  LREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM--AF 435
            L +   ++L+RG VL L + +R   G Y+C  +V +  G  + + + + I+ PP +    
Sbjct: 1496 LGDPNVELLDRGQVLHLKNARRNDKGRYQC--TVSNAAG-KQAKDIKLTIYIPPSIKGGN 1552

Query: 436  KERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
                + V  N ++ L CE  G P P I+W  +G
Sbjct: 1553 VTTDISVLINSLIKLECETRGLPMPAITWYKDG 1585



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 104/463 (22%), Positives = 181/463 (39%), Gaps = 58/463 (12%)

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQV 143
            +P   +  L++   G  L L +   +D   + C       +  +  +     P   N   
Sbjct: 3474 QPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSE 3533

Query: 144  NPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKN-------RVHIQSSQTV 196
                I V    P E+ TC+  +G P P++ W K+GRPL +           V   S+  V
Sbjct: 3534 EHEEISVIVNNPLEL-TCIA-SGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQV 3591

Query: 197  ESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEV 256
            E +G YT  +   A     D D ++   ++   P+     E R++TV             
Sbjct: 3592 EDTGRYTCLASSPAG----DDDKEYLVRVHVP-PNIAGTDEPRDITV------------- 3633

Query: 257  EPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHS 315
                      +V + C +D  PPP  +  +     +          G  L +  A    +
Sbjct: 3634 ------LRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDT 3687

Query: 316  GRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEF 375
              Y C   ++       +    L VN   +++  P +       S  L C AE       
Sbjct: 3688 ANYTCVASNI---AGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRI 3744

Query: 376  QWLREETG--------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
             W ++            +LE G  L +        G Y C+A+  +  G +R + +++ +
Sbjct: 3745 TWRKDGAVLAGNHARYSILENG-FLHIQSAHVTDTGRYLCMAT--NAAGTDRRR-IDLQV 3800

Query: 428  FGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG--TASEQDQDPQRVLSTLN 485
              PP +A     + V  N+   L+CEA+G P+P+I+W  NG     +Q+Q+  R+LS+ +
Sbjct: 3801 HVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGS 3860

Query: 486  -VLVTPELLETGV-ECTASNDLGKNTSILFLELVNLTTLTPDS 526
             V+++P + +T   ECT +N  G +        V+LT   P S
Sbjct: 3861 LVIISPSVDDTATYECTVTNGAGDDK-----RTVDLTVQVPPS 3898



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 107/450 (23%), Positives = 173/450 (38%), Gaps = 67/450 (14%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPEEPNIQVNPLGIPV 150
            + + D G  L L  +   D   ++C         + +  L V+  P       +P  I V
Sbjct: 2339 VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISV 2398

Query: 151  NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKA 210
              K    + TC   +G P+P + W+K+G P       V + +S  + S G      +L+ 
Sbjct: 2399 VEKNSVSL-TCEA-SGIPLPSITWFKDGWP-------VSLSNSVRILSGG-----RMLRL 2444

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLEVEPVGMLKEGDRVE 269
                 +   Q+ C +  R  +G   K     V VP     E    +V+    +KE   V 
Sbjct: 2445 MQTTMEDAGQYTCVV--RNAAGEERKIFGLSVLVPPHIVGENTLEDVK----VKEKQSVT 2498

Query: 270  IRCLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTM 328
            + C   GNP P  +  K     +E E       G  L +   +  H+GRY C        
Sbjct: 2499 LTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC-------- 2550

Query: 329  ISLLSEPQ-ELLVNYVSDVRVSPAA--------PERQE---GSSLTLTCEAESSQDLEFQ 376
              L S P      ++  +V VSP          PE       S  +L CEA S       
Sbjct: 2551 --LASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATIT 2608

Query: 377  WLREETG-------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFG 429
            W ++ T        ++L  G  LQ+ + + +  G Y CVA+  +   +   +   V ++ 
Sbjct: 2609 WFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYE---VKVYI 2665

Query: 430  PPWM--------AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL 481
            PP +            ++V +K N  L L CEA   P  ++SW  +G   + D D   + 
Sbjct: 2666 PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-DHVNIA 2724

Query: 482  STLNVLVTPE--LLETG-VECTASNDLGKN 508
            +  + L   E  + +TG   C ASN  G++
Sbjct: 2725 ANGHTLQIKEAQISDTGRYTCVASNIAGED 2754



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 95/401 (23%), Positives = 155/401 (38%), Gaps = 67/401 (16%)

Query: 98   GATLALTQVTPQDERIFLCQG-KRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPE 156
            G TL + +    D   + C    +    + +  L VY  P   +     L + VN +E  
Sbjct: 3017 GRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSV-VNVREGT 3075

Query: 157  EVATCVGRNGYPIPQVIWYKNGRPLKE--------EKNRVHIQSSQTVESSGLYTLQSIL 208
             V+     N  P P + WYKNGR + E        +   +HI+ ++ V  +G Y  ++I 
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAE-VSDTGQYVCRAIN 3134

Query: 209  KAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRV 268
             A   ++DK+      LN  +P      E REV V                      + V
Sbjct: 3135 VAG--RDDKN----FHLNVYVPPSIEGPE-REVIVETI------------------SNPV 3169

Query: 269  EIRCLADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLEPARKEH--SGRYECQGLDL 325
             + C A G PPP  +  K +     ++  E    +G   L+ AR +H  SG Y C   ++
Sbjct: 3170 TLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNM 3229

Query: 326  D------TMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLR 379
            +        +S+   P        SDV V         G ++ L C A        QWL+
Sbjct: 3230 EGKAQKYYFLSIQVPPSVAGAEIPSDVSV-------LLGENVELVCNANGIPTPLIQWLK 3282

Query: 380  E---------ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
            +         E  +V   G  L ++       G Y CVA+ P+       ++ N+ ++  
Sbjct: 3283 DGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPA---GEEDRIFNLNVYVT 3339

Query: 431  PWMAFKE---RKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
            P +   +    K+    +  +N+ C A+G P P I+W  NG
Sbjct: 3340 PTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG 3380



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 118/532 (22%), Positives = 204/532 (38%), Gaps = 76/532 (14%)

Query: 28   AEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGE 87
            A    PE V V V  +AL++C  S S    +   W               Q  GQ    +
Sbjct: 2874 ANSDLPEEVTVLVNKSALIECLSSGSPAPRN--SW---------------QKDGQPLLED 2916

Query: 88   YEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLG 147
               +     R   +  TQ+T     + + +     +++Y   L V+  P     +   L 
Sbjct: 2917 DHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKY-FNLNVHVPPSVIGPKSENLT 2975

Query: 148  IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
            + VN+     ++     +G+P P + W KN +P+K   N + +   +T++         I
Sbjct: 2976 VVVNNF----ISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQ---------I 3022

Query: 208  LKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDR 267
            ++A   K     ++ C     +      K+   +TV V    +    E   V  ++EG  
Sbjct: 3023 IRA---KVSDGGEYTC---IAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTS 3076

Query: 268  VEIRCLADGNPPPHFSISKQNPS-TREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLD 326
            V + C ++  PPP  +  K     T     E   D  +L ++ A    +G+Y C+ +++ 
Sbjct: 3077 VSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVA 3136

Query: 327  TMISLLSEPQELLVNYVSDVRVSPA--APERQE-----GSSLTLTCEAESSQDLEFQWLR 379
                          N+  +V V P+   PER+       + +TLTC+A         WL+
Sbjct: 3137 GRDD---------KNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLK 3187

Query: 380  EETG---------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
                         ++L  G  LQ+   +    G Y C+AS  ++ G    +   ++I  P
Sbjct: 3188 NHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIAS--NMEG-KAQKYYFLSIQVP 3244

Query: 431  PWMAFKE----RKVWVKENMVLNLSCEASGHPRPTISWNVNG-TASEQDQDPQRVL---S 482
            P +A  E      V + EN  + L C A+G P P I W  +G   +  + +  RV    S
Sbjct: 3245 PSVAGAEIPSDVSVLLGEN--VELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGS 3302

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLST 534
            TLN+            C A+N  G+   I  L +    T+  + +    L T
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMT 3354



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 101/456 (22%), Positives = 179/456 (39%), Gaps = 67/456 (14%)

Query: 66   HKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPR-SQ 124
            HK+ R ++  +RQ    S                +L +  V P D   + C       S 
Sbjct: 4113 HKDGRAIVESIRQRVLSS---------------GSLQIAFVQPGDAGHYTCMAANVAGSS 4157

Query: 125  EYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEE 184
                +L V+  P   + +    G    ++  + +  CV  +G P P + W K+   L   
Sbjct: 4158 STSTKLTVHVPPRIRSTE----GHYTVNENSQAILPCVA-DGIPTPAINWKKDNVLL--- 4209

Query: 185  KNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFY-CELNYRLPSGNHMKESREVTV 243
                ++    T E  G   L++++        +D+ FY C  N       H        +
Sbjct: 4210 ---ANLLGKYTAEPYGELILENVVL-------EDSGFYTCVANNAAGEDTHTVSLTVHVL 4259

Query: 244  PVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG 303
            P F        E+     L +G+++ + C A G P P  + +  N +   A  ++ N + 
Sbjct: 4260 PTF-------TELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNN-NIIPAHFDSVNGHS 4311

Query: 304  VLVLEPARKEHSGRYECQGLDLDTMISLLS-----EPQELLVNYVSDVRVSPAAPERQEG 358
             LV+E   KE SG Y C   +    +  +      EP     +Y S+  + P       G
Sbjct: 4312 ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNW-IEPL------G 4364

Query: 359  SSLTLTCEAESSQDLEFQWLR-----EETGQVLERGP-VLQLHDLKREAGGGYRCVASVP 412
             +  L CE +       QW R     E + ++ + G   L ++    E  G Y CVA+  
Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424

Query: 413  SIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASE 472
            +  G+    + ++ +  PP +  +  +  +     + L+C+A+G P+PTI+W+  G +  
Sbjct: 4425 A--GVVERSM-SLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSIS 4481

Query: 473  QDQDPQRVLSTLNVLVTPELLE--TGVECTASNDLG 506
             D D   VLS  ++ +     E  +  EC A N +G
Sbjct: 4482 WD-DRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 92/407 (22%), Positives = 160/407 (39%), Gaps = 73/407 (17%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQG-KRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV 150
            ++  +RG  + +      D  I+ C       + E    L+V+ AP       N + + V
Sbjct: 1967 MTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSN-NMVAVVV 2025

Query: 151  NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQS--------SQTVESSGLY 202
            N+    E   C  R G P P + W K+G P+    N + + S        S  +  +G Y
Sbjct: 2026 NNPVRLE---CEAR-GIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY 2081

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
            T  ++  A   + D D + Y   N        M E + V+V +                 
Sbjct: 2082 TCVAVNAAGEKQRDIDLRVYVPPNI-------MGEEQNVSVLI----------------- 2117

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQ-NPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
                 VE+ C +D  PPP  +  K  +P  ++     + +  VL +E A+ + +GRY C+
Sbjct: 2118 --SQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCE 2175

Query: 322  GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ--------EGSSLTLTCEAESSQDL 373
                 T ++  +E      NY  ++ V P              EG+ ++L CE+      
Sbjct: 2176 A----TNVAGKTEK-----NYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPP 2226

Query: 374  EFQW-------LREETGQV--LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVN 424
               W       L +  G+V  L  G  LQ+   ++     Y CVAS  ++ G  + +  N
Sbjct: 2227 NLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVAS--NVAGTAKKE-YN 2283

Query: 425  VAIFGPPWM---AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
            + ++  P +        ++ V     ++L CE  G P PT++W  +G
Sbjct: 2284 LQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDG 2330



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 87/402 (21%), Positives = 154/402 (38%), Gaps = 78/402 (19%)

Query: 98   GATLALTQVTPQDERIFLCQGKRP---RSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            G  L + Q    +  ++ C          +E+ + + V      P I+ + L   V  K 
Sbjct: 1787 GRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV-----PPTIKSSGLSERVVVKY 1841

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTV--------ESSGLYTLQS 206
                  C+  NG P P + W K+ +P+   +  + IQSS  V        E +G YT  +
Sbjct: 1842 KPVALQCIA-NGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVA 1900

Query: 207  ILKAQLVKEDKDAQFYCELNYRLP-----SGNHMKESREVTVPVFYPTEKVWLEVEPVGM 261
               A       + Q + +L+   P     +G  + E+  V+ PV                
Sbjct: 1901 TNAAG------ETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPV---------------- 1938

Query: 262  LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLV-LEPARKEHSGRYEC 320
                   ++ C A GNP P  +  K N     +   T  + G ++ +E A+   +G Y+C
Sbjct: 1939 -------QLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKC 1991

Query: 321  QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQE------GSSLTLTCEAESSQDLE 374
              ++      L          Y   V V+P+             + + L CEA       
Sbjct: 1992 VAINSAGATELF---------YSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPS 2042

Query: 375  FQWLREETG--------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVA 426
              WL++ +         QVL  G +L L   +    G Y CVA   +  G  + + +++ 
Sbjct: 2043 LTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAV--NAAG-EKQRDIDLR 2099

Query: 427  IFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
            ++ PP +  +E+ V V  +  + L C++   P PT++W  +G
Sbjct: 2100 VYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDG 2141



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 68/232 (29%), Positives = 100/232 (43%), Gaps = 29/232 (12%)

Query: 265  GDRVEIRCLADGNPPPHFSISKQNPSTR-EAEEETTNDNGVLVLEPARKEHSGRYECQGL 323
            G RV+I C A G P P  + SK   +   + E   +N +G L ++ A    +G Y C   
Sbjct: 1185 GQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVAT 1244

Query: 324  DL----DTMISL-LSEPQELLVNYVSDVR--VSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
            ++    +T I+L + EP       V D+    +    ER     +   C A+ +     +
Sbjct: 1245 NIAGTDETEITLHVQEPPT-----VEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIK 1299

Query: 377  WL---REETGQ-----VLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
            WL   RE TG+     +LE G +L +  +     G Y CVA   +  G    +  N+ + 
Sbjct: 1300 WLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEA--GTTERKY-NLKVH 1356

Query: 429  GPPWMAFKER--KVWVKENMVLNLSCEASGHPRPTISW---NVNGTASEQDQ 475
             PP +  KE+   V V  N + NL CE  G P P I W   NV  T S   Q
Sbjct: 1357 VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQ 1408



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 90/360 (25%), Positives = 144/360 (40%), Gaps = 44/360 (12%)

Query: 166  GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCEL 225
            G P P + W KNG  L  ++N    Q+S  + SSG   + S         D  A + C +
Sbjct: 3829 GIPKPSINWRKNGHLLNVDQN----QNSYRLLSSGSLVIIS------PSVDDTATYECTV 3878

Query: 226  NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML--KEGDRVEIRCLADGNPPPHFS 283
                 +     + R V + V  P     +  EP   L  K    V I C A G P P   
Sbjct: 3879 -----TNGAGDDKRTVDLTVQVPPS---IADEPTDFLVTKHAPAV-ITCTASGVPFPSIH 3929

Query: 284  ISKQNPSTR-EAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNY 342
             +K         +      +G + +   +  H+GRY C   +             L V+ 
Sbjct: 3930 WTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNA---AGSAHRHVTLHVHE 3986

Query: 343  VSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE--------ETGQVLERGPVLQL 394
               ++  P+       + + L CEA  +      W +E            VL  G  LQ+
Sbjct: 3987 PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG-LQI 4045

Query: 395  HDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEA 454
                RE  G Y CVA  P+   L + +L NV +  PP ++   ++  +  +  + LSCEA
Sbjct: 4046 SRAVREDAGTYMCVAQNPAGTALGKIKL-NVQV--PPVISPHLKEYVIAVDKPITLSCEA 4102

Query: 455  SGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETG----VECTASNDLGKNTS 510
             G P P I+W+ +G A   +   QRVLS+ ++ +    ++ G      C A+N  G +++
Sbjct: 4103 DGLPPPDITWHKDGRAI-VESIRQRVLSSGSLQIA--FVQPGDAGHYTCMAANVAGSSST 4159



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 105/468 (22%), Positives = 183/468 (39%), Gaps = 104/468 (22%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
            G  L L Q T +D   + C  +    +E +I       P  P+I        V  KE + 
Sbjct: 2439 GRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVP--PHIVGENTLEDVKVKEKQS 2496

Query: 158  VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDK 217
            V       G P+P++ W+K+G+PL+E++       +  + S G +     L+   V+   
Sbjct: 2497 VTLTCEVTGNPVPEITWHKDGQPLQEDE-------AHHIISGGRF-----LQITNVQVPH 2544

Query: 218  DAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPV--GMLKEGDRVEIR---- 271
              ++ C  +   P+G+   +SR  ++ VF         V P   G+  +G+  ++     
Sbjct: 2545 TGRYTCLASS--PAGH---KSRSFSLNVF---------VSPTIAGVGSDGNPEDVTVILN 2590

Query: 272  ------CLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLD 324
                  C A   PP   +  K                G  L +  A+++++GRY C   +
Sbjct: 2591 SPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATN 2650

Query: 325  LDTMISLLSEPQELLVNYVSDVRV--------------SPAAPERQEGSSLTLTCEAESS 370
                     E  E++ +Y   V +              SP   + +  ++LTL CEA + 
Sbjct: 2651 ---------EAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAI 2701

Query: 371  QDLEFQWLREETGQVLE---------RGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQ 421
                  W ++  GQ L+          G  LQ+ + +    G Y CVAS  +I G +   
Sbjct: 2702 PSASLSWYKD--GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS--NIAGEDELD 2757

Query: 422  L-VNVAIFGPPWMAFKERKVWVKENMV----------------LNLSCEASGHPRPTISW 464
              VN+ +  PP      +K+W   NM+                ++L CE +  P PT++W
Sbjct: 2758 FDVNIQV--PPSF----QKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTW 2811

Query: 465  NVNGTASEQDQDPQRVLSTLNVLVTP--ELLETG-VECTASNDLGKNT 509
              +G       D   +L    VL  P  ++ + G   C A N+ G+++
Sbjct: 2812 YKDGHPL-TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDS 2858



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 105/473 (22%), Positives = 175/473 (36%), Gaps = 82/473 (17%)

Query: 95   QDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            Q R   L +  +   D+  ++C+ +           +  K   E  + V  L  P+    
Sbjct: 846  QLRTGALFILNLWASDKGTYICEAEN----------QFGKIQSETTVTVTGLVAPLIGIS 895

Query: 155  PEEVATCVGRN---------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQ 205
            P       G+          G PIP+  W KN   L +           TV S G     
Sbjct: 896  PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYI-------TVRSDGS---- 944

Query: 206  SILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEG 265
              L  + V+     ++ C  +    + N         +P     +++   +E       G
Sbjct: 945  --LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIE-------G 995

Query: 266  DRVEIRCLADGNPPPHFSISKQNP--STREAEEETTNDNGVLVLEPARKEHSGRYECQGL 323
              V + C A GNP P    SK+    ST  A+     D  + V+ P  +E SG Y C   
Sbjct: 996  IPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEE-SGEYVCTAT 1054

Query: 324  DL------DTMISLLSEPQ----ELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDL 373
            +          +++   P+    +  ++    V +S  A     G  +TL CE +S    
Sbjct: 1055 NTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-----GEEVTLPCEVKSLPPP 1109

Query: 374  EFQWLREETGQVLERGP--------VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNV 425
               W +E T  +    P         +++ + +    G Y CVA+  +I G N TQ V +
Sbjct: 1110 IITWAKE-TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVAT--NIAG-NVTQAVKL 1165

Query: 426  AIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQD-----QDPQRV 480
             +  PP +    + + V+    +++ C A G P P I+W+  G+    D      +P   
Sbjct: 1166 NVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGT 1225

Query: 481  LSTLNVLVTPELLETGV-ECTASNDLGKNTSILFLELVNLTT---LTPDSNTT 529
            LS      TP   + G+  C A+N  G + + + L +    T   L P  NTT
Sbjct: 1226 LSIDQ--ATPS--DAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTT 1274



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 84/367 (22%), Positives = 144/367 (39%), Gaps = 60/367 (16%)

Query: 166  GYPIPQVIWYKNGRPLKEE-------KNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKD 218
            G P P ++W K+G+ + E          R  + +   V ++GLY   +   A        
Sbjct: 1760 GSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTA-------- 1811

Query: 219  AQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNP 278
                         G+H KE  EVTV V    +   L    V   K    V ++C+A+G P
Sbjct: 1812 -------------GDHKKEF-EVTVHVPPTIKSSGLSERVVVKYKP---VALQCIANGIP 1854

Query: 279  PPHFSISKQNPSTREAEEETTNDNGVLVLEPARK--EHSGRYECQGLDLDTMISLLSEPQ 336
             P  +  K +     A+      +   VL+ A+   E +GRY C         +   E Q
Sbjct: 1855 NPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC------VATNAAGETQ 1908

Query: 337  ELLVNYVSDVRVSPAAPERQEGSSLT-----LTCEAESSQDLEFQWLREE-------TGQ 384
            + +  +V +      A +    + L      L C+A  +      W ++        +  
Sbjct: 1909 QHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMT 1968

Query: 385  VLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLV-NVAIFGPPWMAFKERKVWVK 443
             L RG ++ +   +    G Y+CVA    I     T+L  ++ +   P ++     V V 
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVA----INSAGATELFYSLQVHVAPSISGSNNMVAVV 2024

Query: 444  ENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLS--TLNVLVTPELLETG-VECT 500
             N  + L CEA G P P+++W  +G+      +  +VLS   +  L + ++ +TG   C 
Sbjct: 2025 VNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCV 2084

Query: 501  ASNDLGK 507
            A N  G+
Sbjct: 2085 AVNAAGE 2091



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 95/463 (20%), Positives = 176/463 (38%), Gaps = 64/463 (13%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKR--PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSK 153
            + G  L L + TP+D   + C+       SQ+Y             NI V      + + 
Sbjct: 1411 NNGKILKLFRATPEDAGRYSCKAINIAGTSQKYF------------NIDVLVPPTIIGTN 1458

Query: 154  EPEEVATCVGRN--------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQ 205
             P EV+  + R+        G P P + W+K+G+PL              VE   L    
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPL--------FLGDPNVE---LLDRG 1507

Query: 206  SILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEG 265
             +L  +  + +   ++ C +     S    K+++++ + ++ P       V     +   
Sbjct: 1508 QVLHLKNARRNDKGRYQCTV-----SNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLIN 1562

Query: 266  DRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEP-ARKEHSGRYECQGLD 324
              +++ C   G P P  +  K       + +    D G  +  P A+   S  Y C   +
Sbjct: 1563 SLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVAN 1622

Query: 325  LDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE---- 380
            +             +   +     +P   +     SLTL C+A  +      WL++    
Sbjct: 1623 VAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPV 1682

Query: 381  ---ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKE 437
               +  ++   G  L++   +    G Y CVA+  S+ G    +   V +  PP +   +
Sbjct: 1683 KANDNIRIEAGGKKLEIMSAQEIDRGQYICVAT--SVAGEKEIKY-EVDVLVPPAIEGGD 1739

Query: 438  RKVW--VKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLN----VLVTPE 491
               +  V  N +L L C  +G P PTI W  +G   + ++D  ++L  LN    V+   +
Sbjct: 1740 ETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLID-ERDGFKIL--LNGRKLVIAQAQ 1796

Query: 492  LLETGV-ECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLS 533
            +  TG+  C A+N  G +      +   +T   P +  ++GLS
Sbjct: 1797 VSNTGLYRCMAANTAGDHK-----KEFEVTVHVPPTIKSSGLS 1834



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 75/328 (22%), Positives = 126/328 (38%), Gaps = 56/328 (17%)

Query: 165  NGYPIPQVIWYKNGRPLKEEKNRVHIQSSQT-------VESSGLYTLQSILKAQLVKEDK 217
            N  P P + WYK+G PL      + +   +        VE +G YT  ++ +A    ED 
Sbjct: 2802 NAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEA---GED- 2857

Query: 218  DAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGN 277
                   L Y +           V VP         L  E   ++ +   +E  CL+ G+
Sbjct: 2858 ------SLQYDV----------RVLVPPIIKGANSDLPEEVTVLVNKSALIE--CLSSGS 2899

Query: 278  PPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQ 336
            P P  S  K      E +      NG +L +   +    GRY C       +    +   
Sbjct: 2900 PAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVC-------VAENTAGSA 2952

Query: 337  ELLVNYVSDVRVSPAAPERQE-----GSSLTLTCEAESSQDLEFQWLREE-------TGQ 384
            +   N    V  S   P+ +       + ++LTCE       +  WL+ E          
Sbjct: 2953 KKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTL 3012

Query: 385  VLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERK----V 440
            ++  G  LQ+   K   GG Y C+A   +  G ++ +  ++ ++ PP +   + +    V
Sbjct: 3013 IVPGGRTLQIIRAKVSDGGEYTCIAI--NQAGESKKKF-SLTVYVPPSIKDHDSESLSVV 3069

Query: 441  WVKENMVLNLSCEASGHPRPTISWNVNG 468
             V+E   ++L CE++  P P I+W  NG
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNG 3097



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 99/445 (22%), Positives = 160/445 (35%), Gaps = 62/445 (13%)

Query: 101  LALTQVTPQDERIFLCQGKRPRSQEY-RIQLRVYKAPE-EPNIQVNPLGIPVNSKEPEEV 158
            L +++   +D   ++C  + P      +I+L V   P   P+++   + +       + +
Sbjct: 4043 LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVD------KPI 4096

Query: 159  ATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKD 218
                  +G P P + W+K+GR + E          Q V SSG   +  +       +  D
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVE-------SIRQRVLSSGSLQIAFV-------QPGD 4142

Query: 219  AQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNP 278
            A  Y  +   +   +       V VP   P  +     E    + E  +  + C+ADG P
Sbjct: 4143 AGHYTCMAANVAGSSSTSTKLTVHVP---PRIR---STEGHYTVNENSQAILPCVADGIP 4196

Query: 279  PPHFSISKQNPSTRE-AEEETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISLL 332
             P  +  K N        + T    G L+LE    E SG Y C      G D  T+    
Sbjct: 4197 TPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTV---- 4252

Query: 333  SEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREET-----GQVLE 387
                 L V+ +      P      +G  L L+C+A      +  W             + 
Sbjct: 4253 ----SLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVN 4308

Query: 388  RGPVLQLHDLKREAGGGYRCVA--SVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKE- 444
                L +  + +E  G Y C A  SV  +  +       V +  PP         W++  
Sbjct: 4309 GHSELVIERVSKEDSGTYVCTAENSVGFVKAIG-----FVYVKEPPVFKGDYPSNWIEPL 4363

Query: 445  --NMVLNLSCEASGHPRPTISWNVNGTASE-QDQDPQRVLSTLNVLVTPELLETGVECTA 501
              N +LN  CE  G P PTI WN  G   E   +  Q    +L +  T         C A
Sbjct: 4364 GGNAILN--CEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVA 4421

Query: 502  SNDLG--KNTSILFLELVNLTTLTP 524
            +N+ G  + +  L L+   + TL P
Sbjct: 4422 TNEAGVVERSMSLTLQSPPIITLEP 4446



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 74/320 (23%), Positives = 129/320 (40%), Gaps = 40/320 (12%)

Query: 168  PIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNY 227
            P   + WYK+G+PLK +    H+     + ++G +TLQ I +AQ+     D   Y  +  
Sbjct: 2702 PSASLSWYKDGQPLKSDD---HVN----IAANG-HTLQ-IKEAQI----SDTGRYTCVAS 2748

Query: 228  RLPSGNHMKESREVTVPVFYPTEKVW-----LEVEPVGMLKE---GDRVEIRCLADGNPP 279
             +   + +     + VP  +  +K+W     L+    G  K+    + + + C  +  PP
Sbjct: 2749 NIAGEDELDFDVNIQVPPSF--QKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPP 2806

Query: 280  PHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQEL 338
            P  +  K       +++      G VL +  A+ E +GRY C  ++     SL  + + L
Sbjct: 2807 PTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866

Query: 339  LVNYVSDVRVS-PAAPERQEGSSLTLTCEAESSQDLEFQW-------LREETGQVLERGP 390
            +   +       P         S  + C +  S      W       L ++  + L  G 
Sbjct: 2867 VPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGR 2926

Query: 391  VLQLHDLKREAGGGYRCVASVPSIPG---LNRTQLVNVAIFGPPWMAFKERKVWVKENMV 447
            +LQ+ + +    G Y CVA   +       N    V  ++ GP     K   + V  N  
Sbjct: 2927 ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGP-----KSENLTVVVNNF 2981

Query: 448  LNLSCEASGHPRPTISWNVN 467
            ++L+CE SG P P +SW  N
Sbjct: 2982 ISLTCEVSGFPPPDLSWLKN 3001



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 81/392 (20%), Positives = 146/392 (37%), Gaps = 48/392 (12%)

Query: 165  NGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCE 224
            +G P P VIW K G  +     +    +        LY +           ++  ++ C 
Sbjct: 1005 SGNPKPSVIWSKKGELISTSSAKFSAGAD-----GSLYVVSP-------GGEESGEYVCT 1052

Query: 225  LNYRLPSGNHMKESREVTV---PVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPP 280
                  +  + K   ++TV   P  +  ++   + +PV + +  G+ V + C     PPP
Sbjct: 1053 ATN---TAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPP 1109

Query: 281  HFSISKQNPSTRE-AEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELL 339
              + +K+       +   T   +G + +   R   SG Y C   ++   ++   +  +L 
Sbjct: 1110 IITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVT---QAVKLN 1166

Query: 340  VNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQW-------LREETGQVLERGPVL 392
            V+    ++  P   + Q G  + + C A+ +      W       L +    V      L
Sbjct: 1167 VHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTL 1226

Query: 393  QLHDLKREAGGGYRCVASVPSIPGLNRTQLV-------NVAIFGPPW-MAFKERKVWVKE 444
             +        G Y CVA+  +I G + T++         V    PP+   F+ER      
Sbjct: 1227 SIDQATPSDAGIYTCVAT--NIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVA---- 1280

Query: 445  NMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL--STLNVLVTPELLETG-VECTA 501
            N  +   C A G P+PTI W  NG      +    +L   TL V+ +    + G   C A
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVA 1340

Query: 502  SNDLGKNTSILFLELVNLTTLTPDSNTTTGLS 533
             N+ G  T   +   V++  +  D    T +S
Sbjct: 1341 VNEAG-TTERKYNLKVHVPPVIKDKEQVTNVS 1371



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 85/402 (21%), Positives = 155/402 (38%), Gaps = 55/402 (13%)

Query: 89   EQRLSLQDRGATLALTQVTPQDERIFLCQG-KRPRSQEYRIQLRVYKAPE-EPNIQVNPL 146
            E  +S+ + G  L +  VTP D   ++C       + E +  L+V+  P  +   QV  +
Sbjct: 1311 EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNV 1370

Query: 147  GIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQS 206
             + +N    +         G P P ++WYK+              + Q  ESS + T+ +
Sbjct: 1371 SVLLN----QLTNLFCEVEGTPSPIIMWYKD--------------NVQVTESSTIQTVNN 1412

Query: 207  --ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKE 264
              ILK      +   ++ C+    +   +    + +V VP   PT         V ++  
Sbjct: 1413 GKILKLFRATPEDAGRYSCKA-INIAGTSQKYFNIDVLVP---PTIIGTNFPNEVSVVLN 1468

Query: 265  GDRVEIRCLADGNPPP--HFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQG 322
             D V + C   G P P  H+    +     +   E  +   VL L+ AR+   GRY+C  
Sbjct: 1469 RD-VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTV 1527

Query: 323  LDL------DTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
             +       D  +++   P     N  +D+ V          S + L CE          
Sbjct: 1528 SNAAGKQAKDIKLTIYIPPSIKGGNVTTDISV-------LINSLIKLECETRGLPMPAIT 1580

Query: 377  WLRE-----ETGQVL--ERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFG 429
            W ++      + Q L  ++G  L +   +      Y C   V ++ G    +  +V ++ 
Sbjct: 1581 WYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTC--HVANVAG-TAEKSFHVDVYV 1637

Query: 430  PPWMAFKERKVWVKENMV---LNLSCEASGHPRPTISWNVNG 468
            PP +         K+ ++   L L C+A+G+P P ++W  +G
Sbjct: 1638 PPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDG 1679



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 90/426 (21%), Positives = 152/426 (35%), Gaps = 49/426 (11%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRS---QEYRIQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            G  L ++    +D   + C    P     +EY +++ V      PNI        +    
Sbjct: 3581 GEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHV-----PPNIAGTDEPRDITVLR 3635

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
              +V      +  P P + W +NG  L+    RV I S       G Y            
Sbjct: 3636 NRQVTLECKSDAVPPPVITWLRNGERLQATP-RVRILSG------GRYL----------- 3677

Query: 215  EDKDAQFYCELNYRLPSGNHM-KESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCL 273
            +  +A      NY   + N   K +RE  + V  P          V +L +   +E  C+
Sbjct: 3678 QINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLE--CI 3735

Query: 274  ADGNPPPHFSISKQNPSTREAEEE-TTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLL 332
            A+G P P  +  K            +  +NG L ++ A    +GRY C   +        
Sbjct: 3736 AEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNA---AGTD 3792

Query: 333  SEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLR----------EET 382
                +L V+    +   P           TL CEA         W +          + +
Sbjct: 3793 RRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNS 3852

Query: 383  GQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWV 442
             ++L  G ++ +     +    Y C  +V +  G ++ + V++ +  PP +A +     V
Sbjct: 3853 YRLLSSGSLVIISPSVDDTAT-YEC--TVTNGAGDDK-RTVDLTVQVPPSIADEPTDFLV 3908

Query: 443  KENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLST--LNVLVTPELLETGVECT 500
             ++    ++C ASG P P+I W  NG       D  R+LS+  + +L T         C 
Sbjct: 3909 TKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968

Query: 501  ASNDLG 506
            A N  G
Sbjct: 3969 ARNAAG 3974



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 35/144 (24%), Positives = 61/144 (42%), Gaps = 19/144 (13%)

Query: 332 LSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG-QVLERGP 390
           +SEP  + +   ++V V+P       G    LTC   S+ D    W R +   ++ E   
Sbjct: 516 VSEPPPV-IQVPNNVTVTP-------GERAVLTCLIISAVDYNLTWQRNDRDVRLAEPAR 567

Query: 391 V-------LQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
           +       L+L  +K    G Y C+ S     G +    V + +  PP +    +     
Sbjct: 568 IRTLANLSLELKSVKFNDAGEYHCMVSSE---GGSSAASVFLTVQEPPKVTVMPKNQSFT 624

Query: 444 ENMVLNLSCEASGHPRPTISWNVN 467
               +++ C A+G+P+P I+W VN
Sbjct: 625 GGSEVSIMCSATGYPKPKIAWTVN 648



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 79/388 (20%), Positives = 142/388 (36%), Gaps = 57/388 (14%)

Query: 95  QDRGATLALTQVTPQDERIFLC----QGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV 150
           +     L + +VT  DE  + C         R+Q +      +   E P +   P  + V
Sbjct: 478 ESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTF------FDVSEPPPVIQVPNNVTV 531

Query: 151 NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI-LK 209
              E   V TC+  +      + W +N R ++              E + + TL ++ L+
Sbjct: 532 TPGE-RAVLTCLIISAVDY-NLTWQRNDRDVR------------LAEPARIRTLANLSLE 577

Query: 210 AQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRV 268
            + VK +   +++C ++     G     S  +TV      E   + V P       G  V
Sbjct: 578 LKSVKFNDAGEYHCMVS---SEGGSSAASVFLTVQ-----EPPKVTVMPKNQSFTGGSEV 629

Query: 269 EIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTM 328
            I C A G P P  + +  +     +       +G L ++ A  + +G Y C   +    
Sbjct: 630 SIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASN---- 685

Query: 329 ISLLSEPQELLVNYVSDVRVSPAAPERQE--GSSLTLTCEAESSQDLEFQW------LRE 380
            S  ++ Q   + Y+   ++     E     G    + C+       + +W      LR 
Sbjct: 686 -SAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRP 744

Query: 381 ETGQVLERGPVLQLHDLKREA---GGGYRCVASVPSIPGLNR-TQLVNVAIFGPPWMAFK 436
            T  +++  P+L L  ++       G Y CVA    I    R T  + + +  PP    +
Sbjct: 745 STFLIID--PLLGLLKIQETQDLDAGDYTCVA----INEAGRATGKITLDVGSPPVFIQE 798

Query: 437 ERKVWVKENMVLNLSCEASGHPRPTISW 464
              V ++    + L C   G+P PTI W
Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKW 826


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 108/456 (23%), Positives = 168/456 (36%), Gaps = 60/456 (13%)

Query: 83   SEPGEYEQRL-SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVY-----KAP 136
            S P + EQR   L D  A L ++   P D   ++C  +       + Q+ V       AP
Sbjct: 3151 STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK-QVEVIVDTGAMAP 3209

Query: 137  EEPNIQVNPLGIPVNSKEPEEVATC-VGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQT 195
              P +Q     + V   E    AT      G P P + W K   PL  +    H     T
Sbjct: 3210 GAPQVQAEEAELTV---EAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ----HRLEGDT 3262

Query: 196  VESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLE 255
                        L    V +    Q+ C  N   P+G+      E T+ +   +      
Sbjct: 3263 ------------LIIPRVAQQDSGQYIC--NATSPAGH-----AEATIILHVESPPYATT 3303

Query: 256  VEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHS 315
            V     ++ G+ V+++CLA G PP  F  S+   S        T  N +L  E A  E S
Sbjct: 3304 VPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS---LPGRATARNELLHFERAAPEDS 3360

Query: 316  GRYECQ------GLDLDTMISLLSEPQELLVNYV-----SDVRVSPAAPERQEGSSLTLT 364
            GRY C+        +    + +   P  L    +       V+V+P    +  G+S+   
Sbjct: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420

Query: 365  CEAESSQDLEFQWLRE----ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT 420
            C   S +  + +W +E      G  ++ G VL++ +L +   G Y C A  P        
Sbjct: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDG-VLRIQNLDQSCQGTYICQAHGPWGKAQASA 3479

Query: 421  QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN-VNGTASEQDQDPQR 479
            QLV +       +  +     V     +   C A G P+P ++W+ V G           
Sbjct: 3480 QLV-IQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGG 3538

Query: 480  VLSTLNVLVTPELLETG-VECTASNDLGKNTSILFL 514
            V+   +V    EL + G   CTA+N  G   S + L
Sbjct: 3539 VVRIAHV----ELADAGQYRCTATNAAGTTQSHVLL 3570



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 94/448 (20%), Positives = 174/448 (38%), Gaps = 63/448 (14%)

Query: 95   QDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQV-NPLGIPVNSK 153
            Q RG+ L L  V+P D   ++C+            L   +A     + V  P G P    
Sbjct: 2772 QTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRI 2831

Query: 154  EPEEVATCVGRN--------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQ 205
            EP       G+         G    QV W+K G  L   +++VH                
Sbjct: 2832 EPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQVH---------------G 2875

Query: 206  SILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYP--------TEKVWLEVE 257
             +L+   V      ++ C++     S   ++ S  VT+    P         + +++E  
Sbjct: 2876 PLLRLNQVSPADSGEYSCQVT---GSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932

Query: 258  PVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGR 317
                + EG  +++ C+  G      +  K+  S     +   +   + ++ PA    SG 
Sbjct: 2933 S-SHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPA---DSGE 2988

Query: 318  YECQ-----GLDLDTMISLLSEPQELLVNYVSD--VRVSPAAPERQEGSSLTLTCEA-ES 369
            Y C+     G + +   ++   P E     +    + + P +   Q+G   +  C   + 
Sbjct: 2989 YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048

Query: 370  SQDLEFQWLR-----EETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVN 424
            +  +  +W       E+   +   G ++ +   +    G YRCVAS  +  G+ ++ +VN
Sbjct: 3049 AAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVAS--NAYGVAQS-VVN 3105

Query: 425  VAIFGPPWMA-FKERKVWVKENMVLNLSCEASGHPRPTISW-NVNGTASEQDQDPQRVLS 482
            +++ GPP ++   E  VWVK    + L C ++G PR +  W  ++ T ++ +Q    ++ 
Sbjct: 3106 LSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMD 3165

Query: 483  TLNVL----VTPELLETGVECTASNDLG 506
            +  VL      P    T V C A N LG
Sbjct: 3166 SHAVLQISSAKPSDAGTYV-CLAQNALG 3192



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 89/401 (22%), Positives = 138/401 (34%), Gaps = 56/401 (13%)

Query: 95   QDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNI-----QVNPLGIP 149
            Q  G  L L QV+P D   + CQ     S      + V   P  P          P+ I 
Sbjct: 2872 QVHGPLLRLNQVSPADSGEYSCQ-VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIE 2930

Query: 150  VNSKEPEEVAT----CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQ 205
             +S    E  T    CV   G    QV WYK G  L                     T  
Sbjct: 2931 ASSSHVTEGQTLDLNCVVP-GQAHAQVTWYKRGGSLPARHQ----------------THG 2973

Query: 206  SILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPV------FYPTEKVWLEVEPV 259
            S L+  LV      ++ C    R  SG   ++    TV V       Y      + ++P 
Sbjct: 2974 SQLRLHLVSPADSGEYVC----RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP 3029

Query: 260  GM-LKEGDRVEIRCLA-DGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGR 317
               +++G     +CL  DG  P       +N    +    + N + ++ +   R  + G 
Sbjct: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGS-IITIVGTRPSNHGT 3088

Query: 318  YECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQE-GSSLTLTCEAESSQDLEFQ 376
            Y C          +      L V+    V V P  P   + G ++TL C +        +
Sbjct: 3089 YRCVA---SNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSAR 3145

Query: 377  WLR---------EETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLV---N 424
            W R         + T  +++   VLQ+   K    G Y C+A         + +++    
Sbjct: 3146 WTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTG 3205

Query: 425  VAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN 465
                G P +  +E ++ V+      L C A+G P PTI W+
Sbjct: 3206 AMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWS 3246



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 97/476 (20%), Positives = 167/476 (35%), Gaps = 75/476 (15%)

Query: 21   VAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQ 80
            V G  G   Q +PE  +V  G T  L C  +      + + W              R+  
Sbjct: 1950 VHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPS--ATITW--------------RKEG 1993

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPE-- 137
            G   P    +R  +    ATL +  +T  D   +LC    P  + + RIQ+ V  A +  
Sbjct: 1994 GSLPPQARSERTDI----ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDAS 2049

Query: 138  EPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVE 197
             P +++      V   +  ++   V  + +   QV WY+ G  L     +VH        
Sbjct: 2050 PPPVKIESSSPSVTEGQTLDLNCVVAGSAH--AQVTWYRRGGSLPPH-TQVH-------- 2098

Query: 198  SSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFY---------- 247
                    S L+   V      ++ C    R+ +G+  KE+  +TV V +          
Sbjct: 2099 -------GSRLRLPQVSPADSGEYVC----RVENGSGPKEA-SITVSVLHGTHSGPSYTP 2146

Query: 248  -PTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVL 305
             P     + +EP    + EG  +++ C+  G      +  K+  S   A  +T     +L
Sbjct: 2147 VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARHQT--HGSLL 2203

Query: 306  VLEPARKEHSGRYECQGLDLDTMIS---LLSEPQELLVNYVSDVRVSPAAPERQEGSSLT 362
             L       SG Y C  +     +    L++    ++   +  VR+  ++    EG +L 
Sbjct: 2204 RLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLD 2263

Query: 363  LTCEAESSQDLEFQWLREE---TGQVLERGPVLQLHDLKREAGGGYRCVAS-------VP 412
            L+C        +  W +       +   RG  L +        G Y C AS         
Sbjct: 2264 LSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITV 2323

Query: 413  SIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
            ++ G     L   A    P +  +     V E   L+L+C   G     ++W+  G
Sbjct: 2324 TVTGTQGANLAYPAGSTQP-IRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG 2378



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 81/405 (20%), Positives = 147/405 (36%), Gaps = 57/405 (14%)

Query: 95   QDRGATLALTQVTPQDERIFLCQ---GKRPRSQEYRIQLR--VYKAPEEPNI--QVNPLG 147
            Q  G+ L L QV+P D   ++C+   G  P+     + +    +  P    +     P+ 
Sbjct: 2096 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIR 2155

Query: 148  IPVNSKEPEEVAT----CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYT 203
            I  +S    E  T    CV   G    QV W+K G  L                     T
Sbjct: 2156 IEPSSSHVAEGQTLDLNCVVP-GQAHAQVTWHKRGGSLPARHQ----------------T 2198

Query: 204  LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFY---PTEKVWLEVEPVG 260
              S+L+   V      ++ C +   + +   ++ S  VT+       P   V +E     
Sbjct: 2199 HGSLLRLHQVTPADSGEYVCHV---VGTSGPLEASVLVTIEASVIPGPIPPVRIESSS-S 2254

Query: 261  MLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
             + EG  +++ C+  G      +  K+  S     +   +   +    PA    +G+Y C
Sbjct: 2255 TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPA---DAGQYVC 2311

Query: 321  Q---GLDLDTMISLLSEPQELLV---NYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLE 374
            +   G++    +++       L         +R+ P++ +  EG +L L C        +
Sbjct: 2312 RASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQ 2371

Query: 375  FQWLREETGQVLER----GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNV----- 425
              W  +  G +  R    G +L+L+       G Y C     S+P L  + LV +     
Sbjct: 2372 VTW-HKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVP-LEASVLVTIEPAGS 2429

Query: 426  --AIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
              A+   P +  +     V E   L+L+C  +G     ++W+  G
Sbjct: 2430 VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 45/224 (20%), Positives = 87/224 (38%), Gaps = 16/224 (7%)

Query: 254  LEVEPV-GMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARK 312
            +EV P   ++ +G    +RC   G+PP +F  S+++     +  +  +    L     + 
Sbjct: 1679 VEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQP 1738

Query: 313  EHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQE-----GSSLTLTCEA 367
              +G Y C   +L       +   ELLV       ++    E++      G+ +T  C A
Sbjct: 1739 SDAGVYICTCRNLH---QSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTA 1795

Query: 368  ES-SQDLEFQWLREETGQV----LERGPVLQLHDLKREAGGGYRCVAS--VPSIPGLNRT 420
            +S S      W R   G++    ++   +L + +++    G Y C  S       G    
Sbjct: 1796 KSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATL 1855

Query: 421  QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
             +        P ++    ++ V+   +    C A+G P PT+ W
Sbjct: 1856 HVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 111/513 (21%), Positives = 194/513 (37%), Gaps = 78/513 (15%)

Query: 22   AGVPGEAEQPAPEL-VEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQ 80
            A  PG  +  A E  + VE G TA L+C  + S     H  W  +               
Sbjct: 3206 AMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIH--WSKLRS------------- 3250

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPEEP 139
                P  ++ RL     G TL + +V  QD   ++C    P    E  I L V   P   
Sbjct: 3251 ----PLPWQHRLE----GDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYAT 3302

Query: 140  NIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEE---KNRVHIQSSQTV 196
             +   P    V + E  ++  C+  +G P     W + G  L      +N +        
Sbjct: 3303 TV---PEHASVQAGETVQLQ-CLA-HGTPPLTFQWSRVGSSLPGRATARNELLHFERAAP 3357

Query: 197  ESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPV-FYPTEKVWLE 255
            E SG Y      + ++  +   A+ + +L  + P G+    S    +P    PT +V  +
Sbjct: 3358 EDSGRY------RCRVTNKVGSAEAFAQLLVQGPPGSLPATS----IPAGSTPTVQVTPQ 3407

Query: 256  VEPVGMLKEGDRVEIRCLAD---GNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARK 312
            +E   +   G  VE  C      G     F    Q P     ++      GVL ++   +
Sbjct: 3408 LETKSI---GASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD------GVLRIQNLDQ 3458

Query: 313  EHSGRYECQ-----GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEA 367
               G Y CQ     G    +   ++     +L+N  + V+          G ++   C A
Sbjct: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV------GHAVEFECLA 3512

Query: 368  ESSQDLEFQWLR---EETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVN 424
                  +  W +        +++ G V+++  ++    G YRC A+  +  G  ++ ++ 
Sbjct: 3513 LGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTAT--NAAGTTQSHVL- 3569

Query: 425  VAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN-VNGTASEQDQDPQRVLST 483
            + +   P ++  + +V V         C ASG+P P ISW+ ++G+     +    +L  
Sbjct: 3570 LLVQALPQISMPQ-EVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLML 3628

Query: 484  LNVLVTPELLETGVECTASNDLGKNTSILFLEL 516
             +  V P+   T V CTA+N  GK  +   L++
Sbjct: 3629 PS--VRPQDAGTYV-CTATNRQGKVKAFAHLQV 3658



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 91/427 (21%), Positives = 149/427 (34%), Gaps = 66/427 (15%)

Query: 79   GQGQSEPGEYEQRLSL----QDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLR--- 131
            GQ  ++   Y++  SL    Q RG+ L + Q +P D   ++C+          + +    
Sbjct: 2270 GQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQ 2329

Query: 132  ----VYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNR 187
                 Y A     I++ P    V   +  ++   V   G    QV W+K G  L      
Sbjct: 2330 GANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVP--GQSHAQVTWHKRGGSLPVRHQ- 2386

Query: 188  VHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVT----- 242
                           T  S+L+          ++ C +   L S   ++ S  VT     
Sbjct: 2387 ---------------THGSLLRLYQASPADSGEYVCRV---LGSSVPLEASVLVTIEPAG 2428

Query: 243  -VPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTND 301
             VP    T  V +E      + EG  +++ CL  G      +  K+  S     +   + 
Sbjct: 2429 SVPALGVTPTVRIESSS-SQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSR 2487

Query: 302  NGVLVLEPARKEHSGRYECQ--GLDLDTMISLLSEPQELLVNYVSD-----VRVSPAAPE 354
              +L + PA    SG Y C+  G       S+L   Q+ L    S      VR+  ++  
Sbjct: 2488 LRLLQVTPA---DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544

Query: 355  RQEGSSLTLTCEAESSQDLEFQWLREETGQVLER----GPVLQLHDLKREAGGGYRCVAS 410
               G +L L C   S       W +   G +  R    G  L++  +     G Y C   
Sbjct: 2545 LANGHTLDLNCLVASQAPHTITWYKRG-GSLPSRHQIVGSRLRIPQVTPADSGEYVC--H 2601

Query: 411  VPSIPGLNRTQLV---------NVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPT 461
            V +  G   T L+         +V    PP +  +     V E   L+L+C  +  P+  
Sbjct: 2602 VSNGAGSRETSLIVTIQGSGSSHVPSVSPP-IRIESSSPTVVEGQTLDLNCVVARQPQAI 2660

Query: 462  ISWNVNG 468
            I+W   G
Sbjct: 2661 ITWYKRG 2667



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 41/173 (23%), Positives = 65/173 (37%), Gaps = 7/173 (4%)

Query: 302  NGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPER--QEGS 359
            NG+L +   +   +G Y C G ++  M    +         +S   VS   P+   Q G 
Sbjct: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQ 1881

Query: 360  SLTLTCEAESSQDLEFQWLREETGQVLER----GPVLQLHDLKREAGGGYRCVASVPSIP 415
                 C A  S     +W     GQ+  +    G +L+L  ++      Y C A   +  
Sbjct: 1882 LAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQ 1941

Query: 416  GLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             + R  L +V   G P +     +  V     + L C A+G P  TI+W   G
Sbjct: 1942 QVARAVL-HVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 59/284 (20%), Positives = 92/284 (32%), Gaps = 33/284 (11%)

Query: 264  EGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQG- 322
            EG  +++ C+    P    +  K+  S     +        L L       SG Y C+  
Sbjct: 2643 EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ---THGSHLRLHQMSVADSGEYVCRAN 2699

Query: 323  -----LDLDTMISLL-SEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
                 L+   +IS+  S            +R+  ++    EG +L L C        +  
Sbjct: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT 2759

Query: 377  WLREE---TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNV-------- 425
            W +           RG  L+LH +     G Y C     S P L  + LV +        
Sbjct: 2760 WHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGP-LEASVLVTIEASGSSAV 2818

Query: 426  ---AIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLS 482
               A  G P +  +     V E   L+L C   G     ++W+  G            L 
Sbjct: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLL 2878

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDS 526
             LN +   +  E   + T S+          LE   L T+ P S
Sbjct: 2879 RLNQVSPADSGEYSCQVTGSSGT--------LEASVLVTIEPSS 2914



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 75/405 (18%), Positives = 130/405 (32%), Gaps = 67/405 (16%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPRSQEY---RIQLRVYKAPEEPNIQVNPLGIPVNS 152
            D    L +  V   D   ++C G    + +     + ++       P + ++P   P  +
Sbjct: 1820 DFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP---PQLT 1876

Query: 153  KEPEEVATC-VGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
             +P ++A       G P P + W          K ++H                 IL+  
Sbjct: 1877 VQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---------------GGILRLP 1921

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFY------PTEKVWLEVEPVGMLKEG 265
             V+    AQ+ C          H    ++V   V +      P  +V  E   V     G
Sbjct: 1922 AVEPTDQAQYLCRA--------HSSAGQQVARAVLHVHGGGGPRVQVSPERTQV---HAG 1970

Query: 266  DRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDL 325
              V + C A G P    +  K+  S          D   L++       +G Y C     
Sbjct: 1971 RTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVAT-- 2028

Query: 326  DTMISLLSEPQELLVNYVSD-----VRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE 380
             +         +++V   SD     V++  ++P   EG +L L C    S   +  W R 
Sbjct: 2029 -SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR 2087

Query: 381  ETG---QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF-----GPPW 432
                       G  L+L  +     G Y C     S P   +   + V++      GP +
Sbjct: 2088 GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGP---KEASITVSVLHGTHSGPSY 2144

Query: 433  ---------MAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
                     +  +     V E   L+L+C   G     ++W+  G
Sbjct: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRG 2189



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 45/170 (26%), Positives = 64/170 (37%), Gaps = 16/170 (9%)

Query: 346  VRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREE------TGQVLERGPVLQLHDLKR 399
            V V PA     +G S +L C+   S    F W RE+        Q   +G  L    ++ 
Sbjct: 1679 VEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQP 1738

Query: 400  EAGGGYRCVASVPSIPGLNRTQ-LVNVAIFGPPWMAFKE-RKVWVKENMVLNLSCEA-SG 456
               G Y C          +R + LV  A   P  +  +E R   V+    +   C A S 
Sbjct: 1739 SDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSK 1798

Query: 457  HPRPTISWN--VNGTASEQDQDPQRVLSTLNVLVTPELLETGV-ECTASN 503
             P  T+ W    NG    +  D   +L+  NV    +L + G   CT SN
Sbjct: 1799 SPAYTLVWTRLHNGKLPTRAMDFNGILTIRNV----QLSDAGTYVCTGSN 1844


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 100/427 (23%), Positives = 162/427 (37%), Gaps = 41/427 (9%)

Query: 113 IFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
           I LC G R R +++            P I  +P  + V+  EP  +  C    G P P +
Sbjct: 14  ICLCSGSRLRQEDF-----------PPRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTI 60

Query: 173 IWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSG 232
            WYK G  ++ +K+    +S + +  SG      I+  +  + D+        NY   + 
Sbjct: 61  EWYKGGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 118

Query: 233 NHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPST 291
           +H   S EV +         + +     M+  G+   + C    G+P P  S  K     
Sbjct: 119 SH-NASLEVAI-----LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL 172

Query: 292 REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPA 351
            + +E  T   G L++   RK  +G+Y C G ++  +    SE  EL V         P+
Sbjct: 173 DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM--VGERESEVAELTVLERPSFVKRPS 230

Query: 352 APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE---AG--GGYR 406
                   S    CEA        +W +++      R  +   H LK     AG  G Y 
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 407 CVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNV 466
           CVA   ++ G        + +  PP    K R   V     +   CEA+G+P+P I W  
Sbjct: 291 CVAE--NMVGKAEAS-ATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRR 347

Query: 467 NGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLELV 517
            G+ +      P +  S  +V  T +L  T V+        C   N  G   +  +LE+ 
Sbjct: 348 EGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT 407

Query: 518 NLTTLTP 524
           ++    P
Sbjct: 408 DVIADRP 414



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 110/479 (22%), Positives = 177/479 (36%), Gaps = 67/479 (13%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 160

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 161 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 202

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 203 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V       V
Sbjct: 261 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQEPPHFVV 316

Query: 349 SPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHDL-- 397
            P       G ++T  CEA  +      W RE +  +L          R  V Q  DL  
Sbjct: 317 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376

Query: 398 ---KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLN 449
              +R   G Y C       S+ +   L  T ++  A   PP +        V  +    
Sbjct: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDGTFV 434

Query: 450 LSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASNDLGK 507
           LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS   G+
Sbjct: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 494

Query: 508 NTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANSTST 548
            T   ++E+               NL    P     T +S +T +    P+  + +T T
Sbjct: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 553


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 102/428 (23%), Positives = 163/428 (38%), Gaps = 40/428 (9%)

Query: 113 IFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
           I LC G R R +++            P I  +P  + V+  EP  +  C    G P P +
Sbjct: 14  ICLCSGSRLRQEDF-----------PPRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTI 60

Query: 173 IWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSG 232
            WYK G  ++ +K+    +S + +  SG      I+  +  + D+        NY   + 
Sbjct: 61  EWYKGGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 118

Query: 233 NHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPST 291
           +H   S EV +         + +     M+  G+   + C    G+P P  S  K     
Sbjct: 119 SH-NASLEVAI-----LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL 172

Query: 292 REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPA 351
            + +E  T   G L++   RK  +G+Y C G ++  +    SE  EL V         P+
Sbjct: 173 DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM--VGERESEVAELTVLERPSFVKRPS 230

Query: 352 APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE---AG--GGYR 406
                   S    CEA        +W +++      R  +   H LK     AG  G Y 
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 407 CVA-SVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN 465
           CVA ++      + T  V V    PP    K R   V     +   CEA+G+P+P I W 
Sbjct: 291 CVAENMVGKAEASATLTVQVGS-EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349

Query: 466 VNGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLEL 516
             G+ +      P +  S  +V  T +L  T V+        C   N  G   +  +LE+
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409

Query: 517 VNLTTLTP 524
            ++    P
Sbjct: 410 TDVIADRP 417



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 111/482 (23%), Positives = 179/482 (37%), Gaps = 70/482 (14%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 160

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 161 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 202

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 203 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V   S+   
Sbjct: 261 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQVGSEPPH 316

Query: 349 SPAAPERQE---GSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHD 396
               P  Q    G ++T  CEA  +      W RE +  +L          R  V Q  D
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 397 L-----KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L     +R   G Y C       S+ +   L  T ++  A   PP +        V  + 
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDG 434

Query: 447 VLNLSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASND 504
              LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS  
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494

Query: 505 LGKNTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANST 546
            G+ T   ++E+               NL    P     T +S +T +    P+  + +T
Sbjct: 495 SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGAT 554

Query: 547 ST 548
            T
Sbjct: 555 PT 556


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 102/428 (23%), Positives = 163/428 (38%), Gaps = 40/428 (9%)

Query: 113 IFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
           I LC G R R +++            P I  +P  + V+  EP  +  C    G P P +
Sbjct: 14  ICLCSGSRLRQEDF-----------PPRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTI 60

Query: 173 IWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSG 232
            WYK G  ++ +K+    +S + +  SG      I+  +  + D+        NY   + 
Sbjct: 61  EWYKGGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 118

Query: 233 NHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPST 291
           +H   S EV +         + +     M+  G+   + C    G+P P  S  K     
Sbjct: 119 SH-NASLEVAI-----LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL 172

Query: 292 REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPA 351
            + +E  T   G L++   RK  +G+Y C G ++  +    SE  EL V         P+
Sbjct: 173 DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM--VGERESEVAELTVLERPSFVKRPS 230

Query: 352 APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE---AG--GGYR 406
                   S    CEA        +W +++      R  +   H LK     AG  G Y 
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 407 CVA-SVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN 465
           CVA ++      + T  V V    PP    K R   V     +   CEA+G+P+P I W 
Sbjct: 291 CVAENMVGKAEASATLTVQVGS-EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349

Query: 466 VNGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLEL 516
             G+ +      P +  S  +V  T +L  T V+        C   N  G   +  +LE+
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409

Query: 517 VNLTTLTP 524
            ++    P
Sbjct: 410 TDVIADRP 417



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 111/482 (23%), Positives = 179/482 (37%), Gaps = 70/482 (14%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 160

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 161 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 202

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 203 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V   S+   
Sbjct: 261 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQVGSEPPH 316

Query: 349 SPAAPERQE---GSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHD 396
               P  Q    G ++T  CEA  +      W RE +  +L          R  V Q  D
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 397 L-----KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L     +R   G Y C       S+ +   L  T ++  A   PP +        V  + 
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDG 434

Query: 447 VLNLSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASND 504
              LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS  
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494

Query: 505 LGKNTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANST 546
            G+ T   ++E+               NL    P     T +S +T +    P+  + +T
Sbjct: 495 SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGAT 554

Query: 547 ST 548
            T
Sbjct: 555 PT 556


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 102/428 (23%), Positives = 163/428 (38%), Gaps = 40/428 (9%)

Query: 113 IFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
           I LC G R R +++            P I  +P  + V+  EP  +  C    G P P +
Sbjct: 14  ICLCSGSRLRQEDF-----------PPRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTI 60

Query: 173 IWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSG 232
            WYK G  ++ +K+    +S + +  SG      I+  +  + D+        NY   + 
Sbjct: 61  EWYKGGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 118

Query: 233 NHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPST 291
           +H   S EV +         + +     M+  G+   + C    G+P P  S  K     
Sbjct: 119 SH-NASLEVAI-----LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL 172

Query: 292 REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPA 351
            + +E  T   G L++   RK  +G+Y C G ++  +    SE  EL V         P+
Sbjct: 173 DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM--VGERESEVAELTVLERPSFVKRPS 230

Query: 352 APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE---AG--GGYR 406
                   S    CEA        +W +++      R  +   H LK     AG  G Y 
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 407 CVA-SVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN 465
           CVA ++      + T  V V    PP    K R   V     +   CEA+G+P+P I W 
Sbjct: 291 CVAENMVGKAEASATLTVQVGS-EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349

Query: 466 VNGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLEL 516
             G+ +      P +  S  +V  T +L  T V+        C   N  G   +  +LE+
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409

Query: 517 VNLTTLTP 524
            ++    P
Sbjct: 410 TDVIADRP 417



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 111/482 (23%), Positives = 179/482 (37%), Gaps = 70/482 (14%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 160

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 161 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 202

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 203 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V   S+   
Sbjct: 261 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQVGSEPPH 316

Query: 349 SPAAPERQE---GSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHD 396
               P  Q    G ++T  CEA  +      W RE +  +L          R  V Q  D
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 397 L-----KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L     +R   G Y C       S+ +   L  T ++  A   PP +        V  + 
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDG 434

Query: 447 VLNLSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASND 504
              LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS  
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494

Query: 505 LGKNTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANST 546
            G+ T   ++E+               NL    P     T +S +T +    P+  + +T
Sbjct: 495 SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGAT 554

Query: 547 ST 548
            T
Sbjct: 555 PT 556


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 102/428 (23%), Positives = 163/428 (38%), Gaps = 40/428 (9%)

Query: 113 IFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQV 172
           I LC G R R +++            P I  +P  + V+  EP  +  C    G P P +
Sbjct: 14  ICLCSGSRLRQEDF-----------PPRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTI 60

Query: 173 IWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSG 232
            WYK G  ++ +K+    +S + +  SG      I+  +  + D+        NY   + 
Sbjct: 61  EWYKGGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 118

Query: 233 NHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPST 291
           +H   S EV +         + +     M+  G+   + C    G+P P  S  K     
Sbjct: 119 SH-NASLEVAI-----LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL 172

Query: 292 REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPA 351
            + +E  T   G L++   RK  +G+Y C G ++  +    SE  EL V         P+
Sbjct: 173 DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM--VGERESEVAELTVLERPSFVKRPS 230

Query: 352 APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKRE---AG--GGYR 406
                   S    CEA        +W +++      R  +   H LK     AG  G Y 
Sbjct: 231 NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYT 290

Query: 407 CVA-SVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWN 465
           CVA ++      + T  V V    PP    K R   V     +   CEA+G+P+P I W 
Sbjct: 291 CVAENMVGKAEASATLTVQVGS-EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349

Query: 466 VNGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLEL 516
             G+ +      P +  S  +V  T +L  T V+        C   N  G   +  +LE+
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409

Query: 517 VNLTTLTP 524
            ++    P
Sbjct: 410 TDVIADRP 417



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 111/482 (23%), Positives = 179/482 (37%), Gaps = 70/482 (14%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 160

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 161 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 202

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 203 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V   S+   
Sbjct: 261 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQVGSEPPH 316

Query: 349 SPAAPERQE---GSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHD 396
               P  Q    G ++T  CEA  +      W RE +  +L          R  V Q  D
Sbjct: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376

Query: 397 L-----KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L     +R   G Y C       S+ +   L  T ++  A   PP +        V  + 
Sbjct: 377 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDG 434

Query: 447 VLNLSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASND 504
              LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS  
Sbjct: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494

Query: 505 LGKNTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANST 546
            G+ T   ++E+               NL    P     T +S +T +    P+  + +T
Sbjct: 495 SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGAT 554

Query: 547 ST 548
            T
Sbjct: 555 PT 556


>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
          Length = 600

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 105/444 (23%), Positives = 170/444 (38%), Gaps = 69/444 (15%)

Query: 101 LALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT 160
           L + +   QD+ ++ CQ  +   +    +L V   P++P I   P+ I + + +P  + T
Sbjct: 112 LKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPLNL-T 169

Query: 161 CVGRNGYPIPQVIWYKNG---------RPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
           C   N  P   +IW + G         + L  +  R  I S+  +    +   QSI+   
Sbjct: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV--- 226

Query: 212 LVKEDKDAQFYCEL-NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                      C   N  +P G    +   VT+ + +P   V L VEP  +L E + V  
Sbjct: 227 -----------CRATNKAIPGG----KETSVTIDIQHPP-LVNLSVEPQPVL-EDNVVTF 269

Query: 271 RCLADGNPP-PHFSISKQNPSTREAEEET--TNDNGVLVLEPARKEHSGRYECQGLDLDT 327
            C A  NP    +  +K+    +EA  E   T  +     EP   E +       L    
Sbjct: 270 HCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329

Query: 328 MI----SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG 383
            +     + +EPQ LLV+                GS    +C    +  L   W++  +G
Sbjct: 330 DVYFGPRMTTEPQSLLVDL---------------GSDAIFSCAWTGNPSLTIVWMKRGSG 374

Query: 384 QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
            VL     L L  +++E  G Y C A VP +    R   V + + GPP ++  + +    
Sbjct: 375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGERE--VTLTVNGPPIISSTQTQ-HAL 431

Query: 444 ENMVLNLSCEASGHPRP---TISWNVN----GTAS----EQDQDPQRVLSTLNVL-VTPE 491
                 + C     P P     SW  N    GT+     E     + V+STL +  +   
Sbjct: 432 HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491

Query: 492 LLETGVECTASNDLGKNTSILFLE 515
             +T   CTA N  G +T I+ L+
Sbjct: 492 DFQTIYNCTAWNSFGSDTEIIRLK 515


>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
          Length = 778

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 105/444 (23%), Positives = 170/444 (38%), Gaps = 69/444 (15%)

Query: 101 LALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT 160
           L + +   QD+ ++ CQ  +   +    +L V   P++P I   P+ I + + +P  + T
Sbjct: 112 LKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPV-ISLRAGDPLNL-T 169

Query: 161 CVGRNGYPIPQVIWYKNG---------RPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
           C   N  P   +IW + G         + L  +  R  I S+  +    +   QSI+   
Sbjct: 170 CHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIV--- 226

Query: 212 LVKEDKDAQFYCEL-NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                      C   N  +P G    +   VT+ + +P   V L VEP  +L E + V  
Sbjct: 227 -----------CRATNKAIPGG----KETSVTIDIQHPP-LVNLSVEPQPVL-EDNVVTF 269

Query: 271 RCLADGNPP-PHFSISKQNPSTREAEEET--TNDNGVLVLEPARKEHSGRYECQGLDLDT 327
            C A  NP    +  +K+    +EA  E   T  +     EP   E +       L    
Sbjct: 270 HCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTV 329

Query: 328 MI----SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG 383
            +     + +EPQ LLV+                GS    +C    +  L   W++  +G
Sbjct: 330 DVYFGPRMTTEPQSLLVDL---------------GSDAIFSCAWTGNPSLTIVWMKRGSG 374

Query: 384 QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
            VL     L L  +++E  G Y C A VP +    R   V + + GPP ++  + +    
Sbjct: 375 VVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGERE--VTLTVNGPPIISSTQTQ-HAL 431

Query: 444 ENMVLNLSCEASGHPRP---TISWNVN----GTAS----EQDQDPQRVLSTLNVL-VTPE 491
                 + C     P P     SW  N    GT+     E     + V+STL +  +   
Sbjct: 432 HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRA 491

Query: 492 LLETGVECTASNDLGKNTSILFLE 515
             +T   CTA N  G +T I+ L+
Sbjct: 492 DFQTIYNCTAWNSFGSDTEIIRLK 515


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 104/443 (23%), Positives = 172/443 (38%), Gaps = 74/443 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIP-VNSKEPE 156
            G  L +   +P+D   +LC  K            V + P      V   G+P +++ E  
Sbjct: 2808 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP-----VIENGLPDLSTTEGS 2862

Query: 157  EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
                     G P P + W K+G+P+   + +       T++ SG   ++++       E 
Sbjct: 2863 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKF------TIQPSGELLVKNL-------EG 2909

Query: 217  KDAQFY-CELNYRLPSGNHMKESREVTVPVF--YPTEKVWLEVEPVGMLKEGDRVEIRCL 273
            +DA  Y C     +           + +PVF   P ++          L+ GDR+ +RC 
Sbjct: 2910 QDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---------SLRLGDRLWLRCA 2960

Query: 274  ADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPA-RKEHSGRYECQGLDLDTMISLL 332
            A G+P P    +  +    E   E   D G  +   A  +E SG Y C            
Sbjct: 2961 ARGSPTPRIGWTVNDRPVTEGVSE--QDGGSTLQRAAVSREDSGTYVCW----------- 3007

Query: 333  SEPQELLVNYVSDVRVSPAAPERQE---------GSSLTLTCEAESSQDLEFQWLRE--- 380
            +E +      VS V V  A   + E         G S+ L C        +  W+++   
Sbjct: 3008 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067

Query: 381  ----ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFK 436
                     L+ G  L +H  +R+  G Y+C+A   +  G+ + ++V + +   P    +
Sbjct: 3068 LRGSHLRHQLQNGS-LTIHRTERDDAGRYQCLAE--NEMGVAK-KVVILVLQSAPVFQVE 3123

Query: 437  ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTL-NVLVTPELLET 495
             + + V+    + L C+A+G P PTI W   G    Q     R L TL +  +  E +ET
Sbjct: 3124 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAG----QPLRASRRLRTLPDGSLWLENVET 3179

Query: 496  G----VECTASNDLGKNTSILFL 514
            G     +C A N LG  T+  FL
Sbjct: 3180 GDAGTYDCVAHNLLGSATARAFL 3202



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 109/480 (22%), Positives = 182/480 (37%), Gaps = 67/480 (13%)

Query: 24   VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQS 83
            VP   E P  E V    GS  +L C +S        V W                     
Sbjct: 1931 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT--VTWLK-----------------DR 1971

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQV 143
             P E      +  RG  L L+++ P     + C  +  +++  +    V      P I+ 
Sbjct: 1972 MPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDF--VVAVLVAPRIRS 2029

Query: 144  NPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYT 203
            + +    +  E +EV      +G P P V W K+G PL ++    H++      S  L  
Sbjct: 2030 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP-HLRFYLDGGSLVLKG 2088

Query: 204  LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYP-TEKVWLEVEPVGML 262
            L++           DA  Y  + +  P+G   +++R  TV V  P T K   +     + 
Sbjct: 2089 LRA----------SDAGAYTCVAHN-PAG---EDARLHTVNVLVPPTIKQGADGSGTLVS 2134

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYEC- 320
            + G+ V + C   G+PP H S  K       ++    + +G  L +   +   +G + C 
Sbjct: 2135 RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2194

Query: 321  ---------QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQ 371
                     +   L   +  + EP    V + +DV V         GS + L CEA    
Sbjct: 2195 AASPAGVADRNFTLQVQVPPVLEP----VEFQNDVVVV-------RGSLVELPCEARGVP 2243

Query: 372  DLEFQWLREET---GQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                 W+++      Q LE+GP LQL  +     G Y CVA   +       QL    + 
Sbjct: 2244 LPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT---VM 2300

Query: 429  GPPWM--AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNV 486
             PP +  + +  ++ +     + L C+A G P+P I+W+ +G A  + ++  R    L V
Sbjct: 2301 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV 2360



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 89/411 (21%), Positives = 151/411 (36%), Gaps = 61/411 (14%)

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNPLGIP 149
            RL + + G  L ++     D   ++C  +    S E    LRV   P    + +  +   
Sbjct: 1700 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 1759

Query: 150  VNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVE-------SSGLY 202
            +NS     V+     + +P P+V WYK+ + L   +    +  + T++        SG+Y
Sbjct: 1760 LNSS----VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1815

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
            T +++  A      +D Q   +L+  +P             P F    +     +   ++
Sbjct: 1816 TCEALNAA-----GRD-QKLVQLSVLVP-------------PAFRQAPR---GPQDAVLV 1853

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
            + GD+  + C  D  P P  +  K   P       +       L ++ A+    G Y C+
Sbjct: 1854 RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 1913

Query: 322  GLDLDTMISLLSEPQELLVNYVSDVRVSPA-------APERQEGSSLTLTCEAESSQDLE 374
                     + +   E +  +   V+V P           +  GS L LTC+        
Sbjct: 1914 ---------VSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT 1964

Query: 375  FQWLREE-------TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              WL++           V+ RG  LQL  L+    G Y CVA         R   V   +
Sbjct: 1965 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA--RKDFVVAVL 2022

Query: 428  FGPPWMAFK-ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDP 477
              P   +    R+  V E   + L CEA G P P ++W  +G+   QD  P
Sbjct: 2023 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP 2073



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 126/548 (22%), Positives = 193/548 (35%), Gaps = 81/548 (14%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V V V  TALL C        L  V W              R+ +   +P     R 
Sbjct: 2488 PPAVNVSVNQTALLPCQADGVPAPL--VSW--------------RKDRVPLDP--RSPRF 2529

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
             +   G +L +  V  QD   +LC        +   Q R  +  E P I  +P  + + +
Sbjct: 2530 EILPEG-SLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEPPAIAPSPSNLTLTA 2586

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTL--QSILKA 210
              P  +  C   +G P P V+W+K+G+ L     +            G Y L   + L  
Sbjct: 2587 HTP-ALLPCEA-SGSPKPLVVWWKDGQKLDFRLQQ------------GAYRLLPSNALLL 2632

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                    AQF C ++  +   + + +   V VP     ++    V  +        V +
Sbjct: 2633 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMA------PVVL 2685

Query: 271  RCLADGNPPPHFSISKQNPST-REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMI 329
             C + G P P  S SK              + +G L +  A   H+GRY C   +     
Sbjct: 2686 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN---SA 2742

Query: 330  SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE----ETG-- 383
             +  +   L V     V+  P+         + L CEA         W +E     TG  
Sbjct: 2743 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2802

Query: 384  -QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWV 442
             QVL  G  L++     E  G Y C+A   +   + +T+LV   +  PP +      +  
Sbjct: 2803 TQVLPGGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV---VQVPPVIENGLPDLST 2858

Query: 443  KENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVE---- 498
             E     L C+A G P P I+W+ +G      Q          +  + ELL   +E    
Sbjct: 2859 TEGSHAFLPCKARGSPEPNITWDKDG------QPVSGAEGKFTIQPSGELLVKNLEGQDA 2912

Query: 499  ----CTASNDLG---KNTSILFLELVNLTTLTPDSNTTTG-----LSTSTASPHTRANST 546
                CTA N +G   +   +  L L   TTL  D +   G        +  SP  R   T
Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2972

Query: 547  STERKLPE 554
              +R + E
Sbjct: 2973 VNDRPVTE 2980



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 69/249 (27%), Positives = 101/249 (40%), Gaps = 21/249 (8%)

Query: 236 KESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISK-QNPSTRE 293
           +  REV + V  P     +E  PV   + E   V + CLA G PPP  S  K   P +  
Sbjct: 682 ESKREVALKVLVPPN---IEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 738

Query: 294 AEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAP 353
                + D  VL +E A+   +G Y C   ++     L      L VN    + + P+ P
Sbjct: 739 MGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL---RYGLRVNVPPRITLPPSLP 795

Query: 354 -ERQEGSSLTLTCEAESSQDLEFQWLREETG---------QVLERGPVLQLHDLKREAGG 403
                 + + LTC A  +      WL++            QV   G VL L   +    G
Sbjct: 796 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSG 855

Query: 404 GYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTIS 463
            Y CVA   S  G +R  +V + +  PP +  +E  V V  N  + L C++   P P +S
Sbjct: 856 RYSCVA--VSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 912

Query: 464 WNVNGTASE 472
           W  +G   E
Sbjct: 913 WWKDGRPLE 921



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 113/479 (23%), Positives = 175/479 (36%), Gaps = 80/479 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNP-LGIPVNSKEP 155
            G  L + Q    D   + C       S E R  LRV   P  P I + P L  PV    P
Sbjct: 747  GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-NVP--PRITLPPSLPGPVLVNTP 803

Query: 156  EEVATCVGRNGYPIPQVIWYKNGRPLKEEKN---------RVHIQSSQTVESSGLYTLQS 206
              + TC    G P P ++W K+G P+              RV   +S     SG Y   S
Sbjct: 804  VRL-TC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY---S 858

Query: 207  ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
             +    V ED+                     ++V + V  P   +  E+    +  E  
Sbjct: 859  CVAVSAVGEDR---------------------QDVVLQVHMPPSILGEELNVSVVANES- 896

Query: 267  RVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDL 325
             V + C +   PPP  S  K   P         + D  +L ++ A    +G Y C+ L+ 
Sbjct: 897  -VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN- 954

Query: 326  DTMISLLSEPQELLVNYVSDVRVSPAAPERQ-------EGSSLTLTCEAESSQDLEFQWL 378
                    +      +Y  +V V+P  P R+       EG   +L+CE       +  W 
Sbjct: 955  --------QAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 1006

Query: 379  REETGQVLER-----------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
            ++  GQ L             G +L L   +    G Y C  S  ++ G N +Q + + +
Sbjct: 1007 KD--GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS--NVVG-NSSQDLQLEV 1061

Query: 428  FGPPWMAFKER---KVWVKENMVLNLSCEASGHPRPTISWNVNG--TASEQDQDPQRVLS 482
              PP +A       +V V ++ V  L C A+G P PT++W  +G    +E     Q    
Sbjct: 1062 HVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1121

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHT 541
            +L+V            C A N  G+      L ++    L  D +  T ++ +  SP T
Sbjct: 1122 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1180



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 89/426 (20%), Positives = 159/426 (37%), Gaps = 48/426 (11%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            ++G +L L  V   D   + C       +  R  QL V + P   +    P  + +    
Sbjct: 2262 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED-SGQPTELSLTPGA 2320

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
            P E+       G P P + W+K+G+ L   +N         V  +GLYT  +   A  ++
Sbjct: 2321 PMELLC--DAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIE 2378

Query: 215  EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
            +    +     N   P G           P F            VG+     ++ + C  
Sbjct: 2379 KSFRVRVQAPPNIVGPRG-----------PRFV-----------VGLAP--GQLVLECSV 2414

Query: 275  DGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLS 333
            +  P P  +  +     +E       + G  L L+      SG Y C   +     S+  
Sbjct: 2415 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2474

Query: 334  EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG--------QV 385
              +   ++ V  +R  P A       +  L C+A+        W ++           ++
Sbjct: 2475 RVE---IHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2531

Query: 386  LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKEN 445
            L  G  L++  +  +  G Y C+AS  +  G +R Q  ++ +  PP +A     + +  +
Sbjct: 2532 LPEGS-LRIQPVLAQDAGHYLCLAS--NSAGSDR-QGRDLRVLEPPAIAPSPSNLTLTAH 2587

Query: 446  MVLNLSCEASGHPRPTISWNVNGTASE--QDQDPQRVLSTLNVLVTPELLETGV--ECTA 501
                L CEASG P+P + W  +G   +    Q   R+L +  +L+T    +     EC  
Sbjct: 2588 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 2647

Query: 502  SNDLGK 507
            SN++G+
Sbjct: 2648 SNEVGE 2653



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 108/443 (24%), Positives = 167/443 (37%), Gaps = 67/443 (15%)

Query: 101  LALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVA 159
            L + +V  +DE I+ C       +  R + L+V   P   NI+  P+   V   E   V 
Sbjct: 659  LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAV--LENASVT 713

Query: 160  TCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDA 219
                 +G P P V W+K  +P       V      TV   G   +  I +AQL     DA
Sbjct: 714  LECLASGVPPPDVSWFKGHQP-------VSSWMGVTVSVDG--RVLRIEQAQL----SDA 760

Query: 220  QFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPP 279
              Y  +   +     ++    V VP      ++ L     G +     V + C A G P 
Sbjct: 761  GSYRCVASNVAGSTELRYGLRVNVP-----PRITLPPSLPGPVLVNTPVRLTCNATGAPS 815

Query: 280  PHFSISKQNPSTREAEE---ETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISL 331
            P     K       A     +      VL L  AR   SGRY C      G D   ++  
Sbjct: 816  PTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ 875

Query: 332  LSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGP- 390
            +  P  +L     ++ VS  A E     S+ L C++ +       W ++  G+ LE  P 
Sbjct: 876  VHMPPSIL---GEELNVSVVANE-----SVALECQSHAMPPPVLSWWKD--GRPLEPRPG 925

Query: 391  --------VLQLHDLKREAGGGYRCVASVPSIPGLNRT----QLVNVAIFGPPWMAFKE- 437
                    +LQ+        G Y C A       LN+     +  N+ ++  P    +E 
Sbjct: 926  VHLSADKALLQVDRADVWDAGHYTCEA-------LNQAGRSEKHYNLNVWVAPVFPLRES 978

Query: 438  RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLV---TPELLE 494
              + V+E    +LSCE  G P P ISW  +G     +    + +S +  L+     +L +
Sbjct: 979  HTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ 1038

Query: 495  TGV-ECTASNDLGKNTSILFLEL 516
             G   C  SN +G ++  L LE+
Sbjct: 1039 EGTYTCECSNVVGNSSQDLQLEV 1061



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 84/334 (25%), Positives = 130/334 (38%), Gaps = 50/334 (14%)

Query: 167  YPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELN 226
            +P P + W K+G P +  +N   +         G + LQ IL AQ  KED   Q+ C + 
Sbjct: 1377 FPSPNITWMKDGAPFEASRNIQLLP--------GTHGLQ-ILNAQ--KEDA-GQYTCVVT 1424

Query: 227  YRLPSGNHMKESR-EVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSI 284
              L  G  +K    EV +P     +    EV    +  K    + + C +   PPP    
Sbjct: 1425 NEL--GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW 1482

Query: 285  SKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISLLSEPQEL 338
             K   P T  +  +   +  +L ++P +   SGRY C      G D      L+  P   
Sbjct: 1483 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP-- 1540

Query: 339  LVNYVSDVRVSPAAPERQE--------------GSSLTLTCEAESSQDLEFQWLREETG- 383
            +   V D   +     R+E               +   L C+  +    +  W RE+   
Sbjct: 1541 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL 1600

Query: 384  ------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKE 437
                   VL+ G VLQ+  ++ E  G Y C AS  +  G +      + +  P  +   E
Sbjct: 1601 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NEVGEDWLHYELLVLTPPVILGDTE 1658

Query: 438  R---KVWVKENMVLNLSCEASGHPRPTISWNVNG 468
                +V V  +  ++L C A G+P PTISW  NG
Sbjct: 1659 ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG 1692



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 108/493 (21%), Positives = 168/493 (34%), Gaps = 53/493 (10%)

Query: 31   PAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQ 90
            P+P  + +   + ALL C  S S   L  V W+   K+ + L FR++QG  +  P     
Sbjct: 2577 PSPSNLTLTAHTPALLPCEASGSPKPL--VVWW---KDGQKLDFRLQQGAYRLLPSN--- 2628

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV 150
                      L LT   PQD   F C       + +R+       P  P I  +     V
Sbjct: 2629 ---------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTV 2677

Query: 151  NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKA 210
                P  V TC    G P P V W K G  L    +   +  S  +E      + +    
Sbjct: 2678 TMMAPV-VLTCHS-TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA---- 2731

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                     ++ C         +          PV  P   V   V         + V +
Sbjct: 2732 --------GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE-------EEVLL 2776

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMIS 330
             C A G P P  +  K+  +            G L +  A  E +G Y C  +  ++  S
Sbjct: 2777 PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC--IAKNSAGS 2834

Query: 331  LLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETG 383
             + + + L+V     +          EGS   L C+A  S +    W ++       E  
Sbjct: 2835 AMGKTR-LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 2893

Query: 384  QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
              ++    L + +L+ +  G Y C A   +  G  R + V++ I   P          ++
Sbjct: 2894 FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRARRR-VHLTILVLPVFTTLPGDRSLR 2950

Query: 444  ENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASN 503
                L L C A G P P I W VN     +    Q   STL              C A N
Sbjct: 2951 LGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 3010

Query: 504  DLGKNTSILFLEL 516
             +G+  ++ F+ +
Sbjct: 3011 RVGRTQAVSFVHV 3023



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 101/508 (19%), Positives = 179/508 (35%), Gaps = 89/508 (17%)

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRP---RSQEYRIQLRV---YK 134
            GQ  PGE      +   G  L L Q     E  + C+        SQ+ ++++ V     
Sbjct: 1009 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 1068

Query: 135  APEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP--------LKEEKN 186
             P EP  QV+ +   V + E           G P P V W ++G+P        L+ +  
Sbjct: 1069 GPREPPTQVSVVQDGVATLE-------CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1121

Query: 187  RVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVF 246
             +H++ +Q   +     +   L                           +  R+  + V 
Sbjct: 1122 SLHVERAQAAHTGRYSCVAENLAG-------------------------RAERKFELSVL 1156

Query: 247  YPTEKVWLEVEPVGMLKEG--DRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG- 303
             P E +  +++P+  +       + + C A G PPP     +        E+      G 
Sbjct: 1157 VPPELIG-DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW 1215

Query: 304  VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ------- 356
            +L +   +++ SG Y C   +         E  E   N+  +V V P+            
Sbjct: 1216 MLKMTQTQEQDSGLYSCLASN---------EAGEARRNFSVEVLVPPSIENEDLEEVIKV 1266

Query: 357  -EGSSLTLTCEAESSQDLEFQWLREETGQVLERGP---------VLQLHDLKREAGGGYR 406
             +G +  L C        +  W ++  G+ L RG          +LQ+      + G Y 
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1324

Query: 407  CVASVPSIPGLNRTQLVNVAIFGPPWMAFKE----RKVWVKENMVLNLSCEASGHPRPTI 462
            C+A+  +  G          +  P  +   E     +V V  N  ++L CEA   P P I
Sbjct: 1325 CIAA--NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 1382

Query: 463  SWNVNGTASEQDQDPQRVLST--LNVLVTPELLETGVECTASNDLGKNTSILFLELVNLT 520
            +W  +G   E  ++ Q +  T  L +L   +       C  +N+LG+      +E++   
Sbjct: 1383 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1442

Query: 521  TLTPDSNTTTGLSTSTASPHTRANSTST 548
            +++ D               T+ NST T
Sbjct: 1443 SISKDDPLG---EVGVKEVKTKVNSTLT 1467



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 118/501 (23%), Positives = 187/501 (37%), Gaps = 106/501 (21%)

Query: 78   QGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPE 137
            +G+    PGE    L+    G  L +TQ   QD  ++ C       +  R        P 
Sbjct: 1197 RGEEPVSPGEDTYLLA---GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP- 1252

Query: 138  EPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKE------EKNRVHIQ 191
             P+I+   L   +   + +         G+P P++ W+K+GRPL          + V +Q
Sbjct: 1253 -PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQ 1311

Query: 192  SSQT-VESSGLYTLQSILKAQLVKED-KDAQFYCELNYRLPSGNHMKESREVTVPVFYPT 249
              Q  + S+G Y   S + A  V E  K  Q    L   +  G       EVTV V  P 
Sbjct: 1312 VLQANLSSAGHY---SCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP- 1367

Query: 250  EKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAE--EETTNDNGVLVL 307
                              + + C A   P P+ +  K       +   +     +G+ +L
Sbjct: 1368 ------------------ISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQIL 1409

Query: 308  EPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPE------------- 354
              A+KE +G+Y C          + +E  E + NY  +V + P+  +             
Sbjct: 1410 N-AQKEDAGQYTCV---------VTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 1459

Query: 355  RQEGSSLTLTCEAESSQDLEFQWLREETG-------QVLERGPVLQLHDLKREAGGGYRC 407
             +  S+LTL CE+ +      +W ++          QVL  G +LQ+   +    G Y C
Sbjct: 1460 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1519

Query: 408  VASVPSIPGLNRTQLVNVAIFGPPWM--------AF----KERKV--------WVKENMV 447
            VA+  ++ G    Q  NV I  PP          AF    +E +          + EN  
Sbjct: 1520 VAT--NVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 1576

Query: 448  LNLSCEASGHPRPTISWNVNGTASEQDQ-----DPQRVLSTLNVLVTPELLETGV---EC 499
              L C+ +  P P ++W        +DQ     D   VL    VL  P +         C
Sbjct: 1577 AYLYCDTNAIPPPDLTW------YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1630

Query: 500  TASNDLGKNTSILFLELVNLT 520
             ASN++G++   L  EL+ LT
Sbjct: 1631 KASNEVGEDW--LHYELLVLT 1649



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 56/230 (24%), Positives = 88/230 (38%), Gaps = 25/230 (10%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVN 151
            +S QD G+TL    V+ +D   ++C  +    +   +     K  E P +Q       V 
Sbjct: 2982 VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK--EAPVLQGEAFSYLVE 3039

Query: 152  SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
                     CV R G P+P + W K+G PL+    R  +Q+               L   
Sbjct: 3040 PVGGSIQLDCVVR-GDPVPDIHWIKDGLPLRGSHLRHQLQNGS-------------LTIH 3085

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEI 270
              + D   ++ C         N M  +++V + V         +VEP  M ++ GD V +
Sbjct: 3086 RTERDDAGRYQCLAE------NEMGVAKKVVILVLQSAPV--FQVEPQDMTVRSGDDVAL 3137

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
            RC A G P P     +     R +    T  +G L LE      +G Y+C
Sbjct: 3138 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDC 3187



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 108/449 (24%), Positives = 170/449 (37%), Gaps = 69/449 (15%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
            G +L L  +   D   + C    P  ++ R+       P  P I+    G       P E
Sbjct: 2081 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVP--PTIKQGADGSGTLVSRPGE 2138

Query: 158  VAT--CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKE 215
            + T  C  R   PI  V W K+G PL          S +T+     +TL+ I K QL   
Sbjct: 2139 LVTMVCPVRGSPPI-HVSWLKDGLPLP--------LSQRTLLHGSGHTLR-ISKVQLADA 2188

Query: 216  DKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD 275
                 F C      P+G      R  T+ V  P     +E +   ++  G  VE+ C A 
Sbjct: 2189 ---GIFTCVA--ASPAG---VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEAR 2240

Query: 276  GNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LDTM 328
            G P P  S  K   P   ++ E+  +    L LE      SG Y C  +           
Sbjct: 2241 GVPLPLVSWMKDGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2296

Query: 329  ISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLER 388
            ++++  P        +++ ++P AP       + L C+A+ +      W ++  GQ L R
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAP-------MELLCDAQGTPQPNITWHKD--GQALTR 2347

Query: 389  -------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVA----IFGPPWMAFKE 437
                     VL++ D      G Y C+A  P+   + ++  V V     I GP    F  
Sbjct: 2348 LENNSRATRVLRVRD-----AGLYTCLAESPA-GAIEKSFRVRVQAPPNIVGPRGPRFV- 2400

Query: 438  RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQD---QDPQR-VLSTLNVLVTPELL 493
              V +    ++ L C     P P I+W+ +G   ++D   Q P+R     L  L T +  
Sbjct: 2401 --VGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD-- 2455

Query: 494  ETGVECTASNDLGKNTSILFLELVNLTTL 522
                 CTA N  G  +    +E+  + T+
Sbjct: 2456 SGDYSCTARNAAGSTSVAFRVEIHTVPTI 2484



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 90/394 (22%), Positives = 146/394 (37%), Gaps = 56/394 (14%)

Query: 98  GATLALTQVTPQDERIFLCQGKRP-RSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPE 156
           G  L L +    D  ++ C+      + E   +L VY  P        P  +   +  P 
Sbjct: 364 GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPV 423

Query: 157 EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
            +  CV R G+P P + W+  G P+ E               S L T  S+L+ +   E 
Sbjct: 424 ALE-CVAR-GHPSPTLSWHHEGLPVAESNE------------SRLETDGSVLRLESPGEA 469

Query: 217 KDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLEVEPVGMLKE--GDRVEIRCL 273
               + C  +   P+G  + + S EV VP         L  E +G +    G  +E+ C 
Sbjct: 470 SSGLYSCVASS--PAGEAVLQYSVEVQVP------PQLLVAEGLGQVTTIVGQPLELPCQ 521

Query: 274 ADGNPPPHFS-ISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LD 326
           A G+P P    +    P+   A  +  +    L ++    +HSG + CQ  +       +
Sbjct: 522 ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 581

Query: 327 TMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCE--------AESSQDLEFQWL 378
             +S+  E        V +V +       +  SS    C+        A     L   W 
Sbjct: 582 VEVSVHGE----WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 637

Query: 379 R------EETGQVLERG--PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
                  E TG  +     P LQ+  +     G Y C A+  ++ G ++ + V + +  P
Sbjct: 638 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKRE-VALKVLVP 694

Query: 431 PWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
           P +        V EN  + L C ASG P P +SW
Sbjct: 695 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW 728



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 79/356 (22%), Positives = 135/356 (37%), Gaps = 35/356 (9%)

Query: 165 NGYPIPQVIWYKNGRPLKEEKNRVHIQSS-QTVESSGLYTLQSILKAQLVKEDKDAQFYC 223
           +G P PQV W K+ +P+      + +Q   Q +  +G +               + ++ C
Sbjct: 242 SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV------------GDEGRYQC 289

Query: 224 ELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHF 282
                 P+G   +++R+  + V  P   +W   E   + + E   V++ C A G P P+ 
Sbjct: 290 VAFS--PAG---QQARDFQLRVHAPPT-IWGSNETGEVAVMEDHLVQLLCEARGVPTPNI 343

Query: 283 SISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVN 341
           +  K       + +      G  L L  A+   +G Y C+  +        +     +  
Sbjct: 344 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 403

Query: 342 YVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETGQVLERGPVLQL 394
            +      P   +   G  + L C A         W  E          ++   G VL+L
Sbjct: 404 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRL 463

Query: 395 HDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKER--KVWVKENMVLNLSC 452
                 + G Y CVAS P+   + +    +V +  PP +   E   +V       L L C
Sbjct: 464 ESPGEASSGLYSCVASSPAGEAVLQ---YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPC 520

Query: 453 EASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVT-PELLETGV-ECTASNDLG 506
           +ASG P PTI W  NG  +E+    Q       + +   EL  +G+  C A+N+ G
Sbjct: 521 QASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 69/312 (22%), Positives = 115/312 (36%), Gaps = 37/312 (11%)

Query: 166  GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCEL 225
            G P+P + W +NG P         ++  Q            +L+    +    A + C  
Sbjct: 1680 GNPVPTISWLQNGLPFSPSPRLQVLEDGQ------------VLQVSTAEVADAASYMCVA 1727

Query: 226  NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSIS 285
              +  S   +      T+ V  P     L++E V  +     V + C    +P P  +  
Sbjct: 1728 ENQAGSAEKL-----FTLRVQVPPRIAGLDLEQVTAILNSS-VSLPCDVHAHPNPEVTWY 1781

Query: 286  KQNPSTREAEEE-TTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS 344
            K + +    EE         L L  AR   SG Y C+ L+       L    +L V    
Sbjct: 1782 KDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPP 1838

Query: 345  DVRVSPAAPER----QEGSSLTLTCEAESSQDLEFQWLRE-------ETGQVLERGPVLQ 393
              R +P  P+     + G    L+CE ++  +    W ++       +  Q L  G  L+
Sbjct: 1839 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 1898

Query: 394  LHDLKREAGGGYRCVASVPSIPG-LNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSC 452
            + + +    G Y C   V ++ G   RT  + V +  P +   K   V       L L+C
Sbjct: 1899 IQEAQVSDKGLYSC--KVSNVAGEAVRTFTLTVQV-PPTFENPKTETVSQVAGSPLVLTC 1955

Query: 453  EASGHPRPTISW 464
            + SG P PT++W
Sbjct: 1956 DVSGVPAPTVTW 1967



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 94/447 (21%), Positives = 164/447 (36%), Gaps = 59/447 (13%)

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPEEPNIQ 142
            +P   E  L LQ++G +L + +        + C  +    + E + +L V   PE     
Sbjct: 1106 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIG-D 1164

Query: 143  VNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLY 202
            ++PL     +        C    G P P + W++   P+               E + L 
Sbjct: 1165 LDPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGEEPVSPG------------EDTYLL 1211

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
                +LK    +E     + C     L S    +  R  +V V  P      ++E V  +
Sbjct: 1212 AGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 1266

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLV-LEPARKEHSGRYECQ 321
             +G    + C   G+P P  +  K        +    + +GVL+ +  A    +G Y C 
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326

Query: 322  GLDL------DTMISLLSEPQELL-VNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLE 374
              +          +S+L  P  L      +D  V+         + ++L CEA +     
Sbjct: 1327 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV-----NNPISLICEALAFPSPN 1381

Query: 375  FQWLREETG-------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              W+++          Q+L     LQ+ + ++E  G Y CV +      +      +V +
Sbjct: 1382 ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN---YHVEV 1438

Query: 428  FGPPWMAFKE-------RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV 480
              PP ++  +       ++V  K N  L L CE+   P PTI W        +D  P   
Sbjct: 1439 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-------YKDGQPVTP 1491

Query: 481  LSTLNVLVTPELLETGVECTASNDLGK 507
             S L VL    LL+  ++ T  +D G+
Sbjct: 1492 SSRLQVLGEGRLLQ--IQPTQVSDSGR 1516



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 104/465 (22%), Positives = 168/465 (36%), Gaps = 62/465 (13%)

Query: 83  SEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRP-RSQEYRIQLRVYKAPE--EP 139
           SEP   +  +++ + G+ L L  V+P D   + CQ      S   R +L VY  P   E 
Sbjct: 42  SEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRED 100

Query: 140 NIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKN----GRPLKEEKNRVHIQSSQT 195
             + N  G+   S   E  A     NG+P+P+++W K+    G PL        +   Q 
Sbjct: 101 GRKANVSGMAGQSLTLECDA-----NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 155

Query: 196 VESSGLYTLQSILKAQLV---KEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKV 252
                L   QS+   ++       + AQ       + P    +    +      +PT   
Sbjct: 156 GGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQ------FPTPHA 209

Query: 253 WLEVEPVGMLKEGDRVEI----------RCLADGNPPPHFSISKQNPSTREA--EEETTN 300
           +    P  +L  G   E+          +C   G P P    +K            +   
Sbjct: 210 FSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQE 269

Query: 301 DNGVLVLEPARKEHSGRYECQGLD------LDTMISLLSEPQELLVNYVSDVRVSPAAPE 354
           D  VL +  +     GRY+C           D  + + + P     N   +V V      
Sbjct: 270 DGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAV------ 323

Query: 355 RQEGSSLTLTCEAESSQDLEFQWLRE------ETGQVLER-GPVLQLHDLKREAGGGYRC 407
             E   + L CEA         W ++       T  V  R G  LQL   +    G Y C
Sbjct: 324 -MEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTC 382

Query: 408 VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMV---LNLSCEASGHPRPTISW 464
            AS         T+L    ++ PP +     + +V + +    + L C A GHP PT+SW
Sbjct: 383 KASNAVGAAEKATRL---DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 439

Query: 465 NVNG-TASEQDQDPQRVLSTLNVLVTPELLETGV-ECTASNDLGK 507
           +  G   +E ++       ++  L +P    +G+  C AS+  G+
Sbjct: 440 HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE 484



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 86/400 (21%), Positives = 133/400 (33%), Gaps = 73/400 (18%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPR---SQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
            +RG  L L  ++  D   + C  +      S  +R+++        P I+  P  + V+ 
Sbjct: 2441 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-----PTIRSGPPAVNVSV 2495

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL 212
             +   +  C   +G P P V W K+  PL     R  I              +  L+ Q 
Sbjct: 2496 NQTA-LLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILP------------EGSLRIQP 2541

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPT-EKVWLEVEPVGMLKEGDRVEIR 271
            V       + C  +    S    ++ R +  P   P+   + L      +L         
Sbjct: 2542 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP-------- 2593

Query: 272  CLADGNPPPHFSISKQNPST----REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDT 327
            C A G+P P     K         ++        N +L+  P  ++ S ++EC       
Sbjct: 2594 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD-SAQFEC------V 2646

Query: 328  MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLT------LTCEAESSQDLEFQW---- 377
            + + + E   L   Y   V V P   + Q   ++T      LTC +         W    
Sbjct: 2647 VSNEVGEAHRL---YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG 2703

Query: 378  ---------LREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                      R      LE G  L +H       G Y C  S  +  G+    +      
Sbjct: 2704 AQLGARGSGYRVSPSGALEIGQALPIH------AGRYTC--SARNSAGVAHKHVFLTVQA 2755

Query: 429  GPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             P           V E  VL L CEASG PRPTI+W   G
Sbjct: 2756 SPVVKPLPSVVRAVAEEEVL-LPCEASGIPRPTITWQKEG 2794



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 9/114 (7%)

Query: 272 CLADGNPPPHFSISKQNPSTREAEEE---TTNDNGVLVLEPARKEHSGRYECQGLDLDTM 328
           C   G P P  +  K  PS+     +      + G L L       SG YECQ  +    
Sbjct: 24  CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATN---E 79

Query: 329 ISLLSEPQELLVNYVSDVRVS--PAAPERQEGSSLTLTCEAESSQDLEFQWLRE 380
           +   S   +L+V     +R     A      G SLTL C+A      E  WL++
Sbjct: 80  VGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKD 133


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 104/443 (23%), Positives = 172/443 (38%), Gaps = 74/443 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIP-VNSKEPE 156
            G  L +   +P+D   +LC  K            V + P      V   G+P +++ E  
Sbjct: 3999 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP-----VIENGLPDLSTTEGS 4053

Query: 157  EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
                     G P P + W K+G+P+   + +       T++ SG   ++++       E 
Sbjct: 4054 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKF------TIQPSGELLVKNL-------EG 4100

Query: 217  KDAQFY-CELNYRLPSGNHMKESREVTVPVF--YPTEKVWLEVEPVGMLKEGDRVEIRCL 273
            +DA  Y C     +           + +PVF   P ++          L+ GDR+ +RC 
Sbjct: 4101 QDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---------SLRLGDRLWLRCA 4151

Query: 274  ADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPA-RKEHSGRYECQGLDLDTMISLL 332
            A G+P P    +  +    E   E   D G  +   A  +E SG Y C            
Sbjct: 4152 ARGSPTPRIGWTVNDRPVTEGVSE--QDGGSTLQRAAVSREDSGTYVCW----------- 4198

Query: 333  SEPQELLVNYVSDVRVSPAAPERQE---------GSSLTLTCEAESSQDLEFQWLRE--- 380
            +E +      VS V V  A   + E         G S+ L C        +  W+++   
Sbjct: 4199 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258

Query: 381  ----ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFK 436
                     L+ G  L +H  +R+  G Y+C+A   +  G+ + ++V + +   P    +
Sbjct: 4259 LRGSHLRHQLQNGS-LTIHRTERDDAGRYQCLAE--NEMGVAK-KVVILVLQSAPVFQVE 4314

Query: 437  ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTL-NVLVTPELLET 495
             + + V+    + L C+A+G P PTI W   G    Q     R L TL +  +  E +ET
Sbjct: 4315 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAG----QPLRASRRLRTLPDGSLWLENVET 4370

Query: 496  G----VECTASNDLGKNTSILFL 514
            G     +C A N LG  T+  FL
Sbjct: 4371 GDAGTYDCVAHNLLGSATARAFL 4393



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 109/480 (22%), Positives = 182/480 (37%), Gaps = 67/480 (13%)

Query: 24   VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQS 83
            VP   E P  E V    GS  +L C +S        V W                     
Sbjct: 3122 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT--VTWLK-----------------DR 3162

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQV 143
             P E      +  RG  L L+++ P     + C  +  +++  +    V      P I+ 
Sbjct: 3163 MPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDF--VVAVLVAPRIRS 3220

Query: 144  NPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYT 203
            + +    +  E +EV      +G P P V W K+G PL ++    H++      S  L  
Sbjct: 3221 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP-HLRFYLDGGSLVLKG 3279

Query: 204  LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYP-TEKVWLEVEPVGML 262
            L++           DA  Y  + +  P+G   +++R  TV V  P T K   +     + 
Sbjct: 3280 LRA----------SDAGAYTCVAHN-PAG---EDARLHTVNVLVPPTIKQGADGSGTLVS 3325

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYEC- 320
            + G+ V + C   G+PP H S  K       ++    + +G  L +   +   +G + C 
Sbjct: 3326 RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 3385

Query: 321  ---------QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQ 371
                     +   L   +  + EP    V + +DV V         GS + L CEA    
Sbjct: 3386 AASPAGVADRNFTLQVQVPPVLEP----VEFQNDVVVV-------RGSLVELPCEARGVP 3434

Query: 372  DLEFQWLREET---GQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                 W+++      Q LE+GP LQL  +     G Y CVA   +       QL    + 
Sbjct: 3435 LPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT---VM 3491

Query: 429  GPPWM--AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNV 486
             PP +  + +  ++ +     + L C+A G P+P I+W+ +G A  + ++  R    L V
Sbjct: 3492 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV 3551



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 122/535 (22%), Positives = 202/535 (37%), Gaps = 96/535 (17%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V VE+G +ALL C  +        V W     + + L  R+  G+G           
Sbjct: 792  PRDVTVELGRSALLACRATGRPPPT--VTWR--RGDGQPLGLRLGAGRGSR--------- 838

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
            S Q     L    V P+D+  ++C+ +    +       +      P I  +   + V  
Sbjct: 839  SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 898

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKE-EKNRVHIQSSQTV-----ESSGLYTLQS 206
             +P  +  C+   G P+P+  W K+GRPL    ++ +    S  +     E +G Y+  +
Sbjct: 899  GQPVSLP-CIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVA 957

Query: 207  ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVT---VPVFYPTEKVWLEVEPVGMLK 263
               A     D       EL  ++P   H   +  +T   VP   P     +    +   K
Sbjct: 958  TNTAGSQHRD------VELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK 1011

Query: 264  EGDRVEIRCLADGNPPPHFSISKQ------NPSTREA----------------------- 294
            E + +  R        PH+++SK+       PS ++A                       
Sbjct: 1012 ETNALTSR-------GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 1064

Query: 295  ---------EEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSD 345
                     EE     +G L L   +   SG YEC            S    L V     
Sbjct: 1065 RLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTA---SNPAGSASHRYVLGVQVPPQ 1121

Query: 346  VRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLE-RGPVLQLH--DLKREAG 402
            V+  P   +   G +L L C AE + + +  W ++  G VL+ RGP   +H   ++    
Sbjct: 1122 VQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKD--GVVLQGRGPQGSVHFAAIRTSDA 1179

Query: 403  GGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK----ENMVLNLSCEASGHP 458
            G YRC AS  +  G++  + V + +  PP     E    ++    EN   +L C A G P
Sbjct: 1180 GRYRCEAS--NSAGVDAWE-VELRVLEPPHWGADETSGLLERVAGEN--ASLPCPARGTP 1234

Query: 459  RPTISWNVNGTASE--QDQDPQRVLSTLNV-LVTPELLETG-VECTASNDLGKNT 509
            +P ++W   G +SE    Q    VL   ++ L +    ++G  EC A+N++G  +
Sbjct: 1235 KPQVTWR-KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTS 1288



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 105/464 (22%), Positives = 174/464 (37%), Gaps = 67/464 (14%)

Query: 82   QSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNI 141
            +S+  + + R+ +  +G TL +  V P+D   + CQ       +       Y  P     
Sbjct: 644  ESQALQEDSRIHVDAQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS--- 699

Query: 142  QVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNG-----RPLKEEKNRVHIQSSQTV 196
             V+ +   V     EE       +G P P+VIWY+ G      P      ++ I ++Q  
Sbjct: 700  -VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQE- 757

Query: 197  ESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLE 255
              +G YT ++      V E  DA    E+   +     + E  R+VTV +          
Sbjct: 758  RDAGTYTCRA------VNELGDAS--AEIQLAVGHAPQLTELPRDVTVEL---------- 799

Query: 256  VEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPS-------TREAEEETTNDNGVLVLE 308
                     G    + C A G PPP  +  + +                   D+GVL  E
Sbjct: 800  ---------GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 850

Query: 309  PARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ--EGSSLTLTCE 366
                E    Y C+  ++      +     L+V   +  +++ +AP  +  EG  ++L C 
Sbjct: 851  SVAPEDQAPYVCEARNV---FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 907

Query: 367  AESSQDL-EFQWLREETGQVLERGP--------VLQLHDLKREAGGGYRCVASVPSIPGL 417
              + + L E  WL++  G+ L  G          L L    +E  G Y CVA+  +  G 
Sbjct: 908  VLAGRPLPERHWLKD--GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT--NTAGS 963

Query: 418  NRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDP 477
                 V + +  PP +          E +  +L C ASG P PTI+W     A       
Sbjct: 964  QHRD-VELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 1022

Query: 478  QRVLSTLNVLVT-PELLETGV-ECTASNDLGKNTSILFLELVNL 519
              V     +L+  P   + G   CTA+N +G ++  + L +  L
Sbjct: 1023 YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRL 1066



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 89/411 (21%), Positives = 151/411 (36%), Gaps = 61/411 (14%)

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNPLGIP 149
            RL + + G  L ++     D   ++C  +    S E    LRV   P    + +  +   
Sbjct: 2891 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 2950

Query: 150  VNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVE-------SSGLY 202
            +NS     V+     + +P P+V WYK+ + L   +    +  + T++        SG+Y
Sbjct: 2951 LNSS----VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 3006

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
            T +++  A      +D Q   +L+  +P             P F    +     +   ++
Sbjct: 3007 TCEALNAA-----GRD-QKLVQLSVLVP-------------PAFRQAPR---GPQDAVLV 3044

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
            + GD+  + C  D  P P  +  K   P       +       L ++ A+    G Y C+
Sbjct: 3045 RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 3104

Query: 322  GLDLDTMISLLSEPQELLVNYVSDVRVSPA-------APERQEGSSLTLTCEAESSQDLE 374
                     + +   E +  +   V+V P           +  GS L LTC+        
Sbjct: 3105 ---------VSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT 3155

Query: 375  FQWLREE-------TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              WL++           V+ RG  LQL  L+    G Y CVA         R   V   +
Sbjct: 3156 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA--RKDFVVAVL 3213

Query: 428  FGPPWMAFK-ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDP 477
              P   +    R+  V E   + L CEA G P P ++W  +G+   QD  P
Sbjct: 3214 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP 3264



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 126/548 (22%), Positives = 193/548 (35%), Gaps = 81/548 (14%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V V V  TALL C        L  V W              R+ +   +P     R 
Sbjct: 3679 PPAVNVSVNQTALLPCQADGVPAPL--VSW--------------RKDRVPLDP--RSPRF 3720

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
             +   G +L +  V  QD   +LC        +   Q R  +  E P I  +P  + + +
Sbjct: 3721 EILPEG-SLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEPPAIAPSPSNLTLTA 3777

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTL--QSILKA 210
              P  +  C   +G P P V+W+K+G+ L     +            G Y L   + L  
Sbjct: 3778 HTP-ALLPCEA-SGSPKPLVVWWKDGQKLDFRLQQ------------GAYRLLPSNALLL 3823

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                    AQF C ++  +   + + +   V VP     ++    V  +        V +
Sbjct: 3824 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMA------PVVL 3876

Query: 271  RCLADGNPPPHFSISKQNPST-REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMI 329
             C + G P P  S SK              + +G L +  A   H+GRY C   +     
Sbjct: 3877 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN---SA 3933

Query: 330  SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE----ETG-- 383
             +  +   L V     V+  P+         + L CEA         W +E     TG  
Sbjct: 3934 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 3993

Query: 384  -QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWV 442
             QVL  G  L++     E  G Y C+A   +   + +T+LV   +  PP +      +  
Sbjct: 3994 TQVLPGGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV---VQVPPVIENGLPDLST 4049

Query: 443  KENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVE---- 498
             E     L C+A G P P I+W+ +G      Q          +  + ELL   +E    
Sbjct: 4050 TEGSHAFLPCKARGSPEPNITWDKDG------QPVSGAEGKFTIQPSGELLVKNLEGQDA 4103

Query: 499  ----CTASNDLG---KNTSILFLELVNLTTLTPDSNTTTG-----LSTSTASPHTRANST 546
                CTA N +G   +   +  L L   TTL  D +   G        +  SP  R   T
Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 4163

Query: 547  STERKLPE 554
              +R + E
Sbjct: 4164 VNDRPVTE 4171



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 69/249 (27%), Positives = 101/249 (40%), Gaps = 21/249 (8%)

Query: 236  KESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISK-QNPSTRE 293
            +  REV + V  P     +E  PV   + E   V + CLA G PPP  S  K   P +  
Sbjct: 1873 ESKREVALKVLVPPN---IEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 1929

Query: 294  AEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAP 353
                 + D  VL +E A+   +G Y C   ++     L      L VN    + + P+ P
Sbjct: 1930 MGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL---RYGLRVNVPPRITLPPSLP 1986

Query: 354  -ERQEGSSLTLTCEAESSQDLEFQWLREETG---------QVLERGPVLQLHDLKREAGG 403
                  + + LTC A  +      WL++            QV   G VL L   +    G
Sbjct: 1987 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSG 2046

Query: 404  GYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTIS 463
             Y CVA   S  G +R  +V + +  PP +  +E  V V  N  + L C++   P P +S
Sbjct: 2047 RYSCVA--VSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 2103

Query: 464  WNVNGTASE 472
            W  +G   E
Sbjct: 2104 WWKDGRPLE 2112



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 54/211 (25%), Positives = 88/211 (41%), Gaps = 22/211 (10%)

Query: 264 EGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ-- 321
           +G  V++ C A G P PH S S+++ + +E      +  G L+++    E +G Y CQ  
Sbjct: 621 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680

Query: 322 ---GLDLDTMISLLSEPQEL-LVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQW 377
              G D +T+    ++P  +  VN V  V V         G    L CEA         W
Sbjct: 681 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAV---------GEEAVLVCEASGVPPPRVIW 731

Query: 378 LREETGQVL----ERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM 433
            R     +L         L++   +    G Y C A V  +   + +  + +A+   P +
Sbjct: 732 YRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELG--DASAEIQLAVGHAPQL 788

Query: 434 AFKERKVWVKENMVLNLSCEASGHPRPTISW 464
               R V V+      L+C A+G P PT++W
Sbjct: 789 TELPRDVTVELGRSALLACRATGRPPPTVTW 819



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 113/479 (23%), Positives = 175/479 (36%), Gaps = 80/479 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNP-LGIPVNSKEP 155
            G  L + Q    D   + C       S E R  LRV   P  P I + P L  PV    P
Sbjct: 1938 GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-NVP--PRITLPPSLPGPVLVNTP 1994

Query: 156  EEVATCVGRNGYPIPQVIWYKNGRPLKEEKN---------RVHIQSSQTVESSGLYTLQS 206
              + TC    G P P ++W K+G P+              RV   +S     SG Y   S
Sbjct: 1995 VRL-TC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY---S 2049

Query: 207  ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
             +    V ED+                     ++V + V  P   +  E+    +  E  
Sbjct: 2050 CVAVSAVGEDR---------------------QDVVLQVHMPPSILGEELNVSVVANES- 2087

Query: 267  RVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDL 325
             V + C +   PPP  S  K   P         + D  +L ++ A    +G Y C+ L+ 
Sbjct: 2088 -VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN- 2145

Query: 326  DTMISLLSEPQELLVNYVSDVRVSPAAPERQ-------EGSSLTLTCEAESSQDLEFQWL 378
                    +      +Y  +V V+P  P R+       EG   +L+CE       +  W 
Sbjct: 2146 --------QAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 2197

Query: 379  REETGQVLER-----------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
            ++  GQ L             G +L L   +    G Y C  S  ++ G N +Q + + +
Sbjct: 2198 KD--GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS--NVVG-NSSQDLQLEV 2252

Query: 428  FGPPWMAFKER---KVWVKENMVLNLSCEASGHPRPTISWNVNG--TASEQDQDPQRVLS 482
              PP +A       +V V ++ V  L C A+G P PT++W  +G    +E     Q    
Sbjct: 2253 HVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 2312

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHT 541
            +L+V            C A N  G+      L ++    L  D +  T ++ +  SP T
Sbjct: 2313 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 2371



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 89/426 (20%), Positives = 159/426 (37%), Gaps = 48/426 (11%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            ++G +L L  V   D   + C       +  R  QL V + P   +    P  + +    
Sbjct: 3453 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED-SGQPTELSLTPGA 3511

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
            P E+       G P P + W+K+G+ L   +N         V  +GLYT  +   A  ++
Sbjct: 3512 PMELLC--DAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIE 3569

Query: 215  EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
            +    +     N   P G           P F            VG+     ++ + C  
Sbjct: 3570 KSFRVRVQAPPNIVGPRG-----------PRFV-----------VGLAP--GQLVLECSV 3605

Query: 275  DGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLS 333
            +  P P  +  +     +E       + G  L L+      SG Y C   +     S+  
Sbjct: 3606 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 3665

Query: 334  EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG--------QV 385
              +   ++ V  +R  P A       +  L C+A+        W ++           ++
Sbjct: 3666 RVE---IHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 3722

Query: 386  LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKEN 445
            L  G  L++  +  +  G Y C+AS  +  G +R Q  ++ +  PP +A     + +  +
Sbjct: 3723 LPEGS-LRIQPVLAQDAGHYLCLAS--NSAGSDR-QGRDLRVLEPPAIAPSPSNLTLTAH 3778

Query: 446  MVLNLSCEASGHPRPTISWNVNGTASE--QDQDPQRVLSTLNVLVTPELLETGV--ECTA 501
                L CEASG P+P + W  +G   +    Q   R+L +  +L+T    +     EC  
Sbjct: 3779 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 3838

Query: 502  SNDLGK 507
            SN++G+
Sbjct: 3839 SNEVGE 3844



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 108/443 (24%), Positives = 167/443 (37%), Gaps = 67/443 (15%)

Query: 101  LALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVA 159
            L + +V  +DE I+ C       +  R + L+V   P   NI+  P+   V   E   V 
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAV--LENASVT 1904

Query: 160  TCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDA 219
                 +G P P V W+K  +P       V      TV   G   +  I +AQL     DA
Sbjct: 1905 LECLASGVPPPDVSWFKGHQP-------VSSWMGVTVSVDG--RVLRIEQAQL----SDA 1951

Query: 220  QFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPP 279
              Y  +   +     ++    V VP      ++ L     G +     V + C A G P 
Sbjct: 1952 GSYRCVASNVAGSTELRYGLRVNVP-----PRITLPPSLPGPVLVNTPVRLTCNATGAPS 2006

Query: 280  PHFSISKQNPSTREAEE---ETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISL 331
            P     K       A     +      VL L  AR   SGRY C      G D   ++  
Sbjct: 2007 PTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ 2066

Query: 332  LSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGP- 390
            +  P  +L     ++ VS  A E     S+ L C++ +       W ++  G+ LE  P 
Sbjct: 2067 VHMPPSIL---GEELNVSVVANE-----SVALECQSHAMPPPVLSWWKD--GRPLEPRPG 2116

Query: 391  --------VLQLHDLKREAGGGYRCVASVPSIPGLNRT----QLVNVAIFGPPWMAFKE- 437
                    +LQ+        G Y C A       LN+     +  N+ ++  P    +E 
Sbjct: 2117 VHLSADKALLQVDRADVWDAGHYTCEA-------LNQAGHSEKHYNLNVWVAPVFPLRES 2169

Query: 438  RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLV---TPELLE 494
              + V+E    +LSCE  G P P ISW  +G     +    + +S +  L+     +L +
Sbjct: 2170 HTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ 2229

Query: 495  TGV-ECTASNDLGKNTSILFLEL 516
             G   C  SN +G ++  L LE+
Sbjct: 2230 EGTYTCECSNVVGNSSQDLQLEV 2252



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 84/334 (25%), Positives = 130/334 (38%), Gaps = 50/334 (14%)

Query: 167  YPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELN 226
            +P P + W K+G P +  +N   +         G + LQ IL AQ  KED   Q+ C + 
Sbjct: 2568 FPSPNITWMKDGAPFEASRNIQLLP--------GTHGLQ-ILNAQ--KEDA-GQYTCVVT 2615

Query: 227  YRLPSGNHMKESR-EVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSI 284
              L  G  +K    EV +P     +    EV    +  K    + + C +   PPP    
Sbjct: 2616 NEL--GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW 2673

Query: 285  SKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISLLSEPQEL 338
             K   P T  +  +   +  +L ++P +   SGRY C      G D      L+  P   
Sbjct: 2674 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP-- 2731

Query: 339  LVNYVSDVRVSPAAPERQE--------------GSSLTLTCEAESSQDLEFQWLREETG- 383
            +   V D   +     R+E               +   L C+  +    +  W RE+   
Sbjct: 2732 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL 2791

Query: 384  ------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKE 437
                   VL+ G VLQ+  ++ E  G Y C AS  +  G +      + +  P  +   E
Sbjct: 2792 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NEVGEDWLHYELLVLTPPVILGDTE 2849

Query: 438  R---KVWVKENMVLNLSCEASGHPRPTISWNVNG 468
                +V V  +  ++L C A G+P PTISW  NG
Sbjct: 2850 ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG 2883



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 103/452 (22%), Positives = 166/452 (36%), Gaps = 49/452 (10%)

Query: 83   SEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRP-RSQEYRIQLRVYKAPE--EP 139
            SEP   +  +++ + G+ L L  V+P D   + CQ      S   R +L VY  P   E 
Sbjct: 1246 SEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRED 1304

Query: 140  NIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKN----GRPLKEEKNRVHIQSSQT 195
              + N  G+   S   E  A     NG+P+P+++W K+    G PL        +   Q 
Sbjct: 1305 GRKANVSGMAGQSLTLECDA-----NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ- 1358

Query: 196  VESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLE 255
            V    L      L    ++E     + C    +  +       R+  + V  P   +   
Sbjct: 1359 VGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTA-----QRDFHLLVLTPPSVLGAG 1413

Query: 256  VEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREA--EEETTNDNGVLVLEPARKE 313
                 +   G  VE++C   G P P    +K            +   D  VL +  +   
Sbjct: 1414 AAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG 1473

Query: 314  HSGRYECQGLD------LDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEA 367
              GRY+C           D  + + + P     N   +V V        E   + L CEA
Sbjct: 1474 DEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAV-------MEDHLVQLLCEA 1526

Query: 368  ESSQDLEFQWLRE------ETGQVLER-GPVLQLHDLKREAGGGYRCVASVPSIPGLNRT 420
                     W ++       T  V  R G  LQL   +    G Y C AS         T
Sbjct: 1527 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKAT 1586

Query: 421  QLVNVAIFGPPWMAFKERKVWVKENMV---LNLSCEASGHPRPTISWNVNG-TASEQDQD 476
            +L    ++ PP +     + +V + +    + L C A GHP PT+SW+  G   +E ++ 
Sbjct: 1587 RL---DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 1643

Query: 477  PQRVLSTLNVLVTPELLETGV-ECTASNDLGK 507
                  ++  L +P    +G+  C AS+  G+
Sbjct: 1644 RLETDGSVLRLESPGEASSGLYSCVASSPAGE 1675



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 108/493 (21%), Positives = 168/493 (34%), Gaps = 53/493 (10%)

Query: 31   PAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQ 90
            P+P  + +   + ALL C  S S   L  V W+   K+ + L FR++QG  +  P     
Sbjct: 3768 PSPSNLTLTAHTPALLPCEASGSPKPL--VVWW---KDGQKLDFRLQQGAYRLLPSN--- 3819

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV 150
                      L LT   PQD   F C       + +R+       P  P I  +     V
Sbjct: 3820 ---------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTV 3868

Query: 151  NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKA 210
                P  V TC    G P P V W K G  L    +   +  S  +E      + +    
Sbjct: 3869 TMMAPV-VLTCHS-TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA---- 3922

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                     ++ C         +          PV  P   V   V         + V +
Sbjct: 3923 --------GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE-------EEVLL 3967

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMIS 330
             C A G P P  +  K+  +            G L +  A  E +G Y C  +  ++  S
Sbjct: 3968 PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC--IAKNSAGS 4025

Query: 331  LLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETG 383
             + + + L+V     +          EGS   L C+A  S +    W ++       E  
Sbjct: 4026 AMGKTR-LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 4084

Query: 384  QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
              ++    L + +L+ +  G Y C A   +  G  R + V++ I   P          ++
Sbjct: 4085 FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRARRR-VHLTILVLPVFTTLPGDRSLR 4141

Query: 444  ENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASN 503
                L L C A G P P I W VN     +    Q   STL              C A N
Sbjct: 4142 LGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 4201

Query: 504  DLGKNTSILFLEL 516
             +G+  ++ F+ +
Sbjct: 4202 RVGRTQAVSFVHV 4214



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 101/508 (19%), Positives = 179/508 (35%), Gaps = 89/508 (17%)

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRP---RSQEYRIQLRV---YK 134
            GQ  PGE      +   G  L L Q     E  + C+        SQ+ ++++ V     
Sbjct: 2200 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 2259

Query: 135  APEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP--------LKEEKN 186
             P EP  QV+ +   V + E           G P P V W ++G+P        L+ +  
Sbjct: 2260 GPREPPTQVSVVQDGVATLE-------CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 2312

Query: 187  RVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVF 246
             +H++ +Q   +     +   L                           +  R+  + V 
Sbjct: 2313 SLHVERAQAAHTGRYSCVAENLAG-------------------------RAERKFELSVL 2347

Query: 247  YPTEKVWLEVEPVGMLKEG--DRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG- 303
             P E +  +++P+  +       + + C A G PPP     +        E+      G 
Sbjct: 2348 VPPELIG-DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW 2406

Query: 304  VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ------- 356
            +L +   +++ SG Y C   +         E  E   N+  +V V P+            
Sbjct: 2407 MLKMTQTQEQDSGLYSCLASN---------EAGEARRNFSVEVLVPPSIENEDLEEVIKV 2457

Query: 357  -EGSSLTLTCEAESSQDLEFQWLREETGQVLERGP---------VLQLHDLKREAGGGYR 406
             +G +  L C        +  W ++  G+ L RG          +LQ+      + G Y 
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 2515

Query: 407  CVASVPSIPGLNRTQLVNVAIFGPPWMAFKE----RKVWVKENMVLNLSCEASGHPRPTI 462
            C+A+  +  G          +  P  +   E     +V V  N  ++L CEA   P P I
Sbjct: 2516 CIAA--NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 2573

Query: 463  SWNVNGTASEQDQDPQRVLST--LNVLVTPELLETGVECTASNDLGKNTSILFLELVNLT 520
            +W  +G   E  ++ Q +  T  L +L   +       C  +N+LG+      +E++   
Sbjct: 2574 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 2633

Query: 521  TLTPDSNTTTGLSTSTASPHTRANSTST 548
            +++ D               T+ NST T
Sbjct: 2634 SISKDDPLG---EVGVKEVKTKVNSTLT 2658



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 118/501 (23%), Positives = 187/501 (37%), Gaps = 106/501 (21%)

Query: 78   QGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPE 137
            +G+    PGE    L+    G  L +TQ   QD  ++ C       +  R        P 
Sbjct: 2388 RGEEPVSPGEDTYLLA---GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP- 2443

Query: 138  EPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKE------EKNRVHIQ 191
             P+I+   L   +   + +         G+P P++ W+K+GRPL          + V +Q
Sbjct: 2444 -PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQ 2502

Query: 192  SSQT-VESSGLYTLQSILKAQLVKED-KDAQFYCELNYRLPSGNHMKESREVTVPVFYPT 249
              Q  + S+G Y   S + A  V E  K  Q    L   +  G       EVTV V  P 
Sbjct: 2503 VLQANLSSAGHY---SCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP- 2558

Query: 250  EKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAE--EETTNDNGVLVL 307
                              + + C A   P P+ +  K       +   +     +G+ +L
Sbjct: 2559 ------------------ISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQIL 2600

Query: 308  EPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPE------------- 354
              A+KE +G+Y C          + +E  E + NY  +V + P+  +             
Sbjct: 2601 N-AQKEDAGQYTCV---------VTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650

Query: 355  RQEGSSLTLTCEAESSQDLEFQWLREETG-------QVLERGPVLQLHDLKREAGGGYRC 407
             +  S+LTL CE+ +      +W ++          QVL  G +LQ+   +    G Y C
Sbjct: 2651 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 2710

Query: 408  VASVPSIPGLNRTQLVNVAIFGPPWM--------AF----KERKV--------WVKENMV 447
            VA+  ++ G    Q  NV I  PP          AF    +E +          + EN  
Sbjct: 2711 VAT--NVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 2767

Query: 448  LNLSCEASGHPRPTISWNVNGTASEQDQ-----DPQRVLSTLNVLVTPELLETGV---EC 499
              L C+ +  P P ++W        +DQ     D   VL    VL  P +         C
Sbjct: 2768 AYLYCDTNAIPPPDLTW------YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 2821

Query: 500  TASNDLGKNTSILFLELVNLT 520
             ASN++G++   L  EL+ LT
Sbjct: 2822 KASNEVGEDW--LHYELLVLT 2840



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 66/253 (26%), Positives = 100/253 (39%), Gaps = 36/253 (14%)

Query: 282 FSISKQNPSTREAEEETTNDNGVLVLEPAR--KEHSGRYECQGLD------LDTMISLLS 333
           F +  +    R  EE    ++G    E  R  K   G YEC  +           I +  
Sbjct: 456 FRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD 515

Query: 334 EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQ 393
            P +L+     +V VSP       G +  L+C           W+R+        G V Q
Sbjct: 516 PPPQLVP--APNVTVSP-------GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ 566

Query: 394 LHDLKREA-------GGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L DL  E        GG Y+CVAS  +  G+ R   V + +   P ++         + +
Sbjct: 567 LADLSLEISGIIPTDGGRYQCVAS--NANGVTRAS-VWLLVREAPQVSIHTSSQHFSQGV 623

Query: 447 VLNLSCEASGHPRPTISWNVNGTASEQDQ----DPQRVLSTLNVLVTPELLETG-VECTA 501
            + +SC ASG+P P ISW+    A ++D     D Q  L      V PE  + G   C A
Sbjct: 624 EVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG--VAPE--DAGNYSCQA 679

Query: 502 SNDLGKNTSILFL 514
           +N++G +   + L
Sbjct: 680 TNEVGTDQETVTL 692



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 107/456 (23%), Positives = 168/456 (36%), Gaps = 72/456 (15%)

Query: 31  PAPELVEVEVGSTALLKCG-LSQSQGNLSHV-DWFSVHKEKRTLIFRVRQGQGQSEPGEY 88
           PAP  V V  G TA+L C  L ++  NL+ V DW       R L          +  G  
Sbjct: 522 PAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDW-------RVL---------PASTGRV 564

Query: 89  EQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRS-QEYRIQLRVYKAPEEPNIQVNPLG 147
            Q   L     +L ++ + P D   + C            + L V +AP     QV+   
Sbjct: 565 AQLADL-----SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP-----QVSIHT 614

Query: 148 IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
              +  +  EV      +GYP P + W +  + L+E+ +R+H+ +  T+   G       
Sbjct: 615 SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED-SRIHVDAQGTLIIQG------- 666

Query: 208 LKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDR 267
               +  ED         NY   + N +   +E TV ++Y        V  V ++  G+ 
Sbjct: 667 ----VAPEDAG-------NYSCQATNEVGTDQE-TVTLYYTDPPSVSAVNAVVLVAVGEE 714

Query: 268 VEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDT 327
             + C A G PPP     +       A E ++  +G L +  A++  +G Y C+ ++   
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCRAVN--- 769

Query: 328 MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL- 386
            +   S   +L V +   +   P     + G S  L C A         W R + GQ L 
Sbjct: 770 ELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD-GQPLG 828

Query: 387 ----------ERGP---VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM 433
                      R P   VL    +  E    Y C A           +L+ V    PP +
Sbjct: 829 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLI-VTGHAPPQI 887

Query: 434 AFKERKVWVKENMVLNLSC-EASGHPRPTISWNVNG 468
           A     V V E   ++L C   +G P P   W  +G
Sbjct: 888 ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 923



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 56/230 (24%), Positives = 88/230 (38%), Gaps = 25/230 (10%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVN 151
            +S QD G+TL    V+ +D   ++C  +    +   +     K  E P +Q       V 
Sbjct: 4173 VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK--EAPVLQGEAFSYLVE 4230

Query: 152  SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
                     CV R G P+P + W K+G PL+    R  +Q+               L   
Sbjct: 4231 PVGGSIQLDCVVR-GDPVPDIHWIKDGLPLRGSHLRHQLQNGS-------------LTIH 4276

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEI 270
              + D   ++ C         N M  +++V + V         +VEP  M ++ GD V +
Sbjct: 4277 RTERDDAGRYQCLAE------NEMGVAKKVVILVLQSAPV--FQVEPQDMTVRSGDDVAL 4328

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
            RC A G P P     +     R +    T  +G L LE      +G Y+C
Sbjct: 4329 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDC 4378



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 108/449 (24%), Positives = 170/449 (37%), Gaps = 69/449 (15%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
            G +L L  +   D   + C    P  ++ R+       P  P I+    G       P E
Sbjct: 3272 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVP--PTIKQGADGSGTLVSRPGE 3329

Query: 158  VAT--CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKE 215
            + T  C  R   PI  V W K+G PL          S +T+     +TL+ I K QL   
Sbjct: 3330 LVTMVCPVRGSPPI-HVSWLKDGLPLP--------LSQRTLLHGSGHTLR-ISKVQLADA 3379

Query: 216  DKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD 275
                 F C      P+G      R  T+ V  P     +E +   ++  G  VE+ C A 
Sbjct: 3380 ---GIFTCVA--ASPAG---VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEAR 3431

Query: 276  GNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LDTM 328
            G P P  S  K   P   ++ E+  +    L LE      SG Y C  +           
Sbjct: 3432 GVPLPLVSWMKDGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 3487

Query: 329  ISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLER 388
            ++++  P        +++ ++P AP       + L C+A+ +      W ++  GQ L R
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAP-------MELLCDAQGTPQPNITWHKD--GQALTR 3538

Query: 389  -------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVA----IFGPPWMAFKE 437
                     VL++ D      G Y C+A  P+   + ++  V V     I GP    F  
Sbjct: 3539 LENNSRATRVLRVRD-----AGLYTCLAESPA-GAIEKSFRVRVQAPPNIVGPRGPRFV- 3591

Query: 438  RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQD---QDPQR-VLSTLNVLVTPELL 493
              V +    ++ L C     P P I+W+ +G   ++D   Q P+R     L  L T +  
Sbjct: 3592 --VGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD-- 3646

Query: 494  ETGVECTASNDLGKNTSILFLELVNLTTL 522
                 CTA N  G  +    +E+  + T+
Sbjct: 3647 SGDYSCTARNAAGSTSVAFRVEIHTVPTI 3675



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 90/394 (22%), Positives = 146/394 (37%), Gaps = 56/394 (14%)

Query: 98   GATLALTQVTPQDERIFLCQGKRP-RSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPE 156
            G  L L +    D  ++ C+      + E   +L VY  P        P  +   +  P 
Sbjct: 1555 GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPV 1614

Query: 157  EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
             +  CV R G+P P + W+  G P+ E               S L T  S+L+ +   E 
Sbjct: 1615 ALE-CVAR-GHPSPTLSWHHEGLPVAESNE------------SRLETDGSVLRLESPGEA 1660

Query: 217  KDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLEVEPVGMLKE--GDRVEIRCL 273
                + C  +   P+G  + + S EV VP         L  E +G +    G  +E+ C 
Sbjct: 1661 SSGLYSCVASS--PAGEAVLQYSVEVQVP------PQLLVAEGLGQVTTIVGQPLELPCQ 1712

Query: 274  ADGNPPPHFS-ISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LD 326
            A G+P P    +    P+   A  +  +    L ++    +HSG + CQ  +       +
Sbjct: 1713 ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 1772

Query: 327  TMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCE--------AESSQDLEFQWL 378
              +S+  E        V +V +       +  SS    C+        A     L   W 
Sbjct: 1773 VEVSVHGE----WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 1828

Query: 379  R------EETGQVLERG--PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
                   E TG  +     P LQ+  +     G Y C A+  ++ G ++ + V + +  P
Sbjct: 1829 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKRE-VALKVLVP 1885

Query: 431  PWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
            P +        V EN  + L C ASG P P +SW
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW 1919



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 90/427 (21%), Positives = 157/427 (36%), Gaps = 37/427 (8%)

Query: 94   LQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSK 153
            L D G +L   ++   D  ++ C+ +       R    +   P  P++        V   
Sbjct: 1364 LLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTP--PSVLGAGAAQEVLGL 1421

Query: 154  EPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSS-QTVESSGLYTLQSILKAQL 212
               +V      +G P PQV W K+ +P+      + +Q   Q +  +G +          
Sbjct: 1422 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--------- 1472

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIR 271
                 + ++ C      P+G   +++R+  + V  P   +W   E   + + E   V++ 
Sbjct: 1473 ---GDEGRYQCVAFS--PAG---QQARDFQLRVHAPPT-IWGSNETGEVAVMEDHLVQLL 1523

Query: 272  CLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMIS 330
            C A G P P+ +  K       + +      G  L L  A+   +G Y C+  +      
Sbjct: 1524 CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE 1583

Query: 331  LLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETG 383
              +     +   +      P   +   G  + L C A         W  E          
Sbjct: 1584 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 1643

Query: 384  QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKER--KVW 441
            ++   G VL+L      + G Y CVAS P+   + +    +V +  PP +   E   +V 
Sbjct: 1644 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---YSVEVQVPPQLLVAEGLGQVT 1700

Query: 442  VKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVT-PELLETGV-EC 499
                  L L C+ASG P PTI W  NG  +E+    Q       + +   EL  +G+  C
Sbjct: 1701 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 1760

Query: 500  TASNDLG 506
             A+N+ G
Sbjct: 1761 QATNEAG 1767



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 55/216 (25%), Positives = 85/216 (39%), Gaps = 31/216 (14%)

Query: 265  GDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ--- 321
            G+ +++ C+A+GNP P  S SK          +     G +     R   +GRY C+   
Sbjct: 1134 GEALDLNCVAEGNPEPQLSWSKDG-----VVLQGRGPQGSVHFAAIRTSDAGRYRCEASN 1188

Query: 322  --GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLR 379
              G+D   +   + EP     +  S +       ER  G + +L C A  +   +  W +
Sbjct: 1189 SAGVDAWEVELRVLEPPHWGADETSGLL------ERVAGENASLPCPARGTPKPQVTWRK 1242

Query: 380  EETGQ---------VLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
              + +         VLE G  L L  +     G Y C A+        R +LV   ++ P
Sbjct: 1243 GPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRAKLV---VYVP 1298

Query: 431  PWMAFKERKVWVK--ENMVLNLSCEASGHPRPTISW 464
            P +    RK  V       L L C+A+G P P I W
Sbjct: 1299 PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVW 1334



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 95/399 (23%), Positives = 144/399 (36%), Gaps = 73/399 (18%)

Query: 100  TLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEV 158
            +L L QV   D   + C    P  S  +R  L V   P+   +Q  P  + V   E  ++
Sbjct: 1083 SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQ---VQPGPRVLKVLVGEALDL 1139

Query: 159  ATCVGRNGYPIPQVIWYKNGRPLKEE--KNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
              CV   G P PQ+ W K+G  L+    +  VH  + +T ++                  
Sbjct: 1140 -NCVAE-GNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTSDAG----------------- 1180

Query: 217  KDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKE--GDRVEIRCLA 274
               ++ CE      S +   ++ EV + V  P    W   E  G+L+   G+   + C A
Sbjct: 1181 ---RYRCEA-----SNSAGVDAWEVELRVLEPPH--WGADETSGLLERVAGENASLPCPA 1230

Query: 275  DGNPPPHFSISKQNPSTREAEEE---TTNDNGVLVLEPARKEHSGRYECQGLDLDTMISL 331
             G P P  +  K  PS+     +      + G L L       SG YECQ  +    +  
Sbjct: 1231 RGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATN---EVGS 1286

Query: 332  LSEPQELLVNYVSDVRVS--PAAPERQEGSSLTLTCEAESSQDLEFQWLREET------- 382
             S   +L+V     +R     A      G SLTL C+A      E  WL++         
Sbjct: 1287 TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLG 1346

Query: 383  ----------GQV-----LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
                      GQV     L+ G  L    ++    G Y C A   +        L+   +
Sbjct: 1347 WAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLL---V 1403

Query: 428  FGPPWM--AFKERKVWVKENMVLNLSCEASGHPRPTISW 464
              PP +  A   ++V       + L C  SG P P + W
Sbjct: 1404 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 1442



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 69/312 (22%), Positives = 115/312 (36%), Gaps = 37/312 (11%)

Query: 166  GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCEL 225
            G P+P + W +NG P         ++  Q            +L+    +    A + C  
Sbjct: 2871 GNPVPTISWLQNGLPFSPSPRLQVLEDGQ------------VLQVSTAEVADAASYMCVA 2918

Query: 226  NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSIS 285
              +  S   +      T+ V  P     L++E V  +     V + C    +P P  +  
Sbjct: 2919 ENQAGSAEKL-----FTLRVQVPPRIAGLDLEQVTAILNSS-VSLPCDVHAHPNPEVTWY 2972

Query: 286  KQNPSTREAEEE-TTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS 344
            K + +    EE         L L  AR   SG Y C+ L+       L    +L V    
Sbjct: 2973 KDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPP 3029

Query: 345  DVRVSPAAPER----QEGSSLTLTCEAESSQDLEFQWLRE-------ETGQVLERGPVLQ 393
              R +P  P+     + G    L+CE ++  +    W ++       +  Q L  G  L+
Sbjct: 3030 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 3089

Query: 394  LHDLKREAGGGYRCVASVPSIPG-LNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSC 452
            + + +    G Y C   V ++ G   RT  + V +  P +   K   V       L L+C
Sbjct: 3090 IQEAQVSDKGLYSC--KVSNVAGEAVRTFTLTVQV-PPTFENPKTETVSQVAGSPLVLTC 3146

Query: 453  EASGHPRPTISW 464
            + SG P PT++W
Sbjct: 3147 DVSGVPAPTVTW 3158



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 94/447 (21%), Positives = 164/447 (36%), Gaps = 59/447 (13%)

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPEEPNIQ 142
            +P   E  L LQ++G +L + +        + C  +    + E + +L V   PE     
Sbjct: 2297 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIG-D 2355

Query: 143  VNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLY 202
            ++PL     +        C    G P P + W++   P+               E + L 
Sbjct: 2356 LDPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGEEPVSPG------------EDTYLL 2402

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
                +LK    +E     + C     L S    +  R  +V V  P      ++E V  +
Sbjct: 2403 AGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 2457

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLV-LEPARKEHSGRYECQ 321
             +G    + C   G+P P  +  K        +    + +GVL+ +  A    +G Y C 
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517

Query: 322  GLDL------DTMISLLSEPQELL-VNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLE 374
              +          +S+L  P  L      +D  V+         + ++L CEA +     
Sbjct: 2518 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV-----NNPISLICEALAFPSPN 2572

Query: 375  FQWLREETG-------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              W+++          Q+L     LQ+ + ++E  G Y CV +      +      +V +
Sbjct: 2573 ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN---YHVEV 2629

Query: 428  FGPPWMAFKE-------RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV 480
              PP ++  +       ++V  K N  L L CE+   P PTI W        +D  P   
Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-------YKDGQPVTP 2682

Query: 481  LSTLNVLVTPELLETGVECTASNDLGK 507
             S L VL    LL+  ++ T  +D G+
Sbjct: 2683 SSRLQVLGEGRLLQ--IQPTQVSDSGR 2707



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 86/400 (21%), Positives = 133/400 (33%), Gaps = 73/400 (18%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPR---SQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
            +RG  L L  ++  D   + C  +      S  +R+++        P I+  P  + V+ 
Sbjct: 3632 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-----PTIRSGPPAVNVSV 3686

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL 212
             +   +  C   +G P P V W K+  PL     R  I              +  L+ Q 
Sbjct: 3687 NQTA-LLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILP------------EGSLRIQP 3732

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPT-EKVWLEVEPVGMLKEGDRVEIR 271
            V       + C  +    S    ++ R +  P   P+   + L      +L         
Sbjct: 3733 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP-------- 3784

Query: 272  CLADGNPPPHFSISKQNPST----REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDT 327
            C A G+P P     K         ++        N +L+  P  ++ S ++EC       
Sbjct: 3785 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD-SAQFEC------V 3837

Query: 328  MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLT------LTCEAESSQDLEFQW---- 377
            + + + E   L   Y   V V P   + Q   ++T      LTC +         W    
Sbjct: 3838 VSNEVGEAHRL---YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG 3894

Query: 378  ---------LREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                      R      LE G  L +H       G Y C  S  +  G+    +      
Sbjct: 3895 AQLGARGSGYRVSPSGALEIGQALPIH------AGRYTC--SARNSAGVAHKHVFLTVQA 3946

Query: 429  GPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             P           V E  VL L CEASG PRPTI+W   G
Sbjct: 3947 SPVVKPLPSVVRAVAEEEVL-LPCEASGIPRPTITWQKEG 3985


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 94/401 (23%), Positives = 153/401 (38%), Gaps = 30/401 (7%)

Query: 139 PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES 198
           P I  +P  + V+  EP  +  C    G P P + WYK G  ++ +K+    +S + +  
Sbjct: 68  PRIVEHPSDLIVSKGEPATL-NCKAE-GRPTPTIEWYKGGERVETDKDDP--RSHRMLLP 123

Query: 199 SGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEP 258
           SG      I+  +  + D+        NY   + +H   S EV +         + +   
Sbjct: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH-NASLEVAI-----LRDDFRQNPS 177

Query: 259 VGMLKEGDRVEIRCLAD-GNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGR 317
             M+  G+   + C    G+P P  S  K      + +E  T   G L++   RK  +G+
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237

Query: 318 YECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQW 377
           Y C G ++  +    SE  EL V         P+        S    CEA        +W
Sbjct: 238 YVCVGTNM--VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295

Query: 378 LREETGQVLERGPVLQLHDLKRE---AG--GGYRCVASVPSIPGLNRTQLVNVAIFGPPW 432
            +++      R  +   H LK     AG  G Y CVA   ++ G        + +  PP 
Sbjct: 296 RKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE--NMVGKAEAS-ATLTVQEPPH 352

Query: 433 MAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQ-DQDPQRVLSTLNVLVTPE 491
              K R   V     +   CEA+G+P+P I W   G+ +      P +  S  +V  T +
Sbjct: 353 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412

Query: 492 LLETGVE--------CTASNDLGKNTSILFLELVNLTTLTP 524
           L  T V+        C   N  G   +  +LE+ ++    P
Sbjct: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 453



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 110/479 (22%), Positives = 177/479 (36%), Gaps = 67/479 (13%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE +++C  +    +       +  A    + + NP  + V   EP  V  C    G+P 
Sbjct: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA-VMECQPPRGHPE 199

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+G PL ++  R+ I+  + + +   YT +S           DA  Y  +    
Sbjct: 200 PTISWKKDGSPLDDKDERITIRGGKLMIT---YTRKS-----------DAGKYVCV---- 241

Query: 230 PSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQN 288
             G +M   RE  V      E+      P  + +   D  E +C A G+P P     K +
Sbjct: 242 --GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 299

Query: 289 PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRV 348
               ++  E  +D+  L +        G Y C     + M+        L V       V
Sbjct: 300 GELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVA---ENMVGKAEASATLTVQEPPHFVV 355

Query: 349 SPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPVLQLHDL-- 397
            P       G ++T  CEA  +      W RE +  +L          R  V Q  DL  
Sbjct: 356 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415

Query: 398 ---KREAGGGYRC-----VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLN 449
              +R   G Y C       S+ +   L  T ++  A   PP +        V  +    
Sbjct: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI--ADRPPPVIRQGPVNQTVAVDGTFV 473

Query: 450 LSCEASGHPRPTISWNVNGT-ASEQDQDPQRVLSTLNVLVTPELLETG-VECTASNDLGK 507
           LSC A+G P PTI W  +G   S QD   +++ + +  +   +L +TG   C AS   G+
Sbjct: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533

Query: 508 NTSILFLEL--------------VNLTTLTPDSNTTTGLSTSTAS----PHTRANSTST 548
            T   ++E+               NL    P     T +S +T +    P+  + +T T
Sbjct: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 592



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 17/50 (34%), Positives = 23/50 (46%)

Query: 430 PPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQR 479
           PP +      + V +     L+C+A G P PTI W   G   E D+D  R
Sbjct: 67  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 109/480 (22%), Positives = 182/480 (37%), Gaps = 67/480 (13%)

Query: 24   VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQS 83
            VP   E P  E V    GS  +L C +S        V W                     
Sbjct: 1840 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT--VTWLK-----------------DR 1880

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQV 143
             P E      +  RG  L L+++ P     + C  +  +++  +    V      P I+ 
Sbjct: 1881 MPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDF--VVAVLVAPRIRS 1938

Query: 144  NPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYT 203
            + +    +  E +EV      +G P P V W K+G PL ++    H++      S  L  
Sbjct: 1939 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP-HLRFYLDGGSLVLKG 1997

Query: 204  LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYP-TEKVWLEVEPVGML 262
            L++           DA  Y  + +  P+G   +++R  TV V  P T K   +     + 
Sbjct: 1998 LRA----------SDAGAYTCVAHN-PAG---EDARLHTVNVLVPPTIKQGADGSGTLVS 2043

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYEC- 320
            + G+ V + C   G+PP H S  K       ++    + +G  L +   +   +G + C 
Sbjct: 2044 RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2103

Query: 321  ---------QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQ 371
                     +   L   +  + EP    V + +DV V         GS + L CEA    
Sbjct: 2104 AASPAGVADRNFTLQVQVPPVLEP----VEFQNDVVVV-------RGSLVELPCEARGVP 2152

Query: 372  DLEFQWLREET---GQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                 W+++      Q LE+GP LQL  +     G Y CVA   +       QL    + 
Sbjct: 2153 LPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLT---VM 2209

Query: 429  GPPWM--AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNV 486
             PP +  + +  ++ +     + L C+A G P+P I+W+ +G A  + ++  R    L V
Sbjct: 2210 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRV 2269



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 103/443 (23%), Positives = 171/443 (38%), Gaps = 74/443 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIP-VNSKEPE 156
            G  L +   +P+D   +LC  K            V + P      V   G+P +++ E  
Sbjct: 2717 GGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPP-----VIENGLPDLSTTEGS 2771

Query: 157  EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
                     G P P + W K+G+P+   + +       T++ SG   ++++       E 
Sbjct: 2772 HAFLPCKARGSPEPNITWDKDGQPVSGAEGKF------TIQPSGELLVKNL-------EG 2818

Query: 217  KDAQFY-CELNYRLPSGNHMKESREVTVPVF--YPTEKVWLEVEPVGMLKEGDRVEIRCL 273
            +DA  Y C     +           + +PVF   P ++          L+ GDR+ +RC 
Sbjct: 2819 QDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDR---------SLRLGDRLWLRCA 2869

Query: 274  ADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPA-RKEHSGRYECQGLDLDTMISLL 332
            A G+P P    +  +    E   E   D G  +   A  +E SG Y C            
Sbjct: 2870 ARGSPTPRIGWTVNDRPVTEGVSE--QDGGSTLQRAAVSREDSGTYVCW----------- 2916

Query: 333  SEPQELLVNYVSDVRVSPAAPERQE---------GSSLTLTCEAESSQDLEFQWLRE--- 380
            +E +      VS V V  A   + E         G S+ L C        +  W+++   
Sbjct: 2917 AENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976

Query: 381  ----ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFK 436
                     L+ G  L +   +R+  G Y+C+A   +  G+ + ++V + +   P    +
Sbjct: 2977 LRGSHLRHQLQNGS-LTIRRTERDDAGRYQCLAE--NEMGVAK-KVVILVLQSAPVFQVE 3032

Query: 437  ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTL-NVLVTPELLET 495
             + + V+    + L C+A+G P PTI W   G    Q     R L TL +  +  E +ET
Sbjct: 3033 PQDMTVRSGDDVALRCQATGEPTPTIEWLQAG----QPLRASRRLRTLPDGSLWLENVET 3088

Query: 496  G----VECTASNDLGKNTSILFL 514
            G     +C A N LG  T+  FL
Sbjct: 3089 GDAGTYDCVAHNLLGSATARAFL 3111



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 89/411 (21%), Positives = 151/411 (36%), Gaps = 61/411 (14%)

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNPLGIP 149
            RL + + G  L ++     D   ++C  +    S E    LRV   P    + +  +   
Sbjct: 1609 RLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI 1668

Query: 150  VNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVE-------SSGLY 202
            +NS     V+     + +P P+V WYK+ + L   +    +  + T++        SG+Y
Sbjct: 1669 LNSS----VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1724

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
            T +++  A      +D Q   +L+  +P             P F    +     +   ++
Sbjct: 1725 TCEALNAA-----GRD-QKLVQLSVLVP-------------PAFRQAPR---GPQDAVLV 1762

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
            + GD+  + C  D  P P  +  K   P       +       L ++ A+    G Y C+
Sbjct: 1763 RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 1822

Query: 322  GLDLDTMISLLSEPQELLVNYVSDVRVSPA-------APERQEGSSLTLTCEAESSQDLE 374
                     + +   E +  +   V+V P           +  GS L LTC+        
Sbjct: 1823 ---------VSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT 1873

Query: 375  FQWLREE-------TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              WL++           V+ RG  LQL  L+    G Y CVA         R   V   +
Sbjct: 1874 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA--RKDFVVAVL 1931

Query: 428  FGPPWMAFK-ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDP 477
              P   +    R+  V E   + L CEA G P P ++W  +G+   QD  P
Sbjct: 1932 VAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGP 1982



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 126/548 (22%), Positives = 193/548 (35%), Gaps = 81/548 (14%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V V V  TALL C        L  V W              R+ +   +P     R 
Sbjct: 2397 PPAVNVSVNQTALLPCQADGVPAPL--VSW--------------RKDRVPLDP--RSPRF 2438

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
             +   G +L +  V  QD   +LC        +   Q R  +  E P I  +P  + + +
Sbjct: 2439 EILPEG-SLRIQPVLAQDAGHYLCLASNSAGSDR--QGRDLRVLEPPAIAPSPSNLTLTA 2495

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTL--QSILKA 210
              P  +  C   +G P P V+W+K+G+ L     +            G Y L   + L  
Sbjct: 2496 HTP-ALLPCEA-SGSPKPLVVWWKDGQKLDFRLQQ------------GAYRLLPSNALLL 2541

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                    AQF C ++  +   + + +   V VP     ++    V  +        V +
Sbjct: 2542 TAPGPQDSAQFECVVSNEVGEAHRLYQV-TVHVPPTIADDQTDFTVTMMA------PVVL 2594

Query: 271  RCLADGNPPPHFSISKQNPST-REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMI 329
             C + G P P  S SK              + +G L +  A   H+GRY C   +     
Sbjct: 2595 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN---SA 2651

Query: 330  SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE----ETG-- 383
             +  +   L V     V+  P+         + L CEA         W +E     TG  
Sbjct: 2652 GVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2711

Query: 384  -QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWV 442
             QVL  G  L++     E  G Y C+A   +   + +T+LV   +  PP +      +  
Sbjct: 2712 TQVLPGGQ-LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLV---VQVPPVIENGLPDLST 2767

Query: 443  KENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVE---- 498
             E     L C+A G P P I+W+ +G      Q          +  + ELL   +E    
Sbjct: 2768 TEGSHAFLPCKARGSPEPNITWDKDG------QPVSGAEGKFTIQPSGELLVKNLEGQDA 2821

Query: 499  ----CTASNDLG---KNTSILFLELVNLTTLTPDSNTTTG-----LSTSTASPHTRANST 546
                CTA N +G   +   +  L L   TTL  D +   G        +  SP  R   T
Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT 2881

Query: 547  STERKLPE 554
              +R + E
Sbjct: 2882 VNDRPVTE 2889



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 69/249 (27%), Positives = 101/249 (40%), Gaps = 21/249 (8%)

Query: 236 KESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISK-QNPSTRE 293
           +  REV + V  P     +E  PV   + E   V + CLA G PPP  S  K   P +  
Sbjct: 591 ESKREVALKVLVPPN---IEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSW 647

Query: 294 AEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAP 353
                + D  VL +E A+   +G Y C   ++     L      L VN    + + P+ P
Sbjct: 648 MGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL---RYGLRVNVPPRITLPPSLP 704

Query: 354 -ERQEGSSLTLTCEAESSQDLEFQWLREETG---------QVLERGPVLQLHDLKREAGG 403
                 + + LTC A  +      WL++            QV   G VL L   +    G
Sbjct: 705 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSG 764

Query: 404 GYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTIS 463
            Y CVA   S  G +R  +V + +  PP +  +E  V V  N  + L C++   P P +S
Sbjct: 765 RYSCVA--VSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLS 821

Query: 464 WNVNGTASE 472
           W  +G   E
Sbjct: 822 WWKDGRPLE 830



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 113/479 (23%), Positives = 174/479 (36%), Gaps = 80/479 (16%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPR-SQEYRIQLRVYKAPEEPNIQVNP-LGIPVNSKEP 155
            G  L + Q    D   + C       S E R  LRV   P  P I + P L  PV    P
Sbjct: 656  GRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-NVP--PRITLPPSLPGPVLVNTP 712

Query: 156  EEVATCVGRNGYPIPQVIWYKNGRPLKEEKN---------RVHIQSSQTVESSGLYTLQS 206
              + TC    G P P ++W K+G P+              RV   +S     SG Y   S
Sbjct: 713  VRL-TC-NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY---S 767

Query: 207  ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
             +    V ED+                     ++V + V  P   +  E+    +  E  
Sbjct: 768  CVAVSAVGEDR---------------------QDVVLQVHMPPSILGEELNVSVVANES- 805

Query: 267  RVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDL 325
             V + C +   PPP  S  K   P         + D  +L ++ A    +G Y C+ L+ 
Sbjct: 806  -VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALN- 863

Query: 326  DTMISLLSEPQELLVNYVSDVRVSPAAPERQ-------EGSSLTLTCEAESSQDLEFQWL 378
                    +      +Y  +V V+P  P R+       EG    L+CE       +  W 
Sbjct: 864  --------QAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWR 915

Query: 379  REETGQVLER-----------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
            ++  GQ L             G +L L   +    G Y C  S  ++ G N +Q + + +
Sbjct: 916  KD--GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS--NVVG-NSSQDLQLEV 970

Query: 428  FGPPWMAFKER---KVWVKENMVLNLSCEASGHPRPTISWNVNG--TASEQDQDPQRVLS 482
              PP +A       +V V ++ V  L C A+G P PT++W  +G    +E     Q    
Sbjct: 971  HVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1030

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHT 541
            +L+V            C A N  G+      L ++    L  D +  T ++ +  SP T
Sbjct: 1031 SLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLT 1089



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 84/334 (25%), Positives = 130/334 (38%), Gaps = 50/334 (14%)

Query: 167  YPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELN 226
            +P P + W K+G P +  +N   +         G + LQ IL AQ  KED   Q+ C + 
Sbjct: 1286 FPSPNITWMKDGAPFEASRNIQLLP--------GTHGLQ-ILNAQ--KEDA-GQYTCVVT 1333

Query: 227  YRLPSGNHMKESR-EVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSI 284
              L  G  +K    EV +P     +    EV    +  K    + + C +   PPP    
Sbjct: 1334 NEL--GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRW 1391

Query: 285  SKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISLLSEPQEL 338
             K   P T  +  +   +  +L ++P +   SGRY C      G D      L+  P   
Sbjct: 1392 YKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP-- 1449

Query: 339  LVNYVSDVRVSPAAPERQE--------------GSSLTLTCEAESSQDLEFQWLREETG- 383
            +   V D   +     R+E               +   L C+  +    +  W RE+   
Sbjct: 1450 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL 1509

Query: 384  ------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKE 437
                   VL+ G VLQ+  ++ E  G Y C AS  +  G +      + +  P  +   E
Sbjct: 1510 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKAS--NEVGEDWLHYELLVLTPPVILGDTE 1567

Query: 438  R---KVWVKENMVLNLSCEASGHPRPTISWNVNG 468
                +V V  +  ++L C A G+P PTISW  NG
Sbjct: 1568 ELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG 1601



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 89/426 (20%), Positives = 159/426 (37%), Gaps = 48/426 (11%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKE 154
            ++G +L L  V   D   + C       +  R  QL V + P   +    P  + +    
Sbjct: 2171 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIED-SGQPTELSLTPGA 2229

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
            P E+       G P P + W+K+G+ L   +N         V  +GLYT  +   A  ++
Sbjct: 2230 PMELLC--DAQGTPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIE 2287

Query: 215  EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
            +    +     N   P G           P F            VG+     ++ + C  
Sbjct: 2288 KSFRVRVQAPPNIVGPRG-----------PRFV-----------VGLAP--GQLVLECSV 2323

Query: 275  DGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMISLLS 333
            +  P P  +  +     +E       + G  L L+      SG Y C   +     S+  
Sbjct: 2324 EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAF 2383

Query: 334  EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG--------QV 385
              +   ++ V  +R  P A       +  L C+A+        W ++           ++
Sbjct: 2384 RVE---IHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEI 2440

Query: 386  LERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKEN 445
            L  G  L++  +  +  G Y C+AS  +  G +R Q  ++ +  PP +A     + +  +
Sbjct: 2441 LPEGS-LRIQPVLAQDAGHYLCLAS--NSAGSDR-QGRDLRVLEPPAIAPSPSNLTLTAH 2496

Query: 446  MVLNLSCEASGHPRPTISWNVNGTASE--QDQDPQRVLSTLNVLVTPELLETGV--ECTA 501
                L CEASG P+P + W  +G   +    Q   R+L +  +L+T    +     EC  
Sbjct: 2497 TPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVV 2556

Query: 502  SNDLGK 507
            SN++G+
Sbjct: 2557 SNEVGE 2562



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 108/443 (24%), Positives = 166/443 (37%), Gaps = 67/443 (15%)

Query: 101 LALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVA 159
           L + +V  +DE I+ C       +  R + L+V   P   NI+  P+   V   E   V 
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NIEPGPVNKAV--LENASVT 622

Query: 160 TCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDA 219
                +G P P V W+K  +P       V      TV   G   +  I +AQL     DA
Sbjct: 623 LECLASGVPPPDVSWFKGHQP-------VSSWMGVTVSVDG--RVLRIEQAQL----SDA 669

Query: 220 QFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPP 279
             Y  +   +     ++    V VP      ++ L     G +     V + C A G P 
Sbjct: 670 GSYRCVASNVAGSTELRYGLRVNVP-----PRITLPPSLPGPVLVNTPVRLTCNATGAPS 724

Query: 280 PHFSISKQNPSTREAEE---ETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDTMISL 331
           P     K       A     +      VL L  AR   SGRY C      G D   ++  
Sbjct: 725 PTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQ 784

Query: 332 LSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGP- 390
           +  P  +L     ++ VS  A E     S+ L C++ +       W ++  G+ LE  P 
Sbjct: 785 VHMPPSIL---GEELNVSVVANE-----SVALECQSHAMPPPVLSWWKD--GRPLEPRPG 834

Query: 391 --------VLQLHDLKREAGGGYRCVASVPSIPGLNRT----QLVNVAIFGPPWMAFKE- 437
                   +LQ+        G Y C A       LN+     +  N+ ++  P    +E 
Sbjct: 835 VHLSADKALLQVDRADVWDAGHYTCEA-------LNQAGHSEKHYNLNVWVAPVFPLRES 887

Query: 438 RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLV---TPELLE 494
             + V+E     LSCE  G P P ISW  +G     +    + +S +  L+     +L +
Sbjct: 888 HTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQ 947

Query: 495 TGV-ECTASNDLGKNTSILFLEL 516
            G   C  SN +G ++  L LE+
Sbjct: 948 EGTYTCECSNVVGNSSQDLQLEV 970



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 101/508 (19%), Positives = 179/508 (35%), Gaps = 89/508 (17%)

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRP---RSQEYRIQLRV---YK 134
            GQ  PGE      +   G  L L Q     E  + C+        SQ+ ++++ V     
Sbjct: 918  GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 977

Query: 135  APEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP--------LKEEKN 186
             P EP  QV+ +   V + E           G P P V W ++G+P        L+ +  
Sbjct: 978  GPREPPTQVSVVQDGVATLE-------CNATGKPPPTVTWERDGQPVGAELGLQLQNQGQ 1030

Query: 187  RVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVF 246
             +H++ +Q   +     +   L                           +  R+  + V 
Sbjct: 1031 SLHVERAQAAHTGRYSCVAENLAG-------------------------RAERKFELSVL 1065

Query: 247  YPTEKVWLEVEPVGMLKEG--DRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNG- 303
             P E +  +++P+  +       + + C A G PPP     +        E+      G 
Sbjct: 1066 VPPELIG-DLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGW 1124

Query: 304  VLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ------- 356
            +L +   +++ SG Y C   +         E  E   N+  +V V P+            
Sbjct: 1125 MLKMTQTQEQDSGLYSCLASN---------EAGEARRNFSVEVLVPPSIENEDLEEVIKV 1175

Query: 357  -EGSSLTLTCEAESSQDLEFQWLREETGQVLERGP---------VLQLHDLKREAGGGYR 406
             +G +  L C        +  W ++  G+ L RG          +LQ+      + G Y 
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKD--GRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1233

Query: 407  CVASVPSIPGLNRTQLVNVAIFGPPWMAFKE----RKVWVKENMVLNLSCEASGHPRPTI 462
            C+A+  +  G          +  P  +   E     +V V  N  ++L CEA   P P I
Sbjct: 1234 CIAA--NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNI 1291

Query: 463  SWNVNGTASEQDQDPQRVLST--LNVLVTPELLETGVECTASNDLGKNTSILFLELVNLT 520
            +W  +G   E  ++ Q +  T  L +L   +       C  +N+LG+      +E++   
Sbjct: 1292 TWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP 1351

Query: 521  TLTPDSNTTTGLSTSTASPHTRANSTST 548
            +++ D               T+ NST T
Sbjct: 1352 SISKDDPLA---EVGVKEVKTKVNSTLT 1376



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 108/493 (21%), Positives = 168/493 (34%), Gaps = 53/493 (10%)

Query: 31   PAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQ 90
            P+P  + +   + ALL C  S S   L  V W+   K+ + L FR++QG  +  P     
Sbjct: 2486 PSPSNLTLTAHTPALLPCEASGSPKPL--VVWW---KDGQKLDFRLQQGAYRLLPSN--- 2537

Query: 91   RLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPV 150
                      L LT   PQD   F C       + +R+       P  P I  +     V
Sbjct: 2538 ---------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVP--PTIADDQTDFTV 2586

Query: 151  NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKA 210
                P  V TC    G P P V W K G  L    +   +  S  +E      + +    
Sbjct: 2587 TMMAPV-VLTCHS-TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHA---- 2640

Query: 211  QLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEI 270
                     ++ C         +          PV  P   V   V         + V +
Sbjct: 2641 --------GRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAE-------EEVLL 2685

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMIS 330
             C A G P P  +  K+  +            G L +  A  E +G Y C  +  ++  S
Sbjct: 2686 PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC--IAKNSAGS 2743

Query: 331  LLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETG 383
             + + + L+V     +          EGS   L C+A  S +    W ++       E  
Sbjct: 2744 AMGKTR-LVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGK 2802

Query: 384  QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
              ++    L + +L+ +  G Y C A   +  G  R + V++ I   P          ++
Sbjct: 2803 FTIQPSGELLVKNLEGQDAGTYTCTAE--NAVGRARRR-VHLTILVLPVFTTLPGDRSLR 2859

Query: 444  ENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASN 503
                L L C A G P P I W VN     +    Q   STL              C A N
Sbjct: 2860 LGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAEN 2919

Query: 504  DLGKNTSILFLEL 516
             +G+  ++ F+ +
Sbjct: 2920 RVGRTQAVSFVHV 2932



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 118/501 (23%), Positives = 187/501 (37%), Gaps = 106/501 (21%)

Query: 78   QGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPE 137
            +G+    PGE    L+    G  L +TQ   QD  ++ C       +  R        P 
Sbjct: 1106 RGEEPVSPGEDTYLLA---GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVP- 1161

Query: 138  EPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKE------EKNRVHIQ 191
             P+I+   L   +   + +         G+P P++ W+K+GRPL          + V +Q
Sbjct: 1162 -PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQ 1220

Query: 192  SSQT-VESSGLYTLQSILKAQLVKED-KDAQFYCELNYRLPSGNHMKESREVTVPVFYPT 249
              Q  + S+G Y   S + A  V E  K  Q    L   +  G       EVTV V  P 
Sbjct: 1221 VLQANLSSAGHY---SCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNP- 1276

Query: 250  EKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAE--EETTNDNGVLVL 307
                              + + C A   P P+ +  K       +   +     +G+ +L
Sbjct: 1277 ------------------ISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQIL 1318

Query: 308  EPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPE------------- 354
              A+KE +G+Y C          + +E  E + NY  +V + P+  +             
Sbjct: 1319 N-AQKEDAGQYTCV---------VTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368

Query: 355  RQEGSSLTLTCEAESSQDLEFQWLREETG-------QVLERGPVLQLHDLKREAGGGYRC 407
             +  S+LTL CE+ +      +W ++          QVL  G +LQ+   +    G Y C
Sbjct: 1369 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1428

Query: 408  VASVPSIPGLNRTQLVNVAIFGPPWM--------AF----KERKV--------WVKENMV 447
            VA+  ++ G    Q  NV I  PP          AF    +E +          + EN  
Sbjct: 1429 VAT--NVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNP 1485

Query: 448  LNLSCEASGHPRPTISWNVNGTASEQDQ-----DPQRVLSTLNVLVTPELLETGV---EC 499
              L C+ +  P P ++W        +DQ     D   VL    VL  P +         C
Sbjct: 1486 AYLYCDTNAIPPPDLTW------YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSC 1539

Query: 500  TASNDLGKNTSILFLELVNLT 520
             ASN++G++   L  EL+ LT
Sbjct: 1540 KASNEVGEDW--LHYELLVLT 1558



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 56/230 (24%), Positives = 89/230 (38%), Gaps = 25/230 (10%)

Query: 92   LSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVN 151
            +S QD G+TL    V+ +D   ++C  +    +   +     K  E P +Q       V 
Sbjct: 2891 VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK--EAPVLQGEAFSYLVE 2948

Query: 152  SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
                     CV R G P+P + W K+G PL+    R  +Q+               L  +
Sbjct: 2949 PVGGSIQLDCVVR-GDPVPDIHWIKDGLPLRGSHLRHQLQNGS-------------LTIR 2994

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEI 270
              + D   ++ C         N M  +++V + V         +VEP  M ++ GD V +
Sbjct: 2995 RTERDDAGRYQCLAE------NEMGVAKKVVILVLQSAPV--FQVEPQDMTVRSGDDVAL 3046

Query: 271  RCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
            RC A G P P     +     R +    T  +G L LE      +G Y+C
Sbjct: 3047 RCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDC 3096



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 108/449 (24%), Positives = 170/449 (37%), Gaps = 69/449 (15%)

Query: 98   GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
            G +L L  +   D   + C    P  ++ R+       P  P I+    G       P E
Sbjct: 1990 GGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVP--PTIKQGADGSGTLVSRPGE 2047

Query: 158  VAT--CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKE 215
            + T  C  R   PI  V W K+G PL          S +T+     +TL+ I K QL   
Sbjct: 2048 LVTMVCPVRGSPPI-HVSWLKDGLPLP--------LSQRTLLHGSGHTLR-ISKVQLADA 2097

Query: 216  DKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD 275
                 F C      P+G      R  T+ V  P     +E +   ++  G  VE+ C A 
Sbjct: 2098 ---GIFTCVA--ASPAG---VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEAR 2149

Query: 276  GNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LDTM 328
            G P P  S  K   P   ++ E+  +    L LE      SG Y C  +           
Sbjct: 2150 GVPLPLVSWMKDGEPLLSQSLEQGPS----LQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2205

Query: 329  ISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLER 388
            ++++  P        +++ ++P AP       + L C+A+ +      W ++  GQ L R
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAP-------MELLCDAQGTPQPNITWHKD--GQALTR 2256

Query: 389  -------GPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVA----IFGPPWMAFKE 437
                     VL++ D      G Y C+A  P+   + ++  V V     I GP    F  
Sbjct: 2257 LENNSRATRVLRVRD-----AGLYTCLAESPA-GAIEKSFRVRVQAPPNIVGPRGPRFV- 2309

Query: 438  RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQD---QDPQR-VLSTLNVLVTPELL 493
              V +    ++ L C     P P I+W+ +G   ++D   Q P+R     L  L T +  
Sbjct: 2310 --VGLAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD-- 2364

Query: 494  ETGVECTASNDLGKNTSILFLELVNLTTL 522
                 CTA N  G  +    +E+  + T+
Sbjct: 2365 SGDYSCTARNAAGSTSVAFRVEIHTVPTI 2393



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 90/394 (22%), Positives = 146/394 (37%), Gaps = 56/394 (14%)

Query: 98  GATLALTQVTPQDERIFLCQGKRP-RSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPE 156
           G  L L +    D  ++ C+      + E   +L VY  P        P  +   +  P 
Sbjct: 273 GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPV 332

Query: 157 EVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKED 216
            +  CV R G+P P + W+  G P+ E               S L T  S+L+ +   E 
Sbjct: 333 ALE-CVAR-GHPSPTLSWHHEGLPVAESNE------------SRLETDGSVLRLESPGEA 378

Query: 217 KDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLEVEPVGMLKE--GDRVEIRCL 273
               + C  +   P+G  + + S EV VP         L  E +G +    G  +E+ C 
Sbjct: 379 SSGLYSCVASS--PAGEAVLQYSVEVQVP------PQLLVAEGLGQVTTIVGQPLELPCQ 430

Query: 274 ADGNPPPHFS-ISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD------LD 326
           A G+P P    +    P+   A  +  +    L ++    +HSG + CQ  +       +
Sbjct: 431 ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490

Query: 327 TMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCE--------AESSQDLEFQWL 378
             +S+  E        V +V +       +  SS    C+        A     L   W 
Sbjct: 491 VEVSVHGE----WAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWC 546

Query: 379 R------EETGQVLERG--PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
                  E TG  +     P LQ+  +     G Y C A+  ++ G ++ + V + +  P
Sbjct: 547 SPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAAT--NLAGESKRE-VALKVLVP 603

Query: 431 PWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
           P +        V EN  + L C ASG P P +SW
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSW 637



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 90/427 (21%), Positives = 157/427 (36%), Gaps = 37/427 (8%)

Query: 94  LQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSK 153
           L D G +L   ++   D  ++ C+ +       R    +   P  P++        V   
Sbjct: 82  LLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTP--PSVLGAGAAQEVLGL 139

Query: 154 EPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSS-QTVESSGLYTLQSILKAQL 212
              +V      +G P PQV W K+ +P+      + +Q   Q +  +G +          
Sbjct: 140 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV--------- 190

Query: 213 VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEIR 271
                + ++ C      P+G   +++R+  + V  P   +W   E   + + E   V++ 
Sbjct: 191 ---GDEGRYQCVAFS--PAG---QQARDFQLRVHAPPT-IWGSNETGEVAVMEDHLVQLL 241

Query: 272 CLADGNPPPHFSISKQNPSTREAEEETTNDNG-VLVLEPARKEHSGRYECQGLDLDTMIS 330
           C A G P P+ +  K       + +      G  L L  A+   +G Y C+  +      
Sbjct: 242 CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE 301

Query: 331 LLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLRE-------ETG 383
             +     +   +      P   +   G  + L C A         W  E          
Sbjct: 302 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNES 361

Query: 384 QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKER--KVW 441
           ++   G VL+L      + G Y CVAS P+   + +    +V +  PP +   E   +V 
Sbjct: 362 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ---YSVEVQVPPQLLVAEGLGQVT 418

Query: 442 VKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVT-PELLETGV-EC 499
                 L L C+ASG P PTI W  NG  +E+    Q       + +   EL  +G+  C
Sbjct: 419 TIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFAC 478

Query: 500 TASNDLG 506
            A+N+ G
Sbjct: 479 QATNEAG 485



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 69/312 (22%), Positives = 115/312 (36%), Gaps = 37/312 (11%)

Query: 166  GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCEL 225
            G P+P + W +NG P         ++  Q            +L+    +    A + C  
Sbjct: 1589 GNPVPTISWLQNGLPFSPSPRLQVLEDGQ------------VLQVSTAEVADAASYMCVA 1636

Query: 226  NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSIS 285
              +  S   +      T+ V  P     L++E V  +     V + C    +P P  +  
Sbjct: 1637 ENQAGSAEKL-----FTLRVQVPPRIAGLDLEQVTAILNSS-VSLPCDVHAHPNPEVTWY 1690

Query: 286  KQNPSTREAEEE-TTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS 344
            K + +    EE         L L  AR   SG Y C+ L+       L    +L V    
Sbjct: 1691 KDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL---VQLSVLVPP 1747

Query: 345  DVRVSPAAPER----QEGSSLTLTCEAESSQDLEFQWLRE-------ETGQVLERGPVLQ 393
              R +P  P+     + G    L+CE ++  +    W ++       +  Q L  G  L+
Sbjct: 1748 AFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLE 1807

Query: 394  LHDLKREAGGGYRCVASVPSIPG-LNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSC 452
            + + +    G Y C   V ++ G   RT  + V +  P +   K   V       L L+C
Sbjct: 1808 IQEAQVSDKGLYSC--KVSNVAGEAVRTFTLTVQV-PPTFENPKTETVSQVAGSPLVLTC 1864

Query: 453  EASGHPRPTISW 464
            + SG P PT++W
Sbjct: 1865 DVSGVPAPTVTW 1876



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 94/447 (21%), Positives = 164/447 (36%), Gaps = 59/447 (13%)

Query: 84   EPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ-EYRIQLRVYKAPEEPNIQ 142
            +P   E  L LQ++G +L + +        + C  +    + E + +L V   PE     
Sbjct: 1015 QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIG-D 1073

Query: 143  VNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLY 202
            ++PL     +        C    G P P + W++   P+               E + L 
Sbjct: 1074 LDPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGEEPVSPG------------EDTYLL 1120

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
                +LK    +E     + C     L S    +  R  +V V  P      ++E V  +
Sbjct: 1121 AGGWMLKMTQTQEQDSGLYSC-----LASNEAGEARRNFSVEVLVPPSIENEDLEEVIKV 1175

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLV-LEPARKEHSGRYECQ 321
             +G    + C   G+P P  +  K        +    + +GVL+ +  A    +G Y C 
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235

Query: 322  GLDL------DTMISLLSEPQELL-VNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLE 374
              +          +S+L  P  L      +D  V+         + ++L CEA +     
Sbjct: 1236 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV-----NNPISLICEALAFPSPN 1290

Query: 375  FQWLREETG-------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
              W+++          Q+L     LQ+ + ++E  G Y CV +      +      +V +
Sbjct: 1291 ITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKN---YHVEV 1347

Query: 428  FGPPWMAFKE-------RKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV 480
              PP ++  +       ++V  K N  L L CE+   P PTI W        +D  P   
Sbjct: 1348 LIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRW-------YKDGQPVTP 1400

Query: 481  LSTLNVLVTPELLETGVECTASNDLGK 507
             S L VL    LL+  ++ T  +D G+
Sbjct: 1401 SSRLQVLGEGRLLQ--IQPTQVSDSGR 1425



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 86/400 (21%), Positives = 133/400 (33%), Gaps = 73/400 (18%)

Query: 96   DRGATLALTQVTPQDERIFLCQGKRPR---SQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
            +RG  L L  ++  D   + C  +      S  +R+++        P I+  P  + V+ 
Sbjct: 2350 ERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV-----PTIRSGPPAVNVSV 2404

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL 212
             +   +  C   +G P P V W K+  PL     R  I              +  L+ Q 
Sbjct: 2405 NQTA-LLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILP------------EGSLRIQP 2450

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPT-EKVWLEVEPVGMLKEGDRVEIR 271
            V       + C  +    S    ++ R +  P   P+   + L      +L         
Sbjct: 2451 VLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP-------- 2502

Query: 272  CLADGNPPPHFSISKQNPST----REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDT 327
            C A G+P P     K         ++        N +L+  P  ++ S ++EC       
Sbjct: 2503 CEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD-SAQFEC------V 2555

Query: 328  MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLT------LTCEAESSQDLEFQW---- 377
            + + + E   L   Y   V V P   + Q   ++T      LTC +         W    
Sbjct: 2556 VSNEVGEAHRL---YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG 2612

Query: 378  ---------LREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                      R      LE G  L +H       G Y C  S  +  G+    +      
Sbjct: 2613 AQLGARGSGYRVSPSGALEIGQALPIH------AGRYTC--SARNSAGVAHKHVFLTVQA 2664

Query: 429  GPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             P           V E  VL L CEASG PRPTI+W   G
Sbjct: 2665 SPVVKPLPSVVRAVAEEEVL-LPCEASGIPRPTITWQKEG 2703


>gi|10835203 advanced glycosylation end product-specific receptor
           isoform 1 precursor [Homo sapiens]
          Length = 404

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 64/229 (27%), Positives = 98/229 (42%), Gaps = 18/229 (7%)

Query: 100 TLALTQVTPQDERIFLCQGKRPRSQEYR--IQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
           +L L  V  QDE IF CQ      +E +   ++RVY+ P +P I  +     + +  P +
Sbjct: 83  SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS--ASELTAGVPNK 140

Query: 158 VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHI-QSSQTVESSGLYTLQSILKAQLVK-E 215
           V TCV    YP   + W+ +G+PL   +  V + + ++    +GL+TLQS L     +  
Sbjct: 141 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 200

Query: 216 DKDAQFYCELNYRLPSGNHMKES---REVTVPVFYPTEKVWLEVEPV-GMLKEGDRVEIR 271
           D    F C  +  LP    ++ +     V  PV  P E+V L VEP  G +  G  V + 
Sbjct: 201 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV--PLEEVQLVVEPEGGAVAPGGTVTLT 258

Query: 272 CLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYEC 320
           C     P P     K      +        + VL+L     +  G Y C
Sbjct: 259 CEVPAQPSPQIHWMK------DGVPLPLPPSPVLILPEIGPQDQGTYSC 301



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 1/83 (1%)

Query: 348 VSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRC 407
           V P       G ++TLTCE  +    +  W+++     L   PVL L ++  +  G Y C
Sbjct: 242 VEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSC 301

Query: 408 VASVPSIPGLNRTQLVNVAIFGP 430
           VA+  S  G   ++ V+++I  P
Sbjct: 302 VAT-HSSHGPQESRAVSISIIEP 323


>gi|13489095 sialoadhesin precursor [Homo sapiens]
          Length = 1709

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 86/335 (25%), Positives = 142/335 (42%), Gaps = 31/335 (9%)

Query: 192 SSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEK 251
           +SQ  E +G+  L+++  A +  +D      C+L+      NH  +S E+ + V Y  + 
Sbjct: 187 NSQKFEPTGVGHLETLHMA-MSWQDHGRILRCQLSV----ANHRAQS-EIHLQVKYAPKG 240

Query: 252 VWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPA 310
           V + + P G  +  G+ V + C  + + P   SI       R          GVL L  A
Sbjct: 241 VKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGVR-----LQTKTGVLHLPQA 295

Query: 311 RKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEA--E 368
               +G Y CQ  +   + SL+S P  L + ++++V+VSPA P   E  ++TL C    E
Sbjct: 296 AWSDAGVYTCQAEN--GVGSLVSPPISLHI-FMAEVQVSPAGPIL-ENQTVTLVCNTPNE 351

Query: 369 SSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
           +  DL + W +            L+LH   R   G Y C   V ++ G  R+  V+V + 
Sbjct: 352 APSDLRYSWYKNHVLLEDAHSHTLRLHLATRADTGFYFC--EVQNVHGSERSGPVSVVVN 409

Query: 429 GPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG-----TASEQDQDPQRVLST 483
            PP        +  +  +V  L C     P  T+  +  G     T+ + D  P+   ++
Sbjct: 410 HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTS 469

Query: 484 ------LNVLVTPELLETGVECTASNDLGKNTSIL 512
                 L +    E      +C+A+N LG  TS L
Sbjct: 470 GPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTL 504



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 101/452 (22%), Positives = 156/452 (34%), Gaps = 88/452 (19%)

Query: 101  LALTQVTPQDERIFLCQGKRPRSQ-----EYRIQ-LRVYKAPEEPNIQVNPLGIPVNSKE 154
            L L    P+DE  + C  + P  Q     E R++ +RV  APE       P G P+    
Sbjct: 1226 LELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEA----AVPEGAPIT--- 1278

Query: 155  PEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
                 TC     +      WY NGR L+E           T   +G Y+ Q+        
Sbjct: 1279 ----VTCADPAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQA-------- 1326

Query: 215  EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
              +DAQ               + SR   + V Y  +   L        +      I+C  
Sbjct: 1327 --QDAQ-------------GTRSSRPAALQVLYAPQDAVLSSFRDSRARS--MAVIQCTV 1369

Query: 275  DGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKE----------HSGRYECQGLD 324
            D  PP   ++S        +    +  +G   ++ AR                Y C   +
Sbjct: 1370 DSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQN 1429

Query: 325  LDTMISLLSEPQELLVNYVSDVRV-SPAAPERQEGSSLTLTCEAESSQ----DLEFQWLR 379
            L   IS +   Q      V   RV +    +  EG++L L+C          +  F W  
Sbjct: 1430 LLGSISTIGRLQ------VEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFW 1483

Query: 380  EETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPP----WMAF 435
             +     E  P L    + R   G Y C+A +P+  G   +  V + +  PP     M F
Sbjct: 1484 NDRRLHAEPVPTLAFTHVARAQAGMYHCLAELPT--GAAASAPVMLRVLYPPKTPTMMVF 1541

Query: 436  KERKVWVKENMVLNLSCEASGHPRPTISWNVNG--TASEQDQDPQRVLSTLNVLVTPELL 493
             E +  ++      L C     P  +++ ++     AS Q Q        ++VL +P  L
Sbjct: 1542 VEPEGGLRG----ILDCRVDSEPLASLTLHLGSRLVASSQPQGAP-AEPHIHVLASPNAL 1596

Query: 494  ETGVE-----------CTASNDLGK-NTSILF 513
               +E           C+ASN LG  +TS  F
Sbjct: 1597 RVDIEALRPSDQGEYICSASNVLGSASTSTYF 1628



 Score = 36.2 bits (82), Expect = 0.096
 Identities = 88/396 (22%), Positives = 144/396 (36%), Gaps = 74/396 (18%)

Query: 100 TLALTQVTPQDERIFLCQ----GKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEP 155
           TL +        RI  CQ      R +S+   I L+V  AP+   I ++P G  +   E 
Sbjct: 201 TLHMAMSWQDHGRILRCQLSVANHRAQSE---IHLQVKYAPKGVKILLSPSGRNILPGEL 257

Query: 156 EEVATCVGRNGYP-IPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVK 214
             + TC   + YP +  + W K+G  L+ +   +H+  +     +G+YT Q+        
Sbjct: 258 VTL-TCQVNSSYPAVSSIKWLKDGVRLQTKTGVLHLPQA-AWSDAGVYTCQA-------- 307

Query: 215 EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
                           +G     S  +++ +F       ++V P G + E   V + C  
Sbjct: 308 ---------------ENGVGSLVSPPISLHIFMAE----VQVSPAGPILENQTVTLVCNT 348

Query: 275 DGNPPP--HFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLL 332
               P    +S  K +    +A   T      L L  A +  +G Y C+  ++    S  
Sbjct: 349 PNEAPSDLRYSWYKNHVLLEDAHSHT------LRLHLATRADTGFYFCEVQNVHG--SER 400

Query: 333 SEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL------ 386
           S P  ++VN+     V  A  E Q G    L C   S        +    G +L      
Sbjct: 401 SGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSEPLATL--VLSHGGHILASTSGD 458

Query: 387 ---------ERGP---VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMA 434
                      GP    L++ DL+    G Y+C A+  S+   N T  ++        + 
Sbjct: 459 SDHSPRFSGTSGPNSLRLEIRDLEETDSGEYKCSAT-NSLG--NATSTLDFHANAARLLI 515

Query: 435 FKERKVWVKENMVLNLSCEASGHPRP--TISWNVNG 468
               +  V E   + LSC +   P P    SW +NG
Sbjct: 516 SPAAE--VVEGQAVTLSCRSGLSPTPDARFSWYLNG 549



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 77/354 (21%), Positives = 116/354 (32%), Gaps = 75/354 (21%)

Query: 94  LQDRGATLALTQVTPQDERIFLCQGKRPRSQEYR--IQLRVYKAPEEPNIQVNPLGIPVN 151
           LQ +   L L Q    D  ++ CQ +          I L ++ A     +QV+P G P+ 
Sbjct: 283 LQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMA----EVQVSPAG-PIL 337

Query: 152 SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
             +   +            +  WYKN   L++  +                     L+  
Sbjct: 338 ENQTVTLVCNTPNEAPSDLRYSWYKNHVLLEDAHSHT-------------------LRLH 378

Query: 212 LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEV--------------E 257
           L        ++CE+     S      S  V  P   P    +LE               E
Sbjct: 379 LATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPLTPVLTAFLETQAGLVGILHCSVVSE 438

Query: 258 PVG--MLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHS 315
           P+   +L  G  +      D +  P FS +    S R            L +    +  S
Sbjct: 439 PLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLR------------LEIRDLEETDS 486

Query: 316 GRYECQGLDLDTMISLLSEPQELLVNYVSDVR--VSPAAPERQEGSSLTLTCEA--ESSQ 371
           G Y+C   +       L      L  + +  R  +SPAA E  EG ++TL+C +    + 
Sbjct: 487 GEYKCSATNS------LGNATSTLDFHANAARLLISPAA-EVVEGQAVTLSCRSGLSPTP 539

Query: 372 DLEFQWLREETGQVLERGP--VLQLHDLKREAGGGYRC------VASVPSIPGL 417
           D  F W     G +L  GP   L L        G Y C       AS PS P +
Sbjct: 540 DARFSWYL--NGALLHEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAV 591



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 58/268 (21%), Positives = 93/268 (34%), Gaps = 43/268 (16%)

Query: 231  SGNHMKESREV----TVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISK 286
            SG++  E+  V       +F+     W++V P   L+EG  V + C      P   S   
Sbjct: 871  SGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQEGQAVVLSCQVHTGVPEGTSYRW 930

Query: 287  QNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDV 346
                 R+ +    + +  L         +G Y CQ     +  + L+ P  L V+Y    
Sbjct: 931  Y----RDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRH 986

Query: 347  RVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREE--TGQVLE--RGPV----------- 391
                   +   G    L C  +S    + + L  +      L+   GP            
Sbjct: 987  VTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVA 1046

Query: 392  -----LQLHDLKREAGGGYRCVAS----VPSIPGLNRTQLVNVAIFGPPWMAFKERKVWV 442
                 L++H    E  G Y C AS      S       Q VNV +    W         V
Sbjct: 1047 PNTLRLEIHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQV----WPG-----ATV 1097

Query: 443  KENMVLNLSCEA-SGHP-RPTISWNVNG 468
            +E  ++NL+C   + HP + T +W  +G
Sbjct: 1098 REGQLVNLTCLVWTTHPAQLTYTWYQDG 1125


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
           precursor [Homo sapiens]
          Length = 2012

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/288 (24%), Positives = 118/288 (40%), Gaps = 35/288 (12%)

Query: 265 GDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLD 324
           G RVE+ C A G+P P +   K N     +        G+L+ E  R   SG Y C+  +
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLI-ENIRPSDSGSYVCEVSN 297

Query: 325 LDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQ 384
                 ++     L V       +SP   +   GS ++L+C    ++D E  W R   G+
Sbjct: 298 RYGTAKVIGR---LYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYR--NGE 352

Query: 385 VLERGPVLQLHDLKRE----------AGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMA 434
           +L  G  +++  +  E           GG Y+C      +   +  Q+V          A
Sbjct: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA 412

Query: 435 FKERKVWVKENMVLNLSCEASGHPRPTISWNVNG---------TASEQDQDPQRVLSTLN 485
           F E+ V   E   ++L C   G P PTI+W ++            S+       V+S LN
Sbjct: 413 FSEKVVSPAE--PVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLN 470

Query: 486 VLVTPELLETGV-ECTASNDLGKNTSILFLELVNL---TTLTPDSNTT 529
           +  + ++ + GV  CTA+N  G    +L+   +N+    ++ P  N T
Sbjct: 471 I-SSSQVRDGGVYRCTANNSAG---VVLYQARINVRGPASIRPMKNIT 514



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 77/401 (19%), Positives = 136/401 (33%), Gaps = 59/401 (14%)

Query: 149 PVNSKEPEEVATCVGRN--------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSG 200
           P + +  + +    GR+        GYP   + WYKN   L     +V  +++ T++ S 
Sbjct: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLS- 562

Query: 201 LYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVG 260
                      + KE  + ++ C +  +      +  S+ V V V  P    +++     
Sbjct: 563 ----------DVQKEVDEGEYTCNVLVQ----PQLSTSQSVHVTVKVPP---FIQPFEFP 605

Query: 261 MLKEGDRVEIRC-LADGNPPPHFSISKQN---PSTREAEEETTNDNGVLVLEPARKEHSG 316
               G RV I C +  G+ P   +  K     P +     +  +    L +      H+G
Sbjct: 606 RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665

Query: 317 RYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
            Y C   +     + +    +L+V       V P   +   G ++ L C AE        
Sbjct: 666 NYTCIARN---EAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIV 722

Query: 377 WLREETG--------------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQL 422
           W   +                QVL  G +L  H +  E  G Y C  S      ++++  
Sbjct: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH-VVEEDSGYYLCKVSNDVGADVSKSMY 781

Query: 423 VNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQD-------- 474
           + V I  P  +          +     +SC A G     + W         +        
Sbjct: 782 LTVKI--PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST 839

Query: 475 -QDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFL 514
            +  + V+STL +L T         C A N  G++  I+ L
Sbjct: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQL 880



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 59/250 (23%), Positives = 94/250 (37%), Gaps = 28/250 (11%)

Query: 301 DNGVLVLEPARKE-HSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAA-PERQEG 358
           +NG L L   +KE   G Y C  L    +   LS  Q + V       + P   P    G
Sbjct: 555 NNGTLKLSDVQKEVDEGEYTCNVL----VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIG 610

Query: 359 SSLTLTCEAESSQ-DLEFQWLREE---------TGQVLERGPVLQLHDLKREAGGGYRCV 408
             + + C   S    +   W ++          T   ++    L++ +L     G Y C+
Sbjct: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCI 670

Query: 409 ASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
           A   +    +++QL+   +  PP    + R         + L+C A G+P PTI W  + 
Sbjct: 671 ARNEAAAVEHQSQLI---VRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSK 727

Query: 469 TASEQDQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTS-ILFLELVNL 519
            A      P  +   + VL    LL   V         C  SND+G + S  ++L +   
Sbjct: 728 GAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 787

Query: 520 TTLTPDSNTT 529
             +T   NTT
Sbjct: 788 AMITSYPNTT 797



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 29/103 (28%), Positives = 52/103 (50%), Gaps = 12/103 (11%)

Query: 441  WVKENMVLNLSCEASGHPRPTISW--NVNGTASEQDQDPQRVLSTLN--VLVTPELLETG 496
            W+K+   + L C+A G P P + W  + NGT S    D +R + +    ++ T +  ++G
Sbjct: 1299 WMKD---IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSG 1355

Query: 497  -VECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTAS 538
               C A+N+ G +  IL L++     + PD    T   T+++S
Sbjct: 1356 YYSCIANNNWGSDEIILNLQV----QVPPDQPRLTVSKTTSSS 1394



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 32/142 (22%), Positives = 52/142 (36%), Gaps = 21/142 (14%)

Query: 268  VEIRCLADGNPPPHFSISKQNPSTREAE----EETTNDNGVLVLEPARKEHSGRYECQGL 323
            + + C A G+P P     K +  T          +   NG  ++   + E SG Y C   
Sbjct: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC--- 1359

Query: 324  DLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG 383
                + +      E+++N    V+V P  P         LT    +S  +   WL  + G
Sbjct: 1360 ----IANNNWGSDEIILNL--QVQVPPDQPR--------LTVSKTTSSSITLSWLPGDNG 1405

Query: 384  QVLERGPVLQLHDLKREAGGGY 405
                RG +LQ  +   E  G +
Sbjct: 1406 GSSIRGYILQYSEDNSEQWGSF 1427


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 75/336 (22%), Positives = 127/336 (37%), Gaps = 45/336 (13%)

Query: 89  EQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ--EYRIQLRVYKAPEEPNIQVNPL 146
           + RL+L D G TL +      D+ I+ C  K    +     + LR + +P  P   + P 
Sbjct: 291 DSRLNLLDDG-TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQ 349

Query: 147 GIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQS 206
              V     E V       G+P P++ W +  R       RV+I       S GLY    
Sbjct: 350 NTEV--LVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNI-----TPSGGLYI--- 399

Query: 207 ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
               Q V +    ++ C     + S +         +P F  T +  + +E       G 
Sbjct: 400 ----QNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIE-------GQ 448

Query: 267 RVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLD 326
            V+ +C A GNPPP  + +K               +G L +        G+YECQ ++  
Sbjct: 449 TVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVN-- 506

Query: 327 TMISLLSEPQELLVNYVSDVRVS------PAAPERQEGSSLTLTCEAESSQDLEFQWLRE 380
                +   Q+++ +     RV+      P+    + G+++ L C ++   +    W ++
Sbjct: 507 -----IIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKD 561

Query: 381 ETGQVLERGP-------VLQLHDLKREAGGGYRCVA 409
              QV E G         L ++D+     G Y CVA
Sbjct: 562 GV-QVTESGKFHISPEGFLTINDVGPADAGRYECVA 596



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 76/349 (21%), Positives = 133/349 (38%), Gaps = 30/349 (8%)

Query: 183 EEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVT 242
           E   R+ + S+       +  L  +LK      +  A   CE   R+        S    
Sbjct: 182 ESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQG-----RSVATI 236

Query: 243 VPVFYPTEKVWLEVEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN- 300
            P     E+  +  EP    +  G+ V   C A+GNP P     + N       +   N 
Sbjct: 237 TPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL 296

Query: 301 -DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVR-----VSPAAPE 354
            D+G L+++  ++   G Y+C   ++   +    + QE+ + Y          + P   E
Sbjct: 297 LDDGTLMIQNTQETDQGIYQCMAKNVAGEV----KTQEVTLRYFGSPARPTFVIQPQNTE 352

Query: 355 RQEGSSLTLTCEAESSQDLEFQWLREETGQV-------LERGPVLQLHDLKREAGGGYRC 407
              G S+TL C A         W R +   +       +     L + ++ +   G Y C
Sbjct: 353 VLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYAC 412

Query: 408 VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVN 467
            A+  +I  ++ T  + V    P +    + +V V E   ++  CEA G+P P I+W   
Sbjct: 413 SAT-NNIDSVHATAFIIVQAL-PQFTVTPQDRV-VIEGQTVDFQCEAKGNPPPVIAWTKG 469

Query: 468 GTASEQDQDPQRVLSTLNVLVTPELL--ETGVECTASNDLGKNTSILFL 514
           G+    D+    VLS+  + ++   L  +   EC A N +G    +  L
Sbjct: 470 GSQLSVDR-RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHL 517



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 95/435 (21%), Positives = 164/435 (37%), Gaps = 39/435 (8%)

Query: 137 EEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLK-EEKNRVHIQSSQT 195
           E P I   P    V S       TC    G P P++IW +N   L  +  +R+++    T
Sbjct: 244 ERPRITSEPQDADVTSGNTVYF-TCRAE-GNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301

Query: 196 VESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLE 255
                       L  Q  +E     + C    +  +G    +++EVT+  F    +    
Sbjct: 302 ------------LMIQNTQETDQGIYQCMA--KNVAGE--VKTQEVTLRYFGSPARPTFV 345

Query: 256 VEPVGM-LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETT-NDNGVLVLEPARKE 313
           ++P    +  G+ V + C A G+PPP  S ++ + +    +       +G L ++   + 
Sbjct: 346 IQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405

Query: 314 HSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDL 373
            SG Y C   +    I  +     ++V  +    V+P      EG ++   CEA+ +   
Sbjct: 406 DSGEYACSATN---NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462

Query: 374 EFQWLREETGQVLERGPVLQLHDLKREAG------GGYRCVASVPSIPGLNRTQLVNVAI 427
              W +  +   ++R  ++      R +G      G Y C A V  I        + V  
Sbjct: 463 VIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQA-VNIIGSQKVVAHLTVQP 521

Query: 428 FGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG---TASEQDQDPQRVLSTL 484
              P  A       V+    + L C + G P P I+WN +G   T S +         T+
Sbjct: 522 RVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTI 581

Query: 485 NVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLT--PDSNTTTGLSTSTASPHTR 542
           N +   +      EC A N +G + S+  +  VN+  ++   D    T +  + A+    
Sbjct: 582 NDVGPAD--AGRYECVARNTIG-SASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRA 638

Query: 543 ANSTSTERKLPEPES 557
            NST T      P S
Sbjct: 639 INSTRTHLFDSRPRS 653


>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
          Length = 388

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 75/311 (24%), Positives = 131/311 (42%), Gaps = 42/311 (13%)

Query: 22  AGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQG 81
           A  PG  ++   E V V  G  A + C L Q  G++  +     +  ++TL F   +   
Sbjct: 18  AAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQ----NPARQTLFFNGTRALK 73

Query: 82  QSEPGEYEQRLSLQD---RGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEE 138
                  ++R  L++   R   + L+    +DE  + CQ     +      L V  APE 
Sbjct: 74  -------DERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPEN 126

Query: 139 PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES 198
           P ++V    +     E     +C+     P   + WY++ + LK       + SSQ  E+
Sbjct: 127 PVVEVREQAVEGGEVE----LSCLVPRSRPAATLRWYRDRKELKG------VSSSQ--EN 174

Query: 199 SGLYTLQSILKAQLVKEDKDAQFYCEL-NYRLPSGNHMKESREVTVPVFYPTEKVWLEVE 257
             ++++ S ++ ++ ++D      CE  N  LPSG H K+++ V    + PT ++     
Sbjct: 175 GKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSG-HSKQTQYVLDVQYSPTARIHASQ- 232

Query: 258 PVGMLKEGDRVEIRCLADGNPPPH-FSISKQN---PSTREAEEET-------TNDNGVLV 306
              +++EGD + + C   GNP P+    ++ N   P   EA  ET       + DNG   
Sbjct: 233 --AVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYT 290

Query: 307 LEPARKEHSGR 317
            E + K    R
Sbjct: 291 CEASNKHGHAR 301



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 59/231 (25%), Positives = 91/231 (39%), Gaps = 38/231 (16%)

Query: 307 LEPARKEHSGRYECQGLDLDT-----MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSL 361
           L  AR E  G Y CQ    DT      +++L  P+    N V +VR      +  EG  +
Sbjct: 91  LSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPE----NPVVEVR-----EQAVEGGEV 141

Query: 362 TLTCEAESSQDLE-FQWLRE-----------ETGQVLERGPVLQLHDLKREAGGGYRCVA 409
            L+C    S+     +W R+           E G+V      ++    +++ GG   C A
Sbjct: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEA 201

Query: 410 SVPSIPG--LNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPT-ISWNV 466
              ++P     +TQ V    + P       + V V+E   L L+C  +G+PRP  I WN 
Sbjct: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNPRPNQIRWN- 259

Query: 467 NGTASEQDQDPQRVLSTLNVLVTPELLETG---VECTASNDLGKNTSILFL 514
                  +  P+R  +    L  P L+        C ASN  G   ++  L
Sbjct: 260 ----RGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVL 306


>gi|26787962 advanced glycosylation end product-specific receptor
           isoform 2 precursor [Homo sapiens]
          Length = 342

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 57/189 (30%), Positives = 87/189 (46%), Gaps = 12/189 (6%)

Query: 100 TLALTQVTPQDERIFLCQGKRPRSQEYR--IQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
           +L L  V  QDE IF CQ      +E +   ++RVY+ P +P I  +     + +  P +
Sbjct: 69  SLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDS--ASELTAGVPNK 126

Query: 158 VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHI-QSSQTVESSGLYTLQSILKAQLVK-E 215
           V TCV    YP   + W+ +G+PL   +  V + + ++    +GL+TLQS L     +  
Sbjct: 127 VGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGG 186

Query: 216 DKDAQFYCELNYRLPSGNHMKES---REVTVPVFYPTEKVWLEVEPV-GMLKEGDRVEIR 271
           D    F C  +  LP    ++ +     V  PV  P E+V L VEP  G +  G  V + 
Sbjct: 187 DPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPV--PLEEVQLVVEPEGGAVAPGGTVTLT 244

Query: 272 CLADGNPPP 280
           C     P P
Sbjct: 245 CEVPAQPSP 253


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 107/485 (22%), Positives = 183/485 (37%), Gaps = 85/485 (17%)

Query: 89   EQRLSLQDRGATLALTQVTPQDERIFLCQ-----GKRPRSQEYRIQLRVYK---APEEPN 140
            E R    +  ATL   +V   D   + C+     G       +RIQ R      A +  +
Sbjct: 6124 EYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKD 6183

Query: 141  IQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSG 200
            I+   +G+PV         TC      PI QV WY++G  L++++N   +Q+S     + 
Sbjct: 6184 IE-QTVGLPVT-------LTCRLNGSAPI-QVCWYRDGVLLRDDEN---LQTSFVDNVAT 6231

Query: 201  LYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVG 260
            L  LQ+ L           Q+ C  +  L +      S    +    P +  + +++PV 
Sbjct: 6232 LKILQTDLS-------HSGQYSCSASNPLGTA-----SSSARLTAREPKKSPFFDIKPVS 6279

Query: 261  M-LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGV---LVLEPARKEHSG 316
            + +  G+  +  C   G  P   + SK N   R     T    G    L +    K  SG
Sbjct: 6280 IDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSG 6339

Query: 317  RYECQ-----GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQ 371
            +Y CQ     G D+ +    + EP +    +V  +  S  A   ++G S+ L C+   S 
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKEPPK----FVKKLEASKVA---KQGESIQLECKISGSP 6392

Query: 372  DLEFQWLREETG---------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQL 422
            +++  W R ++            +    +L +++   E  G Y C A          T L
Sbjct: 6393 EIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTAL 6452

Query: 423  VNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLS 482
                +  PP    K   V   +   + L CE SG P   + W          +D ++V +
Sbjct: 6453 ---TVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVW---------VKDRKQVRN 6500

Query: 483  TLNVLVTPELLETGV-------------ECTASNDLGKNT---SILFLELVNLTTLTPDS 526
            +    +T +  +T +              C A+N++G +T   S+ F E         D+
Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDT 6560

Query: 527  NTTTG 531
            +T  G
Sbjct: 6561 STLIG 6565



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 103/502 (20%), Positives = 189/502 (37%), Gaps = 69/502 (13%)

Query: 34   ELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLS 93
            E VE  +G  A L+C +  +      + W+  H + R            S P     ++ 
Sbjct: 7027 EHVEAVIGEPATLQCKVDGTPE--IRISWYKEHTKLR------------SAPA---YKMQ 7069

Query: 94   LQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSK 153
             ++  A+L + +V   D   + C+            + V KA + P      L   V+  
Sbjct: 7070 FKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLK-DVHET 7128

Query: 154  EPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLV 213
                VA     NG    QV WYK+G  LK++ N   +Q+S     + L  LQ+       
Sbjct: 7129 LGFPVAFECRINGSEPLQVSWYKDGVLLKDDAN---LQTSFVHNVATLQILQT------- 7178

Query: 214  KEDKDAQFYCELNYRLPSGNHMKE--SREVTVPVFYPTEKVWLEVEPVGM-LKEGDRVEI 270
             +    Q+ C  +  L + +   +    E  VP F+       +++PV + L  G+    
Sbjct: 7179 DQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFF-------DLKPVSVDLALGESGTF 7231

Query: 271  RCLADGNPPPHFSISKQNPSTREA---EEETTNDNGVLVLEPARKEHSGRYEC-----QG 322
            +C   G  P   + +K N   R     +     +   L +    K  +G+Y C      G
Sbjct: 7232 KCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAG 7291

Query: 323  LDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREET 382
             D  +    + EP   +       ++ P+   +Q+       C+   S +++  W ++ET
Sbjct: 7292 KDSCSAQLGVQEPPRFI------KKLEPSRIVKQD-EFTRYECKIGGSPEIKVLWYKDET 7344

Query: 383  G---------QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM 433
                        ++   VL++H+L  E  G Y C A   +    + T L    +  PP  
Sbjct: 7345 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSL---KVKEPPIF 7401

Query: 434  AFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQD----PQRVLSTLNVLVT 489
              K   +   +   ++L CE  G P   +SW  +       +      +  L+++++L  
Sbjct: 7402 RKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNV 7461

Query: 490  PELLETGVECTASNDLGKNTSI 511
                    +C A+ND+G +T +
Sbjct: 7462 DAADIGEYQCKATNDVGSDTCV 7483



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 100/461 (21%), Positives = 165/461 (35%), Gaps = 79/461 (17%)

Query: 34   ELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLS 93
            E V+V VG +A L+C L+ +      V W+              +G  +  P     ++ 
Sbjct: 7968 EPVKVSVGDSASLQCQLAGTPE--IGVSWY--------------KGDTKLRPTT-TYKMH 8010

Query: 94   LQDRGATLALTQVTPQDERIFLCQGKRPR---SQEYRIQLRVYKAPEEPNIQVNPL---- 146
             ++  ATL   QV   D   ++C+ +      S    + ++  K P   + Q+  +    
Sbjct: 8011 FRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV 8070

Query: 147  GIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQS 206
            G+PV       V  C      PI  V WYK+G+PLK+  N   +Q+S          L +
Sbjct: 8071 GLPV-------VFDCAISGSEPI-SVSWYKDGKPLKDSPN---VQTS---------FLDN 8110

Query: 207  ILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTV----PVFYPTEKVWLEVEPVGML 262
                 + K D+            P G+    +R +      P F+      + + PV  +
Sbjct: 8111 TATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFD-----IRLAPVDAV 8165

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREA---EEETTNDNGVLVLEPARKEHSGRYE 319
              G+  +  C   G  P   S +K +   R     +     ++  L +    K  SG+Y 
Sbjct: 8166 -VGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYT 8224

Query: 320  CQGLD---LDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
            C  ++    D+  + L+  + L+    +  R+S    E  EG+S  L      SQ +   
Sbjct: 8225 CYAVNEVGKDSCTAQLNIKERLIPPSFTK-RLSETV-EETEGNSFKLEGRVAGSQPITVA 8282

Query: 377  WLREETGQVLERGP-------------VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLV 423
            W +      +E  P             VLQ+        G Y C  S  +   L  + +V
Sbjct: 8283 WYKNN----IEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIV 8338

Query: 424  NVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
                  PP        V V E   + LSC   G     I W
Sbjct: 8339 IKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQW 8379



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 104/531 (19%), Positives = 201/531 (37%), Gaps = 77/531 (14%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V++ +G +   KC ++ +      + W   ++E       +R G      G Y  ++
Sbjct: 7218 PVSVDLALGESGTFKCHVTGTAP--IKITWAKDNRE-------IRPG------GNY--KM 7260

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEY-RIQLRVYKAPEEPNIQVNPLGIPVN 151
            +L +  ATL + +V   D   + C       ++    QL V + P     ++ P  I V 
Sbjct: 7261 TLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIK-KLEPSRI-VK 7318

Query: 152  SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
              E       +G  G P  +V+WYK+            IQ S     S + ++ ++L+  
Sbjct: 7319 QDEFTRYECKIG--GSPEIKVLWYKD---------ETEIQESSKFRMSFVDSV-AVLEMH 7366

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIR 271
             +  +    + CE +    S +     +    P+F        +  P+  LK  D V + 
Sbjct: 7367 NLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRK------KPHPIETLKGAD-VHLE 7419

Query: 272  CLADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLEPARKEHS--GRYECQGLD---L 325
            C   G PP H S  K     R  ++ +  ++N +  +     + +  G Y+C+  +    
Sbjct: 7420 CELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGS 7479

Query: 326  DTMI-SLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQ 384
            DT + S+  +     V  +SD+           G  + L    E ++ +   W +++   
Sbjct: 7480 DTCVGSIALKAPPRFVKKLSDISTVV-------GKEVQLQTTIEGAEPISVVWFKDKGEI 7532

Query: 385  VLERGPV----------LQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMA 434
            V E   +          LQ   ++    G Y C   + +  G+       +++  P  + 
Sbjct: 7533 VRESDNIWISYSENIATLQFSRVEPANAGKYTC--QIKNDAGMQEC-FATLSVLEPATIV 7589

Query: 435  FKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELL- 493
             K   + V       L C  +G P  +  W  +G   E   D +  +S  N +   +++ 
Sbjct: 7590 EKPESIKVTTGDTCTLECTVAGTPELSTKWFKDG--KELTSDNKYKISFFNKVSGLKIIN 7647

Query: 494  ----ETGV-ECTASNDLGKNTSILFLELVNLT---TLTPDSNTTTGLSTST 536
                ++GV      N +GK++    L++ + T   + T     T GLS S+
Sbjct: 7648 VAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSS 7698



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 68/325 (20%), Positives = 116/325 (35%), Gaps = 55/325 (16%)

Query: 166  GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL--VKEDKDAQFYC 223
            G P  +V WY +G  +              ++  G+  +  +   Q+   + +    + C
Sbjct: 4887 GTPKIRVSWYLDGNEIT------------AIQKHGISFIDGLATFQISGARVENSGTYVC 4934

Query: 224  ELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFS 283
            E      + +   E +    P F        E++PV ++K  D VE+ C   G PP   +
Sbjct: 4935 EARNDAGTASCSIELKVKEPPTFIR------ELKPVEVVKYSD-VELECEVTGTPPFEVT 4987

Query: 284  ISKQNPSTREAEEETTNDN-GVLVLEPARKEHS--GRYEC------QGLDLDTMISLLSE 334
              K N   R +++ T  D   V  L   + + S  G Y+C            T ++ L E
Sbjct: 4988 WLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVA-LKE 5046

Query: 335  PQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERG----- 389
            P   +    +   V          SS T       S  +   WL+++  Q+L+       
Sbjct: 5047 PPSFIKKIENTTTVLK--------SSATFQSTVAGSPPISITWLKDD--QILDEDDNVYI 5096

Query: 390  ------PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
                    LQ+  +     G Y C A   S  G+ R     + +  P  +  K + V V 
Sbjct: 5097 SFVDSVATLQIRSVDNGHSGRYTCQAKNES--GVERCYAF-LLVQEPAQIVEKAKSVDVT 5153

Query: 444  ENMVLNLSCEASGHPRPTISWNVNG 468
            E   + L C  +G P   + W  +G
Sbjct: 5154 EKDPMTLECVVAGTPELKVKWLKDG 5178



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 100/508 (19%), Positives = 184/508 (36%), Gaps = 99/508 (19%)

Query: 40   VGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGA 99
            +G++ +L+C ++ S      V WF    EK  ++             +Y+   S  D   
Sbjct: 5813 LGASCILECKVAGSSP--ISVAWFH---EKTKIV----------SGAKYQTTFS--DNVC 5855

Query: 100  TLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVA 159
            TL L  +   D   + C        +   + R     +EP         P   KEPE + 
Sbjct: 5856 TLQLNSLDSSDMGNYTCVAANVAGSD---ECRAVLTVQEP---------PSFVKEPEPLE 5903

Query: 160  TCVGRN--------GYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQ 211
               G+N        G P  +V W++  R L +  +R +I    TV    L+ +       
Sbjct: 5904 VLPGKNVTFTSVIRGTPPFKVNWFRGARELVKG-DRCNIYFEDTVAELELFNIDI----- 5957

Query: 212  LVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIR 271
                 +  ++ C +     S N  + S   T  +F      +L+      ++ G  + + 
Sbjct: 5958 ----SQSGEYTCVV-----SNNAGQAS--CTTRLFVKEPAAFLKRLSDHSVEPGKSIILE 6006

Query: 272  CLADGNPPPHFSISKQNPSTREAEE---ETTNDNGVLVLEPARKEHSGRYECQ-----GL 323
                G  P   +  K   +   +E+    TT    +L +  + K  +G+Y C+     G 
Sbjct: 6007 STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGR 6066

Query: 324  DL-DTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREET 382
            D+   ++S L  P      +V+++    AA     G S++L C+   + ++   W + +T
Sbjct: 6067 DVCGALVSTLEPPY-----FVTELEPLEAAV----GDSVSLQCQVAGTPEITVSWYKGDT 6117

Query: 383  ---------GQVLERGPVLQLHDLKREAGGGYRC-------VASVPSIPGLNRTQLVNVA 426
                              L  + +     G Y C        AS  ++  +   QL    
Sbjct: 6118 KLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL---- 6173

Query: 427  IFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV----LS 482
               PP  A + + +     + + L+C  +G     + W  +G     D++ Q      ++
Sbjct: 6174 ---PPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVA 6230

Query: 483  TLNVLVTPELLETGVECTASNDLGKNTS 510
            TL +L T         C+ASN LG  +S
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASS 6258



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 48/220 (21%), Positives = 93/220 (42%), Gaps = 28/220 (12%)

Query: 315  SGRYECQ-----GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAES 369
            +G+Y C      G D  T + L++EP +        V+   A+   + G S  L C+   
Sbjct: 5397 TGQYTCHVTNDVGSDSCTTMLLVTEPPKF-------VKKLEASKIVKAGDSSRLECKIAG 5449

Query: 370  SQDLEFQWLREE---------TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT 420
            S ++   W R E             ++   V+Q+++L  E  G + C A  P+      T
Sbjct: 5450 SPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCST 5509

Query: 421  QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG---TASEQDQDP 477
            +++   +  PP  +     V   +N  ++L CE SG P   + W  +     +S++ +  
Sbjct: 5510 KVI---VKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSKKYKIA 5566

Query: 478  QRVLSTLNVLVTPELLETG-VECTASNDLGKNTSILFLEL 516
             +   T   ++  +  + G   C A N++G +T +  ++L
Sbjct: 5567 SKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKL 5606



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 69/366 (18%), Positives = 128/366 (34%), Gaps = 50/366 (13%)

Query: 166  GYPIPQVIWYKNGR--PLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYC 223
            G P  +V+W++N    P  ++     I S   ++ + L T  S              F C
Sbjct: 5449 GSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDS------------GDFIC 5496

Query: 224  ELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPH-- 281
            E     P+G     S   +  V      V+    P+    +   V + C   G PP    
Sbjct: 5497 EAQN--PAG-----STSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV 5549

Query: 282  -FSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ-----GLDLDTMISLLSEP 335
             +   +Q  S+++ +  + N +  + +        G Y C+     G D       L EP
Sbjct: 5550 WYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEP 5609

Query: 336  QELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGP----- 390
                V+ ++ + V    P   + S        E +Q +  QWL+E+   + E        
Sbjct: 5610 PRF-VSKLNSLTVVAGEPAELQAS-------IEGAQPIFVQWLKEKEEVIRESENIRITF 5661

Query: 391  ---VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMV 447
               V  L   K E     + +  + +  G+ R  +  + +  P  +  K   + V     
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGM-RENMATLMVLEPAVIVEKAGPMTVTVGET 5720

Query: 448  LNLSCEASGHPRPTISWNVNGTASEQDQDPQ----RVLSTLNVLVTPELLETGVECTASN 503
              L C+ +G P  ++ W  +G      Q  +      +S+L +L               N
Sbjct: 5721 CTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQN 5780

Query: 504  DLGKNT 509
            ++GK++
Sbjct: 5781 NVGKSS 5786



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 79/356 (22%), Positives = 135/356 (37%), Gaps = 61/356 (17%)

Query: 38    VEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDR 97
             VE G+TA+L+C +S+     + V WF             + G    +  +YE  +    R
Sbjct: 12296 VEEGATAVLECEVSREN---AKVKWF-------------KNGTEILKSKKYE--IVADGR 12337

Query: 98    GATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQ-VNPL-GIPVNSKEP 155
                L +   TP+D + + C  K     +++    +   P  P+++ + PL  + V  KE 
Sbjct: 12338 VRKLVIHDCTPEDIKTYTCDAK-----DFKTSCNLNVVP--PHVEFLRPLTDLQVREKEM 12390

Query: 156   EEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKE 215
                   + R      +V W+K+G  +K+ K          + S G   +  I K  L   
Sbjct: 12391 ARFECELSREN---AKVKWFKDGAEIKKGK-------KYDIISKGAVRILVINKCLL--- 12437

Query: 216   DKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLAD 275
             D +A++ CE+     SG       E          K    +E    + E D +++ C   
Sbjct: 12438 DDEAEYSCEVRTARTSGMLTVLEEEAVF------TKNLANIE----VSETDTIKLVCEVS 12487

Query: 276   --GNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLS 333
               G     +   ++   T   E  T     +LV++ A  E +G Y C+     T   +  
Sbjct: 12488 KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKV-- 12545

Query: 334   EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERG 389
             +  EL   ++S     P   E  EG      C   S +    QW R++  + LE G
Sbjct: 12546 KVHELAAEFIS----KPQNLEILEGEKAEFVCSI-SKESFPVQWKRDD--KTLESG 12594



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 71/346 (20%), Positives = 125/346 (36%), Gaps = 45/346 (13%)

Query: 81   GQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPN 140
            GQ  P   + ++  +D+ ATL +     +D   ++C                 + P    
Sbjct: 3681 GQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFV 3740

Query: 141  IQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKN-RVHIQSSQTVESS 199
             +V+P  + +     E         G P+ QV W+KN + L E    R++  +S      
Sbjct: 3741 KKVDPSYLMLPG---ESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNS------ 3791

Query: 200  GLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPV 259
                 ++IL    VK +    + CE    + S +   E      P F  T      +EP 
Sbjct: 3792 -----EAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKT------LEPA 3840

Query: 260  GMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLE--PARKEHSG 316
             +++ G    ++C   G  P   S  K     R +++    +   ++ LE         G
Sbjct: 3841 DIVR-GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVG 3899

Query: 317  RYECQGLD----LDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQD 372
             YEC   +       M + L +     V  V D+           G ++TL      S+ 
Sbjct: 3900 EYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIA-------LGGQTVTLQAAVRGSEP 3952

Query: 373  LEFQWLR-----EETGQV---LERG-PVLQLHDLKREAGGGYRCVA 409
            +   W++      E G++      G  VL + D++   GG Y C+A
Sbjct: 3953 ISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLA 3998



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 57/259 (22%), Positives = 99/259 (38%), Gaps = 35/259 (13%)

Query: 276  GNPPPHFSISKQNPSTREAEE---ETTNDNGVLVLEPARKEHSGRYEC-----QGLDLDT 327
            G PP   +  K   +   ++     TT  + +L +  +  E +G+Y C      G D  +
Sbjct: 7893 GTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCS 7952

Query: 328  MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLE 387
               L+ EP    V  +  V+VS        G S +L C+   + ++   W + +T   L 
Sbjct: 7953 AQILILEPP-YFVKQLEPVKVSV-------GDSASLQCQLAGTPEIGVSWYKGDTK--LR 8002

Query: 388  RGPVLQLHDLKREA-----------GGGYRCVASVPSIPGLNRTQLVNVAIFG-PPWMAF 435
                 ++H     A            G Y C A   S+  ++ +  + V     PP  + 
Sbjct: 8003 PTTTYKMHFRNNVATLVFNQVDINDSGEYICKAE-NSVGEVSASTFLTVQEQKLPPSFSR 8061

Query: 436  KERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL----STLNVLVTPE 491
            + R V     + +   C  SG    ++SW  +G   +   + Q       +TLN+  T  
Sbjct: 8062 QLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDR 8121

Query: 492  LLETGVECTASNDLGKNTS 510
             L     CTA+N +G  +S
Sbjct: 8122 SLAGQYSCTATNPIGSASS 8140



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 53/236 (22%), Positives = 92/236 (38%), Gaps = 46/236 (19%)

Query: 264  EGDRVEIRCLADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLE--PARKEHSGRYEC 320
            EG+  ++     G+ P   +  K N   +     E T  N  LVL+   A    +G Y C
Sbjct: 8263 EGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTC 8322

Query: 321  Q-----GLDLDTMISLLSEPQELLV--NYVSDVRVSPAAPERQEGSSLTLTCEAESSQDL 373
            +     G  L T   ++ EP++  V   +++ V VS       EG  + L+C  + S+ +
Sbjct: 8323 KVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS-------EGEYVQLSCHVQGSEPI 8375

Query: 374  EFQWLREETGQVLERG-----------PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQ- 421
              QWL+   G+ ++              VL+L D+ +   G Y C AS  ++ G + T+ 
Sbjct: 8376 RIQWLK--AGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKAS--NVAGSDTTKS 8431

Query: 422  -------------LVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
                             A+ G  +   + + + V E        +  G P P + W
Sbjct: 8432 KVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKW 8487



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 95/449 (21%), Positives = 156/449 (34%), Gaps = 76/449 (16%)

Query: 112  RIFLCQGKRPRSQEY-------RIQLRVY-KAPEEPNIQVNPLGIPVNSKEPEEVATCVG 163
            R+F+ + ++  + EY       R  + +Y  APE P +      + V S +P     C  
Sbjct: 3204 RMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARF--CAV 3261

Query: 164  RNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYC 223
             +G P P++ WYK  + L        +   Q       YTL   L  +   ED  A + C
Sbjct: 3262 ISGRPQPKISWYKEEQLLSTGFKCKFLHDGQE------YTL---LLIEAFPEDA-AVYTC 3311

Query: 224  ELN----YRLPSGNHMKESREVT-----VPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLA 274
            E          S +   E  EV      +PV+ P     L+     +  EG     +C  
Sbjct: 3312 EAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDT---VTSEGQPARFQCRV 3368

Query: 275  DGNP--PPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRY------------EC 320
             G       +S  K+   +R        D   L +  A  E  G Y              
Sbjct: 3369 SGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSST 3428

Query: 321  QGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTL------TCEAESSQDLE 374
              L L+   S+L E  E  +    +++ +P    + E   + L      TCE +S+ ++ 
Sbjct: 3429 ANLSLEAPESILHERIEQEIEM--EMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVR 3486

Query: 375  FQWLR-------EETGQVLERGPVLQLHDLKREA--GGGYRCVASVPSIPGLNRTQLVNV 425
            FQW +        +   +     +  L  L+ +    G Y C AS      ++ T  + V
Sbjct: 3487 FQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKAS-NEYGSVSCTATLTV 3545

Query: 426  AIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASE-------QDQDPQ 478
                PP    + + +           C  +G P     W  +G A          D + +
Sbjct: 3546 TEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENK 3605

Query: 479  RVLSTLNVLVTPELLETGV-ECTASNDLG 506
             +L   N+ +     + GV  C ASN  G
Sbjct: 3606 HILELSNLTIQ----DRGVYSCKASNKFG 3630



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 61/304 (20%), Positives = 117/304 (38%), Gaps = 36/304 (11%)

Query: 85   PGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVN 144
            P   + R++  D  A + +  ++ +D   F+C+ + P          + K P   +    
Sbjct: 5465 PASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFS-SFP 5523

Query: 145  PLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTL 204
            P+   V + +  EV+     +G P  +V+WYK+ R L+  K          + S   +T 
Sbjct: 5524 PI---VETLKNAEVSLECELSGTPPFEVVWYKDKRQLRSSK-------KYKIASKNFHTS 5573

Query: 205  QSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKE 264
              IL    V      +++C+    + S   +   +    P F         V        
Sbjct: 5574 IHILN---VDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVV-------A 5623

Query: 265  GDRVEIRCLADGNPPPHFSISKQNPST-REAEE-ETTNDNGVLVLEPARKE--HSGRYEC 320
            G+  E++   +G  P      K+     RE+E    T    V  L+ A+ E  ++G+Y C
Sbjct: 5624 GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYIC 5683

Query: 321  Q----GLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQ 376
            Q    G   + M +L+     ++V     + V+        G + TL C+   + +L  +
Sbjct: 5684 QIKNDGGMRENMATLMVLEPAVIVEKAGPMTVT-------VGETCTLECKVAGTPELSVE 5736

Query: 377  WLRE 380
            W ++
Sbjct: 5737 WYKD 5740



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 69/351 (19%), Positives = 133/351 (37%), Gaps = 57/351 (16%)

Query: 150  VNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKE-------EKNRVHIQSSQTVESSGLY 202
            V +KE + +AT       P  +V WYK+G  + E          +VH  S  T+++S   
Sbjct: 2183 VVAKEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAE 2242

Query: 203  TLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGML 262
                +L      ED++ +   +L         +KE +++ VP  Y  E   + V P  + 
Sbjct: 2243 DYSCVL-----VEDENVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECI-VSPENIE 2296

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQG 322
             +    ++   ++G         K   ++R   +        L ++   KE  G Y    
Sbjct: 2297 GKWYHNDVELKSNG---------KYTITSRRGRQN-------LTVKDVTKEDQGEYSFVI 2340

Query: 323  LDLDTMISLLSEPQEL-LVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREE 381
                T   L  +P+ + ++  +SD +V        EG  + L  +  S + +E  W+++ 
Sbjct: 2341 DGKKTTCKLKMKPRPIAILQGLSDQKVC-------EGDIVQLEVKV-SLESVEGVWMKD- 2391

Query: 382  TGQVLE-----------RGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
             GQ ++           +  +L + D+ +E  G Y        +    R  + +V +  P
Sbjct: 2392 -GQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALGLSTSGRVSVYSVDVITP 2450

Query: 431  PWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL 481
                   + V V E     L C+ S     ++ W +N    + D   Q ++
Sbjct: 2451 ------LKDVNVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIV 2495



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 11/122 (9%)

Query: 204  LQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLE-VEPVGML 262
            L+S L+  LVK      + C+++       ++    E +  +F      ++E +EP  +L
Sbjct: 4259 LESSLELYLVKTSDSGTYTCKVS-------NVAGGVECSANLFVKEPATFVEKLEPSQLL 4311

Query: 263  KEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEET---TNDNGVLVLEPARKEHSGRYE 319
            K+GD  ++ C   G PP   +    +   +E+ +          VL L     E SG Y 
Sbjct: 4312 KKGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYM 4371

Query: 320  CQ 321
            C+
Sbjct: 4372 CE 4373



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 43/230 (18%), Positives = 87/230 (37%), Gaps = 31/230 (13%)

Query: 262   LKEGDRVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLE--PARKEHSGRY 318
             + EG  V   C   G P P     K N P +  +    +    V  LE   A    SG+Y
Sbjct: 33145 INEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKY 33204

Query: 319   ---------ECQGLDLDTMISLLSEPQELLV----------NYVSDVRVSPAAPERQEGS 359
                      +C       ++ L+ EP   +V             S   V  +A +++   
Sbjct: 33205 TIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASF 33264

Query: 360   SLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNR 419
             S   +  A S  +++F  +  ++   ++   V         +   +  ++++  +   + 
Sbjct: 33265 SSFSSSSASSMTEMKFASMSAQSMSSMQESFV-------EMSSSSFMGISNMTQLES-ST 33316

Query: 420   TQLVNVAIFG-PPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             ++++   I G PP +      + + E  VL ++C  +G P P ++W+  G
Sbjct: 33317 SKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGG 33366



 Score = 36.6 bits (83), Expect = 0.074
 Identities = 73/309 (23%), Positives = 118/309 (38%), Gaps = 45/309 (14%)

Query: 172   VIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPS 231
             V W+K+G+ +K  KN V       +++ G   +  + KA  +K D   Q+ C+      S
Sbjct: 12048 VKWFKDGKEIKPSKNAV-------IKADGKKRMLILKKA--LKSD-IGQYTCDCGTDKTS 12097

Query: 232   GNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPST 291
             G    E RE+ +     + +V +E E      E    +I      N         Q P  
Sbjct: 12098 GKLDIEDREIKLVRPLHSVEV-METETARFETEISEDDIH----ANWKLKGEALLQTPDC 12152

Query: 292   REAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQEL-LVNYVSDVRVSP 350
                EE   +    LVL   R + +G  + Q  ++ +   L  +P+ + L+  + DV V+ 
Sbjct: 12153 EIKEEGKIHS---LVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVTVT- 12208

Query: 351   AAPERQEGSSLTLTCEAESSQDLEFQWL-----REETGQVLERGP----VLQLHDLKREA 401
                    G + T  CE  S +D+  +W       E + +V+ R       L L D+K E 
Sbjct: 12209 ------AGETATFDCEL-SYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLED 12261

Query: 402   GGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKE-RKVWVKENMVLNLSCEASGHPRP 460
              G  +  A        +     N+ +  PP    K      V+E     L CE S     
Sbjct: 12262 AGEVQLTAK-------DFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVS-RENA 12313

Query: 461   TISWNVNGT 469
              + W  NGT
Sbjct: 12314 KVKWFKNGT 12322



 Score = 36.2 bits (82), Expect = 0.096
 Identities = 91/427 (21%), Positives = 159/427 (37%), Gaps = 81/427 (18%)

Query: 81   GQSEPGEYEQRLSLQDRGA-TLALTQVTPQD--ERIFLCQGKRPRSQEYRIQLRVYKAPE 137
            GQ    +Y  ++ +++ G  +L +   TP D  E   + Q +  RS      + V    E
Sbjct: 1494 GQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSS-----ISVILTVE 1548

Query: 138  EPNIQVNPLGIP----VNSKEPEEVATCVGRNGYPIPQVIWYKNGR---PLKEEKNRVH- 189
                QV P+ +     VN KE   +   V   G P P ++W KN     P K  K R+  
Sbjct: 1549 AVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEG 1608

Query: 190  ------IQSSQTV-ESSGLYTLQSILKA-------QLVKEDKDAQFYCELNYRLPSGNHM 235
                  ++   TV + S  YT  +I KA       ++  E + A+   E    +P G + 
Sbjct: 1609 TKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERKLIIPRGTY- 1667

Query: 236  KESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFS-------ISKQN 288
              ++E+  P   P    + + +     +EGD  +     +    P F        + +  
Sbjct: 1668 -RAKEIAAPELEPLHLRYGQEQ----WEEGDLYD----KEKQQKPFFKKKLTSLRLKRFG 1718

Query: 289  PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSE----PQELLVNYVS 344
            P+  E       D  ++V       H G+     L+    + +++E      +  V Y  
Sbjct: 1719 PAHFECRLTPIGDPTMVV----EWLHDGK----PLEAANRLRMINEFGYCSLDYGVAYSR 1770

Query: 345  DVRVSPAAPERQEG---SSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREA 401
            D  +       + G   +S TL  + E S       L EE+     R  + ++ +L+R A
Sbjct: 1771 DSGIITCRATNKYGTDHTSATLIVKDEKS-------LVEESQLPEGRKGLQRIEELERMA 1823

Query: 402  GGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPT 461
              G    A           Q  ++ ++  P        V V E       C  +G+P+P 
Sbjct: 1824 HEG----ALTGVTTDQKEKQKPDIVLYPEP--------VRVLEGETARFRCRVTGYPQPK 1871

Query: 462  ISWNVNG 468
            ++W +NG
Sbjct: 1872 VNWYLNG 1878



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 49/210 (23%), Positives = 76/210 (36%), Gaps = 30/210 (14%)

Query: 101  LALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT 160
            +++T  T ++ER  +  G+  +  E        + P  P   V+ L   V   E E V  
Sbjct: 904  VSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLK-NVTVIEGESVTL 962

Query: 161  CVGRNGYPIPQVIWYKNGRPLKEEKN-RVHIQSSQT--------VESSGLYTLQSILKAQ 211
                +GYP P V WY+    ++   + ++  QS            E SG +T  ++ +A 
Sbjct: 963  ECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAG 1022

Query: 212  LVK----------EDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEP--- 258
             V           E+ + +                ESR+V +     TE+     EP   
Sbjct: 1023 TVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAP 1082

Query: 259  -------VGMLKEGDRVEIRCLADGNPPPH 281
                   V  L EG  V   C   GNP PH
Sbjct: 1083 YFITKPVVQKLVEGGSVVFGCQVGGNPKPH 1112



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 51/230 (22%), Positives = 88/230 (38%), Gaps = 26/230 (11%)

Query: 357 EGSSLTLTCEAESSQDLEFQWLREETGQVLERGPV-------------LQLHDLKREAGG 403
           EGS+ T           E  W R+  GQV+    +             L +  + +   G
Sbjct: 19  EGSTATFEAHISGFPVPEVSWFRD--GQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76

Query: 404 GYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTIS 463
            Y   A+  S    +  +L+  A   PP    + + + V++   + L    +G P P + 
Sbjct: 77  RYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVK 136

Query: 464 WNVNGTASEQDQDPQ-----RVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVN 518
           +  +G   +   D Q      + S L     PE   T     A+N +G+ TS   L LV 
Sbjct: 137 FYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGT-YSVNATNSVGRATSTAEL-LVQ 194

Query: 519 LTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEP-ESRGVVIVAVIV 567
                P   T T +ST+  S    +  T  E+K+    ++R +  V +++
Sbjct: 195 GEEEVPAKKTKTIVSTAQIS---ESRQTRIEKKIEAHFDARSIATVEMVI 241



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 17/131 (12%)

Query: 89    EQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQ---EYRIQLRVYKAPEEPNIQVNP 145
             E R  +     TL + Q + +DE I  C  K        +Y + L   +  + P     P
Sbjct: 33082 EYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSK-ELSDAPAFISQP 33140

Query: 146   LGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES------- 198
                 +N  E + V      +G P P++ W+KN  P+    N V I  S+ V S       
Sbjct: 33141 RSQNIN--EGQNVLFTCEISGEPSPEIEWFKNNLPISISSN-VSISRSRNVYSLEIRNAS 33197

Query: 199   ---SGLYTLQS 206
                SG YT+++
Sbjct: 33198 VSDSGKYTIKA 33208



 Score = 33.9 bits (76), Expect = 0.48
 Identities = 76/396 (19%), Positives = 150/396 (37%), Gaps = 52/396 (13%)

Query: 89   EQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGI 148
            + R+S  +  A L LT V  +D   ++C+ +     ++   + + K       +  P+ +
Sbjct: 4345 KHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEV 4404

Query: 149  PVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKE-EKNRVHIQSSQTVESSGLYTLQSI 207
                 +  +V       G P  ++ W+K+   L+   K +  IQ         L +LQ I
Sbjct: 4405 ----LKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDH-------LVSLQ-I 4452

Query: 208  LKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDR 267
            LK   V  D   ++ C +   +  G+ +  +R   V +  P   +  ++E    L+ G  
Sbjct: 4453 LK--FVAADA-GEYQCRVTNEV--GSSICSAR---VTLREPPSFI-KKIESTSSLRGGTA 4503

Query: 268  VEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGV--LVLEPARKEHSGRYECQ---- 321
                 L    P     +   +  T +     T +N V  L L     +H G+Y CQ    
Sbjct: 4504 AFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563

Query: 322  -GLDLDTMISLLSEPQELLVNYVS-DVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLR 379
             G+   + +  + EP  +    VS DV          +G   TL  +   ++++  +W +
Sbjct: 4564 AGIQRCSALLSVKEPATITEEAVSIDV---------TQGDPATLQVKFSGTKEITAKWFK 4614

Query: 380  EETGQVLERG-----------PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
            +  GQ L  G            +L++   +++  G Y             + ++  + + 
Sbjct: 4615 D--GQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLI 4672

Query: 429  GPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
             PP    K +K+   +   ++L C  +G    +I W
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQW 4708



 Score = 33.5 bits (75), Expect = 0.62
 Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 25/92 (27%)

Query: 124   QEYRIQLRVY--KAPEEPNIQVNPLGIPVNSKE------------------PEEVATCVG 163
             QEY+ +++ Y  K   +P +    LG+PV +K+                   E++   + 
Sbjct: 24279 QEYQFRVKAYNEKGKSDPRV----LGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIP 24334

Query: 164   RNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQT 195
               G P P + W K+G PLK +  RV+++ + T
Sbjct: 24335 VIGRPRPNISWVKDGEPLK-QTTRVNVEETAT 24365



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 13/28 (46%), Positives = 20/28 (71%)

Query: 166   GYPIPQVIWYKNGRPLKEEKNRVHIQSS 193
             G PIP V+W K+G+ L+E   R+ I+S+
Sbjct: 24733 GKPIPDVVWSKDGKELEETAARMEIKST 24760



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 78/387 (20%), Positives = 131/387 (33%), Gaps = 57/387 (14%)

Query: 148  IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
            I V + +P  +   V   G P  +  WYK+GRPL   K +  I     V     Y+    
Sbjct: 4026 IQVTAGDPATLEYTVA--GTPELKPKWYKDGRPLVASK-KYRISFKNNVAQLKFYS---- 4078

Query: 208  LKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDR 267
                       A+ +    Y     N +  S   T       +      +P   L+  D 
Sbjct: 4079 -----------AELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKP---LRNVDS 4124

Query: 268  V-----EIRCLADGNPPPHFSISKQNPSTREAEE-ETTNDNGVLVLEPARKE--HSGRYE 319
            V      + C   G+ P   S  K       ++        G   LE  R +   +G + 
Sbjct: 4125 VVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFT 4184

Query: 320  CQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLR 379
            C+  +    +        L+V         P + +   GS++ L    + S  L  +W +
Sbjct: 4185 CRATN---SVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFK 4241

Query: 380  EE-----------TGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
                         T + LE    L+L+ +K    G Y C   V ++ G       N+ + 
Sbjct: 4242 GNKELVSGGSCYITKEALESS--LELYLVKTSDSGTYTC--KVSNVAGGVECS-ANLFVK 4296

Query: 429  GPPWMAFK-ERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVL 487
             P     K E    +K+     L+C+ +G P   I+W  N    E  +  +  +S +   
Sbjct: 4297 EPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFAND--REIKESSKHRMSFVEST 4354

Query: 488  VTPELLETGVE------CTASNDLGKN 508
                L + G+E      C A N+ G +
Sbjct: 4355 AVLRLTDVGIEDSGEYMCEAQNEAGSD 4381



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 13/35 (37%), Positives = 19/35 (54%)

Query: 430 PPWMAFKERKVWVKENMVLNLSCEASGHPRPTISW 464
           PP +    + V V E   + L C  SG+P PT++W
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTW 976



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 49/220 (22%), Positives = 78/220 (35%), Gaps = 35/220 (15%)

Query: 167  YPIPQVIWYKNGRPLK-EEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCEL 225
            YP  ++ WYK    L+  +K  + I   +       +TL+           K+ Q   + 
Sbjct: 8683 YPEIKLSWYKGTEKLEPSDKFEISIDGDR-------HTLRV----------KNCQLKDQG 8725

Query: 226  NYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSIS 285
            NYRL  G H+  ++   +      E  W        LKEG    + C             
Sbjct: 8726 NYRLVCGPHIASAKLTVI------EPAWERHLQDVTLKEGQTCTMTCQFSVPNVKSEWFR 8779

Query: 286  KQNPSTREAEEETTNDNGV--LVLEPARKEHSGRYECQGLDLDTMISLLSEPQEL-LVNY 342
                   +   +T  ++ V  L +   R E  G+Y C+  DL+T   L  E + +     
Sbjct: 8780 NGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKR 8839

Query: 343  VSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREET 382
            + ++ VS       E  S T  CE  S  D    W +  T
Sbjct: 8840 IQNIVVS-------EHQSATFECEV-SFDDAIVTWYKGPT 8871



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 45/186 (24%), Positives = 79/186 (42%), Gaps = 13/186 (6%)

Query: 118   GKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKN 177
             G+   S    + ++  + P    ++++  G  +  K  E V       G P+P++ W KN
Sbjct: 15376 GESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKN 15435

Query: 178   GRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHM-K 236
                +++  + + I + + V  S   T  SI KA  V+EDK         Y + + N +  
Sbjct: 15436 ETVIEKPTDALQI-TKEEVSRSEAKTELSIPKA--VREDKG-------TYTVTASNRLGS 15485

Query: 237   ESREVTVPVF-YPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAE 295
               R V V V+  P+    L V  +         +      G+   H+ I K++ S ++AE
Sbjct: 15486 VFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAE 15545

Query: 296   -EETTN 300
              EE TN
Sbjct: 15546 WEEVTN 15551



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 1/48 (2%)

Query: 151   NSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES 198
             N K  E++   V   G P   V W K+G+ LK E  RV++ SS+TV S
Sbjct: 25405 NVKAREQLKIDVPFKGRPQATVNWRKDGQTLK-ETTRVNVSSSKTVTS 25451



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 9/18 (50%), Positives = 16/18 (88%)

Query: 165  NGYPIPQVIWYKNGRPLK 182
            +GYP+P++ WYK+G+ +K
Sbjct: 1315 SGYPLPKIAWYKDGKRIK 1332



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 2/52 (3%)

Query: 134  KAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEK 185
            K  ++P+I + P   PV   E E         GYP P+V WY NG+ +++ K
Sbjct: 1836 KEKQKPDIVLYPE--PVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSK 1885



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 76/374 (20%), Positives = 139/374 (37%), Gaps = 47/374 (12%)

Query: 166  GYPIPQVIWYKNGRPLKE-EKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCE 224
            G P  ++ W+ N R +KE  K+R+       VES+      ++L+   V  +   ++ CE
Sbjct: 4325 GTPPIKITWFANDREIKESSKHRMSF-----VEST------AVLRLTDVGIEDSGEYMCE 4373

Query: 225  LNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSI 284
                  + N        ++ +   +     E +P+ +LKE D V +     G PP   + 
Sbjct: 4374 ------AQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYD-VMLLAEVAGTPPFEITW 4426

Query: 285  SKQNPSTREAEEETTNDNGVLVLEPARK---EHSGRYECQ-----GLDLDTMISLLSEPQ 336
             K N   R   +  T     LV     K     +G Y+C+     G  + +    L EP 
Sbjct: 4427 FKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPP 4486

Query: 337  ELL--VNYVSDVRVSPAAPERQEGSSLTLTC-----EAESSQDLEFQWLREETGQVLERG 389
              +  +   S +R   AA +     SL +T        E ++D   +   E     L   
Sbjct: 4487 SFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLS 4546

Query: 390  PVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLN 449
             +   HD      G Y C A   +  G+ R   + +++  P  +  +   + V +     
Sbjct: 4547 GIEVKHD------GKYVCQAK--NDAGIQRCSAL-LSVKEPATITEEAVSIDVTQGDPAT 4597

Query: 450  LSCEASGHPRPTISWNVNG----TASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDL 505
            L  + SG    T  W  +G      S+        +S L ++ T +           ND+
Sbjct: 4598 LQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDV 4657

Query: 506  GKNTSILFLELVNL 519
            G+++    + +++L
Sbjct: 4658 GRSSCKARINVLDL 4671



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 13/77 (16%)

Query: 139   PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPL-KEEKNRVHIQSSQTV- 196
             P I+  P  I ++  +   VA      G P P+V W   GR +  +E+ R HI+++  + 
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAF--TGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386

Query: 197   ---------ESSGLYTL 204
                      +  GLYTL
Sbjct: 33387 TLIIMDVQKQDGGLYTL 33403



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 51/227 (22%), Positives = 86/227 (37%), Gaps = 34/227 (14%)

Query: 168   PIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNY 227
             P  +V WY NG  L +E +++H        +SG+ TL+ +          D        Y
Sbjct: 32401 PTAEVKWYHNGVEL-QESSKIHY-----TNTSGVLTLEIL----------DCHTDDSGTY 32444

Query: 228   RLPSGNHMKESRE-VTVPV------FYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPP 280
             R    N+  E+ +  T+ V       Y +++   EV P  +  E  R E   ++      
Sbjct: 32445 RAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEV-PRSVFPELTRTEAYAVSSFKKTS 32503

Query: 281   HFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDL-DTMISLLSEPQELL 339
                 S    S RE + + T     L    +  EHS   E +   L +  +   S  +++ 
Sbjct: 32504 EMEASS---SVREVKSQMTETRESL----SSYEHSASAEMKSAALEEKSLEEKSTTRKIK 32556

Query: 340   VNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL 386
                 + +   P +    EG S   +C+ +        WLR+  GQVL
Sbjct: 32557 TTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRK--GQVL 32601



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 39/170 (22%), Positives = 63/170 (37%), Gaps = 22/170 (12%)

Query: 357  EGSSLTLTCEAESSQDLEFQWLREETG---------QVLERGPVLQLHDLKREAGGGYRC 407
            +GS + L C    S  +  QW +++              +    L++  L+    G Y C
Sbjct: 4688 KGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTC 4747

Query: 408  VASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNV- 466
              S  +  G N+    ++ +  PP+   K +   V  N  + L     G    TI W   
Sbjct: 4748 --SATNKAGHNQCS-GHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKD 4804

Query: 467  -----NGTASEQDQDPQRVLSTLNVLVTPELLETGVE-CTASNDLGKNTS 510
                 +G A    +D     ST   L   +  ++G   C  SND+G  TS
Sbjct: 4805 NKELHSGAARSVWKDD---TSTSLELFAAKATDSGTYICQLSNDVGTATS 4851



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 32/137 (23%), Positives = 53/137 (38%), Gaps = 18/137 (13%)

Query: 343  VSDVRVSPAAPERQE------GSSLTLTCEAESSQDLEFQWLREETGQV---------LE 387
            VSD  V P+   R +      G+S  L C+   S  +   W  E+T  V          +
Sbjct: 5793 VSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD 5852

Query: 388  RGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMV 447
                LQL+ L     G Y CVA+  ++ G +  + V + +  PP    +   + V     
Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAA--NVAGSDECRAV-LTVQEPPSFVKEPEPLEVLPGKN 5909

Query: 448  LNLSCEASGHPRPTISW 464
            +  +    G P   ++W
Sbjct: 5910 VTFTSVIRGTPPFKVNW 5926



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 44/221 (19%), Positives = 88/221 (39%), Gaps = 19/221 (8%)

Query: 352   APERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASV 411
             +P  ++G S       E  ++ + +W + +  +V  RG  L +  LK   G  Y+     
Sbjct: 16442 SPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEV--RGTKLVVTGLKE--GAFYKFRVRA 16497

Query: 412   PSIPGLNR----TQLVNVA--IFGPPWM--AFKERKVWVKENMVLNLSCEASGHPRPTIS 463
              +I G+      T ++ +   +  P     A    ++ V    V+ +    SG P PT++
Sbjct: 16498 VNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVT 16557

Query: 464   WNVNGTASEQDQDPQ-RVLSTLNVLVTPELLETGV-ECTASNDLGKNTSILFLELVNL-- 519
             WN+N     Q+   +   +S+  V+   +    GV    A N+ G+    + ++++++  
Sbjct: 16558 WNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPG 16617

Query: 520   ---TTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPES 557
                T     + T      +  SP     S  T   + + ES
Sbjct: 16618 PVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRES 16658



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 27/123 (21%)

Query: 166  GYPIPQVIWYKNGRPLKEE-KNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCE 224
            G P+P+  W+ +G+ +  +  ++V I+   T         QS++       D        
Sbjct: 1482 GRPMPETFWFHDGQQIVNDYTHKVVIKEDGT---------QSLIIVPATPSDSG------ 1526

Query: 225  LNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM-------LKEGDRVEIRCLADGN 277
              + + + N    S   ++ V    E V  +V+P+ +       +KEG R+E++  A GN
Sbjct: 1527 -EWTVVAQNRAGRS---SISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGN 1582

Query: 278  PPP 280
            P P
Sbjct: 1583 PNP 1585



 Score = 29.6 bits (65), Expect = 9.0
 Identities = 20/76 (26%), Positives = 34/76 (44%), Gaps = 11/76 (14%)

Query: 152   SKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKN-RVHIQSSQTVESSGLYTLQSILKA 210
             SKE  ++   V  +     +V WYK+G+ LKE  + + H  +  T E          LK 
Sbjct: 32729 SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYE----------LKI 32778

Query: 211   QLVKEDKDAQFYCELN 226
               + E    ++ CE++
Sbjct: 32779 NNLTESDQGEYVCEIS 32794


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 103/451 (22%), Positives = 168/451 (37%), Gaps = 67/451 (14%)

Query: 82  QSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNI 141
           +S+  + + R+ +  +G TL +  V P+D   + CQ       +       Y  P     
Sbjct: 527 ESQALQEDSRIHVDAQG-TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPS--- 582

Query: 142 QVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNG-----RPLKEEKNRVHIQSSQTV 196
            V+ +   V     EE       +G P P+VIWY+ G      P      ++ I ++Q  
Sbjct: 583 -VSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQE- 640

Query: 197 ESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKE-SREVTVPVFYPTEKVWLE 255
             +G YT ++      V E  DA    E+   +     + E  R+VTV +          
Sbjct: 641 RDAGTYTCRA------VNELGDAS--AEIQLAVGHAPQLTELPRDVTVEL---------- 682

Query: 256 VEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPS-------TREAEEETTNDNGVLVLE 308
                    G    + C A G PPP  +  + +                   D+GVL  E
Sbjct: 683 ---------GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFE 733

Query: 309 PARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQ--EGSSLTLTCE 366
               E    Y C+  ++      +     L+V   +  +++ +AP  +  EG  ++L C 
Sbjct: 734 SVAPEDQAPYVCEARNV---FGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCI 790

Query: 367 AESSQDL-EFQWLREETGQVLERGP--------VLQLHDLKREAGGGYRCVASVPSIPGL 417
             + + L E  WL++  G+ L  G          L L    +E  G Y CVA+  +  G 
Sbjct: 791 VLAGRPLPERHWLKD--GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT--NTAGS 846

Query: 418 NRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDP 477
                V + +  PP +          E +  +L C ASG P PTI+W     A       
Sbjct: 847 QHRD-VELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905

Query: 478 QRVLSTLNVLVT-PELLETGV-ECTASNDLG 506
             V     +L+  P   + G   CTA+N +G
Sbjct: 906 YNVSKEGTLLIAQPSAQDAGAYVCTATNTVG 936



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 54/211 (25%), Positives = 88/211 (41%), Gaps = 22/211 (10%)

Query: 264 EGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ-- 321
           +G  V++ C A G P PH S S+++ + +E      +  G L+++    E +G Y CQ  
Sbjct: 504 QGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 563

Query: 322 ---GLDLDTMISLLSEPQEL-LVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQW 377
              G D +T+    ++P  +  VN V  V V         G    L CEA         W
Sbjct: 564 NEVGTDQETVTLYYTDPPSVSAVNAVVLVAV---------GEEAVLVCEASGVPPPRVIW 614

Query: 378 LREETGQVL----ERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM 433
            R     +L         L++   +    G Y C A V  +   + +  + +A+   P +
Sbjct: 615 YRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRA-VNELG--DASAEIQLAVGHAPQL 671

Query: 434 AFKERKVWVKENMVLNLSCEASGHPRPTISW 464
               R V V+      L+C A+G P PT++W
Sbjct: 672 TELPRDVTVELGRSALLACRATGRPPPTVTW 702



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 84/397 (21%), Positives = 143/397 (36%), Gaps = 54/397 (13%)

Query: 33   PELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRL 92
            P  V VE+G +ALL C  +        V W     + + L  R+  G+G           
Sbjct: 675  PRDVTVELGRSALLACRATGRPPPT--VTWR--RGDGQPLGLRLGAGRGSR--------- 721

Query: 93   SLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNS 152
            S Q     L    V P+D+  ++C+ +    +       +      P I  +   + V  
Sbjct: 722  SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 781

Query: 153  KEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQL 212
             +P  +  C+   G P+P+  W K+GRPL          S  ++ + G   L   L    
Sbjct: 782  GQPVSLP-CIVLAGRPLPERHWLKDGRPLPP-------GSRHSIRADGSLHLDRAL---- 829

Query: 213  VKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRC 272
              ++   ++ C       S +   E      P  +PT    +         EG    + C
Sbjct: 830  --QEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI-------TNEGVPASLPC 880

Query: 273  LADGNPPPHFSISKQ-NPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISL 331
            +A G P P  + +K+ N  T        +  G L++     + +G Y C   +    +  
Sbjct: 881  VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN---TVGF 937

Query: 332  LSEPQELLVNYVSDVRVS-------PAAPERQEGSSLTLTCEAESSQDLEFQWLREETG- 383
             S+   L VN    + ++       P     + G  +TL CEA+ S      W ++    
Sbjct: 938  SSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPV 997

Query: 384  -------QVLERGPVLQLHDLKREAGGGYRCVASVPS 413
                    +L  G  L+L  ++    G Y C AS P+
Sbjct: 998  PPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASNPA 1033



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 66/253 (26%), Positives = 100/253 (39%), Gaps = 36/253 (14%)

Query: 282 FSISKQNPSTREAEEETTNDNGVLVLEPAR--KEHSGRYECQGLD------LDTMISLLS 333
           F +  +    R  EE    ++G    E  R  K   G YEC  +           I +  
Sbjct: 339 FRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD 398

Query: 334 EPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQ 393
            P +L+     +V VSP       G +  L+C           W+R+        G V Q
Sbjct: 399 PPPQLVP--APNVTVSP-------GETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ 449

Query: 394 LHDLKREA-------GGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENM 446
           L DL  E        GG Y+CVAS  +  G+ R   V + +   P ++         + +
Sbjct: 450 LADLSLEISGIIPTDGGRYQCVAS--NANGVTRAS-VWLLVREAPQVSIHTSSQHFSQGV 506

Query: 447 VLNLSCEASGHPRPTISWNVNGTASEQDQ----DPQRVLSTLNVLVTPELLETG-VECTA 501
            + +SC ASG+P P ISW+    A ++D     D Q  L      V PE  + G   C A
Sbjct: 507 EVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQG--VAPE--DAGNYSCQA 562

Query: 502 SNDLGKNTSILFL 514
           +N++G +   + L
Sbjct: 563 TNEVGTDQETVTL 575



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 107/456 (23%), Positives = 168/456 (36%), Gaps = 72/456 (15%)

Query: 31  PAPELVEVEVGSTALLKCG-LSQSQGNLSHV-DWFSVHKEKRTLIFRVRQGQGQSEPGEY 88
           PAP  V V  G TA+L C  L ++  NL+ V DW       R L          +  G  
Sbjct: 405 PAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDW-------RVL---------PASTGRV 447

Query: 89  EQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRS-QEYRIQLRVYKAPEEPNIQVNPLG 147
            Q   L     +L ++ + P D   + C            + L V +AP     QV+   
Sbjct: 448 AQLADL-----SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAP-----QVSIHT 497

Query: 148 IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
              +  +  EV      +GYP P + W +  + L+E+ +R+H+ +  T+   G       
Sbjct: 498 SSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQED-SRIHVDAQGTLIIQG------- 549

Query: 208 LKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDR 267
               +  ED         NY   + N +   +E TV ++Y        V  V ++  G+ 
Sbjct: 550 ----VAPEDAG-------NYSCQATNEVGTDQE-TVTLYYTDPPSVSAVNAVVLVAVGEE 597

Query: 268 VEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDT 327
             + C A G PPP     +       A E ++  +G L +  A++  +G Y C+ ++   
Sbjct: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCRAVN--- 652

Query: 328 MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL- 386
            +   S   +L V +   +   P     + G S  L C A         W R + GQ L 
Sbjct: 653 ELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGD-GQPLG 711

Query: 387 ----------ERGP---VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWM 433
                      R P   VL    +  E    Y C A           +L+ V    PP +
Sbjct: 712 LRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLI-VTGHAPPQI 770

Query: 434 AFKERKVWVKENMVLNLSC-EASGHPRPTISWNVNG 468
           A     V V E   ++L C   +G P P   W  +G
Sbjct: 771 ASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG 806



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 91/407 (22%), Positives = 154/407 (37%), Gaps = 50/407 (12%)

Query: 149  PVNSKEPEEVATCVGRN--------GYPIPQVIWYK-NGRPLKEEKNRVHIQSSQTVESS 199
            P  ++ P +V   +GR+        G P P V W + +G+PL           S+  +S 
Sbjct: 669  PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728

Query: 200  GLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPV 259
             L+        + V  +  A + CE   R   G    E+R +      P         P 
Sbjct: 729  VLFF-------ESVAPEDQAPYVCEA--RNVFGKVQAEARLIVTGHAPPQIA---SSAPT 776

Query: 260  GMLKEGDRVEIRCLA-DGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRY 318
              + EG  V + C+   G P P     K           +   +G L L+ A +EH+GRY
Sbjct: 777  VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRY 836

Query: 319  ECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPER--QEGSSLTLTCEAESSQDLEFQ 376
             C   +     +  S+ +++ +      R+ P A      EG   +L C A         
Sbjct: 837  SCVATN-----TAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTIT 891

Query: 377  WLREETGQVLERGP--------VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIF 428
            W +E T  +  RGP         L +     +  G Y C A+  +  G + +Q + +++ 
Sbjct: 892  WTKE-TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT--NTVGFS-SQEMRLSVN 947

Query: 429  GPPWMAFKERK-------VWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL 481
              P +     +       V  K    + L CEA G P P ++W  +        +   +L
Sbjct: 948  TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLL 1007

Query: 482  STLNV-LVTPELLETG-VECTASNDLGKNTSILFLELVNLTTLTPDS 526
             + ++ L   ++ ++G  ECTASN  G  +    L +   T+  P S
Sbjct: 1008 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQS 1054


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 95/446 (21%), Positives = 164/446 (36%), Gaps = 63/446 (14%)

Query: 117 QGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYK 176
           QG R R +++            P I  +P  + V+  EP  +  C    G P P + WYK
Sbjct: 36  QGSRLRQEDF-----------PPRIVEHPSDVIVSKGEPTTL-NCKAE-GRPTPTIEWYK 82

Query: 177 NGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMK 236
           +G  ++ +K+    +S + +  SG      I+  +  K D+ +      NY    G  + 
Sbjct: 83  DGERVETDKDDP--RSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYL---GEAVS 137

Query: 237 ESREVTVPVFY------PTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPS 290
            +  + V +        PT+ V    EP  +  +  R        G+P P     K    
Sbjct: 138 RNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPR--------GHPEPTIYWKKDKVR 189

Query: 291 TREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSP 350
             + EE  +   G L++   RK  +G Y C G ++  +    S+P EL V         P
Sbjct: 190 IDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM--VGERDSDPAELTVFERPTFLRRP 247

Query: 351 AAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGP-------VLQLHDLKREAGG 403
                 E  ++   C+ +       +W +++    L RG         L++        G
Sbjct: 248 INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD--LPRGRYDIKDDYTLRIKKTMSTDEG 305

Query: 404 GYRCVASVPSIPGLNRTQLVNVA----IFGPPWMAFKERKVWVKENMVLNLSCEASGHPR 459
            Y C+A        NR   +  +    +  PP    + R   V +   +   CE  G+P+
Sbjct: 306 TYMCIAE-------NRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQ 358

Query: 460 PTISWNVNGTASEQ-DQDPQRVLSTLNVLVTPELLETGVE--------CTASNDLGKNTS 510
           P + W   G+ +      PQ+  S  +V  T +L  T ++        C A    G   +
Sbjct: 359 PAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILA 418

Query: 511 ILFLELVNLTTLTPDSNTTTGLSTST 536
              LE+ ++ T  P      G +  T
Sbjct: 419 KAQLEVTDVLTDRPPPIILQGPANQT 444



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 88/425 (20%), Positives = 153/425 (36%), Gaps = 55/425 (12%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE  ++C  +    +       +  A    + + NP  + V + EP  +  C    G+P 
Sbjct: 120 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA-ILECQPPRGHPE 178

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+   + +++ R+ I+  + + S+                  DA  Y  +   +
Sbjct: 179 PTIYWKKDKVRIDDKEERISIRGGKLMISN--------------TRKSDAGMYTCVGTNM 224

Query: 230 PSGNHMKESREVTV---PVFY--PTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSI 284
             G    +  E+TV   P F   P  +V LE E V         E RC   G+P P    
Sbjct: 225 V-GERDSDPAELTVFERPTFLRRPINQVVLEEEAV---------EFRCQVQGDPQPTVRW 274

Query: 285 SKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS 344
            K +        +  +D   L ++       G Y C     +  +  +     L V    
Sbjct: 275 KKDDADLPRGRYDIKDDY-TLRIKKTMSTDEGTYMCIA---ENRVGKMEASATLTVRAPP 330

Query: 345 DVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPV---- 391
              V P      +G ++T  CE + +      W +E +  +L          R  V    
Sbjct: 331 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 390

Query: 392 -LQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFG---PPWMAFKERKVWVKENMV 447
            L + +++R   G Y C A   +   L + QL    +     PP +        +  +  
Sbjct: 391 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 450

Query: 448 LNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPEL--LETGV-ECTASND 504
             L C+A+G P P ISW   G  +   +DP+  +     L    L   +TG   C A++ 
Sbjct: 451 ALLKCKATGDPLPVISWLKEG-FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 509

Query: 505 LGKNT 509
            G+ +
Sbjct: 510 SGETS 514


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 71/269 (26%), Positives = 112/269 (41%), Gaps = 38/269 (14%)

Query: 265 GDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGR------Y 318
           G  + + C  +G PP   +  K      E+   T   NG L++   R E  G       Y
Sbjct: 56  GQPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDY 115

Query: 319 ECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWL 378
           EC   +   ++  +S    +    +SD  V P A   +EG      C+          W 
Sbjct: 116 ECVAQNRFGLV--VSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWE 173

Query: 379 RE--------ETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGP 430
           +         E   +L +G VLQ+  L+ E GG + CVAS  +I  +  +    + + G 
Sbjct: 174 KNRVPIDTDNERYTLLPKG-VLQITGLRAEDGGIFHCVAS--NIASIRISHGARLTVSGS 230

Query: 431 PWMAFKERKVWV-KENMVLN------LSCEASGHPRPTISWNVNGTASEQDQDP-----Q 478
              A+KE  + V  EN+ L       L C A+G+PRP +SW      S  D  P      
Sbjct: 231 GSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSW------SRLDGRPIGVEGI 284

Query: 479 RVLSTLNVLVTPELLE-TGVECTASNDLG 506
           +VL T N++++   ++ +GV   A+N  G
Sbjct: 285 QVLGTGNLIISDVTVQHSGVYVCAANRPG 313



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 58/263 (22%), Positives = 98/263 (37%), Gaps = 41/263 (15%)

Query: 165 NGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCE 224
           +G P P + W KN  P+  +  R  +     ++ +GL            + +    F+C 
Sbjct: 163 HGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGL------------RAEDGGIFHCV 210

Query: 225 LN----YRLPSGNHMKESREVTVPVFYPT-----EKVWLEVEPVGMLKEGDRVEIRCLAD 275
            +     R+  G  +  S   +     P      E + L V    +L+        C+A 
Sbjct: 211 ASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLE--------CVAT 262

Query: 276 GNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEP 335
           GNP P  S S+ +      E       G L++     +HSG Y C      T +   ++ 
Sbjct: 263 GNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQG 322

Query: 336 QELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERG------ 389
           + L+V   ++    P +  R  G++   TC+A+        WL+   GQVL  G      
Sbjct: 323 R-LVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLK--NGQVLGPGGHVRLK 379

Query: 390 ---PVLQLHDLKREAGGGYRCVA 409
                L +  +  E    Y+CVA
Sbjct: 380 NNNSTLTISGIGPEDEAIYQCVA 402



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 53/221 (23%), Positives = 82/221 (37%), Gaps = 19/221 (8%)

Query: 263 KEGDRVEIRCLADGNPPPHFSISKQN-PSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
           +EG     +C   G P P  +  K   P   + E  T    GVL +   R E  G + C 
Sbjct: 151 EEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCV 210

Query: 322 GLDLDTMISLLSEPQELLVNYV-SDVRVSPAAPERQEGSSLT------LTCEAESSQDLE 374
             ++ ++   +S    L V+   S     PA     E  +LT      L C A  +    
Sbjct: 211 ASNIASI--RISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPI 268

Query: 375 FQWLR-------EETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAI 427
             W R        E  QVL  G ++ + D+  +  G Y C A+ P    + RT    + +
Sbjct: 269 VSWSRLDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVCAANRPGTR-VRRTAQGRLVV 326

Query: 428 FGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNG 468
             P       + +          +C+A G P P ++W  NG
Sbjct: 327 QAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNG 367



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 6/83 (7%)

Query: 101 LALTQVTPQDERIFLCQGKRPRSQEYRIQ--LRVYKAPEEPNIQVNPLGIPVNSKEPEEV 158
           L ++ VT Q   +++C   RP ++  R      V +AP E       +  P  +     +
Sbjct: 292 LIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT---TAM 348

Query: 159 ATCVGRNGYPIPQVIWYKNGRPL 181
            TC  + G P P V W KNG+ L
Sbjct: 349 FTCQAQ-GEPPPHVTWLKNGQVL 370


>gi|18201909 vascular cell adhesion molecule 1 isoform b precursor
           [Homo sapiens]
          Length = 647

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 105/453 (23%), Positives = 177/453 (39%), Gaps = 77/453 (16%)

Query: 99  ATLALTQVTPQDERIFLCQGK-RPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
           +TL +  V+  +E  +LC      R  E  IQ+ +Y  P++P I ++    P+ + +P  
Sbjct: 78  STLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSG---PLEAGKPIT 134

Query: 158 VATCVGRNGYPIPQV-IWYKNGRPLKEEKNRVHIQSSQTVESSGL-YTLQSILKAQLVKE 215
           V  C   + YP  ++ I    G  L + +  +     +++E+  L  T   ++      E
Sbjct: 135 VK-CSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVI------E 187

Query: 216 DKDAQFYCELNYRLPSGNHMKESREVT--VPVFYPTEKVWLEVEPVGMLKEGDRVEIRCL 273
           D      C     +   + +   R+    + V+   +   + V P   L+EG  V + C 
Sbjct: 188 DIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCS 247

Query: 274 ADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLS 333
           ++G P P    SK+         +  + N  L L   R E SG Y C+G++L   I    
Sbjct: 248 SEGLPAPEIFWSKK---LDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNL---IGKNR 301

Query: 334 EPQELLVNYVSDVRVSPAAPERQ------EGSSLTLTCEAES---SQDLEFQWLREETGQ 384
           +  EL+      V+  P  PE +       GSS+T++C+  S      LE + L+ ET  
Sbjct: 302 KEVELI------VQAFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGET-- 353

Query: 385 VLERGPVLQLHDLK---------------REAGGGYRCVASV--------PSIPGLNRTQ 421
           +LE    L+  D+K                + G    C A +        P      +T 
Sbjct: 354 ILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTL 413

Query: 422 LVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVL 481
            VNVA               ++E   +N++C + G P P I W+         Q P   L
Sbjct: 414 YVNVA--PRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWS--------RQLPNGEL 463

Query: 482 STLNVLVTPELLETGVE------CTASNDLGKN 508
             L+   T  L+ T +E      C   N  G++
Sbjct: 464 QPLSENATLTLISTKMEDSGVYLCEGINQAGRS 496



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/276 (22%), Positives = 125/276 (45%), Gaps = 27/276 (9%)

Query: 99  ATLALTQVTPQDERIFLCQGKRPRSQEYR-IQLRVYKAPEEPNIQVNPLGIPVNSKEPEE 157
           ATL L  +  +D  I++C+G     +  + ++L V   P +P I+++  G  VN      
Sbjct: 274 ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQAFPRDPEIEMS--GGLVNGSSV-- 329

Query: 158 VATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQS-ILKAQLVK-- 214
             +C   + YP+ ++        ++  K    +++ + +E + + +L++  L+   +   
Sbjct: 330 TVSCKVPSVYPLDRL-------EIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTI 382

Query: 215 EDKDAQFYCELNYRLPSGNHMKESREVTVPVFY---PTEKVWLEVEPVGMLKEGDRVEIR 271
           ED      C+    +       + R+ T  ++    P +   L V P  +L+EG  V + 
Sbjct: 383 EDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVL-VSPSSILEEGSSVNMT 441

Query: 272 CLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISL 331
           CL+ G P P    S+Q P+    E +  ++N  L L   + E SG Y C+G++       
Sbjct: 442 CLSQGFPAPKILWSRQLPN---GELQPLSENATLTLISTKMEDSGVYLCEGIN---QAGR 495

Query: 332 LSEPQELLVNYV-SDVRVSPAAPER-QEGSSLTLTC 365
             +  EL++     D++++    E  +EG ++ ++C
Sbjct: 496 SRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISC 531



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 52/240 (21%), Positives = 94/240 (39%), Gaps = 41/240 (17%)

Query: 93  SLQDRGATLALTQVTPQDERIFLCQGK--------RPRSQEYRIQLRVYKAPEEPNIQVN 144
           SL+++   +          +  +CQ K         P+ ++    L V  AP +  + V+
Sbjct: 368 SLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVS 427

Query: 145 PLGIPVNSKEPEEVATCVGRNGYPIPQVIWYK---NGRPLKEEKNRVHIQSSQTVESSGL 201
           P  I           TC+ + G+P P+++W +   NG      +N      S  +E SG+
Sbjct: 428 PSSILEEGSSVN--MTCLSQ-GFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGV 484

Query: 202 YTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGM 261
           Y  + I +A                         +  +EV + +    + + L   P   
Sbjct: 485 YLCEGINQAG------------------------RSRKEVELIIQVTPKDIKLTAFPSES 520

Query: 262 LKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQ 321
           +KEGD V I C   GN P  + I K+   T +   ++   +G   +  A+ + +G YEC+
Sbjct: 521 VKEGDTVIISCTC-GNVPETWIILKKKAETGDTVLKSI--DGAYTIRKAQLKDAGVYECE 577


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 91/424 (21%), Positives = 157/424 (37%), Gaps = 52/424 (12%)

Query: 139 PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES 198
           P I  +P  + V+  EP  +  C    G P P + WYK+G  ++ +K+    +S + +  
Sbjct: 31  PRIVEHPSDVIVSKGEPTTL-NCKAE-GRPTPTIEWYKDGERVETDKDDP--RSHRMLLP 86

Query: 199 SGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFY------PTEKV 252
           SG      I+  +  K D+ +      NY    G  +  +  + V +        PT+ V
Sbjct: 87  SGSLFFLRIVHGRRSKPDEGSYVCVARNYL---GEAVSRNASLEVALLRDDFRQNPTDVV 143

Query: 253 WLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARK 312
               EP  +  +  R        G+P P     K      + EE  +   G L++   RK
Sbjct: 144 VAAGEPAILECQPPR--------GHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRK 195

Query: 313 EHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQD 372
             +G Y C G ++  +    S+P EL V         P      E  ++   C+ +    
Sbjct: 196 SDAGMYTCVGTNM--VGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253

Query: 373 LEFQWLREETGQVLERGP-------VLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNV 425
              +W +++    L RG         L++        G Y C+A        NR   +  
Sbjct: 254 PTVRWKKDDAD--LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAE-------NRVGKMEA 304

Query: 426 A----IFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQ-DQDPQRV 480
           +    +  PP    + R   V +   +   CE  G+P+P + W   G+ +      PQ+ 
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364

Query: 481 LSTLNVLVTPELLETGVE--------CTASNDLGKNTSILFLELVNLTTLTPDSNTTTGL 532
            S  +V  T +L  T ++        C A    G   +   LE+ ++ T  P      G 
Sbjct: 365 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424

Query: 533 STST 536
           +  T
Sbjct: 425 ANQT 428



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 88/425 (20%), Positives = 153/425 (36%), Gaps = 55/425 (12%)

Query: 110 DERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPI 169
           DE  ++C  +    +       +  A    + + NP  + V + EP  +  C    G+P 
Sbjct: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA-ILECQPPRGHPE 162

Query: 170 PQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRL 229
           P + W K+   + +++ R+ I+  + + S+                  DA  Y  +   +
Sbjct: 163 PTIYWKKDKVRIDDKEERISIRGGKLMISN--------------TRKSDAGMYTCVGTNM 208

Query: 230 PSGNHMKESREVTV---PVFY--PTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSI 284
             G    +  E+TV   P F   P  +V LE E V         E RC   G+P P    
Sbjct: 209 V-GERDSDPAELTVFERPTFLRRPINQVVLEEEAV---------EFRCQVQGDPQPTVRW 258

Query: 285 SKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVS 344
            K +        +  +D   L ++       G Y C     +  +  +     L V    
Sbjct: 259 KKDDADLPRGRYDIKDDY-TLRIKKTMSTDEGTYMCIA---ENRVGKMEASATLTVRAPP 314

Query: 345 DVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVL---------ERGPV---- 391
              V P      +G ++T  CE + +      W +E +  +L          R  V    
Sbjct: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 374

Query: 392 -LQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFG---PPWMAFKERKVWVKENMV 447
            L + +++R   G Y C A   +   L + QL    +     PP +        +  +  
Sbjct: 375 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434

Query: 448 LNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPEL--LETGV-ECTASND 504
             L C+A+G P P ISW   G  +   +DP+  +     L    L   +TG   C A++ 
Sbjct: 435 ALLKCKATGDPLPVISWLKEG-FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSS 493

Query: 505 LGKNT 509
            G+ +
Sbjct: 494 SGETS 498



 Score = 36.6 bits (83), Expect = 0.074
 Identities = 18/50 (36%), Positives = 24/50 (48%)

Query: 430 PPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQR 479
           PP +      V V +     L+C+A G P PTI W  +G   E D+D  R
Sbjct: 30  PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPR 79


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,768,612
Number of Sequences: 37866
Number of extensions: 1381285
Number of successful extensions: 6836
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 231
Number of HSP's that attempted gapping in prelim test: 3875
Number of HSP's gapped (non-prelim): 2087
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.