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Search of human proteins with 71164888
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
(424 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens] 880 0.0
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens] 857 0.0
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 208 9e-54
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 192 4e-49
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 184 2e-46
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 147 2e-35
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 86 8e-17
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 83 5e-16
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 82 1e-15
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 82 1e-15
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 82 1e-15
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 82 1e-15
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 77 3e-14
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 77 3e-14
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 76 7e-14
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 76 7e-14
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 71 2e-12
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 67 4e-11
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 64 2e-10
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 56 7e-08
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 51 2e-06
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 48 2e-05
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 47 3e-05
gi|32483399 p21-activated kinase 2 [Homo sapiens] 46 6e-05
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 46 7e-05
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 46 7e-05
gi|115298645 mitogen-activated protein kinase kinase kinase 14 [... 45 1e-04
>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
Length = 424
Score = 880 bits (2274), Expect = 0.0
Identities = 424/424 (100%), Positives = 424/424 (100%)
Query: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQ 60
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQ
Sbjct: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSGSRPPTPKSSPQ 60
Query: 61 KTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKS 120
KTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKS
Sbjct: 61 KTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKS 120
Query: 121 FQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKW 180
FQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKW
Sbjct: 121 FQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKW 180
Query: 181 KKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRL 240
KKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRL
Sbjct: 181 KKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRL 240
Query: 241 LDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPH 300
LDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPH
Sbjct: 241 LDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPH 300
Query: 301 EGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDK 360
EGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDK
Sbjct: 301 EGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDK 360
Query: 361 PGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGL 420
PGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGL
Sbjct: 361 PGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGL 420
Query: 421 PMVP 424
PMVP
Sbjct: 421 PMVP 424
>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
Length = 474
Score = 857 bits (2213), Expect = 0.0
Identities = 424/474 (89%), Positives = 424/474 (89%), Gaps = 50/474 (10%)
Query: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQ-------------- 46
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQ
Sbjct: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSP 60
Query: 47 ------------------------------------GSGSRPPTPKSSPQKTRKSPQVTR 70
GSGSRPPTPKSSPQKTRKSPQVTR
Sbjct: 61 KKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTR 120
Query: 71 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 130
GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
Sbjct: 121 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 180
Query: 131 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 190
YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA
Sbjct: 181 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 240
Query: 191 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 250
IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN
Sbjct: 241 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 300
Query: 251 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 310
EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD
Sbjct: 301 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 360
Query: 311 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 370
LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH
Sbjct: 361 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 420
Query: 371 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 424
WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP
Sbjct: 421 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 208 bits (529), Expect = 9e-54
Identities = 114/316 (36%), Positives = 173/316 (54%), Gaps = 11/316 (3%)
Query: 100 EALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD- 158
E G ++TD + ++WK+ + G +Y A S+ +S +K++ D
Sbjct: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSS---ESVGSDAPCVVKVEPSDN 77
Query: 159 GRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRS 215
G LF E F+QRAAKP Q+ KW + L +P G G+H YRF+++ G
Sbjct: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137
Query: 216 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA 275
LQ + + K S ++VLQ++ R+LD LE++HE+EYVHG++ A N+ ++ ++ QV L
Sbjct: 138 LQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196
Query: 276 GYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 335
YG A+RYCP G H Y E + H+G +EF S+D H G PSRR DL+ LGYCM++WL
Sbjct: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256
Query: 336 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPP 395
G LPW + L + + + K ++ + + C + KY++ V L Y EKP
Sbjct: 257 GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316
Query: 396 YAMLRNNLEALLQDLR 411
Y LR + LLQ L+
Sbjct: 317 YENLR---DILLQGLK 329
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 103 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 160
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 161 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 217
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 398 MLRNNLEALLQDLRVSPYDPIGLPMVP 424
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 184 bits (466), Expect = 2e-46
Identities = 113/317 (35%), Positives = 164/317 (51%), Gaps = 25/317 (7%)
Query: 113 GRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GRLFNEQNFFQR 170
G QW L G++Y A PT+ P+K + +K++ ++ G LF+E F+QR
Sbjct: 3 GNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGPLFSELKFYQR 56
Query: 171 AAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQSALDVSPKHV 227
AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 57 VAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKIS--GQNGT 114
Query: 228 LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSG 287
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA YG ++RYCP+G
Sbjct: 115 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 174
Query: 288 KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT 347
H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G LPW L +
Sbjct: 175 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 234
Query: 348 EDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALL 407
+ K +D+ V + ++L +L Y+EKP Y L+ L
Sbjct: 235 VAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKIL---- 290
Query: 408 QDLRVSPYDPIGLPMVP 424
+P G+P+ P
Sbjct: 291 --------NPHGIPLGP 299
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 147 bits (371), Expect = 2e-35
Identities = 81/218 (37%), Positives = 116/218 (53%), Gaps = 14/218 (6%)
Query: 207 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 266
+V+ LG LQ + +VLQ+ R+LD LE++HENEYVHG++ A N+ +
Sbjct: 1 MVMERLGIDLQKIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
Query: 267 EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSL 326
++ QV LA YG ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ L
Sbjct: 59 KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
Query: 327 GYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVM 386
GYCML+WL G LPW L + + K +D+ V + ++L
Sbjct: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
Query: 387 ALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 424
+L Y+EKP Y L+ L +P G+P+ P
Sbjct: 179 SLAYDEKPNYQALKKIL------------NPHGIPLGP 204
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 8e-17
Identities = 63/228 (27%), Positives = 106/228 (46%), Gaps = 14/228 (6%)
Query: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262
KY +VL LG SL+ D+ + + ++VL +A +LL +E++H ++ +V EN
Sbjct: 112 KYNAMVLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENF 170
Query: 263 FVDPEDQSQ---VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317
+ + + + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 171 LIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 228
Query: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377
SRR DL++LG+ + +L G LPW +T QK + P C ++ E
Sbjct: 229 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENF---PEE 285
Query: 378 LQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVS---PYDPIGLPM 422
+ YL+ V L + EKP Y LR L + + YD +G P+
Sbjct: 286 MATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPI 333
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 82.8 bits (203), Expect = 5e-16
Identities = 66/231 (28%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 175 LQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVL 234
L+ +K+L +T +P FG KY +VL LG SL+ D+ + + ++VL
Sbjct: 88 LEYRFYKQLSATE--GVPQVYYFGPC-GKYNAMVLELLGPSLEDLFDLCDR-TFTLKTVL 143
Query: 235 QVACRLLDALEFLHENEYVHGNVTAENIFVD---PEDQSQVTLAGYGFAFRYCP--SGKH 289
+A +L+ +E++H ++ +V EN V + Q + + +G A Y + KH
Sbjct: 144 MIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKH 203
Query: 290 VAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTED 349
+ Y E G ++S++ H G SRR DL++LG+ + +L G LPW +T
Sbjct: 204 IPYRE--HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLK 261
Query: 350 IMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 400
QK + P C ++ E + YL+ V L + EKP Y LR
Sbjct: 262 ERYQKIGDTKRATPIEVLCENF---PEEMATYLRYVRRLDFFEKPDYDYLR 309
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 263 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 378 LQKYLKVVMALTYEEKPPYAMLR 400
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 263 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 378 LQKYLKVVMALTYEEKPPYAMLR 400
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 263 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 378 LQKYLKVVMALTYEEKPPYAMLR 400
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 203 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 262
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 263 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 317
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 318 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 377
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 378 LQKYLKVVMALTYEEKPPYAMLR 400
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IPT G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPTIRWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 249 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 305
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 400
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FATYLNFCRSLRFDDKPDYSYLR 270
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IPT G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPTIRWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 249 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 305
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 400
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FATYLNFCRSLRFDDKPDYSYLR 270
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 75.9 bits (185), Expect = 7e-14
Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IP+ G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPSIKWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 249 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 305
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 400
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FSTYLNFCRSLRFDDKPDYSYLR 270
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 75.9 bits (185), Expect = 7e-14
Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IP+ G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPSIKWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 249 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 305
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 400
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FSTYLNFCRSLRFDDKPDYSYLR 270
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 10/225 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 249 ENEYVHGNVTAENIFVD-PEDQSQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 305
++H ++ +N + +++ L +G A +Y + +H+ Y E G
Sbjct: 129 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTAR 186
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR D++SLGY ++ + LPW T+ +K P
Sbjct: 187 YASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVE 246
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 410
C + P+E YL L +EE P Y LR L + L
Sbjct: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTL 288
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 66.6 bits (161), Expect = 4e-11
Identities = 56/225 (24%), Positives = 101/225 (44%), Gaps = 10/225 (4%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IP +G +D LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHMHWYGQEKDN-NVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 249 ENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 305
++H ++ +N + +++ L +G A +Y + +H+ Y E G +
Sbjct: 129 TKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLI--GTVR 186
Query: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
+ S++ H G SRR D++SLGY + + LPW T+ +K P
Sbjct: 187 YASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVE 246
Query: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 410
C + P+E YL L +EE P Y LR L + L
Sbjct: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTL 288
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 64.3 bits (155), Expect = 2e-10
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 38/253 (15%)
Query: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 249 ENEYVHGNVTAENIFV---------------------------DPEDQ--SQVTLAGYGF 279
++H ++ +N + DP +Q+ L +G
Sbjct: 129 TKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGL 188
Query: 280 AFRYCPSG--KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 337
A +Y + +H+ Y E G + S++ H G SRR D++SLGY ++ +
Sbjct: 189 AKKYRDNRTRQHIPYREDKNLT--GTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS 246
Query: 338 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 397
LPW T+ +K P C + P+E YL L +EE P Y
Sbjct: 247 LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGF--PAE-FAMYLNYCRGLRFEEAPDYM 303
Query: 398 MLRNNLEALLQDL 410
LR L + L
Sbjct: 304 YLRQLFRILFRTL 316
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 55.8 bits (133), Expect = 7e-08
Identities = 48/213 (22%), Positives = 98/213 (46%), Gaps = 18/213 (8%)
Query: 202 DKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAEN 261
+K+ ++V+ GR+L P+ + + L++ ++L+++E +H ++H ++ N
Sbjct: 100 EKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSN 159
Query: 262 IFVD--PEDQSQVTLAGYGFAFRYCPSGKHVA---YVEGSRSPHEGDLEFISMDLHKGCG 316
+ P + + +G A +Y + V V G R G + + S++ HK
Sbjct: 160 FAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR----GTVRYASVNAHKNRE 215
Query: 317 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSE 376
R DL SL Y ++++ G LPW + + E + K+K+ + H PSE
Sbjct: 216 MGRHDDLWSLFYMLVEFAVGQLPWRK-IKDKEQVGMIKEKYEHRM-----LLKH--MPSE 267
Query: 377 TLQKYLKVVMALTYEEKPPYAMLRNNLEALLQD 409
+L + +L Y KP Y ++ + E +++
Sbjct: 268 -FHLFLDHIASLDYFTKPDYQLIMSVFENSMKE 299
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/225 (20%), Positives = 99/225 (44%), Gaps = 26/225 (11%)
Query: 202 DKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAEN 261
D++ ++V+ GR+L + + + L++ ++L+++E +H ++H ++ N
Sbjct: 87 DRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSN 146
Query: 262 IFVD--PEDQSQVTLAGYGFAFRY---CPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG 316
+ P + + +G A ++ C + V G R G + + S++ H+
Sbjct: 147 FAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFR----GTVRYASINAHRNRE 202
Query: 317 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIR--- 373
R DL SL Y +++++ G LPW + + E + K+++ H +
Sbjct: 203 MGRHDDLWSLFYMLVEFVVGQLPWRK-IKDKEQVGSIKERY-----------DHRLMLKH 250
Query: 374 -PSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDP 417
P E +L + +L Y KP Y +L + + ++ V DP
Sbjct: 251 LPPE-FSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDP 294
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 47.8 bits (112), Expect = 2e-05
Identities = 37/120 (30%), Positives = 60/120 (50%), Gaps = 6/120 (5%)
Query: 222 VSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAF 281
++ K LSE+ + LL+A+ FLH N VH ++ ENI +D D Q+ L+ +GF+
Sbjct: 119 LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD--DNMQIRLSDFGFSC 176
Query: 282 RYCPSGKHVAYVEGSRSPHEGDLEFISMD-LHKGCGPSRRSDLQSLGYCMLKWLYGFLPW 340
P G+ + + G+ ++ SMD H G G + DL + G + L G P+
Sbjct: 177 HLEP-GEKLRELCGTPGYLAPEILKCSMDETHPGYG--KEVDLWACGVILFTLLAGSPPF 233
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 223 SPKHVLS------ERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAG 276
S H+LS E V+ +LL L +LHEN+ +H +V N+ +D Q ++ +A
Sbjct: 1330 SVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQ-RLRIAD 1388
Query: 277 YGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYG 336
+G A R G +G G + F++ ++ +G R D+ S+G +++
Sbjct: 1389 FGAAARLASKGTGAGEFQGQLL---GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACA 1445
Query: 337 FLPW 340
PW
Sbjct: 1446 KPPW 1449
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
S DV + + E + V L ALEFLH N+ +H ++ ++N+ + E V L +
Sbjct: 330 SLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGME--GSVKLTDF 387
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 335
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 388 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMVE 438
Query: 336 GFLPWTN 342
G P+ N
Sbjct: 439 GEPPYLN 445
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
S DV + + E + V L ALEFLH N+ +H ++ ++NI + + V L +
Sbjct: 351 SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMD--GSVKLTDF 408
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 335
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 409 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMIE 459
Query: 336 GFLPWTN 342
G P+ N
Sbjct: 460 GEPPYLN 466
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 45.8 bits (107), Expect = 7e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 218 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 277
S DV + + E + V L ALEFLH N+ +H ++ ++NI + + V L +
Sbjct: 351 SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMD--GSVKLTDF 408
Query: 278 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 335
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 409 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMIE 459
Query: 336 GFLPWTN 342
G P+ N
Sbjct: 460 GEPPYLN 466
>gi|115298645 mitogen-activated protein kinase kinase kinase 14
[Homo sapiens]
Length = 947
Score = 45.1 bits (105), Expect = 1e-04
Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 3/120 (2%)
Query: 222 VSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAF 281
V + L E L + L+ LE+LH +HG+V A+N+ + D S L +G A
Sbjct: 481 VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLS-SDGSHAALCDFGHAV 539
Query: 282 RYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWT 341
P G + + G P G ++ ++ G + D+ S ML L G PWT
Sbjct: 540 CLQPDGLGKSLLTGDYIP--GTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWT 597
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,434,052
Number of Sequences: 37866
Number of extensions: 908534
Number of successful extensions: 4784
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 4126
Number of HSP's gapped (non-prelim): 798
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.