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Search of human proteins with 71164886
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
(474 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens] 975 0.0
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens] 857 0.0
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 208 1e-53
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 192 4e-49
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 192 4e-49
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 184 2e-46
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 147 2e-35
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 86 1e-16
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 83 6e-16
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 82 1e-15
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 82 1e-15
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 82 1e-15
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 82 1e-15
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 77 3e-14
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 77 3e-14
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 76 8e-14
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 76 8e-14
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 71 2e-12
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 67 5e-11
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 64 2e-10
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 56 8e-08
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 51 2e-06
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 48 2e-05
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 47 4e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 47 5e-05
gi|32483399 p21-activated kinase 2 [Homo sapiens] 46 6e-05
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 46 8e-05
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 46 8e-05
>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
Length = 474
Score = 975 bits (2521), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSP 60
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSP
Sbjct: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSP 60
Query: 61 KKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTR 120
KKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTR
Sbjct: 61 KKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTR 120
Query: 121 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 180
GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
Sbjct: 121 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 180
Query: 181 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 240
YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA
Sbjct: 181 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 240
Query: 241 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 300
IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN
Sbjct: 241 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 300
Query: 301 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 360
EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD
Sbjct: 301 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 360
Query: 361 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 420
LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH
Sbjct: 361 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 420
Query: 421 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474
WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP
Sbjct: 421 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474
>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
Length = 424
Score = 857 bits (2213), Expect = 0.0
Identities = 424/474 (89%), Positives = 424/474 (89%), Gaps = 50/474 (10%)
Query: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSP 60
MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQ
Sbjct: 1 MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQ-------------- 46
Query: 61 KKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTR 120
GSGSRPPTPKSSPQKTRKSPQVTR
Sbjct: 47 ------------------------------------GSGSRPPTPKSSPQKTRKSPQVTR 70
Query: 121 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 180
GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL
Sbjct: 71 GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGIL 130
Query: 181 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 240
YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA
Sbjct: 131 YEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLA 190
Query: 241 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 300
IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN
Sbjct: 191 IPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHEN 250
Query: 301 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 360
EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD
Sbjct: 251 EYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD 310
Query: 361 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 420
LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH
Sbjct: 311 LHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGH 370
Query: 421 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474
WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP
Sbjct: 371 WIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 424
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 208 bits (529), Expect = 1e-53
Identities = 114/316 (36%), Positives = 173/316 (54%), Gaps = 11/316 (3%)
Query: 150 EALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKD- 208
E G ++TD + ++WK+ + G +Y A S+ +S +K++ D
Sbjct: 21 EQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSS---ESVGSDAPCVVKVEPSDN 77
Query: 209 GRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRS 265
G LF E F+QRAAKP Q+ KW + L +P G G+H YRF+++ G
Sbjct: 78 GPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSD 137
Query: 266 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA 325
LQ + + K S ++VLQ++ R+LD LE++HE+EYVHG++ A N+ ++ ++ QV L
Sbjct: 138 LQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLV 196
Query: 326 GYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLY 385
YG A+RYCP G H Y E + H+G +EF S+D H G PSRR DL+ LGYCM++WL
Sbjct: 197 DYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT 256
Query: 386 GFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPP 445
G LPW + L + + + K ++ + + C + KY++ V L Y EKP
Sbjct: 257 GHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPL 316
Query: 446 YAMLRNNLEALLQDLR 461
Y LR + LLQ L+
Sbjct: 317 YENLR---DILLQGLK 329
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 192 bits (489), Expect = 4e-49
Identities = 118/327 (36%), Positives = 169/327 (51%), Gaps = 25/327 (7%)
Query: 153 PTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GR 210
P G VL D G QW L G++Y A PT+ P+K + +K++ ++ G
Sbjct: 16 PEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGP 69
Query: 211 LFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQ 267
LF+E F+QR AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 70 LFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQ 129
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA Y
Sbjct: 130 KIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADY 187
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
G ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G
Sbjct: 188 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 247
Query: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
LPW L + + K +D+ V + ++L +L Y+EKP Y
Sbjct: 248 LPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQ 307
Query: 448 MLRNNLEALLQDLRVSPYDPIGLPMVP 474
L+ L +P G+P+ P
Sbjct: 308 ALKKIL------------NPHGIPLGP 322
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 184 bits (466), Expect = 2e-46
Identities = 113/317 (35%), Positives = 164/317 (51%), Gaps = 25/317 (7%)
Query: 163 GRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQ-KFSLKLDAKD-GRLFNEQNFFQR 220
G QW L G++Y A PT+ P+K + +K++ ++ G LF+E F+QR
Sbjct: 3 GNQWVLGKKIGSGGFGLIYLAFPTNK------PEKDARHVVKVEYQENGPLFSELKFYQR 56
Query: 221 AAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDK---YRFLVLPSLGRSLQSALDVSPKHV 277
AK + KW + L IP G G+ + K YRF+V+ LG LQ
Sbjct: 57 VAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKIS--GQNGT 114
Query: 278 LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSG 337
+ +VLQ+ R+LD LE++HENEYVHG++ A N+ + ++ QV LA YG ++RYCP+G
Sbjct: 115 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 174
Query: 338 KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT 397
H Y E R H G +EF S+D HKG SRRSD++ LGYCML+WL G LPW L +
Sbjct: 175 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDP 234
Query: 398 EDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALL 457
+ K +D+ V + ++L +L Y+EKP Y L+ L
Sbjct: 235 VAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKIL---- 290
Query: 458 QDLRVSPYDPIGLPMVP 474
+P G+P+ P
Sbjct: 291 --------NPHGIPLGP 299
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 147 bits (371), Expect = 2e-35
Identities = 81/218 (37%), Positives = 116/218 (53%), Gaps = 14/218 (6%)
Query: 257 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 316
+V+ LG LQ + +VLQ+ R+LD LE++HENEYVHG++ A N+ +
Sbjct: 1 MVMERLGIDLQKIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
Query: 317 EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSL 376
++ QV LA YG ++RYCP+G H Y E R H G +EF S+D HKG SRRSD++ L
Sbjct: 59 KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
Query: 377 GYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVM 436
GYCML+WL G LPW L + + K +D+ V + ++L
Sbjct: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
Query: 437 ALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474
+L Y+EKP Y L+ L +P G+P+ P
Sbjct: 179 SLAYDEKPNYQALKKIL------------NPHGIPLGP 204
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 85.5 bits (210), Expect = 1e-16
Identities = 63/228 (27%), Positives = 106/228 (46%), Gaps = 14/228 (6%)
Query: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312
KY +VL LG SL+ D+ + + ++VL +A +LL +E++H ++ +V EN
Sbjct: 112 KYNAMVLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENF 170
Query: 313 FVDPEDQSQ---VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367
+ + + + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 171 LIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 228
Query: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427
SRR DL++LG+ + +L G LPW +T QK + P C ++ E
Sbjct: 229 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENF---PEE 285
Query: 428 LQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVS---PYDPIGLPM 472
+ YL+ V L + EKP Y LR L + + YD +G P+
Sbjct: 286 MATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPI 333
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 82.8 bits (203), Expect = 6e-16
Identities = 66/231 (28%), Positives = 109/231 (47%), Gaps = 14/231 (6%)
Query: 225 LQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVL 284
L+ +K+L +T +P FG KY +VL LG SL+ D+ + + ++VL
Sbjct: 88 LEYRFYKQLSATE--GVPQVYYFGPC-GKYNAMVLELLGPSLEDLFDLCDR-TFTLKTVL 143
Query: 285 QVACRLLDALEFLHENEYVHGNVTAENIFVD---PEDQSQVTLAGYGFAFRYCP--SGKH 339
+A +L+ +E++H ++ +V EN V + Q + + +G A Y + KH
Sbjct: 144 MIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKH 203
Query: 340 VAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTED 399
+ Y E G ++S++ H G SRR DL++LG+ + +L G LPW +T
Sbjct: 204 IPYRE--HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLK 261
Query: 400 IMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
QK + P C ++ E + YL+ V L + EKP Y LR
Sbjct: 262 ERYQKIGDTKRATPIEVLCENF---PEEMATYLRYVRRLDFFEKPDYDYLR 309
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 313 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 428 LQKYLKVVMALTYEEKPPYAMLR 450
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 313 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 428 LQKYLKVVMALTYEEKPPYAMLR 450
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 313 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 428 LQKYLKVVMALTYEEKPPYAMLR 450
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 81.6 bits (200), Expect = 1e-15
Identities = 59/203 (29%), Positives = 99/203 (48%), Gaps = 12/203 (5%)
Query: 253 KYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENI 312
KY +VL LG SL+ D+ + S ++VL +A +L+ +E++H ++ +V EN
Sbjct: 110 KYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENF 168
Query: 313 FVD-PEDQSQ--VTLAGYGFAFRYCP--SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 367
+ P +++Q + + +G A Y + KH+ Y E G ++S++ H G
Sbjct: 169 LIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYRE--HKSLTGTARYMSINTHLGKEQ 226
Query: 368 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSET 427
SRR DL++LG+ + +L G LPW +T QK + P C ++
Sbjct: 227 SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF----PE 282
Query: 428 LQKYLKVVMALTYEEKPPYAMLR 450
+ YL+ V L + EKP Y LR
Sbjct: 283 MATYLRYVRRLDFFEKPDYDYLR 305
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IPT G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPTIRWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 299 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 355
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FATYLNFCRSLRFDDKPDYSYLR 270
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IPT G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPTIRWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 299 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 355
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FATYLNFCRSLRFDDKPDYSYLR 270
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 75.9 bits (185), Expect = 8e-14
Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IP+ G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPSIKWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 299 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 355
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FSTYLNFCRSLRFDDKPDYSYLR 270
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 75.9 bits (185), Expect = 8e-14
Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 10/215 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IP+ G D Y +V+ LG SL+ + + S ++VL +A +++ +E++H
Sbjct: 63 VGIPSIKWCGAEGD-YNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIH 120
Query: 299 ENEYVHGNVTAENIFVDPEDQSQ-VTLAGYGFAFRY--CPSGKHVAYVEGSRSPHEGDLE 355
++H +V +N + + V + +G A +Y + +H+ Y E G
Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT--GTAR 178
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR DL+SLGY ++ + G LPW T+ ++ P
Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIE 238
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLR 450
C + PSE YL +L +++KP Y+ LR
Sbjct: 239 VLCKGY--PSE-FSTYLNFCRSLRFDDKPDYSYLR 270
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 10/225 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 299 ENEYVHGNVTAENIFVD-PEDQSQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 355
++H ++ +N + +++ L +G A +Y + +H+ Y E G
Sbjct: 129 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT--GTAR 186
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR D++SLGY ++ + LPW T+ +K P
Sbjct: 187 YASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVE 246
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 460
C + P+E YL L +EE P Y LR L + L
Sbjct: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTL 288
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 66.6 bits (161), Expect = 5e-11
Identities = 56/225 (24%), Positives = 101/225 (44%), Gaps = 10/225 (4%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IP +G +D LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHMHWYGQEKDN-NVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 299 ENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 355
++H ++ +N + +++ L +G A +Y + +H+ Y E G +
Sbjct: 129 TKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLI--GTVR 186
Query: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
+ S++ H G SRR D++SLGY + + LPW T+ +K P
Sbjct: 187 YASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVE 246
Query: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 460
C + P+E YL L +EE P Y LR L + L
Sbjct: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTL 288
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 64.3 bits (155), Expect = 2e-10
Identities = 60/253 (23%), Positives = 104/253 (41%), Gaps = 38/253 (15%)
Query: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
+ IP +G +D Y LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 71 VGIPHIRWYGQEKD-YNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
Query: 299 ENEYVHGNVTAENIFV---------------------------DPEDQ--SQVTLAGYGF 329
++H ++ +N + DP +Q+ L +G
Sbjct: 129 TKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGL 188
Query: 330 AFRYCPSG--KHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGF 387
A +Y + +H+ Y E G + S++ H G SRR D++SLGY ++ +
Sbjct: 189 AKKYRDNRTRQHIPYREDKNLT--GTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS 246
Query: 388 LPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYA 447
LPW T+ +K P C + P+E YL L +EE P Y
Sbjct: 247 LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGF--PAE-FAMYLNYCRGLRFEEAPDYM 303
Query: 448 MLRNNLEALLQDL 460
LR L + L
Sbjct: 304 YLRQLFRILFRTL 316
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 55.8 bits (133), Expect = 8e-08
Identities = 48/213 (22%), Positives = 98/213 (46%), Gaps = 18/213 (8%)
Query: 252 DKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAEN 311
+K+ ++V+ GR+L P+ + + L++ ++L+++E +H ++H ++ N
Sbjct: 100 EKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSN 159
Query: 312 IFVD--PEDQSQVTLAGYGFAFRYCPSGKHVA---YVEGSRSPHEGDLEFISMDLHKGCG 366
+ P + + +G A +Y + V V G R G + + S++ HK
Sbjct: 160 FAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR----GTVRYASVNAHKNRE 215
Query: 367 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSE 426
R DL SL Y ++++ G LPW + + E + K+K+ + H PSE
Sbjct: 216 MGRHDDLWSLFYMLVEFAVGQLPWRK-IKDKEQVGMIKEKYEHRM-----LLKH--MPSE 267
Query: 427 TLQKYLKVVMALTYEEKPPYAMLRNNLEALLQD 459
+L + +L Y KP Y ++ + E +++
Sbjct: 268 -FHLFLDHIASLDYFTKPDYQLIMSVFENSMKE 299
Score = 30.4 bits (67), Expect = 3.7
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 74 LSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSP 109
L L S SS SE+ +SE G+GS TP S P
Sbjct: 1103 LRLASGASSSSSEEQRRASETLSGTGSEEDTPASEP 1138
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/225 (20%), Positives = 99/225 (44%), Gaps = 26/225 (11%)
Query: 252 DKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAEN 311
D++ ++V+ GR+L + + + L++ ++L+++E +H ++H ++ N
Sbjct: 87 DRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSN 146
Query: 312 IFVD--PEDQSQVTLAGYGFAFRY---CPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG 366
+ P + + +G A ++ C + V G R G + + S++ H+
Sbjct: 147 FAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFR----GTVRYASINAHRNRE 202
Query: 367 PSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIR--- 423
R DL SL Y +++++ G LPW + + E + K+++ H +
Sbjct: 203 MGRHDDLWSLFYMLVEFVVGQLPWRK-IKDKEQVGSIKERY-----------DHRLMLKH 250
Query: 424 -PSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDP 467
P E +L + +L Y KP Y +L + + ++ V DP
Sbjct: 251 LPPE-FSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDP 294
Score = 30.4 bits (67), Expect = 3.7
Identities = 24/75 (32%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 62 KVKWSSTVTSPRLSLFSDGDSSESEDTLSSSE-RSKGSGSRPPTPKSSPQKTRKSPQVTR 120
KV SS S S + + S+ S+++ +S GS P TP SP R+SP +
Sbjct: 1096 KVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASP 1155
Query: 121 GS---PQKTSCSPQK 132
S P+ +S SP +
Sbjct: 1156 RSSSLPRTSSSSPSR 1170
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 47.8 bits (112), Expect = 2e-05
Identities = 37/120 (30%), Positives = 60/120 (50%), Gaps = 6/120 (5%)
Query: 272 VSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAF 331
++ K LSE+ + LL+A+ FLH N VH ++ ENI +D D Q+ L+ +GF+
Sbjct: 119 LTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD--DNMQIRLSDFGFSC 176
Query: 332 RYCPSGKHVAYVEGSRSPHEGDLEFISMD-LHKGCGPSRRSDLQSLGYCMLKWLYGFLPW 390
P G+ + + G+ ++ SMD H G G + DL + G + L G P+
Sbjct: 177 HLEP-GEKLRELCGTPGYLAPEILKCSMDETHPGYG--KEVDLWACGVILFTLLAGSPPF 233
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 47.0 bits (110), Expect = 4e-05
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)
Query: 273 SPKHVLS------ERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAG 326
S H+LS E V+ +LL L +LHEN+ +H +V N+ +D Q ++ +A
Sbjct: 1330 SVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQ-RLRIAD 1388
Query: 327 YGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYG 386
+G A R G +G G + F++ ++ +G R D+ S+G +++
Sbjct: 1389 FGAAARLASKGTGAGEFQGQLL---GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACA 1445
Query: 387 FLPW 390
PW
Sbjct: 1446 KPPW 1449
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 46.6 bits (109), Expect = 5e-05
Identities = 41/140 (29%), Positives = 60/140 (42%), Gaps = 10/140 (7%)
Query: 41 HVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGS 100
H + ++RG SS E K + T PR S S E S RS+ + S
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTK------SRTPPRRR--SSRSSPELTRKARLSRRSRSASS 1712
Query: 101 RPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTR--QSPQTLKRSRVTTSLEALPTGTVL 158
P T +P + R+SP V+ P + S S ++ R SP+T SR S P G
Sbjct: 1713 SPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQR 1772
Query: 159 TDKSGRQWKLKSFQTRDNQG 178
+ R+ K ++ + RD G
Sbjct: 1773 SRSRSRREKTRTTRRRDRSG 1792
Score = 46.6 bits (109), Expect = 5e-05
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 23 GNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDS 82
G+SLPV+ V + +P + + + G E +P K K S+ +S S S S
Sbjct: 2565 GSSLPVQPEVALKRVPSPTPAPKEAVREGRPP--EPTPAKRKRRSSSSSSSSSSSSSSSS 2622
Query: 83 SESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQV--TRGSPQKTSCSPQKTRQSPQTL 140
S S + SSS S S S + SSP + PQ SP+K +++R + +
Sbjct: 2623 SSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPI 2682
Query: 141 KRSRVTTSLEALP 153
R + SL P
Sbjct: 2683 DSLRDSRSLSYSP 2695
Score = 32.0 bits (71), Expect = 1.3
Identities = 27/82 (32%), Positives = 35/82 (42%), Gaps = 10/82 (12%)
Query: 70 TSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKS------SPQKTRKSPQVTRGSP 123
T PR S G S + + RS+ S S PP KS S + P+V G+P
Sbjct: 792 TPPRRS--RSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTP 849
Query: 124 --QKTSCSPQKTRQSPQTLKRS 143
Q + SPQ QS +RS
Sbjct: 850 PRQGSITSPQANEQSVTPQRRS 871
Score = 31.2 bits (69), Expect = 2.1
Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 16/100 (16%)
Query: 60 PKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGS-----------RPPTPKSS 108
P K + SS+ +S S S SS S + S S S GS R P+P +
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 109 PQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTS 148
P++ V G P + + + +K R S + S ++S
Sbjct: 2586 PKEA-----VREGRPPEPTPAKRKRRSSSSSSSSSSSSSS 2620
Score = 30.8 bits (68), Expect = 2.8
Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 13/108 (12%)
Query: 58 TSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLS----SSERSKGSGSRPPTPK------- 106
TS ++ T T S + D D + E + + S ERS +G PP P
Sbjct: 316 TSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSS-TGPEPPAPTPLLAERH 374
Query: 107 -SSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALP 153
SPQ +P + SP + R P++ ++ ++S E+ P
Sbjct: 375 GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSP 422
Score = 30.4 bits (67), Expect = 3.7
Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 1/105 (0%)
Query: 43 SSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRP 102
SSF +R + + +P+ K S V S + + RS+ S R
Sbjct: 149 SSFDPQRRAREAK-QPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRR 207
Query: 103 PTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTT 147
KSS +K +S ++ ++ K + + KRSR TT
Sbjct: 208 ERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTT 252
Score = 30.4 bits (67), Expect = 3.7
Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 10/106 (9%)
Query: 44 SFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPP 103
S + S R T P K S + TSP + S S + ++ RS+ SR P
Sbjct: 1830 SSRTSSRRRRGRSRTPPTSRKRSRSRTSP-----APWKRSRSRASPATHRRSR---SRTP 1881
Query: 104 TPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQ--SPQTLKRSRVTT 147
++R SP R S +TS + +++R SP + +RSR T
Sbjct: 1882 LISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRT 1927
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 46.2 bits (108), Expect = 6e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
S DV + + E + V L ALEFLH N+ +H ++ ++N+ + E V L +
Sbjct: 330 SLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGME--GSVKLTDF 387
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 385
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 388 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMVE 438
Query: 386 GFLPWTN 392
G P+ N
Sbjct: 439 GEPPYLN 445
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 45.8 bits (107), Expect = 8e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
S DV + + E + V L ALEFLH N+ +H ++ ++NI + + V L +
Sbjct: 351 SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMD--GSVKLTDF 408
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 385
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 409 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMIE 459
Query: 386 GFLPWTN 392
G P+ N
Sbjct: 460 GEPPYLN 466
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 45.8 bits (107), Expect = 8e-05
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 13/127 (10%)
Query: 268 SALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGY 327
S DV + + E + V L ALEFLH N+ +H ++ ++NI + + V L +
Sbjct: 351 SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMD--GSVKLTDF 408
Query: 328 GFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDL--HKGCGPSRRSDLQSLGYCMLKWLY 385
GF + P + RS G +++ ++ K GP + D+ SLG ++ +
Sbjct: 409 GFCAQITPE-------QSKRSTMVGTPYWMAPEVVTRKAYGP--KVDIWSLGIMAIEMIE 459
Query: 386 GFLPWTN 392
G P+ N
Sbjct: 460 GEPPYLN 466
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,273,715
Number of Sequences: 37866
Number of extensions: 990661
Number of successful extensions: 6784
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 390
Number of HSP's that attempted gapping in prelim test: 5608
Number of HSP's gapped (non-prelim): 1393
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.