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Search of human proteins with 70980531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70980531 GGA binding partner [Homo sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70980531 GGA binding partner [Homo sapiens] 842 0.0
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 77 3e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 76 5e-14
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 76 7e-14
gi|71061468 centromere protein E [Homo sapiens] 75 1e-13
gi|148746195 trichohyalin [Homo sapiens] 75 2e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 73 6e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 73 6e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 72 1e-12
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 71 2e-12
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 70 4e-12
gi|55770834 centromere protein F [Homo sapiens] 70 5e-12
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 69 6e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 8e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 67 2e-11
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 67 3e-11
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 67 3e-11
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 67 3e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 67 3e-11
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 66 6e-11
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 66 6e-11
gi|225579095 S-phase cyclin A-associated protein in the ER isofo... 66 7e-11
gi|225579092 S-phase cyclin A-associated protein in the ER isofo... 66 7e-11
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s... 66 7e-11
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa... 66 7e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 66 7e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 66 7e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 66 7e-11
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 66 7e-11
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 66 7e-11
>gi|70980531 GGA binding partner [Homo sapiens]
Length = 441
Score = 842 bits (2175), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIG 60
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIG
Sbjct: 1 MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIG 60
Query: 61 CLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD 120
CLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD
Sbjct: 61 CLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD 120
Query: 121 DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE 180
DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
Sbjct: 121 DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE 180
Query: 181 AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAI 240
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAI
Sbjct: 181 AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAI 240
Query: 241 EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNK 300
EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNK
Sbjct: 241 EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNK 300
Query: 301 EALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQ 360
EALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQ
Sbjct: 301 EALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQ 360
Query: 361 EQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
EQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL
Sbjct: 361 EQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
Query: 421 FLSCAQKQLSALIATEPVDIE 441
FLSCAQKQLSALIATEPVDIE
Sbjct: 421 FLSCAQKQLSALIATEPVDIE 441
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 77.0 bits (188), Expect = 3e-14
Identities = 82/320 (25%), Positives = 152/320 (47%), Gaps = 56/320 (17%)
Query: 145 LKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRK 204
LK S +E QRI +++ E+ LE ++ +++E + R ELQ+ K E E +R+
Sbjct: 558 LKNSRKEHQRILARRQTIEERKERLESLNIQREKEE---LEQREAELQKVRKAEEERLRQ 614
Query: 205 AGHEA-LSIIVDEYKALLQSSVKQQVEAIEKQYISA------------------------ 239
E I+ E++ + + +V++++E I+K + A
Sbjct: 615 EAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQV 674
Query: 240 --IEKQAHKCEELLNAQHQRL--------LEMLDTEKELLKE-KIKEALIQQSQEQKEIL 288
+EK+ + +E L Q +++ LE + K +E +IK+ + + QE++ I
Sbjct: 675 EQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERIT 734
Query: 289 EKCLEEERQRNKEALVSAAKLEKEA----VKDAVLKVVEEERKNLEKAHAEERELWKTEH 344
LE E+ + +S +++ +K A V EE+ K E+ AEER + E
Sbjct: 735 TMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHN-RLEE 793
Query: 345 AKDQEKVSQEI----QKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
K Q K + I +K +EQR+ ++ +K EE++R+E+A E +EL EY
Sbjct: 794 RKRQRKEERRITYYREKEEEEQRRAEEQMLKER--EERERAERAKRE------EELREYQ 845
Query: 401 KEQKRLDQVIRQRSLSSLEL 420
+ K+L++V R++ LE+
Sbjct: 846 ERVKKLEEVERKKRQRELEI 865
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/312 (20%), Positives = 137/312 (43%), Gaps = 52/312 (16%)
Query: 121 DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE 180
+ E+ + +Q +K ++ + E EK+RI Q+ E + +K +K+ E
Sbjct: 590 EKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELG 649
Query: 181 AISFQD----------------RYKELQEKHKQELEDMRKAGHEALSII-----VDEYKA 219
A +F+D + E EK K+EL++ K + + ++E
Sbjct: 650 AKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPL 709
Query: 220 LLQSSVKQQV------EAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLD--------TE 265
+ + +Q++ E E++ I+ ++ + K E N R+LE D
Sbjct: 710 IKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRM-SRMLEDRDLFVMRLKAAR 768
Query: 266 KELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEE 325
+ + +EK+K+ + ++E+ LE E +RQR +E ++ + ++E EE+
Sbjct: 769 QSVYEEKLKQFEERLAEERHNRLE---ERKRQRKEERRITYYREKEE----------EEQ 815
Query: 326 RKNLEKAHAEERELWKTEHAKDQEKV---SQEIQKAIQEQRKISQETVKAAIIEEQKRSE 382
R+ E+ E E + E AK +E++ + ++K + +RK Q ++ E ++ E
Sbjct: 816 RRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEE 875
Query: 383 KAVEEAVKRTRD 394
+ + ++ +D
Sbjct: 876 RRLGDSSLSRKD 887
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/185 (23%), Positives = 90/185 (48%), Gaps = 29/185 (15%)
Query: 271 EKIKEA-LIQQSQEQKEI-LEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKN 328
E IK A ++Q+ +EQ ++ + L+ R+ ++ L +E+ + L + + E++
Sbjct: 535 EVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNI-QREKEE 593
Query: 329 LEKAHAEERELWKTEHAK-DQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE- 386
LE+ AE +++ K E + QE +E ++ +QE +I ++TV+ +E+ K++E +
Sbjct: 594 LEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRER-LEQIKKTELGAKA 652
Query: 387 ----------------------EAVKRTRDELIEYIKEQ-KRLDQVIRQRSLSSLELFLS 423
E +++ + EL E +K Q K++D R + L + L S
Sbjct: 653 FKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKS 712
Query: 424 CAQKQ 428
++Q
Sbjct: 713 AYEEQ 717
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 76.3 bits (186), Expect = 5e-14
Identities = 77/329 (23%), Positives = 157/329 (47%), Gaps = 35/329 (10%)
Query: 133 QLQQKISSLE-----IKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR 187
QLQQK+ LE + +V+E E Q K+DV + ++ H + + +++ E++ + +
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQ--KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
Query: 188 YKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVE-AIEKQYISAIEKQAHK 246
K L + ++ +LED K + I+V++ +LQ Q+ E I Q +SA E H
Sbjct: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940
Query: 247 CEELLNAQ---HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKE-- 301
E + ++ +E + + + ++E +K+ L+ Q + K+ LE E Q+ K+
Sbjct: 941 LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 302 -ALVSAAKLEKEAVKDAVLKVVEEERKNLEK-AHAEEREL------WKTEHAKDQEKVSQ 353
++ A+ + DAV ++ +++ +E REL W+ + + E++ +
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 354 ----EIQKAIQEQRKISQETVKAAIIEEQKRSEKA--VEEAVKR--TRDELIEYIKEQK- 404
++Q+ QE ++ Q+ + +E+ E EE VK+ T +EL E +K++
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120
Query: 405 -----RLDQVIRQRSLSSLELFLSCAQKQ 428
D+ + L LE+ L+ + K+
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKE 1149
Score = 68.9 bits (167), Expect = 8e-12
Identities = 66/266 (24%), Positives = 139/266 (52%), Gaps = 23/266 (8%)
Query: 145 LKVSEEEKQRIKQDVESL-MEKHNVL--EKGFLKEKEQEAISFQDRYKELQEKHKQELED 201
LK+S+E++Q+ +E L ++K +L + L++ +QEA +++ R EL+ ++ L++
Sbjct: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
Query: 202 MRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEM 261
+ + L++ ++ K + +++ + +++ + +E H+ + L + Q L +
Sbjct: 583 NKNQSKD-LAVHLEAEK----NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
Query: 262 LDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKV 321
TE E L+EK ++ ++++ I + +EE ++ LEK VK L+
Sbjct: 638 YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKT---------LEKLDVKQTELES 688
Query: 322 VEEERKNLEKA-HAEERELWKTEHAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQK 379
+ E + KA H E EL KDQ +K+ QE++ + EQ+ Q+ V +II+E +
Sbjct: 689 LSSELSEVLKARHKLEEEL---SVLKDQTDKMKQELEAKMDEQKNHHQQQVD-SIIKEHE 744
Query: 380 RSEKAVEEAVKRTRDELIEYIKEQKR 405
S + E+A+K ++L +KE+ +
Sbjct: 745 VSIQRTEKALKDQINQLELLLKERDK 770
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/284 (22%), Positives = 137/284 (48%), Gaps = 25/284 (8%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQ---E 198
E K K E++ +++KQ + + E L+K L ++ + ++ EL +K KQ +
Sbjct: 946 ETKFKNQEKKMEKVKQKAKEMQE---TLKKKLLDQEAKLKKELENTALELSQKEKQFNAK 1002
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRL 258
+ +M +A +S V L+++ K+Q+E++ + + + E+ LN Q + L
Sbjct: 1003 MLEMAQANSAGISDAVSR----LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
Query: 259 LEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVK-DA 317
E+ + + + ++++ E +QK +L C +EE NKE L++E VK D
Sbjct: 1059 QEIHEIQLQEKEQEVAEL------KQKILLFGCEKEEM--NKEI----TWLKEEGVKQDT 1106
Query: 318 VLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAII-E 376
L ++E+ K + AH +T+ EK+ ++ K+++E + ++ V+ ++ E
Sbjct: 1107 TLNELQEQLKQ-KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
Query: 377 EQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
E KR + +K T +E ++ ++ + +SL +L
Sbjct: 1166 EDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Score = 62.0 bits (149), Expect = 1e-09
Identities = 71/283 (25%), Positives = 132/283 (46%), Gaps = 32/283 (11%)
Query: 138 ISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL--EKGFLKEKEQEAISFQDRYKELQEKH 195
+ +L+ ++K E +R K+ ++S E+ +L EK L+E+ E + ++ K+L
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 196 KQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEK------QYISAIEKQAHKCEE 249
K +L + + + + ++ + +Q E +E Q S I++ + EE
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 250 LLN-------AQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEA 302
L A + L + L T ++ E+ + L + EQ + +EK EEER ++
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKT--EEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAH-----AEERELWK---TEHAKDQEKVSQE 354
L K+ V D + K EE+ L+K H +E+EL K T + QE++
Sbjct: 459 LSRV----KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 355 IQKAIQEQRKISQ--ETVKAAIIEEQKRSEKAV-EEAVKRTRD 394
++K+ E KISQ E ++ +EE + +KA+ E+ + RD
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD 557
Score = 57.4 bits (137), Expect = 3e-08
Identities = 76/335 (22%), Positives = 156/335 (46%), Gaps = 51/335 (15%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDV---ESLMEKHNVLEKGFLKEKEQ 179
+D G ++ + Q +LE+K + + + RIKQ E L E+ E+ +E E+
Sbjct: 360 QDKGMVIAETKRQMH-ETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418
Query: 180 EAISFQDRYKELQEKHKQEL-----------EDMRKAGHEALSIIVDEYKALLQSSVKQQ 228
A+S + +E + K K E+ E+ R + + LS + E +++ S ++Q
Sbjct: 419 -ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477
Query: 229 VEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL 288
+ ++K + EK+ + E Q L + L T + +E++K AL + Q E L
Sbjct: 478 IAKLQKLH----EKELARKE-------QELTKKLQTREREFQEQMKVAL---EKSQSEYL 523
Query: 289 EKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQ 348
+ E+E+Q S A E E K A+L E + ++L+ +E E ++T
Sbjct: 524 KISQEKEQQE------SLALEELELQKKAILTESENKLRDLQ----QEAETYRTRIL--- 570
Query: 349 EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQK---- 404
++ ++K++QE + S++ + + E+ + K + V++ + EL E +K Q+
Sbjct: 571 -ELESSLEKSLQENKNQSKD-LAVHLEAEKNKHNKEITVMVEKHKTEL-ESLKHQQDALW 627
Query: 405 -RLDQVIRQRSLSSLELFLSCAQKQLSALIATEPV 438
QV++Q+ + +E +++ L+ + +
Sbjct: 628 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662
Score = 57.4 bits (137), Expect = 3e-08
Identities = 73/284 (25%), Positives = 124/284 (43%), Gaps = 65/284 (22%)
Query: 145 LKVSEEEKQR---IKQDVESLME-KHNVLE---KGFLKEKEQ---EAISFQDRYKELQEK 194
L+ + EEK + ++ + S ME +HN LE G +EK++ E + Q + L+++
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE 1959
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
H+QELE ++K EY + +KQ+ E +E ++ S +++ + L AQ
Sbjct: 1960 HQQELEILKK-----------EYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQL-AQ 2007
Query: 255 HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAV 314
++ LEM IKE + + + + E+LE EE Q L+K A
Sbjct: 2008 KEQELEM----------TIKETINKAQEVEAELLESHQEETNQ----------LLKKIAE 2047
Query: 315 KDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQE------ 368
KD LK + + + A EE T +D + +E+QK + Q+K+ QE
Sbjct: 2048 KDDDLKRTAKRYEEILDAREEE----MTAKVRDLQTQLEELQK--KYQQKLEQEENPGND 2101
Query: 369 -----------TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIK 401
K +I + K E+ E + D L +Y K
Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 55.8 bits (133), Expect = 7e-08
Identities = 69/356 (19%), Positives = 169/356 (47%), Gaps = 57/356 (16%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL----EKGFLKEKEQEAISFQDR--- 187
++KIS L+ L E+ QR+ Q+ E + H + ++ +K + EA +D+
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 188 ---YKELQEKHKQ----ELEDMRKAG-------HEALSIIVDEYKALLQSS------VKQ 227
+EL+EK+K+ + + K G + L + D+ + LQ ++Q
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854
Query: 228 QVEAIEKQYISAIEKQAHKCE-ELLNAQHQRL--LEMLDTEK---ELLKEKIKEALIQQS 281
+++ ++ + +K+ H+ E E L +++++L L+ +D ELL+E +E
Sbjct: 1855 KIKELDSCLVR--QKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 282 QEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWK 341
+ K + E + + E ++ A+ EK+ + +++ ++++ + L K H +E E+ K
Sbjct: 1913 VQPKLLSNM---EAQHNDLEFKLAGAEREKQKLGKEIVR-LQKDLRMLRKEHQQELEILK 1968
Query: 342 TEHAKD-QEKVSQEIQKAIQEQRKISQETVK---AAIIEEQKRSEKAVEEAVKRTRD--- 394
E+ ++ +EK+ QE + + ++ ++ + ++++ E ++E + + ++
Sbjct: 1969 KEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEA 2028
Query: 395 ELIEYIKEQKRLDQVIR---------QRSLSSLELFLSCAQKQLSALIATEPVDIE 441
EL+E Q+ +Q+++ +R+ E L +++++A + +E
Sbjct: 2029 ELLE--SHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/344 (21%), Positives = 151/344 (43%), Gaps = 44/344 (12%)
Query: 119 VDDSEDPGANVSNIQLQQK---ISSLEIKLKV----SEEEKQRIKQDVES----LMEKHN 167
++ S+ +S + QQ+ + LE++ K SE + + ++Q+ E+ ++E +
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 168 VLEKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGH----EALSII 213
LEK + K Q E + EKHK ELE ++ E L ++
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634
Query: 214 VDEYKA---LLQSSVKQQVEAIEKQ----YISAIEKQAHKCEELLNAQHQRLLEMLDTEK 266
+Y+ L+ +Q+ E + K + + IE+ K E L+ + L +
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELS 694
Query: 267 ELLKEKIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKV 321
E+LK + K L Q+ + K+ LE ++E++ +++ + S K E E K
Sbjct: 695 EVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK-EHEVSIQRTEKA 753
Query: 322 VEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQ-----ETVKAAIIE 376
++++ LE +ER+ EH E + +I+++ E ++ S ++ ++A E
Sbjct: 754 LKDQINQLELL-LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 377 EQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
+ K E+ + + ++ D E I K++ +V Q+ EL
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Score = 52.0 bits (123), Expect = 1e-06
Identities = 64/329 (19%), Positives = 149/329 (45%), Gaps = 32/329 (9%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E + +++ E+ A ++ + E+K K ++ KQ + + EK
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 170 EKGF----------LKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+KG L+E+E+E +++ K ++ + L R A + ++ ++ +A
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSA--KNVAAYTEQEEA 1724
Query: 220 LLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE------KI 273
Q V++ E + IS +++ + E+LL Q E + + E+ + K+
Sbjct: 1725 DSQGCVQKTYE----EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 274 KEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAH 333
+ A +Q ++Q I E E + K +L+ A +EKE K+ + + ++NLE
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI-----QAKQNLENVF 1835
Query: 334 AEERELWKTEHAKDQ--EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKR 391
+ ++ + + Q E+ +E+ + Q+++ + ++ + +K +A+++ R
Sbjct: 1836 DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL--QALQQMDGR 1893
Query: 392 TR-DELIEYIKEQKRLDQVIRQRSLSSLE 419
+ EL+E E+K +++ + LS++E
Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNME 1922
Score = 48.9 bits (115), Expect = 9e-06
Identities = 41/192 (21%), Positives = 93/192 (48%), Gaps = 16/192 (8%)
Query: 143 IKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDM 202
+K + +E +++IKQ+ E L KHN K ++E + + +EL+ K+ +
Sbjct: 1967 LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ---LAQKEQELEMTIKETINKA 2023
Query: 203 RKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRL---L 259
++ E L +E LL+ ++ + +++ A + EE+L+A+ + + +
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDD---------LKRTAKRYEEILDAREEEMTAKV 2074
Query: 260 EMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVL 319
L T+ E L++K ++ L Q+ + + + + K L+S +KL+++ ++ +
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134
Query: 320 KVVEEERKNLEK 331
+E+ K EK
Sbjct: 2135 N-LEDRLKKYEK 2145
Score = 45.1 bits (105), Expect = 1e-04
Identities = 61/306 (19%), Positives = 129/306 (42%), Gaps = 29/306 (9%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGF--LK-EKEQEAISFQDRYK 189
Q Q + L+I+L++ +E + + L E+ + K F LK E E + + +
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 190 ELQEKHKQ------ELED---MRKAGHEALSIIVDEYKALLQSSVKQQVEAIE------K 234
L+ + K ELED + E+L+ ++ Y K+ V+ ++ +
Sbjct: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 235 QYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEE 294
+ + +++ K L N + E+ +KEL + ++ +E+ + LE LE
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS---VKSKEEELKALEDRLES 1631
Query: 295 ERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEK---AHAEERELWKTEHAKDQEKV 351
E L A+ + A+K +L +EE+ + +K +H E E ++ +
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 352 SQEIQKAIQEQRKI-----SQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRL 406
++++ Q + S + V A +E+ S+ V++ + L + E+++L
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 407 DQVIRQ 412
Q + Q
Sbjct: 1752 LQRVGQ 1757
Score = 41.6 bits (96), Expect = 0.001
Identities = 77/333 (23%), Positives = 135/333 (40%), Gaps = 69/333 (20%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQ---DRYKEL 191
++K+S L KLK ++EE Q +K E + F K E+ AI + + L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYK---------ALLQSSVKQQVEAIEKQYIS---- 238
E EL ++ + A+ + + L+++ ++EA +Q
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 239 ---AIEKQAHKCEELLN--AQHQRLLEMLDTEKELLKEK---------IKEALIQQSQEQ 284
+ ++ H+ EE N + +E L TEKE L+++ KE+ I +Q +
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI--TQLK 1345
Query: 285 KEILEK-----CLEEERQRNKEALVSAAK---------------LEKEAVKDAVLKVVEE 324
KE+ E ++EE + K + S +K EKEA ++ K +E
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405
Query: 325 ERKNL---------EKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAII 375
E+ L + + ++ E D E +K Q + Q TVK I
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 376 EEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+ + +S++A E +DE I +KE+ LDQ
Sbjct: 1466 QLELKSKEAYE------KDEQINLLKEE--LDQ 1490
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 75.9 bits (185), Expect = 7e-14
Identities = 69/307 (22%), Positives = 153/307 (49%), Gaps = 25/307 (8%)
Query: 136 QKISSLEIKLKVSEE-EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q++S L +++ S + ++ +I+ + E+ ++K L + +++ E S + + +++ E+
Sbjct: 668 QRLSWLRAQVQSSTQADEDQIRAEQEASLQK---LREELESQQKAERASLEQKNRQMLEQ 724
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K+E+E K+ AL+ + KAL Q +++Q+E K+ ++ +EK+ +A+
Sbjct: 725 LKEEIEASEKSEQAALNAAKE--KALQQ--LREQLEGERKEAVATLEKEH-------SAE 773
Query: 255 HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAV 314
+RL L+ + + +++ + + Q+++ L+KCL + R + A E E
Sbjct: 774 LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHE-- 831
Query: 315 KDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAI 374
+ ++ E+R+ +E H + K EH + K ++ + E+RK E + +
Sbjct: 832 ---LSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYE---AEERKQRAELL-GHL 884
Query: 375 IEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIA 434
E +R ++A E ++ R E + +++ +R + ++R L LEL L K + A +A
Sbjct: 885 TGELERLQRAHERELETVRQEQHKRLEDLRRRHRE-QERKLQDLELDLETRAKDVKARLA 943
Query: 435 TEPVDIE 441
V E
Sbjct: 944 LLEVQEE 950
Score = 60.8 bits (146), Expect = 2e-09
Identities = 73/289 (25%), Positives = 138/289 (47%), Gaps = 33/289 (11%)
Query: 142 EIKLKVSEEE-KQRIKQD----VESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHK 196
E LK EE Q ++QD +ES EK L + +E+E+E + L ++ +
Sbjct: 589 EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEIL-------RLHQQKE 641
Query: 197 QELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQ 256
Q L +R E L ++E +A ++ Q++ + Q S+ + + A Q
Sbjct: 642 QSLSSLR----ERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ 697
Query: 257 RLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKD 316
+L E L+++++ + ++ Q+ +++LE+ L+EE + ++++ +A KE
Sbjct: 698 KLREELESQQKAERASLE-------QKNRQMLEQ-LKEEIEASEKSEQAALNAAKEKALQ 749
Query: 317 AVLKVVEEERKN----LEKAHAEERE-LWKTEHAKDQEKVSQEIQKAIQE-QRKISQETV 370
+ + +E ERK LEK H+ E E L + AK +E VS +QK IQE Q+K +
Sbjct: 750 QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVS-SLQKKIQEAQQKEEAQLQ 808
Query: 371 KAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
K E + +K+ V EL ++E+++ + +R L ++
Sbjct: 809 KCLGQVEHRVHQKSYH--VAGYEHELSSLLREKRQEVEGEHERRLDKMK 855
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/310 (21%), Positives = 136/310 (43%), Gaps = 27/310 (8%)
Query: 144 KLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELE-DM 202
+L+ +++E + Q + L E + L+ LK + Q + Q + ++LQ KH LE +
Sbjct: 979 QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDL-LQAQSQQLQ-KHFSSLEAEA 1036
Query: 203 RKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQY-------ISAIEKQAHKCEELLNAQH 255
+K H + V+E A +E + K +S+ Q+ + L +
Sbjct: 1037 QKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSS 1096
Query: 256 QRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVK 315
+ +L E L+ KE L+QQ++ + + L+ +Q + L SA ++ K+
Sbjct: 1097 HNVWHLLSAEGVALRSA-KEFLVQQTRSMRR-RQTALKAAQQHWRHELASAQEVAKDPPG 1154
Query: 316 DAVLKVVEEERKNLEK--AHAEE-RELWKTEH---AKDQEKVSQ---EIQKAIQEQRKIS 366
+K +E+ RKNLEK H +E + + H K +EK++Q + + ++ +
Sbjct: 1155 ---IKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLG 1211
Query: 367 QETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV--IRQRSLSSLELFLSC 424
K A+ + + E+ + E+ ++Q R+D + R + L L
Sbjct: 1212 GSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQ-RIDSTPSLTSRKIHGLSHSLRQ 1270
Query: 425 AQKQLSALIA 434
QLS++++
Sbjct: 1271 ISSQLSSVLS 1280
Score = 41.2 bits (95), Expect = 0.002
Identities = 59/263 (22%), Positives = 112/263 (42%), Gaps = 28/263 (10%)
Query: 148 SEEEKQR------IKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELED 201
+EE KQR + ++E L H E+E E + Q+++K L++ ++ E
Sbjct: 871 AEERKQRAELLGHLTGELERLQRAH---------ERELETVR-QEQHKRLEDLRRRHREQ 920
Query: 202 MRKAGHEALSIIV---DEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRL 258
RK L + D L V+++ EKQ + +++Q E A HQ+L
Sbjct: 921 ERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQL 980
Query: 259 LEMLDTEKELLK--EKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKD 316
E LL+ ++++E ++ + Q +K LE ++ + ++++ + LE EA K
Sbjct: 981 EEAQKEHTHLLQSNQQLRE-ILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKK 1039
Query: 317 AVLKVVEEERKNLEKAHAEE----RELWKTEHAKDQEKVSQEIQKAIQE--QRKISQETV 370
L +N H E +L K+ ++VS + ++ ++ +S V
Sbjct: 1040 QHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNV 1099
Query: 371 KAAIIEEQKRSEKAVEEAVKRTR 393
+ E A E V++TR
Sbjct: 1100 WHLLSAEGVALRSAKEFLVQQTR 1122
Score = 35.0 bits (79), Expect = 0.14
Identities = 31/139 (22%), Positives = 71/139 (51%), Gaps = 21/139 (15%)
Query: 298 RNKEALVSAAKLEKEAVK---DAVLKVVEEERKNLEKA-------------HAEERELWK 341
R+ E + +L + A+K +AV +V+E+++++L ++ EE E+ +
Sbjct: 576 RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
Query: 342 TEHAKDQEKVS--QEIQKAIQEQ--RKISQETVKAAIIEEQ-KRSEKAVEEAVKRTRDEL 396
K+Q S + +QKAI+E+ R +E+ + + + Q + S +A E+ ++ ++
Sbjct: 636 LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
Query: 397 IEYIKEQKRLDQVIRQRSL 415
++ ++E+ Q + SL
Sbjct: 696 LQKLREELESQQKAERASL 714
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 75.1 bits (183), Expect = 1e-13
Identities = 71/298 (23%), Positives = 147/298 (49%), Gaps = 34/298 (11%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRY 188
+ ++L +K + ++K +E+ +K E+L KH+ L KE +E ++ +
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL-----KEHIRETLA---KI 1379
Query: 189 KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCE 248
+E Q K +Q L +M++ +E I+ + + + S ++E IE +S +++H
Sbjct: 1380 QESQSKQEQSL-NMKEKDNETTKIVSEMEQFKPKDSALLRIE-IEMLGLSKRLQESHDEM 1437
Query: 249 ELLNAQH---QRLLEMLDTEKELLKEKIKEALIQ--QSQEQKEILEKCLEEERQ------ 297
+ + + QRL E+L +E + LKE IKE + + +++E+ ++ CL+E+ +
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
Query: 298 ---RNKEALVSAAKLEKEAVKDAVLKVVEE--------ERKNLEKAHAEERELWK-TEHA 345
KE +S + + EA+ D + ++E K + + + EL + EH
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
Query: 346 KDQEKVSQEIQ-KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKE 402
K ++ Q I+ K ++ ++ + + I+ ++K K V+EA++ RD+L E KE
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Score = 65.5 bits (158), Expect = 9e-11
Identities = 77/359 (21%), Positives = 163/359 (45%), Gaps = 48/359 (13%)
Query: 110 EKSNGTIALVDDSED-PGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV 168
EK N T +V + E + + ++++ ++ L +L+ S +E + + ++ + L V
Sbjct: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
Query: 169 LEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSI---IVDEYKALLQSSV 225
L+ E+ ++ KE+ KH + E++ K H L ++E + L S
Sbjct: 1454 LQS--------ESDQLKENIKEIVAKHLETEEEL-KVAHCCLKEQEETINELRVNL-SEK 1503
Query: 226 KQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE--------KIKEAL 277
+ ++ I+KQ + +K +K +E+ + Q ++ + +E + E K K++
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1563
Query: 278 IQ--------------QSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVE 323
+Q +SQE+ +I+ K +EE +R +EAL KE K+ V K+ E
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIK-EKEEMKRVQEALQIERDQLKENTKEIVAKMKE 1622
Query: 324 EERK-----NLEKAHAEERELWKTEHAKDQ-EKVSQEIQKAIQEQRKISQ----ETVKAA 373
+ K + + + ++ + EH K+Q E ++ E +++Q +
Sbjct: 1623 SQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMR 1682
Query: 374 IIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSAL 432
+ +++ ++VEE +K RD+L E ++E D + +Q L + + L Q+ + L
Sbjct: 1683 SVTKERDDLRSVEETLKVERDQLKENLRETITRD-LEKQEELKIVHMHLKEHQETIDKL 1740
Score = 59.3 bits (142), Expect = 7e-09
Identities = 68/295 (23%), Positives = 139/295 (47%), Gaps = 26/295 (8%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISF-------Q 185
+LQ+K ++ +L E+ K++++ +L EK + EK Q+ + +
Sbjct: 874 ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER--EKTLITEKLQQTLEEVKTLTQEK 931
Query: 186 DRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQS--SVKQQVEAIE--KQYISA-I 240
D K+LQE + E + ++ H+ +++ +D + L + S+KQ E I K IS +
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
Query: 241 EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEK-----CLEEE 295
+ H E + + +M+ +K+ E + + EI+E+ L +E
Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE 1051
Query: 296 RQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEI 355
+ ++ L S EKE +K + + +E +N EE L E K QE V+QE
Sbjct: 1052 KNELQQMLESVIA-EKEQLKTDLKENIEMTIEN-----QEELRLLGDELKKQQEIVAQEK 1105
Query: 356 QKAIQEQRKISQETVKAAIIEEQ-KRSEKAVEEAVKRTRDELIEYIKEQKRLDQV 409
AI+++ ++S+ + A +EE+ K + ++E ++ + E + QK+++++
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Score = 53.5 bits (127), Expect = 4e-07
Identities = 60/286 (20%), Positives = 132/286 (46%), Gaps = 33/286 (11%)
Query: 106 GLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEK 165
G+ EK+N + D E SN L+ + ++ +L+++ + ++ ++ L
Sbjct: 1742 GIVSEKTNEISNMQKDLEH-----SNDALKAQDLKIQEELRIAHMHLKEQQETIDKL--- 1793
Query: 166 HNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSV 225
+G + EK + + Q + K ++++++++ H+ +++ D + + S
Sbjct: 1794 -----RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE 1848
Query: 226 KQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQE-Q 284
+Q++ K + K + L H+ L EM K ++KE+ ++++ + +
Sbjct: 1849 MEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM----KSVMKERDNLRRVEETLKLE 1904
Query: 285 KEILEKCLEEERQRNKEA---LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWK 341
++ L++ L+E + R+ E L +A L KE K+ V K+ E+ E+ +
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKEH-KETVDKLREK---------ISEKTIQI 1954
Query: 342 TEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEE 387
++ KD +K E+QK IQE +K +E + E+ S K + E
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQK--KELQLLRVKEDVNMSHKKINE 1998
Score = 52.8 bits (125), Expect = 6e-07
Identities = 81/362 (22%), Positives = 155/362 (42%), Gaps = 87/362 (24%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL--EKGFLKEKEQEAISFQDRYKEL 191
++ K+ L +L+ S+EE Q + ++ E + L E+ LKE +E ++ + KE
Sbjct: 1567 IESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA---KMKES 1623
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
QEK Q L+ + ++ K ++ K +E IE + I + EE+
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLTQILHENLEEMR 1682
Query: 252 NAQHQR-----LLEMLDTEKELLKEKIKEALIQ--QSQEQKEILEKCLEEERQR------ 298
+ +R + E L E++ LKE ++E + + + QE+ +I+ L+E ++
Sbjct: 1683 SVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRG 1742
Query: 299 ---NKEALVSAAKLEKEAVKDAV----LKVVEEER------------------------- 326
K +S + + E DA+ LK+ EE R
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802
Query: 327 ------KNLEKAHAEERE----LWKTEHA---------KDQEKVSQ--EIQKAIQEQ--- 362
K+LE ++A+ +E L EH + Q+KVS+ +++K I++Q
Sbjct: 1803 KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT 1862
Query: 363 ------------RKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVI 410
+K+ + + + +++ + + VEE +K RD+L E ++E K D I
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI 1922
Query: 411 RQ 412
+Q
Sbjct: 1923 QQ 1924
Score = 52.4 bits (124), Expect = 8e-07
Identities = 69/293 (23%), Positives = 139/293 (47%), Gaps = 30/293 (10%)
Query: 137 KISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHK 196
+++ +E KLK ++ Q +Q + ++ E+ + ++K K E E + + + KEL +H
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK---KINEIENLKNELKNKELTLEHM 1177
Query: 197 Q----ELEDMRKAGHEALSIIVDEYKAL--LQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+ EL +E + I E K L LQ S + + + + + YI IE + +E
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL-RGYIREIEATGLQTKEE 1236
Query: 251 LNAQHQRLLEMLDTEKELLKE-KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL 309
L H L E +T EL + K A I +Q+ ++ K EE +
Sbjct: 1237 LKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE---------IPVLHE 1287
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQ-EIQKA-IQEQRKISQ 367
E+E + + +K V E ++ + + L + KD +++ E+++ + E+ + SQ
Sbjct: 1288 EQELLPN--VKEVSETQETMNELEL----LTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 368 ETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
E +K+ + +++ + K ++EA++ D+L E+I+E Q + + SL +
Sbjct: 1342 EEIKS--LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM 1392
Score = 48.9 bits (115), Expect = 9e-06
Identities = 53/323 (16%), Positives = 154/323 (47%), Gaps = 36/323 (11%)
Query: 116 IALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEK---------QRIKQDVESLMEKH 166
+ L+ + + + V ++ + + S E+ + SE++K R++ +E + +
Sbjct: 743 VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802
Query: 167 NVLE--KGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYK-----A 219
+ L + K +QE +F+ + + ++K+K LE+ + E +++ + K
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
Query: 220 LLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQR--LLEMLDTEKELLKEKIKEAL 277
L++ + + + ++++ ++++ ++ E+L R L+ ++ EK L+ EK+++ L
Sbjct: 863 ALKTELSYKTQELQEK-TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL 921
Query: 278 -----IQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKA 332
+ Q ++ + L++ L+ ER + K + + + +E+ +N ++
Sbjct: 922 EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID---------TQEQLRNALES 972
Query: 333 HAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRT 392
+ +E T +K E+VS+ + ++E +++ + ++ K+ + + T
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLH--MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT 1030
Query: 393 RD-ELIEYIKEQKRLDQVIRQRS 414
D + E I++Q+++ +I++++
Sbjct: 1031 ADVKDNEIIEQQRKIFSLIQEKN 1053
Score = 48.9 bits (115), Expect = 9e-06
Identities = 48/245 (19%), Positives = 116/245 (47%), Gaps = 26/245 (10%)
Query: 149 EEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHE 208
E+ K I+++ + + + +N + E+ F++R + ++ +Q+L+ +++ +
Sbjct: 2283 EKLKNGIQKENDRICQVNNFFNNRIIAIMN-ESTEFEERSATISKEWEQDLKSLKEKNEK 2341
Query: 209 ALSIIVDEYKALLQS-----SVKQQVEAIEKQYIS--AIEKQAHKCEELLNAQHQRLLEM 261
+ Y+ L S V + + +++ A + K EL N+ H+
Sbjct: 2342 ----LFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA 2397
Query: 262 LDTEKELLKEK----IKEALIQQSQEQKEILEKCLEEERQ-----RNKEALVSAAKLEKE 312
+ E +++K + + +I + Q + KCLE+ ++ ++K AL AK KE
Sbjct: 2398 MHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL--GAKPYKE 2455
Query: 313 AVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKA 372
++D +K+V+ + + ++ A E+E+ T+ + +K E+ + ++E + SQ+
Sbjct: 2456 EIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQK---EVIRLLRENLRRSQQAQDT 2512
Query: 373 AIIEE 377
++I E
Sbjct: 2513 SVISE 2517
Score = 46.2 bits (108), Expect = 6e-05
Identities = 76/361 (21%), Positives = 158/361 (43%), Gaps = 66/361 (18%)
Query: 109 DEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV 168
+ + + + L+ + ED + QK+ ++++ L S E + KQ ++L + V
Sbjct: 574 ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633
Query: 169 L-----EKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQS 223
E FL+ E + +++ KEL +KQ D + Y++ L++
Sbjct: 634 ALDAKRESAFLR---SENLELKEKMKELATTYKQMEND------------IQLYQSQLEA 678
Query: 224 SVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLL--------EMLDTEKELLKE---- 271
K QV+ +EK+ SA + K L++ + + L ++ D +KEL KE
Sbjct: 679 KKKMQVD-LEKELQSAF-NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN 736
Query: 272 -----------KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLK 320
++K + + +KEI +K E +++ + + + KE+ +L+
Sbjct: 737 EALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 321 VVEEERKNLE------KAHAEERELWKTEHAKDQEK---VSQEIQKAIQEQRKISQETVK 371
+ + + +L K+ +E + +KT H ++K V +E ++ QE +S+E K
Sbjct: 797 EIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
Query: 372 -----AAIIEEQKRSEKAVEEAVKRTRDEL--IEYIKEQ-----KRLDQVIRQRSLSSLE 419
A+ E + ++E + ++ L +E +KEQ L V R+++L + +
Sbjct: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916
Query: 420 L 420
L
Sbjct: 917 L 917
Score = 43.5 bits (101), Expect = 4e-04
Identities = 70/342 (20%), Positives = 151/342 (44%), Gaps = 65/342 (19%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEK--GFLKEKEQEAISFQDRYKE 190
Q Q+ I++L K K+SEE + + + + K +K G K+++ EA + Q +
Sbjct: 975 QHQETINTL--KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032
Query: 191 LQE--------------KHKQELEDMRKA---------------------GHEALSIIVD 215
+++ + K EL+ M ++ E L ++ D
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092
Query: 216 EYKALLQSSVKQQVEAIEKQ--------YISAIEKQAHKCEELLNAQHQRLLEMLDTEKE 267
E K + +++ AI+K+ ++ +E++ + + L + Q+LL + + E
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 268 LLKEKIKEALIQQSQEQKEILEKCLEEER-------QRNKEALVSAAKLEKEAVKDAVLK 320
+ K+ + ++ + KE+ + +E ER N E + S K E++ +K+ + K
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK-ERKVLKE-LQK 1210
Query: 321 VVEEERKNLEKAHAEERELWKTEHAKDQEKVS----QEIQKAIQE-QRKISQETVKAAII 375
E ER +L + + E E + K++ K++ +E Q+ I E +R +S++T +
Sbjct: 1211 SFETERDHL-RGYIREIEATGLQ-TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268
Query: 376 EEQKRSEKAVEE--AVKRTRDELIEYIKEQKRLDQVIRQRSL 415
++ ++S ++E V EL+ +KE + + + L
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELEL 1310
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 74.7 bits (182), Expect = 2e-13
Identities = 79/293 (26%), Positives = 139/293 (47%), Gaps = 36/293 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQR-------IKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR 187
QQ + E +L+ E EK+R +++ + E+ +L + K + QE +
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 188 YKELQEKHKQEL-EDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHK 246
K+LQ+K +Q L E+ K + E + L Q + E EK+ E+Q K
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 247 CEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
+EL + Q L E + EK L+E+ ++ ++ +Q+E E+ L EER+ +
Sbjct: 1023 KDELQQEEEQLLRE--EREKRRLQERERQYREEEELQQEE--EQLLGEERETRRRQ---- 1074
Query: 307 AKLEKEAVKDAVLKVVEEE--RKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRK 364
+LE++ K+ L+ EE+ R+ EK +ERE +++E++ QE ++ ++E+R
Sbjct: 1075 -ELERQYRKEEELQQEEEQLLREEPEKRRRQERE----RQCREEEELQQEEEQLLREER- 1128
Query: 365 ISQETVKAAIIEEQKRSEKAV---------EEAVKRTRDELIEYIKEQKRLDQ 408
E + +E Q R E+ V EE KR R EL +E++ L Q
Sbjct: 1129 ---EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Score = 68.2 bits (165), Expect = 1e-11
Identities = 72/306 (23%), Positives = 144/306 (47%), Gaps = 27/306 (8%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
Q Q+++ E +L+ E ++ R ++ E ++ E+ +++E+E Q+ +E Q
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 193 EKHKQELE--------DMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQA 244
E+ +Q+ E + + + L +E + Q +Q+ E E+Q E+Q
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL--RREQQL 383
Query: 245 HKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNK---E 301
+ ++L Q R + L E++L +E ++ +Q +++ L + EEER K E
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 302 ALVSAAKLEKEAVKDAVLKVVEEERKNLEK--------AHAEERELW-KTEHAKDQEKVS 352
K E+E +D + + E ER E+ E RE W K E + +E+
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 353 QEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI---KEQKRLDQV 409
+ Q+ +EQ + ++ +K EE+ + E+ ++R ++E E + +E+KRL+Q
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 410 IRQRSL 415
R++ L
Sbjct: 562 RREQRL 567
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/272 (23%), Positives = 132/272 (48%), Gaps = 36/272 (13%)
Query: 133 QLQQKISSL---EIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYK 189
+LQQK L E + + +E +++ +++ E E+ +L + K + QE +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 190 ELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQY----ISAIEKQAH 245
ELQ++ +Q L + R+ K LQ +Q E E Q + E++
Sbjct: 1025 ELQQEEEQLLREERE-------------KRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 246 KCEELLNAQHQRLLEMLDTEKELLKE-------KIKEALIQQSQEQKEILEKCLEEERQR 298
+ +EL Q+++ E+ E++LL+E + +E ++ +E ++ E+ L EER++
Sbjct: 1072 RRQEL-ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 299 NKEALVSAAKLEKEAVKDAVLKVVEEE-----RKNLEKAHAEERELWKTEH---AKDQEK 350
+ + E+E V+ +++ EE R+ LE+ + EE EL + E ++QEK
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 351 VSQEIQKAIQEQRKISQETVKAAIIEEQKRSE 382
QE ++ +E+ ++ ++ K +E +RS+
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Score = 66.6 bits (161), Expect = 4e-11
Identities = 61/271 (22%), Positives = 128/271 (47%), Gaps = 35/271 (12%)
Query: 150 EEKQRIKQDVESLMEKHNVLEKGFLKE---KEQEAISFQDRYKELQEKHKQELEDMRKAG 206
++K R + + E +H + K L+E KEQ+ + ++ + +E+ K+ ++ +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 207 HEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEK 266
E + +E + L + K++ + E+QY +K+ + EE ++L E
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRK--DKKLQQKEE----------QLLGEEP 978
Query: 267 ELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEER 326
E + + +E ++ +E ++ E+ L EER++ + +K+ ++ +++ EER
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 327 KNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAV- 385
EK +ERE +++E++ QE ++ + E+R ET + +E Q R E+ +
Sbjct: 1039 ---EKRRLQERE----RQYREEEELQQEEEQLLGEER----ETRRRQELERQYRKEEELQ 1087
Query: 386 --------EEAVKRTRDELIEYIKEQKRLDQ 408
EE KR R E +E++ L Q
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQ 1118
Score = 65.1 bits (157), Expect = 1e-10
Identities = 60/265 (22%), Positives = 135/265 (50%), Gaps = 15/265 (5%)
Query: 142 EIKLKVSEEEKQR-IKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELE 200
E +LK +EE++ +K++ E+ + ++ +++E+E ++R+ +L+E+ ++E +
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---RERWLKLEEEERREQQ 500
Query: 201 DMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLE 260
+ R+ + E + + +K+Q E Q E+Q + +E + ++LL+
Sbjct: 501 ERREQQ------LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE---ERREQLLK 551
Query: 261 MLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLK 320
+ EK L +E+ ++ L ++ +E+++ L K EEER++ + +LE+ ++ V +
Sbjct: 552 R-EEEKRLEQERREQRLKREQEERRDQLLK-REEERRQQRLKREQEERLEQRLKREEVER 609
Query: 321 VVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKR 380
+ +EER+ E E + + K +E+ + Q+ +EQ++ ++ +K EE+
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 381 SEKAVEEAVKRTRDELIEYIKEQKR 405
E +R EL E +EQ R
Sbjct: 670 QRLKREHEEERREQELAEEEQEQAR 694
Score = 65.1 bits (157), Expect = 1e-10
Identities = 70/291 (24%), Positives = 139/291 (47%), Gaps = 23/291 (7%)
Query: 133 QLQQKISSL---EIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYK 189
QLQQ+ L E + + +E +++ ++D + ++ +L + K + QE +
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 190 ELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQV-EAIEKQYISAIEKQAHKCE 248
ELQ++ +Q L + R+ K LQ +Q + E EK+ + E+Q + E
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054
Query: 249 ELLNAQHQRLLEMLDTEK--ELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
EL + Q L E +T + EL ++ KE +QQ +EQ L EE ++ +
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ------LLREEPEKRRRQERER 1108
Query: 307 AKLEKEAVKDAVLKVVEEE-----RKNLEKAHAEERELWKTE----HAKDQEKVSQEIQK 357
E+E ++ +++ EE R+ LE+ + EE E+ + E + +++ QE+++
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168
Query: 358 AIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+E+ ++ QE + E++KR ++ E R +EL ++Q+ D+
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQE--RERQYREEEELQRQKRKQRYRDE 1217
Score = 64.3 bits (155), Expect = 2e-10
Identities = 63/285 (22%), Positives = 137/285 (48%), Gaps = 9/285 (3%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYK---ELQEKHKQE 198
E KL+ E ++QR Q+ E + K LE+ L+ + QE Q R + +L+ K ++E
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRK---LERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRL 258
+ ++ E + + Q ++Q E E+Q E++ + + + +R
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 259 LEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ-RNKEALVSAAKLEKEAVKDA 317
+ L E++L +E+ Q +EQ+ E+ L E+Q R ++ L +L +E ++
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 318 VLKVVEEERKN--LEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAII 375
+ E+ER+ L++ E R+ K E ++ + + Q+ ++Q + +E
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 376 EEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
EE++ ++ E+ ++R ++E E +++ ++ ++QR S +L
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Score = 63.5 bits (153), Expect = 4e-10
Identities = 63/276 (22%), Positives = 131/276 (47%), Gaps = 14/276 (5%)
Query: 135 QQKISSLEIKLKVS-EEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQE 193
+Q++S E K EE+K R ++ ME L + +E +Q+ +DR E
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR---QEGQQQLRQERDRKFREDE 1625
Query: 194 KHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNA 253
+ QE E+ + E ++E L + +QQ+ + E+ + EE
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 254 QHQRLLEMLDTEKELLKEKIKEALIQQSQE-QKEILEKCLEEERQRNKEALVSAAKLEKE 312
+ +R + + E++L +++ + +Q+ Q+ +++ LE+ EE Q +E + E+
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE-----TEQEQL 1740
Query: 313 AVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKA 372
++ K++EEE+ E+ + R + +++E++ QE +EQ+ SQE+ +
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE----REEQQLRSQESDRK 1796
Query: 373 AIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
EEQ R E+ ++ + RD + +EQ +L++
Sbjct: 1797 FREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Score = 63.2 bits (152), Expect = 5e-10
Identities = 58/284 (20%), Positives = 134/284 (47%), Gaps = 18/284 (6%)
Query: 150 EEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEA 209
+E++R + E EK LE+ + +++E + ++E +E+ +E + GHE
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 210 LSIIVDEY---KALLQSSVK-------QQVEAIEKQYISAIEKQAHKCEELLNAQHQRLL 259
+E + LL+ K Q+ E ++ + EK+ K E +L + ++L
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 260 EM-------LDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKE 312
E L E+E L++ ++ L ++ QE+++ ++ E++ R K+ + E+
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 313 AVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKA 372
+ + EE R+ + EER + +++E+ Q++++ +E+R+ Q +
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 373 AIIEEQK-RSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSL 415
+ EQ+ R E+ + + R++ + ++ +R Q+ R++ L
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Score = 61.2 bits (147), Expect = 2e-09
Identities = 66/311 (21%), Positives = 149/311 (47%), Gaps = 48/311 (15%)
Query: 146 KVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKA 205
++ +EE+Q ++++ E + LE+ + +E+E + Q +E +++ +QELE +
Sbjct: 1115 ELQQEEEQLLREEREK--RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 206 GHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQR--LLEMLD 263
E + E + LL+ +++ + E+QY E Q K ++ + QR L +
Sbjct: 1173 EEE----LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228
Query: 264 TEKELLKE---------------KIKEALIQQSQEQKEILEKCLEEERQRNKEA------ 302
EKE +++++ ++ Q Q++ L+ L E+++R++E
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQ 1287
Query: 303 -----LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQK 357
+LE+E K+A K ++ EE++L + E +++++ QE +
Sbjct: 1288 QRDRHFPEEEQLEREEQKEA---------KRRDRKSQEEKQLLREE--REEKRRRQETDR 1336
Query: 358 AIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSS 417
+E+ ++ QE + + Q+R K EE + R +++ ++++E++RL + R+R
Sbjct: 1337 KFREEEQLLQEREEQPL-RRQERDRKFREEEL-RHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 418 LELFLSCAQKQ 428
E L C +++
Sbjct: 1395 EEQQLRCQERE 1405
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/286 (19%), Positives = 139/286 (48%), Gaps = 10/286 (3%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----EQEAISFQDRYKE 190
QQ+ + ++ EEEK+ K++ E+ + E+ +++ E+E + +R +
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+E+ ++E + R + L +E + Q ++Q E E+Q ++ + EE
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 251 LNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI-LEKCLEEERQRNKEALVSAAKL 309
Q +R E E++L +E+ +E QQ + ++++ E+ L E+Q +E +
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE---QQLRR 403
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E++ ++ L+ ++ R+ + +E E + +H +QE+ Q +++ +E+R +
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKH--EQERREQRLKREQEERRDWLKRE 461
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSL 415
+ E+++R ++ + + R+ ++ +E++R Q R++ L
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Score = 60.8 bits (146), Expect = 2e-09
Identities = 59/272 (21%), Positives = 129/272 (47%), Gaps = 19/272 (6%)
Query: 149 EEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELE------DM 202
E+E++R +++ E ++ + +E+++ ++Q + +E E+ +Q L +
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 203 RKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEML 262
R+ A E + L + K+Q ++ EK+ EE Q + + L
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRRER----EKELQFLEEEEQLQRRERAQQL 849
Query: 263 DTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVV 322
E++ L+E +E Q Q + + LEEER+R + L + L+++ K+ +++
Sbjct: 850 QEEEDGLQED-QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ--QLL 906
Query: 323 EEERKNLEKAHAEERELWKTEHA-KDQEKVSQEIQKAIQEQRKISQETVKAAIIE----- 376
+EE + L++ E+R + E +++E++ QE ++ ++E+R+ + +
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 377 EQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+QK + EE KR R E + +E++ L Q
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Score = 59.7 bits (143), Expect = 5e-09
Identities = 58/313 (18%), Positives = 144/313 (46%), Gaps = 34/313 (10%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVES----LMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
+Q + E K E +QR+K++ E L+++ + LK +++E + + + +E
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 191 LQEKHKQELEDMRKAGHEALS------IIVDEYKALLQSSVKQQVEAIEKQYISAIEKQA 244
++ ++E + R E + +E + Q ++++ + +Q + E++
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-EEEE 665
Query: 245 HKCEELLNAQHQ---RLLEMLDTEKELLKEKIKEAL--------IQQSQEQKEILEKCLE 293
+ E+ L +H+ R E+ + E+E +E+IK + + Q ++ + +
Sbjct: 666 ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRK 725
Query: 294 EERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERE----LWKTEHAKDQE 349
+E QR ++ + EK +++ L+ EEER + ++ E+R W+ E ++
Sbjct: 726 QEGQRRRQE-----QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 350 KVSQEIQKAIQEQRKISQETVKAAIIEEQ---KRSEKAVEEAVKRTRDELIEYIKEQKRL 406
+ + ++EQR+ + E++ + EK +R R++ +++++E+++L
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 407 DQVIRQRSLSSLE 419
+ R + L E
Sbjct: 841 QRRERAQQLQEEE 853
Score = 57.8 bits (138), Expect = 2e-08
Identities = 58/292 (19%), Positives = 140/292 (47%), Gaps = 18/292 (6%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q++ +++ + E +Q+++++ E + + + + +EQ+ Q +E Q +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
+Q+L ++ E + + Q +QQ+ E+Q E++ H+ + +
Sbjct: 391 REQQLRREQQLRRE------QQLRREQQLRREQQLRR-EQQLRREQEEERHEQKHEQERR 443
Query: 255 HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAV 314
QRL + ++ LK + +E + + +K+ L++ EEER+ L + E++
Sbjct: 444 EQRLKREQEERRDWLKRE-EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 315 KDAVLKVVEEERKNLE-KAHAEERELWKTEHAKDQEKVSQEIQK----AIQEQRKISQET 369
++ L+ +EER+ K EE L + ++ Q + QE ++ +E++++ QE
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIK--EQKRLDQVIRQRSLSSLE 419
+ + EQ E+ ++ +KR + + +K +++RL+Q +++ + LE
Sbjct: 563 REQRLKREQ---EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Score = 57.4 bits (137), Expect = 3e-08
Identities = 67/280 (23%), Positives = 133/280 (47%), Gaps = 20/280 (7%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q++ E++ EE+ QR ++ + L E+ + L++ + + QE Q +L+E+
Sbjct: 823 QRREREKELQFLEEEEQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQ-QVEAIEKQYISAIEKQAHKCEELLNA 253
K+ + AL + + + LLQ ++ Q E EK+ E+Q + E+L
Sbjct: 882 RKRRRHTLY--AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 254 QHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEA 313
+ Q L E + EK +E+ ++ + +QKE E+ L EE ++ + E+E
Sbjct: 940 EEQLLRE--EREKRRRQERERQYRKDKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEE 995
Query: 314 VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQR--KISQETVK 371
++ +++ EER+ R+ W+ ++ K E + QE ++ ++E+R + QE +
Sbjct: 996 LQQEEEQLLREEREK------RRRQEWERQYRKKDE-LQQEEEQLLREEREKRRLQERER 1048
Query: 372 AAIIEEQKRSEKAV---EEAVKRTRDELIEYIKEQKRLDQ 408
EE+ + E+ EE R R EL ++++ L Q
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Score = 57.4 bits (137), Expect = 3e-08
Identities = 69/337 (20%), Positives = 151/337 (44%), Gaps = 43/337 (12%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL--EKGFLKEKEQEAISFQD 186
+S + +K E +++ E E++ ++++ + E+H E+ L+E+E++ + Q+
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 187 RYKELQEKHKQ--ELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQA 244
R ++ E+ +Q E RK + L E K L + +QQ+ ++Q E+Q
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE---EQQLHRQQRQRKFLQEEQQ 1539
Query: 245 HKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILE-----------KCLE 293
+ +E + Q E++L +E+ ++ L +Q +++K LE K +E
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599
Query: 294 EERQRNKEALVSAAKLEKEAV-----------KDAVLKVVEEERKNLEKAHAEERELWKT 342
+E+Q ++ + E++ ++ L E +RK LE+ R+ +
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 343 EHAKDQEKVSQEIQKAIQE-----------QRKISQETVKAAIIEEQKRSEKAVEEAVKR 391
+ D+++ +E ++ +QE RK +E + + Q+R K ++E +
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ---LRRQERERKFLQEEQQL 1716
Query: 392 TRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
R EL +E+++L Q Q L E + +++
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Score = 56.2 bits (134), Expect = 6e-08
Identities = 68/297 (22%), Positives = 143/297 (48%), Gaps = 27/297 (9%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+LQ++ + ++ +EE+Q + ++ E+ + LE+ + KE+E + Q +E +
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERET--RRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLN 252
++ +QE E + E +E + L + K++ + +E+QY E Q + E+LL
Sbjct: 1100 KRRRQERERQCREEEELQQ---EEEQLLREEREKRRRQELERQYREEEEVQQEE-EQLLR 1155
Query: 253 AQHQRL----LEMLDTEKELLKEKIKEALIQQSQEQKEILEKCL--EEERQRNK------ 300
+ ++ LE E+E L+++ ++ L ++ +++++ E+ EEE QR K
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 301 -EALVSAAKLEKEAVKDAVL---KVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
E S K + E K+ + KV + R+N + E+ +L + +D + + E Q
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 357 KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTR-----DELIEYIKEQKRLDQ 408
+ +EQ + + EE++ + +EA +R R +L+ +E+KR Q
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/287 (21%), Positives = 141/287 (49%), Gaps = 18/287 (6%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEK-HNVLEKGFLKEKEQEAISFQDRYKEL 191
QL+ + S +++ + E++++ +Q+ ++ + E+ L+ +EQ+ +DR K
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR-KSQ 1315
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
+EK E K + E + LLQ +Q + E+ E+ H+ +
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILE-KCLEEERQRNKEALVSAAKLE 310
+ ++ L + E++ LKE+ + ++ Q+ ++ + K EEE+Q +++ + E
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435
Query: 311 KEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETV 370
++ V+ E ERK LE EE++L + H K +E+ +++ + +EQ+ QE
Sbjct: 1436 EQQVRRQ-----ERERKFLE----EEQQLRQERHRKFREE--EQLLQEREEQQLHRQERD 1484
Query: 371 KAAIIEEQ----KRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+ + EEQ + ++ E R+++ ++++E+++L + RQR
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Score = 55.1 bits (131), Expect = 1e-07
Identities = 55/275 (20%), Positives = 136/275 (49%), Gaps = 23/275 (8%)
Query: 143 IKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDM 202
+KL+ E +Q+ +++ + E+ E+ +++E+E + Q R + Q+ +++ E
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL--QQRLRSEQQLRREQEERR 546
Query: 203 RKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEK--QAHKCEELLNAQHQRLLE 260
+ + +E K L Q +Q+++ +++ + K + + + L Q +RL +
Sbjct: 547 EQL------LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 261 MLDTE--KELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV 318
L E + L +E+ +E +++ + ++E ++ L+ E Q +E + E++ ++
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ--EERRQQQLRREQQERREQR 658
Query: 319 LKVVEEERK---NLEKAHAEER---ELWKTEHAKDQEKVSQEIQK---AIQEQRKISQET 369
LK EEE + L++ H EER EL + E + +E++ I K ++ + Q
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQK 404
V + +++ + + +E +R R+ +++ +E++
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Score = 54.3 bits (129), Expect = 2e-07
Identities = 68/306 (22%), Positives = 138/306 (45%), Gaps = 36/306 (11%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLM----EKHNVLEKGFLKEKEQEAISFQDRYKE 190
+Q++ E K EEE Q +Q+ E + ++ E+ L+E E++ + Q+R ++
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 191 L---------QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIE 241
QE+ ++ L++ ++ + L E + L Q + ++Q+ E+ E
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752
Query: 242 KQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEER----- 296
+Q E + Q E++L +E+ ++ L Q ++K E+ L +ER
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812
Query: 297 ---QRNKEALVSAAKLEKEAVKDAVLKV------VEEERKNLEKAHAEERELWKTEHAKD 347
QR+ + +L+ E + + + EE+ EK+ EE+ELW+ E K
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Query: 348 QEKVSQEI-QKAIQEQRKISQETVKAAIIEEQ--KRSEKAVE------EAVKRTRDELIE 398
+++ +++ ++ I+ Q+K Q + I+ Q K + +E +V L E
Sbjct: 1873 RQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYE 1932
Query: 399 YIKEQK 404
YI+EQ+
Sbjct: 1933 YIQEQR 1938
Score = 52.0 bits (123), Expect = 1e-06
Identities = 51/264 (19%), Positives = 127/264 (48%), Gaps = 15/264 (5%)
Query: 146 KVSEEEKQRIK-QDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRK 204
+ EE+ Q K + E ++ + + L+ + + Q + +E Q++ QE E+
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 205 AGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDT 264
E + + +E K + +Q+ E++ + +E+Q + E Q Q+ L
Sbjct: 247 RKRETV-LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR---- 301
Query: 265 EKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEE 324
++ L+ K +E +Q +E++E E+ ++E +R ++ + ++E + + + EE
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQL----RREQEERREQQLRREQEE 357
Query: 325 ERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKA 384
ER+ ++ E+ E + + + ++++ +E Q ++Q + Q+ + E+Q R E+
Sbjct: 358 ERRE-QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR----EQQLRREQQ 412
Query: 385 VEEAVKRTRDELIEYIKEQKRLDQ 408
+ + R++ + +E++R +Q
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQ 436
Score = 52.0 bits (123), Expect = 1e-06
Identities = 67/313 (21%), Positives = 145/313 (46%), Gaps = 44/313 (14%)
Query: 132 IQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLK----EKEQEAISFQDR 187
++ +++ LE +LK EE++R ++ E E+ K + + E EA + Q +
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 188 Y-----KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQ------QVEAIEK-- 234
K+ ++ +QE E+ R+ L +E Q +Q Q +A EK
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 235 ---QYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKC 291
Q +SA + E L A+ ++ E ++ L +E+ KE +Q +E+++ L+
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQRE----QRFLPEEEEKEQRRRQRREREKELQ-F 833
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKD---- 347
LEEE Q + + E++ +++ ++ER+ ++ +++ W+ E +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQE------DQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 348 --------QEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEY 399
QE++ +E Q +E+ ++ +E + +EQ+R + EE +++ ++L+
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE-EEQLQQEEEQLLRE 946
Query: 400 IKEQKRLDQVIRQ 412
+E++R + RQ
Sbjct: 947 EREKRRRQERERQ 959
Score = 49.7 bits (117), Expect = 5e-06
Identities = 75/374 (20%), Positives = 160/374 (42%), Gaps = 45/374 (12%)
Query: 72 ENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSN 131
E A + IPK Q Q + D + K G + E S
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEA--DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 132 IQLQQKISSLEIKLKVSEEEKQRI------KQDVESLMEKHNVLEKGFLKEKEQEAISFQ 185
+Q Q++ E + +EE+QR + + +S + + + L+E+ + + +
Sbjct: 746 LQWQEE----ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801
Query: 186 DRYKELQ-----EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAI 240
+R + Q E+ K++ R+ + L + +E + L + QQ++ E +
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE-EQLQRRERAQQLQEEE----DGL 856
Query: 241 EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKI--KEALIQQSQEQKEILEKCLEEERQR 298
++ + + Q+ L+ E++ + + K AL +Q ++++++L++ EEE QR
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE-EEEELQR 915
Query: 299 NKEALVSAAKLEKEAVKDAVLKVVEEE--RKNLEKAHAEERELWKTEHAKDQEKVS---- 352
+ + E++ ++ L+ EE+ R+ EK +ERE + K Q+K
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 353 --------QEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE------EAVKRTRDELIE 398
QE +K +E+ ++ QE + E +KR + E + +++ ++L+
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 399 YIKEQKRLDQVIRQ 412
+E++RL + RQ
Sbjct: 1036 EEREKRRLQERERQ 1049
Score = 47.4 bits (111), Expect = 3e-05
Identities = 56/296 (18%), Positives = 132/296 (44%), Gaps = 35/296 (11%)
Query: 133 QLQQKISSLEI-KLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKEL 191
+L+Q++ E+ +L+ E +QR+K++ E + LK +EQE Q +E
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKRE-----EPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
QE+ +Q L+ +E + L+ +K++ E E++ E++ + E +
Sbjct: 652 QERREQRLKR-------------EEEEERLEQRLKREHEE-ERREQELAEEEQEQARERI 697
Query: 252 NAQHQRLLEMLDTEKELLKEKI-----KEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
++ + L++E + + K+ K+ ++ QEQ+E + E E Q +E
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR-RESELQWQEEERAHR 756
Query: 307 AKLEKEAVKDAVLKVVEEERKNLEKAHAE---------ERELWKTEHAKDQEKVSQEIQK 357
+ E+E +D + EE+ + ER+L E + +++ E ++
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 358 AIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
Q +R+ + + +EE+++ ++ + ++ ++ +E++R + R +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/167 (20%), Positives = 78/167 (46%), Gaps = 15/167 (8%)
Query: 257 RLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKD 316
R LE ++ K + +E + + +EQ E E+ + +RQR E L +++ ++
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR----QRQEWQE 182
Query: 317 AVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQ----EIQKAIQEQRKISQETVKA 372
+ EEE+ K H +TE D+E++ + E+++ +E+++ + +
Sbjct: 183 REERRAEEEQLQSCKGH-------ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 373 AIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
+ +E++ E E V R +E ++ + Q++ + + L LE
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Score = 31.6 bits (70), Expect = 1.5
Identities = 38/176 (21%), Positives = 81/176 (46%), Gaps = 19/176 (10%)
Query: 256 QRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLE-----------EERQRNKEALV 304
QR + ++ L E +++ Q+ EQ++ + E EER+ +E L
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 305 SAAKLEKEAVKDAV----LKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI- 359
S E E D +++E RK E+ + RE +++EK ++ + +
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 360 QEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+E+ K+ +E + + EE+++ K + ++R R E E +++ R +Q +R++
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE-EEQQQQRLRREQQLRRK 309
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.8 bits (177), Expect = 6e-13
Identities = 71/305 (23%), Positives = 157/305 (51%), Gaps = 26/305 (8%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRY 188
+++ +L++K + L+ KL++ E EK I+ +V+ L K LE+ L +Q+ + D
Sbjct: 202 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERAKLLLPQQQLQAEADHL 258
Query: 189 -KELQ--------EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQY--I 237
KELQ + + EL + E +E + +++Q E I +Q +
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKM 318
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ 297
E+ + EE + Q + + E + +EL ++ ++ I++ +E+++ EK E+E++
Sbjct: 319 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 378
Query: 298 RNKEALVSAAKLEKEAVKDAVLKVVEEE---RKNLEKAHAEERELWKTEH--AKDQEKVS 352
+ +EA + ++E +++ K+ E+E ++ EK +E ++W+ E + +EK+
Sbjct: 379 QEQEAKMWR---QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 353 QEIQKAIQEQRKISQETVKAAIIEE--QKRSEKAVEEAVKRTRDE--LIEYIKEQKRLDQ 408
++ +K ++++KI ++ K EE Q++ EK E+ K E + E ++ +R ++
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495
Query: 409 VIRQR 413
IR++
Sbjct: 496 KIREQ 500
Score = 67.0 bits (162), Expect = 3e-11
Identities = 63/278 (22%), Positives = 144/278 (51%), Gaps = 25/278 (8%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQ--DRYKELQ 192
++KI E K+ +E++++I++ E + + ++ + K + QE + ++ ++ +EL+
Sbjct: 294 EEKIQEREEKI---QEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 350
Query: 193 EK-HKQE-LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
EK H+QE + + + E I E + ++ + +Q E I +Q E++ + EE+
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ-----EEKIREQEEM 405
Query: 251 LNAQHQRLLE----MLDTEKELLKEKIK-----EALIQQSQEQKEILEKCLEEERQRNKE 301
+ Q +++ E M + E+E+ +++ K E + +Q ++ +E EK E+E ++
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 465
Query: 302 ALVSAAKLEKEAVKDAVLKVVEEE-RKNLEKAHAEERELWKTEHA-KDQEKVSQEIQKAI 359
+ K ++A ++ EE+ R+ EK +E+++ + E ++QE++ QE ++ +
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525
Query: 360 --QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDE 395
QE++ QE E+ +R E+ + E R R +
Sbjct: 526 WEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563
Score = 64.7 bits (156), Expect = 2e-10
Identities = 69/299 (23%), Positives = 150/299 (50%), Gaps = 30/299 (10%)
Query: 128 NVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR 187
N N Q ++K+ E K++ EE+ Q ++ + EK E+ + EKE++ R
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEE-MMWEKEEK----MRR 334
Query: 188 YKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKC 247
+E+ + ++++ ++ + HE I E K + +++Q + E+ E + +
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ------EAKMWRQ 388
Query: 248 EELLNAQHQRLLE---MLDTEKELLKEKIKEALIQQS----QEQKEILEKCLEEERQRNK 300
EE + Q +++ E M+ ++E + E+ E + + QEQ+E + + E+ R++ K
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQ--EEKMWEQEEEMQEQEEKMRRQEEKIREQEK 446
Query: 301 EALVSAAKL--EKEAVKDAVLKVVEEERKNLEK----AHAEERELWKTEHAKDQEKVSQE 354
+ K+ ++E +++ K+ E+E K E+ EE+ + E ++QEK +E
Sbjct: 447 KIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE 506
Query: 355 IQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
++ I+EQ ++ QE + +E+K E+ EE ++ +++ +E+K +Q +R R
Sbjct: 507 QEEKIREQEEMMQEQEEKMWEQEEKMCEQ--EEKMQEQEEKMRR--QEEKMREQEVRLR 561
Score = 59.3 bits (142), Expect = 7e-09
Identities = 56/277 (20%), Positives = 140/277 (50%), Gaps = 26/277 (9%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEA-ISFQDRYKEL 191
+LQ ++ E+ ++++++++++ + E + E+ +++ K +EQE + Q+
Sbjct: 268 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
+E+ + E+M E + + E K Q +++Q E ++Q I +Q + E+
Sbjct: 328 KEEKMRRQEEMMWEKEEKIREL--EEKMHEQEKIREQEE--KRQEEEKIREQEKRQEQ-- 381
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEK 311
A+ R E + ++E ++E+ +E + +Q ++ E EK E+E + ++ + ++
Sbjct: 382 EAKMWRQEEKIREQEEKIREQ-EEMMQEQEEKMGEQEEKMWEQEEEMQEQE--EKMRRQE 438
Query: 312 EAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVK 371
E +++ K+ E+E K E+ + + +EK+ ++ K +++ K+ ++
Sbjct: 439 EKIREQEKKIREQEEKIREQEEMMQEQ---------EEKMGEQEGKMCEQEAKMQEQE-- 487
Query: 372 AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
E+ +R E+ + E K+ R++ E I+EQ+ + Q
Sbjct: 488 ----EKMRRQEEKIREQEKKIREQ-EEKIREQEEMMQ 519
Score = 58.9 bits (141), Expect = 9e-09
Identities = 56/264 (21%), Positives = 131/264 (49%), Gaps = 25/264 (9%)
Query: 135 QQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
++KI E K++ EE +++++++ E + EK + + K EQE I Q+ ++
Sbjct: 308 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 367
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+EK + E ++ EA +E + +++Q E +++Q E++ E+
Sbjct: 368 EEEKIR---EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424
Query: 251 LNAQHQRLLEMLDTEKELLKEKIKEALIQQSQ--EQKEIL----EKCLEE-----ERQRN 299
Q Q E + ++E ++E+ K+ Q+ + EQ+E++ EK E+ E++
Sbjct: 425 EEMQEQE--EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK 482
Query: 300 KEALVSAAKLEKEAVKDAVLKVVEEE---RKNLEKAHAEERELWKTEH--AKDQEKVSQE 354
+ + ++E +++ K+ E+E R+ E +E ++W+ E + +EK+ ++
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 542
Query: 355 IQKAIQEQRKISQETVKAAIIEEQ 378
+K +++ K+ ++ V+ EE+
Sbjct: 543 EEKMRRQEEKMREQEVRLRQQEEK 566
Score = 55.8 bits (133), Expect = 7e-08
Identities = 68/295 (23%), Positives = 140/295 (47%), Gaps = 28/295 (9%)
Query: 133 QLQQKISSLEIKLKVSEE--EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
+L+Q +S++ + K ++ E+ ++D SL N + LKEK + Q++ +
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK---LQEKL-Q 219
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALL-QSSVKQQVEAIEKQYISAIEKQAHKCEE 249
L E K E++ + L ++ K LL Q ++ + + + K+ S K + EE
Sbjct: 220 LVESEKSEIQ----LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 275
Query: 250 LLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL 309
N RL + + + +EKI+E ++ QEQ+E K E+E + ++ + K
Sbjct: 276 --NELWNRLNQQQEEKMWRQEEKIQERE-EKIQEQEE---KIREQEEKMRRQEEMMWEKE 329
Query: 310 EKEA-------VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
EK K+ ++ +EE+ EK +E + + E ++QEK ++ K +++
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 363 RKISQETVK----AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
KI ++ K +++EQ+ EE + +E+ E ++ +R ++ IR++
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Score = 50.1 bits (118), Expect = 4e-06
Identities = 50/231 (21%), Positives = 113/231 (48%), Gaps = 20/231 (8%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
++KI LE K+ E+++I++ E E+ + E+ +E+E + +++ +E +EK
Sbjct: 343 EEKIRELEEKM----HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 398
Query: 195 HKQELEDMR----KAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQY--ISAIEKQAHKC 247
+++ E M+ K G + + E + Q +++Q E I +Q I E++ +
Sbjct: 399 IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 458
Query: 248 EELLNAQHQRLLE----MLDTEKELLKEKIK-----EALIQQSQEQKEILEKCLEEERQR 298
EE++ Q +++ E M + E ++ +++ K E + +Q ++ +E EK E+E
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Query: 299 NKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQE 349
++ + EK ++ ++ EE+ + E+ E+ + + K QE
Sbjct: 519 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 72.8 bits (177), Expect = 6e-13
Identities = 65/292 (22%), Positives = 149/292 (51%), Gaps = 20/292 (6%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
++KI LE K+ E+++I++ E E+ + E+ +E+E + +++ +E +EK
Sbjct: 437 EEKIRELEEKM----HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 195 HKQELEDMRKAG---HEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
+++ E M + HE I +E + + +Q+ + E++ I +++ H+ EE +
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 252 NAQHQRLL----EMLDTEKELLKEKIK-----EALIQQSQEQKEILEKCLEEERQRNKEA 302
Q +++ +M D E+++ +++ K E + +Q ++ +E EK E+E ++
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612
Query: 303 LVSAAKLEKEAVKDAVLKVVEEE-RKNLEKAHAEERELWKTEHA-KDQEKVSQEIQKAI- 359
+ EK ++ ++ EE+ R+ EK +E+++ + E ++QE++ QE ++ +
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672
Query: 360 -QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVI 410
QE++ QE E+ +R E+ + E R R + + + Q+ L+ I
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 71.6 bits (174), Expect = 1e-12
Identities = 66/297 (22%), Positives = 153/297 (51%), Gaps = 28/297 (9%)
Query: 135 QQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVL--EKGFLKEKEQEAISFQDRY 188
++KI E K++ EE +++++++ E + EK + ++ + EKE++ R
Sbjct: 374 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK----MRRQ 429
Query: 189 KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQY-ISAIEKQAHKC 247
+E+ + ++++ ++ + HE I E K + +++Q + E++ + E++ +
Sbjct: 430 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 489
Query: 248 EELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ--RNKEALVS 305
EE + Q +++ EK +EKI+E +Q QE+ E+ + E+ + R KE +
Sbjct: 490 EEKIREQEEKMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE 547
Query: 306 AAKLEKEAVKDAVLKVVEEERK---NLEKAHAEERELWKTEHA-KDQEKVSQEIQKAIQE 361
++E ++ K+ +E K EK +E ++W+ E ++QE+ +E ++ I+E
Sbjct: 548 ----QEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE 603
Query: 362 QRKISQETVKAAIIEEQKRSEKAV-----EEAVKRTRDELIEYIKEQKRLDQVIRQR 413
Q +++QE + +E+K E+ EE ++R +++ E K+ + ++ IR++
Sbjct: 604 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 660
Score = 65.5 bits (158), Expect = 9e-11
Identities = 65/302 (21%), Positives = 150/302 (49%), Gaps = 50/302 (16%)
Query: 134 LQQKISSLEIKLKVSEEEKQ---RIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
L +++ S+ KL+ EE + R+ Q E M + EK ++E E++ +++ +E
Sbjct: 331 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQE--EK--IQEWEEKIQEQEEKIRE 386
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+EK +++ E MR+ + + ++ E + +Q E+ + EE
Sbjct: 387 QEEKIREQEEKMRRQ----------------EEMMWEKEEKMRRQ-----EEMMWEKEEK 425
Query: 251 LNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLE 310
+ Q + + E + +EL ++ ++ I++ +E+++ EK E+E+++ +EA + +
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR---Q 482
Query: 311 KEAVKDAVLKVVEEERK---NLEKAHAEER-----------ELWKTEH-AKDQEKVSQEI 355
+E +++ K+ E+E K EK H +E+ E+W+ E ++QE++ ++
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 356 QKAIQEQRKISQETVKAAIIEE----QKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIR 411
+K +++ KI ++ K EE Q+ + EE V R +++ E ++ + ++ IR
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Query: 412 QR 413
++
Sbjct: 603 EQ 604
Score = 62.4 bits (150), Expect = 8e-10
Identities = 71/293 (24%), Positives = 143/293 (48%), Gaps = 40/293 (13%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRY 188
+++ +L++K + L+ KL++ E EK I+ +V+ L K LE+ L +Q+ + D
Sbjct: 275 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERAKLLLPQQQLQAEADHL 331
Query: 189 -KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKC 247
KELQ + L V+E + L + + QQ E EK + E++ +
Sbjct: 332 GKELQSVSAK------------LQAQVEENE--LWNRLNQQQE--EKMWRQ--EEKIQEW 373
Query: 248 EELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALV--S 305
EE + Q +++ E +EKI+E + ++++ + EK EE+ R +E ++
Sbjct: 374 EEKIQEQEEKIREQ--------EEKIREQEEKMRRQEEMMWEK---EEKMRRQEEMMWEK 422
Query: 306 AAKLEKEA----VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE 361
K+ ++ K+ ++ +EE+ EK +E + + E ++QEK ++ K ++
Sbjct: 423 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 362 QRKISQETVKAAIIEEQK-RSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+ KI ++ K EE+ R E+ + E K +E + +E R ++ IR++
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 535
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 72.0 bits (175), Expect = 1e-12
Identities = 73/298 (24%), Positives = 149/298 (50%), Gaps = 27/298 (9%)
Query: 119 VDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKE 178
+ + E+ I+ Q+K E K+ EE +I++ E + E+ + + K E
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---KIREQEEKIREQEKKMWRQEEKIHE 448
Query: 179 QEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
QE I +++ +E +E +QE E +R E I + K Q +++Q E + +Q
Sbjct: 449 QEKIREEEKRQEQEEMWRQE-EKIR----EQEEIWRQKEKMHEQEKIRKQEEKVWRQ--- 500
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
E++ H EE + Q +++ + +E +EKI+E ++ +EQ+E++++ +EE+
Sbjct: 501 --EEKMHDQEEKIREQEEKMWRQEEKIREQ-EEKIREQE-EKIREQEEMMQE--QEEKMG 554
Query: 299 NKEALVSAAKLEKEAVKDAVLKVVEEE---RKNLEKAHAEERELWKTEH-AKDQEKVSQE 354
+E + E+E ++ K+ E+E R+ EK +E ++W+ E ++QE++ QE
Sbjct: 555 EQEEKMQ----EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 355 IQKAI--QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVI 410
++ + QE++ QE E+ +R E+ + E R R + + + Q+ L+ I
Sbjct: 611 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 71.6 bits (174), Expect = 1e-12
Identities = 62/285 (21%), Positives = 151/285 (52%), Gaps = 15/285 (5%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
++KI LE K+ E+++I++ E E+ + E+ +E+E + +++ +E +EK
Sbjct: 376 EEKIRELEEKM----HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 195 HKQELEDMRKAG---HEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
+++ + M + HE I +E + + +Q+ + E++ I +++ H+ E++
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491
Query: 252 NAQHQ--RLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL 309
+ + R E + ++E ++E+ +E + +Q ++ +E EK E+E + ++ + +
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQ-EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE 550
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKT-EHAKDQEKVSQEIQKAIQEQRKISQE 368
EK ++ ++ E+ R+ EK +E ++ + E ++QE+ E ++ I+EQ ++ QE
Sbjct: 551 EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 369 TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+ +E+K E+ EE ++ +++ +E+K +Q +R R
Sbjct: 611 QEEKMWEQEEKMCEQ--EEKMQEQEEKMRR--QEEKMWEQEVRLR 651
Score = 61.2 bits (147), Expect = 2e-09
Identities = 73/295 (24%), Positives = 145/295 (49%), Gaps = 44/295 (14%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRY 188
+++ +L++K + L+ KL++ E EK I+ +V+ L K LE+ L +Q+ + D
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERAKLLLPQQQLQAEADHL 270
Query: 189 -KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKC 247
KELQ + L V+E + L + + QQ E EK + E++ +
Sbjct: 271 GKELQSVSAK------------LQAQVEENE--LWNRLNQQQE--EKMWRQ--EEKIQEW 312
Query: 248 EELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALV--- 304
EE + Q +++ E +EKI+E + ++++ + EK EE+ R +E ++
Sbjct: 313 EEKIQEQEEKIREQ--------EEKIREQEEKMRRQEEMMWEK---EEKMRRQEEMMWEK 361
Query: 305 --SAAKLEKEA-VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE 361
+LE+ K+ ++ +EE+ EK +E + + E ++QEK ++ K ++
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 362 QRKISQETVKAAIIEEQK---RSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+ KI ++ K I E++K R E+ + E K +E + +E R ++ IR++
Sbjct: 422 EEKIREQEEK--IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 70.9 bits (172), Expect = 2e-12
Identities = 78/313 (24%), Positives = 149/313 (47%), Gaps = 29/313 (9%)
Query: 145 LKVSEEEKQRIKQDVESLM-EKHNVLEKGFLKEKEQEAISFQDRYKELQEK-----HKQE 198
L +S EE +RIK L E+ ++ F KEKE + R K +++K + ++
Sbjct: 102 LIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKK 161
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---H 255
L D+ + E ++ L +++++ + K ++A KC + +AQ
Sbjct: 162 LSDLEEVAKERAQNLLQRANKLRMEQ-EEELKDMSKIILNA------KCHAIRDAQILEK 214
Query: 256 QRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVK 315
Q++ + LDTE++ L +++ E Q+S +++E LE+ EER R + +V ++EK +
Sbjct: 215 QQIQKELDTEEKRL-DQMMEVERQKSIQRQEELERKRREERIRGRRQIVE--QMEKNQEE 271
Query: 316 DAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET--VKAA 373
++L E+R+ ++ E E + E KD E+ Q+ K E ++I+ E KA
Sbjct: 272 RSLL---AEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAE 328
Query: 374 IIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRL-----DQVIRQRSLSSLELFLSCAQKQ 428
++ ++K +++ V E K+ E+ EQ+R+ ++ R R++ Q
Sbjct: 329 LLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDA 388
Query: 429 LSALIATEPVDIE 441
L A E D E
Sbjct: 389 LRAKRNQEVADRE 401
Score = 65.5 bits (158), Expect = 9e-11
Identities = 81/343 (23%), Positives = 158/343 (46%), Gaps = 41/343 (11%)
Query: 119 VDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKE 178
+D E + ++ Q+ I E + EE+ R ++ + MEK+ +++E
Sbjct: 221 LDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE 280
Query: 179 QEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEK---- 234
QE + ++LQE+ L+DM + + L + E K + + KQ+ E + +
Sbjct: 281 QEKEQMLEYMEQLQEED---LKDMERRQQQKLKMQA-EIKRINDENQKQKAELLAQEKLA 336
Query: 235 -QYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILE---- 289
Q + K+ E A+ +R+ + EKE+ + + + Q Q +++ L
Sbjct: 337 DQMVMEFTKKKMAREAEFEAEQERIRR--EKEKEIARLRAMQEKAQDYQAEQDALRAKRN 394
Query: 290 --------KCLEEERQRNK---EALVSAAKLEKEAVKDAVLKV-VEEERKNLEKAHAEER 337
+ E+E R K EA + ++LE+ A K+ L V V+ +R E+ +R
Sbjct: 395 QEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQR 454
Query: 338 ELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVK-----AAIIEEQKRSEKAVEEAVKRT 392
E + E ++++K + +Q A + +R++ + K A EE +R + EEA KR
Sbjct: 455 EQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLK---EEAQKRR 511
Query: 393 RDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSALIAT 435
E I+ IK +K+L+++ R+ E + A+++ + L AT
Sbjct: 512 --ERIDEIK-RKKLEEL---RATGLPEKYCIEAERKANILPAT 548
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 70.1 bits (170), Expect = 4e-12
Identities = 73/336 (21%), Positives = 165/336 (49%), Gaps = 31/336 (9%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEK--HNVLEKGFLKEKEQEAISFQD 186
V +Q QQ ++LE + E +++ +++ MEK ++ L+EK+ + +Q
Sbjct: 591 VQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ- 649
Query: 187 RYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVK---QQVEAIEKQYISAIEKQ 243
++++++++Q++ +++ + + ++ ++ A S V+ +++E +EKQ +A +
Sbjct: 650 -LEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEH 708
Query: 244 AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQ-QSQEQKEILEKCL--EEERQR-- 298
++ +E Q + +M E K++E LI SQ +++++E L EEE+QR
Sbjct: 709 ENQIQEFKKRDAQVIADM-----EAQVHKLREELINVNSQRKQQLVELGLLREEEKQRAT 763
Query: 299 -NKEALVSAAKLEKEAVKDAVLKV-VEEERKNLEKAHAEERELWK--TEHAKDQEKVSQE 354
E +V+ K E E +K + K E LEKA+++ +++ K T+ ++ E
Sbjct: 764 REHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAE 823
Query: 355 IQKAIQE------QRKISQET----VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQK 404
+Q I Q++++ E V+ +E+K+ + ++A+K +DEL + +
Sbjct: 824 LQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVR 883
Query: 405 RLDQVIRQRSLSSLELFLSCAQKQLSALIATEPVDI 440
++ ++ + L S E Q+ + L P +
Sbjct: 884 CAEKKLQHKELESQEQITYIRQEYETKLKGLMPASL 919
Score = 57.0 bits (136), Expect = 3e-08
Identities = 73/342 (21%), Positives = 148/342 (43%), Gaps = 50/342 (14%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+L+Q + L+ +L+ SE ++++ +D E+ + K ++K + S D+ KE
Sbjct: 508 ELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDT 567
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSS------VKQQVEAIEKQYISAIEKQAHK 246
+K + E+ K E L+ + + + Q + K+QVE ++ + +++Q K
Sbjct: 568 QKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEK 627
Query: 247 CE-------ELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEK--------C 291
E L Q + L L+ ++ +++I E ++ QE+ +L++
Sbjct: 628 VEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLV 687
Query: 292 LEEERQ-RNKEALVSAAKLEKE--------------AVKDAVLKVVEEERKNLEKAHAEE 336
+ ER+ N E + AA +E E A +A + + EE N+ ++
Sbjct: 688 RDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQ 747
Query: 337 -------RELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAV 389
RE K ++ E V ++ KA E+ KI + AA +E +E+A
Sbjct: 748 LVELGLLREEEKQRATREHEIVVNKL-KAESEKMKIELKKTHAA------ETEMTLEKAN 800
Query: 390 KRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+ + EY ++ + Q+I + + L +Q+QL+A
Sbjct: 801 SKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAA 842
Score = 49.7 bits (117), Expect = 5e-06
Identities = 59/313 (18%), Positives = 148/313 (47%), Gaps = 32/313 (10%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYK-EL 191
+L++K+ +L +V E K+ +++ + E+ ++K A++ ++ K +L
Sbjct: 314 KLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDL 373
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSS--VKQQVEAIEKQYISAIEKQAHKCEE 249
Q++H + ++++ + + L+ + EY A QS+ + +++EA +Q E + ++
Sbjct: 374 QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQK 433
Query: 250 LL--NAQHQRLLEMLDTEKELLK------EKIKEALIQQSQEQKEILEKCLEEERQRNKE 301
L+ A+ +R ++ +E + +K K K+ L+ ++ ++L Q +
Sbjct: 434 LIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLL--------QTKYD 485
Query: 302 ALVSAAKLEKEAVKDAVLKVVEEERKNL--EKAHAEERELWKTEHAKDQEKVSQEIQKAI 359
A ++ K E ++EE +N+ K +E EL + + +DQE Q + +
Sbjct: 486 ADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHL 545
Query: 360 QEQRKISQETVKAAIIEEQKRSEKAV---EEAVKRTRDELIEYIKEQK--------RLDQ 408
+ + +++ + + ++ ++K + EEA+K ++L + Q+ L++
Sbjct: 546 KHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEE 605
Query: 409 VIRQRSLSSLELF 421
RQ L+S +++
Sbjct: 606 FKRQVELNSEKVY 618
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 69.7 bits (169), Expect = 5e-12
Identities = 78/347 (22%), Positives = 161/347 (46%), Gaps = 55/347 (15%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLE------KGFLKEKEQEAISFQDR 187
+ Q + LE+ + EK+ + +++ E+ + LE + L+EKEQE + +++
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 188 YKELQEKHKQELEDMRKAGHEALSIIVDEYKALL--QSSVKQQVEAIEKQYISAIE--KQ 243
E + +L+++ +E ++ + ++ +A + ++ QVE +E + ++ +
Sbjct: 2436 SSTAMEMLQTQLKEL----NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDE 2491
Query: 244 AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEA--LIQQSQEQKEILEKCLEEE------ 295
A +L + L++ ++ K+ L++K +E L Q Q+Q++++ K + E
Sbjct: 2492 AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW 2551
Query: 296 RQRNKEALVSAAKLE--------KEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKD 347
+++N E +LE K A L+V++ KNLE E EL K +
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLEN----ELELTKMDKMSF 2607
Query: 348 QEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEK--------AVEEAVKRTRDELIEY 399
EKV++ K + QR++ + K A ++E+ EK + E +K ++D+L E
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Query: 400 IKEQKRL---------DQVIRQ----RSLSSLELFLSCAQKQLSALI 433
E L DQV ++ ++ +L L A+K+ AL+
Sbjct: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL 2714
Score = 58.2 bits (139), Expect = 1e-08
Identities = 79/356 (22%), Positives = 157/356 (44%), Gaps = 60/356 (16%)
Query: 111 KSNGTIALVDDSEDPGA----NVSNIQLQQKISSLEIKLKVSEEEK-------QRIKQDV 159
K + + D+S P N +L+ KI+ LE++L+ E+E Q ++ +
Sbjct: 263 KRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQL 322
Query: 160 E----SLMEKHNVLEK--GFLKEKEQEAISFQDRYKELQEKHKQELEDM------RKAGH 207
E L+EK VL K L + +Y L++K K+ ED+ ++
Sbjct: 323 EKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESAR 382
Query: 208 EALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQH-----QRLLEML 262
+L + E + Q + +Q + + I+ +A +EL A++ Q L+ L
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 263 DTEKELLKEKIK---------EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEA 313
+ K+ L+ ++ E Q SQ ++ L + +EE ++ N + + +E
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREV 502
Query: 314 VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKD--QEKVSQEIQKAI-QEQRKISQETV 370
+E E KN+++ + + + AK+ QE + +++Q+ I Q++ ++ E +
Sbjct: 503 CH------LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Query: 371 KAAIIEEQKRSE------KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLEL 420
K A+ + +K+ + K E +++ D+L + KE K L LS+LEL
Sbjct: 557 KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL--------LSALEL 604
Score = 57.0 bits (136), Expect = 3e-08
Identities = 80/304 (26%), Positives = 130/304 (42%), Gaps = 52/304 (17%)
Query: 131 NIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKE--QEAISFQDRY 188
N LQ + L+ K E E + K D S +EK N K KE E +E +
Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN---KMTAKETELQREMHEMAQKT 2632
Query: 189 KELQEKHKQELEDMRKAGHEALSIIVDEYKA---------LLQSSVKQQVEAIEKQYISA 239
ELQE+ E R AG L ++++E K+ L S +K+ ++ + K
Sbjct: 2633 AELQEELSGEKN--RLAGE--LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHK---DQ 2685
Query: 240 IEKQAHKCEELLNAQ---------HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEK 290
+EK+ EE+ Q HQ LL LDT K+ E IQ +E+ E+
Sbjct: 2686 VEKEGKVREEIAEYQLRLHEAEKKHQALL--LDTNKQY------EVEIQTYREKLTSKEE 2737
Query: 291 CLEEER------QRNKEALVSAAKL------EKEAVKDAVLKVVEEERKNLEKAHAEERE 338
CL ++ + +KE L ++ K E + K LK V + +K E+A + +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797
Query: 339 LWKTEHAKDQEK--VSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDEL 396
L K+ ++EK + +E+ + Q K TV ++E K ++E ++ E
Sbjct: 2798 LIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEA 2857
Query: 397 IEYI 400
EY+
Sbjct: 2858 DEYL 2861
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/309 (20%), Positives = 141/309 (45%), Gaps = 38/309 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+ +QK+ E + S+ ++ +++ +E + +++N+L K ++K +E + K ++
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLL-KSHSEQKAREVCHLEAELKNIK 513
Query: 193 E--KHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIE----KQYISAIEKQAHK 246
+ Q + KA + + ++ + LQ + QQ ++ K ++ +EKQ
Sbjct: 514 QCLNQSQNFAEEMKAKNTSQETMLRD----LQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 247 CEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
++LL + + ++ D K EK +AL+ + +K+ E E + ++ L S
Sbjct: 570 SQDLLKKREHHIEQLND--KLSKTEKESKALLSALELKKK------EYEELKEEKTLFSC 621
Query: 307 AKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK-------------DQEKVSQ 353
K E E +L +E E++NL+ KT+ K D+E +S
Sbjct: 622 WKSENE----KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV 677
Query: 354 EIQKA--IQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIR 411
EI+ + + + + ET K A +E Q+++E + ++ K + ++ + +++ +
Sbjct: 678 EIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEH 737
Query: 412 QRSLSSLEL 420
+ L S E+
Sbjct: 738 KLQLLSNEI 746
Score = 53.9 bits (128), Expect = 3e-07
Identities = 74/326 (22%), Positives = 155/326 (47%), Gaps = 41/326 (12%)
Query: 131 NIQLQQKISSLEIKLKVSEEEKQRI-------KQDVESLMEKHNVLEKGFLKEKEQEAIS 183
N L+ K+ +LE +L++SEE ++ + K +VE+L + + + LK E + ++
Sbjct: 2149 NDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARS-LKVFELDLVT 2207
Query: 184 F----QDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISA 239
++ K++QEK Q E L ++ +K+LL+ + +++ I+++ +A
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSE---------LDKLLSSFKSLLEEKEQAEIQ-IKEESKTA 2257
Query: 240 IEKQAHKCEELLNAQHQRLLEMLDTEKELLK--EKIKEALIQQSQEQKEILEKCLEE-ER 296
+E ++ +EL A + L ++E++K E+ + I++ + + +EK E
Sbjct: 2258 VEMLQNQLKELNEA-----VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHA-EERELWKTEHAKDQ-EKVSQE 354
K+ V E E D + VE + LE A +E + E++K + E + +
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAK 2372
Query: 355 IQKAIQEQRKISQETVKAAIIEE------QKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
I+ Q R + + V +E QK E+ E + + E I KEQ+++
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ- 2431
Query: 409 VIRQRSLSSLELFLSCAQKQLSALIA 434
++++S +++E+ L K+L+ +A
Sbjct: 2432 -MKEKSSTAMEM-LQTQLKELNERVA 2455
Score = 53.5 bits (127), Expect = 4e-07
Identities = 96/407 (23%), Positives = 174/407 (42%), Gaps = 55/407 (13%)
Query: 53 RDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPK-AQIQQSTHTHLDISLFPLGLTDE- 110
++ + + LSSD + TH + Q++ K +Q T L+ + L E
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKL--QSLEKDSQALSLTKCELENQIAQLNKEKEL 2067
Query: 111 ---KSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVS--EEEKQRIKQDVESLMEK 165
+S A + +S+ NVS + E L++S +EE ++++ +E L +
Sbjct: 2068 LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVR 2127
Query: 166 HNVLEKGFL------KEKEQEAISFQDRYKELQ-----------------EKHKQELEDM 202
EK L KE+E+E S +D+ + L+ E K E+E +
Sbjct: 2128 IEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 203 RKAGHE-ALSIIVDEYKALLQSSVKQQV--EAIEKQ-YISAIEKQAHKCEELLNAQHQRL 258
+ E A S+ V E + S K+ + + EKQ +S ++K + LL + Q
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
Query: 259 LEMLDTEK---ELLKEKIKE-----ALIQQSQE----QKEILEKCLEEERQRNKEALVSA 306
+++ + K E+L+ ++KE A + QE ++ L+ +EEE Q
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR 2307
Query: 307 AKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKIS 366
A+LE + K L V+++ +++ A + + E + + +QE E K
Sbjct: 2308 ARLEADEKKQ--LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 367 QETVKAAIIEEQKRSEKAVEEAVKRTRDE----LIEYIKEQKRLDQV 409
ET+KA IE +S + +E V R E E KEQ+R+ ++
Sbjct: 2366 VETLKAK-IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL 2411
Score = 49.3 bits (116), Expect = 7e-06
Identities = 63/292 (21%), Positives = 135/292 (46%), Gaps = 24/292 (8%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIK---QDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
L Q++ + KL+ +EE R+K QD E L+ K + +E KEQ + ++ E
Sbjct: 2506 LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN-LELRNLTVE 2564
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
L++K Q L+ + + L ++ YK L +++ + ++ + K K EL
Sbjct: 2565 LEQKI-QVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMS--FVEKVNKMTAKETEL 2621
Query: 251 LNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLE 310
H+ + + ++EL EK + A + ++L + ++ + + KE + ++L+
Sbjct: 2622 QREMHEMAQKTAELQEELSGEKNRLA------GELQLLLEEIKSSKDQLKELTLENSELK 2675
Query: 311 KEAVKDAVLK-VVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
K D + K VE+E K E+ + L + EK Q + +Q ++ +T
Sbjct: 2676 KSL--DCMHKDQVEKEGKVREEIAEYQLRL------HEAEKKHQALLLDTNKQYEVEIQT 2727
Query: 370 VKAAII--EEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
+ + EE S+K + +K +++EL +K ++ + +++ + +L+
Sbjct: 2728 YREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK 2779
Score = 42.7 bits (99), Expect = 7e-04
Identities = 73/370 (19%), Positives = 150/370 (40%), Gaps = 84/370 (22%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESL---MEKHNVLEKGFLKEKEQEAISFQDRYKEL 191
+++I LE +LK + E +R +Q +S + N +K F +Y++L
Sbjct: 108 KKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL 167
Query: 192 QEKHKQELEDMRKAGHEALSIIVDE-YKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+EK+ +E+E+ ++ E ++ + + L Q+++ + A + S Q K
Sbjct: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227
Query: 251 LNAQHQR--------------------------------------------LLEMLDTEK 266
L++ QR LL+ L +
Sbjct: 228 LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287
Query: 267 ELLKEKIKEALIQQSQEQKEI-------------LEKC----LEEERQRNK---EALVSA 306
+ L+ KI E ++ +KE+ LEK +E+E+ NK E + +
Sbjct: 288 QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTT 347
Query: 307 AKLEKEAVKDAVL-----KVVEE---ERKNLEKAHAEERELWKTEHAKDQEKVSQE---- 354
A+ ++ + K L K+ E+ +R+N E A + K + + QE++S++
Sbjct: 348 AQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
Query: 355 ---IQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQK-RLDQVI 410
Q+ IQ + +++QE +A + ++E +VK+ + +E K++ R +Q
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF 467
Query: 411 RQRSLSSLEL 420
+ + EL
Sbjct: 468 QASQIKENEL 477
Score = 36.6 bits (83), Expect = 0.047
Identities = 32/127 (25%), Positives = 64/127 (50%), Gaps = 10/127 (7%)
Query: 270 KEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNL 329
KE + +Q+ QE + L+K +E++QR + A L+K+ K ++ + E NL
Sbjct: 9 KEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQK---VENEKTEGTNL 65
Query: 330 EKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAV 389
++ + E+ ++ K ++K+S E+Q K SQ + + K+ + +E+ +
Sbjct: 66 KRENQRLMEICESLE-KTKQKISHELQV------KESQVNFQEGQLNSGKKQIEKLEQEL 118
Query: 390 KRTRDEL 396
KR + EL
Sbjct: 119 KRCKSEL 125
Score = 34.7 bits (78), Expect = 0.18
Identities = 65/325 (20%), Positives = 143/325 (44%), Gaps = 33/325 (10%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E SN + L+ ED V ++ + K L+ KL + E + + +E+ +E ++
Sbjct: 1778 ETSNENLRLLHVIEDRDRKVESLLNEMK--ELDSKLHLQEVQ---LMTKIEACIELEKIV 1832
Query: 170 EKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEY-KALLQSSVKQQ 228
G LK KE +S + Y + + + + + L + D+ + + +V +
Sbjct: 1833 --GELK-KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889
Query: 229 VEAIEKQYISAIEKQAHKCEELLNAQHQRL-----LEMLDTEKELLKEKIKEALIQQSQE 283
++ +++++ + + E + +H+ L LE++ TEK L ++ E
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL---------EKDNE 1940
Query: 284 QKEILEKCLEEE-----RQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERE 338
K+ + CLEEE +RN+ +K D + + ++E+ + LE +E
Sbjct: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000
Query: 339 LWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIE 398
+ A+ +EK E+ + + +S+ ++E+ +S + +A+ T+ EL
Sbjct: 2001 CIQVAEAEVKEKT--ELLQTLSSD--VSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN 2056
Query: 399 YIKEQKRLDQVIRQRSLSSLELFLS 423
I + + +++ + S SL+ LS
Sbjct: 2057 QIAQLNKEKELLVKES-ESLQARLS 2080
Score = 32.3 bits (72), Expect = 0.88
Identities = 41/183 (22%), Positives = 84/183 (45%), Gaps = 15/183 (8%)
Query: 136 QKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKH 195
QKI LE +L ++EKQ+ + ++SL E +K ++ ++ E + + + L E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSL-EAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 196 KQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQH 255
+ + +K HE + V E + Q Q+ + +KQ I +E++ +C+ L
Sbjct: 77 ESLEKTKQKISHE---LQVKESQVNFQEG---QLNSGKKQ-IEKLEQELKRCKSELERSQ 129
Query: 256 QRL------LEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNK-EALVSAAK 308
Q L +T +++ + + + +++ EK +E +R + EA V A +
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Query: 309 LEK 311
+K
Sbjct: 190 AKK 192
Score = 32.3 bits (72), Expect = 0.88
Identities = 47/235 (20%), Positives = 105/235 (44%), Gaps = 41/235 (17%)
Query: 128 NVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAIS-FQD 186
N +QL+ + + E+KL+ SE+EK+ ++ +++++ LE L++ + + IS +D
Sbjct: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI---RGDLETSNLQDMQSQEISGLKD 1263
Query: 187 RYKELQEKHKQELEDMRKAGHE------ALSIIVDEYKALLQSSVKQQVEAIE------- 233
+ +EK+ ++ + ++ +L +++ L + Q E E
Sbjct: 1264 CEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND 1323
Query: 234 --KQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALI-----QQSQEQKE 286
+ I+A K A + +LLN +++L+ + LL ++ E + +Q EQ
Sbjct: 1324 SRSECITATRKMAEEVGKLLNE-----VKILNDDSGLLHGELVEDIPGGEFGEQPNEQHP 1378
Query: 287 ILEKCLEEERQ------RNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAE 335
+ L+E +KE + A+L+++ + ++ E K L H +
Sbjct: 1379 VSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLS------LQSEHKILHDQHCQ 1427
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 69.3 bits (168), Expect = 6e-12
Identities = 72/313 (23%), Positives = 155/313 (49%), Gaps = 21/313 (6%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+L QK+++ K++ E+E + KQ E+L E+ L+ + +E+ + K+L
Sbjct: 1171 ELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT-----KIKQLL 1225
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLN 252
K K+EL D ++A + L I+ K L++S +QQVE + K ++ I + HK E L
Sbjct: 1226 VKTKKELADSKQAETDHL-ILQASLKGELEAS-QQQVE-VYKIQLAEITSEKHKIHEHLK 1282
Query: 253 A---QHQRLLEMLDTEKELLKEKIKEALIQQS------QEQKEILEKCLEEERQRN-KEA 302
QHQR L L+E+ + A +Q+ + K + L++++ ++ +A
Sbjct: 1283 TSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQA 1342
Query: 303 LVSAAKLEKEAVKDAV--LKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQ 360
AK E+E ++ + LK+ ++ +N + + E + ++EH E+ ++ +Q+ +
Sbjct: 1343 ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS 1402
Query: 361 EQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI-EYIKEQKRLDQVIRQRSLSSLE 419
++ ++ ++ +SE + +++E++ ++Q R Q ++++ +L+
Sbjct: 1403 KEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQ 1462
Query: 420 LFLSCAQKQLSAL 432
LS + QL L
Sbjct: 1463 QQLSKMEAQLFQL 1475
Score = 57.8 bits (138), Expect = 2e-08
Identities = 75/335 (22%), Positives = 153/335 (45%), Gaps = 48/335 (14%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLE----------KGFLKEKEQEAI 182
Q QK+ L +++KV E+K+ + +V+SL E++N L + FL +KE +
Sbjct: 661 QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED--V 718
Query: 183 SFQDRYKELQEKHKQELED-------MRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQ 235
++ +L++K + +E+ + + L + Y L + + ++ EK
Sbjct: 719 ILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD 778
Query: 236 YISAI----EKQAHKCEELLNAQHQRLLEMLDTEKE---LLKEKIKE-----ALIQQSQE 283
++ + E A EE N QR ++L+ EKE L +E + + +L++ ++
Sbjct: 779 VVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ 838
Query: 284 QKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTE 343
+K +L K L EE Q KEAL S + +K+A K E + L + + K+E
Sbjct: 839 EKVLLRKEL-EEIQSEKEALQS----DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE 893
Query: 344 HAKDQEKV---SQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE----EAVKRTRDEL 396
++EK E K + EQ+++ + ++++ +V+ +VK +++
Sbjct: 894 IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKI 953
Query: 397 IEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
KE K ++ ++ ++L A+K+L +
Sbjct: 954 ENLEKECKE-----KEEKINKIKLVAVKAKKELDS 983
Score = 54.3 bits (129), Expect = 2e-07
Identities = 65/319 (20%), Positives = 149/319 (46%), Gaps = 36/319 (11%)
Query: 107 LTDEKSNGTI---ALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLM 163
LT + N T+ + D+ED A + +Q K+ ++I E QR K +++
Sbjct: 1050 LTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL------EVQRAK----AMV 1099
Query: 164 EKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQS 223
+K EK ++K +E + + +ELQ + ++E + ++K E + D + L +
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
Query: 224 SVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQE 283
E + K+ + + +K E+L ++ +++ ++E L+E+I +Q S +
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDL-----EQEIKIQKQKQETLQEEITS--LQSSVQ 1212
Query: 284 QKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTE 343
Q E +++ + K+ L + + E + + +++ K +A ++ E++K +
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHL------ILQASLKGELEASQQQVEVYKIQ 1266
Query: 344 HAK---DQEKVSQEIQ-KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEY 399
A+ ++ K+ + ++ A Q QR +S + ++E+ R+ KA + V E+
Sbjct: 1267 LAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTS------EF 1320
Query: 400 IKEQKRLDQVIRQRSLSSL 418
+ R+ V++Q+ S+
Sbjct: 1321 ESYKVRVHNVLKQQKNKSM 1339
Score = 52.8 bits (125), Expect = 6e-07
Identities = 63/296 (21%), Positives = 140/296 (47%), Gaps = 26/296 (8%)
Query: 131 NIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
N +L+QK++ L L+ + +EK + Q +E LM + VL ++KE + + Y+E
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS----EDKEVLSAEVKSLYEE 693
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL 250
+L +K L + + + + ++ +K+ + +EK+ +E+Q + + L
Sbjct: 694 -----NNKLSSEKKQLSRDLEVFLSQKEDVI---LKEHITQLEKKLQLMVEEQDNLNKLL 745
Query: 251 LNAQHQRLLE-------MLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEAL 303
N Q Q+L + + E+ ++ ++ ++ Q E L K EE+ +
Sbjct: 746 ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
Query: 304 VSAAKLEKEAVKDAVLKVVE-EERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+LEKE VV+ EE K+L + + +E+ L + E + Q + + +Q + E
Sbjct: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE-KEALQSDLLEM 864
Query: 363 RKISQET---VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSL 415
+ +++T + +I+ ++ S+ + + +++ +IKE + L ++ Q+ L
Sbjct: 865 KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC--FIKEHENLKPLLEQKEL 918
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/290 (21%), Positives = 129/290 (44%), Gaps = 38/290 (13%)
Query: 117 ALVDDSEDPGANVSNI------QLQQKISSLEIKL----KVSEEEKQRIKQDVESLMEKH 166
A D+ ++ + NI Q+ I+SL+ +L + +EE + + +E+ ++H
Sbjct: 207 ATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEH 266
Query: 167 NVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKA------GHEALSIIVDEYKAL 220
+ KE + K +Q+K++ ELE++RKA ++ SI++ E
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQE-NTF 325
Query: 221 LQSSVKQQVEAIEKQYISAIEKQ----------AHKCEELLNAQHQRLLEMLDTEKELLK 270
++ V ++V+ +E + +E Q + + L Q + + E+E L+
Sbjct: 326 VEQVVNEKVKHLE-DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLE 384
Query: 271 EKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLE 330
KI E L+ + +EQ ++EK E NK+ + + +E V+ ++ +
Sbjct: 385 FKINELLLAK-EEQGCVIEKLKSELAGLNKQFCYTVEQHNRE---------VQSLKEQHQ 434
Query: 331 KAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKR 380
K +E E + ++ K++ + EIQ ++ + QE +A + E R
Sbjct: 435 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLR 484
Score = 40.4 bits (93), Expect = 0.003
Identities = 57/262 (21%), Positives = 127/262 (48%), Gaps = 25/262 (9%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+L+++I L K V+E IK E L +LEK E EQ+ +S K+
Sbjct: 50 ELEKEIEELRSK-PVTEGTGDIIKALTERLDAL--LLEKA---ETEQQCLSL----KKEN 99
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVK--QQVEAIEKQYISAIEKQAHKCEEL 250
K KQE+ED +++ + D +K L QS + +++E ++ + ++ K + L
Sbjct: 100 IKMKQEVED-------SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANL 152
Query: 251 LNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLE 310
+ + L+ ++L + E +++ QE+ E + EE+ ++ L + +
Sbjct: 153 QKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEK 212
Query: 311 KEAVKDAVLKVVEEERKNLEK---AHAEERELWKTEHAKDQEKVSQEIQKAIQE-QRKIS 366
KE V + ++E ++ +K + EE K H ++ +++ +I+ + +E + +I+
Sbjct: 213 KETVTQ-LQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEIN 271
Query: 367 Q-ETVKAAIIEEQKRSEKAVEE 387
+ +K ++++ + SEK +++
Sbjct: 272 KLNELKENLVKQCEASEKNIQK 293
Score = 33.9 bits (76), Expect = 0.30
Identities = 42/172 (24%), Positives = 76/172 (44%), Gaps = 29/172 (16%)
Query: 259 LEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV 318
LE L E + K + LIQ+++ + LEK +EE R +K E D +
Sbjct: 22 LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELR----------SKPVTEGTGDII 71
Query: 319 LKVVEE-ERKNLEKAHAEEREL-WKTEHAKDQEKVSQEIQKAIQEQRKISQE-------- 368
+ E + LEKA E++ L K E+ K +++V + K +++ Q
Sbjct: 72 KALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEI 131
Query: 369 --------TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQ 412
V++ E++ +K +EEA+ T+ EL E +K Q + +++
Sbjct: 132 ENLKNELMAVRSKYSEDKANLQKQLEEAM-NTQLELSEQLKFQNNSEDNVKK 182
Score = 30.0 bits (66), Expect = 4.4
Identities = 39/144 (27%), Positives = 64/144 (44%), Gaps = 14/144 (9%)
Query: 300 KEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQE----- 354
KE L+ AK + ++ A + E LEK E R TE D K E
Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTE-----LEKEIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 355 -IQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRL-DQVIRQ 412
++KA EQ+ +S + + +E + S + +A K I Y+KE + L ++++
Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAV 141
Query: 413 RSLSSLELFLSCAQKQLSALIATE 436
RS S + + QKQL + T+
Sbjct: 142 RSKYSED--KANLQKQLEEAMNTQ 163
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 68.9 bits (167), Expect = 8e-12
Identities = 74/326 (22%), Positives = 157/326 (48%), Gaps = 31/326 (9%)
Query: 109 DEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEE---EKQRIKQDVESLMEK 165
DE+ + + E V ++ ++K+ E K + EE E++RI++ + + E+
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 166 HNVLEKGFLKEKEQEAISFQDRYKELQEKH----KQELEDMRKAGHEALSIIVDEYKALL 221
+ + K ++QE ++ KE Q++ K++L + K + I E K
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
Query: 222 QSSVKQQVEAIEKQY-ISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIK-----E 275
Q + Q + + +Q + E Q + EE + Q Q++ + + ++ +E+ K E
Sbjct: 523 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE 582
Query: 276 ALIQQSQEQKEILEKCLEEE---RQRNKEALVSAAKLEKEAVK--DAVLKVVEEERK--- 327
+++ + +E +K EEE R++ ++ K++++ K + K+ E+E K
Sbjct: 583 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 328 NLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEE 387
EK +E ++W+ + +Q++ E +K +QEQ K+ ++ K I EQ++ EK +E
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-MQEQEKMQEQEEK---IWEQEKMEKKTQE 698
Query: 388 AVKRTRDELIEYIKEQKRLDQVIRQR 413
K+T D+ E+ R ++ +R+R
Sbjct: 699 QEKKTWDQ------EKMREEESMRER 718
Score = 63.9 bits (154), Expect = 3e-10
Identities = 57/278 (20%), Positives = 138/278 (49%), Gaps = 12/278 (4%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q+K+ E K+ E++++I+ E ++ + + ++E+E + +++ ++ ++K
Sbjct: 503 QEKMQEQEEKIW---EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
+ E M K E D+ + + + ++ E ++ + +Q K +E
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 255 HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEER-QRNKEALVSAAKL-EKE 312
++ +M + E+++ +++ E + +Q ++ E EK E++R KE L K+ E+E
Sbjct: 620 QEQEEKMWEQEEKMQEQE--EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
Query: 313 AVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKA 372
+++ K+ E+E+ +K +E++ W E +++E + + +K +E+ + ++ K
Sbjct: 678 KMQEQEEKIWEQEKME-KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 373 AIIEE--QKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
EE Q++ E+ E+ K E E + EQ+RL +
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQE--EKMWEQQRLPE 772
Score = 63.5 bits (153), Expect = 4e-10
Identities = 62/288 (21%), Positives = 141/288 (48%), Gaps = 37/288 (12%)
Query: 135 QQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVL-EKGFLKEKEQEAISFQDRYK 189
++++ E K++ EE +++R+++ + L E+ L E+ L+E+E++ +++
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 190 ELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEE 249
E +EK +++ E M + L KQ E ++Q + E++ + +E
Sbjct: 359 EQEEKMREQEEKMWRQEER------------LWEQEKQMRE--QEQKMRDQEERMWEQDE 404
Query: 250 LLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL 309
L + +R+ E +++ K + ++ + +Q ++ ++ EK EEER R +E + +
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM---RE 461
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAE---------ERELWKTEHAKDQEKVSQEIQKAIQ 360
E+E +++ K+ ++E E+ E + +LW+ E ++QE+ E ++ I+
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Query: 361 EQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+Q ++ + K E+ + E + E ++ RD+ EQK DQ
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ------EQKMWDQ 563
Score = 62.4 bits (150), Expect = 8e-10
Identities = 59/278 (21%), Positives = 136/278 (48%), Gaps = 11/278 (3%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
+Q+ E + K+ ++E++ +QD E L EK + + +EK E + K++QE+
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQD-ERLREKEERMRE---QEKMWEQVEKMREEKKMQEQ 435
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL-LNA 253
K+ + K E ++ + ++++Q E ++KQ + E++ + ++ L
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 254 QHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEA 313
Q ++L E +++ K +E I+ +E +K +E+ R +E + ++E
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE---QEEK 552
Query: 314 VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAA 373
++D K+ ++E + +K +E++ W E +E+ +E +K ++E+ ++ +E +
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
Query: 374 IIEEQK---RSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+E+K + EK E+ K E + +E+K +Q
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Score = 62.0 bits (149), Expect = 1e-09
Identities = 72/306 (23%), Positives = 149/306 (48%), Gaps = 33/306 (10%)
Query: 119 VDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQ---DVESLMEKHNVLEKGFLK 175
+ D E+ + Q+K+ E ++ EE+ + +Q D E MEK ++
Sbjct: 520 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
Query: 176 EKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQ 235
++E E + ++R +E ++K ++E E MR+ + + E + +Q ++ E EK
Sbjct: 580 DQE-EKMREEERMREREKKMREEEEMMREQEEK-----MQEQEEKMQEQEEKMWEQEEK- 632
Query: 236 YISAIEKQAHKCEELLNAQHQRLLEM--LDTEKELL--KEKIKEALIQQSQEQKEILEKC 291
+ E++ + EE + Q +++ E L +KE L EK++E Q QE+K ++
Sbjct: 633 -MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Query: 292 LEEERQRNKEALVSAAKL-EKEAVKDAVLKVVEEE----------RKNLEKAHAEERELW 340
+E++ Q ++ K+ E+E++++ K+ EEE ++ EK +E E+W
Sbjct: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW 751
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVK-RTRDELIEY 399
+QE+ E ++ + EQ+++ ++ K E+ + EK E+ K R ++E +
Sbjct: 752 ------EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
Query: 400 IKEQKR 405
+E+ R
Sbjct: 806 QEEKMR 811
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/280 (20%), Positives = 145/280 (51%), Gaps = 23/280 (8%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ 192
+L+++ L + ++ E+E+Q +Q+ + ++ + E+ +++E + Q++ Q
Sbjct: 329 ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAI-EKQYISAIEKQAHKCEELL 251
E+ ++ E+ E L E + Q + +QVE + E++ + EK+ EE +
Sbjct: 389 EQKMRDQEERMWEQDERLR--EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAK--- 308
+ + + + EK++ +E+ E + +Q ++ ++ E E+E + ++ + K
Sbjct: 447 QEEER----IREREKKMREEE--ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 309 LEKEAVKDAVLKVVEEERK--NLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKIS 366
E+E +++ K+ E+E K + E+ +E+++W+ E ++QE E ++ +++Q +
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-- 558
Query: 367 QETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRL 406
+ ++++R EK +E K+T D+ E ++E++R+
Sbjct: 559 ------KMWDQEERMEKKTQEQEKKTWDQ-EEKMREEERM 591
Score = 58.5 bits (140), Expect = 1e-08
Identities = 51/265 (19%), Positives = 123/265 (46%), Gaps = 16/265 (6%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAI------SFQDRY 188
+QK+ E +++ +E+++ D E M + + + K +E+E + Q++
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 616
Query: 189 KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCE 248
+++QE+ ++ E K + + E K Q + + + +Q E + + +
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 249 ELLNAQHQRLLEMLDTEKELLK--------EKIKEALIQQSQEQKEILEKCLEEERQRNK 300
E + Q +++ E EK+ + EK++E + +E+K E+ + E++
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 301 EALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEER--ELWKTEHAKDQEKVSQEIQKA 358
+ + ++E + + K+ E+E K E+ E+ +LW+ E ++QEK+ ++ +K
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKM 796
Query: 359 IQEQRKISQETVKAAIIEEQKRSEK 383
++ K+ + K EE+ R ++
Sbjct: 797 RDQEEKMRGQEEKMRGQEEKMRGQE 821
Score = 55.5 bits (132), Expect = 1e-07
Identities = 64/303 (21%), Positives = 146/303 (48%), Gaps = 28/303 (9%)
Query: 135 QQKISSLEIKLKVSEE---EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKEL 191
++++ + +L+ EE E++++ + VE + E+ + E+ ++E + ++R +E
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 192 QEKHKQELEDMR----KAGHEALSIIVDEYKALLQSSVKQQVEAI-EKQYISAIEKQAHK 246
++K ++E E MR K + ++ E K Q + +Q E + E++ + E++ +
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515
Query: 247 CEELLNAQHQRLLEMLDTEKELLK-EKIKEALIQQSQEQKEILEKCLEEERQRNKEALVS 305
EE + Q EM EK++ + EK++E Q ++++++ ++ E++ +E +
Sbjct: 516 QEEKIRDQE----EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ--EQKMWDQEERMEK 569
Query: 306 AAKLEKEAVKDAVLKVVEEER-KNLEKAHAEERELWKTEHAKDQEKVS-----------Q 353
+ +++ D K+ EEER + EK EE E+ + + K QE+ Q
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 354 EIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKR-TRDELIEYIKEQKRLDQVIRQ 412
E + QE++ QE E+ ++ E+ K +++ E K Q++ +++ Q
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 413 RSL 415
+
Sbjct: 690 EKM 692
Score = 50.1 bits (118), Expect = 4e-06
Identities = 66/294 (22%), Positives = 133/294 (45%), Gaps = 47/294 (15%)
Query: 133 QLQQKISSLEIKLKVSEE--EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
+LQ+ +S++ + K ++ E+ ++D SL N + LK+K E Q++
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAE---LQEKLP- 235
Query: 191 LQEKHKQELE----DMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHK 246
L E K E++ ++++ A ++ LQ + +Q E + +Q EK+ K
Sbjct: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ-----EKKIRK 290
Query: 247 CEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
EE + Q +RL E +E +++ +E+ EK L E+ + +E
Sbjct: 291 QEEKMWRQEERLRE-------------QEGKMREQEEKMWRQEKRLREQEKELREQ---- 333
Query: 307 AKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI-QEQRKI 365
EKE L+ +E R+ E+ +E ++W+ E EK+ ++ +K QE+R
Sbjct: 334 ---EKE------LREQKELREQEEQMQEQEEKMWEQE-----EKMREQEEKMWRQEERLW 379
Query: 366 SQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
QE ++ + E+ + E +R R++ +++K +QV + R ++
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ 433
Score = 46.6 bits (109), Expect = 5e-05
Identities = 48/258 (18%), Positives = 116/258 (44%), Gaps = 39/258 (15%)
Query: 132 IQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKEL 191
+Q Q+K+ E K+ E+ +++ ++ + ++ + E+ ++E+E++ ++ +E
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 192 QEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
+EK +++ E M+ +Q+ E E++ EK + E++
Sbjct: 733 EEKMQEQEEKMQ----------------------EQEEEMWEQE-----EKMWEQEEKMW 765
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEK 311
+ QRL E + E K + +E + +Q ++ ++ +EE+ R +E + + +
Sbjct: 766 --EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD------QEEKMRGQEEKMRGQEEKM 817
Query: 312 EAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVK 371
++ + E+ EK +E ++W E +++ QE + QE++ QE
Sbjct: 818 RGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK- 876
Query: 372 AAIIEEQKRSEKAVEEAV 389
+ EQ+ + EE +
Sbjct: 877 ---MREQEEKMRGQEEKI 891
Score = 46.2 bits (108), Expect = 6e-05
Identities = 55/289 (19%), Positives = 139/289 (48%), Gaps = 25/289 (8%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
+Q+ E + K+ E+E++ +Q+ + ++ + E+ +++E + Q R E +EK
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 195 --HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLN 252
+++++ K + E K Q ++++ + EK+ +++ + EE +
Sbjct: 667 LWEHEKMQEQEKMQEQ-------EEKIWEQEKMEKKTQEQEKK---TWDQEKMREEESMR 716
Query: 253 AQHQRLLE---MLDTEKELLKEKIKEALIQQSQEQKEILEKCLEE-----ERQRNKEALV 304
+ +++ E M+ ++E ++E+ +E + +Q +E E EK E+ E+QR E
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQ-EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 305 SAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRK 364
+ EK ++ + + E+ R EK +E ++ ++++ QE + QE++
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKM----RGQEEKMRGQEEKMWGQEEKM 831
Query: 365 ISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
QE E+ E+ +EE ++ +++ E ++ + ++ +R++
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 67.4 bits (163), Expect = 2e-11
Identities = 65/306 (21%), Positives = 148/306 (48%), Gaps = 47/306 (15%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
++KI LE K+ E+++I++ E E+ + E+ +E+E + +++ +E +EK
Sbjct: 390 EEKIRELEEKM----HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEEL---- 250
+++ + M + E K Q ++++ + E++ + E++ H+ EE+
Sbjct: 446 IREQEKKMWR----------QEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 251 --LNAQHQRLL----------EMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
++ Q +++ E + ++E ++E+ +E + +Q ++ +E E EEE+
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ-EEKMWRQEEKIREQEEMWREEEKMH 554
Query: 299 NKEALVSAAKLEKEAVK------------DAVLKVVEEERKNLEKAHAEERELWKTEH-A 345
+E + K +++ K + V + E+ R+ EK +E ++WK E
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 346 KDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQK---RSEKAVEEAVKRTRDELIEYIKE 402
++QE+ QE ++ I+EQ + +E + +E+K + EK E+ K E + +E
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 403 QKRLDQ 408
+K +Q
Sbjct: 675 EKIREQ 680
Score = 67.0 bits (162), Expect = 3e-11
Identities = 70/282 (24%), Positives = 146/282 (51%), Gaps = 38/282 (13%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
++K+ E K++ EE+ R ++ + EK ++E+E++ +++ +E +E
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEK--------IREQEEKMWRQEEKIREQEEM 546
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
++E E M HE I +E + + + +Q E I +Q E++ + EE + Q
Sbjct: 547 WREE-EKM----HEQEKIWEEEKRQEQEDKMWRQEEKIREQ-----EEKVWRQEEKIREQ 596
Query: 255 HQRLLEMLDTEKELLK--EKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKE 312
++ E E+++ K EKI+E ++ QEQ+E + + +EE+ R +E + ++E
Sbjct: 597 EEKRQEQ---EEKMWKQEEKIREQE-EKIQEQEEKIRE--QEEKIREQEEMTQE---QEE 647
Query: 313 AVKDAVLKVVEEERKNLEKAHAEERELWKTEHA-KDQEKVSQEIQKAIQEQRKISQETVK 371
+ + K+ E+E EK +E +W+ E ++QEK +E ++ I+EQ ++ QE +
Sbjct: 648 KMGEQEEKMCEQE----EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 703
Query: 372 AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
+E+K E+ EE ++ +++ +E+K +Q +R R
Sbjct: 704 KMWEQEEKMCEQ--EEKMQEQEEKMRR--QEEKMWEQEVRLR 741
Score = 60.5 bits (145), Expect = 3e-09
Identities = 66/292 (22%), Positives = 141/292 (48%), Gaps = 24/292 (8%)
Query: 129 VSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRY 188
+++ +L++K + L+ KL++ E EK I+ +V+ L K LE+ L +Q+ + D
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK---LERAKLLLPQQQLQAEADHL 270
Query: 189 -KELQE-KHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHK 246
KELQ K + + L+ +E + +++ E I++Q E++ +
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ-----EEKIRE 325
Query: 247 CEELLNAQHQRLL--EMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALV 304
EE + Q +++ E + EKE + +E + ++ ++ + E E+E + ++ +
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 385
Query: 305 SAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRK 364
K EK ++ +EE+ EK +E + + E ++QEK ++ K +++ K
Sbjct: 386 MWEKEEK-------IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 438
Query: 365 ISQETVKAAIIEEQK---RSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQR 413
I ++ K I E++K R E+ + E K +E + +E R ++ I ++
Sbjct: 439 IREQEEK--IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ 488
Score = 58.5 bits (140), Expect = 1e-08
Identities = 65/283 (22%), Positives = 140/283 (49%), Gaps = 23/283 (8%)
Query: 133 QLQQKISSLEIKLKVSEE--EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
+L+Q +S++ + K ++ E+ ++D SL N + LKEK + Q++ +
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAK---LQEKL-Q 231
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALL-QSSVKQQVEAIEKQYISAIEKQAHKCEE 249
L E K E++ + L ++ K LL Q ++ + + + K+ S K + EE
Sbjct: 232 LVESEKSEIQ----LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEE 287
Query: 250 --LLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA 307
L N +Q+ E + ++E ++E +E + +Q ++ +E EK E+E + ++ +
Sbjct: 288 NELWNRLNQQQEEKMWRQEEKIQEW-EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346
Query: 308 KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK--DQEKVSQEIQKAIQEQRKI 365
K EK ++ ++ EE+ + E+ E+ E + + ++E+ +E+++ + EQ KI
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 406
Query: 366 SQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
++ EE+++ E+ + E KR E + +E+K +Q
Sbjct: 407 REQ-------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Score = 57.4 bits (137), Expect = 3e-08
Identities = 76/315 (24%), Positives = 143/315 (45%), Gaps = 46/315 (14%)
Query: 119 VDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKE 178
+ + E+ I+ Q+K E K+ EE +I++ E + E+ + + K E
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---KIREQEEKIREQEKKMWRQEEKIHE 462
Query: 179 QEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAI--EKQ 235
QE I +++ +E +E +QE + HE I + K Q +++Q E + +++
Sbjct: 463 QEKIREEEKRQEQEEMWRQE-----EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517
Query: 236 YISAIEKQAHKCEELLNAQHQRLLEM----LDTEKELLKEKIKEALIQQSQEQK------ 285
I E++ + EE + Q +++ E + EK +EKI E +Q QE K
Sbjct: 518 KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577
Query: 286 ----------EILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAE 335
EK E+E +R + ++E + K+ E+E K E+ E
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQE---------QEEKMWKQEEKIREQEEKIQEQ---E 625
Query: 336 ERELWKTEHAKDQEKVSQEIQKAI--QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTR 393
E+ + E ++QE+++QE ++ + QE++ QE E R E+ + E K+ R
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR 685
Query: 394 DELIEYIKEQKRLDQ 408
++ E I+EQ+ + Q
Sbjct: 686 EQ-EEKIREQEEMMQ 699
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/217 (23%), Positives = 106/217 (48%), Gaps = 33/217 (15%)
Query: 146 KVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDM--- 202
K+ EEEK++ ++D E+ ++E+E++ +++ +E +EK +++ E M
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEK-------IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 203 -RKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLE 260
K + I E K Q +++Q E ++Q E++ CE+ Q Q E
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE--E 668
Query: 261 MLDTEKELLKEKIKEALIQQSQ--EQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV 318
+ ++E ++E+ K+ Q+ + EQ+E++++ +EE+ +E E + +
Sbjct: 669 TMWRQEEKIREQEKKIREQEEKIREQEEMMQE--QEEKMWEQE----------EKMCEQE 716
Query: 319 LKVVEEERKNLEKAHAEERELWKTE-HAKDQEKVSQE 354
K+ E+E EK +E ++W+ E + QE+ QE
Sbjct: 717 EKMQEQE----EKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 67.0 bits (162), Expect = 3e-11
Identities = 88/360 (24%), Positives = 172/360 (47%), Gaps = 39/360 (10%)
Query: 105 LGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQR---IKQD--V 159
L + N T + D S + +L++++ + E++LK E+K R IK D +
Sbjct: 406 LSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHN-EMQLKDEMEQKCRTSNIKLDKIM 464
Query: 160 ESLMEKHNVLE--KGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEY 217
+ L E+ N + + + E+E + Q R E Q K +QE E R +E +S + D+
Sbjct: 465 KELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENE-VSTLKDQL 523
Query: 218 KALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIK-EA 276
+ L + S Q + + +S ++KQ + +LL + + + + E+ K + E+
Sbjct: 524 EDLKKVSQNSQ---LANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLES 580
Query: 277 LIQQSQEQKEILE--KCLEEERQRNKEALVSAAKLEK----EAVKDAVLKV--VEEERK- 327
L ++ QE+ ILE K ++ +A++ A + ++ E + D ++ ++EE K
Sbjct: 581 LNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKH 640
Query: 328 ---NLEKAHAEERELWKTEHAKDQEKVSQEIQ-----KAIQ---EQRKISQETVKAAIIE 376
NLEK E +E + ++EK + EI K++Q EQ + KA + +
Sbjct: 641 LKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTD 700
Query: 377 EQKRSEKAVEEAV----KRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSAL 432
+ + E+A A+ K+ ++E K + R+ Q+ +Q S+ L++ L +Q++L L
Sbjct: 701 KHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSM--LDVDLKQSQQKLEHL 758
Score = 56.2 bits (134), Expect = 6e-08
Identities = 82/368 (22%), Positives = 161/368 (43%), Gaps = 91/368 (24%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQE 193
LQ +I+SL+ ++K + ++++ + + + N EK EK I + K LQ+
Sbjct: 627 LQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEK----EKNNLEIDLNYKLKSLQQ 682
Query: 194 KHKQE----------LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEK--QYISAIE 241
+ +QE L D ++ EA S+ + E ++ +K++ EA EK + IE
Sbjct: 683 RLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE----MEKKLKEEREAREKAENRVVQIE 738
Query: 242 KQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILE------------ 289
KQ + L Q Q+ LE L KE +++++K +Q QE + L
Sbjct: 739 KQCSMLDVDLK-QSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEA 797
Query: 290 ---KCLEEERQRNKEALVSAAKL-----------------------------------EK 311
K LE++ ++ L+ A +L K
Sbjct: 798 DNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYK 857
Query: 312 EAVKDAVLKVVEEERKNLEKAH--AEERELWKTEHAKDQEKV-SQEIQKAIQEQR--KIS 366
VK+ ++ E+ R+NL+K E+E T+ + K S+++ + + E++ +++
Sbjct: 858 TQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELT 917
Query: 367 QETVKAAIIEEQKRSEK-----AVEEA----------VKRTRDELIEYIKEQKRLDQVIR 411
QE+ KAA Q+ ++K +EEA ++R +EL E +K+ + ++ +
Sbjct: 918 QESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEK 977
Query: 412 QRSLSSLE 419
+ +S+L+
Sbjct: 978 EEEISNLK 985
Score = 48.9 bits (115), Expect = 9e-06
Identities = 70/310 (22%), Positives = 136/310 (43%), Gaps = 65/310 (20%)
Query: 107 LTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKH 166
+ DE N T+ L +S + LQ ++ + + + ++++KQ++ +L+E
Sbjct: 765 MEDEVKNLTLQLEQESN------KRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAK 818
Query: 167 NVLE-------------KGFLKEKEQEAIS---FQDRYK--------ELQEKHKQELEDM 202
+LE +G ++E + + + F YK E++EK+++ L+ +
Sbjct: 819 RLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKI 878
Query: 203 RKAGHE--------------------ALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEK 242
++ +E A ++ ++Y L Q S K + +Q I+ +
Sbjct: 879 QELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKK--AASRNRQEITDKDH 936
Query: 243 QAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEA 302
+ EE N+ + +E+L E E L EK+K+A E++ LEK EEE K A
Sbjct: 937 TVSRLEEA-NSMLTKDIEILRRENEELTEKMKKA------EEEYKLEK--EEEISNLKAA 987
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI-QE 361
E+ AV K+ E + K +R+ T+ + +EK ++++Q + QE
Sbjct: 988 FEKNINTERTLKTQAVNKLAEIMNR---KDFKIDRKKANTQDLRKKEKENRKLQLELNQE 1044
Query: 362 QRKISQETVK 371
+ K +Q VK
Sbjct: 1045 REKFNQMVVK 1054
Score = 31.6 bits (70), Expect = 1.5
Identities = 30/188 (15%), Positives = 84/188 (44%), Gaps = 14/188 (7%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN--VLEKGFLKEKEQEAISFQDRYKELQ 192
+ K S ++ + EE+ + Q+ + ++ + +K + +EA S + E+
Sbjct: 896 ETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEIL 955
Query: 193 EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQV---EAIEKQYISAIEKQAHKCEE 249
+ +EL + K E + +E + L+++ ++ + ++ Q ++ + + ++ +
Sbjct: 956 RRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDF 1015
Query: 250 LLNAQHQRLLEMLDTEKELLK---------EKIKEALIQQSQEQKEILEKCLEEERQRNK 300
++ + ++ EKE K EK + +++ +E ++ + +EE RN+
Sbjct: 1016 KIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNE 1075
Query: 301 EALVSAAK 308
+ A+K
Sbjct: 1076 LQMQLASK 1083
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 67.0 bits (162), Expect = 3e-11
Identities = 74/296 (25%), Positives = 146/296 (49%), Gaps = 30/296 (10%)
Query: 130 SNIQLQQKISSLEIKLKVSEEE----KQRIKQDVESLME-----------KHNVLEKGFL 174
S ++ ++ +LEI L+ +EE + ++K+ E+ +E +H E
Sbjct: 688 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
Query: 175 KEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEK 234
K++ +A + DR E+ ++ + E D K E + D+ K + K+QVE K
Sbjct: 748 KDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE---K 804
Query: 235 QYISAIEKQAHKCEELLNAQHQRLLEML---DTEKELLKEKIKEALIQQSQEQKEILEKC 291
+ + + ++A + E+ LN Q+L + L D E L+E ++E+ +Q + E++ +L +
Sbjct: 805 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES-VQITAEREMVLAQ- 862
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKV 351
EE + N E V + E VK L+ ++ + + +++ AE +E T ++ K
Sbjct: 863 -EESARTNAEKQVEELLMAMEKVKQE-LESMKAKLSSTQQSLAE-KETHLTNLRAERRKH 919
Query: 352 SQEIQKAIQEQ--RKISQETVKAAIIEEQKRSEKAVEE--AVKRTRDELIEYIKEQ 403
+E+ + QE IS++ A++E +K EE A+KR +D L++ +K+Q
Sbjct: 920 LEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
Score = 48.5 bits (114), Expect = 1e-05
Identities = 58/289 (20%), Positives = 139/289 (48%), Gaps = 34/289 (11%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQE 193
++ K+ L+ +L E + + +K+ L + +++ L K+ E ++ Q + + L
Sbjct: 436 MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE-LSRKDTELLALQTKLETLTN 494
Query: 194 KH---KQELEDMRKA-------------GHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
+ KQ +E ++++ +AL + ++E + +L KQ + E++
Sbjct: 495 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ 297
A E H +++L+ + +R + +L + E L+E++++ Q S ++ + K L+ +
Sbjct: 555 QAGE--IHDLKDMLDVK-ERKVNVLQKKIENLQEQLRDKEKQMSSLKERV--KSLQADTT 609
Query: 298 RNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQK 357
AL + E A K+ ++ ++E+R E+ EE + +K + +EKVS +Q
Sbjct: 610 NTDTALTTLE--EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL-LQG 666
Query: 358 AIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKR-TRDELIEYIKEQKR 405
+ E+ +A++++ ++ + +K+ +R + +E EQK+
Sbjct: 667 DLSEK--------EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKK 707
Score = 42.0 bits (97), Expect = 0.001
Identities = 75/358 (20%), Positives = 159/358 (44%), Gaps = 62/358 (17%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQD----RY 188
+L + + S + K +EE+ +R ++ E+ M H++ + L++KE+E ++ R+
Sbjct: 311 KLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHL--ESLLEQKEKENSMLREEMHRRF 368
Query: 189 KELQEKHKQ-------ELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQ------ 235
+ + K E++D + + E ++E +L+S+ E E++
Sbjct: 369 ENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
Query: 236 YISAIEKQAHKCEEL------LNAQHQRL-----------------LEMLDTEKELLKEK 272
Y S + +K E+L AQ + L L DTE L+ K
Sbjct: 429 YRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTK 488
Query: 273 IKEALIQQSQEQK---EILEKCL--EEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERK 327
+ E L Q + K E+L++ L +E+R + V A +L E + + K ++ +
Sbjct: 489 L-ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQD 547
Query: 328 NLEKAHAEERELWKTEHAKD-QEKVSQEIQKAIQE-QRKISQETVKAAIIEEQKRSEKA- 384
E+ + E+ + D +E+ +QK I+ Q ++ + + + ++E+ +S +A
Sbjct: 548 MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD 607
Query: 385 ----------VEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSAL 432
+EEA+ ++ IE +KEQ+ D+ +Q + + + L ++++S L
Sbjct: 608 TTNTDTALTTLEEALAE-KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLL 664
Score = 38.1 bits (87), Expect = 0.016
Identities = 65/322 (20%), Positives = 138/322 (42%), Gaps = 31/322 (9%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQE 193
L++ + +E+++ E +KQ + ES+ + +L+ L K E + R E
Sbjct: 284 LRKTLEEMELRI---ETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAE 340
Query: 194 KHKQELEDMRKAGHEALSIIVDEYKALLQSS-------VKQQVEAIEKQYISAIEKQAHK 246
H LE + + + S++ +E +++ Q V ++ IS++E+
Sbjct: 341 MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
Query: 247 CEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSA 306
EE Q + L TE+ + K E S+ K +E+ EE +KEA
Sbjct: 401 LEE--EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEE--LSSKEAQWEE 456
Query: 307 AKLEKEAVKDAVLKVVEE-ERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI--QEQR 363
K + ++ + +V +E RK+ E + + T D ++ + +++++ +EQR
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 364 KISQETVKAAIIEEQKRSEKAVEEAVKRTRD-------------ELIEYIKEQKRLDQVI 410
+T A+ + E + + K+ +D +L + + ++R V+
Sbjct: 517 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL 576
Query: 411 RQRSLSSLELFLSCAQKQLSAL 432
Q+ + +L+ L +KQ+S+L
Sbjct: 577 -QKKIENLQEQLRDKEKQMSSL 597
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 67.0 bits (162), Expect = 3e-11
Identities = 74/296 (25%), Positives = 146/296 (49%), Gaps = 30/296 (10%)
Query: 130 SNIQLQQKISSLEIKLKVSEEE----KQRIKQDVESLME-----------KHNVLEKGFL 174
S ++ ++ +LEI L+ +EE + ++K+ E+ +E +H E
Sbjct: 660 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 719
Query: 175 KEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEK 234
K++ +A + DR E+ ++ + E D K E + D+ K + K+QVE K
Sbjct: 720 KDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE---K 776
Query: 235 QYISAIEKQAHKCEELLNAQHQRLLEML---DTEKELLKEKIKEALIQQSQEQKEILEKC 291
+ + + ++A + E+ LN Q+L + L D E L+E ++E+ +Q + E++ +L +
Sbjct: 777 KKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES-VQITAEREMVLAQ- 834
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKV 351
EE + N E V + E VK L+ ++ + + +++ AE +E T ++ K
Sbjct: 835 -EESARTNAEKQVEELLMAMEKVKQE-LESMKAKLSSTQQSLAE-KETHLTNLRAERRKH 891
Query: 352 SQEIQKAIQEQ--RKISQETVKAAIIEEQKRSEKAVEE--AVKRTRDELIEYIKEQ 403
+E+ + QE IS++ A++E +K EE A+KR +D L++ +K+Q
Sbjct: 892 LEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 947
Score = 48.5 bits (114), Expect = 1e-05
Identities = 69/330 (20%), Positives = 152/330 (46%), Gaps = 34/330 (10%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQD----RY 188
+L + + S + K +EE+ +R ++ E+ M H++ + L++KE+E ++ R+
Sbjct: 311 KLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHL--ESLLEQKEKENSMLREEMHRRF 368
Query: 189 KELQEKHKQ-------ELEDMRKAGHE-ALSIIVDEYKALLQSSVKQQVEAIEKQYISAI 240
+ + K E++D + + E L + +E + L + E E+ +
Sbjct: 369 ENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
Query: 241 EKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK---EILEKCL--EEE 295
+ K + Q ++ L DTE L+ K+ E L Q + K E+L++ L +E+
Sbjct: 429 YRSHSKFMKNKIGQVKQELSRKDTELLALQTKL-ETLTNQFSDSKQHIEVLKESLTAKEQ 487
Query: 296 RQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKD-QEKVSQE 354
R + V A +L E + + K ++ + E+ + E+ + D +E+
Sbjct: 488 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 547
Query: 355 IQKAIQE-QRKISQETVKAAIIEEQKRSEKA-----------VEEAVKRTRDELIEYIKE 402
+QK I+ Q ++ + + + ++E+ +S +A +EEA+ ++ IE +KE
Sbjct: 548 LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAE-KERTIERLKE 606
Query: 403 QKRLDQVIRQRSLSSLELFLSCAQKQLSAL 432
Q+ D+ +Q + + + L ++++S L
Sbjct: 607 QRDRDEREKQEEIDNYKKDLKDLKEKVSLL 636
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 67.0 bits (162), Expect = 3e-11
Identities = 72/292 (24%), Positives = 149/292 (51%), Gaps = 35/292 (11%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEK-GFLKEKEQ----EAISFQDRY 188
LQ+++ E +L+ E+EK+ KQ+ + ++ + E+ G ++E+E+ + +++
Sbjct: 232 LQEEMWRQEEELR--EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289
Query: 189 KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAI--EKQYISAIEKQAH 245
KEL+E+ K EL + +K + + E K Q +++Q E + +++ + EKQ
Sbjct: 290 KELREQEK-ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 246 KCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVS 305
+ E+ + Q +R+ E + E L+EK E +++ ++ E EK EEER R +E +
Sbjct: 349 EQEQKMRDQEERMWE----QDERLREK--EERMREQEKMWEQEEKMQEEERIREREKKM- 401
Query: 306 AAKLEKEAVKDAVLKVVEEERKNLEKAHAE---------ERELWKTEHAKDQEKVSQEIQ 356
+ E+E +++ K+ ++E E+ E + +LW+ E ++QE+ E +
Sbjct: 402 --REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 459
Query: 357 KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQ 408
+ I++Q ++ + K E+ + E + E ++ RD+ EQK DQ
Sbjct: 460 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ------EQKMWDQ 505
Score = 64.3 bits (155), Expect = 2e-10
Identities = 60/306 (19%), Positives = 152/306 (49%), Gaps = 36/306 (11%)
Query: 135 QQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVL-EKGFLKEKEQEAISFQDRYK 189
++++ E K++ EE +++R+++ + L E+ L E+ L+E+E++ +++
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 190 ELQEKHKQELEDM----------RKAGHEALSIIVDEYKALLQSS--VKQQVEAIEKQYI 237
E +EK +++ E M K E + D+ + + + ++++ E + +Q
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 380
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ 297
+++ + EE + + +++ E +T +E ++ K+ QE+KE ++ L E+++
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 298 RNKEALVSAAKLEKEAVKDAVLKVVEEERK--NLEKAHAEERELWKTEHAKDQ------- 348
+ E+E +++ K+ E+E K + E+ +E+++W+ E ++Q
Sbjct: 441 K---------LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 491
Query: 349 -EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLD 407
EK+ + QK ++ ++ ++ + EE+ R +K + + ++ R+E +E+K D
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 408 QVIRQR 413
Q + R
Sbjct: 552 QEEKMR 557
Score = 59.3 bits (142), Expect = 7e-09
Identities = 55/256 (21%), Positives = 123/256 (48%), Gaps = 25/256 (9%)
Query: 150 EEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEA 209
E+ +R+++ E + E+ + E+ +EK QE ++R K+++E+ + E K +
Sbjct: 363 EQDERLREKEERMREQEKMWEQ---EEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 210 LSIIVDEYKALLQSSVKQQVEAI-EKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ E K Q + +Q E + E++ + E++ + EE + Q EM EK++
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE----EMWGQEKKM 475
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKN 328
++ E + +Q + E +EE+ R++E +K ++ + +E +
Sbjct: 476 WRQ---EKMREQEDQMWE------QEEKMRDQE--------QKMWDQEERMWEQDERLRE 518
Query: 329 LEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEA 388
E+ E++++W+ E +EK +QE +K +Q + +E + E++ R E+ +
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 578
Query: 389 VKRTRDELIEYIKEQK 404
+ E E ++EQ+
Sbjct: 579 QEEKMQEQEEKMREQE 594
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/235 (20%), Positives = 117/235 (49%), Gaps = 21/235 (8%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q+K+ E K++ EEK+ +Q+ ++ ++ + E+ ++E+E++ ++ +E +EK
Sbjct: 526 QKKMWQQEEKMR---EEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
+++ E MR+ + E + +Q ++ E EK + E + + EE++ Q
Sbjct: 583 MQEQEEKMREQEEKMW-----EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQ 637
Query: 255 HQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLE-EERQRNKEALVSAAKLEKEA 313
+++ E +E + +Q ++ +E EK E EE+ + +E + + + +
Sbjct: 638 EEKMQEQ------------EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 314 VKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQE 368
++ + + E+ R EK +E ++W E ++ +E ++ I++Q++ QE
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 55.5 bits (132), Expect = 1e-07
Identities = 71/312 (22%), Positives = 148/312 (47%), Gaps = 44/312 (14%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKE-----QEAISFQDR 187
+L++K + + K+ E+E++ +++ EK E+ ++E+E QE ++
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 426
Query: 188 YKELQE----KHKQELEDMRKAGHEALSI------IVD-------EYKALLQSSVKQQVE 230
KE Q+ + K++L + K + I I D E K Q +++Q +
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 231 AI--EKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLK-----EKIKEALIQQSQE 283
+ +++ + E++ EE + Q +RL E + +E K EK++E Q QE
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546
Query: 284 QK--EILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWK 341
+K + EK EEER R +E + E+E +++ K+ E+E EK +E ++W
Sbjct: 547 KKTWDQEEKMREEERMRERE---KKMREEEEMMREQEEKMQEQE----EKMREQEEKMW- 598
Query: 342 TEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIK 401
+QE+ QE ++ + EQ + E + ++EQ+ EE ++ +++ E +
Sbjct: 599 -----EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEE 653
Query: 402 EQKRLDQVIRQR 413
+ + ++ +R++
Sbjct: 654 KMREQEEKMREQ 665
Score = 53.5 bits (127), Expect = 4e-07
Identities = 56/260 (21%), Positives = 124/260 (47%), Gaps = 28/260 (10%)
Query: 135 QQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
++KI E K++ EE EK+ +Q+ E ++ ++++EQ+ ++R E
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWE 511
Query: 191 LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKC--E 248
E+ +++ E MR E K + Q K + E ++ Q K E
Sbjct: 512 QDERLREKEERMR------------EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559
Query: 249 ELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAK 308
E + + +++ E E+E+++E+ +E + +Q ++ +E EK E+E + ++ +
Sbjct: 560 ERMREREKKMRE----EEEMMREQ-EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Query: 309 LEKEAVKDAVLKVVEEER---KNLEKAHAEERELWKTEH--AKDQEKVSQEIQKAIQEQR 363
EK ++ K+ E+E + EK +E ++W+ E + +EK+ ++ +K ++
Sbjct: 615 EEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE 674
Query: 364 KISQETVKAAIIEEQKRSEK 383
K+ ++ K EE+ R ++
Sbjct: 675 KMREQEEKMQGQEEKMREQE 694
Score = 52.8 bits (125), Expect = 6e-07
Identities = 65/321 (20%), Positives = 147/321 (45%), Gaps = 55/321 (17%)
Query: 132 IQLQQKISSLEIKLKVSEE----EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR 187
+Q +++I E K++ EE +++++++ E++ E+ + +++E + Q++
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 447
Query: 188 YKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAI--EKQYISAIEKQAH 245
+E +EK ++ E +R + + E K Q +++Q + + +++ + E++
Sbjct: 448 MQEQEEKIWEQEEKIR----DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 246 KCEELLNAQHQRLLEMLDTEKELLK-----EKIKEALIQQSQEQK--EILEKCLEEERQR 298
EE + Q +RL E + +E K EK++E Q QE+K + EK EEER R
Sbjct: 504 DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 299 NKEALVSAAKLEKEAVKDAVLKVVEEERK----------NLEKAHAEERELWKTEHA--- 345
+E + + E+E +++ K+ E+E K EK +E ++W+ E
Sbjct: 564 EREKKM---REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Query: 346 ----------------------KDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEK 383
+ +EK+ ++ +K +++ K+ ++ K EE+ R ++
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE 680
Query: 384 AVEEAVKRTRDELIEYIKEQK 404
+ + E E ++ Q+
Sbjct: 681 EKMQGQEEKMREQEEKMRGQE 701
Score = 43.9 bits (102), Expect = 3e-04
Identities = 56/237 (23%), Positives = 110/237 (46%), Gaps = 41/237 (17%)
Query: 177 KEQEAISFQ-----DRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEA 231
KE++A+S + +EL++K+ + E +R A E K+ +Q +VK+
Sbjct: 166 KERDALSLELYRNTITNEELKKKNAELQEKLRLAESE---------KSEIQLNVKELKRK 216
Query: 232 IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKC 291
+E+ + Q + +E + Q + L E EK++ K QE+K
Sbjct: 217 LERAKFLLPQVQTNTLQEEMWRQEEELREQ---EKKIRK-----------QEEK----MW 258
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKV 351
+EER R +E + E+E K + E+ K L + +E+EL + + ++QE+
Sbjct: 259 RQEERLREQEGKMR----EQEEKMRRQEKRLREQEKELRE---QEKELREQKKLREQEEQ 311
Query: 352 SQEIQKAIQEQRKISQETVKAAIIEEQK--RSEKAVEEAVKRTRDELIEYIKEQKRL 406
QE ++ + EQ + +E + +E++ EK + E ++ RD+ ++ +RL
Sbjct: 312 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 368
Score = 34.3 bits (77), Expect = 0.23
Identities = 47/254 (18%), Positives = 114/254 (44%), Gaps = 15/254 (5%)
Query: 121 DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE 180
D E+ ++ ++K E ++ +EEK + +++ E+ ++ ++E+E++
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 181 AISFQDRYKELQEKHK-QELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQ--YI 237
+++ E +E+ K QE E+M E + +E + +++Q E + +Q +
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ-EQEEKMWEQEEKMREQEEKMREQEEKM 669
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQ 297
E++ + EE + Q +++ E ++E ++ + +E + Q ++ EK +E
Sbjct: 670 QGQEEKMREQEEKMQGQEEKMRE----QEEKMRGQ-EEKMWGQEEKMWGQEEKMWGQEEM 724
Query: 298 RNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQK 357
R KE + + +KE +++ ++ E E + E + L H E E +
Sbjct: 725 REKEERI---RDQKEKMQE---RLPEHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEAGE 778
Query: 358 AIQEQRKISQETVK 371
+ +QE ++
Sbjct: 779 GSPQDNPTAQEIMQ 792
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
1 [Homo sapiens]
Length = 1722
Score = 66.2 bits (160), Expect = 6e-11
Identities = 70/282 (24%), Positives = 135/282 (47%), Gaps = 44/282 (15%)
Query: 150 EEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEA 209
E +++ +Q E+ EK LE +KE++ + Q ++ +EK QE E+ R +
Sbjct: 162 EVEEKCRQSFEAWQEKQKELE-----DKEKQTLKAQ---RDREEKQFQEEEEKRHCWMKQ 213
Query: 210 LSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNA---QHQRLLEMLDTEK 266
+ K+++E I+KQ + + +K E++ QH+ + L +
Sbjct: 214 FKV------------EKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQM 261
Query: 267 ELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEER 326
E + + K+ QQ +E+ +L +Q+N A+ AK + +++E+
Sbjct: 262 EEERTRFKD---QQEKEKNSLL-------KQQNNAAVKIQAKYKAFVAYQKYGPIIKEQI 311
Query: 327 KNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE 386
++ +K A+E WK + AK ++K +E +K ++E+++I +E K EE+KR EK E
Sbjct: 312 ES-KKRKAQE---WKEKEAKIRQK-EEENRKRLEEEQRIKEERKKQKE-EERKRREKEYE 365
Query: 387 EAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
E + E + I ++K I R +S +L +S A K+
Sbjct: 366 EKKNIVKQEREQLISKEK-----IILREDASQQLIISSALKK 402
Score = 54.3 bits (129), Expect = 2e-07
Identities = 71/299 (23%), Positives = 141/299 (47%), Gaps = 34/299 (11%)
Query: 135 QQKISSLEIKLK--VSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR----- 187
Q+K LE K K + + + KQ E ++H +++ +++K+ E I Q++
Sbjct: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Query: 188 --YKE---LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEK 242
YKE +EK KQ E +R L + ++E + + +++ ++ KQ +A K
Sbjct: 235 ELYKEEKIWKEKFKQHEEYIRN-----LHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVK 289
Query: 243 QAHKCEELLNAQHQR--LLEMLDTEKELLKE-KIKEALIQQSQEQKEIL---EKCLEEER 296
K + + Q + E ++++K +E K KEA I+Q +E+ E+ ++EER
Sbjct: 290 IQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
++ KE + E E K+ +V++ER+ L + ++ E A Q +S ++
Sbjct: 350 KKQKEEERKRREKEYEEKKN----IVKQEREQL----ISKEKIILREDASQQLIISSALK 401
Query: 357 KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSL 415
K+ + +S E + ++ ++ V+E K+ D L+ ++E + V RQ L
Sbjct: 402 KSGYNNKHLSLEDISN---DKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTIL 457
Score = 45.8 bits (107), Expect = 8e-05
Identities = 65/293 (22%), Positives = 127/293 (43%), Gaps = 34/293 (11%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
+QK + + K EE+K +KQ+ E L+ K EK L+E + + K+
Sbjct: 351 KQKEEERKRREKEYEEKKNIVKQEREQLISK----EKIILREDASQQLIISSALKKSGYN 406
Query: 195 HKQ-ELEDMRKAGHEALSIIVDEYKA---------LLQSSVKQQVE--AIEKQYISAIEK 242
+K LED+ + +VDE + +S++K+ V+ I K+ I K
Sbjct: 407 NKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLK 466
Query: 243 QAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCL--------EE 294
++ + +L +M + + L K++ E L++Q ++ + K
Sbjct: 467 ESISSQTILAD-----FKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNL 521
Query: 295 ERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK----DQEK 350
+ Q + L S A+ E++ +K + + ++ + + + E E+ E K +Q+K
Sbjct: 522 KEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQK 581
Query: 351 VSQEIQKA-IQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKE 402
Q+++K IQEQ + + +I ++RS E K R+ +I KE
Sbjct: 582 KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKE 634
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform
2 [Homo sapiens]
Length = 1336
Score = 66.2 bits (160), Expect = 6e-11
Identities = 70/282 (24%), Positives = 135/282 (47%), Gaps = 44/282 (15%)
Query: 150 EEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEA 209
E +++ +Q E+ EK LE +KE++ + Q ++ +EK QE E+ R +
Sbjct: 162 EVEEKCRQSFEAWQEKQKELE-----DKEKQTLKAQ---RDREEKQFQEEEEKRHCWMKQ 213
Query: 210 LSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNA---QHQRLLEMLDTEK 266
+ K+++E I+KQ + + +K E++ QH+ + L +
Sbjct: 214 FKV------------EKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQM 261
Query: 267 ELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEER 326
E + + K+ QQ +E+ +L +Q+N A+ AK + +++E+
Sbjct: 262 EEERTRFKD---QQEKEKNSLL-------KQQNNAAVKIQAKYKAFVAYQKYGPIIKEQI 311
Query: 327 KNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE 386
++ +K A+E WK + AK ++K +E +K ++E+++I +E K EE+KR EK E
Sbjct: 312 ES-KKRKAQE---WKEKEAKIRQK-EEENRKRLEEEQRIKEERKKQKE-EERKRREKEYE 365
Query: 387 EAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
E + E + I ++K I R +S +L +S A K+
Sbjct: 366 EKKNIVKQEREQLISKEK-----IILREDASQQLIISSALKK 402
Score = 54.3 bits (129), Expect = 2e-07
Identities = 71/299 (23%), Positives = 141/299 (47%), Gaps = 34/299 (11%)
Query: 135 QQKISSLEIKLK--VSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDR----- 187
Q+K LE K K + + + KQ E ++H +++ +++K+ E I Q++
Sbjct: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEKKKLENIQKQEQDKMND 234
Query: 188 --YKE---LQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEK 242
YKE +EK KQ E +R L + ++E + + +++ ++ KQ +A K
Sbjct: 235 ELYKEEKIWKEKFKQHEEYIRN-----LHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVK 289
Query: 243 QAHKCEELLNAQHQR--LLEMLDTEKELLKE-KIKEALIQQSQEQKEIL---EKCLEEER 296
K + + Q + E ++++K +E K KEA I+Q +E+ E+ ++EER
Sbjct: 290 IQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEER 349
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
++ KE + E E K+ +V++ER+ L + ++ E A Q +S ++
Sbjct: 350 KKQKEEERKRREKEYEEKKN----IVKQEREQL----ISKEKIILREDASQQLIISSALK 401
Query: 357 KAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSL 415
K+ + +S E + ++ ++ V+E K+ D L+ ++E + V RQ L
Sbjct: 402 KSGYNNKHLSLEDISN---DKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTIL 457
Score = 45.8 bits (107), Expect = 8e-05
Identities = 65/293 (22%), Positives = 127/293 (43%), Gaps = 34/293 (11%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
+QK + + K EE+K +KQ+ E L+ K EK L+E + + K+
Sbjct: 351 KQKEEERKRREKEYEEKKNIVKQEREQLISK----EKIILREDASQQLIISSALKKSGYN 406
Query: 195 HKQ-ELEDMRKAGHEALSIIVDEYKA---------LLQSSVKQQVE--AIEKQYISAIEK 242
+K LED+ + +VDE + +S++K+ V+ I K+ I K
Sbjct: 407 NKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLK 466
Query: 243 QAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCL--------EE 294
++ + +L +M + + L K++ E L++Q ++ + K
Sbjct: 467 ESISSQTILAD-----FKMEEKNENLAKKRCSEELVKQERKYENTDNKTELGNSDLKGNL 521
Query: 295 ERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK----DQEK 350
+ Q + L S A+ E++ +K + + ++ + + + E E+ E K +Q+K
Sbjct: 522 KEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQK 581
Query: 351 VSQEIQKA-IQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKE 402
Q+++K IQEQ + + +I ++RS E K R+ +I KE
Sbjct: 582 KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKE 634
>gi|225579095 S-phase cyclin A-associated protein in the ER isoform
b [Homo sapiens]
Length = 1154
Score = 65.9 bits (159), Expect = 7e-11
Identities = 70/280 (25%), Positives = 136/280 (48%), Gaps = 26/280 (9%)
Query: 114 GTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSE-----EEKQRIKQDVESLMEKHNV 168
G I + + PG I + +K+SS K ++E EEKQ Q + + +
Sbjct: 264 GDIVEEEPARPPG---HGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKT 320
Query: 169 LEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQ 228
L+ L E+E++ +++ EL ++ ++ +E+ K H V + +A+++ + +++
Sbjct: 321 LKLQKLLEREKDVRKWKE---ELLDQRRRMMEE--KLLHAEFKREV-QLQAIVKKAQEEE 374
Query: 229 VEAIEKQYISAIEKQ--AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKE 286
+ E +I+ +E Q H L QRL E+ E+ +++ K+A + QE+K
Sbjct: 375 AKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNEL--QEERQRRQEEKQARDEAVQERK- 431
Query: 287 ILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK 346
+ LE ERQ E L+ K E+EA + + E+ R++ + A +RE
Sbjct: 432 ---RALEAERQARVEELLMKRK-EQEARIEQQRQEKEKAREDAARERARDREERLAALTA 487
Query: 347 DQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE 386
Q++ +E+QK IQ + E+++ + + ++R EKA E
Sbjct: 488 AQQEAMEELQKKIQLKH---DESIRRHMEQIEQRKEKAAE 524
Score = 55.5 bits (132), Expect = 1e-07
Identities = 73/304 (24%), Positives = 141/304 (46%), Gaps = 36/304 (11%)
Query: 133 QLQQKISSLE-IKL-KVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
QL++K+ + +KL K+ E EK K E L ++ ++E+ L + + + Q K+
Sbjct: 310 QLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKK 369
Query: 191 LQEKHKQELE-------DMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQ 243
QE+ + E + + H+ LS + + + L + ++Q EKQ A ++
Sbjct: 370 AQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ---ARDEA 426
Query: 244 AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKE-- 301
+ + L A+ Q +E L L+K K +EA I+Q +++KE + ER R++E
Sbjct: 427 VQERKRALEAERQARVEEL-----LMKRKEQEARIEQQRQEKEKAREDAARERARDREER 481
Query: 302 -ALVSAAKLE--KEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKA 358
A ++AA+ E +E K LK E R+++E+ E+R+ E + + + K
Sbjct: 482 LAALTAAQQEAMEELQKKIQLKHDESIRRHMEQ--IEQRKEKAAELSSGRHANTDYAPKL 539
Query: 359 IQEQRK---------ISQETVKAAIIEEQKRSEKAVEEAVKRTR---DELIEYIKEQKRL 406
+RK IS E + ++ +K + E + R DE +E++ +K +
Sbjct: 540 TPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYI 599
Query: 407 DQVI 410
++
Sbjct: 600 IDIV 603
Score = 52.0 bits (123), Expect = 1e-06
Identities = 55/253 (21%), Positives = 110/253 (43%), Gaps = 42/253 (16%)
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISA 239
E +S R + + E K+ E KA L+ ++++ + ++ Q +
Sbjct: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQ-------------LREKLREE-KTLKLQKLLE 328
Query: 240 IEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRN 299
EK K +E E+LD + +++EK+ A ++ + + I++K EEE + N
Sbjct: 329 REKDVRKWKE----------ELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN 378
Query: 300 KEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI 359
+ A ++ LE + + VL ++E + L + E + + + A+D+ A+
Sbjct: 379 EIAFINT--LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE---------AV 427
Query: 360 QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
QE RK + E + A +EE K E +++ R E ++K + R+R+ E
Sbjct: 428 QE-RKRALEAERQARVEELLMKRKEQEARIEQQRQE------KEKAREDAARERARDREE 480
Query: 420 LFLSCAQKQLSAL 432
+ Q A+
Sbjct: 481 RLAALTAAQQEAM 493
Score = 48.5 bits (114), Expect = 1e-05
Identities = 90/454 (19%), Positives = 191/454 (42%), Gaps = 90/454 (19%)
Query: 61 CLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD 120
CL D I + S ++ PK + H PL EK+ T++ +D
Sbjct: 58 CLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDH--------PLA---EKTQFTVSTLD 106
Query: 121 DSEDPGANVSNIQLQQKISSLEI--------------KLKVSEE----EKQRIKQDV--- 159
D ++ G+ N +IS++ I L+V+EE EK RI+ ++
Sbjct: 107 DVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPS 166
Query: 160 -------ESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMR--------- 203
E L +K + ++ +E A + + + +E +E D+
Sbjct: 167 DISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDF 226
Query: 204 --KAGHEALSI---------IVDEYKALLQSSVKQQV---EAIEKQYISAIEKQAHKCEE 249
G ++S ++ +Y+A + S +Q + +E++ H E+
Sbjct: 227 SASMGSGSVSFCGMSMDWNDVLADYEA--RESWRQNTSWGDIVEEEPARPPGHGIHMHEK 284
Query: 250 LLNAQHQRLL-------EMLDTEKELLKEKIKE-------ALIQQSQEQKEILEKCLEEE 295
L + +R + E + + L+EK++E L+++ ++ ++ E+ L++
Sbjct: 285 LSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQR 344
Query: 296 RQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEH-----AKDQEK 350
R+ +E L+ A + ++ V K EEE K E A E H K+ E+
Sbjct: 345 RRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQ 404
Query: 351 VSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVI 410
E+Q+ + QR+ ++ + ++E+KR+ +A +A R + L++ +++ R++Q
Sbjct: 405 RLNELQE--ERQRRQEEKQARDEAVQERKRALEAERQA--RVEELLMKRKEQEARIEQQR 460
Query: 411 RQRSLSSLELFLSCA---QKQLSALIATEPVDIE 441
+++ + + A +++L+AL A + +E
Sbjct: 461 QEKEKAREDAARERARDREERLAALTAAQQEAME 494
>gi|225579092 S-phase cyclin A-associated protein in the ER isoform
a [Homo sapiens]
Length = 1400
Score = 65.9 bits (159), Expect = 7e-11
Identities = 70/280 (25%), Positives = 136/280 (48%), Gaps = 26/280 (9%)
Query: 114 GTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSE-----EEKQRIKQDVESLMEKHNV 168
G I + + PG I + +K+SS K ++E EEKQ Q + + +
Sbjct: 510 GDIVEEEPARPPG---HGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKT 566
Query: 169 LEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQ 228
L+ L E+E++ +++ EL ++ ++ +E+ K H V + +A+++ + +++
Sbjct: 567 LKLQKLLEREKDVRKWKE---ELLDQRRRMMEE--KLLHAEFKREV-QLQAIVKKAQEEE 620
Query: 229 VEAIEKQYISAIEKQ--AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKE 286
+ E +I+ +E Q H L QRL E+ E+ +++ K+A + QE+K
Sbjct: 621 AKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNEL--QEERQRRQEEKQARDEAVQERK- 677
Query: 287 ILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAK 346
+ LE ERQ E L+ K E+EA + + E+ R++ + A +RE
Sbjct: 678 ---RALEAERQARVEELLMKRK-EQEARIEQQRQEKEKAREDAARERARDREERLAALTA 733
Query: 347 DQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVE 386
Q++ +E+QK IQ + E+++ + + ++R EKA E
Sbjct: 734 AQQEAMEELQKKIQLKH---DESIRRHMEQIEQRKEKAAE 770
Score = 55.5 bits (132), Expect = 1e-07
Identities = 73/304 (24%), Positives = 141/304 (46%), Gaps = 36/304 (11%)
Query: 133 QLQQKISSLE-IKL-KVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKE 190
QL++K+ + +KL K+ E EK K E L ++ ++E+ L + + + Q K+
Sbjct: 556 QLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKK 615
Query: 191 LQEKHKQELE-------DMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQ 243
QE+ + E + + H+ LS + + + L + ++Q EKQ A ++
Sbjct: 616 AQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ---ARDEA 672
Query: 244 AHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKE-- 301
+ + L A+ Q +E L L+K K +EA I+Q +++KE + ER R++E
Sbjct: 673 VQERKRALEAERQARVEEL-----LMKRKEQEARIEQQRQEKEKAREDAARERARDREER 727
Query: 302 -ALVSAAKLE--KEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKA 358
A ++AA+ E +E K LK E R+++E+ E+R+ E + + + K
Sbjct: 728 LAALTAAQQEAMEELQKKIQLKHDESIRRHMEQ--IEQRKEKAAELSSGRHANTDYAPKL 785
Query: 359 IQEQRK---------ISQETVKAAIIEEQKRSEKAVEEAVKRTR---DELIEYIKEQKRL 406
+RK IS E + ++ +K + E + R DE +E++ +K +
Sbjct: 786 TPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYI 845
Query: 407 DQVI 410
++
Sbjct: 846 IDIV 849
Score = 52.0 bits (123), Expect = 1e-06
Identities = 55/253 (21%), Positives = 110/253 (43%), Gaps = 42/253 (16%)
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISA 239
E +S R + + E K+ E KA L+ ++++ + ++ Q +
Sbjct: 529 EKLSSPSRKRTIAESKKKHEEKQMKAQQ-------------LREKLREE-KTLKLQKLLE 574
Query: 240 IEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRN 299
EK K +E E+LD + +++EK+ A ++ + + I++K EEE + N
Sbjct: 575 REKDVRKWKE----------ELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN 624
Query: 300 KEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAI 359
+ A ++ LE + + VL ++E + L + E + + + A+D+ A+
Sbjct: 625 EIAFINT--LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE---------AV 673
Query: 360 QEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLE 419
QE RK + E + A +EE K E +++ R E ++K + R+R+ E
Sbjct: 674 QE-RKRALEAERQARVEELLMKRKEQEARIEQQRQE------KEKAREDAARERARDREE 726
Query: 420 LFLSCAQKQLSAL 432
+ Q A+
Sbjct: 727 RLAALTAAQQEAM 739
Score = 48.5 bits (114), Expect = 1e-05
Identities = 90/454 (19%), Positives = 191/454 (42%), Gaps = 90/454 (19%)
Query: 61 CLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD 120
CL D I + S ++ PK + H PL EK+ T++ +D
Sbjct: 304 CLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDH--------PLA---EKTQFTVSTLD 352
Query: 121 DSEDPGANVSNIQLQQKISSLEI--------------KLKVSEE----EKQRIKQDV--- 159
D ++ G+ N +IS++ I L+V+EE EK RI+ ++
Sbjct: 353 DVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPS 412
Query: 160 -------ESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMR--------- 203
E L +K + ++ +E A + + + +E +E D+
Sbjct: 413 DISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDF 472
Query: 204 --KAGHEALSI---------IVDEYKALLQSSVKQQV---EAIEKQYISAIEKQAHKCEE 249
G ++S ++ +Y+A + S +Q + +E++ H E+
Sbjct: 473 SASMGSGSVSFCGMSMDWNDVLADYEA--RESWRQNTSWGDIVEEEPARPPGHGIHMHEK 530
Query: 250 LLNAQHQRLL-------EMLDTEKELLKEKIKE-------ALIQQSQEQKEILEKCLEEE 295
L + +R + E + + L+EK++E L+++ ++ ++ E+ L++
Sbjct: 531 LSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQR 590
Query: 296 RQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEH-----AKDQEK 350
R+ +E L+ A + ++ V K EEE K E A E H K+ E+
Sbjct: 591 RRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQ 650
Query: 351 VSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVI 410
E+Q+ + QR+ ++ + ++E+KR+ +A +A R + L++ +++ R++Q
Sbjct: 651 RLNELQE--ERQRRQEEKQARDEAVQERKRALEAERQA--RVEELLMKRKEQEARIEQQR 706
Query: 411 RQRSLSSLELFLSCA---QKQLSALIATEPVDIE 441
+++ + + A +++L+AL A + +E
Sbjct: 707 QEKEKAREDAARERARDREERLAALTAAQQEAME 740
>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
sapiens]
Length = 796
Score = 65.9 bits (159), Expect = 7e-11
Identities = 93/388 (23%), Positives = 169/388 (43%), Gaps = 73/388 (18%)
Query: 66 AIISSPENTHAANSIVSQTIPKAQ-IQQSTHTHLDISLFPLGLTDEKSN----------G 114
+IIS E T NS+ Q + K Q +Q + I + L E N
Sbjct: 369 SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 428
Query: 115 TIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFL 174
T +L+ E + N L ++ S+++ KL +EE + ++ + ++ K+NVL
Sbjct: 429 TQSLIQKVETYEKQLKN--LVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL----- 481
Query: 175 KEKEQEAISFQDRYKELQEKHKQ---ELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEA 231
Q + K L+EK+ Q E + M +A +D+ K+ +
Sbjct: 482 ----------QGQNKTLEEKNIQLSLEKQQMMEA--------LDQLKSKEHKTQSDMAIV 523
Query: 232 IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKC 291
+ +IE +A K LL + EKE+L++K + L ++S E+ E
Sbjct: 524 NNENNRMSIEMEAMKTNILL----------IQDEKEMLEKKTHQLLKEKSSLGNELKESQ 573
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAE--------EREL--WK 341
LE + + KE L AK E+E + +++ V++E+ NLE E ERE+ +
Sbjct: 574 LEIIQLKEKERL---AKTEQETLLQ-IIETVKDEKLNLETTLQESTAARQIMEREIENIQ 629
Query: 342 TEHAKDQEKVSQEIQKAIQEQ-------RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTR 393
T + +E QEI+ A E +I +E + + ++ E K + ++E +K+
Sbjct: 630 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 689
Query: 394 DELIEYIKEQKRL--DQVIRQRSLSSLE 419
E I++ RL D+++ + + S+E
Sbjct: 690 QENIKFENSISRLTEDKILLENYVRSIE 717
>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
sapiens]
Length = 833
Score = 65.9 bits (159), Expect = 7e-11
Identities = 93/388 (23%), Positives = 169/388 (43%), Gaps = 73/388 (18%)
Query: 66 AIISSPENTHAANSIVSQTIPKAQ-IQQSTHTHLDISLFPLGLTDEKSN----------G 114
+IIS E T NS+ Q + K Q +Q + I + L E N
Sbjct: 406 SIISENEKTSKVNSVTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKMKPLIFT 465
Query: 115 TIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFL 174
T +L+ E + N L ++ S+++ KL +EE + ++ + ++ K+NVL
Sbjct: 466 TQSLIQKVETYEKQLKN--LVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVL----- 518
Query: 175 KEKEQEAISFQDRYKELQEKHKQ---ELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEA 231
Q + K L+EK+ Q E + M +A +D+ K+ +
Sbjct: 519 ----------QGQNKTLEEKNIQLSLEKQQMMEA--------LDQLKSKEHKTQSDMAIV 560
Query: 232 IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKC 291
+ +IE +A K LL + EKE+L++K + L ++S E+ E
Sbjct: 561 NNENNRMSIEMEAMKTNILL----------IQDEKEMLEKKTHQLLKEKSSLGNELKESQ 610
Query: 292 LEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAE--------EREL--WK 341
LE + + KE L AK E+E + +++ V++E+ NLE E ERE+ +
Sbjct: 611 LEIIQLKEKERL---AKTEQETLLQ-IIETVKDEKLNLETTLQESTAARQIMEREIENIQ 666
Query: 342 TEHAKDQEKVSQEIQKAIQEQ-------RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTR 393
T + +E QEI+ A E +I +E + + ++ E K + ++E +K+
Sbjct: 667 TYQSTAEENFLQEIKNAKSEASIYKNSLSEIGKECEMLSKMVMETKTDNQILKEELKKHS 726
Query: 394 DELIEYIKEQKRL--DQVIRQRSLSSLE 419
E I++ RL D+++ + + S+E
Sbjct: 727 QENIKFENSISRLTEDKILLENYVRSIE 754
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/370 (21%), Positives = 166/370 (44%), Gaps = 43/370 (11%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E N + L D + ++++ +L V+ +E R++Q E + + L
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 170 EKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+ LKEK Q EA Q + KEL ++ + L++ ++ + L+ ++
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 220 LLQSSVKQQVEA--------IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE 271
L++ ++Q+E + +S + +A + + Q + + E L + +E
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 272 KIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL---EKEAVKDAVLKVVE 323
K+ E QQS E L + + E +R KE L AKL + E ++ + +
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 324 EERKNLEKAHAEERE-LWKTEHAKDQEKVS------QEIQKAIQ-------EQRKISQET 369
+E + L+++ E++ L + E +QEK E+ KA Q +Q+++ QE
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2545
Query: 370 VK-AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
+ A +EE +R + EE V+R ++EL + +++++ ++++ + + E ++
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 429 LSALIATEPV 438
+AL +E V
Sbjct: 2606 RAALAHSEEV 2615
Score = 64.3 bits (155), Expect = 2e-10
Identities = 65/313 (20%), Positives = 147/313 (46%), Gaps = 40/313 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q ++ + + +EEE++R ++ E ++K E +EA + E E+
Sbjct: 1964 QAELEAARQRQLAAEEERRR--REAEERVQKSLAAE--------EEAARQRKAALEEVER 2013
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K ++E+ R+ A + + L Q + +++++A EK + A++++ + ++ L Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-Q 2071
Query: 255 HQRLLEMLDTEKELLK---EKIKEALIQQSQE---------QKEILEKCLEEERQRNKEA 302
Q +L+ L E E + E+ +EA +Q +E + E L++ EE+ Q +A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+A KL KEA ++A + E+ +K A+ + EK + ++ ++++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD----------AEMEKHKKFAEQTLRQK 2181
Query: 363 RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV-----IRQRSLS 416
++ QE T +EE + ++E ++R + E E +++ ++++ ++ LS
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 417 SLELFLSCAQKQL 429
L+ + + L
Sbjct: 2242 KLKARIEAENRAL 2254
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/331 (22%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV---LEKGFLKEKEQ 179
E A +L+ +++ + +++V K R +++ S EK E G +E +
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYIS 238
EA + +E + + + ED + EA ++ ++ A+ +++ +K + E K+ +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 239 AIEK----------QAHKCEELLNAQHQ--------RLLEMLDTEKELLKEKIKEALIQQ 280
E+ Q + EE AQH+ +L + D+E E K +++ L Q+
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 281 SQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELW 340
Q ++EIL E+ +A K E E + E+ ++ E+A E
Sbjct: 1921 RQVEEEILALKASFEK-------AAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-- 1971
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
+ + A ++E+ +E ++ +Q+ A EE R KA E V+R + + +
Sbjct: 1972 QRQLAAEEERRRREAEERVQK---------SLAAEEEAARQRKAALEEVERLKAK----V 2018
Query: 401 KEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+E +RL + Q S L+L AQK+L A
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/307 (18%), Positives = 140/307 (45%), Gaps = 17/307 (5%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ- 192
L+ + E + + ++EE +R+++ V+ ++ E + EA + +++ + LQ
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 193 -EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
E+ + + E+ + +A + + L+++ + ++ + S EK A + E L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSL 1596
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK--EILEKCLEEERQRNKEALVSAAKL 309
+H + + L+E+ + QQ++ ++ E E+ LE + + EAL +
Sbjct: 1597 QEEHVAVAQ--------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E+ A + ++ + E++K + A R + + + +E QE++K QR++++ T
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQL 429
+ + EQ+ E + +L+E + + + + LE L+ + ++
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 430 SALIATE 436
L+A++
Sbjct: 1765 EVLLASK 1771
Score = 51.6 bits (122), Expect = 1e-06
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 13/289 (4%)
Query: 151 EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL 210
E R+K + E +++ + + E EA + R +E +HK ++E+ +A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 211 SIIVDEYKALLQSSVKQ--QVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ K L++ +++Q QVE ++ EK A EL + DT +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV-LKV-VEEER 326
+ +++ A +Q ++E + EE Q++ A AA+ K A+++ LK VEE R
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 327 KNLEKAHAEE-RELWKTEHAKDQEKVSQEIQKAI---QEQRKISQETVKAAIIEEQKRSE 382
+ E+A E R+L + A + ++E A Q+++++ Q + + +Q R E
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 383 KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
EA +R +E E + Q + +R + E A++Q A
Sbjct: 2083 ---AEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/259 (24%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----------EQEAI 182
+LQQ+ L++K EE Q ++Q E L+++ L++ FL EK EQE
Sbjct: 2461 KLQQEAKLLQLK----SEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 183 S----FQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
FQD + Q+ +++ ++ E ++ +A + ++ +++ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
+E+Q + EELL ++QRL E L +LL+E+ + AL E+ + +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQL----QLLEEQHRAALAH--SEEVTASQVAATKTLPN 2628
Query: 299 NKEALVS-AAKLEKEAVKDAVLKVVEEERKNLEKA---HAEERELWKTEHAKDQEKVSQE 354
++AL AA+ E E D + + V +R L++A AEE + H E +E
Sbjct: 2629 GRDALDGPAAEAEPEHSFDGLRRKVSAQR--LQEAGILSAEELQRLAQGHTTVDELARRE 2686
Query: 355 -IQKAIQEQRKISQETVKA 372
++ +Q + I+ +KA
Sbjct: 2687 DVRHYLQGRSSIAGLLLKA 2705
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/310 (21%), Positives = 131/310 (42%), Gaps = 59/310 (19%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLE---KGFLKEKEQEAISFQDRYKELQEKHKQE 198
E++L+ E E++ + +VE + LE + E + + SF ++ +L+ ++E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---- 254
+ + EA E +A Q+ ++ E E++ +E+ K E L +
Sbjct: 1600 HVAVAQLREEA------ERRAQQQAEAERAREEAERE----LERWQLKANEALRLRLQAE 1649
Query: 255 ---HQRLLEMLDTEKELLKEKIKEA-----LIQQSQEQKEILEKCLEEERQRNKEALVSA 306
Q+ L + EK+ +E +EA +Q+ Q+E+ E+ LE++RQ +
Sbjct: 1650 EVAQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 307 AKLEKEAVK--------DAVLKVVEEERKNLEK---AHAEERELWKTEHAK--------- 346
E+E ++ + +++EEE L++ A ++R+ + E AK
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 347 ------------DQEKVSQEIQKAIQEQRKISQETVK-AAIIEEQKRSEKAVEEAVKRTR 393
EK Q ++ R++++E + A+ EE KR + EE R R
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828
Query: 394 DELIEYIKEQ 403
E + E+
Sbjct: 1829 AEAERVLAEK 1838
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/222 (21%), Positives = 107/222 (48%), Gaps = 37/222 (16%)
Query: 193 EKHKQELEDMRKAGHEALSIIVD------EYKALLQS--------SVKQQVEAIEKQYIS 238
E+H +++E+ ++ + ++ I D YKA L+ V+ E++ ++Y+
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV- 1317
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI--LEKCLEEER 296
+ + H E L + ++ + ++E+ + A Q+++E++ + +E LE++R
Sbjct: 1318 --DLRTHYSE--LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
Q + + A+ E+EA K L++ +E + + E A D ++ + IQ
Sbjct: 1374 QLAEAHAQAKAQAEREA-------------KELQQ-RMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 357 KAIQEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDEL 396
+ +Q+ R+ S+ + KA E +RS +EE ++ R +L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Score = 39.7 bits (91), Expect = 0.006
Identities = 82/394 (20%), Positives = 174/394 (44%), Gaps = 49/394 (12%)
Query: 60 GCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALV 119
G ++ ++ + E V T+P+ + ++ SL L E T +
Sbjct: 1097 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-------SLKKLRAQAEAQQPTFDAL 1149
Query: 120 DDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN-VLEKGFLKEKE 178
D E GA +LQQ+ ++ E +R ++ V L+E+ VL + ++++E
Sbjct: 1150 RD-ELRGAQEVGERLQQRHGERDV-------EVERWRERVAQLLERWQAVLAQTDVRQRE 1201
Query: 179 QEAISFQDRY-KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
E + Q RY +E + L+D R+ + ++ + + +A V++Q+ E+ +
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-----VREQLRQ-EQALL 1255
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL---EKCLEE 294
IE+ K EE Q + + D E +L+ K + + ++ ++ E ++E
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 295 --ERQRNKEALVSAAKLEKEAVKDAVLKVVEEER----------KNL---EKAHAEEREL 339
+ + + L + + + + + ++ EEER + L E A ++R+L
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 340 WKTE-HAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI 397
+ AK Q E+ ++E+Q+ +QE+ + + A ++QKRS ++E +++ R
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEE--VVRREEAAVDAQQQKRS---IQEELQQLRQSSE 1430
Query: 398 EYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
I+ + R + +RS +E + + QL A
Sbjct: 1431 AEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEA 1463
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/370 (21%), Positives = 166/370 (44%), Gaps = 43/370 (11%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E N + L D + ++++ +L V+ +E R++Q E + + L
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 170 EKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+ LKEK Q EA Q + KEL ++ + L++ ++ + L+ ++
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEETQGFQR 2370
Query: 220 LLQSSVKQQVEA--------IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE 271
L++ ++Q+E + +S + +A + + Q + + E L + +E
Sbjct: 2371 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Query: 272 KIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL---EKEAVKDAVLKVVE 323
K+ E QQS E L + + E +R KE L AKL + E ++ + +
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489
Query: 324 EERKNLEKAHAEERE-LWKTEHAKDQEKVS------QEIQKAIQ-------EQRKISQET 369
+E + L+++ E++ L + E +QEK E+ KA Q +Q+++ QE
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2549
Query: 370 VK-AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
+ A +EE +R + EE V+R ++EL + +++++ ++++ + + E ++
Sbjct: 2550 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Query: 429 LSALIATEPV 438
+AL +E V
Sbjct: 2610 RAALAHSEEV 2619
Score = 64.3 bits (155), Expect = 2e-10
Identities = 65/313 (20%), Positives = 147/313 (46%), Gaps = 40/313 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q ++ + + +EEE++R ++ E ++K E +EA + E E+
Sbjct: 1968 QAELEAARQRQLAAEEERRR--REAEERVQKSLAAE--------EEAARQRKAALEEVER 2017
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K ++E+ R+ A + + L Q + +++++A EK + A++++ + ++ L Q
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-Q 2075
Query: 255 HQRLLEMLDTEKELLK---EKIKEALIQQSQE---------QKEILEKCLEEERQRNKEA 302
Q +L+ L E E + E+ +EA +Q +E + E L++ EE+ Q +A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+A KL KEA ++A + E+ +K A+ + EK + ++ ++++
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD----------AEMEKHKKFAEQTLRQK 2185
Query: 363 RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV-----IRQRSLS 416
++ QE T +EE + ++E ++R + E E +++ ++++ ++ LS
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 417 SLELFLSCAQKQL 429
L+ + + L
Sbjct: 2246 KLKARIEAENRAL 2258
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/331 (22%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV---LEKGFLKEKEQ 179
E A +L+ +++ + +++V K R +++ S EK E G +E +
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYIS 238
EA + +E + + + ED + EA ++ ++ A+ +++ +K + E K+ +
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 239 AIEK----------QAHKCEELLNAQHQ--------RLLEMLDTEKELLKEKIKEALIQQ 280
E+ Q + EE AQH+ +L + D+E E K +++ L Q+
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 281 SQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELW 340
Q ++EIL E+ +A K E E + E+ ++ E+A E
Sbjct: 1925 RQVEEEILALKASFEK-------AAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-- 1975
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
+ + A ++E+ +E ++ +Q+ A EE R KA E V+R + + +
Sbjct: 1976 QRQLAAEEERRRREAEERVQK---------SLAAEEEAARQRKAALEEVERLKAK----V 2022
Query: 401 KEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+E +RL + Q S L+L AQK+L A
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/307 (18%), Positives = 140/307 (45%), Gaps = 17/307 (5%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ- 192
L+ + E + + ++EE +R+++ V+ ++ E + EA + +++ + LQ
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 193 -EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
E+ + + E+ + +A + + L+++ + ++ + S EK A + E L
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSL 1600
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK--EILEKCLEEERQRNKEALVSAAKL 309
+H + + L+E+ + QQ++ ++ E E+ LE + + EAL +
Sbjct: 1601 QEEHVAVAQ--------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E+ A + ++ + E++K + A R + + + +E QE++K QR++++ T
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1708
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQL 429
+ + EQ+ E + +L+E + + + + LE L+ + ++
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 430 SALIATE 436
L+A++
Sbjct: 1769 EVLLASK 1775
Score = 51.6 bits (122), Expect = 1e-06
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 13/289 (4%)
Query: 151 EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL 210
E R+K + E +++ + + E EA + R +E +HK ++E+ +A
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 211 SIIVDEYKALLQSSVKQ--QVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ K L++ +++Q QVE ++ EK A EL + DT +
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV-LKV-VEEER 326
+ +++ A +Q ++E + EE Q++ A AA+ K A+++ LK VEE R
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026
Query: 327 KNLEKAHAEE-RELWKTEHAKDQEKVSQEIQKAI---QEQRKISQETVKAAIIEEQKRSE 382
+ E+A E R+L + A + ++E A Q+++++ Q + + +Q R E
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086
Query: 383 KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
EA +R +E E + Q + +R + E A++Q A
Sbjct: 2087 ---AEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/259 (24%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----------EQEAI 182
+LQQ+ L++K EE Q ++Q E L+++ L++ FL EK EQE
Sbjct: 2465 KLQQEAKLLQLK----SEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 183 S----FQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
FQD + Q+ +++ ++ E ++ +A + ++ +++ +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
+E+Q + EELL ++QRL E L +LL+E+ + AL E+ + +
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQL----QLLEEQHRAALAH--SEEVTASQVAATKTLPN 2632
Query: 299 NKEALVS-AAKLEKEAVKDAVLKVVEEERKNLEKA---HAEERELWKTEHAKDQEKVSQE 354
++AL AA+ E E D + + V +R L++A AEE + H E +E
Sbjct: 2633 GRDALDGPAAEAEPEHSFDGLRRKVSAQR--LQEAGILSAEELQRLAQGHTTVDELARRE 2690
Query: 355 -IQKAIQEQRKISQETVKA 372
++ +Q + I+ +KA
Sbjct: 2691 DVRHYLQGRSSIAGLLLKA 2709
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/310 (21%), Positives = 131/310 (42%), Gaps = 59/310 (19%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLE---KGFLKEKEQEAISFQDRYKELQEKHKQE 198
E++L+ E E++ + +VE + LE + E + + SF ++ +L+ ++E
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---- 254
+ + EA E +A Q+ ++ E E++ +E+ K E L +
Sbjct: 1604 HVAVAQLREEA------ERRAQQQAEAERAREEAERE----LERWQLKANEALRLRLQAE 1653
Query: 255 ---HQRLLEMLDTEKELLKEKIKEA-----LIQQSQEQKEILEKCLEEERQRNKEALVSA 306
Q+ L + EK+ +E +EA +Q+ Q+E+ E+ LE++RQ +
Sbjct: 1654 EVAQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 307 AKLEKEAVK--------DAVLKVVEEERKNLEK---AHAEERELWKTEHAK--------- 346
E+E ++ + +++EEE L++ A ++R+ + E AK
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 347 ------------DQEKVSQEIQKAIQEQRKISQETVK-AAIIEEQKRSEKAVEEAVKRTR 393
EK Q ++ R++++E + A+ EE KR + EE R R
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1832
Query: 394 DELIEYIKEQ 403
E + E+
Sbjct: 1833 AEAERVLAEK 1842
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/222 (21%), Positives = 107/222 (48%), Gaps = 37/222 (16%)
Query: 193 EKHKQELEDMRKAGHEALSIIVD------EYKALLQS--------SVKQQVEAIEKQYIS 238
E+H +++E+ ++ + ++ I D YKA L+ V+ E++ ++Y+
Sbjct: 1263 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV- 1321
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI--LEKCLEEER 296
+ + H E L + ++ + ++E+ + A Q+++E++ + +E LE++R
Sbjct: 1322 --DLRTHYSE--LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1377
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
Q + + A+ E+EA K L++ +E + + E A D ++ + IQ
Sbjct: 1378 QLAEAHAQAKAQAEREA-------------KELQQ-RMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 357 KAIQEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDEL 396
+ +Q+ R+ S+ + KA E +RS +EE ++ R +L
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Score = 39.7 bits (91), Expect = 0.006
Identities = 82/394 (20%), Positives = 174/394 (44%), Gaps = 49/394 (12%)
Query: 60 GCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALV 119
G ++ ++ + E V T+P+ + ++ SL L E T +
Sbjct: 1101 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-------SLKKLRAQAEAQQPTFDAL 1153
Query: 120 DDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN-VLEKGFLKEKE 178
D E GA +LQQ+ ++ E +R ++ V L+E+ VL + ++++E
Sbjct: 1154 RD-ELRGAQEVGERLQQRHGERDV-------EVERWRERVAQLLERWQAVLAQTDVRQRE 1205
Query: 179 QEAISFQDRY-KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
E + Q RY +E + L+D R+ + ++ + + +A V++Q+ E+ +
Sbjct: 1206 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-----VREQLRQ-EQALL 1259
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL---EKCLEE 294
IE+ K EE Q + + D E +L+ K + + ++ ++ E ++E
Sbjct: 1260 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1319
Query: 295 --ERQRNKEALVSAAKLEKEAVKDAVLKVVEEER----------KNL---EKAHAEEREL 339
+ + + L + + + + + ++ EEER + L E A ++R+L
Sbjct: 1320 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 340 WKTE-HAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI 397
+ AK Q E+ ++E+Q+ +QE+ + + A ++QKRS ++E +++ R
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEE--VVRREEAAVDAQQQKRS---IQEELQQLRQSSE 1434
Query: 398 EYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
I+ + R + +RS +E + + QL A
Sbjct: 1435 AEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEA 1467
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/370 (21%), Positives = 166/370 (44%), Gaps = 43/370 (11%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E N + L D + ++++ +L V+ +E R++Q E + + L
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 170 EKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+ LKEK Q EA Q + KEL ++ + L++ ++ + L+ ++
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 220 LLQSSVKQQVEA--------IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE 271
L++ ++Q+E + +S + +A + + Q + + E L + +E
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 272 KIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL---EKEAVKDAVLKVVE 323
K+ E QQS E L + + E +R KE L AKL + E ++ + +
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 324 EERKNLEKAHAEERE-LWKTEHAKDQEKVS------QEIQKAIQ-------EQRKISQET 369
+E + L+++ E++ L + E +QEK E+ KA Q +Q+++ QE
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2545
Query: 370 VK-AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
+ A +EE +R + EE V+R ++EL + +++++ ++++ + + E ++
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 429 LSALIATEPV 438
+AL +E V
Sbjct: 2606 RAALAHSEEV 2615
Score = 64.3 bits (155), Expect = 2e-10
Identities = 65/313 (20%), Positives = 147/313 (46%), Gaps = 40/313 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q ++ + + +EEE++R ++ E ++K E +EA + E E+
Sbjct: 1964 QAELEAARQRQLAAEEERRR--REAEERVQKSLAAE--------EEAARQRKAALEEVER 2013
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K ++E+ R+ A + + L Q + +++++A EK + A++++ + ++ L Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-Q 2071
Query: 255 HQRLLEMLDTEKELLK---EKIKEALIQQSQE---------QKEILEKCLEEERQRNKEA 302
Q +L+ L E E + E+ +EA +Q +E + E L++ EE+ Q +A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+A KL KEA ++A + E+ +K A+ + EK + ++ ++++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD----------AEMEKHKKFAEQTLRQK 2181
Query: 363 RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV-----IRQRSLS 416
++ QE T +EE + ++E ++R + E E +++ ++++ ++ LS
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 417 SLELFLSCAQKQL 429
L+ + + L
Sbjct: 2242 KLKARIEAENRAL 2254
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/331 (22%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV---LEKGFLKEKEQ 179
E A +L+ +++ + +++V K R +++ S EK E G +E +
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYIS 238
EA + +E + + + ED + EA ++ ++ A+ +++ +K + E K+ +
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 239 AIEK----------QAHKCEELLNAQHQ--------RLLEMLDTEKELLKEKIKEALIQQ 280
E+ Q + EE AQH+ +L + D+E E K +++ L Q+
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 281 SQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELW 340
Q ++EIL E+ +A K E E + E+ ++ E+A E
Sbjct: 1921 RQVEEEILALKASFEK-------AAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-- 1971
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
+ + A ++E+ +E ++ +Q+ A EE R KA E V+R + + +
Sbjct: 1972 QRQLAAEEERRRREAEERVQK---------SLAAEEEAARQRKAALEEVERLKAK----V 2018
Query: 401 KEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+E +RL + Q S L+L AQK+L A
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/307 (18%), Positives = 140/307 (45%), Gaps = 17/307 (5%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ- 192
L+ + E + + ++EE +R+++ V+ ++ E + EA + +++ + LQ
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 193 -EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
E+ + + E+ + +A + + L+++ + ++ + S EK A + E L
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSL 1596
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK--EILEKCLEEERQRNKEALVSAAKL 309
+H + + L+E+ + QQ++ ++ E E+ LE + + EAL +
Sbjct: 1597 QEEHVAVAQ--------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E+ A + ++ + E++K + A R + + + +E QE++K QR++++ T
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQL 429
+ + EQ+ E + +L+E + + + + LE L+ + ++
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 430 SALIATE 436
L+A++
Sbjct: 1765 EVLLASK 1771
Score = 51.6 bits (122), Expect = 1e-06
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 13/289 (4%)
Query: 151 EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL 210
E R+K + E +++ + + E EA + R +E +HK ++E+ +A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 211 SIIVDEYKALLQSSVKQ--QVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ K L++ +++Q QVE ++ EK A EL + DT +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV-LKV-VEEER 326
+ +++ A +Q ++E + EE Q++ A AA+ K A+++ LK VEE R
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 327 KNLEKAHAEE-RELWKTEHAKDQEKVSQEIQKAI---QEQRKISQETVKAAIIEEQKRSE 382
+ E+A E R+L + A + ++E A Q+++++ Q + + +Q R E
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 383 KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
EA +R +E E + Q + +R + E A++Q A
Sbjct: 2083 ---AEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/259 (24%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----------EQEAI 182
+LQQ+ L++K EE Q ++Q E L+++ L++ FL EK EQE
Sbjct: 2461 KLQQEAKLLQLK----SEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 183 S----FQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
FQD + Q+ +++ ++ E ++ +A + ++ +++ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
+E+Q + EELL ++QRL E L +LL+E+ + AL E+ + +
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQL----QLLEEQHRAALAH--SEEVTASQVAATKTLPN 2628
Query: 299 NKEALVS-AAKLEKEAVKDAVLKVVEEERKNLEKA---HAEERELWKTEHAKDQEKVSQE 354
++AL AA+ E E D + + V +R L++A AEE + H E +E
Sbjct: 2629 GRDALDGPAAEAEPEHSFDGLRRKVSAQR--LQEAGILSAEELQRLAQGHTTVDELARRE 2686
Query: 355 -IQKAIQEQRKISQETVKA 372
++ +Q + I+ +KA
Sbjct: 2687 DVRHYLQGRSSIAGLLLKA 2705
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/310 (21%), Positives = 131/310 (42%), Gaps = 59/310 (19%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLE---KGFLKEKEQEAISFQDRYKELQEKHKQE 198
E++L+ E E++ + +VE + LE + E + + SF ++ +L+ ++E
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---- 254
+ + EA E +A Q+ ++ E E++ +E+ K E L +
Sbjct: 1600 HVAVAQLREEA------ERRAQQQAEAERAREEAERE----LERWQLKANEALRLRLQAE 1649
Query: 255 ---HQRLLEMLDTEKELLKEKIKEA-----LIQQSQEQKEILEKCLEEERQRNKEALVSA 306
Q+ L + EK+ +E +EA +Q+ Q+E+ E+ LE++RQ +
Sbjct: 1650 EVAQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 307 AKLEKEAVK--------DAVLKVVEEERKNLEK---AHAEERELWKTEHAK--------- 346
E+E ++ + +++EEE L++ A ++R+ + E AK
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 347 ------------DQEKVSQEIQKAIQEQRKISQETVK-AAIIEEQKRSEKAVEEAVKRTR 393
EK Q ++ R++++E + A+ EE KR + EE R R
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1828
Query: 394 DELIEYIKEQ 403
E + E+
Sbjct: 1829 AEAERVLAEK 1838
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/222 (21%), Positives = 107/222 (48%), Gaps = 37/222 (16%)
Query: 193 EKHKQELEDMRKAGHEALSIIVD------EYKALLQS--------SVKQQVEAIEKQYIS 238
E+H +++E+ ++ + ++ I D YKA L+ V+ E++ ++Y+
Sbjct: 1259 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV- 1317
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI--LEKCLEEER 296
+ + H E L + ++ + ++E+ + A Q+++E++ + +E LE++R
Sbjct: 1318 --DLRTHYSE--LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
Q + + A+ E+EA K L++ +E + + E A D ++ + IQ
Sbjct: 1374 QLAEAHAQAKAQAEREA-------------KELQQ-RMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 357 KAIQEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDEL 396
+ +Q+ R+ S+ + KA E +RS +EE ++ R +L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Score = 39.7 bits (91), Expect = 0.006
Identities = 82/394 (20%), Positives = 174/394 (44%), Gaps = 49/394 (12%)
Query: 60 GCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALV 119
G ++ ++ + E V T+P+ + ++ SL L E T +
Sbjct: 1097 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-------SLKKLRAQAEAQQPTFDAL 1149
Query: 120 DDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN-VLEKGFLKEKE 178
D E GA +LQQ+ ++ E +R ++ V L+E+ VL + ++++E
Sbjct: 1150 RD-ELRGAQEVGERLQQRHGERDV-------EVERWRERVAQLLERWQAVLAQTDVRQRE 1201
Query: 179 QEAISFQDRY-KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
E + Q RY +E + L+D R+ + ++ + + +A V++Q+ E+ +
Sbjct: 1202 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-----VREQLRQ-EQALL 1255
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL---EKCLEE 294
IE+ K EE Q + + D E +L+ K + + ++ ++ E ++E
Sbjct: 1256 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1315
Query: 295 --ERQRNKEALVSAAKLEKEAVKDAVLKVVEEER----------KNL---EKAHAEEREL 339
+ + + L + + + + + ++ EEER + L E A ++R+L
Sbjct: 1316 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 340 WKTE-HAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI 397
+ AK Q E+ ++E+Q+ +QE+ + + A ++QKRS ++E +++ R
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEE--VVRREEAAVDAQQQKRS---IQEELQQLRQSSE 1430
Query: 398 EYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
I+ + R + +RS +E + + QL A
Sbjct: 1431 AEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEA 1463
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/370 (21%), Positives = 166/370 (44%), Gaps = 43/370 (11%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E N + L D + ++++ +L V+ +E R++Q E + + L
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 170 EKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+ LKEK Q EA Q + KEL ++ + L++ ++ + L+ ++
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEETQGFQR 2334
Query: 220 LLQSSVKQQVEA--------IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE 271
L++ ++Q+E + +S + +A + + Q + + E L + +E
Sbjct: 2335 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Query: 272 KIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL---EKEAVKDAVLKVVE 323
K+ E QQS E L + + E +R KE L AKL + E ++ + +
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453
Query: 324 EERKNLEKAHAEERE-LWKTEHAKDQEKVS------QEIQKAIQ-------EQRKISQET 369
+E + L+++ E++ L + E +QEK E+ KA Q +Q+++ QE
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2513
Query: 370 VK-AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
+ A +EE +R + EE V+R ++EL + +++++ ++++ + + E ++
Sbjct: 2514 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Query: 429 LSALIATEPV 438
+AL +E V
Sbjct: 2574 RAALAHSEEV 2583
Score = 64.3 bits (155), Expect = 2e-10
Identities = 65/313 (20%), Positives = 147/313 (46%), Gaps = 40/313 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q ++ + + +EEE++R ++ E ++K E +EA + E E+
Sbjct: 1932 QAELEAARQRQLAAEEERRR--REAEERVQKSLAAE--------EEAARQRKAALEEVER 1981
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K ++E+ R+ A + + L Q + +++++A EK + A++++ + ++ L Q
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-Q 2039
Query: 255 HQRLLEMLDTEKELLK---EKIKEALIQQSQE---------QKEILEKCLEEERQRNKEA 302
Q +L+ L E E + E+ +EA +Q +E + E L++ EE+ Q +A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+A KL KEA ++A + E+ +K A+ + EK + ++ ++++
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD----------AEMEKHKKFAEQTLRQK 2149
Query: 363 RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV-----IRQRSLS 416
++ QE T +EE + ++E ++R + E E +++ ++++ ++ LS
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 417 SLELFLSCAQKQL 429
L+ + + L
Sbjct: 2210 KLKARIEAENRAL 2222
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/331 (22%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV---LEKGFLKEKEQ 179
E A +L+ +++ + +++V K R +++ S EK E G +E +
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYIS 238
EA + +E + + + ED + EA ++ ++ A+ +++ +K + E K+ +
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 239 AIEK----------QAHKCEELLNAQHQ--------RLLEMLDTEKELLKEKIKEALIQQ 280
E+ Q + EE AQH+ +L + D+E E K +++ L Q+
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 281 SQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELW 340
Q ++EIL E+ +A K E E + E+ ++ E+A E
Sbjct: 1889 RQVEEEILALKASFEK-------AAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-- 1939
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
+ + A ++E+ +E ++ +Q+ A EE R KA E V+R + + +
Sbjct: 1940 QRQLAAEEERRRREAEERVQK---------SLAAEEEAARQRKAALEEVERLKAK----V 1986
Query: 401 KEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+E +RL + Q S L+L AQK+L A
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/307 (18%), Positives = 140/307 (45%), Gaps = 17/307 (5%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ- 192
L+ + E + + ++EE +R+++ V+ ++ E + EA + +++ + LQ
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 193 -EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
E+ + + E+ + +A + + L+++ + ++ + S EK A + E L
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSL 1564
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK--EILEKCLEEERQRNKEALVSAAKL 309
+H + + L+E+ + QQ++ ++ E E+ LE + + EAL +
Sbjct: 1565 QEEHVAVAQ--------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E+ A + ++ + E++K + A R + + + +E QE++K QR++++ T
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1672
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQL 429
+ + EQ+ E + +L+E + + + + LE L+ + ++
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732
Query: 430 SALIATE 436
L+A++
Sbjct: 1733 EVLLASK 1739
Score = 51.6 bits (122), Expect = 1e-06
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 13/289 (4%)
Query: 151 EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL 210
E R+K + E +++ + + E EA + R +E +HK ++E+ +A
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 211 SIIVDEYKALLQSSVKQ--QVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ K L++ +++Q QVE ++ EK A EL + DT +
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV-LKV-VEEER 326
+ +++ A +Q ++E + EE Q++ A AA+ K A+++ LK VEE R
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990
Query: 327 KNLEKAHAEE-RELWKTEHAKDQEKVSQEIQKAI---QEQRKISQETVKAAIIEEQKRSE 382
+ E+A E R+L + A + ++E A Q+++++ Q + + +Q R E
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050
Query: 383 KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
EA +R +E E + Q + +R + E A++Q A
Sbjct: 2051 ---AEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/259 (24%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----------EQEAI 182
+LQQ+ L++K EE Q ++Q E L+++ L++ FL EK EQE
Sbjct: 2429 KLQQEAKLLQLK----SEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 183 S----FQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
FQD + Q+ +++ ++ E ++ +A + ++ +++ +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
+E+Q + EELL ++QRL E L +LL+E+ + AL E+ + +
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQL----QLLEEQHRAALAH--SEEVTASQVAATKTLPN 2596
Query: 299 NKEALVS-AAKLEKEAVKDAVLKVVEEERKNLEKA---HAEERELWKTEHAKDQEKVSQE 354
++AL AA+ E E D + + V +R L++A AEE + H E +E
Sbjct: 2597 GRDALDGPAAEAEPEHSFDGLRRKVSAQR--LQEAGILSAEELQRLAQGHTTVDELARRE 2654
Query: 355 -IQKAIQEQRKISQETVKA 372
++ +Q + I+ +KA
Sbjct: 2655 DVRHYLQGRSSIAGLLLKA 2673
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/310 (21%), Positives = 131/310 (42%), Gaps = 59/310 (19%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLE---KGFLKEKEQEAISFQDRYKELQEKHKQE 198
E++L+ E E++ + +VE + LE + E + + SF ++ +L+ ++E
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---- 254
+ + EA E +A Q+ ++ E E++ +E+ K E L +
Sbjct: 1568 HVAVAQLREEA------ERRAQQQAEAERAREEAERE----LERWQLKANEALRLRLQAE 1617
Query: 255 ---HQRLLEMLDTEKELLKEKIKEA-----LIQQSQEQKEILEKCLEEERQRNKEALVSA 306
Q+ L + EK+ +E +EA +Q+ Q+E+ E+ LE++RQ +
Sbjct: 1618 EVAQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 307 AKLEKEAVK--------DAVLKVVEEERKNLEK---AHAEERELWKTEHAK--------- 346
E+E ++ + +++EEE L++ A ++R+ + E AK
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1736
Query: 347 ------------DQEKVSQEIQKAIQEQRKISQETVK-AAIIEEQKRSEKAVEEAVKRTR 393
EK Q ++ R++++E + A+ EE KR + EE R R
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1796
Query: 394 DELIEYIKEQ 403
E + E+
Sbjct: 1797 AEAERVLAEK 1806
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/222 (21%), Positives = 107/222 (48%), Gaps = 37/222 (16%)
Query: 193 EKHKQELEDMRKAGHEALSIIVD------EYKALLQS--------SVKQQVEAIEKQYIS 238
E+H +++E+ ++ + ++ I D YKA L+ V+ E++ ++Y+
Sbjct: 1227 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV- 1285
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI--LEKCLEEER 296
+ + H E L + ++ + ++E+ + A Q+++E++ + +E LE++R
Sbjct: 1286 --DLRTHYSE--LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1341
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
Q + + A+ E+EA K L++ +E + + E A D ++ + IQ
Sbjct: 1342 QLAEAHAQAKAQAEREA-------------KELQQ-RMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 357 KAIQEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDEL 396
+ +Q+ R+ S+ + KA E +RS +EE ++ R +L
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Score = 39.7 bits (91), Expect = 0.006
Identities = 82/394 (20%), Positives = 174/394 (44%), Gaps = 49/394 (12%)
Query: 60 GCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALV 119
G ++ ++ + E V T+P+ + ++ SL L E T +
Sbjct: 1065 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-------SLKKLRAQAEAQQPTFDAL 1117
Query: 120 DDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN-VLEKGFLKEKE 178
D E GA +LQQ+ ++ E +R ++ V L+E+ VL + ++++E
Sbjct: 1118 RD-ELRGAQEVGERLQQRHGERDV-------EVERWRERVAQLLERWQAVLAQTDVRQRE 1169
Query: 179 QEAISFQDRY-KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
E + Q RY +E + L+D R+ + ++ + + +A V++Q+ E+ +
Sbjct: 1170 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-----VREQLRQ-EQALL 1223
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL---EKCLEE 294
IE+ K EE Q + + D E +L+ K + + ++ ++ E ++E
Sbjct: 1224 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1283
Query: 295 --ERQRNKEALVSAAKLEKEAVKDAVLKVVEEER----------KNL---EKAHAEEREL 339
+ + + L + + + + + ++ EEER + L E A ++R+L
Sbjct: 1284 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 340 WKTE-HAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI 397
+ AK Q E+ ++E+Q+ +QE+ + + A ++QKRS ++E +++ R
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEE--VVRREEAAVDAQQQKRS---IQEELQQLRQSSE 1398
Query: 398 EYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
I+ + R + +RS +E + + QL A
Sbjct: 1399 AEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEA 1431
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/370 (21%), Positives = 166/370 (44%), Gaps = 43/370 (11%)
Query: 110 EKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVL 169
E N + L D + ++++ +L V+ +E R++Q E + + L
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 170 EKGFLKEKEQ----------EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKA 219
+ LKEK Q EA Q + KEL ++ + L++ ++ + L+ ++
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQLAEETQGFQR 2503
Query: 220 LLQSSVKQQVEA--------IEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE 271
L++ ++Q+E + +S + +A + + Q + + E L + +E
Sbjct: 2504 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Query: 272 KIK-----EALIQQSQEQKEILEKCLEEERQRNKEALVSAAKL---EKEAVKDAVLKVVE 323
K+ E QQS E L + + E +R KE L AKL + E ++ + +
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAE-LEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Query: 324 EERKNLEKAHAEERE-LWKTEHAKDQEKVS------QEIQKAIQ-------EQRKISQET 369
+E + L+++ E++ L + E +QEK E+ KA Q +Q+++ QE
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER 2682
Query: 370 VK-AAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQ 428
+ A +EE +R + EE V+R ++EL + +++++ ++++ + + E ++
Sbjct: 2683 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Query: 429 LSALIATEPV 438
+AL +E V
Sbjct: 2743 RAALAHSEEV 2752
Score = 64.3 bits (155), Expect = 2e-10
Identities = 65/313 (20%), Positives = 147/313 (46%), Gaps = 40/313 (12%)
Query: 135 QQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEK 194
Q ++ + + +EEE++R ++ E ++K E +EA + E E+
Sbjct: 2101 QAELEAARQRQLAAEEERRR--REAEERVQKSLAAE--------EEAARQRKAALEEVER 2150
Query: 195 HKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ 254
K ++E+ R+ A + + L Q + +++++A EK + A++++ + ++ L Q
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ-Q 2208
Query: 255 HQRLLEMLDTEKELLK---EKIKEALIQQSQE---------QKEILEKCLEEERQRNKEA 302
Q +L+ L E E + E+ +EA +Q +E + E L++ EE+ Q +A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 303 LVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQ 362
+A KL KEA ++A + E+ +K A+ + EK + ++ ++++
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD----------AEMEKHKKFAEQTLRQK 2318
Query: 363 RKISQE-TVKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQV-----IRQRSLS 416
++ QE T +EE + ++E ++R + E E +++ ++++ ++ LS
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 417 SLELFLSCAQKQL 429
L+ + + L
Sbjct: 2379 KLKARIEAENRAL 2391
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/331 (22%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 123 EDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNV---LEKGFLKEKEQ 179
E A +L+ +++ + +++V K R +++ S EK E G +E +
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 180 EAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSS-VKQQVEAIEKQYIS 238
EA + +E + + + ED + EA ++ ++ A+ +++ +K + E K+ +
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 239 AIEK----------QAHKCEELLNAQHQ--------RLLEMLDTEKELLKEKIKEALIQQ 280
E+ Q + EE AQH+ +L + D+E E K +++ L Q+
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQA-AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 281 SQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELW 340
Q ++EIL E+ +A K E E + E+ ++ E+A E
Sbjct: 2058 RQVEEEILALKASFEK-------AAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-- 2108
Query: 341 KTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELIEYI 400
+ + A ++E+ +E ++ +Q+ A EE R KA E V+R + + +
Sbjct: 2109 QRQLAAEEERRRREAEERVQK---------SLAAEEEAARQRKAALEEVERLKAK----V 2155
Query: 401 KEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
+E +RL + Q S L+L AQK+L A
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Score = 55.8 bits (133), Expect = 7e-08
Identities = 56/307 (18%), Positives = 140/307 (45%), Gaps = 17/307 (5%)
Query: 134 LQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQ- 192
L+ + E + + ++EE +R+++ V+ ++ E + EA + +++ + LQ
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 193 -EKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELL 251
E+ + + E+ + +A + + L+++ + ++ + S EK A + E L
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSL 1733
Query: 252 NAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQK--EILEKCLEEERQRNKEALVSAAKL 309
+H + + L+E+ + QQ++ ++ E E+ LE + + EAL +
Sbjct: 1734 QEEHVAVAQ--------LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 310 EKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQET 369
E+ A + ++ + E++K + A R + + + +E QE++K QR++++ T
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1841
Query: 370 VKAAIIEEQKRSEKAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQL 429
+ + EQ+ E + +L+E + + + + LE L+ + ++
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901
Query: 430 SALIATE 436
L+A++
Sbjct: 1902 EVLLASK 1908
Score = 51.6 bits (122), Expect = 1e-06
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 13/289 (4%)
Query: 151 EKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL 210
E R+K + E +++ + + E EA + R +E +HK ++E+ +A
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 211 SIIVDEYKALLQSSVKQ--QVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKEL 268
++ K L++ +++Q QVE ++ EK A EL + DT +
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099
Query: 269 LKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAV-LKV-VEEER 326
+ +++ A +Q ++E + EE Q++ A AA+ K A+++ LK VEE R
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159
Query: 327 KNLEKAHAEE-RELWKTEHAKDQEKVSQEIQKAI---QEQRKISQETVKAAIIEEQKRSE 382
+ E+A E R+L + A + ++E A Q+++++ Q + + +Q R E
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219
Query: 383 KAVEEAVKRTRDELIEYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
EA +R +E E + Q + +R + E A++Q A
Sbjct: 2220 ---AEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/259 (24%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 133 QLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEK----------EQEAI 182
+LQQ+ L++K EE Q ++Q E L+++ L++ FL EK EQE
Sbjct: 2598 KLQQEAKLLQLK----SEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 183 S----FQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYIS 238
FQD + Q+ +++ ++ E ++ +A + ++ +++ +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQR 298
+E+Q + EELL ++QRL E L +LL+E+ + AL E+ + +
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQL----QLLEEQHRAALAH--SEEVTASQVAATKTLPN 2765
Query: 299 NKEALVS-AAKLEKEAVKDAVLKVVEEERKNLEKA---HAEERELWKTEHAKDQEKVSQE 354
++AL AA+ E E D + + V +R L++A AEE + H E +E
Sbjct: 2766 GRDALDGPAAEAEPEHSFDGLRRKVSAQR--LQEAGILSAEELQRLAQGHTTVDELARRE 2823
Query: 355 -IQKAIQEQRKISQETVKA 372
++ +Q + I+ +KA
Sbjct: 2824 DVRHYLQGRSSIAGLLLKA 2842
Score = 46.6 bits (109), Expect = 5e-05
Identities = 66/310 (21%), Positives = 131/310 (42%), Gaps = 59/310 (19%)
Query: 142 EIKLKVSEEEKQRIKQDVESLMEKHNVLE---KGFLKEKEQEAISFQDRYKELQEKHKQE 198
E++L+ E E++ + +VE + LE + E + + SF ++ +L+ ++E
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736
Query: 199 LEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQ---- 254
+ + EA E +A Q+ ++ E E++ +E+ K E L +
Sbjct: 1737 HVAVAQLREEA------ERRAQQQAEAERAREEAERE----LERWQLKANEALRLRLQAE 1786
Query: 255 ---HQRLLEMLDTEKELLKEKIKEA-----LIQQSQEQKEILEKCLEEERQRNKEALVSA 306
Q+ L + EK+ +E +EA +Q+ Q+E+ E+ LE++RQ +
Sbjct: 1787 EVAQQKSLAQAEAEKQK-EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 307 AKLEKEAVK--------DAVLKVVEEERKNLEK---AHAEERELWKTEHAK--------- 346
E+E ++ + +++EEE L++ A ++R+ + E AK
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1905
Query: 347 ------------DQEKVSQEIQKAIQEQRKISQETVK-AAIIEEQKRSEKAVEEAVKRTR 393
EK Q ++ R++++E + A+ EE KR + EE R R
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR 1965
Query: 394 DELIEYIKEQ 403
E + E+
Sbjct: 1966 AEAERVLAEK 1975
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/222 (21%), Positives = 107/222 (48%), Gaps = 37/222 (16%)
Query: 193 EKHKQELEDMRKAGHEALSIIVD------EYKALLQS--------SVKQQVEAIEKQYIS 238
E+H +++E+ ++ + ++ I D YKA L+ V+ E++ ++Y+
Sbjct: 1396 ERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV- 1454
Query: 239 AIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEI--LEKCLEEER 296
+ + H E L + ++ + ++E+ + A Q+++E++ + +E LE++R
Sbjct: 1455 --DLRTHYSE--LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1510
Query: 297 QRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQ 356
Q + + A+ E+EA K L++ +E + + E A D ++ + IQ
Sbjct: 1511 QLAEAHAQAKAQAEREA-------------KELQQ-RMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 357 KAIQEQRKISQETV--KAAIIEEQKRSEKAVEEAVKRTRDEL 396
+ +Q+ R+ S+ + KA E +RS +EE ++ R +L
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Score = 39.7 bits (91), Expect = 0.006
Identities = 82/394 (20%), Positives = 174/394 (44%), Gaps = 49/394 (12%)
Query: 60 GCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALV 119
G ++ ++ + E V T+P+ + ++ SL L E T +
Sbjct: 1234 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-------SLKKLRAQAEAQQPTFDAL 1286
Query: 120 DDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHN-VLEKGFLKEKE 178
D E GA +LQQ+ ++ E +R ++ V L+E+ VL + ++++E
Sbjct: 1287 RD-ELRGAQEVGERLQQRHGERDV-------EVERWRERVAQLLERWQAVLAQTDVRQRE 1338
Query: 179 QEAISFQDRY-KELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYI 237
E + Q RY +E + L+D R+ + ++ + + +A V++Q+ E+ +
Sbjct: 1339 LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA-----VREQLRQ-EQALL 1392
Query: 238 SAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEIL---EKCLEE 294
IE+ K EE Q + + D E +L+ K + + ++ ++ E ++E
Sbjct: 1393 EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQE 1452
Query: 295 --ERQRNKEALVSAAKLEKEAVKDAVLKVVEEER----------KNL---EKAHAEEREL 339
+ + + L + + + + + ++ EEER + L E A ++R+L
Sbjct: 1453 YVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 340 WKTE-HAKDQ-EKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI 397
+ AK Q E+ ++E+Q+ +QE+ + + A ++QKRS ++E +++ R
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEE--VVRREEAAVDAQQQKRS---IQEELQQLRQSSE 1567
Query: 398 EYIKEQKRLDQVIRQRSLSSLELFLSCAQKQLSA 431
I+ + R + +RS +E + + QL A
Sbjct: 1568 AEIQAKARQAEA-AERSRLRIEEEIRVVRLQLEA 1600
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,387,309
Number of Sequences: 37866
Number of extensions: 727657
Number of successful extensions: 14304
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 420
Number of HSP's successfully gapped in prelim test: 1259
Number of HSP's that attempted gapping in prelim test: 5172
Number of HSP's gapped (non-prelim): 5137
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.