Search of human proteins with 7019383

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
         (649 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...  1315   0.0  
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...  1315   0.0  
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...   740   0.0  
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...   582   e-166
gi|45505137 podocan [Homo sapiens]                                    131   2e-30
gi|51317373 netrin-G1 ligand [Homo sapiens]                           128   1e-29
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]         125   1e-28
gi|19743846 decorin isoform a preproprotein [Homo sapiens]            125   2e-28
gi|4503271 decorin isoform a preproprotein [Homo sapiens]             125   2e-28
gi|41350214 asporin [Homo sapiens]                                    125   2e-28
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]           124   4e-28
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]                  122   8e-28
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]                  122   8e-28
gi|71040111 fibromodulin precursor [Homo sapiens]                     122   8e-28
gi|4826876 osteomodulin [Homo sapiens]                                122   1e-27
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...   119   1e-26
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...   119   1e-26
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...   116   6e-26
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]   115   1e-25
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   112   1e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   112   1e-24
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]    109   9e-24
gi|88702793 slit-like 2 [Homo sapiens]                                108   1e-23
gi|198041768 synleurin [Homo sapiens]                                 108   2e-23
gi|4502403 biglycan preproprotein [Homo sapiens]                      106   6e-23
gi|194440719 chondroadherin-like [Homo sapiens]                       106   8e-23
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   105   2e-22
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...   104   2e-22
gi|5901992 keratocan [Homo sapiens]                                   104   2e-22
gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]                  104   3e-22

>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 1315 bits (3403), Expect = 0.0
 Identities = 649/649 (100%), Positives = 649/649 (100%)

Query: 1   MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA 60
           MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA
Sbjct: 1   MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA 60

Query: 61  TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
           TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT
Sbjct: 61  TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
           YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
           RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240

Query: 241 PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300
           PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL
Sbjct: 241 PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300

Query: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI 360
           ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI
Sbjct: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI 360

Query: 361 VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS 420
           VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS
Sbjct: 361 VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS 420

Query: 421 DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV 480
           DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV
Sbjct: 421 DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV 480

Query: 481 PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV 540
           PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV
Sbjct: 481 PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV 540

Query: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600
           TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS
Sbjct: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600

Query: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649
           NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS
Sbjct: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 1315 bits (3403), Expect = 0.0
 Identities = 649/649 (100%), Positives = 649/649 (100%)

Query: 1   MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA 60
           MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA
Sbjct: 1   MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDA 60

Query: 61  TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
           TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT
Sbjct: 61  TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
           YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
           RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240

Query: 241 PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300
           PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL
Sbjct: 241 PVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300

Query: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI 360
           ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI
Sbjct: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGI 360

Query: 361 VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS 420
           VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS
Sbjct: 361 VSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTS 420

Query: 421 DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV 480
           DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV
Sbjct: 421 DTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMV 480

Query: 481 PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV 540
           PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV
Sbjct: 481 PMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALV 540

Query: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600
           TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS
Sbjct: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600

Query: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649
           NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS
Sbjct: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score =  740 bits (1911), Expect = 0.0
 Identities = 377/627 (60%), Positives = 466/627 (74%), Gaps = 12/627 (1%)

Query: 30  SCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIY 89
           +CPSVCRCD GFIYCNDR LTSIP  IP+DATTLYLQNNQINNAGIP DLK  + V+ IY
Sbjct: 53  TCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIY 112

Query: 90  LYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGA 149
           LY N LDEFP NLP+ ++ELHLQ+NN+RTI  DSL++IP LE+LHLDDNSVS VSIEE A
Sbjct: 113 LYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDA 172

Query: 150 FRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGN 209
           F DS  L+LLFLSRNHLS+IP GLP T+EELRLDDNRISTI   + +GL SL+RLVLDGN
Sbjct: 173 FADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGN 232

Query: 210 LLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSY 269
           LL N  + D  F  L NLTELSLVRNSL A P+NLP  +L+KLYLQDN I+ +P N  + 
Sbjct: 233 LLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAK 292

Query: 270 LRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNV 329
           +R+L RLD+SNNNL+ LP+G+FDDL N+ QL+LRNNPW+CGC + W+RDW+++    VNV
Sbjct: 293 MRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNV 352

Query: 330 RGLMCQAPEKVRGMAIKDLNAELFDCKDS----GIVSTIQITTAIPN-TVYPAQGQWPAP 384
           RGLMCQ PEKVRGMAIKD+ +E+ +C ++    G+ +    TTA  + +    QG     
Sbjct: 353 RGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTL 412

Query: 385 VTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLG 444
             K+P ++ P    D+        KT+ I VK++T+D+I I+WK  LP ++ RLSWL+LG
Sbjct: 413 KAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLG 472

Query: 445 HSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVCIETETAPL 504
           HSPA GSITET+V G+++EYL+TALEP S Y +CMV METSN Y+ DETPVC + ETA  
Sbjct: 473 HSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETAD- 531

Query: 505 RMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIAL-LALVCWYVHRNGSLFSRNC 563
             Y PTTTLN+EQ   P    +LPLA IIGGAVALV + L L  +CWYVH+ G L +R  
Sbjct: 532 -SYGPTTTLNQEQNAGPM--ASLPLAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRER 588

Query: 564 AYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLY 623
           AY++G R+KDDY E+GTKKDNSILEIR    QMLPI N   +KEE+V+HTIFP NG +L 
Sbjct: 589 AYNRGSRKKDDYMESGTKKDNSILEIRGPGLQMLPI-NPYRAKEEYVVHTIFPSNGSSLC 647

Query: 624 KNNHSES-SSNRSYRDSGIPDSDHSHS 649
           K  H+    + R YRD GIPD D+S++
Sbjct: 648 KATHTIGYGTTRGYRDGGIPDIDYSYT 674


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score =  582 bits (1499), Expect = e-166
 Identities = 303/649 (46%), Positives = 423/649 (65%), Gaps = 26/649 (4%)

Query: 15  IGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
           +GL+ QV+ L     +CPSVCRCD  F+YCN+R LTS+P GIPE  T LYL NNQINNAG
Sbjct: 24  LGLYSQVSKLL----ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAG 79

Query: 75  IPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELH 134
            P++L N+  V  +YLY N LDEFP NLPK V+ LHLQENNI+TI+  +L+++  LEELH
Sbjct: 80  FPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELH 139

Query: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194
           LDDNS+S V +E+GAFR++  L+LLFLS+NHLS++P GLP  ++ELR+D+NRI+ IS  +
Sbjct: 140 LDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMA 199

Query: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYL 254
            Q LTSL+RL++DGNLL N G+ +  F +L  L E S+VRNSL+  P +LPGT+L +LYL
Sbjct: 200 FQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYL 259

Query: 255 QDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314
           QDN IN +P  AFS LR+L RLD+SNN L  L QG+FD+L N+ QL  RNNPW+C C +K
Sbjct: 260 QDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319

Query: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKD--------SGIVSTIQI 366
           WV +WL+ +P  +NVRG MCQ PE+VRGMA+++LN  L  C          +   ST   
Sbjct: 320 WVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASP 379

Query: 367 TTAIPNTVYPAQGQW---PAPVT-KQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDT 422
           TT  P    P   +    P P T K P I +       +    P  + I +++  V   +
Sbjct: 380 TTQPPTLSIPNPSRSYTPPTPTTSKLPTIPD---WDGRERVTPPISERIQLSIHFVNDTS 436

Query: 423 IHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPM 482
           I +SW     + A +L+W+K+GHS   G + E IV+GE+    +  LEP S Y++C+VP+
Sbjct: 437 IQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPL 496

Query: 483 ETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYK--NPNLPLAAIIGGAVALV 540
           +  N    ++T +C E  T    + N + T +  ++   +   +P L LA +IGGAV  V
Sbjct: 497 DAFNYRAVEDT-ICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFL-LAGLIGGAVIFV 554

Query: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600
            + LL++ CW++H+ G   S+   Y++G RRKDDY EAGTKKDNSILE+ ETSFQ++ ++
Sbjct: 555 LVVLLSVFCWHMHKKGRYTSQKWKYNRG-RRKDDYCEAGTKKDNSILEMTETSFQIVSLN 613

Query: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649
           N+ + K +F +  I+ PNG   Y + H    +N  Y +S +PD +H H+
Sbjct: 614 NDQLLKGDFRLQPIYTPNGGINYTDCH--IPNNMRYCNSSVPDLEHCHT 660


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score =  131 bits (330), Expect = 2e-30
 Identities = 77/223 (34%), Positives = 122/223 (54%), Gaps = 2/223 (0%)

Query: 63  LYLQNNQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
           L L +NQ+   GI P   + L ++  ++LY+N+L+  P+ LP+ V+ L +  N I  I  
Sbjct: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
           +  +   +LEEL+L  N +++  +   AFR    LR L LS N L T+P GLPR +  L+
Sbjct: 446 EDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505

Query: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
           +  N ++ ++  +L G+  L+ L L  N L +  LG + + +L +L  L +  N LT  P
Sbjct: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565

Query: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
             LP  +L  LYLQ+N I+ VP NAF     L  + +  N L+
Sbjct: 566 EGLP-ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA 607



 Score =  111 bits (278), Expect = 2e-24
 Identities = 87/308 (28%), Positives = 138/308 (44%), Gaps = 33/308 (10%)

Query: 28  AKSCPSVCRCDA-GFIYCNDRFLTSIPTGIPEDAT------------------------T 62
           A SCP  C C   G + C    L   P  +PE                           T
Sbjct: 113 AVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLET 172

Query: 63  LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
           L LQNN++ + G+P    ++L  +  +YL +N L   P  LP  +  +    N +  I  
Sbjct: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
            +  + P L  ++L +N ++   + +  F  S+ + +L LS N L  +P  LP  + +L 
Sbjct: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292

Query: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
           L +N++  I   +   L+SL+ L L  N L + GL ++ F+ L +L  L L  N+L+  P
Sbjct: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352

Query: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGI----FDDLDNI 297
             LP  +L  L+L+ N I  V  N  + +R L  L + +N L    QGI    F  L  +
Sbjct: 353 AGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE--QGIHPLAFQGLKRL 409

Query: 298 TQLILRNN 305
             + L NN
Sbjct: 410 HTVHLYNN 417



 Score =  110 bits (274), Expect = 5e-24
 Identities = 79/256 (30%), Positives = 123/256 (48%), Gaps = 28/256 (10%)

Query: 62  TLYLQNNQINNAGIPSDLKN-LLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
           ++YL NN++ +AG+P ++ N    VE + L  N L   P +LP  + +LHL+ N +  I 
Sbjct: 243 SVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIP 302

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
             + S++  L EL+L +N ++   ++   F   + L  L LS N+LS +P GLPR++  L
Sbjct: 303 PGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL 362

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
            L+ N I ++ +  L  + SL+ L+L  N L   G+    F  L  L  + L  N+L   
Sbjct: 363 HLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV 422

Query: 241 PVNLPGTNLRKLYLQDNHIN--------------------------RVPPNAFSYLRQLY 274
           P  LP   +R L +  N I                           +V  +AF  LR L 
Sbjct: 423 PSGLP-RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLR 481

Query: 275 RLDMSNNNLSNLPQGI 290
            LD+S N L  LP G+
Sbjct: 482 SLDLSGNRLHTLPPGL 497



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 83/293 (28%), Positives = 130/293 (44%), Gaps = 32/293 (10%)

Query: 42  IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
           ++  +  L  IP G   + ++L   YLQNN + + G+ ++    L  +E + L  N+L  
Sbjct: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350

Query: 98  FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
            P  LP+ +  LHL++N IR++  + L+ I  LE L L  N +    I   AF+    L 
Sbjct: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410

Query: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
            + L  N L  +P GLPR +  L +  N+I+ I          L+ L L  N + +  + 
Sbjct: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470

Query: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPG-----------------------TNLRKLYL 254
              F  L  L  L L  N L   P  LP                          LR+LYL
Sbjct: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530

Query: 255 QDNHI--NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
             N +    + P A+  L  L  LD++ N L+ +P+G+ + L+    L L+NN
Sbjct: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLE---YLYLQNN 580



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 25/219 (11%)

Query: 42  IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG------------------------IPS 77
           ++  +  L  +P+G+P    TL + +NQI   G                        +  
Sbjct: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471

Query: 78  DLKNLLKVER-IYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLD 136
           D    L++ R + L  N L   P  LP+ V  L ++ N +  +   +L  +  L EL+L 
Sbjct: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531

Query: 137 DNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQ 196
            N + + ++   A+ D  +L+LL ++ N L+ IP GLP ++E L L +N+IS + + +  
Sbjct: 532 SNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFD 591

Query: 197 GLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRN 235
              +LK + L  N L    + D  F  L +L  L +  N
Sbjct: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score =  128 bits (322), Expect = 1e-29
 Identities = 106/355 (29%), Positives = 169/355 (47%), Gaps = 38/355 (10%)

Query: 10  LIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGF--IYCNDRFLTSIPTGIPEDATTLYLQN 67
           L+   + L L V    V A++CPSVC C   F  + C  + L  +P GI  +   L L  
Sbjct: 26  LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHE 85

Query: 68  NQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKI 127
           NQI           ++KV       NS         ++++ L L  N+IRTI   + + +
Sbjct: 86  NQIQ----------IIKV-------NSFKHL-----RHLEILQLSRNHIRTIEIGAFNGL 123

Query: 128 PYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD--- 184
             L  L L DN ++  +I  GAF   + L+ L+L  N + +IP      I  LR  D   
Sbjct: 124 ANLNTLELFDNRLT--TIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181

Query: 185 -NRISTISSPSLQGLTSLKRLVLDG-NLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA-P 241
             R+S IS  + +GL++L+ L L   NL     L       L+ L EL L  N L+A  P
Sbjct: 182 LKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTP-----LIKLDELDLSGNHLSAIRP 236

Query: 242 VNLPGT-NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300
            +  G  +L+KL++  + I  +  NAF  L+ L  +++++NNL+ LP  +F  L ++ ++
Sbjct: 237 GSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERI 296

Query: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC 355
            L +NPW C C + W+  W++ +          C  P  ++G  I +L+   F C
Sbjct: 297 HLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score =  125 bits (314), Expect = 1e-28
 Identities = 95/300 (31%), Positives = 140/300 (46%), Gaps = 32/300 (10%)

Query: 84  KVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAV 143
           +  R+      L E P ++P   + L+LQEN I+ I  D+   + +LE L L  N V   
Sbjct: 66  QASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVR-- 123

Query: 144 SIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR---LDDNRISTISSPSLQGLTS 200
            IE GAF     L  L L  N L+T+P      + +LR   L +N I +I S +   + S
Sbjct: 124 KIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPS 183

Query: 201 LKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL---------------- 244
           L+RL L G L     + +  F  LVNL  L+L   +L   P NL                
Sbjct: 184 LRRLDL-GELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP-NLTALVRLEELELSGNRL 241

Query: 245 ----PG-----TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLD 295
               PG     T+LRKL+L    +  +  NAF  L+ L  L++S+NNL +LP  +F  L 
Sbjct: 242 DLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLH 301

Query: 296 NITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC 355
            + ++ L +NPW+C C + W+  WL+            C AP  ++G  I +L+   F C
Sbjct: 302 RLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC 361


>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score =  125 bits (313), Expect = 2e-28
 Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)

Query: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82
           CP  C+C    + C+D  L  +P  +P D T L LQNN+I     G   +LKNL      
Sbjct: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113

Query: 83  ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124
                          +K+ER+YL  N L E P  +PK ++EL   EN I   R +T++ L
Sbjct: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173

Query: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
           +++  +E   L  N + +  IE GAF+    L  + ++  ++++IP GLP ++ EL LD 
Sbjct: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230

Query: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244
           N+IS + + SL+GL +L +L L  N ++   + +    N  +L EL L  N LT  P  L
Sbjct: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288

Query: 245 PGTN-LRKLYLQDNHINRVPPNAF 267
                ++ +YL +N+I+ V  + F
Sbjct: 289 AEHKYIQVVYLHNNNISVVGSSDF 312



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 67/235 (28%), Positives = 107/235 (45%), Gaps = 28/235 (11%)

Query: 95  LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
           LD+ P +LP     L LQ N I  I       +  L  L L +N +S VS   GAF    
Sbjct: 72  LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129

Query: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
            L  L+LS+N L  +P  +P+T++ELR  +N I+ +   +  GL  +  + L  N L + 
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189

Query: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLY 274
           G+ +  F  +  L+ + +   ++T+ P  LP  +L +L+L  N I+RV   +   L  L 
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLP-PSLTELHLDGNKISRVDAASLKGLNNLA 248

Query: 275 RLDMS------------------------NNNLSNLPQGIFDDLDNITQLILRNN 305
           +L +S                        NN L+ +P G+ +    I  + L NN
Sbjct: 249 KLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNN 302


>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score =  125 bits (313), Expect = 2e-28
 Identities = 86/264 (32%), Positives = 136/264 (51%), Gaps = 32/264 (12%)

Query: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNA--GIPSDLKNL------ 82
           CP  C+C    + C+D  L  +P  +P D T L LQNN+I     G   +LKNL      
Sbjct: 54  CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILV 113

Query: 83  ---------------LKVERIYLYHNSLDEFPTNLPKYVKELHLQENNI---RTITYDSL 124
                          +K+ER+YL  N L E P  +PK ++EL   EN I   R +T++ L
Sbjct: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173

Query: 125 SKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
           +++  +E   L  N + +  IE GAF+    L  + ++  ++++IP GLP ++ EL LD 
Sbjct: 174 NQMIVIE---LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDG 230

Query: 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL 244
           N+IS + + SL+GL +L +L L  N ++   + +    N  +L EL L  N LT  P  L
Sbjct: 231 NKISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGL 288

Query: 245 PGTN-LRKLYLQDNHINRVPPNAF 267
                ++ +YL +N+I+ V  + F
Sbjct: 289 AEHKYIQVVYLHNNNISVVGSSDF 312



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 67/235 (28%), Positives = 107/235 (45%), Gaps = 28/235 (11%)

Query: 95  LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
           LD+ P +LP     L LQ N I  I       +  L  L L +N +S VS   GAF    
Sbjct: 72  LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVS--PGAFTPLV 129

Query: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
            L  L+LS+N L  +P  +P+T++ELR  +N I+ +   +  GL  +  + L  N L + 
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189

Query: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLY 274
           G+ +  F  +  L+ + +   ++T+ P  LP  +L +L+L  N I+RV   +   L  L 
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLP-PSLTELHLDGNKISRVDAASLKGLNNLA 248

Query: 275 RLDMS------------------------NNNLSNLPQGIFDDLDNITQLILRNN 305
           +L +S                        NN L+ +P G+ +    I  + L NN
Sbjct: 249 KLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNN 302


>gi|41350214 asporin [Homo sapiens]
          Length = 380

 Score =  125 bits (313), Expect = 2e-28
 Identities = 86/261 (32%), Positives = 123/261 (47%), Gaps = 27/261 (10%)

Query: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQI-------------------N 71
           CP  C+C +  ++C+D  LTS+PT IP D   L LQNN+I                   N
Sbjct: 75  CPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILN 134

Query: 72  NAGI----PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKI 127
           N  +    P       K+ R+YL HN L E P NLPK + EL + EN ++ I  D+   +
Sbjct: 135 NNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGM 194

Query: 128 PYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRI 187
             L  L +  N +    IE GAF       +  ++   L+++P GLP T+ EL LD N+I
Sbjct: 195 NALHVLEMSANPLDNNGIEPGAFEGVTVFHIR-IAEAKLTSVPKGLPPTLLELHLDYNKI 253

Query: 188 STISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT 247
           ST+     +    L+RL L  N + +   G     N+  + E+ L  N L   P  LP  
Sbjct: 254 STVELEDFKRYKELQRLGLGNNKITDIENGS--LANIPRVREIHLENNKLKKIPSGLPEL 311

Query: 248 N-LRKLYLQDNHINRVPPNAF 267
             L+ ++L  N I RV  N F
Sbjct: 312 KYLQIIFLHSNSIARVGVNDF 332



 Score =  106 bits (265), Expect = 6e-23
 Identities = 66/211 (31%), Positives = 112/211 (53%), Gaps = 4/211 (1%)

Query: 95  LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
           L   PTN+P   + L LQ N I+ I  +    +  L  L L++N ++   I   AF  + 
Sbjct: 93  LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLT--KIHPKAFLTTK 150

Query: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
            LR L+LS N LS IP  LP+++ ELR+ +N++  I   + +G+ +L  L +  N L+N+
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210

Query: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLY 274
           G+ +   F  V +  + +    LT+ P  LP T L +L+L  N I+ V    F   ++L 
Sbjct: 211 GI-EPGAFEGVTVFHIRIAEAKLTSVPKGLPPT-LLELHLDYNKISTVELEDFKRYKELQ 268

Query: 275 RLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
           RL + NN ++++  G   ++  + ++ L NN
Sbjct: 269 RLGLGNNKITDIENGSLANIPRVREIHLENN 299


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score =  124 bits (310), Expect = 4e-28
 Identities = 142/558 (25%), Positives = 237/558 (42%), Gaps = 74/558 (13%)

Query: 22  APLSVMAKSCPSVCRCDAGF--IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDL 79
           A  S   ++CPSVC C   F  + C  R L+ +P GIP +   L L  N I         
Sbjct: 37  AAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNI--------- 87

Query: 80  KNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNS 139
             +++ +     H            +++ L L  N+IR I   + + +  L  L L DN 
Sbjct: 88  -QMIQADTFRHLH------------HLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNW 134

Query: 140 VSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLD---DNRISTISSPSL 195
           ++   I  GAF   + LR L+L  N + +IP +   R    +RLD     ++  IS  + 
Sbjct: 135 LTV--IPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAF 192

Query: 196 QGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG-----TNLR 250
           +GL +LK L L   + N   + +     LV L EL +  N     P   PG     ++L+
Sbjct: 193 EGLFNLKYLNL--GMCNIKDMPN--LTPLVGLEELEMSGNHF---PEIRPGSFHGLSSLK 245

Query: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310
           KL++ ++ ++ +  NAF  L  L  L++++NNLS+LP  +F  L  + +L L +NPW C 
Sbjct: 246 KLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCD 305

Query: 311 CKMKWVRDWLQS-LPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369
           C + W+  WL+  +P      G  C AP  +RG  + +++   F C    I+        
Sbjct: 306 CDILWLAWWLREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQCSAPFIMDA------ 358

Query: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKL 429
            P  +  ++G+      + P + + K    + T  S + +   I+V  +   T++ S  L
Sbjct: 359 -PRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISV--LNDGTLNFSHVL 415

Query: 430 ALPMTALRLSWLK--LGHSPAFGSITETIVTGERSEYL--------VTALEPDSPYKVCM 479
            L  T +    +    G+S A   +  +      S Y          T + P+   +   
Sbjct: 416 -LSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEISPEDTTRKYK 474

Query: 480 VPMETSNLY---LFDETPVCIETETAPLRMYNPTTTLNREQE---KEPYKNPNLPLAAII 533
               TS  Y       T V I+T   P ++  P T    + +    E  K   +    II
Sbjct: 475 PVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPATDTTDKMQTSLDEVMKTTKI----II 530

Query: 534 GGAVALVTIALLALVCWY 551
           G  VA+  +A   L+ +Y
Sbjct: 531 GCFVAVTLLAAAMLIVFY 548


>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
          Length = 510

 Score =  122 bits (307), Expect = 8e-28
 Identities = 86/256 (33%), Positives = 120/256 (46%), Gaps = 28/256 (10%)

Query: 62  TLYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
           ++YL NNQ++NAG+P D  +    +  + L +N L   P +LP  ++ LHLQ N I  + 
Sbjct: 171 SVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVP 230

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
             +LS+   L EL+L  N ++   ++   F   + L  L LS N L+T+P GLPRT+  L
Sbjct: 231 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 290

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
            L  NRI  + +  L G   L+ L+L  N L + GL       L  L  L L  N L   
Sbjct: 291 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 350

Query: 241 PVNLPGTNLRKLYLQDNHI--------------------------NRVPPNAFSYLRQLY 274
           P  LP   LR L L  NH+                           RV   AF  LR L 
Sbjct: 351 PPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR 409

Query: 275 RLDMSNNNLSNLPQGI 290
            LD++ N L+ LP G+
Sbjct: 410 SLDLAGNQLTRLPMGL 425



 Score =  113 bits (283), Expect = 5e-25
 Identities = 93/310 (30%), Positives = 135/310 (43%), Gaps = 29/310 (9%)

Query: 24  LSVMAKSCPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQ------------- 69
           L  + ++CP  C C     + C+   L   P  I   A  L LQNNQ             
Sbjct: 37  LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLS 96

Query: 70  -----------INNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIR 117
                      I++ G+P +  ++L +++ + + HN L   P  LP+ ++   L  N + 
Sbjct: 97  GLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVM 156

Query: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI 177
            I   +  + P L  ++L +N +S   +   AFR S  +  L LS N LS +P  LP ++
Sbjct: 157 EIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSL 216

Query: 178 EELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL 237
           E L L +N IS +   +L   T L+ L L  N L + GL    F  L +L  L L  N L
Sbjct: 217 ERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQL 276

Query: 238 TAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL--SNLPQGIFDDLD 295
           T  P  LP T L  L+L  N I +V        R L  L + +N L  S LP G    L 
Sbjct: 277 TTVPAGLPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 335

Query: 296 NITQLILRNN 305
            +  L L  N
Sbjct: 336 GLHTLHLYGN 345



 Score =  104 bits (260), Expect = 2e-22
 Identities = 76/246 (30%), Positives = 112/246 (45%), Gaps = 5/246 (2%)

Query: 42  IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
           ++  +  ++ +P G     T L   YLQ+NQ+ ++G+ +     L  +E + L HN L  
Sbjct: 219 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 278

Query: 98  FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
            P  LP+ +  LHL  N IR +    L     L  L L  N + +  +  GA R    L 
Sbjct: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338

Query: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
            L L  N L  +P  LPR +  L L  N ++ + +  L     L  L L  N L +  + 
Sbjct: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398

Query: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLD 277
            + F  L  L  L L  N LT  P+ LP T LR L LQ N +  + P   + L QL  L 
Sbjct: 399 HRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELS 457

Query: 278 MSNNNL 283
           +++N L
Sbjct: 458 LAHNRL 463



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 2/181 (1%)

Query: 63  LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
           L LQ+NQ+ ++G+P+  L+ L  +  ++LY N LD  P  LP+ ++ L L  N++  +  
Sbjct: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
             L   P L EL+L  N +++  +   AFR    LR L L+ N L+ +P GLP  +  L+
Sbjct: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433

Query: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL-TELSLVRNSLTAA 240
           L  N++  +    L GL  L+ L L  N L    +G   +  L  L     LV +++  A
Sbjct: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRA 493

Query: 241 P 241
           P
Sbjct: 494 P 494


>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
          Length = 512

 Score =  122 bits (307), Expect = 8e-28
 Identities = 86/256 (33%), Positives = 120/256 (46%), Gaps = 28/256 (10%)

Query: 62  TLYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
           ++YL NNQ++NAG+P D  +    +  + L +N L   P +LP  ++ LHLQ N I  + 
Sbjct: 173 SVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVP 232

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
             +LS+   L EL+L  N ++   ++   F   + L  L LS N L+T+P GLPRT+  L
Sbjct: 233 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 292

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
            L  NRI  + +  L G   L+ L+L  N L + GL       L  L  L L  N L   
Sbjct: 293 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 352

Query: 241 PVNLPGTNLRKLYLQDNHI--------------------------NRVPPNAFSYLRQLY 274
           P  LP   LR L L  NH+                           RV   AF  LR L 
Sbjct: 353 PPALP-RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALR 411

Query: 275 RLDMSNNNLSNLPQGI 290
            LD++ N L+ LP G+
Sbjct: 412 SLDLAGNQLTRLPMGL 427



 Score =  113 bits (283), Expect = 5e-25
 Identities = 93/310 (30%), Positives = 135/310 (43%), Gaps = 29/310 (9%)

Query: 24  LSVMAKSCPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQ------------- 69
           L  + ++CP  C C     + C+   L   P  I   A  L LQNNQ             
Sbjct: 39  LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLS 98

Query: 70  -----------INNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIR 117
                      I++ G+P +  ++L +++ + + HN L   P  LP+ ++   L  N + 
Sbjct: 99  GLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVM 158

Query: 118 TITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI 177
            I   +  + P L  ++L +N +S   +   AFR S  +  L LS N LS +P  LP ++
Sbjct: 159 EIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSL 218

Query: 178 EELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL 237
           E L L +N IS +   +L   T L+ L L  N L + GL    F  L +L  L L  N L
Sbjct: 219 ERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQL 278

Query: 238 TAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL--SNLPQGIFDDLD 295
           T  P  LP T L  L+L  N I +V        R L  L + +N L  S LP G    L 
Sbjct: 279 TTVPAGLPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLR 337

Query: 296 NITQLILRNN 305
            +  L L  N
Sbjct: 338 GLHTLHLYGN 347



 Score =  104 bits (260), Expect = 2e-22
 Identities = 76/246 (30%), Positives = 112/246 (45%), Gaps = 5/246 (2%)

Query: 42  IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
           ++  +  ++ +P G     T L   YLQ+NQ+ ++G+ +     L  +E + L HN L  
Sbjct: 221 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 280

Query: 98  FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
            P  LP+ +  LHL  N IR +    L     L  L L  N + +  +  GA R    L 
Sbjct: 281 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 340

Query: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
            L L  N L  +P  LPR +  L L  N ++ + +  L     L  L L  N L +  + 
Sbjct: 341 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 400

Query: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLD 277
            + F  L  L  L L  N LT  P+ LP T LR L LQ N +  + P   + L QL  L 
Sbjct: 401 HRAFRRLRALRSLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELS 459

Query: 278 MSNNNL 283
           +++N L
Sbjct: 460 LAHNRL 465



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 2/181 (1%)

Query: 63  LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
           L LQ+NQ+ ++G+P+  L+ L  +  ++LY N LD  P  LP+ ++ L L  N++  +  
Sbjct: 316 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 375

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
             L   P L EL+L  N +++  +   AFR    LR L L+ N L+ +P GLP  +  L+
Sbjct: 376 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 435

Query: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL-TELSLVRNSLTAA 240
           L  N++  +    L GL  L+ L L  N L    +G   +  L  L     LV +++  A
Sbjct: 436 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRA 495

Query: 241 P 241
           P
Sbjct: 496 P 496


>gi|71040111 fibromodulin precursor [Homo sapiens]
          Length = 376

 Score =  122 bits (307), Expect = 8e-28
 Identities = 98/296 (33%), Positives = 135/296 (45%), Gaps = 45/296 (15%)

Query: 29  KSCPSVCRCDAGF---IYCNDRFLTSIPTGIPEDATTLYLQNNQI---------NNAG-- 74
           + CP  C C   F   +YC++R L  +P  +P     +Y QNNQI         N  G  
Sbjct: 74  RDCPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQITSIQEGVFDNATGLL 132

Query: 75  --------IPSD------LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
                   I SD         L  +ER+YL HN+L   P  LP+ ++ELHL  N I  + 
Sbjct: 133 WIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVP 192

Query: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
            ++L  +  L  L+L  N +  V     + R    L LL LS NHL  +P GLP  +E+L
Sbjct: 193 NNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQL 249

Query: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL-TA 239
            ++ N + T+     +G   L  + L  N L N+GL     FN  +L EL L  N L   
Sbjct: 250 YMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNT-FNSSSLLELDLSYNQLQKI 308

Query: 240 APVNLPGTNLRKLYLQDNHINRVPPNAFSYL--------RQLYRLDMSNNNLSNLP 287
            PVN   TNL  LYLQ N IN    ++F  +         Q+ RLD +    S +P
Sbjct: 309 PPVN---TNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIKRSAMP 361



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 58/200 (29%), Positives = 100/200 (50%), Gaps = 6/200 (3%)

Query: 102 LPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFL 161
           +P  +K ++ Q N I +I          L  + L  N +++  +    F    +L  L+L
Sbjct: 103 VPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYL 162

Query: 162 SRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVF 221
             N+L+ +P  LPR++ EL LD N+IS + + +L+GL +L  L L  N +   G   +  
Sbjct: 163 DHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGSSMR-- 220

Query: 222 FNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281
             L +L  L L  N L   P  LP   L +LY++ N++  VP + F    +L  + +S+N
Sbjct: 221 -GLRSLILLDLSYNHLRKVPDGLPSA-LEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHN 278

Query: 282 NLSNLPQGIFDDLDNITQLI 301
           +L+N   G+  +  N + L+
Sbjct: 279 SLTN--NGLASNTFNSSSLL 296


>gi|4826876 osteomodulin [Homo sapiens]
          Length = 421

 Score =  122 bits (306), Expect = 1e-27
 Identities = 81/258 (31%), Positives = 134/258 (51%), Gaps = 12/258 (4%)

Query: 48  FLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVK 107
           F  ++  G+P    TL   +        PS +         Y  +  L   P N+P +++
Sbjct: 45  FRQNVDYGVPFHQYTLGCVSECFCPTNFPSSM---------YCDNRKLKTIP-NIPMHIQ 94

Query: 108 ELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLS 167
           +L+LQ N I  +T +S     +L+E++L  N + +  I+ G F     L  L L  N+L 
Sbjct: 95  QLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLE 154

Query: 168 TIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL 227
             P+ LP+++E L L  N IS + + ++ GL +L  L L  N L++  L DK+F  +  L
Sbjct: 155 EFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKL 214

Query: 228 TELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLP 287
            +L+L  N L + P  LP ++L  L L++N I+ +P   F  L +L+ L MS+N L ++P
Sbjct: 215 MQLNLCSNRLESMPPGLP-SSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIP 273

Query: 288 QGIFDDLDNITQLILRNN 305
             IF +L NI +L + +N
Sbjct: 274 YNIF-NLPNIVELSVGHN 290



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 83/271 (30%), Positives = 122/271 (45%), Gaps = 40/271 (14%)

Query: 23  PLSVMAKSCPSVCRCDAGF---IYCNDRFLTSIPTGIPEDATTLYLQNNQIN-------- 71
           P       C S C C   F   +YC++R L +IP  IP     LYLQ N+I         
Sbjct: 54  PFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIPN-IPMHIQQLYLQFNEIEAVTANSFI 112

Query: 72  --------------------NAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHL 111
                               + G+ + L NLL+   ++L HN+L+EFP  LPK ++ L L
Sbjct: 113 NATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQ---LHLEHNNLEEFPFPLPKSLERLLL 169

Query: 112 QENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPW 171
             N I  +  +++  +  L  L L  N +    +++  F     L  L L  N L ++P 
Sbjct: 170 GYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPP 229

Query: 172 GLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELS 231
           GLP ++  L L++N IS+I       L  L  L +  N L +        FNL N+ ELS
Sbjct: 230 GLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYN---IFNLPNIVELS 286

Query: 232 LVRNSLTAAPVNLPGTNLRKLYLQDNHINRV 262
           +  N L  A   +P  NL  LYLQ+N I ++
Sbjct: 287 VGHNKLKQA-FYIP-RNLEHLYLQNNEIEKM 315


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score =  119 bits (297), Expect = 1e-26
 Identities = 107/398 (26%), Positives = 171/398 (42%), Gaps = 23/398 (5%)

Query: 19  LQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSD 78
           L +  L+   ++CP  CRCD   +YC       IP  I   +  L L+ N I      + 
Sbjct: 22  LLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK-SNQ 80

Query: 79  LKNLLKVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135
              L ++  +YL HN   S+DE      + +KEL L  N I  +   +   +P L  L L
Sbjct: 81  FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDL 140

Query: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISS 192
             N +  +  E+  F+    L +L L  N L T+P  +    R ++ L L  NR+ ++S 
Sbjct: 141 SYNKLQTLQSEQ--FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSR 198

Query: 193 PSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLR 250
            +  GL  LK L L+ N  +        F  L NL  + L  N + +    L  T  +L 
Sbjct: 199 NAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256

Query: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310
            L L  N I  + P  F  L  L +L++ +N L+N+ Q   +   ++  + L  N W C 
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316

Query: 311 CKMKWVRDWLQSLPVKVNVRGLM-CQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369
             +  +  WL++   K N    M C  P+ ++G  + D        +   I S +Q+   
Sbjct: 317 RSICPLFYWLKNF--KGNKESTMICAGPKHIQGEKVSDA------VETYNICSEVQVVNT 368

Query: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPS 407
             + + P   Q P  +  +P I  P +T+    T SPS
Sbjct: 369 ERSHLVPQTPQKPL-IIPRPTIFKPDVTQSTFETPSPS 405


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score =  119 bits (297), Expect = 1e-26
 Identities = 107/398 (26%), Positives = 171/398 (42%), Gaps = 23/398 (5%)

Query: 19  LQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSD 78
           L +  L+   ++CP  CRCD   +YC       IP  I   +  L L+ N I      + 
Sbjct: 22  LLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK-SNQ 80

Query: 79  LKNLLKVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135
              L ++  +YL HN   S+DE      + +KEL L  N I  +   +   +P L  L L
Sbjct: 81  FAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDL 140

Query: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISS 192
             N +  +  E+  F+    L +L L  N L T+P  +    R ++ L L  NR+ ++S 
Sbjct: 141 SYNKLQTLQSEQ--FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSR 198

Query: 193 PSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLR 250
            +  GL  LK L L+ N  +        F  L NL  + L  N + +    L  T  +L 
Sbjct: 199 NAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256

Query: 251 KLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCG 310
            L L  N I  + P  F  L  L +L++ +N L+N+ Q   +   ++  + L  N W C 
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316

Query: 311 CKMKWVRDWLQSLPVKVNVRGLM-CQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTA 369
             +  +  WL++   K N    M C  P+ ++G  + D        +   I S +Q+   
Sbjct: 317 RSICPLFYWLKNF--KGNKESTMICAGPKHIQGEKVSDA------VETYNICSEVQVVNT 368

Query: 370 IPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPS 407
             + + P   Q P  +  +P I  P +T+    T SPS
Sbjct: 369 ERSHLVPQTPQKPL-IIPRPTIFKPDVTQSTFETPSPS 405


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score =  116 bits (291), Expect = 6e-26
 Identities = 101/375 (26%), Positives = 168/375 (44%), Gaps = 16/375 (4%)

Query: 24  LSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL 83
           LS   + CP  CRC+   +YC  + L  IP+ I      L L+ N +      +  K L 
Sbjct: 27  LSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKY-NQFKGLN 85

Query: 84  KVERIYLYHN---SLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSV 140
           ++  +YL HN   ++DE   N  + +KEL L  N I     ++   +  L  L L  N +
Sbjct: 86  QLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQL 145

Query: 141 SAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQG 197
            ++  E+  FR    L  L L  N L TIP  +    R +E L L  NRI +++     G
Sbjct: 146 HSLGSEQ--FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAG 203

Query: 198 LTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLRKLYLQ 255
           +  LK L L+ N  +   L   +F  LV+L  L L  N ++     +  T  +L++L L 
Sbjct: 204 MIRLKELHLEHNQFSKLNLA--LFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLS 261

Query: 256 DNHINRVP-PNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314
            N I     P+ F  +  L RL++ +N L+ + Q I D   ++  + L  N W C   + 
Sbjct: 262 GNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNIC 321

Query: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTV 374
            + +WL+S    +    ++C +P++++G+ + D       C  S       +  A+P   
Sbjct: 322 SLVNWLKSFK-GLRENTIICASPKELQGVNVIDAVKNYSICGKS-TTERFDLARALPKPT 379

Query: 375 YPAQGQWPAPVTKQP 389
           +  +   P   +K P
Sbjct: 380 FKPKLPRPKHESKPP 394


>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
          Length = 545

 Score =  115 bits (289), Expect = 1e-25
 Identities = 118/458 (25%), Positives = 180/458 (39%), Gaps = 116/458 (25%)

Query: 1   MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPE-- 58
           M+  AW ++       L L   P    A+ CP  C C    ++C+D  L ++P  IP   
Sbjct: 1   MLPGAWLLWT-----SLLLLARP----AQPCPMGCDCFVQEVFCSDEELATVPLDIPPYT 51

Query: 59  ----------------------DATTLYLQNNQINN------AGIP--SDLK-------- 80
                                 + T +   N Q+         G+P   DL+        
Sbjct: 52  KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN 111

Query: 81  -------NLLKVERIYLYHNSLDEFPTNLPKYV---KELHLQENNIRTITYDSLSKIPYL 130
                  NL  + ++ L  N L+  P  L +++   + LHLQ N ++ +       + +L
Sbjct: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171

Query: 131 EELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRI 187
           + L+L  N ++   + E  F     L+ L LS N LS +P G+     +++EL LD N I
Sbjct: 172 KTLNLAQNLLA--QLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNI 229

Query: 188 STISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNL--- 244
           S +       L  L+RL L  N + +  L   +F +L NLT LSL  N L   P  L   
Sbjct: 230 SELPPQVFSQLFCLERLWLQRNAITHLPLS--IFASLGNLTFLSLQWNMLRVLPAGLFAH 287

Query: 245 ------------------PGT-----NLR------------------------KLYLQDN 257
                              GT     NLR                        KLYL  N
Sbjct: 288 TPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSN 347

Query: 258 HINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVR 317
           ++  + P  F  L +L  L +S N L+ LP+GIFD   N+  L L  NPW C C + ++ 
Sbjct: 348 NLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLF 407

Query: 318 DWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC 355
           +WLQ    ++      C  P  ++G  +  LN +   C
Sbjct: 408 NWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  112 bits (280), Expect = 1e-24
 Identities = 102/399 (25%), Positives = 170/399 (42%), Gaps = 57/399 (14%)

Query: 81  NLLKVERIYLYHNSLDEFPTNLPKYV---KELHLQENNIRTITYDSLSKIPYLEELHLDD 137
           +L+ + ++ L  NSL      + +++   + L L EN +  I   +   +  L+EL L  
Sbjct: 177 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 236

Query: 138 NSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP--------------------------- 170
           N +  +S   G F +++ L+ L+LS NH+S +P                           
Sbjct: 237 NQIGLLS--PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGI 294

Query: 171 WGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTEL 230
           +G    + EL L DN IS++       L  L+ L+L  N ++    G   F  L  L EL
Sbjct: 295 FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPG--AFNGLTELREL 352

Query: 231 SLVRNSLTAAPVNLPG--TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288
           SL  N+L     N+     NL+ + LQ+N + ++P N F+ +  L  + + NN L NLP 
Sbjct: 353 SLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL 412

Query: 289 GIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGL-MCQAPEKVRGMAIKD 347
           GIFD L  + +L L +NPW C   +  +R+WL     ++    + +C +P  VRG ++  
Sbjct: 413 GIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLII 472

Query: 348 LNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTT--GS 405
           +N                +  A+P+   P    +P           P  T    TT   S
Sbjct: 473 IN----------------VNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTS 516

Query: 406 PSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLG 444
           P      +T   VT D     W +    + L ++ + +G
Sbjct: 517 PVEDYTDLTTIQVTDD--RSVWGMTQAQSGLAIAAIVIG 553



 Score =  104 bits (260), Expect = 2e-22
 Identities = 92/331 (27%), Positives = 141/331 (42%), Gaps = 60/331 (18%)

Query: 31  CPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG--------------- 74
           CPS C C  A  + C    + ++PT +P +A +L + N  I                   
Sbjct: 31  CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90

Query: 75  --------IPSDLKNLLKVERIYLYHNSLDEFPTNL---------------------PKY 105
                    P   +NL  +  + L +N L   P  L                     P +
Sbjct: 91  EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150

Query: 106 ------VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLL 159
                 +KEL L  N++  I   +   +  L +L+L  NS++ +S     F+    L++L
Sbjct: 151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS--PRVFQHLGNLQVL 208

Query: 160 FLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGL 216
            L  N L+ IP G       ++EL L  N+I  +S        +L+RL L  N ++   L
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ--L 266

Query: 217 GDKVFFNLVNLTELSLVRNSLTAAPVNL--PGTNLRKLYLQDNHINRVPPNAFSYLRQLY 274
              +F  L  L  L+L  NSL    + +  P  NLR+L+L DNHI+ +P N FS LRQL 
Sbjct: 267 PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ 326

Query: 275 RLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
            L +S N +S +  G F+ L  + +L L  N
Sbjct: 327 VLILSRNQISFISPGAFNGLTELRELSLHTN 357


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  112 bits (280), Expect = 1e-24
 Identities = 102/399 (25%), Positives = 170/399 (42%), Gaps = 57/399 (14%)

Query: 81  NLLKVERIYLYHNSLDEFPTNLPKYV---KELHLQENNIRTITYDSLSKIPYLEELHLDD 137
           +L+ + ++ L  NSL      + +++   + L L EN +  I   +   +  L+EL L  
Sbjct: 171 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 230

Query: 138 NSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP--------------------------- 170
           N +  +S   G F +++ L+ L+LS NH+S +P                           
Sbjct: 231 NQIGLLS--PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGI 288

Query: 171 WGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTEL 230
           +G    + EL L DN IS++       L  L+ L+L  N ++    G   F  L  L EL
Sbjct: 289 FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPG--AFNGLTELREL 346

Query: 231 SLVRNSLTAAPVNLPG--TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288
           SL  N+L     N+     NL+ + LQ+N + ++P N F+ +  L  + + NN L NLP 
Sbjct: 347 SLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPL 406

Query: 289 GIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGL-MCQAPEKVRGMAIKD 347
           GIFD L  + +L L +NPW C   +  +R+WL     ++    + +C +P  VRG ++  
Sbjct: 407 GIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLII 466

Query: 348 LNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTT--GS 405
           +N                +  A+P+   P    +P           P  T    TT   S
Sbjct: 467 IN----------------VNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTS 510

Query: 406 PSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLG 444
           P      +T   VT D     W +    + L ++ + +G
Sbjct: 511 PVEDYTDLTTIQVTDD--RSVWGMTQAQSGLAIAAIVIG 547



 Score =  104 bits (260), Expect = 2e-22
 Identities = 92/331 (27%), Positives = 141/331 (42%), Gaps = 60/331 (18%)

Query: 31  CPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG--------------- 74
           CPS C C  A  + C    + ++PT +P +A +L + N  I                   
Sbjct: 25  CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84

Query: 75  --------IPSDLKNLLKVERIYLYHNSLDEFPTNL---------------------PKY 105
                    P   +NL  +  + L +N L   P  L                     P +
Sbjct: 85  EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144

Query: 106 ------VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLL 159
                 +KEL L  N++  I   +   +  L +L+L  NS++ +S     F+    L++L
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHIS--PRVFQHLGNLQVL 202

Query: 160 FLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGL 216
            L  N L+ IP G       ++EL L  N+I  +S        +L+RL L  N ++   L
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ--L 260

Query: 217 GDKVFFNLVNLTELSLVRNSLTAAPVNL--PGTNLRKLYLQDNHINRVPPNAFSYLRQLY 274
              +F  L  L  L+L  NSL    + +  P  NLR+L+L DNHI+ +P N FS LRQL 
Sbjct: 261 PPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQ 320

Query: 275 RLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
            L +S N +S +  G F+ L  + +L L  N
Sbjct: 321 VLILSRNQISFISPGAFNGLTELRELSLHTN 351


>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
          Length = 699

 Score =  109 bits (272), Expect = 9e-24
 Identities = 86/280 (30%), Positives = 130/280 (46%), Gaps = 27/280 (9%)

Query: 32  PSVCRCDAGFIYCNDRFLTSIP-----------------TGIPEDATT-------LYLQN 67
           PS C      I C +  LT IP                   IP++A         L L  
Sbjct: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376

Query: 68  NQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSK 126
           N I ++GI P   K L K+ R+ +  N+L + P+ LP  ++EL + ENN++ I  +SLS 
Sbjct: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436

Query: 127 IPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNR 186
           +  L  L L+ N++S  ++   AF+    L  L L +N    IP GLP +IEEL L++N+
Sbjct: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496

Query: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
           I  I+         +  +VL  N +  + +    + N  NL  + L  N L   P  LP 
Sbjct: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLP- 555

Query: 247 TNLRKLYLQDNHINRVPPNAFSYLRQ-LYRLDMSNNNLSN 285
            +L  L L  N I R+P   F ++   L  L +S N L++
Sbjct: 556 KSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLAD 595



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 64/219 (29%), Positives = 101/219 (46%), Gaps = 27/219 (12%)

Query: 95  LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
           L + P      +  L L  N+I +I  ++ + +P LE L L  N++++  I   AF+   
Sbjct: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393

Query: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
            L  L +  N+L  IP  LP T+EEL++++N +  I   SL  L  L  L L+GN L+  
Sbjct: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453

Query: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHI--------------- 259
            +    F  L +L  L L +N     P  LPG+ + +LYL++N I               
Sbjct: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGS-IEELYLENNQIEEITEICFNHTRKIN 512

Query: 260 -----------NRVPPNAFSYLRQLYRLDMSNNNLSNLP 287
                      NR+ P A+     L  +D+S N L ++P
Sbjct: 513 VIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVP 551



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 52/168 (30%), Positives = 73/168 (43%), Gaps = 29/168 (17%)

Query: 52  IPTGIPEDATTLYLQNNQIN-------------------------NAGIPSDLKNLLKVE 86
           IP G+P     LYL+NNQI                          N   P    N   +E
Sbjct: 479 IPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLE 538

Query: 87  RIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT-YDSLSKIPYLEELHLDDNSVSAVSI 145
            I L +N L   P+ LPK +  L L  N I  I  Y      P LE L+L  N ++   +
Sbjct: 539 SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGM 598

Query: 146 EEGAFRDSNY-LRLLFLSRNHLSTIPWGLP--RTIEELRLDDNRISTI 190
           +  +F  + + LR LFL  N L +IP G+   + +  LRL++N+I  I
Sbjct: 599 DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNI 646



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 25/140 (17%)

Query: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225
           L+ IP      I  L L  N I++I   +  GL +L+RL L  N + + G+G K F  L 
Sbjct: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393

Query: 226 NLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSN 285
            L  L++  N+L   P  LP T                         L  L ++ NNL  
Sbjct: 394 KLMRLNMDGNNLIQIPSQLPST-------------------------LEELKVNENNLQA 428

Query: 286 LPQGIFDDLDNITQLILRNN 305
           + +    DL+ +  L L  N
Sbjct: 429 IDEESLSDLNQLVTLELEGN 448


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score =  108 bits (271), Expect = 1e-23
 Identities = 145/594 (24%), Positives = 241/594 (40%), Gaps = 96/594 (16%)

Query: 29  KSCPSVCRCDAG-FIYCNDRFLTSIPTGIPEDATTLYLQNNQIN--NAGIPSDLKNLLKV 85
           + CPS C+C     ++C  R  T++P  +P D   LY+  N I   +AG  + L  L  +
Sbjct: 22  QGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLL 81

Query: 86  ERIYLYHNSLDEFPTNLPK---YVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSA 142
           +   L  N +   P+ + +    +  L L  N +  IT ++   +  LE L+L  N +  
Sbjct: 82  D---LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR- 137

Query: 143 VSIEEGAFRDSNYLRLLFLSRNHLSTIP-WGLPRTIEELRLDDNRISTISSPSLQGLTSL 201
             I+ GAF   + L  L L  N L  +P   LPR +  L L  N +  +  P +    ++
Sbjct: 138 -HIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLL-LDLSHNSLLALE-PGILDTANV 194

Query: 202 KRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTN-LRKLYLQDN-HI 259
           + L L G  L    L + +F  L NL +L +  N L   P  + G   L +L L  N  I
Sbjct: 195 EALRLAG--LGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNTRI 252

Query: 260 NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDW 319
            ++ P   + L  L  LD+SN +L  LP  +      +  L    NP+ C C + W   W
Sbjct: 253 AQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPW 312

Query: 320 LQSLPVKV-NVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQIT-------TAIP 371
           ++   V + +     C  P K  G  + +L+   F C  +   +T+  T       TA+ 
Sbjct: 313 VRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALS 372

Query: 372 NTVYPAQGQWPAPVTKQPD-----------IKNPK---------------LTKDH----- 400
           +++ P       P T+ P            +  P+                T+ H     
Sbjct: 373 SSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTCHLGTRHHLACLC 432

Query: 401 ---------------QTTGSPSRKT------ITITVKSVTSDTIHISWKLALPMTALRLS 439
                           T  SP+  T      +T+ ++ V+  ++ +  +  L  ++++L 
Sbjct: 433 PEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQGSSVQLR 492

Query: 440 WLKLGHSPAFGSITETI---VTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVC 496
            L+L +    G     +   +    +EY VT L P++ Y VC++P+    +   +E   C
Sbjct: 493 SLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGPGRVPEGEE--AC 550

Query: 497 IETETAPLRMYN--PTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALV 548
            E  T P    N  P T           +  NLPL  +I  A+A V +A LA V
Sbjct: 551 GEAHTPPAVHSNHAPVTQA---------REGNLPL--LIAPALAAVLLAALAAV 593


>gi|198041768 synleurin [Homo sapiens]
          Length = 622

 Score =  108 bits (269), Expect = 2e-23
 Identities = 119/488 (24%), Positives = 194/488 (39%), Gaps = 88/488 (18%)

Query: 31  CPSVCR-CDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQIN------------------ 71
           C SVC+ C    I C +  L+SIP   PE    LYL  N I+                  
Sbjct: 32  CSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYL 91

Query: 72  -NAGI----------------------------PSDLKNLLKVERIYLYHNSLDEFPTNL 102
            N+ I                            P   K LL +  +YL +N +   P  +
Sbjct: 92  DNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGV 151

Query: 103 PK---YVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLL 159
                 V+ L+LQ N +  +   +   +  L  L L +N++  +S  E  F+    L  L
Sbjct: 152 FNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRIS--ESGFQHLENLACL 209

Query: 160 FLSRNHLSTIP---WGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGL 216
           +L  N+L+ +P   + + +++  L L  N I  I   + +GL +L+ L+L  + + N  +
Sbjct: 210 YLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRN--V 267

Query: 217 GDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLRKLYLQDNHINRVPPNAFSYL-RQL 273
               F  + NL  L L  N L     +      NL  L L  N I  +  + F  +   L
Sbjct: 268 TRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASL 327

Query: 274 YRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLM 333
             L++S NNL+ L   +   L ++  L   +NPW C CK+  +RDWL S  + +N+    
Sbjct: 328 KILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNI---Y 384

Query: 334 CQAPEKVRGMAIKDLNAELFDCKDSGI-VSTIQITTAIPNTVYPAQG---QWPAPVTKQP 389
           CQ P  +RG A++ +N  + +C  S I VS        P+  +        W    T   
Sbjct: 385 CQNPPSMRGRALRYIN--ITNCVTSSINVSRAWAVVKSPHIHHKTTALMMAWHKVTTNGS 442

Query: 390 DIKNPKLTK----------------DHQTTGSPSRKT--ITITVKSVTSDTIHISWKLAL 431
            ++N +                        G+P   T  + + ++  TS T+++    AL
Sbjct: 443 PLENTETENITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSAL 502

Query: 432 PMTALRLS 439
           P  A  +S
Sbjct: 503 PNDAASMS 510


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score =  106 bits (265), Expect = 6e-23
 Identities = 84/262 (32%), Positives = 112/262 (42%), Gaps = 29/262 (11%)

Query: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL------- 83
           CP  C C    + C+D  L S+P  I  D T L LQNN I+      D K L        
Sbjct: 63  CPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELR-KDDFKGLQHLYALVL 121

Query: 84  -----------------KVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSK 126
                            K++++Y+  N L E P NLP  + EL + +N IR +     S 
Sbjct: 122 VNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSG 181

Query: 127 IPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNR 186
           +  +  + +  N +     E GAF D   L  L +S   L+ IP  LP T+ EL LD N+
Sbjct: 182 LRNMNCIEMGGNPLENSGFEPGAF-DGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNK 240

Query: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
           I  I    L   + L RL L  N +     G   F  L  L EL L  N L   P  LP 
Sbjct: 241 IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSF--LPTLRELHLDNNKLARVPSGLPD 298

Query: 247 TN-LRKLYLQDNHINRVPPNAF 267
              L+ +YL  N+I +V  N F
Sbjct: 299 LKLLQVVYLHSNNITKVGVNDF 320



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 52/162 (32%), Positives = 78/162 (48%), Gaps = 5/162 (3%)

Query: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194
           LD +SV+        F    +LR++  S   L ++P  +      L L +N IS +    
Sbjct: 50  LDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDD 109

Query: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYL 254
            +GL  L  LVL  N ++   + +K F  L  L +L + +N L   P NLP ++L +L +
Sbjct: 110 FKGLQHLYALVLVNNKISK--IHEKAFSPLRKLQKLYISKNHLVEIPPNLP-SSLVELRI 166

Query: 255 QDNHINRVPPNAFSYLRQLYRLDMSNNNLSN--LPQGIFDDL 294
            DN I +VP   FS LR +  ++M  N L N     G FD L
Sbjct: 167 HDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGL 208


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  106 bits (264), Expect = 8e-23
 Identities = 100/346 (28%), Positives = 156/346 (45%), Gaps = 28/346 (8%)

Query: 17  LFLQVAPLSVMAKSCPSVCRCDAG--FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
           L L        A+ CP  C CD     + C  + LT +P  IPE    L LQ N +    
Sbjct: 19  LLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKV-- 76

Query: 75  IPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKEL---HLQENNIRTITYDSLSKIPYL 130
           IP+   + +  +  + L H  ++       + +  L   +L  N++R +  ++L  +  L
Sbjct: 77  IPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSL 136

Query: 131 EELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP----WGLPRTIEELRLDDNR 186
             L L+ N++    +  G F     L  L L+ N L  +P     GL R +  LRL  N 
Sbjct: 137 RRLELEGNALE--ELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLR-VRWLRLSHNA 193

Query: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP----V 242
           +S ++  +L GL +L+RL L  N L    L   V      L  L L  N LT A     +
Sbjct: 194 LSVLAPEALAGLPALRRLSLHHNELQ--ALPGPVLSQARGLARLELGHNPLTYAGEEDGL 251

Query: 243 NLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLIL 302
            LPG  LR+L L    +  + P AF++  +L+ LD+  N L  LP         + +L L
Sbjct: 252 ALPG--LRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRL 307

Query: 303 RNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDL 348
           + NP +CGC+ + + +WL    V+ +     CQ P ++RG A+  L
Sbjct: 308 QGNPLWCGCQARPLLEWLARARVRSDG---ACQGPRRLRGEALDAL 350



 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 95/358 (26%), Positives = 149/358 (41%), Gaps = 64/358 (17%)

Query: 31  CPSVCRC--DAGFIYCNDRFLTSIPTGIPEDATTLYLQNN-------------------Q 69
           CP  C C  ++    C    L ++P G P D   L L+ N                    
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455

Query: 70  INNAGI----PSDLKNLLKVERIYLYHNSLDEFPT----NLPKYVKELHLQENNIRTITY 121
           + + GI       L  L ++  +YL  N L           P+ +  L+L+ N    +  
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPR-LGYLYLERNRFLQVPG 514

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIE 178
            +L  +P L  LHL DN+V  ++   G    +  LR ++LS N ++ +  G     R +E
Sbjct: 515 AALRALPSLFSLHLQDNAVDRLA--PGDLGRTRALRWVYLSGNRITEVSLGALGPARELE 572

Query: 179 ELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLT 238
           +L LD N++  + + +L+GL +L  L L GN L    L D  F                 
Sbjct: 573 KLHLDRNQLREVPTGALEGLPALLELQLSGNPL--RALRDGAF----------------- 613

Query: 239 AAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQ-LYRLDMSNNNLSNLPQGIFDDLDNI 297
             PV   G +L+ L+L  + + ++ P AFS L   L  L +  N L  LP      L  +
Sbjct: 614 -QPV---GRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQL 667

Query: 298 TQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC 355
             + L +NP++C C++  +  WL  L ++V   G  C  P   RG  +K   A   DC
Sbjct: 668 ELIDLSSNPFHCDCQLLPLHRWLTGLNLRV---GATCATPPNARGQRVKAAAAVFEDC 722


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  105 bits (261), Expect = 2e-22
 Identities = 90/305 (29%), Positives = 146/305 (47%), Gaps = 32/305 (10%)

Query: 29  KSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERI 88
           + CP+ CRC    + C+ + L  +P  +P     L L +N+++     S + +L  +  +
Sbjct: 45  RPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIK-ASSMSHLQSLREV 103

Query: 89  YLYHNSLDEFPTNLP--KYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVS----- 141
            L +N L+  P   P    +  L L  N I  I  + L +   LE L L  N++S     
Sbjct: 104 KLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA 163

Query: 142 ---------------AVSIEEGAFRD-SNYLRLLFLSRNHLSTIP---WGLPRTIEELRL 182
                            S+E G F + +N L +L L+RN +S IP   + LP+ ++ L L
Sbjct: 164 FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQ-LQHLEL 222

Query: 183 DDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPV 242
           + N+I  +   + QGL +LK L +  N +    L D  F+ L N+  L L  N+LT    
Sbjct: 223 NRNKIKNVDGLTFQGLGALKSLKMQRNGVTK--LMDGAFWGLSNMEILQLDHNNLTEITK 280

Query: 243 N-LPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300
             L G   L++L+L  N INR+ P+A+ + ++L  LD++ N+LS L    F  L  +  L
Sbjct: 281 GWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTL 340

Query: 301 ILRNN 305
            + NN
Sbjct: 341 HIGNN 345



 Score =  100 bits (248), Expect = 5e-21
 Identities = 84/330 (25%), Positives = 152/330 (46%), Gaps = 18/330 (5%)

Query: 41  FIYCNDRFLTSIPTGIPEDA--TTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSL--- 95
           ++Y N   +TS+  G  ++   T L L+ N+   + IP  +  L +++ + L  N +   
Sbjct: 171 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNV 230

Query: 96  DEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNY 155
           D         +K L +Q N +  +   +   +  +E L LD N+++ ++  +G       
Sbjct: 231 DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT--KGWLYGLLM 288

Query: 156 LRLLFLSRNHLSTIP---WGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLN 212
           L+ L LS+N ++ I    W   + + EL L  N +S +   S  GL+ L  L +  N ++
Sbjct: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348

Query: 213 NHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT-----NLRKLYLQDNHINRVPPNAF 267
              + D  F  L +L  L L  N ++    ++ G       LR+L LQ N I  +   AF
Sbjct: 349 Y--IADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAF 406

Query: 268 SYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV 327
           + L  L  LD+S+N + +L    F  +  + QL L  +   C C++KW+  W+     + 
Sbjct: 407 TGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQS 466

Query: 328 NVRGLMCQAPEKVRGMAIKDLNAELFDCKD 357
            V    C  P+ ++G +I  ++ + F C D
Sbjct: 467 FVNA-SCAHPQLLKGRSIFAVSPDGFVCDD 495


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score =  104 bits (260), Expect = 2e-22
 Identities = 95/361 (26%), Positives = 155/361 (42%), Gaps = 15/361 (4%)

Query: 24  LSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL 83
           L  +  +CP  CRC+    YC+ +   S+P    + +  L L++N I          +  
Sbjct: 27  LPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELE-RDQFASFS 85

Query: 84  KVERIYLYHNSLDEFPTNLPK---YVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSV 140
           ++  ++L HN +     +  +    +KEL L  N I  +   + +++  L+ L L  N +
Sbjct: 86  QLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQL 145

Query: 141 SAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGL---PRTIEELRLDDNRISTISSPSLQG 197
           S++  E   F     L+ L L  N L TIP  L    R++E L L  NR+ +++     G
Sbjct: 146 SSLHPE--LFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAG 203

Query: 198 LTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT--NLRKLYLQ 255
           L  L+ L L+ N L         F  L +L  L L  N ++     +  T   L KL L 
Sbjct: 204 LIKLRELHLEHNQLTKINFAH--FLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLT 261

Query: 256 DNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKW 315
            N I  +    F  +  L  L M NN L++L   I + L ++T + L  N W C  ++  
Sbjct: 262 GNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICA 321

Query: 316 VRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITT-AIPNTV 374
           +  WL S   +     ++C +P+  +G  I D       C +     T+  TT   P T 
Sbjct: 322 LASWLGSFQGRWE-HSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTE 380

Query: 375 Y 375
           Y
Sbjct: 381 Y 381


>gi|5901992 keratocan [Homo sapiens]
          Length = 352

 Score =  104 bits (260), Expect = 2e-22
 Identities = 71/220 (32%), Positives = 113/220 (51%), Gaps = 5/220 (2%)

Query: 88  IYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEE 147
           +Y  +  L E P  +P  +  L+LQ N I TI          L  ++L+ N ++   IE+
Sbjct: 56  LYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114

Query: 148 GAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLD 207
           GA      L  LFL  N L  +P  LPR++E+L+L  N++S I   +   L +L  L L 
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQ 174

Query: 208 GNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAF 267
            N L ++      F  L NL +L++ +N+L   P  LP  N  +L+L +N I  +P N F
Sbjct: 175 NNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLP-ANTMQLFLDNNSIEGIPENYF 233

Query: 268 SYLRQLYRLDMSNNNLSN--LPQGIFDDLDNITQLILRNN 305
           + + ++  L +++N LS+  LP   F D+ +I  L L +N
Sbjct: 234 NVIPKVAFLRLNHNKLSDEGLPSRGF-DVSSILDLQLSHN 272



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 75/260 (28%), Positives = 115/260 (44%), Gaps = 32/260 (12%)

Query: 31  CPSVCRCDAGF---IYCNDRFLTSIPTGIPEDATTLYLQNN------------------- 68
           CP  C C   F   +YC +R L  IP  IP     LYLQNN                   
Sbjct: 42  CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100

Query: 69  -----QINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYD 122
                +I N GI    L  L K+  ++L  N L+E P+ LP+ +++L L  N +  I   
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160

Query: 123 SLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRL 182
           + S +  L  L L +N +   + +   F+    L  L +++N L  +P  LP    +L L
Sbjct: 161 TFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFL 220

Query: 183 DDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPV 242
           D+N I  I       +  +  L L+ N L++ GL  +  F++ ++ +L L  N LT  P 
Sbjct: 221 DNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSR-GFDVSSILDLQLSHNQLTKVP- 278

Query: 243 NLPGTNLRKLYLQDNHINRV 262
                +L+ L+L  N I  V
Sbjct: 279 -RISAHLQHLHLDHNKIKSV 297



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 28/145 (19%)

Query: 49  LTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL-KVERIYLYHNSLDE--FPTNLPKY 105
           L ++P  +P +   L+L NN I   GIP +  N++ KV  + L HN L +   P+     
Sbjct: 204 LRNMPPRLPANTMQLFLDNNSIE--GIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDV 261

Query: 106 VKELHLQENNIRTITYDSLSKIP----YLEELHLDDNSVSAVSI------------EEGA 149
              L LQ      ++++ L+K+P    +L+ LHLD N + +V++            E  +
Sbjct: 262 SSILDLQ------LSHNQLTKVPRISAHLQHLHLDHNKIKSVNVSVICPSPSMLPAERDS 315

Query: 150 FRDSNYLRLLFLSRNHLS-TIPWGL 173
           F    +LR L L  N +   IP  L
Sbjct: 316 FSYGPHLRYLRLDGNEIKPPIPMAL 340


>gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]
          Length = 421

 Score =  104 bits (259), Expect = 3e-22
 Identities = 90/302 (29%), Positives = 129/302 (42%), Gaps = 37/302 (12%)

Query: 24  LSVMAKSCPSVCRCD-AGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNL 82
           L  + ++CP  C C     + C+   L   P  I   A  L LQNNQ+      ++L  L
Sbjct: 37  LQPLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPY-NELSRL 95

Query: 83  LKVERIYLYHN--SLDEFPTNLPKYVKEL------HLQENNIRTITYDSLSKIPYLEELH 134
             +  + L++N  S +  P    + + +L      H + N I  +   +LS+   L EL+
Sbjct: 96  SGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNLISKVPRGALSRQTQLRELY 155

Query: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194
           L  N ++   ++   F   + L  L LS N L+T+P GLPRT+  L L  NRI  + +  
Sbjct: 156 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAAR 215

Query: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYL 254
           L G   L+ L+L  N L + GL       L  L  L L  N L   P  LP   LR L L
Sbjct: 216 LHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALP-RRLRALVL 274

Query: 255 QDNHI--------------------------NRVPPNAFSYLRQLYRLDMSNNNLSNLPQ 288
             NH+                           RV   AF  LR L  LD++ N L+ LP 
Sbjct: 275 PHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM 334

Query: 289 GI 290
           G+
Sbjct: 335 GL 336



 Score =  103 bits (257), Expect = 5e-22
 Identities = 76/242 (31%), Positives = 110/242 (45%), Gaps = 5/242 (2%)

Query: 46  DRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTN 101
           +  ++ +P G     T L   YLQ+NQ+ ++G+ +     L  +E + L HN L   P  
Sbjct: 134 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG 193

Query: 102 LPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFL 161
           LP+ +  LHL  N IR +    L     L  L L  N + +  +  GA R    L  L L
Sbjct: 194 LPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHL 253

Query: 162 SRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVF 221
             N L  +P  LPR +  L L  N ++ + +  L     L  L L  N L +  +  + F
Sbjct: 254 YGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAF 313

Query: 222 FNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281
             L  L  L L  N LT  P+ LP T LR L LQ N +  + P   + L QL  L +++N
Sbjct: 314 RRLRALRSLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHN 372

Query: 282 NL 283
            L
Sbjct: 373 RL 374



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 58/181 (32%), Positives = 93/181 (51%), Gaps = 2/181 (1%)

Query: 63  LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
           L LQ+NQ+ ++G+P+  L+ L  +  ++LY N LD  P  LP+ ++ L L  N++  +  
Sbjct: 225 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 284

Query: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
             L   P L EL+L  N +++  +   AFR    LR L L+ N L+ +P GLP  +  L+
Sbjct: 285 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 344

Query: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNL-TELSLVRNSLTAA 240
           L  N++  +    L GL  L+ L L  N L    +G   +  L  L     LV +++  A
Sbjct: 345 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRA 404

Query: 241 P 241
           P
Sbjct: 405 P 405



 Score = 34.3 bits (77), Expect = 0.37
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 7/83 (8%)

Query: 230 LSLVRNSLTAAPVNLPG--TNLRKLYLQDNHINR--VPPNAFSYLRQLYRLDMS---NNN 282
           LSL  N L   P N     + LR L L +N I+   +P  AF  L QL  L ++   NN 
Sbjct: 77  LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKNNL 136

Query: 283 LSNLPQGIFDDLDNITQLILRNN 305
           +S +P+G       + +L L++N
Sbjct: 137 ISKVPRGALSRQTQLRELYLQHN 159


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,903,321
Number of Sequences: 37866
Number of extensions: 1138688
Number of successful extensions: 5472
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 2963
Number of HSP's gapped (non-prelim): 992
length of query: 649
length of database: 18,247,518
effective HSP length: 109
effective length of query: 540
effective length of database: 14,120,124
effective search space: 7624866960
effective search space used: 7624866960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.