Guide to the Human Genome
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Search of human proteins with 13899229

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13899229 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, zeta isoform a [Homo sapiens]
         (718 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13899229 nuclear factor of kappa light polypeptide gene enhan...  1444   0.0  
gi|53832024 nuclear factor of kappa light polypeptide gene enhan...  1244   0.0  
gi|41281709 nuclear factor of kappa light polypeptide gene enhan...   206   8e-53
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]                     113   7e-25
gi|117320531 nuclear factor of kappa light polypeptide gene enha...   101   3e-21
gi|117320540 nuclear factor of kappa light polypeptide gene enha...   101   3e-21
gi|117320527 nuclear factor of kappa light polypeptide gene enha...   101   3e-21
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]           94   3e-19
gi|71274109 nuclear factor of kappa light polypeptide gene enhan...    91   4e-18
gi|10092619 nuclear factor of kappa light polypeptide gene enhan...    89   1e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        82   2e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         82   2e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         82   2e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         82   2e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         82   2e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        79   1e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         79   1e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         79   1e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         77   6e-14
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     76   9e-14
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    75   2e-13
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    74   4e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    72   1e-12
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    71   3e-12
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     71   3e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   69   1e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    69   2e-11
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    68   3e-11
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           67   4e-11
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...    67   6e-11

>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform a [Homo sapiens]
          Length = 718

 Score = 1444 bits (3739), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP 60
           MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP
Sbjct: 1   MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP 60

Query: 61  GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV 120
           GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV
Sbjct: 61  GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV 120

Query: 121 KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP 180
           KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP
Sbjct: 121 KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP 180

Query: 181 ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL 240
           ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL
Sbjct: 181 ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL 240

Query: 241 NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP 300
           NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP
Sbjct: 241 NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP 300

Query: 301 HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS 360
           HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS
Sbjct: 301 HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS 360

Query: 361 SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW 420
           SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW
Sbjct: 361 SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW 420

Query: 421 QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG 480
           QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG
Sbjct: 421 QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG 480

Query: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540
           QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN
Sbjct: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540

Query: 541 QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ 600
           QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ
Sbjct: 541 QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ 600

Query: 601 MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ 660
           MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ
Sbjct: 601 MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ 660

Query: 661 YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY 718
           YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
Sbjct: 661 YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY 718


>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform b [Homo sapiens]
          Length = 618

 Score = 1244 bits (3219), Expect = 0.0
 Identities = 618/618 (100%), Positives = 618/618 (100%)

Query: 101 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 160
           MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS
Sbjct: 1   MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 60

Query: 161 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 220
           YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI
Sbjct: 61  YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 120

Query: 221 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 280
           INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM
Sbjct: 121 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 180

Query: 281 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 340
           IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL
Sbjct: 181 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 240

Query: 341 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 400
           VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP
Sbjct: 241 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 300

Query: 401 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 460
           FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS
Sbjct: 301 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 360

Query: 461 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 520
           YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC
Sbjct: 361 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 420

Query: 521 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 580
           AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE
Sbjct: 421 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 480

Query: 581 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 640
           VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS
Sbjct: 481 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540

Query: 641 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
           FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE
Sbjct: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600

Query: 701 QIRRILKGKSIQQRAPPY 718
           QIRRILKGKSIQQRAPPY
Sbjct: 601 QIRRILKGKSIQQRAPPY 618


>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, delta [Homo sapiens]
          Length = 313

 Score =  206 bits (523), Expect = 8e-53
 Identities = 126/298 (42%), Positives = 178/298 (59%), Gaps = 17/298 (5%)

Query: 422 VEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQ 481
           +E   + +  +   Q L++D +GDT LH+  A+G R  +Y  A  +     LDI+EH G+
Sbjct: 27  LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86

Query: 482 SAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQ 541
           +   VA AANQ LIV+DL+N+GA+ N  D  GR+ LHV A  G   VL A+    + S  
Sbjct: 87  TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV----LNSGV 142

Query: 542 FVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM 601
            VDLEA +++GLTPLH A++A N  +       +P     + L  + +  +D +  L+QM
Sbjct: 143 QVDLEARDFEGLTPLHTAILALNVAM-------RPSDLCPRVLSTQARDRLDCVHMLLQM 195

Query: 602 GAAVEAKDRKSGRTALHLAAEEANLELIRLFLELP--SCLSFVNAKAYNGNTALHVAASL 659
           GA   +++ KS +T LHLA + AN  L++L LELP     +FVN KA+ GNTALH+AA+L
Sbjct: 196 GANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAAL 254

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPP 717
                Q   VR L+  GADP+ RNLENEQPVHL+  GP  E +R++LK   +   APP
Sbjct: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV---APP 309


>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
          Length = 454

 Score =  113 bits (282), Expect = 7e-25
 Identities = 97/312 (31%), Positives = 140/312 (44%), Gaps = 43/312 (13%)

Query: 400 PFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRAL 459
           P   MG+P     L   L+      E    A+I+       D DGDT LHIAV QG    
Sbjct: 93  PTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMAT--RADEDGDTPLHIAVVQGNLPA 150

Query: 460 SYVLARKMN-ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLH 518
            + L          LDI  +  Q+   +AV      +V+ LV  GA     D  G+T  H
Sbjct: 151 VHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAH 210

Query: 519 VCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHS 578
           +  E      L+A+   A      +DLEA NYDGLT LH AV                  
Sbjct: 211 LACEHRSPTCLRALLDSAAPGT--LDLEARNYDGLTALHVAV------------------ 250

Query: 579 PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSC 638
                    N    +T++ L++ GA ++A D KSGR+ L  A E  +L +++L L+    
Sbjct: 251 ---------NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG-- 299

Query: 639 LSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPV 698
            + VNA+ Y+G++ALH A+        L  VR L+R GAD S +N  N+ P+ +      
Sbjct: 300 -ANVNAQMYSGSSALHSASGRGL----LPLVRTLVRSGADSSLKNCHNDTPLMVAR---- 350

Query: 699 GEQIRRILKGKS 710
             ++  IL+GK+
Sbjct: 351 SRRVIDILRGKA 362


>gi|117320531 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform a [Homo sapiens]
          Length = 900

 Score =  101 bits (251), Expect = 3e-21
 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)

Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
           ++L  + V  +   L    +    ++D +GDT LH+A+  G+ +    + YV+    + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
            ++++  H  Q+   +AV   Q  +V  L+ +GA     D  G + +H+   A  G  ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577

Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
           L+A+ Q GA    Q   L   +++GL P+H AV A               SPE  +LL  
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619

Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
                      +  GA VEA +R+ GRTALHLA E   L L+     +    + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666

Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
            GNT LH+AA L Y        RLL++ GAD    + ENE+P+  +P  P  +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712


>gi|117320540 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  101 bits (251), Expect = 3e-21
 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)

Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
           ++L  + V  +   L    +    ++D +GDT LH+A+  G+ +    + YV+    + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
            ++++  H  Q+   +AV   Q  +V  L+ +GA     D  G + +H+   A  G  ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577

Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
           L+A+ Q GA    Q   L   +++GL P+H AV A               SPE  +LL  
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619

Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
                      +  GA VEA +R+ GRTALHLA E   L L+     +    + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666

Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
            GNT LH+AA L Y        RLL++ GAD    + ENE+P+  +P  P  +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712


>gi|117320527 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  101 bits (251), Expect = 3e-21
 Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)

Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
           ++L  + V  +   L    +    ++D +GDT LH+A+  G+ +    + YV+    + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
            ++++  H  Q+   +AV   Q  +V  L+ +GA     D  G + +H+   A  G  ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577

Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
           L+A+ Q GA    Q   L   +++GL P+H AV A               SPE  +LL  
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619

Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
                      +  GA VEA +R+ GRTALHLA E   L L+     +    + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666

Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
            GNT LH+AA L Y        RLL++ GAD    + ENE+P+  +P  P  +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712


>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
          Length = 969

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 77/273 (28%), Positives = 128/273 (46%), Gaps = 39/273 (14%)

Query: 416 SLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNAL---HM 472
           +LF + V  +   L  + +     +D +GD+ LH+A+      L   L    + L    +
Sbjct: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575

Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
           ++++    Q+   +AV   Q  +V+DL+  GA ++  D  G + LH+ A++GH +VL  +
Sbjct: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635

Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
            K    +   + L+  N DGL  +H A+++++                           +
Sbjct: 636 LKHKKAA---LLLDHPNGDGLNAIHLAMMSNS---------------------------L 665

Query: 593 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 652
             +  L+  GA V A+++KSGRTALHLA E  N+ L    L      + V++  Y+G T 
Sbjct: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGD--AHVDSTTYDGTTP 723

Query: 653 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLE 685
           LH+AA      T+L A  LL   GADP   N E
Sbjct: 724 LHIAAG--RGSTRLAA--LLKAAGADPLVENFE 752



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 595 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCL---SFVNAKAYNGNT 651
           +K L+ +   + A   ++G + LHLA    + +L+R  LE+ S L     +N +     T
Sbjct: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585

Query: 652 ALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGK 709
            LH+A   +    Q D V  L+R GAD S  +      +HL       + +  +LK K
Sbjct: 586 PLHLAVITK----QEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK 639


>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, epsilon [Homo sapiens]
          Length = 500

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 80/260 (30%), Positives = 122/260 (46%), Gaps = 39/260 (15%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           DGDT +H+AV     A+  +    +    +LDI+ +  Q+A  +AV  +Q   V+ LV  
Sbjct: 258 DGDTLVHLAVIHEAPAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAV----GSNQFVDLEATNYDGLTPLHC 558
           GA     D  G T LHV  ++ H    + + +G      G++  +DL+  N+ GL  LH 
Sbjct: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376

Query: 559 AVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALH 618
           A          LQ+NQ      + ELLL+N             GA ++ ++  SG+TALH
Sbjct: 377 AT---------LQKNQP-----LMELLLRN-------------GADIDVQEGTSGKTALH 409

Query: 619 LAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGAD 678
           LA E     L++  L+     + V+A+  NG T LH+AA        +     L + GAD
Sbjct: 410 LAVETQERGLVQFLLQAG---AQVDARMLNGCTPLHLAAGRGL----MGISSTLCKAGAD 462

Query: 679 PSTRNLENEQPVHLVPDGPV 698
              RN+E+E P  L  +  V
Sbjct: 463 SLLRNVEDETPQDLTEESLV 482


>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, alpha [Homo sapiens]
          Length = 317

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 39/283 (13%)

Query: 412 QLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA-L 470
           Q+ K L + ++E +E    +    Q L++D  GD+FLH+A+    +AL+  + R++   L
Sbjct: 44  QMVKELQEIRLEPQEVPRGSEPWKQQLTED--GDSFLHLAIIHEEKALTMEVIRQVKGDL 101

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 530
             L+ + +  Q+   +AV  NQ  I + L+  G      D  G TPLH+  E+G    + 
Sbjct: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161

Query: 531 AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKS 590
            + +     +    L+ATNY+G T LH A I                             
Sbjct: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASI---------------------------HG 194

Query: 591 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
            +  ++ L+ +GA V A++  +GRTALHLA +  N +L+ L L+   C + VN   Y G 
Sbjct: 195 YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK---CGADVNRVTYQGY 251

Query: 651 TALHV-----AASLQYRLTQLDAVRL-LMRKGADPSTRNLENE 687
           +   +     +  +Q +L QL    L ++ +  D  + + E+E
Sbjct: 252 SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESE 294



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 11/86 (12%)

Query: 611 KSGRTALHLAA----EEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQL 666
           + G + LHLA     +   +E+IR   ++   L+F+N +     T LH+A        Q 
Sbjct: 72  EDGDSFLHLAIIHEEKALTMEVIR---QVKGDLAFLNFQNNLQQTPLHLAVITN----QP 124

Query: 667 DAVRLLMRKGADPSTRNLENEQPVHL 692
           +    L+  G DP  R+     P+HL
Sbjct: 125 EIAEALLGAGCDPELRDFRGNTPLHL 150


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A  +G   +   L  K     +L+     G +A  +A  A Q  +V++LVN GA VN
Sbjct: 82  LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
                G TPL++ A++ H +V++ + +   G+NQ V  E    DG TPL       H  V
Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 192

Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           +AH              +H   RN    +  V   LL+N    D +              
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 236

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
            K+G T LH+AA   NL + +L L   + ++F      NG T LH+A+    R   +  V
Sbjct: 237 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 288

Query: 670 RLLMRKGADPSTRNLENEQPVH 691
           RLL+ +GA   T+  +   P+H
Sbjct: 289 RLLLDRGAQIETKTKDELTPLH 310



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S+  +G T LHIA  +    +  +L +   ++   D    +G +   VA       IV++
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 455

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L+  GA  N ++    TPLH+ A  GH++V + + +     N      A   D  TPLHC
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 509

Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
           A  I H N V   L+ N  P+    +      +   +  V+T+  L++  A+ +A   K 
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 568

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LH+AA+   + +  L LE     +  NA   NG T LHVA         LD V+LL
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 621

Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           + +G  P +       P+H+       E  R +L+
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           +G T LH+AV      +  +L  +  + H       NG +   +A   NQ  + + L+  
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 657

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
           G   N     G TPLH+ A++GH++++  +       N        N  GLTPLH     
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 709

Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
                      Q+ H P V ++L+K+  +VD                 + G T LH+A+ 
Sbjct: 710 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 743

Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
             N++L++  L+     + VNAK   G + LH AA   +     D V LL++ GA P+  
Sbjct: 744 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 796

Query: 683 NLENEQPV 690
           + +   P+
Sbjct: 797 SSDGTTPL 804



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)

Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
           Q  +K  D  T LH A   G   +S +L   ++    +  K  NG S   +A   +    
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
           V+ L+   A+++       TPLHV A  GH +V + +  KGA  +++ ++       G T
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 406

Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
           PLH A   ++  V EL          V E  L    +         +K L+Q GA+    
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           + K   T LH+AA   + E+ +  L+  +    VNAKA +  T LH AA    R+   + 
Sbjct: 467 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 518

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
           V+LL+   A+P+        P+H+       E +  +L+ ++ Q
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L N      LSK   G T LHIA       ++ +L   +N    ++    NG +   +A 
Sbjct: 226 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 280

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
                ++V+ L++ GAQ+ T      TPLH  A  GH ++ + +       +    ++A 
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 334

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
             +GL+P+H A    +    +  R    +  E+ ++ L + + +            K L+
Sbjct: 335 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
             GA   ++   +G T LH+A ++ ++ ++ L L+  +    ++A   +G T LHVA+ +
Sbjct: 392 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 447

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
            +    L  V+ L+++GA P+  N++ E P+H+       E  + +L+ K+
Sbjct: 448 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA     H + + L++ GA+ N+    G TPLH+  +K H +V++ + K          +
Sbjct: 377 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 430

Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
           +A    GLTPLH A  + H  +V   LQR   P+   V+      +       +  K L+
Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q  A V AK  K  +T LH AA   +  +++L LE     +  N     G+T LH+AA  
Sbjct: 491 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 544

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             R   ++ V  L+ K A  +    +   P+H+
Sbjct: 545 --REGHVETVLALLEKEASQACMTKKGFTPLHV 575


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A  +G   +   L  K     +L+     G +A  +A  A Q  +V++LVN GA VN
Sbjct: 49  LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
                G TPL++ A++ H +V++ + +   G+NQ V  E    DG TPL       H  V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159

Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           +AH              +H   RN    +  V   LL+N    D +              
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
            K+G T LH+AA   NL + +L L   + ++F      NG T LH+A+    R   +  V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255

Query: 670 RLLMRKGADPSTRNLENEQPVH 691
           RLL+ +GA   T+  +   P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S+  +G T LHIA  +    +  +L +   ++   D    +G +   VA       IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L+  GA  N ++    TPLH+ A  GH++V + + +     N      A   D  TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476

Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
           A  I H N V   L+ N  P+    +      +   +  V+T+  L++  A+ +A   K 
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LH+AA+   + +  L LE     +  NA   NG T LHVA         LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588

Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           + +G  P +       P+H+       E  R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           +G T LH+AV      +  +L  +  + H       NG +   +A   NQ  + + L+  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
           G   N     G TPLH+ A++GH++++  +       N        N  GLTPLH     
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676

Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
                      Q+ H P V ++L+K+  +VD                 + G T LH+A+ 
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710

Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
             N++L++  L+     + VNAK   G + LH AA   +     D V LL++ GA P+  
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763

Query: 683 NLENEQPV 690
           + +   P+
Sbjct: 764 SSDGTTPL 771



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)

Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
           Q  +K  D  T LH A   G   +S +L   ++    +  K  NG S   +A   +    
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
           V+ L+   A+++       TPLHV A  GH +V + +  KGA  +++ ++       G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373

Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
           PLH A   ++  V EL          V E  L    +         +K L+Q GA+    
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           + K   T LH+AA   + E+ +  L+  +    VNAKA +  T LH AA    R+   + 
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
           V+LL+   A+P+        P+H+       E +  +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L N      LSK   G T LHIA       ++ +L   +N    ++    NG +   +A 
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
                ++V+ L++ GAQ+ T      TPLH  A  GH ++ + +       +    ++A 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
             +GL+P+H A    +    +  R    +  E+ ++ L + + +            K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
             GA   ++   +G T LH+A ++ ++ ++ L L+  +    ++A   +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
            +    L  V+ L+++GA P+  N++ E P+H+       E  + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA     H + + L++ GA+ N+    G TPLH+  +K H +V++ + K          +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397

Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
           +A    GLTPLH A  + H  +V   LQR   P+   V+      +       +  K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q  A V AK  K  +T LH AA   +  +++L LE     +  N     G+T LH+AA  
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             R   ++ V  L+ K A  +    +   P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
           + +  +E +  ++F  A  +       D +  G  +NT +  G   LH+ +++GH   V+
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62

Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
           + + K  +       LE T   G T LH A +A  + VV E                   
Sbjct: 63  ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96

Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
                    L+  GA V A+ +K G T L++AA+E +LE+++  LE
Sbjct: 97  ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A  +G   +   L  K     +L+     G +A  +A  A Q  +V++LVN GA VN
Sbjct: 49  LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
                G TPL++ A++ H +V++ + +   G+NQ V  E    DG TPL       H  V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159

Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           +AH              +H   RN    +  V   LL+N    D +              
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
            K+G T LH+AA   NL + +L L   + ++F      NG T LH+A+    R   +  V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255

Query: 670 RLLMRKGADPSTRNLENEQPVH 691
           RLL+ +GA   T+  +   P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S+  +G T LHIA  +    +  +L +   ++   D    +G +   VA       IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L+  GA  N ++    TPLH+ A  GH++V + + +     N      A   D  TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476

Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
           A  I H N V   L+ N  P+    +      +   +  V+T+  L++  A+ +A   K 
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LH+AA+   + +  L LE     +  NA   NG T LHVA         LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588

Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           + +G  P +       P+H+       E  R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           +G T LH+AV      +  +L  +  + H       NG +   +A   NQ  + + L+  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
           G   N     G TPLH+ A++GH++++  +       N        N  GLTPLH     
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676

Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
                      Q+ H P V ++L+K+  +VD                 + G T LH+A+ 
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710

Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
             N++L++  L+     + VNAK   G + LH AA   +     D V LL++ GA P+  
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763

Query: 683 NLENEQPV 690
           + +   P+
Sbjct: 764 SSDGTTPL 771



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)

Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
           Q  +K  D  T LH A   G   +S +L   ++    +  K  NG S   +A   +    
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
           V+ L+   A+++       TPLHV A  GH +V + +  KGA  +++ ++       G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373

Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
           PLH A   ++  V EL          V E  L    +         +K L+Q GA+    
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           + K   T LH+AA   + E+ +  L+  +    VNAKA +  T LH AA    R+   + 
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
           V+LL+   A+P+        P+H+       E +  +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L N      LSK   G T LHIA       ++ +L   +N    ++    NG +   +A 
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
                ++V+ L++ GAQ+ T      TPLH  A  GH ++ + +       +    ++A 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
             +GL+P+H A    +    +  R    +  E+ ++ L + + +            K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
             GA   ++   +G T LH+A ++ ++ ++ L L+  +    ++A   +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
            +    L  V+ L+++GA P+  N++ E P+H+       E  + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA     H + + L++ GA+ N+    G TPLH+  +K H +V++ + K          +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397

Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
           +A    GLTPLH A  + H  +V   LQR   P+   V+      +       +  K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q  A V AK  K  +T LH AA   +  +++L LE     +  N     G+T LH+AA  
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             R   ++ V  L+ K A  +    +   P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
           + +  +E +  ++F  A  +       D +  G  +NT +  G   LH+ +++GH   V+
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62

Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
           + + K  +       LE T   G T LH A +A  + VV E                   
Sbjct: 63  ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96

Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
                    L+  GA V A+ +K G T L++AA+E +LE+++  LE
Sbjct: 97  ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A  +G   +   L  K     +L+     G +A  +A  A Q  +V++LVN GA VN
Sbjct: 49  LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
                G TPL++ A++ H +V++ + +   G+NQ V  E    DG TPL       H  V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159

Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           +AH              +H   RN    +  V   LL+N    D +              
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
            K+G T LH+AA   NL + +L L   + ++F      NG T LH+A+    R   +  V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255

Query: 670 RLLMRKGADPSTRNLENEQPVH 691
           RLL+ +GA   T+  +   P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S+  +G T LHIA  +    +  +L +   ++   D    +G +   VA       IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L+  GA  N ++    TPLH+ A  GH++V + + +     N      A   D  TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476

Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
           A  I H N V   L+ N  P+    +      +   +  V+T+  L++  A+ +A   K 
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LH+AA+   + +  L LE     +  NA   NG T LHVA         LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588

Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           + +G  P +       P+H+       E  R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           +G T LH+AV      +  +L  +  + H       NG +   +A   NQ  + + L+  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
           G   N     G TPLH+ A++GH++++  +       N        N  GLTPLH     
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676

Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
                      Q+ H P V ++L+K+  +VD                 + G T LH+A+ 
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710

Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
             N++L++  L+     + VNAK   G + LH AA   +     D V LL++ GA P+  
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763

Query: 683 NLENEQPV 690
           + +   P+
Sbjct: 764 SSDGTTPL 771



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)

Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
           Q  +K  D  T LH A   G   +S +L   ++    +  K  NG S   +A   +    
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
           V+ L+   A+++       TPLHV A  GH +V + +  KGA  +++ ++       G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373

Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
           PLH A   ++  V EL          V E  L    +         +K L+Q GA+    
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           + K   T LH+AA   + E+ +  L+  +    VNAKA +  T LH AA    R+   + 
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
           V+LL+   A+P+        P+H+       E +  +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L N      LSK   G T LHIA       ++ +L   +N    ++    NG +   +A 
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
                ++V+ L++ GAQ+ T      TPLH  A  GH ++ + +       +    ++A 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
             +GL+P+H A    +    +  R    +  E+ ++ L + + +            K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
             GA   ++   +G T LH+A ++ ++ ++ L L+  +    ++A   +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
            +    L  V+ L+++GA P+  N++ E P+H+       E  + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA     H + + L++ GA+ N+    G TPLH+  +K H +V++ + K          +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397

Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
           +A    GLTPLH A  + H  +V   LQR   P+   V+      +       +  K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q  A V AK  K  +T LH AA   +  +++L LE     +  N     G+T LH+AA  
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             R   ++ V  L+ K A  +    +   P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
           + +  +E +  ++F  A  +       D +  G  +NT +  G   LH+ +++GH   V+
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62

Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
           + + K  +       LE T   G T LH A +A  + VV E                   
Sbjct: 63  ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96

Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
                    L+  GA V A+ +K G T L++AA+E +LE+++  LE
Sbjct: 97  ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A  +G   +   L  K     +L+     G +A  +A  A Q  +V++LVN GA VN
Sbjct: 49  LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
                G TPL++ A++ H +V++ + +   G+NQ V  E    DG TPL       H  V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159

Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           +AH              +H   RN    +  V   LL+N    D +              
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
            K+G T LH+AA   NL + +L L   + ++F      NG T LH+A+    R   +  V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255

Query: 670 RLLMRKGADPSTRNLENEQPVH 691
           RLL+ +GA   T+  +   P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S+  +G T LHIA  +    +  +L +   ++   D    +G +   VA       IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L+  GA  N ++    TPLH+ A  GH++V + + +     N      A   D  TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476

Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
           A  I H N V   L+ N  P+    +      +   +  V+T+  L++  A+ +A   K 
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LH+AA+   + +  L LE     +  NA   NG T LHVA         LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588

Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           + +G  P +       P+H+       E  R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           +G T LH+AV      +  +L  +  + H       NG +   +A   NQ  + + L+  
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
           G   N     G TPLH+ A++GH++++  +       N        N  GLTPLH     
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676

Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
                      Q+ H P V ++L+K+  +VD                 + G T LH+A+ 
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710

Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
             N++L++  L+     + VNAK   G + LH AA   +     D V LL++ GA P+  
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763

Query: 683 NLENEQPV 690
           + +   P+
Sbjct: 764 SSDGTTPL 771



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)

Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
           Q  +K  D  T LH A   G   +S +L   ++    +  K  NG S   +A   +    
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
           V+ L+   A+++       TPLHV A  GH +V + +  KGA  +++ ++       G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373

Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
           PLH A   ++  V EL          V E  L    +         +K L+Q GA+    
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           + K   T LH+AA   + E+ +  L+  +    VNAKA +  T LH AA    R+   + 
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
           V+LL+   A+P+        P+H+       E +  +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L N      LSK   G T LHIA       ++ +L   +N    ++    NG +   +A 
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
                ++V+ L++ GAQ+ T      TPLH  A  GH ++ + +       +    ++A 
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
             +GL+P+H A    +    +  R    +  E+ ++ L + + +            K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
             GA   ++   +G T LH+A ++ ++ ++ L L+  +    ++A   +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
            +    L  V+ L+++GA P+  N++ E P+H+       E  + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA     H + + L++ GA+ N+    G TPLH+  +K H +V++ + K          +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397

Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
           +A    GLTPLH A  + H  +V   LQR   P+   V+      +       +  K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q  A V AK  K  +T LH AA   +  +++L LE     +  N     G+T LH+AA  
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             R   ++ V  L+ K A  +    +   P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)

Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
           + +  +E +  ++F  A  +       D +  G  +NT +  G   LH+ +++GH   V+
Sbjct: 3   YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62

Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
           + + K  +       LE T   G T LH A +A  + VV E                   
Sbjct: 63  ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96

Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
                    L+  GA V A+ +K G T L++AA+E +LE+++  LE
Sbjct: 97  ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T LHIA   G   ++ +L  +  A+   D    NG +   VA       +V+ L++ G
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 268

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
            Q++     G TPLH  A  GH QV++  +++GA        L A   +GL+PLH A   
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 321

Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
                   ++ H A V +                        L +   P++  +      
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 381

Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
            +   K+ +  ++ L++ GA+++A   +SG T +H+AA   +L ++ L L+  +     N
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440

Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
            +   G TALH+AA    R  Q++ VR L+R GA    R  E + P+H+
Sbjct: 441 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 482



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S   +G T LH+A     + ++ +L  K  + H       NG +   +A   NQ  I   
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 626

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
           L+N GA+ N     G TPLH+ +++GH+  V   + KGA       ++  +   GLT LH
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 679

Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
            A       +A     H   ++          ++  +   V  +  L++ GA V AK  K
Sbjct: 680 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 738

Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
           +G T LH AA++ +  +I + L+     +  NA   NGNTAL +A  L Y ++ +D +++
Sbjct: 739 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 794

Query: 672 LMRKGADPSTRNLENEQ 688
           +  +    +T   E  +
Sbjct: 795 VTEEVTTTTTTITEKHK 811



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G+T LHIA   G+  +  VL ++   ++    +  NG +   +A   N   +V+ L+  G
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
           A  +T    G TPL V  ++GH+Q +  +          ++ +      L  LH A    
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 182

Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
           +     L   Q  H+ +VQ  ++ N++                V+    L+  GAAV+  
Sbjct: 183 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
            R +G T LH+A++  N  +++L L+       ++AK  +G T LH AA    R      
Sbjct: 242 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 293

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
           V LL+ +GA    R      P+H+   G   E ++ +L+ K+
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 335



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T +H+A   G   L+ VL    N     D+    G++A  +A  A Q  +V+ L+  G
Sbjct: 410 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 466

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
           A V+      +TPLH+ +  G ++++Q + +           +A   +G TPLH      
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 520

Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
                +V+      H L   ++  +P    +  K  SL D  K L+Q  AA ++   K+G
Sbjct: 521 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 575

Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
            T LH+AA   N ++  L LE  +     +A A NG T LH+AA    +  Q+     L+
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 628

Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
             GA+ +    +   P+HL       + +  +L KG +I
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)

Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
           K  +  S  + A A N   +V+ L   G  +NT +  G   LH+ A++GH  ++Q +   
Sbjct: 7   KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 62

Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
            +G    VD  +    G T LH A +A  A                           + +
Sbjct: 63  -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 92

Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
           K L++ GA + A+  ++G T L++AA+E ++++++  LE
Sbjct: 93  KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 130


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T LHIA   G   ++ +L  +  A+   D    NG +   VA       +V+ L++ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
            Q++     G TPLH  A  GH QV++  +++GA        L A   +GL+PLH A   
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342

Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
                   ++ H A V +                        L +   P++  +      
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402

Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
            +   K+ +  ++ L++ GA+++A   +SG T +H+AA   +L ++ L L+  +     N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461

Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
            +   G TALH+AA    R  Q++ VR L+R GA    R  E + P+H+
Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S   +G T LH+A     + ++ +L  K  + H       NG +   +A   NQ  I   
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
           L+N GA+ N     G TPLH+ +++GH+  V   + KGA       ++  +   GLT LH
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700

Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
            A       +A     H   ++          ++  +   V  +  L++ GA V AK  K
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759

Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
           +G T LH AA++ +  +I + L+     +  NA   NGNTAL +A  L Y ++ +D +++
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815

Query: 672 LMRKGADPSTRNLENEQ 688
           +  +    +T   E  +
Sbjct: 816 VTEEVTTTTTTITEKHK 832



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G+T LHIA   G+  +  VL ++   ++    +  NG +   +A   N   +V+ L+  G
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
           A  +T    G TPL V  ++GH+Q +  +          ++ +      L  LH A    
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203

Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
           +     L   Q  H+ +VQ  ++ N++                V+    L+  GAAV+  
Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
            R +G T LH+A++  N  +++L L+       ++AK  +G T LH AA    R      
Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
           V LL+ +GA    R      P+H+   G   E ++ +L+ K+
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T +H+A   G   L+ VL    N     D+    G++A  +A  A Q  +V+ L+  G
Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
           A V+      +TPLH+ +  G ++++Q + +           +A   +G TPLH      
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541

Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
                +V+      H L   ++  +P    +  K  SL D  K L+Q  AA ++   K+G
Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596

Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
            T LH+AA   N ++  L LE  +     +A A NG T LH+AA    +  Q+     L+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649

Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
             GA+ +    +   P+HL       + +  +L KG +I
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)

Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
           K  +  S  + A A N   +V+ L   G  +NT +  G   LH+ A++GH  ++Q +   
Sbjct: 28  KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83

Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
            +G    VD  +    G T LH A +A  A                           + +
Sbjct: 84  -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113

Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
           K L++ GA + A+  ++G T L++AA+E ++++++  LE
Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T LHIA   G   ++ +L  +  A+   D    NG +   VA       +V+ L++ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
            Q++     G TPLH  A  GH QV++  +++GA        L A   +GL+PLH A   
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342

Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
                   ++ H A V +                        L +   P++  +      
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402

Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
            +   K+ +  ++ L++ GA+++A   +SG T +H+AA   +L ++ L L+  +     N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461

Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
            +   G TALH+AA    R  Q++ VR L+R GA    R  E + P+H+
Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           S   +G T LH+A     + ++ +L  K  + H       NG +   +A   NQ  I   
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
           L+N GA+ N     G TPLH+ +++GH+  V   + KGA       ++  +   GLT LH
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700

Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
            A       +A     H   ++          ++  +   V  +  L++ GA V AK  K
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759

Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
           +G T LH AA++ +  +I + L+     +  NA   NGNTAL +A  L Y ++ +D +++
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815

Query: 672 LMRKGADPSTRNLENEQ 688
           +  +    +T   E  +
Sbjct: 816 VTEEVTTTTTTITEKHK 832



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G+T LHIA   G+  +  VL ++   ++    +  NG +   +A   N   +V+ L+  G
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
           A  +T    G TPL V  ++GH+Q +  +          ++ +      L  LH A    
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203

Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
           +     L   Q  H+ +VQ  ++ N++                V+    L+  GAAV+  
Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
            R +G T LH+A++  N  +++L L+       ++AK  +G T LH AA    R      
Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314

Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
           V LL+ +GA    R      P+H+   G   E ++ +L+ K+
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T +H+A   G   L+ VL    N     D+    G++A  +A  A Q  +V+ L+  G
Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
           A V+      +TPLH+ +  G ++++Q + +           +A   +G TPLH      
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541

Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
                +V+      H L   ++  +P    +  K  SL D  K L+Q  AA ++   K+G
Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596

Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
            T LH+AA   N ++  L LE  +     +A A NG T LH+AA    +  Q+     L+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649

Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
             GA+ +    +   P+HL       + +  +L KG +I
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)

Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
           K  +  S  + A A N   +V+ L   G  +NT +  G   LH+ A++GH  ++Q +   
Sbjct: 28  KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83

Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
            +G    VD  +    G T LH A +A  A                           + +
Sbjct: 84  -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113

Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
           K L++ GA + A+  ++G T L++AA+E ++++++  LE
Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 74/281 (26%), Positives = 127/281 (45%), Gaps = 23/281 (8%)

Query: 410 TTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGD---TFLHIAVAQGRRALSYVLARK 466
           TT+ G +      +  + ++AN+   +  S DA G    T LH+A     + ++ +L  +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620

Query: 467 MNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHS 526
             + H       NG +   +A   NQ  I   L+  GA  N     G   +H+ A++GH 
Sbjct: 621 GASPHAA---AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677

Query: 527 QVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 586
            ++  +    +G N  V+L  +N  GLTPLH A       V E+  NQ  H     ++  
Sbjct: 678 DMVSLL----LGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731

Query: 587 KNKSL------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 640
               +      +  +  L+Q  A V AK  K+G T LH AA++ +  +I + L+  +   
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNAS-- 788

Query: 641 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPST 681
             N    NGNTAL +A  L Y ++ +D ++++  +    +T
Sbjct: 789 -PNELTVNGNTALGIARRLGY-ISVVDTLKIVTEETMTTTT 827



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 71/255 (27%), Positives = 110/255 (43%), Gaps = 46/255 (18%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           +K  +G T LHIA  + R  +  +L +   ++  +     +G +   VA       IV  
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT---ESGLTPIHVAAFMGHVNIVSQ 451

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLH 557
           L++ GA  NTT+  G T LH+ A  G ++V++  +Q GA        +EA   D  TPLH
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-------QVEAKAKDDQTPLH 504

Query: 558 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
            +     A                           D ++ L+Q GA+  A    SG T L
Sbjct: 505 ISARLGKA---------------------------DIVQQLLQQGASPNAA-TTSGYTPL 536

Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
           HL+A E + ++    L+  + LS    K   G T LHVAA    +  +L+   LL++K A
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKK---GFTPLHVAA----KYGKLEVANLLLQKSA 589

Query: 678 DPSTRNLENEQPVHL 692
            P         P+H+
Sbjct: 590 SPDAAGKSGLTPLHV 604



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 72/279 (25%), Positives = 125/279 (44%), Gaps = 24/279 (8%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T LHIA   G   ++ +L   +N    +D    N  +   VA       +V+ L++ G
Sbjct: 235 GFTPLHIAAHYGNINVATLL---LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA- 562
           A+++     G TPLH  A  GH QV++ +   A        + +   +GL+PLH A    
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA------APILSKTKNGLSPLHMATQGD 345

Query: 563 HNAVVHELQRNQQPHSPEVQELL-----LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
           H   V  L ++  P      + L       +       K L+   A   AK   +G T L
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK-ALNGFTPL 404

Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
           H+A ++  ++++ L L+  +    + A   +G T +HVAA + +    ++ V  LM  GA
Sbjct: 405 HIACKKNRIKVMELLLKHGAS---IQAVTESGLTPIHVAAFMGH----VNIVSQLMHHGA 457

Query: 678 DPSTRNLENEQPVHLVPDGPVGEQIRRILK-GKSIQQRA 715
            P+T N+  E  +H+       E +R +++ G  ++ +A
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 71/282 (25%), Positives = 120/282 (42%), Gaps = 44/282 (15%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G+T LH+A   G+  +   L +       ++ K  + Q+   ++    +  IVQ L+  G
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGA---QVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKGAV--------GSNQFVD 544
           A  N     G TPLH+ A +GH  V   +           +KG          G  +  +
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 545 L--------EATNYDGLTPLHCAVIAHNAVVHELQRNQ--QPHSPEVQEL----LLKNKS 590
           L        +A    GLTPLH A    N  V  L  +Q   PH+          +   K+
Sbjct: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642

Query: 591 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
            +D    L++ GA   A  R+ G  ++HLAA+E +++++ L L      + VN    +G 
Sbjct: 643 QMDIATTLLEYGADANAVTRQ-GIASVHLAAQEGHVDMVSLLL---GRNANVNLSNKSGL 698

Query: 651 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
           T LH+AA    +  +++   +L+ +GA    +      P+H+
Sbjct: 699 TPLHLAA----QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 66/255 (25%), Positives = 109/255 (42%), Gaps = 23/255 (9%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T +H+A   G   +   L     + +  +++   G++A  +A  + Q  +V+ LV  G
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQDG 489

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 560
           AQV       +TPLH+ A  G + ++Q + +     N      A    G TPLH +    
Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN------AATTSGYTPLHLSAREG 543

Query: 561 ---IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
              +A   + H    +           +      ++    L+Q  A+ +A   KSG T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG-KSGLTPL 602

Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
           H+AA   N ++  L L+  +     +A A NG T LH+AA    +  Q+D    L+  GA
Sbjct: 603 HVAAHYDNQKVALLLLDQGAS---PHAAAKNGYTPLHIAA----KKNQMDIATTLLEYGA 655

Query: 678 DPSTRNLENEQPVHL 692
           D +    +    VHL
Sbjct: 656 DANAVTRQGIASVHL 670



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 73/304 (24%), Positives = 119/304 (39%), Gaps = 56/304 (18%)

Query: 424 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 483
           +++ K    S+D+    DA+             +AL Y+     N +  ++I   NG +A
Sbjct: 23  EKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYI----KNGVD-INICNQNGLNA 77

Query: 484 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 543
             +A       +V +L+   A V+     G T LH+ +  G ++V++ +       N   
Sbjct: 78  LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN--- 134

Query: 544 DLEATNYDGLTPLHCAVIA-HNAVVHELQRN-------------------QQPHSPEVQE 583
              A + +G TPL+ A    H  VV  L  N                   QQ H  +V  
Sbjct: 135 ---AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD-QVVS 190

Query: 584 LLLKN----------------KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLE 627
           LLL+N                K        L+Q     +  + KSG T LH+AA   N+ 
Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNIN 249

Query: 628 LIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENE 687
           +  L L   + + F    A N  T LHVA+    +    + V+LL+ +GA    +  +  
Sbjct: 250 VATLLLNRAAAVDFT---ARNDITPLHVAS----KRGNANMVKLLLDRGAKIDAKTRDGL 302

Query: 688 QPVH 691
            P+H
Sbjct: 303 TPLH 306


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 70/215 (32%), Positives = 100/215 (46%), Gaps = 25/215 (11%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           VA    Q   V  L+N GA+V  T   GRTPLH+ A KGH  V+Q + K         DL
Sbjct: 16  VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAG------CDL 68

Query: 546 EATNYDGLTPLHCAVIAHN-----AVVHE---LQRNQQPHSPEVQELLLKNKSLVDTIKC 597
           +  +    T LH A +  N     A++HE   L R  +  +  + E      S   + K 
Sbjct: 69  DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFS--QSAKL 126

Query: 598 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAA 657
           L++ GA V AK+ K+G TALHLA + ++ +  R+ L   S     N     G+T LHVAA
Sbjct: 127 LVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAA 182

Query: 658 SLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
               R   L  +RLL+        +N   +  +H+
Sbjct: 183 ----RYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 53/300 (17%)

Query: 424 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 483
           Q E+ +  I++   ++    G T LH+A  +G   +  +L   + A   LD+++   Q+A
Sbjct: 22  QTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQIL---LKAGCDLDVQDDGDQTA 78

Query: 484 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 543
              A       I+  L++ G  ++  D  G T LH  +  G SQ  + + K   G+N   
Sbjct: 79  LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK--AGAN--- 133

Query: 544 DLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGA 603
            + A N  G T LH A              Q  HS   + LLL               G+
Sbjct: 134 -VLAKNKAGNTALHLAC-------------QNSHSQSTRVLLL--------------AGS 165

Query: 604 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 663
             + K+  +G T LH+AA   +L +IRL L   +    V+ K   G+TALHVAA+L ++ 
Sbjct: 166 RADLKN-NAGDTCLHVAARYNHLSIIRLLL---TAFCSVHEKNQAGDTALHVAAALNHK- 220

Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPV-----HLVPDGPV----GEQIRRILKGKSIQQR 714
                 ++L+  GAD +  N   + P+     H  P+  +      Q+ R  +G+S++++
Sbjct: 221 ---KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKK 277



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 39/148 (26%), Positives = 61/148 (41%), Gaps = 9/148 (6%)

Query: 420 WQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN 479
           W    + +KL   +    L+K+  G+T LH+A        + VL   + A    D+K + 
Sbjct: 117 WHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL---LLAGSRADLKNNA 173

Query: 480 GQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGS 539
           G +   VA   N   I++ L+     V+  +  G T LHV A   H +V + + +     
Sbjct: 174 GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG--- 230

Query: 540 NQFVDLEATNYDGLTPLHCAVIAHNAVV 567
               D    N  G TPL  A   +N  V
Sbjct: 231 ---ADTTIVNNAGQTPLETARYHNNPEV 255


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 74/260 (28%), Positives = 121/260 (46%), Gaps = 27/260 (10%)

Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           D DG   LH A   G    + +L   ++    +D +E  G +   +A   N   + + LV
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLL---LDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
           +  A  N  +  G+TPLHV A  GH  +++ +      ++Q  +L+A   +  TPLH AV
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL------TSQGAELDAQQRNLRTPLHLAV 535

Query: 561 IAH--NAVVHELQRNQQPHSPE------VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
                 A+ H L+    P + +      +     + K L+   K L++ GA++E    + 
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI--CKMLLRYGASLELPTHQ- 592

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           G T LHLAA + +LE+I L  E  + +  + A  +   T LH+AA    R  +   V  L
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW---TPLHLAA----RHGEEAVVSAL 645

Query: 673 MRKGADPSTRNLENEQPVHL 692
           ++ GADP+        P+HL
Sbjct: 646 LQCGADPNAAEQSGWTPLHL 665



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 68/252 (26%), Positives = 112/252 (44%), Gaps = 29/252 (11%)

Query: 446 TFLHIAVAQGR-RALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGA 504
           T LH+AV +G+ RA+ ++L  K  A+   D  + +G      A A  ++LI + L+  GA
Sbjct: 529 TPLHLAVERGKVRAIQHLL--KSGAVP--DALDQSGYGPLHTAAARGKYLICKMLLRYGA 584

Query: 505 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV-IAH 563
            +      G TPLH+ A KGH +++  + +          L A N+   TPLH A     
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA---LGAVNW---TPLHLAARHGE 638

Query: 564 NAVVHE-LQRNQQPHSPEVQ-----ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
            AVV   LQ    P++ E        L ++  + +  I  L++  A V A++ K G T  
Sbjct: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN-LLEHHANVHARN-KVGWTPA 696

Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
           HLAA + N  ++++ +E  + L   +  +            LQ  L       +   +G 
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVS---------CTPLQLALRSRKQGIMSFLEGK 747

Query: 678 DPSTRNLENEQP 689
           +PS   L   +P
Sbjct: 748 EPSVATLGGSKP 759



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 20/203 (9%)

Query: 515 TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV------IAHNAVVH 568
           TPLH    +G  + ++ +    V      D++     G TPL  A       +    + H
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEV------DVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 569 ELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLEL 628
               N+                   T + L+  GA V+A++R+ G T LHLAA+     +
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENV 476

Query: 629 IRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQ 688
            RL   L S  +  N     G T LHVAA   +    +  V+LL  +GA+   +      
Sbjct: 477 ARL---LVSRQADPNLHEAEGKTPLHVAAYFGH----VSLVKLLTSQGAELDAQQRNLRT 529

Query: 689 PVHLVPDGPVGEQIRRILKGKSI 711
           P+HL  +      I+ +LK  ++
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAV 552


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 63/233 (27%), Positives = 109/233 (46%), Gaps = 44/233 (18%)

Query: 477 EHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQ-KG 535
           + + ++A   A +A    IV+ L+ +G  VN  D  G +PLH+ A  G  ++++A+  KG
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
           A        + A N +G TPLH A                            +K+  +  
Sbjct: 97  A-------QVNAVNQNGCTPLHYAA---------------------------SKNRHEIA 122

Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 655
             L++ GA  +AKD     TA+H AA + NL++I + L   +     N +   GNT LH+
Sbjct: 123 VMLLEGGANPDAKDHYEA-TAMHRAAAKGNLKMIHILLYYKAS---TNIQDTEGNTPLHL 178

Query: 656 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
           A   +    +++  +LL+ +GA     N E + P+  V  G +G  ++R+++G
Sbjct: 179 ACDEE----RVEEAKLLVSQGASIYIENKEEKTPLQ-VAKGGLGLILKRMVEG 226



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 4/191 (2%)

Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           D D  T LH A + G   +   L   +     ++ K+  G S   +A +A +  IV+ L+
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFL---LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
             GAQVN  +  G TPLH  A K   ++   + +G    +     EAT            
Sbjct: 94  GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLK 153

Query: 561 IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLA 620
           + H  + ++   N Q         L  ++  V+  K L+  GA++   + K  +T L +A
Sbjct: 154 MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI-ENKEEKTPLQVA 212

Query: 621 AEEANLELIRL 631
                L L R+
Sbjct: 213 KGGLGLILKRM 223


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 84/309 (27%), Positives = 127/309 (41%), Gaps = 38/309 (12%)

Query: 432 ISQDQFLSKDADG--DTFLHIAVAQGRR-ALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           ++ ++  S+D  G   T LH A   GR+  + Y+L    N    +  ++  G      A 
Sbjct: 44  VTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN----VQARDDGGLIPLHNAC 99

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEA 547
           +     +V  L+  GA  N  D W  TPLH  A KG   V +  +Q GA  + +  D   
Sbjct: 100 SFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTD-GR 158

Query: 548 TNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL---------------- 591
           T  D   P   AV+       EL  + +  + E    LL   ++                
Sbjct: 159 TALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLA 218

Query: 592 -----VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 646
                V  ++ L+Q GA V AKD K     LH A    + E+  L ++  +C   VNA  
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELLVKHGAC---VNAMD 274

Query: 647 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
               T LH AAS      +++   LL+  GADP+  N  N+  + L P   + E++    
Sbjct: 275 LWQFTPLHEAASKN----RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330

Query: 707 KGKSIQQRA 715
           KG S+ Q A
Sbjct: 331 KGHSLLQAA 339



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 88/320 (27%), Positives = 132/320 (41%), Gaps = 49/320 (15%)

Query: 403 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYV 462
           ++GN     QL ++     VE  + KL  +        +    T LH A    R ++   
Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVK-KLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 463 LARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAE 522
           L +    +H    K+  G      A +   + + + LV  GA VN  D W  TPLH  A 
Sbjct: 545 LLQHGADVHA---KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 523 KGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEV 581
           KG  ++ +  +Q GA       D    N DG TPL   V   +  + +L R         
Sbjct: 602 KGKYEICKLLLQHGA-------DPTKKNRDGNTPLD-LVKDGDTDIQDLLRGDAALLDAA 653

Query: 582 QELLL---KNKSLVDTIKC-------------------------LIQMGAAVEAKDRKSG 613
           ++  L   K  S  D + C                         L+Q GA V A+D K G
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQD-KGG 712

Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
              LH AA   ++++  L ++  +C++  +  A+   T LH AA  Q   TQL A  LL+
Sbjct: 713 LIPLHNAASYGHVDVAALLIKYNACVNATDKWAF---TPLHEAA--QKGRTQLCA--LLL 765

Query: 674 RKGADPSTRNLENEQPVHLV 693
             GADP+ +N E + P+ LV
Sbjct: 766 AHGADPTLKNQEGQTPLDLV 785



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 35/271 (12%)

Query: 446 TFLHIAVAQGRRALSYVLAR---KMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
           T LH+A  +    +  V+ +   K+NAL  L      GQ++   A         + L++ 
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNL------GQTSLHRAAYCGHLQTCRLLLSY 455

Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVD---LEATNYDGLTPLH-- 557
           G   N     G T L +    G+  V Q +Q+G    N   D   LEA     +  +   
Sbjct: 456 GCDPNIISLQGFTALQM----GNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511

Query: 558 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
           C V + N    E +++   H            + V  ++ L+Q GA V AKD K G   L
Sbjct: 512 CTVQSVNCRDIEGRQSTPLH-------FAAGYNRVSVVEYLLQHGADVHAKD-KGGLVPL 563

Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
           H A    + E+  L ++  + ++  +   +   T LH AA+      + +  +LL++ GA
Sbjct: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKF---TPLHEAAAKG----KYEICKLLLQHGA 616

Query: 678 DPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
           DP+ +N +   P+ LV DG     I+ +L+G
Sbjct: 617 DPTKKNRDGNTPLDLVKDGDT--DIQDLLRG 645



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 60/226 (26%), Positives = 99/226 (43%), Gaps = 25/226 (11%)

Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
           +A   N+  IVQ L+  GA V+  D     PLH     GH +V + + K     N     
Sbjct: 217 LAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN----- 271

Query: 546 EATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAV 605
            A +    TPLH A   +   V  L  +   +  +   L   NKS +D       +    
Sbjct: 272 -AMDLWQFTPLHEAASKNRVEVCSLLLS---YGADPTLLNCHNKSAID-------LAPTP 320

Query: 606 EAKDRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQY 661
           + K+R +    G + L  AA EA++  I+  L L   ++F + + +   TALH AA+  Y
Sbjct: 321 QLKERLAYEFKGHSLLQ-AAREADVTRIKKHLSL-EMVNFKHPQTHE--TALHCAAASPY 376

Query: 662 RLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
              +     LL+RKGA+ + +  E   P+H+  +    + +  ++K
Sbjct: 377 PKRK-QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 73/275 (26%), Positives = 118/275 (42%), Gaps = 28/275 (10%)

Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           D  G T LH A   G   +  +L  +   ++  D K+     A   A       +V+ LV
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR---AIHWAAYMGHIEVVKLLV 193

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
           + GA+V   D    TPLH  A  G   V++ +       +  VD+   N  G TPLH A 
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL------DLGVDMNEPNAYGNTPLHVAC 247

Query: 561 I-AHNAVVHEL--------QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
               + VV+EL        Q+N++  +P        + +L   ++ L+  GA V  K  K
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC--LELLVGNGADVNMKS-K 304

Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
            G+T LH+ A        +  ++  +    ++ +  NGNT LH+AA   + L     +  
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAV---IDCEDKNGNTPLHIAARYGHELL----INT 357

Query: 672 LMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
           L+  GAD + R +    P+HL       +  R++L
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 70/277 (25%), Positives = 125/277 (45%), Gaps = 24/277 (8%)

Query: 423 EQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDI--KEHNG 480
           + E  +L  +S  +  +KD+   T LH AVA        VL +     H  D+  ++ N 
Sbjct: 53  DAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-----HSADVNARDKNW 107

Query: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540
           Q+   +A A       + LV + + VN +D  GRT LH  A  GH ++++ +       N
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167

Query: 541 QF--VDLEATN---YDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
            F   D  A +   Y G   +   +++H A V    ++++ ++P        +  ++  +
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV--TCKDKKSYTP---LHAAASSGMISVV 222

Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 655
           K L+ +G  +  +    G T LH+A       ++    EL  C + VN K   G T LH 
Sbjct: 223 KYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN---ELIDCGAIVNQKNEKGFTPLHF 278

Query: 656 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
           AA+  +    L+   LL+  GAD + ++ + + P+H+
Sbjct: 279 AAASTHGALCLE---LLVGNGADVNMKSKDGKTPLHM 312



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 94/402 (23%), Positives = 154/402 (38%), Gaps = 87/402 (21%)

Query: 387 GHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKL---ANISQDQFLSKDAD 443
           GH  A +    SL   ++ N    T L  + F+  VE  +  +   A+I    ++ K   
Sbjct: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR-- 618

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
             T +H A   G      +L       + +DI++ NGQ+   ++V       V  L+N G
Sbjct: 619 --TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGA-------------------------- 536
           A V+  D WGRT LH  A  GH + + A +Q GA                          
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736

Query: 537 --VGSNQFVDLEATNYD--GLTPLHCAVIAHNAVVHELQRNQQ--------PHSPEVQEL 584
             + S   +D      D  G T LH A    +    EL   Q+          SP    +
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 585 LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNA 644
           +  N+   + +  +  +GA++       GRT LH AA   ++E ++L L   + ++ V++
Sbjct: 797 INDNEGAAEML--IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854

Query: 645 --------KAYNG-----------------------NTALHVAASLQYRLTQLDAVRLLM 673
                    A NG                       NTALH+A S  +  + L    L++
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSAL----LIL 910

Query: 674 RKGADPSTRNLEN---EQPVHLVPDGPVGEQIRRIL-KGKSI 711
            K  D +  N  N   + P+H+     +   ++ +L KG S+
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 23/259 (8%)

Query: 440 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDL 499
           K+  G T LH A A    AL   L     A   +++K  +G++   +     +    Q +
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGA--DVNMKSKDGKTPLHMTALHGRFSRSQTI 325

Query: 500 VNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGAVGSNQFVDLEATNYDGLTPLHC 558
           +  GA ++  D  G TPLH+ A  GH  ++   I  GA       D       G+ PLH 
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA-------DTAKRGIHGMFPLHL 378

Query: 559 AVIA--HNAVVHELQRNQQPHSP-EVQELLLKNKSLVDTIKC---LIQMGAAVEAKDRKS 612
           A ++   +     L       +P +     L   +    ++C   L+  GA    KD K 
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD-KF 437

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           GR+ LH AA   N +   LF  + S  S VN     G T LH AA+     T    +  L
Sbjct: 438 GRSPLHYAAANCNYQC--LFALVGSGAS-VNDLDERGCTPLHYAATSD---TDGKCLEYL 491

Query: 673 MRKGADPSTRNLENEQPVH 691
           +R  A+P  R+ +    VH
Sbjct: 492 LRNDANPGIRDKQGYNAVH 510



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 30/207 (14%)

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 555
           V+ L+     VN  D   RTPLH  A  G +++++ +       N      A +   LTP
Sbjct: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN------AKDSKWLTP 77

Query: 556 LHCAV-----------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA 604
           LH AV           + H+A V+   +N Q        +   NK+ V   + L+ + + 
Sbjct: 78  LHRAVASCSEEAVQVLLKHSADVNARDKNWQ----TPLHIAAANKA-VKCAEALVPLLSN 132

Query: 605 VEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLT 664
           V   DR +GRTALH AA   + E+++L L   S  + +NA       A+H AA + +   
Sbjct: 133 VNVSDR-AGRTALHHAAFSGHGEMVKLLL---SRGANINAFDKKDRRAIHWAAYMGH--- 185

Query: 665 QLDAVRLLMRKGADPSTRNLENEQPVH 691
            ++ V+LL+  GA+ + ++ ++  P+H
Sbjct: 186 -IEVVKLLVSHGAEVTCKDKKSYTPLH 211



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 56/237 (23%), Positives = 99/237 (41%), Gaps = 42/237 (17%)

Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
           ++ +++  ++    A       I++ L+  GA+VN  D    TPLH        + +Q +
Sbjct: 34  VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93

Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
            K +       D+ A + +  TPLH A             N+     E    LL N ++ 
Sbjct: 94  LKHS------ADVNARDKNWQTPLHIAA-----------ANKAVKCAEALVPLLSNVNVS 136

Query: 593 D-----------------TIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLEL 635
           D                  +K L+  GA + A D+K  R A+H AA   ++E+++L +  
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD-RRAIHWAAYMGHIEVVKLLVSH 195

Query: 636 PSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
            + ++  + K+Y   T LH AAS       +  V+ L+  G D +  N     P+H+
Sbjct: 196 GAEVTCKDKKSY---TPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 38/288 (13%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A   G    S    + +++   +D  +  G++    A A      +  L+N GA  N
Sbjct: 376 LHLAALSG---FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432

Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV-DLEATNYDGLTPLHCAVIAH--- 563
             D +GR+PLH  A   + Q L A+    VGS   V DL+     G TPLH A  +    
Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFAL----VGSGASVNDLDER---GCTPLHYAATSDTDG 485

Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA---------------VEAK 608
             + + L+ +  P   + Q     + S     +  +Q+ A+               +   
Sbjct: 486 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDS 545

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           D ++  + LHLAA   + + + + ++    L  ++ +  +G T L +AA   +    ++ 
Sbjct: 546 DNRATISPLHLAAYHGHHQALEVLVQ---SLLDLDVRNSSGRTPLDLAAFKGH----VEC 598

Query: 669 VRLLMRKGADPSTRN-LENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 715
           V +L+ +GA    ++ +    P+H        E + R+L G +  Q A
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECL-RLLIGNAEPQNA 645



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 23/93 (24%), Positives = 44/93 (47%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           L + +  +   +D   +T LH+A ++G    + ++  K+   ++++      Q+   VA 
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCA 521
                ++VQ+L+  GA V   D  G TP   CA
Sbjct: 935 RNGLTMVVQELLGKGASVLAVDENGYTPALACA 967


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 108/421 (25%), Positives = 157/421 (37%), Gaps = 92/421 (21%)

Query: 314 PIPPQSPAYEPNLFDGPESQFCPNQSLVSLLG--DQRESENIANPMQTSSSVQQQNDAHL 371
           P  P+S      L       F  + SL  LL   D   S+ +  P + S S  +      
Sbjct: 306 PPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSE------ 359

Query: 372 HSFSMMPSSACEAMVGHEMASDS---SNTSLPFSNMGNPMNTTQLG------KSLFQWQV 422
              S +PSS     +    + DS   S  SL  S    P +T+ LG      K L    V
Sbjct: 360 ---SKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP-STSDLGTTDVQKKKLVDAIV 415

Query: 423 EQEESKLANISQDQFLSKDAD-GDTFLHIAVAQGRRALSYVLA-----------RKMNAL 470
             + SKL  I Q Q +    D G + LH+AV  G+   +  L            R    L
Sbjct: 416 SGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475

Query: 471 HM-------------------LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDC 511
           HM                   ++ K+ +  +A   A         + L+   A VN  D 
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535

Query: 512 WGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQ 571
            GRTP+HV  + G   +++ + +      + VD+     D   PLH A            
Sbjct: 536 EGRTPMHVACQHGQENIVRILLR------RGVDVSLQGKDAWLPLHYAA----------- 578

Query: 572 RNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 631
              Q H P + +LL K            Q G +V A+    GRT LHLAA+  +  + R+
Sbjct: 579 --WQGHLP-IVKLLAK------------QPGVSVNAQ-TLDGRTPLHLAAQRGHYRVARI 622

Query: 632 FLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVH 691
            ++L    S VN  +    T LHVAA   +  T     RLL+ +GA       +    +H
Sbjct: 623 LIDL---CSDVNVCSLLAQTPLHVAAETGHTST----ARLLLHRGAGKEAMTSDGYTALH 675

Query: 692 L 692
           L
Sbjct: 676 L 676



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 74/267 (27%), Positives = 116/267 (43%), Gaps = 25/267 (9%)

Query: 403 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLS---KDADGDTFLHIAVAQGRRAL 459
           N  NP  + + G +     VE+    +  +   + +S   KD D  T LH A   G  + 
Sbjct: 460 NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESS 519

Query: 460 SYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTT--DCWGRTPL 517
           + +L  K  +++ +D +   G++   VA    Q  IV+ L+  G  V+    D W   PL
Sbjct: 520 TRLLLEKNASVNEVDFE---GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW--LPL 574

Query: 518 HVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN----AVVHELQRN 573
           H  A +GH  +++ + K        V + A   DG TPLH A    +     ++ +L  +
Sbjct: 575 HYAAWQGHLPIVKLLAK-----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629

Query: 574 QQPHSPEVQELL--LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 631
               S   Q  L          T + L+  GA  EA     G TALHLAA   +L  ++L
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT-SDGYTALHLAARNGHLATVKL 688

Query: 632 FLELPSCLSFVNAKAYNGNTALHVAAS 658
            +E     + V A+     TALH+AA+
Sbjct: 689 LVEEK---ADVLARGPLNQTALHLAAA 712



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 12/121 (9%)

Query: 446 TFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI-VQDLVNIGA 504
           T LH+A   G  + + +L  +      +     +G +A  +A A N HL  V+ LV   A
Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMT---SDGYTALHLA-ARNGHLATVKLLVEEKA 694

Query: 505 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN 564
            V       +T LH+ A  GHS+V++ +    V       ++  +  GL+ LH A    +
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-------IDLFDEQGLSALHLAAQGRH 747

Query: 565 A 565
           A
Sbjct: 748 A 748


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 80/290 (27%), Positives = 126/290 (43%), Gaps = 49/290 (16%)

Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
           ++D    T LH+A A      +  LA  +++L++ D    +G+SA   AV +     V  
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD---RSGRSALHHAVHSGHLETVNL 158

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKG------AVGSNQ 541
           L+N GA +N  D   R PLH  A  GH +VL+ +           +KG      A  S Q
Sbjct: 159 LLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ 218

Query: 542 F----------VDLEATNYDGLTPLHCA-VIAHNAVVHEL--------QRNQQPHSPEVQ 582
                       +++  N  G T LH A  +  +AV  EL        Q N +  +P   
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278

Query: 583 ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFV 642
             +  N +L   ++ L+  GA V  +  K G++ LH+AA        ++ ++     S +
Sbjct: 279 AAVSTNGAL--CLELLVNNGADVNYQS-KEGKSPLHMAAIHGRFTRSQILIQNG---SEI 332

Query: 643 NAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
           +     GNT LHVAA   + L     +  LM  GAD + R + +  P+HL
Sbjct: 333 DCADKFGNTPLHVAARYGHEL----LISTLMTNGADTARRGIHDMFPLHL 378



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 70/261 (26%), Positives = 114/261 (43%), Gaps = 23/261 (8%)

Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           DA G T L +A+  G     ++L  K +     D++   G++A            +  L+
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR---GRTALHRGAVTGCEDCLAALL 741

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEA-TNYDGLTPLHCA 559
           +  A V   D  GRTP+H+ +  GH+ VL+ + + A+ ++    L+A  +Y G +P+H A
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD---PLDAGVDYSGYSPMHWA 798

Query: 560 VIAHNAVVHELQRNQQPHS-------PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
               +    EL     P S         +   ++ N+    T   L  +GA +       
Sbjct: 799 SYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDST-TEMLLGALGAKIVNSRDAK 857

Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
           GRT LH AA   N+  +R+ L+     + VNA  + G TAL  AA       Q  AV  L
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQ---AEVNATDHTGRTALMTAA----ENGQTAAVEFL 910

Query: 673 MRKG-ADPSTRNLENEQPVHL 692
           + +G AD +  +      +HL
Sbjct: 911 LYRGKADLTVLDENKNTALHL 931



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 45/235 (19%)

Query: 448 LHIAVAQG-----RRALS----YVLARKMNALHML------DIKEHNGQSAFQVAVAANQ 492
           LH+AV  G     R+ LS    Y +   ++  H+L      +  ++ G++    A +   
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435

Query: 493 HLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDG 552
              +  L++ GA +   D +GRTPLH  A  G  Q    +     G N+       +  G
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE------ADCKG 489

Query: 553 LTPLHCAVIAHNAVVHELQRNQQPHSP-----EVQELL--LKNKSLVDTIKCLIQMGAAV 605
            +PLH A  +      +  R  +PH+P     E  E L   + K     ++ L+  GA  
Sbjct: 490 CSPLHYAAAS------DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP 543

Query: 606 EAKDRKSGRTALHLAAEEANLELIRLFLELP-SCLSFVNA---------KAYNGN 650
             +DR+ G TA+H AA   N + + L LE+  +CL  V +          AYNG+
Sbjct: 544 SLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 77/300 (25%), Positives = 123/300 (41%), Gaps = 53/300 (17%)

Query: 413 LGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHM 472
           L +++F   VE+  S L+       L  D +  T LH A   G   +  +L   M+  ++
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVL--DQERRTPLHAAAYVGDVPILQLLL--MSGANV 67

Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
            + K+    +    A A+    ++  L+   A VN  D   +TPLHV A    ++  +A+
Sbjct: 68  -NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126

Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL- 591
                 +     L   +  G + LH AV                H   V  LL K  SL 
Sbjct: 127 ------APLLSSLNVADRSGRSALHHAV-------------HSGHLETVNLLLNKGASLN 167

Query: 592 ------------------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFL 633
                             ++ +K L+  GA +  KDRK G   LH AA    +E+++  L
Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK-GYGLLHTAAASGQIEVVKYLL 226

Query: 634 ELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL-LMRKGADPSTRNLENEQPVHL 692
            + + +   NA    GNTALH+A  L       DAV + L+  GA+ +  N +   P+H+
Sbjct: 227 RMGAEIDEPNA---FGNTALHIACYLGQ-----DAVAIELVNAGANVNQPNDKGFTPLHV 278



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 20/218 (9%)

Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 555
           V+ L++    +N  D   RTPLH  A  G   +LQ +       N      A +   LTP
Sbjct: 24  VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN------AKDTLWLTP 77

Query: 556 LHCAVIAHNAVV------HELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
           LH A  + N  V      H    N +    +    +          + L  + +++   D
Sbjct: 78  LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137

Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
           R SGR+ALH A    +LE + L L   + L+  + K       LH AA L +    L+ +
Sbjct: 138 R-SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE---RQPLHWAAFLGH----LEVL 189

Query: 670 RLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
           +LL+ +GAD   ++ +    +H        E ++ +L+
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 70/296 (23%), Positives = 108/296 (36%), Gaps = 60/296 (20%)

Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
           G T LH+A      AL   L     A      KE  G+S   +A    +    Q L+  G
Sbjct: 272 GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE--GKSPLHMAAIHGRFTRSQILIQNG 329

Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 560
           ++++  D +G TPLHV A  GH  ++  +           D        + PLH AV   
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGA------DTARRGIHDMFPLHLAVLFG 383

Query: 561 -----------------IAHNAVVHELQRNQQPHSPE-VQELLLKNKSLVDTIKCL---I 599
                            ++  +  H L      ++P+ +    L   +    ++CL   +
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH-VAAS 658
             GA +  +D K GRT LH AA   + +     + L +  + VN     G + LH  AAS
Sbjct: 444 SSGADLRRRD-KFGRTPLHYAAANGSYQCA---VTLVTAGAGVNEADCKGCSPLHYAAAS 499

Query: 659 LQYRLTQ-----------------------LDAVRLLMRKGADPSTRNLENEQPVH 691
             YR  +                          +  L+  GADPS R+ +    VH
Sbjct: 500 DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 17/219 (7%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH+A   G       LA     L  LD+++H G++A  +A        V+ L   GA   
Sbjct: 589 LHLAAYNGHCEALKTLAE---TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645

Query: 508 TTDCWGR-TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL-EATNYDGLTPLHCAVI-AHN 564
             +   + TPLH  A  GH+  L  +    + S +  D+ +  +  G TPL  A++  H 
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLL----IDSGERADITDVMDAYGQTPLMLAIMNGHV 701

Query: 565 AVVH-ELQRNQQPHSPEVQELLLKNKSLV----DTIKCLIQMGAAVEAKDRKSGRTALHL 619
             VH  L++     + +++     ++  V    D +  L+   A V  +D K GRT +HL
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFK-GRTPIHL 760

Query: 620 AAEEANLELIRLFLELPSCLSFVNAKA-YNGNTALHVAA 657
           A+   +  ++R  L+       ++A   Y+G + +H A+
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 18/201 (8%)

Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
           L++ GA  +  D  G T +H  A  G+ Q L+ + +  +  N   D+E+T    ++PLH 
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE--MSFNCLEDVESTI--PVSPLHL 591

Query: 559 AVIAHNAVVHELQR--------NQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 610
           A  A+N     L+         + + H       L   +   + ++ L   GA+   K+R
Sbjct: 592 A--AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649

Query: 611 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 670
           K   T LH AA   + + + L ++        +     G T L +A    +    +D V 
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH----VDCVH 705

Query: 671 LLMRKGADPSTRNLENEQPVH 691
           LL+ KG+     +L     +H
Sbjct: 706 LLLEKGSTADAADLRGRTALH 726



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 69/291 (23%), Positives = 116/291 (39%), Gaps = 18/291 (6%)

Query: 425  EESKLANISQDQF-LSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIK-EHNGQS 482
            E+   A +  D F L +D  G T +H+A A G  A+   L +   +   LD   +++G S
Sbjct: 734  EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793

Query: 483  AFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQF 542
                A +   H    +L+   +  +  +    TPLH CA   +      +  GA+G+   
Sbjct: 794  PMHWA-SYTGHEDCLELLLEHSPFSYLEGNPFTPLH-CAVINNQDSTTEMLLGALGAKIV 851

Query: 543  VDLEATNYDGLTPLHCAVIAHNA------VVHELQRNQQPHSPEVQELLLKNKSLVDTIK 596
               +A    G TPLH A  A N       + H+ + N   H+     +          ++
Sbjct: 852  NSRDAK---GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908

Query: 597  CLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA 656
             L+  G A      ++  TALHLA  + + +   + L     L  +NA     N+AL + 
Sbjct: 909  FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT----NSALQMP 964

Query: 657  ASLQYRLTQLDAVRLLMRKGADPSTRNLENEQP-VHLVPDGPVGEQIRRIL 706
              +  R      V+ L+  GA     + E   P +   P+  V + +  IL
Sbjct: 965  LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 77/296 (26%), Positives = 123/296 (41%), Gaps = 50/296 (16%)

Query: 440 KDADG--DTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQ 497
           +D +G   T LH A    R ++   L      +H    K+  G      A +   + + +
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA---KDKGGLVPLHNACSYGHYEVAE 734

Query: 498 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
            LV  GA VN  D W  TPLH  A KG  ++ + + K         D    N DG TPL 
Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGA------DPTKKNRDGNTPLD 788

Query: 558 CAV------------------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV------- 592
                                 A    +  +Q+   P +   ++   +N + +       
Sbjct: 789 LVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYN 848

Query: 593 --DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
             +  + L++ GA V A+D K G   LH AA   ++++  L ++  +C++  +  A+   
Sbjct: 849 NLEVAEYLLEHGADVNAQD-KGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAF--- 904

Query: 651 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
           T LH AA  Q   TQL A  LL+  GADP+ +N E + P+ L       + IR +L
Sbjct: 905 TPLHEAA--QKGRTQLCA--LLLAHGADPTMKNQEGQTPLDLA----TADDIRALL 952



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 83/296 (28%), Positives = 119/296 (40%), Gaps = 46/296 (15%)

Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
           LH A   GR+ +   L +    +H  D     G      A +     +V  L+  GA  N
Sbjct: 220 LHFAAGFGRKDVVEHLLQMGANVHARD---DGGLIPLHNACSFGHAEVVSLLLCQGADPN 276

Query: 508 TTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAV 566
             D W  TPLH  A KG   V +  +Q GA       D    N DG + L  A  +  AV
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-------DPNIRNTDGKSALDLADPSAKAV 329

Query: 567 V-------HELQRNQQPHSPEVQELLL------------KNKSL--------VDTIKCLI 599
           +         L+  +  +  ++  LL             K+  L        V  ++ L+
Sbjct: 330 LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLL 389

Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
           Q GA V AKD K G   LH A    + E+  L L+  +C   VNA      T LH AAS 
Sbjct: 390 QHGADVHAKD-KGGLVPLHNACSYGHYEVTELLLKHGAC---VNAMDLWQFTPLHEAASK 445

Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 715
                +++   LL+  GADP+  N   +  V + P   + E++    KG S+ Q A
Sbjct: 446 N----RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAA 497



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 79/332 (23%), Positives = 136/332 (40%), Gaps = 55/332 (16%)

Query: 414 GKSLFQWQVEQEESKLANISQDQFLS--KDADGDTFLHIAVAQ---GRRALSYVLARKMN 468
           G SL Q   E + +K+      + ++  +    +T LH AVA     R+ ++ +L RK  
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549

Query: 469 ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV 528
            ++    K  +  +   VA     + +++ L   GA++N  D  G+T LH  A  GH Q 
Sbjct: 550 NVNE---KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT 606

Query: 529 LQ------------------AIQKGAVGSNQFVD--------------LEATNYDGLTPL 556
            +                  A Q G     Q +               LEA+    L  +
Sbjct: 607 CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETV 666

Query: 557 HCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTA 616
                + N    +L+     HS  +      N+  V  ++ L+  GA V AKD K G   
Sbjct: 667 KQLCSSQNVNCRDLEGR---HSTPLHFAAGYNR--VSVVEYLLHHGADVHAKD-KGGLVP 720

Query: 617 LHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKG 676
           LH A    + E+  L +   + ++  +   +   T LH AA+      + +  +LL++ G
Sbjct: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKF---TPLHEAAA----KGKYEICKLLLKHG 773

Query: 677 ADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
           ADP+ +N +   P+ LV +G     I+ +L+G
Sbjct: 774 ADPTKKNRDGNTPLDLVKEGDT--DIQDLLRG 803



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 74/272 (27%), Positives = 116/272 (42%), Gaps = 30/272 (11%)

Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
           LA+ S    L+ +   D  L  A +     L  +L       H  D ++    +   +A 
Sbjct: 321 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRK---STPLHLAA 377

Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
             N+  IVQ L+  GA V+  D  G  PLH     GH +V + + K     N      A 
Sbjct: 378 GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN------AM 431

Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAK 608
           +    TPLH A   +   V  L  +   H  +   +    KS VD       M    E +
Sbjct: 432 DLWQFTPLHEAASKNRVEVCSLLLS---HGADPTLVNCHGKSAVD-------MAPTPELR 481

Query: 609 DRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA-ASLQYRL 663
           +R +    G + L  AA EA+L  ++  L L   ++F   +++   TALH A ASL  + 
Sbjct: 482 ERLTYEFKGHSLLQ-AAREADLAKVKKTLAL-EIINFKQPQSH--ETALHCAVASLHPKR 537

Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695
            Q+    LL+RKGA+ + +N +   P+H+  +
Sbjct: 538 KQV--TELLLRKGANVNEKNKDFMTPLHVAAE 567



 Score = 30.0 bits (66), Expect = 7.8
 Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 5/88 (5%)

Query: 42  AAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQP----V 97
           AAAP     S S     AP   GS S++  S+SS  +  +  S S  G+     P    V
Sbjct: 100 AAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGV 159

Query: 98  EPHMGVGRQQRGPFQGV-RVKNSVKELL 124
                +G    GP  GV  V  +++ELL
Sbjct: 160 SSTAPLGPGAAGPGTGVPAVSGALRELL 187


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 81/257 (31%), Positives = 108/257 (42%), Gaps = 33/257 (12%)

Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALH--MLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           DG T LH A  +G      VLA  M  L    LD  +  G++AF  A    Q   +  LV
Sbjct: 123 DGLTLLHCAAQKGHVP---VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLV 179

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
             G   N  D  G T LH+ A +GH  VLQ +    +G    +DLE  N +GLT LH A 
Sbjct: 180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD--IG----LDLEEQNAEGLTALHSAA 233

Query: 561 -IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV---------DTIKCLIQMGAAVEAKDR 610
             +H   V  L R        V  L  KN S +         D  + LI  G      D 
Sbjct: 234 GGSHPDCVQLLLR----AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDH 289

Query: 611 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 670
           + G + LHLA       L+RL +      S VNA      T LH+AA   ++    D   
Sbjct: 290 Q-GASPLHLAVRHNFPALVRLLINSD---SDVNAVDNRQQTPLHLAAEHAWQ----DIAD 341

Query: 671 LLMRKGADPSTRNLENE 687
           +L+  G D + R+ + +
Sbjct: 342 MLLIAGVDLNLRDKQGK 358



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 67/263 (25%), Positives = 111/263 (42%), Gaps = 37/263 (14%)

Query: 448 LHIAVAQGRRA-LSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQV 506
           LH A  Q     +  ++ R++N       + H G+ A   A  A     V+ L+   A V
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTR----ARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74

Query: 507 NTTD----------CWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL 556
           +  D          C+G   L + A  GH ++LQ +       N    +   + DGLT L
Sbjct: 75  DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL------VNSGAKIHCESKDGLTLL 128

Query: 557 HCAVIAHNA-----VVHELQRNQQPHSPEVQELLLKNKS---LVDTIKCLIQMGAAVEAK 608
           HCA    +      ++ +L+     H  ++        +    +D +  L+  G     K
Sbjct: 129 HCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188

Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
           D K G TALHLAA   ++ +++  +++   L   NA+   G TALH AA   +     D 
Sbjct: 189 D-KEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE---GLTALHSAAGGSHP----DC 240

Query: 669 VRLLMRKGADPSTRNLENEQPVH 691
           V+LL+R G+  +    +N   +H
Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLH 263



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 55/204 (26%), Positives = 89/204 (43%), Gaps = 22/204 (10%)

Query: 440 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN--GQSAFQVAVAANQHLIVQ 497
           KD +G+T LH+A  +G  A   VL R ++    LD++E N  G +A   A   +    VQ
Sbjct: 188 KDKEGNTALHLAAGRGHMA---VLQRLVDI--GLDLEEQNAEGLTALHSAAGGSHPDCVQ 242

Query: 498 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
            L+  G+ VN       + LH  A  G   V + +      +N        ++ G +PLH
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN------VVDHQGASPLH 296

Query: 558 CAVIAHN--AVVHEL-----QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 610
            AV  HN  A+V  L       N   +  +    L    +  D    L+  G  +  +D 
Sbjct: 297 LAV-RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRD- 354

Query: 611 KSGRTALHLAAEEANLELIRLFLE 634
           K G+TAL +A    ++ L+ + ++
Sbjct: 355 KQGKTALAVAVRSNHVSLVDMIIK 378



 Score = 37.7 bits (86), Expect = 0.037
 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 6/98 (6%)

Query: 595 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH 654
           ++ L+  GA +  +  K G T LH AA++ ++ ++   +E    ++  +     G TA H
Sbjct: 107 LQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKL-GRTAFH 164

Query: 655 VAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
            AA       QLDA+  L+  G D + ++ E    +HL
Sbjct: 165 RAAEHG----QLDALDFLVGSGCDHNVKDKEGNTALHL 198


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 64/241 (26%), Positives = 98/241 (40%), Gaps = 42/241 (17%)

Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
           LD+K+ +G+ A  VA       + Q L + G+  N  D    TPLH  A  G+  V +A+
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497

Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
            +     N        N +G TPL                           L    +   
Sbjct: 498 CEAGCNVN------IKNREGETPL---------------------------LTASARGYH 524

Query: 593 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 652
           D ++CL + GA + A D K G  ALHLA     +E+I+  L    C  FV+ +  +GNT 
Sbjct: 525 DIVECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLS-QGC--FVDYQDRHGNTP 580

Query: 653 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRI-LKGKSI 711
           LHVA     +   +  V  L     +    N     P+HL  +  + + +R + L G S+
Sbjct: 581 LHVAC----KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASV 636

Query: 712 Q 712
           +
Sbjct: 637 E 637



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%)

Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
           D DG   LH+AV   RR    V+   ++    +D ++ +G +   VA       IV  L 
Sbjct: 541 DKDGHIALHLAV---RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALC 597

Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 530
                ++ ++ +GRTPLH+ A  G   V++
Sbjct: 598 EANCNLDISNKYGRTPLHLAANNGILDVVR 627


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 66/229 (28%), Positives = 100/229 (43%), Gaps = 24/229 (10%)

Query: 472 MLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA 531
           +LD    +G SA   A       +V+ LV  GA VN  D  G TPLHV A  G+  + + 
Sbjct: 93  VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152

Query: 532 IQK-----GAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 586
           +        AV S+  + L+    D +  L  A IA   V  E  +  +      +ELLL
Sbjct: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE------EELLL 206

Query: 587 KNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 646
            +       +C +  GA  EA+  ++G +ALH+AA +  +E++RL L+        +   
Sbjct: 207 HDT------RCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDG-- 258

Query: 647 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695
            +G T LH AA         DA RLL   G    +     ++P  L  +
Sbjct: 259 -DGWTPLHAAAHWGVE----DACRLLAEHGGGMDSLTHAGQRPCDLADE 302



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 7/89 (7%)

Query: 604 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 663
           AV       G +ALH A  + NLE++R  +E  +    VN     G T LHVAAS  Y  
Sbjct: 92  AVLDSTNADGISALHQACIDENLEVVRFLVEQGAT---VNQADNEGWTPLHVAASCGY-- 146

Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPVHL 692
             LD  R L+  GA+ +  N + + P+ L
Sbjct: 147 --LDIARYLLSHGANIAAVNSDGDLPLDL 173


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,000,455
Number of Sequences: 37866
Number of extensions: 1483114
Number of successful extensions: 7292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 5180
Number of HSP's gapped (non-prelim): 1274
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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