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Search of human proteins with 13899229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13899229 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, zeta isoform a [Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13899229 nuclear factor of kappa light polypeptide gene enhan... 1444 0.0
gi|53832024 nuclear factor of kappa light polypeptide gene enhan... 1244 0.0
gi|41281709 nuclear factor of kappa light polypeptide gene enhan... 206 8e-53
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 113 7e-25
gi|117320531 nuclear factor of kappa light polypeptide gene enha... 101 3e-21
gi|117320540 nuclear factor of kappa light polypeptide gene enha... 101 3e-21
gi|117320527 nuclear factor of kappa light polypeptide gene enha... 101 3e-21
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 94 3e-19
gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 91 4e-18
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 89 1e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 82 2e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 82 2e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 82 2e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 82 2e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 82 2e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 79 1e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 79 1e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 79 1e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 77 6e-14
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 76 9e-14
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 75 2e-13
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 74 4e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 72 1e-12
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 71 3e-12
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 71 3e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 69 1e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 69 2e-11
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 68 3e-11
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 67 4e-11
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 67 6e-11
>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform a [Homo sapiens]
Length = 718
Score = 1444 bits (3739), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP 60
MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP
Sbjct: 1 MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAP 60
Query: 61 GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV 120
GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV
Sbjct: 61 GSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSV 120
Query: 121 KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP 180
KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP
Sbjct: 121 KELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRP 180
Query: 181 ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL 240
ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL
Sbjct: 181 ALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWL 240
Query: 241 NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP 300
NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP
Sbjct: 241 NPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQP 300
Query: 301 HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS 360
HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS
Sbjct: 301 HYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTS 360
Query: 361 SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW 420
SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW
Sbjct: 361 SSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQW 420
Query: 421 QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG 480
QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG
Sbjct: 421 QVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNG 480
Query: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540
QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN
Sbjct: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540
Query: 541 QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ 600
QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ
Sbjct: 541 QFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQ 600
Query: 601 MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ 660
MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ
Sbjct: 601 MGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQ 660
Query: 661 YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY 718
YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
Sbjct: 661 YRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY 718
>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform b [Homo sapiens]
Length = 618
Score = 1244 bits (3219), Expect = 0.0
Identities = 618/618 (100%), Positives = 618/618 (100%)
Query: 101 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 160
MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS
Sbjct: 1 MGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS 60
Query: 161 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 220
YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI
Sbjct: 61 YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNI 120
Query: 221 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 280
INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM
Sbjct: 121 INIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQM 180
Query: 281 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 340
IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL
Sbjct: 181 IDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSL 240
Query: 341 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 400
VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP
Sbjct: 241 VSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLP 300
Query: 401 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 460
FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS
Sbjct: 301 FSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALS 360
Query: 461 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 520
YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC
Sbjct: 361 YVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC 420
Query: 521 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 580
AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE
Sbjct: 421 AEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPE 480
Query: 581 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 640
VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS
Sbjct: 481 VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 540
Query: 641 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE
Sbjct: 541 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 600
Query: 701 QIRRILKGKSIQQRAPPY 718
QIRRILKGKSIQQRAPPY
Sbjct: 601 QIRRILKGKSIQQRAPPY 618
>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, delta [Homo sapiens]
Length = 313
Score = 206 bits (523), Expect = 8e-53
Identities = 126/298 (42%), Positives = 178/298 (59%), Gaps = 17/298 (5%)
Query: 422 VEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQ 481
+E + + + Q L++D +GDT LH+ A+G R +Y A + LDI+EH G+
Sbjct: 27 LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86
Query: 482 SAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQ 541
+ VA AANQ LIV+DL+N+GA+ N D GR+ LHV A G VL A+ + S
Sbjct: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV----LNSGV 142
Query: 542 FVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM 601
VDLEA +++GLTPLH A++A N + +P + L + + +D + L+QM
Sbjct: 143 QVDLEARDFEGLTPLHTAILALNVAM-------RPSDLCPRVLSTQARDRLDCVHMLLQM 195
Query: 602 GAAVEAKDRKSGRTALHLAAEEANLELIRLFLELP--SCLSFVNAKAYNGNTALHVAASL 659
GA +++ KS +T LHLA + AN L++L LELP +FVN KA+ GNTALH+AA+L
Sbjct: 196 GANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAAL 254
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPP 717
Q VR L+ GADP+ RNLENEQPVHL+ GP E +R++LK + APP
Sbjct: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV---APP 309
>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
Length = 454
Score = 113 bits (282), Expect = 7e-25
Identities = 97/312 (31%), Positives = 140/312 (44%), Gaps = 43/312 (13%)
Query: 400 PFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRAL 459
P MG+P L L+ E A+I+ D DGDT LHIAV QG
Sbjct: 93 PTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMAT--RADEDGDTPLHIAVVQGNLPA 150
Query: 460 SYVLARKMN-ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLH 518
+ L LDI + Q+ +AV +V+ LV GA D G+T H
Sbjct: 151 VHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAH 210
Query: 519 VCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHS 578
+ E L+A+ A +DLEA NYDGLT LH AV
Sbjct: 211 LACEHRSPTCLRALLDSAAPGT--LDLEARNYDGLTALHVAV------------------ 250
Query: 579 PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSC 638
N +T++ L++ GA ++A D KSGR+ L A E +L +++L L+
Sbjct: 251 ---------NTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHG-- 299
Query: 639 LSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPV 698
+ VNA+ Y+G++ALH A+ L VR L+R GAD S +N N+ P+ +
Sbjct: 300 -ANVNAQMYSGSSALHSASGRGL----LPLVRTLVRSGADSSLKNCHNDTPLMVAR---- 350
Query: 699 GEQIRRILKGKS 710
++ IL+GK+
Sbjct: 351 SRRVIDILRGKA 362
>gi|117320531 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform a [Homo sapiens]
Length = 900
Score = 101 bits (251), Expect = 3e-21
Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)
Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577
Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
L+A+ Q GA Q L +++GL P+H AV A SPE +LL
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619
Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
+ GA VEA +R+ GRTALHLA E L L+ + + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666
Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712
>gi|117320540 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 101 bits (251), Expect = 3e-21
Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)
Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577
Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
L+A+ Q GA Q L +++GL P+H AV A SPE +LL
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619
Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
+ GA VEA +R+ GRTALHLA E L L+ + + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666
Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712
>gi|117320527 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 101 bits (251), Expect = 3e-21
Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 46/293 (15%)
Query: 415 KSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRA----LSYVLARKMNAL 470
++L + V + L + ++D +GDT LH+A+ G+ + + YV+ + L
Sbjct: 459 RALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQD-L 517
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVC--AEKGHSQV 528
++++ H Q+ +AV Q +V L+ +GA D G + +H+ A G ++
Sbjct: 518 GVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPEL 577
Query: 529 LQAI-QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLK 587
L+A+ Q GA Q L +++GL P+H AV A SPE +LL
Sbjct: 578 LRALLQSGAPAVPQL--LHMPDFEGLYPVHLAVRAR--------------SPECLDLL-- 619
Query: 588 NKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAY 647
+ GA VEA +R+ GRTALHLA E L L+ + + VNA+ +
Sbjct: 620 -----------VDSGAEVEATERQGGRTALHLATEMEELGLVTHL--VTKLRANVNARTF 666
Query: 648 NGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGE 700
GNT LH+AA L Y RLL++ GAD + ENE+P+ +P P +
Sbjct: 667 AGNTPLHLAAGLGYP----TLTRLLLKAGAD---IHAENEEPLCPLPSPPTSD 712
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 94.4 bits (233), Expect = 3e-19
Identities = 77/273 (28%), Positives = 128/273 (46%), Gaps = 39/273 (14%)
Query: 416 SLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNAL---HM 472
+LF + V + L + + +D +GD+ LH+A+ L L + L +
Sbjct: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575
Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
++++ Q+ +AV Q +V+DL+ GA ++ D G + LH+ A++GH +VL +
Sbjct: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
K + + L+ N DGL +H A+++++ +
Sbjct: 636 LKHKKAA---LLLDHPNGDGLNAIHLAMMSNS---------------------------L 665
Query: 593 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 652
+ L+ GA V A+++KSGRTALHLA E N+ L L + V++ Y+G T
Sbjct: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGD--AHVDSTTYDGTTP 723
Query: 653 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLE 685
LH+AA T+L A LL GADP N E
Sbjct: 724 LHIAAG--RGSTRLAA--LLKAAGADPLVENFE 752
Score = 36.2 bits (82), Expect = 0.11
Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 595 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCL---SFVNAKAYNGNT 651
+K L+ + + A ++G + LHLA + +L+R LE+ S L +N + T
Sbjct: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
Query: 652 ALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGK 709
LH+A + Q D V L+R GAD S + +HL + + +LK K
Sbjct: 586 PLHLAVITK----QEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK 639
>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, epsilon [Homo sapiens]
Length = 500
Score = 90.9 bits (224), Expect = 4e-18
Identities = 80/260 (30%), Positives = 122/260 (46%), Gaps = 39/260 (15%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
DGDT +H+AV A+ + + +LDI+ + Q+A +AV +Q V+ LV
Sbjct: 258 DGDTLVHLAVIHEAPAV-LLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLK 316
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAV----GSNQFVDLEATNYDGLTPLHC 558
GA D G T LHV ++ H + + +G G++ +DL+ N+ GL LH
Sbjct: 317 GASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHI 376
Query: 559 AVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALH 618
A LQ+NQ + ELLL+N GA ++ ++ SG+TALH
Sbjct: 377 AT---------LQKNQP-----LMELLLRN-------------GADIDVQEGTSGKTALH 409
Query: 619 LAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGAD 678
LA E L++ L+ + V+A+ NG T LH+AA + L + GAD
Sbjct: 410 LAVETQERGLVQFLLQAG---AQVDARMLNGCTPLHLAAGRGL----MGISSTLCKAGAD 462
Query: 679 PSTRNLENEQPVHLVPDGPV 698
RN+E+E P L + V
Sbjct: 463 SLLRNVEDETPQDLTEESLV 482
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 89.4 bits (220), Expect = 1e-17
Identities = 76/283 (26%), Positives = 131/283 (46%), Gaps = 39/283 (13%)
Query: 412 QLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNA-L 470
Q+ K L + ++E +E + Q L++D GD+FLH+A+ +AL+ + R++ L
Sbjct: 44 QMVKELQEIRLEPQEVPRGSEPWKQQLTED--GDSFLHLAIIHEEKALTMEVIRQVKGDL 101
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 530
L+ + + Q+ +AV NQ I + L+ G D G TPLH+ E+G +
Sbjct: 102 AFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVG 161
Query: 531 AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKS 590
+ + + L+ATNY+G T LH A I
Sbjct: 162 VLTQSCTTPHLHSILKATNYNGHTCLHLASI---------------------------HG 194
Query: 591 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
+ ++ L+ +GA V A++ +GRTALHLA + N +L+ L L+ C + VN Y G
Sbjct: 195 YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLK---CGADVNRVTYQGY 251
Query: 651 TALHV-----AASLQYRLTQLDAVRL-LMRKGADPSTRNLENE 687
+ + + +Q +L QL L ++ + D + + E+E
Sbjct: 252 SPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESE 294
Score = 30.8 bits (68), Expect = 4.6
Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 11/86 (12%)
Query: 611 KSGRTALHLAA----EEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQL 666
+ G + LHLA + +E+IR ++ L+F+N + T LH+A Q
Sbjct: 72 EDGDSFLHLAIIHEEKALTMEVIR---QVKGDLAFLNFQNNLQQTPLHLAVITN----QP 124
Query: 667 DAVRLLMRKGADPSTRNLENEQPVHL 692
+ L+ G DP R+ P+HL
Sbjct: 125 EIAEALLGAGCDPELRDFRGNTPLHL 150
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 81.6 bits (200), Expect = 2e-15
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN
Sbjct: 82 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V
Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 192
Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
+AH +H RN + V LL+N D +
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 236
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V
Sbjct: 237 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 288
Query: 670 RLLMRKGADPSTRNLENEQPVH 691
RLL+ +GA T+ + P+H
Sbjct: 289 RLLLDRGAQIETKTKDELTPLH 310
Score = 80.1 bits (196), Expect = 7e-15
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S+ +G T LHIA + + +L + ++ D +G + VA IV++
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 455
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 509
Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A I H N V L+ N P+ + + + V+T+ L++ A+ +A K
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 568
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 621
Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ +G P + P+H+ E R +L+
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
+G T LH+AV + +L + + H NG + +A NQ + + L+
Sbjct: 601 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 657
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
G N G TPLH+ A++GH++++ + N N GLTPLH
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 709
Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
Q+ H P V ++L+K+ +VD + G T LH+A+
Sbjct: 710 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 743
Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+
Sbjct: 744 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 796
Query: 683 NLENEQPV 690
+ + P+
Sbjct: 797 SSDGTTPL 804
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
Q +K D T LH A G +S +L ++ + K NG S +A +
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T
Sbjct: 354 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 406
Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
PLH A ++ V EL V E L + +K L+Q GA+
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
+ K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ +
Sbjct: 467 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 518
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
V+LL+ A+P+ P+H+ E + +L+ ++ Q
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L N LSK G T LHIA ++ +L +N ++ NG + +A
Sbjct: 226 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 280
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A
Sbjct: 281 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 334
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
+GL+P+H A + + R + E+ ++ L + + + K L+
Sbjct: 335 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ +
Sbjct: 392 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 447
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
+ L V+ L+++GA P+ N++ E P+H+ E + +L+ K+
Sbjct: 448 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K +
Sbjct: 377 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 430
Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
+A GLTPLH A + H +V LQR P+ V+ + + K L+
Sbjct: 431 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q A V AK K +T LH AA + +++L LE + N G+T LH+AA
Sbjct: 491 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 544
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R ++ V L+ K A + + P+H+
Sbjct: 545 --REGHVETVLALLEKEASQACMTKKGFTPLHV 575
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 81.6 bits (200), Expect = 2e-15
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN
Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159
Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
+AH +H RN + V LL+N D +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255
Query: 670 RLLMRKGADPSTRNLENEQPVH 691
RLL+ +GA T+ + P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277
Score = 80.1 bits (196), Expect = 7e-15
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S+ +G T LHIA + + +L + ++ D +G + VA IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476
Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A I H N V L+ N P+ + + + V+T+ L++ A+ +A K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588
Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ +G P + P+H+ E R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
+G T LH+AV + +L + + H NG + +A NQ + + L+
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
G N G TPLH+ A++GH++++ + N N GLTPLH
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676
Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
Q+ H P V ++L+K+ +VD + G T LH+A+
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710
Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763
Query: 683 NLENEQPV 690
+ + P+
Sbjct: 764 SSDGTTPL 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
Q +K D T LH A G +S +L ++ + K NG S +A +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373
Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
PLH A ++ V EL V E L + +K L+Q GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
+ K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ +
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
V+LL+ A+P+ P+H+ E + +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L N LSK G T LHIA ++ +L +N ++ NG + +A
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
+GL+P+H A + + R + E+ ++ L + + + K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
+ L V+ L+++GA P+ N++ E P+H+ E + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397
Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
+A GLTPLH A + H +V LQR P+ V+ + + K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q A V AK K +T LH AA + +++L LE + N G+T LH+AA
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R ++ V L+ K A + + P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542
Score = 43.5 bits (101), Expect = 7e-04
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
+ + +E + ++F A + D + G +NT + G LH+ +++GH V+
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
+ + K + LE T G T LH A +A + VV E
Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96
Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
L+ GA V A+ +K G T L++AA+E +LE+++ LE
Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 81.6 bits (200), Expect = 2e-15
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN
Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159
Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
+AH +H RN + V LL+N D +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255
Query: 670 RLLMRKGADPSTRNLENEQPVH 691
RLL+ +GA T+ + P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277
Score = 80.1 bits (196), Expect = 7e-15
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S+ +G T LHIA + + +L + ++ D +G + VA IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476
Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A I H N V L+ N P+ + + + V+T+ L++ A+ +A K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588
Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ +G P + P+H+ E R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
+G T LH+AV + +L + + H NG + +A NQ + + L+
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
G N G TPLH+ A++GH++++ + N N GLTPLH
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676
Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
Q+ H P V ++L+K+ +VD + G T LH+A+
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710
Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763
Query: 683 NLENEQPV 690
+ + P+
Sbjct: 764 SSDGTTPL 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
Q +K D T LH A G +S +L ++ + K NG S +A +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373
Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
PLH A ++ V EL V E L + +K L+Q GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
+ K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ +
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
V+LL+ A+P+ P+H+ E + +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L N LSK G T LHIA ++ +L +N ++ NG + +A
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
+GL+P+H A + + R + E+ ++ L + + + K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
+ L V+ L+++GA P+ N++ E P+H+ E + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397
Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
+A GLTPLH A + H +V LQR P+ V+ + + K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q A V AK K +T LH AA + +++L LE + N G+T LH+AA
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R ++ V L+ K A + + P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542
Score = 43.5 bits (101), Expect = 7e-04
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
+ + +E + ++F A + D + G +NT + G LH+ +++GH V+
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
+ + K + LE T G T LH A +A + VV E
Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96
Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
L+ GA V A+ +K G T L++AA+E +LE+++ LE
Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 81.6 bits (200), Expect = 2e-15
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN
Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159
Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
+AH +H RN + V LL+N D +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255
Query: 670 RLLMRKGADPSTRNLENEQPVH 691
RLL+ +GA T+ + P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277
Score = 80.1 bits (196), Expect = 7e-15
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S+ +G T LHIA + + +L + ++ D +G + VA IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476
Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A I H N V L+ N P+ + + + V+T+ L++ A+ +A K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588
Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ +G P + P+H+ E R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
+G T LH+AV + +L + + H NG + +A NQ + + L+
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
G N G TPLH+ A++GH++++ + N N GLTPLH
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676
Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
Q+ H P V ++L+K+ +VD + G T LH+A+
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710
Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763
Query: 683 NLENEQPV 690
+ + P+
Sbjct: 764 SSDGTTPL 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
Q +K D T LH A G +S +L ++ + K NG S +A +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373
Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
PLH A ++ V EL V E L + +K L+Q GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
+ K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ +
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
V+LL+ A+P+ P+H+ E + +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L N LSK G T LHIA ++ +L +N ++ NG + +A
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
+GL+P+H A + + R + E+ ++ L + + + K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
+ L V+ L+++GA P+ N++ E P+H+ E + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397
Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
+A GLTPLH A + H +V LQR P+ V+ + + K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q A V AK K +T LH AA + +++L LE + N G+T LH+AA
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R ++ V L+ K A + + P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542
Score = 43.5 bits (101), Expect = 7e-04
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
+ + +E + ++F A + D + G +NT + G LH+ +++GH V+
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
+ + K + LE T G T LH A +A + VV E
Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96
Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
L+ GA V A+ +K G T L++AA+E +LE+++ LE
Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 81.6 bits (200), Expect = 2e-15
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 51/262 (19%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A +G + L K +L+ G +A +A A Q +V++LVN GA VN
Sbjct: 49 LHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL-------HCAV 560
G TPL++ A++ H +V++ + + G+NQ V E DG TPL H V
Sbjct: 106 AQSQKGFTPLYMAAQENHLEVVKFLLEN--GANQNVATE----DGFTPLAVALQQGHENV 159
Query: 561 IAH-----------NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
+AH +H RN + V LL+N D +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLS------------- 203
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
K+G T LH+AA NL + +L L + ++F NG T LH+A+ R + V
Sbjct: 204 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFT---PQNGITPLHIAS----RRGNVIMV 255
Query: 670 RLLMRKGADPSTRNLENEQPVH 691
RLL+ +GA T+ + P+H
Sbjct: 256 RLLLDRGAQIETKTKDELTPLH 277
Score = 80.1 bits (196), Expect = 7e-15
Identities = 78/275 (28%), Positives = 123/275 (44%), Gaps = 23/275 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S+ +G T LHIA + + +L + ++ D +G + VA IV++
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVTESGLTPLHVASFMGHLPIVKN 422
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L+ GA N ++ TPLH+ A GH++V + + + N A D TPLHC
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN------AKAKDDQTPLHC 476
Query: 559 AV-IAH-NAVVHELQRNQQPH----SPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A I H N V L+ N P+ + + + V+T+ L++ A+ +A K
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKK 535
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LH+AA+ + + L LE + NA NG T LHVA LD V+LL
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLTPLHVAV----HHNNLDIVKLL 588
Query: 673 MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ +G P + P+H+ E R +L+
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 44/248 (17%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
+G T LH+AV + +L + + H NG + +A NQ + + L+
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHS---PAWNGYTPLHIAAKQNQVEVARSLLQY 624
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA 562
G N G TPLH+ A++GH++++ + N N GLTPLH
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN------LGNKSGLTPLHLVA-- 676
Query: 563 HNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAE 622
Q+ H P V ++L+K+ +VD + G T LH+A+
Sbjct: 677 -----------QEGHVP-VADVLIKHGVMVDA--------------TTRMGYTPLHVASH 710
Query: 623 EANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR 682
N++L++ L+ + VNAK G + LH AA + D V LL++ GA P+
Sbjct: 711 YGNIKLVKFLLQHQ---ADVNAKTKLGYSPLHQAAQQGH----TDIVTLLLKNGASPNEV 763
Query: 683 NLENEQPV 690
+ + P+
Sbjct: 764 SSDGTTPL 771
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%)
Query: 436 QFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI 495
Q +K D T LH A G +S +L ++ + K NG S +A +
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEIL---LDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-QKGAVGSNQFVDLEATNYDGLT 554
V+ L+ A+++ TPLHV A GH +V + + KGA +++ ++ G T
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-------GFT 373
Query: 555 PLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD------TIKCLIQMGAAVEAK 608
PLH A ++ V EL V E L + +K L+Q GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
+ K T LH+AA + E+ + L+ + VNAKA + T LH AA R+ +
Sbjct: 434 NVKV-ETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQ 712
V+LL+ A+P+ P+H+ E + +L+ ++ Q
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/291 (23%), Positives = 134/291 (46%), Gaps = 31/291 (10%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L N LSK G T LHIA ++ +L +N ++ NG + +A
Sbjct: 193 LQNDPNPDVLSKT--GFTPLHIAAHYENLNVAQLL---LNRGASVNFTPQNGITPLHIAS 247
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
++V+ L++ GAQ+ T TPLH A GH ++ + + + ++A
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL------LDHGAPIQAK 301
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVD---------TIKCLI 599
+GL+P+H A + + R + E+ ++ L + + + K L+
Sbjct: 302 TKNGLSPIHMAAQGDHL---DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
GA ++ +G T LH+A ++ ++ ++ L L+ + ++A +G T LHVA+ +
Sbjct: 359 DKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGAS---IDAVTESGLTPLHVASFM 414
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
+ L V+ L+++GA P+ N++ E P+H+ E + +L+ K+
Sbjct: 415 GH----LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 70.1 bits (170), Expect = 7e-12
Identities = 61/213 (28%), Positives = 97/213 (45%), Gaps = 20/213 (9%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA H + + L++ GA+ N+ G TPLH+ +K H +V++ + K +
Sbjct: 344 VAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG------ASI 397
Query: 546 EATNYDGLTPLHCA-VIAHNAVVHE-LQRNQQPHSPEVQE----LLLKNKSLVDTIKCLI 599
+A GLTPLH A + H +V LQR P+ V+ + + K L+
Sbjct: 398 DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q A V AK K +T LH AA + +++L LE + N G+T LH+AA
Sbjct: 458 QNKAKVNAK-AKDDQTPLHCAARIGHTNMVKLLLENN---ANPNLATTAGHTPLHIAA-- 511
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R ++ V L+ K A + + P+H+
Sbjct: 512 --REGHVETVLALLEKEASQACMTKKGFTPLHV 542
Score = 43.5 bits (101), Expect = 7e-04
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 38/166 (22%)
Query: 471 HMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGH-SQVL 529
+ + +E + ++F A + D + G +NT + G LH+ +++GH V+
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVV 62
Query: 530 QAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA-HNAVVHELQRNQQPHSPEVQELLLKN 588
+ + K + LE T G T LH A +A + VV E
Sbjct: 63 ELLHKEII-------LETTTKKGNTALHIAALAGQDEVVRE------------------- 96
Query: 589 KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
L+ GA V A+ +K G T L++AA+E +LE+++ LE
Sbjct: 97 ---------LVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 79.0 bits (193), Expect = 1e-14
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 321
Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
++ H A V + L + P++ +
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 381
Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
+ K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N
Sbjct: 382 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440
Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
+ G TALH+AA R Q++ VR L+R GA R E + P+H+
Sbjct: 441 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 482
Score = 79.0 bits (193), Expect = 1e-14
Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S +G T LH+A + ++ +L K + H NG + +A NQ I
Sbjct: 570 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 626
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 679
Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
A +A H ++ ++ + V + L++ GA V AK K
Sbjct: 680 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 738
Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
+G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++
Sbjct: 739 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 794
Query: 672 LMRKGADPSTRNLENEQ 688
+ + +T E +
Sbjct: 795 VTEEVTTTTTTITEKHK 811
Score = 72.4 bits (176), Expect = 1e-12
Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
A +T G TPL V ++GH+Q + + ++ + L LH A
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 182
Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
+ L Q H+ +VQ ++ N++ V+ L+ GAAV+
Sbjct: 183 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
R +G T LH+A++ N +++L L+ ++AK +G T LH AA R
Sbjct: 242 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 293
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
V LL+ +GA R P+H+ G E ++ +L+ K+
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 335
Score = 70.9 bits (172), Expect = 4e-12
Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G
Sbjct: 410 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
A V+ +TPLH+ + G ++++Q + + +A +G TPLH
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 520
Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
+V+ H L ++ +P + K SL D K L+Q AA ++ K+G
Sbjct: 521 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 575
Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 628
Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
GA+ + + P+HL + + +L KG +I
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Score = 44.3 bits (103), Expect = 4e-04
Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)
Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q +
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 62
Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
+G VD + G T LH A +A A + +
Sbjct: 63 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 92
Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
K L++ GA + A+ ++G T L++AA+E ++++++ LE
Sbjct: 93 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 130
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 79.0 bits (193), Expect = 1e-14
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342
Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
++ H A V + L + P++ +
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
+ K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
+ G TALH+AA R Q++ VR L+R GA R E + P+H+
Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Score = 79.0 bits (193), Expect = 1e-14
Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S +G T LH+A + ++ +L K + H NG + +A NQ I
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700
Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
A +A H ++ ++ + V + L++ GA V AK K
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759
Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
+G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815
Query: 672 LMRKGADPSTRNLENEQ 688
+ + +T E +
Sbjct: 816 VTEEVTTTTTTITEKHK 832
Score = 72.4 bits (176), Expect = 1e-12
Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
A +T G TPL V ++GH+Q + + ++ + L LH A
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203
Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
+ L Q H+ +VQ ++ N++ V+ L+ GAAV+
Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
R +G T LH+A++ N +++L L+ ++AK +G T LH AA R
Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
V LL+ +GA R P+H+ G E ++ +L+ K+
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Score = 70.9 bits (172), Expect = 4e-12
Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G
Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
A V+ +TPLH+ + G ++++Q + + +A +G TPLH
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541
Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
+V+ H L ++ +P + K SL D K L+Q AA ++ K+G
Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596
Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649
Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
GA+ + + P+HL + + +L KG +I
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 44.3 bits (103), Expect = 4e-04
Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)
Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q +
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83
Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
+G VD + G T LH A +A A + +
Sbjct: 84 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113
Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
K L++ GA + A+ ++G T L++AA+E ++++++ LE
Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 79.0 bits (193), Expect = 1e-14
Identities = 77/289 (26%), Positives = 129/289 (44%), Gaps = 58/289 (20%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T LHIA G ++ +L + A+ D NG + VA +V+ L++ G
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGAAV---DFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCA--- 559
Q++ G TPLH A GH QV++ +++GA L A +GL+PLH A
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-------PLLARTKNGLSPLHMAAQG 342
Query: 560 --------VIAHNAVVHE------------------------LQRNQQPHSPEVQEL--- 584
++ H A V + L + P++ +
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 585 -LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN 643
+ K+ + ++ L++ GA+++A +SG T +H+AA +L ++ L L+ + N
Sbjct: 403 HIACKKNRIKVMELLVKYGASIQA-ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 644 AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
+ G TALH+AA R Q++ VR L+R GA R E + P+H+
Sbjct: 462 IR---GETALHMAA----RAGQVEVVRCLLRNGALVDARAREEQTPLHI 503
Score = 79.0 bits (193), Expect = 1e-14
Identities = 69/257 (26%), Positives = 117/257 (45%), Gaps = 22/257 (8%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
S +G T LH+A + ++ +L K + H NG + +A NQ I
Sbjct: 591 SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT---AKNGYTPLHIAAKKNQMQIAST 647
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHS-QVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
L+N GA+ N G TPLH+ +++GH+ V + KGA ++ + GLT LH
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-------NIHMSTKSGLTSLH 700
Query: 558 CAV------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
A +A H ++ ++ + V + L++ GA V AK K
Sbjct: 701 LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAK-TK 759
Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
+G T LH AA++ + +I + L+ + NA NGNTAL +A L Y ++ +D +++
Sbjct: 760 NGYTPLHQAAQQGHTHIINVLLQHG---AKPNATTANGNTALAIAKRLGY-ISVVDTLKV 815
Query: 672 LMRKGADPSTRNLENEQ 688
+ + +T E +
Sbjct: 816 VTEEVTTTTTTITEKHK 832
Score = 72.4 bits (176), Expect = 1e-12
Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 37/282 (13%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G+T LHIA G+ + VL ++ ++ + NG + +A N +V+ L+ G
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINA---QSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAH 563
A +T G TPL V ++GH+Q + + ++ + L LH A
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAIL----------LENDTKGKVRLPALHIAARKD 203
Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSL---------------VDTIKCLIQMGAAVEAK 608
+ L Q H+ +VQ ++ N++ V+ L+ GAAV+
Sbjct: 204 DTKSAALLL-QNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
R +G T LH+A++ N +++L L+ ++AK +G T LH AA R
Sbjct: 263 AR-NGITPLHVASKRGNTNMVKLLLDRG---GQIDAKTRDGLTPLHCAA----RSGHDQV 314
Query: 669 VRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKS 710
V LL+ +GA R P+H+ G E ++ +L+ K+
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Score = 70.9 bits (172), Expect = 4e-12
Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 32/279 (11%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T +H+A G L+ VL N D+ G++A +A A Q +V+ L+ G
Sbjct: 431 GLTPIHVAAFMGH--LNIVLLLLQNGASP-DVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH------ 557
A V+ +TPLH+ + G ++++Q + + +A +G TPLH
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQ------HMAHPDAATTNGYTPLHISAREG 541
Query: 558 ----CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSG 613
+V+ H L ++ +P + K SL D K L+Q AA ++ K+G
Sbjct: 542 QVDVASVLLEAGAAHSL-ATKKGFTP--LHVAAKYGSL-DVAKLLLQRRAAADSAG-KNG 596
Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
T LH+AA N ++ L LE + +A A NG T LH+AA + Q+ L+
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAA----KKNQMQIASTLL 649
Query: 674 RKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL-KGKSI 711
GA+ + + P+HL + + +L KG +I
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 44.3 bits (103), Expect = 4e-04
Identities = 40/159 (25%), Positives = 72/159 (45%), Gaps = 35/159 (22%)
Query: 476 KEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKG 535
K + S + A A N +V+ L G +NT + G LH+ A++GH ++Q +
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQEL--- 83
Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
+G VD + G T LH A +A A + +
Sbjct: 84 -LGRGSSVD--SATKKGNTALHIASLAGQA---------------------------EVV 113
Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE 634
K L++ GA + A+ ++G T L++AA+E ++++++ LE
Sbjct: 114 KVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLE 151
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 77.0 bits (188), Expect = 6e-14
Identities = 74/281 (26%), Positives = 127/281 (45%), Gaps = 23/281 (8%)
Query: 410 TTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGD---TFLHIAVAQGRRALSYVLARK 466
TT+ G + + + ++AN+ + S DA G T LH+A + ++ +L +
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 467 MNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHS 526
+ H NG + +A NQ I L+ GA N G +H+ A++GH
Sbjct: 621 GASPHAA---AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV 677
Query: 527 QVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 586
++ + +G N V+L +N GLTPLH A V E+ NQ H ++
Sbjct: 678 DMVSLL----LGRNANVNL--SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731
Query: 587 KNKSL------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLS 640
+ + + L+Q A V AK K+G T LH AA++ + +I + L+ +
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKT-KNGYTPLHQAAQQGHTHIINVLLQNNAS-- 788
Query: 641 FVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPST 681
N NGNTAL +A L Y ++ +D ++++ + +T
Sbjct: 789 -PNELTVNGNTALGIARRLGY-ISVVDTLKIVTEETMTTTT 827
Score = 73.9 bits (180), Expect = 5e-13
Identities = 71/255 (27%), Positives = 110/255 (43%), Gaps = 46/255 (18%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
+K +G T LHIA + R + +L + ++ + +G + VA IV
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT---ESGLTPIHVAAFMGHVNIVSQ 451
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLH 557
L++ GA NTT+ G T LH+ A G ++V++ +Q GA +EA D TPLH
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-------QVEAKAKDDQTPLH 504
Query: 558 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
+ A D ++ L+Q GA+ A SG T L
Sbjct: 505 ISARLGKA---------------------------DIVQQLLQQGASPNAA-TTSGYTPL 536
Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
HL+A E + ++ L+ + LS K G T LHVAA + +L+ LL++K A
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKK---GFTPLHVAA----KYGKLEVANLLLQKSA 589
Query: 678 DPSTRNLENEQPVHL 692
P P+H+
Sbjct: 590 SPDAAGKSGLTPLHV 604
Score = 70.9 bits (172), Expect = 4e-12
Identities = 72/279 (25%), Positives = 125/279 (44%), Gaps = 24/279 (8%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T LHIA G ++ +L +N +D N + VA +V+ L++ G
Sbjct: 235 GFTPLHIAAHYGNINVATLL---LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG 291
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIA- 562
A+++ G TPLH A GH QV++ + A + + +GL+PLH A
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA------APILSKTKNGLSPLHMATQGD 345
Query: 563 HNAVVHELQRNQQPHSPEVQELL-----LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
H V L ++ P + L + K L+ A AK +G T L
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK-ALNGFTPL 404
Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
H+A ++ ++++ L L+ + + A +G T +HVAA + + ++ V LM GA
Sbjct: 405 HIACKKNRIKVMELLLKHGAS---IQAVTESGLTPIHVAAFMGH----VNIVSQLMHHGA 457
Query: 678 DPSTRNLENEQPVHLVPDGPVGEQIRRILK-GKSIQQRA 715
P+T N+ E +H+ E +R +++ G ++ +A
Sbjct: 458 SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/282 (25%), Positives = 120/282 (42%), Gaps = 44/282 (15%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G+T LH+A G+ + L + ++ K + Q+ ++ + IVQ L+ G
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGA---QVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKGAV--------GSNQFVD 544
A N G TPLH+ A +GH V + +KG G + +
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582
Query: 545 L--------EATNYDGLTPLHCAVIAHNAVVHELQRNQ--QPHSPEVQEL----LLKNKS 590
L +A GLTPLH A N V L +Q PH+ + K+
Sbjct: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642
Query: 591 LVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
+D L++ GA A R+ G ++HLAA+E +++++ L L + VN +G
Sbjct: 643 QMDIATTLLEYGADANAVTRQ-GIASVHLAAQEGHVDMVSLLL---GRNANVNLSNKSGL 698
Query: 651 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
T LH+AA + +++ +L+ +GA + P+H+
Sbjct: 699 TPLHLAA----QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736
Score = 66.2 bits (160), Expect = 1e-10
Identities = 66/255 (25%), Positives = 109/255 (42%), Gaps = 23/255 (9%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T +H+A G + L + + +++ G++A +A + Q +V+ LV G
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR---GETALHMAARSGQAEVVRYLVQDG 489
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 560
AQV +TPLH+ A G + ++Q + + N A G TPLH +
Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN------AATTSGYTPLHLSAREG 543
Query: 561 ---IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
+A + H + + ++ L+Q A+ +A KSG T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG-KSGLTPL 602
Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
H+AA N ++ L L+ + +A A NG T LH+AA + Q+D L+ GA
Sbjct: 603 HVAAHYDNQKVALLLLDQGAS---PHAAAKNGYTPLHIAA----KKNQMDIATTLLEYGA 655
Query: 678 DPSTRNLENEQPVHL 692
D + + VHL
Sbjct: 656 DANAVTRQGIASVHL 670
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/304 (24%), Positives = 119/304 (39%), Gaps = 56/304 (18%)
Query: 424 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 483
+++ K S+D+ DA+ +AL Y+ N + ++I NG +A
Sbjct: 23 EKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYI----KNGVD-INICNQNGLNA 77
Query: 484 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 543
+A +V +L+ A V+ G T LH+ + G ++V++ + N
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN--- 134
Query: 544 DLEATNYDGLTPLHCAVIA-HNAVVHELQRN-------------------QQPHSPEVQE 583
A + +G TPL+ A H VV L N QQ H +V
Sbjct: 135 ---AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD-QVVS 190
Query: 584 LLLKN----------------KSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLE 627
LLL+N K L+Q + + KSG T LH+AA N+
Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNIN 249
Query: 628 LIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENE 687
+ L L + + F A N T LHVA+ + + V+LL+ +GA + +
Sbjct: 250 VATLLLNRAAAVDFT---ARNDITPLHVAS----KRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 688 QPVH 691
P+H
Sbjct: 303 TPLH 306
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 76.3 bits (186), Expect = 9e-14
Identities = 70/215 (32%), Positives = 100/215 (46%), Gaps = 25/215 (11%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
VA Q V L+N GA+V T GRTPLH+ A KGH V+Q + K DL
Sbjct: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAG------CDL 68
Query: 546 EATNYDGLTPLHCAVIAHN-----AVVHE---LQRNQQPHSPEVQELLLKNKSLVDTIKC 597
+ + T LH A + N A++HE L R + + + E S + K
Sbjct: 69 DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFS--QSAKL 126
Query: 598 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAA 657
L++ GA V AK+ K+G TALHLA + ++ + R+ L S N G+T LHVAA
Sbjct: 127 LVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA---GDTCLHVAA 182
Query: 658 SLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
R L +RLL+ +N + +H+
Sbjct: 183 ----RYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
Score = 72.4 bits (176), Expect = 1e-12
Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 53/300 (17%)
Query: 424 QEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSA 483
Q E+ + I++ ++ G T LH+A +G + +L + A LD+++ Q+A
Sbjct: 22 QTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQIL---LKAGCDLDVQDDGDQTA 78
Query: 484 FQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV 543
A I+ L++ G ++ D G T LH + G SQ + + K G+N
Sbjct: 79 LHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK--AGAN--- 133
Query: 544 DLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGA 603
+ A N G T LH A Q HS + LLL G+
Sbjct: 134 -VLAKNKAGNTALHLAC-------------QNSHSQSTRVLLL--------------AGS 165
Query: 604 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 663
+ K+ +G T LH+AA +L +IRL L + V+ K G+TALHVAA+L ++
Sbjct: 166 RADLKN-NAGDTCLHVAARYNHLSIIRLLL---TAFCSVHEKNQAGDTALHVAAALNHK- 220
Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPV-----HLVPDGPV----GEQIRRILKGKSIQQR 714
++L+ GAD + N + P+ H P+ + Q+ R +G+S++++
Sbjct: 221 ---KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKK 277
Score = 44.7 bits (104), Expect = 3e-04
Identities = 39/148 (26%), Positives = 61/148 (41%), Gaps = 9/148 (6%)
Query: 420 WQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN 479
W + +KL + L+K+ G+T LH+A + VL + A D+K +
Sbjct: 117 WHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL---LLAGSRADLKNNA 173
Query: 480 GQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGS 539
G + VA N I++ L+ V+ + G T LHV A H +V + + +
Sbjct: 174 GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG--- 230
Query: 540 NQFVDLEATNYDGLTPLHCAVIAHNAVV 567
D N G TPL A +N V
Sbjct: 231 ---ADTTIVNNAGQTPLETARYHNNPEV 255
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 75.5 bits (184), Expect = 2e-13
Identities = 74/260 (28%), Positives = 121/260 (46%), Gaps = 27/260 (10%)
Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
D DG LH A G + +L ++ +D +E G + +A N + + LV
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLL---LDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
+ A N + G+TPLHV A GH +++ + ++Q +L+A + TPLH AV
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL------TSQGAELDAQQRNLRTPLHLAV 535
Query: 561 IAH--NAVVHELQRNQQPHSPE------VQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
A+ H L+ P + + + + K L+ K L++ GA++E +
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLI--CKMLLRYGASLELPTHQ- 592
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
G T LHLAA + +LE+I L E + + + A + T LH+AA R + V L
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW---TPLHLAA----RHGEEAVVSAL 645
Query: 673 MRKGADPSTRNLENEQPVHL 692
++ GADP+ P+HL
Sbjct: 646 LQCGADPNAAEQSGWTPLHL 665
Score = 60.8 bits (146), Expect = 4e-09
Identities = 68/252 (26%), Positives = 112/252 (44%), Gaps = 29/252 (11%)
Query: 446 TFLHIAVAQGR-RALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGA 504
T LH+AV +G+ RA+ ++L K A+ D + +G A A ++LI + L+ GA
Sbjct: 529 TPLHLAVERGKVRAIQHLL--KSGAVP--DALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 505 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV-IAH 563
+ G TPLH+ A KGH +++ + + L A N+ TPLH A
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA---LGAVNW---TPLHLAARHGE 638
Query: 564 NAVVHE-LQRNQQPHSPEVQ-----ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
AVV LQ P++ E L ++ + + I L++ A V A++ K G T
Sbjct: 639 EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN-LLEHHANVHARN-KVGWTPA 696
Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
HLAA + N ++++ +E + L + + LQ L + +G
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVS---------CTPLQLALRSRKQGIMSFLEGK 747
Query: 678 DPSTRNLENEQP 689
+PS L +P
Sbjct: 748 EPSVATLGGSKP 759
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 20/203 (9%)
Query: 515 TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV------IAHNAVVH 568
TPLH +G + ++ + V D++ G TPL A + + H
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEV------DVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 569 ELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLEL 628
N+ T + L+ GA V+A++R+ G T LHLAA+ +
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENV 476
Query: 629 IRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQ 688
RL L S + N G T LHVAA + + V+LL +GA+ +
Sbjct: 477 ARL---LVSRQADPNLHEAEGKTPLHVAAYFGH----VSLVKLLTSQGAELDAQQRNLRT 529
Query: 689 PVHLVPDGPVGEQIRRILKGKSI 711
P+HL + I+ +LK ++
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAV 552
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 74.3 bits (181), Expect = 4e-13
Identities = 63/233 (27%), Positives = 109/233 (46%), Gaps = 44/233 (18%)
Query: 477 EHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQ-KG 535
+ + ++A A +A IV+ L+ +G VN D G +PLH+ A G ++++A+ KG
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 536 AVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
A + A N +G TPLH A +K+ +
Sbjct: 97 A-------QVNAVNQNGCTPLHYAA---------------------------SKNRHEIA 122
Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 655
L++ GA +AKD TA+H AA + NL++I + L + N + GNT LH+
Sbjct: 123 VMLLEGGANPDAKDHYEA-TAMHRAAAKGNLKMIHILLYYKAS---TNIQDTEGNTPLHL 178
Query: 656 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
A + +++ +LL+ +GA N E + P+ V G +G ++R+++G
Sbjct: 179 ACDEE----RVEEAKLLVSQGASIYIENKEEKTPLQ-VAKGGLGLILKRMVEG 226
Score = 51.2 bits (121), Expect = 3e-06
Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 4/191 (2%)
Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
D D T LH A + G + L + ++ K+ G S +A +A + IV+ L+
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFL---LQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL 93
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
GAQVN + G TPLH A K ++ + +G + EAT
Sbjct: 94 GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLK 153
Query: 561 IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLA 620
+ H + ++ N Q L ++ V+ K L+ GA++ + K +T L +A
Sbjct: 154 MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI-ENKEEKTPLQVA 212
Query: 621 AEEANLELIRL 631
L L R+
Sbjct: 213 KGGLGLILKRM 223
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 72.4 bits (176), Expect = 1e-12
Identities = 84/309 (27%), Positives = 127/309 (41%), Gaps = 38/309 (12%)
Query: 432 ISQDQFLSKDADG--DTFLHIAVAQGRR-ALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
++ ++ S+D G T LH A GR+ + Y+L N + ++ G A
Sbjct: 44 VTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN----VQARDDGGLIPLHNAC 99
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEA 547
+ +V L+ GA N D W TPLH A KG V + +Q GA + + D
Sbjct: 100 SFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTD-GR 158
Query: 548 TNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL---------------- 591
T D P AV+ EL + + + E LL ++
Sbjct: 159 TALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLA 218
Query: 592 -----VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 646
V ++ L+Q GA V AKD K LH A + E+ L ++ +C VNA
Sbjct: 219 AGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELLVKHGAC---VNAMD 274
Query: 647 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
T LH AAS +++ LL+ GADP+ N N+ + L P + E++
Sbjct: 275 LWQFTPLHEAASKN----RVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEF 330
Query: 707 KGKSIQQRA 715
KG S+ Q A
Sbjct: 331 KGHSLLQAA 339
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/320 (27%), Positives = 132/320 (41%), Gaps = 49/320 (15%)
Query: 403 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYV 462
++GN QL ++ VE + KL + + T LH A R ++
Sbjct: 486 SLGNSEADRQLLEAAKAGDVETVK-KLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 463 LARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAE 522
L + +H K+ G A + + + + LV GA VN D W TPLH A
Sbjct: 545 LLQHGADVHA---KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAA 601
Query: 523 KGHSQVLQ-AIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEV 581
KG ++ + +Q GA D N DG TPL V + + +L R
Sbjct: 602 KGKYEICKLLLQHGA-------DPTKKNRDGNTPLD-LVKDGDTDIQDLLRGDAALLDAA 653
Query: 582 QELLL---KNKSLVDTIKC-------------------------LIQMGAAVEAKDRKSG 613
++ L K S D + C L+Q GA V A+D K G
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQD-KGG 712
Query: 614 RTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLM 673
LH AA ++++ L ++ +C++ + A+ T LH AA Q TQL A LL+
Sbjct: 713 LIPLHNAASYGHVDVAALLIKYNACVNATDKWAF---TPLHEAA--QKGRTQLCA--LLL 765
Query: 674 RKGADPSTRNLENEQPVHLV 693
GADP+ +N E + P+ LV
Sbjct: 766 AHGADPTLKNQEGQTPLDLV 785
Score = 56.2 bits (134), Expect = 1e-07
Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 35/271 (12%)
Query: 446 TFLHIAVAQGRRALSYVLAR---KMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNI 502
T LH+A + + V+ + K+NAL L GQ++ A + L++
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNL------GQTSLHRAAYCGHLQTCRLLLSY 455
Query: 503 GAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVD---LEATNYDGLTPLH-- 557
G N G T L + G+ V Q +Q+G N D LEA + +
Sbjct: 456 GCDPNIISLQGFTALQM----GNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511
Query: 558 CAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTAL 617
C V + N E +++ H + V ++ L+Q GA V AKD K G L
Sbjct: 512 CTVQSVNCRDIEGRQSTPLH-------FAAGYNRVSVVEYLLQHGADVHAKD-KGGLVPL 563
Query: 618 HLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGA 677
H A + E+ L ++ + ++ + + T LH AA+ + + +LL++ GA
Sbjct: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKF---TPLHEAAAKG----KYEICKLLLQHGA 616
Query: 678 DPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
DP+ +N + P+ LV DG I+ +L+G
Sbjct: 617 DPTKKNRDGNTPLDLVKDGDT--DIQDLLRG 645
Score = 50.4 bits (119), Expect = 6e-06
Identities = 60/226 (26%), Positives = 99/226 (43%), Gaps = 25/226 (11%)
Query: 486 VAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL 545
+A N+ IVQ L+ GA V+ D PLH GH +V + + K N
Sbjct: 217 LAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN----- 271
Query: 546 EATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAV 605
A + TPLH A + V L + + + L NKS +D +
Sbjct: 272 -AMDLWQFTPLHEAASKNRVEVCSLLLS---YGADPTLLNCHNKSAID-------LAPTP 320
Query: 606 EAKDRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQY 661
+ K+R + G + L AA EA++ I+ L L ++F + + + TALH AA+ Y
Sbjct: 321 QLKERLAYEFKGHSLLQ-AAREADVTRIKKHLSL-EMVNFKHPQTHE--TALHCAAASPY 376
Query: 662 RLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+ LL+RKGA+ + + E P+H+ + + + ++K
Sbjct: 377 PKRK-QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 71.2 bits (173), Expect = 3e-12
Identities = 73/275 (26%), Positives = 118/275 (42%), Gaps = 28/275 (10%)
Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
D G T LH A G + +L + ++ D K+ A A +V+ LV
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR---AIHWAAYMGHIEVVKLLV 193
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
+ GA+V D TPLH A G V++ + + VD+ N G TPLH A
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL------DLGVDMNEPNAYGNTPLHVAC 247
Query: 561 I-AHNAVVHEL--------QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRK 611
+ VV+EL Q+N++ +P + +L ++ L+ GA V K K
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC--LELLVGNGADVNMKS-K 304
Query: 612 SGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL 671
G+T LH+ A + ++ + ++ + NGNT LH+AA + L +
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAV---IDCEDKNGNTPLHIAARYGHELL----INT 357
Query: 672 LMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
L+ GAD + R + P+HL + R++L
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Score = 66.2 bits (160), Expect = 1e-10
Identities = 70/277 (25%), Positives = 125/277 (45%), Gaps = 24/277 (8%)
Query: 423 EQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDI--KEHNG 480
+ E +L +S + +KD+ T LH AVA VL + H D+ ++ N
Sbjct: 53 DAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-----HSADVNARDKNW 107
Query: 481 QSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSN 540
Q+ +A A + LV + + VN +D GRT LH A GH ++++ + N
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 541 QF--VDLEATN---YDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTI 595
F D A + Y G + +++H A V ++++ ++P + ++ +
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV--TCKDKKSYTP---LHAAASSGMISVV 222
Query: 596 KCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHV 655
K L+ +G + + G T LH+A ++ EL C + VN K G T LH
Sbjct: 223 KYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN---ELIDCGAIVNQKNEKGFTPLHF 278
Query: 656 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
AA+ + L+ LL+ GAD + ++ + + P+H+
Sbjct: 279 AAASTHGALCLE---LLVGNGADVNMKSKDGKTPLHM 312
Score = 60.5 bits (145), Expect = 5e-09
Identities = 94/402 (23%), Positives = 154/402 (38%), Gaps = 87/402 (21%)
Query: 387 GHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKL---ANISQDQFLSKDAD 443
GH A + SL ++ N T L + F+ VE + + A+I ++ K
Sbjct: 561 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKR-- 618
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
T +H A G +L + +DI++ NGQ+ ++V V L+N G
Sbjct: 619 --TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGA-------------------------- 536
A V+ D WGRT LH A GH + + A +Q GA
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736
Query: 537 --VGSNQFVDLEATNYD--GLTPLHCAVIAHNAVVHELQRNQQ--------PHSPEVQEL 584
+ S +D D G T LH A + EL Q+ SP +
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796
Query: 585 LLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNA 644
+ N+ + + + +GA++ GRT LH AA ++E ++L L + ++ V++
Sbjct: 797 INDNEGAAEML--IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854
Query: 645 --------KAYNG-----------------------NTALHVAASLQYRLTQLDAVRLLM 673
A NG NTALH+A S + + L L++
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSAL----LIL 910
Query: 674 RKGADPSTRNLEN---EQPVHLVPDGPVGEQIRRIL-KGKSI 711
K D + N N + P+H+ + ++ +L KG S+
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Score = 58.9 bits (141), Expect = 2e-08
Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 23/259 (8%)
Query: 440 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDL 499
K+ G T LH A A AL L A +++K +G++ + + Q +
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGA--DVNMKSKDGKTPLHMTALHGRFSRSQTI 325
Query: 500 VNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA-IQKGAVGSNQFVDLEATNYDGLTPLHC 558
+ GA ++ D G TPLH+ A GH ++ I GA D G+ PLH
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA-------DTAKRGIHGMFPLHL 378
Query: 559 AVIA--HNAVVHELQRNQQPHSP-EVQELLLKNKSLVDTIKC---LIQMGAAVEAKDRKS 612
A ++ + L +P + L + ++C L+ GA KD K
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD-KF 437
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
GR+ LH AA N + LF + S S VN G T LH AA+ T + L
Sbjct: 438 GRSPLHYAAANCNYQC--LFALVGSGAS-VNDLDERGCTPLHYAATSD---TDGKCLEYL 491
Query: 673 MRKGADPSTRNLENEQPVH 691
+R A+P R+ + VH
Sbjct: 492 LRNDANPGIRDKQGYNAVH 510
Score = 57.0 bits (136), Expect = 6e-08
Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 30/207 (14%)
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 555
V+ L+ VN D RTPLH A G +++++ + N A + LTP
Sbjct: 24 VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN------AKDSKWLTP 77
Query: 556 LHCAV-----------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA 604
LH AV + H+A V+ +N Q + NK+ V + L+ + +
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQ----TPLHIAAANKA-VKCAEALVPLLSN 132
Query: 605 VEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLT 664
V DR +GRTALH AA + E+++L L S + +NA A+H AA + +
Sbjct: 133 VNVSDR-AGRTALHHAAFSGHGEMVKLLL---SRGANINAFDKKDRRAIHWAAYMGH--- 185
Query: 665 QLDAVRLLMRKGADPSTRNLENEQPVH 691
++ V+LL+ GA+ + ++ ++ P+H
Sbjct: 186 -IEVVKLLVSHGAEVTCKDKKSYTPLH 211
Score = 55.8 bits (133), Expect = 1e-07
Identities = 56/237 (23%), Positives = 99/237 (41%), Gaps = 42/237 (17%)
Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
++ +++ ++ A I++ L+ GA+VN D TPLH + +Q +
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVL 93
Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
K + D+ A + + TPLH A N+ E LL N ++
Sbjct: 94 LKHS------ADVNARDKNWQTPLHIAA-----------ANKAVKCAEALVPLLSNVNVS 136
Query: 593 D-----------------TIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLEL 635
D +K L+ GA + A D+K R A+H AA ++E+++L +
Sbjct: 137 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD-RRAIHWAAYMGHIEVVKLLVSH 195
Query: 636 PSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
+ ++ + K+Y T LH AAS + V+ L+ G D + N P+H+
Sbjct: 196 GAEVTCKDKKSY---TPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Score = 44.7 bits (104), Expect = 3e-04
Identities = 66/288 (22%), Positives = 121/288 (42%), Gaps = 38/288 (13%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A G S + +++ +D + G++ A A + L+N GA N
Sbjct: 376 LHLAALSG---FSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN 432
Query: 508 TTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFV-DLEATNYDGLTPLHCAVIAH--- 563
D +GR+PLH A + Q L A+ VGS V DL+ G TPLH A +
Sbjct: 433 KKDKFGRSPLHYAAANCNYQCLFAL----VGSGASVNDLDER---GCTPLHYAATSDTDG 485
Query: 564 NAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAA---------------VEAK 608
+ + L+ + P + Q + S + +Q+ A+ +
Sbjct: 486 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDS 545
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
D ++ + LHLAA + + + + ++ L ++ + +G T L +AA + ++
Sbjct: 546 DNRATISPLHLAAYHGHHQALEVLVQ---SLLDLDVRNSSGRTPLDLAAFKGH----VEC 598
Query: 669 VRLLMRKGADPSTRN-LENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 715
V +L+ +GA ++ + P+H E + R+L G + Q A
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECL-RLLIGNAEPQNA 645
Score = 38.9 bits (89), Expect = 0.017
Identities = 23/93 (24%), Positives = 44/93 (47%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
L + + + +D +T LH+A ++G + ++ K+ ++++ Q+ VA
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCA 521
++VQ+L+ GA V D G TP CA
Sbjct: 935 RNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 71.2 bits (173), Expect = 3e-12
Identities = 108/421 (25%), Positives = 157/421 (37%), Gaps = 92/421 (21%)
Query: 314 PIPPQSPAYEPNLFDGPESQFCPNQSLVSLLG--DQRESENIANPMQTSSSVQQQNDAHL 371
P P+S L F + SL LL D S+ + P + S S +
Sbjct: 306 PPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSE------ 359
Query: 372 HSFSMMPSSACEAMVGHEMASDS---SNTSLPFSNMGNPMNTTQLG------KSLFQWQV 422
S +PSS + + DS S SL S P +T+ LG K L V
Sbjct: 360 ---SKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP-STSDLGTTDVQKKKLVDAIV 415
Query: 423 EQEESKLANISQDQFLSKDAD-GDTFLHIAVAQGRRALSYVLA-----------RKMNAL 470
+ SKL I Q Q + D G + LH+AV G+ + L R L
Sbjct: 416 SGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPL 475
Query: 471 HM-------------------LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDC 511
HM ++ K+ + +A A + L+ A VN D
Sbjct: 476 HMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDF 535
Query: 512 WGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQ 571
GRTP+HV + G +++ + + + VD+ D PLH A
Sbjct: 536 EGRTPMHVACQHGQENIVRILLR------RGVDVSLQGKDAWLPLHYAA----------- 578
Query: 572 RNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 631
Q H P + +LL K Q G +V A+ GRT LHLAA+ + + R+
Sbjct: 579 --WQGHLP-IVKLLAK------------QPGVSVNAQ-TLDGRTPLHLAAQRGHYRVARI 622
Query: 632 FLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVH 691
++L S VN + T LHVAA + T RLL+ +GA + +H
Sbjct: 623 LIDL---CSDVNVCSLLAQTPLHVAAETGHTST----ARLLLHRGAGKEAMTSDGYTALH 675
Query: 692 L 692
L
Sbjct: 676 L 676
Score = 66.6 bits (161), Expect = 8e-11
Identities = 74/267 (27%), Positives = 116/267 (43%), Gaps = 25/267 (9%)
Query: 403 NMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLS---KDADGDTFLHIAVAQGRRAL 459
N NP + + G + VE+ + + + +S KD D T LH A G +
Sbjct: 460 NNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESS 519
Query: 460 SYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTT--DCWGRTPL 517
+ +L K +++ +D + G++ VA Q IV+ L+ G V+ D W PL
Sbjct: 520 TRLLLEKNASVNEVDFE---GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW--LPL 574
Query: 518 HVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN----AVVHELQRN 573
H A +GH +++ + K V + A DG TPLH A + ++ +L +
Sbjct: 575 HYAAWQGHLPIVKLLAK-----QPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 574 QQPHSPEVQELL--LKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRL 631
S Q L T + L+ GA EA G TALHLAA +L ++L
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT-SDGYTALHLAARNGHLATVKL 688
Query: 632 FLELPSCLSFVNAKAYNGNTALHVAAS 658
+E + V A+ TALH+AA+
Sbjct: 689 LVEEK---ADVLARGPLNQTALHLAAA 712
Score = 33.5 bits (75), Expect = 0.71
Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 12/121 (9%)
Query: 446 TFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLI-VQDLVNIGA 504
T LH+A G + + +L + + +G +A +A A N HL V+ LV A
Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMT---SDGYTALHLA-ARNGHLATVKLLVEEKA 694
Query: 505 QVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHN 564
V +T LH+ A GHS+V++ + V ++ + GL+ LH A +
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSADV-------IDLFDEQGLSALHLAAQGRH 747
Query: 565 A 565
A
Sbjct: 748 A 748
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 69.3 bits (168), Expect = 1e-11
Identities = 80/290 (27%), Positives = 126/290 (43%), Gaps = 49/290 (16%)
Query: 439 SKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD 498
++D T LH+A A + LA +++L++ D +G+SA AV + V
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD---RSGRSALHHAVHSGHLETVNL 158
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI-----------QKG------AVGSNQ 541
L+N GA +N D R PLH A GH +VL+ + +KG A S Q
Sbjct: 159 LLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ 218
Query: 542 F----------VDLEATNYDGLTPLHCA-VIAHNAVVHEL--------QRNQQPHSPEVQ 582
+++ N G T LH A + +AV EL Q N + +P
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278
Query: 583 ELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFV 642
+ N +L ++ L+ GA V + K G++ LH+AA ++ ++ S +
Sbjct: 279 AAVSTNGAL--CLELLVNNGADVNYQS-KEGKSPLHMAAIHGRFTRSQILIQNG---SEI 332
Query: 643 NAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
+ GNT LHVAA + L + LM GAD + R + + P+HL
Sbjct: 333 DCADKFGNTPLHVAARYGHEL----LISTLMTNGADTARRGIHDMFPLHL 378
Score = 62.8 bits (151), Expect = 1e-09
Identities = 70/261 (26%), Positives = 114/261 (43%), Gaps = 23/261 (8%)
Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
DA G T L +A+ G ++L K + D++ G++A + L+
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLR---GRTALHRGAVTGCEDCLAALL 741
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEA-TNYDGLTPLHCA 559
+ A V D GRTP+H+ + GH+ VL+ + + A+ ++ L+A +Y G +P+H A
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD---PLDAGVDYSGYSPMHWA 798
Query: 560 VIAHNAVVHELQRNQQPHS-------PEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKS 612
+ EL P S + ++ N+ T L +GA +
Sbjct: 799 SYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDST-TEMLLGALGAKIVNSRDAK 857
Query: 613 GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLL 672
GRT LH AA N+ +R+ L+ + VNA + G TAL AA Q AV L
Sbjct: 858 GRTPLHAAAFADNVSGLRMLLQHQ---AEVNATDHTGRTALMTAA----ENGQTAAVEFL 910
Query: 673 MRKG-ADPSTRNLENEQPVHL 692
+ +G AD + + +HL
Sbjct: 911 LYRGKADLTVLDENKNTALHL 931
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 45/235 (19%)
Query: 448 LHIAVAQG-----RRALS----YVLARKMNALHML------DIKEHNGQSAFQVAVAANQ 492
LH+AV G R+ LS Y + ++ H+L + ++ G++ A +
Sbjct: 376 LHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGN 435
Query: 493 HLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDG 552
+ L++ GA + D +GRTPLH A G Q + G N+ + G
Sbjct: 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE------ADCKG 489
Query: 553 LTPLHCAVIAHNAVVHELQRNQQPHSP-----EVQELL--LKNKSLVDTIKCLIQMGAAV 605
+PLH A + + R +PH+P E E L + K ++ L+ GA
Sbjct: 490 CSPLHYAAAS------DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADP 543
Query: 606 EAKDRKSGRTALHLAAEEANLELIRLFLELP-SCLSFVNA---------KAYNGN 650
+DR+ G TA+H AA N + + L LE+ +CL V + AYNG+
Sbjct: 544 SLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597
Score = 54.3 bits (129), Expect = 4e-07
Identities = 77/300 (25%), Positives = 123/300 (41%), Gaps = 53/300 (17%)
Query: 413 LGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHM 472
L +++F VE+ S L+ L D + T LH A G + +L M+ ++
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVL--DQERRTPLHAAAYVGDVPILQLLL--MSGANV 67
Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
+ K+ + A A+ ++ L+ A VN D +TPLHV A ++ +A+
Sbjct: 68 -NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSL- 591
+ L + G + LH AV H V LL K SL
Sbjct: 127 ------APLLSSLNVADRSGRSALHHAV-------------HSGHLETVNLLLNKGASLN 167
Query: 592 ------------------VDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFL 633
++ +K L+ GA + KDRK G LH AA +E+++ L
Sbjct: 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK-GYGLLHTAAASGQIEVVKYLL 226
Query: 634 ELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRL-LMRKGADPSTRNLENEQPVHL 692
+ + + NA GNTALH+A L DAV + L+ GA+ + N + P+H+
Sbjct: 227 RMGAEIDEPNA---FGNTALHIACYLGQ-----DAVAIELVNAGANVNQPNDKGFTPLHV 278
Score = 53.1 bits (126), Expect = 9e-07
Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 20/218 (9%)
Query: 496 VQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTP 555
V+ L++ +N D RTPLH A G +LQ + N A + LTP
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN------AKDTLWLTP 77
Query: 556 LHCAVIAHNAVV------HELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKD 609
LH A + N V H N + + + + L + +++ D
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
Query: 610 RKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAV 669
R SGR+ALH A +LE + L L + L+ + K LH AA L + L+ +
Sbjct: 138 R-SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE---RQPLHWAAFLGH----LEVL 189
Query: 670 RLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILK 707
+LL+ +GAD ++ + +H E ++ +L+
Sbjct: 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 50.1 bits (118), Expect = 7e-06
Identities = 70/296 (23%), Positives = 108/296 (36%), Gaps = 60/296 (20%)
Query: 444 GDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIG 503
G T LH+A AL L A KE G+S +A + Q L+ G
Sbjct: 272 GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE--GKSPLHMAAIHGRFTRSQILIQNG 329
Query: 504 AQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV--- 560
++++ D +G TPLHV A GH ++ + D + PLH AV
Sbjct: 330 SEIDCADKFGNTPLHVAARYGHELLISTLMTNGA------DTARRGIHDMFPLHLAVLFG 383
Query: 561 -----------------IAHNAVVHELQRNQQPHSPE-VQELLLKNKSLVDTIKCL---I 599
++ + H L ++P+ + L + ++CL +
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH-VAAS 658
GA + +D K GRT LH AA + + + L + + VN G + LH AAS
Sbjct: 444 SSGADLRRRD-KFGRTPLHYAAANGSYQCA---VTLVTAGAGVNEADCKGCSPLHYAAAS 499
Query: 659 LQYRLTQ-----------------------LDAVRLLMRKGADPSTRNLENEQPVH 691
YR + + L+ GADPS R+ + VH
Sbjct: 500 DTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVH 555
Score = 49.7 bits (117), Expect = 1e-05
Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 17/219 (7%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH+A G LA L LD+++H G++A +A V+ L GA
Sbjct: 589 LHLAAYNGHCEALKTLAE---TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 508 TTDCWGR-TPLHVCAEKGHSQVLQAIQKGAVGSNQFVDL-EATNYDGLTPLHCAVI-AHN 564
+ + TPLH A GH+ L + + S + D+ + + G TPL A++ H
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLL----IDSGERADITDVMDAYGQTPLMLAIMNGHV 701
Query: 565 AVVH-ELQRNQQPHSPEVQELLLKNKSLV----DTIKCLIQMGAAVEAKDRKSGRTALHL 619
VH L++ + +++ ++ V D + L+ A V +D K GRT +HL
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFK-GRTPIHL 760
Query: 620 AAEEANLELIRLFLELPSCLSFVNAKA-YNGNTALHVAA 657
A+ + ++R L+ ++A Y+G + +H A+
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799
Score = 48.5 bits (114), Expect = 2e-05
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 18/201 (8%)
Query: 499 LVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHC 558
L++ GA + D G T +H A G+ Q L+ + + + N D+E+T ++PLH
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE--MSFNCLEDVESTI--PVSPLHL 591
Query: 559 AVIAHNAVVHELQR--------NQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 610
A A+N L+ + + H L + + ++ L GA+ K+R
Sbjct: 592 A--AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649
Query: 611 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 670
K T LH AA + + + L ++ + G T L +A + +D V
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH----VDCVH 705
Query: 671 LLMRKGADPSTRNLENEQPVH 691
LL+ KG+ +L +H
Sbjct: 706 LLLEKGSTADAADLRGRTALH 726
Score = 48.1 bits (113), Expect = 3e-05
Identities = 69/291 (23%), Positives = 116/291 (39%), Gaps = 18/291 (6%)
Query: 425 EESKLANISQDQF-LSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIK-EHNGQS 482
E+ A + D F L +D G T +H+A A G A+ L + + LD +++G S
Sbjct: 734 EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793
Query: 483 AFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQF 542
A + H +L+ + + + TPLH CA + + GA+G+
Sbjct: 794 PMHWA-SYTGHEDCLELLLEHSPFSYLEGNPFTPLH-CAVINNQDSTTEMLLGALGAKIV 851
Query: 543 VDLEATNYDGLTPLHCAVIAHNA------VVHELQRNQQPHSPEVQELLLKNKSLVDTIK 596
+A G TPLH A A N + H+ + N H+ + ++
Sbjct: 852 NSRDAK---GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908
Query: 597 CLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA 656
L+ G A ++ TALHLA + + + + L L +NA N+AL +
Sbjct: 909 FLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINAT----NSALQMP 964
Query: 657 ASLQYRLTQLDAVRLLMRKGADPSTRNLENEQP-VHLVPDGPVGEQIRRIL 706
+ R V+ L+ GA + E P + P+ V + + IL
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 68.9 bits (167), Expect = 2e-11
Identities = 77/296 (26%), Positives = 123/296 (41%), Gaps = 50/296 (16%)
Query: 440 KDADG--DTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQ 497
+D +G T LH A R ++ L +H K+ G A + + + +
Sbjct: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA---KDKGGLVPLHNACSYGHYEVAE 734
Query: 498 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
LV GA VN D W TPLH A KG ++ + + K D N DG TPL
Sbjct: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGA------DPTKKNRDGNTPLD 788
Query: 558 CAV------------------IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV------- 592
A + +Q+ P + ++ +N + +
Sbjct: 789 LVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYN 848
Query: 593 --DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGN 650
+ + L++ GA V A+D K G LH AA ++++ L ++ +C++ + A+
Sbjct: 849 NLEVAEYLLEHGADVNAQD-KGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAF--- 904
Query: 651 TALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRIL 706
T LH AA Q TQL A LL+ GADP+ +N E + P+ L + IR +L
Sbjct: 905 TPLHEAA--QKGRTQLCA--LLLAHGADPTMKNQEGQTPLDLA----TADDIRALL 952
Score = 65.9 bits (159), Expect = 1e-10
Identities = 83/296 (28%), Positives = 119/296 (40%), Gaps = 46/296 (15%)
Query: 448 LHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVN 507
LH A GR+ + L + +H D G A + +V L+ GA N
Sbjct: 220 LHFAAGFGRKDVVEHLLQMGANVHARD---DGGLIPLHNACSFGHAEVVSLLLCQGADPN 276
Query: 508 TTDCWGRTPLHVCAEKGHSQV-LQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAV 566
D W TPLH A KG V + +Q GA D N DG + L A + AV
Sbjct: 277 ARDNWNYTPLHEAAIKGKIDVCIVLLQHGA-------DPNIRNTDGKSALDLADPSAKAV 329
Query: 567 V-------HELQRNQQPHSPEVQELLL------------KNKSL--------VDTIKCLI 599
+ L+ + + ++ LL K+ L V ++ L+
Sbjct: 330 LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLL 389
Query: 600 QMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASL 659
Q GA V AKD K G LH A + E+ L L+ +C VNA T LH AAS
Sbjct: 390 QHGADVHAKD-KGGLVPLHNACSYGHYEVTELLLKHGAC---VNAMDLWQFTPLHEAASK 445
Query: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRA 715
+++ LL+ GADP+ N + V + P + E++ KG S+ Q A
Sbjct: 446 N----RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAA 497
Score = 56.2 bits (134), Expect = 1e-07
Identities = 79/332 (23%), Positives = 136/332 (40%), Gaps = 55/332 (16%)
Query: 414 GKSLFQWQVEQEESKLANISQDQFLS--KDADGDTFLHIAVAQ---GRRALSYVLARKMN 468
G SL Q E + +K+ + ++ + +T LH AVA R+ ++ +L RK
Sbjct: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
Query: 469 ALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQV 528
++ K + + VA + +++ L GA++N D G+T LH A GH Q
Sbjct: 550 NVNE---KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQT 606
Query: 529 LQ------------------AIQKGAVGSNQFVD--------------LEATNYDGLTPL 556
+ A Q G Q + LEA+ L +
Sbjct: 607 CRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETV 666
Query: 557 HCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTA 616
+ N +L+ HS + N+ V ++ L+ GA V AKD K G
Sbjct: 667 KQLCSSQNVNCRDLEGR---HSTPLHFAAGYNR--VSVVEYLLHHGADVHAKD-KGGLVP 720
Query: 617 LHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKG 676
LH A + E+ L + + ++ + + T LH AA+ + + +LL++ G
Sbjct: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKF---TPLHEAAA----KGKYEICKLLLKHG 773
Query: 677 ADPSTRNLENEQPVHLVPDGPVGEQIRRILKG 708
ADP+ +N + P+ LV +G I+ +L+G
Sbjct: 774 ADPTKKNRDGNTPLDLVKEGDT--DIQDLLRG 803
Score = 55.1 bits (131), Expect = 2e-07
Identities = 74/272 (27%), Positives = 116/272 (42%), Gaps = 30/272 (11%)
Query: 429 LANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAV 488
LA+ S L+ + D L A + L +L H D ++ + +A
Sbjct: 321 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRK---STPLHLAA 377
Query: 489 AANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEAT 548
N+ IVQ L+ GA V+ D G PLH GH +V + + K N A
Sbjct: 378 GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN------AM 431
Query: 549 NYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAK 608
+ TPLH A + V L + H + + KS VD M E +
Sbjct: 432 DLWQFTPLHEAASKNRVEVCSLLLS---HGADPTLVNCHGKSAVD-------MAPTPELR 481
Query: 609 DRKS----GRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVA-ASLQYRL 663
+R + G + L AA EA+L ++ L L ++F +++ TALH A ASL +
Sbjct: 482 ERLTYEFKGHSLLQ-AAREADLAKVKKTLAL-EIINFKQPQSH--ETALHCAVASLHPKR 537
Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695
Q+ LL+RKGA+ + +N + P+H+ +
Sbjct: 538 KQV--TELLLRKGANVNEKNKDFMTPLHVAAE 567
Score = 30.0 bits (66), Expect = 7.8
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 5/88 (5%)
Query: 42 AAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQP----V 97
AAAP S S AP GS S++ S+SS + + S S G+ P V
Sbjct: 100 AAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGV 159
Query: 98 EPHMGVGRQQRGPFQGV-RVKNSVKELL 124
+G GP GV V +++ELL
Sbjct: 160 SSTAPLGPGAAGPGTGVPAVSGALRELL 187
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 67.8 bits (164), Expect = 3e-11
Identities = 81/257 (31%), Positives = 108/257 (42%), Gaps = 33/257 (12%)
Query: 443 DGDTFLHIAVAQGRRALSYVLARKMNALH--MLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
DG T LH A +G VLA M L LD + G++AF A Q + LV
Sbjct: 123 DGLTLLHCAAQKGHVP---VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLV 179
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAV 560
G N D G T LH+ A +GH VLQ + +G +DLE N +GLT LH A
Sbjct: 180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVD--IG----LDLEEQNAEGLTALHSAA 233
Query: 561 -IAHNAVVHELQRNQQPHSPEVQELLLKNKSLV---------DTIKCLIQMGAAVEAKDR 610
+H V L R V L KN S + D + LI G D
Sbjct: 234 GGSHPDCVQLLLR----AGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDH 289
Query: 611 KSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVR 670
+ G + LHLA L+RL + S VNA T LH+AA ++ D
Sbjct: 290 Q-GASPLHLAVRHNFPALVRLLINSD---SDVNAVDNRQQTPLHLAAEHAWQ----DIAD 341
Query: 671 LLMRKGADPSTRNLENE 687
+L+ G D + R+ + +
Sbjct: 342 MLLIAGVDLNLRDKQGK 358
Score = 58.9 bits (141), Expect = 2e-08
Identities = 67/263 (25%), Positives = 111/263 (42%), Gaps = 37/263 (14%)
Query: 448 LHIAVAQGRRA-LSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQV 506
LH A Q + ++ R++N + H G+ A A A V+ L+ A V
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTR----ARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74
Query: 507 NTTD----------CWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPL 556
+ D C+G L + A GH ++LQ + N + + DGLT L
Sbjct: 75 DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQIL------VNSGAKIHCESKDGLTLL 128
Query: 557 HCAVIAHNA-----VVHELQRNQQPHSPEVQELLLKNKS---LVDTIKCLIQMGAAVEAK 608
HCA + ++ +L+ H ++ + +D + L+ G K
Sbjct: 129 HCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVK 188
Query: 609 DRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDA 668
D K G TALHLAA ++ +++ +++ L NA+ G TALH AA + D
Sbjct: 189 D-KEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE---GLTALHSAAGGSHP----DC 240
Query: 669 VRLLMRKGADPSTRNLENEQPVH 691
V+LL+R G+ + +N +H
Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLH 263
Score = 48.1 bits (113), Expect = 3e-05
Identities = 55/204 (26%), Positives = 89/204 (43%), Gaps = 22/204 (10%)
Query: 440 KDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHN--GQSAFQVAVAANQHLIVQ 497
KD +G+T LH+A +G A VL R ++ LD++E N G +A A + VQ
Sbjct: 188 KDKEGNTALHLAAGRGHMA---VLQRLVDI--GLDLEEQNAEGLTALHSAAGGSHPDCVQ 242
Query: 498 DLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLH 557
L+ G+ VN + LH A G V + + +N ++ G +PLH
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN------VVDHQGASPLH 296
Query: 558 CAVIAHN--AVVHEL-----QRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDR 610
AV HN A+V L N + + L + D L+ G + +D
Sbjct: 297 LAV-RHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRD- 354
Query: 611 KSGRTALHLAAEEANLELIRLFLE 634
K G+TAL +A ++ L+ + ++
Sbjct: 355 KQGKTALAVAVRSNHVSLVDMIIK 378
Score = 37.7 bits (86), Expect = 0.037
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 595 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALH 654
++ L+ GA + + K G T LH AA++ ++ ++ +E ++ + G TA H
Sbjct: 107 LQILVNSGAKIHCES-KDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKL-GRTAFH 164
Query: 655 VAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHL 692
AA QLDA+ L+ G D + ++ E +HL
Sbjct: 165 RAAEHG----QLDALDFLVGSGCDHNVKDKEGNTALHL 198
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 67.4 bits (163), Expect = 4e-11
Identities = 64/241 (26%), Positives = 98/241 (40%), Gaps = 42/241 (17%)
Query: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532
LD+K+ +G+ A VA + Q L + G+ N D TPLH A G+ V +A+
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
Query: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592
+ N N +G TPL L +
Sbjct: 498 CEAGCNVN------IKNREGETPL---------------------------LTASARGYH 524
Query: 593 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 652
D ++CL + GA + A D K G ALHLA +E+I+ L C FV+ + +GNT
Sbjct: 525 DIVECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLS-QGC--FVDYQDRHGNTP 580
Query: 653 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRI-LKGKSI 711
LHVA + + V L + N P+HL + + + +R + L G S+
Sbjct: 581 LHVAC----KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASV 636
Query: 712 Q 712
+
Sbjct: 637 E 637
Score = 40.4 bits (93), Expect = 0.006
Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 3/90 (3%)
Query: 441 DADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLV 500
D DG LH+AV RR V+ ++ +D ++ +G + VA IV L
Sbjct: 541 DKDGHIALHLAV---RRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALC 597
Query: 501 NIGAQVNTTDCWGRTPLHVCAEKGHSQVLQ 530
++ ++ +GRTPLH+ A G V++
Sbjct: 598 EANCNLDISNKYGRTPLHLAANNGILDVVR 627
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 67.0 bits (162), Expect = 6e-11
Identities = 66/229 (28%), Positives = 100/229 (43%), Gaps = 24/229 (10%)
Query: 472 MLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQA 531
+LD +G SA A +V+ LV GA VN D G TPLHV A G+ + +
Sbjct: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
Query: 532 IQK-----GAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL 586
+ AV S+ + L+ D + L A IA V E + + +ELLL
Sbjct: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE------EELLL 206
Query: 587 KNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKA 646
+ +C + GA EA+ ++G +ALH+AA + +E++RL L+ +
Sbjct: 207 HDT------RCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDG-- 258
Query: 647 YNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695
+G T LH AA DA RLL G + ++P L +
Sbjct: 259 -DGWTPLHAAAHWGVE----DACRLLAEHGGGMDSLTHAGQRPCDLADE 302
Score = 43.1 bits (100), Expect = 9e-04
Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 604 AVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRL 663
AV G +ALH A + NLE++R +E + VN G T LHVAAS Y
Sbjct: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGAT---VNQADNEGWTPLHVAASCGY-- 146
Query: 664 TQLDAVRLLMRKGADPSTRNLENEQPVHL 692
LD R L+ GA+ + N + + P+ L
Sbjct: 147 --LDIARYLLSHGANIAAVNSDGDLPLDL 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,000,455
Number of Sequences: 37866
Number of extensions: 1483114
Number of successful extensions: 7292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 5180
Number of HSP's gapped (non-prelim): 1274
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.