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Search of human proteins with 13654239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
(922 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 1897 0.0
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 1078 0.0
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 1072 0.0
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 758 0.0
gi|222352088 neural precursor cell expressed, developmentally do... 518 e-147
gi|222352086 neural precursor cell expressed, developmentally do... 518 e-147
gi|114520609 neural precursor cell expressed, developmentally do... 513 e-145
gi|114520607 neural precursor cell expressed, developmentally do... 513 e-145
gi|222352183 neural precursor cell expressed, developmentally do... 512 e-145
gi|222352084 neural precursor cell expressed, developmentally do... 512 e-145
gi|222352082 neural precursor cell expressed, developmentally do... 512 e-145
gi|21361472 neural precursor cell expressed, developmentally dow... 511 e-144
gi|222352090 neural precursor cell expressed, developmentally do... 511 e-144
gi|222352094 neural precursor cell expressed, developmentally do... 504 e-142
gi|222352092 neural precursor cell expressed, developmentally do... 504 e-142
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 473 e-133
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 452 e-127
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 447 e-125
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 378 e-104
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 377 e-104
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 325 1e-88
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 280 3e-75
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 201 2e-51
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 201 2e-51
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 201 2e-51
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 199 1e-50
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 182 2e-45
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 171 4e-42
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 171 4e-42
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 170 6e-42
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 1897 bits (4914), Expect = 0.0
Identities = 922/922 (100%), Positives = 922/922 (100%)
Query: 1 MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSS 60
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSS
Sbjct: 1 MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSS 60
Query: 61 NPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLK 120
NPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLK
Sbjct: 61 NPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLK 120
Query: 121 LSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTAR 180
LSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTAR
Sbjct: 121 LSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTAR 180
Query: 181 LAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADD 240
LAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADD
Sbjct: 181 LAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADD 240
Query: 241 TVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS 300
TVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS
Sbjct: 241 TVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTS 300
Query: 301 AELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKD 360
AELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKD
Sbjct: 301 AELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKD 360
Query: 361 PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNF 420
PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNF
Sbjct: 361 PHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNF 420
Query: 421 EQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTK 480
EQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTK
Sbjct: 421 EQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTK 480
Query: 481 TTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ 540
TTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ
Sbjct: 481 TTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQ 540
Query: 541 IAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIF 600
IAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIF
Sbjct: 541 IAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIF 600
Query: 601 RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFI 660
RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFI
Sbjct: 601 RGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFI 660
Query: 661 GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL 720
GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL
Sbjct: 661 GRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGL 720
Query: 721 EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF 780
EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF
Sbjct: 721 EMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGF 780
Query: 781 NEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN 840
NEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN
Sbjct: 781 NEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDN 840
Query: 841 EVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYK 900
EVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYK
Sbjct: 841 EVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYK 900
Query: 901 SYEQLKEKLLFAIEETEGFGQE 922
SYEQLKEKLLFAIEETEGFGQE
Sbjct: 901 SYEQLKEKLLFAIEETEGFGQE 922
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 1078 bits (2787), Expect = 0.0
Identities = 552/910 (60%), Positives = 658/910 (72%), Gaps = 72/910 (7%)
Query: 19 QLQVTVSSAKLKR-KKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTT 77
QLQ+TV SAKLK KKNWFG + Y EV VDG+ KT K +++++PKW + LTV VTP +
Sbjct: 19 QLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSK 78
Query: 78 LEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGELTV 137
L F+VWSH+TLK+D LLG A +D+ + L +N KLE V L+L +K G+L++
Sbjct: 79 LHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLG-GDKEPTETIGDLSI 137
Query: 138 VLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTST 197
LDGL +E E +TN ++ + +N D E T E +N
Sbjct: 138 CLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRR---- 193
Query: 198 LVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASV 257
V+G+N+PS S +P P P S P T P ASV
Sbjct: 194 ----------VSGNNSPSL-SNGGFKPSRPPRP----SRPPPPT---------PRRPASV 229
Query: 258 TGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSN 317
G+P +A S + S+T PP T++ N +TS ++ P T +
Sbjct: 230 NGSP-----SATSESDGSSTGSLPP-----TNTNTNTSEGATSG--------LIIPLTIS 271
Query: 318 SRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTW 377
S +P ++PV Q LP GWEQR D HGR YYVDH + TTW
Sbjct: 272 GGSGP--------RP---LNPVTQAP-------LPPGWEQRVDQHGRVYYVDHVEKRTTW 313
Query: 378 ERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQF 437
+RP+PLPPGWERRVD+ R+YYVDH TRTTTWQRPT+ESVRN+EQWQ QR+QLQGAMQQF
Sbjct: 314 DRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQF 373
Query: 438 NQRYLYS-----ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGL 492
NQR++Y A+ + E DP GPLPPGWEKR DS RVYFVNHNT+ TQWEDPR+QG
Sbjct: 374 NQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ 433
Query: 493 QNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLA 552
NE+PLPEGWE+R+T +G+ YFVDHN RTTT+ DPR GKS++ G PQIAY R F+ K+
Sbjct: 434 LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNG-PQIAYVRDFKAKVQ 492
Query: 553 HFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLA 612
+FR+ CQ A+P H+KI V+R+TLFEDSFQQIM+ P DLRRRL+VIF GEEGLDYGG+A
Sbjct: 493 YFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVA 552
Query: 613 REWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGK 672
REWFFLLSHEVLNPMYCLFEYAGK+NYCLQINPAS INPDHL YF FIGRFIAMALFHGK
Sbjct: 553 REWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGK 612
Query: 673 FIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILG 732
FIDTGFSLPFYKR+L+K + +KDLESID EFYNSLIW+++NNIEEC LEMYFSVD EILG
Sbjct: 613 FIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILG 672
Query: 733 KVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYF 792
++ SHDLK G NILVTEENK+EYI ++ EWR SRGV+EQT+AF +GFNE++P Q+LQYF
Sbjct: 673 EIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYF 732
Query: 793 DEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTG 852
D KELEV+LCGMQE+DL DWQR+ +YRHY R SKQI+WFWQFVKE DNE RMRLLQFVTG
Sbjct: 733 DAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTG 792
Query: 853 TCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 912
TCRLP+GGFA+LMGSNGPQKFCIEKVGK+ WLPRSHTCFNRLDLPPYKSYEQLKEKLLFA
Sbjct: 793 TCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
Query: 913 IEETEGFGQE 922
IEETEGFGQE
Sbjct: 853 IEETEGFGQE 862
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 1072 bits (2773), Expect = 0.0
Identities = 551/919 (59%), Positives = 657/919 (71%), Gaps = 82/919 (8%)
Query: 19 QLQVTVSSAKLKRKKNWFGTAIYTEVVVDG---EITKTAKSSSSSNPKWDEQLTVNVTPQ 75
QL + V SAK K Y EV VDG E KT K SS W+E + +NVT Q
Sbjct: 19 QLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQ 78
Query: 76 TTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGEL 135
+ L+ +VWS TL+ + LLG A+++L L + K+E ++ L L ENK + GEL
Sbjct: 79 SHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGEL 137
Query: 136 TVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPT 195
T+ LDG ++ N+ N G AL + + +R ++ AV N H P
Sbjct: 138 TIFLDGPTVDLGNVPN------------GSALTDGSQLPSRDSSGTAVAPEN---RHQPP 182
Query: 196 STLVQN-----------SCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNG 244
ST S + G+ +P + S+ KN+ S A+ TVN
Sbjct: 183 STNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGH-----SGLANGTVND 237
Query: 245 ESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEI-LTSSENNECIPSTSAEL 303
E ++ + SV G V PP + +T + N +P+ +
Sbjct: 238 EPTTATDPEEPSVVG------------------VTSPPAAPLSVTPNPNTTSLPAPATPA 279
Query: 304 ESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHG 363
E E EP TS ++ A A PD LP+GWEQR+ P+G
Sbjct: 280 EGE-----EPSTSGTQQLPAAAQA----PDA----------------LPAGWEQRELPNG 314
Query: 364 RTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQW 423
R YYVDHNT+TTTWERP LPPGWE+R D R R YYVDHNTRTTTWQRPT E VRN+EQW
Sbjct: 315 RVYYVDHNTKTTTWERP--LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQW 372
Query: 424 QSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQ 483
QSQRNQLQGAMQ F+QR+LY +S + ++DP GPLPPGWEKR D+ RVY+VNHNT+TTQ
Sbjct: 373 QSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDN-GRVYYVNHNTRTTQ 431
Query: 484 WEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAY 543
WEDPRTQG+ E LP GWE++YT EGVRYFVDHNTRTTTFKDPR G S TK G AY
Sbjct: 432 WEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAY 491
Query: 544 ERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGE 603
+R FRWK FR+LC SNALPSHVKI+VSRQTLFEDSFQQIM +KPYDLRRRLY+I RGE
Sbjct: 492 DRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGE 551
Query: 604 EGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRF 663
EGLDYGG+AREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS+INPDHL+YF FIGRF
Sbjct: 552 EGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRF 611
Query: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
IAMAL+HGKFIDTGF+LPFYKRML+K+ T+KDLESID EFYNS++WI++NN+EECGLE+Y
Sbjct: 612 IAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELY 671
Query: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
F DMEILGKVT+H+LK GG +I VTEENK+EYI L+T+WRF+RGV+EQTKAFLDGFNEV
Sbjct: 672 FIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEV 731
Query: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVR 843
PL+WL+YFDEKELE+MLCGMQE+D++DWQ++T+YRHYT+NSKQI WFWQ VKE DNE R
Sbjct: 732 APLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKR 791
Query: 844 MRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYE 903
+RLLQFVTGTCRLP+GGFAEL+GSNGPQKFCI+KVGK+TWLPRSHTCFNRLDLPPYKSYE
Sbjct: 792 IRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYE 851
Query: 904 QLKEKLLFAIEETEGFGQE 922
QL+EKLL+AIEETEGFGQE
Sbjct: 852 QLREKLLYAIEETEGFGQE 870
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 758 bits (1958), Expect = 0.0
Identities = 349/428 (81%), Positives = 395/428 (92%)
Query: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHF 554
E LP GWE++YT EGVRYFVDHNTRTTTFKDPR G S TK G AY+R FRWK F
Sbjct: 4 EPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQF 63
Query: 555 RYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLARE 614
R+LC SNALPSHVKI+VSRQTLFEDSFQQIM +KPYDLRRRLY+I RGEEGLDYGG+ARE
Sbjct: 64 RFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIARE 123
Query: 615 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674
WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAS+INPDHL+YF FIGRFIAMAL+HGKFI
Sbjct: 124 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFI 183
Query: 675 DTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKV 734
DTGF+LPFYKRML+K+ T+KDLESID EFYNS++WI++NN+EECGLE+YF DMEILGKV
Sbjct: 184 DTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV 243
Query: 735 TSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDE 794
T+H+LK GG +I VTEENK+EYI L+T+WRF+RGV+EQTKAFLDGFNEV PL+WL+YFDE
Sbjct: 244 TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDE 303
Query: 795 KELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTC 854
KELE+MLCGMQE+D++DWQ++T+YRHYT+NSKQI WFWQ VKE DNE R+RLLQFVTGTC
Sbjct: 304 KELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTC 363
Query: 855 RLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIE 914
RLP+GGFAEL+GSNGPQKFCI+KVGK+TWLPRSHTCFNRLDLPPYKSYEQL+EKLL+AIE
Sbjct: 364 RLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIE 423
Query: 915 ETEGFGQE 922
ETEGFGQE
Sbjct: 424 ETEGFGQE 431
Score = 45.4 bits (106), Expect = 2e-04
Identities = 18/32 (56%), Positives = 23/32 (71%)
Query: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP 382
LP GWE + G Y+VDHNTRTTT++ P+P
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38
Score = 42.4 bits (98), Expect = 0.002
Identities = 20/36 (55%), Positives = 24/36 (66%), Gaps = 2/36 (5%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQ--RPTMES 416
LPPGWE + Y+VDHNTRTTT++ RP ES
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFES 42
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 518 bits (1335), Expect = e-147
Identities = 339/946 (35%), Positives = 495/946 (52%), Gaps = 114/946 (12%)
Query: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101
TKT K + NPKW+E+ V P L F+V+ L D LG+ + L
Sbjct: 55 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 112
Query: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151
K LL RVK +LK++ KNG Q E + D + E + +
Sbjct: 113 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 171
Query: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211
S+ + + L E R T ++++ T+ + S D
Sbjct: 172 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 226
Query: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268
N +Q AA + + L EP++ G+ T +SEE
Sbjct: 227 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 273
Query: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328
++ + + PP +S + P +E E R + PD++ + SS +
Sbjct: 274 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 326
Query: 329 SRQPDGCM--DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP-LPP 385
S + C D V +Q G+ + P+G + G + T + + P LP
Sbjct: 327 SSRLRSCSVTDAVAEQ-GHLPPPSAPAGRARSSTVTGG----EEPTPSVAYVHTTPGLPS 381
Query: 386 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ---------------- 429
GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 382 GWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSS 441
Query: 430 --------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDS 468
L+GA +R + ++ + + PY LPPGWE R+
Sbjct: 442 PTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAP 501
Query: 469 TDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDH 517
R +F++HNTKTT WEDPR + + PLP GWE R +G +++DH
Sbjct: 502 NGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDH 561
Query: 518 NTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTL 576
N++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R +
Sbjct: 562 NSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNI 619
Query: 577 FEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAG 635
FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+
Sbjct: 620 FEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSA 679
Query: 636 KNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIK 694
+NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+
Sbjct: 680 TDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN 739
Query: 695 DLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKD 754
D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT ENK
Sbjct: 740 DMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKR 797
Query: 755 EYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQR 814
EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW++
Sbjct: 798 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 857
Query: 815 NTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKF 873
+++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F
Sbjct: 858 HSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLF 917
Query: 874 CIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 918 TIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 518 bits (1335), Expect = e-147
Identities = 339/946 (35%), Positives = 495/946 (52%), Gaps = 114/946 (12%)
Query: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101
TKT K + NPKW+E+ V P L F+V+ L D LG+ + L
Sbjct: 63 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
Query: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151
K LL RVK +LK++ KNG Q E + D + E + +
Sbjct: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 179
Query: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211
S+ + + L E R T ++++ T+ + S D
Sbjct: 180 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 234
Query: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268
N +Q AA + + L EP++ G+ T +SEE
Sbjct: 235 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 281
Query: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328
++ + + PP +S + P +E E R + PD++ + SS +
Sbjct: 282 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 334
Query: 329 SRQPDGCM--DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP-LPP 385
S + C D V +Q G+ + P+G + G + T + + P LP
Sbjct: 335 SSRLRSCSVTDAVAEQ-GHLPPPSAPAGRARSSTVTGG----EEPTPSVAYVHTTPGLPS 389
Query: 386 GWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ---------------- 429
GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 390 GWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSS 449
Query: 430 --------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDS 468
L+GA +R + ++ + + PY LPPGWE R+
Sbjct: 450 PTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAP 509
Query: 469 TDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDH 517
R +F++HNTKTT WEDPR + + PLP GWE R +G +++DH
Sbjct: 510 NGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDH 569
Query: 518 NTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTL 576
N++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R +
Sbjct: 570 NSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNI 627
Query: 577 FEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAG 635
FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+
Sbjct: 628 FEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSA 687
Query: 636 KNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIK 694
+NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+
Sbjct: 688 TDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLN 747
Query: 695 DLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKD 754
D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT ENK
Sbjct: 748 DMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKR 805
Query: 755 EYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQR 814
EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW++
Sbjct: 806 EYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQ 865
Query: 815 NTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKF 873
+++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F
Sbjct: 866 HSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLF 925
Query: 874 CIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 926 TIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 513 bits (1321), Expect = e-145
Identities = 263/557 (47%), Positives = 368/557 (66%), Gaps = 30/557 (5%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRN----QLQGAMQQFN 438
LPPGWE + D+R R YYVDHN+RTTTW +PT+++ Q S ++ Q Q +
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 439 QRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ-------- 490
Q+ + + G LP GWE R R +F++HNTKTT WEDPR +
Sbjct: 410 QQVTQPSEI------EQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGK 463
Query: 491 ---GLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERG 546
N+ PLP GWE R +G ++++HN + T ++DPR ++T GP + Y R
Sbjct: 464 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT--GPAVPYSRD 521
Query: 547 FRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEE 604
++ K FR L + N +P+ ++ + R T+ EDS+++IM +K D L+ RL++ F GE+
Sbjct: 522 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 581
Query: 605 GLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRF 663
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHLSYF FIGR
Sbjct: 582 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 641
Query: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
MA++HGK +D F PFYK ML K +T+ D+ES+D+E+YNSL WI +N+ E L++
Sbjct: 642 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 699
Query: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
F +D E+ G+ H+LK GGS I+VT +NK EYI L+ +WRF +Q+Q AF +GF E+
Sbjct: 700 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 759
Query: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEV 842
+P ++ FDE ELE+++CG+ +VD+ DW+ +T Y++ Y+ N + I WFW+ V D+E
Sbjct: 760 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 819
Query: 843 RMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY 902
R+RLLQFVTGT R+P+ GFAEL GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 820 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 879
Query: 903 EQLKEKLLFAIEETEGF 919
E+L +KL AIE T+GF
Sbjct: 880 EELWDKLQMAIENTQGF 896
Score = 90.9 bits (224), Expect = 5e-18
Identities = 71/274 (25%), Positives = 112/274 (40%), Gaps = 38/274 (13%)
Query: 175 ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARP---KNTPAPK 231
A TT R E T +DN ++S ++ D +Q P N P
Sbjct: 243 AFTTRRQISEETESVDNR-------ESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPT 295
Query: 232 PLASE-PADDTVNGESSSFAPTDNASVTGT-----PVVSEENALSPNCTSTTVEDPPVQE 285
LA E A T+ G S+ P +++ + EE P T+ PP E
Sbjct: 296 HLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWE 355
Query: 286 ILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGN 345
++ + + ++ S+ +S+ +A + D +Q +
Sbjct: 356 EKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQP 415
Query: 346 ANTET--LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------------PL 383
+ E LP GWE R P+GR +++DHNT+TTTWE P+ PL
Sbjct: 416 SEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPL 475
Query: 384 PPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESV 417
PPGWE R R++Y++HN + T W+ P +E+V
Sbjct: 476 PPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 509
Score = 67.8 bits (164), Expect = 4e-11
Identities = 69/265 (26%), Positives = 100/265 (37%), Gaps = 62/265 (23%)
Query: 310 ILEPDTSNSRSSSAFEAAKSRQP--DGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYY 367
+L P + SR + P G D +Q+ E L GW P +
Sbjct: 130 VLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQA-----EELEPGWVVLDQPDAACHL 184
Query: 368 VDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQR 427
+ P PLPPGWE R D R YYV+H +R T W+RPT + N ++
Sbjct: 185 QQQ-------QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQD--NLTDAENGN 235
Query: 428 NQLQGAMQQFNQRYLYS----------------------ASMLAAENDPYGP------LP 459
QLQ A + F R S A+M + + P P +P
Sbjct: 236 IQLQ-AQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVP 294
Query: 460 PGWEKRVDSTDRVY----------FVNHNTKT------TQWEDPRTQGL-QNEEPLPEGW 502
+ +++ ++ NH+++ T E P L LP GW
Sbjct: 295 THLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGW 354
Query: 503 EIRYTREGVRYFVDHNTRTTTFKDP 527
E + G Y+VDHN+RTTT+ P
Sbjct: 355 EEKQDERGRSYYVDHNSRTTTWTKP 379
Score = 39.7 bits (91), Expect = 0.013
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 490 QGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFK--DPRNGKSSVTKGGPQIAYERGF 547
Q Q PLP GWE R G Y+V+H +R T +K P++ + G Q+ +R F
Sbjct: 185 QQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAF 244
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 513 bits (1321), Expect = e-145
Identities = 263/557 (47%), Positives = 368/557 (66%), Gaps = 30/557 (5%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRN----QLQGAMQQFN 438
LPPGWE + D+R R YYVDHN+RTTTW +PT+++ Q S ++ Q Q +
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 439 QRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ-------- 490
Q+ + + G LP GWE R R +F++HNTKTT WEDPR +
Sbjct: 757 QQVTQPSEI------EQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGK 810
Query: 491 ---GLQNE-EPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERG 546
N+ PLP GWE R +G ++++HN + T ++DPR ++T GP + Y R
Sbjct: 811 TSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAIT--GPAVPYSRD 868
Query: 547 FRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEE 604
++ K FR L + N +P+ ++ + R T+ EDS+++IM +K D L+ RL++ F GE+
Sbjct: 869 YKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEK 928
Query: 605 GLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRF 663
GLDYGG+AREWFFL+S E+ NP Y LFEY+ +NY LQINP S + N DHLSYF FIGR
Sbjct: 929 GLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRV 988
Query: 664 IAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMY 723
MA++HGK +D F PFYK ML K +T+ D+ES+D+E+YNSL WI +N+ E L++
Sbjct: 989 AGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE--LDLR 1046
Query: 724 FSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEV 783
F +D E+ G+ H+LK GGS I+VT +NK EYI L+ +WRF +Q+Q AF +GF E+
Sbjct: 1047 FIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFEL 1106
Query: 784 VPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEV 842
+P ++ FDE ELE+++CG+ +VD+ DW+ +T Y++ Y+ N + I WFW+ V D+E
Sbjct: 1107 IPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEK 1166
Query: 843 RMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSY 902
R+RLLQFVTGT R+P+ GFAEL GSNGPQ F +E+ G LPR+HTCFNRLDLPPY+S+
Sbjct: 1167 RIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESF 1226
Query: 903 EQLKEKLLFAIEETEGF 919
E+L +KL AIE T+GF
Sbjct: 1227 EELWDKLQMAIENTQGF 1243
Score = 90.9 bits (224), Expect = 5e-18
Identities = 71/274 (25%), Positives = 112/274 (40%), Gaps = 38/274 (13%)
Query: 175 ARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARP---KNTPAPK 231
A TT R E T +DN ++S ++ D +Q P N P
Sbjct: 590 AFTTRRQISEETESVDNR-------ESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPT 642
Query: 232 PLASE-PADDTVNGESSSFAPTDNASVTGT-----PVVSEENALSPNCTSTTVEDPPVQE 285
LA E A T+ G S+ P +++ + EE P T+ PP E
Sbjct: 643 HLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWE 702
Query: 286 ILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGN 345
++ + + ++ S+ +S+ +A + D +Q +
Sbjct: 703 EKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQP 762
Query: 346 ANTET--LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------------PL 383
+ E LP GWE R P+GR +++DHNT+TTTWE P+ PL
Sbjct: 763 SEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPL 822
Query: 384 PPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESV 417
PPGWE R R++Y++HN + T W+ P +E+V
Sbjct: 823 PPGWEERTHTDGRIFYINHNIKRTQWEDPRLENV 856
Score = 67.0 bits (162), Expect = 8e-11
Identities = 56/195 (28%), Positives = 81/195 (41%), Gaps = 48/195 (24%)
Query: 378 ERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQF 437
+ P PLPPGWE R D R YYV+H +R T W+RPT + N ++ QLQ A + F
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQD--NLTDAENGNIQLQ-AQRAF 591
Query: 438 NQRYLYS----------------------ASMLAAENDPYGP------LPPGWEKRVDST 469
R S A+M + + P P +P + +++
Sbjct: 592 TTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNAR 651
Query: 470 DRVY----------FVNHNTKT------TQWEDPRTQGL-QNEEPLPEGWEIRYTREGVR 512
++ NH+++ T E P L LP GWE + G
Sbjct: 652 LTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRS 711
Query: 513 YFVDHNTRTTTFKDP 527
Y+VDHN+RTTT+ P
Sbjct: 712 YYVDHNSRTTTWTKP 726
Score = 51.2 bits (121), Expect = 4e-06
Identities = 22/47 (46%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Query: 444 SASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ 490
+A L + +P PLPPGWE+R D R Y+VNH ++ TQW+ P Q
Sbjct: 527 AACHLQQQQEP-SPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQ 572
Score = 39.7 bits (91), Expect = 0.013
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 490 QGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFK--DPRNGKSSVTKGGPQIAYERGF 547
Q Q PLP GWE R G Y+V+H +R T +K P++ + G Q+ +R F
Sbjct: 532 QQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAF 591
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 512 bits (1318), Expect = e-145
Identities = 288/712 (40%), Positives = 415/712 (58%), Gaps = 71/712 (9%)
Query: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
Query: 323 AFEAAKSRQPDGCM--DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
+ S + C D V +Q G+ + P+G + G + T + +
Sbjct: 208 LIQREPSSRLRSCSVTDAVAEQ-GHLPPPSAPAGRARSSTVTGG----EEPTPSVAYVHT 262
Query: 381 QP-LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ---------- 429
P LP GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 263 TPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRR 322
Query: 430 --------------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGW 462
L+GA +R + ++ + + PY LPPGW
Sbjct: 323 PRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 463 EKRVDSTDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGV 511
E R+ R +F++HNTKTT WEDPR + + PLP GWE R +G
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 512 RYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKIN 570
+++DHN++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 500
Query: 571 VSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYC 629
+ R +FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 630 LFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS 688
LFEY+ +NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 689 KKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILV 748
K++T+ D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 749 TEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVD 808
T ENK EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 809 LADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGS 867
+ DW+++++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GS
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 868 NGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
NGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 799 NGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Query: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
Score = 57.8 bits (138), Expect = 5e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 512 bits (1318), Expect = e-145
Identities = 288/712 (40%), Positives = 415/712 (58%), Gaps = 71/712 (9%)
Query: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
Query: 323 AFEAAKSRQPDGCM--DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
+ S + C D V +Q G+ + P+G + G + T + +
Sbjct: 208 LIQREPSSRLRSCSVTDAVAEQ-GHLPPPSAPAGRARSSTVTGG----EEPTPSVAYVHT 262
Query: 381 QP-LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ---------- 429
P LP GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 263 TPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRR 322
Query: 430 --------------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGW 462
L+GA +R + ++ + + PY LPPGW
Sbjct: 323 PRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 463 EKRVDSTDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGV 511
E R+ R +F++HNTKTT WEDPR + + PLP GWE R +G
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 512 RYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKIN 570
+++DHN++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 500
Query: 571 VSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYC 629
+ R +FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 630 LFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS 688
LFEY+ +NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 689 KKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILV 748
K++T+ D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 749 TEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVD 808
T ENK EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 809 LADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGS 867
+ DW+++++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GS
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 868 NGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
NGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 799 NGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Query: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
Score = 57.8 bits (138), Expect = 5e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 512 bits (1318), Expect = e-145
Identities = 288/712 (40%), Positives = 415/712 (58%), Gaps = 71/712 (9%)
Query: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
Query: 323 AFEAAKSRQPDGCM--DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
+ S + C D V +Q G+ + P+G + G + T + +
Sbjct: 208 LIQREPSSRLRSCSVTDAVAEQ-GHLPPPSAPAGRARSSTVTGG----EEPTPSVAYVHT 262
Query: 381 QP-LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ---------- 429
P LP GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 263 TPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRR 322
Query: 430 --------------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGW 462
L+GA +R + ++ + + PY LPPGW
Sbjct: 323 PRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGW 382
Query: 463 EKRVDSTDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGV 511
E R+ R +F++HNTKTT WEDPR + + PLP GWE R +G
Sbjct: 383 EMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGR 442
Query: 512 RYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKIN 570
+++DHN++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++
Sbjct: 443 TFYIDHNSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK 500
Query: 571 VSRQTLFEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYC 629
+ R +FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y
Sbjct: 501 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG 560
Query: 630 LFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS 688
LFEY+ +NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML
Sbjct: 561 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG 620
Query: 689 KKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILV 748
K++T+ D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+V
Sbjct: 621 KQITLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMV 678
Query: 749 TEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVD 808
T ENK EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD
Sbjct: 679 TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 738
Query: 809 LADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGS 867
+ DW+++++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GS
Sbjct: 739 VNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 798
Query: 868 NGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
NGPQ F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 799 NGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Query: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
Score = 57.8 bits (138), Expect = 5e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 511 bits (1316), Expect = e-144
Identities = 338/943 (35%), Positives = 489/943 (51%), Gaps = 128/943 (13%)
Query: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101
TKT K + NPKW+E+ V P L F+V+ L D LG+ + L
Sbjct: 63 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 120
Query: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151
K LL RVK +LK++ KNG Q E + D + E + +
Sbjct: 121 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 179
Query: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211
S+ + + L E R T ++++ T+ + S D
Sbjct: 180 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 234
Query: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268
N +Q AA + + L EP++ G+ T +SEE
Sbjct: 235 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 281
Query: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328
++ + + PP +S + P +E E R + PD++ + SS +
Sbjct: 282 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 334
Query: 329 SRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWE 388
S + C + T+ + EQ P YV H T LP GWE
Sbjct: 335 SSRLRSC----------SVTDAVA---EQGHLPPPSVAYV-HTT--------PGLPSGWE 372
Query: 389 RRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ------------------- 429
R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 373 ERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTV 432
Query: 430 -----LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDSTDR 471
L+GA +R + ++ + + PY LPPGWE R+ R
Sbjct: 433 TLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGR 492
Query: 472 VYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTR 520
+F++HNTKTT WEDPR + + PLP GWE R +G +++DHN++
Sbjct: 493 PFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSK 552
Query: 521 TTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFED 579
T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R +FE+
Sbjct: 553 ITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEE 610
Query: 580 SFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNN 638
S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +N
Sbjct: 611 SYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDN 670
Query: 639 YCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLE 697
Y LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+ D+E
Sbjct: 671 YTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDME 730
Query: 698 SIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYI 757
S+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT ENK EYI
Sbjct: 731 SVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYI 788
Query: 758 GLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTV 817
L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++
Sbjct: 789 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSI 848
Query: 818 YRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIE 876
Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE
Sbjct: 849 YKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 908
Query: 877 KVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 909 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 511 bits (1316), Expect = e-144
Identities = 338/943 (35%), Positives = 489/943 (51%), Gaps = 128/943 (13%)
Query: 51 TKTAKSSSSSNPKWDEQLTVNVTPQT-TLEFQVWSHRTLKADALLGKATIDL-------- 101
TKT K + NPKW+E+ V P L F+V+ L D LG+ + L
Sbjct: 55 TKTIKKTL--NPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDP 112
Query: 102 --------KQALLIHNRKLERVKE--QLKLSLENKNGIAQTGELTVVLDGLVIEQENITN 151
K LL RVK +LK++ KNG Q E + D + E + +
Sbjct: 113 TMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNG-GQDEENSDQRDDMEHGWEVVDS 171
Query: 152 CSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGD 211
S+ + + L E R T ++++ T+ + S D
Sbjct: 172 NDSASQHQEELPPPPLPPGWEEKVDNLGR-----TYYVNHNNRTTQWHRPSLMDVSSESD 226
Query: 212 NTPSSPSQVAARPK---NTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENA 268
N +Q AA + + L EP++ G+ T +SEE
Sbjct: 227 NNIRQINQEAAHRRFRSRRHISEDLEPEPSE---GGDVPEPWET----------ISEEVN 273
Query: 269 LSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK 328
++ + + PP +S + P +E E R + PD++ + SS +
Sbjct: 274 IAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSSLIQREP 326
Query: 329 SRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWE 388
S + C + T+ + EQ P YV H T LP GWE
Sbjct: 327 SSRLRSC----------SVTDAVA---EQGHLPPPSVAYV-HTT--------PGLPSGWE 364
Query: 389 RRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ------------------- 429
R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 365 ERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTV 424
Query: 430 -----LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKRVDSTDR 471
L+GA +R + ++ + + PY LPPGWE R+ R
Sbjct: 425 TLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGR 484
Query: 472 VYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYFVDHNTR 520
+F++HNTKTT WEDPR + + PLP GWE R +G +++DHN++
Sbjct: 485 PFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSK 544
Query: 521 TTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSRQTLFED 579
T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R +FE+
Sbjct: 545 ITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEE 602
Query: 580 SFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNN 638
S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFEY+ +N
Sbjct: 603 SYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDN 662
Query: 639 YCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLE 697
Y LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++T+ D+E
Sbjct: 663 YTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDME 722
Query: 698 SIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYI 757
S+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT ENK EYI
Sbjct: 723 SVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYI 780
Query: 758 GLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTV 817
L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ DW+++++
Sbjct: 781 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSI 840
Query: 818 YRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIE 876
Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGPQ F IE
Sbjct: 841 YKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE 900
Query: 877 KVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 901 QWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 504 bits (1299), Expect = e-142
Identities = 287/709 (40%), Positives = 409/709 (57%), Gaps = 85/709 (11%)
Query: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
Query: 323 AFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP 382
+ S + C + T+ + EQ P YV H T
Sbjct: 208 LIQREPSSRLRSC----------SVTDAVA---EQGHLPPPSVAYV-HTT--------PG 245
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ------------- 429
LP GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 430 -----------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKR 465
L+GA +R + ++ + + PY LPPGWE R
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 466 VDSTDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYF 514
+ R +F++HNTKTT WEDPR + + PLP GWE R +G ++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 425
Query: 515 VDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSR 573
+DHN++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R
Sbjct: 426 IDHNSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHR 483
Query: 574 QTLFEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFE 632
+FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFE
Sbjct: 484 NNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFE 543
Query: 633 YAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKL 691
Y+ +NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++
Sbjct: 544 YSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQI 603
Query: 692 TIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEE 751
T+ D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT E
Sbjct: 604 TLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNE 661
Query: 752 NKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLAD 811
NK EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ D
Sbjct: 662 NKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVND 721
Query: 812 WQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGP 870
W+++++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGP
Sbjct: 722 WRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGP 781
Query: 871 QKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
Q F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 782 QLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Query: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
Score = 57.8 bits (138), Expect = 5e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 504 bits (1299), Expect = e-142
Identities = 287/709 (40%), Positives = 409/709 (57%), Gaps = 85/709 (11%)
Query: 263 VSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSS 322
+SEE ++ + + PP +S + P +E E R + PD++ + SS
Sbjct: 155 ISEEVNIAGDSLGLALPPPP------ASPGSRTSPQELSE-ELSRRLQITPDSNGEQFSS 207
Query: 323 AFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP 382
+ S + C + T+ + EQ P YV H T
Sbjct: 208 LIQREPSSRLRSC----------SVTDAVA---EQGHLPPPSVAYV-HTT--------PG 245
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQ------------- 429
LP GWE R D + R YYV+HN RTTTW RP M+ + + +
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 430 -----------LQGAMQQFNQRYLYS--ASMLAAENDPYGP-----------LPPGWEKR 465
L+GA +R + ++ + + PY LPPGWE R
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 466 VDSTDRVYFVNHNTKTTQWEDPRTQ-----------GLQNEEPLPEGWEIRYTREGVRYF 514
+ R +F++HNTKTT WEDPR + + PLP GWE R +G ++
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFY 425
Query: 515 VDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNA-LPSHVKINVSR 573
+DHN++ T ++DPR ++T GP + Y R F+ K +FR + A +P+ ++ + R
Sbjct: 426 IDHNSKITQWEDPRLQNPAIT--GPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHR 483
Query: 574 QTLFEDSFQQIMALKPYD-LRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFE 632
+FE+S+++IM++K D L+ RL++ F E+GLDYGG+AREWFFLLS E+ NP Y LFE
Sbjct: 484 NNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFE 543
Query: 633 YAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKL 691
Y+ +NY LQINP S + N DHLSYF FIGR +A+FHGK +D F PFYK ML K++
Sbjct: 544 YSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQI 603
Query: 692 TIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEE 751
T+ D+ES+D+E+YNSL WI +N+ E L++ F +D E G+ DLK GS I+VT E
Sbjct: 604 TLNDMESVDSEYYNSLKWILENDPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNE 661
Query: 752 NKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLAD 811
NK EYI L+ +WRF VQ+Q AFL+GF E++P+ ++ FDE ELE+++CG+ +VD+ D
Sbjct: 662 NKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVND 721
Query: 812 WQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGP 870
W+++++Y++ Y N I WFW+ V D E R+RLLQFVTGT R+P+ GFAEL GSNGP
Sbjct: 722 WRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGP 781
Query: 871 QKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
Q F IE+ G LPR+HTCFNRLDLPPY+++E L+EKLL A+E +GF
Sbjct: 782 QLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 67.8 bits (164), Expect = 4e-11
Identities = 39/111 (35%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 356 EQRKDPHGRTYYVDHNTRTTTWER---PQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRP 412
+QR D VD N + + P PLPPGWE +VD+ R YYV+HN RTT W RP
Sbjct: 44 DQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Query: 413 TMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWE 463
++ V + ++ + A ++F R S L E G +P WE
Sbjct: 104 SLMDVSSESDNNIRQINQEAAHRRFRSRRHISED-LEPEPSEGGDVPEPWE 153
Score = 57.8 bits (138), Expect = 5e-08
Identities = 23/45 (51%), Positives = 30/45 (66%)
Query: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNE 495
E P PLPPGWE++VD+ R Y+VNHN +TTQW P + +E
Sbjct: 67 EELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSE 111
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/44 (50%), Positives = 25/44 (56%)
Query: 337 DPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERP 380
D Q LP GWE++ D GRTYYV+HN RTT W RP
Sbjct: 60 DSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 37.4 bits (85), Expect = 0.065
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 7/51 (13%)
Query: 484 WE--DPRTQGLQNEE-----PLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
WE D Q++E PLP GWE + G Y+V+HN RTT + P
Sbjct: 53 WEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 473 bits (1216), Expect = e-133
Identities = 259/593 (43%), Positives = 352/593 (59%), Gaps = 56/593 (9%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESV------RNFEQWQSQRNQLQGA--- 433
LP GWE R R+ Y++H TRTT W+RPT + R + + + G
Sbjct: 159 LPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGA 218
Query: 434 ------------MQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKT 481
+ +QR+ S P LP G+E+R +VYF++ T
Sbjct: 219 TCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPP--DLPEGYEQRTTQQGQVYFLHTQTGV 276
Query: 482 TQWEDPRT----QGLQNEE--PLPEGWEIRYTREGVRYFVDHNTRTTTFKDPR------- 528
+ W DPR + EE PLP GWEIR T G YFVDHN RTT F DPR
Sbjct: 277 STWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHL 336
Query: 529 --NGKSSVTKGGPQIA---------------YERGFRWKLAHFRY-LCQSNALPSHVKIN 570
N ++ + Q Y+R KL R L Q H +I
Sbjct: 337 VLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIE 396
Query: 571 VSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCL 630
VSR+ +FE+S++Q+M ++P DL +RL + FRGEEGLDYGG+AREW +LLSHE+LNP Y L
Sbjct: 397 VSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGL 456
Query: 631 FEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKK 690
F+Y+ + Y LQINP S +NP+HLSYF F+GR + MA+FHG +ID GF+LPFYK++L K
Sbjct: 457 FQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKS 516
Query: 691 LTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTE 750
+T+ D+E +D + +NSL+WI +N+I L+ F V+ G++ H+LK G +I V E
Sbjct: 517 ITLDDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNE 575
Query: 751 ENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLA 810
ENK EY+ L WRF RG++ Q A GFNEV+P L+ FDEKELE+++CG+ ++D+
Sbjct: 576 ENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVN 635
Query: 811 DWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGP 870
DW+ NT +H T +S + WFW+ V+ D E R RLLQFVTG+ R+PL GF L G+ GP
Sbjct: 636 DWKVNTRLKHCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGP 695
Query: 871 QKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 922
+ F I ++ T LP++HTCFNR+D+PPY+SYE+L EKLL AIEET GF E
Sbjct: 696 RLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748
Score = 67.8 bits (164), Expect = 4e-11
Identities = 37/100 (37%), Positives = 51/100 (51%), Gaps = 16/100 (16%)
Query: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--------------PLPPGWERRVDDRRR 396
LP G+EQR G+ Y++ T +TW P+ PLPPGWE R R
Sbjct: 253 LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGR 312
Query: 397 VYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQ 436
VY+VDHN RTT + P + + N +++NQL+ QQ
Sbjct: 313 VYFVDHNNRTTQFTDPRLSA--NLHLVLNRQNQLKDQQQQ 350
Score = 38.5 bits (88), Expect = 0.029
Identities = 22/84 (26%), Positives = 45/84 (53%), Gaps = 3/84 (3%)
Query: 8 SDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKW 64
S+ +G ++L++TV AK KK++F + +VVVDG + T ++ +PKW
Sbjct: 2 SNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKW 61
Query: 65 DEQLTVNVTPQTTLEFQVWSHRTL 88
++ + + ++ VW+H+ +
Sbjct: 62 NQHYDLYIGKSDSVTISVWNHKKI 85
Score = 35.0 bits (79), Expect = 0.32
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGG 538
+ LP+GWE R T G +++H TRTT ++ P S + G
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPG 199
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 452 bits (1164), Expect = e-127
Identities = 239/513 (46%), Positives = 322/513 (62%), Gaps = 37/513 (7%)
Query: 446 SMLAAENDPYG----PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE----- 496
S+ +N P+G LP G+E+R +VYF++ T + W DPR N
Sbjct: 220 SLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDEL 279
Query: 497 -PLPEGWEIRYTREGVRYFVDHNTRTTTFKDPR-----NGKSSVTKGG------------ 538
PLP GWE+R T G YFVDHN RTT F DPR N + + +
Sbjct: 280 GPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLE 339
Query: 539 ----PQIAYERGFRWKLAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLR 593
P YER KL R+ L H +I VSR+ +FE+S++QIM ++P DL+
Sbjct: 340 DEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLK 399
Query: 594 RRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDH 653
+RL V FRGEEGLDYGG+AREW +LL HE+LNP Y LF+Y+ N Y LQINP S+INPDH
Sbjct: 400 KRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDH 459
Query: 654 LSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN 713
LSYF F+GR + +A+FHG +I+ GF++PFYK++L K + + DLES+D E + SL+WI +N
Sbjct: 460 LSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 519
Query: 714 NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQT 773
+I L+ F V+ G++ H+LK G N+ VTEENK EY+ L WRF RG++ Q
Sbjct: 520 DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQF 578
Query: 774 KAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQ 833
A GFNE++P L+ FD+KELE+++ G+ ++DL DW+ NT +H +S + WFWQ
Sbjct: 579 LALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQ 638
Query: 834 FVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSN---GPQKFCIEKVGKDT-WLPRSHT 889
V+ D E R RLLQFVTG+ R+PL GF L GS GP+ F I + +T LP++HT
Sbjct: 639 AVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHT 698
Query: 890 CFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 922
CFNR+D+PPY+SYE+L EKLL A+EET GF E
Sbjct: 699 CFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 731
Score = 68.6 bits (166), Expect = 3e-11
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 18/114 (15%)
Query: 325 EAAKSRQPD---GCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
+A + R PD P + G+ + E LP G+EQR G+ Y++ T +TW P+
Sbjct: 208 QAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR 266
Query: 382 --------------PLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFE 421
PLPPGWE R R+Y+VDHN RTT + P + + N +
Sbjct: 267 IPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 320
Score = 36.6 bits (83), Expect = 0.11
Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 21/165 (12%)
Query: 11 SNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKWDEQ 67
+ + +++++TV AK KK++F + ++VVDG + T ++ +PKW++
Sbjct: 6 TRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQH 65
Query: 68 LTVNVTPQTTLEFQVWSHRT---------LKADALLGKATIDLKQA-------LLIHNRK 111
+ V ++ VW+H+ L LL A LK ++
Sbjct: 66 YDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSD 125
Query: 112 LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSP 156
+ V+ Q+ +SL+ ++ I TG V GL +E E S P
Sbjct: 126 TDAVRGQIVVSLQTRDRIG-TGGSVVDCRGL-LENEGTVYEDSGP 168
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 447 bits (1150), Expect = e-125
Identities = 239/557 (42%), Positives = 331/557 (59%), Gaps = 52/557 (9%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYL 442
LP G+E+R + +VY++ T +TW P + S + G F +L
Sbjct: 236 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI---------PSPSGTIPGGDAAFLYEFL 286
Query: 443 YSA------SMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEE 496
+ + D GPLPPGWE R + R+YFV+HN +TTQ+ DPR + N +
Sbjct: 287 LQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQ 346
Query: 497 PLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGG------PQIAYERGFRWK 550
K+P ++G P YER K
Sbjct: 347 -------------------------CQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQK 381
Query: 551 LAHFRY-LCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYG 609
L R+ L H +I VSR+ +FE+S++QIM ++P DL++RL V FRGEEGLDYG
Sbjct: 382 LKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYG 441
Query: 610 GLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALF 669
G+AREW +LL HE+LNP Y LF+Y+ N Y LQINP S+INPDHLSYF F+GR + +A+F
Sbjct: 442 GVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVF 501
Query: 670 HGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDME 729
HG +I+ GF++PFYK++L K + + DLES+D E + SL+WI +N+I L+ F V+
Sbjct: 502 HGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV-LDHTFCVEHN 560
Query: 730 ILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWL 789
G++ H+LK G N+ VTEENK EY+ L WRF RG++ Q A GFNE++P L
Sbjct: 561 AFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLL 620
Query: 790 QYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQF 849
+ FD+KELE+++ G+ ++DL DW+ NT +H +S + WFWQ V+ D E R RLLQF
Sbjct: 621 KPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQF 680
Query: 850 VTGTCRLPLGGFAELMGSN---GPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQL 905
VTG+ R+PL GF L GS GP+ F I + +T LP++HTCFNR+D+PPY+SYE+L
Sbjct: 681 VTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKL 740
Query: 906 KEKLLFAIEETEGFGQE 922
EKLL A+EET GF E
Sbjct: 741 YEKLLTAVEETCGFAVE 757
Score = 58.5 bits (140), Expect = 3e-08
Identities = 38/140 (27%), Positives = 55/140 (39%), Gaps = 44/140 (31%)
Query: 325 EAAKSRQPD---GCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
+A + R PD P + G+ + E LP G+EQR G+ Y++ T +TW P+
Sbjct: 208 QAQRLRNPDVRGSLQTPQNRPHGHQSPE-LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPR 266
Query: 382 ----------------------------------------PLPPGWERRVDDRRRVYYVD 401
PLPPGWE R R+Y+VD
Sbjct: 267 IPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD 326
Query: 402 HNTRTTTWQRPTMESVRNFE 421
HN RTT + P + + N +
Sbjct: 327 HNNRTTQFTDPRLHHIMNHQ 346
Score = 48.9 bits (115), Expect = 2e-05
Identities = 82/390 (21%), Positives = 144/390 (36%), Gaps = 76/390 (19%)
Query: 11 SNNHSGRLQLQVTVSSAKLKRKKNWFGTAI-YTEVVVDG--EITKTAKSSSSSNPKWDEQ 67
+ + +++++TV AK KK++F + ++VVDG + T ++ +PKW++
Sbjct: 6 TRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQH 65
Query: 68 LTVNVTPQTTLEFQVWSHRT---------LKADALLGKATIDLKQA-------LLIHNRK 111
+ V ++ VW+H+ L LL A LK ++
Sbjct: 66 YDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSD 125
Query: 112 LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENG 171
+ V+ Q+ +SL+ ++ I G ++ +C + EN ++E+
Sbjct: 126 TDAVRGQIVVSLQTRDRIGTGG--------------SVVDCRG-----LLENEGTVYEDS 166
Query: 172 EPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPK 231
P R + E D+ T C +V +PS ++ A+ P +
Sbjct: 167 GP-GRPLSCFMEEPAPYTDS---TGAAAGGGNCRFV----ESPSQDQRLQAQRLRNPDVR 218
Query: 232 PLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSE 291
P + +G S P T V + L +T DP +
Sbjct: 219 GSLQTP-QNRPHGHQSPELP--EGYEQRTTVQGQVYFLHTQTGVSTWHDPRI------PS 269
Query: 292 NNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETL 351
+ IP A E +L+ TS R ++ + + P L
Sbjct: 270 PSGTIPGGDAAFLYE--FLLQGHTSEPRDLNSVNCDE-------LGP------------L 308
Query: 352 PSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
P GWE R GR Y+VDHN RTT + P+
Sbjct: 309 PPGWEVRSTVSGRIYFVDHNNRTTQFTDPR 338
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 378 bits (971), Expect = e-104
Identities = 233/603 (38%), Positives = 327/603 (54%), Gaps = 47/603 (7%)
Query: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ-PLPPG------WERRVDDRRRVYY---- 399
LP GWE + D G++++VDHN+R TT+ P+ PL G R+ R R Y
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1079
Query: 400 --VDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGP 457
V N + RP V Q Q L A +L ++ +
Sbjct: 1080 SEVSRNRGASLLARPGHSLVAAIRS-QHQHESLPLAYNDKIVAFLRQPNIFEMLQERQ-- 1136
Query: 458 LPPGWEKRVDSTDRVYFV----NHNTKTTQWEDPRT-------QGLQNEEPLPEGWEIRY 506
P + ++++++ NH + + + + + PL + Y
Sbjct: 1137 --PSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGY 1194
Query: 507 TREGVRYFVDHNTRTTTFKDPRN--GKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNAL- 563
+ + R + P+N G + P Y R F KL +F ++
Sbjct: 1195 S---------FSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFG 1244
Query: 564 --PSHVKINVSRQTLFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLS 620
P +K+ + R L E +F Q+MA +L+R +LYV F GEEGLDY G +RE+FFLLS
Sbjct: 1245 QGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLS 1304
Query: 621 HEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSL 680
E+ NP Y LFEY+ + Y +QI+P S +HL +F F GR + +AL H +D F+
Sbjct: 1305 QELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTR 1364
Query: 681 PFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLK 740
PFYK +L + DLE +D EF+ SL W++DNNI + L++ F+V+ E+ G+VT +LK
Sbjct: 1365 PFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELK 1423
Query: 741 LGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVM 800
GG+N VTE+NK EYI M +WR RGV +QT+A + GF EVV + + FD +ELE++
Sbjct: 1424 SGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELV 1483
Query: 801 LCGMQEVDLADWQRNTVYRHYTRNSKQII-WFWQFVKETDNEVRMRLLQFVTGTCRLPLG 859
+ G E+DL DW+ NT YR + +I WFW V+ +NE R+RLLQFVTGT +P
Sbjct: 1484 IAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYE 1543
Query: 860 GFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
GFA L GSNG ++FCIEK GK T LPR+HTCFNRLDLPPY SY L EKLL A+EET F
Sbjct: 1544 GFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
Query: 920 GQE 922
G E
Sbjct: 1604 GLE 1606
Score = 66.6 bits (161), Expect = 1e-10
Identities = 85/344 (24%), Positives = 131/344 (38%), Gaps = 43/344 (12%)
Query: 130 AQTGELTVVLDGLVIEQENITNCSS-----SPTIEIQENGDALHENGEPSARTTARLAVE 184
AQ G DG E+E+ SS S + + AL E+ E T A
Sbjct: 573 AQGGSAAEEEDGA--EEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHP 630
Query: 185 GTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKN------TPAPKPLASEPA 238
G +G H P+ + N +GD PS+ S+ + P+ S
Sbjct: 631 GHSG--GHFPS---LANGAAQ---DGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSC 682
Query: 239 DDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSS------EN 292
+ +S ++ + ++ +P N + + ++V+ + E S E
Sbjct: 683 YSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEE 742
Query: 293 NECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK-----SRQPDGCMDPVRQQSGNAN 347
N S ++S L+P+++N E A R P+G PV S
Sbjct: 743 NSAFESVPDSMQSPE---LDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRRE 799
Query: 348 TETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTT 407
E P + + +H+ T E PLPP WE R+D RV+YVDH RTT
Sbjct: 800 GEC-PILHNSQPVSQLPSLRPEHHHYPTIDE---PLPPNWEARIDSHGRVFYVDHVNRTT 855
Query: 408 TWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAE 451
TWQRPT + + + Q M+Q N+RY +A E
Sbjct: 856 TWQRPTAAATPDGMRRSGSIQQ----MEQLNRRYQNIQRTIATE 895
Score = 46.6 bits (109), Expect = 1e-04
Identities = 17/31 (54%), Positives = 23/31 (74%)
Query: 457 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDP 487
PLPP WE R+DS RV++V+H +TT W+ P
Sbjct: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 38.9 bits (89), Expect = 0.022
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
+EPLP WE R G ++VDH RTTT++ P
Sbjct: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
Score = 38.9 bits (89), Expect = 0.022
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 16/77 (20%)
Query: 418 RNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNH 477
RNFE++Q R+ L + F L LP GWE + D + +FV+H
Sbjct: 995 RNFERYQHNRD-LVNFINMFADTRL--------------ELPRGWEIKTDQQGKSFFVDH 1039
Query: 478 NTKTTQWEDPRTQGLQN 494
N++ T + DPR LQN
Sbjct: 1040 NSRATTFIDPRIP-LQN 1055
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 377 bits (968), Expect = e-104
Identities = 231/589 (39%), Positives = 324/589 (55%), Gaps = 52/589 (8%)
Query: 383 LPPGWERRVDDRRRVYYVDHNTRTTTW---------QRPTMESVRNFEQWQSQRNQLQGA 433
LP GWE + D + + ++VDHN+RTTT+ RPT V + QR+ G
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHR-QHLTRQRSHSAGE 1045
Query: 434 MQQ----------------FN--QRYLYSASMLAAENDPYGPL--PPGWEKRVDSTDRVY 473
+ + FN R Y + A ND P + +
Sbjct: 1046 VGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDL 1105
Query: 474 FVNHNTKTTQWEDPRTQGLQNEEPLPEGWEI-----RYTREGVRYFVDHNTRTTTF-KDP 527
NH+ + + + RT+G L ++ + E + Y H ++ + P
Sbjct: 1106 TRNHSLRE-KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSP 1164
Query: 528 RNGKSSVTKGGP---------QIAYERGFRWKLAHFRYLCQSNAL---PSHVKINVSRQT 575
R S + P Y+R F KL +F ++ P +K+ + R
Sbjct: 1165 RGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDH 1224
Query: 576 LFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYA 634
L ED+F QIM DL+R +LYV F GEEGLDY G +RE+FFL+S E+ NP Y LFEY+
Sbjct: 1225 LLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYS 1284
Query: 635 GKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIK 694
+ Y +QI+P S +H +F F GR + +AL H +D F+ PFYK +L +
Sbjct: 1285 ANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLS 1344
Query: 695 DLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKD 754
DLE +D EF+ SL W++DN+I + L++ F+V+ E+ G++T +LK GG+NI VTE+NK
Sbjct: 1345 DLEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKK 1403
Query: 755 EYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQR 814
EYI M +WR RGV +QT++ + GF EVV + + FD +ELE+++ G E+DL+DW+
Sbjct: 1404 EYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRN 1463
Query: 815 NTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKF 873
NT YR Y N I WFW V+ +NE R+RLLQFVTGT +P GFA L GSNGP++F
Sbjct: 1464 NTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRF 1523
Query: 874 CIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 922
C+EK GK T LPR+HTCFNRLDLPPY S+ L EKLL A+EET FG E
Sbjct: 1524 CVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
Score = 63.9 bits (154), Expect = 6e-10
Identities = 61/222 (27%), Positives = 84/222 (37%), Gaps = 52/222 (23%)
Query: 229 APKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILT 288
A +P +S PA+ G S + V P +E P S TV D +E+
Sbjct: 685 AAEPTSSGPAE----GSQESVCTAGSLPVVQVPSGEDEG---PGAESATVPDQ--EELGE 735
Query: 289 SSENNECIPSTSAELES---------EARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPV 339
+ + +A ES EA+ E T+ ++ A QP + V
Sbjct: 736 VWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSV 795
Query: 340 RQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYY 399
RQ QR D + LPP WE R+D R++Y
Sbjct: 796 RQDVSRY----------QRVD--------------------EALPPNWEARIDSHGRIFY 825
Query: 400 VDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRY 441
VDH RTTTWQRPT Q + N +Q M+Q N+RY
Sbjct: 826 VDHVNRTTTWQRPTAPPA---PQVLQRSNSIQ-QMEQLNRRY 863
Score = 47.8 bits (112), Expect = 5e-05
Identities = 32/111 (28%), Positives = 50/111 (45%), Gaps = 18/111 (16%)
Query: 458 LPPGWEKRVDSTDRVYFVNHNTKTTQWE----DPRTQGLQNEEPLPEGWEIRYTREGVRY 513
LPP WE R+DS R+++V+H +TT W+ P Q LQ + + ++ + +R
Sbjct: 809 LPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIR- 867
Query: 514 FVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALP 564
RT T + P +++ G E F A FR + N LP
Sbjct: 868 ------RTMTNERPEENTNAIDGAGE----EADFHQASADFR---RENILP 905
Score = 43.1 bits (100), Expect = 0.001
Identities = 16/31 (51%), Positives = 23/31 (74%)
Query: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
LP GWE + D G+ ++VDHN+RTTT+ P+
Sbjct: 987 LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPR 1017
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/79 (32%), Positives = 40/79 (50%), Gaps = 16/79 (20%)
Query: 419 NFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHN 478
+FE++Q R+ L G + F + L LP GWE + D + +FV+HN
Sbjct: 963 HFERYQHNRD-LVGFLNMFANKQL--------------ELPRGWEMKHDHQGKAFFVDHN 1007
Query: 479 TKTTQWEDPRTQGLQNEEP 497
++TT + DPR LQ+ P
Sbjct: 1008 SRTTTFIDPRLP-LQSSRP 1025
Score = 35.8 bits (81), Expect = 0.19
Identities = 15/33 (45%), Positives = 20/33 (60%)
Query: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
+E LP WE R G ++VDH RTTT++ P
Sbjct: 806 DEALPPNWEARIDSHGRIFYVDHVNRTTTWQRP 838
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 325 bits (833), Expect = 1e-88
Identities = 155/354 (43%), Positives = 234/354 (66%), Gaps = 2/354 (0%)
Query: 569 INVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMY 628
++V R +FEDS++++ P +++ RLY++F GEEG D GGL REW+ ++S E+ NPMY
Sbjct: 4019 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMY 4078
Query: 629 CLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLS 688
LF + + INP+S NP+HLSYF F+GR +A A++ + ++ F+ FYK +L
Sbjct: 4079 ALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILG 4138
Query: 689 KKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILV 748
K + D+ES D FY L+++ +N++ G ++ FS +++ G DLK G+NILV
Sbjct: 4139 KSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILV 4198
Query: 749 TEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVD 808
TEENK EY+ L+ + R + +++Q AFL+GF E++P + + F E+ELE+++ G+ +D
Sbjct: 4199 TEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTID 4258
Query: 809 LADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSN 868
+ D + NT Y Y NS QI WFW+ ++ D R + LQFVTGT ++PL GFA L G N
Sbjct: 4259 IDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMN 4318
Query: 869 GPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 920
G QKF I + + T LP +HTCFN+LDLP Y+S+E+L+ LL AI+E +EGFG
Sbjct: 4319 GIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFG 4372
Score = 30.8 bits (68), Expect = 6.1
Identities = 42/167 (25%), Positives = 63/167 (37%), Gaps = 31/167 (18%)
Query: 153 SSSPTI-----EIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYV 207
S +PTI E E+ DAL T +EG+ P T SC
Sbjct: 2826 SPAPTITSLSPERAEDSDAL---------TAVSSQLEGS-------PMDTSSLASCTLEE 2869
Query: 208 VNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEEN 267
GD + + S+ +TP P A +G S P +++S P S E+
Sbjct: 2870 AVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSS----PPASSES 2925
Query: 268 ALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPD 314
+ S ++ + + IL E +PSTS+E E I P+
Sbjct: 2926 S-STRDSAVAISGADSRGIL-----EEPLPSTSSEEEDPLAGISLPE 2966
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 280 bits (717), Expect = 3e-75
Identities = 150/345 (43%), Positives = 212/345 (61%), Gaps = 4/345 (1%)
Query: 571 VSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCL 630
V R ++F S + + L++ + V F GEEG+ G + REWF +LS+E++NP Y L
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG-VVREWFDILSNEIVNPDYAL 615
Query: 631 FEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKK 690
F + Q N S +NPDHL+YF F G+ + +AL H + ++ F+ FYK +L
Sbjct: 616 FTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP 674
Query: 691 LTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTE 750
+ +D+ SID E+ +L WI DN+I + GLE+ FSV+ ++ G + LK GG +ILVT+
Sbjct: 675 VNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQ 734
Query: 751 ENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLA 810
NK EY+ L+TE R +R +Q Q AFL GF+ +P +Q FDE ELE++L GM E+D++
Sbjct: 735 NNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVS 794
Query: 811 DWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNG 869
DW +NT Y Y R I WFW+ V++ E R+ LLQFVTG+ R+P GGFA +MG +G
Sbjct: 795 DWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSG 854
Query: 870 PQKFCIEKVG-KDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAI 913
Q F I V LP S TC N L LP Y S E LK++LL A+
Sbjct: 855 LQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 201 bits (512), Expect = 2e-51
Identities = 128/374 (34%), Positives = 204/374 (54%), Gaps = 23/374 (6%)
Query: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613
L Q L ++++ V R + +D+ + I P DL+++LYV F GE+G+D GG+++
Sbjct: 510 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 569
Query: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673
E+F L+ E+ NP +F Y ++ NP+S + F IG + +A+++
Sbjct: 570 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 625
Query: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731
+D F + Y++++ KK T +DL Y SL + + N+E+ + + ++
Sbjct: 626 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 685
Query: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVV---PLQW 788
G +DLK G I +T EN+ E++ L +++ ++ V++Q KAF GF+ V PL++
Sbjct: 686 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 745
Query: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLL 847
L F +E+E+++CG + +D + T Y YTR+S I FW+ V +E + L
Sbjct: 746 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 803
Query: 848 QFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLK 906
QF TGT R P+GG +L K I K G DT LP SHTCFN L LP Y S E+LK
Sbjct: 804 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 856
Query: 907 EKLLFAIEETEGFG 920
E+LL AI +GFG
Sbjct: 857 ERLLKAITYAKGFG 870
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 201 bits (512), Expect = 2e-51
Identities = 128/374 (34%), Positives = 204/374 (54%), Gaps = 23/374 (6%)
Query: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613
L Q L ++++ V R + +D+ + I P DL+++LYV F GE+G+D GG+++
Sbjct: 490 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 549
Query: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673
E+F L+ E+ NP +F Y ++ NP+S + F IG + +A+++
Sbjct: 550 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 605
Query: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731
+D F + Y++++ KK T +DL Y SL + + N+E+ + + ++
Sbjct: 606 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 665
Query: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVV---PLQW 788
G +DLK G I +T EN+ E++ L +++ ++ V++Q KAF GF+ V PL++
Sbjct: 666 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 725
Query: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLL 847
L F +E+E+++CG + +D + T Y YTR+S I FW+ V +E + L
Sbjct: 726 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 783
Query: 848 QFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLK 906
QF TGT R P+GG +L K I K G DT LP SHTCFN L LP Y S E+LK
Sbjct: 784 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 836
Query: 907 EKLLFAIEETEGFG 920
E+LL AI +GFG
Sbjct: 837 ERLLKAITYAKGFG 850
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 201 bits (512), Expect = 2e-51
Identities = 128/374 (34%), Positives = 204/374 (54%), Gaps = 23/374 (6%)
Query: 557 LCQSNALPSHVKINVSRQTLFEDSF---QQIMALKPYDLRRRLYVIFRGEEGLDYGGLAR 613
L Q L ++++ V R + +D+ + I P DL+++LYV F GE+G+D GG+++
Sbjct: 513 LVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSK 572
Query: 614 EWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKF 673
E+F L+ E+ NP +F Y ++ NP+S + F IG + +A+++
Sbjct: 573 EFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCI 628
Query: 674 IDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSL--IWIRDNNIEECGLEMYFSVDMEIL 731
+D F + Y++++ KK T +DL Y SL + + N+E+ + + ++
Sbjct: 629 LDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLF 688
Query: 732 GKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVV---PLQW 788
G +DLK G I +T EN+ E++ L +++ ++ V++Q KAF GF+ V PL++
Sbjct: 689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKY 748
Query: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVY-RHYTRNSKQIIWFWQFVKETDNEVRMRLL 847
L F +E+E+++CG + +D + T Y YTR+S I FW+ V +E + L
Sbjct: 749 L--FRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFL 806
Query: 848 QFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLK 906
QF TGT R P+GG +L K I K G DT LP SHTCFN L LP Y S E+LK
Sbjct: 807 QFTTGTDRAPVGGLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLK 859
Query: 907 EKLLFAIEETEGFG 920
E+LL AI +GFG
Sbjct: 860 ERLLKAITYAKGFG 873
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 199 bits (506), Expect = 1e-50
Identities = 129/375 (34%), Positives = 200/375 (53%), Gaps = 34/375 (9%)
Query: 567 VKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNP 626
+ + V R L DS ++ K DL+++L V F GE GLD GGL +EWF LL ++ +P
Sbjct: 417 LNMKVRRTHLVSDSLDELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHP 475
Query: 627 MYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRM 686
Y +F Y K+++C S+ D+ S F +G + +A+++ +D F YK++
Sbjct: 476 DYGMFTYH-KDSHCHWF---SSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKL 531
Query: 687 LSKKL--------------TIKDLESIDTEFYNSL--IWIRDNNIEECGLEMY--FSVDM 728
LS + T+ DL I E + L + + N+EE + Y F V
Sbjct: 532 LSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEE---DFYSTFQVFQ 588
Query: 729 EILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQW 788
E G + S++LK GG I VT +N+ EY+ L T++ ++ + +Q AF GF+ V
Sbjct: 589 EEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNA 648
Query: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 848
L +E+E+++CG ++D+ QR+T Y Y + I +FW V +++ +LL
Sbjct: 649 LMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLH 708
Query: 849 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYEQLKE 907
F TG+ R+P+GG A+L F I K T LP +HTCFN+L LPPYKS + LK+
Sbjct: 709 FTTGSDRVPVGGMADL-------NFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQ 761
Query: 908 KLLFAIEETEGFGQE 922
KL+ I +EGFG E
Sbjct: 762 KLIIGISNSEGFGLE 776
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 182 bits (461), Expect = 2e-45
Identities = 127/373 (34%), Positives = 189/373 (50%), Gaps = 28/373 (7%)
Query: 565 SHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVL 624
S V + VSR L E S + D + V+F+ EE LD+GG REWF L+ +
Sbjct: 460 SKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALF 519
Query: 625 NPMYCLFEYAGKNNYCLQINPASTINPDHL--SYFCFIGRFIAMALFHG-------KFID 675
+ LF NN L ++P P HL + F GR + L+ + +
Sbjct: 520 DTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVR 577
Query: 676 TGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLI-WIRDNNIEECGLEMYFSVDMEI---- 730
F+ F +++ ++ K E+ D EFY S + +I +N++ E +E+ F+ +
Sbjct: 578 ARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSE--MELVFAEEKYNKSGQ 635
Query: 731 LGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQ 790
L KV +L GG+ VT NK Y+ L+ ++R + V+E+ + FL G NE+VP L
Sbjct: 636 LDKVV--ELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLA 693
Query: 791 YFDEKELEVMLCGMQEVDLADWQRNTVY--RHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 848
FDE ELE+++CG ++ ++D++ + V + K + WFW V E RLLQ
Sbjct: 694 IFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQ 753
Query: 849 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 908
F TG+ +LP GGFA L S F I + LP +HTCFN+L LP Y SYE++
Sbjct: 754 FTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRM 808
Query: 909 LLFAIEE-TEGFG 920
L AI E EGFG
Sbjct: 809 LQLAISEGCEGFG 821
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 171 bits (432), Expect = 4e-42
Identities = 121/395 (30%), Positives = 194/395 (49%), Gaps = 38/395 (9%)
Query: 560 SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLARE 614
S+A P I + R + ED ++Q+ L + ++ + V F E G+D G+ +E
Sbjct: 674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
Query: 615 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674
+ + V +P LF+ + L +P S I+ ++L F F+G+ + A++ G +
Sbjct: 734 FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
Query: 675 DTGFSLPFYKRMLSKK-----LTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVD 727
D F+ F ++L ++ +L S+D+EFY +L I+ D +I + GL + S D
Sbjct: 793 DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL--SYD 850
Query: 728 MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQ 787
+++G++ H+L GG I VT ENK YI LM +R ++ QT A + GF ++ +
Sbjct: 851 EDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPE 910
Query: 788 WLQYFDEKELEVMLCG-MQEVDLADWQRNTV-YRHYTRNSKQIIWFWQFV-KETDNEVRM 844
W++ F EL+ ++ G E+DL D +++TV Y + + + IIW W + + + R
Sbjct: 911 WIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERA 970
Query: 845 RLLQFVTGTCRLPLGGFAEL--------------------MGSNGPQKFCIEKVGKDTWL 884
L+FVT R PL GFA L +GS F I K L
Sbjct: 971 MFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRL 1030
Query: 885 PRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
P S TCFN L LP Y L+EKL +AI GF
Sbjct: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 171 bits (432), Expect = 4e-42
Identities = 121/395 (30%), Positives = 194/395 (49%), Gaps = 38/395 (9%)
Query: 560 SNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLARE 614
S+A P I + R + ED ++Q+ L + ++ + V F E G+D G+ +E
Sbjct: 674 SSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKE 733
Query: 615 WFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFI 674
+ + V +P LF+ + L +P S I+ ++L F F+G+ + A++ G +
Sbjct: 734 FLEEIIKRVFDPALNLFKTTSGDER-LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVV 792
Query: 675 DTGFSLPFYKRMLSKK-----LTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVD 727
D F+ F ++L ++ +L S+D+EFY +L I+ D +I + GL + S D
Sbjct: 793 DVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTL--SYD 850
Query: 728 MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQ 787
+++G++ H+L GG I VT ENK YI LM +R ++ QT A + GF ++ +
Sbjct: 851 EDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPE 910
Query: 788 WLQYFDEKELEVMLCG-MQEVDLADWQRNTV-YRHYTRNSKQIIWFWQFV-KETDNEVRM 844
W++ F EL+ ++ G E+DL D +++TV Y + + + IIW W + + + R
Sbjct: 911 WIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERA 970
Query: 845 RLLQFVTGTCRLPLGGFAEL--------------------MGSNGPQKFCIEKVGKDTWL 884
L+FVT R PL GFA L +GS F I K L
Sbjct: 971 MFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRL 1030
Query: 885 PRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
P S TCFN L LP Y L+EKL +AI GF
Sbjct: 1031 PTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1065
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 170 bits (430), Expect = 6e-42
Identities = 118/367 (32%), Positives = 192/367 (52%), Gaps = 23/367 (6%)
Query: 567 VKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLAREWFFLLSH 621
+ + + R ++ED++ ++ DL++R+ V E G+D GG+ RE+ L
Sbjct: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
Query: 622 EVLNPMYCLFEYAGKNNYCLQINPAST--INPDHLSYFCFIGRFIAMALFHGKFIDTGFS 679
NP F+ N L NPA+ + ++ F+GR + AL+ ++ F+
Sbjct: 783 SGFNPNQGFFKTT--NEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
Query: 680 LPFYKRML--SKKLTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVDMEILGKVT 735
F ++L S + I L S+D E Y +L++++ ++++EE GL F+V LG+
Sbjct: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLN--FTVVNNDLGEAQ 898
Query: 736 SHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEK 795
+LK GG +I VT N+ YI L+ ++R +R +++ AF G VV L+WL+ FD++
Sbjct: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
Query: 796 ELEVMLCGMQ-EVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGT 853
E++V++ G Q + L D + T Y Y+ + I FW+ V+ +E + +LL+FVT
Sbjct: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
Query: 854 CRLPLGGFAELMGSNGPQKFCIEKVGKD-TWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 912
R PL GF EL + FCI G D LP + TC N L LP + L+ KLL+A
Sbjct: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
Query: 913 IEETEGF 919
IE GF
Sbjct: 1074 IECAAGF 1080
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,394,044
Number of Sequences: 37866
Number of extensions: 1783158
Number of successful extensions: 7780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 6190
Number of HSP's gapped (non-prelim): 1341
length of query: 922
length of database: 18,247,518
effective HSP length: 112
effective length of query: 810
effective length of database: 14,006,526
effective search space: 11345286060
effective search space used: 11345286060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.