Search of human proteins with 68800360

Search of human proteins with 68800360

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|68800360 dermatan sulfate proteoglycan 3 precursor [Homo
sapiens]
         (322 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|68800360 dermatan sulfate proteoglycan 3 precursor [Homo sapi...   654   0.0  
gi|7657419 opticin precursor [Homo sapiens]                           242   3e-64
gi|7661704 osteoglycin preproprotein [Homo sapiens]                   231   5e-61
gi|14916498 osteoglycin preproprotein [Homo sapiens]                  231   5e-61
gi|4505047 lumican precursor [Homo sapiens]                            92   8e-19
gi|19743846 decorin isoform a preproprotein [Homo sapiens]             90   2e-18
gi|4503271 decorin isoform a preproprotein [Homo sapiens]              90   2e-18
gi|4826876 osteomodulin [Homo sapiens]                                 89   5e-18
gi|188528675 slit homolog 1 [Homo sapiens]                             89   7e-18
gi|11321571 slit homolog 3 [Homo sapiens]                              85   8e-17
gi|5901992 keratocan [Homo sapiens]                                    83   4e-16
gi|41350214 asporin [Homo sapiens]                                     82   5e-16
gi|41349454 proline arginine-rich end leucine-rich repeat protei...    82   6e-16
gi|4506041 proline arginine-rich end leucine-rich repeat protein...    82   6e-16
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor...    81   1e-15
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor...    81   1e-15
gi|4759146 slit homolog 2 [Homo sapiens]                               77   2e-14
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    75   1e-13
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa...    74   1e-13
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]                   74   2e-13
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]                   74   2e-13
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ...    74   2e-13
gi|71040111 fibromodulin precursor [Homo sapiens]                      71   1e-12
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]             71   1e-12
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]     71   1e-12
gi|45505137 podocan [Homo sapiens]                                     71   1e-12
gi|4502403 biglycan preproprotein [Homo sapiens]                       70   3e-12
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   70   3e-12
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...    70   3e-12
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo...    69   7e-12

>gi|68800360 dermatan sulfate proteoglycan 3 precursor [Homo
           sapiens]
          Length = 322

 Score =  654 bits (1687), Expect = 0.0
 Identities = 322/322 (100%), Positives = 322/322 (100%)

Query: 1   MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIAT 60
           MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIAT
Sbjct: 1   MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIAT 60

Query: 61  VMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL 120
           VMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL
Sbjct: 61  VMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL 120

Query: 121 CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS 180
           CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS
Sbjct: 121 CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS 180

Query: 181 EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH 240
           EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH
Sbjct: 181 EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH 240

Query: 241 HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP 300
           HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP
Sbjct: 241 HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP 300

Query: 301 INLSKTPQAYMCLPRLPVGSLV 322
           INLSKTPQAYMCLPRLPVGSLV
Sbjct: 301 INLSKTPQAYMCLPRLPVGSLV 322


>gi|7657419 opticin precursor [Homo sapiens]
          Length = 332

 Score =  242 bits (618), Expect = 3e-64
 Identities = 117/214 (54%), Positives = 151/214 (70%)

Query: 106 VLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFAS 165
           +L    N   PTCL+C C+ ++VYCDD +L+ IPPLP+ TAY Y+RFNRI +I   DF  
Sbjct: 116 LLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKG 175

Query: 166 LSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGR 225
           L+ LKRIDL++NLIS ID DAFR L  L++L+L +N++  LP LP+ + F+D+  NRL  
Sbjct: 176 LTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQS 235

Query: 226 KGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLT 285
            GI+  AF+ M  L  LYL+DN LD IP PLP +LR++HLQNN I  M  D FC+ +   
Sbjct: 236 SGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHK 295

Query: 286 YIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVG 319
           + R+ LEDIRLDGNPINLS  P AY CLPRLP+G
Sbjct: 296 HTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIG 329


>gi|7661704 osteoglycin preproprotein [Homo sapiens]
          Length = 298

 Score =  231 bits (590), Expect = 5e-61
 Identities = 127/325 (39%), Positives = 194/325 (59%), Gaps = 34/325 (10%)

Query: 1   MKTLAGLVLGLVIFDAAVTAPTLES-----INYDSETYDATLEDLDNLYNYENIPVDKVE 55
           MKTL   +L L++      AP  +       +Y ++ ++ ++   D    YE+  +D   
Sbjct: 1   MKTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFSQD----YEDKYLDGKN 56

Query: 56  IEIATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDF 115
           I+         +E +  P   EK+ + +++E  TP       P + E         N++ 
Sbjct: 57  IK--------EKETVIIPN--EKSLQLQKDEAITPL------PPKKE---------NDEM 91

Query: 116 PTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLT 175
           PTCLLC C+S +VYC++ ++DA+PPLPK +AY Y+RFN+IKK+   DFA + +L+R+D T
Sbjct: 92  PTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFT 151

Query: 176 SNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKD 235
            NLI +I++  F KL  L EL L +N++ +LP LP  LT  +   N++  +GIK  AFK 
Sbjct: 152 GNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKK 211

Query: 236 MYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIR 295
           + +L  LYL  N L+ +PL LPE+LR +HLQ NNI  + +DTFC   + +YIR  +E+IR
Sbjct: 212 LNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIR 271

Query: 296 LDGNPINLSKTPQAYMCLPRLPVGS 320
           L+GNPI L K P +++CL RLP+GS
Sbjct: 272 LEGNPIVLGKHPNSFICLKRLPIGS 296


>gi|14916498 osteoglycin preproprotein [Homo sapiens]
          Length = 298

 Score =  231 bits (590), Expect = 5e-61
 Identities = 127/325 (39%), Positives = 194/325 (59%), Gaps = 34/325 (10%)

Query: 1   MKTLAGLVLGLVIFDAAVTAPTLES-----INYDSETYDATLEDLDNLYNYENIPVDKVE 55
           MKTL   +L L++      AP  +       +Y ++ ++ ++   D    YE+  +D   
Sbjct: 1   MKTLQSTLLLLLLVPLIKPAPPTQQDSRIIYDYGTDNFEESIFSQD----YEDKYLDGKN 56

Query: 56  IEIATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDF 115
           I+         +E +  P   EK+ + +++E  TP       P + E         N++ 
Sbjct: 57  IK--------EKETVIIPN--EKSLQLQKDEAITPL------PPKKE---------NDEM 91

Query: 116 PTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLT 175
           PTCLLC C+S +VYC++ ++DA+PPLPK +AY Y+RFN+IKK+   DFA + +L+R+D T
Sbjct: 92  PTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADIPNLRRLDFT 151

Query: 176 SNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKD 235
            NLI +I++  F KL  L EL L +N++ +LP LP  LT  +   N++  +GIK  AFK 
Sbjct: 152 GNLIEDIEDGTFSKLSLLEELSLAENQLLKLPVLPPKLTLFNAKYNKIKSRGIKANAFKK 211

Query: 236 MYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIR 295
           + +L  LYL  N L+ +PL LPE+LR +HLQ NNI  + +DTFC   + +YIR  +E+IR
Sbjct: 212 LNNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIR 271

Query: 296 LDGNPINLSKTPQAYMCLPRLPVGS 320
           L+GNPI L K P +++CL RLP+GS
Sbjct: 272 LEGNPIVLGKHPNSFICLKRLPIGS 296


>gi|4505047 lumican precursor [Homo sapiens]
          Length = 338

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 71/244 (29%), Positives = 115/244 (47%), Gaps = 32/244 (13%)

Query: 92  LIDGSSPQEPEFT---GVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYF 148
           LI G+S Q  ++     + G  +    P C       + +YCD+ +L ++P +P    Y 
Sbjct: 12  LIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYL 71

Query: 149 YSRFNRIKKINKNDFASLSDLKRIDLTSNLI--SEIDEDAFRKLPQLRELVLRDNKI--- 203
           Y R N+I  I++  F +++DL+ + L  NL+  S+I    F KL QL++L +  N +   
Sbjct: 72  YLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTES 131

Query: 204 -----RQLPELPTT---------------LTFIDISNNRLGRKGIKQEAFKDMYDLHHLY 243
                + L +L  T               LTFI + +NRL    +   AFK +  L +L 
Sbjct: 132 VGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAV-SAAFKGLKSLEYLD 190

Query: 244 LTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIR---KALEDIRLDGNP 300
           L+ N +  +P  LP +L  L+L NN I  + ++ F     L Y+R     L D  + GN 
Sbjct: 191 LSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNS 250

Query: 301 INLS 304
            N+S
Sbjct: 251 FNVS 254


>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 73/242 (30%), Positives = 109/242 (45%), Gaps = 36/242 (14%)

Query: 100 EPEFTGVLGPHTNEDF-------PTC-LLCTCISTTVYCDDHELDAIPP-LPKNTAYFYS 150
           E E +G+ GP   +D        P C   C C    V C D  LD +P  LP +T     
Sbjct: 30  EDEASGI-GPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDL 88

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPE-L 209
           + N+I +I   DF +L +L  + L +N IS++   AF  L +L  L L  N++++LPE +
Sbjct: 89  QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148

Query: 210 PTTL----------------TF--------IDISNNRLGRKGIKQEAFKDMYDLHHLYLT 245
           P TL                TF        I++  N L   GI+  AF+ M  L ++ + 
Sbjct: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208

Query: 246 DNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSK 305
           D N+  IP  LP +L  LHL  N I  +   +   + NL  +  +   I    N  +L+ 
Sbjct: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG-SLAN 267

Query: 306 TP 307
           TP
Sbjct: 268 TP 269



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 38/219 (17%)

Query: 128 VYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI--SEIDE 184
           +Y   ++L  +P  +PK      +  N I K+ K  F  L+ +  I+L +N +  S I+ 
Sbjct: 134 LYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIEN 193

Query: 185 DAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNRLGR------KGIKQEA----- 232
            AF+ + +L  + + D  I  +P+ LP +LT + +  N++ R      KG+   A     
Sbjct: 194 GAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253

Query: 233 -----------FKDMYDLHHLYLTDNNLDHIPLPLPEN--LRALHLQNNNILEMHEDTFC 279
                        +   L  L+L +N L  +P  L E+  ++ ++L NNNI  +    FC
Sbjct: 254 FNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFC 313

Query: 280 ----NVKNLTYIRKALEDIRLDGNPINLSK-TPQAYMCL 313
               N K  +Y       + L  NP+   +  P  + C+
Sbjct: 314 PPGHNTKKASY-----SGVSLFSNPVQYWEIQPSTFRCV 347


>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
          Length = 359

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 73/242 (30%), Positives = 109/242 (45%), Gaps = 36/242 (14%)

Query: 100 EPEFTGVLGPHTNEDF-------PTC-LLCTCISTTVYCDDHELDAIPP-LPKNTAYFYS 150
           E E +G+ GP   +D        P C   C C    V C D  LD +P  LP +T     
Sbjct: 30  EDEASGI-GPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDL 88

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPE-L 209
           + N+I +I   DF +L +L  + L +N IS++   AF  L +L  L L  N++++LPE +
Sbjct: 89  QNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM 148

Query: 210 PTTL----------------TF--------IDISNNRLGRKGIKQEAFKDMYDLHHLYLT 245
           P TL                TF        I++  N L   GI+  AF+ M  L ++ + 
Sbjct: 149 PKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIA 208

Query: 246 DNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSK 305
           D N+  IP  LP +L  LHL  N I  +   +   + NL  +  +   I    N  +L+ 
Sbjct: 209 DTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNG-SLAN 267

Query: 306 TP 307
           TP
Sbjct: 268 TP 269



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 38/219 (17%)

Query: 128 VYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI--SEIDE 184
           +Y   ++L  +P  +PK      +  N I K+ K  F  L+ +  I+L +N +  S I+ 
Sbjct: 134 LYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIEN 193

Query: 185 DAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNRLGR------KGIKQEA----- 232
            AF+ + +L  + + D  I  +P+ LP +LT + +  N++ R      KG+   A     
Sbjct: 194 GAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253

Query: 233 -----------FKDMYDLHHLYLTDNNLDHIPLPLPEN--LRALHLQNNNILEMHEDTFC 279
                        +   L  L+L +N L  +P  L E+  ++ ++L NNNI  +    FC
Sbjct: 254 FNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFC 313

Query: 280 ----NVKNLTYIRKALEDIRLDGNPINLSK-TPQAYMCL 313
               N K  +Y       + L  NP+   +  P  + C+
Sbjct: 314 PPGHNTKKASY-----SGVSLFSNPVQYWEIQPSTFRCV 347


>gi|4826876 osteomodulin [Homo sapiens]
          Length = 421

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 64/217 (29%), Positives = 97/217 (44%), Gaps = 29/217 (13%)

Query: 118 CLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSN 177
           C   T   +++YCD+ +L  IP +P +    Y +FN I+ +  N F + + LK I+L+ N
Sbjct: 66  CFCPTNFPSSMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHN 125

Query: 178 LI--SEIDEDAFRKLPQLRELVLRDNKIRQLP-ELP------------------------ 210
            I   +ID   F KLP L +L L  N + + P  LP                        
Sbjct: 126 KIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGL 185

Query: 211 TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNI 270
             LT +D+  N L    +K + F  M  L  L L  N L+ +P  LP +L  L L+NN+I
Sbjct: 186 VNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSI 245

Query: 271 LEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTP 307
             + E  F  +  L  +R  +   +L   P N+   P
Sbjct: 246 SSIPEKYFDKLPKLHTLR--MSHNKLQDIPYNIFNLP 280



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 58/216 (26%), Positives = 100/216 (46%), Gaps = 31/216 (14%)

Query: 128 VYCDDHELDAIP-PLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--IDE 184
           ++ + + L+  P PLPK+       +N I K+  N    L +L  +DL  N + +  + +
Sbjct: 146 LHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKD 205

Query: 185 DAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLY 243
             F K+ +L +L L  N++  +P  LP++L ++ + NN +    I ++ F  +  LH L 
Sbjct: 206 KIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSIS--SIPEKYFDKLPKLHTLR 263

Query: 244 LTDNNLDHIP-----LP-----------------LPENLRALHLQNNNILEMHEDTFC-N 280
           ++ N L  IP     LP                 +P NL  L+LQNN I +M+    C +
Sbjct: 264 MSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPS 323

Query: 281 VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRL 316
           +  L Y    L  IR+D N +    +   + C P +
Sbjct: 324 IDPLHY--HHLTYIRVDQNKLKEPISSYIFFCFPHI 357


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 62/177 (35%), Positives = 88/177 (49%), Gaps = 10/177 (5%)

Query: 120 LCTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNL 178
           LCTC  TTV C    L AIP  +P+NT       N I +I+KNDFA L  L+ + L  N 
Sbjct: 37  LCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQ 96

Query: 179 ISEIDEDAFRKLPQLRELVLRDNKIRQLPEL----PTTLTFIDISNNRLGRKGIKQEAFK 234
           I  ++  AF  + +L  L L  N++  LPEL       L+ +D+S N +  + I ++AF+
Sbjct: 97  IGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAI--QAIPRKAFR 154

Query: 235 DMYDLHHLYLTDNNLDHIPLPLPENLRALH---LQNNNILEMHEDTFCNVKNLTYIR 288
              DL +L L  N +  I       LR L    L NNNI  +   +F ++  L   R
Sbjct: 155 GATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFR 211



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 64/183 (34%), Positives = 87/183 (47%), Gaps = 23/183 (12%)

Query: 116 PTCLL--------CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASL 166
           PTC L        CTC +  V C    L AIP  LP+         N IK I    F+  
Sbjct: 273 PTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPY 332

Query: 167 SDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNR 222
             L+RIDL++N I+EI  DAF+ L  L  LVL  NKI  LP        TL  + ++ N+
Sbjct: 333 RKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANK 392

Query: 223 LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRA---LHLQNNNILEMHEDTFC 279
           +    I+ +AF+D+ +L  L L DN +  +      +LRA   LHL  N  +       C
Sbjct: 393 I--NCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFI-----CDC 445

Query: 280 NVK 282
           N+K
Sbjct: 446 NLK 448



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 8/134 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C+ T V C +  L A+P  +PKN    Y   N+   +     ++   L+ +DL++N I
Sbjct: 738 CACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNNKI 796

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S +   +F  + QL  L+L  N ++ +P L      +L  + +  N +    +++  F D
Sbjct: 797 SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST--LQEGIFAD 854

Query: 236 MYDLHHLYLTDNNL 249
           +  L HL +  N L
Sbjct: 855 VTSLSHLAIGANPL 868



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 47/171 (27%), Positives = 77/171 (45%), Gaps = 16/171 (9%)

Query: 107 LGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKND-FA 164
           L    N D      C C +  V C   +L  IP  +P++TA      N I  +     F 
Sbjct: 503 LNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFK 562

Query: 165 SLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI--------RQLPELPTTLTFI 216
            L+ LK+I+L++N +SEI++ AF     + EL L  N++        R L  L T +   
Sbjct: 563 KLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLM--- 619

Query: 217 DISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQN 267
            + NNR+    I  ++F  + ++  L L DN +  +     + L++L   N
Sbjct: 620 -LRNNRI--SCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLN 667



 Score = 30.4 bits (67), Expect = 2.2
 Identities = 16/51 (31%), Positives = 27/51 (52%)

Query: 153 NRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           N+I  I +  F +L  L+ + L +N I+ I   +F  +P+LR   L  N +
Sbjct: 167 NQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 85.1 bits (209), Expect = 8e-17
 Identities = 59/176 (33%), Positives = 94/176 (53%), Gaps = 10/176 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           CTC + +V C    L A+P  +P+N        N I +I K DFA L +L+ + L  N +
Sbjct: 38  CTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV 97

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPEL----PTTLTFIDISNNRLGRKGIKQEAFKD 235
           S I+  AF+ L QL  L L  NK++ LPEL       LT +D+S N++  +GI ++AF+ 
Sbjct: 98  SVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQI--QGIPRKAFRG 155

Query: 236 MYDLHHLYLTDNNLDHI---PLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIR 288
           + D+ +L L +N++  I         +L  L L NNNI  +   +F ++  +  +R
Sbjct: 156 ITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLR 211



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 51/156 (32%), Positives = 76/156 (48%), Gaps = 10/156 (6%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           CTC +  V C    L  IP  LP+         N IK I    F     LKRID++ N I
Sbjct: 284 CTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQI 343

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLP----ELPTTLTFIDISNNRLGRKGIKQEAFKD 235
           S+I  DAF+ L  L  LVL  NKI ++     +   +L  + ++ N++    ++   F+D
Sbjct: 344 SDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKI--NCLRVNTFQD 401

Query: 236 MYDLHHLYLTDNNLDHIPLPL---PENLRALHLQNN 268
           + +L+ L L DN L  I   L    ++++ LHL  N
Sbjct: 402 LQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQN 437



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 38/134 (28%), Positives = 65/134 (48%), Gaps = 8/134 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           CTC+ T V C +  L A+P  +PK+    Y   N +  + + + ++L  L  IDL++N I
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSI 787

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S +    F  +  L  L+L  N++R +P        +L  + +  N +    + + +F D
Sbjct: 788 SMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI--SSVPEGSFND 845

Query: 236 MYDLHHLYLTDNNL 249
           +  L HL L  N L
Sbjct: 846 LTSLSHLALGTNPL 859



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 1/69 (1%)

Query: 153 NRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL-PELPT 211
           N+++ ++   F  LS LK + L SNLI  +  D F  L  +R L L DN+I  + P   T
Sbjct: 591 NQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFT 650

Query: 212 TLTFIDISN 220
           TL  +   N
Sbjct: 651 TLVSLSTIN 659



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 59/207 (28%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C  T V C + +L  IP  LP+                      ++DL+   L  N +
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEY---------------------VTDLR---LNDNEV 544

Query: 180 SEIDEDA-FRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYD 238
           S ++    F+KLP LR++ L +NKI++                      +++ AF     
Sbjct: 545 SVLEATGIFKKLPNLRKINLSNNKIKE----------------------VREGAFDGAAS 582

Query: 239 LHHLYLTDNNLDHIPLPL---PENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIR 295
           +  L LT N L+ +   +      L+ L L++N I  +  DTF  + ++  +  +L D R
Sbjct: 583 VQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLL--SLYDNR 640

Query: 296 LDGNPINLSKTPQAYMCLPRLPVGSLV 322
           +       + TP A+  L  L   +L+
Sbjct: 641 I------TTITPGAFTTLVSLSTINLL 661



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 2/66 (3%)

Query: 222 RLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLP--ENLRALHLQNNNILEMHEDTFC 279
           R   KG++        D+  LYL  N+L  +P  L    +L  + L NN+I  +   TF 
Sbjct: 737 RCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFS 796

Query: 280 NVKNLT 285
           N+ +L+
Sbjct: 797 NMSHLS 802


>gi|5901992 keratocan [Homo sapiens]
          Length = 352

 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 60/220 (27%), Positives = 102/220 (46%), Gaps = 30/220 (13%)

Query: 111 TNEDFPTCLLCTC---ISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLS 167
           T  DF   + C C     T +YC++  L  IP +P    Y Y + N I+ I +  F + +
Sbjct: 36  TIHDFECPMECFCPPSFPTALYCENRGLKEIPAIPSRIWYLYLQNNLIETIPEKPFENAT 95

Query: 168 DLKRIDLTSNLISE--IDEDAFRKLPQLRELVLRDNKIRQLPE-LPTTL----------- 213
            L+ I+L  N I+   I++ A  +L +L  L L DN++ ++P  LP +L           
Sbjct: 96  QLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVS 155

Query: 214 -------------TFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENL 260
                        T +D+ NN+L     +++ FK + +L  L +  N L ++P  LP N 
Sbjct: 156 RIPQGTFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANT 215

Query: 261 RALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP 300
             L L NN+I  + E+ F  +  + ++R     +  +G P
Sbjct: 216 MQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLP 255


>gi|41350214 asporin [Homo sapiens]
          Length = 380

 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 61/198 (30%), Positives = 94/198 (47%), Gaps = 30/198 (15%)

Query: 115 FPTCLL-CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRI 172
           FP C   C C S  V+C D  L ++P  +P +T     + N+IK+I +NDF  L+ L  +
Sbjct: 72  FPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGL 131

Query: 173 DLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP-ELPTTLTFIDISNNRLGRKGIKQE 231
            L +N +++I   AF    +LR L L  N++ ++P  LP +L  + I  N++  K I+++
Sbjct: 132 ILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKV--KKIQKD 189

Query: 232 AFKDMYDLHHLYLTDNNLDH-------------------------IPLPLPENLRALHLQ 266
            FK M  LH L ++ N LD+                         +P  LP  L  LHL 
Sbjct: 190 TFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLD 249

Query: 267 NNNILEMHEDTFCNVKNL 284
            N I  +  + F   K L
Sbjct: 250 YNKISTVELEDFKRYKEL 267



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 28/99 (28%), Positives = 56/99 (56%), Gaps = 4/99 (4%)

Query: 134 ELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQ 192
           +L ++P  LP      +  +N+I  +   DF    +L+R+ L +N I++I+  +   +P+
Sbjct: 231 KLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPR 290

Query: 193 LRELVLRDNKIRQLPE-LPTT--LTFIDISNNRLGRKGI 228
           +RE+ L +NK++++P  LP    L  I + +N + R G+
Sbjct: 291 VREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGV 329


>gi|41349454 proline arginine-rich end leucine-rich repeat protein
           precursor [Homo sapiens]
          Length = 382

 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 70/266 (26%), Positives = 106/266 (39%), Gaps = 33/266 (12%)

Query: 72  PPPQPEKAQEEEEEEESTPRLIDGSSPQEP-EFTGVLGPHTNEDFPTCLL-CTC---IST 126
           P P     +        TP       P EP +    L P     FP C   C C     +
Sbjct: 26  PRPGTGPGRRPRPRPRPTPSFPQPDEPAEPTDLPPPLPPGPPSIFPDCPRECYCPPDFPS 85

Query: 127 TVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDA 186
            +YCD   L  +P +P    Y Y + N I ++    F + + L+ I+L +N I +ID+  
Sbjct: 86  ALYCDSRNLRKVPVIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRV 145

Query: 187 FRKLPQLRELVLRDNKIRQLPE-LP------------------------TTLTFIDISNN 221
             KLP L  L +  N++ ++P  LP                          L  +D+ +N
Sbjct: 146 LEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHN 205

Query: 222 RLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNV 281
           RL     K + F  + +L  L L  N L  +P  +P  +  L+L +N I  +    F + 
Sbjct: 206 RLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSF 265

Query: 282 KNLTYIR---KALEDIRLDGNPINLS 304
            NL +IR     L D  L  N  N+S
Sbjct: 266 PNLAFIRLNYNKLTDRGLPKNSFNIS 291



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 139 PPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--IDEDAFRKLPQLREL 196
           P +P      Y   N+I+ I    F S  +L  I L  N +++  + +++F  +  L  L
Sbjct: 238 PRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFN-ISNLLVL 296

Query: 197 VLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPL 256
            L  N+I  +P +   L  + ++NN + +    Q    D+   H      ++L+++P   
Sbjct: 297 HLSHNRISSVPAINNRLEHLYLNNNSIEKINGTQICPNDLVAFHDF---SSDLENVP--- 350

Query: 257 PENLRALHLQNN 268
             +LR L L  N
Sbjct: 351 --HLRYLRLDGN 360


>gi|4506041 proline arginine-rich end leucine-rich repeat protein
           precursor [Homo sapiens]
          Length = 382

 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 70/266 (26%), Positives = 106/266 (39%), Gaps = 33/266 (12%)

Query: 72  PPPQPEKAQEEEEEEESTPRLIDGSSPQEP-EFTGVLGPHTNEDFPTCLL-CTC---IST 126
           P P     +        TP       P EP +    L P     FP C   C C     +
Sbjct: 26  PRPGTGPGRRPRPRPRPTPSFPQPDEPAEPTDLPPPLPPGPPSIFPDCPRECYCPPDFPS 85

Query: 127 TVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDA 186
            +YCD   L  +P +P    Y Y + N I ++    F + + L+ I+L +N I +ID+  
Sbjct: 86  ALYCDSRNLRKVPVIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRV 145

Query: 187 FRKLPQLRELVLRDNKIRQLPE-LP------------------------TTLTFIDISNN 221
             KLP L  L +  N++ ++P  LP                          L  +D+ +N
Sbjct: 146 LEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHN 205

Query: 222 RLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNV 281
           RL     K + F  + +L  L L  N L  +P  +P  +  L+L +N I  +    F + 
Sbjct: 206 RLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSF 265

Query: 282 KNLTYIR---KALEDIRLDGNPINLS 304
            NL +IR     L D  L  N  N+S
Sbjct: 266 PNLAFIRLNYNKLTDRGLPKNSFNIS 291



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 139 PPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--IDEDAFRKLPQLREL 196
           P +P      Y   N+I+ I    F S  +L  I L  N +++  + +++F  +  L  L
Sbjct: 238 PRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFN-ISNLLVL 296

Query: 197 VLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPL 256
            L  N+I  +P +   L  + ++NN + +    Q    D+   H      ++L+++P   
Sbjct: 297 HLSHNRISSVPAINNRLEHLYLNNNSIEKINGTQICPNDLVAFHDF---SSDLENVP--- 350

Query: 257 PENLRALHLQNN 268
             +LR L L  N
Sbjct: 351 --HLRYLRLDGN 360


>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
           [Homo sapiens]
          Length = 518

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 69/245 (28%), Positives = 107/245 (43%), Gaps = 52/245 (21%)

Query: 121 CTCISTTVYCDDHELDAIPPLPKNTAYFYS-RFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C    VYC+ H    IP      +   S RFN I+K+  N FA L+ L  + L  N I
Sbjct: 38  CRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYI 97

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S +DEDAF+ + +L+EL+L  NKI  L          L  +D+S N+L  + ++ E FK 
Sbjct: 98  SSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL--QTLQSEQFKG 155

Query: 236 MYDLHHLYLTDNNLDHIPLPLPEN---------------------------LRALHLQNN 268
           +  L  L+L  N+L  +P+ + ++                           L+ LHL++N
Sbjct: 156 LRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN 215

Query: 269 NILEMHEDTFCNVKN-----------------LTYIRKALEDIRLDGNPINLSKTPQAYM 311
              +++   F  + N                 LT+   +L ++ L GN I     P  + 
Sbjct: 216 QFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ-GIEPGTFK 274

Query: 312 CLPRL 316
           CLP L
Sbjct: 275 CLPNL 279



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 21/65 (32%), Positives = 36/65 (55%)

Query: 144 NTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           N    Y ++NRI+ I++    + S L  +DL+ N I  I+   F+ LP L++L L  NK+
Sbjct: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289

Query: 204 RQLPE 208
             + +
Sbjct: 290 TNISQ 294



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 11/135 (8%)

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL---- 206
           R N +K +    F    +L  +DL  N +  +  +AF  L +L+EL L  N+  ++    
Sbjct: 165 RSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAH 224

Query: 207 -PELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHI---PLPLPENLRA 262
            P L   L  I +  NR+  + I Q        LH+L L+ N++  I         NL+ 
Sbjct: 225 FPRL-FNLRSIYLQWNRI--RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 281

Query: 263 LHLQNNNILEMHEDT 277
           L+L +N +  + ++T
Sbjct: 282 LNLDSNKLTNISQET 296


>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
           [Homo sapiens]
          Length = 590

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 69/245 (28%), Positives = 107/245 (43%), Gaps = 52/245 (21%)

Query: 121 CTCISTTVYCDDHELDAIPPLPKNTAYFYS-RFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C    VYC+ H    IP      +   S RFN I+K+  N FA L+ L  + L  N I
Sbjct: 38  CRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYI 97

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S +DEDAF+ + +L+EL+L  NKI  L          L  +D+S N+L  + ++ E FK 
Sbjct: 98  SSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL--QTLQSEQFKG 155

Query: 236 MYDLHHLYLTDNNLDHIPLPLPEN---------------------------LRALHLQNN 268
           +  L  L+L  N+L  +P+ + ++                           L+ LHL++N
Sbjct: 156 LRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN 215

Query: 269 NILEMHEDTFCNVKN-----------------LTYIRKALEDIRLDGNPINLSKTPQAYM 311
              +++   F  + N                 LT+   +L ++ L GN I     P  + 
Sbjct: 216 QFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ-GIEPGTFK 274

Query: 312 CLPRL 316
           CLP L
Sbjct: 275 CLPNL 279



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 21/65 (32%), Positives = 36/65 (55%)

Query: 144 NTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           N    Y ++NRI+ I++    + S L  +DL+ N I  I+   F+ LP L++L L  NK+
Sbjct: 230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289

Query: 204 RQLPE 208
             + +
Sbjct: 290 TNISQ 294



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 36/135 (26%), Positives = 62/135 (45%), Gaps = 11/135 (8%)

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL---- 206
           R N +K +    F    +L  +DL  N +  +  +AF  L +L+EL L  N+  ++    
Sbjct: 165 RSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAH 224

Query: 207 -PELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHI---PLPLPENLRA 262
            P L   L  I +  NR+  + I Q        LH+L L+ N++  I         NL+ 
Sbjct: 225 FPRL-FNLRSIYLQWNRI--RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQK 281

Query: 263 LHLQNNNILEMHEDT 277
           L+L +N +  + ++T
Sbjct: 282 LNLDSNKLTNISQET 296


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 56/176 (31%), Positives = 86/176 (48%), Gaps = 10/176 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C+C  +TV C    L ++P  +P+NT       N I +I K DFA L  L+ + L  N I
Sbjct: 32  CSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKI 91

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPEL----PTTLTFIDISNNRLGRKGIKQEAFKD 235
           S I+  AF+ L +L  L L  N ++  PEL       L  +D+S N++  + I ++AF+ 
Sbjct: 92  STIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQI--QAIPRKAFRG 149

Query: 236 MYDLHHLYLTDNNLDHI---PLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIR 288
             D+ +L L  N +  I         +L  L L NNNI  +   +F ++  L   R
Sbjct: 150 AVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFR 205



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 66/191 (34%), Positives = 95/191 (49%), Gaps = 19/191 (9%)

Query: 99  QEPEFTGVLGPHTNEDFPTCLL------CTCISTTVYCDDHELDAIPP-LPKNTAYFYSR 151
           Q+ EF  V   H +   P+C +      CTC +  V C    L  IP  LP+        
Sbjct: 251 QKREF--VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLE 308

Query: 152 FNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP---- 207
            N IK I    F+    L+RIDL++N ISE+  DAF+ L  L  LVL  NKI +LP    
Sbjct: 309 QNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLF 368

Query: 208 ELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRA---LH 264
           E   +L  + ++ N++    ++ +AF+D+++L+ L L DN L  I       LRA   +H
Sbjct: 369 EGLFSLQLLLLNANKI--NCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMH 426

Query: 265 L-QNNNILEMH 274
           L QN  I + H
Sbjct: 427 LAQNPFICDCH 437



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 37/134 (27%), Positives = 65/134 (48%), Gaps = 8/134 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           CTC+ T V C +  L  +P  +P++    Y   N+   + K + ++   L  IDL++N I
Sbjct: 731 CTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRI 789

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S +   +F  + QL  L+L  N++R +P        +L  + +  N +    + + AF D
Sbjct: 790 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI--SVVPEGAFND 847

Query: 236 MYDLHHLYLTDNNL 249
           +  L HL +  N L
Sbjct: 848 LSALSHLAIGANPL 861



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 41/168 (24%), Positives = 72/168 (42%), Gaps = 49/168 (29%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C  TTV C + +L+ IP  +P+ TA          ++N N+F  L             
Sbjct: 510 CRCEGTTVDCSNQKLNKIPEHIPQYTAEL--------RLNNNEFTVLEAT---------- 551

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDL 239
                  F+KLPQLR++   +NKI                        I++ AF+    +
Sbjct: 552 -----GIFKKLPQLRKINFSNNKITD----------------------IEEGAFEGASGV 584

Query: 240 HHLYLTDNNLDHIPLPL---PENLRALHLQNNNILEMHEDTFCNVKNL 284
           + + LT N L+++   +    E+L+ L L++N I  +  D+F  + ++
Sbjct: 585 NEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSV 632



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 19/51 (37%), Positives = 28/51 (54%)

Query: 153 NRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           NR++ +    F  L  LK + L SN I+ +  D+F  L  +R L L DN+I
Sbjct: 592 NRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQI 642



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 16/52 (30%), Positives = 28/52 (53%)

Query: 152 FNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           +N+I  I    F +L DL+ + L +N I+ +   +F  +P+LR   L  N +
Sbjct: 160 YNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNL 211


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 53/176 (30%), Positives = 90/176 (51%), Gaps = 10/176 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           CT  +  V C    L A+P  +P  T       NRI+ +N  D A+L  L+ +DL+ N I
Sbjct: 31  CTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAI 90

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELPTT----LTFIDISNNRLGRKGIKQEAFKD 235
           + ++  AF  LP+LR L LR N+++ +P    T    LT +D+S N+L    +    F+D
Sbjct: 91  AHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKL--VILLDYTFQD 148

Query: 236 MYDLHHLYLTDNNLDHIPLPLPENLRALH---LQNNNILEMHEDTFCNVKNLTYIR 288
           ++ L  L + DN+L  +       L AL    L+  N+  +  ++  ++++L  +R
Sbjct: 149 LHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALR 204



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 40/156 (25%), Positives = 72/156 (46%), Gaps = 20/156 (12%)

Query: 155 IKKINKNDFASLSDLKRIDLTS-NLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTT- 212
           I  +   +F  L  L  +++ +  L+ E+   + R L  L  L +    I  +P      
Sbjct: 210 IASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRH 268

Query: 213 ---LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIP----LPLPENLRALHL 265
              LT +++S+N +    + + +F+D+  L  L+L    L  +     L L + +R L+L
Sbjct: 269 QAHLTCLNLSHNPIST--VPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQ-IRLLNL 325

Query: 266 QNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPI 301
            NN +  + E TF +V         LE +R+DGNP+
Sbjct: 326 SNNLLSTLEESTFHSV-------NTLETLRVDGNPL 354


>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
           sapiens]
          Length = 516

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 55/172 (31%), Positives = 81/172 (47%), Gaps = 10/172 (5%)

Query: 121 CTCISTTVYCDDHELDAIP-PLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C     YCD     ++P    K +     R N I ++ ++ FAS S L  + L  N I
Sbjct: 38  CRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQI 97

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELPTT----LTFIDISNNRLGRKGIKQEAFKD 235
           S + EDAF+ L +L+EL+L  NKI  LP    T    L  +D+S N+L    +  E F  
Sbjct: 98  STVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQL--SSLHPELFYG 155

Query: 236 MYDLHHLYLTDNNLDHIPLPL---PENLRALHLQNNNILEMHEDTFCNVKNL 284
           +  L  L+L  N+L  IP+ L     +L  L L  N +  +  + F  +  L
Sbjct: 156 LRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKL 207



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 34/115 (29%), Positives = 59/115 (51%), Gaps = 6/115 (5%)

Query: 153 NRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL----PE 208
           NR++ + +N FA L  L+ + L  N +++I+   F +L  L  L L+ NKI  L      
Sbjct: 191 NRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEW 250

Query: 209 LPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRAL 263
              TL  +D++ N +  K I    F+ M +L  L + +N L+ +   +  +LR+L
Sbjct: 251 TWGTLEKLDLTGNEI--KAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSL 303



 Score = 35.0 bits (79), Expect = 0.090
 Identities = 17/58 (29%), Positives = 32/58 (55%)

Query: 149 YSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL 206
           + ++N+I  +      +   L+++DLT N I  ID   F  +P L+ L++ +NK+  L
Sbjct: 235 FLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSL 292



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 39/149 (26%), Positives = 65/149 (43%), Gaps = 19/149 (12%)

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIR------ 204
           R N ++ I    F     L+ +DL++N +  +  + F  L +LREL L  N++       
Sbjct: 165 RSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAH 224

Query: 205 --QLPELPTT-LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPE--- 258
             +L  L T  L +  ISN   G +            L  L LT N +  I L + E   
Sbjct: 225 FLRLSSLHTLFLQWNKISNLTCGMEW-------TWGTLEKLDLTGNEIKAIDLTVFETMP 277

Query: 259 NLRALHLQNNNILEMHEDTFCNVKNLTYI 287
           NL+ L + NN +  +      ++++LT +
Sbjct: 278 NLKILLMDNNKLNSLDSKILNSLRSLTTV 306


>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
          Length = 510

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 55/181 (30%), Positives = 89/181 (49%), Gaps = 29/181 (16%)

Query: 119 LLCTCIST-TVYCDDHELDAIPPLPKNTAYFYS-RFNRIKKINKNDFASLSDLKRIDLTS 176
           L C+C    TV CD  +L   P      A   S + N+++++  N+ + LS L+ ++L +
Sbjct: 46  LRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHN 105

Query: 177 NLISE--IDEDAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDIS-------------- 219
           NLIS   + ++AF  L QL+ L +  NK+   P+ LP +L   D++              
Sbjct: 106 NLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGE 165

Query: 220 ----------NNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNN 269
                     NN+L   G+  +AF+    +  L L++N L ++P  LP +L  LHLQNN 
Sbjct: 166 KPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNL 225

Query: 270 I 270
           I
Sbjct: 226 I 226



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 28/192 (14%)

Query: 127 TVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--ID 183
           T+   +++L  +PP LP +    + + N I K+ +   +  + L+ + L  N +++  +D
Sbjct: 197 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 256

Query: 184 EDAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNR-------------------- 222
              F KL  L  L L  N++  +P  LP TL  + +  NR                    
Sbjct: 257 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLL 316

Query: 223 ----LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTF 278
               LG  G+   A + +  LH L+L  N LD +P  LP  LRAL L +N++  +     
Sbjct: 317 QHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDL 376

Query: 279 CNVKNLTYIRKA 290
                LT +  A
Sbjct: 377 VATPGLTELNLA 388



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 12/122 (9%)

Query: 194 RELVLRDNKIRQLP--ELP--TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNL 249
           + L L++N++++LP  EL   + L  +++ NN +  +G+  EAF+ +  L HL +  N L
Sbjct: 75  QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKL 134

Query: 250 DHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPI-NLSKTPQ 308
              P  LP +LR   L  N ++E+   TF         + AL  + L  N + N    P 
Sbjct: 135 SVAPQFLPRSLRVADLAANQVMEIFPLTFGE-------KPALRSVYLHNNQLSNAGLPPD 187

Query: 309 AY 310
           A+
Sbjct: 188 AF 189



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 62/272 (22%), Positives = 108/272 (39%), Gaps = 34/272 (12%)

Query: 58  IATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPT 117
           IAT+  S N+    PP  P   +    +     ++  G+  ++ +   +   H N+   +
Sbjct: 195 IATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQH-NQLTDS 253

Query: 118 CLLCTCIS---TTVYCD--DHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKR 171
            L  T  S   +  Y D   ++L  +P  LP+  A  +   NRI+++          L+ 
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313

Query: 172 IDLTSNLI--SEIDEDAFRKLPQLRELVLRDNKIRQLP---------------------- 207
           + L  N +  S +   A R L  L  L L  N + ++P                      
Sbjct: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 373

Query: 208 -ELPTT--LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALH 264
            +L  T  LT ++++ NRL    +   AF+ +  L  L L  N L  +P+ LP  LR L 
Sbjct: 374 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 433

Query: 265 LQNNNILEMHEDTFCNVKNLTYIRKALEDIRL 296
           LQ N +  +  +    +  L  +  A   +R+
Sbjct: 434 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465


>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
          Length = 512

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 55/181 (30%), Positives = 89/181 (49%), Gaps = 29/181 (16%)

Query: 119 LLCTCIST-TVYCDDHELDAIPPLPKNTAYFYS-RFNRIKKINKNDFASLSDLKRIDLTS 176
           L C+C    TV CD  +L   P      A   S + N+++++  N+ + LS L+ ++L +
Sbjct: 48  LRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHN 107

Query: 177 NLISE--IDEDAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDIS-------------- 219
           NLIS   + ++AF  L QL+ L +  NK+   P+ LP +L   D++              
Sbjct: 108 NLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGE 167

Query: 220 ----------NNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNN 269
                     NN+L   G+  +AF+    +  L L++N L ++P  LP +L  LHLQNN 
Sbjct: 168 KPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNL 227

Query: 270 I 270
           I
Sbjct: 228 I 228



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 28/192 (14%)

Query: 127 TVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--ID 183
           T+   +++L  +PP LP +    + + N I K+ +   +  + L+ + L  N +++  +D
Sbjct: 199 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 258

Query: 184 EDAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNR-------------------- 222
              F KL  L  L L  N++  +P  LP TL  + +  NR                    
Sbjct: 259 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLL 318

Query: 223 ----LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTF 278
               LG  G+   A + +  LH L+L  N LD +P  LP  LRAL L +N++  +     
Sbjct: 319 QHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDL 378

Query: 279 CNVKNLTYIRKA 290
                LT +  A
Sbjct: 379 VATPGLTELNLA 390



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/122 (29%), Positives = 61/122 (50%), Gaps = 12/122 (9%)

Query: 194 RELVLRDNKIRQLP--ELP--TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNL 249
           + L L++N++++LP  EL   + L  +++ NN +  +G+  EAF+ +  L HL +  N L
Sbjct: 77  QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKL 136

Query: 250 DHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPI-NLSKTPQ 308
              P  LP +LR   L  N ++E+   TF         + AL  + L  N + N    P 
Sbjct: 137 SVAPQFLPRSLRVADLAANQVMEIFPLTFGE-------KPALRSVYLHNNQLSNAGLPPD 189

Query: 309 AY 310
           A+
Sbjct: 190 AF 191



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 62/272 (22%), Positives = 108/272 (39%), Gaps = 34/272 (12%)

Query: 58  IATVMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPT 117
           IAT+  S N+    PP  P   +    +     ++  G+  ++ +   +   H N+   +
Sbjct: 197 IATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQH-NQLTDS 255

Query: 118 CLLCTCIS---TTVYCD--DHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKR 171
            L  T  S   +  Y D   ++L  +P  LP+  A  +   NRI+++          L+ 
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 315

Query: 172 IDLTSNLI--SEIDEDAFRKLPQLRELVLRDNKIRQLP---------------------- 207
           + L  N +  S +   A R L  L  L L  N + ++P                      
Sbjct: 316 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 375

Query: 208 -ELPTT--LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALH 264
            +L  T  LT ++++ NRL    +   AF+ +  L  L L  N L  +P+ LP  LR L 
Sbjct: 376 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 435

Query: 265 LQNNNILEMHEDTFCNVKNLTYIRKALEDIRL 296
           LQ N +  +  +    +  L  +  A   +R+
Sbjct: 436 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 467


>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
           sapiens]
          Length = 581

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 61/245 (24%), Positives = 103/245 (42%), Gaps = 51/245 (20%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C C    VYC+  +L  IP  +         R+N ++K+  N F  L+ L  + L  N I
Sbjct: 38  CRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHI 97

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELP----TTLTFIDISNNRLGRKGIKQEAFKD 235
           S IDE+AF  + +L+EL+L  N+I           T L  +D+S N+L   G   E F+ 
Sbjct: 98  SNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLG--SEQFRG 155

Query: 236 MYDLHHLYLTDNNLDHIPLPLPEN---------------------------LRALHLQNN 268
           +  L  L+L  N+L  IP+ + ++                           L+ LHL++N
Sbjct: 156 LRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHN 215

Query: 269 NILEMHEDTFCNV-----------------KNLTYIRKALEDIRLDGNPINLSKTPQAYM 311
              +++   F  +                 + +++   +L+ + L GN I     P  + 
Sbjct: 216 QFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQ 275

Query: 312 CLPRL 316
           C+P L
Sbjct: 276 CVPNL 280



 Score = 30.4 bits (67), Expect = 2.2
 Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 3/74 (4%)

Query: 149 YSRFNRIKKINKNDFASLSDLKRIDLTSNLISEID-EDAFRKLPQLRELVLRDNKIRQLP 207
           Y ++N+I  I +    + S L+R+DL+ N I        F+ +P L+ L L  NK+  + 
Sbjct: 235 YLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIG 294

Query: 208 E--LPTTLTFIDIS 219
           +  L + ++  DIS
Sbjct: 295 QEILDSWISLNDIS 308



 Score = 28.9 bits (63), Expect = 6.4
 Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 21/159 (13%)

Query: 151 RFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQL---- 206
           R N ++ I    F    +L+ +DL  N I  +  + F  + +L+EL L  N+  +L    
Sbjct: 165 RSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLAL 224

Query: 207 -PELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLP----LPENLR 261
            P L  +L  + +  N++   G  Q        L  L L+ N ++    P       NL+
Sbjct: 225 FPRL-VSLQNLYLQWNKISVIG--QTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQ 281

Query: 262 ALHLQNNNILEMHEDTFCNVKNL-TYIRKALEDIRLDGN 299
            L+L +N +      TF   + L ++I  +L DI L GN
Sbjct: 282 RLNLDSNKL------TFIGQEILDSWI--SLNDISLAGN 312


>gi|71040111 fibromodulin precursor [Homo sapiens]
          Length = 376

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 60/230 (26%), Positives = 102/230 (44%), Gaps = 33/230 (14%)

Query: 121 CTC---ISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSN 177
           C C     T +YCD+  L  +P +P    Y Y + N+I  I +  F + + L  I L  N
Sbjct: 80  CDCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGN 139

Query: 178 LIS--EIDEDAFRKLPQLRELVLRDNKIRQLP-ELPTTLTFIDISNNRLGR------KGI 228
            I+  ++    F KL  L  L L  N + ++P  LP +L  + + +N++ R      +G+
Sbjct: 140 QITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGL 199

Query: 229 K------------QEAFKDMYDLHHLYLTD---NNLDHIPLPLPENLRALHLQNNNILEM 273
           +            QE    M  L  L L D   N+L  +P  LP  L  L++++NN+  +
Sbjct: 200 ENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTV 259

Query: 274 HEDTFCNVKNLTYIRKALEDIRLDG------NPINLSKTPQAYMCLPRLP 317
            +  F     L Y+R +   +  +G      N  +L +   +Y  L ++P
Sbjct: 260 PDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIP 309



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 61/212 (28%), Positives = 93/212 (43%), Gaps = 29/212 (13%)

Query: 128 VYCDDHELDAIP-PLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDA 186
           +Y D + L  +P PLP++    +   N+I ++  N    L +L  + L  N I E+    
Sbjct: 160 LYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGSSM 219

Query: 187 ---------------FRKLPQ-----LRELVLRDNKIRQLPEL----PTTLTFIDISNNR 222
                           RK+P      L +L +  N +  +P+        L ++ +S+N 
Sbjct: 220 RGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNS 279

Query: 223 LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVK 282
           L   G+    F     L  L L+ N L  IP P+  NL  L+LQ N I E    +FC V 
Sbjct: 280 LTNNGLASNTFNSS-SLLELDLSYNQLQKIP-PVNTNLENLYLQGNRINEFSISSFCTVV 337

Query: 283 NLTYIRKALEDIRLDGNPINLSKTP-QAYMCL 313
           ++    K L+ +RLDGN I  S  P  A +CL
Sbjct: 338 DVVNFSK-LQVLRLDGNEIKRSAMPADAPLCL 368


>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
          Length = 620

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 51/176 (28%), Positives = 86/176 (48%), Gaps = 10/176 (5%)

Query: 121 CTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI 179
           C+     V C      A+P  +P  T       NRIK +N+++FAS   L+ ++L  N++
Sbjct: 48  CSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIV 107

Query: 180 SEIDEDAFRKLPQLRELVLRDNKIRQLPELPTT----LTFIDISNNRLGRKGIKQEAFKD 235
           S ++  AF  L  LR L LR N+++ +P    T    LT +DIS N++    +    F+D
Sbjct: 108 SAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI--VILLDYMFQD 165

Query: 236 MYDLHHLYLTDNNL---DHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIR 288
           +Y+L  L + DN+L    H       +L  L L+  N+  +  +   ++  L  +R
Sbjct: 166 LYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLR 221


>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
          Length = 699

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 71/262 (27%), Positives = 110/262 (41%), Gaps = 38/262 (14%)

Query: 63  PSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFP-----T 117
           P   R L     +  + +EE+EEEE      D    ++P    +    +    P     T
Sbjct: 254 PGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRMPSRSPLPAPPRGT 313

Query: 118 CLL---CTCISTTVYCDDHELDAIPPL--PKNTAYFYSRFNRIKKINKNDFASLSDLKRI 172
             L   C+    T+ C +  L  IPPL  P+ T+   +  N I  I    F  L +L+R+
Sbjct: 314 LRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTG-NSIASIPDEAFNGLPNLERL 372

Query: 173 DLTSNLI--SEIDEDAFRKLPQLRELVLRDNKIRQLP-ELPTTL---------------- 213
           DL+ N I  S I   AF+ L +L  L +  N + Q+P +LP+TL                
Sbjct: 373 DLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEE 432

Query: 214 --------TFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHL 265
                     +++  N L    +   AFK +  L +L L  N    IP  LP ++  L+L
Sbjct: 433 SLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYL 492

Query: 266 QNNNILEMHEDTFCNVKNLTYI 287
           +NN I E+ E  F + + +  I
Sbjct: 493 ENNQIEEITEICFNHTRKINVI 514



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 46/197 (23%), Positives = 85/197 (43%), Gaps = 29/197 (14%)

Query: 131 DDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE-------- 181
           D + L  IP  LP          N ++ I++   + L+ L  ++L  N +SE        
Sbjct: 401 DGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAF 460

Query: 182 ----------IDEDAFRKLPQ-----LRELVLRDNKIRQLPEL----PTTLTFIDISNNR 222
                     + ++ FR +PQ     + EL L +N+I ++ E+       +  I +  N+
Sbjct: 461 KPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNK 520

Query: 223 LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVK 282
           +    I   A+ +  +L  + L+ N L H+P  LP++L  L L  N I  +    F +++
Sbjct: 521 IEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHME 580

Query: 283 -NLTYIRKALEDIRLDG 298
             L Y+  +   +  DG
Sbjct: 581 PGLEYLYLSFNKLADDG 597


>gi|45505137 podocan [Homo sapiens]
          Length = 661

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 28/186 (15%)

Query: 127 TVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS--EID 183
           TV+  ++ L+ +P  LP+         N+I  I + DFA+   L+ ++L+ N I+  ++ 
Sbjct: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470

Query: 184 EDAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDI------------------------ 218
            DAFRKL  LR L L  N++  LP  LP  +  + +                        
Sbjct: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530

Query: 219 SNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTF 278
           ++NRL  + +   A+ D+  L  L +  N L  IP  LPE+L  L+LQNN I  +  + F
Sbjct: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAF 590

Query: 279 CNVKNL 284
            +  NL
Sbjct: 591 DSTPNL 596



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 60/226 (26%), Positives = 96/226 (42%), Gaps = 38/226 (16%)

Query: 97  SPQEPEFTG-----VLGPHTNEDFPTCLLCT--CIST---TVYCDDHELDAIP-PLPKNT 145
           SP+E EF       VL P      P  + C   C  +    V C   +L   P  LP++T
Sbjct: 87  SPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHT 146

Query: 146 AYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--IDEDAFRKLPQLRELVLRDNKI 203
            +   + N+++KI   + + L  L+ ++L +N ++   + E AF  L  L  L L +NK+
Sbjct: 147 NHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL 206

Query: 204 RQLPE-LPTTLTFIDIS------------------------NNRLGRKGIKQEAFKDMYD 238
              P  LP  L  +D +                        NN+L   G+    F    +
Sbjct: 207 TLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSN 266

Query: 239 LHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNL 284
           +  L L+ N L H+P  LP  L  LHL+NN + ++    F  + +L
Sbjct: 267 VEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSL 312



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 51/197 (25%), Positives = 90/197 (45%), Gaps = 37/197 (18%)

Query: 141 LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISE--IDEDAFRKLPQLRELVL 198
           LP      + + N+++KI    F+ LS L+ + L +N +++  +D + F KL  L  L L
Sbjct: 284 LPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDL 343

Query: 199 RDNKIRQLPE-LPTTLTFIDIS------------------------NNRLGRKGIKQEAF 233
             N + ++P  LP +L  + +                         +N+L  +GI   AF
Sbjct: 344 SSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403

Query: 234 KDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALED 293
           + +  LH ++L +N L+ +P  LP  +R L + +N I  +  + F      TY    LE+
Sbjct: 404 QGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFAT----TYF---LEE 456

Query: 294 IRLDGNPINLSKTPQAY 310
           + L  N I    +PQ +
Sbjct: 457 LNLSYNRIT---SPQVH 470



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 41/143 (28%), Positives = 74/143 (51%), Gaps = 9/143 (6%)

Query: 161 NDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP-----ELPTTLTF 215
           N F   S+++ + L+SN +  + +      P L +L L++NK+ ++P     EL ++L  
Sbjct: 259 NMFNGSSNVEVLILSSNFLRHVPKHL---PPALYKLHLKNNKLEKIPPGAFSEL-SSLRE 314

Query: 216 IDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHE 275
           + + NN L  +G+  E F  +  L +L L+ NNL  +P  LP +L  LHL+ N I  +  
Sbjct: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374

Query: 276 DTFCNVKNLTYIRKALEDIRLDG 298
           +    +++L Y+      +R  G
Sbjct: 375 NVLTPIRSLEYLLLHSNQLREQG 397



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 213 LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILE 272
           L  +++ NNRL  +G+ ++AF+ + +L++LYL +N L   P  LP  L ++    N + +
Sbjct: 170 LETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTK 229

Query: 273 MHEDTFCNVKNLTYI---RKALEDIRLDGNPIN 302
           ++  TF    NL  +      L D  L  N  N
Sbjct: 230 IYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 15/102 (14%)

Query: 133 HELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSN--LISEIDEDAFRK 189
           ++L  IP  LP++  Y Y + N+I  +  N F S  +LK I L  N   +  + + AFR+
Sbjct: 559 NQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRR 618

Query: 190 LPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQE 231
           L  L+ L +  N           L F DIS +R GR G ++E
Sbjct: 619 LKHLQVLDIEGN-----------LEFGDISKDR-GRLGKEKE 648


>gi|4502403 biglycan preproprotein [Homo sapiens]
          Length = 368

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 61/239 (25%), Positives = 104/239 (43%), Gaps = 30/239 (12%)

Query: 90  PRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL---CTCISTTVYCDDHELDAIPP-LPKNT 145
           P +++       + +GVL P +     + +    C C    V C D  L ++P  +  +T
Sbjct: 33  PFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDT 92

Query: 146 AYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQ 205
                + N I ++ K+DF  L  L  + L +N IS+I E AF  L +L++L +  N + +
Sbjct: 93  TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVE 152

Query: 206 LP-ELPTTLTFIDISNNRLGR------------------------KGIKQEAFKDMYDLH 240
           +P  LP++L  + I +NR+ +                         G +  AF D   L+
Sbjct: 153 IPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAF-DGLKLN 211

Query: 241 HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGN 299
           +L +++  L  IP  LPE L  LHL +N I  +  +       L  +      IR+  N
Sbjct: 212 YLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIEN 270



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 55/215 (25%), Positives = 96/215 (44%), Gaps = 31/215 (14%)

Query: 128 VYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLI--SEIDE 184
           +Y   + L  IPP LP +        NRI+K+ K  F+ L ++  I++  N +  S  + 
Sbjct: 143 LYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEP 202

Query: 185 DAFRKLPQLRELVLRDNKIRQLP-ELPTTLTFIDISNNR--------------LGRKG-- 227
            AF  L +L  L + + K+  +P +LP TL  + + +N+              L R G  
Sbjct: 203 GAFDGL-KLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLG 261

Query: 228 ------IKQEAFKDMYDLHHLYLTDNNLDHIPLPLPEN--LRALHLQNNNILEMHEDTFC 279
                 I+  +   +  L  L+L +N L  +P  LP+   L+ ++L +NNI ++  + FC
Sbjct: 262 HNQIRMIENGSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFC 321

Query: 280 NVKNLTYIRKALEDIRLDGNPINLSKT-PQAYMCL 313
            +      R     I L  NP+   +  P  + C+
Sbjct: 322 PM-GFGVKRAYYNGISLFNNPVPYWEVQPATFRCV 355


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 55/187 (29%), Positives = 82/187 (43%), Gaps = 38/187 (20%)

Query: 121 CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS 180
           C C  +TV C    LD IP +P+ T     RFNRI++I  + F  L +L  + L +N I 
Sbjct: 28  CLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIR 87

Query: 181 EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH 240
           +I  +AF  L  L  L L  N+I  L                       ++ FK +  L 
Sbjct: 88  KISRNAFEGLENLLYLYLYKNEIHAL----------------------DKQTFKGLISLE 125

Query: 241 HLYLTDNNLDHIPLPLPE------NLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDI 294
           HLY+  N L+ +    PE       L  L L NN + ++   +F N+        +L+ +
Sbjct: 126 HLYIHFNQLEMLQ---PETFGDLLRLERLFLHNNKLSKIPAGSFSNL-------DSLKRL 175

Query: 295 RLDGNPI 301
           RLD N +
Sbjct: 176 RLDSNAL 182


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 63/196 (32%), Positives = 97/196 (49%), Gaps = 23/196 (11%)

Query: 114 DFPTC-LLCTCISTTVYCDDHELDAIPP-LPKNTAYFYSRFNRIKKINKNDFASLSDLK- 170
           D  TC  +C C +  +YC+D  L +IP  +P +    Y + N+I     N+     DLK 
Sbjct: 50  DSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQI-----NNAGIPQDLKT 104

Query: 171 RIDLTSNLISEIDEDAFR-KLPQ-LRELVLRDNKIR-----QLPELPTTLTFIDISNNRL 223
           ++++    + E D D F   LP+ LREL L+DN +R      L  +P  L  + + +N +
Sbjct: 105 KVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPL-LEKLHLDDNSV 163

Query: 224 GRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKN 283
               I+++AF D   L  L+L+ N+L  IP  LP  L  L L +N I  +    F   K 
Sbjct: 164 STVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAF---KG 220

Query: 284 LTYIRKALEDIRLDGN 299
           L  +R+ +    LDGN
Sbjct: 221 LNSLRRLV----LDGN 232



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 56/210 (26%), Positives = 96/210 (45%), Gaps = 38/210 (18%)

Query: 128 VYCDDHELDAIP-PLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS--EIDE 184
           +Y  +++LD  P  LP++    + + N ++ I ++  A +  L+++ L  N +S   I+E
Sbjct: 111 IYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEE 170

Query: 185 DAFRKLPQLRELVLRDNKIRQLPE-LPTTLTFIDISNNR--------------------- 222
           DAF    QL+ L L  N +  +P  LP TL  + + +NR                     
Sbjct: 171 DAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLD 230

Query: 223 ---LGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPE-NLRALHLQNNNILEMHEDTF 278
              L  + I  + F  + +L  L L  N+L   PL LP  +L+ L+LQ+N I  +  +T 
Sbjct: 231 GNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTL 290

Query: 279 CNVKNLTYIRKALEDIRLDGNPINLSKTPQ 308
             ++ L          RLD +  NL+  P+
Sbjct: 291 AKMRELE---------RLDLSNNNLTTLPR 311



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 32/104 (30%), Positives = 56/104 (53%), Gaps = 9/104 (8%)

Query: 200 DNKIRQLP-ELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPE 258
           D  +  +P ++P   T + + NN++   GI Q+  K   ++  +YL +N+LD  P+ LP 
Sbjct: 69  DRGLTSIPADIPDDATTLYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDLDEFPINLPR 127

Query: 259 NLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPIN 302
           +LR LHLQ+NN+  +  D+   +         LE + LD N ++
Sbjct: 128 SLRELHLQDNNVRTIARDSLARI-------PLLEKLHLDDNSVS 164



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 3/68 (4%)

Query: 137 AIPPLPKNTAYF---YSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQL 193
           A PPL   +A+    Y + N I  I  N  A + +L+R+DL++N ++ +    F  L  L
Sbjct: 261 AAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNL 320

Query: 194 RELVLRDN 201
            +L+LR+N
Sbjct: 321 AQLLLRNN 328


>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
           sapiens]
          Length = 757

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 57/186 (30%), Positives = 89/186 (47%), Gaps = 16/186 (8%)

Query: 116 PTCLL------CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDL 169
           P CL+      C C    + CD+  L A+P +  N      ++N I+K+  + F +  DL
Sbjct: 93  PECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDL 152

Query: 170 KRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP----ELPTTLTFIDISNNRLGR 225
           +++ L +N I+ I   AFR L  L +L L  N+I  L     E    L ++ I +N L R
Sbjct: 153 QKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSR 212

Query: 226 KGIKQEAFKDMYDLHHLYLTDNNLDHIP-LPLPENLRALH---LQNNNILEMHEDTFCNV 281
             I    F  +  L  L L +N L  +P  PL +++  LH   L+ N+I  +   TF + 
Sbjct: 213 --ISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISC 270

Query: 282 KNLTYI 287
            NLT +
Sbjct: 271 SNLTVL 276



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 30/102 (29%), Positives = 48/102 (47%), Gaps = 2/102 (1%)

Query: 144 NTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKI 203
           N      R N+I  +N+N FA L  L  +DL SN I  +    F+ L +L +L L  N I
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPI 331

Query: 204 R--QLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLY 243
           +  Q  +    +    +S   +    I+Q  F+ + +L H+Y
Sbjct: 332 QKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIY 373



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 25/138 (18%)

Query: 153 NRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTT 212
           N I  +    F S S+L  + +  N I+ ++E+ F  L +L EL L  NKI  LP L   
Sbjct: 257 NHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPL--- 313

Query: 213 LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHI---PLPLPENLRALHLQNNN 269
                               FKD+ +L  L L+ N +  I          L++L L+   
Sbjct: 314 -------------------IFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIE 354

Query: 270 ILEMHEDTFCNVKNLTYI 287
           I  + +  F  + NL++I
Sbjct: 355 ISNIQQRMFRPLMNLSHI 372


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.137    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,812,575
Number of Sequences: 37866
Number of extensions: 713890
Number of successful extensions: 6879
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 5382
Number of HSP's gapped (non-prelim): 916
length of query: 322
length of database: 18,247,518
effective HSP length: 102
effective length of query: 220
effective length of database: 14,385,186
effective search space: 3164740920
effective search space used: 3164740920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.