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Search of human proteins with 66912176
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66912176 leucine rich repeat containing 66 [Homo sapiens]
(880 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66912176 leucine rich repeat containing 66 [Homo sapiens] 1786 0.0
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 77 7e-14
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 77 7e-14
gi|27363458 leucine rich repeat and fibronectin type III domain ... 70 1e-11
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 67 6e-11
gi|13375646 leucine rich repeat and fibronectin type III domain ... 66 2e-10
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 64 5e-10
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 64 5e-10
gi|198041768 synleurin [Homo sapiens] 64 8e-10
gi|31542244 leucine rich repeat and fibronectin type III domain ... 62 2e-09
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] 62 2e-09
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 62 2e-09
gi|55741571 leucine rich repeat and fibronectin type III domain ... 61 4e-09
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 61 4e-09
gi|11321571 slit homolog 3 [Homo sapiens] 61 5e-09
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 61 5e-09
gi|4759146 slit homolog 2 [Homo sapiens] 60 7e-09
gi|45505137 podocan [Homo sapiens] 60 9e-09
gi|188528675 slit homolog 1 [Homo sapiens] 60 1e-08
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 59 2e-08
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 59 2e-08
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 59 2e-08
gi|126517478 peroxidasin homolog-like [Homo sapiens] 59 3e-08
gi|149773484 leucine rich repeat and fibronectin type III domain... 58 4e-08
gi|225579152 insulin-like growth factor binding protein, acid la... 57 6e-08
gi|4826772 insulin-like growth factor binding protein, acid labi... 57 6e-08
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 57 6e-08
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 57 8e-08
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 57 8e-08
gi|16751843 toll-like receptor 5 [Homo sapiens] 57 8e-08
>gi|66912176 leucine rich repeat containing 66 [Homo sapiens]
Length = 880
Score = 1786 bits (4626), Expect = 0.0
Identities = 880/880 (100%), Positives = 880/880 (100%)
Query: 1 MKNLYFRVITIVIGLYFTGIMTNASRKSNILFNSECQWNEYILTNCSFTGKCDIPVDISQ 60
MKNLYFRVITIVIGLYFTGIMTNASRKSNILFNSECQWNEYILTNCSFTGKCDIPVDISQ
Sbjct: 1 MKNLYFRVITIVIGLYFTGIMTNASRKSNILFNSECQWNEYILTNCSFTGKCDIPVDISQ 60
Query: 61 TAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNA 120
TAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNA
Sbjct: 61 TAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNA 120
Query: 121 IHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSF 180
IHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSF
Sbjct: 121 IHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSF 180
Query: 181 NGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMII 240
NGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMII
Sbjct: 181 NGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMII 240
Query: 241 ALEFPHLVVDLADNNWQCDDSVAVFQNFISESWRKKWNVICNRSIGSEEANGGTPQSRIS 300
ALEFPHLVVDLADNNWQCDDSVAVFQNFISESWRKKWNVICNRSIGSEEANGGTPQSRIS
Sbjct: 241 ALEFPHLVVDLADNNWQCDDSVAVFQNFISESWRKKWNVICNRSIGSEEANGGTPQSRIS 300
Query: 301 RETRLPPIHLHRMKSLIRSKAERPQGGRHTGISTLGKKAKAGSGLRKKQRRLPRSVRSTR 360
RETRLPPIHLHRMKSLIRSKAERPQGGRHTGISTLGKKAKAGSGLRKKQRRLPRSVRSTR
Sbjct: 301 RETRLPPIHLHRMKSLIRSKAERPQGGRHTGISTLGKKAKAGSGLRKKQRRLPRSVRSTR 360
Query: 361 DVQAAGKKEDAPQDLALAVCLSVFITFLVAFSLGAFTRPYVDRLWQKKCQSKSPGLDNAY 420
DVQAAGKKEDAPQDLALAVCLSVFITFLVAFSLGAFTRPYVDRLWQKKCQSKSPGLDNAY
Sbjct: 361 DVQAAGKKEDAPQDLALAVCLSVFITFLVAFSLGAFTRPYVDRLWQKKCQSKSPGLDNAY 420
Query: 421 SNEGFYDDMEAAGHTPHPETHLRQVFPHLSLYENQTPFWVTQPHPHATVIPDRTLGRSRK 480
SNEGFYDDMEAAGHTPHPETHLRQVFPHLSLYENQTPFWVTQPHPHATVIPDRTLGRSRK
Sbjct: 421 SNEGFYDDMEAAGHTPHPETHLRQVFPHLSLYENQTPFWVTQPHPHATVIPDRTLGRSRK 480
Query: 481 DPGSSQSPGQCGDNTGAGSGNDGAVYSILQRHPHAGNRELMSAAQDHIHRNDILGEWTYE 540
DPGSSQSPGQCGDNTGAGSGNDGAVYSILQRHPHAGNRELMSAAQDHIHRNDILGEWTYE
Sbjct: 481 DPGSSQSPGQCGDNTGAGSGNDGAVYSILQRHPHAGNRELMSAAQDHIHRNDILGEWTYE 540
Query: 541 TVAQEEPLSAHSVGVSSVAGTSHAVSGSSRYDSNELDPSLSGEITASLCKMLTHAEAQRT 600
TVAQEEPLSAHSVGVSSVAGTSHAVSGSSRYDSNELDPSLSGEITASLCKMLTHAEAQRT
Sbjct: 541 TVAQEEPLSAHSVGVSSVAGTSHAVSGSSRYDSNELDPSLSGEITASLCKMLTHAEAQRT 600
Query: 601 GDSKERGGTEQSLWDSQMEFSKERQVSSSIDLLSIQQPRLSGARAEEALSAHYSEVPYGD 660
GDSKERGGTEQSLWDSQMEFSKERQVSSSIDLLSIQQPRLSGARAEEALSAHYSEVPYGD
Sbjct: 601 GDSKERGGTEQSLWDSQMEFSKERQVSSSIDLLSIQQPRLSGARAEEALSAHYSEVPYGD 660
Query: 661 PRDTGPSVFPPRWDSGLDVTPANKEPVQKSTPSDTCCELESDCDSDEGSLFTLSSISSES 720
PRDTGPSVFPPRWDSGLDVTPANKEPVQKSTPSDTCCELESDCDSDEGSLFTLSSISSES
Sbjct: 661 PRDTGPSVFPPRWDSGLDVTPANKEPVQKSTPSDTCCELESDCDSDEGSLFTLSSISSES 720
Query: 721 ARSKTEEAVPDEESLQDESSGASKDNVTAVDSLEENVTFQTIPGKCKNQEDPFEKPLISA 780
ARSKTEEAVPDEESLQDESSGASKDNVTAVDSLEENVTFQTIPGKCKNQEDPFEKPLISA
Sbjct: 721 ARSKTEEAVPDEESLQDESSGASKDNVTAVDSLEENVTFQTIPGKCKNQEDPFEKPLISA 780
Query: 781 PDSGMYKTHLENASDTDRSEGLSPWPRSPGNSPLGDEFPGMFTYDYDTALQSKAAEWHCS 840
PDSGMYKTHLENASDTDRSEGLSPWPRSPGNSPLGDEFPGMFTYDYDTALQSKAAEWHCS
Sbjct: 781 PDSGMYKTHLENASDTDRSEGLSPWPRSPGNSPLGDEFPGMFTYDYDTALQSKAAEWHCS 840
Query: 841 LRDLEFSNVDVLQQTPPCSAEVPSDPDKAAFHERDSDILK 880
LRDLEFSNVDVLQQTPPCSAEVPSDPDKAAFHERDSDILK
Sbjct: 841 LRDLEFSNVDVLQQTPPCSAEVPSDPDKAAFHERDSDILK 880
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 77.0 bits (188), Expect = 7e-14
Identities = 62/197 (31%), Positives = 97/197 (49%), Gaps = 19/197 (9%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSP----KSSWV-KRHRS 141
++ L LSNN IS++ S F L L L L N++ LSL + P + W+ H S
Sbjct: 253 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 312
Query: 142 SFRNR----FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQ 196
S + L+VLIL RN++S G + L L+ L L N + + + F
Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL----VVDLA 252
L+N+ L++N++ ++P F ++ L I L NN L LP+ I F HL + L
Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLEN-LPLGI----FDHLGKLCELRLY 427
Query: 253 DNNWQCDDSVAVFQNFI 269
DN W+CD + +N++
Sbjct: 428 DNPWRCDSDILPLRNWL 444
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/146 (34%), Positives = 70/146 (47%), Gaps = 16/146 (10%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+K L L N + I F +L L LNL N SL +SP+ V +H +
Sbjct: 157 LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN-----SLTHISPR---VFQHLGN---- 204
Query: 147 FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
L+VL L N+L+D P G + L +LQ L L N I + FHN L+ L L +N
Sbjct: 205 ---LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN 261
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNAL 231
I ++PP F L +L + L N+L
Sbjct: 262 HISQLPPSIFMQLPQLNRLTLFGNSL 287
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 17/149 (11%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
L + N +S+IT F L +L L+L+NN + L + L S
Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDS--------------- 132
Query: 150 LKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
L+ L+L N+L P + +L+ L L N + I F + + L L L N +
Sbjct: 133 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 192
Query: 209 KIPPQAFKDLKKLQVIDLSNNALITILPM 237
I P+ F+ L LQV+ L N L T +PM
Sbjct: 193 HISPRVFQHLGNLQVLRLYENRL-TDIPM 220
Score = 46.6 bits (109), Expect = 1e-04
Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 10/166 (6%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSW--VKRHRS--- 141
+++L L+NN + + + F L +LE L LS+N + + S S+ ++ H +
Sbjct: 109 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 168
Query: 142 -----SFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQ 196
+F + L K+ + + + +P+ L +LQ L L N + I F +
Sbjct: 169 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 228
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL 242
L+ L L+ N+I + P F + LQ + LSNN + + P + + L
Sbjct: 229 LQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Score = 37.0 bits (84), Expect = 0.081
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)
Query: 168 WKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLS 227
W SLQ L+ I ++ S F N L L ++ N++ +I P AF++L L+ + L+
Sbjct: 59 WNAMSLQILNTH---ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLA 115
Query: 228 NNALITILPM 237
NN L +LP+
Sbjct: 116 NNKL-QVLPI 124
Score = 35.0 bits (79), Expect = 0.31
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 2/87 (2%)
Query: 150 LKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
L++L +L+++P + +L +L + N + +I F N L L L +NK+
Sbjct: 64 LQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 121
Query: 210 IPPQAFKDLKKLQVIDLSNNALITILP 236
+P F+ L L+ + LS+N L+ I P
Sbjct: 122 LPIGLFQGLDSLESLLLSSNQLLQIQP 148
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 77.0 bits (188), Expect = 7e-14
Identities = 62/197 (31%), Positives = 97/197 (49%), Gaps = 19/197 (9%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSP----KSSWV-KRHRS 141
++ L LSNN IS++ S F L L L L N++ LSL + P + W+ H S
Sbjct: 247 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 306
Query: 142 SFRNR----FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQ 196
S + L+VLIL RN++S G + L L+ L L N + + + F
Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL----VVDLA 252
L+N+ L++N++ ++P F ++ L I L NN L LP+ I F HL + L
Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLEN-LPLGI----FDHLGKLCELRLY 421
Query: 253 DNNWQCDDSVAVFQNFI 269
DN W+CD + +N++
Sbjct: 422 DNPWRCDSDILPLRNWL 438
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/146 (34%), Positives = 70/146 (47%), Gaps = 16/146 (10%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+K L L N + I F +L L LNL N SL +SP+ V +H +
Sbjct: 151 LKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN-----SLTHISPR---VFQHLGN---- 198
Query: 147 FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
L+VL L N+L+D P G + L +LQ L L N I + FHN L+ L L +N
Sbjct: 199 ---LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN 255
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNAL 231
I ++PP F L +L + L N+L
Sbjct: 256 HISQLPPSIFMQLPQLNRLTLFGNSL 281
Score = 47.4 bits (111), Expect = 6e-05
Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 17/149 (11%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
L + N +S+IT F L +L L+L+NN + L + L S
Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDS--------------- 126
Query: 150 LKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
L+ L+L N+L P + +L+ L L N + I F + + L L L N +
Sbjct: 127 LESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLT 186
Query: 209 KIPPQAFKDLKKLQVIDLSNNALITILPM 237
I P+ F+ L LQV+ L N L T +PM
Sbjct: 187 HISPRVFQHLGNLQVLRLYENRL-TDIPM 214
Score = 46.6 bits (109), Expect = 1e-04
Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 10/166 (6%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSW--VKRHRS--- 141
+++L L+NN + + + F L +LE L LS+N + + S S+ ++ H +
Sbjct: 103 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 162
Query: 142 -----SFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQ 196
+F + L K+ + + + +P+ L +LQ L L N + I F +
Sbjct: 163 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN 222
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL 242
L+ L L+ N+I + P F + LQ + LSNN + + P + + L
Sbjct: 223 LQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Score = 37.0 bits (84), Expect = 0.081
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 4/70 (5%)
Query: 168 WKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLS 227
W SLQ L+ I ++ S F N L L ++ N++ +I P AF++L L+ + L+
Sbjct: 53 WNAMSLQILNTH---ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLA 109
Query: 228 NNALITILPM 237
NN L +LP+
Sbjct: 110 NNKL-QVLPI 118
Score = 35.0 bits (79), Expect = 0.31
Identities = 25/87 (28%), Positives = 45/87 (51%), Gaps = 2/87 (2%)
Query: 150 LKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
L++L +L+++P + +L +L + N + +I F N L L L +NK+
Sbjct: 58 LQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 115
Query: 210 IPPQAFKDLKKLQVIDLSNNALITILP 236
+P F+ L L+ + LS+N L+ I P
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQP 142
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 69.7 bits (169), Expect = 1e-11
Identities = 58/201 (28%), Positives = 92/201 (45%), Gaps = 20/201 (9%)
Query: 39 NEYILTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLIS 98
+E + T C+ G +P ++ + + ++ NF + L + + L LS N I+
Sbjct: 27 SESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVD-LTLSRNAIT 85
Query: 99 KITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL-LKVLILQR 157
+I F L +L L+L N + L L R P+ L+ LIL
Sbjct: 86 RIGARAFGDLESLRSLHLDGNRLVELGTGSL----------------RGPVNLQHLILSG 129
Query: 158 NKLSDTPKGLWK--LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAF 215
N+L G + L+SL+ LDLS+N + Q+ W+ L L L N I +PP AF
Sbjct: 130 NQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAF 189
Query: 216 KDLKKLQVIDLSNNALITILP 236
L +L +DL++N L T+ P
Sbjct: 190 AQLGQLSRLDLTSNRLATLAP 210
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 67.4 bits (163), Expect = 6e-11
Identities = 52/144 (36%), Positives = 74/144 (51%), Gaps = 16/144 (11%)
Query: 89 HLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFP 148
+LDLS N IS++ +P L LE L L+ NA+ + PK ++ +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYI------PKGAFTGLYS-------- 115
Query: 149 LLKVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI 207
LKVL+LQ N+L P + L L+SLQSL L N I + S F L +L L N +
Sbjct: 116 -LKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
Query: 208 FKIPPQAFKDLKKLQVIDLSNNAL 231
+IP QAF+ L LQ + L+ N +
Sbjct: 175 TEIPVQAFRSLSALQAMTLALNKI 198
Score = 62.4 bits (150), Expect = 2e-09
Identities = 53/188 (28%), Positives = 86/188 (45%), Gaps = 17/188 (9%)
Query: 45 NCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSP 104
+CS G ++P ++S + +D+S N LL + + ++ L L+ N ++ I
Sbjct: 51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRF-LEELRLAGNALTYIPKGA 109
Query: 105 FAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTP 164
F L++L+VL L NN + + + L S L+ L L N +S P
Sbjct: 110 FTGLYSLKVLMLQNNQLRHVPTEALQNLRS---------------LQSLRLDANHISYVP 154
Query: 165 KGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQV 223
+ L SL+ L L N + +I F + L+ + L NKI IP AF +L L V
Sbjct: 155 PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVV 214
Query: 224 IDLSNNAL 231
+ L NN +
Sbjct: 215 LHLHNNRI 222
Score = 54.3 bits (129), Expect = 5e-07
Identities = 60/210 (28%), Positives = 86/210 (40%), Gaps = 30/210 (14%)
Query: 94 NNLISKITLSPFAYLHALEVLNLSN--------NAIHSLSLDLLSPKSSWVKRHRSSFRN 145
+N I + S F +L L L L+ + + +L+ L+ + + + N
Sbjct: 290 DNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCN 349
Query: 146 RFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
+ P L+VL L N L D P + LQ +DL N I +I F L L +L L N
Sbjct: 350 QLPNLQVLDLSYNLLEDLPS-FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNALITI------------------LPMMIIALEFPHL 247
KI I P AF L L +DLS+N L + L +I + FP L
Sbjct: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPEL 468
Query: 248 VVDLADNNWQCDDSVAVFQNF--ISESWRK 275
V +QC + V +N IS W K
Sbjct: 469 KVIEMPYAYQC-CAFGVCENAYKISNQWNK 497
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 65.9 bits (159), Expect = 2e-10
Identities = 54/193 (27%), Positives = 83/193 (43%), Gaps = 18/193 (9%)
Query: 46 CSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPF 105
C G +P + + AA + ++ NF ++ + HL LS N I + F
Sbjct: 45 CPGAGLLFVPPSLDRRAAELRLADNFI-ASVRRRDLANMTGLLHLSLSRNTIRHVAAGAF 103
Query: 106 AYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPK 165
A L AL L+L N + SL L + L+ LIL N+L+
Sbjct: 104 ADLRALRALHLDGNRLTSLGEGQLRGLVN---------------LRHLILSNNQLAALAA 148
Query: 166 GLWK--LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQV 223
G ++L+ LDLS+N + Q+ W + L L N + +P AF L KL
Sbjct: 149 GALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLAR 208
Query: 224 IDLSNNALITILP 236
+D+++N L TI P
Sbjct: 209 LDMTSNRLTTIPP 221
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/86 (24%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 57 DISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNL 116
D ++T +D+S+N L + + L L +NL++ + F+ LH L L++
Sbjct: 153 DCAETLEDLDLSYNNLEQLPWEALGRLG-NVNTLGLDHNLLASVPAGAFSRLHKLARLDM 211
Query: 117 SNNAIHSLSLDLLSPKSSWVKRHRSS 142
++N + ++ D L + + R R S
Sbjct: 212 TSNRLTTIPPDPLFSRLPLLARPRGS 237
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 64.3 bits (155), Expect = 5e-10
Identities = 53/166 (31%), Positives = 78/166 (46%), Gaps = 17/166 (10%)
Query: 148 PLLKVLILQRNKLSDTPKG-LWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNK 206
PLL+ L L N++ G L L L+SLDLS N I WSD HN L+ L + SN+
Sbjct: 74 PLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNE 133
Query: 207 IFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL-EFPHLVVDLADNNWQCDDSVAVF 265
+ IP AF+ L+ L+ + L++N L T+ L HL ++ +N + C +
Sbjct: 134 LTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN--ENPFDCTCGIV-- 189
Query: 266 QNFISESWRKKWNVICNRSIGSEEANGGTPQSRISRET---RLPPI 308
W K W + SI E+ N + + T RLPP+
Sbjct: 190 -------WLKTWALTTAVSI-PEQDNIACTSPHVLKGTPLSRLPPL 227
Score = 31.6 bits (70), Expect = 3.4
Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 16/96 (16%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+K LDLS+NLIS S L AL++L + +N + + R +FR+
Sbjct: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP--------------RDAFRS- 144
Query: 147 FPLLKVLILQRNKLSDTPKGLW-KLKSLQSLDLSFN 181
L+ L L N+L +G + L +L L ++ N
Sbjct: 145 LRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 64.3 bits (155), Expect = 5e-10
Identities = 53/166 (31%), Positives = 78/166 (46%), Gaps = 17/166 (10%)
Query: 148 PLLKVLILQRNKLSDTPKG-LWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNK 206
PLL+ L L N++ G L L L+SLDLS N I WSD HN L+ L + SN+
Sbjct: 74 PLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNE 133
Query: 207 IFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL-EFPHLVVDLADNNWQCDDSVAVF 265
+ IP AF+ L+ L+ + L++N L T+ L HL ++ +N + C +
Sbjct: 134 LTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQIN--ENPFDCTCGIV-- 189
Query: 266 QNFISESWRKKWNVICNRSIGSEEANGGTPQSRISRET---RLPPI 308
W K W + SI E+ N + + T RLPP+
Sbjct: 190 -------WLKTWALTTAVSI-PEQDNIACTSPHVLKGTPLSRLPPL 227
Score = 31.6 bits (70), Expect = 3.4
Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 16/96 (16%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+K LDLS+NLIS S L AL++L + +N + + R +FR+
Sbjct: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIP--------------RDAFRS- 144
Query: 147 FPLLKVLILQRNKLSDTPKGLW-KLKSLQSLDLSFN 181
L+ L L N+L +G + L +L L ++ N
Sbjct: 145 LRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINEN 180
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 63.5 bits (153), Expect = 8e-10
Identities = 69/246 (28%), Positives = 112/246 (45%), Gaps = 11/246 (4%)
Query: 1 MKNLYFRVITIVIGLYFTGIMTNASRKSNILFNSECQWNEYILTNCSFTGKCDIPVDISQ 60
M L F + + + L T + K + +S CQ NC G IP + +
Sbjct: 1 MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPE 60
Query: 61 TAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNA 120
+ + ++ N + +S + L L N+ I + F L L L L+NN
Sbjct: 61 STVFLYLTGNNISYINESELTGLH-SLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF 119
Query: 121 IHSLS----LDLLSPKSSWVKRHRSSFR-----NRFPLLKVLILQRNKLSDTPKGLWK-L 170
I L LL+ ++ +++ ++ SF N ++ L LQRN+L+ G + +
Sbjct: 120 IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGM 179
Query: 171 KSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNA 230
+L+ LDLS N IL+I S F + L L L SN + K+P AF+ LK L+ + LS+N
Sbjct: 180 VALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNP 239
Query: 231 LITILP 236
+ I P
Sbjct: 240 IEAIQP 245
Score = 32.0 bits (71), Expect = 2.6
Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 15/96 (15%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+KHL LS+N + + F+ L L L L N I S+ D +F N
Sbjct: 278 LKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDND--------------TFENM 323
Query: 147 FPLLKVLILQRNKLSDT-PKGLWKLKSLQSLDLSFN 181
LK+L L N L+ P+ L L SL L + N
Sbjct: 324 GASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 62.4 bits (150), Expect = 2e-09
Identities = 54/200 (27%), Positives = 92/200 (46%), Gaps = 25/200 (12%)
Query: 42 ILTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEW----KIKHLDLSNNLI 97
+ T C+ G +P +I + + ++ NF ++ K++++ + L LS N I
Sbjct: 33 LATLCAKKGLLFVPPNIDRRTVELRLADNFV-----TNIKRKDFANMTSLVDLTLSRNTI 87
Query: 98 SKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQR 157
S IT FA L L L+L++N + ++ D+ S S+ L LIL
Sbjct: 88 SFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSN---------------LHHLILNN 132
Query: 158 NKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFK 216
N+L+ + + +L+ LDLS+N + I W + L L L N I IP F
Sbjct: 133 NQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFS 192
Query: 217 DLKKLQVIDLSNNALITILP 236
L K+ +D+++N L + P
Sbjct: 193 HLHKMTRLDVTSNKLQKLPP 212
Score = 40.8 bits (94), Expect = 0.006
Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 1/103 (0%)
Query: 176 LDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITIL 235
L L+ N + I DF N L +L L N I I P AF DL+ L+ + L++N L I
Sbjct: 56 LRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKIT 115
Query: 236 PMMIIALEFPHLVVDLADNNWQCDDSVAVFQNFISESWRKKWN 278
M L H ++ L +N S A F E +N
Sbjct: 116 NDMFSGLSNLHHLI-LNNNQLTLISSTAFDDVFALEELDLSYN 157
Score = 31.6 bits (70), Expect = 3.4
Identities = 24/102 (23%), Positives = 44/102 (43%), Gaps = 1/102 (0%)
Query: 28 SNILFNSECQWNEYILTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKI 87
+N +F+ + IL N T D +D+S+N + +K +
Sbjct: 115 TNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMV-SL 173
Query: 88 KHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLL 129
L L +N+I I F++LH + L++++N + L D L
Sbjct: 174 HTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPL 215
>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
Length = 347
Score = 62.4 bits (150), Expect = 2e-09
Identities = 70/284 (24%), Positives = 123/284 (43%), Gaps = 41/284 (14%)
Query: 52 CDIPVDISQ--TAATVDVSFNFFRVL-LQSHTKKEEWKIKHLDLSNNLISKITLSPFAYL 108
C P +I A TV ++ FF + L ++ + K++ L LS+N + ++ +
Sbjct: 56 CQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPV 115
Query: 109 HALEVLNLSNNAIHSL---------SLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNK 159
L VL+L+ NA+ L +LD L K + ++ S+ + L L L N+
Sbjct: 116 PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNR 175
Query: 160 LSDTPKGLW-KLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI----------- 207
L P GL L++LDL N + + LQLE L L+ NK+
Sbjct: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
Query: 208 -------------FKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVV----D 250
++ AF+ L++L ++DLSNN+L ++ + +L P+ + D
Sbjct: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFD 295
Query: 251 LADNNWQCDDSVAVFQNFISESWRKKWNVICNRSIGSEEANGGT 294
++ N W CD +++ ++ K ++ R G E G T
Sbjct: 296 ISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQT 339
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 62.4 bits (150), Expect = 2e-09
Identities = 65/254 (25%), Positives = 102/254 (40%), Gaps = 65/254 (25%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSS------------ 134
+K L+L+ NL++++ F L +L+ L LSNNA+ L + S
Sbjct: 171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS 230
Query: 135 ----------------WVKRHRSSFRNRFPL--------LKVLILQRNKLSDTPKGLW-- 168
W++R+ + PL L L LQ N L P GL+
Sbjct: 231 ELPPQVFSQLFCLERLWLQRNAIT---HLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAH 287
Query: 169 -----------------------KLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
L +L+SL LS+N I + F + +L L L SN
Sbjct: 288 TPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSN 347
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAVF 265
+ + P F++L KL+++ LS N L T LP I + + L N WQCD +A
Sbjct: 348 NLTALHPALFQNLSKLELLSLSKNQL-TTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYL 406
Query: 266 QNFISESWRKKWNV 279
N++ + + N+
Sbjct: 407 FNWLQQYTDRLLNI 420
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/153 (33%), Positives = 74/153 (48%), Gaps = 17/153 (11%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
L L+ N++ + F +L ALE L+L N + +L L P +
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTH--------------- 170
Query: 150 LKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
LK L L +N L+ P+ L+ L SLQ+L LS N + + F L+ L L SN I
Sbjct: 171 LKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS 230
Query: 209 KIPPQAFKDLKKLQVIDLSNNALITILPMMIIA 241
++PPQ F L L+ + L NA IT LP+ I A
Sbjct: 231 ELPPQVFSQLFCLERLWLQRNA-ITHLPLSIFA 262
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 61.2 bits (147), Expect = 4e-09
Identities = 57/209 (27%), Positives = 90/209 (43%), Gaps = 26/209 (12%)
Query: 39 NEYILTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWK----IKHLDLSN 94
+E + T C G +P DI + + + NF H ++++ + L LS
Sbjct: 31 SESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFI-----IHISRQDFANMTGLVDLTLSR 85
Query: 95 NLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLI 154
N IS I F L +L L+L +N + SL D L + L+ LI
Sbjct: 86 NTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVN---------------LQHLI 130
Query: 155 LQRNKLSDTPKGLWK--LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPP 212
+ N+L ++ L +L+ LDLS+N + + W + L L L N + I
Sbjct: 131 VNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAE 190
Query: 213 QAFKDLKKLQVIDLSNNALITILPMMIIA 241
F DL+KL +DL++N L + P I A
Sbjct: 191 GTFADLQKLARLDLTSNRLQKLPPDPIFA 219
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/144 (32%), Positives = 69/144 (47%), Gaps = 16/144 (11%)
Query: 89 HLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFP 148
+LDLS N ++++ F +L LE L LS N + + S S
Sbjct: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS-------------- 115
Query: 149 LLKVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI 207
LK+L+LQ N+L P + LW+L SLQSL L N I + F L +L L N +
Sbjct: 116 -LKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174
Query: 208 FKIPPQAFKDLKKLQVIDLSNNAL 231
+IP +A +L LQ + L+ N +
Sbjct: 175 TEIPVRALNNLPALQAMTLALNRI 198
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/150 (30%), Positives = 73/150 (48%), Gaps = 11/150 (7%)
Query: 94 NNLISKITLSPFAYLHALEVLNLSNNAIH---------SLSLDLLSPKSSWVKRHRSSFR 144
+N I + S F YL L L+L N A+ + SL++L+ + ++ S
Sbjct: 290 DNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 348
Query: 145 NRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKS 204
+ P L+VL L N++ + P L + + L+ + L N I +IG F L+ L L
Sbjct: 349 QQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 407
Query: 205 NKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
N I I P+AF L L +DL++N L T+
Sbjct: 408 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 437
Score = 58.5 bits (140), Expect = 3e-08
Identities = 59/210 (28%), Positives = 97/210 (46%), Gaps = 18/210 (8%)
Query: 36 CQWNEYILT-NCSFTGKCDIPVDISQTAATVDVSFNFFRVL---LQSHTKKEEWKIKHLD 91
CQ + +L+ +CS G +P D+ A +D+S N L L H + ++ L
Sbjct: 41 CQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRF----LEELR 96
Query: 92 LSNNLISKITLSPFAYLHALEVLNLSNNAIHSL---------SLDLLSPKSSWVKRHRSS 142
LS N +S I F+ L++L++L L NN + + SL L ++ +
Sbjct: 97 LSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPER 156
Query: 143 FRNRFPLLKVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLC 201
L+ L L N L++ P + L L +LQ++ L+ N I I F N L L
Sbjct: 157 SFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLH 216
Query: 202 LKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
L +N+I + +F+ L L+ +DL+ N L
Sbjct: 217 LHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/178 (28%), Positives = 81/178 (45%), Gaps = 12/178 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLS--PKSSWVKRHRSSF 143
+++ L NN I I F L+ ++ +N I + PK + + +
Sbjct: 258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
Query: 144 RNRFPLLK------VLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQ 196
FP LK +L L R + P G+ + L L+ L+LS N I ++ H C +
Sbjct: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQK 375
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADN 254
LE + L+ N+I++I F L LQ +DLS NA+ +I P L + +DL DN
Sbjct: 376 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH-SLVKLDLTDN 432
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 60.8 bits (146), Expect = 5e-09
Identities = 63/222 (28%), Positives = 101/222 (45%), Gaps = 29/222 (13%)
Query: 55 PVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVL 114
P + +AA+VD R + + + E LDL N I++IT FA L L VL
Sbjct: 35 PTKCTCSAASVDCHGLGLRAVPRGIPRNAE----RLDLDRNNITRITKMDFAGLKNLRVL 90
Query: 115 NLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWK-LKSL 173
+L +N + + R +F++ L+ L L +NKL P+ L++ L
Sbjct: 91 HLEDNQVSVIE--------------RGAFQD-LKQLERLRLNKNKLQVLPELLFQSTPKL 135
Query: 174 QSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALIT 233
LDLS N I I F ++NL L +N I I AF+ L+ L+++ L+NN +
Sbjct: 136 TRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISR 195
Query: 234 ILPMMIIALEFPHL----VVDLADNNWQCDDSVAVFQNFISE 271
IL F H+ + L N+ CD +A +++ +
Sbjct: 196 IL-----VTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQ 232
Score = 51.2 bits (121), Expect = 4e-06
Identities = 38/128 (29%), Positives = 65/128 (50%), Gaps = 2/128 (1%)
Query: 146 RFPLLKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKS 204
++ LK + + +N++SD P LKSL SL L N I +I F + L+ L L +
Sbjct: 329 QYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNA 388
Query: 205 NKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAV 264
NKI + F+DL+ L ++ L +N L TI + L+ + LA N + CD +
Sbjct: 389 NKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ-TLHLAQNPFVCDCHLKW 447
Query: 265 FQNFISES 272
+++ ++
Sbjct: 448 LADYLQDN 455
Score = 47.8 bits (112), Expect = 5e-05
Identities = 37/131 (28%), Positives = 58/131 (44%), Gaps = 3/131 (2%)
Query: 153 LILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPP 212
L L+ N L+ P+ L L+ L +DLS N I + F N L L L N++ IP
Sbjct: 757 LYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPV 816
Query: 213 QAFKDLKKLQVIDLSNNALITILPMMIIAL-EFPHLVVDLADNNWQCDDSVAVFQNFISE 271
AF L+ L+V+ L N + ++ L HL L N CD S+ ++
Sbjct: 817 HAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLA--LGTNPLHCDCSLRWLSEWVKA 874
Query: 272 SWRKKWNVICN 282
+++ C+
Sbjct: 875 GYKEPGIARCS 885
Score = 41.6 bits (96), Expect = 0.003
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 11/149 (7%)
Query: 43 LTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITL 102
+ +C G +IP ++ + + + N + + + + K+K +D+S N IS I
Sbjct: 290 IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYK-KLKRIDISKNQISDIAP 348
Query: 103 SPFAYLHALEVLNLSNNAIHSL---------SLDLLSPKSSWVKRHRSSFRNRFPLLKVL 153
F L +L L L N I + SL LL ++ + R + L +L
Sbjct: 349 DAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLL 408
Query: 154 ILQRNKLSDTPKGLW-KLKSLQSLDLSFN 181
L NKL KGL+ L+S+Q+L L+ N
Sbjct: 409 SLYDNKLQTISKGLFAPLQSIQTLHLAQN 437
Score = 35.0 bits (79), Expect = 0.31
Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 50/195 (25%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLS--PK------------ 132
+K+L L NN IS I F L LE+L L+NN I + + + PK
Sbjct: 159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY 218
Query: 133 --------SSWVKRHRSSFRNRFPLLKVLILQRN-KLSDTPKGLWKLKSLQS-------- 175
S W+++ R+ +F L + R ++D K + + S
Sbjct: 219 CDCHLAWLSDWLRQRRTV--GQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNAN 276
Query: 176 --------------LDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKL 221
+D G+++I + +++ L+ N I IP AF KKL
Sbjct: 277 SISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIR---LEQNSIKAIPAGAFTQYKKL 333
Query: 222 QVIDLSNNALITILP 236
+ ID+S N + I P
Sbjct: 334 KRIDISKNQISDIAP 348
Score = 33.9 bits (76), Expect = 0.68
Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 16/93 (17%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
+DLSNN IS +T F+ + L L LS N + + + N
Sbjct: 780 IDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAF---------------NGLRS 824
Query: 150 LKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFN 181
L+VL L N +S P+G + L SL L L N
Sbjct: 825 LRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 60.8 bits (146), Expect = 5e-09
Identities = 54/156 (34%), Positives = 75/156 (48%), Gaps = 11/156 (7%)
Query: 143 FRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCL 202
F RF L VL L RN +S+ P G+ L LQ L LS+N I + + NC LE L L
Sbjct: 101 FIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVP-KELSNCASLEKLEL 159
Query: 203 KSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMII---ALEFPHLVVDLADNNW-QC 258
N+ PQ +L KL +DLS N TI P+ ++ ALE+ +D+ N Q
Sbjct: 160 AVNRDICDLPQELSNLLKLTHLDLSMNDFTTI-PLAVLNMPALEW----LDMGSNKLEQL 214
Query: 259 DDSVAVFQNFISESWRKKWNVICNRSIGSEEANGGT 294
D++ QN + W ++ + C S N GT
Sbjct: 215 PDTIERMQN-LHTLWLQRNEITCLPQTISNMKNLGT 249
Score = 37.4 bits (85), Expect = 0.062
Identities = 47/164 (28%), Positives = 65/164 (39%), Gaps = 39/164 (23%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
LDLS N IS+I L L+ L LS N I ++ +L + S L
Sbjct: 111 LDLSRNTISEIPPG-IGLLTRLQELILSYNKIKTVPKELSNCAS---------------L 154
Query: 150 LKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
K+ + + D P+ L L L LDLS N I + N LE L + SNK+ +
Sbjct: 155 EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVL-NMPALEWLDMGSNKLEQ 213
Query: 210 IP----------------------PQAFKDLKKLQVIDLSNNAL 231
+P PQ ++K L + LSNN L
Sbjct: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKL 257
Score = 32.7 bits (73), Expect = 1.5
Identities = 32/110 (29%), Positives = 53/110 (48%), Gaps = 22/110 (20%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLH--ALEVLNLSNNAIHSLSLDLLSPKSS----WVKRH 139
K+ HLDLS N T P A L+ ALE L++ +N + L D + + W++R+
Sbjct: 177 KLTHLDLSMN---DFTTIPLAVLNMPALEWLDMGSNKLEQLP-DTIERMQNLHTLWLQRN 232
Query: 140 R--------SSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFN 181
S+ +N L L+L NKL D P + ++ +L+ ++ N
Sbjct: 233 EITCLPQTISNMKN----LGTLVLSNNKLQDIPVCMEEMANLRFVNFRDN 278
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 60.5 bits (145), Expect = 7e-09
Identities = 64/222 (28%), Positives = 99/222 (44%), Gaps = 29/222 (13%)
Query: 55 PVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVL 114
P S + +TVD + L+S + + LDL+ N I++IT + FA L L VL
Sbjct: 29 PAQCSCSGSTVDCH----GLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVL 84
Query: 115 NLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWK-LKSL 173
L N I ++ R +F++ L+ L L RN L P+ L+ L
Sbjct: 85 QLMENKISTIE--------------RGAFQD-LKELERLRLNRNHLQLFPELLFLGTAKL 129
Query: 174 QSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALIT 233
LDLS N I I F + ++NL L N+I I AF+ L+ L+V+ L+NN +
Sbjct: 130 YRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNI-- 187
Query: 234 ILPMMIIALEFPHL----VVDLADNNWQCDDSVAVFQNFISE 271
+ F H+ L NN CD +A +++ +
Sbjct: 188 ---TRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQ 226
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/84 (36%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 153 LILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPP 212
L L N+ + PK L K L +DLS N I + F N QL L L N++ IPP
Sbjct: 759 LYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPP 818
Query: 213 QAFKDLKKLQVIDLSNNALITILP 236
+ F LK L+++ L N I+++P
Sbjct: 819 RTFDGLKSLRLLSLHGND-ISVVP 841
Score = 47.0 bits (110), Expect = 8e-05
Identities = 46/191 (24%), Positives = 77/191 (40%), Gaps = 41/191 (21%)
Query: 43 LTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITL 102
+ +C G +IP ++ +T + + N +V+ + K++ +DLSNN IS++
Sbjct: 283 IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYK-KLRRIDLSNNQISELAP 341
Query: 103 SPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSD 162
F L +L L +L NK+++
Sbjct: 342 DAFQGLRSLNSL---------------------------------------VLYGNKITE 362
Query: 163 TPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKL 221
PK L++ L SLQ L L+ N I + F + L L L NK+ I F L+ +
Sbjct: 363 LPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAI 422
Query: 222 QVIDLSNNALI 232
Q + L+ N I
Sbjct: 423 QTMHLAQNPFI 433
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 2/111 (1%)
Query: 150 LKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
L+ + L N++S+ P L+SL SL L N I ++ S F L+ L L +NKI
Sbjct: 326 LRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKIN 385
Query: 209 KIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCD 259
+ AF+DL L ++ L +N L TI L + LA N + CD
Sbjct: 386 CLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQ-TMHLAQNPFICD 435
Score = 35.8 bits (81), Expect = 0.18
Identities = 18/35 (51%), Positives = 22/35 (62%)
Query: 202 LKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILP 236
L+ N I IPP AF KKL+ IDLSNN + + P
Sbjct: 307 LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAP 341
Score = 34.3 bits (77), Expect = 0.52
Identities = 36/123 (29%), Positives = 54/123 (43%), Gaps = 17/123 (13%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
+ L L N + + Y H L +++LSNN I +LS SF N
Sbjct: 756 VTELYLDGNQFTLVPKELSNYKH-LTLIDLSNNRISTLS--------------NQSFSNM 800
Query: 147 FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
LL LIL N+L P + LKSL+ L L N I + F++ L +L + +N
Sbjct: 801 TQLL-TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Query: 206 KIF 208
++
Sbjct: 860 PLY 862
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 60.1 bits (144), Expect = 9e-09
Identities = 54/168 (32%), Positives = 86/168 (51%), Gaps = 21/168 (12%)
Query: 85 WKI---KHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSS--WVKRH 139
WK+ ++LDLS+N +S++ P +L +L+L NAI S+ ++L+P S ++ H
Sbjct: 333 WKLSSLEYLDLSSNNLSRV---PAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLH 389
Query: 140 RSSFRNR--FPL-------LKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSD 190
+ R + PL L + L N L P GL + +++L + N I IG D
Sbjct: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGL--PRRVRTLMILHNQITGIGRED 447
Query: 191 FHNCLQLENLCLKSNKIF--KIPPQAFKDLKKLQVIDLSNNALITILP 236
F LE L L N+I ++ AF+ L+ L+ +DLS N L T+ P
Sbjct: 448 FATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP 495
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 17/164 (10%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRN 145
+++ L + +N I+ I FA + LE LNLS N I S + HR +FR
Sbjct: 429 RVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQV------------HRDAFR- 475
Query: 146 RFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
+ LL+ L L N+L P GL +++ L + N + + QL L L SN
Sbjct: 476 KLRLLRSLDLSGNRLHTLPPGL--PRNVHVLKVKRNELAALARGALVGMAQLRELYLTSN 533
Query: 206 KIFK--IPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL 247
++ + P+A+ DL LQ++D++ N L I + +LE+ +L
Sbjct: 534 RLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYL 577
Score = 53.5 bits (127), Expect = 8e-07
Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 38/178 (21%)
Query: 89 HLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLD------LLSPKSSWVKRHRSS 142
HL L NN + KI + LH LE LNL NN + S L L + ++ ++ +
Sbjct: 148 HLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLT 207
Query: 143 FRNRF--------------------------PLLKVLILQRNKLSDT--PKGLWKLKS-L 173
RF P L+ + L NKL+D P ++ S +
Sbjct: 208 LAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNV 267
Query: 174 QSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
+ L LS N + + H L L LK+NK+ KIPP AF +L L+ + L NN L
Sbjct: 268 EVLILSSNFLRHV---PKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Score = 53.1 bits (126), Expect = 1e-06
Identities = 53/162 (32%), Positives = 72/162 (44%), Gaps = 20/162 (12%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
L L NN + KI F+ L +L L L NN + LD ++ W +
Sbjct: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLD---NETFW----------KLSS 337
Query: 150 LKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
L+ L L N LS P GL +SL L L N I + + LE L L SN++ +
Sbjct: 338 LEYLDLSSNNLSRVPAGL--PRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE 395
Query: 210 --IPPQAFKDLKKLQVIDLSNNALITI---LPMMIIALEFPH 246
I P AF+ LK+L + L NNAL + LP + L H
Sbjct: 396 QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH 437
Score = 40.8 bits (94), Expect = 0.006
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 18/156 (11%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
++ LDLS N + + P + VL + N + +L+ L + + + +S R R
Sbjct: 480 LRSLDLSGNRLHTL---PPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLR 536
Query: 147 -----------FPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCL 195
L++L + N+L++ P+GL +SL+ L L N I + + F +
Sbjct: 537 SRALGPRAWVDLAHLQLLDIAGNQLTEIPEGL--PESLEYLYLQNNKISAVPANAFDSTP 594
Query: 196 QLENLCLKSNKIF--KIPPQAFKDLKKLQVIDLSNN 229
L+ + L+ NK+ + AF+ LK LQV+D+ N
Sbjct: 595 NLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 59.7 bits (143), Expect = 1e-08
Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 14/159 (8%)
Query: 76 LQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSW 135
LQ+ K + L+L+ N I++I + FA L L VL L N I ++
Sbjct: 52 LQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKE- 110
Query: 136 VKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCL 195
++R R + RN+ +L L+ Q N+ +L LDLS N I I F
Sbjct: 111 LERLRLN-RNQLHMLPELLFQNNQ------------ALSRLDLSENAIQAIPRKAFRGAT 157
Query: 196 QLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
L+NL L N+I I AF+ L+ L+V+ L+NN + TI
Sbjct: 158 DLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTI 196
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/82 (37%), Positives = 43/82 (52%)
Query: 153 LILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPP 212
L L N+ + P L K LQ +DLS N I + S F N QL L L N + IPP
Sbjct: 766 LYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPP 825
Query: 213 QAFKDLKKLQVIDLSNNALITI 234
AF+ L+ L+++ L N + T+
Sbjct: 826 LAFQGLRSLRLLSLHGNDISTL 847
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 2/121 (1%)
Query: 150 LKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
L+ + L N++++ P L+SL SL L N I + F L+ L L +NKI
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 209 KIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAVFQNF 268
I P AF+DL+ L ++ L +N + ++ +L + LA N + CD ++ +F
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ-TLHLAQNPFICDCNLKWLADF 453
Query: 269 I 269
+
Sbjct: 454 L 454
Score = 44.3 bits (103), Expect = 5e-04
Identities = 45/191 (23%), Positives = 74/191 (38%), Gaps = 41/191 (21%)
Query: 43 LTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITL 102
+ +C G IP ++ +T + + N + + K++ +DLSNN I++I
Sbjct: 292 IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYR-KLRRIDLSNNQIAEIAP 350
Query: 103 SPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSD 162
F L +L L+L NK++D
Sbjct: 351 DAFQGLRSL---------------------------------------NSLVLYGNKITD 371
Query: 163 TPKGLW-KLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKL 221
P+G++ L +LQ L L+ N I I F + L L L NKI + F L+ +
Sbjct: 372 LPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAI 431
Query: 222 QVIDLSNNALI 232
Q + L+ N I
Sbjct: 432 QTLHLAQNPFI 442
Score = 39.7 bits (91), Expect = 0.012
Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 155 LQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQ 213
L+ N + P G + + L+ +DLS N I +I F L +L L NKI +P
Sbjct: 316 LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRG 375
Query: 214 AFKDLKKLQVIDLSNNALITILP 236
F L LQ++ L+ N + I P
Sbjct: 376 VFGGLYTLQLLLLNANKINCIRP 398
Score = 33.9 bits (76), Expect = 0.68
Identities = 35/108 (32%), Positives = 50/108 (46%), Gaps = 19/108 (17%)
Query: 102 LSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLS 161
LS F YL ++++LSNN I SLS SSF N L LIL N L
Sbjct: 780 LSTFKYL---QLVDLSNNKISSLS--------------NSSFTN-MSQLTTLILSYNALQ 821
Query: 162 DTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
P ++ L+SL+ L L N I + F + L +L + +N ++
Sbjct: 822 CIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLY 869
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 1/66 (1%)
Query: 171 KSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNA 230
+++ + L NGI I F +L + L +N+I +I P AF+ L+ L + L N
Sbjct: 309 ETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNK 368
Query: 231 LITILP 236
IT LP
Sbjct: 369 -ITDLP 373
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 16/143 (11%)
Query: 90 LDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPL 149
L L +N I+++ FA L L+L +N I ++ D +F+ + L
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKED--------------AFQGLYKL 111
Query: 150 LKVLILQRNKLSDTPKGLW-KLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIF 208
K LIL NK+ P + +L +LQ+LDLSFN + + F+ +L+ L L+SN +
Sbjct: 112 -KELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLR 170
Query: 209 KIPPQAFKDLKKLQVIDLSNNAL 231
IP + F D + L+ +DLS N L
Sbjct: 171 TIPVRLFWDCRSLEFLDLSTNRL 193
Score = 52.4 bits (124), Expect = 2e-06
Identities = 53/208 (25%), Positives = 100/208 (48%), Gaps = 14/208 (6%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSW------VKRHR 140
+++LDLS N +S + F L L+ L+L +N++ ++ + L S R R
Sbjct: 135 LQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLR 194
Query: 141 SSFRNRFP---LLKVLILQRNKLSDTPKGLW-KLKSLQSLDLSFNGILQIGWSDFHNCLQ 196
S RN F L+ L L+ N+L+ + +L SL +L L +N I +
Sbjct: 195 SLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGT 254
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNW 256
LE L L N+I I F+ + L+++ + NN L ++ ++ +L V L+ N W
Sbjct: 255 LEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLR-SLTTVGLSGNLW 313
Query: 257 QCDDSVAVFQNFISESWRKKW--NVICN 282
+C + +++ S++ +W +++C+
Sbjct: 314 ECSARICALASWLG-SFQGRWEHSILCH 340
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/154 (27%), Positives = 75/154 (48%), Gaps = 10/154 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLD----LLSPKSSWVKRHRS 141
K++ L L +N + I + F +LE L+LS N + SL+ + L+ + ++ ++
Sbjct: 158 KLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQL 217
Query: 142 SFRN-----RFPLLKVLILQRNKLSDTPKGL-WKLKSLQSLDLSFNGILQIGWSDFHNCL 195
+ N R L L LQ NK+S+ G+ W +L+ LDL+ N I I + F
Sbjct: 218 TKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMP 277
Query: 196 QLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNN 229
L+ L + +NK+ + + L+ L + LS N
Sbjct: 278 NLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGN 311
Score = 48.9 bits (115), Expect = 2e-05
Identities = 48/161 (29%), Positives = 72/161 (44%), Gaps = 21/161 (13%)
Query: 77 QSHTKKEE-----WKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSP 131
Q T KE+ +K+K L LS+N I + + F L L+ L+LS N + SL +L
Sbjct: 96 QISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYG 155
Query: 132 KSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGL-WKLKSLQSLDLSFNGILQIGWSD 190
L+ L L+ N L P L W +SL+ LDLS N + + +
Sbjct: 156 LRK---------------LQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNG 200
Query: 191 FHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
F ++L L L+ N++ KI F L L + L N +
Sbjct: 201 FAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKI 241
Score = 48.5 bits (114), Expect = 3e-05
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 8/120 (6%)
Query: 119 NAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLS----DTPKGLWKLKSLQ 174
NA SL L + + R F + F L L L N++S D +GL+KLK L
Sbjct: 57 NATDKGSLGLSLRHNHITELERDQFAS-FSQLTWLHLDHNQISTVKEDAFQGLYKLKELI 115
Query: 175 SLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
LS N I + + F + L+NL L N++ + P+ F L+KLQ + L +N+L TI
Sbjct: 116 ---LSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI 172
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
Query: 153 LILQRNKLSDTPKGLW-KLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIP 211
L L+ N +++ + + L L L N I + F +L+ L L SNKIF +P
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 212 PQAFKDLKKLQVIDLSNNALITILPMMIIAL 242
F L LQ +DLS N L ++ P + L
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGL 156
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/142 (32%), Positives = 67/142 (47%), Gaps = 16/142 (11%)
Query: 91 DLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLL 150
DLS N ++++ F +L LE L LS N + + S S L
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS---------------L 64
Query: 151 KVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
K+L+LQ N+L P + LW+L SLQSL L N I + F L +L L N + +
Sbjct: 65 KILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE 124
Query: 210 IPPQAFKDLKKLQVIDLSNNAL 231
IP +A +L LQ + L+ N +
Sbjct: 125 IPVRALNNLPALQAMTLALNRI 146
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/150 (30%), Positives = 73/150 (48%), Gaps = 11/150 (7%)
Query: 94 NNLISKITLSPFAYLHALEVLNLSNNAIH---------SLSLDLLSPKSSWVKRHRSSFR 144
+N I + S F YL L L+L N A+ + SL++L+ + ++ S
Sbjct: 238 DNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
Query: 145 NRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKS 204
+ P L+VL L N++ + P L + + L+ + L N I +IG F L+ L L
Sbjct: 297 QQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 355
Query: 205 NKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
N I I P+AF L L +DL++N L T+
Sbjct: 356 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 385
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/178 (28%), Positives = 81/178 (45%), Gaps = 12/178 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLS--PKSSWVKRHRSSF 143
+++ L NN I I F L+ ++ +N I + PK + + +
Sbjct: 206 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 265
Query: 144 RNRFPLLK------VLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQ 196
FP LK +L L R + P G+ + L L+ L+LS N I ++ H C +
Sbjct: 266 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQK 323
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADN 254
LE + L+ N+I++I F L LQ +DLS NA+ +I P L + +DL DN
Sbjct: 324 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH-SLVKLDLTDN 380
Score = 50.1 bits (118), Expect = 9e-06
Identities = 44/155 (28%), Positives = 73/155 (47%), Gaps = 10/155 (6%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL---------SLDLLSPKSSWVK 137
++ L LS N +S I F+ L++L++L L NN + + SL L ++ +
Sbjct: 40 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 99
Query: 138 RHRSSFRNRFPLLKVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQ 196
L+ L L N L++ P + L L +LQ++ L+ N I I F N
Sbjct: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
L L L +N+I + +F+ L L+ +DL+ N L
Sbjct: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/59 (37%), Positives = 32/59 (54%)
Query: 173 LQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
+ + DLS N + ++ FH+ LE L L N + IP QAF L L+++ L NN L
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/150 (30%), Positives = 73/150 (48%), Gaps = 11/150 (7%)
Query: 94 NNLISKITLSPFAYLHALEVLNLSNNAIH---------SLSLDLLSPKSSWVKRHRSSFR 144
+N I + S F YL L L+L N A+ + SL++L+ + ++ S
Sbjct: 151 DNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
Query: 145 NRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKS 204
+ P L+VL L N++ + P L + + L+ + L N I +IG F L+ L L
Sbjct: 210 QQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 268
Query: 205 NKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
N I I P+AF L L +DL++N L T+
Sbjct: 269 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 298
Score = 55.5 bits (132), Expect = 2e-07
Identities = 45/142 (31%), Positives = 68/142 (47%), Gaps = 17/142 (11%)
Query: 91 DLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLL 150
DLS N ++++ F +L LE L LS N + + S S L
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS---------------L 73
Query: 151 KVLILQRNKLSDTP-KGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK 209
K+L+LQ N+L P + LW+L SLQSLDL++N + + + +L+ L +N I
Sbjct: 74 KILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVA-IRTLGRLQELGFHNNNIKA 132
Query: 210 IPPQAFKDLKKLQVIDLSNNAL 231
IP +AF LQ I +N +
Sbjct: 133 IPEKAFMGNPLLQTIHFYDNPI 154
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/178 (28%), Positives = 81/178 (45%), Gaps = 12/178 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLS--PKSSWVKRHRSSF 143
+++ L NN I I F L+ ++ +N I + PK + + +
Sbjct: 119 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 178
Query: 144 RNRFPLLK------VLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQ 196
FP LK +L L R + P G+ + L L+ L+LS N I ++ H C +
Sbjct: 179 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQK 236
Query: 197 LENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADN 254
LE + L+ N+I++I F L LQ +DLS NA+ +I P L + +DL DN
Sbjct: 237 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH-SLVKLDLTDN 293
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 58.5 bits (140), Expect = 3e-08
Identities = 52/165 (31%), Positives = 79/165 (47%), Gaps = 16/165 (9%)
Query: 75 LLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSS 134
L+ H + + LDL N I +I S F L L L L+NN I +S
Sbjct: 40 LMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKIS--------- 90
Query: 135 WVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHN 193
R++F LL L L +N++ K +K L SL+ L + FN + + F +
Sbjct: 91 -----RNAFEGLENLL-YLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGD 144
Query: 194 CLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMM 238
L+LE L L +NK+ KIP +F +L L+ + L +NAL+ +M
Sbjct: 145 LLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLM 189
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/193 (25%), Positives = 81/193 (41%), Gaps = 18/193 (9%)
Query: 46 CSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPF 105
C+ TG +P I + + ++ NF + + + HL LS N I ++ F
Sbjct: 51 CAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMT-SLVHLTLSRNTIGQVAAGAF 109
Query: 106 AYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPK 165
A L AL L+L +N + + D L + L+ LIL N++
Sbjct: 110 ADLRALRALHLDSNRLAEVRGDQLRGLGN---------------LRHLILGNNQIRRVES 154
Query: 166 GLWK--LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQV 223
+ L +++ LDLS+N + + W + L L L N I I F L KL
Sbjct: 155 AAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVR 214
Query: 224 IDLSNNALITILP 236
+D+++N L + P
Sbjct: 215 LDMTSNRLHKLPP 227
Score = 31.2 bits (69), Expect = 4.4
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 61 TAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNA 120
T +D+S+N L + + L L +NLI I F LH L L++++N
Sbjct: 163 TVEDLDLSYNNLEAL-PWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNR 221
Query: 121 IHSLSLDLLSPKS 133
+H L D L +S
Sbjct: 222 LHKLPPDGLFLRS 234
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 57.4 bits (137), Expect = 6e-08
Identities = 51/158 (32%), Positives = 74/158 (46%), Gaps = 12/158 (7%)
Query: 89 HLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLS----------LDLLSPKSSWVKR 138
HL L N + + L FA+ AL L LSNN + L DL +S
Sbjct: 164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223
Query: 139 HRSSFRNRFPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQL 197
++FR L+ L+L N+L+ L+ L L+ LDLS N + I + F +L
Sbjct: 224 PDAAFRG-LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRL 282
Query: 198 ENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITIL 235
+ L L N I + P AF LK L+ +DLS+N + +L
Sbjct: 283 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 320
Score = 52.8 bits (125), Expect = 1e-06
Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 10/161 (6%)
Query: 92 LSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRH--RSSFRN---- 145
L N +S + + F L +L LNL + SL L + H R+ R+
Sbjct: 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 146 ---RFPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLC 201
P L L L N+LS GL++ L SL L+L +N + + + F L L
Sbjct: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 238
Query: 202 LKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL 242
L N++ + P F L +L+ +DLS NAL I + + L
Sbjct: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 279
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 16/146 (10%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
++ L L+ N ++ + + F+ L L L+LS NA+ ++ ++ +
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV---------------Q 278
Query: 147 FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
P L+ L L RN ++ G + LK+L+ LDLS N + + F L L L L N
Sbjct: 279 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNAL 231
I + P+ FKDL L+ + L +N +
Sbjct: 339 AIASLRPRTFKDLHFLEELQLGHNRI 364
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/168 (27%), Positives = 75/168 (44%), Gaps = 17/168 (10%)
Query: 65 VDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL 124
+D+S N R + +++ + +++ L L NLI+ + F L AL L+LS+N + L
Sbjct: 261 LDLSRNALRAI-KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 319
Query: 125 SLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGI 183
D L+VL L N ++ P+ L L+ L L N I
Sbjct: 320 LEDTFPGLLG---------------LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 364
Query: 184 LQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
Q+ F QLE L L N++ ++ AF L + V++LS N L
Sbjct: 365 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/166 (27%), Positives = 76/166 (45%), Gaps = 11/166 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL---------SLDLLSPKSSWV 136
+++ L L +N + ++ F L + V+NLS N + +L L L + S +
Sbjct: 377 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 436
Query: 137 KRHRSSFRNRFPLLKVLILQRNKLSDTPK-GLWKLKSLQSLDLSFNGILQIGWSDFHNCL 195
R R L+ L L+ N L + LW L L LDL+ N + + F
Sbjct: 437 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 496
Query: 196 QLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIA 241
+LE L L N++ ++P A L++ +D+S+N L LP ++A
Sbjct: 497 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL-EALPNSLLA 541
Score = 31.2 bits (69), Expect = 4.4
Identities = 14/44 (31%), Positives = 24/44 (54%)
Query: 200 LCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALE 243
L L N + +PP AF++L L ++L L ++ P ++ LE
Sbjct: 117 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 160
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 57.4 bits (137), Expect = 6e-08
Identities = 51/158 (32%), Positives = 74/158 (46%), Gaps = 12/158 (7%)
Query: 89 HLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLS----------LDLLSPKSSWVKR 138
HL L N + + L FA+ AL L LSNN + L DL +S
Sbjct: 126 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
Query: 139 HRSSFRNRFPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQL 197
++FR L+ L+L N+L+ L+ L L+ LDLS N + I + F +L
Sbjct: 186 PDAAFRG-LGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRL 244
Query: 198 ENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITIL 235
+ L L N I + P AF LK L+ +DLS+N + +L
Sbjct: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282
Score = 52.8 bits (125), Expect = 1e-06
Identities = 47/161 (29%), Positives = 71/161 (44%), Gaps = 10/161 (6%)
Query: 92 LSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRH--RSSFRN---- 145
L N +S + + F L +L LNL + SL L + H R+ R+
Sbjct: 81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 146 ---RFPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLC 201
P L L L N+LS GL++ L SL L+L +N + + + F L L
Sbjct: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
Query: 202 LKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIAL 242
L N++ + P F L +L+ +DLS NAL I + + L
Sbjct: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 241
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/146 (28%), Positives = 70/146 (47%), Gaps = 16/146 (10%)
Query: 87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNR 146
++ L L+ N ++ + + F+ L L L+LS NA+ ++ ++ +
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV---------------Q 240
Query: 147 FPLLKVLILQRNKLSDTPKGLWK-LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSN 205
P L+ L L RN ++ G + LK+L+ LDLS N + + F L L L L N
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
Query: 206 KIFKIPPQAFKDLKKLQVIDLSNNAL 231
I + P+ FKDL L+ + L +N +
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRI 326
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/168 (27%), Positives = 75/168 (44%), Gaps = 17/168 (10%)
Query: 65 VDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL 124
+D+S N R + +++ + +++ L L NLI+ + F L AL L+LS+N + L
Sbjct: 223 LDLSRNALRAI-KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 281
Query: 125 SLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSD-TPKGLWKLKSLQSLDLSFNGI 183
D L+VL L N ++ P+ L L+ L L N I
Sbjct: 282 LEDTFPGLLG---------------LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRI 326
Query: 184 LQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNAL 231
Q+ F QLE L L N++ ++ AF L + V++LS N L
Sbjct: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/166 (27%), Positives = 76/166 (45%), Gaps = 11/166 (6%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL---------SLDLLSPKSSWV 136
+++ L L +N + ++ F L + V+NLS N + +L L L + S +
Sbjct: 339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 398
Query: 137 KRHRSSFRNRFPLLKVLILQRNKLSDTPK-GLWKLKSLQSLDLSFNGILQIGWSDFHNCL 195
R R L+ L L+ N L + LW L L LDL+ N + + F
Sbjct: 399 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 458
Query: 196 QLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIA 241
+LE L L N++ ++P A L++ +D+S+N L LP ++A
Sbjct: 459 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL-EALPNSLLA 503
Score = 31.2 bits (69), Expect = 4.4
Identities = 14/44 (31%), Positives = 24/44 (54%)
Query: 200 LCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITILPMMIIALE 243
L L N + +PP AF++L L ++L L ++ P ++ LE
Sbjct: 79 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLE 122
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 57.4 bits (137), Expect = 6e-08
Identities = 59/238 (24%), Positives = 94/238 (39%), Gaps = 65/238 (27%)
Query: 32 FNSECQWNEYILTNCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLD 91
F+ +C + + +CS G +P D+ T+ + N L S ++ LD
Sbjct: 41 FSCKCD-SRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSAL-PSWAFANLSSLQRLD 98
Query: 92 LSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLK 151
LSNN + ++ S F L L L L NN+I +L DLL RH PLL+
Sbjct: 99 LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLL--------RHS-------PLLR 143
Query: 152 VLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIP 211
LDLS NG+ Q+ F L L +L L+SN++ +
Sbjct: 144 -----------------------HLDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLD 180
Query: 212 PQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAVFQNFI 269
F+ L LQ++ + DN W+CD ++ F++++
Sbjct: 181 RLTFEPLANLQLL-------------------------QVGDNPWECDCNLREFKHWM 213
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 57.0 bits (136), Expect = 8e-08
Identities = 48/162 (29%), Positives = 78/162 (48%), Gaps = 17/162 (10%)
Query: 88 KHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRF 147
+HL L NN + ++ + + L L LNL NN I S L P ++
Sbjct: 75 QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGL----PDEAF---------ESL 121
Query: 148 PLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI 207
L+ L + NKLS P+ L +SL+ DL+ N +++I F L ++ L +N++
Sbjct: 122 TQLQHLCVAHNKLSVAPQFL--PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQL 179
Query: 208 FK--IPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL 247
+PP AF+ + + + LSNN L + P + +LE HL
Sbjct: 180 SNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHL 221
Score = 50.4 bits (119), Expect = 7e-06
Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 24/193 (12%)
Query: 59 SQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSN 118
S+ AT+ +S N L S ++ L L NNLISK+ + L L L +
Sbjct: 192 SEAIATLSLSNNQLSYLPPSLPPS----LERLHLQNNLISKVPRGALSRQTQLRELYLQH 247
Query: 119 NAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDL 178
N + LD +++ K H L+ L L N+L+ P GL ++L L L
Sbjct: 248 NQLTDSGLD----ATTFSKLHS---------LEYLDLSHNQLTTVPAGL--PRTLAILHL 292
Query: 179 SFNGILQIGWSDFHNCLQLENLCLKSNKIFK--IPPQAFKDLKKLQVIDLSNNALITI-- 234
N I Q+ + H L L L+ N++ +P A + L+ L + L N L +
Sbjct: 293 GRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPP 352
Query: 235 -LPMMIIALEFPH 246
LP + AL PH
Sbjct: 353 ALPRRLRALVLPH 365
Score = 40.4 bits (93), Expect = 0.007
Identities = 52/197 (26%), Positives = 92/197 (46%), Gaps = 36/197 (18%)
Query: 73 RVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL------SL 126
R L T+ E ++H L+++ + T F+ LH+LE L+LS+N + ++ +L
Sbjct: 231 RGALSRQTQLRELYLQHNQLTDSGLDATT---FSKLHSLEYLDLSHNQLTTVPAGLPRTL 287
Query: 127 DLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKL--SDTPKG-LWKLKSLQSLDLSFNG- 182
+L + +++ ++ + L+ L+LQ N+L S P G L L+ L +L L NG
Sbjct: 288 AILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGL 347
Query: 183 --------------------ILQIGWSDFHNCLQLENLCLKSNKIF--KIPPQAFKDLKK 220
+ +G D L L L N++ ++ +AF+ L+
Sbjct: 348 DRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRA 407
Query: 221 LQVIDLSNNALITILPM 237
L+ +DL+ N L T LPM
Sbjct: 408 LRSLDLAGNQL-TRLPM 423
Score = 35.8 bits (81), Expect = 0.18
Identities = 43/159 (27%), Positives = 64/159 (40%), Gaps = 17/159 (10%)
Query: 91 DLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLL 150
DL+ N + +I F AL + L NN + + L +FR +
Sbjct: 149 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLP------------PDAFRGS-EAI 195
Query: 151 KVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK- 209
L L N+LS P L SL+ L L N I ++ QL L L+ N++
Sbjct: 196 ATLSLSNNQLSYLPPSL--PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
Query: 210 -IPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL 247
+ F L L+ +DLS+N L T+ + L HL
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHL 292
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 57.0 bits (136), Expect = 8e-08
Identities = 48/162 (29%), Positives = 78/162 (48%), Gaps = 17/162 (10%)
Query: 88 KHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRF 147
+HL L NN + ++ + + L L LNL NN I S L P ++
Sbjct: 77 QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGL----PDEAF---------ESL 123
Query: 148 PLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI 207
L+ L + NKLS P+ L +SL+ DL+ N +++I F L ++ L +N++
Sbjct: 124 TQLQHLCVAHNKLSVAPQFL--PRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQL 181
Query: 208 FK--IPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL 247
+PP AF+ + + + LSNN L + P + +LE HL
Sbjct: 182 SNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHL 223
Score = 50.4 bits (119), Expect = 7e-06
Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 24/193 (12%)
Query: 59 SQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSN 118
S+ AT+ +S N L S ++ L L NNLISK+ + L L L +
Sbjct: 194 SEAIATLSLSNNQLSYLPPSLPPS----LERLHLQNNLISKVPRGALSRQTQLRELYLQH 249
Query: 119 NAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDL 178
N + LD +++ K H L+ L L N+L+ P GL ++L L L
Sbjct: 250 NQLTDSGLD----ATTFSKLHS---------LEYLDLSHNQLTTVPAGL--PRTLAILHL 294
Query: 179 SFNGILQIGWSDFHNCLQLENLCLKSNKIFK--IPPQAFKDLKKLQVIDLSNNALITI-- 234
N I Q+ + H L L L+ N++ +P A + L+ L + L N L +
Sbjct: 295 GRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPP 354
Query: 235 -LPMMIIALEFPH 246
LP + AL PH
Sbjct: 355 ALPRRLRALVLPH 367
Score = 40.4 bits (93), Expect = 0.007
Identities = 52/197 (26%), Positives = 92/197 (46%), Gaps = 36/197 (18%)
Query: 73 RVLLQSHTKKEEWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL------SL 126
R L T+ E ++H L+++ + T F+ LH+LE L+LS+N + ++ +L
Sbjct: 233 RGALSRQTQLRELYLQHNQLTDSGLDATT---FSKLHSLEYLDLSHNQLTTVPAGLPRTL 289
Query: 127 DLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKL--SDTPKG-LWKLKSLQSLDLSFNG- 182
+L + +++ ++ + L+ L+LQ N+L S P G L L+ L +L L NG
Sbjct: 290 AILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGL 349
Query: 183 --------------------ILQIGWSDFHNCLQLENLCLKSNKIF--KIPPQAFKDLKK 220
+ +G D L L L N++ ++ +AF+ L+
Sbjct: 350 DRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRA 409
Query: 221 LQVIDLSNNALITILPM 237
L+ +DL+ N L T LPM
Sbjct: 410 LRSLDLAGNQL-TRLPM 425
Score = 35.8 bits (81), Expect = 0.18
Identities = 43/159 (27%), Positives = 64/159 (40%), Gaps = 17/159 (10%)
Query: 91 DLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLL 150
DL+ N + +I F AL + L NN + + L +FR +
Sbjct: 151 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLP------------PDAFRGS-EAI 197
Query: 151 KVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFK- 209
L L N+LS P L SL+ L L N I ++ QL L L+ N++
Sbjct: 198 ATLSLSNNQLSYLPPSL--PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 255
Query: 210 -IPPQAFKDLKKLQVIDLSNNALITILPMMIIALEFPHL 247
+ F L L+ +DLS+N L T+ + L HL
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHL 294
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 57.0 bits (136), Expect = 8e-08
Identities = 58/221 (26%), Positives = 91/221 (41%), Gaps = 74/221 (33%)
Query: 50 GKCDIP--------VDISQTAATVDVSFNFFRVLLQS------------------HTKKE 83
GKC P +D+S TVD++ NF + +S H K+
Sbjct: 217 GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKD 276
Query: 84 ----------EWKIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLSLDLLSPKS 133
++HLDLS+ + + F L L+VLNL+ N I
Sbjct: 277 PDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI------------ 324
Query: 134 SWVKRHRSSFRNRFPLLKVLILQRNKLSDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHN 193
NK++D + + L +LQ L+LS+N + ++ S+F+
Sbjct: 325 ------------------------NKIAD--EAFYGLDNLQVLNLSYNLLGELYSSNFYG 358
Query: 194 CLQLENLCLKSNKIFKIPPQAFKDLKKLQVIDLSNNALITI 234
++ + L+ N I I Q FK L+KLQ +DL +NAL TI
Sbjct: 359 LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399
Score = 51.6 bits (122), Expect = 3e-06
Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 66/245 (26%)
Query: 86 KIKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSL-----------------SLDL 128
K+ ++DL N I+ I F +L L+ L+L +NA+ ++ +L
Sbjct: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 420
Query: 129 LSPKSSWVKRHRSSFRN--------RFPLLKVLILQRNKLS-----DTPKGLWKLKSLQS 175
++ ++ + + N R P L++LIL +N+ S TP + SL+
Sbjct: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPS---ENPSLEQ 477
Query: 176 LDLSFNGILQIGWSD------FHNCLQLENLCLKSNKIFKIPPQAFKDL----------- 218
L L N +LQ+ W F L+ L L N + +PP F L
Sbjct: 478 LFLGEN-MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536
Query: 219 -----------KKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAVFQN 267
L+++D+S N L+ P + ++L V+D+ N + C+ ++ F N
Sbjct: 537 RLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS----VLDITHNKFICECELSTFIN 592
Query: 268 FISES 272
+++ +
Sbjct: 593 WLNHT 597
Score = 30.0 bits (66), Expect = 9.8
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 170 LKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKI-FKIPPQAFKDLKKLQVIDLSN 228
L + + L LSFN I + S F QL+ L L S I +AF++L L+++DL +
Sbjct: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGS 104
Query: 229 NALITILP 236
+ + + P
Sbjct: 105 SKIYFLHP 112
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,480,920
Number of Sequences: 37866
Number of extensions: 1763435
Number of successful extensions: 5602
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 160
Number of HSP's that attempted gapping in prelim test: 4275
Number of HSP's gapped (non-prelim): 1016
length of query: 880
length of database: 18,247,518
effective HSP length: 111
effective length of query: 769
effective length of database: 14,044,392
effective search space: 10800137448
effective search space used: 10800137448
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.