Search of human proteins with 66347875

Search of human proteins with 66347875

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66347875 complement component 1, r subcomponent [Homo
sapiens]
         (705 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66347875 complement component 1, r subcomponent [Homo sapiens]    1501   0.0  
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   534   e-151
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   529   e-150
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   491   e-138
gi|4502495 complement component 1, s subcomponent precursor [Hom...   474   e-133
gi|41393602 complement component 1, s subcomponent precursor [Ho...   474   e-133
gi|7706083 complement component 1, r subcomponent-like precursor...   391   e-108
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   306   3e-83
gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]         182   1e-45
gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]       178   1e-44
gi|45580723 haptoglobin-related protein [Homo sapiens]                172   1e-42
gi|22547221 tolloid-like 1 [Homo sapiens]                             149   9e-36
gi|6912724 tolloid-like 2 [Homo sapiens]                              149   9e-36
gi|21264361 mannan-binding lectin serine protease 2 isoform 2 pr...   145   2e-34
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   142   8e-34
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         141   2e-33
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          139   7e-33
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           137   3e-32
gi|148806900 epidermis-specific serine protease-like protein [Ho...   132   1e-30
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         132   1e-30
gi|4503627 coagulation factor XI precursor [Homo sapiens]             129   9e-30
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   126   8e-29
gi|117956391 protease, serine, 33 [Homo sapiens]                      125   2e-28
gi|4506115 protein C [Homo sapiens]                                   124   4e-28
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   124   4e-28
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   124   4e-28
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   124   4e-28
gi|13994276 marapsin [Homo sapiens]                                   123   5e-28
gi|4506153 prostasin preproprotein [Homo sapiens]                     122   1e-27
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          122   1e-27

>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score = 1501 bits (3885), Expect = 0.0
 Identities = 705/705 (100%), Positives = 705/705 (100%)

Query: 1   MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF 60
           MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF
Sbjct: 1   MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF 60

Query: 61  QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF 120
           QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF
Sbjct: 61  QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF 120

Query: 121 SNEENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGY 180
           SNEENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGY
Sbjct: 121 SNEENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGY 180

Query: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
           ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF
Sbjct: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240

Query: 241 DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL 300
           DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL
Sbjct: 241 DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL 300

Query: 301 RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360
           RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD
Sbjct: 301 RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360

Query: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420
           DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR
Sbjct: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420

Query: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF 480
           ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF
Sbjct: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF 480

Query: 481 TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV 540
           TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV
Sbjct: 481 TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV 540

Query: 541 SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME 600
           SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME
Sbjct: 541 SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME 600

Query: 601 EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV 660
           EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV
Sbjct: 601 EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV 660

Query: 661 RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED 705
           RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
Sbjct: 661 RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED 705


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  534 bits (1375), Expect = e-151
 Identities = 283/733 (38%), Positives = 411/733 (56%), Gaps = 56/733 (7%)

Query: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64

Query: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124

Query: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174

Query: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234

Query: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294

Query: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351

Query: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420
           DGTW   +P CKI DC  P  L +G   ++T   + TYK+ I+Y C EPYYKM       
Sbjct: 352 DGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKM------L 405

Query: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQR-QRIIGGQKAKMGNFPWQV 479
            +  G+YTC+AQG+W N+  G  +P CLP CG+P   +    +RIIGG+ A+ G FPWQ 
Sbjct: 406 NNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQA 465

Query: 480 FTNIHGR---------GGGALLGDRWILTAAHTLYPKEHEAQ----SNASLDVFLGHTNV 526
              +            G GALL   WILTAAH L  +  +      S   + V+LG  +V
Sbjct: 466 LIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDV 525

Query: 527 EELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYD 586
            +     N    RV +HPD+      N+  DIAL++L+  V LGP+++P+CLP  +    
Sbjct: 526 RDKSGAVNSSAARVVLHPDF---NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEGP 582

Query: 587 L-GLMGYVSGFGVMEEKIAHD-------------LRFVRLPVANPQACENWLRGKNRMDV 632
              ++G V+G+G+    +  D             L++V+LPV     C+     ++    
Sbjct: 583 APHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRSGNYS 642

Query: 633 FSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWG----IGCSRGYGFYT 688
            ++NMFCAG+    +D C GDSGG F + D  + RWV  G+VSWG     G  + YG YT
Sbjct: 643 VTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYT 702

Query: 689 KVLNYVDWIKKEM 701
           KV NYVDW+ ++M
Sbjct: 703 KVSNYVDWVWEQM 715


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  529 bits (1362), Expect = e-150
 Identities = 286/688 (41%), Positives = 394/688 (57%), Gaps = 41/688 (5%)

Query: 22  PQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD 81
           P+ +FG + SP FP  Y N+ E    +T P GYR++L F  FDLE S  C YD+VK+S+ 
Sbjct: 23  PEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG 82

Query: 82  KKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAV 141
            K L   CGQ  +     PGK  F S G+ + +TF +D+SNE+  T     GF A+Y A 
Sbjct: 83  AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFT-----GFEAFYAAE 137

Query: 142 DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEA 201
           D+DEC      GE    P C H CHN++GG++CSCR GY L  ++ +C A CS +++T+ 
Sbjct: 138 DIDECQVAP--GEA---PTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQR 192

Query: 202 SGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANG 261
           SG +SS EYPR YP    C YSI +E G ++ L F+E FD++ H +  CPYD L+I  + 
Sbjct: 193 SGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDR 252

Query: 262 KNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTII 321
           +  G FCGK  P  ++T SN V + F TDESGD  GWK+ YT+    CP P        +
Sbjct: 253 EEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPN-GHV 311

Query: 322 QNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRN 381
             +Q +Y  +D F   C+ GY+L++G+  L SFTAVCQ DG+W R MP C I DCG P +
Sbjct: 312 SPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDD 371

Query: 382 LPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKG 441
           LP+G   Y T  GV TYKA IQY C E +Y M+          G Y C A G W + +  
Sbjct: 372 LPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKV-------NDGKYVCEADGFWTSSKGE 424

Query: 442 EKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAA 501
           + +P C PVCG  ++      RI GGQKAK G+FPWQV         GALL D W+LTAA
Sbjct: 425 KSLPVCEPVCG--LSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAA 482

Query: 502 HTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIR----RVSVHPDYRQDESYNFEGD 557
           H +Y ++H+A   ++LD+ +G      L +L  H  +     V +H  Y  D    F+ D
Sbjct: 483 HAVYEQKHDA---SALDIRMG-----TLKRLSPHYTQAWSEAVFIHEGYTHDA--GFDND 532

Query: 558 IALLELENSVTLGPNLLPICLP--DNDTFYDLGLMGYVSGFGVMEEK-IAHDLRFVRLPV 614
           IAL++L N V +  N+ PICLP  + ++F     +G  SG+G+ +   +A +L +V +P+
Sbjct: 533 IALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPI 592

Query: 615 ANPQAC-ENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGI 673
            + Q C   + +        + NM CAG  S  +D+C+GDSGG     D  T+RW   GI
Sbjct: 593 VDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGI 652

Query: 674 VSWG-IGCSRG--YGFYTKVLNYVDWIK 698
           VSWG + C     YG YTKV+NY+ WI+
Sbjct: 653 VSWGSMNCGEAGQYGVYTKVINYIPWIE 680


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  491 bits (1263), Expect = e-138
 Identities = 263/715 (36%), Positives = 395/715 (55%), Gaps = 44/715 (6%)

Query: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64

Query: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124

Query: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174

Query: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234

Query: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294

Query: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351

Query: 361 DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR 420
           DGTW   +P CKI DC  P  L +G   ++T   + TYK+ I+Y C EPYYKM       
Sbjct: 352 DGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKM------L 405

Query: 421 ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPW-QV 479
            +  G+YTC+AQG+W N+  G  +P CLPVCG P    +   RI  G+ A+ G  PW  +
Sbjct: 406 NNNTGIYTCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAM 465

Query: 480 FTNIHGRG--GGALLGDRWILTAAHTLYP---------KEHEAQSNASLDVFLG-HTNVE 527
            ++++G+   GG+LLG  WI+TAAH L+          ++ +  S +   + LG H  + 
Sbjct: 466 LSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLR 525

Query: 528 ELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDL 587
                 +  ++  ++HP Y   +   FE D+AL+EL  S  L   ++PICLP+       
Sbjct: 526 SDENEQHLGVKHTTLHPQY---DPNTFENDVALVELLESPVLNAFVMPICLPEGP--QQE 580

Query: 588 GLMGYVSGFG-VMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLK 646
           G M  VSG+G    ++    L  + +P+ +   C+       +    +++M CAG     
Sbjct: 581 GAMVIVSGWGKQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKK--VTRDMICAGEKEGG 638

Query: 647 QDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVLNYVDWIKK 699
           +DAC GDSGG     +    +W   G VSWG  C +   YG Y+ + +  DWI++
Sbjct: 639 KDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQR 693


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  474 bits (1219), Expect = e-133
 Identities = 268/696 (38%), Positives = 387/696 (55%), Gaps = 50/696 (7%)

Query: 25  LFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKS 84
           ++GE+ SP +P+ YP+  E +  I VP GY + L F   D+E SE C YD V+I +    
Sbjct: 19  MYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTE 78

Query: 85  LGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLD 144
            GR CGQ  S   + P  +EF    NK+ + F +DFSNEE  T     GF AYY A D++
Sbjct: 79  EGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFT-----GFAAYYVATDIN 133

Query: 145 ECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGY 204
           EC     +        C H C+N++GGYFCSC P Y L +D  +C   CS +++T   G 
Sbjct: 134 ECTDFVDV-------PCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGE 186

Query: 205 ISSLEYPRSYPPDLRCNYSIRVERGLTLHLKF-LEPFDIDDHQQVHCPYDQLQIYANGKN 263
           I+S  YP+ YP + RC Y IR+E+G  + +    E FD++         D L   A  + 
Sbjct: 187 IASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQ 246

Query: 264 IGEFCGK--QRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTII 321
            G +CG     P +++T SNA+D++F TD +G  +GWKLRY  + + CP+  T +  ++ 
Sbjct: 247 FGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPN--SVW 304

Query: 322 QNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRN 381
           +  + +Y FRD    TC  G++++EG     SF + CQ +G W  +  +C+  DCG P +
Sbjct: 305 EPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPES 364

Query: 382 LPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKG 441
           + NG      +     + + I+Y C EPYY M+   G      G Y C   G W NE  G
Sbjct: 365 IENGKVEDPES---TLFGSVIRYTCEEPYYYMENGGG------GEYHCAGNGSWVNEVLG 415

Query: 442 EKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAA 501
            ++P+C+PVCG P  P E++QRIIGG  A + NFPWQVF + +   GGAL+ + W+LTAA
Sbjct: 416 PELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFD-NPWAGGALINEYWVLTAA 474

Query: 502 HTLYPKEHEAQSNASLDVFLGHTNVE--ELMKLGNHPIRRVSVHPDYR----QDESYNFE 555
           H +       + N    +++G T+V+   L K        V +HP ++     +   NF+
Sbjct: 475 HVV-------EGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFD 527

Query: 556 GDIALLELENSVTLGPNLLPICLPDNDTFYDL--GLMGYVSGFGVMEEK-IAHDLRFVRL 612
            DIAL+ L++ V +GP + PICLP   + Y+L  G +G +SG+G  E++  A  L+  RL
Sbjct: 528 NDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARL 587

Query: 613 PVANPQACENWLRGKNRMD----VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPN-TDR 667
           PVA  + C+     K   D    VF+ NM CAG      D+C+GDSGG FAV+DPN   +
Sbjct: 588 PVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNDKTK 646

Query: 668 WVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEE 703
           + A G+VSWG  C   YG YT+V NYVDWI K M+E
Sbjct: 647 FYAAGLVSWGPQCGT-YGLYTRVKNYVDWIMKTMQE 681


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  474 bits (1219), Expect = e-133
 Identities = 268/696 (38%), Positives = 387/696 (55%), Gaps = 50/696 (7%)

Query: 25  LFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKS 84
           ++GE+ SP +P+ YP+  E +  I VP GY + L F   D+E SE C YD V+I +    
Sbjct: 19  MYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTE 78

Query: 85  LGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLD 144
            GR CGQ  S   + P  +EF    NK+ + F +DFSNEE  T     GF AYY A D++
Sbjct: 79  EGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFT-----GFAAYYVATDIN 133

Query: 145 ECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEASGY 204
           EC     +        C H C+N++GGYFCSC P Y L +D  +C   CS +++T   G 
Sbjct: 134 ECTDFVDV-------PCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGE 186

Query: 205 ISSLEYPRSYPPDLRCNYSIRVERGLTLHLKF-LEPFDIDDHQQVHCPYDQLQIYANGKN 263
           I+S  YP+ YP + RC Y IR+E+G  + +    E FD++         D L   A  + 
Sbjct: 187 IASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQ 246

Query: 264 IGEFCGK--QRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTII 321
            G +CG     P +++T SNA+D++F TD +G  +GWKLRY  + + CP+  T +  ++ 
Sbjct: 247 FGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPN--SVW 304

Query: 322 QNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRN 381
           +  + +Y FRD    TC  G++++EG     SF + CQ +G W  +  +C+  DCG P +
Sbjct: 305 EPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPES 364

Query: 382 LPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKG 441
           + NG      +     + + I+Y C EPYY M+   G      G Y C   G W NE  G
Sbjct: 365 IENGKVEDPES---TLFGSVIRYTCEEPYYYMENGGG------GEYHCAGNGSWVNEVLG 415

Query: 442 EKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAA 501
            ++P+C+PVCG P  P E++QRIIGG  A + NFPWQVF + +   GGAL+ + W+LTAA
Sbjct: 416 PELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFD-NPWAGGALINEYWVLTAA 474

Query: 502 HTLYPKEHEAQSNASLDVFLGHTNVE--ELMKLGNHPIRRVSVHPDYR----QDESYNFE 555
           H +       + N    +++G T+V+   L K        V +HP ++     +   NF+
Sbjct: 475 HVV-------EGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFD 527

Query: 556 GDIALLELENSVTLGPNLLPICLPDNDTFYDL--GLMGYVSGFGVMEEK-IAHDLRFVRL 612
            DIAL+ L++ V +GP + PICLP   + Y+L  G +G +SG+G  E++  A  L+  RL
Sbjct: 528 NDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARL 587

Query: 613 PVANPQACENWLRGKNRMD----VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPN-TDR 667
           PVA  + C+     K   D    VF+ NM CAG      D+C+GDSGG FAV+DPN   +
Sbjct: 588 PVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNDKTK 646

Query: 668 WVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEE 703
           + A G+VSWG  C   YG YT+V NYVDWI K M+E
Sbjct: 647 FYAAGLVSWGPQCGT-YGLYTRVKNYVDWIMKTMQE 681


>gi|7706083 complement component 1, r subcomponent-like precursor
           [Homo sapiens]
          Length = 487

 Score =  391 bits (1004), Expect = e-108
 Identities = 176/303 (58%), Positives = 226/303 (74%), Gaps = 9/303 (2%)

Query: 400 ARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVE 459
           A++Q +C EPYY+         +  G  TC   G WK+ Q GE++ +C+PVCG+PV P+ 
Sbjct: 189 AKVQNHCQEPYYQA--------AAAGALTCATPGTWKDRQDGEEVLQCMPVCGRPVTPIA 240

Query: 460 QRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEA-QSNASLD 518
           Q Q  +G  +AK+GNFPWQ FT+IHGRGGGALLGDRWILTAAHT+YPK+  + + N S++
Sbjct: 241 QNQTTLGSSRAKLGNFPWQAFTSIHGRGGGALLGDRWILTAAHTVYPKDSVSLRKNQSVN 300

Query: 519 VFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICL 578
           VFLGHT ++E++KLGNHP+ RV VHPDYRQ+ES+NF GDIALLEL++S+ LGPN+LP+CL
Sbjct: 301 VFLGHTAIDEMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIPLGPNVLPVCL 360

Query: 579 PDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMF 638
           PDN+T Y  GL+GYVSGFG+    +  +L++ RLPVA  +AC  WL+ + R +VFS NMF
Sbjct: 361 PDNETLYRSGLLGYVSGFGMEMGWLTTELKYSRLPVAPREACNAWLQKRQRPEVFSDNMF 420

Query: 639 CAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIK 698
           C G  + +   CQGDSG V+ V D +   WVATGIVSWGIGC  GY FYTKVL+YVDWIK
Sbjct: 421 CVGDETQRHSVCQGDSGSVYVVWDNHAHHWVATGIVSWGIGCGEGYDFYTKVLSYVDWIK 480

Query: 699 KEM 701
             M
Sbjct: 481 GVM 483



 Score =  127 bits (319), Expect = 4e-29
 Identities = 72/157 (45%), Positives = 94/157 (59%), Gaps = 3/157 (1%)

Query: 1   MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF 60
           MW L L      C   GS+ + Q+L  ++TSP +P+PY    E++T I  P G+ V+LVF
Sbjct: 24  MWWLLLWGVLQACPTRGSVLLAQELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVF 83

Query: 61  QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF 120
           Q FDLEPS+ C  D V IS       +FCGQ GSPLG PPG++EF+S G  + LTF T  
Sbjct: 84  QDFDLEPSQDCAGDSVTISFVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQP 143

Query: 121 SNEENGTIMFYKGFLAYYQ--AVDLDECASRSKLGEE 155
           S+ EN T   +KGFLA YQ  AV+  +  S +  G E
Sbjct: 144 SS-ENKTAHLHKGFLALYQTVAVNYSQPISEASRGSE 179



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 36/139 (25%), Positives = 58/139 (41%), Gaps = 17/139 (12%)

Query: 188 SCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQ 247
           +C    S  L  E    ++S  YP  Y      +  I+   G  + L F + FD++  Q 
Sbjct: 35  ACPTRGSVLLAQELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVF-QDFDLEPSQD 93

Query: 248 VHCPYDQLQIYANGKNIGEFCGKQ-----RPP---DLDTSSNAVDLLFFTDESGDS---- 295
             C  D + I   G +  +FCG+Q     RPP   +  +S  ++ L F T  S ++    
Sbjct: 94  --CAGDSVTISFVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQPSSENKTAH 151

Query: 296 --RGWKLRYTTEIIKCPQP 312
             +G+   Y T  +   QP
Sbjct: 152 LHKGFLALYQTVAVNYSQP 170


>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  306 bits (785), Expect = 3e-83
 Identities = 151/372 (40%), Positives = 221/372 (59%), Gaps = 15/372 (4%)

Query: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64

Query: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124

Query: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174

Query: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234

Query: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294

Query: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351

Query: 361 DGTWHRAMPRCK 372
           DGTW   +P CK
Sbjct: 352 DGTWSNKIPTCK 363


>gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
          Length = 406

 Score =  182 bits (461), Expect = 1e-45
 Identities = 115/358 (32%), Positives = 176/358 (49%), Gaps = 57/358 (15%)

Query: 368 MPRCKIKD-CGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGV 426
           +P C+  D C +P  + +G   ++           ++Y C   YYK++T         GV
Sbjct: 83  LPECEADDGCPKPPEIAHGYVEHS-----------VRYQCKN-YYKLRTEG------DGV 124

Query: 427 YTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGR 486
           YT   +  W N+  G+K+P C  VCGKP NP    QRI+GG     G+FPWQ     H  
Sbjct: 125 YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHN 184

Query: 487 --GGGALLGDRWILTAAHTLYPKEHEAQSNA-----SLDVFLGHTNVEELMKLGNHPIRR 539
              G  L+ ++W+LT A  L+   H   + A     +L +++G   + E        I +
Sbjct: 185 LTTGATLINEQWLLTTAKNLF-LNHSENATAKDIAPTLTLYVGKKQLVE--------IEK 235

Query: 540 VSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVM 599
           V +HP+Y Q        DI L++L+  V++   ++PICLP  D + ++G +GYVSG+G  
Sbjct: 236 VVLHPNYSQ-------VDIGLIKLKQKVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRN 287

Query: 600 EE-KIAHDLRFVRLPVANPQACENWLRGKNRMD------------VFSQNMFCAGHPSLK 646
              K    L++V LPVA+   C     G    +            + +++ FCAG    +
Sbjct: 288 ANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQ 347

Query: 647 QDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS-RGYGFYTKVLNYVDWIKKEMEE 703
           +D C GD+G  FAV D   D W ATGI+S+   C+   YG Y KV +  DW++K + E
Sbjct: 348 EDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAE 405



 Score = 34.3 bits (77), Expect = 0.41
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 7/56 (12%)

Query: 402 IQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNP 457
           ++Y C   YYK++T         GVYT   +  W N+  G+K+P C    G P  P
Sbjct: 48  VRYQCKN-YYKLRTEG------DGVYTLNDKKQWINKAVGDKLPECEADDGCPKPP 96


>gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]
          Length = 347

 Score =  178 bits (452), Expect = 1e-44
 Identities = 109/323 (33%), Positives = 163/323 (50%), Gaps = 45/323 (13%)

Query: 402 IQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQR 461
           ++Y C   YYK++T         GVYT   +  W N+  G+K+P C  VCGKP NP    
Sbjct: 48  VRYQCKN-YYKLRTEG------DGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPV 100

Query: 462 QRIIGGQKAKMGNFPWQVFTNIHGR--GGGALLGDRWILTAAHTLYPKEHEAQSNA---- 515
           QRI+GG     G+FPWQ     H     G  L+ ++W+LT A  L+   H   + A    
Sbjct: 101 QRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF-LNHSENATAKDIA 159

Query: 516 -SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLL 574
            +L +++G   + E        I +V +HP+Y Q        DI L++L+  V++   ++
Sbjct: 160 PTLTLYVGKKQLVE--------IEKVVLHPNYSQ-------VDIGLIKLKQKVSVNERVM 204

Query: 575 PICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANPQACENWLRGKNRMD-- 631
           PICLP  D + ++G +GYVSG+G     K    L++V LPVA+   C     G    +  
Sbjct: 205 PICLPSKD-YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKK 263

Query: 632 ----------VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS 681
                     + +++ FCAG    ++D C GD+G  FAV D   D W ATGI+S+   C+
Sbjct: 264 TPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCA 323

Query: 682 -RGYGFYTKVLNYVDWIKKEMEE 703
              YG Y KV +  DW++K + E
Sbjct: 324 VAEYGVYVKVTSIQDWVQKTIAE 346


>gi|45580723 haptoglobin-related protein [Homo sapiens]
          Length = 348

 Score =  172 bits (435), Expect = 1e-42
 Identities = 107/329 (32%), Positives = 164/329 (49%), Gaps = 44/329 (13%)

Query: 396 NTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPV 455
           N Y   +  Y  + YY+++T         GVYT   +  W N+  G+K+P C  VCGKP 
Sbjct: 42  NGYVEHLFRYQCKNYYRLRTEG------DGVYTLNDKKQWINKAVGDKLPECEAVCGKPK 95

Query: 456 NPVEQRQRIIGGQKAKMGNFPWQVFTNIHGR--GGGALLGDRWILTAAHTLYPKEHEAQS 513
           NP    QRI+GG     G+FPWQ     H     G  L+ ++W+LT A  L+   H   +
Sbjct: 96  NPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF-LNHSENA 154

Query: 514 NA-----SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVT 568
            A     +L +++G   + E        I +V +HP+Y Q        DI L++L+  V 
Sbjct: 155 TAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYHQ-------VDIGLIKLKQKVL 199

Query: 569 LGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANP---------Q 618
           +   ++PICLP  + + ++G +GYVSG+G  +  K+   L++V LPVA+           
Sbjct: 200 VNERVMPICLPSKN-YAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGS 258

Query: 619 ACENWLRGKNRMDV---FSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVS 675
            C  W   K+ + V    +++ FC G    ++D C GD+G  FAV D   D W A GI+S
Sbjct: 259 TCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILS 318

Query: 676 WGIGCS-RGYGFYTKVLNYVDWIKKEMEE 703
           +   C+   YG Y KV +   W++K + E
Sbjct: 319 FDKSCAVAEYGVYVKVTSIQHWVQKTIAE 347


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  149 bits (376), Expect = 9e-36
 Identities = 97/291 (33%), Positives = 150/291 (51%), Gaps = 37/291 (12%)

Query: 24  KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----S 79
           KL G +T+P +PK YP N      +  PT YR+ + F+ F+LE +E C YDYV+I    S
Sbjct: 624 KLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLS 683

Query: 80  ADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQ 139
           ++ K  G+FCG            +   SQ N M + F +D +  +       KGF A++ 
Sbjct: 684 SESKLHGKFCGA--------EVPEVITSQFNNMRIEFKSDNTVSK-------KGFKAHFF 728

Query: 140 AVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSC-QAECSSELY 198
           + D DEC S+   G       CQH C N +G Y C CR G+ L +++H C +AEC  +++
Sbjct: 729 S-DKDEC-SKDNGG-------CQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIH 779

Query: 199 TEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY 258
           +  SG I+S  +P  YP    C + I    G  + L F E F+I+ HQ+  C YD L+++
Sbjct: 780 S-PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVF 835

Query: 259 ----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTE 305
                    +G  CG + P  L  + N + + F +D S   +G++  ++TE
Sbjct: 836 DGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE 886



 Score =  133 bits (335), Expect = 5e-31
 Identities = 91/302 (30%), Positives = 150/302 (49%), Gaps = 38/302 (12%)

Query: 16  GGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDY 75
           GG I   +K  G++ SP +P  Y    E    ITV   Y V L FQ F++E  + C YDY
Sbjct: 463 GGEI---RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519

Query: 76  VKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFY 131
           +++    S +   +GRFCG            ++  S  N + + F +D      GT+   
Sbjct: 520 LEVRDGTSENSPLIGRFCGY--------DKPEDIRSTSNTLWMKFVSD------GTVN-K 564

Query: 132 KGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQA 191
            GF A +   + DECA   + G       C+  C N +G Y C+C PGYEL  DR SC+A
Sbjct: 565 AGFAANFFKEE-DECAKPDRGG-------CEQRCLNTLGSYQCACEPGYELGPDRRSCEA 616

Query: 192 ECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCP 251
            C   L T+ +G I++  +P+ YPP+  C + +       + +KF E F+++ ++   C 
Sbjct: 617 ACGG-LLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF-EFFELEGNEV--CK 672

Query: 252 YDQLQIY----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEII 307
           YD ++I+    +  K  G+FCG + P  + +  N + + F +D +   +G+K  + ++  
Sbjct: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKD 732

Query: 308 KC 309
           +C
Sbjct: 733 EC 734



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 73/285 (25%), Positives = 127/285 (44%), Gaps = 76/285 (26%)

Query: 27   GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI--SADKKS 84
            G +TSP +P  YP+  E T  I+   G+R+KL F +F++E  + C YD++++     +KS
Sbjct: 783  GLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS 842

Query: 85   --LGRFCG-QLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAV 141
              LGR CG ++  PL         ++ GNKM + F +D S +  G           +QA 
Sbjct: 843  PILGRLCGNKIPDPL---------VATGNKMFVRFVSDASVQRKG-----------FQAT 882

Query: 142  DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEA 201
               EC  R K  E  P+                                     +LY+ A
Sbjct: 883  HSTECGGRLK-AESKPR-------------------------------------DLYSHA 904

Query: 202  SGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY--- 258
                       +YP  + C + +  ERG  L L F + F++++  +  C YD ++++   
Sbjct: 905  QFG------DNNYPGQVDCEWLLVSERGSRLELSF-QTFEVEE--EADCGYDYVELFDGL 955

Query: 259  -ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
             +    +G FCG   P ++ +  ++V + F TD++ + +G+ +RY
Sbjct: 956  DSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 80/330 (24%), Positives = 126/330 (38%), Gaps = 84/330 (25%)

Query: 23  QKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD- 81
           Q+  G ++SP FP  YP+       ++V  G ++ L F   DL  S  C+YDY+++    
Sbjct: 354 QESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGY 413

Query: 82  -KKS--LGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYY 138
            +KS  LGRFCG            +   S  ++M + F +  +          KGF A Y
Sbjct: 414 WRKSPLLGRFCGD--------KLPEVLTSTDSRMWIEFRSSSN-------WVGKGFAAVY 458

Query: 139 QAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELY 198
           +A+                                                   C  E+ 
Sbjct: 459 EAI---------------------------------------------------CGGEI- 466

Query: 199 TEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQI- 257
            +  G I S  YP  Y P   C + I V     + L F + F+I+ H   +C YD L++ 
Sbjct: 467 RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTF-QSFEIERHD--NCAYDYLEVR 523

Query: 258 ---YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKT 314
                N   IG FCG  +P D+ ++SN + + F +D + +  G+   +  E  +C +P  
Sbjct: 524 DGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDR 583

Query: 315 LDEFTIIQNLQPQYQFRDYFIATCKQGYQL 344
                   N    YQ        C+ GY+L
Sbjct: 584 GGCEQRCLNTLGSYQ------CACEPGYEL 607



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 12/99 (12%)

Query: 38   YPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVK----ISADKKSLGRFCGQLG 93
            YP   +   ++    G R++L FQ F++E    C YDYV+    + +    LGRFCG   
Sbjct: 911  YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCG--- 967

Query: 94   SPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYK 132
                 PP  +E  S G+ +L+ FHTD +  + G  + YK
Sbjct: 968  ---SGPP--EEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 27/126 (21%), Positives = 56/126 (44%), Gaps = 7/126 (5%)

Query: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
           ++ + R   +     E   E++G +SS  +P  YP    C + + V  G  + L F    
Sbjct: 336 DIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT-- 393

Query: 241 DIDDHQQVHCPYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSR 296
            +D ++   C YD +++    +     +G FCG + P  L ++ + + + F +  +   +
Sbjct: 394 -MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGK 452

Query: 297 GWKLRY 302
           G+   Y
Sbjct: 453 GFAAVY 458


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  149 bits (376), Expect = 9e-36
 Identities = 94/290 (32%), Positives = 144/290 (49%), Gaps = 35/290 (12%)

Query: 24  KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----S 79
           KL G +TSP +PK YP N      +  P  YR+ L F+ F+LE ++ C YD+V++    S
Sbjct: 626 KLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLS 685

Query: 80  ADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQ 139
            D K  GRFCG            +   SQ N M + F +D +  +       +GF A++ 
Sbjct: 686 PDAKLHGRFCGS--------ETPEVITSQSNNMRVEFKSDNTVSK-------RGFRAHFF 730

Query: 140 AVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYT 199
           + D DECA  +          CQH C N  G Y C CR GY L E+ H C+    +   +
Sbjct: 731 S-DKDECAKDNG--------GCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKIS 781

Query: 200 EASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYA 259
              G ++S  +P  YP    C ++I    G  + L F E F+I+ HQ+  C YD L++Y 
Sbjct: 782 SVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNE-FEIEQHQE--CAYDHLEMYD 838

Query: 260 NGKN----IGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTE 305
              +    +G FCG ++P     S +++ L F++D S   +G++  ++TE
Sbjct: 839 GPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTE 888



 Score =  127 bits (318), Expect = 5e-29
 Identities = 88/349 (25%), Positives = 159/349 (45%), Gaps = 51/349 (14%)

Query: 27  GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----SADK 82
           G++ SP +P  Y  + E    ITV  G+ V L FQ F++E  + C YDY+++    + + 
Sbjct: 473 GQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEES 532

Query: 83  KSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFS-NEENGTIMFYKGFLAYYQAV 141
             +G FCG            ++  S  N++ + F +D S N+      F+K         
Sbjct: 533 ALIGHFCGY--------EKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFK--------- 575

Query: 142 DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEA 201
           ++DEC+     G       C+H C N +G Y C+C PGYEL  D+  C+  C     T+ 
Sbjct: 576 EVDECSWPDHGG-------CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGG-FITKL 627

Query: 202 SGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYA-- 259
           +G I+S  +P+ YP +  C + +       + L+F E F+++ +    C YD +++ +  
Sbjct: 628 NGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQF-EVFELEGNDV--CKYDFVEVRSGL 684

Query: 260 --NGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDE 317
             + K  G FCG + P  + + SN + + F +D +   RG++  + ++  +C +     +
Sbjct: 685 SPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQ 744

Query: 318 FTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHR 366
              +            ++  C+ GY L E           C++ G  H+
Sbjct: 745 HECVNTF-------GSYLCRCRNGYWLHENGH-------DCKEAGCAHK 779



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 76/300 (25%), Positives = 131/300 (43%), Gaps = 74/300 (24%)

Query: 13   CRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCF 72
            C+  G       + G + SP +P  YP+  E T  I+   G+RVKL F +F++E  + C 
Sbjct: 771  CKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECA 830

Query: 73   YDYVKISADKKS----LGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTI 128
            YD++++     S    LGRFC   GS   +P      ++ G+ M L F++D S +  G  
Sbjct: 831  YDHLEMYDGPDSLAPILGRFC---GSKKPDPT-----VASGSSMFLRFYSDASVQRKG-- 880

Query: 129  MFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHS 188
                     +QAV   EC  R K                             E+Q     
Sbjct: 881  ---------FQAVHSTECGGRLKA----------------------------EVQ----- 898

Query: 189  CQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQV 248
                 + ELY+ A           +YP + RC++ I  E G  + L F   F+++  ++ 
Sbjct: 899  -----TKELYSHAQ------FGDNNYPSEARCDWVIVAEDGYGVELTF-RTFEVE--EEA 944

Query: 249  HCPYDQLQIY----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTT 304
             C YD ++ Y    ++   +G FCG     ++ ++ +++ + F TD++ + +G+  RYT+
Sbjct: 945  DCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTS 1004



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 76/299 (25%), Positives = 120/299 (40%), Gaps = 80/299 (26%)

Query: 23  QKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD- 81
           Q   G  ++P FP  YP+       I+V  G ++ L F   DL  S  C+YDYV++    
Sbjct: 356 QDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGY 415

Query: 82  -KKS--LGRFCG-QLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAY 137
            +K+  LGRFCG ++  PL         +S  +++ + F +  +       +  KGF A 
Sbjct: 416 WRKAPLLGRFCGDKIPEPL---------VSTDSRLWVEFRSSSN-------ILGKGFFAA 459

Query: 138 YQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSEL 197
           Y+                                                   A C  ++
Sbjct: 460 YE---------------------------------------------------ATCGGDM 468

Query: 198 YTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQI 257
             +A G I S  YP  Y P   C + I V  G  + L F + F+I+ H    C YD L++
Sbjct: 469 NKDA-GQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTF-QAFEIERHDS--CAYDYLEV 524

Query: 258 ----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQP 312
                     IG FCG ++P D+ +SSN + + F +D S +  G+   +  E+ +C  P
Sbjct: 525 RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 19/118 (16%)

Query: 38   YPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVK----ISADKKSLGRFCGQLG 93
            YP+      VI    GY V+L F+ F++E    C YDY++      +    LGRFCG   
Sbjct: 913  YPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCG--S 970

Query: 94   SPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSK 151
             PL      +E  S G+ +++ F TD +  +       KGF A Y +    +     K
Sbjct: 971  GPL------EEIYSAGDSLMIRFRTDDTINK-------KGFHARYTSTKFQDALHMKK 1015


>gi|21264361 mannan-binding lectin serine protease 2 isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  145 bits (365), Expect = 2e-34
 Identities = 72/171 (42%), Positives = 101/171 (59%), Gaps = 10/171 (5%)

Query: 22  PQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD 81
           P+ +FG + SP FP  Y N+ E    +T P GYR++L F  FDLE S  C YD+VK+S+ 
Sbjct: 23  PEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG 82

Query: 82  KKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAV 141
            K L   CGQ  +     PGK  F S G+ + +TF +D+SNE+      + GF A+Y A 
Sbjct: 83  AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP-----FTGFEAFYAAE 137

Query: 142 DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAE 192
           D+DEC  +   GE    P C H CHN++GG++CSCR GY L  ++ +C  +
Sbjct: 138 DIDEC--QVAPGE---APTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSEQ 183



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 39/173 (22%), Positives = 68/173 (39%), Gaps = 33/173 (19%)

Query: 203 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGK 262
           G ++S  +P  Y  D    +++    G  L L F   FD++      C YD +++ +  K
Sbjct: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTH-FDLELSHL--CEYDFVKLSSGAK 84

Query: 263 NIGEFCGK-----QRPPDLDT---SSNAVDLLFFTDESGDS--RGWKLRYTTEIIKCPQP 312
            +   CG+     +R P  DT     +++D+ F +D S +    G++  Y  E       
Sbjct: 85  VLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAE------- 137

Query: 313 KTLDEFTIIQNLQPQYQFRDY-----FIATCKQGYQLIEGNQVLHSFTAVCQD 360
             +DE  +     P      +     F  +C+ GY       VLH     C +
Sbjct: 138 -DIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGY-------VLHRNKRTCSE 182


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  142 bits (359), Expect = 8e-34
 Identities = 94/291 (32%), Positives = 143/291 (49%), Gaps = 37/291 (12%)

Query: 24  KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----S 79
           KL G +TSP +PK YP N      +  PT YR+ L F  F+ E ++ C YD+V++    +
Sbjct: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656

Query: 80  ADKKSLGRFCGQLGSPLGNPPGKKEFM-SQGNKMLLTFHTDFSNEENGTIMFYKGFLAYY 138
           AD K  G+FCG           K E + SQ N M + F +D +  +       KGF A++
Sbjct: 657 ADSKLHGKFCGS---------EKPEVITSQYNNMRVEFKSDNTVSK-------KGFKAHF 700

Query: 139 QAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELY 198
            + D DEC S+   G       CQ  C N  G Y C CR G+ L +++H C+        
Sbjct: 701 FS-DKDEC-SKDNGG-------CQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKV 751

Query: 199 TEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY 258
           T  SG I+S  +P  YP    C ++I    G  + L F+E   +D   Q  C YD L+++
Sbjct: 752 TSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFME---MDIESQPECAYDHLEVF 808

Query: 259 ----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTE 305
               A    +G FCG ++P  +  + + + L F++D S   +G++  + TE
Sbjct: 809 DGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATE 859



 Score =  125 bits (315), Expect = 1e-28
 Identities = 84/303 (27%), Positives = 149/303 (49%), Gaps = 40/303 (13%)

Query: 16  GGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDY 75
           GG +   +K +G + SP +P  Y  +      I V  G+ V L FQ F++E  + C YDY
Sbjct: 436 GGDV---KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492

Query: 76  VKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFS-NEENGTIMF 130
           +++    S     +GR+CG             +  S  +++ L F +D S N+    + F
Sbjct: 493 LEVRDGHSESSTLIGRYCGY--------EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 131 YKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQ 190
           +K         ++DEC+  ++ G       C+  C N +G Y CSC PGYEL  D+  C+
Sbjct: 545 FK---------EVDECSRPNRGG-------CEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588

Query: 191 AECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHC 250
           A C   L T+ +G I+S  +P+ YPP+  C + +       + L+F + F+ + +    C
Sbjct: 589 AACGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV--C 644

Query: 251 PYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEI 306
            YD +++     A+ K  G+FCG ++P  + +  N + + F +D +   +G+K  + ++ 
Sbjct: 645 KYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDK 704

Query: 307 IKC 309
            +C
Sbjct: 705 DEC 707



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 70/302 (23%), Positives = 124/302 (41%), Gaps = 78/302 (25%)

Query: 13  CRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCF 72
           C+  G         G +TSP +P  YP+  E T  I+   G+RVKL F + D+E    C 
Sbjct: 742 CKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECA 801

Query: 73  YDYVKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTI 128
           YD++++     A    LGRFCG            +  ++ G++M L F++D S +  G  
Sbjct: 802 YDHLEVFDGRDAKAPVLGRFCGS--------KKPEPVLATGSRMFLRFYSDNSVQRKG-- 851

Query: 129 MFYKGFLAYYQAVDLDECAS--RSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDR 186
                    +QA    EC    R+ +  +D     Q   +NY GG               
Sbjct: 852 ---------FQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGG--------------- 887

Query: 187 HSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQ 246
                                          + C + I  E G  + L F + F+++  +
Sbjct: 888 -------------------------------VDCEWVIVAEEGYGVELVF-QTFEVE--E 913

Query: 247 QVHCPYDQLQIY----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
           +  C YD ++++    +    +G +CG   P ++ ++ ++V + F +D++   +G+ LRY
Sbjct: 914 ETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973

Query: 303 TT 304
           T+
Sbjct: 974 TS 975



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 74/294 (25%), Positives = 121/294 (41%), Gaps = 78/294 (26%)

Query: 27  GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD---KK 83
           G  +SP +P  Y  +      I+V  G ++ L F   DL  S  C+YDYV++      K 
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  SL-GRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVD 142
            L GRFCG   S L  P      +S  +++ + F +  +          KGF A Y+A+ 
Sbjct: 391 PLRGRFCG---SKLPEP-----IVSTDSRLWVEFRSSSN-------WVGKGFFAVYEAI- 434

Query: 143 LDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEAS 202
                                            C  G ++++D                 
Sbjct: 435 ---------------------------------C--GGDVKKDY---------------- 443

Query: 203 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGK 262
           G+I S  YP  Y P   C + I+V  G  + L F + F+I+ H    C YD L++     
Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHS 500

Query: 263 N----IGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQP 312
                IG +CG ++P D+ ++S+ + L F +D S +  G+ + +  E+ +C +P
Sbjct: 501 ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 26/122 (21%), Positives = 54/122 (44%), Gaps = 7/122 (5%)

Query: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
           ++ + R   +     E   +++G  SS EYP  Y   + C + I V  G  + L F    
Sbjct: 309 DIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT--- 365

Query: 241 DIDDHQQVHCPYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSR 296
            +D ++   C YD +++    +      G FCG + P  + ++ + + + F +  +   +
Sbjct: 366 SLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGK 425

Query: 297 GW 298
           G+
Sbjct: 426 GF 427


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  141 bits (356), Expect = 2e-33
 Identities = 94/269 (34%), Positives = 137/269 (50%), Gaps = 40/269 (14%)

Query: 463 RIIGGQKAKMGNFPWQVFTNIHGRG----GGALLGDRWILTAAHTL-YPKEHEAQSNASL 517
           RI+ G  A++G  PWQV            G +L+ DRW+LTAAH L YP   +  +   L
Sbjct: 363 RIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL 422

Query: 518 DVFLG-------HTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLG 570
            V +G         N+E++  L      ++ +HP Y   E  N + DIAL++L+  V   
Sbjct: 423 LVRIGKHSRTRYERNIEKISML-----EKIYIHPRYNWRE--NLDRDIALMKLKKPVAFS 475

Query: 571 PNLLPICLPDNDTFYDL---GLMGYVSGFGVMEEKIAHD--------LRFVRLPVANPQA 619
             + P+CLPD +T   L   G  G V+G+G ++E    +        L+ V LP+     
Sbjct: 476 DYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPV 535

Query: 620 CENWLRGKNRMDVFSQNMFCAGHP---SLKQDACQGDSGGVFAVRDPNTDRWVATGIVSW 676
           C++  R +      + NMFCAG+      + DAC+GDSGG F ++ P  +RW   GIVSW
Sbjct: 536 CKDSTRIR-----ITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSW 590

Query: 677 GIGCSRG--YGFYTKVLNYVDWIKKEMEE 703
           G GC R   YGFYT V     WI+K +++
Sbjct: 591 GEGCDRDGKYGFYTHVFRLKKWIQKVIDQ 619


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  139 bits (351), Expect = 7e-33
 Identities = 92/251 (36%), Positives = 134/251 (53%), Gaps = 28/251 (11%)

Query: 463 RIIGGQKAKMGNFPWQ-VFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDV 519
           RI+GGQ+ K G  PWQ +  N    G  GG +L + +ILTAAH LY  +          V
Sbjct: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR-------FKV 286

Query: 520 FLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP 579
            +G  N E+  + G   +  V V   + +     ++ DIA+L L+  +T   N+ P CLP
Sbjct: 287 RVGDRNTEQ--EEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLP 344

Query: 580 DNDTFYDLGLM----GYVSGFGVMEEKIAHD--LRFVRLPVANPQACENWLRGKNRMDVF 633
           + D + +  LM    G VSGFG   EK      L+ + +P  +  +C+      +   + 
Sbjct: 345 ERD-WAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCK-----LSSSFII 398

Query: 634 SQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVL 691
           +QNMFCAG+ + ++DACQGDSGG    R  +T  +  TGIVSWG GC+R   YG YTKV 
Sbjct: 399 TQNMFCAGYDTKQEDACQGDSGGPHVTRFKDT--YFVTGIVSWGEGCARKGKYGIYTKVT 456

Query: 692 NYVDWIKKEME 702
            ++ WI + M+
Sbjct: 457 AFLKWIDRSMK 467


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  137 bits (346), Expect = 3e-32
 Identities = 82/244 (33%), Positives = 132/244 (54%), Gaps = 18/244 (7%)

Query: 463 RIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDVF 520
           RI+GG  +  G +PWQ    + GR   GGAL+ DRW++TAAH    +E    S     VF
Sbjct: 576 RIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCF--QEDSMASTVLWTVF 633

Query: 521 LGHT-NVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP 579
           LG            +  + R+ +HP Y +++S+++  D+ALL+L++ V     + P+CLP
Sbjct: 634 LGKVWQNSRWPGEVSFKVSRLLLHP-YHEEDSHDY--DVALLQLDHPVVRSAAVRPVCLP 690

Query: 580 DNDTFYDLGLMGYVSGFGVMEE--KIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNM 637
               F++ GL  +++G+G + E   I++ L+ V + +     C    R +      +  M
Sbjct: 691 ARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQ-----VTPRM 745

Query: 638 FCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRG--YGFYTKVLNYVD 695
            CAG+   K+DACQGDSGG    +   + RW   G+VSWG+GC R   +G YT++   + 
Sbjct: 746 LCAGYRKGKKDACQGDSGGPLVCK-ALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIS 804

Query: 696 WIKK 699
           WI++
Sbjct: 805 WIQQ 808


>gi|148806900 epidermis-specific serine protease-like protein [Homo
           sapiens]
          Length = 328

 Score =  132 bits (332), Expect = 1e-30
 Identities = 86/265 (32%), Positives = 133/265 (50%), Gaps = 33/265 (12%)

Query: 448 LPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLY 505
           + VCG+PV       R++GGQ A  G +PWQV  +       GG+L+ +R ILTAAH + 
Sbjct: 16  ISVCGQPV----YSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQ 71

Query: 506 PKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN 565
           P      +  S  V+LG   V +  K   + + ++ +HP Y+   +     D+ALL+L +
Sbjct: 72  P----TWTTFSYTVWLGSITVGDSRKRVKYYVSKIVIHPKYQDTTA-----DVALLKLSS 122

Query: 566 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHD----LRFVRLPVANPQACE 621
            VT    +LPICLP       +    +V+G+G ++E    D    L+   +P+ + QACE
Sbjct: 123 QVTFTSAILPICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACE 182

Query: 622 NWLRGKNRMDVF--------SQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGI 673
                 N + +F         ++  CAG     +D+C+GDSGG  +        W+ TG+
Sbjct: 183 QLY---NPIGIFLPALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGV--WIQTGV 237

Query: 674 VSWGIGCSRGY-GFYTKVLNYVDWI 697
           VSWG+ C +   G YT V+ Y  WI
Sbjct: 238 VSWGLECGKSLPGVYTNVIYYQKWI 262


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  132 bits (331), Expect = 1e-30
 Identities = 89/248 (35%), Positives = 133/248 (53%), Gaps = 26/248 (10%)

Query: 463 RIIGGQKAKMGNFPWQVFTN--IHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVF 520
           R++GG+ AK G FPWQV  N  +    GG+++ ++WI+TAAH +       ++   + V 
Sbjct: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCV-------ETGVKITVV 278

Query: 521 LGHTNVEELMKLGN-HPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP 579
            G  N+EE         + R+  H +Y    +  +  DIALLEL+  + L   + PIC+ 
Sbjct: 279 AGEHNIEETEHTEQKRNVIRIIPHHNYNAAIN-KYNHDIALLELDEPLVLNSYVTPICIA 337

Query: 580 DND---TFYDLGLMGYVSGFGVMEEK--IAHDLRFVRLPVANPQACENWLRGKNRMDVFS 634
           D +    F   G  GYVSG+G +  K   A  L+++R+P+ +   C   LR   +  +++
Sbjct: 338 DKEYTNIFLKFG-SGYVSGWGRVFHKGRSALVLQYLRVPLVDRATC---LRS-TKFTIYN 392

Query: 635 QNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSR--GYGFYTKVLN 692
            NMFCAG     +D+CQGDSGG        T     TGI+SWG  C+    YG YTKV  
Sbjct: 393 -NMFCAGFHEGGRDSCQGDSGGPHVTEVEGTS--FLTGIISWGEECAMKGKYGIYTKVSR 449

Query: 693 YVDWIKKE 700
           YV+WIK++
Sbjct: 450 YVNWIKEK 457



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 29/118 (24%), Positives = 45/118 (38%), Gaps = 12/118 (10%)

Query: 160 QCQHLCHNYVGG-YFCSCRPGYELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDL 218
           +C+  C N       CSC  GY L E++ SC+          +    S L    +  PD+
Sbjct: 140 RCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDV 199

Query: 219 RCNYSIRVERGLTLHLKFLEPFDI-------DDHQQVHCPYDQLQIYANGKNIGEFCG 269
               S   E  L    +  + F+        +D +    P+   Q+  NGK +  FCG
Sbjct: 200 DYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW---QVVLNGK-VDAFCG 253


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  129 bits (324), Expect = 9e-30
 Identities = 85/256 (33%), Positives = 133/256 (51%), Gaps = 31/256 (12%)

Query: 461 RQRIIGGQKAKMGNFPWQVFTNIHGRG-------GGALLGDRWILTAAHTLYPKEHEAQS 513
           + RI+GG  +  G +PWQV   +H          GG+++G++WILTAAH  Y  E    S
Sbjct: 385 KPRIVGGTASVRGEWPWQV--TLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE----S 438

Query: 514 NASLDVFLGHTNVEELMK-LGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPN 572
              L V+ G  N  E+ +      ++ + +H  Y+  ES     DIALL+LE +V    +
Sbjct: 439 PKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAES---GYDIALLKLETTVNYTDS 495

Query: 573 LLPICLPD----NDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKN 628
             PICLP     N  + D  + G+  G+  + +KI + L+  ++P+   + C+   RG  
Sbjct: 496 QRPICLPSKGDRNVIYTDCWVTGW--GYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHK 553

Query: 629 RMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGY--GF 686
                +  M CAG+    +DAC+GDSGG  + +  + + W   GI SWG GC++    G 
Sbjct: 554 ----ITHKMICAGYREGGKDACKGDSGGPLSCK--HNEVWHLVGITSWGEGCAQRERPGV 607

Query: 687 YTKVLNYVDWIKKEME 702
           YT V+ YVDWI ++ +
Sbjct: 608 YTNVVEYVDWILEKTQ 623


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  126 bits (316), Expect = 8e-29
 Identities = 86/306 (28%), Positives = 149/306 (48%), Gaps = 40/306 (13%)

Query: 16  GGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDY 75
           GG +   +K +G + SP +P  Y  +      I V  G+ V L FQ F++E  + C YDY
Sbjct: 436 GGDV---KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492

Query: 76  VKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFS-NEENGTIMF 130
           +++    S     +GR+CG             +  S  +++ L F +D S N+    + F
Sbjct: 493 LEVRDGHSESSTLIGRYCGY--------EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 131 YKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQ 190
           +K         ++DEC+  ++ G       C+  C N +G Y CSC PGYEL  D+  C+
Sbjct: 545 FK---------EVDECSRPNRGG-------CEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588

Query: 191 AECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHC 250
           A C   L T+ +G I+S  +P+ YPP+  C + +       + L+F + F+ + +    C
Sbjct: 589 AACGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV--C 644

Query: 251 PYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEI 306
            YD +++     A+ K  G+FCG ++P  + +  N + + F +D +   +G+K  + +E 
Sbjct: 645 KYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEK 704

Query: 307 IKCPQP 312
               QP
Sbjct: 705 RPALQP 710



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 74/294 (25%), Positives = 122/294 (41%), Gaps = 78/294 (26%)

Query: 27  GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD---KK 83
           G  +SP +P  Y  +      I+V  G ++ L F   DL  S  C+YDYV++      K 
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  SL-GRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVD 142
            L GRFC   GS L  P      +S  +++ + F +  +          KGF A Y+A+ 
Sbjct: 391 PLRGRFC---GSKLPEP-----IVSTDSRLWVEFRSSSN-------WVGKGFFAVYEAI- 434

Query: 143 LDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEAS 202
              C                                G ++++D                 
Sbjct: 435 ---C--------------------------------GGDVKKD----------------Y 443

Query: 203 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQI----Y 258
           G+I S  YP  Y P   C + I+V  G  + L F + F+I+ H    C YD L++     
Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHS 500

Query: 259 ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQP 312
            +   IG +CG ++P D+ ++S+ + L F +D S +  G+ + +  E+ +C +P
Sbjct: 501 ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 26/122 (21%), Positives = 54/122 (44%), Gaps = 7/122 (5%)

Query: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
           ++ + R   +     E   +++G  SS EYP  Y   + C + I V  G  + L F    
Sbjct: 309 DIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT--- 365

Query: 241 DIDDHQQVHCPYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSR 296
            +D ++   C YD +++    +      G FCG + P  + ++ + + + F +  +   +
Sbjct: 366 SLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGK 425

Query: 297 GW 298
           G+
Sbjct: 426 GF 427


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  125 bits (313), Expect = 2e-28
 Identities = 87/263 (33%), Positives = 127/263 (48%), Gaps = 30/263 (11%)

Query: 451 CGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG----GGALLGDRWILTAAHTLYP 506
           CG+P        RI+GG+  + G +PWQ   +I  RG    GG+L+  +W+LTAAH    
Sbjct: 28  CGQP----RMSSRIVGGRDGRDGEWPWQA--SIQHRGAHVCGGSLIAPQWVLTAAHCFPR 81

Query: 507 KEHEAQSNASLDVF-LGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN 565
           +   A+    L    LG T+   L    + P+RRV + PDY +D +    GD+ALL+L  
Sbjct: 82  RALPAEYRVRLGALRLGSTSPRTL----SVPVRRVLLPPDYSEDGA---RGDLALLQLRR 134

Query: 566 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIA----HDLRFVRLPVANPQACE 621
            V L   + P+CLP        G    V+G+G +   +       L+ VR+P+ + + C+
Sbjct: 135 PVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCD 194

Query: 622 NWLRGKNRMD----VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWG 677
                   +     +      CAG+P   +DACQGDSGG        +  WV  G+VSWG
Sbjct: 195 GLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGS--WVLVGVVSWG 252

Query: 678 IGCS--RGYGFYTKVLNYVDWIK 698
            GC+     G YT V  Y  WI+
Sbjct: 253 KGCALPNRPGVYTSVATYSPWIQ 275


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  124 bits (310), Expect = 4e-28
 Identities = 95/302 (31%), Positives = 139/302 (46%), Gaps = 54/302 (17%)

Query: 441 GEKIPRCLPV----CGKPVNPVEQRQ----------------RIIGGQKAKMGNFPWQVF 480
           G+ + +C P     CG+P   +E+++                R+I G+  + G+ PWQV 
Sbjct: 169 GDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVV 228

Query: 481 TNIHGRG---GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLG-NHP 536
                +    G  L+   W+LTAAH +         +  L V LG  ++    K   +  
Sbjct: 229 LLDSKKKLACGAVLIHPSWVLTAAHCM-------DESKKLLVRLGEYDLRRWEKWELDLD 281

Query: 537 IRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDT----FYDLGLMGY 592
           I+ V VHP+Y +  + N   DIALL L    TL   ++PICLPD+          G    
Sbjct: 282 IKEVFVHPNYSKSTTDN---DIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETL 338

Query: 593 VSGFGV--MEEKIAHD-----LRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSL 645
           V+G+G     EK A       L F+++PV     C   +      ++ S+NM CAG    
Sbjct: 339 VTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS-----NMVSENMLCAGILGD 393

Query: 646 KQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS--RGYGFYTKVLNYVDWIKKEMEE 703
           +QDAC+GDSGG        T  W   G+VSWG GC     YG YTKV  Y+DWI   + +
Sbjct: 394 RQDACEGDSGGPMVASFHGT--WFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRD 451

Query: 704 ED 705
           ++
Sbjct: 452 KE 453



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 14/29 (48%), Positives = 16/29 (55%)

Query: 161 CQHLCHNYVGGYFCSCRPGYELQEDRHSC 189
           C H C   VG   CSC PGY+L +D   C
Sbjct: 147 CTHYCLEEVGWRRCSCAPGYKLGDDLLQC 175


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  124 bits (310), Expect = 4e-28
 Identities = 99/358 (27%), Positives = 158/358 (44%), Gaps = 39/358 (10%)

Query: 353 SFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYK 412
           S+  VCQDD  W+    R   +D G   N       + ++ G+      +       + K
Sbjct: 204 SWHPVCQDD--WNENYGRAACRDMGYKNN-------FYSSQGI------VDDSGSTSFMK 248

Query: 413 MQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKM 472
           + T AG+ +  + +Y   A        K     RC+  CG  +N   Q  RI+GG+ A  
Sbjct: 249 LNTSAGNVDIYKKLYHSDACS-----SKAVVSLRCI-ACGVNLNSSRQ-SRIVGGESALP 301

Query: 473 GNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELM 530
           G +PWQV  ++      GG+++   WI+TAAH +   E    +      F G      + 
Sbjct: 302 GAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCV---EKPLNNPWHWTAFAGILRQSFMF 358

Query: 531 KLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLM 590
               + + +V  HP+Y   +S     DIAL++L+  +T    + P+CLP+         +
Sbjct: 359 YGAGYQVEKVISHPNY---DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 415

Query: 591 GYVSGFGVMEE--KIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQD 648
            ++SG+G  EE  K +  L   ++ +   Q C +     N   + +  M CAG      D
Sbjct: 416 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDN---LITPAMICAGFLQGNVD 472

Query: 649 ACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGY--GFYTKVLNYVDWIKKEMEEE 704
           +CQGDSGG       N   W   G  SWG GC++ Y  G Y  V+ + DWI ++M  +
Sbjct: 473 SCQGDSGGPLVTSKNNI--WWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  124 bits (310), Expect = 4e-28
 Identities = 99/358 (27%), Positives = 158/358 (44%), Gaps = 39/358 (10%)

Query: 353 SFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYK 412
           S+  VCQDD  W+    R   +D G   N       + ++ G+      +       + K
Sbjct: 167 SWHPVCQDD--WNENYGRAACRDMGYKNN-------FYSSQGI------VDDSGSTSFMK 211

Query: 413 MQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKM 472
           + T AG+ +  + +Y   A        K     RC+  CG  +N   Q  RI+GG+ A  
Sbjct: 212 LNTSAGNVDIYKKLYHSDACS-----SKAVVSLRCI-ACGVNLNSSRQ-SRIVGGESALP 264

Query: 473 GNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELM 530
           G +PWQV  ++      GG+++   WI+TAAH +   E    +      F G      + 
Sbjct: 265 GAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCV---EKPLNNPWHWTAFAGILRQSFMF 321

Query: 531 KLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLM 590
               + + +V  HP+Y   +S     DIAL++L+  +T    + P+CLP+         +
Sbjct: 322 YGAGYQVEKVISHPNY---DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 378

Query: 591 GYVSGFGVMEE--KIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQD 648
            ++SG+G  EE  K +  L   ++ +   Q C +     N   + +  M CAG      D
Sbjct: 379 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDN---LITPAMICAGFLQGNVD 435

Query: 649 ACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGY--GFYTKVLNYVDWIKKEMEEE 704
           +CQGDSGG       N   W   G  SWG GC++ Y  G Y  V+ + DWI ++M  +
Sbjct: 436 SCQGDSGGPLVTSKNNI--WWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 491


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  124 bits (310), Expect = 4e-28
 Identities = 83/296 (28%), Positives = 145/296 (48%), Gaps = 40/296 (13%)

Query: 16  GGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDY 75
           GG +   +K +G + SP +P  Y  +      I V  G+ V L FQ F++E  + C YDY
Sbjct: 436 GGDV---KKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDY 492

Query: 76  VKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFS-NEENGTIMF 130
           +++    S     +GR+CG             +  S  +++ L F +D S N+    + F
Sbjct: 493 LEVRDGHSESSTLIGRYCGY--------EKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 131 YKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQ 190
           +K         ++DEC+  ++ G       C+  C N +G Y CSC PGYEL  D+  C+
Sbjct: 545 FK---------EVDECSRPNRGG-------CEQRCLNTLGSYKCSCDPGYELAPDKRRCE 588

Query: 191 AECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHC 250
           A C   L T+ +G I+S  +P+ YPP+  C + +       + L+F + F+ + +    C
Sbjct: 589 AACGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV--C 644

Query: 251 PYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
            YD +++     A+ K  G+FCG ++P  + +  N + + F +D +   +G+K  +
Sbjct: 645 KYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 74/294 (25%), Positives = 121/294 (41%), Gaps = 78/294 (26%)

Query: 27  GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD---KK 83
           G  +SP +P  Y  +      I+V  G ++ L F   DL  S  C+YDYV++      K 
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  SL-GRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVD 142
            L GRFCG   S L  P      +S  +++ + F +  +          KGF A Y+A+ 
Sbjct: 391 PLRGRFCG---SKLPEP-----IVSTDSRLWVEFRSSSN-------WVGKGFFAVYEAI- 434

Query: 143 LDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEAS 202
                                            C  G ++++D                 
Sbjct: 435 ---------------------------------C--GGDVKKDY---------------- 443

Query: 203 GYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGK 262
           G+I S  YP  Y P   C + I+V  G  + L F + F+I+ H    C YD L++     
Sbjct: 444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHS 500

Query: 263 N----IGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQP 312
                IG +CG ++P D+ ++S+ + L F +D S +  G+ + +  E+ +C +P
Sbjct: 501 ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 19/122 (15%)

Query: 24  KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----S 79
           KL G +TSP +PK YP N      +  PT YR+ L F  F+ E ++ C YD+V++    +
Sbjct: 597 KLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLT 656

Query: 80  ADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQ 139
           AD K  G+FCG            +   SQ N M + F +D         +  KGF A++ 
Sbjct: 657 ADSKLHGKFCGS--------EKPEVITSQYNNMRVEFKSD-------NTVSKKGFKAHFF 701

Query: 140 AV 141
           +V
Sbjct: 702 SV 703



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 26/122 (21%), Positives = 54/122 (44%), Gaps = 7/122 (5%)

Query: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
           ++ + R   +     E   +++G  SS EYP  Y   + C + I V  G  + L F    
Sbjct: 309 DIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT--- 365

Query: 241 DIDDHQQVHCPYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSR 296
            +D ++   C YD +++    +      G FCG + P  + ++ + + + F +  +   +
Sbjct: 366 SLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGK 425

Query: 297 GW 298
           G+
Sbjct: 426 GF 427


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  123 bits (309), Expect = 5e-28
 Identities = 85/276 (30%), Positives = 137/276 (49%), Gaps = 34/276 (12%)

Query: 441 GEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWIL 498
           G +  +    CG+P        R++GGQ  + G +PWQV    +G    GG+L+ ++W+L
Sbjct: 16  GSQRAKAATACGRP----RMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVL 71

Query: 499 TAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHP----IRRVSVHPDYRQDESYNF 554
           TAAH            +   V LG     +L++ G H     +R+V  +P Y+   S   
Sbjct: 72  TAAHCF----RNTSETSLYQVLLG---ARQLVQPGPHAMYARVRQVESNPLYQGTAS--- 121

Query: 555 EGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFG-VMEEKIAHDLRFVR-- 611
             D+AL+ELE  V     +LP+CLPD    ++ G+  +V+G+G   EE +  + R ++  
Sbjct: 122 SADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKL 181

Query: 612 -LPVANPQACENWLRGKN-----RMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNT 665
            +P+ +   C N L  K+     +      +M CAG    K+DAC+GDSGG        +
Sbjct: 182 AVPIIDTPKC-NLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQS 240

Query: 666 DRWVATGIVSWGIGCSRGY--GFYTKVLNYVDWIKK 699
             W+  G++SWG GC+R    G Y +V  + +WI +
Sbjct: 241 --WLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHR 274


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  122 bits (306), Expect = 1e-27
 Identities = 83/258 (32%), Positives = 128/258 (49%), Gaps = 21/258 (8%)

Query: 458 VEQRQRIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNA 515
           V  + RI GG  A  G +PWQV     G    GG+L+ ++W+L+AAH  +P EH  ++  
Sbjct: 39  VAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHC-FPSEHHKEA-- 95

Query: 516 SLDVFLGHTNVEELMKLGN-HPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLL 574
             +V LG   ++   +      ++ +  HP Y Q+ S   +GDIALL+L   +T    + 
Sbjct: 96  -YEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGS---QGDIALLQLSRPITFSRYIR 151

Query: 575 PICLPDNDTFYDLGLMGYVSGFGVMEEKIA----HDLRFVRLPVANPQACE---NWLRGK 627
           PICLP  +  +  GL   V+G+G +   ++      L+ + +P+ + + C    N     
Sbjct: 152 PICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKP 211

Query: 628 NRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS--RGYG 685
                  ++M CAG+    +DACQGDSGG  +   P    W  TGIVSWG  C      G
Sbjct: 212 EEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC--PVEGLWYLTGIVSWGDACGARNRPG 269

Query: 686 FYTKVLNYVDWIKKEMEE 703
            YT   +Y  WI+ ++ E
Sbjct: 270 VYTLASSYASWIQSKVTE 287


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  122 bits (306), Expect = 1e-27
 Identities = 81/245 (33%), Positives = 123/245 (50%), Gaps = 20/245 (8%)

Query: 462 QRIIGGQKAKMGNFPWQVFTNIHGRG--GGALLGDRWILTAAHTLYPKEHEAQSNASLDV 519
           QRI+GG +A+ G++PWQV   ++     GG+L+ + WILTAAH         +SN++   
Sbjct: 185 QRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCF-------RSNSNPRD 237

Query: 520 FLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLP 579
           ++  + +          +R + +H +Y+   S   E DIAL+ LENSVT   ++  +CLP
Sbjct: 238 WIATSGISTTFPKLRMRVRNILIHNNYK---SATHENDIALVRLENSVTFTKDIHSVCLP 294

Query: 580 DNDTFYDLGLMGYVSGFGVME--EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNM 637
                   G   YV+G+G  E       +LR  ++ + +   C       +        M
Sbjct: 295 AATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCN---APHSYNGAILSGM 351

Query: 638 FCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCS--RGYGFYTKVLNYVD 695
            CAG P    DACQGDSGG   V++ +   W   GIVSWG  C      G YT+V  Y+D
Sbjct: 352 LCAGVPQGGVDACQGDSGGPL-VQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLD 410

Query: 696 WIKKE 700
           WI+++
Sbjct: 411 WIRQQ 415


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,680,152
Number of Sequences: 37866
Number of extensions: 1592388
Number of successful extensions: 5177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 2867
Number of HSP's gapped (non-prelim): 1547
length of query: 705
length of database: 18,247,518
effective HSP length: 109
effective length of query: 596
effective length of database: 14,120,124
effective search space: 8415593904
effective search space used: 8415593904
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.