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Search of human proteins with 65301141
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
(1323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 2646 0.0
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 1290 0.0
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 153 1e-36
gi|238908508 leucine-rich repeat and death domain-containing pro... 132 3e-30
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 131 4e-30
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 124 8e-28
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 124 8e-28
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 115 4e-25
gi|45827729 scribble isoform b [Homo sapiens] 111 5e-24
gi|45827731 scribble isoform a [Homo sapiens] 111 5e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 110 7e-24
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 105 4e-22
gi|4503743 flightless I homolog [Homo sapiens] 98 6e-20
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 97 1e-19
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 95 4e-19
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 93 1e-18
gi|225579152 insulin-like growth factor binding protein, acid la... 91 7e-18
gi|4826772 insulin-like growth factor binding protein, acid labi... 91 7e-18
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 91 1e-17
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 89 3e-17
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 86 2e-16
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 86 2e-16
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 86 2e-16
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 86 2e-16
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 85 4e-16
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 85 4e-16
gi|197333692 leucine rich repeat containing 8 family, member B [... 80 2e-14
gi|21245134 leucine rich repeat containing 8 family, member B [H... 80 2e-14
gi|7706093 toll-like receptor 7 [Homo sapiens] 79 2e-14
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 79 4e-14
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 2646 bits (6859), Expect = 0.0
Identities = 1323/1323 (100%), Positives = 1323/1323 (100%)
Query: 1 MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSS 60
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSS
Sbjct: 1 MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSS 60
Query: 61 DLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPV 120
DLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPV
Sbjct: 61 DLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPV 120
Query: 121 RIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTC 180
RIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTC
Sbjct: 121 RIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTC 180
Query: 181 LIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQ 240
LIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQ
Sbjct: 181 LIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQ 240
Query: 241 RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQ 300
RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQ
Sbjct: 241 RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQ 300
Query: 301 LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTL 360
LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTL
Sbjct: 301 LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTL 360
Query: 361 PEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV 420
PEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV
Sbjct: 361 PEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV 420
Query: 421 DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF 480
DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF
Sbjct: 421 DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF 480
Query: 481 SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV
Sbjct: 481 SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
Query: 541 PVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLN 600
PVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLN
Sbjct: 541 PVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLN 600
Query: 601 ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFP 660
ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFP
Sbjct: 601 ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFP 660
Query: 661 ASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDL 720
ASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDL
Sbjct: 661 ASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDL 720
Query: 721 SCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVT 780
SCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVT
Sbjct: 721 SCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVT 780
Query: 781 STFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLL 840
STFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLL
Sbjct: 781 STFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLL 840
Query: 841 EEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGT 900
EEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGT
Sbjct: 841 EEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGT 900
Query: 901 CQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYP 960
CQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYP
Sbjct: 901 CQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYP 960
Query: 961 WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSY 1020
WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSY
Sbjct: 961 WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSY 1020
Query: 1021 GCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEF 1080
GCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEF
Sbjct: 1021 GCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEF 1080
Query: 1081 SSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSS 1140
SSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSS
Sbjct: 1081 SSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSS 1140
Query: 1141 NQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARG 1200
NQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARG
Sbjct: 1141 NQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARG 1200
Query: 1201 SCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE 1260
SCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE
Sbjct: 1201 SCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE 1260
Query: 1261 VPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFD 1320
VPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFD
Sbjct: 1261 VPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFD 1320
Query: 1321 TAL 1323
TAL
Sbjct: 1321 TAL 1323
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 1290 bits (3337), Expect = 0.0
Identities = 664/1223 (54%), Positives = 878/1223 (71%), Gaps = 50/1223 (4%)
Query: 130 DLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQL--HKWAERLVVLCGTCLIVSSVK 187
++GC+IRFY KP +RI LSG+YNVRKGK QL ++W R V+LCGTCLIVSSVK
Sbjct: 4 EIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVK 63
Query: 188 DCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVV 247
D TGKMH+LPL+GGK+EEVK+ Q+ LAFSS+G Q+QTY++ F+T EY RW RQ SKV
Sbjct: 64 DSLTGKMHVLPLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVA 123
Query: 248 SQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ----LERPGGLDTLYKFSQLKG 303
SQRIS+VDLSC SLE +P +LFYSQD+T+LNL+ NF++ L GL+ L +F++LK
Sbjct: 124 SQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKS 183
Query: 304 LNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEE 363
LNLS+N LG FP+ +C I TL ELN+SCN +P+ +G + NLQT LDGNFL +LP E
Sbjct: 184 LNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAE 243
Query: 364 LGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
L N++QLS LG+SFN F+ IPEV EKLT +D++ M+GNC+E L L L +M HIKHVDLR
Sbjct: 244 LENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLR 303
Query: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLR 483
+N ++ ++ + ++ +H+T +DLRDN+L DLD ++E LHC RNQL L + G+ L+
Sbjct: 304 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLK 363
Query: 484 TLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVR 543
LYASSN L ++VYPVP+ L+++D+SRN LE VP+W CE++K+EVLD+ +N + E+P R
Sbjct: 364 ALYASSNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPAR 423
Query: 544 ILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603
+ + SLRKL+ GHN + LP +E +EVLD+QHN L LP L KA +LR+LNASA
Sbjct: 424 LFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASA 483
Query: 604 NSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASK 663
N LESLP A EE+ S+LQ LYLTNN LTD+C+P+L GH HL+ILH+A N+LQ+FPASK
Sbjct: 484 NKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASK 543
Query: 664 LNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCN 723
+ KLE+LEE++LSGNKLK IPTTI NC+R+HT++AHSN I +FPE++QLP+I+ VDLSCN
Sbjct: 544 MAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCN 603
Query: 724 DLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTF 783
+L+E+ +PE LP LQ+LDLTGN LVL+HKTL++ ++I KIDQ T D++
Sbjct: 604 ELSEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNIRCFKIDQP--STGDASGAPAV 661
Query: 784 WSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEV 843
WSHG E +G +NKLCV+AL++++F + A+YG+FDGDRN E+P LLQCTM+D+L EE+
Sbjct: 662 WSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEEL 721
Query: 844 QQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGTCQA 903
Q++ N+ +M NTF+V RKLG AGQKLG +A+LC+I+ D DP SF+LT ANVG CQ
Sbjct: 722 QKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQT 781
Query: 904 VLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWIL 963
VLCR GKP+PLS+ + + + EE +R+K KAIITED KVNGVT TR+LG T+L+P ++
Sbjct: 782 VLCRNGKPLPLSRSYIMSCE-EELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVV 840
Query: 964 PKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQ 1023
P+PH+ S LT QDE ILG+K LW+ LS EAV AVR+V D LAAAKKLCTLAQSYGC
Sbjct: 841 PRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCH 900
Query: 1024 DNVGAMVVYLNIGEEG-CTCEMN---GLTLPGPVGFASTT--TIKDAPKP--ATPSSSSG 1075
D++ A+VV L++ E+ C CE++ + P P F + IKD P PSSSSG
Sbjct: 901 DSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSG 960
Query: 1076 IASEFSSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRP-ERRCSLHPTPTSGLFQRQPS 1134
+ASE SSE+STSE+SSEVGSTASDE G L P E+RC LHP S FQRQ S
Sbjct: 961 MASEISSELSTSEMSSEVGSTASDEPPPGALSENSPAYPSEQRCMLHPICLSNSFQRQLS 1020
Query: 1135 SATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCS 1194
SATFSS SDNGLDSDD++P+EGV TNGS+VEVEVDIHC R ++ E L++ P S
Sbjct: 1021 SATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIHCSRAKEKEKQQHLLQ-VPAEAS 1079
Query: 1195 EEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCL--YGKKLSNGSIVPLEDSL 1252
+E G+++ ++D L + S + G++ +NGS+ P E S
Sbjct: 1080 DE-----------------GIVISANEDEPGLPRKADFSAVGTIGRRRANGSVAPQERSH 1122
Query: 1253 NLIEVATEVPKRKT-GYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEED 1311
N+IEVAT+ P RK GYFAAP Q +P+DQF++P +LEEEVKE MK HQ+ + + +P
Sbjct: 1123 NVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPP 1182
Query: 1312 RTEP-----------PEEFDTAL 1323
+ +P P+ +DT L
Sbjct: 1183 QLQPQLPRHYQLDQLPDYYDTPL 1205
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 153 bits (386), Expect = 1e-36
Identities = 143/480 (29%), Positives = 224/480 (46%), Gaps = 42/480 (8%)
Query: 304 LNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEE 363
L+LS + + P + E++ LTEL L N LP+++G L+NL TL L N LT+LP+
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 364 LGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
L NL++L L + N +IP V +L L + + R N I
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL--------------RFNRI------ 204
Query: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTL---S 478
T V ++++ ++ + +R+N++ L ++ LC+L L NQL L +
Sbjct: 205 -----TTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGN 259
Query: 479 GFSLRTLYASSNRLTAV-NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537
+ L N L + + S L+ L L N L +P + +E L++ N +
Sbjct: 260 CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNI 319
Query: 538 TEVPVRILSSL-SLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKAL 594
+ +P +LSSL L L L N Q P + + L+++HN + ++P +FS+A
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379
Query: 595 NLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLV-GHLHLRILHLAN 653
L LN N L SLP SM++L TN L IP V G + L +L L+N
Sbjct: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTK---IPEDVSGLVSLEVLILSN 434
Query: 654 NQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPE-ILQL 712
N L+ P L L +L EL+L NKL+++P IA K L LV +N ++ P I L
Sbjct: 435 NLLKKLPHG-LGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHL 493
Query: 713 PQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
+ + L N LT + L++L L N NL L + S ++ + I+ PL
Sbjct: 494 TNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPL 553
Score = 124 bits (310), Expect = 8e-28
Identities = 116/403 (28%), Positives = 188/403 (46%), Gaps = 31/403 (7%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ-----LERPGGLDTLY--------- 296
+ T+ LS SL +P+ L + + L+LRHN ++ + R L TLY
Sbjct: 148 LMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV 207
Query: 297 -----KFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLC 351
S+L L++ NK+ P + E+ L L+++ N LP +IGN + L
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLD 267
Query: 352 LDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVL 411
L N L LP+ +GNL LS LG+ +N S IP K + L+ + + N + L +L
Sbjct: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLL 327
Query: 412 NRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCG 468
+ + + + L N + + I +++ NR+ + S L +L+
Sbjct: 328 SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
Query: 469 RNQLRELTL---SGFSLRTLYASSNRLTAV--NVYPVPSLLTFLDLSRNLLECVPDWACE 523
NQL L L + S+ L ++N+LT + +V + S L L LS NLL+ +P
Sbjct: 388 DNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS-LEVLILSNNLLKKLPHGLGN 446
Query: 524 AKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEVLDLQHNAL 582
+K+ LD+ N L +P I L+KL+L +N + LP + H+ L L L N L
Sbjct: 447 LRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLL 506
Query: 583 TRLPDTLFS-KALNLRYLNASANSLESLPSACTGEESLSMLQL 624
T LP+ + + + L YLN + N L SLP LS++ +
Sbjct: 507 THLPEEIGTLENLEELYLNDNPN-LHSLPFELALCSKLSIMSI 548
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 132 bits (331), Expect = 3e-30
Identities = 145/525 (27%), Positives = 247/525 (47%), Gaps = 58/525 (11%)
Query: 254 VDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGL 313
+++S + +P+ + +I L +N+++ P L+ L L+ L+L NKL
Sbjct: 216 LNVSHNHISHIPKEISQLGNIRQLFFYNNYIE-NFPSDLECL---GNLEILSLGKNKLRH 271
Query: 314 FPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSL 373
P L + TL LNL N P + L L +L L GN +++LP+E+ L+ L +L
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
Query: 374 GISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIE 433
+ N + + +L + + +A N LEV++ + N ++ + L N LK + E
Sbjct: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN-FRELRILILDKNLLKN-IPE 389
Query: 434 NLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELT--LSGF-SLRTLYAS 488
+ + + L DN+LT+L + L +L +LH RN + ++T +S ++ +L S
Sbjct: 390 KISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFS 449
Query: 489 SNRLTAVNV-YPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSS 547
N +T V + + ++LS N + P C + L V+ N ++E+PV I S
Sbjct: 450 GNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS 509
Query: 548 LSLRKLMLGHNHVQNLPTLVEH----IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASA 603
L L L N L EH I L+ LDL N + ++P ++ S ++L L
Sbjct: 510 KQLLHLELSEN---KLLIFSEHFCSLINLKYLDLGKNQIKKIPASI-SNMISLHVLILCC 565
Query: 604 NSLESLP-SACTGEESLSMLQLLYLTNNLL----TDQC-----------------IPVLV 641
N E+ P CT L LQ+L L+ N L +D C P+ +
Sbjct: 566 NKFETFPRELCT----LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIEL 621
Query: 642 GHL----HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLV 697
L L I + +L P +L+ + QL+EL++S N ++ IP I + L +L
Sbjct: 622 CQLQSLEQLNISQIKGRKLTRLP-GELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680
Query: 698 AHSNNISIF-PEILQLPQIQFVDLSCNDLTEILIPEALPATLQDL 741
A++N IS P +L L +Q ++LS N+LT ALP+ + ++
Sbjct: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLT------ALPSAIYNI 719
Score = 112 bits (279), Expect = 3e-24
Identities = 119/482 (24%), Positives = 204/482 (42%), Gaps = 79/482 (16%)
Query: 293 DTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCL 352
DTL L+ LNL +N+L FP LC + L L+L+ N LP +I L NL+TL +
Sbjct: 274 DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLM 333
Query: 353 DGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCL--------- 403
D N LT L E+ L ++ L ++ N I E L +++ N L
Sbjct: 334 DHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISC 393
Query: 404 ----EVLNLG---------VLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNR 450
E L+L ++++N+++ + + N++ + + + +I ++ N
Sbjct: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNM-VKITDCISHLNNICSLEFSGNI 452
Query: 451 LTD--LDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVP----SLL 504
+TD +++ + + ++ N++ L +L +LY S ++ PV L
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQL 512
Query: 505 TFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP 564
L+LS N L + C ++ LD+ N + ++P I + +SL L+L N + P
Sbjct: 513 LHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP 572
Query: 565 T-LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQ 623
L L+VLDL N L ++ + + ++ LN S+N P +SL L
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLK-GIQKLNFSSNQFIHFPIELCQLQSLEQLN 631
Query: 624 L-----------------------LYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTF 659
+ L ++NN + + IP +G L +L LH NNQ+
Sbjct: 632 ISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYL 689
Query: 660 PAS--KLNKLEQL--------------------EELNLSGNKLKTIPTTIANCKRLHTLV 697
P S LN L+QL +E+N N L P I K+L+T+
Sbjct: 690 PPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIA 749
Query: 698 AH 699
+
Sbjct: 750 RY 751
Score = 47.4 bits (111), Expect = 9e-05
Identities = 64/272 (23%), Positives = 108/272 (39%), Gaps = 35/272 (12%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRH-NFMQLER-PGGLDTLYKFSQLKGLNLSH 308
I ++ S P L Q + LN+ +L R PG L + +QLK L++S+
Sbjct: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNM---TQLKELDISN 660
Query: 309 NKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368
N + P + E+ L L+ N LP + +L +LQ L L GN LT LP + N+
Sbjct: 661 NAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720
Query: 369 QLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLK 428
L + N + P K L + +++ D R +
Sbjct: 721 SLKEINFDDNPLLRPPVEICKGKQLYTIA-----------------RYLQRADERDEKIL 763
Query: 429 TMVIENLEGNKHITHVDLRDNRL------TDLDLSSLCSLEQ-----LHCGRNQLRELTL 477
+ + + N T+ + +L TD+ S SL + L + Q +L+L
Sbjct: 764 EKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSL 823
Query: 478 SGFSLRTLYASSNRLTAVNVYPVPSLLTFLDL 509
+ +LR + LT + Y + +T L+L
Sbjct: 824 TAAALRDQLIRA--LTMIGAYEIMDKITALNL 853
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 131 bits (330), Expect = 4e-30
Identities = 146/529 (27%), Positives = 237/529 (44%), Gaps = 77/529 (14%)
Query: 266 EHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLT 325
E + D+T L + +N +Q D L L L++ N+L P + E+ L
Sbjct: 76 ERWWEQTDLTKLIISNNKLQ----SLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQ 131
Query: 326 ELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPE 385
+LN+S N LP +I NL NL+ L L N LT + E L L L +S N+ + +P
Sbjct: 132 KLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPA 191
Query: 386 VYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVD 445
+ L+ L R+ ++ N L+ L +NRM +KH+D N L+T+ E L G + + +
Sbjct: 192 SFSSLSSLVRLNLSSNELKSLP-AEINRMKRLKHLDCNSNLLETIPPE-LAGMESLELLY 249
Query: 446 LRDNRLTDLDLSSLCS-LEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLL 504
LR N+L L CS L++LH G NQ+ L A ++ + S+L
Sbjct: 250 LRRNKLRFLPEFPSCSLLKELHVGENQI-----------------EMLEAEHLKHLNSIL 292
Query: 505 TFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL- 563
LDL N L+ VPD + +E LD+S N ++ +P L +L L+ L L N ++ +
Sbjct: 293 V-LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS-LGNLHLKFLALEGNPLRTIR 350
Query: 564 -----------------------PTLVEH-------------------IPLEVLDLQHNA 581
P+ E I L++LD
Sbjct: 351 REIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQ 410
Query: 582 LTRLPDTLFS--KALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPV 639
T +PD +F K+ + +N S N L +P E M+ + L+ N L+ + +
Sbjct: 411 ATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMV--ELKEMVSDVDLSFNKLSFISLEL 468
Query: 640 LVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAH 699
V L L L NN L + P ++ L +L+ +NLS N+ K +P + L T++
Sbjct: 469 CVLQ-KLTFLDLRNNFLNSLP-EEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILIS 526
Query: 700 SNNI-SIFPEILQLPQ-IQFVDLSCNDLTEILIPEALPATLQDLDLTGN 746
+N + S+ P+ +++ + + +DL NDL +I L+ L L GN
Sbjct: 527 NNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 119 bits (298), Expect = 2e-26
Identities = 129/493 (26%), Positives = 213/493 (43%), Gaps = 85/493 (17%)
Query: 249 QRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSH 308
+ + +++S L+ +PE + +++ L L+HN + G + S L+ L+LS+
Sbjct: 128 ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEG----FEQLSNLEDLDLSN 183
Query: 309 NKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368
N L P +S+L LNLS N LP++I + L+ L + N L T+P EL ++
Sbjct: 184 NHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243
Query: 369 QLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLK 428
L L + N +PE + ++L + + N +E+L L +N I +DLR N LK
Sbjct: 244 SLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLK 302
Query: 429 TMVIENLEGNKHITHVDLRDNRLTDLDLSSL-CSLEQLHCGRNQLRELTLSGFSLRTLY- 486
+ V + + + + +DL +N D+SSL SL LH L+ L L G LRT+
Sbjct: 303 S-VPDEIILLRSLERLDLSNN-----DISSLPYSLGNLH-----LKFLALEGNPLRTIRR 351
Query: 487 ----------------------------ASSNRLTA-----VNVYPVPSLLTFLDLSRNL 513
A+ +T VN++ + +L LD S
Sbjct: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITL-KILDYSDKQ 410
Query: 514 LECVPDWACEAKKIEV---LDVSYNLLTEVPVRILSSLSL-RKLMLGHNHVQNLPT-LVE 568
+PD +A K + ++ S N L E+P R++ + + L N + + L
Sbjct: 411 ATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCV 470
Query: 569 HIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLT 628
L LDL++N L LP+ + S + L+ +N S N + LP
Sbjct: 471 LQKLTFLDLRNNFLNSLPEEMES-LVRLQTINLSFNRFKMLPE----------------- 512
Query: 629 NNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIA 688
VL L + ++NNQ+ + K+ +E L L+L N L IP +
Sbjct: 513 ----------VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELG 562
Query: 689 NCKRLHTLVAHSN 701
NC L TL+ N
Sbjct: 563 NCVNLRTLLLDGN 575
Score = 62.4 bits (150), Expect = 3e-09
Identities = 45/135 (33%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 247 VSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNL 306
+ + +S VDLS L + L Q +T+L+LR+NF+ P +++L + L+ +NL
Sbjct: 447 LKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLN-SLPEEMESLVR---LQTINL 502
Query: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFLTTLPEELG 365
S N+ + P +L I TL + +S N + P ++ + NL TL L N L +P ELG
Sbjct: 503 SFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELG 562
Query: 366 NLQQLSSLGISFNNF 380
N L +L + N F
Sbjct: 563 NCVNLRTLLLDGNPF 577
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 124 bits (310), Expect = 8e-28
Identities = 114/376 (30%), Positives = 188/376 (50%), Gaps = 31/376 (8%)
Query: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
TL EL L N +LP Q+ N +L L L N LTTLP + NL L L +S N +
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
Query: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN---- 438
PE + +L V + N + L G +N L +L +E L N
Sbjct: 107 FPENIKNCKVLTIVEASVNPISKLPDGFSQLLN------LTQLYLNDAFLEFLPANFGRL 160
Query: 439 KHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL-----TLSGFSLRTLYASSNR 491
+ ++LR+N+L L ++ L LE+L G N+ E+ LSG L+ + +NR
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSG--LKEFWMDANR 218
Query: 492 LTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS 549
LT + + + SL LT+LD+S+N +E V + + ++ L +S N L ++P I S +
Sbjct: 219 LTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLES 608
+ L + N + LP + I +E LD N + LP ++ + NLR A N L+
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQ 336
Query: 609 LPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKL 667
LP ++++ +L+L +N L + +P +G + L++++L++N+L+ P S KL
Sbjct: 337 LPPEIGSWKNIT---VLFLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLPFS-FTKL 390
Query: 668 EQLEELNLSGNKLKTI 683
+QL + LS N+ K +
Sbjct: 391 QQLTAMWLSDNQSKPL 406
Score = 98.6 bits (244), Expect = 4e-20
Identities = 85/273 (31%), Positives = 135/273 (49%), Gaps = 12/273 (4%)
Query: 504 LTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQN 562
+T LD S LE VP +K +E L + N + E+P ++ + SL KL L N +
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 563 LPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621
LP + + I L LD+ N + P+ + + + L + AS N + LP G L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD---GFSQLLN 139
Query: 622 LQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680
L LYL + L + +P G L L+IL L NQL+ P + +N+L QLE L+L N+
Sbjct: 140 LTQLYLNDAFL--EFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQLERLDLGSNEF 196
Query: 681 KTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATLQ 739
+P + L +N ++ P + L Q+ ++D+S N++ + + LQ
Sbjct: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 740 DLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
DL L+ N+ L +T+ +ITTLKID+ L
Sbjct: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQL 288
Score = 92.4 bits (228), Expect = 3e-18
Identities = 104/420 (24%), Positives = 188/420 (44%), Gaps = 67/420 (15%)
Query: 320 EISTLTELNLSCNGFHDLPSQIGNL-LNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFN 378
E T+T L+ S +P +I L+ L LD N + LP++L N Q L L + N
Sbjct: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
Query: 379 NFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN 438
+ + +P + N +N ++ +D+ N ++ EN++
Sbjct: 80 DLTTLPA-----------------------SIANLIN-LRELDVSKNGIQEFP-ENIKNC 114
Query: 439 KHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVN 496
K +T V+ N ++ L S L +L QL+ L+ L L A+ RLT +
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLY----------LNDAFLEFLPANFGRLTKLQ 164
Query: 497 VYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLML 555
+ L+L N L+ +P ++E LD+ N TEVP +L LS L++ +
Sbjct: 165 I---------LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWM 214
Query: 556 GHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACT 614
N + +P + + L LD+ N + + + + S NL+ L S+NSL+ LP
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETIG 273
Query: 615 GEESLSML-----QLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQ 669
++++ L QL+YL +++ G + + L + N+++ P+S + +L
Sbjct: 274 SLKNITTLKIDENQLMYLPDSI---------GGLISVEELDCSFNEVEALPSS-IGQLTN 323
Query: 670 LEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEI 728
L N L+ +P I + K + L HSN + PE + + +++ ++LS N L +
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Score = 85.1 bits (209), Expect = 4e-16
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 43/323 (13%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
++ V+ S + ++P+ ++T L L F++ P L K L+ L L N+
Sbjct: 117 LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTK---LQILELRENQ 172
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
L + P + ++ L L+L N F ++P + L L+ +D N LT +P +G+L+QL
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
+ L +S NN + E L ++++ N L+ L
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP----------------------- 269
Query: 431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLS---GFSLRTL 485
E + K+IT + + +N+L L + L S+E+L C N++ L S +LRT
Sbjct: 270 --ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 486 YASSNRLTAVNVYPVPSL-----LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
A N L + P + +T L L N LE +P+ + +K++V+++S N L +
Sbjct: 328 AADHNYLQQL----PPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 541 PVRILSSLSLRKLMLGHNHVQNL 563
P L + L N + L
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPL 406
Score = 72.8 bits (177), Expect = 2e-12
Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 41/295 (13%)
Query: 461 SLEQLHCGRNQLRELTLSGFSLRTLYASS---NRLTAVNVYPVPSLLTF--LDLSRNLLE 515
+LE+L+ NQ+ EL F+ ++L+ S N LT + + +L+ LD+S+N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA-SIANLINLRELDVSKNGIQ 105
Query: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEV 574
P+ K + +++ S N ++++P L+L +L L ++ LP + L++
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634
L+L+ N L LP T+ ++ L L+ +N +P E LS L+ ++ N LT
Sbjct: 166 LELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPEVL---EQLSGLKEFWMDANRLT- 220
Query: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLH 694
IP +G L+QL L++S N ++ + I+ C+ L
Sbjct: 221 -FIPGFIG-----------------------SLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 695 TLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPA--TLQDLDLTGN 746
L+ SN++ PE + L I + + N L + +P+++ ++++LD + N
Sbjct: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFN 309
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 124 bits (310), Expect = 8e-28
Identities = 114/376 (30%), Positives = 188/376 (50%), Gaps = 31/376 (8%)
Query: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
TL EL L N +LP Q+ N +L L L N LTTLP + NL L L +S N +
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
Query: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN---- 438
PE + +L V + N + L G +N L +L +E L N
Sbjct: 107 FPENIKNCKVLTIVEASVNPISKLPDGFSQLLN------LTQLYLNDAFLEFLPANFGRL 160
Query: 439 KHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL-----TLSGFSLRTLYASSNR 491
+ ++LR+N+L L ++ L LE+L G N+ E+ LSG L+ + +NR
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSG--LKEFWMDANR 218
Query: 492 LTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS 549
LT + + + SL LT+LD+S+N +E V + + ++ L +S N L ++P I S +
Sbjct: 219 LTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
Query: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLES 608
+ L + N + LP + I +E LD N + LP ++ + NLR A N L+
Sbjct: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQ 336
Query: 609 LPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKL 667
LP ++++ +L+L +N L + +P +G + L++++L++N+L+ P S KL
Sbjct: 337 LPPEIGSWKNIT---VLFLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLPFS-FTKL 390
Query: 668 EQLEELNLSGNKLKTI 683
+QL + LS N+ K +
Sbjct: 391 QQLTAMWLSDNQSKPL 406
Score = 98.6 bits (244), Expect = 4e-20
Identities = 85/273 (31%), Positives = 135/273 (49%), Gaps = 12/273 (4%)
Query: 504 LTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQN 562
+T LD S LE VP +K +E L + N + E+P ++ + SL KL L N +
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 563 LPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621
LP + + I L LD+ N + P+ + + + L + AS N + LP G L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD---GFSQLLN 139
Query: 622 LQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680
L LYL + L + +P G L L+IL L NQL+ P + +N+L QLE L+L N+
Sbjct: 140 LTQLYLNDAFL--EFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQLERLDLGSNEF 196
Query: 681 KTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATLQ 739
+P + L +N ++ P + L Q+ ++D+S N++ + + LQ
Sbjct: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 740 DLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
DL L+ N+ L +T+ +ITTLKID+ L
Sbjct: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQL 288
Score = 92.4 bits (228), Expect = 3e-18
Identities = 104/420 (24%), Positives = 188/420 (44%), Gaps = 67/420 (15%)
Query: 320 EISTLTELNLSCNGFHDLPSQIGNL-LNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFN 378
E T+T L+ S +P +I L+ L LD N + LP++L N Q L L + N
Sbjct: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
Query: 379 NFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN 438
+ + +P + N +N ++ +D+ N ++ EN++
Sbjct: 80 DLTTLPA-----------------------SIANLIN-LRELDVSKNGIQEFP-ENIKNC 114
Query: 439 KHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVN 496
K +T V+ N ++ L S L +L QL+ L+ L L A+ RLT +
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLY----------LNDAFLEFLPANFGRLTKLQ 164
Query: 497 VYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLML 555
+ L+L N L+ +P ++E LD+ N TEVP +L LS L++ +
Sbjct: 165 I---------LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWM 214
Query: 556 GHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACT 614
N + +P + + L LD+ N + + + + S NL+ L S+NSL+ LP
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETIG 273
Query: 615 GEESLSML-----QLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQ 669
++++ L QL+YL +++ G + + L + N+++ P+S + +L
Sbjct: 274 SLKNITTLKIDENQLMYLPDSI---------GGLISVEELDCSFNEVEALPSS-IGQLTN 323
Query: 670 LEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEI 728
L N L+ +P I + K + L HSN + PE + + +++ ++LS N L +
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Score = 85.1 bits (209), Expect = 4e-16
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 43/323 (13%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
++ V+ S + ++P+ ++T L L F++ P L K L+ L L N+
Sbjct: 117 LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTK---LQILELRENQ 172
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
L + P + ++ L L+L N F ++P + L L+ +D N LT +P +G+L+QL
Sbjct: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
+ L +S NN + E L ++++ N L+ L
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP----------------------- 269
Query: 431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLS---GFSLRTL 485
E + K+IT + + +N+L L + L S+E+L C N++ L S +LRT
Sbjct: 270 --ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 486 YASSNRLTAVNVYPVPSL-----LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
A N L + P + +T L L N LE +P+ + +K++V+++S N L +
Sbjct: 328 AADHNYLQQL----PPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 541 PVRILSSLSLRKLMLGHNHVQNL 563
P L + L N + L
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPL 406
Score = 72.8 bits (177), Expect = 2e-12
Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 41/295 (13%)
Query: 461 SLEQLHCGRNQLRELTLSGFSLRTLYASS---NRLTAVNVYPVPSLLTF--LDLSRNLLE 515
+LE+L+ NQ+ EL F+ ++L+ S N LT + + +L+ LD+S+N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA-SIANLINLRELDVSKNGIQ 105
Query: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEV 574
P+ K + +++ S N ++++P L+L +L L ++ LP + L++
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634
L+L+ N L LP T+ ++ L L+ +N +P E LS L+ ++ N LT
Sbjct: 166 LELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPEVL---EQLSGLKEFWMDANRLT- 220
Query: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLH 694
IP +G L+QL L++S N ++ + I+ C+ L
Sbjct: 221 -FIPGFIG-----------------------SLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 695 TLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPA--TLQDLDLTGN 746
L+ SN++ PE + L I + + N L + +P+++ ++++LD + N
Sbjct: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFN 309
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 115 bits (287), Expect = 4e-25
Identities = 120/452 (26%), Positives = 209/452 (46%), Gaps = 75/452 (16%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
IS +D S SL++VP+ +F NF + L+ L L N+
Sbjct: 24 ISVLDYSHCSLQQVPKEVF------------NFERT--------------LEELYLDANQ 57
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
+ P L L +L++ N +LP+ I +L+NL+ L + N + PE + + L
Sbjct: 58 IEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL 117
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
+ + S N S++P+ + +L L ++ + LE L R+ ++ ++LR NHLKT+
Sbjct: 118 TIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTL 176
Query: 431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSN 490
+++ + +DL +N +L L+Q+ LREL + +L+ L S
Sbjct: 177 P-KSMHKLAQLERLDLGNNEFGELPE----VLDQI----QNLRELWMDNNALQVLPGSIG 227
Query: 491 RLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSL 550
+L +L +LD+S+N +E V + +E L +S N+L ++P S+ L
Sbjct: 228 KL---------KMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP----DSIGL 274
Query: 551 RKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP 610
K L L + N LT LP+T+ + +L L + S N LESLP
Sbjct: 275 LK------------------KLTTLKVDDNQLTMLPNTIGNLSL-LEEFDCSCNELESLP 315
Query: 611 SACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQ 669
S L L+ L + N L + +P +G ++ ++ L +N+L+ P ++ ++++
Sbjct: 316 STI---GYLHSLRTLAVDENFLPE--LPREIGSCKNVTVMSLRSNKLEFLP-EEIGQMQK 369
Query: 670 LEELNLSGNKLKTIPTTIANCKRLHTLVAHSN 701
L LNLS N+LK +P + K L L N
Sbjct: 370 LRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Score = 104 bits (259), Expect = 6e-22
Identities = 111/382 (29%), Positives = 171/382 (44%), Gaps = 56/382 (14%)
Query: 256 LSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFP 315
L +EE+P+ LF Q + L++ N + P T+ LK L++S N + FP
Sbjct: 53 LDANQIEELPKQLFNCQALRKLSIPDNDLS-NLP---TTIASLVNLKELDISKNGVQEFP 108
Query: 316 --ILLCEISTLTE----------------LNLSCNGFHD-----LPSQIGNLLNLQTLCL 352
I C+ T+ E LNL+ +D LP+ G L+ L+ L L
Sbjct: 109 ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILEL 168
Query: 353 DGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLN 412
N L TLP+ + L QL L + N F ++PEV +++ L + M N L+VL G +
Sbjct: 169 RENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP-GSIG 227
Query: 413 RMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQL 472
++ + ++D+ N ++T+ D+D+S +LE L N L
Sbjct: 228 KLKMLVYLDMSKNRIETV----------------------DMDISGCEALEDLLLSSNML 265
Query: 473 RELTLS-GF--SLRTLYASSNRLTAV-NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIE 528
++L S G L TL N+LT + N SLL D S N LE +P +
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
Query: 529 VLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRLPD 587
L V N L E+P I S ++ + L N ++ LP + + L VL+L N L LP
Sbjct: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
Query: 588 TLFSKALNLRYLNASANSLESL 609
+ F+K L L S N ++L
Sbjct: 386 S-FTKLKELAALWLSDNQSKAL 406
Score = 100 bits (248), Expect = 1e-20
Identities = 84/285 (29%), Positives = 141/285 (49%), Gaps = 20/285 (7%)
Query: 503 LLTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQ 561
+++ LD S L+ VP ++ +E L + N + E+P ++ + +LRKL + N +
Sbjct: 23 IISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLS 82
Query: 562 NLPTLVEH-IPLEVLDLQHNALTRLPDTL-FSKALNLRYLNASANSLESLPSACTGEESL 619
NLPT + + L+ LD+ N + P+ + K L + + AS N + LP T
Sbjct: 83 NLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNPISKLPDGFT----- 135
Query: 620 SMLQLLYLTNNLLTD---QCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNL 675
QLL LT L D + +P G L LRIL L N L+T P S ++KL QLE L+L
Sbjct: 136 ---QLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS-MHKLAQLERLDL 191
Query: 676 SGNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEILIPEAL 734
N+ +P + + L L +N + + P I +L + ++D+S N + + + +
Sbjct: 192 GNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISG 251
Query: 735 PATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTV 779
L+DL L+ N L ++ + +TTLK+D L +T+
Sbjct: 252 CEALEDLLLSSNMLQQLPD-SIGLLKKLTTLKVDDNQLTMLPNTI 295
Score = 92.0 bits (227), Expect = 3e-18
Identities = 81/286 (28%), Positives = 145/286 (50%), Gaps = 22/286 (7%)
Query: 461 SLEQLHCGRNQLRELTLSGFS---LRTLYASSNRLTAVNVYPVPSLLTF--LDLSRNLLE 515
+LE+L+ NQ+ EL F+ LR L N L+ + + SL+ LD+S+N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT-TIASLVNLKELDISKNGVQ 105
Query: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEH-IPLEV 574
P+ K + +++ S N ++++P L+L +L L ++ LP + L +
Sbjct: 106 EFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRI 165
Query: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634
L+L+ N L LP ++ K L L+ N LP + + L+ L++ NN L
Sbjct: 166 LELRENHLKTLPKSMH-KLAQLERLDLGNNEFGELPEVL---DQIQNLRELWMDNNAL-- 219
Query: 635 QCIPVLVGHLHLRI-LHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRL 693
Q +P +G L + + L ++ N+++T ++ E LE+L LS N L+ +P +I K+L
Sbjct: 220 QVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSSNMLQQLPDSIGLLKKL 278
Query: 694 HTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATL 738
TL N +++ P + L ++ D SCN+L E+LP+T+
Sbjct: 279 TTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNEL------ESLPSTI 318
Score = 80.9 bits (198), Expect = 8e-15
Identities = 87/305 (28%), Positives = 148/305 (48%), Gaps = 28/305 (9%)
Query: 444 VDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVP 501
+ + DN L++L ++SL +L++L +N ++E + + L + +V P+
Sbjct: 74 LSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCL-----TIIEASVNPIS 128
Query: 502 SL---------LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRK 552
L LT L L+ LE +P K+ +L++ N L +P + L +
Sbjct: 129 KLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLER 188
Query: 553 LMLGHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPS 611
L LG+N LP +++ I L L + +NAL LP ++ K L YL+ S N +E++
Sbjct: 189 LDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSI-GKLKMLVYLDMSKNRIETVDM 247
Query: 612 ACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKLEQL 670
+G E+L + L L++N+L Q +P +G L L L + +NQL P + + L L
Sbjct: 248 DISGCEAL---EDLLLSSNML--QQLPDSIGLLKKLTTLKVDDNQLTMLP-NTIGNLSLL 301
Query: 671 EELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEIL 729
EE + S N+L+++P+TI L TL N + P EI + + L N L
Sbjct: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE--F 359
Query: 730 IPEAL 734
+PE +
Sbjct: 360 LPEEI 364
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 111 bits (277), Expect = 5e-24
Identities = 115/366 (31%), Positives = 168/366 (45%), Gaps = 40/366 (10%)
Query: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
+L EL L N +LP LLNL+ L L N + LP E+ N QL L +S N+ +
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN-KHI 441
IPE + L+ +GN L L G ++ + H L +N + + GN ++
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDG-FTQLRSLAH--LALNDVSLQALPGDVGNLANL 153
Query: 442 THVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL--TLSGF-SLRTLYASSNRLTAV- 495
++LR+N L L LS L LEQL G N L L TL +LR L+ N+L+A+
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
Query: 496 -----------------NVYPVPS------LLTFLDLSRNLLECVPDWACEAKKIEVLDV 532
+ +P+ LLT L LS+NLL +PD + K++ +L V
Sbjct: 214 PELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKV 273
Query: 533 SYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP-TLVEHIPLEVLDLQHNALTRLPDTLFS 591
N L EV I +L +L+L N + LP +L + L L++ N L LP +
Sbjct: 274 DQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI-G 332
Query: 592 KALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHL 651
+ L L+ N L LP L +L + N L Q +P + HL+L+ L L
Sbjct: 333 GCVALSVLSLRDNRLAVLPPELAHTTELHVLD---VAGNRL--QSLPFALTHLNLKALWL 387
Query: 652 ANNQLQ 657
A NQ Q
Sbjct: 388 AENQAQ 393
Score = 93.6 bits (231), Expect = 1e-18
Identities = 93/294 (31%), Positives = 139/294 (47%), Gaps = 50/294 (17%)
Query: 513 LLECVPDWACE-----------------------AKKIEVLDVSYNLLTEVPVRILSSLS 549
+L+C+P W C ++ +E L + N L E+P L+
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTL-FSKALNLRYLNASANSLE 607
LRKL L N +Q LP V + + L LD+ N + +P+++ F KAL + + S N L
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIA--DFSGNPLS 118
Query: 608 SLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNK 666
LP T SL+ L L N ++ Q +P VG+L +L L L N L++ PAS L+
Sbjct: 119 RLPDGFTQLRSLAHLAL-----NDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172
Query: 667 LEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIF-PEILQLPQIQFVDLSCNDL 725
L +LE+L+L GN L+ +P T+ L L N +S PE+ L ++ +D+S N L
Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232
Query: 726 TEILIPEALPATLQDLDLTGNTNLVLEHKTL-------DIFSHITTLKIDQKPL 772
E LPA L L L T+L+L L ++ LK+DQ L
Sbjct: 233 ------EELPAELGGLVLL--TDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 89.4 bits (220), Expect = 2e-17
Identities = 89/330 (26%), Positives = 137/330 (41%), Gaps = 46/330 (13%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
+ D S L +P+ + + +L L +Q PG + L + L L L N
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA-LPGDVGNL---ANLVTLELRENL 162
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
L P L + L +L+L N LP +G L NL+ L LD N L+ LP ELGNL++L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
L +S N ++P L +L ++++ N L L G+ LK +
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI--------------GQLKQL 268
Query: 431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSN 490
I ++ N+ LC + + L EL L+ L L S
Sbjct: 269 SILKVDQNR-------------------LCEVTEAIGDCENLSELILTENLLMALPRSLG 309
Query: 491 RLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSL 550
+LT LT L++ RN LE +P + VL + N L +P + + L
Sbjct: 310 KLTK---------LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 551 RKLMLGHNHVQNLPTLVEHIPLEVLDLQHN 580
L + N +Q+LP + H+ L+ L L N
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAEN 390
Score = 78.6 bits (192), Expect = 4e-14
Identities = 96/331 (29%), Positives = 147/331 (44%), Gaps = 47/331 (14%)
Query: 438 NKHITHVDLRDNRLTDLDLSSLC---SLEQLHCGRNQLRELTLSGF---SLRTLYASSNR 491
N+H+ VD R L + SLE+L NQLREL F +LR L S N
Sbjct: 11 NRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE 70
Query: 492 LTAVNVYPVPSLLTF-----LDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILS 546
+ + P + F LD+SRN + +P+ K +E+ D S N L+ +P
Sbjct: 71 IQRLP----PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ 126
Query: 547 SLSLRKLMLGHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANS 605
SL L L +Q LP V ++ L L+L+ N L LP +L S + L L+ N
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGND 185
Query: 606 LESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASK- 663
LE LP +L L+ L+L N L+ +P +G+L L L ++ N+L+ PA
Sbjct: 186 LEVLPDTLG---ALPNLRELWLDRNQLS--ALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 664 ---------------------LNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNN 702
+ +L+QL L + N+L + I +C+ L L+ N
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 703 ISIFPEIL-QLPQIQFVDLSCNDLTEILIPE 732
+ P L +L ++ +++ N L E L PE
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHL-EALPPE 330
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 111 bits (277), Expect = 5e-24
Identities = 115/366 (31%), Positives = 168/366 (45%), Gaps = 40/366 (10%)
Query: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
+L EL L N +LP LLNL+ L L N + LP E+ N QL L +S N+ +
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN-KHI 441
IPE + L+ +GN L L G ++ + H L +N + + GN ++
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDG-FTQLRSLAH--LALNDVSLQALPGDVGNLANL 153
Query: 442 THVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL--TLSGF-SLRTLYASSNRLTAV- 495
++LR+N L L LS L LEQL G N L L TL +LR L+ N+L+A+
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
Query: 496 -----------------NVYPVPS------LLTFLDLSRNLLECVPDWACEAKKIEVLDV 532
+ +P+ LLT L LS+NLL +PD + K++ +L V
Sbjct: 214 PELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKV 273
Query: 533 SYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP-TLVEHIPLEVLDLQHNALTRLPDTLFS 591
N L EV I +L +L+L N + LP +L + L L++ N L LP +
Sbjct: 274 DQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI-G 332
Query: 592 KALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHL 651
+ L L+ N L LP L +L + N L Q +P + HL+L+ L L
Sbjct: 333 GCVALSVLSLRDNRLAVLPPELAHTTELHVLD---VAGNRL--QSLPFALTHLNLKALWL 387
Query: 652 ANNQLQ 657
A NQ Q
Sbjct: 388 AENQAQ 393
Score = 93.6 bits (231), Expect = 1e-18
Identities = 93/294 (31%), Positives = 139/294 (47%), Gaps = 50/294 (17%)
Query: 513 LLECVPDWACE-----------------------AKKIEVLDVSYNLLTEVPVRILSSLS 549
+L+C+P W C ++ +E L + N L E+P L+
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTL-FSKALNLRYLNASANSLE 607
LRKL L N +Q LP V + + L LD+ N + +P+++ F KAL + + S N L
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIA--DFSGNPLS 118
Query: 608 SLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNK 666
LP T SL+ L L N ++ Q +P VG+L +L L L N L++ PAS L+
Sbjct: 119 RLPDGFTQLRSLAHLAL-----NDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172
Query: 667 LEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIF-PEILQLPQIQFVDLSCNDL 725
L +LE+L+L GN L+ +P T+ L L N +S PE+ L ++ +D+S N L
Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232
Query: 726 TEILIPEALPATLQDLDLTGNTNLVLEHKTL-------DIFSHITTLKIDQKPL 772
E LPA L L L T+L+L L ++ LK+DQ L
Sbjct: 233 ------EELPAELGGLVLL--TDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Score = 89.4 bits (220), Expect = 2e-17
Identities = 89/330 (26%), Positives = 137/330 (41%), Gaps = 46/330 (13%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
+ D S L +P+ + + +L L +Q PG + L + L L L N
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA-LPGDVGNL---ANLVTLELRENL 162
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
L P L + L +L+L N LP +G L NL+ L LD N L+ LP ELGNL++L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
L +S N ++P L +L ++++ N L L G+ LK +
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI--------------GQLKQL 268
Query: 431 VIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSN 490
I ++ N+ LC + + L EL L+ L L S
Sbjct: 269 SILKVDQNR-------------------LCEVTEAIGDCENLSELILTENLLMALPRSLG 309
Query: 491 RLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSL 550
+LT LT L++ RN LE +P + VL + N L +P + + L
Sbjct: 310 KLTK---------LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 551 RKLMLGHNHVQNLPTLVEHIPLEVLDLQHN 580
L + N +Q+LP + H+ L+ L L N
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAEN 390
Score = 78.6 bits (192), Expect = 4e-14
Identities = 96/331 (29%), Positives = 147/331 (44%), Gaps = 47/331 (14%)
Query: 438 NKHITHVDLRDNRLTDLDLSSLC---SLEQLHCGRNQLRELTLSGF---SLRTLYASSNR 491
N+H+ VD R L + SLE+L NQLREL F +LR L S N
Sbjct: 11 NRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE 70
Query: 492 LTAVNVYPVPSLLTF-----LDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILS 546
+ + P + F LD+SRN + +P+ K +E+ D S N L+ +P
Sbjct: 71 IQRLP----PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ 126
Query: 547 SLSLRKLMLGHNHVQNLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANS 605
SL L L +Q LP V ++ L L+L+ N L LP +L S + L L+ N
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGND 185
Query: 606 LESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASK- 663
LE LP +L L+ L+L N L+ +P +G+L L L ++ N+L+ PA
Sbjct: 186 LEVLPDTLG---ALPNLRELWLDRNQLS--ALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 664 ---------------------LNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNN 702
+ +L+QL L + N+L + I +C+ L L+ N
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 703 ISIFPEIL-QLPQIQFVDLSCNDLTEILIPE 732
+ P L +L ++ +++ N L E L PE
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHL-EALPPE 330
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 110 bits (276), Expect = 7e-24
Identities = 100/322 (31%), Positives = 151/322 (46%), Gaps = 38/322 (11%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
+ D S L +PE Q++T L++ +Q P + LY L L L N
Sbjct: 107 LQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ-SLPENIGNLYN---LASLELRENL 162
Query: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
L P L ++ L EL+L N ++LP IG LL+L+ L LDGN L+ LP+E+GNL+ L
Sbjct: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
Query: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVL--NLGVLNRMNHIKHVDLRMNHLK 428
L +S N ++PE LT L +V++ N LE + +G L +++ +K R+ L
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLP 282
Query: 429 TMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL--TLSG-FSLR 483
V E + +T + L +N+L L + L L L+ RN+L L + G SL
Sbjct: 283 EAVGE----CESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLT 338
Query: 484 TLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVR 543
NRLT +P +A ++ VLDV+ N L +P+
Sbjct: 339 VFCVRDNRLTR----------------------IPAEVSQATELHVLDVAGNRLLHLPLS 376
Query: 544 ILSSLSLRKLMLGHNHVQNLPT 565
L++L L+ L L N Q L T
Sbjct: 377 -LTALKLKALWLSDNQSQPLLT 397
Score = 110 bits (275), Expect = 9e-24
Identities = 115/419 (27%), Positives = 195/419 (46%), Gaps = 45/419 (10%)
Query: 248 SQRISTVDLSCYSLEEVPEHLF-YSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNL 306
++ + ++D SL VPE ++ Y++ + L L N ++ E P + ++ +L+ L L
Sbjct: 11 NRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLR-ELP---EQFFQLVKLRKLGL 66
Query: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGN 366
S N++ P + L EL++S N ++P I LQ GN LT LPE
Sbjct: 67 SDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPE 126
Query: 367 LQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNH 426
LQ L+ L ++ + +PE N+G + ++ ++LR N
Sbjct: 127 LQNLTCLSVNDISLQSLPE---------------------NIG---NLYNLASLELREN- 161
Query: 427 LKTMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLSGFSLRT 484
L T + ++L + + +DL +N + +L + +L L+ L NQL EL +L+
Sbjct: 162 LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKN 221
Query: 485 LY---ASSNRLTAV--NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTE 539
L S NRL + + + S LT L +S+NLLE +PD + KK+ +L V N LT+
Sbjct: 222 LLCLDVSENRLERLPEEISGLTS-LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ 280
Query: 540 VPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRLPDTLFSKALNLRY 598
+P + SL +L+L N + LP + + L L+ N L LP + +L
Sbjct: 281 LPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI-GGCCSLTV 339
Query: 599 LNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQ 657
N L +P+ + L +L + N LL +P+ + L L+ L L++NQ Q
Sbjct: 340 FCVRDNRLTRIPAEVSQATELHVLDV--AGNRLLH---LPLSLTALKLKALWLSDNQSQ 393
Score = 95.9 bits (237), Expect = 2e-19
Identities = 119/440 (27%), Positives = 186/440 (42%), Gaps = 80/440 (18%)
Query: 346 NLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEV 405
+L+ L LD N L LPE+ L +L LG+S N ++P N +++
Sbjct: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEI------------ANFMQL 84
Query: 406 LNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQL 465
+ L V N I + ++ K + + + G N LT L S L+ L
Sbjct: 85 VELDVSR--NEIPEIPESISFCKALQVADFSG-----------NPLTRLP-ESFPELQNL 130
Query: 466 HCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAK 525
C L+++ SL++L + N+Y + SL +L NLL +PD + +
Sbjct: 131 TC-------LSVNDISLQSLPENIG-----NLYNLASL----ELRENLLTYLPDSLTQLR 174
Query: 526 KIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRL 585
++E LD+ N + +P I + L L+ L L N + LP + ++
Sbjct: 175 RLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLK-------------- 220
Query: 586 PDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH 645
NL L+ S N LE LP +G L+ L L ++ NLL + IP +G L
Sbjct: 221 ---------NLLCLDVSENRLERLPEEISG---LTSLTDLVISQNLL--ETIPDGIGKLK 266
Query: 646 -LRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS 704
L IL + N+L P + + + E L EL L+ N+L T+P +I K+L L A N +
Sbjct: 267 KLSILKVDQNRLTQLPEA-VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLV 325
Query: 705 IFP-EILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHIT 763
P EI + + N LT I + L LD+ GN + L + +T
Sbjct: 326 SLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGN-------RLLHLPLSLT 378
Query: 764 TLKIDQKPLPTTDSTVTSTF 783
LK+ L S TF
Sbjct: 379 ALKLKALWLSDNQSQPLLTF 398
Score = 85.9 bits (211), Expect = 2e-16
Identities = 84/294 (28%), Positives = 132/294 (44%), Gaps = 50/294 (17%)
Query: 513 LLECVPDWACE-----------------------AKKIEVLDVSYNLLTEVPVRILSSLS 549
+ C+P W C A+ +E L + N L E+P + +
Sbjct: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
Query: 550 LRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLPDTL-FSKALNLRYLNASANSLE 607
LRKL L N +Q LP + + L LD+ N + +P+++ F KAL + + S N L
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVA--DFSGNPLT 118
Query: 608 SLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNK 666
LP + ++L+ L + N ++ Q +P +G+L+ L L L N L P S L +
Sbjct: 119 RLPESFPELQNLTCLSV-----NDISLQSLPENIGNLYNLASLELRENLLTYLPDS-LTQ 172
Query: 667 LEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDL 725
L +LEEL+L N++ +P +I L L N +S P EI L + +D+S N L
Sbjct: 173 LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
Query: 726 TEILIPEALPATLQDLDLTGNTNLVLEHKTLDI-------FSHITTLKIDQKPL 772
E LP + LT T+LV+ L+ ++ LK+DQ L
Sbjct: 233 ------ERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRL 278
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 105 bits (261), Expect = 4e-22
Identities = 114/455 (25%), Positives = 216/455 (47%), Gaps = 34/455 (7%)
Query: 337 LPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRV 396
+P +I L+ + L+ N + +P+E+ L+ + L + NN + L+ L+ +
Sbjct: 40 IPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESL 99
Query: 397 VMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDL-- 454
++ N + +L V++ ++ ++ + L LK + + + H+ + L N L L
Sbjct: 100 DLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPK 159
Query: 455 DLSSLCSLEQLHCGRNQL----RELTLSGFSLRTLYASSNRLTAV--NVYPVPSLLTFLD 508
++ + L +++ RNQ +EL + ++L + N++ A+ + + L F
Sbjct: 160 EIVNQTKLREIYLKRNQFEVFPQELCVL-YTLEIIDLDENKIGAIPEEIGHLTGLQKFYM 218
Query: 509 LSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLV- 567
S N L +P C+ ++ VLD+S+NLL +P + ++ L N ++ +P L+
Sbjct: 219 ASNN-LPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
Query: 568 EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP-SACTGEESLSMLQLLY 626
L +L L + L RL + F +NLR+L+ S N L P C +L L++L
Sbjct: 278 RWTSLHLLYLGNTGLHRLRGS-FRCLVNLRFLDLSQNHLHHCPLQIC----ALKNLEVLG 332
Query: 627 LTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNL---SGNKLKT 682
L +N + +P +G L L+IL L N+ +FP L+ L LE+L + G KL
Sbjct: 333 LDDNKIGQ--LPSELGSLSKLKILGLTGNEFLSFPEEVLS-LASLEKLYIGQDQGFKLTY 389
Query: 683 IPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEAL--PATLQ 739
+P I + L L +N++ P L +P ++ +D N L + +P+A+ L+
Sbjct: 390 VPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQ--LPDAICQAQALK 447
Query: 740 DLDLTGNTNLVLEH--KTLDIFSHITTLKIDQKPL 772
+L L N +L H + LD ++ L + P+
Sbjct: 448 ELRLEDN---LLTHLPENLDSLVNLKVLTLMDNPM 479
Score = 99.8 bits (247), Expect = 2e-20
Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 55/320 (17%)
Query: 299 SQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLT 358
++L+ + L N+ +FP LC + TL ++L N +P +IG+L LQ + N L
Sbjct: 165 TKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLP 224
Query: 359 TLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLE-------------- 404
LP L QLS L +S N IP+ + +L + + ++GN LE
Sbjct: 225 VLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL 284
Query: 405 -----------------VLNLGVLN-RMNHIKHVDLRMNHLKTMVIENLEGNK------- 439
++NL L+ NH+ H L++ LK + + L+ NK
Sbjct: 285 LYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSE 344
Query: 440 -----HITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTL------SGFSLRTLY 486
+ + L N ++ SL SLE+L+ G++Q +LT SL+ LY
Sbjct: 345 LGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELY 404
Query: 487 ASSNRL--TAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRI 544
+N L V++ +P+ L LD NLL+ +PD C+A+ ++ L + NLLT +P +
Sbjct: 405 IENNHLEYLPVSLGSMPN-LEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
Query: 545 LSSLSLRKLMLGHNHVQNLP 564
S ++L+ L L N ++ P
Sbjct: 464 DSLVNLKVLTLMDNPMEEPP 483
Score = 94.0 bits (232), Expect = 9e-19
Identities = 135/493 (27%), Positives = 202/493 (40%), Gaps = 97/493 (19%)
Query: 240 QRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ-----LERPGGLDT 294
QR + V+ R +D S SL +P +F ++ ++L +N ++ ++R +
Sbjct: 16 QRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRV 75
Query: 295 LYK--------------FSQLKGLNLSHN-----------------KLGLFPILLCEIST 323
LY S L+ L+LS+N +L L+ L EI
Sbjct: 76 LYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPV 135
Query: 324 --------LTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGI 375
L L L+ N LP +I N L+ + L N P+EL L L + +
Sbjct: 136 VIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDL 195
Query: 376 SFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENL 435
N IPE LT L + MA N L VL L + + + +DL N L ++
Sbjct: 196 DENKIGAIPEEIGHLTGLQKFYMASNNLPVLPAS-LCQCSQLSVLDLSHNLLHSIPKSFA 254
Query: 436 EGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAV 495
E K +T + L NRL + +L C L L L L L S L V
Sbjct: 255 ELRK-MTEIGLSGNRLE--------KVPRLICRWTSLHLLYLGNTGLHRLRGSFRCL--V 303
Query: 496 NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV--------------- 540
N L FLDLS+N L P C K +EVL + N + ++
Sbjct: 304 N-------LRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGL 356
Query: 541 --------PVRILSSLSLRKLMLGHNHVQNLPTLVEHI----PLEVLDLQHNALTRLPDT 588
P +LS SL KL +G + L + EHI L+ L +++N L LP +
Sbjct: 357 TGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVS 416
Query: 589 LFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL-HLR 647
L S NL L+ N L+ LP A ++L L+ L +NLLT +P + L +L+
Sbjct: 417 LGSMP-NLEVLDCRHNLLKQLPDAICQAQALKELR---LEDNLLTH--LPENLDSLVNLK 470
Query: 648 ILHLANNQLQTFP 660
+L L +N ++ P
Sbjct: 471 VLTLMDNPMEEPP 483
Score = 82.0 bits (201), Expect = 3e-15
Identities = 74/244 (30%), Positives = 116/244 (47%), Gaps = 8/244 (3%)
Query: 506 FLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL-P 564
F+D S L +P ++E + + N + E+P I ++R L L N++++L P
Sbjct: 29 FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 565 TLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQL 624
L LE LDL +N + + S LR L L+ +P ++L L+L
Sbjct: 89 ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIF--KNLHHLEL 146
Query: 625 LYLTNNLLTDQCIP-VLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTI 683
L LT N L +C+P +V LR ++L NQ + FP +L L LE ++L NK+ I
Sbjct: 147 LGLTGNHL--KCLPKEIVNQTKLREIYLKRNQFEVFP-QELCVLYTLEIIDLDENKIGAI 203
Query: 684 PTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDLTEILIPEALPATLQDLD 742
P I + L SNN+ + P + Q Q+ +DLS N L I A + ++
Sbjct: 204 PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIG 263
Query: 743 LTGN 746
L+GN
Sbjct: 264 LSGN 267
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 259 YSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILL 318
+ L VPEH+ Q + L + +N ++ P L ++ L+ L+ HN L P +
Sbjct: 385 FKLTYVPEHIRKLQSLKELYIENNHLEY-LPVSLGSM---PNLEVLDCRHNLLKQLPDAI 440
Query: 319 CEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEEL 364
C+ L EL L N LP + +L+NL+ L L N + P+E+
Sbjct: 441 CQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/89 (32%), Positives = 40/89 (44%)
Query: 297 KFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNF 356
K LK L + +N L P+ L + L L+ N LP I L+ L L+ N
Sbjct: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
Query: 357 LTTLPEELGNLQQLSSLGISFNNFSQIPE 385
LT LPE L +L L L + N + P+
Sbjct: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 97.8 bits (242), Expect = 6e-20
Identities = 125/439 (28%), Positives = 198/439 (45%), Gaps = 75/439 (17%)
Query: 327 LNLSCNGFHD--LPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIP 384
++LS N F P + + +L+ L L+ L LPEEL LQ+L L +S NN + +
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
Query: 385 EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHV 444
L L +V N L+ N GV + + + + + +
Sbjct: 73 GELSSLPSLRAIVARANSLK--NSGVPDDIFKLDDLSV---------------------L 109
Query: 445 DLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLL 504
DL N+LT+ +L +N L L LS S+ T+ N+L +N+ L
Sbjct: 110 DLSHNQLTECP-------RELENAKNML-VLNLSHNSIDTI---PNQLF-INLTD----L 153
Query: 505 TFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNH--VQ 561
+LDLS N LE +P ++ L ++ N L +R L +++ L+ L L
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213
Query: 562 NLPTLVEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLS 620
NLPT +E + L +DL N LTR+P+ L++ +LR LN S+N + L S C +
Sbjct: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLP-SLRRLNLSSNQITEL-SLCI--DQWV 269
Query: 621 MLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPA-SKLNKLEQLEELNLSGN 678
++ L L+ N LT +P + L L+ L+L +N+L S + KL LEE + N
Sbjct: 270 HVETLNLSRNQLTS--LPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN 327
Query: 679 KLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATL 738
L+ +P ++ C +L LV + N++ PE + LTEI +
Sbjct: 328 NLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHF------------LTEIEV-------- 367
Query: 739 QDLDLTGNTNLVLEHKTLD 757
LD+ N NLV+ K D
Sbjct: 368 --LDVRENPNLVMPPKPAD 384
Score = 90.9 bits (224), Expect = 7e-18
Identities = 99/361 (27%), Positives = 157/361 (43%), Gaps = 59/361 (16%)
Query: 258 CYSLEEVPEHLFYSQDITYLNLRHNFM---------------------QLERPGGLDTLY 296
CY +PE L Q + +L++ HN + L+ G D ++
Sbjct: 46 CY----LPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIF 101
Query: 297 KFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNF 356
K L L+LSHN+L + P ++ N N+ L L N
Sbjct: 102 KLDDLSVLDLSHNQL-----------------------TECPRELENAKNMLVLNLSHNS 138
Query: 357 LTTLPEELG-NLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMN 415
+ T+P +L NL L L +S N +P +L L +V+ GN L L L M
Sbjct: 139 IDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMT 198
Query: 416 HIKHVDLR-MNHLKTMVIENLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQL 472
++ + LR ++ + +LEG ++ VDL N LT + L +L SL +L+ NQ+
Sbjct: 199 ALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQI 258
Query: 473 RELTL---SGFSLRTLYASSNRLTAV-NVYPVPSLLTFLDLSRNLLEC--VPDWACEAKK 526
EL+L + TL S N+LT++ + S L L L+ N L+ +P +
Sbjct: 259 TELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTN 318
Query: 527 IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRL 585
+E + N L VP + LRKL+L NH+ LP + + +EVLD++ N +
Sbjct: 319 LEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVM 378
Query: 586 P 586
P
Sbjct: 379 P 379
Score = 69.3 bits (168), Expect = 2e-11
Identities = 50/146 (34%), Positives = 75/146 (51%), Gaps = 6/146 (4%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
++ VDLSC L VPE L+ + LNL N + E +D ++ ++ LNLS N+
Sbjct: 225 LADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQI-TELSLCID---QWVHVETLNLSRNQ 280
Query: 311 LGLFPILLCEISTLTELNLSCN--GFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368
L P +C++S L +L L+ N F LPS IG L NL+ N L +PE L
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
Query: 369 QLSSLGISFNNFSQIPEVYEKLTMLD 394
+L L ++ N+ +PE LT ++
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIE 366
Score = 32.7 bits (73), Expect = 2.4
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 4/112 (3%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLER-PGGLDTLYKFSQLKGLNLSHN 309
+ T++LS L +P + + L L N + + P G+ K + L+ ++N
Sbjct: 271 VETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG---KLTNLEEFMAANN 327
Query: 310 KLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLP 361
L L P LC L +L L+ N LP I L ++ L + N +P
Sbjct: 328 NLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 97.1 bits (240), Expect = 1e-19
Identities = 99/310 (31%), Positives = 147/310 (47%), Gaps = 16/310 (5%)
Query: 393 LDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLT 452
++ + + N LE + G+ + + ++ + LR N + E H+T +D+ NRLT
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 453 DLD---LSSLCSLEQLHCGRNQLRELT--LSGFS-LRTLYASSNRLTAV-NVYPVPSLLT 505
L +S+L L +L+ NQL L L + L L S NRL + + S L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 506 FLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPT 565
LD+ N L P + +E LDVS N L +P I + +L+ L L + LP
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 566 -LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQL 624
E LE L L +N L LP FS L+ LN S+N E P+A L+ L+
Sbjct: 245 GFCELASLESLMLDNNGLQALP-AQFSCLQRLKMLNLSSNLFEEFPAALL---PLAGLEE 300
Query: 625 LYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTI 683
LYL+ N LT +P L+ L L L L NN+++ P S + +L LEEL L GN++ +
Sbjct: 301 LYLSRNQLTS--VPSLISGLGRLLTLWLDNNRIRYLPDS-IVELTGLEELVLQGNQIAVL 357
Query: 684 PTTIANCKRL 693
P R+
Sbjct: 358 PDHFGQLSRV 367
Score = 82.0 bits (201), Expect = 3e-15
Identities = 85/314 (27%), Positives = 142/314 (45%), Gaps = 31/314 (9%)
Query: 316 ILLCEISTLTELNLSCNGFHDLPSQIGNLL-NLQTLCLDGNFLTTLPEELGNL-QQLSSL 373
+L + + LNL NG ++P +G+ L +L+ L L N LP + L L+ L
Sbjct: 57 VLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTEL 116
Query: 374 GISFNNFSQI-PEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVI 432
+S N + + EV L L ++ ++ N L L L + H++ +D+ N L +
Sbjct: 117 DVSHNRLTALGAEVVSALRELRKLNLSHNQLPALP-AQLGALAHLEELDVSFNRLAHLP- 174
Query: 433 ENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELT-------------L 477
++L + +D+ N+LT L L +LE+L N+LR L L
Sbjct: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
Query: 478 SGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537
SG L TL A L + L L L N L+ +P +++++L++S NL
Sbjct: 235 SGAELGTLPAGFCELAS---------LESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285
Query: 538 TEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRLPDTLFSKALNL 596
E P +L L +L L N + ++P+L+ + L L L +N + LPD++ + L
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV-ELTGL 344
Query: 597 RYLNASANSLESLP 610
L N + LP
Sbjct: 345 EELVLQGNQIAVLP 358
Score = 77.4 bits (189), Expect = 8e-14
Identities = 76/277 (27%), Positives = 128/277 (46%), Gaps = 11/277 (3%)
Query: 274 ITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNG 333
+T L++ HN + G + + +L+ LNLSHN+L P L ++ L EL++S N
Sbjct: 113 LTELDVSHNRLTAL---GAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNR 169
Query: 334 FHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTML 393
LP + L L+TL +D N LT P +L L L L +S N +PE L L
Sbjct: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229
Query: 394 DRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTD 453
+ ++G L L G + ++ + L N L+ + + + + ++L N +
Sbjct: 230 KILWLSGAELGTLPAGFC-ELASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEE 287
Query: 454 LD--LSSLCSLEQLHCGRNQLREL--TLSGFS-LRTLYASSNRLTAVNVYPVP-SLLTFL 507
L L LE+L+ RNQL + +SG L TL+ +NR+ + V + L L
Sbjct: 288 FPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEEL 347
Query: 508 DLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRI 544
L N + +PD + ++ + + N L + P +
Sbjct: 348 VLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 54.3 bits (129), Expect = 8e-07
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 7/155 (4%)
Query: 595 NLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL--HLRILHLA 652
++ LN N LE +P +L L++L L N +P V L HL L ++
Sbjct: 64 DIEALNLGNNGLEEVPEGLGS--ALGSLRVLVLRRNRFAR--LPPAVAELGHHLTELDVS 119
Query: 653 NNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQ- 711
+N+L A ++ L +L +LNLS N+L +P + L L N ++ P+ L
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 712 LPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGN 746
L +++ +D+ N LT L++LD++ N
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSN 214
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 95.1 bits (235), Expect = 4e-19
Identities = 122/424 (28%), Positives = 192/424 (45%), Gaps = 53/424 (12%)
Query: 289 PGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQ-IGNLLNL 347
PG LD L + L NL+ + GLF + L EL LS N +P Q L +L
Sbjct: 61 PGDLDPLTAYLDLSMNNLTELQPGLFH----HLRFLEELRLSGNHLSHIPGQAFSGLYSL 116
Query: 348 QTLCLDGNFLTTLPEE-LGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCLEV 405
+ L L N L +P E L L L SL + N S +PE +E L+ L + + N L
Sbjct: 117 KILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE 176
Query: 406 LNLGVLNRM----------NHIKHV-DLRMNHLKTMVIENLEGNK--HI-TH-------- 443
+ + LN + N I H+ D +L ++V+ +L N+ H+ TH
Sbjct: 177 IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNL 236
Query: 444 --VDLRDNRLTDLDLS--SLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLTAV 495
+DL N+L + ++ +L L++L N ++ + F L+T++ N + V
Sbjct: 237 ETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV 296
Query: 496 NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSS------LS 549
L LS N + ++ + K L++ LT +R+L S
Sbjct: 297 GRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEIL--TLTRAGIRLLPSGMCQQLPR 353
Query: 550 LRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESL 609
LR L L HN ++ LP+L LE + LQHN + + FS+ +L+ L+ S N++ S+
Sbjct: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413
Query: 610 -PSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRIL-HLANNQLQTFPASKLNKL 667
P A + +L L L LT+N LT + L G +HL++ +LA + Q F KL
Sbjct: 414 HPEAFS---TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS--QAFSKDSFPKL 468
Query: 668 EQLE 671
LE
Sbjct: 469 RILE 472
Score = 84.0 bits (206), Expect = 9e-16
Identities = 69/210 (32%), Positives = 100/210 (47%), Gaps = 6/210 (2%)
Query: 503 LLTFLDLS-RNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSL-SLRKLMLGHNHV 560
L +LDLS NL E P + +E L +S N L+ +P + S L SL+ LML +N +
Sbjct: 67 LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 126
Query: 561 QNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEES 618
+P L E L+ L L N ++ +P+ F +LR+L N+L +P +
Sbjct: 127 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALN--N 184
Query: 619 LSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGN 678
L LQ + L N ++ L +LHL NN++Q L LE L+L+ N
Sbjct: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYN 244
Query: 679 KLKTIPTTIANCKRLHTLVAHSNNISIFPE 708
KL+ P I RL L H+NNI PE
Sbjct: 245 KLQEFPVAIRTLGRLQELGFHNNNIKAIPE 274
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 93.2 bits (230), Expect = 1e-18
Identities = 128/444 (28%), Positives = 202/444 (45%), Gaps = 54/444 (12%)
Query: 247 VSQRISTVDLSCYSLEEVPEHLFYS-QDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLN 305
VS IS DLS +L E+ LF+ + + L L N + LY LK L
Sbjct: 12 VSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS---LKILM 68
Query: 306 LSHNKLGLFPI-LLCEISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNFLTTLP-E 362
L +N+LG P L E+ +L L L N +P + L +L+ L LD N LT +P
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 128
Query: 363 ELGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVD 421
L NL L ++ ++ N S IP+ ++ LT +L VL+ N+
Sbjct: 129 ALNNLPALQAMTLALNRISHIPDYAFQNLT---------------SLVVLHLHNN----- 168
Query: 422 LRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLS--SLCSLEQLHCGRNQLRELTLSG 479
R+ HL T + EG ++ +DL N+L + ++ +L L++L N ++ +
Sbjct: 169 -RIQHLGT---HSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 224
Query: 480 FS----LRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYN 535
F L+T++ N + V L LS N + ++ + K L++
Sbjct: 225 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-DLKGTTSLEIL-- 281
Query: 536 LLTEVPVRILSS------LSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTL 589
LT +R+L S LR L L HN ++ LP+L LE + LQHN + +
Sbjct: 282 TLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADT 341
Query: 590 FSKALNLRYLNASANSLESL-PSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRI 648
FS+ +L+ L+ S N++ S+ P A + +L L L LT+N LT + L G +HL++
Sbjct: 342 FSQLSSLQALDLSWNAIRSIHPEAFS---TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398
Query: 649 L-HLANNQLQTFPASKLNKLEQLE 671
+LA + Q F KL LE
Sbjct: 399 KGNLALS--QAFSKDSFPKLRILE 420
Score = 81.3 bits (199), Expect = 6e-15
Identities = 69/216 (31%), Positives = 102/216 (47%), Gaps = 6/216 (2%)
Query: 497 VYPVPSLLTFLDLS-RNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSL-SLRKLM 554
V V +++ DLS NL E P + +E L +S N L+ +P + S L SL+ LM
Sbjct: 9 VCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 68
Query: 555 LGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSA 612
L +N + +P L E L+ L L N ++ +P+ F +LR+L N+L +P
Sbjct: 69 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 128
Query: 613 CTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEE 672
+L LQ + L N ++ L +LHL NN++Q L LE
Sbjct: 129 ALN--NLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLET 186
Query: 673 LNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPE 708
L+L+ NKL+ P I RL L H+NNI PE
Sbjct: 187 LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 222
Score = 79.3 bits (194), Expect = 2e-14
Identities = 103/394 (26%), Positives = 163/394 (41%), Gaps = 41/394 (10%)
Query: 305 NLSHNKLG-LFPILLCEISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNFLTTLPE 362
+LS N L L P L + L EL LS N +P Q L +L+ L L N L +P
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 363 E-LGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV 420
E L L L SL + N S +PE +E L+ L + + N L + + LN + ++ +
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 421 DLRMN---HLKTMVIENLEGNKHITHVDLRDNRLTDLDLSS---LCSLEQLHCGRNQLRE 474
L +N H+ +NL + + L +NR+ L S L +LE L N+L+E
Sbjct: 140 TLALNRISHIPDYAFQNLTS---LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 196
Query: 475 LTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEA----KKIEVL 530
++ +RTL L L N ++ +P+ A + I
Sbjct: 197 FPVA---IRTL----------------GRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFY 237
Query: 531 DVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLF 590
D + + L L L G +Q P L LE+L L + LP +
Sbjct: 238 DNPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
Query: 591 SKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILH 650
+ LR L S N +E LPS L+ + L +N + + L+ L
Sbjct: 297 QQLPRLRVLELSHNQIEELPSL----HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 352
Query: 651 LANNQLQTFPASKLNKLEQLEELNLSGNKLKTIP 684
L+ N +++ + L L +L+L+ N+L T+P
Sbjct: 353 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 386
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 90.9 bits (224), Expect = 7e-18
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 52/449 (11%)
Query: 265 PEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCE-IST 323
P+ L +++ +L+L N + R L T L L LS+N+L L E + +
Sbjct: 153 PQALLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS 209
Query: 324 LTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTTL-PEELGNLQQLSSLGISFNNFS 381
L +LNL N LP + L +L+ L L GN L L P L +L L +S N
Sbjct: 210 LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 269
Query: 382 QIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKH 440
I V+ +L L ++ + N + + G + ++ +DL N + ++ + G
Sbjct: 270 AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 329
Query: 441 ITHVDLRDNRLTDL---DLSSLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLT 493
+ + L N + L L LE+L G N++R+L F L L N+L
Sbjct: 330 LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ 389
Query: 494 AVNVYPVPSL--LTFLDLSRNLLECVPDWACEAK-KIEVLDVSYNLLTEVPVRILSSLS- 549
V L + ++LS N L +P+ K+ L + + L + + LS
Sbjct: 390 EVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSG 449
Query: 550 LRKLMLGHNHV-----QNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASAN 604
LR+L L N + Q+L L E L LDL N LT LP LF L YL S N
Sbjct: 450 LRRLFLKDNGLVGIEEQSLWGLAE---LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
Query: 605 SLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKL 664
L LP+ ++L LQ + L +++N+L+ P S L
Sbjct: 507 RLAELPA-----DALGPLQRAFW---------------------LDVSHNRLEALPNSLL 540
Query: 665 NKLEQLEELNLSGNKLKTIPTTIANCKRL 693
L +L L+L N L+T +RL
Sbjct: 541 APLGRLRYLSLRNNSLRTFTPQPPGLERL 569
Score = 85.5 bits (210), Expect = 3e-16
Identities = 122/459 (26%), Positives = 192/459 (41%), Gaps = 51/459 (11%)
Query: 289 PGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQ 348
PGG L+ L G NLS + P +S+L LNL L Q LL L+
Sbjct: 111 PGGTQALW----LDGNNLS----SVPPAAFQNLSSLGFLNLQGGQLGSLEPQA--LLGLE 160
Query: 349 TLC---LDGNFLTTLP-EELGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCL 403
LC L+ N L +L + L+SLG+S N S++ + ++E L L + + N L
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Query: 404 EVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLS---SLC 460
VL + ++ + L N L + G + +DL N L + + L
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
Query: 461 SLEQLHCGRNQLRELTLSGF----SLRTLYASSNRLTAVNVYPVPSLLTF--LDLSRNLL 514
L++L+ RN + + F +LR L S NR+ + P LL L LS N +
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
Query: 515 ECV-PDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLPT--LVEHI 570
+ P + +E L + +N + ++ R L L L L HN +Q + +
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Query: 571 PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESL-PSACTGEESLSMLQL----- 624
+ V++L N L LP+ +F L L+ + L + P TG L L L
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 625 ----------------LYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLE 668
L LT+N LT + G L L L+ N+L PA L L+
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 669 QLEELNLSGNKLKTIPTT-IANCKRLHTLVAHSNNISIF 706
+ L++S N+L+ +P + +A RL L +N++ F
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 559
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 90.9 bits (224), Expect = 7e-18
Identities = 121/449 (26%), Positives = 187/449 (41%), Gaps = 52/449 (11%)
Query: 265 PEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCE-IST 323
P+ L +++ +L+L N + R L T L L LS+N+L L E + +
Sbjct: 115 PQALLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGS 171
Query: 324 LTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTTL-PEELGNLQQLSSLGISFNNFS 381
L +LNL N LP + L +L+ L L GN L L P L +L L +S N
Sbjct: 172 LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 231
Query: 382 QIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKH 440
I V+ +L L ++ + N + + G + ++ +DL N + ++ + G
Sbjct: 232 AIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 291
Query: 441 ITHVDLRDNRLTDL---DLSSLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLT 493
+ + L N + L L LE+L G N++R+L F L L N+L
Sbjct: 292 LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQ 351
Query: 494 AVNVYPVPSL--LTFLDLSRNLLECVPDWACEAK-KIEVLDVSYNLLTEVPVRILSSLS- 549
V L + ++LS N L +P+ K+ L + + L + + LS
Sbjct: 352 EVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSG 411
Query: 550 LRKLMLGHNHV-----QNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASAN 604
LR+L L N + Q+L L E L LDL N LT LP LF L YL S N
Sbjct: 412 LRRLFLKDNGLVGIEEQSLWGLAE---LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
Query: 605 SLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKL 664
L LP+ ++L LQ + L +++N+L+ P S L
Sbjct: 469 RLAELPA-----DALGPLQRAFW---------------------LDVSHNRLEALPNSLL 502
Query: 665 NKLEQLEELNLSGNKLKTIPTTIANCKRL 693
L +L L+L N L+T +RL
Sbjct: 503 APLGRLRYLSLRNNSLRTFTPQPPGLERL 531
Score = 85.5 bits (210), Expect = 3e-16
Identities = 122/459 (26%), Positives = 192/459 (41%), Gaps = 51/459 (11%)
Query: 289 PGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQ 348
PGG L+ L G NLS + P +S+L LNL L Q LL L+
Sbjct: 73 PGGTQALW----LDGNNLS----SVPPAAFQNLSSLGFLNLQGGQLGSLEPQA--LLGLE 122
Query: 349 TLC---LDGNFLTTLP-EELGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCL 403
LC L+ N L +L + L+SLG+S N S++ + ++E L L + + N L
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Query: 404 EVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLS---SLC 460
VL + ++ + L N L + G + +DL N L + + L
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
Query: 461 SLEQLHCGRNQLRELTLSGF----SLRTLYASSNRLTAVNVYPVPSLLTF--LDLSRNLL 514
L++L+ RN + + F +LR L S NR+ + P LL L LS N +
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
Query: 515 ECV-PDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLPT--LVEHI 570
+ P + +E L + +N + ++ R L L L L HN +Q + +
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Query: 571 PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESL-PSACTGEESLSMLQL----- 624
+ V++L N L LP+ +F L L+ + L + P TG L L L
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 625 ----------------LYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLE 668
L LT+N LT + G L L L+ N+L PA L L+
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 669 QLEELNLSGNKLKTIPTT-IANCKRLHTLVAHSNNISIF 706
+ L++S N+L+ +P + +A RL L +N++ F
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 521
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 90.5 bits (223), Expect = 1e-17
Identities = 102/411 (24%), Positives = 160/411 (38%), Gaps = 104/411 (25%)
Query: 354 GNFLTTLPEELGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDRVVMAGNCLEVLNLGVLN 412
G LT +PE L Q +L IS NN +Q+PE ++ L+ + +AGN L ++ L+
Sbjct: 45 GKGLTAVPEGLSAFTQ--ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALS 102
Query: 413 RMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQL 472
+ +K + L+ N LKT+ E + G + + L N +T + S L QL
Sbjct: 103 GLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL------- 155
Query: 473 RELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTF--LDLSRNLLECVPDWACE------- 523
R L+ N LT V V+P+ +L T L L+ N + +PD+A
Sbjct: 156 ----------RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVV 205
Query: 524 ------------------AKKIEVLDVSYNLLTEVPVRILSSLSLRKL------------ 553
+E LD++YN L E P I + SL++L
Sbjct: 206 LHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPD 265
Query: 554 -------------------------------------MLGHNHVQNLPTLVEHIPLEVLD 576
+ G + VQ P L + LE L
Sbjct: 266 GAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLT 325
Query: 577 LQHNALTRLPDTLFSKALNLRYLNASANSLESLPS--ACTGEESLSMLQLLYLTNNLLTD 634
L ++ +P+ L + LR L+ S N++ LPS C E +S L N +
Sbjct: 326 LTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEIS------LQRNQIYQ 379
Query: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPT 685
G + LRIL L+ N + + L + L++S N+L + PT
Sbjct: 380 IKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPT 430
Score = 83.2 bits (204), Expect = 2e-15
Identities = 109/443 (24%), Positives = 194/443 (43%), Gaps = 50/443 (11%)
Query: 254 VDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLG- 312
VD S L VPE L +++ +N QL D F L+ L L+ N L
Sbjct: 41 VDCSGKGLTAVPEGLSAFTQALDISM-NNITQLPE----DAFKNFPFLEELQLAGNDLSF 95
Query: 313 LFPILLCEISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNFLTTLPEE-LGNLQQL 370
+ P L + L L L N +PS+ I L LQ+L LD N +T++PE+ L QL
Sbjct: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
Query: 371 SSLGISFNNFSQIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKT 429
L + N+ +++P L L + +A N + + ++ + + L N +++
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215
Query: 430 MVIENLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFS----LR 483
+ +G ++ +DL N L + + +L SL++L N + + F LR
Sbjct: 216 LSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR 275
Query: 484 TLYASSNRLTAVN---VYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
T++ N L+ V + + L + + ++++ P+ +E L ++ ++ +
Sbjct: 276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVH-LESLTLTGTKISSI 334
Query: 541 PVRILSSLS-LRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYL 599
P + LR L L +N++++LP+ LE + LQ N + ++ + F ++LR L
Sbjct: 335 PNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRIL 394
Query: 600 NASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTF 659
+ S N + + S + L +TN L ++ N+L +F
Sbjct: 395 DLSRNLIHEI-------HSRAFATLGPITN-------------------LDVSFNELTSF 428
Query: 660 PASKLNKLEQLEELNLSGN-KLK 681
P LN L QL+ L GN KLK
Sbjct: 429 PTEGLNGLNQLK---LVGNFKLK 448
Score = 68.9 bits (167), Expect = 3e-11
Identities = 89/320 (27%), Positives = 143/320 (44%), Gaps = 32/320 (10%)
Query: 507 LDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLP 564
LD+S N + +P+ A + +E L ++ N L+ + + LS L L+ L L +N ++ +P
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 565 TLVEH--IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSML 622
+ L+ L L N +T +P+ F + LR+L NSL +P +L L
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLS--NLPTL 179
Query: 623 QLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKT 682
Q L L N ++ L +LHL NN++++ + L+ LE L+L+ N L
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
Query: 683 IPTTIANCKRLHTLVAHSNNISIFPE--ILQLPQIQFVDLSCNDLTEI------------ 728
P I L L HSN+IS+ P+ P ++ + L N L+ +
Sbjct: 240 FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLH 299
Query: 729 -LIPEALPATLQDLDLTGNTNLVLEHKTL---DIFSHITTLKIDQKPLPTTDST------ 778
L+ Q +LTG + LE TL I S L +QK L T D +
Sbjct: 300 SLVIRGASMVQQFPNLTGTVH--LESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
Query: 779 VTSTFWSHGLAEMAGQRNKL 798
+ S H L E++ QRN++
Sbjct: 358 LPSFNGCHALEEISLQRNQI 377
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 89.0 bits (219), Expect = 3e-17
Identities = 110/425 (25%), Positives = 202/425 (47%), Gaps = 26/425 (6%)
Query: 254 VDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGL 313
VD S L E+P +L S +YL+L N + P L +L +F L+ L L+ N L
Sbjct: 50 VDCSDLGLSELPSNL--SVFTSYLDLSMNNISQLLPNPLPSL-RF--LEELRLAGNALTY 104
Query: 314 FPI-LLCEISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNFLTTLPEE-LGNLQQL 370
P + +L L L N +P++ + NL +LQ+L LD N ++ +P L L
Sbjct: 105 IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSL 164
Query: 371 SSLGISFNNFSQIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKT 429
L + N ++IP + + L+ L + +A N + + ++ + + L N + +
Sbjct: 165 RHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS 224
Query: 430 MVIENLEGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGF----SLR 483
+ + +G + +DL N L + + +L +L++L N +R + F SL
Sbjct: 225 LGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLI 284
Query: 484 TLYASSNRLTAVN---VYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
T++ N + V +P L T + + PD A +E L ++ ++ +
Sbjct: 285 TIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTAN-LESLTLTGAQISSL 343
Query: 541 PVRILSSL-SLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYL 599
P + + L +L+ L L +N +++LP+ L+ +DL+HN + + F + L+LR L
Sbjct: 344 PQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSL 403
Query: 600 NASANSLESL-PSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQT 658
N + N + + P+A + +L L L L++NLL+ I L G HL++ N+ LQ+
Sbjct: 404 NLAWNKIAIIHPNAFS---TLPSLIKLDLSSNLLSSFPITGLHGLTHLKL--TGNHALQS 458
Query: 659 FPASK 663
+S+
Sbjct: 459 LISSE 463
Score = 88.6 bits (218), Expect = 4e-17
Identities = 109/415 (26%), Positives = 177/415 (42%), Gaps = 52/415 (12%)
Query: 357 LTTLPEELGNLQQLSSLGISFNNFSQI-PEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMN 415
L+ LP L S L +S NN SQ+ P L L+ + +AGN L + G +
Sbjct: 57 LSELPSNLSVFT--SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLY 114
Query: 416 HIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQL 472
+K + L+ N L+ + E L+ + + + L N ++ + S L SL L N L
Sbjct: 115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
Query: 473 RELTLSGFSLRTLYASSNRLTAVN-VYPVP-------SLLTFLDLSRNLLECVPDWACEA 524
E+ + F R+L A A+N ++ +P S L L L N + + +
Sbjct: 175 TEIPVQAF--RSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDG 232
Query: 525 -KKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP------------------- 564
+E LD++YN L E P I + +L++L N+++++P
Sbjct: 233 LHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292
Query: 565 ------TLVEHIP-LEVLDLQH-NALTRLPDTLFSKALNLRYLNASANSLESLPSACTGE 616
+ +H+P L L L + +T PD + NL L + + SLP +
Sbjct: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQ 350
Query: 617 ESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLS 676
L LQ+L L+ NLL D +P L+ + L +N++ +L L LNL+
Sbjct: 351 --LPNLQVLDLSYNLLED--LPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLA 406
Query: 677 GNKLKTI-PTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILI 730
NK+ I P + L L SN +S FP I L + + L+ N + LI
Sbjct: 407 WNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP-ITGLHGLTHLKLTGNHALQSLI 460
Score = 82.0 bits (201), Expect = 3e-15
Identities = 101/358 (28%), Positives = 160/358 (44%), Gaps = 36/358 (10%)
Query: 419 HVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQLREL 475
++DL MN++ ++ L + + + L N LT + + L SL+ L NQLR +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 476 TLSGF-SLRTLYASSNRLTAVNV-YPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVS 533
+LR+L S RL A ++ Y PS + L R+L W +
Sbjct: 130 PTEALQNLRSL--QSLRLDANHISYVPPSCFSGLHSLRHL------WLDD---------- 171
Query: 534 YNLLTEVPVRILSSLS-LRKLMLGHNHVQNLPTLV--EHIPLEVLDLQHNALTRLPDTLF 590
N LTE+PV+ SLS L+ + L N + ++P L VL L +N + L F
Sbjct: 172 -NALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCF 230
Query: 591 SKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILH 650
+L L+ + N+L+ P+A +LS L+ L +N + VG+ L +H
Sbjct: 231 DGLHSLETLDLNYNNLDEFPTAI---RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIH 287
Query: 651 LANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEIL 710
+N +Q S L +L L L+G T + L +L IS P+ +
Sbjct: 288 FYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTV 347
Query: 711 --QLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLK 766
QLP +Q +DLS N L E L ++ LQ +DL N + E K +D F + +L+
Sbjct: 348 CNQLPNLQVLDLSYN-LLEDLPSFSVCQKLQKIDLRHNE--IYEIK-VDTFQQLLSLR 401
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 86.3 bits (212), Expect = 2e-16
Identities = 95/349 (27%), Positives = 161/349 (46%), Gaps = 40/349 (11%)
Query: 277 LNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCE-ISTLTELNLSCNGFH 335
L + N + PG L L+ L+L++NKL + PI L + + +L L LS N
Sbjct: 88 LRIEKNELSRITPGAFRNL---GSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 144
Query: 336 DL-PSQIGNLLNLQTLCLDGNFLTTLPE-ELGNLQQLSSLGISFNNFSQI-PEVYEKLTM 392
+ P+ NL+ L L GN L +P+ +L L+ L + N+ + I P V++ L
Sbjct: 145 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 204
Query: 393 LDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLT 452
L + + N L + +G + + +++ + L+ N + + N ++ + L +N ++
Sbjct: 205 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 264
Query: 453 DLDLSSLCSLEQLH---CGRNQLRELTLSGF----SLRTLYASSNRLTAV--NVYPVPSL 503
L S L QL+ N L+EL+L F +LR L+ N ++++ NV+
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 504 LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL 563
L L LSRN + + A +N LTE LR+L L N +Q+L
Sbjct: 325 LQVLILSRNQISFISPGA------------FNGLTE----------LRELSLHTNALQDL 362
Query: 564 PTLVEHI--PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP 610
V + L+ + LQ+N L +LP +F+ L + N LE+LP
Sbjct: 363 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Score = 85.9 bits (211), Expect = 2e-16
Identities = 112/394 (28%), Positives = 177/394 (44%), Gaps = 44/394 (11%)
Query: 301 LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFLTT 359
L+ LN +L P L IS L L + N + P NL +L+ L L N L
Sbjct: 64 LQILNTHITELNESPFL--NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 121
Query: 360 LPEEL-GNLQQLSSLGISFNNFSQI-PEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHI 417
LP L L L SL +S N QI P + + + L + + GN LE + G + + +
Sbjct: 122 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 181
Query: 418 KHVDLRMN---HLKTMVIENLEGNKHITHVDLRDNRLTDLDLSS---LCSLEQLHCGRNQ 471
++L N H+ V ++L GN + L +NRLTD+ + + L +L++L +NQ
Sbjct: 182 TKLNLGKNSLTHISPRVFQHL-GNLQVLR--LYENRLTDIPMGTFDGLVNLQELALQQNQ 238
Query: 472 LRELTLSGF----SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKI 527
+ L+ F +L+ LY S+N ++ + PS+ F+ L + +
Sbjct: 239 IGLLSPGLFHNNHNLQRLYLSNNHISQLP----PSI--FMQLPQ---------------L 277
Query: 528 EVLDVSYNLLTEVPVRILSSL-SLRKLMLGHNHVQNLPTLV--EHIPLEVLDLQHNALTR 584
L + N L E+ + I + +LR+L L NH+ +LP V L+VL L N ++
Sbjct: 278 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF 337
Query: 585 LPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL 644
+ F+ LR L+ N+L+ L L+ LQ + L NN L +
Sbjct: 338 ISPGAFNGLTELRELSLHTNALQDLDGNVF--RMLANLQNISLQNNRLRQLPGNIFANVN 395
Query: 645 HLRILHLANNQLQTFPASKLNKLEQLEELNLSGN 678
L + L NNQL+ P + L +L EL L N
Sbjct: 396 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 73.2 bits (178), Expect = 2e-12
Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 16/271 (5%)
Query: 261 LEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLG-LFPILLC 319
L+ P H ++ L L N ++ G D L ++L NL N L + P +
Sbjct: 144 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKL---NLGKNSLTHISPRVFQ 200
Query: 320 EISTLTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTTL-PEELGNLQQLSSLGISF 377
+ L L L N D+P L+NLQ L L N + L P N L L +S
Sbjct: 201 HLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSN 260
Query: 378 NNFSQIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLE 436
N+ SQ+P ++ +L L+R+ + GN L+ L+LG+ M +++ + L NH+ ++
Sbjct: 261 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 320
Query: 437 GNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQLRELTLSGF----SLRTLYASS 489
+ + + L N+++ + + L L +L N L++L + F +L+ + +
Sbjct: 321 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 380
Query: 490 NRLTAV--NVYPVPSLLTFLDLSRNLLECVP 518
NRL + N++ + L + L N LE +P
Sbjct: 381 NRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Score = 61.2 bits (147), Expect = 6e-09
Identities = 82/350 (23%), Positives = 139/350 (39%), Gaps = 40/350 (11%)
Query: 484 TLYASSNRLTAVNVYPVPSLLTFLDL---SRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
+L + +T +N P ++ + L L P + L ++ N L +
Sbjct: 63 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVL 122
Query: 541 PVRILSSL-SLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLR 597
P+ + L SL L+L N + + + L+ L L N L +PD F + L
Sbjct: 123 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 182
Query: 598 YLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVG--------------- 642
LN NSL + + L LQ+L L N LTD + G
Sbjct: 183 KLNLGKNSLTHISPRVF--QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIG 240
Query: 643 ---------HLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTI-ANCKR 692
+ +L+ L+L+NN + P S +L QL L L GN LK + I
Sbjct: 241 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 300
Query: 693 LHTLVAHSNNISIFPE--ILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLV 750
L L + N+IS P+ L Q+Q + LS N ++ + P A + +L+ +TN +
Sbjct: 301 LRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQIS-FISPGAFNGLTELRELSLHTNAL 359
Query: 751 --LEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKL 798
L+ + +++ + + L + + +GL + Q N+L
Sbjct: 360 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV--NGLMAIQLQNNQL 407
Score = 40.8 bits (94), Expect = 0.009
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 570 IPLEVLDLQ--HNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYL 627
+P + LQ + +T L ++ F L L N L + +L L+ L L
Sbjct: 57 LPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF--RNLGSLRYLSL 114
Query: 628 TNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPT-T 686
NN L I + G L L L++NQL + ++ L+EL L GN L+ IP
Sbjct: 115 ANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGA 174
Query: 687 IANCKRLHTLVAHSNNIS-IFPEILQ-LPQIQFVDLSCNDLTEI 728
+ L L N+++ I P + Q L +Q + L N LT+I
Sbjct: 175 FDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 218
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 86.3 bits (212), Expect = 2e-16
Identities = 95/349 (27%), Positives = 161/349 (46%), Gaps = 40/349 (11%)
Query: 277 LNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCE-ISTLTELNLSCNGFH 335
L + N + PG L L+ L+L++NKL + PI L + + +L L LS N
Sbjct: 82 LRIEKNELSRITPGAFRNL---GSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLL 138
Query: 336 DL-PSQIGNLLNLQTLCLDGNFLTTLPE-ELGNLQQLSSLGISFNNFSQI-PEVYEKLTM 392
+ P+ NL+ L L GN L +P+ +L L+ L + N+ + I P V++ L
Sbjct: 139 QIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGN 198
Query: 393 LDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLT 452
L + + N L + +G + + +++ + L+ N + + N ++ + L +N ++
Sbjct: 199 LQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHIS 258
Query: 453 DLDLSSLCSLEQLH---CGRNQLRELTLSGF----SLRTLYASSNRLTAV--NVYPVPSL 503
L S L QL+ N L+EL+L F +LR L+ N ++++ NV+
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 504 LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL 563
L L LSRN + + A +N LTE LR+L L N +Q+L
Sbjct: 319 LQVLILSRNQISFISPGA------------FNGLTE----------LRELSLHTNALQDL 356
Query: 564 PTLVEHI--PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP 610
V + L+ + LQ+N L +LP +F+ L + N LE+LP
Sbjct: 357 DGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Score = 85.9 bits (211), Expect = 2e-16
Identities = 112/394 (28%), Positives = 177/394 (44%), Gaps = 44/394 (11%)
Query: 301 LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFLTT 359
L+ LN +L P L IS L L + N + P NL +L+ L L N L
Sbjct: 58 LQILNTHITELNESPFL--NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQV 115
Query: 360 LPEEL-GNLQQLSSLGISFNNFSQI-PEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHI 417
LP L L L SL +S N QI P + + + L + + GN LE + G + + +
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175
Query: 418 KHVDLRMN---HLKTMVIENLEGNKHITHVDLRDNRLTDLDLSS---LCSLEQLHCGRNQ 471
++L N H+ V ++L GN + L +NRLTD+ + + L +L++L +NQ
Sbjct: 176 TKLNLGKNSLTHISPRVFQHL-GNLQVLR--LYENRLTDIPMGTFDGLVNLQELALQQNQ 232
Query: 472 LRELTLSGF----SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKI 527
+ L+ F +L+ LY S+N ++ + PS+ F+ L + +
Sbjct: 233 IGLLSPGLFHNNHNLQRLYLSNNHISQLP----PSI--FMQLPQ---------------L 271
Query: 528 EVLDVSYNLLTEVPVRILSSL-SLRKLMLGHNHVQNLPTLV--EHIPLEVLDLQHNALTR 584
L + N L E+ + I + +LR+L L NH+ +LP V L+VL L N ++
Sbjct: 272 NRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF 331
Query: 585 LPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHL 644
+ F+ LR L+ N+L+ L L+ LQ + L NN L +
Sbjct: 332 ISPGAFNGLTELRELSLHTNALQDLDGNVF--RMLANLQNISLQNNRLRQLPGNIFANVN 389
Query: 645 HLRILHLANNQLQTFPASKLNKLEQLEELNLSGN 678
L + L NNQL+ P + L +L EL L N
Sbjct: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 73.2 bits (178), Expect = 2e-12
Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 16/271 (5%)
Query: 261 LEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLG-LFPILLC 319
L+ P H ++ L L N ++ G D L ++L NL N L + P +
Sbjct: 138 LQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKL---NLGKNSLTHISPRVFQ 194
Query: 320 EISTLTELNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTTL-PEELGNLQQLSSLGISF 377
+ L L L N D+P L+NLQ L L N + L P N L L +S
Sbjct: 195 HLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSN 254
Query: 378 NNFSQIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLE 436
N+ SQ+P ++ +L L+R+ + GN L+ L+LG+ M +++ + L NH+ ++
Sbjct: 255 NHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFS 314
Query: 437 GNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQLRELTLSGF----SLRTLYASS 489
+ + + L N+++ + + L L +L N L++L + F +L+ + +
Sbjct: 315 NLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 374
Query: 490 NRLTAV--NVYPVPSLLTFLDLSRNLLECVP 518
NRL + N++ + L + L N LE +P
Sbjct: 375 NRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Score = 61.2 bits (147), Expect = 6e-09
Identities = 82/350 (23%), Positives = 139/350 (39%), Gaps = 40/350 (11%)
Query: 484 TLYASSNRLTAVNVYPVPSLLTFLDL---SRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
+L + +T +N P ++ + L L P + L ++ N L +
Sbjct: 57 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVL 116
Query: 541 PVRILSSL-SLRKLMLGHNHVQNLPT--LVEHIPLEVLDLQHNALTRLPDTLFSKALNLR 597
P+ + L SL L+L N + + + L+ L L N L +PD F + L
Sbjct: 117 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 176
Query: 598 YLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVG--------------- 642
LN NSL + + L LQ+L L N LTD + G
Sbjct: 177 KLNLGKNSLTHISPRVF--QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIG 234
Query: 643 ---------HLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTI-ANCKR 692
+ +L+ L+L+NN + P S +L QL L L GN LK + I
Sbjct: 235 LLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPN 294
Query: 693 LHTLVAHSNNISIFPE--ILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLV 750
L L + N+IS P+ L Q+Q + LS N ++ + P A + +L+ +TN +
Sbjct: 295 LRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQIS-FISPGAFNGLTELRELSLHTNAL 353
Query: 751 --LEHKTLDIFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKL 798
L+ + +++ + + L + + +GL + Q N+L
Sbjct: 354 QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANV--NGLMAIQLQNNQL 401
Score = 40.8 bits (94), Expect = 0.009
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 570 IPLEVLDLQ--HNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYL 627
+P + LQ + +T L ++ F L L N L + +L L+ L L
Sbjct: 51 LPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF--RNLGSLRYLSL 108
Query: 628 TNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPT-T 686
NN L I + G L L L++NQL + ++ L+EL L GN L+ IP
Sbjct: 109 ANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGA 168
Query: 687 IANCKRLHTLVAHSNNIS-IFPEILQ-LPQIQFVDLSCNDLTEI 728
+ L L N+++ I P + Q L +Q + L N LT+I
Sbjct: 169 FDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI 212
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 85.9 bits (211), Expect = 2e-16
Identities = 118/421 (28%), Positives = 182/421 (43%), Gaps = 55/421 (13%)
Query: 327 LNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTT--LPEE-LGNLQQLSSLGISFNNFSQ 382
L+L N +LP +++ L L+TL L N +++ LP+E +L QL L ++ N S
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 383 IPEVYEK-LTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVI--ENLEGNK 439
P+ + L + D + A +E+ L ++ V L N L + + G++
Sbjct: 137 APQFLPRSLRVAD--LAANQVMEIFPL-TFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
Query: 440 HITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLTA- 494
I + L +N+L+ L S SLE+LH N + ++ S LR LY N+LT
Sbjct: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
Query: 495 ---VNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPV-RILSSLSL 550
+ L +LDLS N L VP A + + +L + N + +V R+ + L
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVP--AGLPRTLAILHLGRNRIRQVEAARLHGARGL 311
Query: 551 RKLMLGHNHV-------------QNLPTL------VEHIP------LEVLDLQHNALTRL 585
R L+L HN + + L TL ++ +P L L L HN + L
Sbjct: 312 RYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL 371
Query: 586 PDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH 645
L LN + N L S L L+ L L N LT + + G
Sbjct: 372 GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG--- 428
Query: 646 LRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKT---IPTTIANCKRL---HTLVAH 699
LR L L NQL+ L L+QL EL+L+ N+L+ P T + L H LV+H
Sbjct: 429 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSH 488
Query: 700 S 700
+
Sbjct: 489 T 489
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/247 (27%), Positives = 103/247 (41%), Gaps = 35/247 (14%)
Query: 507 LDLSRNLLECVP-DWACEAKKIEVLDVSYNLLTE--VPVRILSSLS-LRKLMLGHNHVQN 562
L L N L+ +P + + L++ NL++ +P SL+ L+ L + HN +
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 563 LPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESL---PSACTGEESL 619
P + L V DL N + + F + LR + N L + P A G E++
Sbjct: 137 APQFLPR-SLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAI 195
Query: 620 SMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNK 679
+ L L +NN L+ P L L LHL NN + P L++ QL EL L N+
Sbjct: 196 ATLSL---SNNQLS-YLPPSLPPSLER--LHLQNNLISKVPRGALSRQTQLRELYLQHNQ 249
Query: 680 LKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQ 739
L +LH+L +++DLS N LT +P LP TL
Sbjct: 250 LTDSGLDATTFSKLHSL-------------------EYLDLSHNQLT--TVPAGLPRTLA 288
Query: 740 DLDLTGN 746
L L N
Sbjct: 289 ILHLGRN 295
Score = 45.8 bits (107), Expect = 3e-04
Identities = 84/323 (26%), Positives = 135/323 (41%), Gaps = 25/323 (7%)
Query: 194 MHILPLVGGKIEEVKRRQ-YSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKV---VSQ 249
M I PL G+ ++ ++ S+AG + S E +A Q S + +
Sbjct: 156 MEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS-EAIATLSLSNNQLSYLPPSLPP 214
Query: 250 RISTVDLSCYSLEEVPEHLFYSQ-DITYLNLRHNFMQLERPGGLD--TLYKFSQLKGLNL 306
+ + L + +VP Q + L L+HN + GLD T K L+ L+L
Sbjct: 215 SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLT---DSGLDATTFSKLHSLEYLDL 271
Query: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFL--TTLPE- 362
SHN+L P L TL L+L N + +++ L+ L L N L + LP
Sbjct: 272 SHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAG 329
Query: 363 ELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDL 422
L L+ L +L + N ++P + L +V+ N + L L + ++L
Sbjct: 330 ALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALGARDLVATPGLTELNL 387
Query: 423 RMNHLKTMVIEN--LEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLREL---TL 477
N L + + + + + +DL N+LT L + L L RNQLR L L
Sbjct: 388 AYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPL 447
Query: 478 SGF-SLRTLYASSNRLTAVNVYP 499
+G LR L + NRL ++ P
Sbjct: 448 AGLDQLRELSLAHNRLRVGDIGP 470
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 85.9 bits (211), Expect = 2e-16
Identities = 118/421 (28%), Positives = 182/421 (43%), Gaps = 55/421 (13%)
Query: 327 LNLSCNGFHDLP-SQIGNLLNLQTLCLDGNFLTT--LPEE-LGNLQQLSSLGISFNNFSQ 382
L+L N +LP +++ L L+TL L N +++ LP+E +L QL L ++ N S
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 138
Query: 383 IPEVYEK-LTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVI--ENLEGNK 439
P+ + L + D + A +E+ L ++ V L N L + + G++
Sbjct: 139 APQFLPRSLRVAD--LAANQVMEIFPL-TFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 195
Query: 440 HITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLTA- 494
I + L +N+L+ L S SLE+LH N + ++ S LR LY N+LT
Sbjct: 196 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 255
Query: 495 ---VNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPV-RILSSLSL 550
+ L +LDLS N L VP A + + +L + N + +V R+ + L
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVP--AGLPRTLAILHLGRNRIRQVEAARLHGARGL 313
Query: 551 RKLMLGHNHV-------------QNLPTL------VEHIP------LEVLDLQHNALTRL 585
R L+L HN + + L TL ++ +P L L L HN + L
Sbjct: 314 RYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL 373
Query: 586 PDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH 645
L LN + N L S L L+ L L N LT + + G
Sbjct: 374 GARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG--- 430
Query: 646 LRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKT---IPTTIANCKRL---HTLVAH 699
LR L L NQL+ L L+QL EL+L+ N+L+ P T + L H LV+H
Sbjct: 431 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSH 490
Query: 700 S 700
+
Sbjct: 491 T 491
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/247 (27%), Positives = 103/247 (41%), Gaps = 35/247 (14%)
Query: 507 LDLSRNLLECVP-DWACEAKKIEVLDVSYNLLTE--VPVRILSSLS-LRKLMLGHNHVQN 562
L L N L+ +P + + L++ NL++ +P SL+ L+ L + HN +
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 138
Query: 563 LPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESL---PSACTGEESL 619
P + L V DL N + + F + LR + N L + P A G E++
Sbjct: 139 APQFLPR-SLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAI 197
Query: 620 SMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNK 679
+ L L +NN L+ P L L LHL NN + P L++ QL EL L N+
Sbjct: 198 ATLSL---SNNQLS-YLPPSLPPSLER--LHLQNNLISKVPRGALSRQTQLRELYLQHNQ 251
Query: 680 LKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQ 739
L +LH+L +++DLS N LT +P LP TL
Sbjct: 252 LTDSGLDATTFSKLHSL-------------------EYLDLSHNQLT--TVPAGLPRTLA 290
Query: 740 DLDLTGN 746
L L N
Sbjct: 291 ILHLGRN 297
Score = 45.8 bits (107), Expect = 3e-04
Identities = 84/323 (26%), Positives = 135/323 (41%), Gaps = 25/323 (7%)
Query: 194 MHILPLVGGKIEEVKRRQ-YSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKV---VSQ 249
M I PL G+ ++ ++ S+AG + S E +A Q S + +
Sbjct: 158 MEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS-EAIATLSLSNNQLSYLPPSLPP 216
Query: 250 RISTVDLSCYSLEEVPEHLFYSQ-DITYLNLRHNFMQLERPGGLD--TLYKFSQLKGLNL 306
+ + L + +VP Q + L L+HN + GLD T K L+ L+L
Sbjct: 217 SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLT---DSGLDATTFSKLHSLEYLDL 273
Query: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFL--TTLPE- 362
SHN+L P L TL L+L N + +++ L+ L L N L + LP
Sbjct: 274 SHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAG 331
Query: 363 ELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDL 422
L L+ L +L + N ++P + L +V+ N + L L + ++L
Sbjct: 332 ALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALGARDLVATPGLTELNL 389
Query: 423 RMNHLKTMVIEN--LEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLREL---TL 477
N L + + + + + +DL N+LT L + L L RNQLR L L
Sbjct: 390 AYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPL 449
Query: 478 SGF-SLRTLYASSNRLTAVNVYP 499
+G LR L + NRL ++ P
Sbjct: 450 AGLDQLRELSLAHNRLRVGDIGP 472
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 85.1 bits (209), Expect = 4e-16
Identities = 94/330 (28%), Positives = 144/330 (43%), Gaps = 36/330 (10%)
Query: 361 PEELGNLQQLSSLGISFNNFSQIP-EVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKH 419
P+ G L +L L ++ ++F + ++ LT L ++ + N LE L G+ + ++
Sbjct: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
Query: 420 VDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD---LSSLCSLEQLHCGRNQLRELT 476
+ L+ N L+ + + H+ ++L N L L L SL+ L N L L
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 477 LSGF----SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDV 532
F SL+ L+ SN N+ E P + +E L +
Sbjct: 210 QGVFGKLGSLQELFLDSN---------------------NISELPPQVFSQLFCLERLWL 248
Query: 533 SYNLLTEVPVRILSSL-SLRKLMLGHNHVQNLPT-LVEHIPLEV-LDLQHNALTRLPDTL 589
N +T +P+ I +SL +L L L N ++ LP L H P V L L HN L + +
Sbjct: 249 QRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGT 308
Query: 590 FSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRI 648
F+ NLR L S N++ LP+ + L L LYL +N LT P L +L L +
Sbjct: 309 FAHLSNLRSLMLSYNAITHLPAGIFRD--LEELVKLYLGSNNLT-ALHPALFQNLSKLEL 365
Query: 649 LHLANNQLQTFPASKLNKLEQLEELNLSGN 678
L L+ NQL T P + L L L GN
Sbjct: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 84.7 bits (208), Expect = 5e-16
Identities = 85/288 (29%), Positives = 129/288 (44%), Gaps = 15/288 (5%)
Query: 338 PSQIGNLLNLQTLCLDGN-FLTTLPEELGNLQQLSSLGISFNNFSQIPE-VYEKLTMLDR 395
P G L L+ L + G+ FL NL L L ++FN +PE +++ L L+
Sbjct: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
Query: 396 VVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD 455
+ + GN L+ L + + H+K ++L N L + E + + L +N L+ L
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
Query: 456 ---LSSLCSLEQLHCGRNQLRELTLSGFS----LRTLYASSNRLTAVNVYPVPSL--LTF 506
L SL++L N + EL FS L L+ N +T + + SL LTF
Sbjct: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
Query: 507 LDLSRNLLECVP-DWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLP 564
L L N+L +P + L +++N L V + LS LR LML +N + +LP
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Query: 565 TLV--EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLP 610
+ + L L L N LT L LF L L+ S N L +LP
Sbjct: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLP 377
Score = 66.2 bits (160), Expect = 2e-10
Identities = 77/287 (26%), Positives = 123/287 (42%), Gaps = 20/287 (6%)
Query: 505 TFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNL 563
+FL+LS N+ + L +++N+L +P + L+ L L L N +Q L
Sbjct: 108 SFLNLSTNIFS-------NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQAL 160
Query: 564 PTLVEH--IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621
P + L+ L+L N L +LP+ LF +L+ L S N+L LP G+ L
Sbjct: 161 PRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGK--LGS 218
Query: 622 LQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLK 681
LQ L+L +N +++ V L L L N + P S L L L+L N L+
Sbjct: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLR 278
Query: 682 TIPTTI-ANCKRLHTLVAHSNNISIFPE--ILQLPQIQFVDLSCNDLTEILIPEALPATL 738
+P + A+ L L N + E L ++ + LS N +T +P + L
Sbjct: 279 VLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH--LPAGIFRDL 336
Query: 739 QDLD--LTGNTNLVLEHKTL-DIFSHITTLKIDQKPLPTTDSTVTST 782
++L G+ NL H L S + L + + L T + T
Sbjct: 337 EELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDT 383
Score = 41.2 bits (95), Expect = 0.007
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 251 ISTVDLSCYSLEEVPEHLF-YSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHN 309
++ + L L +P LF ++ + L+L HN ++ G T S L+ L LS+N
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG---TFAHLSNLRSLMLSYN 323
Query: 310 KLGLFPI-LLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFLTTLPE 362
+ P + ++ L +L L N L P+ NL L+ L L N LTTLPE
Sbjct: 324 AITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPE 378
Score = 33.1 bits (74), Expect = 1.8
Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 4/124 (3%)
Query: 653 NNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTI-ANCKRLHTLVAHSNNISIFPEIL- 710
N QL F L +LE+L ++G+ + T I +N L L + N + PE L
Sbjct: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 711 -QLPQIQFVDLSCNDLTEILIPEALPAT-LQDLDLTGNTNLVLEHKTLDIFSHITTLKID 768
L ++ + L N L + P T L+ L+L N L + + + TLK+
Sbjct: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLS 201
Query: 769 QKPL 772
L
Sbjct: 202 NNAL 205
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 85.1 bits (209), Expect = 4e-16
Identities = 98/355 (27%), Positives = 149/355 (41%), Gaps = 50/355 (14%)
Query: 338 PSQIGNLLNLQTLCLDGNFLTTLPEEL-GNLQQLSSLGISFNNFSQIPE-VYEKLTMLDR 395
P +L+ L+TL L N +T LP L + L L + N I + +++KL L
Sbjct: 91 PGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQE 150
Query: 396 VVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD 455
+ + N L+ L + + ++K +DL N+L + L + + L NRL LD
Sbjct: 151 LALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLD 210
Query: 456 ---LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRN 512
L+SL +L +L RN +R + F +P+L + L LSRN
Sbjct: 211 SGLLNSLGALTELQFHRNHIRSIAPGAFDR-----------------LPNLSS-LTLSRN 252
Query: 513 LLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLV--EHI 570
L +P L S +L L L N + LP ++ E
Sbjct: 253 HLAFLPS----------------------ALFLHSHNLTLLTLFENPLAELPGVLFGEMG 290
Query: 571 PLEVLDLQHNALTRLPDTLFSKALNLRYLNASANS-LESLPSACTGEESLSMLQLLYLTN 629
L+ L L L LP F LRYL + + L +LP + L LQ+L L +
Sbjct: 291 GLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAF--QGLGELQVLALHS 348
Query: 630 NLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIP 684
N LT +L G LR + L N+L+ P + L LE + L N+L+T+P
Sbjct: 349 NGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
Score = 35.0 bits (79), Expect = 0.48
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 619 LSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGN 678
L L+ L L+ N +T +L + L L L +N L+ + KL L+EL L+ N
Sbjct: 97 LIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQN 156
Query: 679 KLKTIPTTI-ANCKRLHTLVAHSNNISIFPE 708
+L +P ++ N + L L NN++ P+
Sbjct: 157 QLDFLPASLFTNLENLKLLDLSGNNLTHLPK 187
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 79.7 bits (195), Expect = 2e-14
Identities = 105/411 (25%), Positives = 186/411 (45%), Gaps = 37/411 (9%)
Query: 240 QRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFS 299
++ SK+V ++L + L +P+++F ++ L+L +++ P + L
Sbjct: 408 EKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLEL-IPEVKLPSAVSQLVN-- 464
Query: 300 QLKGLNLSHNKLGL-FPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLT 358
LK L + H+ L + P L L L L +P + +L NL+ L L G
Sbjct: 465 -LKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG---C 520
Query: 359 TLPEELGNLQ-----QLSSLGISF--NNFSQIPEVY-EKLTMLDRVVMAGNCLEVLNLGV 410
LPE+L +Q L +L + ++ S+IP+V + L L ++ + +++ L
Sbjct: 521 VLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN 580
Query: 411 LNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD-LSSLCSLEQLHCGR 469
L +M ++K ++L L+ + ++ ++ +DLR+N L ++ + S L+ L C
Sbjct: 581 LKKMVNLKSLELISCDLER-IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSC-- 637
Query: 470 NQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEV 529
L L ++ + A L S L L L N +E +P K+
Sbjct: 638 -----LKLWHNNIAYIPAQIGAL---------SNLEQLSLDHNNIENLPLQLFLCTKLHY 683
Query: 530 LDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLPDT 588
LD+SYN LT +P I +L+ + +N+++ LP L + L+ L L N+L L
Sbjct: 684 LDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPH 743
Query: 589 LFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPV 639
+ + NL +L N LE+LP G +SL L + NLL +PV
Sbjct: 744 V-GELSNLTHLELIGNYLETLPPELEGCQSLKR-NCLIVEENLLNTLPLPV 792
Score = 57.8 bits (138), Expect = 7e-08
Identities = 64/233 (27%), Positives = 107/233 (45%), Gaps = 28/233 (12%)
Query: 517 VPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTL-----VEHIP 571
+P W K ++ L +S +L E LS++ L G ++NL TL + IP
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQ----LSTMQLE----GFQDLKNLRTLYLKSSLSRIP 553
Query: 572 LEVLDL----QHNALTRLPDTL-----FSKALNLRYLNASANSLESLPSACTGEESLSML 622
V DL Q +L L K +NL+ L + LE +P + +L L
Sbjct: 554 QVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHEL 613
Query: 623 QLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKT 682
L NNL T + I +L L L +N + PA ++ L LE+L+L N ++
Sbjct: 614 DLR--ENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPA-QIGALSNLEQLSLDHNNIEN 670
Query: 683 IPTTIANCKRLHTLVAHSNNISIFPEILQ-LPQIQFVDLSCNDLTEILIPEAL 734
+P + C +LH L N+++ PE +Q L +Q+ ++ N++ ++P+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIE--MLPDGL 721
Score = 50.4 bits (119), Expect = 1e-05
Identities = 47/174 (27%), Positives = 80/174 (45%), Gaps = 13/174 (7%)
Query: 231 ETLAEYQRWQRQASKVVSQ-----RISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ 285
+ L+ + W + + +Q + + L ++E +P LF + YL+L +N +
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
Query: 286 LERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLL 345
+ + S L+ +++N + + P L + L L L N +L +G L
Sbjct: 693 FIP----EEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELS 748
Query: 346 NLQTLCLDGNFLTTLPEELGNLQQL--SSLGISFNNFSQIP-EVYEKL-TMLDR 395
NL L L GN+L TLP EL Q L + L + N + +P V E+L T LD+
Sbjct: 749 NLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDK 802
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 79.7 bits (195), Expect = 2e-14
Identities = 105/411 (25%), Positives = 186/411 (45%), Gaps = 37/411 (9%)
Query: 240 QRQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFS 299
++ SK+V ++L + L +P+++F ++ L+L +++ P + L
Sbjct: 408 EKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLEL-IPEVKLPSAVSQLVN-- 464
Query: 300 QLKGLNLSHNKLGL-FPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLT 358
LK L + H+ L + P L L L L +P + +L NL+ L L G
Sbjct: 465 -LKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG---C 520
Query: 359 TLPEELGNLQ-----QLSSLGISF--NNFSQIPEVY-EKLTMLDRVVMAGNCLEVLNLGV 410
LPE+L +Q L +L + ++ S+IP+V + L L ++ + +++ L
Sbjct: 521 VLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN 580
Query: 411 LNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLD-LSSLCSLEQLHCGR 469
L +M ++K ++L L+ + ++ ++ +DLR+N L ++ + S L+ L C
Sbjct: 581 LKKMVNLKSLELISCDLER-IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSC-- 637
Query: 470 NQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEV 529
L L ++ + A L S L L L N +E +P K+
Sbjct: 638 -----LKLWHNNIAYIPAQIGAL---------SNLEQLSLDHNNIENLPLQLFLCTKLHY 683
Query: 530 LDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLPDT 588
LD+SYN LT +P I +L+ + +N+++ LP L + L+ L L N+L L
Sbjct: 684 LDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPH 743
Query: 589 LFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPV 639
+ + NL +L N LE+LP G +SL L + NLL +PV
Sbjct: 744 V-GELSNLTHLELIGNYLETLPPELEGCQSLKR-NCLIVEENLLNTLPLPV 792
Score = 57.8 bits (138), Expect = 7e-08
Identities = 64/233 (27%), Positives = 107/233 (45%), Gaps = 28/233 (12%)
Query: 517 VPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTL-----VEHIP 571
+P W K ++ L +S +L E LS++ L G ++NL TL + IP
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQ----LSTMQLE----GFQDLKNLRTLYLKSSLSRIP 553
Query: 572 LEVLDL----QHNALTRLPDTL-----FSKALNLRYLNASANSLESLPSACTGEESLSML 622
V DL Q +L L K +NL+ L + LE +P + +L L
Sbjct: 554 QVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHEL 613
Query: 623 QLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKT 682
L NNL T + I +L L L +N + PA ++ L LE+L+L N ++
Sbjct: 614 DLR--ENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPA-QIGALSNLEQLSLDHNNIEN 670
Query: 683 IPTTIANCKRLHTLVAHSNNISIFPEILQ-LPQIQFVDLSCNDLTEILIPEAL 734
+P + C +LH L N+++ PE +Q L +Q+ ++ N++ ++P+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIE--MLPDGL 721
Score = 50.4 bits (119), Expect = 1e-05
Identities = 47/174 (27%), Positives = 80/174 (45%), Gaps = 13/174 (7%)
Query: 231 ETLAEYQRWQRQASKVVSQ-----RISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQ 285
+ L+ + W + + +Q + + L ++E +P LF + YL+L +N +
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
Query: 286 LERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLL 345
+ + S L+ +++N + + P L + L L L N +L +G L
Sbjct: 693 FIP----EEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELS 748
Query: 346 NLQTLCLDGNFLTTLPEELGNLQQL--SSLGISFNNFSQIP-EVYEKL-TMLDR 395
NL L L GN+L TLP EL Q L + L + N + +P V E+L T LD+
Sbjct: 749 NLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDK 802
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 79.3 bits (194), Expect = 2e-14
Identities = 132/502 (26%), Positives = 203/502 (40%), Gaps = 122/502 (24%)
Query: 321 ISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNFLTTLPEELGN------LQQLSSL 373
++ L L L N +P + N+ LQ L L NFL +E+G+ L L L
Sbjct: 289 LTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLA---KEIGDAKFLHFLPSLIQL 345
Query: 374 GISFN----------NFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
+SFN N SQ + L +L L+ NL L+ + +++ +DL
Sbjct: 346 DLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLG 405
Query: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSS---LCS-------------LEQLH- 466
N +K + + K + +DL N+++ SS CS LEQLH
Sbjct: 406 TNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHY 465
Query: 467 ----------------------------------CGRNQLRELTLSGFS----LRTLYAS 488
+N + + S F L+ L S
Sbjct: 466 FRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLS 525
Query: 489 SNRLTAV---NVYPVPSLLTFLDLSRNLLECVPDWACEA-KKIEVLDVSYN---LLTEVP 541
N ++ + + + L +LD S N L+ + A E K+EVLD+S N +E
Sbjct: 526 GNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGI 585
Query: 542 VRILSSLS----LRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHN---ALTRLPDT----L 589
+L+ L+KLM+ N + + + +E L L+ + N L R D L
Sbjct: 586 THMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQL 645
Query: 590 FSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRIL 649
F L L L+ S NSL LPS + D P +L+ L
Sbjct: 646 FKNLLKLEELDISKNSLSFLPSG-------------------VFDGMPP------NLKNL 680
Query: 650 HLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKR-LHTLVAHSNNI-SIFP 707
LA N L++F KL L+ LE L+LS N+L T+P ++NC R L L+ +N I S+
Sbjct: 681 SLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTK 740
Query: 708 EILQ-LPQIQFVDLSCNDLTEI 728
LQ Q++++DLS N + I
Sbjct: 741 YFLQDAFQLRYLDLSSNKIQMI 762
Score = 59.7 bits (143), Expect = 2e-08
Identities = 92/362 (25%), Positives = 148/362 (40%), Gaps = 82/362 (22%)
Query: 327 LNLSCNG-FHDLPSQIGNLLNLQTLCLDGNFL--TTLPEELGNLQQLSSLGISFNNFSQI 383
L+LS N F S +L L+ L L GN + T E L +L L S N +
Sbjct: 498 LDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL 557
Query: 384 PEV-YEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV-----------DLRMNHLKTMV 431
+E+L L+ + ++ N + G+ + +N K++ D+ + +TM
Sbjct: 558 HSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTME 617
Query: 432 IENLE-----GNKHITHVDLR----DNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF-- 480
E+L GN H+D+ DNR L +L LE+L +N L L F
Sbjct: 618 SESLRTLEFRGN----HLDVLWREGDNRYLQL-FKNLLKLEELDISKNSLSFLPSGVFDG 672
Query: 481 ---SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537
+L+ L + N L + S L+C+ K +E LD+S+N L
Sbjct: 673 MPPNLKNLSLAKNGLKS--------------FSWKKLQCL-------KNLETLDLSHNQL 711
Query: 538 TEVPVRILS-SLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNL 596
T VP R+ + S SL+ L+L +N +++L A L
Sbjct: 712 TTVPERLSNCSRSLKNLILKNNQIRSLTKY----------------------FLQDAFQL 749
Query: 597 RYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPV----LVGHLHLRILHLA 652
RYL+ S+N ++ + E L+ L++L L +N C V V H + I +LA
Sbjct: 750 RYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLA 809
Query: 653 NN 654
+
Sbjct: 810 TD 811
Score = 47.8 bits (112), Expect = 7e-05
Identities = 107/441 (24%), Positives = 164/441 (37%), Gaps = 87/441 (19%)
Query: 287 ERPGGLDTLYKFSQLKGLNLSHNKL-GLFPILLCEISTLTELNLSCN------------- 332
E PGG+ T L L+ N + + P + L E++ CN
Sbjct: 58 EIPGGIPT-----NTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMC 112
Query: 333 --GFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKL 390
P L L++L LDGN L +P+ L QL SL + N FS E +L
Sbjct: 113 IKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEAN-NIFSIRKENLTEL 171
Query: 391 TMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNR 450
++ + + NC V + K L + LK + L+DN
Sbjct: 172 ANIEILYLGQNCYYRNPCYVSYSIE--KDAFLNLTKLKVL--------------SLKDNN 215
Query: 451 LTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLS 510
+T + +L +L+ N + ++ F N L + + LDLS
Sbjct: 216 VTAVPTVLPSTLTELYLYNNMIAKIQEDDF---------NNLNQLQI---------LDLS 257
Query: 511 RNLLECV-PDWACEAKKIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLPT--L 566
N C + C K N ++PV +L+ L+ L L N +Q++P
Sbjct: 258 GNCPRCYNAPFPCAPCK-------NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWF 310
Query: 567 VEHIPLEVLDLQHNALTR-LPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM-LQL 624
L+ LDL N L + + D F L LPS + S + LQ+
Sbjct: 311 KNINKLQELDLSQNFLAKEIGDAKF---------------LHFLPSLIQLDLSFNFELQV 355
Query: 625 LYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIP 684
+ NL Q L LRI +L++F S L+ L+ LE L+L N +K
Sbjct: 356 YRASMNL--SQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIAN 413
Query: 685 TTI-ANCKRLHTLVAHSNNIS 704
++ KRL + N IS
Sbjct: 414 LSMFKQFKRLKVIDLSVNKIS 434
Score = 46.6 bits (109), Expect = 2e-04
Identities = 67/260 (25%), Positives = 106/260 (40%), Gaps = 49/260 (18%)
Query: 535 NLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKAL 594
N L E+P + SL L L + L E +E+L L N R P +
Sbjct: 137 NQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIE 196
Query: 595 NLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANN 654
+LN L+ L++L L +N +T +P ++ L L+L NN
Sbjct: 197 KDAFLN------------------LTKLKVLSLKDNNVT--AVPTVLPST-LTELYLYNN 235
Query: 655 QLQTFPASKLNKLEQLEELNLSGN--KLKTIPTTIANCK----------------RLHTL 696
+ N L QL+ L+LSGN + P A CK L L
Sbjct: 236 MIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVL 295
Query: 697 VAHSNNISIFPE--ILQLPQIQFVDLSCN----DLTEILIPEALPATLQDLDLTGNTNLV 750
HSN++ P + ++Q +DLS N ++ + LP+ +Q LDL+ N L
Sbjct: 296 RLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQ-LDLSFNFELQ 354
Query: 751 LEHKTLDI---FSHITTLKI 767
+ ++++ FS + +LKI
Sbjct: 355 VYRASMNLSQAFSSLKSLKI 374
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 78.6 bits (192), Expect = 4e-14
Identities = 56/158 (35%), Positives = 85/158 (53%), Gaps = 12/158 (7%)
Query: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFS---QLKGLNLS 307
+ T++L ++ +PE + Q +TYLN+ N L TL K+ LK L +S
Sbjct: 136 LETLNLYHNCIKTIPEAIKNLQMLTYLNISRNL--------LSTLPKYLFDLPLKVLVVS 187
Query: 308 HNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNL 367
+NKL P + ++ L EL++SCN LP Q+G L +L+ L + N L LP+ELG+L
Sbjct: 188 NNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL 247
Query: 368 QQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEV 405
L L S N ++IP Y KL L +++ N L+V
Sbjct: 248 -PLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQV 284
Score = 72.4 bits (176), Expect = 3e-12
Identities = 50/154 (32%), Positives = 87/154 (56%), Gaps = 9/154 (5%)
Query: 576 DLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQ 635
DL N T +P ++ A L LN N ++++P A ++L ML L ++ NLL+
Sbjct: 117 DLSRNRFTEIPSDVWLFA-PLETLNLYHNCIKTIPEAI---KNLQMLTYLNISRNLLST- 171
Query: 636 CIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHT 695
+P + L L++L ++NN+L + P ++ KL+ L EL++S N+++ +P + L
Sbjct: 172 -LPKYLFDLPLKVLVVSNNKLVSIP-EEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRE 229
Query: 696 LVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEI 728
L NN+ + P+ L LP ++ +D SCN +TEI
Sbjct: 230 LNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEI 262
Score = 67.8 bits (164), Expect = 7e-11
Identities = 66/235 (28%), Positives = 110/235 (46%), Gaps = 35/235 (14%)
Query: 254 VDLSCYSLEEVPEHLFYSQDITYLNL-RHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLG 312
+ LS L + P + D T +L R+ F ++ ++ F+ L+ LNL HN +
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIP-----SDVWLFAPLETLNLYHNCIK 147
Query: 313 LFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSS 372
P + + LT LN+S N LP + + L L+ L + N L ++PEE+G L+ L
Sbjct: 148 TIPEAIKNLQMLTYLNISRNLLSTLPKYLFD-LPLKVLVVSNNKLVSIPEEIGKLKDLME 206
Query: 373 LGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVL--NLGVL---------NRMNHIKHVD 421
L IS N +P+ KL L + + N L VL LG L N++ I
Sbjct: 207 LDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCY 266
Query: 422 LRMNHLKTMVIEN-----------LEGNKHI-THVDLR-----DNRLTDLDLSSL 459
+++HL+ ++++N L+G HI +++++ D + LDL SL
Sbjct: 267 RKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSL 321
Score = 66.2 bits (160), Expect = 2e-10
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 11/203 (5%)
Query: 507 LDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTL 566
L LS L P + D+S N TE+P + L L L HN ++ +P
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
Query: 567 VEHIP-LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLL 625
++++ L L++ N L+ LP LF L L+ L S N L S+P EE + L+
Sbjct: 153 IKNLQMLTYLNISRNLLSTLPKYLFD--LPLKVLVVSNNKLVSIP-----EEIGKLKDLM 205
Query: 626 YLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIP 684
L + Q +P +G LH LR L++ N L P +L L L +L+ S NK+ IP
Sbjct: 206 ELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLP-DELGDLP-LVKLDFSCNKVTEIP 263
Query: 685 TTIANCKRLHTLVAHSNNISIFP 707
L ++ +N + + P
Sbjct: 264 VCYRKLHHLQVIILDNNPLQVPP 286
Score = 61.6 bits (148), Expect = 5e-09
Identities = 61/229 (26%), Positives = 100/229 (43%), Gaps = 27/229 (11%)
Query: 304 LNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEE 363
L+LS KL FP +++ T+ +LS N F ++PS + L+TL L N + T+PE
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
Query: 364 LGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLR 423
+ NLQ L+ L IS N S +P+ L + +V++ N V + ++ + +D+
Sbjct: 153 IKNLQMLTYLNISRNLLSTLPKYLFDLPL--KVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
Query: 424 MNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLREL--TLSGFS 481
N ++ + + L SL +L+ RN L L L
Sbjct: 211 CNEIQVL----------------------PQQMGKLHSLRELNIRRNNLHVLPDELGDLP 248
Query: 482 LRTLYASSNRLTAVNV-YPVPSLLTFLDLSRNLLECVPDWACEAKKIEV 529
L L S N++T + V Y L + L N L+ P C K+ +
Sbjct: 249 LVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHI 297
Score = 60.1 bits (144), Expect = 1e-08
Identities = 58/205 (28%), Positives = 88/205 (42%), Gaps = 28/205 (13%)
Query: 475 LTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSY 534
L+LSG LR S LT T DLSRN +P +E L++ +
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDT---------TQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
Query: 535 NLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKAL 594
N + +P I + L L + N + LP + +PL+VL + +N L +P+ + K
Sbjct: 144 NCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEI-GKLK 202
Query: 595 NLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQC-----------------I 637
+L L+ S N ++ LP SL L + ++L D+ I
Sbjct: 203 DLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEI 262
Query: 638 PVLVGHLH-LRILHLANNQLQTFPA 661
PV LH L+++ L NN LQ PA
Sbjct: 263 PVCYRKLHHLQVIILDNNPLQVPPA 287
Score = 55.8 bits (133), Expect = 3e-07
Identities = 56/222 (25%), Positives = 98/222 (44%), Gaps = 18/222 (8%)
Query: 407 NLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNK------------HITHVDLRDNRLTDL 454
N G L + ++ +D + + I +L G K T DL NR T++
Sbjct: 67 NPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEI 126
Query: 455 --DLSSLCSLEQLHCGRNQLREL--TLSGFSLRT-LYASSNRLTAVNVYPVPSLLTFLDL 509
D+ LE L+ N ++ + + + T L S N L+ + Y L L +
Sbjct: 127 PSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVV 186
Query: 510 SRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEH 569
S N L +P+ + K + LD+S N + +P ++ SLR+L + N++ LP +
Sbjct: 187 SNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGD 246
Query: 570 IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPS 611
+PL LD N +T +P + K +L+ + N L+ P+
Sbjct: 247 LPLVKLDFSCNKVTEIP-VCYRKLHHLQVIILDNNPLQVPPA 287
Score = 36.6 bits (83), Expect = 0.16
Identities = 37/120 (30%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 648 ILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP 707
IL L+ +L+ FP S + L + +LS N+ IP+ + L TL + N I P
Sbjct: 92 ILSLSGRKLRDFPGSGYD-LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIP 150
Query: 708 E-ILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLK 766
E I L + ++++S N L+ LP L DL L +V +K + I I LK
Sbjct: 151 EAIKNLQMLTYLNISRNLLS------TLPKYLFDLPL--KVLVVSNNKLVSIPEEIGKLK 202
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,122,586
Number of Sequences: 37866
Number of extensions: 2381736
Number of successful extensions: 15832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 11033
Number of HSP's gapped (non-prelim): 2930
length of query: 1323
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1209
effective length of database: 13,930,794
effective search space: 16842329946
effective search space used: 16842329946
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.