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Search of human proteins with 65301112
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 686 0.0
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 686 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 275 4e-74
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 275 4e-74
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 271 4e-73
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 271 4e-73
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 271 8e-73
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 270 1e-72
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 228 4e-60
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 228 4e-60
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 228 4e-60
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 228 4e-60
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 228 4e-60
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 228 4e-60
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 228 6e-60
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 228 6e-60
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 198 6e-51
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 140 2e-33
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 128 8e-30
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 111 1e-24
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 100 3e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 100 3e-21
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 100 3e-21
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 85 8e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 85 1e-16
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 83 4e-16
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 83 4e-16
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 83 4e-16
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 83 4e-16
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 79 4e-15
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 686 bits (1769), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 60
MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ
Sbjct: 343 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 402
Query: 61 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 120
KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ
Sbjct: 403 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 462
Query: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 180
YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD
Sbjct: 463 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 522
Query: 181 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 240
DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN
Sbjct: 523 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 582
Query: 241 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 300
LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM
Sbjct: 583 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 642
Query: 301 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
QQCDDGWFVGVSRRTQKFGTFPGNYVAPV
Sbjct: 643 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 686 bits (1769), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 60
MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ
Sbjct: 1 MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQ 60
Query: 61 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 120
KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ
Sbjct: 61 KGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQ 120
Query: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 180
YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD
Sbjct: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCD 180
Query: 181 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 240
DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN
Sbjct: 181 DGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQN 240
Query: 241 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 300
LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM
Sbjct: 241 LGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVM 300
Query: 301 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
QQCDDGWFVGVSRRTQKFGTFPGNYVAPV
Sbjct: 301 QQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 275 bits (703), Expect = 4e-74
Identities = 145/296 (48%), Positives = 191/296 (64%), Gaps = 52/296 (17%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R ++K+ + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 571 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 630
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 631 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 690
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
I GT RQGIFP +YV V + P +++P D
Sbjct: 691 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 719
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 720 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 759
Query: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 760 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 275 bits (703), Expect = 4e-74
Identities = 145/296 (48%), Positives = 191/296 (64%), Gaps = 52/296 (17%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R ++K+ + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 439 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 498
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 499 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 558
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
I GT RQGIFP +YV V + P +++P D
Sbjct: 559 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 587
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 588 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 627
Query: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 628 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 271 bits (694), Expect = 4e-73
Identities = 144/296 (48%), Positives = 189/296 (63%), Gaps = 52/296 (17%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 495 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 554
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 555 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 614
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
I GT RQGIFP +YV V + P +++P D
Sbjct: 615 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 643
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 644 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 683
Query: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 684 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 38.9 bits (89), Expect = 0.006
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 487 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 544
Query: 318 FGTFPGNYV 326
G FP Y+
Sbjct: 545 VGIFPRTYI 553
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 271 bits (694), Expect = 4e-73
Identities = 144/296 (48%), Positives = 189/296 (63%), Gaps = 52/296 (17%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 536 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 595
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 596 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 655
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
I GT RQGIFP +YV V + P +++P D
Sbjct: 656 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 684
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 685 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 724
Query: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 725 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 38.9 bits (89), Expect = 0.006
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 528 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 585
Query: 318 FGTFPGNYV 326
G FP Y+
Sbjct: 586 VGIFPRTYI 594
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 271 bits (692), Expect = 8e-73
Identities = 146/307 (47%), Positives = 188/307 (61%), Gaps = 54/307 (17%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 640 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 699
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 700 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 759
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
I GT RQGIFP +YV V + P +++P D
Sbjct: 760 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 788
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
+DL +SP R+ T P+ +L GP L+ S + P Q T
Sbjct: 789 MDLPFSSSPSRSA----TASPQLSHHSL-RAGPDLTES-------EKSYVQPQAQQRRVT 836
Query: 274 P-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFP 322
P Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFP
Sbjct: 837 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 896
Query: 323 GNYVAPV 329
GNYV P+
Sbjct: 897 GNYVKPL 903
Score = 38.9 bits (89), Expect = 0.006
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 632 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 689
Query: 318 FGTFPGNYV 326
G FP Y+
Sbjct: 690 VGIFPRTYI 698
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 270 bits (690), Expect = 1e-72
Identities = 153/339 (45%), Positives = 197/339 (58%), Gaps = 43/339 (12%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 811 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 870
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 871 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 930
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP--TSPRLTAAA---------------- 195
I GT RQGIFP +YV V + P ++ D LP +SP +A A
Sbjct: 931 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKA 990
Query: 196 ---RSARHPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHS 251
R P P + +S P D+ S + T E + LG+ P
Sbjct: 991 ERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAE 1050
Query: 252 RGPSH----------PLDLGTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELE 290
+ H G+ P Q TP Y+A+Y Y PQN+DELE
Sbjct: 1051 QTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 1110
Query: 291 LREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
LR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 1111 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
Score = 38.9 bits (89), Expect = 0.006
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 803 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 860
Query: 318 FGTFPGNYV 326
G FP Y+
Sbjct: 861 VGIFPRTYI 869
Score = 36.6 bits (83), Expect = 0.032
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 25 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 72
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 1065 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1124
Query: 73 KNWLEG--EHHGRLGIFPANYVEVL 95
W G + G FP NYV+ L
Sbjct: 1125 DGWFVGTSRRTKQFGTFPGNYVKPL 1149
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 226 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 285
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 286 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 345
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 346 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 390
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 391 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 435
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 436 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 470
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 471 FVGTSRRTKFFGTFPGNYV 489
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 308 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 367
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 368 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 427
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 428 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 487
Query: 167 YVQ 169
YV+
Sbjct: 488 YVK 490
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 192 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 245
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 246 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 303
Query: 321 FPGNYV 326
FP +YV
Sbjct: 304 FPISYV 309
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 558 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 617
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 618 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 677
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 678 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 722
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 723 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 767
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 768 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 802
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 803 FVGTSRRTKFFGTFPGNYV 821
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 640 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 700 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 759
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 760 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 819
Query: 167 YVQ 169
YV+
Sbjct: 820 YVK 822
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 524 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 577
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 578 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 635
Query: 321 FPGNYV 326
FP +YV
Sbjct: 636 FPISYV 641
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 395 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 454
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 455 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 514
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 515 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 559
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 560 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 604
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 605 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 639
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 640 FVGTSRRTKFFGTFPGNYV 658
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 477 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 536
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 537 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 596
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 597 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 656
Query: 167 YVQ 169
YV+
Sbjct: 657 YVK 659
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 361 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 414
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 415 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 472
Query: 321 FPGNYV 326
FP +YV
Sbjct: 473 FPISYV 478
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 465 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 524
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 525 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 584
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 585 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 629
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 630 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 674
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 675 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 709
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 710 FVGTSRRTKFFGTFPGNYV 728
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 547 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 607 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 666
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 667 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 726
Query: 167 YVQ 169
YV+
Sbjct: 727 YVK 729
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 431 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 484
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 485 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 542
Query: 321 FPGNYV 326
FP +YV
Sbjct: 543 FPISYV 548
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 378 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 437
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 438 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 497
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 498 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 542
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 543 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 587
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 588 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 622
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 623 FVGTSRRTKFFGTFPGNYV 641
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 460 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 519
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 520 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 579
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 580 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 639
Query: 167 YVQ 169
YV+
Sbjct: 640 YVK 642
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 344 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 397
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 398 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 455
Query: 321 FPGNYV 326
FP +YV
Sbjct: 456 FPISYV 461
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 228 bits (582), Expect = 4e-60
Identities = 131/319 (41%), Positives = 175/319 (54%), Gaps = 59/319 (18%)
Query: 12 RDFVYPSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIH 68
+D P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI
Sbjct: 400 KDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYIL 459
Query: 69 KEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDL 127
+++D+NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D
Sbjct: 460 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADT 519
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPT 187
VELS RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V +
Sbjct: 520 NVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK--------------- 564
Query: 188 SPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPA 247
+ T A P P + S D I P+R F+ +N+ G
Sbjct: 565 --KNTKGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG-- 609
Query: 248 LSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGW 307
P++A+Y Y P+NEDELELRE D +DVM++CDDGW
Sbjct: 610 -------------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGW 644
Query: 308 FVGVSRRTQKFGTFPGNYV 326
FVG SRRT+ FGTFPGNYV
Sbjct: 645 FVGTSRRTKFFGTFPGNYV 663
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 482 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 542 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 601
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 602 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 661
Query: 167 YVQ 169
YV+
Sbjct: 662 YVK 664
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/126 (26%), Positives = 60/126 (47%), Gaps = 12/126 (9%)
Query: 205 SALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSS 264
SA R+ +DL G ++ F+ + + ++ +P S+S S D+G S+
Sbjct: 366 SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPR---SYS---STLTDMGRSA 419
Query: 265 PN----TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGT 320
P T + P +A+Y ++ Q EL ++GD V ++++ D W+ G + G
Sbjct: 420 PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGI 477
Query: 321 FPGNYV 326
FP +YV
Sbjct: 478 FPISYV 483
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 228 bits (581), Expect = 6e-60
Identities = 130/314 (41%), Positives = 173/314 (55%), Gaps = 59/314 (18%)
Query: 17 PSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDK 73
P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 74 NWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELS 132
NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS
Sbjct: 803 NWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELS 862
Query: 133 FRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLT 192
RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 863 LRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNT 905
Query: 193 AAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSR 252
A P P + S D I P+R F+ +N+ G
Sbjct: 906 KGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG------- 947
Query: 253 GPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVS 312
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG S
Sbjct: 948 --------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 987
Query: 313 RRTQKFGTFPGNYV 326
RRT+ FGTFPGNYV
Sbjct: 988 RRTKFFGTFPGNYV 1001
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 820 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 880 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 939
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 940 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 999
Query: 167 YVQ 169
YV+
Sbjct: 1000 YVK 1002
Score = 45.1 bits (105), Expect = 9e-05
Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 23/159 (14%)
Query: 185 LPTSPRLTAAARSAR--------HPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPR 235
LP P ++ R+ R HP P A+ P D G PR SF +
Sbjct: 669 LPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRM--PRSA--SFQDVDTA 724
Query: 236 PQTQNLGTPGPALSHSRGP----SHPLDLGTSSPN----TSQIHWTPYRAMYQYRPQNED 287
+ + G AL P S D+G S+P T + P +A+Y ++ Q
Sbjct: 725 NSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSK 784
Query: 288 ELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
EL ++GD V ++++ D W+ G + G FP +YV
Sbjct: 785 ELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYV 821
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 228 bits (581), Expect = 6e-60
Identities = 130/314 (41%), Positives = 173/314 (55%), Gaps = 59/314 (18%)
Query: 17 PSSTRDPSASNGGGSPARRE---EKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDK 73
P S G +P R EK++ A+ +DF+AQ+ KEL+ +KGD VYI +++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 74 NWLEGEHHGRLGIFPANYVEVLPADEIPKPIK-PPTYQVLEYGEAVAQYTFKGDLEVELS 132
NW EGEHHGR+GIFP +YVE L E +P + PP Q E GEA+A+Y F D VELS
Sbjct: 899 NWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELS 958
Query: 133 FRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLT 192
RKG+ + L+++V++NWYEG+I GT RQGIFP SYV+V + + T
Sbjct: 959 LRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK-----------------KNT 1001
Query: 193 AAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSR 252
A P P + S D I P+R F+ +N+ G
Sbjct: 1002 KGAEDYPDPPIPHSYSS--DRIHSLSSNKPQRPVFTH---------ENIQGGG------- 1043
Query: 253 GPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVS 312
P++A+Y Y P+NEDELELRE D +DVM++CDDGWFVG S
Sbjct: 1044 --------------------EPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 1083
Query: 313 RRTQKFGTFPGNYV 326
RRT+ FGTFPGNYV
Sbjct: 1084 RRTKFFGTFPGNYV 1097
Score = 69.7 bits (169), Expect = 3e-12
Identities = 54/183 (29%), Positives = 81/183 (44%), Gaps = 29/183 (15%)
Query: 16 YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNW 75
Y P + P + + A K++F A + EL+L+KGD V + K VD+NW
Sbjct: 916 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975
Query: 76 LEGEHHG--RLGIFPANYVEVLP-----ADEIPKPIKPPTYQ------------------ 110
EG+ G R GIFP +YVEV+ A++ P P P +Y
Sbjct: 976 YEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFT 1035
Query: 111 ---VLEYGEAV-AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPAS 166
+ GE A Y + E EL R+ + I ++ K ++ W+ G T G FP +
Sbjct: 1036 HENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGN 1095
Query: 167 YVQ 169
YV+
Sbjct: 1096 YVK 1098
Score = 45.1 bits (105), Expect = 9e-05
Identities = 43/159 (27%), Positives = 66/159 (41%), Gaps = 23/159 (14%)
Query: 185 LPTSPRLTAAARSAR--------HPSSPS-ALRSPADPIDLGGQTSPRRTGFSFPTQEPR 235
LP P ++ R+ R HP P A+ P D G PR SF +
Sbjct: 765 LPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRM--PRSA--SFQDVDTA 820
Query: 236 PQTQNLGTPGPALSHSRGP----SHPLDLGTSSPN----TSQIHWTPYRAMYQYRPQNED 287
+ + G AL P S D+G S+P T + P +A+Y ++ Q
Sbjct: 821 NSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSK 880
Query: 288 ELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
EL ++GD V ++++ D W+ G + G FP +YV
Sbjct: 881 ELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYV 917
Score = 42.4 bits (98), Expect = 6e-04
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A Y + EL LR+GDRV ++++ D W+ G T + G FP +YV V
Sbjct: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 198 bits (503), Expect = 6e-51
Identities = 113/247 (45%), Positives = 146/247 (59%), Gaps = 20/247 (8%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 789 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 848
Query: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 849 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA-- 211
I GT RQGIFP +YV V + P ++ D LP S + +A ++ SS S L +PA
Sbjct: 909 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
Query: 212 ------------------DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRG 253
+ I L RR+ P P P+ T ALS
Sbjct: 969 SLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRAS 1028
Query: 254 PSHPLDL 260
PS L L
Sbjct: 1029 PSLSLSL 1035
Score = 99.0 bits (245), Expect = 5e-21
Identities = 46/80 (57%), Positives = 56/80 (70%), Gaps = 11/80 (13%)
Query: 261 GTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFV 309
G+ P Q TP Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFV
Sbjct: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
Query: 310 GVSRRTQKFGTFPGNYVAPV 329
G SRRT++FGTFPGNYV P+
Sbjct: 1271 GTSRRTKQFGTFPGNYVKPL 1290
Score = 38.9 bits (89), Expect = 0.006
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 838
Query: 318 FGTFPGNYV 326
G FP Y+
Sbjct: 839 VGIFPRTYI 847
Score = 38.5 bits (88), Expect = 0.008
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
A + + + E+ R+G+R+ +++Q D+ W+ G T + G FP YV
Sbjct: 874 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
Score = 36.6 bits (83), Expect = 0.032
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 25 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 72
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 1206 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1265
Query: 73 KNWLEG--EHHGRLGIFPANYVEVL 95
W G + G FP NYV+ L
Sbjct: 1266 DGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 35.0 bits (79), Expect = 0.092
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 103 PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGI 162
P + T Q L +A+ Y + D E+EL R G+ + ++ K ++ W+ G T + G
Sbjct: 1224 PDRSQTSQDLFSYQALYSYIPQNDDELEL--RDGDIVDVMEKCDDGWFVGTSRRTKQFGT 1281
Query: 163 FPASYVQ 169
FP +YV+
Sbjct: 1282 FPGNYVK 1288
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 140 bits (353), Expect = 2e-33
Identities = 124/411 (30%), Positives = 179/411 (43%), Gaps = 114/411 (27%)
Query: 19 STRDPSASNGGG-------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEV 71
S++D +S GG SP R + A+ ++++ + P +L KGDI+ + ++V
Sbjct: 108 SSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQV 167
Query: 72 DKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFK-GDLEVE 130
D+NW GE +G G FP N+V+++ P P PP + A Y F+ D E +
Sbjct: 168 DENWYHGEVNGIHGFFPTNFVQIIK----PLPQPPP--------QCKALYDFEVKDKEAD 215
Query: 131 ---LSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLP- 186
L F K + + +IR+V+ENW EG + + GIFP SYV+ + + + D P +P
Sbjct: 216 KDCLPFAKDDVLTVIRRVDENWAEGML--ADKIGIFPISYVEFNSAAKQLIEWDKPPVPG 273
Query: 187 --------------TSPR----------------LTAAARSA-----RHPS--SPSALRS 209
T+P+ LT A +S+ RH SP L S
Sbjct: 274 VDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLIS 333
Query: 210 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPS--HPLD------LG 261
++P + S P+Q T + TP P+ + GPS P D LG
Sbjct: 334 SSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALG 393
Query: 262 TSSP------------------------------------NTSQI-HWTP------YRAM 278
T +P +T QI H P Y A+
Sbjct: 394 TLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAI 453
Query: 279 YQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y Y P+ EDELELR+G+ V ++C DGWF G S T K G FPGNYVAPV
Sbjct: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 16/91 (17%)
Query: 236 PQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGD 295
P Q + GP L+ SR P + H R + Y PQ+E ELEL+EGD
Sbjct: 811 PPRQACSSLGPVLNESR------------PVVCERH----RVVVSYPPQSEAELELKEGD 854
Query: 296 RVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
V V ++ +DGWF G +R K G FPG++V
Sbjct: 855 IVFVHKKREDGWFKGTLQRNGKTGLFPGSFV 885
Score = 47.8 bits (112), Expect = 1e-05
Identities = 20/52 (38%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 44 RLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG--EHHGRLGIFPANYVE 93
R+ + QS EL L++GDIV++HK+ + W +G + +G+ G+FP ++VE
Sbjct: 835 RVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 46.2 bits (108), Expect = 4e-05
Identities = 55/232 (23%), Positives = 88/232 (37%), Gaps = 29/232 (12%)
Query: 47 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIPKPI 104
+ + + EL L+KG++ + + W +G H ++G+FP NYV
Sbjct: 454 YPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV------------ 501
Query: 105 KPPTYQVLEYGEA-----VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGR 159
P T V +A A T +G V S G +K+ N G
Sbjct: 502 APVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGP----AQKLQGNGVAGS-PSVVP 556
Query: 160 QGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQ 219
+ A+++Q S + ++ L G R +A + P+A +P + G
Sbjct: 557 AAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAG- 615
Query: 220 TSPRRTGF---SFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTS 268
SP G S + +P P T A+S SR S PL ++P TS
Sbjct: 616 LSPASVGLSHHSLASPQPAPLMPGSATHTAAISISRA-SAPLACAAAAPLTS 666
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 8/103 (7%)
Query: 118 VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLR 177
VA Y + E EL RKGE + + + W++G T + G+FP +YV P R
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV----APVTR 506
Query: 178 LCDDGPQLPTSPRLTAAARSARHPS--SPSALRSPADPIDLGG 218
+ Q ++ A +++R + SPS PA + G
Sbjct: 507 AVTNASQAKVP--MSTAGQTSRGVTMVSPSTAGGPAQKLQGNG 547
Score = 38.1 bits (87), Expect = 0.011
Identities = 13/42 (30%), Positives = 27/42 (64%)
Query: 128 EVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
E EL ++G+ + + +K + W++G + G+ G+FP S+V+
Sbjct: 845 EAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 128 bits (321), Expect = 8e-30
Identities = 93/350 (26%), Positives = 152/350 (43%), Gaps = 64/350 (18%)
Query: 31 SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN 90
+PA + + + ++ + P +L KGDI+ + ++VD+ W GE HG G PA+
Sbjct: 187 APAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPAS 246
Query: 91 YVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVE--LSFRKGEHICLIRKVNEN 148
Y++ + P P PP G+A+ + K + + L+F K E + ++R+V+EN
Sbjct: 247 YIQCIQ----PLPHAPP------QGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDEN 296
Query: 149 WYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGP----------QLPTSPRLTAAARSA 198
W EG + + GIFP YV+++ + + D P LP+ A+ +
Sbjct: 297 WAEGML--GDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPS 354
Query: 199 RHPSSPSALRSPADPIDLGGQTSPRRTGF-----SFPTQEPRPQTQNLGTPGPALSHSRG 253
SS A+ + +D G + + +R F + + + ++ P L S
Sbjct: 355 PTLSSSGAVSAFQRRVD-GKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSD 413
Query: 254 PSHPLDLG----------------------------------TSSPNTSQIHWTPYRAMY 279
P +G +P Q+ Y A+Y
Sbjct: 414 PRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALY 473
Query: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Y+PQ DELEL +G+ V+++C DGWF G S RT G FPGNYV PV
Sbjct: 474 AYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 58.9 bits (141), Expect = 6e-09
Identities = 27/70 (38%), Positives = 41/70 (58%)
Query: 257 PLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQ 316
PL + P + YR + Y PQ+E E+EL+EGD V V ++ +DGW+ G +R
Sbjct: 810 PLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNG 869
Query: 317 KFGTFPGNYV 326
+ G FPG++V
Sbjct: 870 RTGLFPGSFV 879
Score = 49.3 bits (116), Expect = 5e-06
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 10 GRRDFVYPSSTRDPSASNGGGSPARREEKK---RKAARLKFDFQAQSPKELTLQKGDIVY 66
G D + S +R S A R E K R+ R+ + QS E+ L++GDIV+
Sbjct: 796 GSLDLNFTSPSRQAPLSMA----AIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIVF 851
Query: 67 IHKEVDKNWLEG--EHHGRLGIFPANYVE 93
+HK+ + W +G + +GR G+FP ++VE
Sbjct: 852 VHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 48.1 bits (113), Expect = 1e-05
Identities = 47/185 (25%), Positives = 67/185 (36%), Gaps = 16/185 (8%)
Query: 106 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 165
PP Q L +A Y +K EL KGE ++ K + W++G TG G+FP
Sbjct: 459 PPKVQ-LPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPG 517
Query: 166 SYV-QVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRR 224
+YV VSR P + L + HP S S L + R
Sbjct: 518 NYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS----------LSSLATATR 567
Query: 225 TGFSFPTQEPRPQTQNLGTP-GPALSHSRGPSHP---LDLGTSSPNTSQIHWTPYRAMYQ 280
T + Q P G L HS P+ + T++ + +Q P +
Sbjct: 568 PALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSP 627
Query: 281 YRPQN 285
R QN
Sbjct: 628 LRTQN 632
Score = 41.2 bits (95), Expect = 0.001
Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 8/93 (8%)
Query: 81 HGRLGIFPANYVEVLPADEIP---KPIKP-PTYQVLEYGEAVAQYTFKGDLEVELSFRKG 136
H + G N+ P+ + P I+P P E V Y + + E+EL ++G
Sbjct: 792 HRKAGSLDLNFTS--PSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIEL--KEG 847
Query: 137 EHICLIRKVNENWYEGRITGTGRQGIFPASYVQ 169
+ + + +K + WY+G + GR G+FP S+V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 34.3 bits (77), Expect = 0.16
Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 247 ALSHSRGPSHPLDLGTSSPNTSQIHWTPY-RAMYQYRPQNEDELELREGDRVDVMQQCDD 305
A + G L ++P PY +A+Y Y + +L+ +GD + + ++ D+
Sbjct: 170 AAGSTAGSLRELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDE 229
Query: 306 GWFVGVSRRTQKFGTFPGNYV 326
W+ G TQ G P +Y+
Sbjct: 230 QWYHGELHGTQ--GFLPASYI 248
Score = 33.5 bits (75), Expect = 0.27
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 47 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYVEVLPADEIP 101
+ ++ Q EL L KG++ + ++ W +G G G+FP NY V P +P
Sbjct: 473 YAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNY--VTPVSRVP 527
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 111 bits (277), Expect = 1e-24
Identities = 93/325 (28%), Positives = 152/325 (46%), Gaps = 53/325 (16%)
Query: 43 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 102
A+ +++ Q+P +L KGDI+ + +++D+NW +GE +G G FPA+ VEV+ ++P+
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 103 PIKPPTYQVLEYGEAVAQYTF------KGDLEVELSFRKGEHICLIRKVNENWYEGRITG 156
P PP + L Y F K + + L+F K + I +I +V+ENW EG++
Sbjct: 188 P--PPLCRAL--------YNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL-- 235
Query: 157 TGRQGIFPASYVQVSREPR-LRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID 215
+ GIFP +V+ + R L + G Q + L+ + S+R +S + R P
Sbjct: 236 GDKVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTS-TLRRGPGSRRK 294
Query: 216 LGGQTSPRRTGFSFPTQEPRPQTQNL-GTPGPALSHSRGPS------------------- 255
+ GQ S + P +++ P L S PS
Sbjct: 295 VPGQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVPSSCVGQV 354
Query: 256 ---HPLDLG-------TSSPNTSQ-IHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCD 304
HP + S P + Q + + A++ Y DEL+L++G+ V V+ +C
Sbjct: 355 STYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQ 414
Query: 305 DGWFVGVSRRTQKFGTFPGNYVAPV 329
DGW GVS T + G FP NYV P+
Sbjct: 415 DGWLRGVSLVTGRVGIFPNNYVIPI 439
Score = 40.8 bits (94), Expect = 0.002
Identities = 41/147 (27%), Positives = 61/147 (41%), Gaps = 26/147 (17%)
Query: 106 PPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPA 165
P + Q L VA +++ EL +KGE + ++ K + W G TGR GIFP
Sbjct: 374 PGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPN 433
Query: 166 SYV----------QVSREPRL---------RLCDDGPQLPTSPRLTAAARSARHPSS-PS 205
+YV SR P L + G PR + +S P++ +
Sbjct: 434 NYVIPIFRKTSSFPDSRSPGLYTTWTLSTSSVSSQGSISEGDPRQSRPFKSVFVPTAIVN 493
Query: 206 ALRSPADPIDLG------GQTSPRRTG 226
+RS A P LG G++S R+ G
Sbjct: 494 PVRSTAGPGTLGQGSLRKGRSSMRKNG 520
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 99.8 bits (247), Expect = 3e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 401 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 460
Query: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 461 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 518
Query: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 568
Query: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
+D P + T + S S + + P + L T+ SF +
Sbjct: 569 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 628
Query: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 629 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 683
Query: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 684 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 725
Score = 75.1 bits (183), Expect = 8e-14
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 613 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 667
Query: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 668 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 725
Query: 169 Q 169
Q
Sbjct: 726 Q 726
Score = 62.4 bits (150), Expect = 5e-10
Identities = 68/289 (23%), Positives = 120/289 (41%), Gaps = 30/289 (10%)
Query: 61 KGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG- 115
+GD++ + K+ + N+LE GE GR+ + + L +P P Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 116 -EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV---- 170
AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDI 496
Query: 171 ------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSP 222
RE C G + + S L+ + G+
Sbjct: 497 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
Query: 223 RRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMY 279
R F EP ++ T G + ++ P + D G++S N+ W A++
Sbjct: 557 RTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALH 611
Query: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
+ + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 612 SFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
Score = 52.4 bits (124), Expect = 6e-07
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 32.7 bits (73), Expect = 0.46
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 99.8 bits (247), Expect = 3e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 437 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 496
Query: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 497 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 554
Query: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 604
Query: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
+D P + T + S S + + P + L T+ SF +
Sbjct: 605 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 664
Query: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 665 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 719
Query: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 720 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 761
Score = 75.1 bits (183), Expect = 8e-14
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 649 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 703
Query: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 704 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 761
Query: 169 Q 169
Q
Sbjct: 762 Q 762
Score = 62.4 bits (150), Expect = 5e-10
Identities = 68/289 (23%), Positives = 120/289 (41%), Gaps = 30/289 (10%)
Query: 61 KGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG- 115
+GD++ + K+ + N+LE GE GR+ + + L +P P Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 116 -EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV---- 170
AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDI 532
Query: 171 ------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSP 222
RE C G + + S L+ + G+
Sbjct: 533 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
Query: 223 RRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMY 279
R F EP ++ T G + ++ P + D G++S N+ W A++
Sbjct: 593 RTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALH 647
Query: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
+ + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 648 SFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
Score = 52.4 bits (124), Expect = 6e-07
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 32.7 bits (73), Expect = 0.46
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 99.8 bits (247), Expect = 3e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 460 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 519
Query: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 520 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 577
Query: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 627
Query: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
+D P + T + S S + + P + L T+ SF +
Sbjct: 628 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 687
Query: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 688 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 742
Query: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 743 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 784
Score = 75.1 bits (183), Expect = 8e-14
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 672 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 726
Query: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 727 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 784
Query: 169 Q 169
Q
Sbjct: 785 Q 785
Score = 72.4 bits (176), Expect = 5e-13
Identities = 73/302 (24%), Positives = 129/302 (42%), Gaps = 30/302 (9%)
Query: 48 DFQAQSPKELTLQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPI 104
D +Q+P EL+ ++GD++ + K+ + N+LE GE GR+ + + L +P
Sbjct: 425 DIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPN 484
Query: 105 KPPTYQ-VLEYG--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQG 161
P Q ++ G AV + F + +L+ GE + L+ K++ +WY G + G
Sbjct: 485 DPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIG 542
Query: 162 IFPASYVQV----------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRS 209
IFPA+YV+V RE C G + + S L+
Sbjct: 543 IFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKE 602
Query: 210 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-N 266
+ G+ R F EP ++ T G + ++ P + D G++S N
Sbjct: 603 YVNEEWARGEVRGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 659
Query: 267 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
+ W A++ + + D+L + GDR+ ++++ D W G R + G FP +V
Sbjct: 660 SLPAEWC--EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFV 715
Query: 327 AP 328
P
Sbjct: 716 RP 717
Score = 52.4 bits (124), Expect = 6e-07
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 32.7 bits (73), Expect = 0.46
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 85.1 bits (209), Expect = 8e-17
Identities = 79/325 (24%), Positives = 144/325 (44%), Gaps = 46/325 (14%)
Query: 43 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 102
A ++FD+QAQ ELT+ G+I+ ++ D W EG+ +GR G+FP N+V + +
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
Query: 103 PI------KP----PTYQVLEYGEAVAQYTFKGDL---------------EVELSFRKGE 137
P+ KP P+ L E + + +G+ + EL + G+
Sbjct: 64 PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGD 123
Query: 138 HICLIRKVNENWYEGRITGTGRQGIFPASYVQ--VSREPRLRLCDDGPQLPTSPRLTAAA 195
I ++ +V E W+EG + G+ G+FP+++++ L + D +S R T +
Sbjct: 124 IIEVVGEVEEGWWEGVL--NGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGS 181
Query: 196 RSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLGTPGPALSH 250
S SS S A+ P++ G F + + + +++ L
Sbjct: 182 ESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
Query: 251 SRGPSHPLDLGTSSPNTSQIHWTP-------YRAMYQYRPQNEDELELREGDRVDVMQQ- 302
+ L T++P++S+ + ++ Y QN+DEL ++EGD V ++ +
Sbjct: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
Query: 303 -CDDGWFVGVSRRTQKFGTFPGNYV 326
D GW+ G + G FP N+V
Sbjct: 301 CIDVGWWEG--ELNGRRGVFPDNFV 323
Score = 65.9 bits (159), Expect = 5e-11
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)
Query: 17 PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 74
P++T P +S + K + ++ F ++AQ+ ELT+++GDIV I+K+ +D
Sbjct: 249 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 305
Query: 75 WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 129
W EGE +GR G+FP N+V++LP D PK PP+ V++ G +
Sbjct: 306 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 356
Query: 130 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 189
RK E I+K+ E T + + REP+L L P +P P
Sbjct: 357 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 399
Query: 190 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 249
+ R P + S R A P P + RP GP L+
Sbjct: 400 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 430
Query: 250 HSRGPSHPLDLGTSS 264
H+RG S +DL SS
Sbjct: 431 HTRGDSPKIDLAGSS 445
Score = 54.3 bits (129), Expect = 1e-07
Identities = 22/65 (33%), Positives = 43/65 (66%)
Query: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
+R E++R+ ++ F + Q+ EL L+ GDI+ + EV++ W EG +G+ G+FP+N+++
Sbjct: 94 KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
Query: 94 VLPAD 98
L +
Sbjct: 154 ELSGE 158
Score = 42.7 bits (99), Expect = 4e-04
Identities = 23/73 (31%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 116 EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPR 175
EA+ ++ ++ + EL+ GE I IRK + W+EG+I GR+G+FP ++V+ ++
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKEM 60
Query: 176 LR--LCDDGPQLP 186
+ L + P+ P
Sbjct: 61 KKDPLTNKAPEKP 73
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 84.7 bits (208), Expect = 1e-16
Identities = 55/184 (29%), Positives = 96/184 (52%), Gaps = 13/184 (7%)
Query: 9 LGRRDFVYPSSTRDPSASNGGGSPARREE--KKRKAARLKFDFQAQSPKELTLQKGDIVY 66
+G + V+PS+ S G G+ + KK + A++ + A P++LTL G ++
Sbjct: 1043 VGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLIL 1102
Query: 67 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVL-EYGEAVA 119
I K+ W EGE R +G FPANYV++L P P +PP L + +
Sbjct: 1103 IRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIG 1162
Query: 120 QYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLR 177
Y + + EL+F KG+ I ++ K + +W++G + G+ G+FP++YV+++ +P +
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKLTTDMDPSQQ 1220
Query: 178 LCDD 181
C D
Sbjct: 1221 WCSD 1224
Score = 76.3 bits (186), Expect = 4e-14
Identities = 75/323 (23%), Positives = 140/323 (43%), Gaps = 30/323 (9%)
Query: 25 ASNGGGSPA----RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH 80
A+ G SP+ + E+ + A+ + ++A+ L K D++ + ++ D W GE
Sbjct: 896 ATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEV 954
Query: 81 HGRLGIFPANYVEVLP------------ADEIPKPIK----PPTYQVLEYGEAVAQYTFK 124
G+ G FP +YV+++ + E P +K P V+ E +A YT++
Sbjct: 955 QGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE 1014
Query: 125 GDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQ 184
+ +L+F++G+ + L+ K + +W+ G T + G+FP++YV++
Sbjct: 1015 SSEQGDLTFQQGD-VILVTKKDGDWWTG--TVGDKAGVFPSNYVRLKDSEGSGTAGKTGS 1071
Query: 185 LPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTP 244
L P + A ++ + P L + L + +P G+ + R + + +G
Sbjct: 1072 LGKKPEI-AQVIASYTATGPEQLTLAPGQLILIRKKNP--GGWWEGELQARGKKRQIGWF 1128
Query: 245 GPALSHSRGPSHPLDLGTSSP-NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQC 303
P T P +T+ MY Y QN+DEL +G ++V+ +
Sbjct: 1129 PANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE 1188
Query: 304 DDGWFVGVSRRTQKFGTFPGNYV 326
D W+ G + G FP NYV
Sbjct: 1189 DPDWWKG--EVNGQVGLFPSNYV 1209
Score = 63.9 bits (154), Expect = 2e-10
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 7/92 (7%)
Query: 24 SASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKE-VDKN------WL 76
+A G + + +E K R + F+++S E+T+Q GDIV + E VD++ WL
Sbjct: 726 TAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 77 EGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
GE G+ G FPANY E +P +E+P P+KP T
Sbjct: 786 GGELKGKTGWFPANYAEKIPENEVPAPVKPVT 817
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/182 (24%), Positives = 86/182 (47%), Gaps = 9/182 (4%)
Query: 19 STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG 78
S+ P++ SPA + + + +++ +LT Q+GD++ + K+ D +W G
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTG 1041
Query: 79 EHHGRLGIFPANYVEVLPADEIPKPIKPPTY-QVLEYGEAVAQYTFKGDLEVELSFRKGE 137
+ G+FP+NYV + ++ K + + E + +A YT G +L+ G+
Sbjct: 1042 TVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATG--PEQLTLAPGQ 1099
Query: 138 HICLIRKVNENWYEGRITGTGRQ---GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 194
I + +K W+EG + G++ G FPA+YV++ ++ P P S L A
Sbjct: 1100 LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEP--PKSTALAAV 1157
Query: 195 AR 196
+
Sbjct: 1158 CQ 1159
Score = 45.8 bits (107), Expect = 5e-05
Identities = 81/359 (22%), Positives = 130/359 (36%), Gaps = 79/359 (22%)
Query: 35 REEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE----------------- 77
+++K +A RLK Q + EL QK + +E DK WLE
Sbjct: 620 QKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 78 -------------GEHHGR------LG-IFPANYVEVLPADEIPKPIK---PPTYQVLEY 114
GE G+ LG +F + PA + P P T E
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 115 GEAV---AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT---------GRQGI 162
+ V A Y F+ E++ + G+ I V W + TG G+ G
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGD----IVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 163 FPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALR-SPADPIDLGGQTS 221
FPA+Y + E + P P + +A A +P+ L + ++P +
Sbjct: 796 FPANYAEKIPENEV----PAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWA 851
Query: 222 PRRTGFSFPTQEPRPQTQN---------LGTPGPALSHSRGPSHPLDLGTSSPNT----- 267
+ + T E +P+T N L P R P SSP+
Sbjct: 852 DFSSTWPTSTNE-KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG 910
Query: 268 SQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
++ +A+Y +R + ++ L + D + V++Q D WF V + G FP +YV
Sbjct: 911 EKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQK---GWFPKSYV 966
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 82.8 bits (203), Expect = 4e-16
Identities = 52/174 (29%), Positives = 92/174 (52%), Gaps = 11/174 (6%)
Query: 9 LGRRDFVYPSSTRDPSASNGGGSPARREE--KKRKAARLKFDFQAQSPKELTLQKGDIVY 66
+G + V+PS+ S G G+ + KK + A++ + A P++LTL G ++
Sbjct: 1043 VGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLIL 1102
Query: 67 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVL-EYGEAVA 119
I K+ W EGE R +G FPANYV++L P P +PP L + +
Sbjct: 1103 IRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIG 1162
Query: 120 QYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSRE 173
Y + + EL+F KG+ I ++ K + +W++G + G+ G+FP++YV+++ +
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV--NGQVGLFPSNYVKLTTD 1214
Score = 76.3 bits (186), Expect = 4e-14
Identities = 75/323 (23%), Positives = 140/323 (43%), Gaps = 30/323 (9%)
Query: 25 ASNGGGSPA----RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH 80
A+ G SP+ + E+ + A+ + ++A+ L K D++ + ++ D W GE
Sbjct: 896 ATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEV 954
Query: 81 HGRLGIFPANYVEVLP------------ADEIPKPIK----PPTYQVLEYGEAVAQYTFK 124
G+ G FP +YV+++ + E P +K P V+ E +A YT++
Sbjct: 955 QGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE 1014
Query: 125 GDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQ 184
+ +L+F++G+ + L+ K + +W+ G T + G+FP++YV++
Sbjct: 1015 SSEQGDLTFQQGD-VILVTKKDGDWWTG--TVGDKAGVFPSNYVRLKDSEGSGTAGKTGS 1071
Query: 185 LPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTP 244
L P + A ++ + P L + L + +P G+ + R + + +G
Sbjct: 1072 LGKKPEI-AQVIASYTATGPEQLTLAPGQLILIRKKNP--GGWWEGELQARGKKRQIGWF 1128
Query: 245 GPALSHSRGPSHPLDLGTSSP-NTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQC 303
P T P +T+ MY Y QN+DEL +G ++V+ +
Sbjct: 1129 PANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKE 1188
Query: 304 DDGWFVGVSRRTQKFGTFPGNYV 326
D W+ G + G FP NYV
Sbjct: 1189 DPDWWKG--EVNGQVGLFPSNYV 1209
Score = 63.9 bits (154), Expect = 2e-10
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 7/92 (7%)
Query: 24 SASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKE-VDKN------WL 76
+A G + + +E K R + F+++S E+T+Q GDIV + E VD++ WL
Sbjct: 726 TAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWL 785
Query: 77 EGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
GE G+ G FPANY E +P +E+P P+KP T
Sbjct: 786 GGELKGKTGWFPANYAEKIPENEVPAPVKPVT 817
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/182 (24%), Positives = 86/182 (47%), Gaps = 9/182 (4%)
Query: 19 STRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEG 78
S+ P++ SPA + + + +++ +LT Q+GD++ + K+ D +W G
Sbjct: 983 SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTG 1041
Query: 79 EHHGRLGIFPANYVEVLPADEIPKPIKPPTY-QVLEYGEAVAQYTFKGDLEVELSFRKGE 137
+ G+FP+NYV + ++ K + + E + +A YT G +L+ G+
Sbjct: 1042 TVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATG--PEQLTLAPGQ 1099
Query: 138 HICLIRKVNENWYEGRITGTGRQ---GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAA 194
I + +K W+EG + G++ G FPA+YV++ ++ P P S L A
Sbjct: 1100 LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEP--PKSTALAAV 1157
Query: 195 AR 196
+
Sbjct: 1158 CQ 1159
Score = 45.8 bits (107), Expect = 5e-05
Identities = 81/359 (22%), Positives = 130/359 (36%), Gaps = 79/359 (22%)
Query: 35 REEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLE----------------- 77
+++K +A RLK Q + EL QK + +E DK WLE
Sbjct: 620 QKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 78 -------------GEHHGR------LG-IFPANYVEVLPADEIPKPIK---PPTYQVLEY 114
GE G+ LG +F + PA + P P T E
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 115 GEAV---AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGT---------GRQGI 162
+ V A Y F+ E++ + G+ I V W + TG G+ G
Sbjct: 740 VKVVYYRALYPFESRSHDEITIQPGD----IVMVKGEWVDESQTGEPGWLGGELKGKTGW 795
Query: 163 FPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALR-SPADPIDLGGQTS 221
FPA+Y + E + P P + +A A +P+ L + ++P +
Sbjct: 796 FPANYAEKIPENEV----PAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWA 851
Query: 222 PRRTGFSFPTQEPRPQTQN---------LGTPGPALSHSRGPSHPLDLGTSSPNT----- 267
+ + T E +P+T N L P R P SSP+
Sbjct: 852 DFSSTWPTSTNE-KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG 910
Query: 268 SQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
++ +A+Y +R + ++ L + D + V++Q D WF V + G FP +YV
Sbjct: 911 EKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQK---GWFPKSYV 966
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 82.8 bits (203), Expect = 4e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 51 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 104
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 884 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 942
Query: 105 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 160
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 943 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 999
Query: 161 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 220
GIFP++YV+ + P + + S +P I +
Sbjct: 1000 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1056
Query: 221 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 280
+G+ + R + + G + GPS P I AMY
Sbjct: 1057 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1110
Query: 281 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1154
Score = 81.3 bits (199), Expect = 1e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 9 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 66
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 995 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1054
Query: 67 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 120
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1055 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1108
Query: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 178
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1109 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1166
Query: 179 CDDGPQLPT 187
C D L T
Sbjct: 1167 CADLQTLDT 1175
Score = 55.5 bits (132), Expect = 7e-08
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 34 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 85
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 720 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 779
Query: 86 IFPANYVEVLPADEIPKPIKP 106
FP NYVE +P+ E K + P
Sbjct: 780 WFPCNYVEKMPSSENEKAVSP 800
Score = 39.3 bits (90), Expect = 0.005
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 326
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 786
Score = 34.7 bits (78), Expect = 0.12
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1009
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 82.8 bits (203), Expect = 4e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 51 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 104
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 911 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 969
Query: 105 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 160
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 970 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 1026
Query: 161 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 220
GIFP++YV+ + P + + S +P I +
Sbjct: 1027 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1083
Query: 221 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 280
+G+ + R + + G + GPS P I AMY
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1137
Query: 281 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 81.3 bits (199), Expect = 1e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 9 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 66
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 1022 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1081
Query: 67 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 120
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1135
Query: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 178
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1136 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1193
Query: 179 CDDGPQLPT 187
C D L T
Sbjct: 1194 CADLQTLDT 1202
Score = 55.5 bits (132), Expect = 7e-08
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 34 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 85
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 747 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 806
Query: 86 IFPANYVEVLPADEIPKPIKP 106
FP NYVE +P+ E K + P
Sbjct: 807 WFPCNYVEKMPSSENEKAVSP 827
Score = 39.3 bits (90), Expect = 0.005
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 326
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 813
Score = 34.7 bits (78), Expect = 0.12
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 82.8 bits (203), Expect = 4e-16
Identities = 77/286 (26%), Positives = 115/286 (40%), Gaps = 25/286 (8%)
Query: 51 AQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEI----PKPI-- 104
A+ L K DI+ + E +NW GE HG G FP +YV+++P E+ P+ +
Sbjct: 911 AKKDNHLNFSKHDIITV-LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYA 969
Query: 105 ---KPPTYQVLEYGEA-VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQ 160
K PT GE +A Y + +L+F +GE I + +K E W+ G I R
Sbjct: 970 AVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTGSI--GDRS 1026
Query: 161 GIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQT 220
GIFP++YV+ + P + + S +P I +
Sbjct: 1027 GIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILI---L 1083
Query: 221 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQ 280
+G+ + R + + G + GPS P I AMY
Sbjct: 1084 KKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVI------AMYD 1137
Query: 281 YRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Y NEDEL +G ++VM + D W+ G G FP NYV
Sbjct: 1138 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 81.3 bits (199), Expect = 1e-15
Identities = 58/189 (30%), Positives = 97/189 (51%), Gaps = 18/189 (9%)
Query: 9 LGRRDFVYPSSTRDPS--ASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVY 66
+G R ++PS+ P S G S + KK + A++ + A ++L+L G ++
Sbjct: 1022 IGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLIL 1081
Query: 67 IHKEVDKNWLEGEHHGR-----LGIFPANYVEVL-PADEIPKPIKPPTYQVLEYGEAVAQ 120
I K+ W +GE R G FPA++V++L P+ E P P QV +A
Sbjct: 1082 ILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQV------IAM 1135
Query: 121 YTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS--REPRLRL 178
Y + + E ELSF KG+ I ++ K + +W++G I G G+FP++YV+++ +P +
Sbjct: 1136 YDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGV--TGLFPSNYVKMTTDSDPSQQW 1193
Query: 179 CDDGPQLPT 187
C D L T
Sbjct: 1194 CADLQTLDT 1202
Score = 55.5 bits (132), Expect = 7e-08
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 8/81 (9%)
Query: 34 RREEKKRKAA------RLKFDFQAQSPKELTLQKGDIVYIHKEV--DKNWLEGEHHGRLG 85
+ EEKKR+ A R + F+A++ E++ GDI+ + ++ + WL G G G
Sbjct: 747 KAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFG 806
Query: 86 IFPANYVEVLPADEIPKPIKP 106
FP NYVE +P+ E K + P
Sbjct: 807 WFPCNYVEKMPSSENEKAVSP 827
Score = 39.3 bits (90), Expect = 0.005
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYV 326
YRA+Y + +N DE+ GD + V ++ + GW G + FG FP NYV
Sbjct: 762 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQ--GNFGWFPCNYV 813
Score = 34.7 bits (78), Expect = 0.12
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
Y A+Y Y +L EG+ + V Q+ + W + R+ G FP NYV P
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 79.3 bits (194), Expect = 4e-15
Identities = 79/297 (26%), Positives = 117/297 (39%), Gaps = 83/297 (27%)
Query: 49 FQAQSPKELTLQKGDIVYIHKEVD-KNWLEGEHHGRLGIFPANYVEVLP----------- 96
++AQ EL+L GD+V + V + WL GE GR G+FP V+ +P
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 97 ---ADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
A P K P Q +++ + EL + GE + +I+++ + W+ G+
Sbjct: 69 PRCARRRGHPAKHPRPQ----RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK 124
Query: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
G+ G FP+++V+ L D GP S +P PS P P
Sbjct: 125 --KNGQLGAFPSNFVE--------LLDSGPP------------SLGNPDMPSVSPGPQRP 162
Query: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
P LS S P L T S H
Sbjct: 163 --------------------------------PKLSSLAYDSPPDYLQTVS------HPE 184
Query: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQC--DDGWFVGVSRRTQKFGTFPGNYVAP 328
YR ++ Y+P+ DEL LR GD V V+ + D GW+ G + + G FP N+V P
Sbjct: 185 VYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPDNFVLP 239
Score = 74.7 bits (182), Expect = 1e-13
Identities = 72/268 (26%), Positives = 118/268 (44%), Gaps = 56/268 (20%)
Query: 21 RDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH 80
R P + G PA+ +R ++ F + + EL LQ G+IV + KE++ W G+
Sbjct: 67 RRPRCARRRGHPAKHPRPQRWC-KVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
Query: 81 HGRLGIFPANYVEVLPA-----------DEIPKPIKPPTYQVL------EYGEAVAQ--- 120
+G+LG FP+N+VE+L + P P +PP L +Y + V+
Sbjct: 126 NGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEV 185
Query: 121 ----YTFKGDLEVELSFRKGEHICLIRKVNEN--WYEGRITGTGRQGIFPASYV------ 168
+ ++ + EL+ R+G+ + ++ K E+ W+EG GR+G+FP ++V
Sbjct: 186 YRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGEC--QGRRGVFPDNFVLPPPPI 243
Query: 169 -------QVSRE----PRLRLCDDGPQLPTSPRLTAA------ARSARHPSSPSALRSPA 211
VSRE + LPT +L A A+++R PS S +
Sbjct: 244 KKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSR 303
Query: 212 DPIDLGGQTSPRRTGFSFPTQEPRPQTQ 239
D GG S G S+ R +TQ
Sbjct: 304 DSGPNGGFQS----GGSYHPGRKRSKTQ 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,791,808
Number of Sequences: 37866
Number of extensions: 889632
Number of successful extensions: 5006
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 219
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 3682
Number of HSP's gapped (non-prelim): 1226
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.