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Search of human proteins with 63999048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63999048 syntaxin binding protein 4 [Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63999048 syntaxin binding protein 4 [Homo sapiens] 1077 0.0
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 60 5e-09
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 60 5e-09
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 60 5e-09
gi|148746189 multiple PDZ domain protein [Homo sapiens] 57 3e-08
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 54 4e-07
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 54 4e-07
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 54 4e-07
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 54 4e-07
gi|4759306 lin-7 homolog A [Homo sapiens] 54 4e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens] 54 5e-07
gi|8922944 lin-7 homolog C [Homo sapiens] 53 8e-07
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 52 1e-06
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 52 1e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 52 1e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 52 1e-06
gi|11545920 lin-7 homolog B [Homo sapiens] 52 2e-06
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 52 2e-06
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 52 2e-06
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 52 2e-06
gi|148612825 Rap GTPase interactor [Homo sapiens] 50 5e-06
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 50 5e-06
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 50 5e-06
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 50 5e-06
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 50 5e-06
gi|110611228 utrophin [Homo sapiens] 50 7e-06
gi|239047795 pleckstrin homology domain containing, family A mem... 49 9e-06
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 49 9e-06
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 49 9e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 49 9e-06
>gi|63999048 syntaxin binding protein 4 [Homo sapiens]
Length = 553
Score = 1077 bits (2785), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK 60
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK
Sbjct: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK 60
Query: 61 DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC 120
DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC
Sbjct: 61 DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC 120
Query: 121 TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT 180
TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
Sbjct: 121 TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT 180
Query: 181 SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR 240
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR
Sbjct: 181 SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR 240
Query: 241 QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL 300
QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL
Sbjct: 241 QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL 300
Query: 301 KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ 360
KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
Sbjct: 301 KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ 360
Query: 361 RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR 420
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR
Sbjct: 361 RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR 420
Query: 421 KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL 480
KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL
Sbjct: 421 KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL 480
Query: 481 ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN 540
ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN
Sbjct: 481 ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN 540
Query: 541 EEDCSRELPNQKS 553
EEDCSRELPNQKS
Sbjct: 541 EEDCSRELPNQKS 553
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 60.1 bits (144), Expect = 5e-09
Identities = 28/79 (35%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRLKPGDQLVS 72
L K+P +T+ K+ G+GL ++ + L +Y++ ++ GG DGRL GDQL+S
Sbjct: 1000 LRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLS 1059
Query: 73 VNKESMIGVSFEEAKSIIT 91
V+ S++G+S E A ++T
Sbjct: 1060 VDGRSLVGLSQERAAELMT 1078
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 60.1 bits (144), Expect = 5e-09
Identities = 28/79 (35%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRLKPGDQLVS 72
L K+P +T+ K+ G+GL ++ + L +Y++ ++ GG DGRL GDQL+S
Sbjct: 1001 LRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLS 1060
Query: 73 VNKESMIGVSFEEAKSIIT 91
V+ S++G+S E A ++T
Sbjct: 1061 VDGRSLVGLSQERAAELMT 1079
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 60.1 bits (144), Expect = 5e-09
Identities = 28/79 (35%), Positives = 48/79 (60%), Gaps = 1/79 (1%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRLKPGDQLVS 72
L K+P +T+ K+ G+GL ++ + L +Y++ ++ GG DGRL GDQL+S
Sbjct: 985 LRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLS 1044
Query: 73 VNKESMIGVSFEEAKSIIT 91
V+ S++G+S E A ++T
Sbjct: 1045 VDGRSLVGLSQERAAELMT 1063
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 57.4 bits (137), Expect = 3e-08
Identities = 33/92 (35%), Positives = 54/92 (58%), Gaps = 5/92 (5%)
Query: 8 VVSPSLLEKD---PAFQMITIAK-ETGLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDG 62
+ S S+ + D P + IT+ + GLG ++GG G L +Y++ + G +DG
Sbjct: 1941 LTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDG 2000
Query: 63 RLKPGDQLVSVNKESMIGVSFEEAKSIITGAK 94
RLK GDQ+++VN +S+ GV+ EEA +I+ K
Sbjct: 2001 RLKRGDQIIAVNGQSLEGVTHEEAVAILKRTK 2032
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/106 (33%), Positives = 57/106 (53%), Gaps = 12/106 (11%)
Query: 3 KNTSTVVSPSLLEKDPAF--------QMITIAK-ETGLGLKVLGGINRNEGPLVYIQEII 53
+NTS +P++ DPA I I+K TGLGL ++GG + G ++ I E+
Sbjct: 1602 RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII-IHEVY 1660
Query: 54 PGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSII--TGAKLRL 97
G KDGRL GDQ++ VN + + +EA +++ T ++RL
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
Score = 47.4 bits (111), Expect = 3e-05
Identities = 34/89 (38%), Positives = 50/89 (56%), Gaps = 6/89 (6%)
Query: 22 MITIAK-ETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIG 80
MI + K +GLGL + G +R+ V+I I P G KDGRL+ D+L+ +N + + G
Sbjct: 1350 MIELEKGHSGLGLSLAGNKDRSRMS-VFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
Query: 81 VSFEEAKSIITGAKLRLESAWEIAFIRQK 109
S + A SII A ++ +I FIR K
Sbjct: 1409 RSHQNASSIIKCAPSKV----KIIFIRNK 1433
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/67 (37%), Positives = 44/67 (65%), Gaps = 2/67 (2%)
Query: 30 GLGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESM-IGVSFEEAK 87
GLG V+G + N G L +++QEI G ++DGRLK DQ++++N +++ ++ ++A
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 88 SIITGAK 94
SI+ AK
Sbjct: 207 SILQKAK 213
Score = 45.8 bits (107), Expect = 1e-04
Identities = 32/94 (34%), Positives = 51/94 (54%), Gaps = 4/94 (4%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAKET-GLGLKVLGGINRNE--GPLVYIQEIIPGGDCY 59
++T V +P L + Q I + K + GLG +L + + ++ I+ ++PGG
Sbjct: 682 QSTEEVQAP-LAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAE 740
Query: 60 KDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
KDGRL PGD+L+ VN ++ S EEA + GA
Sbjct: 741 KDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/136 (27%), Positives = 65/136 (47%), Gaps = 14/136 (10%)
Query: 47 VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFI 106
V I+ + G DGRLK GDQ+++V+ E ++G E+ S++ AK+ ++ +
Sbjct: 1506 VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVK-------L 1558
Query: 107 RQKSDNIQPENLSCTSLI-EASGEYGPQASTLSLFSS----PPEILIPKTSSTPKTNNDI 161
++N P++ + S ASGE + +L + S P I SSTP
Sbjct: 1559 TIHAEN--PDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
Query: 162 LSSCEIKTGYNKTVQI 177
++C I G T++I
Sbjct: 1617 PATCPIIPGCETTIEI 1632
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/78 (32%), Positives = 46/78 (58%), Gaps = 4/78 (5%)
Query: 14 LEKDPAFQMITIAK-ETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVS 72
+ K+ + I IAK + LG+ V +G + ++ II GG +DGR+ GD ++S
Sbjct: 1000 VSKESFERTINIAKGNSSLGMTVSAN---KDGLGMIVRSIIHGGAISRDGRIAIGDCILS 1056
Query: 73 VNKESMIGVSFEEAKSII 90
+N+ES I V+ +A++++
Sbjct: 1057 INEESTISVTNAQARAML 1074
Score = 40.4 bits (93), Expect = 0.004
Identities = 24/70 (34%), Positives = 40/70 (57%), Gaps = 3/70 (4%)
Query: 30 GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSI 89
GLGL ++G RN+ V++ +I+ GG DGRL GDQ++ VN E + + E ++
Sbjct: 1735 GLGLSIVG--KRNDTG-VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAAL 1791
Query: 90 ITGAKLRLES 99
+ ++ L S
Sbjct: 1792 LKVSEGSLSS 1801
Score = 37.7 bits (86), Expect = 0.028
Identities = 18/62 (29%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 29 TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
+GLG ++GG + V ++ I+PGG + GRL GD ++ + + G+S E+
Sbjct: 265 SGLGFGIIGG----KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
Query: 89 II 90
++
Sbjct: 321 VL 322
Score = 34.3 bits (77), Expect = 0.31
Identities = 18/78 (23%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
Query: 15 EKDPAFQMITIAKETGLGLKVLG--GINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVS 72
E+ F + GLG+ + G G + E ++++ I DGR++ GDQ+++
Sbjct: 371 EESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
Query: 73 VNKESMIGVSFEEAKSII 90
V+ ++ G + ++A ++
Sbjct: 431 VDGTNLQGFTNQQAVEVL 448
Score = 33.9 bits (76), Expect = 0.40
Identities = 26/122 (21%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Query: 31 LGLKVLGGINRNEGPL-VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSI 89
LG+ + GG+ G + ++I + P G + +L+ GD++V++ S G++ +A ++
Sbjct: 1844 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1903
Query: 90 ITGA----KLRLESAWEIAFIRQKSDNIQPENLSCTSLIEAS---GEYG-PQASTLSLFS 141
+ A ++++ + +++ + +LS T L +S + G PQ +++L
Sbjct: 1904 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1963
Query: 142 SP 143
P
Sbjct: 1964 GP 1965
Score = 32.7 bits (73), Expect = 0.89
Identities = 15/65 (23%), Positives = 37/65 (56%), Gaps = 5/65 (7%)
Query: 26 AKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEE 85
++ +GLG+ + + + +I+ ++P G G+L GD+L+ VN +++G + ++
Sbjct: 560 SENSGLGISLEATVGHH-----FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQD 614
Query: 86 AKSII 90
+I+
Sbjct: 615 VVNIL 619
Score = 32.7 bits (73), Expect = 0.89
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 7/70 (10%)
Query: 31 LGLKVLGGINR----NEGPL---VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSF 83
LG+ ++GG + G + ++I+ ++ K+G LKPGD++V V+ + S
Sbjct: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
Query: 84 EEAKSIITGA 93
E+A I A
Sbjct: 1222 EQAVEAIRKA 1231
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKET--GLGLKVLGGINRNEGPL-VYIQEIIPGGD 57
++K S V SP + ++ + K+ GLG +++GG L ++I + PGG
Sbjct: 1077 LHKRWSIVSSP-----EREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 58 CYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
DG LKPGD+L+SVN S+ GVS A I+ A
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1167
Score = 40.4 bits (93), Expect = 0.004
Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 2 NKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVL-----GGIN---RNEGPLVYIQEII 53
NK S S + F++ + LG+ V GG+N R+ G +Y++ +I
Sbjct: 1349 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGG--IYVKAVI 1406
Query: 54 PGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
P G DGR+ GD++++VN S+ G + ++A
Sbjct: 1407 PQGAAESDGRIHKGDRVLAVNGVSLEGATHKQA 1439
Score = 37.4 bits (85), Expect = 0.036
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN----RNEGPLVYIQEIIPGGDC 58
K T+ V S + ++ F++ +GLG N + +V ++++ PG
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITG 92
+ G++ GD ++ VN S+ G+S +E S + G
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALRG 1581
Score = 34.7 bits (78), Expect = 0.23
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 6/74 (8%)
Query: 22 MITIAKET--GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMI 79
+IT+ K LG V G N+ Y+ ++I DGRLKPGD+L+ VN +
Sbjct: 1793 LITLIKSEKGSLGFTVTKG---NQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 80 GVSFEEAKSIITGA 93
++ +A +++ A
Sbjct: 1849 NMTHTDAVNLLRAA 1862
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKET--GLGLKVLGGINRNEGPL-VYIQEIIPGGD 57
++K S V SP + ++ + K+ GLG +++GG L ++I + PGG
Sbjct: 886 LHKRWSIVSSP-----EREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 940
Query: 58 CYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
DG LKPGD+L+SVN S+ GVS A I+ A
Sbjct: 941 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 976
Score = 46.6 bits (109), Expect = 6e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 2 NKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN---RNEGPLVYIQEIIPGGDC 58
NK S S + F++ + LG+ V GG+N R+ G +Y++ +IP G
Sbjct: 1158 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGG--IYVKAVIPQGAA 1215
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEA 86
DGR+ GD++++VN S+ G + ++A
Sbjct: 1216 ESDGRIHKGDRVLAVNGVSLEGATHKQA 1243
Score = 37.4 bits (85), Expect = 0.036
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN----RNEGPLVYIQEIIPGGDC 58
K T+ V S + ++ F++ +GLG N + +V ++++ PG
Sbjct: 1292 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1351
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITG 92
+ G++ GD ++ VN S+ G+S +E S + G
Sbjct: 1352 AESGKIDVGDVILKVNGASLKGLSQQEVISALRG 1385
Score = 34.7 bits (78), Expect = 0.23
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 6/74 (8%)
Query: 22 MITIAKET--GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMI 79
+IT+ K LG V G N+ Y+ ++I DGRLKPGD+L+ VN +
Sbjct: 1597 LITLIKSEKGSLGFTVTKG---NQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 80 GVSFEEAKSIITGA 93
++ +A +++ A
Sbjct: 1653 NMTHTDAVNLLRAA 1666
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKET--GLGLKVLGGINRNEGPL-VYIQEIIPGGD 57
++K S V SP + ++ + K+ GLG +++GG L ++I + PGG
Sbjct: 1077 LHKRWSIVSSP-----EREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 58 CYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
DG LKPGD+L+SVN S+ GVS A I+ A
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1167
Score = 46.6 bits (109), Expect = 6e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 2 NKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN---RNEGPLVYIQEIIPGGDC 58
NK S S + F++ + LG+ V GG+N R+ G +Y++ +IP G
Sbjct: 1349 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGG--IYVKAVIPQGAA 1406
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEA 86
DGR+ GD++++VN S+ G + ++A
Sbjct: 1407 ESDGRIHKGDRVLAVNGVSLEGATHKQA 1434
Score = 37.4 bits (85), Expect = 0.036
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN----RNEGPLVYIQEIIPGGDC 58
K T+ V S + ++ F++ +GLG N + +V ++++ PG
Sbjct: 1483 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1542
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITG 92
+ G++ GD ++ VN S+ G+S +E S + G
Sbjct: 1543 AESGKIDVGDVILKVNGASLKGLSQQEVISALRG 1576
Score = 34.7 bits (78), Expect = 0.23
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 6/74 (8%)
Query: 22 MITIAKET--GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMI 79
+IT+ K LG V G N+ Y+ ++I DGRLKPGD+L+ VN +
Sbjct: 1788 LITLIKSEKGSLGFTVTKG---NQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 80 GVSFEEAKSIITGA 93
++ +A +++ A
Sbjct: 1844 NMTHTDAVNLLRAA 1857
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 8/96 (8%)
Query: 1 MNKNTSTVVSPSLLEKDPAFQMITIAKET--GLGLKVLGGINRNEGPL-VYIQEIIPGGD 57
++K S V SP + ++ + K+ GLG +++GG L ++I + PGG
Sbjct: 1058 LHKRWSIVSSP-----EREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1112
Query: 58 CYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
DG LKPGD+L+SVN S+ GVS A I+ A
Sbjct: 1113 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNA 1148
Score = 46.6 bits (109), Expect = 6e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 2 NKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN---RNEGPLVYIQEIIPGGDC 58
NK S S + F++ + LG+ V GG+N R+ G +Y++ +IP G
Sbjct: 1330 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGG--IYVKAVIPQGAA 1387
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEA 86
DGR+ GD++++VN S+ G + ++A
Sbjct: 1388 ESDGRIHKGDRVLAVNGVSLEGATHKQA 1415
Score = 37.4 bits (85), Expect = 0.036
Identities = 23/94 (24%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGIN----RNEGPLVYIQEIIPGGDC 58
K T+ V S + ++ F++ +GLG N + +V ++++ PG
Sbjct: 1464 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1523
Query: 59 YKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITG 92
+ G++ GD ++ VN S+ G+S +E S + G
Sbjct: 1524 AESGKIDVGDVILKVNGASLKGLSQQEVISALRG 1557
Score = 34.7 bits (78), Expect = 0.23
Identities = 23/74 (31%), Positives = 38/74 (51%), Gaps = 6/74 (8%)
Query: 22 MITIAKET--GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMI 79
+IT+ K LG V G N+ Y+ ++I DGRLKPGD+L+ VN +
Sbjct: 1769 LITLIKSEKGSLGFTVTKG---NQRIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 80 GVSFEEAKSIITGA 93
++ +A +++ A
Sbjct: 1825 NMTHTDAVNLLRAA 1838
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/67 (44%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 28 ETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAK 87
+ GLG V+GG +N +YI IIPGG + G LK GDQL+SVN S+ G E+A
Sbjct: 115 DEGLGFNVMGGKEQNSP--IYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172
Query: 88 SIITGAK 94
++ AK
Sbjct: 173 ELLKAAK 179
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 53.5 bits (127), Expect = 5e-07
Identities = 41/136 (30%), Positives = 69/136 (50%), Gaps = 9/136 (6%)
Query: 4 NTSTVVSPSLLEKDPAFQMITIAKETG--LGLKVLGGINRNEGPL-VYIQEIIPGGDCYK 60
+T+ V SP L + +I + KE G LG + GG + G + ++++ I P G +
Sbjct: 568 STTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627
Query: 61 DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC 120
DGRLK GD+++ VN + G++F+EA I T ++R S + +R K + P C
Sbjct: 628 DGRLKEGDEILDVNGIPIKGLTFQEA--IHTFKQIR--SGLFVLTVRTKL--VSPSLTPC 681
Query: 121 TSLIEASGEYGPQAST 136
++ S P +T
Sbjct: 682 STPTHMSRSASPNFNT 697
Score = 52.0 bits (123), Expect = 1e-06
Identities = 25/75 (33%), Positives = 45/75 (60%), Gaps = 1/75 (1%)
Query: 20 FQMITIAKETGLGLKVLGGINRNEGP-LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESM 78
++M + + GLG++V GG P + + ++ GG ++DGRL GD+L+ +N +
Sbjct: 333 WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392
Query: 79 IGVSFEEAKSIITGA 93
+G+S EEA +I+ A
Sbjct: 393 VGLSHEEAVAILRSA 407
Score = 38.5 bits (88), Expect = 0.016
Identities = 25/101 (24%), Positives = 50/101 (49%), Gaps = 4/101 (3%)
Query: 15 EKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVN 74
E+D F ++ + +GLG V GG + E + + + G ++G + GD L+SVN
Sbjct: 2617 EEDVCFIVLNRKEGSGLGFSVAGGTD-VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675
Query: 75 KESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQP 115
S+ G++ ++ A+L ++ + I++ D +P
Sbjct: 2676 GASLAGLAHGNVLKVLHQAQLHKDA---LVVIKKGMDQPRP 2713
Score = 36.6 bits (83), Expect = 0.062
Identities = 20/63 (31%), Positives = 40/63 (63%), Gaps = 3/63 (4%)
Query: 30 GLGLKVLGGINR--NEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAK 87
GLGL + GG + +GPLV I+ + GG + G ++ GD+++++N + ++G+ +A
Sbjct: 2759 GLGLSLDGGKSSVTGDGPLV-IKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAW 2817
Query: 88 SII 90
+I+
Sbjct: 2818 NIM 2820
Score = 35.8 bits (81), Expect = 0.11
Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 2/78 (2%)
Query: 16 KDPAFQMITIAKE--TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSV 73
KD +T+ KE GLG+ N P +YI + PG + L GDQ++ V
Sbjct: 722 KDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEV 781
Query: 74 NKESMIGVSFEEAKSIIT 91
N ++ + + +I++
Sbjct: 782 NSVNVRHAALSKVHAILS 799
Score = 34.7 bits (78), Expect = 0.23
Identities = 31/145 (21%), Positives = 58/145 (40%), Gaps = 31/145 (21%)
Query: 32 GLKVLGGINR--NEGPL-----VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFE 84
G K GG R ++GP+ +++ E+ K G+++ D+++S+N + M+GV
Sbjct: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVD-- 154
Query: 85 EAKSIITGAKLRLESAWEIAFI-----------------RQKSDNIQPENLSCTSLIEAS 127
++GA E W FI S++ +P L + +
Sbjct: 155 -----VSGASYLAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLELGDRT 209
Query: 128 GEYGPQASTLSLFSSPPEILIPKTS 152
+ G + + S PP P+ S
Sbjct: 210 AKKGKRTRKFGVISRPPANKAPEES 234
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 52.8 bits (125), Expect = 8e-07
Identities = 29/67 (43%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 28 ETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAK 87
E GLG ++GG +N +YI IIPGG + G LK GDQL+SVN S+ G E+A
Sbjct: 100 EEGLGFNIMGGKEQNSP--IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157
Query: 88 SIITGAK 94
++ A+
Sbjct: 158 ELLKAAQ 164
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 52.4 bits (124), Expect = 1e-06
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 4 NTSTVVSPSLLEKDPAFQMITIAK--ETGLGLKVLGGINRNEGPL-VYIQEIIPGGDCYK 60
+T+ +V PS + I + K GLG ++GG + GP+ +Y++ I GG
Sbjct: 198 STAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAA 257
Query: 61 DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAK 94
DGRL+ GD+++ +N ESM G++ ++A AK
Sbjct: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAK 291
Score = 40.0 bits (92), Expect = 0.006
Identities = 29/123 (23%), Positives = 61/123 (49%), Gaps = 7/123 (5%)
Query: 8 VVSPSLLEKDPAFQMITIAKE--TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLK 65
V+ + L++ + + KE GLG + GG + E ++ + + P G ++G ++
Sbjct: 1099 VLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-ENKVITVHRVFPNGLASQEGTIQ 1157
Query: 66 PGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPE-NLSCTSLI 124
G++++S+N +S+ G + +A +I+ A+ E + R+ + P+ N S S
Sbjct: 1158 KGNEVLSINGKSLKGTTHHDALAILRQAR---EPRQAVIVTRKLTPEAMPDLNSSTDSAA 1214
Query: 125 EAS 127
AS
Sbjct: 1215 SAS 1217
Score = 33.9 bits (76), Expect = 0.40
Identities = 19/75 (25%), Positives = 39/75 (52%), Gaps = 10/75 (13%)
Query: 23 ITIAKETGLGLKVLGGINRNEGPL------VYIQEIIPGGDCYKDGRLKPGDQLVSVNKE 76
+++ KE G+GL GI P +++ + PG + DGRL+ GD++V ++
Sbjct: 356 VSLQKEAGVGL----GIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDS 411
Query: 77 SMIGVSFEEAKSIIT 91
+ ++ E +I++
Sbjct: 412 PVHCLTLNEVYTILS 426
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/64 (42%), Positives = 39/64 (60%), Gaps = 3/64 (4%)
Query: 30 GLGLKVLGGINRNEGP---LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG + GG+ P +Y+ +II GG KDGRL+ GD+L+ VN S+ V+ EEA
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210
Query: 87 KSII 90
+I+
Sbjct: 211 VAIL 214
Score = 47.4 bits (111), Expect = 3e-05
Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSV 73
LE +P +++ TGLG ++GG +G +++ I+ GG G L+ GDQ++SV
Sbjct: 312 LEGEPR-KVVLHKGSTGLGFNIVGG---EDGEGIFVSFILAGGPADLSGELQRGDQILSV 367
Query: 74 NKESMIGVSFEEAKSIITGA 93
N + G S E+A + + GA
Sbjct: 368 NGIDLRGASHEQAAAALKGA 387
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 20 FQMITIAK-ETGLGLKVLGGINR---NEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNK 75
F+ IT+ + +GLG + GG + + P ++I +IIPGG +DGRL+ D ++ VN+
Sbjct: 45 FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNE 104
Query: 76 ESMIGVSFEEA 86
+ VS +A
Sbjct: 105 VDVSEVSHSKA 115
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/64 (42%), Positives = 39/64 (60%), Gaps = 3/64 (4%)
Query: 30 GLGLKVLGGINRNEGP---LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG + GG+ P +Y+ +II GG KDGRL+ GD+L+ VN S+ V+ EEA
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366
Query: 87 KSII 90
+I+
Sbjct: 367 VAIL 370
Score = 47.4 bits (111), Expect = 3e-05
Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSV 73
LE +P +++ TGLG ++GG +G +++ I+ GG G L+ GDQ++SV
Sbjct: 520 LEGEPR-KVVLHKGSTGLGFNIVGG---EDGEGIFVSFILAGGPADLSGELQRGDQILSV 575
Query: 74 NKESMIGVSFEEAKSIITGA 93
N + G S E+A + + GA
Sbjct: 576 NGIDLRGASHEQAAAALKGA 595
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 20 FQMITIAK-ETGLGLKVLGGINR---NEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNK 75
F+ IT+ + +GLG + GG + + P ++I +IIPGG +DGRL+ D ++ VN+
Sbjct: 201 FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNE 260
Query: 76 ESMIGVSFEEA 86
+ VS +A
Sbjct: 261 VDVSEVSHSKA 271
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/64 (42%), Positives = 39/64 (60%), Gaps = 3/64 (4%)
Query: 30 GLGLKVLGGINRNEGP---LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG + GG+ P +Y+ +II GG KDGRL+ GD+L+ VN S+ V+ EEA
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261
Query: 87 KSII 90
+I+
Sbjct: 262 VAIL 265
Score = 47.4 bits (111), Expect = 3e-05
Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 14 LEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSV 73
LE +P +++ TGLG ++GG +G +++ I+ GG G L+ GDQ++SV
Sbjct: 415 LEGEPR-KVVLHKGSTGLGFNIVGG---EDGEGIFVSFILAGGPADLSGELQRGDQILSV 470
Query: 74 NKESMIGVSFEEAKSIITGA 93
N + G S E+A + + GA
Sbjct: 471 NGIDLRGASHEQAAAALKGA 490
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 20 FQMITIAK-ETGLGLKVLGGINR---NEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNK 75
F+ IT+ + +GLG + GG + + P ++I +IIPGG +DGRL+ D ++ VN+
Sbjct: 96 FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNE 155
Query: 76 ESMIGVSFEEA 86
+ VS +A
Sbjct: 156 VDVSEVSHSKA 166
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/67 (40%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 28 ETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAK 87
+ GLG ++GG +N +YI +IPGG + G LK GDQL+SVN S+ G E+A
Sbjct: 100 DEGLGFNIMGGKEQNSP--IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
Query: 88 SIITGAK 94
++ A+
Sbjct: 158 ELLKAAQ 164
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/59 (45%), Positives = 39/59 (66%), Gaps = 2/59 (3%)
Query: 30 GLGLKVLGGINRNEGPL--VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG+ + G +R G ++I+ II GG +KDGRL+ DQL++VN ES++G S EA
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEA 566
Score = 42.4 bits (98), Expect = 0.001
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 1/66 (1%)
Query: 30 GLGLKVLGGINRNEGP-LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
GLG V+ + GP ++++ I+P G KDGRL+ GD+++ VN + G + EE +
Sbjct: 392 GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
Query: 89 IITGAK 94
++ K
Sbjct: 452 MLRSTK 457
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/59 (45%), Positives = 39/59 (66%), Gaps = 2/59 (3%)
Query: 30 GLGLKVLGGINRNEGPL--VYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG+ + G +R G ++I+ II GG +KDGRL+ DQL++VN ES++G S EA
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEA 566
Score = 42.4 bits (98), Expect = 0.001
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 1/66 (1%)
Query: 30 GLGLKVLGGINRNEGP-LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
GLG V+ + GP ++++ I+P G KDGRL+ GD+++ VN + G + EE +
Sbjct: 392 GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVA 451
Query: 89 IITGAK 94
++ K
Sbjct: 452 MLRSTK 457
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/272 (24%), Positives = 110/272 (40%), Gaps = 50/272 (18%)
Query: 193 VASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLG--IQPTKEQHQALRQQVQADSKGT 250
+A+ E L +K+S + R +++ L I +++ Q+L+ Q+ A KG
Sbjct: 254 IANLQNEVAELSQKVSETTTSRQNEKEISQKCQVLDEDIDAKQKEIQSLKSQISALQKGY 313
Query: 251 VSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKE 310
+ C L E N + N E E LK RD+A+
Sbjct: 314 ----------SKVLCQTLSERNSEITSLKN---------------EGENLK--RDNAITS 346
Query: 311 --VNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHL--AEAAQRQAHGM 366
V++L++ +L D+Q +QL EE+ ++K + K + AL SR + E Q AH
Sbjct: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQEDAHR- 405
Query: 367 EMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEAS 426
L EA+ ELK K +QD++K + L +LRKS + +
Sbjct: 406 --------ELREAQEKELKL--------CKTQIQDMEKEMKKLRAELRKSCTEQSVISRT 449
Query: 427 TEKLLHFVEAIQEVFSDNSTPLSNLSERRAVL 458
+ E +QE L + R +V+
Sbjct: 450 LREKSKVEEKLQEDSRRKLLQLQEMGNRESVI 481
Score = 43.1 bits (100), Expect = 7e-04
Identities = 42/213 (19%), Positives = 84/213 (39%), Gaps = 16/213 (7%)
Query: 240 RQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMER 299
+ Q +G + +++ RN L+E E+ ++L Q S E R
Sbjct: 677 QNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLAQQKKALAKSITQEKNR 736
Query: 300 LKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAA 359
+K ++ V L+E+L +Q++ L + + K++AK + E+
Sbjct: 737 VKEALEEEQTRVQELEERLA---RQKEVLESSIAHEKRKAKEAL-------------ESE 780
Query: 360 QRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMA 419
+R+ +E + + E+ I K + + ++ K+ VQDL+ R+ +L E
Sbjct: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
Query: 420 RKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLS 452
L VE Q+ + S +L+
Sbjct: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLA 873
Score = 32.3 bits (72), Expect = 1.2
Identities = 39/192 (20%), Positives = 82/192 (42%), Gaps = 24/192 (12%)
Query: 293 EADEMERLKCERDDAL-----KEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETR 347
E +E ++++ E++ L KE++ LKEK+ + ++ EL+ +++ +A E+ R
Sbjct: 1031 ELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRASQEKHR 1090
Query: 348 ALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSD--------QNKESV 399
+++ + + + D I + + + +SD +++E +
Sbjct: 1091 L---QLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQSFSDLGVRCKGSRHEEVI 1147
Query: 400 QDLKKRIMVLDCQLRKSEMARKTFEASTE-------KLLHFVEAIQEVFSDNSTPLSNLS 452
Q KK + L ++++ E AR + K L +Q++ D L LS
Sbjct: 1148 QRQKKALSELRARIKELEKARSPDHKDHQNESFLDLKNLRMENNVQKILLDAKPDLPTLS 1207
Query: 453 ERRAVLASQTSL 464
R +LA Q L
Sbjct: 1208 -RIEILAPQNGL 1218
>gi|148612825 Rap GTPase interactor [Homo sapiens]
Length = 1075
Score = 50.1 bits (118), Expect = 5e-06
Identities = 26/71 (36%), Positives = 45/71 (63%), Gaps = 3/71 (4%)
Query: 29 TGLGLKVLGGINRNEG-PLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAK 87
+GLG+ ++ G++ + G P +YIQ ++PG DGRL GD+++ VN S++G+ + A
Sbjct: 984 SGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAV 1043
Query: 88 SIIT--GAKLR 96
+I G K+R
Sbjct: 1044 DLIRHGGKKMR 1054
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/60 (45%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 30 GLGLKVLGGINRNEGP---LVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
GLG + GGI P +YI +II GG KDGRL+ GD+L++VN ++ V EEA
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
Score = 40.0 bits (92), Expect = 0.006
Identities = 20/65 (30%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 29 TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
TGLG ++GG +G +++ I+ GG G L+ GD+++SVN ++ + E+A +
Sbjct: 394 TGLGFNIVGG---EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAA 450
Query: 89 IITGA 93
+ A
Sbjct: 451 ALKRA 455
Score = 38.5 bits (88), Expect = 0.016
Identities = 20/50 (40%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Query: 29 TGLGLKVLGGINRN---EGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNK 75
+GLG + GGI+ + P ++I +IIPGG DGRL D ++ VN+
Sbjct: 139 SGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNE 188
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 27 KETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
KETG G ++LGG G +YI I+P G DGRL+ GD+L+ V+ +IG S +
Sbjct: 847 KETGFGFRILGG--NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 904
Query: 87 KSIITGA----KLRLESAWEIAFIRQKSDNIQPENLS 119
++ A + L ++ F K++N P S
Sbjct: 905 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/100 (31%), Positives = 49/100 (49%)
Query: 444 NSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWE 503
NS+ ++ E+ +T+L P+ + + P T + + A ++ LP WE
Sbjct: 248 NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWE 307
Query: 504 EAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEED 543
AYT +G YFI+H T+TTSW+ P EE E+D
Sbjct: 308 MAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDD 347
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 30 GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA--- 86
G G V+GG +E + I+ ++ G DG+++ GD +VSVN ++G + +
Sbjct: 481 GFGFTVVGGDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 87 -KSIITGAKLRLE 98
+SI GA + LE
Sbjct: 539 FQSIPIGASVDLE 551
Score = 30.8 bits (68), Expect = 3.4
Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 18/99 (18%)
Query: 6 STVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVY-----------IQEIIP 54
STVV P +E I + G G ++ ++R E + I II
Sbjct: 991 STVVQPYDVE-------IRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIE 1043
Query: 55 GGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
G + G+LK GD++++VN S+ S + ++I A
Sbjct: 1044 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1082
Score = 30.0 bits (66), Expect = 5.8
Identities = 12/55 (21%), Positives = 28/55 (50%)
Query: 498 LPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQK 552
LP GWE+ Y+++H+ + T + +PV+ + E+ ++ ++ Q+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQ 415
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 27 KETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
KETG G ++LGG G +YI I+P G DGRL+ GD+L+ V+ +IG S +
Sbjct: 819 KETGFGFRILGG--NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
Query: 87 KSIITGA----KLRLESAWEIAFIRQKSDNIQPENLS 119
++ A + L ++ F K++N P S
Sbjct: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 913
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/100 (31%), Positives = 49/100 (49%)
Query: 444 NSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWE 503
NS+ ++ E+ +T+L P+ + + P T + + A ++ LP WE
Sbjct: 248 NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWE 307
Query: 504 EAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEED 543
AYT +G YFI+H T+TTSW+ P EE E+D
Sbjct: 308 MAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDD 347
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 30 GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA--- 86
G G V+GG +E + I+ ++ G DG+++ GD +VSVN ++G + +
Sbjct: 481 GFGFTVVGGDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 87 -KSIITGAKLRLE 98
+SI GA + LE
Sbjct: 539 FQSIPIGASVDLE 551
Score = 31.2 bits (69), Expect = 2.6
Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 17/98 (17%)
Query: 6 STVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVY----------IQEIIPG 55
STVV P +E I + G G ++ ++R E + I II G
Sbjct: 963 STVVQPYDVE-------IRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEG 1015
Query: 56 GDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
+ G+LK GD++++VN S+ S + ++I A
Sbjct: 1016 SPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1053
Score = 30.0 bits (66), Expect = 5.8
Identities = 12/55 (21%), Positives = 28/55 (50%)
Query: 498 LPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQK 552
LP GWE+ Y+++H+ + T + +PV+ + E+ ++ ++ Q+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQ 415
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 6/97 (6%)
Query: 27 KETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
KETG G ++LGG G +YI I+P G DGRL+ GD+L+ V+ +IG S +
Sbjct: 847 KETGFGFRILGG--NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 904
Query: 87 KSIITGA----KLRLESAWEIAFIRQKSDNIQPENLS 119
++ A + L ++ F K++N P S
Sbjct: 905 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/100 (31%), Positives = 49/100 (49%)
Query: 444 NSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMDCLPYGWE 503
NS+ ++ E+ +T+L P+ + + P T + + A ++ LP WE
Sbjct: 248 NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWE 307
Query: 504 EAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEED 543
AYT +G YFI+H T+TTSW+ P EE E+D
Sbjct: 308 MAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDD 347
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/73 (31%), Positives = 39/73 (53%), Gaps = 6/73 (8%)
Query: 30 GLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA--- 86
G G V+GG +E + I+ ++ G DG+++ GD +VSVN ++G + +
Sbjct: 481 GFGFTVVGGDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
Query: 87 -KSIITGAKLRLE 98
+SI GA + LE
Sbjct: 539 FQSIPIGASVDLE 551
Score = 31.2 bits (69), Expect = 2.6
Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 17/98 (17%)
Query: 6 STVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVY----------IQEIIPG 55
STVV P +E I + G G ++ ++R E + I II G
Sbjct: 991 STVVQPYDVE-------IRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEG 1043
Query: 56 GDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGA 93
+ G+LK GD++++VN S+ S + ++I A
Sbjct: 1044 SPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1081
Score = 30.0 bits (66), Expect = 5.8
Identities = 12/55 (21%), Positives = 28/55 (50%)
Query: 498 LPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPNQK 552
LP GWE+ Y+++H+ + T + +PV+ + E+ ++ ++ Q+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQ 415
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 49.7 bits (117), Expect = 7e-06
Identities = 55/229 (24%), Positives = 99/229 (43%), Gaps = 27/229 (11%)
Query: 337 QEAKAVVEETRALRSRIHLA--EAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQ 394
Q +A E R L+S+ L E AQ+ A M EV E+ + + + D+
Sbjct: 2630 QPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES-LNAVTSNWQKQVDK 2688
Query: 395 NKESVQDLKKRIMVLDCQLRKSEMARK-----------TFEASTEKLLHFVEAIQEV--- 440
E ++DL+ + LD ++++E R + + EK++ F E I +
Sbjct: 2689 ALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFK 2748
Query: 441 ---FSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLALESKELVKSVRALLDMD- 496
+D S+ LS L ++ S+ L L + + ++ K+L ++ R
Sbjct: 2749 VKTVNDLSSQLSPLDLHPSLKMSR-QLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQ 2807
Query: 497 -----CLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN 540
+ W+ + + + + Y+INH TQTT W HP M+ L S ++ N
Sbjct: 2808 HFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLN 2856
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/256 (21%), Positives = 109/256 (42%), Gaps = 31/256 (12%)
Query: 243 VQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERLKC 302
VQA + +F ++Q A V V A N L +L + + +M+ ++
Sbjct: 2445 VQASRRDLENFLKWIQEAETTV-----NVLVDASHRENALQDSILARELKQ--QMQDIQA 2497
Query: 303 ERD---DALKEVNTLKEKLLES---DKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLA 356
E D D K ++ ++K++++ ++ L L ++ Q + ++ ++R+ +
Sbjct: 2498 EIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHL--- 2554
Query: 357 EAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKS 416
EA+ + + + M EE+I+ L K ELK Q+ D + L Q
Sbjct: 2555 EASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGD------------VPALQLQYDHC 2602
Query: 417 EMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPA 476
+ R+ + +L+ V+ + +D P+ E R L S+T LTP R + I
Sbjct: 2603 KALRRELKEKEYSVLNAVDQARVFLADQ--PIEAPEEPRRNLQSKTELTPEER-AQKIAK 2659
Query: 477 TLALESKELVKSVRAL 492
+ +S E+ + +L
Sbjct: 2660 AMRKQSSEVKEKWESL 2675
Score = 31.6 bits (70), Expect = 2.0
Identities = 35/139 (25%), Positives = 59/139 (42%), Gaps = 15/139 (10%)
Query: 225 NYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDS 284
N LG+ P E +A + + S DFVQ + F + V + L++
Sbjct: 847 NLLGLHPKIEMARASCSALMSQP----SAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLEN 902
Query: 285 QLLPCDSSEADEMERLKCERD-------DALKEVNTLKE--KLLESDKQRKQLTEELQNV 335
+L +E LK +D A +N L + K+ ++ +++K L E L+N
Sbjct: 903 ELKGQPGHAY--LETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ 960
Query: 336 KQEAKAVVEETRALRSRIH 354
K + EET+AL +H
Sbjct: 961 KPALHKLAEETKALEKNVH 979
Score = 30.0 bits (66), Expect = 5.8
Identities = 42/172 (24%), Positives = 71/172 (41%), Gaps = 21/172 (12%)
Query: 297 MERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQN----VKQEAKAVVEETRALRSR 352
+E+ + ER E+N + L+E + TEE++N V E K V + L +
Sbjct: 734 LEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERK 793
Query: 353 IHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQ 412
I L E ++ + E+VI+ E + +++ S Q+ S++D +R +
Sbjct: 794 IQLQEDINAYFKQLD-ELEKVIKTKEEWVKH--TSISESSRQSLPSLKDSCQRELTNLLG 850
Query: 413 LR-KSEMARKTFEA-------------STEKLLHFVEAIQEVFSDNSTPLSN 450
L K EMAR + A + L +A+QE D L N
Sbjct: 851 LHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLEN 902
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 49.3 bits (116), Expect = 9e-06
Identities = 25/53 (47%), Positives = 31/53 (58%), Gaps = 4/53 (7%)
Query: 498 LPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEENEEDCSRELPN 550
LP GWEE +T +G YFI+H QTT++ HPV S EN E +E PN
Sbjct: 56 LPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQF----SPENSEFILQEEPN 104
Score = 33.9 bits (76), Expect = 0.40
Identities = 14/37 (37%), Positives = 19/37 (51%)
Query: 491 ALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHP 527
A + D LP W DG +FIN + T+W+HP
Sbjct: 4 ATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHP 40
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 49.3 bits (116), Expect = 9e-06
Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 38/176 (21%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAK----ETGLGLKVLGGINRNEGP---LVYIQEIIPG 55
K ++V ++ + P + + K GLG + GG+ P +Y+ +II G
Sbjct: 181 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240
Query: 56 GDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQP 115
G +KDGRL+ GD++++VN + V E+A + L++ +++ +++
Sbjct: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVA-------ALKNTYDVVYLKVAK----- 288
Query: 116 ENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGY 171
P + LS +PP+I TS + +N+I S + T Y
Sbjct: 289 ----------------PSNAYLSDSYAPPDI---TTSYSQHLDNEISHSSYLGTDY 325
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/93 (30%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 4 NTSTVVSPSL------LEKDPAFQMITIAK-ETGLGLKVLGGINR---NEGPLVYIQEII 53
NT T+ +P E + ++ IT+ + +GLG + GG + + P ++I +II
Sbjct: 84 NTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKII 143
Query: 54 PGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
PGG +DGRL+ D ++ VN+ + V+ A
Sbjct: 144 PGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 176
Score = 42.7 bits (99), Expect = 9e-04
Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 29 TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
TGLG ++GG +G ++I I+ GG G L+ GDQ++SVN + S E+A
Sbjct: 364 TGLGFNIVGG---EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 89 IITGA 93
+ A
Sbjct: 421 ALKNA 425
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 49.3 bits (116), Expect = 9e-06
Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 38/176 (21%)
Query: 3 KNTSTVVSPSLLEKDPAFQMITIAK----ETGLGLKVLGGINRNEGP---LVYIQEIIPG 55
K ++V ++ + P + + K GLG + GG+ P +Y+ +II G
Sbjct: 135 KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 194
Query: 56 GDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQP 115
G +KDGRL+ GD++++VN + V E+A + L++ +++ +++
Sbjct: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVA-------ALKNTYDVVYLKVAK----- 242
Query: 116 ENLSCTSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGY 171
P + LS +PP+I TS + +N+I S + T Y
Sbjct: 243 ----------------PSNAYLSDSYAPPDI---TTSYSQHLDNEISHSSYLGTDY 279
Score = 47.4 bits (111), Expect = 3e-05
Identities = 28/90 (31%), Positives = 50/90 (55%), Gaps = 7/90 (7%)
Query: 4 NTSTVVSPSLL---EKDPAFQMITIAK-ETGLGLKVLGGINR---NEGPLVYIQEIIPGG 56
NT T+ +P + E + ++ IT+ + +GLG + GG + + P ++I +IIPGG
Sbjct: 41 NTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGG 100
Query: 57 DCYKDGRLKPGDQLVSVNKESMIGVSFEEA 86
+DGRL+ D ++ VN+ + V+ A
Sbjct: 101 AAAQDGRLRVNDSILFVNEVDVREVTHSAA 130
Score = 42.7 bits (99), Expect = 9e-04
Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 3/65 (4%)
Query: 29 TGLGLKVLGGINRNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKS 88
TGLG ++GG +G ++I I+ GG G L+ GDQ++SVN + S E+A
Sbjct: 318 TGLGFNIVGG---EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 89 IITGA 93
+ A
Sbjct: 375 ALKNA 379
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 49.3 bits (116), Expect = 9e-06
Identities = 56/227 (24%), Positives = 96/227 (42%), Gaps = 20/227 (8%)
Query: 209 LNPSVRFKAEKLEMALNYLGIQPTKEQHQALRQQVQADSKGTVSFGDFVQVARNLFCLQL 268
+ S R K E E ++ + R+Q+ + D + LF Q+
Sbjct: 1879 MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQI 1938
Query: 269 DEVNVGAHEISNILDSQLLPCDSSEADEME----RLKCERDDALKEVNTLKEKLLESDKQ 324
E +I + L+ +LL C S+ E+E +++ ER+ ++ +K + ++Q
Sbjct: 1939 QEKT----DIIDRLEQELL-CASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
Query: 325 RKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEE-VIRLLEAKITE 383
Q TE+L K E + E+ R + Q+Q +E+D EE V R +E + E
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVR---------DDLQKQVKALEIDVEEQVSRFIELE-QE 2043
Query: 384 LKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMARKTFEASTEKL 430
+L D QN+ + L+K LD Q E R F+ +KL
Sbjct: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKL 2090
Score = 44.7 bits (104), Expect = 2e-04
Identities = 41/182 (22%), Positives = 85/182 (46%), Gaps = 26/182 (14%)
Query: 295 DEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIH 354
+++E+ + E ++ +EV L +L + Q+K+ T LQ ++QE K ++ L I
Sbjct: 2210 EQLEQFREELENKNEEVQQLHMQL---EIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2266
Query: 355 LAEAAQRQ-AHGMEMDYEEVIRLLEAKITELKAQLADYSDQNK------------ESVQD 401
++A Q H + + ++I+ E +I +L Q+ Q K E ++D
Sbjct: 2267 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2326
Query: 402 LKKRIMVLDCQLRKSEMARKTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQ 461
L+ +I +C + E ++ E E+L +E +Q+ L+N+ ++ ++ A
Sbjct: 2327 LETQI---ECLMSDQECVKRNREEEIEQLNEVIEKLQQ-------ELANIGQKTSMNAHS 2376
Query: 462 TS 463
S
Sbjct: 2377 LS 2378
Score = 35.4 bits (80), Expect = 0.14
Identities = 40/181 (22%), Positives = 81/181 (44%), Gaps = 30/181 (16%)
Query: 272 NVGAHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLLESDKQRKQLTEE 331
N+G H Q+ + + ++E ++ E+D+ + + N L +LE K K L +
Sbjct: 658 NLGIH-----YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQL---ILEISKL-KDLQQS 708
Query: 332 LQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAKITELKAQLADY 391
L N K E + + L+ I + +++ +E + +E+ +LK +L +
Sbjct: 709 LVNSKSEEMTL--QINELQKEIEILRQEEKEKGTLEQEVQEL---------QLKTELLE- 756
Query: 392 SDQNKESVQDLKKRIMVLDCQLRKSEMARKTFE--------ASTEKLLHFVEAIQEVFSD 443
Q KE DL+++ L+ + + +KT E S E+ L F+++I+ D
Sbjct: 757 -KQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815
Query: 444 N 444
+
Sbjct: 816 S 816
Score = 35.4 bits (80), Expect = 0.14
Identities = 35/159 (22%), Positives = 77/159 (48%), Gaps = 10/159 (6%)
Query: 266 LQLDEVNVG------AHEISNILDSQLLPCDSSEADEMERLKCERDDALKEVNTLKEKLL 319
LQ + N+G AH +S DS D A+++ L+ + + A +E+ +K L
Sbjct: 2359 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA-LEQQVETANEEMTFMKNVLK 2417
Query: 320 ESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEA 379
E++ + QLT+EL ++K+E ++V + + +++A + + + E V+
Sbjct: 2418 ETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD---KPELEVVLTEDAL 2474
Query: 380 KITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEM 418
K E + + + K S+ +L+ R++ L+ + ++
Sbjct: 2475 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2513
Score = 31.6 bits (70), Expect = 2.0
Identities = 35/148 (23%), Positives = 68/148 (45%), Gaps = 37/148 (25%)
Query: 290 DSSEADEMERLKCERDDALKEVNT-----------LKEKLLESDKQRKQLTE-------- 330
++S +E++ E++ ++E+NT LK+KL +DK +L E
Sbjct: 317 ENSNKEEIQ----EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 331 ------ELQNVKQEAKAVVEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLE----AK 380
EL N KQ+ + EE + L + E Q++ H ++++ +E K
Sbjct: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTV---EELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 381 ITELKAQLAD-YSDQNKESVQDLKKRIM 407
+ +L+A+L + Y Q + Q+L ++ M
Sbjct: 430 LEQLRAELDEMYGQQIVQMKQELIRQHM 457
Score = 30.0 bits (66), Expect = 5.8
Identities = 29/139 (20%), Positives = 57/139 (41%), Gaps = 11/139 (7%)
Query: 299 RLKCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEA 358
RL+ + L+ ++ +L + + +L E KQEA ++ LR R+H
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
Query: 359 AQRQ-------AHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDC 411
A+ Q A G+ Y + L E +I E D D+ ++ + R+ L+
Sbjct: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQE----KTDIIDRLEQELLCASNRLQELEA 1964
Query: 412 QLRKSEMARKTFEASTEKL 430
+ ++ + R+ E +
Sbjct: 1965 EQQQIQEERELLSRQKEAM 1983
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,995,782
Number of Sequences: 37866
Number of extensions: 798937
Number of successful extensions: 5758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 312
Number of HSP's successfully gapped in prelim test: 518
Number of HSP's that attempted gapping in prelim test: 3515
Number of HSP's gapped (non-prelim): 2366
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.