Search of human proteins with 63025222

Search of human proteins with 63025222

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
         (390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|63025222 transforming growth factor, beta 1 [Homo sapiens]         804   0.0  
gi|4507465 transforming growth factor, beta 3 [Homo sapiens]          318   7e-87
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa...   313   2e-85
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ...   301   9e-82
gi|4885259 myostatin [Homo sapiens]                                   105   7e-23
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    96   6e-20
gi|4504699 inhibin beta A precursor [Homo sapiens]                     90   3e-18
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       82   8e-16
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...    80   4e-15
gi|13899338 activin beta E [Homo sapiens]                              79   7e-15
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...    75   1e-13
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]       70   4e-12
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    70   4e-12
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...    69   7e-12
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           69   9e-12
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...    68   1e-11
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...    68   1e-11
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...    68   1e-11
gi|110349792 growth differentiation factor 1 [Homo sapiens]            66   5e-11
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    63   4e-10
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]              63   4e-10
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...    62   9e-10
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...    60   3e-09
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...    60   3e-09
gi|153792495 growth differentiation factor 15 [Homo sapiens]           58   2e-08
gi|239757187 PREDICTED: similar to growth differentiation factor...    58   2e-08
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    57   4e-08
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    56   6e-08
gi|222352098 nodal precursor [Homo sapiens]                            52   1e-06
gi|7705308 growth differentiation factor 2 [Homo sapiens]              49   1e-05

>gi|63025222 transforming growth factor, beta 1 [Homo sapiens]
          Length = 390

 Score =  804 bits (2077), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 60
           MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
Sbjct: 1   MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 60

Query: 61  SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI 120
           SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
Sbjct: 61  SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI 120

Query: 121 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR 180
           YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
Sbjct: 121 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR 180

Query: 181 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT 240
           YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
Sbjct: 181 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT 240

Query: 241 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI 300
           TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
Sbjct: 241 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI 300

Query: 301 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA 360
           DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
Sbjct: 301 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA 360

Query: 361 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390
           LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Sbjct: 361 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390


>gi|4507465 transforming growth factor, beta 3 [Homo sapiens]
          Length = 412

 Score =  318 bits (814), Expect = 7e-87
 Identities = 190/410 (46%), Positives = 244/410 (59%), Gaps = 40/410 (9%)

Query: 15  LLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLP 74
           L+ L +L     +  LSTC T+D   +K+KR+EAIRGQILSKLRL SPP    +    +P
Sbjct: 9   LVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTH--VP 66

Query: 75  EAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE---THNEIYDKFKQ 126
             VLALYNSTR+    + GE  E   +   E++YYAKE+ +  M++    HNE+    K 
Sbjct: 67  YQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKG 126

Query: 127 STHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHVELYQKYSNNSW--- 179
            T  ++ F N S + +       L RAE R+LR+      + EQ +EL+Q    +     
Sbjct: 127 ITSKVFRF-NVSSVEK---NRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAK 182

Query: 180 -RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-------DSRDNT 231
            RY+  + L    + EWLSFDVT  VR+WL R     G  +S HC C       D  +N 
Sbjct: 183 QRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENI 242

Query: 232 LQV------DINGFTTGRRGDLATIHGM---NRPFLLLMATPLERAQH--LQSSRHRRAL 280
            +V       ++      RGDL  +      + P L+LM  P  R  +      R +RAL
Sbjct: 243 HEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRAL 302

Query: 281 DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVL 340
           DTNYCF + E+NCCVR LYIDFR+DLGWKW+HEPKGY+ANFC GPCPY+ S DT +S VL
Sbjct: 303 DTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVL 362

Query: 341 ALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390
            LYN  NP ASA+PCCVPQ LEPL I+YYVGR PKVEQLSNM+V+SCKCS
Sbjct: 363 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 412


>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  313 bits (801), Expect = 2e-85
 Identities = 183/402 (45%), Positives = 244/402 (60%), Gaps = 43/402 (10%)

Query: 27  AAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRD 86
           A  LSTC T+DM+   RKRIEAIRGQILSKL+L SPP +    P  +P  V+++YNSTRD
Sbjct: 18  ALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPP-EDYPEPEEVPPEVISIYNSTRD 76

Query: 87  ----RVAGESAEPEPE-PEADYYAKEVTRVLM---VETHNEIYDKFKQSTHSIYMFFNTS 138
               + +  +A  E E  + +YYAKEV ++ M     + N I   F +    I  F  ++
Sbjct: 77  LLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSA 136

Query: 139 ELREAVPEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAP 189
             + A      L +AE R+ RL   K +V EQ +ELYQ       ++ + RY+ ++++  
Sbjct: 137 MEKNASN----LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKT 192

Query: 190 SDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---D 235
               EWLSFDVT  V +WL       GF++S HC C            ++   L+     
Sbjct: 193 RAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG 252

Query: 236 INGFTTGRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSS 288
           I+G +T   GD  TI    +      P LLLM  P  R +  Q++R + RALD  YCF +
Sbjct: 253 IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRN 312

Query: 289 TEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNP 348
            + NCC+R LYIDF++DLGWKWIHEPKGY+ANFC G CPY+WS DTQ+S+VL+LYN  NP
Sbjct: 313 VQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINP 372

Query: 349 GASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 390
            ASA+PCCV Q LEPL I+YY+G+ PK+EQLSNMIV+SCKCS
Sbjct: 373 EASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 414


>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
           sapiens]
          Length = 442

 Score =  301 bits (770), Expect = 9e-82
 Identities = 183/429 (42%), Positives = 245/429 (57%), Gaps = 69/429 (16%)

Query: 27  AAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRD 86
           A  LSTC T+DM+   RKRIEAIRGQILSKL+L SPP +    P  +P  V+++YNSTRD
Sbjct: 18  ALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPP-EDYPEPEEVPPEVISIYNSTRD 76

Query: 87  ----RVAGESAEPEPE-PEADYYAKEVTRVLMV-----ETHNEIYDKFKQSTHSI----- 131
               + +  +A  E E  + +YYAKEV ++ M      ET   +      S  S+     
Sbjct: 77  LLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQS 136

Query: 132 --------------------YMFFNTSELREAVPEPVLLSRAELRLLRL---KLKV-EQH 167
                                + F+ S + +       L +AE R+ RL   K +V EQ 
Sbjct: 137 QVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASN---LVKAEFRVFRLQNPKARVPEQR 193

Query: 168 VELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAH 222
           +ELYQ       ++ + RY+ ++++      EWLSFDVT  V +WL       GF++S H
Sbjct: 194 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 253

Query: 223 CSC-----------DSRDNTLQV---DINGFTTGRRGDLATIHGMNR------PFLLLMA 262
           C C            ++   L+     I+G +T   GD  TI    +      P LLLM 
Sbjct: 254 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLML 313

Query: 263 TPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF 321
            P  R +  Q++R + RALD  YCF + + NCC+R LYIDF++DLGWKWIHEPKGY+ANF
Sbjct: 314 LPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANF 373

Query: 322 CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSN 381
           C G CPY+WS DTQ+S+VL+LYN  NP ASA+PCCV Q LEPL I+YY+G+ PK+EQLSN
Sbjct: 374 CAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSN 433

Query: 382 MIVRSCKCS 390
           MIV+SCKCS
Sbjct: 434 MIVKSCKCS 442


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score =  105 bits (262), Expect = 7e-23
 Identities = 99/359 (27%), Positives = 153/359 (42%), Gaps = 42/359 (11%)

Query: 42  KRKRIEAIRGQILSKLRLASPPSQGE------VPPGPLPEAVLALYNSTRDRVAGESAEP 95
           K  RIEAI+ QILSKLRL + P+  +      +P  P    ++  Y+  RD  +  S E 
Sbjct: 49  KSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLED 108

Query: 96  EPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAEL 155
           +     DY+A   T + M    + +     +     + F +  +  + V   + +    L
Sbjct: 109 D-----DYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIY---L 160

Query: 156 RLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPE---WLSFDVTGVVRQWLSRGG 212
           R +     V   +    K   +  RY   R L    +P    W S DV  V++ WL +  
Sbjct: 161 RPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPE 220

Query: 213 EIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQ 272
              G  + A    D   + L V   G      G+     G+N PFL +  T   +     
Sbjct: 221 SNLGIEIKA---LDENGHDLAVTFPG-----PGE----DGLN-PFLEVKVTDTPK----- 262

Query: 273 SSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSL 332
             R RR    +    STE  CC   L +DF    GW WI  PK Y AN+C G C +++  
Sbjct: 263 --RSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQ 319

Query: 333 DTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKCS 390
              ++    L +Q NP  SA PCC P  + P+ ++Y+ G++  +  ++  M+V  C CS
Sbjct: 320 KYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 375


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 97/365 (26%), Positives = 148/365 (40%), Gaps = 51/365 (13%)

Query: 45  RIEAIRGQILSKLRLASPPSQGE------VPPGPLPEAVLALYNSTRDRVAGESAEPEPE 98
           R+E+I+ QILSKLRL   P+         +P  P  + +L L++       G++ +PE  
Sbjct: 75  RLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHD-----FQGDALQPEDF 129

Query: 99  PEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFN-----TSELR-------EAVPE 146
            E D Y      V+ +    +   +   S    +  F+     T  L+         VP 
Sbjct: 130 LEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPR 189

Query: 147 PVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQ 206
           P  +    L++LRLK    +             R  S ++   S S  W S D   V+  
Sbjct: 190 PATVY---LQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHS 246

Query: 207 WLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLE 266
           W  +     G  ++A    D     L V   G   G  G    +H    PF+ L      
Sbjct: 247 WFRQPQSNWGIEINAF---DPSGTDLAVTSLG--PGAEG----LH----PFMELRVLE-- 291

Query: 267 RAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC 326
                 + R RR L  +    S+E  CC   L +DF    GW WI  PK Y AN+C G C
Sbjct: 292 -----NTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQC 345

Query: 327 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVR 385
            Y++     ++    L  Q NP  SA PCC P  + P+ ++Y+  ++  +  ++  M+V 
Sbjct: 346 EYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVD 402

Query: 386 SCKCS 390
            C CS
Sbjct: 403 RCGCS 407


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 111/441 (25%), Positives = 176/441 (39%), Gaps = 74/441 (16%)

Query: 6   LRLLPLLLPLLWLLVL---TPGR---------PAAGLSTCKTIDMELVKRKRIEAIRGQI 53
           L L   LL   W++V    TPG          P+  L+     D+   + + +EA++  I
Sbjct: 4   LWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPK-DVPNSQPEMVEAVKKHI 62

Query: 54  LSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLM 113
           L+ L L   P   +    P+P+A  AL N+ R    G+  E       D   +      +
Sbjct: 63  LNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNEL 116

Query: 114 VETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKLKVEQ 166
           +E  +EI    +  T    + F   E+ +   +  ++ RAE+ L        R + KV  
Sbjct: 117 MEQTSEIITFAESGTARKTLHF---EISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTI 173

Query: 167 HVELYQKYSNNSW----------------RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSR 210
            +   QK+   S                   L +  +  +    W  F V+  +++ L +
Sbjct: 174 RLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQ 233

Query: 211 GGEIEGFRLSAHCSCDS------------RDNTLQVDINGFTTGRRGDLATIHGMNRPFL 258
           G      R++     +S            ++   +    G   G  G        +RPFL
Sbjct: 234 GKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFL 293

Query: 259 LLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGY 317
           +L A   E   H    R RR L+ +         CC +Q ++ F KD+GW  WI  P GY
Sbjct: 294 MLQARQSEDHPH---RRRRRGLECD----GKVNICCKKQFFVSF-KDIGWNDWIIAPSGY 345

Query: 318 HANFCLGPCP-----YIWSLDTQYSKVLALYNQ--HNPGASAAPCCVPQALEPLPIVYY- 369
           HAN+C G CP        S  + +S V+  Y    H+P A+   CCVP  L P+ ++YY 
Sbjct: 346 HANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYD 405

Query: 370 VGRKPKVEQLSNMIVRSCKCS 390
            G+    + + NMIV  C CS
Sbjct: 406 DGQNIIKKDIQNMIVEECGCS 426


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 97/395 (24%), Positives = 154/395 (38%), Gaps = 59/395 (14%)

Query: 23  PGRPAAGLSTCKTI-------DMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPE 75
           PG P     TC +        ++  V    +EA++  ILS+L++   P+     P     
Sbjct: 45  PGSPGGSQDTCTSCGGFRRPEELGRVDGDFLEAVKRHILSRLQMRGRPNITHAVPKAAMV 104

Query: 76  AVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFF 135
             L   ++ + R  G    P  +  A   A    RV  + +  E  D    S   +Y F 
Sbjct: 105 TALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAET-DGLASSRVRLYFFI 163

Query: 136 NTSELREAVPE-----------PVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSN 184
           +    +                P +L +   R +R+K      V   ++   + W  +  
Sbjct: 164 SNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVK------VYFQEQGHGDRWNMVEK 217

Query: 185 RLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRR 244
           R+        W +F +T  ++    RG      RL+    CDS      V +     G  
Sbjct: 218 RVDLKRSG--WHTFPLTEAIQALFERGER----RLNLDVQCDSCQELAVVPVF-VDPGEE 270

Query: 245 GDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRK 304
                    +RPF+++ A        L  SRHR       C   T   CC +Q +IDFR 
Sbjct: 271 S--------HRPFVVVQA-------RLGDSRHRIRKRGLECDGRTNL-CCRQQFFIDFRL 314

Query: 305 DLGWK-WIHEPKGYHANFCLGPCP-YIWSLDTQYSKV-LALYNQH-----NPGASAAPCC 356
            +GW  WI  P GY+ N+C G CP Y+  +    S    A+ NQ+     NPG +   CC
Sbjct: 315 -IGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPG-TVNSCC 372

Query: 357 VPQALEPLPIVYYVGRKPKVEQ-LSNMIVRSCKCS 390
           +P  L  + ++Y+      V++ + NMIV  C C+
Sbjct: 373 IPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA 407


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 111/420 (26%), Positives = 172/420 (40%), Gaps = 70/420 (16%)

Query: 8   LLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRG--------QILSKLRL 59
           LL LLLP     VL  G  AAGL        EL +RK   A  G        ++LS+  L
Sbjct: 8   LLALLLPQ----VLLGG--AAGLVP------ELGRRKFAAASSGRPSSQPSDEVLSEFEL 55

Query: 60  ASPPSQG-EVPPGPLPEAVLALYN-STRDRVAGESAEPEPEPEADYYAKEVTRVLMVETH 117
                 G +  P P  +AV+  Y      R +G+   P P+   +  A     V     H
Sbjct: 56  RLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFH-H 114

Query: 118 NEIYDKFKQSTHSIY--MFFNTSELREAVPEPVLLSRAELRLLRLKLK--------VEQH 167
            E  ++  +++       FFN S    ++P    ++ AEL++ R +++            
Sbjct: 115 EESLEELPETSGKTTRRFFFNLS----SIPTEEFITSAELQVFREQMQDALGNNSSFHHR 170

Query: 168 VELYQ----KYSNNSW---RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLS 220
           + +Y+      +N+ +   R L  RL+  + S  W SFDVT  V +W ++G    GF + 
Sbjct: 171 INIYEIIKPATANSKFPVTRLLDTRLVNQNAS-RWESFDVTPAVMRWTAQGHANHGFVVE 229

Query: 221 -AHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMAT-----PLERAQHLQSS 274
            AH       +   V I+          + I    RP L+         PL + +  Q+ 
Sbjct: 230 VAHLEEKQGVSKRHVRISRSLHQDEHSWSQI----RPLLVTFGHDGKGHPLHKREKRQAK 285

Query: 275 RHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWS-- 331
             +R           + +C    LY+DF  D+GW  WI  P GYHA +C G CP+  +  
Sbjct: 286 HKQR--------KRLKSSCKRHPLYVDF-SDVGWNDWIVAPPGYHAFYCHGECPFPLADH 336

Query: 332 -LDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQLSNMIVRSCKC 389
              T ++ V  L N  N     A CCVP  L  + ++Y     K  ++   +M+V  C C
Sbjct: 337 LNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 56/162 (34%), Positives = 82/162 (50%), Gaps = 17/162 (10%)

Query: 237 NGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVR 296
           N   TG+   L    G  +PFL L      RA    + R RR   T  C  +T   CC R
Sbjct: 198 NSTVTGQPRRLLDTAGHQQPFLELKI----RANEPGAGRARRRTPT--CEPATPL-CCRR 250

Query: 297 QLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWS-----LDTQYSKVLALYNQHNPGA 350
             Y+DF+ +LGW+ WI +P+GY  N+C G CP   +       + +S V +L   +NP  
Sbjct: 251 DHYVDFQ-ELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWP 309

Query: 351 SAAPCCVPQALEPLPIVY--YVGRKPKVEQLSNMIVRSCKCS 390
           ++  CCVP A  PL ++Y  + G   K + + +M+V +C CS
Sbjct: 310 ASTSCCVPTARRPLSLLYLDHNGNVVKTD-VPDMVVEACGCS 350


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 76/303 (25%), Positives = 125/303 (41%), Gaps = 48/303 (15%)

Query: 121 YDK--FKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQH-VELYQK 173
           YDK    +  H     FN S+    +PE  +++ AE R+ +       K +   + +YQ 
Sbjct: 224 YDKEFSPRQRHHKEFKFNLSQ----IPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQV 279

Query: 174 YSNNSWR----YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRD 229
              +  R    +L +  +  +    WL FD+T     W+       G +LS      +RD
Sbjct: 280 LQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV----TRD 335

Query: 230 NTLQVDINGFTTGRRGDLATIHGMNRPFLL---------LMATPLERAQHLQSSRHRRAL 280
                       GR G         +PF++         +  T    ++  Q SR+R   
Sbjct: 336 GVHVHPRAAGLVGRDGPYD-----KQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQ 390

Query: 281 D---------TNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIW 330
                     ++Y  S  +  C   +LY+ F+ DLGW+ WI  PKGY AN+C G C +  
Sbjct: 391 SQDVARVSSASDYNSSELKTACRKHELYVSFQ-DLGWQDWIIAPKGYAANYCDGECSFPL 449

Query: 331 SLD---TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRS 386
           +     T ++ V  L +  NP     PCC P  L  + ++Y+      + ++  NM+VR+
Sbjct: 450 NAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRA 509

Query: 387 CKC 389
           C C
Sbjct: 510 CGC 512


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 72/281 (25%), Positives = 112/281 (39%), Gaps = 48/281 (17%)

Query: 144 VPEPVLLSRAELRL----LRLKLKVEQ-HVELYQKYSNNSWR-----YLSNRLLAPSDSP 193
           +PE   ++ AE R+    +R +   E   + +YQ    +  R      L +R L  S+  
Sbjct: 163 IPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASEEG 222

Query: 194 EWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGM 253
            WL FD+T     W+       G +LS         N     +     GR G        
Sbjct: 223 -WLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGL----IGRHGP-----QN 272

Query: 254 NRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKN--------------------C 293
            +PF++      E   H +S R   +   +   S T KN                    C
Sbjct: 273 KQPFMVAFFKATE--VHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQAC 330

Query: 294 CVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPY---IWSLDTQYSKVLALYNQHNPG 349
              +LY+ FR DLGW+ WI  P+GY A +C G C +    +   T ++ V  L +  NP 
Sbjct: 331 KKHELYVSFR-DLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPE 389

Query: 350 ASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
               PCC P  L  + ++Y+      + ++  NM+VR+C C
Sbjct: 390 TVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 105/401 (26%), Positives = 157/401 (39%), Gaps = 89/401 (22%)

Query: 46  IEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNS-TRDRVAGESAEPEPEPEADYY 104
           +++++ + L  L L+  P+Q      P PE +L LYN    DR +  SA           
Sbjct: 55  LQSMKDEFLKTLNLSDIPTQDSAKVDP-PEYMLELYNKFATDRTSMPSAN---------- 103

Query: 105 AKEVTRVLMVETHNEIYDKFKQST-----HSIYMFFNTSELREAVPEPVLLSRAELRLLR 159
                  ++    NE  D F Q           + FN S     +P    +  AELRL  
Sbjct: 104 -------IIRSFKNE--DLFSQPVSFNGLRKYPLLFNVS-----IPHHEEVIMAELRLYT 149

Query: 160 LKLK-------VEQHVELYQ----KYSNNSWRYLSNRLLAPSD-----SPEWLSFDVTGV 203
           L  +       V++ + +++    K  N   R   N L+  S      + EW +FDVT  
Sbjct: 150 LVQRDRMIYDGVDRKITIFEVLESKGDNEGER---NMLVLVSGEIYGTNSEWETFDVTDA 206

Query: 204 VRQWLSRGG---EIEGFRLSAHCSC-DSRDNTLQVDING----------FTTGRRGDLAT 249
           +R+W   G    ++E    S H    D+    L++D +           F+  +  D   
Sbjct: 207 IRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKER 266

Query: 250 IHGMNRPFLLLMATPLERA--QHLQSSRHRRAL---DTNYCFSSTEK-------NCCVRQ 297
              +N          L+        S     AL    +N  + ST +       N C R 
Sbjct: 267 KEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRT 326

Query: 298 -LYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWS---LDTQYSKVLALYNQHNPGASA 352
            LYIDF K++GW  WI  P GY A  C G C Y  +     T+++ + AL +  N   ++
Sbjct: 327 PLYIDF-KEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKAS 385

Query: 353 APCCVPQALEPLPIVY----YVGRKPKVEQLSNMIVRSCKC 389
             CCVP  LEP+ I+Y     V  K K E    M V  C C
Sbjct: 386 KACCVPTKLEPISILYLDKGVVTYKFKYE---GMAVSECGC 423


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 71/282 (25%), Positives = 119/282 (42%), Gaps = 51/282 (18%)

Query: 144 VPEPVLLSRAELRLLR-----------LKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDS 192
           +P    ++ AE R+ +           +K+ + Q ++ Y   + ++  +L +   A +  
Sbjct: 187 IPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYT--NRDADLFLLDTRKAQALD 244

Query: 193 PEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHG 252
             WL FD+T     W+       G +L A    D R  ++ V   G   GR+G  +    
Sbjct: 245 VGWLVFDITVTSNHWVINPQNNLGLQLCAETG-DGR--SINVKSAGLV-GRQGPQS---- 296

Query: 253 MNRPFLLLMATPLE-------------------RAQHLQSSRHRRALDTNYCFSSTEKNC 293
             +PF++      E                    + H  SSR     D N   +S +K  
Sbjct: 297 -KQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYN---TSEQKQA 352

Query: 294 CVR-QLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWSLD---TQYSKVLALYNQHNP 348
           C + +LY+ FR DLGW+ WI  P+GY A +C G C +  +     T ++ V  L +   P
Sbjct: 353 CKKHELYVSFR-DLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFP 411

Query: 349 GASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
                PCC P  L  + ++Y+      + ++  NM+VRSC C
Sbjct: 412 DHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 41/124 (33%), Positives = 66/124 (53%), Gaps = 14/124 (11%)

Query: 276 HRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCP-YIWSLD 333
           HRR +D         + CC ++ ++DFR ++GW  WI +P+GY  NFC+G CP +I  + 
Sbjct: 234 HRRGIDCQ----GGSRMCCRQEFFVDFR-EIGWHDWIIQPEGYAMNFCIGQCPLHIAGMP 288

Query: 334 ----TQYSKVLALYNQHNPGAS--AAPCCVPQALEPLPIVYYVGRKPKVE-QLSNMIVRS 386
               + ++ VL L   +    +     CCVP A  PL ++YY      V+  + +M+V +
Sbjct: 289 GIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEA 348

Query: 387 CKCS 390
           C CS
Sbjct: 349 CGCS 352


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 95/357 (26%), Positives = 143/357 (40%), Gaps = 57/357 (15%)

Query: 70  PGPLPEAVLALYNSTRDRVAGESAEPEPEP----EADYYAKEVTRVLMVET--HNEIYDK 123
           P P   AV+  Y   RD    +S E E E       +Y  +  +R   V +  H E  + 
Sbjct: 71  PQPSKSAVIPDY--MRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLEN 128

Query: 124 FK-QSTHSIYMF-FNTSELREAVPEPVLLSRAELRLLRLKL-------KVEQHVELYQKY 174
               S +S + F FN S    ++PE  ++S AELRL R ++       +    + +Y+  
Sbjct: 129 IPGTSENSAFRFLFNLS----SIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVM 184

Query: 175 SNNS--------WRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCD 226
              +         R L  RL+  + +  W +FDV+  V +W        G  +       
Sbjct: 185 KPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQ 243

Query: 227 SRDNTLQ-VDINGFTTGRRGDLATIHGMNRPFLLLMA--------TPLERAQHLQSSRHR 277
           +R +  Q V I+       G+ A +    RP L+           T   RA+       +
Sbjct: 244 TRTHQGQHVRISRSLPQGSGNWAQL----RPLLVTFGHDGRGHALTRRRRAKRSPKHHSQ 299

Query: 278 RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWS---LD 333
           RA   N       KNC    LY+DF  D+GW  WI  P GY A +C G CP+  +     
Sbjct: 300 RARKKN-------KNCRRHSLYVDF-SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNS 351

Query: 334 TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQLSNMIVRSCKC 389
           T ++ V  L N  N     A CCVP  L  + ++Y     K  ++    M+V  C C
Sbjct: 352 TNHAIVQTLVNSVNSSIPKA-CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 95/357 (26%), Positives = 143/357 (40%), Gaps = 57/357 (15%)

Query: 70  PGPLPEAVLALYNSTRDRVAGESAEPEPEP----EADYYAKEVTRVLMVET--HNEIYDK 123
           P P   AV+  Y   RD    +S E E E       +Y  +  +R   V +  H E  + 
Sbjct: 71  PQPSKSAVIPDY--MRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLEN 128

Query: 124 FK-QSTHSIYMF-FNTSELREAVPEPVLLSRAELRLLRLKL-------KVEQHVELYQKY 174
               S +S + F FN S    ++PE  ++S AELRL R ++       +    + +Y+  
Sbjct: 129 IPGTSENSAFRFLFNLS----SIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVM 184

Query: 175 SNNS--------WRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCD 226
              +         R L  RL+  + +  W +FDV+  V +W        G  +       
Sbjct: 185 KPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQ 243

Query: 227 SRDNTLQ-VDINGFTTGRRGDLATIHGMNRPFLLLMA--------TPLERAQHLQSSRHR 277
           +R +  Q V I+       G+ A +    RP L+           T   RA+       +
Sbjct: 244 TRTHQGQHVRISRSLPQGSGNWAQL----RPLLVTFGHDGRGHALTRRRRAKRSPKHHSQ 299

Query: 278 RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWS---LD 333
           RA   N       KNC    LY+DF  D+GW  WI  P GY A +C G CP+  +     
Sbjct: 300 RARKKN-------KNCRRHSLYVDF-SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNS 351

Query: 334 TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQLSNMIVRSCKC 389
           T ++ V  L N  N     A CCVP  L  + ++Y     K  ++    M+V  C C
Sbjct: 352 TNHAIVQTLVNSVNSSIPKA-CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 95/357 (26%), Positives = 143/357 (40%), Gaps = 57/357 (15%)

Query: 70  PGPLPEAVLALYNSTRDRVAGESAEPEPEP----EADYYAKEVTRVLMVET--HNEIYDK 123
           P P   AV+  Y   RD    +S E E E       +Y  +  +R   V +  H E  + 
Sbjct: 71  PQPSKSAVIPDY--MRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLEN 128

Query: 124 FK-QSTHSIYMF-FNTSELREAVPEPVLLSRAELRLLRLKL-------KVEQHVELYQKY 174
               S +S + F FN S    ++PE  ++S AELRL R ++       +    + +Y+  
Sbjct: 129 IPGTSENSAFRFLFNLS----SIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVM 184

Query: 175 SNNS--------WRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCD 226
              +         R L  RL+  + +  W +FDV+  V +W        G  +       
Sbjct: 185 KPPAEVVPGHLITRLLDTRLVHHNVT-RWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQ 243

Query: 227 SRDNTLQ-VDINGFTTGRRGDLATIHGMNRPFLLLMA--------TPLERAQHLQSSRHR 277
           +R +  Q V I+       G+ A +    RP L+           T   RA+       +
Sbjct: 244 TRTHQGQHVRISRSLPQGSGNWAQL----RPLLVTFGHDGRGHALTRRRRAKRSPKHHSQ 299

Query: 278 RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCPYIWS---LD 333
           RA   N       KNC    LY+DF  D+GW  WI  P GY A +C G CP+  +     
Sbjct: 300 RARKKN-------KNCRRHSLYVDF-SDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNS 351

Query: 334 TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQLSNMIVRSCKC 389
           T ++ V  L N  N     A CCVP  L  + ++Y     K  ++    M+V  C C
Sbjct: 352 TNHAIVQTLVNSVNSSIPKA-CCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC 407


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 10/106 (9%)

Query: 293 CCVRQLYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWSLD-------TQYSKVLALYN 344
           C  R+LY+ FR ++GW +W+  P+G+ AN+C G C    +L          ++ + AL +
Sbjct: 267 CRARRLYVSFR-EVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMH 325

Query: 345 QHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
              PGA+  PCCVP  L P+ ++++      V  Q  +M+V  C C
Sbjct: 326 AAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGC 371


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 39/105 (37%), Positives = 58/105 (55%), Gaps = 8/105 (7%)

Query: 291 KNCCVR-QLYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWSL---DTQYSKVLALYNQ 345
           KN C R QL+I+FR DLGW KWI  PKG+ AN+C G CP+  ++    + Y+ + AL + 
Sbjct: 261 KNLCHRHQLFINFR-DLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHA 319

Query: 346 HNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
            +P    A  C+P  L P+ ++Y       +     +M+V  C C
Sbjct: 320 VDPEIPQA-VCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 101/424 (23%), Positives = 166/424 (39%), Gaps = 80/424 (18%)

Query: 16  LWLLVLT--------------PGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLAS 61
           LWLL LT              PG P   L   +  D++    + I A+ G +  + R  +
Sbjct: 8   LWLLGLTLCALGGGGPGLRPPPGCPQRRLGARERRDVQ----REILAVLG-LPGRPRPRA 62

Query: 62  PPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTR--VLMVETHNE 119
           PP+   +P    P  +L LY++    +AG+  E     E      ++    V MVE    
Sbjct: 63  PPAASRLPASA-PLFMLDLYHA----MAGDDDEDGAPAEQRLGRADLVMSFVNMVERDRA 117

Query: 120 IYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLK----LKVEQHVELYQKYS 175
           +     Q  H     F+ ++    +P    ++ AE R+ ++     L    HV ++Q   
Sbjct: 118 LGH---QEPHWKEFRFDLTQ----IPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQ 170

Query: 176 NNSWR-----YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDN 230
             S R     +L  + L   D   WL  DVT     WL +  +  G RL          +
Sbjct: 171 EQSNRESDLFFLDLQTLRAGDEG-WLVLDVTAASDCWLLKRHKDLGLRLYVETE---DGH 226

Query: 231 TLQVDINGFTTGRRGDLATIHGMNRPFLLLM-------------ATPLERAQHLQSSRHR 277
           ++   + G   G+R   +      +PF++                 PL R Q  +S+   
Sbjct: 227 SVDPGLAGLL-GQRAPRS-----QQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELP 280

Query: 278 RALDTNYCFSSTEKN-----CCVRQLYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWS 331
           +A      F     +     C   +LY+ F+ DLGW  W+  P+GY A +C G C +   
Sbjct: 281 QANRLPGIFDDVRGSHGRQVCRRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSF--P 337

Query: 332 LD-----TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVR 385
           LD     T ++ + +L +   P A    CC P  L    ++YY      +  +  NM+V+
Sbjct: 338 LDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVK 397

Query: 386 SCKC 389
           +C C
Sbjct: 398 ACGC 401


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 37/102 (36%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 293 CCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPC--PYIWSLD-TQYSKVLALYNQHNP 348
           C  + L+++F K+LGW  WI  P  Y A  C G C  P    L+ T ++ +  L N  +P
Sbjct: 354 CSKKPLHVNF-KELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDP 412

Query: 349 GASAAPCCVPQALEPLPIVYY-VGRKPKVEQLSNMIVRSCKC 389
           G++   CCVP  L P+ I+Y   G     +Q  +M+V SC C
Sbjct: 413 GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 95/403 (23%), Positives = 160/403 (39%), Gaps = 66/403 (16%)

Query: 23  PGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYN 82
           PG P   L   +  D++    + I A+ G +  + R  +PP+   +P    P  +L LY+
Sbjct: 29  PGCPQRRLGARERRDVQ----REILAVLG-LPGRPRPRAPPAASRLPASA-PLFMLDLYH 82

Query: 83  STRDRVAGESAEPEPEPEADYYAKEVTR--VLMVETHNEIYDKFKQSTHSIYMFFNTSEL 140
           +    +AG+  E     E      ++    V MVE    +     Q  H     F+ ++ 
Sbjct: 83  A----MAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH---QEPHWKEFRFDLTQ- 134

Query: 141 REAVPEPVLLSRAELRLLRLK----LKVEQHVELYQKYSNNSWR-----YLSNRLLAPSD 191
              +P    ++ AE R+ ++     L    HV ++Q     S R     +L  + L   D
Sbjct: 135 ---IPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGD 191

Query: 192 SPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIH 251
              WL  DVT     WL +  +  G RL          +++   + G   G+R   +   
Sbjct: 192 EG-WLVLDVTAASDCWLLKRHKDLGLRLYVETE---DGHSVDPGLAGLL-GQRAPRS--- 243

Query: 252 GMNRPFLLLM-------------ATPLERAQHLQSSRHRRALDTNYCFSSTEKN-----C 293
              +PF++                 PL R Q  +S+   +A      F     +     C
Sbjct: 244 --QQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQVC 301

Query: 294 CVRQLYIDFRKDLGW-KWIHEPKGYHANFCLGPCPYIWSLD-----TQYSKVLALYNQHN 347
              +LY+ F+ DLGW  W+  P+GY A +C G C +   LD     T ++ + +L +   
Sbjct: 302 RRHELYVSFQ-DLGWLDWVIAPQGYSAYYCEGECSF--PLDSCMNATNHAILQSLVHLMM 358

Query: 348 PGASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
           P A    CC P  L    ++YY      +  +  NM+V++C C
Sbjct: 359 PDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 38/102 (37%), Positives = 53/102 (51%), Gaps = 6/102 (5%)

Query: 293 CCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPC--PYIWSLD-TQYSKVLALYNQHNP 348
           C  + L++DF K+LGW  WI  P  Y A  C G C  P    L+ T ++ +  L N   P
Sbjct: 349 CSRKPLHVDF-KELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAP 407

Query: 349 GASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
            A+ A CCVP  L P+ I+Y       V +Q  +M+V +C C
Sbjct: 408 DAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGC 449


>gi|153792495 growth differentiation factor 15 [Homo sapiens]
          Length = 308

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/124 (22%), Positives = 54/124 (43%), Gaps = 2/124 (1%)

Query: 267 RAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGP 325
           R Q  +  R  RA + ++C     + CC         +DLGW  W+  P+      C+G 
Sbjct: 185 RPQAARGRRRARARNGDHCPLGPGR-CCRLHTVRASLEDLGWADWVLSPREVQVTMCIGA 243

Query: 326 CPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVR 385
           CP  +     ++++    ++  P    APCCVP +  P+ ++        ++   +++ +
Sbjct: 244 CPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAK 303

Query: 386 SCKC 389
            C C
Sbjct: 304 DCHC 307


>gi|239757187 PREDICTED: similar to growth differentiation factor 15
           [Homo sapiens]
          Length = 270

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/124 (22%), Positives = 54/124 (43%), Gaps = 2/124 (1%)

Query: 267 RAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGP 325
           R Q  +  R  RA + ++C     + CC         +DLGW  W+  P+      C+G 
Sbjct: 147 RPQAARGRRRARARNGDHCPLGPGR-CCRLHTVRASLEDLGWADWVLSPREVQVTMCIGA 205

Query: 326 CPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVR 385
           CP  +     ++++    ++  P    APCCVP +  P+ ++        ++   +++ +
Sbjct: 206 CPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAK 265

Query: 386 SCKC 389
            C C
Sbjct: 266 DCHC 269


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 43/155 (27%), Positives = 71/155 (45%), Gaps = 22/155 (14%)

Query: 255 RPFLLLMATPLERAQHLQSSR---HRRALDTNYCFSSTEK----------NCCVRQLYID 301
           +P+  L A   E++++ +  R   HR++    +   + +K          NC  R L +D
Sbjct: 319 KPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVD 378

Query: 302 FRKDLGW-KWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHN-----PGASAAPC 355
           F  D+GW +WI  PK + A +C G C +      + S    + +        PG    PC
Sbjct: 379 F-ADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGI-PEPC 436

Query: 356 CVPQALEPLPIVYYVGRKPKVEQL-SNMIVRSCKC 389
           CVP+ +  L I+++   K  V ++  NM V SC C
Sbjct: 437 CVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 35/102 (34%), Positives = 53/102 (51%), Gaps = 6/102 (5%)

Query: 293 CCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPC--PYIWSLD-TQYSKVLALYNQHNP 348
           C  + L+++F KD+GW  WI  P  Y A  C G C  P    L+ T ++ +  L N  +P
Sbjct: 400 CSRKALHVNF-KDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDP 458

Query: 349 GASAAPCCVPQALEPLPIVYYVGRKPKV-EQLSNMIVRSCKC 389
            ++   CCVP  L P+ I++       V +Q  +M+V SC C
Sbjct: 459 ESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 41/141 (29%), Positives = 62/141 (43%), Gaps = 15/141 (10%)

Query: 258 LLLMATPLERAQHLQSS-----RHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGW-KWI 311
           LL  A    RAQ  Q S     RHRR     +      + C   +  +DF   +GW  WI
Sbjct: 212 LLWEAESSWRAQEGQLSWEWGKRHRR-----HHLPDRSQLCRKVKFQVDFNL-IGWGSWI 265

Query: 312 HEPKGYHANFCLGPCPYIWSLD---TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVY 368
             PK Y+A  C G CP     +   T ++ + +L  ++ P    + CC P   +PL ++Y
Sbjct: 266 IYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLY 325

Query: 369 YVGRKPKVEQLSNMIVRSCKC 389
               +  ++   +MIV  C C
Sbjct: 326 VDNGRVLLDHHKDMIVEECGC 346


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 84/392 (21%), Positives = 144/392 (36%), Gaps = 70/392 (17%)

Query: 46  IEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYA 105
           +E ++   L  L L+  PSQ +    P P+ ++ LYN      + +S  P       +  
Sbjct: 59  LENVKVDFLRSLNLSGVPSQDKTRVEP-PQYMIDLYNRY---TSDKSTTPASNIVRSFSM 114

Query: 106 KEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVE 165
           ++   +   E        F    H   + FN S     +P    ++RAELRL    +  +
Sbjct: 115 EDAISITATED-------FPFQKH--ILLFNIS-----IPRHEQITRAELRLY---VSCQ 157

Query: 166 QHVE----------LYQKYSN-NSWRYLSNR--LLAPSDSPE--WLSFDVTGVVRQWLSR 210
            HV+          +Y      ++W   +     L   D  +  W + +V+  V++W+  
Sbjct: 158 NHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRS 217

Query: 211 GGEIEGFRL-----SAHCSCDSRDNTLQ----------VDINGFTTGRRGDLATIHGM-- 253
                  +L     S    CD+ D ++           V  N  ++G +     +  M  
Sbjct: 218 DSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMIS 277

Query: 254 NRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSST----------EKNCCVRQLYIDFR 303
           +    +L     + +     S H    D +    ST            +C    L ++F 
Sbjct: 278 HEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNF- 336

Query: 304 KDLGW-KWIHEPKGYHANFCLGPCPYIWSLD---TQYSKVLALYNQHNPGASAAPCCVPQ 359
           +D+GW  WI  PK Y A  C G C +  + D   T+++ V  L +   P      CCVP 
Sbjct: 337 EDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPT 396

Query: 360 ALEPLPIVYY--VGRKPKVEQLSNMIVRSCKC 389
            L P+ ++Y   +G          M V  C C
Sbjct: 397 KLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,733,345
Number of Sequences: 37866
Number of extensions: 798572
Number of successful extensions: 2577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2477
Number of HSP's gapped (non-prelim): 69
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.