Guide to the Human Genome
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Search of human proteins with 62548862

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
         (937 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]            1954   0.0  
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]            1942   0.0  
gi|11321565 matrilin 3 precursor [Homo sapiens]                       363   e-100
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]             360   4e-99
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]             309   9e-84
gi|56237021 fibrillin 3 precursor [Homo sapiens]                      290   4e-78
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    277   4e-74
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]             276   5e-74
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      276   8e-74
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     273   7e-73
gi|10190748 CEGP1 protein [Homo sapiens]                              255   1e-67
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]               249   6e-66
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]        246   5e-65
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      245   2e-64
gi|46249414 latent transforming growth factor beta binding prote...   238   2e-62
gi|46249412 latent transforming growth factor beta binding prote...   238   2e-62
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]              231   3e-60
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]              219   7e-57
gi|4557733 latent transforming growth factor beta binding protei...   218   3e-56
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]              207   3e-53
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]              207   4e-53
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]              206   8e-53
gi|34734066 fibulin 1 isoform D [Homo sapiens]                        206   8e-53
gi|110347437 latent transforming growth factor beta binding prot...   193   6e-49
gi|110347412 latent transforming growth factor beta binding prot...   193   6e-49
gi|110347431 latent transforming growth factor beta binding prot...   193   6e-49
gi|118572606 hemicentin 1 [Homo sapiens]                              187   3e-47
gi|194328809 latent transforming growth factor beta binding prot...   182   2e-45
gi|18497288 latent transforming growth factor beta binding prote...   176   9e-44
gi|19743803 fibulin 5 precursor [Homo sapiens]                        171   3e-42

>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
          Length = 937

 Score = 1954 bits (5062), Expect = 0.0
 Identities = 937/937 (100%), Positives = 937/937 (100%)

Query: 1   MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
           MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
Sbjct: 1   MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60

Query: 61  IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
           IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
Sbjct: 61  IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120

Query: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
           ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
Sbjct: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180

Query: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
           AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
Sbjct: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240

Query: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
           MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
Sbjct: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
           FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
Sbjct: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
           KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
Sbjct: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420

Query: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
           EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480

Query: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
           TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
Sbjct: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540

Query: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
           VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600

Query: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
           DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
Sbjct: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660

Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
           DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720

Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
           AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780

Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
           KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840

Query: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
           SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
Sbjct: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900

Query: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937
           NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
Sbjct: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937


>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
          Length = 956

 Score = 1942 bits (5032), Expect = 0.0
 Identities = 937/956 (98%), Positives = 937/956 (98%), Gaps = 19/956 (1%)

Query: 1   MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
           MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
Sbjct: 1   MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60

Query: 61  IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
           IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
Sbjct: 61  IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120

Query: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
           ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
Sbjct: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180

Query: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
           AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
Sbjct: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240

Query: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
           MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
Sbjct: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300

Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
           FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
Sbjct: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360

Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
           KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
Sbjct: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420

Query: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
           EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480

Query: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
           TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
Sbjct: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540

Query: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
           VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600

Query: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
           DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
Sbjct: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660

Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
           DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720

Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
           AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780

Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
           KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840

Query: 841 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH 881
           SDGRQDSPAGELPKTVQQPT                   VQHRYLFEEDNLLRSTQKLSH
Sbjct: 841 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH 900

Query: 882 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937
           STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
Sbjct: 901 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 956


>gi|11321565 matrilin 3 precursor [Homo sapiens]
          Length = 486

 Score =  363 bits (932), Expect = e-100
 Identities = 196/417 (47%), Positives = 254/417 (60%), Gaps = 26/417 (6%)

Query: 10  LLILGQIVLLPAEA----------RERSRGRSISRGRH------------ARTHPQTALL 47
           LL+L  ++LLP+ A          R  +RG   S GR               + P  A  
Sbjct: 14  LLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARG 73

Query: 48  ESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKN 107
              C+++  DLVFIIDSSRSV   ++ KVK F+  I+  LDIGP  TRV ++ Y STVK 
Sbjct: 74  AGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKI 133

Query: 108 EFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMI 167
           EF L+ +  K  +++AV R+  LSTGTM+GLAIQ A++ AF+   GAR    N+P+V +I
Sbjct: 134 EFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAII 193

Query: 168 VTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIET 227
           VTDGRPQD V EVAA+A+ +GI ++A+GV + D  +LK + SEP E+HVF V  +  IE 
Sbjct: 194 VTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEK 253

Query: 228 LTSVFQKKLCTAHMCSTLEHNCAHFCINI-PGSYVCRCKQGYILNSDQTTCRIQDLCAME 286
           L+S FQ+  C    C    H C H CI+   G + C C QGY LN+D+ TC   D CA+ 
Sbjct: 254 LSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALN 313

Query: 287 DHNCEQLCVN-VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVN-ADGSYLC 344
            H CE +CVN   GS+ C+CY GY L ED K C A D CA   HGC+H CVN   GS+ C
Sbjct: 314 THGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHC 373

Query: 345 QCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTC 400
           +C+EG+ LN DKKTC+  D CA  +HGCQH CV+    SY C C  G+TLN DKKTC
Sbjct: 374 ECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTC 430



 Score =  172 bits (435), Expect = 2e-42
 Identities = 83/199 (41%), Positives = 114/199 (57%), Gaps = 12/199 (6%)

Query: 356 KKTCTKIDYCASSNHGCQHECVNTDDS-YSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
           ++T   +D C    H CQH C++  +  + C C +G+TLN DKKTC  ++ CALN  GCE
Sbjct: 259 QETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 318

Query: 415 HECVN-MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTE-DSFVCQCSEG 472
           H CVN    SY+C C+ GYTL+ + KTCS  D CA   HGC+ +C+N    S  C+C EG
Sbjct: 319 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 378

Query: 473 FLINEDLKTCSRVDYCLLSDHGCEYSCVNMD-RSFACQCPEGHVLRSDGKTCAKLDSCAL 531
           + +N D KTCS  D C L  HGC++ CV+    S+ C C  G+ L  D KTC+  +    
Sbjct: 379 YTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEA-- 436

Query: 532 GDHGCEHSCVSSEDSFVCQ 550
                    VS+ED+  C+
Sbjct: 437 ------RRLVSTEDACGCE 449



 Score =  171 bits (432), Expect = 4e-42
 Identities = 79/176 (44%), Positives = 106/176 (60%), Gaps = 4/176 (2%)

Query: 480 KTCSRVDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
           +T   +D C+L  H C++ C++  +    C+C +G+ L +D KTC+ LD CAL  HGCEH
Sbjct: 260 ETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEH 319

Query: 539 SCVSSED-SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNS-DDSYTCECLEGF 596
            CV+    S+ C+C+EGY L ED KTC  +D C    HGC+HICVN    S+ CEC EG+
Sbjct: 320 ICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGY 379

Query: 597 RLAEDGKRCRRKDVCKSTHHGCEHICVNNG-NSYICKCSEGFVLAEDGRRCKKCTE 651
            L  D K C  +D C    HGC+HICV++G  SY C C  G+ L ED + C    E
Sbjct: 380 TLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEE 435



 Score =  154 bits (389), Expect = 4e-37
 Identities = 75/187 (40%), Positives = 121/187 (64%)

Query: 649 CTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFT 708
           C   P+DLVF+ID S+S+    F  VK FV+ IID+L I P   RV ++ Y++ V  EF 
Sbjct: 77  CKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQ 136

Query: 709 LRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTD 768
           L+ +   + +K+AV  +  +  G+M+GLA++   + +FT   GAR  S+ +P+ AI+ TD
Sbjct: 137 LQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTD 196

Query: 769 GRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISE 828
           GR QD V+E A++A+A+GI +YAVGV +A    L+ +ASEP  +H+FY E +  ++++S 
Sbjct: 197 GRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSS 256

Query: 829 KLKKGIC 835
           + ++  C
Sbjct: 257 RFQETFC 263


>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
          Length = 581

 Score =  360 bits (923), Expect = 4e-99
 Identities = 180/419 (42%), Positives = 250/419 (59%), Gaps = 48/419 (11%)

Query: 516 LRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
           L+   + CA +D CA G HGCEH CV+S  S+ C C  G++L++D ++CR  D C   +H
Sbjct: 207 LQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNH 265

Query: 576 GCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSE 635
            C+H CV++     C C EG  L  DG+ C+ +D+C    HGCE  CV+ G SY C C E
Sbjct: 266 SCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPE 325

Query: 636 GFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVG 695
           G  L  DG+ C +C EG +DLV ++DGSKS+  +NFE+VK+FV  I+D L +SP+  RVG
Sbjct: 326 GRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVG 385

Query: 696 LLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL 755
           L+Q+S++V TEF L  + +A ++K+AV  ++YM +G+MTGLAL+HM E SF++ +GARP 
Sbjct: 386 LVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPR 445

Query: 756 STRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLF 815
           +  VPR  +VFTDGR+QDD+S WA++AK  GI MYAVGVGKA+E EL+EIASEP   H+ 
Sbjct: 446 ALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVS 505

Query: 816 YAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRS 875
           YA DF TM  + E L+  IC                                 E+ +   
Sbjct: 506 YAPDFGTMTHLLENLRGSIC--------------------------------PEEGISAG 533

Query: 876 TQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRL 934
           T               E    C+CE+L+ FQ      +  LT  L ++T R+E LEN+L
Sbjct: 534 T---------------ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQL 577



 Score =  320 bits (821), Expect = 3e-87
 Identities = 150/319 (47%), Positives = 210/319 (65%)

Query: 43  QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
           Q  L    C     DLVF+IDSSRSV   ++  +++F++ +L+ L++GP+ TRVG++QY 
Sbjct: 20  QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79

Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
           S V++ F L+ F R+ ++ERA++ +  L+ GTMTGLAIQYA+N+AFS AEGARP  E VP
Sbjct: 80  SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139

Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
           RV +IVTDGRPQD VAEVAA+AR  GI I+A+GV + D  +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199

Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
             I+     FQ +LC   +C+   H C H C+N PGSY C C+ G++L  DQ +CR  D 
Sbjct: 200 DLIQEFGLQFQSRLCAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDY 259

Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSY 342
           C+  +H+C+  CV+ PG   C C  G+ L  DG+ C   D C   +HGCE +CV+   SY
Sbjct: 260 CSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSY 319

Query: 343 LCQCHEGFALNPDKKTCTK 361
            C C EG  L  D K+C +
Sbjct: 320 RCLCPEGRQLQADGKSCNR 338



 Score =  169 bits (427), Expect = 1e-41
 Identities = 81/188 (43%), Positives = 126/188 (67%)

Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
           +C  GP+DLVFVID S+S+    FE ++QF+ G++  L + P A RVG++QYS+QV + F
Sbjct: 27  RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86

Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
            LR F+  +DM++A+  +  + +G+MTGLA+++    +F+  EGARP   RVPR A++ T
Sbjct: 87  PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146

Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
           DGR QD V+E A++A+A GI +YAVGV +A    L+ +AS P ++H+F  E F  + E  
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206

Query: 828 EKLKKGIC 835
            + +  +C
Sbjct: 207 LQFQSRLC 214



 Score =  155 bits (393), Expect = 1e-37
 Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)

Query: 51  CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
           C     DLV ++D S+SV   ++  VK F+  I+ FLD+ P+ TRVGL+Q+ S V+ EF 
Sbjct: 339 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 398

Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
           L  +   +EV++AV  + ++  GTMTGLA+++ +  +FSEA+GARP   NVPRV ++ TD
Sbjct: 399 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 458

Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
           GR QD ++  AA+A++ GI+++A+GVG+     L+ I SEP E HV    +F  +  L  
Sbjct: 459 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 518

Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
             +  +C     S    L   C    +           +   LN  Q T R++DL
Sbjct: 519 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 573



 Score =  142 bits (358), Expect = 1e-33
 Identities = 60/127 (47%), Positives = 77/127 (60%)

Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
           R  A+D CA   HGCEH CVN+ GSY C C  GF L  D+++C  IDYC+  NH CQHEC
Sbjct: 212 RLCAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHEC 271

Query: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436
           V+T     CHC +G  L PD ++C+  + C     GCE +CV+   SY C C  G  L  
Sbjct: 272 VSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQA 331

Query: 437 NGKTCSR 443
           +GK+C+R
Sbjct: 332 DGKSCNR 338



 Score =  134 bits (336), Expect = 5e-31
 Identities = 62/148 (41%), Positives = 82/148 (55%), Gaps = 6/148 (4%)

Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
           F L    + C  ID CA   HGC+H CVN+  SY CHC  GF L  D+++CR I+YC+  
Sbjct: 205 FGLQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFG 263

Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
              C+HECV+      C C  G+ L P+G++C   D C   DHGCE  C++   S+ C C
Sbjct: 264 NHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLC 323

Query: 470 SEGFLINEDLKTCSR-----VDYCLLSD 492
            EG  +  D K+C+R     VD  LL D
Sbjct: 324 PEGRQLQADGKSCNRCREGHVDLVLLVD 351



 Score =  128 bits (322), Expect = 2e-29
 Identities = 53/123 (43%), Positives = 74/123 (60%)

Query: 444 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503
           +D CA+  HGCE  C+N+  S+ C C  GF++ +D ++C  +DYC   +H C++ CV+  
Sbjct: 216 IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTP 275

Query: 504 RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT 563
               C C EGH L+ DG++C   D C   DHGCE  CVS   S+ C C EG  L+ DGK+
Sbjct: 276 GGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKS 335

Query: 564 CRR 566
           C R
Sbjct: 336 CNR 338



 Score =  120 bits (300), Expect = 8e-27
 Identities = 52/136 (38%), Positives = 77/136 (56%), Gaps = 1/136 (0%)

Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
           ++ F L    + C  I+ CA    GCEH CVN   SY+C C  G+ L  + ++C  +D+C
Sbjct: 202 IQEFGLQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYC 260

Query: 448 AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
           +  +H C+  C++T     C C EG  +  D ++C   D C   DHGCE+ CV+   S+ 
Sbjct: 261 SFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYR 320

Query: 508 CQCPEGHVLRSDGKTC 523
           C CPEG  L++DGK+C
Sbjct: 321 CLCPEGRQLQADGKSC 336


>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
          Length = 540

 Score =  309 bits (791), Expect = 9e-84
 Identities = 157/367 (42%), Positives = 216/367 (58%), Gaps = 47/367 (12%)

Query: 568 DVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGN 627
           D C   +H C+H CV++     C C EG  L  DG+ C+ +D+C    HGCE  CV+ G 
Sbjct: 217 DYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGL 276

Query: 628 SYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTI 687
           SY C C EG  L  DG+ C +C EG +DLV ++DGSKS+  +NFE+VK+FV  I+D L +
Sbjct: 277 SYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDV 336

Query: 688 SPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFT 747
           SP+  RVGL+Q+S++V TEF L  + +A ++K+AV  ++YM +G+MTGLAL+HM E SF+
Sbjct: 337 SPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFS 396

Query: 748 QGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIAS 807
           + +GARP +  VPR  +VFTDGR+QDD+S WA++AK  GI MYAVGVGKA+E EL+EIAS
Sbjct: 397 EAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIAS 456

Query: 808 EPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLF 867
           EP   H+ YA DF TM  + E L+  IC                                
Sbjct: 457 EPAELHVSYAPDFGTMTHLLENLRGSIC-------------------------------- 484

Query: 868 EEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRM 927
            E+ +   T               E    C+CE+L+ FQ      +  LT  L ++T R+
Sbjct: 485 PEEGISAGT---------------ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARL 529

Query: 928 EALENRL 934
           E LEN+L
Sbjct: 530 EDLENQL 536



 Score =  269 bits (688), Expect = 8e-72
 Identities = 131/276 (47%), Positives = 184/276 (66%)

Query: 43  QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
           Q  L    C     DLVF+IDSSRSV   ++  +++F++ +L+ L++GP+ TRVG++QY 
Sbjct: 20  QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79

Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
           S V++ F L+ F R+ ++ERA++ +  L+ GTMTGLAIQYA+N+AFS AEGARP  E VP
Sbjct: 80  SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139

Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
           RV +IVTDGRPQD VAEVAA+AR  GI I+A+GV + D  +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199

Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
             I+     FQ +LC    CS   H+C H C++ PG   C C++G+ L  D  +C+++DL
Sbjct: 200 DLIQEFGLQFQSRLCAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDL 259

Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
           C   DH CE  CV+   S+ C C  G  L  DGK C
Sbjct: 260 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 295



 Score =  169 bits (427), Expect = 1e-41
 Identities = 81/188 (43%), Positives = 126/188 (67%)

Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
           +C  GP+DLVFVID S+S+    FE ++QF+ G++  L + P A RVG++QYS+QV + F
Sbjct: 27  RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86

Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
            LR F+  +DM++A+  +  + +G+MTGLA+++    +F+  EGARP   RVPR A++ T
Sbjct: 87  PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146

Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
           DGR QD V+E A++A+A GI +YAVGV +A    L+ +AS P ++H+F  E F  + E  
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206

Query: 828 EKLKKGIC 835
            + +  +C
Sbjct: 207 LQFQSRLC 214



 Score =  155 bits (393), Expect = 1e-37
 Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)

Query: 51  CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
           C     DLV ++D S+SV   ++  VK F+  I+ FLD+ P+ TRVGL+Q+ S V+ EF 
Sbjct: 298 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 357

Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
           L  +   +EV++AV  + ++  GTMTGLA+++ +  +FSEA+GARP   NVPRV ++ TD
Sbjct: 358 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 417

Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
           GR QD ++  AA+A++ GI+++A+GVG+     L+ I SEP E HV    +F  +  L  
Sbjct: 418 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 477

Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
             +  +C     S    L   C    +           +   LN  Q T R++DL
Sbjct: 478 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 532



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 38/86 (44%), Positives = 50/86 (58%)

Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
           R  A+DYC+  NH C+HECV+  G   C C EG  L PD ++C   D C   +HGC+ +C
Sbjct: 212 RLCAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQC 271

Query: 377 VNTDDSYSCHCLKGFTLNPDKKTCRR 402
           V+   SY C C +G  L  D K+C R
Sbjct: 272 VSEGLSYRCLCPEGRQLQADGKSCNR 297



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 40/94 (42%), Positives = 53/94 (56%), Gaps = 1/94 (1%)

Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
           F L    + C  IDYC+  NH CQHECV+T     CHC +G  L PD ++C+  + C   
Sbjct: 205 FGLQFQSRLCA-IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGV 263

Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR 443
             GCE +CV+   SY C C  G  L  +GK+C+R
Sbjct: 264 DHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 297



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 37/82 (45%), Positives = 48/82 (58%)

Query: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
           +DYC   +H C++ CV+      C C EGH L+ DG++C   D C   DHGCE  CVS  
Sbjct: 216 IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEG 275

Query: 545 DSFVCQCFEGYILREDGKTCRR 566
            S+ C C EG  L+ DGK+C R
Sbjct: 276 LSYRCLCPEGRQLQADGKSCNR 297



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 32/80 (40%), Positives = 48/80 (60%)

Query: 444 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503
           +D+C+  +H C+  C++T     C C EG  +  D ++C   D C   DHGCE+ CV+  
Sbjct: 216 IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEG 275

Query: 504 RSFACQCPEGHVLRSDGKTC 523
            S+ C CPEG  L++DGK+C
Sbjct: 276 LSYRCLCPEGRQLQADGKSC 295



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 40/110 (36%), Positives = 57/110 (51%), Gaps = 6/110 (5%)

Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
           ++ F L    + C  I+YC+     C+HECV+      C C  G+ L P+G++C   D C
Sbjct: 202 IQEFGLQFQSRLCA-IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLC 260

Query: 448 AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-----VDYCLLSD 492
              DHGCE  C++   S+ C C EG  +  D K+C+R     VD  LL D
Sbjct: 261 NGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVD 310


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score =  290 bits (742), Expect = 4e-78
 Identities = 158/429 (36%), Positives = 215/429 (50%), Gaps = 25/429 (5%)

Query: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
            C      C H  C N  GS+ C C  G+ L++ +  C   D C +    C Q  CVN PG
Sbjct: 990  CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPG 1049

Query: 300  SFVCQCYSGYALAEDG----KRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNP 354
            SF C+C+ GY   E G    K C+ VD CA +   C    C N DGSY CQC  G  L  
Sbjct: 1050 SFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTA 1106

Query: 355  DKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
                C  ID C+ S+  C H +CVN   ++ C C  GF   PD++ C  IN C +   GC
Sbjct: 1107 KGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC 1166

Query: 414  EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEG 472
            +  C+N E SY C C +GY+L P+G+ C+ VD C +    C+Q  C N      C C +G
Sbjct: 1167 DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDG 1226

Query: 473  FLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL 531
            F+   D++TC  VD C L+ H C +  C N   SF C C  G+++R     C+ +D C +
Sbjct: 1227 FMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEV 1286

Query: 532  GDHGCEH--SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDS 587
            G H C+   SC++   SF C+C  G++   DG  C   D C + +H C     C+N   S
Sbjct: 1287 GGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGS 1344

Query: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646
            Y C C +GF  A DG  C  +D C      C++  C+N    Y C+C  GF   ED R C
Sbjct: 1345 YRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402

Query: 647  K---KCTEG 652
            +   +C +G
Sbjct: 1403 QDVDECAQG 1411



 Score =  216 bits (551), Expect = 6e-56
 Identities = 136/447 (30%), Positives = 184/447 (41%), Gaps = 40/447 (8%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVP 298
            CS     CA  C N  GSY+C C  GY L  D   CR  D CA    +C      C N+ 
Sbjct: 2170 CSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229

Query: 299  GSFVCQCYSGYA-LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDK 356
            G+F C C  G   L   G+ C   + C ++   C +  CVN  GS+ C C EGF  +P  
Sbjct: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289

Query: 357  KTCTKIDYCASSNHGCQHECVNTDDSYS------CHCLKGFTLNPDKKTC---------- 400
              C  I          Q  C +   S        C C  G    P  + C          
Sbjct: 2290 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRK 2349

Query: 401  ------------RRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
                        R ++ C +    C H EC+N   S+ C C  GYT D    TC  +D C
Sbjct: 2350 LCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409

Query: 448  AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
            +Q    C  LC NT+ SF+C C  G+L+ ED +TC  +D C    H C++ CVN   +F 
Sbjct: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469

Query: 508  CQCPEGHVLRSDGKTCAKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
            C+CP G       + C   D C+   G  G    C ++  SF C+C +G+ L   G  C 
Sbjct: 2470 CRCPPG--FTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527

Query: 566  RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVN 624
              + C    H C+H C N    Y C C +GF       +C  ++ C  +   C    C N
Sbjct: 2528 DVNECDG-PHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586

Query: 625  NGNSYICKCSEGFVLAEDGRRCKKCTE 651
                + C C  GF   +    C++  E
Sbjct: 2587 TLGGFRCVCPSGFDFDQALGGCQEVDE 2613



 Score =  205 bits (521), Expect = 2e-52
 Identities = 131/421 (31%), Positives = 189/421 (44%), Gaps = 33/421 (7%)

Query: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVP 298
            C    H C H  C N  GS+VC C+ GY++    T C   D C +  HNC+    C+N+P
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301

Query: 299  GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDK 356
            GSF C+C  G+    DG  C  +D C S+ H C    +C+N  GSY C C +GFA   D 
Sbjct: 1302 GSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDG 1357

Query: 357  KTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH 415
              C   D CA +   C + +C+N    Y C C  GF    D + C+ ++ CA        
Sbjct: 1358 FFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG 1417

Query: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
             C N+   + C C+ GY LD  G  C+ ++ CA   +    +C+NT  S++C C + F +
Sbjct: 1418 SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477

Query: 476  NEDLKTC--SRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG- 532
            N     C  +R   C L  H         D   +C    G      G T A    C+LG 
Sbjct: 1478 NPSGVGCVDTRAGNCFLETHD------RGDSGISCSAEIG-----VGVTRASC-CCSLGR 1525

Query: 533  --DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCE-HICVNSDDS 587
               + CE   +++   +   C  G   + +  T   +D+  CQ +   C+   CVN+  S
Sbjct: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS 1585

Query: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAEDGRR 645
            + CEC  G+ L+E  + C   D C STH G      C N   +Y C C   ++    G  
Sbjct: 1586 FQCECPPGYHLSEHTRICEDIDEC-STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644

Query: 646  C 646
            C
Sbjct: 1645 C 1645



 Score =  201 bits (511), Expect = 3e-51
 Identities = 132/454 (29%), Positives = 184/454 (40%), Gaps = 48/454 (10%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGS 300
            C      C   CIN  GSY C C QGY L  D   C   D C      C+Q  C N+PG 
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG 1218

Query: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
              C CY G+    D + CV VD C    H C H +C N  GS++C C  G+ +      C
Sbjct: 1219 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC 1278

Query: 360  TKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-- 415
            + +D C    H C     C+N   S+SC CL G+    D   C  ++ C   +  C    
Sbjct: 1279 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRG 1336

Query: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474
            +C+N+  SY C C +G+  D  G  C   D CA+    C+   CLN    + C+C  GF 
Sbjct: 1337 DCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFD 1394

Query: 475  INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
              ED + C  VD C   +     SC N+   F C C  G+ L   G  C  ++ CA   +
Sbjct: 1395 PTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN 1454

Query: 535  GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564
                 C+++  S++C C + + L   G  C                              
Sbjct: 1455 CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGV 1514

Query: 565  RRKDVC----QAIDHGCEHICVNSDDSYTCECL--EGFRLAEDGKRCRRKDVCKSTHHGC 618
             R   C    +A  + CE   + +   Y   C   EGF+           D C+     C
Sbjct: 1515 TRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC 1574

Query: 619  EH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
            +   CVN   S+ C+C  G+ L+E  R C+   E
Sbjct: 1575 QGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE 1608



 Score =  198 bits (503), Expect = 2e-50
 Identities = 130/408 (31%), Positives = 173/408 (42%), Gaps = 43/408 (10%)

Query: 281 DLCAMEDHNC-EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNA 338
           D+C    + C    C+  P S+ C+C  GY     G+ C+ VD C S    C H +CVN 
Sbjct: 410 DICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSP--CHHGDCVNI 466

Query: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQ-HECVNTDDSYSCHCLKGFTLNPDK 397
            G+Y C+C+ GF   P ++ C  +D C  S   C    CVNT+ S+ C C  GF L+PD 
Sbjct: 467 PGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDG 526

Query: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457
           K C   N CA +       C+N + S+ C C  G+ L P G  C  +D C          
Sbjct: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586

Query: 458 CLNTEDSFVCQCSEGFLINEDLKTC-----SRVDYCLLSDHGC-----------EYSCVN 501
           C NTE SF CQC  G  +  D + C         Y  +    C           E  C N
Sbjct: 587 CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646

Query: 502 MDRSFA--CQ-------------CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSED 545
            D  F   CQ             C  G  + +DG+    ++ CAL    C +  C +   
Sbjct: 647 PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRG 703

Query: 546 SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKR 604
           S+ C C  GY     GK C   D C      C++  C NS  SY+C C  GF   +D + 
Sbjct: 704 SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763

Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
           C+  D C S+      +C N   SY CKC  G  L   G  C   T+G
Sbjct: 764 CKDVDECLSS-PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKG 810



 Score =  197 bits (500), Expect = 5e-50
 Identities = 110/314 (35%), Positives = 142/314 (45%), Gaps = 8/314 (2%)

Query: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
            C  L H CAH  CIN  GS+ C C+ GY  ++  TTC   D C+     C  LC N  GS
Sbjct: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGS 2426

Query: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
            F+C C  GY L EDG+ C  +D C S  H C+  CVN  G++ C+C  GF  +   + C 
Sbjct: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH--HQACF 2484

Query: 361  KIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
              D C++    C     C NT  S+ C C +GFTL      C  +N C      C+H C 
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQ 2543

Query: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL-CLNTEDSFVCQCSEGFLINE 477
            N    Y C C +G+T       C   + CA     C    C NT   F C C  GF  ++
Sbjct: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQ 2603

Query: 478  DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-SCALGDHGC 536
             L  C  VD C      C YSC N    F C CP+G+     G   + L  S    D   
Sbjct: 2604 ALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPD 2663

Query: 537  EHSCVSSEDSFVCQ 550
            +   +SSE  + C+
Sbjct: 2664 KEELLSSEACYECK 2677



 Score =  191 bits (485), Expect = 3e-48
 Identities = 148/515 (28%), Positives = 201/515 (39%), Gaps = 95/515 (18%)

Query: 228  LTSVFQKKLCTAHMCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME 286
            LT +   K      C  +   CA+  CIN  GS+ C C  G+  NS    C   D C   
Sbjct: 1711 LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770

Query: 287  DHNCEQL--CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYL 343
            +  C+Q   C+N+PGS+ C+C  GY L+  G  CV  + C    + C H +C++ +GSY+
Sbjct: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYM 1829

Query: 344  CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI 403
            C CH GF  + D+  C  ID C     G    C N   SY+C C  GF +      C   
Sbjct: 1830 CLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT-HNGDCVDF 1887

Query: 404  NYC-ALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLN 460
            + C  L    C    C+N   S++C C  G+ L  +GK C   + C      C    C N
Sbjct: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQN 1947

Query: 461  TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSD 519
             E SF C C  GF +  D   C  +D C    + C + +C N   SF C CP G VL  +
Sbjct: 1948 LEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDN 2005

Query: 520  GKTC-------------------------AKLDSCALGDHG------CEHSCVSSEDSF- 547
            G  C                          K   C     G      CE        +F 
Sbjct: 2006 GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQ 2065

Query: 548  -VCQCFEGYILREDGKTCRRKDVCQAIDHG--CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
             +C    G +    G    R+DV +  ++   C + +CVN+D S+ CEC  G+ L   G 
Sbjct: 2066 ELCPFGHGAV---PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGI 2122

Query: 604  RCRRKDVCKSTH---------------------------HGCEHI-------------CV 623
             C   D C   H                             CE I             C 
Sbjct: 2123 NCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCH 2182

Query: 624  NNGNSYICKCSEGFVLAEDGRRCK---KCTEGPID 655
            N   SY+C C  G+ L EDG  C+   +C +G  D
Sbjct: 2183 NTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217



 Score =  189 bits (481), Expect = 8e-48
 Identities = 137/455 (30%), Positives = 188/455 (41%), Gaps = 63/455 (13%)

Query: 249 CAHF--------CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
           C HF        C+  P SY C C  GY  +       + +  +   H+ +  CVN+PG+
Sbjct: 412 CRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD--CVNIPGT 469

Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTC 359
           + C+CY G+      + CV VD C      C    CVN +GS+ C C+ GF L+PD K C
Sbjct: 470 YHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529

Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
              + CA+S       C+N D S+SC C  GF L P    C  I+ C          C N
Sbjct: 530 VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTN 589

Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDH-----------------------------CAQQ 450
            E S+ C+C  G  +  +G+ C  VD                              CA  
Sbjct: 590 TEGSFRCQCLGGLAVGTDGRVC--VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANP 647

Query: 451 DHG----CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRS 505
           DHG    C+         F   CS G  I  D +    ++ C L    C    C N+  S
Sbjct: 648 DHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD---INECALDPEVCANGVCENLRGS 704

Query: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC 564
           + C C  G+   + GK C  +D CAL    C++  C +S  S+ C C  G+   +D + C
Sbjct: 705 YRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEIC 764

Query: 565 RRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC--KSTHHGCE 619
             KDV + +   C   +C N   SYTC+C  G RL   G  C    K  C  K     CE
Sbjct: 765 --KDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822

Query: 620 HICVN-NGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
              VN  G S   +C    + A  G  C++C   P
Sbjct: 823 ---VNLQGASLRSECC-ATLGAAWGSPCERCEIDP 853



 Score =  184 bits (467), Expect = 3e-46
 Identities = 118/402 (29%), Positives = 168/402 (41%), Gaps = 47/402 (11%)

Query: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHEC-VNADGSY---LCQCHEG 349
            CVN  GSF C+C  G  L   G+ CV V          E EC V   G Y   +C C  G
Sbjct: 885  CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG 944

Query: 350  FALNPDKKTC---TKIDYCASSNHG---------------------------CQH-ECVN 378
                 + + C     +++ +    G                           C H  C N
Sbjct: 945  AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRN 1004

Query: 379  TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPN 437
            T  S+ C C  GF L+  ++ C  I+ C ++   C +  CVN   S+ C C  GY    +
Sbjct: 1005 TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGY---ES 1061

Query: 438  G----KTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD 492
            G    K C  VD CA+    C    C NT+ S+ CQC  G  +      C  +D C LSD
Sbjct: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSD 1121

Query: 493  HGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
              C +  CVN+  +F C C  G     D + C  ++ C + + GC+  C+++E S+ C C
Sbjct: 1122 GLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSC 1181

Query: 552  FEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDV 610
             +GY L  DG+ C   D C+     C+   C N    + C C +GF    D + C   D 
Sbjct: 1182 GQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241

Query: 611  CKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
            C    H C H  C N   S++C C  G+++ +    C    E
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283



 Score =  180 bits (457), Expect = 5e-45
 Identities = 139/497 (27%), Positives = 196/497 (39%), Gaps = 91/497 (18%)

Query: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMED------------- 287
            C  + + C+H  C++  GSY+C C +G+  ++DQT C   D C  +              
Sbjct: 1809 CREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSY 1868

Query: 288  -----------HN--------CEQL---------CVNVPGSFVCQCYSGYALAEDGKRCV 319
                       HN        C  L         C+N  GSF C C  G+ L  DGK CV
Sbjct: 1869 NCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV 1928

Query: 320  AVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECV 377
              + C S    C    C N +GS+ C C  GF +  D   C  ID C+   + C    C 
Sbjct: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986

Query: 378  NTDDSYSCHCLKGFTLNPDKKTC-------------------------RRINYCALNKPG 412
            N+  S+ C C  GF L+ +   C                          +   C   +PG
Sbjct: 1987 NSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPG 2046

Query: 413  ------CEHECVNMEESYYCRCHRGYTLDPNGKTCSR--VDHCAQQDHGCEQ-LCLNTED 463
                  CE        ++   C  G+   P G   SR  V+ CA+    C   +C+NT+ 
Sbjct: 2047 EGWGDPCELCPQEGSAAFQELCPFGHGAVP-GPDDSREDVNECAENPGVCTNGVCVNTDG 2105

Query: 464  SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDG--K 521
            SF C+C  G+ ++     C   D C +     + +C N+   F C C +G      G   
Sbjct: 2106 SFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGF---EPGLMM 2162

Query: 522  TCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI- 580
            TC  +D C+L    C   C ++E S++C C  GY LREDG  CR  D C      C    
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222

Query: 581  --CVNSDDSYTCECLEGFR-LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEG 636
              C N   ++ C C  G R L   G+ C   + C +    C +  CVN   S+ C C EG
Sbjct: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEG 2282

Query: 637  FVLAEDGRRCKKCTEGP 653
            F  +     C    +GP
Sbjct: 2283 FQPSPTLTECHDIRQGP 2299



 Score =  167 bits (424), Expect = 3e-41
 Identities = 133/475 (28%), Positives = 189/475 (39%), Gaps = 82/475 (17%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
            +C N PGSY C C  G+    D   C+  D C +       +C N+ GS+ C+C  G  L
Sbjct: 739  WCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRL 797

Query: 312  AEDGKRCV----AVDYCASENHGCEHECVNADGSYL---------------CQ------- 345
               G  C+       +   +   CE   VN  G+ L               C+       
Sbjct: 798  DPSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECCATLGAAWGSPCERCEIDPA 854

Query: 346  CHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRI- 403
            C  GFA      TC  ++ C S    C +  CVNT  S+ C C +G  L+   + C  + 
Sbjct: 855  CARGFA-RMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913

Query: 404  ----------NYCALNKPG------------------CEHECVNMEE-SYYCRCHRGYTL 434
                      + C +  PG                  CE  C + E   +   C RG   
Sbjct: 914  LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-ACPDPESLEFASLCPRGLGF 972

Query: 435  DPNGKTCSR-----VDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC 488
                    R     V+ C      C    C NT  SF C C+ GF ++   + C+ +D C
Sbjct: 973  ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1032

Query: 489  LLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDG----KTCAKLDSCALGDHGCE-HSCVS 542
             +S   C + +CVN   SF C+C  G+     G    K C  +D CA     C   +C +
Sbjct: 1033 RISPDLCGQGTCVNTPGSFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTN 1089

Query: 543  SEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAED 601
            ++ S+ CQC  G+ L   G  C   D C   D  C H  CVN   ++ C C  GF+   D
Sbjct: 1090 TDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPD 1149

Query: 602  GKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC---KKCTEGP 653
             + C   + C+  + GC+  C+N   SY C C +G+ L  DGR C    +C E P
Sbjct: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204



 Score =  157 bits (398), Expect = 3e-38
 Identities = 120/406 (29%), Positives = 171/406 (42%), Gaps = 47/406 (11%)

Query: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHN--CE-QLCVN 296
            CST    C    C N  G+Y C C   Y+ +N       ++       +N  C+ +L  N
Sbjct: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN 1668

Query: 297  VPGSFVCQCYS-GYALAEDGKRC---VAVDY---CASENHG------------------- 330
            V     C  Y+ G A     + C   ++ DY   C ++  G                   
Sbjct: 1669 VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI 1728

Query: 331  ---CEHE-CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH--ECVNTDDSYS 384
               C +  C+N  GS+ C+C  GF  N     C  +D C S    CQ   +C+N   SY 
Sbjct: 1729 PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYR 1788

Query: 385  CHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR 443
            C C +G+ L+P    C   N C      C H +C++ E SY C CHRG+    +   C  
Sbjct: 1789 CKCTRGYKLSPG-GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847

Query: 444  VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYS-CVN 501
            +D C +Q  G    C N   S+ C C  GF++  +   C   D C  L    C +  C+N
Sbjct: 1848 IDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGHCLN 1905

Query: 502  MDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560
               SF C C +G  L +DGK C   + C +L       +C + E SF C C  G+ ++ D
Sbjct: 1906 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD 1965

Query: 561  GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
               C   D C    + C    C NS  S+ C C  GF L+++G RC
Sbjct: 1966 --HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009



 Score =  150 bits (379), Expect = 5e-36
 Identities = 146/556 (26%), Positives = 205/556 (36%), Gaps = 138/556 (24%)

Query: 235  KLCTAHM-CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293
            K C  H  C+T        C+N  GS+ C CK G++L      C   D C          
Sbjct: 527  KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586

Query: 294  CVNVPGSFVCQCYSGYALAEDGKRCV----------AVD-----------------YCAS 326
            C N  GSF CQC  G A+  DG+ CV          A++                  CA+
Sbjct: 587  CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646

Query: 327  ENHG----CE---------------------------HECV------------NADGSYL 343
             +HG    C+                           +EC             N  GSY 
Sbjct: 647  PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYR 706

Query: 344  CQCHEGFALNPDKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRR 402
            C C+ G+      K CT +D CA ++  C +  C N+  SYSC C  GF    D + C+ 
Sbjct: 707  CVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKD 766

Query: 403  INYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC--SRVDHC--AQQDHGCE--- 455
            ++ C L+ P     C N+  SY C+C  G  LDP+G  C  S    C    Q+  CE   
Sbjct: 767  VDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNL 825

Query: 456  -------QLC--LNTEDSFVCQ-------CSEGFLINEDLKTCSRVDYCLLSDHGCEYS- 498
                   + C  L       C+       C+ GF     + TC  V+ C      C    
Sbjct: 826  QGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV-TCDDVNECESFPGVCPNGR 884

Query: 499  CVNMDRSFACQCPEGHVLRSDGKTC--AKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEG 554
            CVN   SF C+CPEG +L + G+ C   +L+ C L   +  C  +        VC C  G
Sbjct: 885  CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG 944

Query: 555  YILREDGKTCR----------------------------RKDV--CQAIDHGCEH-ICVN 583
             +   + + C                              KDV  C+     C H  C N
Sbjct: 945  AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRN 1004

Query: 584  SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC----SEGFV 638
            +  S+ C C  GF L    + C   D C+ +   C +  CVN   S+ C+C      GF+
Sbjct: 1005 TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFM 1064

Query: 639  LAEDGRRCKKCTEGPI 654
            L ++     +C   P+
Sbjct: 1065 LMKNCMDVDECARDPL 1080



 Score =  150 bits (378), Expect = 7e-36
 Identities = 115/436 (26%), Positives = 163/436 (37%), Gaps = 57/436 (13%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C+N PG Y C C+ G+    D   C+  D CA  +      C N+PG F C C  GY L 
Sbjct: 1378 CLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELD 1437

Query: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYCASSNH 370
              G  C  ++ CA   +     C+N  GSYLC C + F LNP    C  T+   C    H
Sbjct: 1438 RGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETH 1497

Query: 371  GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP---GCEHECVNMEESYYCR 427
                     D   SC    G  +   + +C     C+L +     CE   +     Y   
Sbjct: 1498 D------RGDSGISCSAEIG--VGVTRASC----CCSLGRAWGNPCELCPMANTTEYRTL 1545

Query: 428  CHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
            C  G    PN  T     +D C +    C+   C+NT  SF C+C  G+ ++E  + C  
Sbjct: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605

Query: 485  VDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH---GCEHSC 540
            +D C      C   +C N   ++ C CP  ++  + G  C  +       H    C++  
Sbjct: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL 1665

Query: 541  VSSEDSFVCQCFE--GYILREDGKTCRRK----------------------------DVC 570
              +    +C C    G       + C                               D C
Sbjct: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725

Query: 571  QAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICVNNGN 627
              I   C + IC+N   S+ CEC  GF        C   D C S    C+    C+N   
Sbjct: 1726 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785

Query: 628  SYICKCSEGFVLAEDG 643
            SY CKC+ G+ L+  G
Sbjct: 1786 SYRCKCTRGYKLSPGG 1801



 Score =  137 bits (344), Expect = 6e-32
 Identities = 123/470 (26%), Positives = 170/470 (36%), Gaps = 91/470 (19%)

Query: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
           C++G+I N     C+  D C      C+   CVN+ GSF C+C  G+ L++    C   D
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC--ED 289

Query: 323 Y----CASENHG--CEHECVNADGSYLCQCHEG--FALNPDKKTCTKIDYCASSNHGCQH 374
           Y    C S   G  C  +         C C  G  +A  P  + C         ++  Q 
Sbjct: 290 YRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP-----PRGSNEFQQ 344

Query: 375 ECVNTDDSYSCH-----CLKGF------------TLNPDKKTCR----------RINYCA 407
            C         H      L GF             LNP     R           I    
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404

Query: 408 LNK--PGCEH--------ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGCE 455
           LN+    C H         C+    SY C C+ GYT D  G+ C  VD C      HG  
Sbjct: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGD- 462

Query: 456 QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGH 514
             C+N   ++ C+C  GF      + C  VD C++S   C    CVN + SF C C  G 
Sbjct: 463 --CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF 520

Query: 515 VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAID 574
            L  DGK C   + CA         C++ + SF C C  G++L   G  C   D CQ   
Sbjct: 521 ELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG 580

Query: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRC---------------------------RR 607
                 C N++ S+ C+CL G  +  DG+ C                           + 
Sbjct: 581 ICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640

Query: 608 KDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
           +  C +  HG    C+     +   +   CS G  +  DGR   +C   P
Sbjct: 641 ECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDP 690



 Score =  136 bits (343), Expect = 8e-32
 Identities = 91/336 (27%), Positives = 135/336 (40%), Gaps = 41/336 (12%)

Query: 362 IDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVN 419
           ID C    + C +  C+ T  SY C C  G+T +  +  C  ++ C  +   C H +CVN
Sbjct: 409 IDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDV-RGECIDVDECTSSP--CHHGDCVN 465

Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINED 478
           +  +Y+CRC+ G+   P  + C  VD C      C    C+NTE SF C C+ GF ++ D
Sbjct: 466 IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525

Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
            K C   + C  S       C+N D SF+C C  G +L   G  C  +D C         
Sbjct: 526 GKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNG 585

Query: 539 SCVSSEDSFVCQCFEGYILREDGKTC---------------------------RRKDVCQ 571
            C ++E SF CQC  G  +  DG+ C                           + +  C 
Sbjct: 586 HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCA 645

Query: 572 AIDHG----CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNG 626
             DHG    C+         +   C  G  +  DG+       C      C + +C N  
Sbjct: 646 NPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINE---CALDPEVCANGVCENLR 702

Query: 627 NSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDG 662
            SY C C+ G+     G+ C    E  ++ +   +G
Sbjct: 703 GSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG 738



 Score =  113 bits (283), Expect = 7e-25
 Identities = 105/409 (25%), Positives = 154/409 (37%), Gaps = 63/409 (15%)

Query: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
           +LC  + H C +        F+   ++G         C  VD C +    C+   CVN  
Sbjct: 223 ELCPAQPHPCRR-------GFIPNIHTG--------ACQDVDECQAVPGLCQGGSCVNMV 267

Query: 340 GSYLCQCHEGFALNPDKKTCT--KIDYCASSNHG--CQHECVNTDDSYSCHCLKG--FTL 393
           GS+ C+C  G  L+     C   +   C S   G  C  +         C C +G  +  
Sbjct: 268 GSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAA 327

Query: 394 NPDKKTC--RRIN----YCAL------NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
            P  + C  R  N     CA         PG     +    +          L+P+G   
Sbjct: 328 GPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDA 387

Query: 442 -------------------SRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLINEDLK- 480
                                +D C    + C    CL T  S+ C+C+ G+   +D++ 
Sbjct: 388 RGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY--TQDVRG 445

Query: 481 TCSRVDYCLLS--DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE- 537
            C  VD C  S   HG    CVN+  ++ C+C  G       + C  +D C +    C  
Sbjct: 446 ECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL 502

Query: 538 HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597
             CV++E SF C C  G+ L  DGK C   + C         +C+N D S++C C  GF 
Sbjct: 503 GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL 562

Query: 598 LAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
           LA  G  C   D C++        C N   S+ C+C  G  +  DGR C
Sbjct: 563 LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 61/211 (28%), Positives = 74/211 (35%), Gaps = 46/211 (21%)

Query: 346 CHEGFALNPDKKTC---TKIDYCA-SSNHGCQHECVN--TDDSYSCHCLKGFTLNPDKKT 399
           C EGF   P+  TC   T    C  S   GC   C+N  T    SC C KG+T       
Sbjct: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT----- 144

Query: 400 CRRINYCALNKPGCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGC 454
                     +P C+  C N         C C  G+ + P  +   R   C  Q    GC
Sbjct: 145 -------VCGQPICDRGCHNGGRCIGPNRCACVYGF-MGPQCERDYRTGPCFGQVGPEGC 196

Query: 455 EQ----------LCLNTED---SFVCQ--------CSEGFLINEDLKTCSRVDYCLLSDH 493
           +           LC  T        C+        C  GF+ N     C  VD C     
Sbjct: 197 QHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG 256

Query: 494 GCEY-SCVNMDRSFACQCPEGHVLRSDGKTC 523
            C+  SCVNM  SF C+CP GH L      C
Sbjct: 257 LCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 66/265 (24%), Positives = 92/265 (34%), Gaps = 47/265 (17%)

Query: 387 CLKGFTLNPDKKTCRRINY---CALNK-PGCEHECVNME--ESYYCRCHRGYTLDPNGKT 440
           C +GF   P+  TC        C +++  GC   C+N        C C +GYT    G  
Sbjct: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145

Query: 441 CSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL--LSDHGCE 496
           C +   C   D GC     C+       C C  GF+     +   R   C   +   GC+
Sbjct: 146 CGQ-PIC---DRGCHNGGRCIGPNR---CACVYGFM-GPQCERDYRTGPCFGQVGPEGCQ 197

Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556
           +    +  + A  C    V R+ G  C   + C    H C                 G+I
Sbjct: 198 HQLTGLVCTKALCCAT--VGRAWGLPC---ELCPAQPHPCRR---------------GFI 237

Query: 557 LREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR--RKDVCKS 613
                  C+  D CQA+   C+   CVN   S+ C C  G RL++    C   R   C S
Sbjct: 238 PNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFS 297

Query: 614 THHG--CEHICVNNGNSYICKCSEG 636
              G  C      +     C C  G
Sbjct: 298 VLFGGRCAGDLAGHYTRRQCCCDRG 322



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 50/219 (22%)

Query: 469 CSEGFLINEDLKTCSR---VDYCLLS-DHGCEYSCVNMD--RSFACQCPEGHVLRSDGKT 522
           C EGF    +L TC+       C +S   GC  SC+N    R  +C C +G+     G  
Sbjct: 90  CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145

Query: 523 CAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRK---DVC--QAIDH 575
           C +     + D GC +   C+       C C  G++    G  C R      C  Q    
Sbjct: 146 CGQ----PICDRGCHNGGRCIGPNR---CACVYGFM----GPQCERDYRTGPCFGQVGPE 194

Query: 576 GCEH-----ICVNSDDSYT--------CE--------CLEGFRLAEDGKRCRRKDVCKST 614
           GC+H     +C  +    T        CE        C  GF        C+  D C++ 
Sbjct: 195 GCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAV 254

Query: 615 HHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
              C+   CVN   S+ C+C  G  L++    C+    G
Sbjct: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAG 293


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  277 bits (708), Expect = 4e-74
 Identities = 140/369 (37%), Positives = 193/369 (52%), Gaps = 17/369 (4%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN--CEQLCVNVPGSFVCQCYSGYA 310
           C N P SY C CK GY    +   C   D C  + +N  C   C+N+PG++ C C+ G+ 
Sbjct: 50  CQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFM 107

Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCA 366
           LA DG  C+ VD C   N GC+  CVNA GSY CQCH GF L+ ++ TC         C 
Sbjct: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCM 167

Query: 367 SSNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
           + +HGC H C  T     +C C  GF L  ++K C     C     GC+H C + +    
Sbjct: 168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPT 225

Query: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
           C CH+ Y L  +G+TC  ++ CA  + GC++ C +T     C C  GF +  D KTC  +
Sbjct: 226 CGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283

Query: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED 545
           + CL+++ GC++ C N   SF C C +G+ L +D +TC  +D C+  +  C+H C++S  
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTCDHICINSPG 342

Query: 546 SFVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
           SF C C  GYIL   G T C   D C   +  C+  CVN+  SY C C  G RL  +GK 
Sbjct: 343 SFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKD 400

Query: 605 CRRKDVCKS 613
           C     C S
Sbjct: 401 CVETGKCLS 409



 Score =  254 bits (649), Expect = 3e-67
 Identities = 129/368 (35%), Positives = 189/368 (51%), Gaps = 15/368 (4%)

Query: 286 EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE--NHGCEHECVNADGSYL 343
           +D + + +C N P S+ C C  GY    +GK+C  +D C ++  N GC HEC+N  G+Y 
Sbjct: 42  DDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYR 99

Query: 344 CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-RR 402
           C C +GF L  D   C  +D C  +N GCQ  CVN   SY C C  GF L+ ++ TC  R
Sbjct: 100 CTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHR 159

Query: 403 INY---CALNKPGCEHECVNMEES-YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC 458
            N    C     GC H C    +    C C  G+ L  N K C+    C   + GC+  C
Sbjct: 160 SNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSC 217

Query: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518
            +T+    C C + + ++ D +TC  ++ C +++ GC+ +C +      C CP G  L+ 
Sbjct: 218 EDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP 275

Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE 578
           DGKTC  ++ C + + GC+H C ++  SF C C +GY L  D +TC+  D C + +  C+
Sbjct: 276 DGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCD 334

Query: 579 HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFV 638
           HIC+NS  S+ C C  G+ L      C   D C  ++  C+  CVN   SY C C  G  
Sbjct: 335 HICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRR 393

Query: 639 LAEDGRRC 646
           L  +G+ C
Sbjct: 394 LHWNGKDC 401



 Score =  250 bits (639), Expect = 4e-66
 Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 13/328 (3%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
           C H CINIPG+Y C C  G++L  D   C   D C   +  C+Q+CVN  GS+ CQC+SG
Sbjct: 87  CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146

Query: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
           + L+++   C+        C +++HGC H C     G   C C  GF L  ++K CT   
Sbjct: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT- 205

Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
            C   N GCQH C +TD   +C C + + L+ D +TC  I  CA+N  GC+  C +    
Sbjct: 206 -CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATG 262

Query: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
             C C  G+TL P+GKTC  ++ C   + GC+  C NT  SF C C +G+ +  D +TC 
Sbjct: 263 VRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322

Query: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSCVS 542
            +D C   +  C++ C+N   SF C C  G++L   G T C  +D C++ +  C+  CV+
Sbjct: 323 DIDECSF-ERTCDHICINSPGSFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVN 379

Query: 543 SEDSFVCQCFEGYILREDGKTCRRKDVC 570
           ++ S+ C C  G  L  +GK C     C
Sbjct: 380 TKGSYECVCPPGRRLHWNGKDCVETGKC 407



 Score =  201 bits (510), Expect = 3e-51
 Identities = 100/299 (33%), Positives = 145/299 (48%), Gaps = 15/299 (5%)

Query: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPGCEHEC 417
           +D C+     C  +  C NT  SY C C  G+    + K C  I+ C  +    GC HEC
Sbjct: 34  VDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHEC 91

Query: 418 VNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE 477
           +N+  +Y C C  G+ L  +G  C  VD C   + GC+Q+C+N   S+ CQC  GF +++
Sbjct: 92  INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151

Query: 478 DLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDSCALG 532
           +  TC         C+  DHGC + C    +   AC C  G  L  + K C    +C  G
Sbjct: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL--TCNYG 209

Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
           + GC+HSC  ++    C C + Y L  DG+TC   + C   + GC+  C ++     C C
Sbjct: 210 NGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI--ETCAVNNGGCDRTCKDTATGVRCSC 267

Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
             GF L  DGK C+  + C   + GC+H C N   S+ C C +G+ L  D R C+   E
Sbjct: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE 326


>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
          Length = 499

 Score =  276 bits (707), Expect = 5e-74
 Identities = 146/344 (42%), Positives = 202/344 (58%), Gaps = 48/344 (13%)

Query: 591 ECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
           + ++ F L    + C R D+C    HGCE  CV+ G SY C C EG  L  DG+ C +C 
Sbjct: 200 DLIQEFGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCR 258

Query: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710
           EG +DLV ++DGSKS+  +NFE+VK+FV  I+D L +SP+  RVGL+Q+S++V TEF L 
Sbjct: 259 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 318

Query: 711 NFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770
            + +A ++K+AV  ++YM +G+MTGLAL+HM E SF++ +GARP +  VPR  +VFTDGR
Sbjct: 319 RYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 378

Query: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830
           +QDD+S WA++AK  GI MYAVGVGKA+E EL+EIASEP   H+ YA DF TM  + E L
Sbjct: 379 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 438

Query: 831 KKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPL 890
           +  IC                                 E+ +   T              
Sbjct: 439 RGSIC--------------------------------PEEGISAGT-------------- 452

Query: 891 EEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRL 934
            E    C+CE+L+ FQ      +  LT  L ++T R+E LEN+L
Sbjct: 453 -ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQL 495



 Score =  227 bits (578), Expect = 4e-59
 Identities = 111/235 (47%), Positives = 161/235 (68%)

Query: 43  QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
           Q  L    C     DLVF+IDSSRSV   ++  +++F++ +L+ L++GP+ TRVG++QY 
Sbjct: 20  QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79

Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
           S V++ F L+ F R+ ++ERA++ +  L+ GTMTGLAIQYA+N+AFS AEGARP  E VP
Sbjct: 80  SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139

Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
           RV +IVTDGRPQD VAEVAA+AR  GI I+A+GV + D  +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199

Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
             I+     FQ +LC   +C+ ++H C   C++   SY C C +G  L +D  +C
Sbjct: 200 DLIQEFGLQFQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 254



 Score =  169 bits (427), Expect = 1e-41
 Identities = 81/188 (43%), Positives = 126/188 (67%)

Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
           +C  GP+DLVFVID S+S+    FE ++QF+ G++  L + P A RVG++QYS+QV + F
Sbjct: 27  RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86

Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
            LR F+  +DM++A+  +  + +G+MTGLA+++    +F+  EGARP   RVPR A++ T
Sbjct: 87  PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146

Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
           DGR QD V+E A++A+A GI +YAVGV +A    L+ +AS P ++H+F  E F  + E  
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206

Query: 828 EKLKKGIC 835
            + +  +C
Sbjct: 207 LQFQSRLC 214



 Score =  155 bits (393), Expect = 1e-37
 Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)

Query: 51  CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
           C     DLV ++D S+SV   ++  VK F+  I+ FLD+ P+ TRVGL+Q+ S V+ EF 
Sbjct: 257 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 316

Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
           L  +   +EV++AV  + ++  GTMTGLA+++ +  +FSEA+GARP   NVPRV ++ TD
Sbjct: 317 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 376

Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
           GR QD ++  AA+A++ GI+++A+GVG+     L+ I SEP E HV    +F  +  L  
Sbjct: 377 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 436

Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
             +  +C     S    L   C    +           +   LN  Q T R++DL
Sbjct: 437 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 491



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 22/44 (50%), Positives = 29/44 (65%), Gaps = 1/44 (2%)

Query: 480 KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
           + C R D C   DHGCE+ CV+   S+ C CPEG  L++DGK+C
Sbjct: 212 RLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 254



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 23/51 (45%), Positives = 29/51 (56%), Gaps = 1/51 (1%)

Query: 516 LRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR 566
           L+   + C + D C   DHGCE  CVS   S+ C C EG  L+ DGK+C R
Sbjct: 207 LQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
           + L    + CV  D C   +HGCE +CV+   SY C C EG  L  D K+C +
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 20/53 (37%), Positives = 28/53 (52%), Gaps = 1/53 (1%)

Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRR 402
           F L    + C + D C   +HGC+ +CV+   SY C C +G  L  D K+C R
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 25/66 (37%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 432 YTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-----VD 486
           + L    + C R D C   DHGCE  C++   S+ C C EG  +  D K+C+R     VD
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVD 263

Query: 487 YCLLSD 492
             LL D
Sbjct: 264 LVLLVD 269



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 1/56 (1%)

Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR 443
           ++ F L    + C R + C     GCE +CV+   SY C C  G  L  +GK+C+R
Sbjct: 202 IQEFGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  276 bits (705), Expect = 8e-74
 Identities = 147/413 (35%), Positives = 210/413 (50%), Gaps = 21/413 (5%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GS+ CRC  G+ L+ ++  C   D C +    C   +CVN PGSF C+C+ GY  
Sbjct: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY-- 1146

Query: 312  AEDG----KRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
             E G    K C+ +D C      C    CVN +GS+ C C  G  L+P ++ C  I+ C+
Sbjct: 1147 -ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205

Query: 367  SSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
             S++ C++ +CVN   +Y C C  G+   PD++ C  I+ C +   GC+ +C N E SY 
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265

Query: 426  CRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
            C C  GY L P+G++C+ +D C      C+   C N    + C C +GF+ + D+KTC  
Sbjct: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325

Query: 485  VDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCV 541
            V+ C L+ + C +  C N   SF C C  G+ ++     C  +D C +G H C+   SC+
Sbjct: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385

Query: 542  SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTCECLEGFRLA 599
            +   SF C C EG+I   +G  C   D C    H C     CVN+  SY C C EGF   
Sbjct: 1386 NIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--T 1441

Query: 600  EDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
             DG  C   D C    + CE+  C+N   +Y C+C  GF  A D R C+   E
Sbjct: 1442 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE 1494



 Score =  259 bits (662), Expect = 8e-69
 Identities = 143/417 (34%), Positives = 205/417 (49%), Gaps = 16/417 (3%)

Query: 253  CINIPGSYVCRCKQGYILN-SDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYA 310
            C+N PGS+ C C +GY         C   D C      C    CVN  GSF C C  G+ 
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190

Query: 311  LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
            L+   + CV ++ C+  ++ C + +CVN  G+Y C C+ G+   PD++ CT ID C   N
Sbjct: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250

Query: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-HECVNMEESYYCRC 428
             GC  +C N++ SY C C +G+ L PD ++C  I+ C  N   C+  +C N+   Y C C
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLC 1310

Query: 429  HRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
            + G+    + KTC  V+ C    + C    C NT+ SF+C C  G+ + +    C+ VD 
Sbjct: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370

Query: 488  CLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
            C +  H C+   SC+N+  SF C C EG +   +G  C  LD C+ G H C     CV++
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNT 1428

Query: 544  EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDG 602
              S+ C C EG+    DG TC   D C    + CE+  C+N   +Y CEC  GF  A D 
Sbjct: 1429 PGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDS 1486

Query: 603  KRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE--GPIDLV 657
            + C+  D C   +      C N    + C C +G+ L   G  C    E   PI+ V
Sbjct: 1487 RSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543



 Score =  253 bits (645), Expect = 8e-67
 Identities = 142/422 (33%), Positives = 199/422 (47%), Gaps = 12/422 (2%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C+N  GS+ C C  G+ L+  +  C   + C++ D+ C    CVN+ G++ C C  GY  
Sbjct: 1174 CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233

Query: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
              D + C  +D C   N GC+ +C N++GSY C C EG+AL PD ++C  ID C ++   
Sbjct: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1293

Query: 372  CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCH 429
            C   +C N    Y C C  GF  + D KTC  +N C LN   C   EC N + S+ C C 
Sbjct: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQ 1353

Query: 430  RGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
             GY++      C+ VD C    H C+    CLN   SF C C EG++ N  +K C  +D 
Sbjct: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGN-GIK-CIDLDE 1411

Query: 488  CLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSE 544
            C    H C  +  CVN   S+ C C EG     DG TC+ +D CA   + CE+  C++  
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVP 1469

Query: 545  DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
             ++ C+C  G+    D ++C+  D C   +      C N    + C C +G+ L   G  
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529

Query: 605  CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSK 664
            C   D C    +    +CVN    Y C C   F L   G  C     G   L F   G  
Sbjct: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589

Query: 665  SL 666
            SL
Sbjct: 1590 SL 1591



 Score =  234 bits (598), Expect = 2e-61
 Identities = 139/443 (31%), Positives = 191/443 (43%), Gaps = 48/443 (10%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ---LCVNVPGSFVCQC 305
            CA  C+N  GSY C C  GY L  DQ  C+  D CA   H+CE    +C N+ G+F+C C
Sbjct: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323

Query: 306  YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----- 359
              G A   DG+ CV  + C ++   CE+  CVN  GSY C+C+EGF  +     C     
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383

Query: 360  ----------------------TKIDYCASSNHGCQHEC----VNTDDSYSCHCLKGFTL 393
                                  TK + C     G  H+C    +     Y   C  G   
Sbjct: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443

Query: 394  NPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
              D    R I+ C +    C + +C+N   S+ C C  GYT D +G +C  +D C+Q   
Sbjct: 2444 TTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500

Query: 453  GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
             C  +C NTE S+ C C  G+++ ED KTC  +D C    H C++ CVN    F C+CP 
Sbjct: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPP 2560

Query: 513  G----HVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
            G    H    D   C    S      G +  C ++  SF C+C  G+ L   G  C   D
Sbjct: 2561 GFTQHHTACIDNNECGSQPSLC----GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVD 2616

Query: 569  VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
             C   +H C+H C N    Y C C +G+       +C  ++ C + +      C N   S
Sbjct: 2617 ECDG-NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGS 2675

Query: 629  YICKCSEGFVLAEDGRRCKKCTE 651
            Y C C  GF   +    C    E
Sbjct: 2676 YKCACPSGFSFDQFSSACHDVNE 2698



 Score =  211 bits (538), Expect = 2e-54
 Identities = 135/460 (29%), Positives = 197/460 (42%), Gaps = 60/460 (13%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300
            C  +   C   C N  GSY C C +GY L  D  +C   D C      C+   C N+PG 
Sbjct: 1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305

Query: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
            + C CY G+  + D K C+ V+ C   ++ C   EC N  GS++C C  G+++      C
Sbjct: 1306 YRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365

Query: 360  TKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EH 415
            T +D C    H C     C+N   S+ C C +G+  N  K  C  ++ C+     C    
Sbjct: 1366 TDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINA 1423

Query: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474
            +CVN   SY C C  G+T D  G TCS VD CA+  + CE   CLN   ++ C+C  GF 
Sbjct: 1424 QCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481

Query: 475  INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
               D ++C  +D C   +     +C N+   F C C +G+ L   G  C  +D CA   +
Sbjct: 1482 PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN 1541

Query: 535  GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564
                 CV++   + C C   + L   G  C                              
Sbjct: 1542 CVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601

Query: 565  RRKDVCQAIDHGCEHIC-----VNSDDSYT-CECLEGFR------LAEDGKRCRR-KDVC 611
             R   C ++     + C     VNS + YT C   EGFR      + ED   C+    +C
Sbjct: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661

Query: 612  KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
            +  +      C+N   S+ C+C +G+ L+ED R C+   E
Sbjct: 1662 QGGN------CINTFGSFQCECPQGYYLSEDTRICEDIDE 1695



 Score =  211 bits (537), Expect = 3e-54
 Identities = 138/489 (28%), Positives = 209/489 (42%), Gaps = 97/489 (19%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTC---RIQDLCAMEDHNCEQLCVN-VPGSF---VCQC 305
            C+N  GS+ C C +G  L+     C   R++      D   E  C++ VPG F    C C
Sbjct: 971  CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD---EDECIHPVPGKFRMDACCC 1027

Query: 306  YSGYALAEDGKRCVA-------------------------------VDYCASENHGCEH- 333
              G A   + + C                                 ++ C +    C + 
Sbjct: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087

Query: 334  ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH------------------- 374
            +C N  GS+ C+C+ GFAL+ +++ CT ID C  S   C                     
Sbjct: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147

Query: 375  -------------------------ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
                                      CVNT+ S+ C C  G  L+P ++ C  IN C+L+
Sbjct: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLS 1207

Query: 410  KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
               C + +CVNM  +Y C C+ GY   P+ + C+ +D C   + GC+  C N+E S+ C 
Sbjct: 1208 DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS 1267

Query: 469  CSEGFLINEDLKTCSRVDYCLLSDHGCE-YSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527
            CSEG+ +  D ++C+ +D C  +   C+   C N+   + C C +G +   D KTC  ++
Sbjct: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327

Query: 528  SCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
             C L  + C    C +++ SF+C C  GY +++    C   D C+   H C+    C+N 
Sbjct: 1328 ECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387

Query: 585  DDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAED 642
              S+ C C EG+    +G +C   D C +  H C     CVN   SY C CSEGF    D
Sbjct: 1388 PGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGD 1443

Query: 643  GRRCKKCTE 651
            G  C    E
Sbjct: 1444 GFTCSDVDE 1452



 Score =  207 bits (528), Expect = 3e-53
 Identities = 119/380 (31%), Positives = 167/380 (43%), Gaps = 40/380 (10%)

Query: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
            C+N  GSF C+C  GY L   G RCV  D C+  N      C N  GS+ C C+EGF   
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG 2246

Query: 354  PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
            P    C  I+ CA +   C   C+NT  SY C C  G+ L  D+K C+ ++ CA     C
Sbjct: 2247 P-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305

Query: 414  EHE---CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQC 469
            E     C N+  ++ C C  G    P+G+ C   + C  +   CE   C+N   S+ C+C
Sbjct: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365

Query: 470  SEGFLINEDLKTC--SRVDYCLLS-----------------------------DHGCEYS 498
            +EGF  +     C  +R   C                                 H CE  
Sbjct: 2366 NEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC 2425

Query: 499  CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYIL 557
             +     +   CP G    +DG+    +D C +  + C +  C+++  SF C C  GY  
Sbjct: 2426 PLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTT 2482

Query: 558  REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG 617
               G +C   D C      C +IC N++ SY C C  G+ L EDGK C+  D C++  H 
Sbjct: 2483 DISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN 2542

Query: 618  CEHICVNNGNSYICKCSEGF 637
            C+ +CVN    + CKC  GF
Sbjct: 2543 CQFLCVNTLGGFTCKCPPGF 2562



 Score =  207 bits (527), Expect = 4e-53
 Identities = 138/452 (30%), Positives = 205/452 (45%), Gaps = 55/452 (12%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
            C N  GS++C C+ GY +    T C   D C +  HNC+    C+N+PGSF C C  G+ 
Sbjct: 1341 CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400

Query: 311  LAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
               +G +C+ +D C++  H C    +CVN  GSY C C EGF    D  TC+ +D CA +
Sbjct: 1401 --GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAEN 1456

Query: 369  NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427
             + C++ +C+N   +Y C C  GFT   D ++C+ I+ C+         C N+   ++C 
Sbjct: 1457 INLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI 1516

Query: 428  CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485
            C  GY LD  G  C+ +D CA   +    LC+NT   + C C   F +N     C  +RV
Sbjct: 1517 CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576

Query: 486  DYCLLS---DHGCEYSC-----VNMDRSFACQCPEGHVLRSDGKTCAKLDS------CAL 531
              C L          SC     V + RS +C C  G    +  +TC  ++S      C  
Sbjct: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRS-SCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635

Query: 532  GD--------------HGCEH--------SCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569
            G+                C+         +C+++  SF C+C +GY L ED + C   D 
Sbjct: 1636 GEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 1695

Query: 570  CQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG--CEHICVN 624
            C A    C    C N+  +YTC C   +     G  C   RK  C  +++G  CE+    
Sbjct: 1696 CFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPF 1755

Query: 625  NGNSYICKCSEGFVLAEDGRRCKKC-TEGPID 655
            N    +C C+     A + + C+ C T G  D
Sbjct: 1756 NVTKRMCCCTYNVGKAWN-KPCEPCPTPGTAD 1786



 Score =  188 bits (478), Expect = 2e-47
 Identities = 133/434 (30%), Positives = 186/434 (42%), Gaps = 37/434 (8%)

Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
           F   + G+ V    QG I+       +  D+C    + C    C+    S+ C+C  GY 
Sbjct: 467 FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYK 526

Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
              +G  C+ VD C S N     +CVN  GSY C+CH GF   P K+ C  ID C  +  
Sbjct: 527 QDANGD-CIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGV 584

Query: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
            C++  CVNTD S+ C C  GF L  D K C   + C          C+N + S+ C C 
Sbjct: 585 LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICK 644

Query: 430 RGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS------ 483
            G+ L PNG+ C+ VD C          C+N+E SF C C  G  +  D + C       
Sbjct: 645 PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704

Query: 484 ------RVDYCLLSDHGC----EYSCVNMDRSFA--CQ-CP-----EGHVLRSDGKTCA- 524
                 +   C+    G     E  C N D  F   CQ CP     E H L S G     
Sbjct: 705 TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV 764

Query: 525 ---KLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH- 579
               ++ CAL    C +  C +   S+ C C  GY     G+ C   D C      C++ 
Sbjct: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG 824

Query: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFV 638
           +C N+  SY+C C  G+    + + C   + C+S  + C +  C NN  S+ C+CS G  
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES--NPCVNGACRNNLGSFNCECSPGSK 882

Query: 639 LAEDGRRCKKCTEG 652
           L+  G  C    +G
Sbjct: 883 LSSTGLICIDSLKG 896



 Score =  187 bits (476), Expect = 3e-47
 Identities = 138/493 (27%), Positives = 202/493 (40%), Gaps = 86/493 (17%)

Query: 242  CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
            C  + + C+H  C+++ GSY C C  G+  + DQT C   D C  E H C    C N  G
Sbjct: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTVG 1953

Query: 300  SFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357
            S+ C CY G+ L  +   C+ +D C+S     C +  C N  GS+ C C+EG+ L PD K
Sbjct: 1954 SYNCLCYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012

Query: 358  TCTKIDYCAS-----SNHGCQH------------------------------------EC 376
             C   + C +     S   CQ+                                     C
Sbjct: 2013 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSC 2072

Query: 377  VNTDDSYSCHCLKGFTLNPDKKTC--RRINYCALN-----------------------KP 411
             NT   + C C  GF L+ + + C   R ++C  N                        P
Sbjct: 2073 TNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132

Query: 412  G------CEHECVNMEESYYCRCHRGYTLDPN-GKTCSRVDHCAQQDHGCEQ-LCLNTED 463
            G      CE    + E ++   C  G+   P+   T   V+ C +    C    C+NT+ 
Sbjct: 2133 GEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDG 2192

Query: 464  SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
            SF C+C  G+ ++     C   D C + +     +C N+  SF C C EG         C
Sbjct: 2193 SFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNC 2251

Query: 524  AKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH---I 580
              ++ CA     C   C+++  S+ C C  GY LRED K C+  D C    H CE    +
Sbjct: 2252 EDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311

Query: 581  CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVL 639
            C N   ++ C C  G     DG+ C  ++ C++    CE+  CVN   SY C+C+EGF  
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQS 2371

Query: 640  AEDGRRCKKCTEG 652
            +  G  C    +G
Sbjct: 2372 SSSGTECLDNRQG 2384



 Score =  182 bits (462), Expect = 1e-45
 Identities = 127/468 (27%), Positives = 191/468 (40%), Gaps = 69/468 (14%)

Query: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCV 295
           CT++ C+  +      C+N PGSY C+C  G+     +  C   D C      C+   CV
Sbjct: 539 CTSNPCTNGD------CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592

Query: 296 NVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD 355
           N  GSF C C +G+ L  DGK CV  D C + N      C+N DGS+ C C  GF L P+
Sbjct: 593 NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPN 652

Query: 356 KKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNK 410
            + CT +D C +        C+N++ S+ C C  G  +  D + C     R   Y  + K
Sbjct: 653 GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKK 712

Query: 411 PGC-----------EHECVNME---------------ESYYCRCHRGYTLDPNGKTCSRV 444
             C           E  C N +                 ++  C  G  +  +G+    +
Sbjct: 713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRD---I 769

Query: 445 DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNM 502
           + CA     C   +C N   S+ C C+ G+  +   + C  +D CL++   C+   C N 
Sbjct: 770 NECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNT 829

Query: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDG 561
             S++C CP G+V R++ +TC  ++ C    + C + +C ++  SF C+C  G  L   G
Sbjct: 830 PGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSKLSSTG 887

Query: 562 KTC--RRKDVC--QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-----K 612
             C    K  C     D  CE     +     C    G       +RC     C     +
Sbjct: 888 LICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR 947

Query: 613 STHHGCEHI--------------CVNNGNSYICKCSEGFVLAEDGRRC 646
                CE +              CVN+  S+ C+C EG  L   GR C
Sbjct: 948 IKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995



 Score =  182 bits (462), Expect = 1e-45
 Identities = 122/401 (30%), Positives = 172/401 (42%), Gaps = 46/401 (11%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GS+ C C +GY L  D   C   + C     +C    C N+ GSF C C  GY +
Sbjct: 1990 CFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEV 2049

Query: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----------- 359
              +   C+ ++ C  + + C    C N  G + C C  GF L+ + + C           
Sbjct: 2050 KSEN--CIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN 2107

Query: 360  --------------TKIDYCASSNHG------CQHECVNTDDSYSCHCLKGFTLNPDKKT 399
                          TK   C S   G      C+    + + ++   C  G    P    
Sbjct: 2108 FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHD 2167

Query: 400  CRR-INYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456
             R  +N C L  PG C + +C+N + S+ C C  GY LD  G  C   D C+  +     
Sbjct: 2168 TREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226

Query: 457  LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516
             C N   SF C C+EGF     +  C  ++ C  +   C + C+N   S+ C CP G+ L
Sbjct: 2227 TCTNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYAL 2285

Query: 517  RSDGKTCAKLDSCALGDHGCEH---SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573
            R D K C  LD CA G H CE     C +   +F+C C  G   R DG+ C  ++ C+  
Sbjct: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345

Query: 574  DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC 611
               CE+  CVN   SY CEC EGF+ +  G  C   R+ +C
Sbjct: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386



 Score =  182 bits (461), Expect = 2e-45
 Identities = 101/322 (31%), Positives = 145/322 (45%), Gaps = 12/322 (3%)

Query: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
            C  + + C +  CIN  GS+ C CK GY  +   T+C   D C+     C  +C N  GS
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512

Query: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
            + C C  GY L EDGK C  +D C ++ H C+  CVN  G + C+C  GF  +     C 
Sbjct: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH--HTACI 2570

Query: 361  KIDYCAS--SNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
              + C S  S  G +  C NT  S+SC C +GF+L+     C  ++ C  N   C+H C 
Sbjct: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR-CQHGCQ 2629

Query: 419  NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
            N+   Y C C +GY        C   + C+  +      C NT  S+ C C  GF  ++ 
Sbjct: 2630 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2689

Query: 479  LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA-----KLDSCALGD 533
               C  V+ C  S + C Y C N +  + C CP G+     G   +     K    +L  
Sbjct: 2690 SSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDT 2749

Query: 534  HGCEHSCVSSEDSFVCQCFEGY 555
               E + +S E  + C+   GY
Sbjct: 2750 EVDEENALSPEACYECK-INGY 2770



 Score =  181 bits (460), Expect = 2e-45
 Identities = 128/461 (27%), Positives = 189/461 (40%), Gaps = 70/461 (15%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTC--RIQDLCAM--EDHNCEQLCVNVPGSFV---CQC 305
            C N  GS+ C C  G  L+S    C   ++  C +  +D  CE   VN+ G+ +   C  
Sbjct: 866  CRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE---VNINGATLKSECCA 922

Query: 306  YSGYALAEDGKRCVAVDYC-----------ASENHGCE--------HECVNADGSYLCQC 346
              G A     +RC     C             + + CE          CVN+ GS+ C+C
Sbjct: 923  TLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCEC 982

Query: 347  HEGFALNPDKKTCTKID----YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-- 400
             EG  L+   + C  I     Y       C H         +C C  G     + + C  
Sbjct: 983  PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPK 1042

Query: 401  -----------------------------RRINYCALNKPGCEH-ECVNMEESYYCRCHR 430
                                         + IN C      C + +C N   S+ CRC+ 
Sbjct: 1043 PGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNS 1102

Query: 431  GYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLIN-EDLKTCSRVDYC 488
            G+ LD   + C+ +D C      C   +C+NT  SF C+C EG+      +K C  +D C
Sbjct: 1103 GFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDEC 1162

Query: 489  LLSDHGCE-YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDS 546
              +   C   +CVN + SF C CP GH L    + C  ++ C+L D+ C +  CV+   +
Sbjct: 1163 ERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGT 1222

Query: 547  FVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCR 606
            + C C  GY    D + C   D C  ++ GC+  C NS+ SY C C EG+ L  DG+ C 
Sbjct: 1223 YQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1282

Query: 607  RKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRC 646
              D C++    C+   C N    Y C C +GF+ + D + C
Sbjct: 1283 DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323



 Score =  157 bits (396), Expect = 6e-38
 Identities = 114/440 (25%), Positives = 170/440 (38%), Gaps = 65/440 (14%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C+N+PG+Y C C+ G+   SD  +C+  D C+ ++      C N+PG F C C  GY L 
Sbjct: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524

Query: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYC----- 365
              G  C  +D CA   +     CVN  G Y C C   F LNP    C   ++  C     
Sbjct: 1525 RTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG 1584

Query: 366  --ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
                 +  C  E        SC C  G       +TC  +N                   
Sbjct: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN----------------STE 1628

Query: 424  YYCRCHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLK 480
            YY  C  G    PN  T     +D C +    C+   C+NT  SF C+C +G+ ++ED +
Sbjct: 1629 YYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTR 1688

Query: 481  TCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKL--DSCALGDHG-- 535
             C  +D C      C   +C N   ++ C CP  ++  + G  C  +    C    +G  
Sbjct: 1689 ICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTT 1748

Query: 536  CEHSCVSSEDSFVCQC-----------------------------FEGYILREDGKTCRR 566
            CE+    +    +C C                               G+           
Sbjct: 1749 CENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808

Query: 567  KDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICV 623
             D C+ I   C + +C+N   S+ CEC  GF   +    C   D C +  + C+    C+
Sbjct: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868

Query: 624  NNGNSYICKCSEGFVLAEDG 643
            N+  SY C+C+ GF L+ +G
Sbjct: 1869 NSPGSYRCECAAGFKLSPNG 1888



 Score =  155 bits (392), Expect = 2e-37
 Identities = 127/466 (27%), Positives = 176/466 (37%), Gaps = 79/466 (16%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C N+PG + C C  GY L+     C   D CA   +    LCVN PG + C C   + L 
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565

Query: 313  EDGKRCV------------------------------AVDYCASENHGCEHEC-----VN 337
              G  CV                                  C S      + C     VN
Sbjct: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625

Query: 338  ADGSY-LCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNP 395
            +   Y LC   EGF  NP       ID C      CQ   C+NT  S+ C C +G+ L+ 
Sbjct: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685

Query: 396  DKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDH 452
            D + C  I+ C  +   C    C N   +Y C C   Y     G  C   R   C +  +
Sbjct: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745

Query: 453  G--CE---------QLCLNTED--------------------SFVCQCSEGFLINEDLKT 481
            G  CE         ++C  T +                      +C    GF  +     
Sbjct: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805

Query: 482  CSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539
               +D C      C    C+N   SF C+CP G         C  +D C+ GD+ C+ + 
Sbjct: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865

Query: 540  -CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597
             C++S  S+ C+C  G+ L  +G  C  ++ C  I + C H +CV+   SY C C  GF+
Sbjct: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924

Query: 598  LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAED 642
             ++D   C   D C+   H C +  C N   SY C C  GF L  +
Sbjct: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFELTHN 1968



 Score =  127 bits (319), Expect = 5e-29
 Identities = 79/270 (29%), Positives = 110/270 (40%), Gaps = 36/270 (13%)

Query: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLI 475
           C+    SY C C+ GY  D NG  C  VD C    + C    C+NT  S+ C+C  GF  
Sbjct: 510 CIPTVSSYRCECNMGYKQDANG-DCIDVDECT--SNPCTNGDCVNTPGSYYCKCHAGFQR 566

Query: 476 NEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
               + C  +D C+ +   C+   CVN D SF C C  G  L +DGK C   D C   + 
Sbjct: 567 TPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNM 626

Query: 535 GCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLE 594
                C++ + SF C C  G++L  +G+ C   D CQ         C+NS+ S+ C+C  
Sbjct: 627 CLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPP 686

Query: 595 GFRLAEDGKRC------------RRKDVCKSTHHG-------------------CEHICV 623
           G  +  DG+ C             +K VC     G                   C+    
Sbjct: 687 GLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPA 746

Query: 624 NNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
            N   +   CS G  +  DGR   +C   P
Sbjct: 747 KNSAEFHGLCSSGVGITVDGRDINECALDP 776



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 77/311 (24%), Positives = 111/311 (35%), Gaps = 67/311 (21%)

Query: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354
           NV GS F   C  G+     G +C+ V  C +                   C +GF   P
Sbjct: 87  NVCGSRFHSYCCPGWKTLPGGNQCI-VPICRNS------------------CGDGFCSRP 127

Query: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI---NYCALNKP 411
           +  TC+     ++       +C       S  C+ G T   D   C++     YC   +P
Sbjct: 128 NMCTCSSGQISSTCGSKSIQQC-------SVRCMNGGTCADDHCQCQKGYIGTYCG--QP 178

Query: 412 GCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
            CE+ C N         C C  G+T  P  +   R   C  Q +   Q+C       VC 
Sbjct: 179 VCENGCQNGGRCIGPNRCACVYGFT-GPQCERDYRTGPCFTQVNN--QMCQGQLTGIVCT 235

Query: 469 -------------------------CSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNM 502
                                    C  GF+ N     C  VD C      C+  +C+N 
Sbjct: 236 KTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINT 295

Query: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDG 561
             SF C+CP GH      + C  +D C++    CE   C ++  S+ C C  GY+   DG
Sbjct: 296 VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355

Query: 562 KTC--RRKDVC 570
             C  +R  +C
Sbjct: 356 SRCIDQRTGMC 366



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 11/166 (6%)

Query: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
           V  K LC    C+T+     H C   P      C++G+I N     C+  D C      C
Sbjct: 233 VCTKTLC----CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGIC 287

Query: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348
           +   C+N  GSF C+C +G+  +E  ++C  +D C+     CE  EC N  GSY C C  
Sbjct: 288 QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPR 347

Query: 349 GFALNPDKKTC----TKIDYCASSNHGCQHECVNTDDSYSCHCLKG 390
           G+  + D   C    T + +    N  C  E         C C  G
Sbjct: 348 GYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 69/257 (26%), Positives = 88/257 (34%), Gaps = 49/257 (19%)

Query: 426 CR--CHRGYTLDPNGKTCSR---VDHCAQQD-HGCEQLCLN--TEDSFVCQCSEGFLINE 477
           CR  C  G+   PN  TCS       C  +    C   C+N  T     CQC +G++   
Sbjct: 115 CRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGT- 173

Query: 478 DLKTCSRVDYCLLSDHGCEYSCVNMDRSFA---CQCPEGHVL------------------ 516
                    YC      CE  C N  R      C C  G                     
Sbjct: 174 ---------YC--GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNN 222

Query: 517 -----RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
                +  G  C K   CA       H C          C  G+I       C+  D CQ
Sbjct: 223 QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQ 281

Query: 572 AIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSY 629
           AI   C+   C+N+  S+ C C  G + +E  ++C   D C      CE   C N   SY
Sbjct: 282 AIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSY 341

Query: 630 ICKCSEGFVLAEDGRRC 646
            C C  G+V + DG RC
Sbjct: 342 FCVCPRGYVTSTDGSRC 358


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  273 bits (697), Expect = 7e-73
 Identities = 141/370 (38%), Positives = 191/370 (51%), Gaps = 17/370 (4%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDH-NCEQLCVNVPGSFVCQCYSGYAL 311
           C N P SY C CK GY    D   C+  D C  ED+  C   CVN+PG++ C CY G+ L
Sbjct: 46  CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103

Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
           A DG  C+ VD CA  N GC+  CVN  GSY C C EGF L+ ++ TC +       C +
Sbjct: 104 AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMN 163

Query: 368 SNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
            NHGC H C  T     +C C  GF L  +++ C+    C     GC+H C + E+   C
Sbjct: 164 KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRC 221

Query: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
            CH  + L  +GKTC  ++ CA  + GC+  C +      C C  GF++  D KTC  +D
Sbjct: 222 GCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDID 279

Query: 487 YCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDS 546
            C L++ GC++ C N   SF C C +G+ L  + + C  +D C+  D  C+H CV++  S
Sbjct: 280 ECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF-DRTCDHICVNTPGS 338

Query: 547 FVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEG-FRLAEDGKR 604
           F C C  GY+L   G T C   D C     GC   C+N+  SY C C  G  RL  +GK 
Sbjct: 339 FQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKD 396

Query: 605 CRRKDVCKST 614
           C     C+ +
Sbjct: 397 CTEPLKCQGS 406



 Score =  258 bits (659), Expect = 2e-68
 Identities = 141/382 (36%), Positives = 186/382 (48%), Gaps = 24/382 (6%)

Query: 281 DLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
           D C     NC  + +C N P S+ C C SGY    DGK C  VD C  E N GC H+CVN
Sbjct: 31  DECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCVN 88

Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
             G+Y C C++GF L  D   C  +D CA  N GCQ  CVN   SY CHC +GF L+ ++
Sbjct: 89  IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148

Query: 398 KTC----RRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
            TC         C     GC H C    +    C C  G+ L  N + C     C   + 
Sbjct: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNG 206

Query: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
           GC+  C +TE    C C   F+++ D KTC  ++ C +++ GC+  C +      C CP 
Sbjct: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPV 264

Query: 513 GHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQA 572
           G +L+ D KTC  +D C L + GC+H C ++  SF C C +GY L  + + C+  D C +
Sbjct: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-S 323

Query: 573 IDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICK 632
            D  C+HICVN+  S+ C C  G+ L      C   D C     GC   C+N   SY C 
Sbjct: 324 FDRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCT 382

Query: 633 CSEGFVLAEDGR---RCKKCTE 651
           C  G      GR     K CTE
Sbjct: 383 CPAG-----QGRLHWNGKDCTE 399



 Score =  235 bits (600), Expect = 1e-61
 Identities = 122/332 (36%), Positives = 170/332 (51%), Gaps = 18/332 (5%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
           C H C+NIPG+Y C C  G+ L  D   C   D CA  +  C+Q CVN+ GS+ C C  G
Sbjct: 82  CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREG 141

Query: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
           + L+++   C+        C ++NHGC H C     G   C+C  GF L  +++ C    
Sbjct: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200

Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
            C   N GCQH C +T+    C C   F L+ D KTC  I  CA+N  GC+ +C +    
Sbjct: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257

Query: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF--LINEDLKT 481
            +C C  G+ L P+ KTC  +D C   + GC+ +C NT  SF C C +G+  LINE  + 
Sbjct: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINE--RN 315

Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSC 540
           C  +D C   D  C++ CVN   SF C C  G++L   G T C  +D C++   GC   C
Sbjct: 316 CQDIDECSF-DRTCDHICVNTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGC 372

Query: 541 VSSEDSFVCQCFEGY-ILREDGKTCRRKDVCQ 571
           +++  S+ C C  G   L  +GK C     CQ
Sbjct: 373 INTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404



 Score =  216 bits (550), Expect = 8e-56
 Identities = 110/311 (35%), Positives = 160/311 (51%), Gaps = 13/311 (4%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC--RIQD--LCAMEDHNCEQLCVNV 297
           C+     C   C+N+ GSY C C++G+ L+ +Q TC  R ++   C  ++H C  +C   
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 175

Query: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
           P G   C+C  G+ L ++ + C     C   N GC+H C + +    C CH  F L+ D 
Sbjct: 176 PKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDG 233

Query: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
           KTC  I+ CA +N GC  +C +      C C  GF L PD+KTC+ I+ C LN  GC+H 
Sbjct: 234 KTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHI 291

Query: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
           C N   S+ C C +GY L  N + C  +D C+  D  C+ +C+NT  SF C C  G+L+ 
Sbjct: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCDHICVNTPGSFQCLCHRGYLL- 349

Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHG 535
             +  C  VD C ++  GC + C+N   S+ C CP G   L  +GK C +   C  G  G
Sbjct: 350 YGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPG 408

Query: 536 CEHSCVSSEDS 546
              + +S   S
Sbjct: 409 ASKAMLSCNRS 419



 Score =  202 bits (513), Expect = 2e-51
 Identities = 104/307 (33%), Positives = 155/307 (50%), Gaps = 14/307 (4%)

Query: 357 KTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL-NKPGC 413
           K    +D C      C  +  C NT  SY C C  G+T   D K C+ ++ C   +  GC
Sbjct: 25  KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGC 82

Query: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
            H+CVN+  +Y C C+ G+ L  +G  C  VD CA+ + GC+Q C+N   S+ C C EGF
Sbjct: 83  VHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGF 142

Query: 474 LINEDLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDS 528
            ++++  TC +       C+  +HGC + C    +   AC+C  G  L  + + C KL +
Sbjct: 143 FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC-KL-T 200

Query: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSY 588
           C  G+ GC+H+C  +E    C C   ++L  DGKTC   + C   + GC+  C ++    
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAATGV 258

Query: 589 TCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
            C C  GF L  D K C+  D C+  + GC+HIC N   S+ C C +G+ L  + R C+ 
Sbjct: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318

Query: 649 CTEGPID 655
             E   D
Sbjct: 319 IDECSFD 325



 Score =  114 bits (285), Expect = 4e-25
 Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 13/219 (5%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
           C+     C   C +      C C  G++L  D+ TC+  D C + +  C+ +C N  GSF
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSF 299

Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
            C C  GY L  + + C  +D C S +  C+H CVN  GS+ C CH G+ L      C  
Sbjct: 300 ECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCHRGYLLY-GITHCGD 357

Query: 362 IDYCASSNHGCQHECVNTDDSYSCHCLKG-FTLNPDKKTCRRINYCALNKPGCEHECVNM 420
           +D C+ +  GC+  C+NT  SY C C  G   L+ + K C     C    PG     ++ 
Sbjct: 358 VDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPGASKAMLS- 415

Query: 421 EESYYCRCHRGYTLDPNGKTC-SRVDHCAQQDHGCEQLC 458
                  C+R    D    TC SR     + ++G    C
Sbjct: 416 -------CNRSGKKDTCALTCPSRARFLPESENGFTVSC 447


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  255 bits (652), Expect = 1e-67
 Identities = 133/388 (34%), Positives = 189/388 (48%), Gaps = 42/388 (10%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME-DHNCEQLCVNVPGSFVCQCYSGYAL 311
           C N P SY C CK GY    +   C   D C  E +  C   C+N+PG++ C C+ G+ L
Sbjct: 62  CQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML 119

Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
           A DG  C+ VD C   N GC+H CVN  GSY C C EGF L+ ++ TC         C +
Sbjct: 120 AHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179

Query: 368 SNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
            +HGC H C      S +C C  GF L  +++ C  I  C     GC+H C +  +   C
Sbjct: 180 KDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPEC 237

Query: 427 RCHRGYTLDPNGKTCSR----------------------------VDHCAQQDHGCEQLC 458
            CH  Y +  +G++C                              ++ CA  + GC++ C
Sbjct: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297

Query: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518
            +T     C C  GF +  D KTC  +D C   + GC++ C N+  SF C C +G  L +
Sbjct: 298 KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLT 357

Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT-CRRKDVCQAIDHGC 577
           D K+C  +D C+L D  C+HSC++   +F C C  GY L   G T C   + C   + GC
Sbjct: 358 DEKSCQDVDECSL-DRTCDHSCINHPGTFACACNRGYTLY--GFTHCGDTNECSINNGGC 414

Query: 578 EHICVNSDDSYTCECLEGFRLAEDGKRC 605
           + +CVN+  SY C+C  G++L  + K C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442



 Score =  245 bits (626), Expect = 1e-64
 Identities = 128/402 (31%), Positives = 192/402 (47%), Gaps = 42/402 (10%)

Query: 281 DLCA--MEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
           D CA  ++D + + LC N P S+ C C  GY    +G++C  +D C +E N GC H+C+N
Sbjct: 47  DECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLN 104

Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
             G+Y C C +GF L  D   C  +D C  +N GCQH CVN   SY C C +GF L+ ++
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQ 164

Query: 398 KTCRRIN----YCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
            TC   +     C     GC H C      S  C C  G+ L  N + C  +  C   + 
Sbjct: 165 HTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNG 222

Query: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR---------------------------- 484
           GC+  C +T D   C C   + ++ D ++C                              
Sbjct: 223 GCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLL 282

Query: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
           ++ C +++ GC+ +C +      C CP G  L+ DGKTC  +D C   + GC+H C +  
Sbjct: 283 METCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIV 342

Query: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
            SF C C +G+ L  D K+C+  D C ++D  C+H C+N   ++ C C  G+ L      
Sbjct: 343 GSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTL-YGFTH 400

Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
           C   + C   + GC+ +CVN   SY C+C  G+ L  + + C
Sbjct: 401 CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442



 Score =  235 bits (600), Expect = 1e-61
 Identities = 122/354 (34%), Positives = 175/354 (49%), Gaps = 39/354 (11%)

Query: 245 LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ 304
           L   C H C+NIPG+Y C C  G++L  D   C   D C   +  C+  CVNV GS+ C 
Sbjct: 94  LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC 153

Query: 305 CYSGYALAEDGKRCVAVD----YCASENHGCEHECVNAD-GSYLCQCHEGFALNPDKKTC 359
           C  G+ L+++   C+        C +++HGC H C  A  GS  C+C  GF L  +++ C
Sbjct: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213

Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC------------------- 400
             I  C   N GCQH C +T D   C C   + ++ D ++C                   
Sbjct: 214 --ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271

Query: 401 -------RRI--NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
                  RR+    CA+N  GC+  C +     +C C  G+TL  +GKTC  +D C  ++
Sbjct: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331

Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
            GC+  C N   SF C C +GF +  D K+C  VD C L D  C++SC+N   +FAC C 
Sbjct: 332 GGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL-DRTCDHSCINHPGTFACACN 390

Query: 512 EGHVLRSDGKT-CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
            G+ L   G T C   + C++ + GC+  CV++  S+ CQC  GY L  + K C
Sbjct: 391 RGYTLY--GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442



 Score =  191 bits (485), Expect = 3e-48
 Identities = 100/330 (30%), Positives = 150/330 (45%), Gaps = 40/330 (12%)

Query: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN-KPGCEHECV 418
           +D CA     C  +  C NT  SY C C  G+    + + C  I+ C      GC H+C+
Sbjct: 46  VDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCL 103

Query: 419 NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
           N+  +Y C C  G+ L  +G  C  VD C + + GC+  C+N   S+ C C EGF ++++
Sbjct: 104 NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN 163

Query: 479 LKTCSRVDY----CLLSDHGCEYSCVNMDR-SFACQCPEGHVLRSDGKTCAKLDSCALGD 533
             TC         C+  DHGC + C    R S AC+C  G  L  + + C  + +C  G+
Sbjct: 164 QHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGN 221

Query: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD------------------------- 568
            GC+HSC  + D   C C   Y +  DG++C  ++                         
Sbjct: 222 GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281

Query: 569 ---VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNN 625
               C   + GC+  C ++     C C  GF L  DGK C+  D C++ + GC+H C N 
Sbjct: 282 LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341

Query: 626 GNSYICKCSEGFVLAEDGRRCKKCTEGPID 655
             S+ C C +GF L  D + C+   E  +D
Sbjct: 342 VGSFDCGCKKGFKLLTDEKSCQDVDECSLD 371



 Score =  173 bits (439), Expect = 6e-43
 Identities = 88/274 (32%), Positives = 131/274 (47%), Gaps = 35/274 (12%)

Query: 242 CSTLEHNCAHFCINIP-GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
           C   +H C+H C   P GS  C C+ G+ L  +Q  C +   C   +  C+  C +    
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL--TCNHGNGGCQHSCDDTADG 234

Query: 301 FVCQCYSGYALAEDGKRC----------------------------VAVDYCASENHGCE 332
             C C+  Y +  DG+ C                            + ++ CA  N GC+
Sbjct: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294

Query: 333 HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFT 392
             C +      C C  GF L  D KTC  ID C + N GC H C N   S+ C C KGF 
Sbjct: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFK 354

Query: 393 LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKT-CSRVDHCAQQD 451
           L  D+K+C+ ++ C+L++  C+H C+N   ++ C C+RGYTL   G T C   + C+  +
Sbjct: 355 LLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINN 411

Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
            GC+Q+C+NT  S+ CQC  G+ ++ + K C  V
Sbjct: 412 GGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445



 Score =  119 bits (299), Expect = 1e-26
 Identities = 68/218 (31%), Positives = 94/218 (43%), Gaps = 20/218 (9%)

Query: 234 KKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293
           K+      C+     C   C +      C C  G+ L  D  TC+  D C   +  C+  
Sbjct: 278 KRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF 337

Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
           C N+ GSF C C  G+ L  D K C  VD C S +  C+H C+N  G++ C C+ G+ L 
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTLY 396

Query: 354 PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
                C   + C+ +N GCQ  CVNT  SY C C  G+ L+ +KK C  +        G 
Sbjct: 397 -GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK-------GL 448

Query: 414 EHECVNMEESYYC-----------RCHRGYTLDPNGKT 440
               V+   S +C           RCH G  L  +  T
Sbjct: 449 LPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTT 486


>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
          Length = 1541

 Score =  249 bits (637), Expect = 6e-66
 Identities = 133/357 (37%), Positives = 174/357 (48%), Gaps = 24/357 (6%)

Query: 261 VCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVN----VPGSFV-CQCYSGYALAEDG 315
           V RC +G++   D+  C   +  A        LC +    VPGS   C C  G+     G
Sbjct: 107 VLRCCRGWMQQPDEEGCLSAECSA-------SLCFHGGRCVPGSAQPCHCPPGF----QG 155

Query: 316 KRC-VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH 374
            RC   VD C + N GC+H CVN  GSYLC+C  GF L+ D +TC  I+ CA  N GCQH
Sbjct: 156 PRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQH 215

Query: 375 ECVN-TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
            CV  T   + C C  GF L  D + C R + CA     C H C  +     C CH GY 
Sbjct: 216 HCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQ 275

Query: 434 LDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY-----C 488
           L  +GK C  VD CA     C   CLNT+ SF C C  G+ +  D + C R++      C
Sbjct: 276 LAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSC 335

Query: 489 LLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFV 548
             ++ GC + C +      C CP G+ L +D +TC  +D CA     C+  C ++   + 
Sbjct: 336 EANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA-DSPCCQQVCTNNPGGYE 394

Query: 549 CQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 605
           C C+ GY L  DG  C   D C +   GCEH C N   S+ C C  G+RL ED + C
Sbjct: 395 CGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 451



 Score =  242 bits (617), Expect = 1e-63
 Identities = 128/363 (35%), Positives = 173/363 (47%), Gaps = 16/363 (4%)

Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDKKTC 359
           V +C  G+    D + C++ +  AS    C H   CV       C C  GF      +  
Sbjct: 107 VLRCCRGWMQQPDEEGCLSAECSASL---CFHGGRCVPGSAQP-CHCPPGFQ---GPRCQ 159

Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
             +D C + N GCQH CVNT  SY C C  GF L+ D +TC  IN CAL   GC+H CV 
Sbjct: 160 YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219

Query: 420 MEESYY-CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
           +  + + C+C  G+ L  +G+ C R   CA ++  C   C        C+C  G+ +  D
Sbjct: 220 LTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAAD 279

Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-----SCALGD 533
            K C  VD C      C + C+N   SF C C  G+ L +DG+ C +++     SC   +
Sbjct: 280 GKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANN 339

Query: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECL 593
            GC H C  +    +C C  GY L  D +TC   D C A    C+ +C N+   Y C C 
Sbjct: 340 GGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDC-ADSPCCQQVCTNNPGGYECGCY 398

Query: 594 EGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
            G+RL+ DG  C   D C S+  GCEH C N   S+ C C  G+ L ED R C    E  
Sbjct: 399 AGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPM 458

Query: 654 IDL 656
           +DL
Sbjct: 459 VDL 461



 Score =  239 bits (610), Expect = 9e-63
 Identities = 143/446 (32%), Positives = 198/446 (44%), Gaps = 44/446 (9%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS- 300
           C T    C H C+N PGSY+C CK G+ L++D  TC   + CA+ +  C+  CV +  + 
Sbjct: 165 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITR 224

Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
             CQC  G+ L EDG+ CV    CA+ N  C H C    G   C+CH G+ L  D K C 
Sbjct: 225 HRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE 284

Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI-----NYCALNKPGCEH 415
            +D CA+    C H C+NT  S+ C C  G+ L  D + C RI     N C  N  GC H
Sbjct: 285 DVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH 344

Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
            C +      C C RGY LD + +TC  VD CA     C+Q+C N    + C C  G+ +
Sbjct: 345 GCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP-CCQQVCTNNPGGYECGCYAGYRL 403

Query: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
           + D   C  VD C  S  GCE+ C N+  SF C C  G+ L  D + C+ L+   +   G
Sbjct: 404 SADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDG 463

Query: 536 -------CEHSCVSSEDSFVCQCFEGYILREDGK--------TCRRKDVC--QAIDHGCE 578
                    H  V  ++  + Q F+   +  D +        T   K VC   +  H C 
Sbjct: 464 ELPFVRPLPHIAVLQDE--LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCS 521

Query: 579 HICVNSDDSYT-------CECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGN---- 627
             C +  +  T       C+C EG+      + C      K+    C   C N G     
Sbjct: 522 LTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCS--CQNGGTCDSV 579

Query: 628 SYICKCSEGFVLAEDGRRCKK-CTEG 652
           +  C+C  G      G  C+  C +G
Sbjct: 580 TGACRCPPGV----SGTNCEDGCPKG 601



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/514 (24%), Positives = 160/514 (31%), Gaps = 137/514 (26%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
           C   C N PG Y C C  GY L++D   C   D CA     CE  C N+ GSF C C +G
Sbjct: 382 CQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAG 441

Query: 309 YALAEDGKRC----------------------VAV------------------------- 321
           Y L ED + C                      +AV                         
Sbjct: 442 YRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRG 501

Query: 322 DYCASENHGCEHECVNADGSYLCQ-CHEGFA--LNPDKKTCTKIDYCASSNHGCQHECVN 378
           ++  +E   C  +    D S  C  C  G    L  D   C +       N  C  +   
Sbjct: 502 EHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFG 561

Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG--CEHECVNMEESYYCR--------- 427
            + S+SC C  G T +     CR    C     G  CE  C       +CR         
Sbjct: 562 KNCSFSCSCQNGGTCDSVTGACR----CPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRG 617

Query: 428 -CHRGY---TLDPN---------------GKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
            CHR Y     DP                G  CS    C Q      Q C   + S  C 
Sbjct: 618 RCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPH---TQSCDKRDGS--CS 672

Query: 469 CSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKL-- 526
           C  GF          R + C      CE          AC CP G    S    C K   
Sbjct: 673 CKAGF----------RGERCQAE---CELGYFGPGCWQACTCPVGVACDSVSGECGKRCP 719

Query: 527 ---------DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV-------- 569
                      C +G  G   S   S     C    G      G+T    +         
Sbjct: 720 AGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWG 779

Query: 570 --CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEH--ICV 623
             CQ I   C+H      ++  C CL GF     G RC  +DVC +  +G  C+    C 
Sbjct: 780 LGCQEICPACQHAARCDPETGACLCLPGF----VGSRC--QDVCPAGWYGPSCQTRCSCA 833

Query: 624 NNGNSY----ICKCSEGFVLAEDGRRCKKCTEGP 653
           N+G+ +     C C+ G+      R C     GP
Sbjct: 834 NDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGP 867



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 107/456 (23%), Positives = 154/456 (33%), Gaps = 99/456 (21%)

Query: 249  CAH--FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306
            C H   C ++ G+  C C  G+      T C           +C   C N      C   
Sbjct: 919  CQHGAACDHVSGA--CTCPAGW----RGTFCEHACPAGFFGLDCRSAC-NCTAGAACDAV 971

Query: 307  SGYALAEDGKRCV-AVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC------ 359
            +G  L   G+R     + C +  +G  H C  A     C C  G + +P    C      
Sbjct: 972  NGSCLCPAGRRGPRCAETCPAHTYG--HNCSQA-----CACFNGASCDPVHGQCHCAPGW 1024

Query: 360  ---TKIDYCASSNHG--CQHECV----NTDDSYS--CHCLKGFTLNPDKKTC--RRINYC 406
               + +  C +  +G  C+H C+     T D  S  C C +G+     +K C  R +   
Sbjct: 1025 MGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAG 1084

Query: 407  ALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR---VDHCAQQDHGCEQLCLNTED 463
              +  GC +  +    +  C C  G+T D     C R    + CAQ+   C         
Sbjct: 1085 CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR-CSCPPGAACHHV 1143

Query: 464  SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC----VNMDRSFACQCP-EGHVLRS 518
            +  C+C  GF                 +  GCE +C       D +  CQCP E      
Sbjct: 1144 TGACRCPPGF-----------------TGSGCEQACPPGSFGEDCAQMCQCPGENPACHP 1186

Query: 519  DGKTCAKLDSCALGDH---------------GCEHSC------VSSEDSFVCQCFEGYIL 557
               TC    SCA G H               GCE  C           +  C+C  G++ 
Sbjct: 1187 ATGTC----SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLG 1242

Query: 558  REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK---RCRRKDVCKST 614
             +   TC +          C H+C        C+ + G  L   G+   RC R       
Sbjct: 1243 TDCNLTCPQ----GRFGPNCTHVC-GCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRF 1297

Query: 615  HHGCEHICVNNGNSYICKCSEGFV---LAEDGRRCK 647
              GCEH C +  N  +C  S G     L   GR C+
Sbjct: 1298 GVGCEHTC-SCRNGGLCHASNGSCSCGLGWTGRHCE 1332



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 118/516 (22%), Positives = 165/516 (31%), Gaps = 145/516 (28%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQ---------TTCRIQDLCAMEDH---- 288
            C  +   C H     P +  C C  G++ +  Q          +C+ +  CA + H    
Sbjct: 782  CQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPA 841

Query: 289  --------------------------NCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
                                      +C   C    G   C   SG  L E G      +
Sbjct: 842  TGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCE 901

Query: 323  YCASENH---GCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG--CQHEC- 376
                + H   GCE           CQC  G A +     CT    C +   G  C+H C 
Sbjct: 902  QQCPQGHFGPGCEQR---------CQCQHGAACDHVSGACT----CPAGWRGTFCEHACP 948

Query: 377  ---VNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNKPG--CEHECVNMEESYYC 426
                  D   +C+C  G   +    +C     RR   CA   P     H C     S  C
Sbjct: 949  AGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNC-----SQAC 1003

Query: 427  RCHRGYTLDPNGKTCSRVDHCAQQDHG--CEQLCL------NTEDSFVCQ---------- 468
             C  G + DP    C    HCA    G  C Q C       N   S +CQ          
Sbjct: 1004 ACFNGASCDPVHGQC----HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSG 1059

Query: 469  ---CSEGFLINEDLKTCSRVDYCLLSDHGCEYS--CVN----MDRSFACQCPEGHV---- 515
               C EG+      K C   D       GC +S  C+N       +  C CP G      
Sbjct: 1060 HCACPEGWAGLACEKECLPRDV----RAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKC 1115

Query: 516  ----LRS-DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
                LR   G+ CA+  SC  G   C H       +  C+C  G+     G  C +    
Sbjct: 1116 QSPCLRGWFGEACAQRCSCPPG-AACHHV------TGACRCPPGF----TGSGCEQACPP 1164

Query: 571  QAIDHGCEHICVNSDD-------SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHI-- 621
             +    C  +C    +       + TC C  G+     G  C+++        GCE +  
Sbjct: 1165 GSFGEDCAQMCQCPGENPACHPATGTCSCAAGYH----GPSCQQRCPPGRYGPGCEQLCG 1220

Query: 622  CVNNGN----SYICKCSEGFVLAEDGRRCKKCTEGP 653
            C+N G+    +  C+C  GF+  +    C +   GP
Sbjct: 1221 CLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGP 1256



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 104/427 (24%), Positives = 132/427 (30%), Gaps = 101/427 (23%)

Query: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
           S+ C C+ G   +S    CR      +   NCE             C  GY     GK C
Sbjct: 565 SFSCSCQNGGTCDSVTGACRCPP--GVSGTNCED-----------GCPKGYY----GKHC 607

Query: 319 VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
                CA  N G  H    A     C C  G        TC    +      GC  EC  
Sbjct: 608 RKKCNCA--NRGRCHRLYGA-----CLCDPGLYGRFCHLTCPPWAF----GPGCSEEC-- 654

Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY-------CRCHRG 431
                   C++  T + DK+              C+ EC   E  Y+       C C  G
Sbjct: 655 -------QCVQPHTQSCDKRDGSCSCKAGFRGERCQAEC---ELGYFGPGCWQACTCPVG 704

Query: 432 YTLDPNGKTCSRVDHCAQQDHGCEQLC----LNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
              D     C +      Q   C Q C         S  C C  G   +     C     
Sbjct: 705 VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCG-GAPCHGVTGQCR---- 759

Query: 488 CLLSDHG--CEYSCVNMDRSFACQ--CPE-GHVLRSDGKTCAKL-----------DSCAL 531
           C     G  CE  C        CQ  CP   H  R D +T A L           D C  
Sbjct: 760 CPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPA 819

Query: 532 GDHG--CEHSCVSSEDSFV------CQCFEGYILREDGKTCRRKDVCQAIDHG--CEHIC 581
           G +G  C+  C  + D         C C  G+     G +C+R   C     G  C H C
Sbjct: 820 GWYGPSCQTRCSCANDGHCHPATGHCSCAPGWT----GFSCQR--ACDTGHWGPDCSHPC 873

Query: 582 VNSDDSYTCECLEGFRLAED---GKRCRRKDVCKSTHHG--------CEHICVNNGNSYI 630
             S    +C+ + G  L E    G RC ++  C   H G        C+H    +  S  
Sbjct: 874 NCSAGHGSCDAISGLCLCEAGYVGPRCEQQ--CPQGHFGPGCEQRCQCQHGAACDHVSGA 931

Query: 631 CKCSEGF 637
           C C  G+
Sbjct: 932 CTCPAGW 938



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 87/355 (24%), Positives = 111/355 (31%), Gaps = 82/355 (23%)

Query: 257  PGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF------VCQCYSGYA 310
            P +  C C  GY   S Q  C            CEQLC  + G         C+C +G+ 
Sbjct: 1186 PATGTCSCAAGYHGPSCQQRCPP----GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFL 1241

Query: 311  LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCAS--S 368
                G  C         N  C       + +++C C +G A +P   TC      A    
Sbjct: 1242 ----GTDC---------NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRC 1288

Query: 369  NHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG--CEHEC----VNMEE 422
              GC          ++C C  G   +    +C     C L   G  CE  C         
Sbjct: 1289 ERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCS----CGLGWTGRHCELACPPGRYGAAC 1344

Query: 423  SYYCRCHRGYTLDPNGKTC--------SRVDH-CAQQDH--GCEQLCLNTED------SF 465
               C CH   T +P   TC           +H C    H  GC+ LC           S 
Sbjct: 1345 HLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISG 1404

Query: 466  VCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ-------CPEGHVLRS 518
             C C  GF  +   + C    +      GC   C + D    C        CP G     
Sbjct: 1405 RCLCPAGFHGHFCERGCEPGSF----GEGCHQRC-DCDGGAPCDPVTGLCLCPPGR---- 1455

Query: 519  DGKTCAKLDSCALGDHG--------CEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
             G TC  LD C  G  G        C         S  C C +GY+    G TCR
Sbjct: 1456 SGATC-NLD-CRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYM----GPTCR 1504


>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
          Length = 496

 Score =  246 bits (629), Expect = 5e-65
 Identities = 137/332 (41%), Positives = 191/332 (57%), Gaps = 63/332 (18%)

Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG----PIDLVFVI 660
           C   D+C +  H CE +C+++  SY C C EGF L  DG+ C  C+ G      DLVF+I
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280

Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
           DGSKS+  ENFE+VK+F++ I+D+L +S K A+VGL+QYS+ V  EF L  F++ KD+K 
Sbjct: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340

Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
           AV +M YM KG+MTG ALK++ + SFT   GARP + +V    IVFTDGR+QD +++ A 
Sbjct: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKV---GIVFTDGRSQDYINDAAK 397

Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
           KAK  G  M+AVGVG A+E+EL+EIASEP  +H FY  DF T+++I +KL+K IC     
Sbjct: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC----- 452

Query: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
                                      EED                          C CE
Sbjct: 453 --------------------------VEED-------------------------PCACE 461

Query: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALEN 932
           +L+ FQ      ++ LT++LE +++R+  LEN
Sbjct: 462 SLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493



 Score =  243 bits (619), Expect = 8e-64
 Identities = 126/273 (46%), Positives = 179/273 (65%), Gaps = 21/273 (7%)

Query: 8   CFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRS 67
           C LL+L Q +  P  A +       SRG   RT P              DLVF++DSSRS
Sbjct: 12  CSLLLLLQALCSPGLAPQ-------SRGHLCRTRP-------------TDLVFVVDSSRS 51

Query: 68  VNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRM 127
           V   ++ KVK F+  +++ LD+GP+ TRVG++ Y STVK EFSL+    K+ + +AV+R+
Sbjct: 52  VRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRI 111

Query: 128 RHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDT 187
           + LSTGTMTGLAIQ+A+  AF +AEG R    ++ +V+++VTDGRPQDSV +V+A+AR +
Sbjct: 112 QPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARAS 171

Query: 188 GILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLC-TAHMCSTLE 246
           G+ +FAIGVG VD  TL+ I SEP ++HV  V ++S IE L+  FQ+  C  + +C+T +
Sbjct: 172 GVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGD 231

Query: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRI 279
           H+C   CI+ PGSY C C +G+ LNSD  TC +
Sbjct: 232 HDCEQVCISSPGSYTCACHEGFTLNSDGKTCNV 264



 Score =  153 bits (386), Expect = 8e-37
 Identities = 76/203 (37%), Positives = 125/203 (61%), Gaps = 3/203 (1%)

Query: 633 CSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAA 692
           CS G      G  C+     P DLVFV+D S+S+    FE VK F++ +I+SL + P A 
Sbjct: 22  CSPGLAPQSRGHLCRT---RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNAT 78

Query: 693 RVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGA 752
           RVG++ Y++ V  EF+LR   S   + +AV  ++ +  G+MTGLA++    ++F   EG 
Sbjct: 79  RVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGG 138

Query: 753 RPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNK 812
           R  S  + +  IV TDGR QD V + +++A+A+G+ ++A+GVG   +  L++IASEP ++
Sbjct: 139 RSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDE 198

Query: 813 HLFYAEDFSTMDEISEKLKKGIC 835
           H+ Y E +S ++++S K ++  C
Sbjct: 199 HVDYVESYSVIEKLSRKFQEAFC 221



 Score =  147 bits (371), Expect = 5e-35
 Identities = 74/181 (40%), Positives = 113/181 (62%), Gaps = 3/181 (1%)

Query: 57  DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
           DLVF+ID S+SV   ++  VK+FI  I+  LD+   + +VGL+QY S+V+ EF L  F  
Sbjct: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334

Query: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
           K +++ AV+ M ++  GTMTG A++Y ++ +F+ + GARP      +V ++ TDGR QD 
Sbjct: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP---GAQKVGIVFTDGRSQDY 391

Query: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
           + + A KA+D G  +FA+GVG    + L+ I SEP  +H F  A+F  I  +    QKK+
Sbjct: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451

Query: 237 C 237
           C
Sbjct: 452 C 452



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 24/42 (57%), Positives = 29/42 (69%)

Query: 318 CVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
           CV  D CA+ +H CE  C+++ GSY C CHEGF LN D KTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 23/42 (54%), Positives = 26/42 (61%)

Query: 523 CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
           C   D CA GDH CE  C+SS  S+ C C EG+ L  DGKTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 3/49 (6%)

Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA 407
           C   D CA+ +H C+  C+++  SY+C C +GFTLN D KTC   N C+
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC---NVCS 266



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 21/43 (48%), Positives = 28/43 (65%)

Query: 441 CSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
           C   D CA  DH CEQ+C+++  S+ C C EGF +N D KTC+
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCN 263



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 20/42 (47%), Positives = 23/42 (54%)

Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
           C   D C   DH CE  C++   S+ C C EG  L SDGKTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 2/70 (2%)

Query: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432
           Q E V+  +SYS   ++  +    +  C   + CA     CE  C++   SY C CH G+
Sbjct: 196 QDEHVDYVESYSV--IEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253

Query: 433 TLDPNGKTCS 442
           TL+ +GKTC+
Sbjct: 254 TLNSDGKTCN 263


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  245 bits (625), Expect = 2e-64
 Identities = 140/396 (35%), Positives = 188/396 (47%), Gaps = 14/396 (3%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GSY C C  G+ L+ + + C   + C +  H C    CVN+ G + C C  GY  
Sbjct: 1129 CHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHS 1188

Query: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
              D   CV +D C+  N GCE  C N++GSY C C  GFAL PD+++CT ID C  + + 
Sbjct: 1189 TPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNI 1248

Query: 372  CQ-HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRCH 429
            C   +C N    Y C C  GF  + D KTC  +N C LN   C    C N + S+ C C 
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCD 1308

Query: 430  RGYTLDPNGKT-CSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
             GY+    GKT C+ ++ C    H C    +C NT  SF C CS G+ I + +K C+ +D
Sbjct: 1309 MGYS-GKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW-IGDGIK-CTDLD 1365

Query: 487  YCLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSS 543
             C    H C     C N   S+ C C EG+    DG TC  LD C+   + C +  C+++
Sbjct: 1366 ECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSENLNLCGNGQCLNA 1423

Query: 544  EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK 603
               + C+C  G++   DGK C   D C   +      C N    + CEC  G+ L   G 
Sbjct: 1424 PGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGG 1483

Query: 604  RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVL 639
             C   + C          CVN   SYIC C   F L
Sbjct: 1484 NCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL 1519



 Score =  240 bits (612), Expect = 5e-63
 Identities = 137/441 (31%), Positives = 204/441 (46%), Gaps = 44/441 (9%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVPGSFVCQC 305
            CA  C+N  GSY C+C  GY+L  D+  C+ +D C    H+C +    C N+ G+++C C
Sbjct: 2217 CAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCIC 2276

Query: 306  YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC--TKI 362
              GY    DG+ CV  + C ++   CE+  C+N  GSY C+C++GF  +P++  C   + 
Sbjct: 2277 GPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNRE 2336

Query: 363  DYCASS--NHGCQHECVNTDD--SYSCHCLKGFTLNPD------------KKTCRR---- 402
             YC +    + CQ    N +      C C  G    P             KK C      
Sbjct: 2337 GYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGF 2396

Query: 403  ------INYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE 455
                  I+ C +    C + ECVN   SY+C C  GYT D  G +C  ++ C Q    C 
Sbjct: 2397 MTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCN 2456

Query: 456  QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG-- 513
             +C NTE S+ C C +G+++ ED ++C  +D C    H C++ CVN    F C+CP G  
Sbjct: 2457 FICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2516

Query: 514  --HVLRSDGKTC-AKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
              H    D   C + ++ C     G +  C ++  SF C+C  G+ L + G +C   D C
Sbjct: 2517 QHHTSCIDNNECTSDINLC-----GSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDEC 2571

Query: 571  QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
            +  +H C+H C N    Y C C +G+       +C  ++ C S H      C N   SY 
Sbjct: 2572 EG-NHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYK 2630

Query: 631  CKCSEGFVLAEDGRRCKKCTE 651
            C C  GF   +    C+   E
Sbjct: 2631 CMCPAGFQYEQFSGGCQDINE 2651



 Score =  214 bits (546), Expect = 2e-55
 Identities = 143/445 (32%), Positives = 200/445 (44%), Gaps = 53/445 (11%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            CIN  GSY C CK GY   S    C  ++ C    + C    C++  GSF C C++G+  
Sbjct: 1824 CINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882

Query: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
             +D   C+ ++ C  +  G    C N  GS+ C+C+ GF L+ +   C  +D CAS N  
Sbjct: 1883 NDDQTMCLDINECERDACG-NGTCRNTIGSFNCRCNHGFILSHNND-CIDVDECASGNGN 1940

Query: 372  -CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRC 428
             C++ +C+NT  S+ C C +G+ + PD +TC  IN C L    C    C N++ SY C C
Sbjct: 1941 LCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCIC 2000

Query: 429  HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS--RV 485
              GY+L    + C  +D C ++   C    C NTE SF C C EGF ++   + C   R+
Sbjct: 2001 PPGYSLQ--NEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRM 2058

Query: 486  DYCLLSDHG----------------------------CEYSCVNMDRSFACQCPEGH-VL 516
             YC     G                            CE      D +F   CP G  ++
Sbjct: 2059 SYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGII 2118

Query: 517  RSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
                 +   +D C   D  C+H  C++++ S+ C+C  GYIL   G  C   D C   + 
Sbjct: 2119 VGPDDSAVDMDECKEPDV-CKHGQCINTDGSYRCECPFGYILA--GNECVDTDECSVGNP 2175

Query: 576  GCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDV--CKSTHHGCEHICVNNGNSYICKC 633
                 C N    + C C EGF   E G     +D+  C      C   CVN   SY CKC
Sbjct: 2176 CGNGTCKNVIGGFECTCEEGF---EPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKC 2232

Query: 634  SEGFVLAEDGRRCK---KCTEGPID 655
              G+VL ED R CK   +C EG  D
Sbjct: 2233 PVGYVLREDRRMCKDEDECEEGKHD 2257



 Score =  214 bits (546), Expect = 2e-55
 Identities = 144/498 (28%), Positives = 218/498 (43%), Gaps = 100/498 (20%)

Query: 242  CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
            C  + + C+H  CI+  GS+ C C  G+  N DQT C   D+   E   C    C N  G
Sbjct: 1853 CQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCL--DINECERDACGNGTCRNTIG 1910

Query: 300  SFVCQCYSGYALAEDGKRCVAVDYCASENHG-CEH-ECVNADGSYLCQCHEGFALNPDKK 357
            SF C+C  G+ L+ +   C+ VD CAS N   C + +C+N  GS+ CQC+EG+ + PD +
Sbjct: 1911 SFNCRCNHGFILSHNND-CIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969

Query: 358  TCTKIDYCASSNHGC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-H 415
            TC  I+ C      C    C N D SY C C  G++L  +K  C  I+ C      C   
Sbjct: 1970 TCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALG 2027

Query: 416  ECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDHG-------------------- 453
             C N E S+ C C  G++L  +G+ C   R+ +C  +  G                    
Sbjct: 2028 TCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCAL 2087

Query: 454  --------CEQLCLNTEDSF--VCQCSEGFLINE-----DLKTCSRVDYCLLSDHGCEYS 498
                    CE      +++F  +C    G ++       D+  C   D C    HG    
Sbjct: 2088 KGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVC---KHG---Q 2141

Query: 499  CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGD---HG-------------------- 535
            C+N D S+ C+CP G++L   G  C   D C++G+   +G                    
Sbjct: 2142 CINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPG 2199

Query: 536  -----------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC- 577
                             C   CV++  S+ C+C  GY+LRED + C+ +D C+   H C 
Sbjct: 2200 PMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCT 2259

Query: 578  --EHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCS 634
              +  C N   +Y C C  G++   DG+ C  ++ C++    CE+  C+N   SY C+C+
Sbjct: 2260 EKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECN 2319

Query: 635  EGFVLAEDGRRCKKCTEG 652
            +GF  + +   C    EG
Sbjct: 2320 DGFTASPNQDECLDNREG 2337



 Score =  199 bits (506), Expect = 1e-50
 Identities = 130/455 (28%), Positives = 188/455 (41%), Gaps = 49/455 (10%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300
            CS +   C  FC N  GSY C C+ G+ L  DQ +C   D C    + C+   C N+PG 
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGE 1260

Query: 301  FVCQCYSGYALAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTC 359
            + C CY G+  +ED K CV V+ C    + C    C N  GS++C C  G++    K  C
Sbjct: 1261 YRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGC 1320

Query: 360  TKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-- 415
            T I+ C    H C     C NT  S+ C C  G+    D   C  ++ C+     C    
Sbjct: 1321 TDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHA 1378

Query: 416  ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFL 474
            +C N   SY C C  GYT D  G TC+ +D C++  + C    CLN    + C+C  GF+
Sbjct: 1379 DCKNTMGSYRCLCKEGYTGD--GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFV 1436

Query: 475  INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
             + D K C  +D C L +     +C N+   F C+C  G+ L   G  C  ++ C     
Sbjct: 1437 PSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTT 1496

Query: 535  GCEHSCVSSEDSFVCQCFEGYILR----------------------EDGKTCRRKDVCQA 572
                +CV++  S++C C   + L                       ++G T    ++   
Sbjct: 1497 CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVG 1556

Query: 573  IDHG-------------CEHICVNSDDSYTCECL--EGFRLAEDGKRCRRKDVCKSTHHG 617
            +                CE     +   Y   C   EGFR           D C+     
Sbjct: 1557 VSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGL 1616

Query: 618  CE-HICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
            C+   C+N   S+ C+C  G+ L ED R C    E
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651



 Score =  184 bits (468), Expect = 3e-46
 Identities = 132/476 (27%), Positives = 194/476 (40%), Gaps = 66/476 (13%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTC--RIQDLC--AMEDHNCE----------QLCVNVP 298
            C N PGS++C C     L+  +T C   I+  C   + D  CE          Q C ++ 
Sbjct: 821  CKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLG 880

Query: 299  GSF-----VCQ----CYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQCHE 348
             ++     +CQ    C  GY+  + G +C  +D C      C++  CVN  GS+ CQC  
Sbjct: 881  AAWGSPCTLCQVDPICGKGYSRIK-GTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPS 939

Query: 349  GFALNPDKKTCTKI------------------------DYCASS------NHGCQHECVN 378
            G  L+   + C  I                        D C  S         C+   + 
Sbjct: 940  GMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMR 999

Query: 379  TDDSYSCHCLKG-----FTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGY 432
                Y   C +G       +   K   + IN C +    C H +C N   S+ CRC  G+
Sbjct: 1000 NTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGF 1059

Query: 433  TLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLIN-EDLKTCSRVDYCLL 490
             LD   + C+ +D C      C +  C+NT   F C+C EG+      +K C  +D C  
Sbjct: 1060 ALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQR 1119

Query: 491  SDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFV 548
                C    C N + S+ C+CP GH L  +   C  ++ C L  H C +  CV+    + 
Sbjct: 1120 DPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQ 1179

Query: 549  CQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRK 608
            C C  GY    D   C   D C  ++ GCE  C NS+ SY C C  GF L  D + C   
Sbjct: 1180 CACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239

Query: 609  DVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGS 663
            D C+   + C+   C N    Y C C +GF+ +ED + C    E  ++    + G+
Sbjct: 1240 DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGT 1295



 Score =  184 bits (466), Expect = 4e-46
 Identities = 128/464 (27%), Positives = 190/464 (40%), Gaps = 54/464 (11%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
            C N  GS++C C  GY     +T C   + C +  HNC +  +C N  GSF C C  G+ 
Sbjct: 1296 CENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI 1355

Query: 311  LAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
               DG +C  +D C++  H C    +C N  GSY C C EG+    D  TCT +D C+ +
Sbjct: 1356 --GDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSEN 1411

Query: 369  NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427
             + C + +C+N    Y C C  GF  + D K C  I+ C+L        C N+   + C 
Sbjct: 1412 LNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCE 1471

Query: 428  CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485
            C  GY LD +G  C+ V+ C          C+NT  S++C C   F +N     C  +R 
Sbjct: 1472 CEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRS 1531

Query: 486  DYCLL-----SDHG----------------------------CEYSCVNMDRSFACQCPE 512
              C L      D+G                            CE         +   CP 
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPG 1591

Query: 513  GHVLRSDGKT--CAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569
            G   R +  T     +D C      C+   C+++  SF C+C  GY L ED + C   + 
Sbjct: 1592 GEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651

Query: 570  CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG----CEHICV 623
            C+         C N+  +YTC C   +     G  C   R+ +C   ++     C+   +
Sbjct: 1652 CETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELL 1711

Query: 624  NNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLG 667
             N    +C CS     A + + C++C     D    + GS+  G
Sbjct: 1712 FNMTKKMCCCSYNIGRAWN-KPCEQCPIPSTDEFATLCGSQRPG 1754



 Score =  182 bits (462), Expect = 1e-45
 Identities = 135/435 (31%), Positives = 190/435 (43%), Gaps = 66/435 (15%)

Query: 290  CEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQC 346
            CE  +C+N+ GSF C+C  G+   +    C  +D C +    C+   EC+N  GSY C C
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN-GPVCQRNAECINTAGSYRCDC 1835

Query: 347  HEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINY 405
              G+      + C   + C    + C H +C++T  S+ C C  GF  N D+  C  IN 
Sbjct: 1836 KPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINE 1894

Query: 406  CALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG-CEQ-LCLNTED 463
            C  +  G    C N   S+ CRC+ G+ L  N   C  VD CA  +   C    C+NT  
Sbjct: 1895 CERDACG-NGTCRNTIGSFNCRCNHGFILSHN-NDCIDVDECASGNGNLCRNGQCINTVG 1952

Query: 464  SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKT 522
            SF CQC+EG+ +  D +TC  ++ CLL    C   +C N+D S+ C CP G+ L+++   
Sbjct: 1953 SFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE--K 2010

Query: 523  CAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCR--RKDVCQAIDHG--- 576
            C  +D C      C   +C ++E SF C C EG+ L   G+ C+  R   C A   G   
Sbjct: 2011 CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKC 2070

Query: 577  -------------------------CEHICVNSDDSYTCECLEGFRL-------AEDGKR 604
                                     CE      D+++   C  G  +       A D   
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 605  CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE-------GPIDLV 657
            C+  DVCK   HG    C+N   SY C+C  G++LA  G  C    E       G     
Sbjct: 2131 CKEPDVCK---HG---QCINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCK 2182

Query: 658  FVIDGSKSLGEENFE 672
             VI G +   EE FE
Sbjct: 2183 NVIGGFECTCEEGFE 2197



 Score =  177 bits (450), Expect = 3e-44
 Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 15/300 (5%)

Query: 261  VCRCKQGYILN-SDQTTCR-IQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
            +C   +G++ N +D   C+ I D+C   +      CVN  GS+ C C +GY     G  C
Sbjct: 2389 LCPHGRGFMTNGADIDECKVIHDVCRNGE------CVNDRGSYHCICKTGYTPDITGTSC 2442

Query: 319  VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
            V ++ C      C   C N +GSY C C +G+ L  D ++C  +D CA+  H CQ  CVN
Sbjct: 2443 VDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVN 2502

Query: 379  TDDSYSCHCLKGFTLNPDKKTCRRINYCA--LNKPGCEHECVNMEESYYCRCHRGYTLDP 436
            T   ++C C  GFT +    +C   N C   +N  G +  C N   S+ C C RG++LD 
Sbjct: 2503 TIGGFTCKCPPGFTQH--HTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQ 2560

Query: 437  NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
             G +C  VD C + +H C+  C N    + C C +G+L +     C   + CL S H C 
Sbjct: 2561 TGSSCEDVDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECL-SAHICG 2618

Query: 497  -YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGY 555
              SC N   S+ C CP G         C  ++ C      C + C ++E  ++C C  GY
Sbjct: 2619 GASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678



 Score =  176 bits (445), Expect = 1e-43
 Identities = 116/384 (30%), Positives = 167/384 (43%), Gaps = 37/384 (9%)

Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPG 299
           C  + + C +  CI  PGS  C C +G+ L+  +  C   D C  E + C    C+N  G
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDL-RGECIDVDEC--EKNPCAGGECINNQG 509

Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKT 358
           S+ CQC +GY        C  +D C      C +  C+N DGS+ C C+ GF +  D K 
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN 569

Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
           C  +D C+  N      C+N D S+ C C  GF L  D + C+ IN C          CV
Sbjct: 570 CEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCV 629

Query: 419 NMEESYYCRCHRGYTLDPNGKTC------------SRVDHCAQQDHGC----EQLCLNTE 462
           N + SY C C  G  +  +G+ C             +   C +   G     E  C +TE
Sbjct: 630 NTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTE 689

Query: 463 DSF--VCQCSEGFLINEDLKTCSR----------VDYCLLSDHGCEYS-CVNMDRSFACQ 509
            +F   CQ        E    CS           ++ C L    C    C N+  ++ C 
Sbjct: 690 YAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCI 749

Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
           C  G+ + S GK C  ++ C L    C++  C ++  SFVC C +G+I + D KTC   D
Sbjct: 750 CNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDID 809

Query: 569 VCQAIDHGCEHICVNSDDSYTCEC 592
            C++       +C NS  S+ CEC
Sbjct: 810 ECES-SPCINGVCKNSPGSFICEC 832



 Score =  172 bits (436), Expect = 1e-42
 Identities = 114/406 (28%), Positives = 177/406 (43%), Gaps = 35/406 (8%)

Query: 279 IQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVN 337
           + D C +  + C+   C+  PGS  C+C  G+ L   G+ C+ VD C  +N     EC+N
Sbjct: 449 VTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGE-CIDVDEC-EKNPCAGGECIN 506

Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPD 396
             GSY CQC  G+     +  C  ID C  +   C +  C+NTD S+ C C  GF +  D
Sbjct: 507 NQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRD 566

Query: 397 KKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456
            K C  ++ C++        C+N + S+ C C  G+ L  +G+ C  ++ C         
Sbjct: 567 GKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNG 626

Query: 457 LCLNTEDSFVCQCSEGFLINEDLKTC------------SRVDYCLLSDHGC----EYSCV 500
            C+NT+ S+ C+C  G  +  D + C             +   C+    G     E  C 
Sbjct: 627 RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCA 686

Query: 501 NMDRSFA--CQ-CP-----EGHVLRSDG----KTCAKLDSCALGDHGCEHS-CVSSEDSF 547
           + + +F   CQ CP     E   L S G       + ++ CAL    C +  C +   ++
Sbjct: 687 STEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTY 746

Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR 606
            C C  GY +   GK C   + C      C++  C N+  S+ C C +GF    D K C 
Sbjct: 747 KCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCE 806

Query: 607 RKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
             D C+S+      +C N+  S+IC+CS    L      C +  +G
Sbjct: 807 DIDECESS-PCINGVCKNSPGSFICECSSESTLDPTKTICIETIKG 851



 Score =  157 bits (398), Expect = 3e-38
 Identities = 117/442 (26%), Positives = 170/442 (38%), Gaps = 65/442 (14%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C+N PG Y C C  G++ ++D   C   D C++ +      C N+PG F C+C  GY L 
Sbjct: 1420 CLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELD 1479

Query: 313  EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC 372
              G  C  V+ C          CVN  GSY+C C   F LNP +  C       + +  C
Sbjct: 1480 RSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVD-----TRSGNC 1534

Query: 373  QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCEH-ECVNMEESYYCRC 428
              +     D+    C     +   K +C     C+L K     CE    VN  E Y   C
Sbjct: 1535 YLDIRPRGDNGDTACSNEIGVGVSKASC----CCSLGKAWGTPCEMCPAVNTSE-YKILC 1589

Query: 429  HRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
              G    PN  T     +D C +    C+   C+NT  SF C+C  G+ +NED + C  V
Sbjct: 1590 PGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDV 1649

Query: 486  DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC---------------------- 523
            + C         +C N   ++ C CP  ++  + G  C                      
Sbjct: 1650 NECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGE 1709

Query: 524  ------AKLDSCALG-----DHGCEHSCVSSEDSFVCQCFE---GYILREDGKTCRRKDV 569
                   K+  C+       +  CE   + S D F   C     G+++          D 
Sbjct: 1710 LLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDE 1769

Query: 570  CQAIDHGCEH-ICVNSDDSYTCECLEGF------RLAEDGKRCRRKDVCKSTHHGCEHIC 622
            C+ I   CE+ +C+N   S+ CEC  GF       + ED   C+   VC+         C
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE-----C 1824

Query: 623  VNNGNSYICKCSEGFVLAEDGR 644
            +N   SY C C  G+     G+
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTGQ 1846



 Score =  156 bits (394), Expect = 1e-37
 Identities = 77/234 (32%), Positives = 107/234 (45%), Gaps = 5/234 (2%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
            C+     C   C N  GSY C C +GYIL  D  +C+  D CA + HNC+ LCVN  G F
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGF 2507

Query: 302  VCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPDKKTC 359
             C+C  G+   +    C+  + C S+ + C  +  C N  GS+ C+C  GF+L+    +C
Sbjct: 2508 TCKCPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSC 2565

Query: 360  TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
              +D C   NH CQH C N    Y C C +G+  +     C   N C          C N
Sbjct: 2566 EDVDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHN 2624

Query: 420  MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
               SY C C  G+  +     C  ++ C      C   C NTE  ++C C  G+
Sbjct: 2625 TLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 52/171 (30%), Positives = 76/171 (44%), Gaps = 11/171 (6%)

Query: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
           V  K LC    C+T+     H C   P      C++G+I N     C+  D C      C
Sbjct: 203 VCTKTLC----CATVGRAWGHPCEMCPAQ-PHPCRRGFIPNIRTGACQDVDECQAIPGLC 257

Query: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348
           +   C+N  GSF C+C +G+ L E  ++C  +D C++    CE  EC N   SY C+C  
Sbjct: 258 QGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPP 317

Query: 349 GFALNPDKKTCTKID----YCASSNHGCQHECVNTDDSYSCHCLKGFTLNP 395
           GF  +PD   C  +     Y A +N  C ++   +     C C  G   +P
Sbjct: 318 GFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSP 368



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 77/279 (27%), Positives = 101/279 (36%), Gaps = 58/279 (20%)

Query: 387 CLKGFTLNPDKKTC-----------RRINYC---ALNKPGCEHECVNMEESYYCRCHRGY 432
           C  GF   P+  TC           R I +C    +N   C  +        +C C +GY
Sbjct: 89  CGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD--------HCLCQKGY 140

Query: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFV---CQCSEGFLINEDLKTCSRVDYCL 489
                        HC Q    CE  CLN         C C+ GF   +    C R DY  
Sbjct: 141 I----------GTHCGQPV--CESGCLNGGRCVAPNRCACTYGFTGPQ----CER-DYRT 183

Query: 490 LSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVC 549
                    C  +  +  CQ       +  G  C K   CA       H C         
Sbjct: 184 -------GPCFTVISNQMCQG------QLSGIVCTKTLCCATVGRAWGHPCEMCPAQ-PH 229

Query: 550 QCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK 608
            C  G+I       C+  D CQAI   C+   C+N+  S+ C+C  G +L E  ++C   
Sbjct: 230 PCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDI 289

Query: 609 DVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646
           D C +    CE   C N  +SY CKC  GF  + DG RC
Sbjct: 290 DECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 72/304 (23%), Positives = 104/304 (34%), Gaps = 67/304 (22%)

Query: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354
           NV GS +   C  G+     G +C+           C H C            +GF   P
Sbjct: 57  NVCGSRYNAYCCPGWKTLPGGNQCIVPI--------CRHSC-----------GDGFCSRP 97

Query: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPG 412
           +  TC       S        C       +  C+ G + + D   C++  Y   +  +P 
Sbjct: 98  NMCTCPSGQIAPSCGSRSIQHC-------NIRCMNGGSCSDDHCLCQK-GYIGTHCGQPV 149

Query: 413 CEHECVN-----MEESYYC-------RCHRGYTLDP--------------NGKTCSRVDH 446
           CE  C+N           C       +C R Y   P              +G  C++   
Sbjct: 150 CESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLC 209

Query: 447 CAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVN 501
           CA       H CE             C  GF+ N     C  VD C      C+  +C+N
Sbjct: 210 CATVGRAWGHPCEMCPAQPHP-----CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCIN 264

Query: 502 MDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILRED 560
              SF C+CP GH L    + C  +D C+     CE   C ++  S+ C+C  G+    D
Sbjct: 265 TVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPD 324

Query: 561 GKTC 564
           G  C
Sbjct: 325 GTRC 328



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 64/281 (22%), Positives = 97/281 (34%), Gaps = 64/281 (22%)

Query: 383 YSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 442
           Y+ +C  G+      KT    N C +  P C H C +           G+   PN  TC 
Sbjct: 63  YNAYCCPGW------KTLPGGNQCIV--PICRHSCGD-----------GFCSRPNMCTCP 103

Query: 443 R---VDHCAQQD-HGCEQLCLN----TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHG 494
                  C  +    C   C+N    ++D   C C +G++            +C      
Sbjct: 104 SGQIAPSCGSRSIQHCNIRCMNGGSCSDDH--CLCQKGYIGT----------HC--GQPV 149

Query: 495 CEYSCVNMDRSFA---CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
           CE  C+N  R  A   C C  G      G  C +       D+     C +   + +CQ 
Sbjct: 150 CESGCLNGGRCVAPNRCACTYGFT----GPQCER-------DYRTG-PCFTVISNQMCQ- 196

Query: 552 FEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC 611
             G +    G  C +   C  +     H C     +    C  GF        C+  D C
Sbjct: 197 --GQL---SGIVCTKTLCCATVGRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDEC 250

Query: 612 KSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
           ++    C+   C+N   S+ CKC  G  L E  ++C+   E
Sbjct: 251 QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDE 291


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  238 bits (607), Expect = 2e-62
 Identities = 144/446 (32%), Positives = 212/446 (47%), Gaps = 36/446 (8%)

Query: 223  SQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ 280
            SQ+   T V +   CT +  +C       A  CIN+P  Y C C +GY  +  Q  C   
Sbjct: 864  SQVIAPTQVTEINECTVNPDICG------AGHCINLPVRYTCICYEGYRFSEQQRKCVDI 917

Query: 281  DLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNAD 339
            D C    H C Q  C N  GSF+C C +G+  +E+G  C+ VD C   +   E  CVN  
Sbjct: 918  DECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTV 977

Query: 340  GSYLCQ-CHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC-HCLKGF------ 391
            G++ C+ C  G+ +   +  C  ID C + +     +CVN+  SY C  C +GF      
Sbjct: 978  GAFRCEYCDSGYRMT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 1036

Query: 392  TLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
             L+ D+  C   N CA        +C N+E SY C CH+GYT  P+ K C  +D C Q +
Sbjct: 1037 CLDVDE--CLEPNVCA------NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 1088

Query: 452  HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL---LSDHGCEYSCVNMDRSFAC 508
                  C NTE SF C C +G+ ++     C  +D C    L  HG    C N + SF C
Sbjct: 1089 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHG---QCRNTEGSFQC 1145

Query: 509  QCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRK 567
             C +G+     G  C  ++ C      C+   C+++  S+ C C +G+ L +D KTC+  
Sbjct: 1146 VCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDI 1204

Query: 568  DVCQAID-HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNN 625
            + C+     G +  C+N++ S+ C C +GF ++ DG+ C   D C  +T       C N 
Sbjct: 1205 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNT 1264

Query: 626  GNSYICKCSEGFVLAEDGRRCKKCTE 651
              S+ C C +GF   +DG+ C    E
Sbjct: 1265 AGSFRCLCYQGFQAPQDGQGCVDVNE 1290



 Score =  237 bits (605), Expect = 3e-62
 Identities = 137/413 (33%), Positives = 199/413 (48%), Gaps = 17/413 (4%)

Query: 233  QKKLCTAHMCSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE 291
            Q+K      C+ ++H C+   C N  GS++C C  G++ + + T C   D C   D   E
Sbjct: 911  QRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGE 970

Query: 292  QLCVNVPGSFVCQ-CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEG 349
              CVN  G+F C+ C SGY + + G RC  +D C + +   + +CVN+ GSY C  C EG
Sbjct: 971  GHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEG 1029

Query: 350  FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
            F        C  +D C   N     +C N + SY C C KG+T  PD K CR I+ C   
Sbjct: 1030 F--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG 1087

Query: 410  KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
                  +C N E S+ C C +GY L      C  +D C  +       C NTE SF C C
Sbjct: 1088 NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVC 1147

Query: 470  SEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
             +G+  +     C  ++ CL     C+   C+N   S+ C CP+G  L  D KTC  ++ 
Sbjct: 1148 DQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINE 1206

Query: 529  CAL-GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ----AIDHGCEHICVN 583
            C   G  G +  C+++E SF C C +G+ +  DG+TC   D C        HG    C N
Sbjct: 1207 CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDN 1263

Query: 584  SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCSE 635
            +  S+ C C +GF+  +DG+ C   + C+     C E  C N   S++C C++
Sbjct: 1264 TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 1316



 Score =  190 bits (482), Expect = 6e-48
 Identities = 133/466 (28%), Positives = 193/466 (41%), Gaps = 74/466 (15%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C N+ GSY+C C +GY    D   CR  D C   +      C N  GSF C C  GY L+
Sbjct: 1054 CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1113

Query: 313  EDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
                +C  +D C    H C H +C N +GS+ C C +G+  +     C  I+ C      
Sbjct: 1114 AAKDQCEDIDEC-QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 1172

Query: 372  CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCR 427
            CQ  +C+NT  SY C C  GF L+ D KTC+ IN C    PG    + EC+N E S++C 
Sbjct: 1173 CQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINEC--EHPGLCGPQGECLNTEGSFHCV 1229

Query: 428  CHRGYTLDPNGKTCSRVDHCAQQ----DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
            C +G+++  +G+TC  +D C        HG    C NT  SF C C +GF   +D + C 
Sbjct: 1230 CQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDNTAGSFRCLCYQGFQAPQDGQGCV 1286

Query: 484  RVDYCLLSDHGC-EYSCVNMDRSFACQCP------------------------------- 511
             V+ C L    C E  C N++ SF C C                                
Sbjct: 1287 DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346

Query: 512  --EGHVLRSDGKTC--------AKLDSCALGDHGCEHSCV--------SSEDSFVCQCFE 553
              E +   +D   C         K + C     G   +C         ++E + +C   +
Sbjct: 1347 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1406

Query: 554  GYILRED------GKTCRRKDVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
            G++   +      G+  +  D C       C++  C+N+   Y C C +G        +C
Sbjct: 1407 GFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC 1466

Query: 606  RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
               D C+      +  CVN   SY C C+   VL    +RC +  E
Sbjct: 1467 FDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1512



 Score =  120 bits (300), Expect = 8e-27
 Identities = 121/496 (24%), Positives = 183/496 (36%), Gaps = 110/496 (22%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
            C+N  GS+ C C+QG+ +++D  TC   D C + +  C+    C N  GSF C CY G+ 
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1277

Query: 311  LAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQC-HEGFALNP-------------- 354
              +DG+ CV V+ C   +  C E  C N +GS+LC C  E    +P              
Sbjct: 1278 APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1337

Query: 355  --------DKKTC------------------TKIDYCASSNHGCQHEC------VNTDDS 382
                    +KK C                  TK + C +S  G    C      V     
Sbjct: 1338 VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1397

Query: 383  YSCHCLKGFTLNPDKKTCRRI---NY-----CAL-NKPGCEHE-CVNMEESYYCRCHRGY 432
            ++  C KG    P  ++       NY     C L  +  C++  C+N    Y C C +G 
Sbjct: 1398 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGT 1457

Query: 433  TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-------- 484
              DP    C  +D C       +  C+NTE S+ C C+   +++   K C R        
Sbjct: 1458 YYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1517

Query: 485  ------VDYC---LLSDHGCEYSCVNMDRSFA-CQCPEGHVLRSDGKTCAKLDS------ 528
                   D C   L  ++ C    V    ++  C C  G         C   DS      
Sbjct: 1518 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQL 1577

Query: 529  CALGDHG-------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
            C +   G              E     ++  F+   F         + C        I +
Sbjct: 1578 CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEEC-------GILN 1630

Query: 576  GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNNGNSYI 630
            GCE+  CV   + YTC+C +G+ L      C   + C   ++    C++  C+N   SY 
Sbjct: 1631 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1690

Query: 631  CKCSEGFVLAEDGRRC 646
            C C  G+V ++    C
Sbjct: 1691 CLCLPGYVPSDKPNYC 1706



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 71/277 (25%), Positives = 104/277 (37%), Gaps = 43/277 (15%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
            FC+N    Y C CKQG   +  +  C   D C       +  CVN  GS+ C C     L
Sbjct: 1441 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1500

Query: 312  AEDGKRCVAV--------------DYC---ASENHGCEHECVNADGSYL-CQCHEGFALN 353
                KRC+                D C    S+ + C    V    +Y  C C  G A  
Sbjct: 1501 DASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWG 1560

Query: 354  PDKKTCTKIDYCASSNHG--CQHECVNTDDSYSCHCLKGFT------LNPDKKTCRRINY 405
                 C   D   S ++   C          Y    L  F+       +P     R +N 
Sbjct: 1561 MQCALCPLKD---SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNS 1617

Query: 406  --------CALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG--- 453
                    C +   GCE+  CV ++E Y C C  GY LD    TC  V+ C + ++    
Sbjct: 1618 FEELQAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSL 1676

Query: 454  CEQL-CLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL 489
            C+   C+NT+ S+ C C  G++ ++    C+ ++  L
Sbjct: 1677 CKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 61/271 (22%), Positives = 99/271 (36%), Gaps = 37/271 (13%)

Query: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
            C+N    + C C  G        +C  +D C   +   + +CVN +GSY C C     L+
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD 1501

Query: 354  PDKKTCTKI--------------DYC---ASSNHGCQHECVNTDDSYS-CHCLKG----- 390
              +K C +               D C    S  + C    V    +Y+ C CL G     
Sbjct: 1502 ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1561

Query: 391  -FTLNPDKKTCRRINYCAL-----NKPGCEHECVNMEESYYCRCHRGYTLDP--NGKTCS 442
               L P K +      C +      +P      V+  E Y       +  D   N     
Sbjct: 1562 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1621

Query: 443  RVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY---- 497
            + + C   + GCE   C+  ++ + C C +G+ ++    TC  V+ C   ++        
Sbjct: 1622 QAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1680

Query: 498  SCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
             C+N D S+ C C  G+V       C  L++
Sbjct: 1681 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNT 1711



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 59/211 (27%), Positives = 89/211 (42%), Gaps = 37/211 (17%)

Query: 224  QIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYV-CRCKQGYILNSDQTTCRIQDL 282
            QIE  T V+Q  LC  H+    E+ C+   +    +Y  C C  G         C ++D 
Sbjct: 1516 QIEE-TDVYQD-LCWEHLSD--EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD- 1570

Query: 283  CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------VAVDY 323
                  +  QLC N+P +   Q Y   AL +  ++                    +  + 
Sbjct: 1571 ----SDDYAQLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEE 1625

Query: 324  CASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVN 378
            C   N GCE+  CV     Y C C +G+ L+  K TC  ++ C   N+    C++ +C+N
Sbjct: 1626 CGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684

Query: 379  TDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
            TD SY C CL G+  +     C  +N  ALN
Sbjct: 1685 TDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1714



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 12/114 (10%)

Query: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
           +C  GY    +   C  ++ C  +      EC+N  GSY C C  GF  +P   +C    
Sbjct: 611 ECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 669

Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCE 414
              S   G  +  V    S    C+   +++  K+ C     C++ K   P CE
Sbjct: 670 PVISEEKGPCYRLV----SSGRQCMHPLSVHLTKQLC----CCSVGKAWGPHCE 715



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)

Query: 387 CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
           CL G+    +   C+ IN C L       EC+N   SY C C  G+  DP   +C
Sbjct: 612 CLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 25/98 (25%), Positives = 33/98 (33%), Gaps = 17/98 (17%)

Query: 273 DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG-- 330
           D   C++Q +C   +      C+N  GS+ C C  G+        CV      SE  G  
Sbjct: 626 DINECQLQGVCPNGE------CLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679

Query: 331 ---------CEHECVNADGSYLCQCHEGFALNPDKKTC 359
                    C H         LC C  G A  P  + C
Sbjct: 680 YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC 717



 Score = 30.4 bits (67), Expect = 8.1
 Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 7/121 (5%)

Query: 437 NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
           N   C  ++ C  Q       CLNT  S+ C C  GF  +    +C      +  + G  
Sbjct: 620 NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679

Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEG 554
           Y  V+  R    QC     +    + C      A G H CE   +    +F  +C    G
Sbjct: 680 YRLVSSGR----QCMHPLSVHLTKQLCCCSVGKAWGPH-CEKCPLPGTAAFKEICPGGMG 734

Query: 555 Y 555
           Y
Sbjct: 735 Y 735


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  238 bits (607), Expect = 2e-62
 Identities = 144/446 (32%), Positives = 212/446 (47%), Gaps = 36/446 (8%)

Query: 223 SQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ 280
           SQ+   T V +   CT +  +C       A  CIN+P  Y C C +GY  +  Q  C   
Sbjct: 538 SQVIAPTQVTEINECTVNPDICG------AGHCINLPVRYTCICYEGYRFSEQQRKCVDI 591

Query: 281 DLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNAD 339
           D C    H C Q  C N  GSF+C C +G+  +E+G  C+ VD C   +   E  CVN  
Sbjct: 592 DECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTV 651

Query: 340 GSYLCQ-CHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC-HCLKGF------ 391
           G++ C+ C  G+ +   +  C  ID C + +     +CVN+  SY C  C +GF      
Sbjct: 652 GAFRCEYCDSGYRMT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 710

Query: 392 TLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
            L+ D+  C   N CA        +C N+E SY C CH+GYT  P+ K C  +D C Q +
Sbjct: 711 CLDVDE--CLEPNVCA------NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 762

Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL---LSDHGCEYSCVNMDRSFAC 508
                 C NTE SF C C +G+ ++     C  +D C    L  HG    C N + SF C
Sbjct: 763 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHG---QCRNTEGSFQC 819

Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRK 567
            C +G+     G  C  ++ C      C+   C+++  S+ C C +G+ L +D KTC+  
Sbjct: 820 VCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDI 878

Query: 568 DVCQAID-HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNN 625
           + C+     G +  C+N++ S+ C C +GF ++ DG+ C   D C  +T       C N 
Sbjct: 879 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNT 938

Query: 626 GNSYICKCSEGFVLAEDGRRCKKCTE 651
             S+ C C +GF   +DG+ C    E
Sbjct: 939 AGSFRCLCYQGFQAPQDGQGCVDVNE 964



 Score =  237 bits (605), Expect = 3e-62
 Identities = 137/413 (33%), Positives = 199/413 (48%), Gaps = 17/413 (4%)

Query: 233 QKKLCTAHMCSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE 291
           Q+K      C+ ++H C+   C N  GS++C C  G++ + + T C   D C   D   E
Sbjct: 585 QRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGE 644

Query: 292 QLCVNVPGSFVCQ-CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEG 349
             CVN  G+F C+ C SGY + + G RC  +D C + +   + +CVN+ GSY C  C EG
Sbjct: 645 GHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEG 703

Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
           F        C  +D C   N     +C N + SY C C KG+T  PD K CR I+ C   
Sbjct: 704 F--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG 761

Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
                 +C N E S+ C C +GY L      C  +D C  +       C NTE SF C C
Sbjct: 762 NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVC 821

Query: 470 SEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
            +G+  +     C  ++ CL     C+   C+N   S+ C CP+G  L  D KTC  ++ 
Sbjct: 822 DQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINE 880

Query: 529 CAL-GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ----AIDHGCEHICVN 583
           C   G  G +  C+++E SF C C +G+ +  DG+TC   D C        HG    C N
Sbjct: 881 CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDN 937

Query: 584 SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCSE 635
           +  S+ C C +GF+  +DG+ C   + C+     C E  C N   S++C C++
Sbjct: 938 TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 990



 Score =  190 bits (482), Expect = 6e-48
 Identities = 133/466 (28%), Positives = 193/466 (41%), Gaps = 74/466 (15%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C N+ GSY+C C +GY    D   CR  D C   +      C N  GSF C C  GY L+
Sbjct: 728  CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 787

Query: 313  EDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
                +C  +D C    H C H +C N +GS+ C C +G+  +     C  I+ C      
Sbjct: 788  AAKDQCEDIDEC-QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 846

Query: 372  CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCR 427
            CQ  +C+NT  SY C C  GF L+ D KTC+ IN C    PG    + EC+N E S++C 
Sbjct: 847  CQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINEC--EHPGLCGPQGECLNTEGSFHCV 903

Query: 428  CHRGYTLDPNGKTCSRVDHCAQQ----DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
            C +G+++  +G+TC  +D C        HG    C NT  SF C C +GF   +D + C 
Sbjct: 904  CQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDNTAGSFRCLCYQGFQAPQDGQGCV 960

Query: 484  RVDYCLLSDHGC-EYSCVNMDRSFACQCP------------------------------- 511
             V+ C L    C E  C N++ SF C C                                
Sbjct: 961  DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020

Query: 512  --EGHVLRSDGKTC--------AKLDSCALGDHGCEHSCV--------SSEDSFVCQCFE 553
              E +   +D   C         K + C     G   +C         ++E + +C   +
Sbjct: 1021 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1080

Query: 554  GYILRED------GKTCRRKDVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
            G++   +      G+  +  D C       C++  C+N+   Y C C +G        +C
Sbjct: 1081 GFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC 1140

Query: 606  RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
               D C+      +  CVN   SY C C+   VL    +RC +  E
Sbjct: 1141 FDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1186



 Score =  120 bits (300), Expect = 8e-27
 Identities = 121/496 (24%), Positives = 183/496 (36%), Gaps = 110/496 (22%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
            C+N  GS+ C C+QG+ +++D  TC   D C + +  C+    C N  GSF C CY G+ 
Sbjct: 893  CLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQ 951

Query: 311  LAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQC-HEGFALNP-------------- 354
              +DG+ CV V+ C   +  C E  C N +GS+LC C  E    +P              
Sbjct: 952  APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1011

Query: 355  --------DKKTC------------------TKIDYCASSNHGCQHEC------VNTDDS 382
                    +KK C                  TK + C +S  G    C      V     
Sbjct: 1012 VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1071

Query: 383  YSCHCLKGFTLNPDKKTCRRI---NY-----CAL-NKPGCEHE-CVNMEESYYCRCHRGY 432
            ++  C KG    P  ++       NY     C L  +  C++  C+N    Y C C +G 
Sbjct: 1072 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGT 1131

Query: 433  TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-------- 484
              DP    C  +D C       +  C+NTE S+ C C+   +++   K C R        
Sbjct: 1132 YYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1191

Query: 485  ------VDYC---LLSDHGCEYSCVNMDRSFA-CQCPEGHVLRSDGKTCAKLDS------ 528
                   D C   L  ++ C    V    ++  C C  G         C   DS      
Sbjct: 1192 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQL 1251

Query: 529  CALGDHG-------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
            C +   G              E     ++  F+   F         + C        I +
Sbjct: 1252 CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEEC-------GILN 1304

Query: 576  GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNNGNSYI 630
            GCE+  CV   + YTC+C +G+ L      C   + C   ++    C++  C+N   SY 
Sbjct: 1305 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1364

Query: 631  CKCSEGFVLAEDGRRC 646
            C C  G+V ++    C
Sbjct: 1365 CLCLPGYVPSDKPNYC 1380



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 71/277 (25%), Positives = 104/277 (37%), Gaps = 43/277 (15%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
            FC+N    Y C CKQG   +  +  C   D C       +  CVN  GS+ C C     L
Sbjct: 1115 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1174

Query: 312  AEDGKRCVAV--------------DYC---ASENHGCEHECVNADGSYL-CQCHEGFALN 353
                KRC+                D C    S+ + C    V    +Y  C C  G A  
Sbjct: 1175 DASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWG 1234

Query: 354  PDKKTCTKIDYCASSNHG--CQHECVNTDDSYSCHCLKGFT------LNPDKKTCRRINY 405
                 C   D   S ++   C          Y    L  F+       +P     R +N 
Sbjct: 1235 MQCALCPLKD---SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNS 1291

Query: 406  --------CALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG--- 453
                    C +   GCE+  CV ++E Y C C  GY LD    TC  V+ C + ++    
Sbjct: 1292 FEELQAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSL 1350

Query: 454  CEQL-CLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL 489
            C+   C+NT+ S+ C C  G++ ++    C+ ++  L
Sbjct: 1351 CKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 61/271 (22%), Positives = 99/271 (36%), Gaps = 37/271 (13%)

Query: 294  CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
            C+N    + C C  G        +C  +D C   +   + +CVN +GSY C C     L+
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD 1175

Query: 354  PDKKTCTKI--------------DYC---ASSNHGCQHECVNTDDSYS-CHCLKG----- 390
              +K C +               D C    S  + C    V    +Y+ C CL G     
Sbjct: 1176 ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1235

Query: 391  -FTLNPDKKTCRRINYCAL-----NKPGCEHECVNMEESYYCRCHRGYTLDP--NGKTCS 442
               L P K +      C +      +P      V+  E Y       +  D   N     
Sbjct: 1236 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1295

Query: 443  RVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY---- 497
            + + C   + GCE   C+  ++ + C C +G+ ++    TC  V+ C   ++        
Sbjct: 1296 QAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1354

Query: 498  SCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
             C+N D S+ C C  G+V       C  L++
Sbjct: 1355 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNT 1385



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 59/211 (27%), Positives = 89/211 (42%), Gaps = 37/211 (17%)

Query: 224  QIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYV-CRCKQGYILNSDQTTCRIQDL 282
            QIE  T V+Q  LC  H+    E+ C+   +    +Y  C C  G         C ++D 
Sbjct: 1190 QIEE-TDVYQD-LCWEHLSD--EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD- 1244

Query: 283  CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------VAVDY 323
                  +  QLC N+P +   Q Y   AL +  ++                    +  + 
Sbjct: 1245 ----SDDYAQLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEE 1299

Query: 324  CASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVN 378
            C   N GCE+  CV     Y C C +G+ L+  K TC  ++ C   N+    C++ +C+N
Sbjct: 1300 CGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358

Query: 379  TDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
            TD SY C CL G+  +     C  +N  ALN
Sbjct: 1359 TDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1388



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 12/114 (10%)

Query: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
           +C  GY    +   C  ++ C  +      EC+N  GSY C C  GF  +P   +C    
Sbjct: 285 ECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 343

Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCE 414
              S   G  +  V    S    C+   +++  K+ C     C++ K   P CE
Sbjct: 344 PVISEEKGPCYRLV----SSGRQCMHPLSVHLTKQLC----CCSVGKAWGPHCE 389



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)

Query: 387 CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
           CL G+    +   C+ IN C L       EC+N   SY C C  G+  DP   +C
Sbjct: 286 CLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 25/98 (25%), Positives = 33/98 (33%), Gaps = 17/98 (17%)

Query: 273 DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG-- 330
           D   C++Q +C   +      C+N  GS+ C C  G+        CV      SE  G  
Sbjct: 300 DINECQLQGVCPNGE------CLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353

Query: 331 ---------CEHECVNADGSYLCQCHEGFALNPDKKTC 359
                    C H         LC C  G A  P  + C
Sbjct: 354 YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC 391



 Score = 30.4 bits (67), Expect = 8.1
 Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 7/121 (5%)

Query: 437 NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
           N   C  ++ C  Q       CLNT  S+ C C  GF  +    +C      +  + G  
Sbjct: 294 NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353

Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEG 554
           Y  V+  R    QC     +    + C      A G H CE   +    +F  +C    G
Sbjct: 354 YRLVSSGR----QCMHPLSVHLTKQLCCCSVGKAWGPH-CEKCPLPGTAAFKEICPGGMG 408

Query: 555 Y 555
           Y
Sbjct: 409 Y 409


>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  231 bits (588), Expect = 3e-60
 Identities = 147/466 (31%), Positives = 201/466 (43%), Gaps = 69/466 (14%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRI----------------------------- 279
            C H CIN  GSY C C  G+ L  D  TCR                              
Sbjct: 616  CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675

Query: 280  ---QDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE-- 334
               Q     ++  C+Q+C  V GS +C C+ GYA+  DG  C   D C    H C     
Sbjct: 676  PLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQF 735

Query: 335  CVNADGSYLC-----QCHEGFALNPDKKTCTKIDYCASSNHGCQ--HECVNTDDSYSCHC 387
            CVN  GS+ C      C +G+ LN  +K C  I+ C +  H C     CVNT  S+  HC
Sbjct: 736  CVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHCVNTLGSF--HC 792

Query: 388  LKGFTLNP----DKKTCRRINYCALNKPGCE--HECVNMEESYYC----RCHRGYTLDPN 437
             K  T  P        C  ++ CA+    C+    C N + S+YC    RC  G+  DP 
Sbjct: 793  YKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE 852

Query: 438  GKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ-----CSEGFLINEDLKTCSRVDYCLL 490
            G  C  ++ C      C     C+NT  S+ CQ     C+ G+  ++D   C  V+ C  
Sbjct: 853  G-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECET 911

Query: 491  SDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSF 547
              H C     C N+  S+ C C  G    + G+ C  ++ C A     C+H+C ++  S+
Sbjct: 912  GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSY 971

Query: 548  VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
             C C  G++L  DGK C   + C+A    C   C N   SY C C +G++LAEDG  C  
Sbjct: 972  RCSCASGFLLAADGKRCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTD 1029

Query: 608  KDVC-KSTHHGCEHICVNNGNSYICKCSE-GFVLAEDGRRCKKCTE 651
             D C +     C   C+N   SY C C E G+ +  +GR CK   E
Sbjct: 1030 IDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1075



 Score =  221 bits (562), Expect = 3e-57
 Identities = 143/438 (32%), Positives = 195/438 (44%), Gaps = 43/438 (9%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVC--- 303
            C   C  + GS +C C  GY + +D  +C  QD C M  H+C   Q CVN  GSF C   
Sbjct: 689  CKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNH 748

Query: 304  --QCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLC----QCHEGFALNPD 355
               C  GY L    ++CV ++ C ++ H C     CVN  GS+ C     C  G+AL   
Sbjct: 749  TVLCADGYIL-NAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG 807

Query: 356  KKTCTKIDYCASSNHGCQ--HECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALN 409
            +  C  +D CA   H CQ    C NT  S+ C     C+ GF  +P+   C  IN C   
Sbjct: 808  E--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE-GNCVDINECTSL 864

Query: 410  KPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLN 460
               C     C+N   SY C+     C RGY    +G  C  V+ C    H C   Q+C N
Sbjct: 865  SEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHN 924

Query: 461  TEDSFVCQCSEGFLINEDLKTCSRVDYCLLS-DHGCEYSCVNMDRSFACQCPEGHVLRSD 519
               S+ C C  GF  +   + C  V+ C  S    C+++C N   S+ C C  G +L +D
Sbjct: 925  LPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAAD 984

Query: 520  GKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC-QAIDHGCE 578
            GK C  ++ C      C   C +   S+ C C +GY L EDG TC   D C Q     C 
Sbjct: 985  GKRCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCT 1042

Query: 579  HICVNSDDSYTCECLE-GFRLAEDGKRCRRKDVCKSTHHGCE--HICVNNGNSYIC---K 632
              C+N   SY C C E G+ +  +G+ C+  D C    H C     C N   S+ C   +
Sbjct: 1043 FRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE 1102

Query: 633  CSEGFVLAEDGRRCKKCT 650
            C   +V      +C++ T
Sbjct: 1103 CPPNYVQVSK-TKCERTT 1119



 Score =  207 bits (526), Expect = 5e-53
 Identities = 136/438 (31%), Positives = 185/438 (42%), Gaps = 71/438 (16%)

Query: 280  QDLCAM-EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------- 318
            QD C +     C+ LC+N  GS+ C C+ G++L +DG+ C                    
Sbjct: 605  QDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSE 664

Query: 319  ------------VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
                        +       +N  C+  C    GS +C C  G+A+  D  +C   D C 
Sbjct: 665  FSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECL 724

Query: 367  SSNHGCQHE--CVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALNKPGCE--HEC 417
               H C     CVNT  S+ C      C  G+ LN  +K C  IN C  +   C     C
Sbjct: 725  MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHC 783

Query: 418  VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ--- 468
            VN   S++C     C  GY L      C  VD CA   H C+   LC NT+ SF CQ   
Sbjct: 784  VNTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ 841

Query: 469  -CSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEGHVLRSDG 520
             C +GFL + +   C  ++ C      C   +SC+N   S+ CQ     C  G+    DG
Sbjct: 842  RCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDG 900

Query: 521  KTCAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI-DHGC 577
              C  ++ C  G H C     C +   S+ C C  G+     G+ C   + C A     C
Sbjct: 901  TKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC 960

Query: 578  EHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGF 637
            +H C N+  SY C C  GF LA DGKRC   + C++    C   C N   SY C C +G+
Sbjct: 961  QHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGY 1018

Query: 638  VLAEDGRRC---KKCTEG 652
             LAEDG  C    +C +G
Sbjct: 1019 QLAEDGHTCTDIDECAQG 1036



 Score =  178 bits (452), Expect = 2e-44
 Identities = 109/315 (34%), Positives = 144/315 (45%), Gaps = 30/315 (9%)

Query: 242  CSTLEHNC--AHFCINIPGSYVC----RCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--L 293
            C+   H C     C N  GS+ C    RC  G++ + +     I + C      C     
Sbjct: 815  CAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINE-CTSLSEPCRPGFS 873

Query: 294  CVNVPGSFVCQ-----CYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQC 346
            C+N  GS+ CQ     C  GY  ++DG +CV V+ C +  H C     C N  GSY C C
Sbjct: 874  CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933

Query: 347  HEGFALNPDKKTCTKIDYC-ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINY 405
              GF  +   + C  ++ C AS    CQH C NT  SY C C  GF L  D K C  +N 
Sbjct: 934  KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNE 993

Query: 406  CALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDS 464
            C   +  C  EC N+  SY C C +GY L  +G TC+ +D CAQ     C   CLN   S
Sbjct: 994  CEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1051

Query: 465  FVCQCSE-GFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFAC---QCPEGHVLRS 518
            + C C E G+ +  + ++C  VD C L  H C    +C N+  SF C   +CP  +V  S
Sbjct: 1052 YQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVS 1111

Query: 519  DGK----TCAKLDSC 529
              K    TC     C
Sbjct: 1112 KTKCERTTCHDFLEC 1126


>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
          Length = 1184

 Score =  219 bits (559), Expect = 7e-57
 Identities = 144/463 (31%), Positives = 196/463 (42%), Gaps = 67/463 (14%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRI----------------------------- 279
            C H CIN  GSY C C  G+ L  D  TCR                              
Sbjct: 616  CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675

Query: 280  ---QDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HE 334
               Q     ++  C+Q+C  V GS +C C+ GYA+  DG  C  ++ C ++ H C     
Sbjct: 676  PLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEH 735

Query: 335  CVNADGSYLC----QCHEGFALNPDKKTCTKIDYCASSNHGCQ--HECVNTDDSYSC--- 385
            CVN  GS+ C     C  G+AL   +  C  +D CA   H CQ    C NT  S+ C   
Sbjct: 736  CVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 793

Query: 386  -HCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPN 437
              C+ GF  +P+   C  IN C      C     C+N   SY C+     C RGY    +
Sbjct: 794  QRCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDD 852

Query: 438  GKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLS-DHG 494
            G  C  V+ C    H C   Q+C N   S+ C C  GF  +   + C  V+ C  S    
Sbjct: 853  GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRL 912

Query: 495  CEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEG 554
            C+++C N   S+ C C  G +L +DGK C  ++ C      C   C +   S+ C C +G
Sbjct: 913  CQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQECANIYGSYQCYCRQG 970

Query: 555  YILREDGKTCRRKDVC-QAIDHGCEHICVNSDDSYTCECLE-GFRLAEDGKRCRRKDVCK 612
            Y L EDG TC   D C Q     C   C+N   SY C C E G+ +  +G+ C+  D C 
Sbjct: 971  YQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECA 1030

Query: 613  STHHGCE--HICVNNGNSYIC---KCSEGFVLAEDGRRCKKCT 650
               H C     C N   S+ C   +C   +V      +C++ T
Sbjct: 1031 LGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSK-TKCERTT 1072



 Score =  204 bits (518), Expect = 4e-52
 Identities = 127/429 (29%), Positives = 185/429 (43%), Gaps = 62/429 (14%)

Query: 280  QDLCAM-EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------- 318
            QD C +     C+ LC+N  GS+ C C+ G++L +DG+ C                    
Sbjct: 605  QDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSE 664

Query: 319  ------------VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
                        +       +N  C+  C    GS +C C  G+A+  D  +C  I+ C 
Sbjct: 665  FSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECV 724

Query: 367  SSNHGCQ--HECVNTDDSYSCHCLKGFTLNP----DKKTCRRINYCALNKPGCE--HECV 418
            +  H C     CVNT  S+  HC K  T  P        C  ++ CA+    C+    C 
Sbjct: 725  TDLHTCSRGEHCVNTLGSF--HCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQ 782

Query: 419  NMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ---- 468
            N + S+YC    RC  G+  DP G  C  ++ C      C     C+NT  S+ CQ    
Sbjct: 783  NTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841

Query: 469  -CSEGFLINEDLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAK 525
             C+ G+  ++D   C  V+ C    H C     C N+  S+ C C  G    + G+ C  
Sbjct: 842  ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 901

Query: 526  LDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNS 584
            ++ C A     C+H+C ++  S+ C C  G++L  DGK C   + C+A    C   C N 
Sbjct: 902  VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQECANI 959

Query: 585  DDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNNGNSYICKCSE-GFVLAED 642
              SY C C +G++LAEDG  C   D C +     C   C+N   SY C C E G+ +  +
Sbjct: 960  YGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTAN 1019

Query: 643  GRRCKKCTE 651
            GR CK   E
Sbjct: 1020 GRSCKDVDE 1028



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 31/113 (27%), Positives = 45/113 (39%), Gaps = 34/113 (30%)

Query: 577 CEHICVNSDDSYTCECLEGFRLAEDGKRCR------------------------------ 606
           C+H+C+N+  SY C C  GF L +DG+ CR                              
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675

Query: 607 ---RKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
              + + CK  +  C+ +C   G S IC C  G+ +  DG  C+   E   DL
Sbjct: 676 PLPQPNTCKD-NGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDL 727


>gi|4557733 latent transforming growth factor beta binding protein 2
            [Homo sapiens]
          Length = 1821

 Score =  218 bits (554), Expect = 3e-56
 Identities = 131/403 (32%), Positives = 185/403 (45%), Gaps = 15/403 (3%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
            C+N+P  Y C C  GY L+  Q  C   + C  +    +  C+N  GS+ C CY GY LA
Sbjct: 861  CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920

Query: 313  EDG--KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
              G  + C  ++ C         +C N +GSY C+C +G+ +   K  C  I+ C     
Sbjct: 921  TSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM-VRKGHCQDINECRHPGT 979

Query: 371  GCQHECVNTDDSYSC-HCLKGFTLNPDKKTCRRINYCALNKPG-CEH-ECVNMEESYYCR 427
                 CVN+  SY+C  C +G+       +C  +N C    PG C H +C N+E S+ C 
Sbjct: 980  CPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035

Query: 428  CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTCSRVD 486
            C +GY +  + K C  VD CA +      LCLNTE SF C  C  G+ +NED   C  +D
Sbjct: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLD 1095

Query: 487  YCLLSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC-EHSCVSSE 544
             C          C N   SF+C+ C  G+     G +C  +D C      C    C ++ 
Sbjct: 1096 ECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155

Query: 545  DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGK 603
             S+ C C +G+ L  +G  C   + C   +H   H  C+NS  S+ C C  GF  AE G 
Sbjct: 1156 GSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGT 1214

Query: 604  RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
             C+  D C +T       CVN   S+ C C  GF  + +   C
Sbjct: 1215 SCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGEC 1257



 Score =  206 bits (525), Expect = 6e-53
 Identities = 134/419 (31%), Positives = 182/419 (43%), Gaps = 35/419 (8%)

Query: 253  CINIPGSYVCRCKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCY 306
            C N  GSY C C QGYI+       D   CR    C       +  CVN PGS+ C  C 
Sbjct: 945  CTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCP------DGRCVNSPGSYTCLACE 998

Query: 307  SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
             GY   + G  CV V+ C +       +C N +GS+ C C +G+ +  D+K C  +D CA
Sbjct: 999  EGYR-GQSGS-CVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056

Query: 367  SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
            S        C+NT+ S++C  C  G+ +N D   C  ++ CA         C N   S+ 
Sbjct: 1057 SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFS 1116

Query: 426  CR-CHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF-----LINED 478
            C+ C  GY   P G +C  VD C      C    C NT  S+ C C +GF      + ED
Sbjct: 1117 CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCED 1176

Query: 479  LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
            +  C   ++C  + HG    C+N   SF C C  G V    G +C  +D CA  D     
Sbjct: 1177 VNECMGEEHC--APHG---ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGG 1231

Query: 539  SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI----CVNSDDSYTCE--C 592
             CV++E SF C C  G+    +   C   D C+  D+G        C NS  SY C   C
Sbjct: 1232 HCVNTEGSFNCLCETGFQPSPESGECVDIDECE--DYGDPVCGTWKCENSPGSYRCVLGC 1289

Query: 593  LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
              GF +A +G      +    T  G    C N   S+ C C +GF ++  G  C    E
Sbjct: 1290 QPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348



 Score =  194 bits (493), Expect = 3e-49
 Identities = 126/396 (31%), Positives = 175/396 (44%), Gaps = 21/396 (5%)

Query: 253  CINIPGSYVC-RCKQGYILNS----DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307
            C+N PGSY C  C++GY   S    D   C    +CA         C N+ GSF C C  
Sbjct: 985  CVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCA------HGKCTNLEGSFRCSCEQ 1038

Query: 308  GYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCA 366
            GY +  D K C  VD CAS        C+N +GS+ C  C  G+ +N D   C  +D CA
Sbjct: 1039 GYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA 1098

Query: 367  SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESY 424
                     C NT  S+SC  C  G+  +P   +C  ++ C   +  C   EC N   SY
Sbjct: 1099 FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY 1158

Query: 425  YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS 483
             C C +G+ L  NG  C  V+ C  ++H      CLN+  SF C C+ GF+  E   +C 
Sbjct: 1159 QCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217

Query: 484  RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHSCV 541
             VD C  +D      CVN + SF C C  G     +   C  +D C   GD  C    C 
Sbjct: 1218 DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCE 1277

Query: 542  SSEDSFVCQ--CFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599
            +S  S+ C   C  G+ +  +G      +       G    C N+D S+ C C +GF ++
Sbjct: 1278 NSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEIS 1337

Query: 600  EDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCS 634
              G  C   + C+     C   +C N   S++C C+
Sbjct: 1338 PSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373



 Score =  189 bits (480), Expect = 1e-47
 Identities = 121/360 (33%), Positives = 168/360 (46%), Gaps = 23/360 (6%)

Query: 249  CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ-CY 306
            CAH  C N+ GS+ C C+QGY + SD+  C+  D CA        LC+N  GSF C  C 
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079

Query: 307  SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYC 365
            +GY + EDG  C  +D CA         C N  GS+ C+ C  G+  +P   +C  +D C
Sbjct: 1080 NGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDEC 1139

Query: 366  ASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEES 423
                  C   EC NT  SY C C +GF L  +   C  +N C   +    H EC+N   S
Sbjct: 1140 EDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGS 1198

Query: 424  YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
            ++C C  G+     G +C  VD CA  D      C+NTE SF C C  GF  + +   C 
Sbjct: 1199 FFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258

Query: 484  RVDYCLLSDHG---C-EYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSCA----LGD 533
             +D C   D+G   C  + C N   S+ C   C  G  +  +G  C  +D CA     G 
Sbjct: 1259 DIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGS 1315

Query: 534  HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCEC 592
            HG    C +++ SF C C +G+ +   G  C   + C+ +   C   +C N + S+ C C
Sbjct: 1316 HG---FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC 1372



 Score =  167 bits (424), Expect = 3e-41
 Identities = 141/474 (29%), Positives = 188/474 (39%), Gaps = 75/474 (15%)

Query: 253  CINIPGSYVCR-CKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
            C N  GS+ C+ C  GY  +    +C   D C     +C    C N  GS+ C C  G+ 
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167

Query: 311  LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
            LA +G  C  V+ C  E H   H EC+N+ GS+ C C  GF       +C  +D CA+++
Sbjct: 1168 LA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTD 1226

Query: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA-LNKPGC-EHECVNMEESYYC- 426
                  CVNT+ S++C C  GF  +P+   C  I+ C     P C   +C N   SY C 
Sbjct: 1227 PCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV 1286

Query: 427  -RCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
              C  G+ + PNG  C  +D CA     G    C NT+ SF C C +GF I+     C  
Sbjct: 1287 LGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345

Query: 485  VDYCLLSDHGCEYS-CVNMDRSFACQCP---------EGHVLRSDGKTCAKLDSCALGDH 534
            V+ C L    C  + C N++ SF C C          EGH  R  G     +     GDH
Sbjct: 1346 VNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQSMSEAPTGDH 1404

Query: 535  G----------------------------CEHSCV----------------SSEDSFVCQ 550
                                          E  C                 S+E S +C 
Sbjct: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464

Query: 551  CFEGYILREDGKTCRRK-----DVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
              +GYI  E   T  +      D C     G C +  C+N+   Y C C  GF      K
Sbjct: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524

Query: 604  RCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
            +C   D C+     CE+  CVN   S+ C CS    L    +RC   T    DL
Sbjct: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDL 1576



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 104/437 (23%), Positives = 167/437 (38%), Gaps = 66/437 (15%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---C-EQLCVNV 297
            C+T +      C+N  GS+ C C+ G+  + +   C   D C  ED+    C    C N 
Sbjct: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDEC--EDYGDPVCGTWKCENS 1279

Query: 298  PGSFVC--QCYSGYALAEDGKRCVAVDYCASENH-GCEHECVNADGSYLCQCHEGFALNP 354
            PGS+ C   C  G+ +A +G  C+ +D CA++   G    C N DGS+ C C +GF ++P
Sbjct: 1280 PGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISP 1338

Query: 355  DKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
                C  ++ C      C    C N + S+ C C         ++   +  +C     G 
Sbjct: 1339 SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL-----EEYDAQEGHCRPRGAGG 1393

Query: 414  EHECVNMEESYYCRCHRGYTLDPNGKTCSRVD-HCAQQDHG-CEQLCLNTEDSFVCQCSE 471
            +    +M E+             +    +R+D +  Q+ H  C  +         C C++
Sbjct: 1394 Q----SMSEA---------PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440

Query: 472  GFLINEDLKTCSRVDYCLLSD---HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
            G    +    C   D    S+    G  Y  V    +F      G  + +D   C     
Sbjct: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTF------GQTMYTDADECV---- 1490

Query: 529  CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDD 586
               G   C +  C+++   +VC C  G+      K C   D CQ  D  CE+  CVN++ 
Sbjct: 1491 -IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--DLACENGECVNTEG 1547

Query: 587  SYTCECLEGFRLAEDGKRCRRK--------------DVC--KSTHHGCEHICVNNGNSYI 630
            S+ C C     L    +RC                 D+C  K T+  C      +  +Y 
Sbjct: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607

Query: 631  -CKCSEGFVLAEDGRRC 646
             C C +G   ++    C
Sbjct: 1608 ECCCQDGEAWSQQCALC 1624



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 4/143 (2%)

Query: 498  SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYIL 557
            +CVN+   + C C  G+ L      C   + C       +  C++   S+ C C+ GY L
Sbjct: 860  TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919

Query: 558  REDGKTCRRKDVCQAIDHG-CE-HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
               G T   +D+ +    G C    C N++ SY CEC +G+ +   G  C+  + C+   
Sbjct: 920  ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPG 978

Query: 616  HGCEHICVNNGNSYIC-KCSEGF 637
               +  CVN+  SY C  C EG+
Sbjct: 979  TCPDGRCVNSPGSYTCLACEEGY 1001



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 5/77 (6%)

Query: 329  HGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVNTDDSY 383
            +GCE+  CV     Y C C EGF L+     C  ++ C   N     C H  C NT+ SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 384  SCHCLKGFTLNPDKKTC 400
             CHC  G+        C
Sbjct: 1801 RCHCSPGYVAEAGPPHC 1817



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 5/78 (6%)

Query: 370  HGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC-ALNKPG--CEH-ECVNMEESY 424
            +GC++  CV   + Y+C C +GF L+     C  +N C  LN P   C H  C N E SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 425  YCRCHRGYTLDPNGKTCS 442
             C C  GY  +     C+
Sbjct: 1801 RCHCSPGYVAEAGPPHCT 1818



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 11/80 (13%)

Query: 412  GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD-------HGCEQLCLNTED 463
            GCE+  CV + E Y C C  G+ LD     C  V+ C   +       HG    C NTE 
Sbjct: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTEG 1798

Query: 464  SFVCQCSEGFLINEDLKTCS 483
            S+ C CS G++       C+
Sbjct: 1799 SYRCHCSPGYVAEAGPPHCT 1818



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)

Query: 288  HNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG---CEH-ECVNADGSY 342
            + CE   CV V   + C C+ G+ L      CV V+ C   N     C H  C N +GSY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 343  LCQCHEGFALNPDKKTCT 360
             C C  G+        CT
Sbjct: 1801 RCHCSPGYVAEAGPPHCT 1818



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 6/74 (8%)

Query: 575  HGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEH-ICVNNGNSY 629
            +GCE+  CV   + YTC+C EGF+L      C   + C   +     C H  C N   SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 630  ICKCSEGFVLAEDG 643
             C CS G+V AE G
Sbjct: 1801 RCHCSPGYV-AEAG 1813



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 5/81 (6%)

Query: 534  HGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG---CEH-ICVNSDDSY 588
            +GCE+  CV   + + C CFEG+ L      C   + C  ++     C H  C N++ SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800

Query: 589  TCECLEGFRLAEDGKRCRRKD 609
             C C  G+        C  K+
Sbjct: 1801 RCHCSPGYVAEAGPPHCTAKE 1821



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 6/115 (5%)

Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
           C+ IN C       + ECVN   SY C C  G  LDP+   C   D       G   LC 
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS-DKAISMLQG---LCY 675

Query: 460 NTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH 514
            +     C       I + +  CSRV     S+  CE   +    +F   CP GH
Sbjct: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFREICPAGH 728



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 11/80 (13%)

Query: 452  HGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-------LLSDHGCEYSCVNMD 503
            +GCE   C+   + + C C EGF ++     C  V+ C       +L  HG    C N +
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797

Query: 504  RSFACQCPEGHVLRSDGKTC 523
             S+ C C  G+V  +    C
Sbjct: 1798 GSYRCHCSPGYVAEAGPPHC 1817



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 11/84 (13%)

Query: 493  HGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-------ALGDHGCEHSCVSSE 544
            +GCE   CV +   + C C EG  L +    C  ++ C        L  HG    C ++E
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797

Query: 545  DSFVCQCFEGYILREDGKTCRRKD 568
             S+ C C  GY+       C  K+
Sbjct: 1798 GSYRCHCSPGYVAEAGPPHCTAKE 1821



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 11/61 (18%)

Query: 304 QCYSGYAL-----AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKT 358
           +C  GY        +D   C+ +  C       + ECVN  GSYLC C  G  L+P +  
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCK------DAECVNTRGSYLCTCRPGLMLDPSRSR 660

Query: 359 C 359
           C
Sbjct: 661 C 661



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 8/74 (10%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL------CVNVPGSFVCQCY 306
            C+ +   Y C C +G+ L++    C   D+   +D N   +      C N  GS+ C C 
Sbjct: 1748 CVRVREGYTCDCFEGFQLDAAHMAC--VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCS 1805

Query: 307  SGYALAEDGKRCVA 320
             GY        C A
Sbjct: 1806 PGYVAEAGPPHCTA 1819



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 16/42 (38%), Positives = 20/42 (47%)

Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
           C  I+ C +       ECVNT  SY C C  G  L+P +  C
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 11/61 (18%)

Query: 591 ECLEGFRL-----AEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRR 645
           EC +G++       +D   C    +CK         CVN   SY+C C  G +L     R
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAE------CVNTRGSYLCTCRPGLMLDPSRSR 660

Query: 646 C 646
           C
Sbjct: 661 C 661



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 1/57 (1%)

Query: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVA 320
           C QGY    + T C+  + C       +  CVN  GS++C C  G  L     RCV+
Sbjct: 608 CPQGY-KRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS 663



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 10/25 (40%), Positives = 17/25 (68%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTC 277
           C+N  GSY+C C+ G +L+  ++ C
Sbjct: 637 CVNTRGSYLCTCRPGLMLDPSRSRC 661



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)

Query: 249  CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQD 281
            C H +C N  GSY C C  GY+  +    C  ++
Sbjct: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 30/139 (21%), Positives = 52/139 (37%), Gaps = 9/139 (6%)

Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
           +CP+G+  R +   C  ++ C       +  CV++  S++C C  G +L      C    
Sbjct: 607 ECPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665

Query: 569 VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
               +    + +C  S    TC      R+ +    C R  V K+    CE   +    +
Sbjct: 666 AISML----QGLCYRSLGPGTCTLPLAQRITKQICCCSR--VGKAWGSECEKCPLPGTEA 719

Query: 629 Y--ICKCSEGFVLAEDGRR 645
           +  IC    G+  A    R
Sbjct: 720 FREICPAGHGYTYASSDIR 738


>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
          Length = 683

 Score =  207 bits (528), Expect = 3e-53
 Identities = 132/390 (33%), Positives = 179/390 (45%), Gaps = 36/390 (9%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 581 CVNSDDSYTC---ECLEGFRLAEDGKRCRR 607
           C N    + C   EC E +R +    RC R
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSA-ATRCER 570



 Score =  194 bits (493), Expect = 3e-49
 Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)

Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 622 CVNNGNSYIC---KCSEGF 637
           C N    + C   +C E +
Sbjct: 542 CFNIQGGFRCLAFECPENY 560



 Score =  172 bits (435), Expect = 2e-42
 Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)

Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371

Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431

Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489

Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549

Query: 466 VC---QCSEGF 473
            C   +C E +
Sbjct: 550 RCLAFECPENY 560



 Score =  161 bits (407), Expect = 3e-39
 Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
           C  ++  C H  +         C  G  L ++Q  C     D  ++E    ++ C     
Sbjct: 61  CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111

Query: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
              C C  G A    G+ C   + V Y C      C     E  + D   L +  +   +
Sbjct: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167

Query: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
             +++     D C      C+ +C +T D   C C  G+ L  D  +C  +N C      
Sbjct: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226

Query: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
           C     C+N   S+ C+    C  GY L  +  +C  +D C    H C  + +C NT  S
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285

Query: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
           F C    QC  GF I + L  C  ++ CL     C   ++C+N + S+ CQ     C  G
Sbjct: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344

Query: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
           + L  +G  C  +D CA     C   H CV+S  SF C+C  GY      + C   + CQ
Sbjct: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404

Query: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
                 C H C N+  SY C C  GFRL+ DG+ C   + C S+   C   C N   SY 
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462

Query: 631 CKCSEGFVLAE-DGRRCKKCTE 651
           C C  G+ L++ DG  C+   E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484



 Score =  140 bits (353), Expect = 6e-33
 Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)

Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
           C+ +C +  +   C C  GY L  +G +C  V+ C    H C   + C+NT  SF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
             C  G+ + ED  +C  +D C    H C  ++ C N   SF C    QC  G +  + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304

Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
             C  ++ C      C   H+C+++E S+ CQ     C  GY L E+G  C   D C   
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
              C   H CVNS  S+ CEC  G+      + C   + C+  + G  C H C N   SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422

Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
           +C CS GF L+ DGR C+   +C+  P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449


>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
          Length = 601

 Score =  207 bits (527), Expect = 4e-53
 Identities = 133/404 (32%), Positives = 183/404 (45%), Gaps = 38/404 (9%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 581 CVNSDDSYTC---ECLEGFR---LAEDGKRCRRKDVCKSTHHGC 618
           C N    + C   EC E +R     +  K+ R+     S+   C
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDC 585



 Score =  195 bits (496), Expect = 1e-49
 Identities = 125/390 (32%), Positives = 173/390 (44%), Gaps = 35/390 (8%)

Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 622 CVNNGNSYIC---KCSEGFVLAEDGRRCKK 648
           C N    + C   +C E +  +   ++ KK
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATQKSKK 571



 Score =  172 bits (435), Expect = 2e-42
 Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)

Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371

Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431

Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489

Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549

Query: 466 VC---QCSEGF 473
            C   +C E +
Sbjct: 550 RCLAFECPENY 560



 Score =  140 bits (353), Expect = 6e-33
 Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)

Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
           C+ +C +  +   C C  GY L  +G +C  V+ C    H C   + C+NT  SF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
             C  G+ + ED  +C  +D C    H C  ++ C N   SF C    QC  G +  + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304

Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
             C  ++ C      C   H+C+++E S+ CQ     C  GY L E+G  C   D C   
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
              C   H CVNS  S+ CEC  G+      + C   + C+  + G  C H C N   SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422

Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
           +C CS GF L+ DGR C+   +C+  P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 14/124 (11%)

Query: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
           D C  G   C+  C  + D  VC CF GY L  DG +C   + C    H C     C+N+
Sbjct: 178 DRCR-GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 585 DDSYTCE----CLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICK----CS 634
             S+ C+    C  G+ L ED   C+  D C+S  H C  + IC N   S+ C+    C 
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 635 EGFV 638
            GF+
Sbjct: 296 SGFI 299


>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
          Length = 566

 Score =  206 bits (524), Expect = 8e-53
 Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 581 CVNSDDSYTC---ECLEGFR 597
           C N    + C   EC E +R
Sbjct: 542 CFNIQGGFRCLAFECPENYR 561



 Score =  194 bits (493), Expect = 3e-49
 Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)

Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 622 CVNNGNSYIC---KCSEGF 637
           C N    + C   +C E +
Sbjct: 542 CFNIQGGFRCLAFECPENY 560



 Score =  172 bits (435), Expect = 2e-42
 Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)

Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371

Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431

Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489

Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549

Query: 466 VC---QCSEGF 473
            C   +C E +
Sbjct: 550 RCLAFECPENY 560



 Score =  161 bits (407), Expect = 3e-39
 Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
           C  ++  C H  +         C  G  L ++Q  C     D  ++E    ++ C     
Sbjct: 61  CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111

Query: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
              C C  G A    G+ C   + V Y C      C     E  + D   L +  +   +
Sbjct: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167

Query: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
             +++     D C      C+ +C +T D   C C  G+ L  D  +C  +N C      
Sbjct: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226

Query: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
           C     C+N   S+ C+    C  GY L  +  +C  +D C    H C  + +C NT  S
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285

Query: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
           F C    QC  GF I + L  C  ++ CL     C   ++C+N + S+ CQ     C  G
Sbjct: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344

Query: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
           + L  +G  C  +D CA     C   H CV+S  SF C+C  GY      + C   + CQ
Sbjct: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404

Query: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
                 C H C N+  SY C C  GFRL+ DG+ C   + C S+   C   C N   SY 
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462

Query: 631 CKCSEGFVLAE-DGRRCKKCTE 651
           C C  G+ L++ DG  C+   E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484



 Score =  140 bits (353), Expect = 6e-33
 Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)

Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
           C+ +C +  +   C C  GY L  +G +C  V+ C    H C   + C+NT  SF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
             C  G+ + ED  +C  +D C    H C  ++ C N   SF C    QC  G +  + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304

Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
             C  ++ C      C   H+C+++E S+ CQ     C  GY L E+G  C   D C   
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
              C   H CVNS  S+ CEC  G+      + C   + C+  + G  C H C N   SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422

Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
           +C CS GF L+ DGR C+   +C+  P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449


>gi|34734066 fibulin 1 isoform D [Homo sapiens]
          Length = 703

 Score =  206 bits (524), Expect = 8e-53
 Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
           C   C +     VC C  GY L SD  +C   + C    H+C   + C+N  GSF CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
             C +GY L ED   C  +D C S  H C  +  C N  GS+ C    QC  GF +    
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
             C  I+ C S +  C   H C+NT+ SY+C     +C +G+ LN +   C  ++ CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
              C   H CVN   S+ C C  GY  D   + C  V+ C +     C   C NT  S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
           C CS GF ++ D ++C  ++ C  S   C   C N+  S+ C C  G+ L   DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
           +D CAL  G H C + C++   SF C C   GY L  +G+ C+  D C    H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 581 CVNSDDSYTC---ECLEGFR 597
           C N    + C   EC E +R
Sbjct: 542 CFNIQGGFRCLAFECPENYR 561



 Score =  194 bits (494), Expect = 2e-49
 Identities = 130/409 (31%), Positives = 177/409 (43%), Gaps = 44/409 (10%)

Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
           C+Q C +     VC C+ GY L  DG  C  V+ C + +H C     C+N  GS+ CQ  
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245

Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
             C  G+ L  D  +C  ID C S  H C  +  C NT  S+ C     C  GF +    
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303

Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
             C  IN C      C   H C+N E SY C+     C RGY L+  G  C  VD CA  
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363

Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
              C +   C+N+  SF C+C  G+  +   + C  V+ C       C + C N   S+ 
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423

Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
           C C  G  L  DG++C  ++ C+     C   C +   S+ C C  GY L + DG TC  
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481

Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
            D C      H C + C+N   S+ C C   G+RLA +G+ C+  D C +  H C     
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541

Query: 622 CVNNGNSYIC---KCSEGFVLA--------EDGRRC-KKCTEGPIDLVF 658
           C N    + C   +C E +  +         D  RC K C    +  VF
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVF 590



 Score =  173 bits (439), Expect = 6e-43
 Identities = 103/285 (36%), Positives = 138/285 (48%), Gaps = 27/285 (9%)

Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
           C ++   C   H CIN  GSY C+     C +GY LN + T C   D CA     C +  
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371

Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
            CVN PGSF C+C +GY      + CV V+ C       C H+C N  GSYLC C  GF 
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431

Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
           L+ D ++C  I+ C+SS   C  EC N   SY C+C +G+ L+  D  TC  I+ CAL  
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489

Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
            G  C + C+N+  S+ C C   GY L PNG+ C  +D C    H C   + C N +  F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549

Query: 466 VC---QCSEGF------LINEDLKTCSRVDYCLLSDHGCEYSCVN 501
            C   +C E +      L  E   T   +  C  +D  C +  V+
Sbjct: 550 RCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVH 594



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 14/124 (11%)

Query: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
           D C  G   C+  C  + D  VC CF GY L  DG +C   + C    H C     C+N+
Sbjct: 178 DRCR-GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236

Query: 585 DDSYTCE----CLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICK----CS 634
             S+ C+    C  G+ L ED   C+  D C+S  H C  + IC N   S+ C+    C 
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295

Query: 635 EGFV 638
            GF+
Sbjct: 296 SGFI 299


>gi|110347437 latent transforming growth factor beta binding protein
           4 isoform c [Homo sapiens]
          Length = 1557

 Score =  193 bits (491), Expect = 6e-49
 Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
           CI+ P  Y C C  G+ L+   T C   D C      C    C N PGSF C C  G+  
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553

Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
                 C+ VD C      C+   C N  GS+LC C  G+   P   +C  +D C  S  
Sbjct: 554 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 613

Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
            C +  C N   S+ C C  GF  +  ++    ++ CA   P C    C N   S++C C
Sbjct: 614 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 670

Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
             G+     G  C  VD CA+    C    C NTE SF C C  GF  N     C  VD 
Sbjct: 671 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 730

Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
           C   L+  G E  CVN   SF C+ CP GH L      C  +D C+ G   C     C +
Sbjct: 731 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 786

Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
           +E SF C C  GY           D   C   D C    HG    C+N+D S+ C C  G
Sbjct: 787 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 841

Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
           +R    G  C   D C         IC N   S+ C C  G     D   C
Sbjct: 842 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 892



 Score =  188 bits (478), Expect = 2e-47
 Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N+PGS+ C C  G+  ++ +      D CA E   C    C N  GSF C C +G+  
Sbjct: 620  CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 676

Query: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
               G  C  VD CA     C +  C N +GS+ C C  GF  N     C  +D C +   
Sbjct: 677  RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 736

Query: 371  GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
                ECVN+  S+ C  C  G  L+  +  C  ++ C+   P C     C N E S+ C 
Sbjct: 737  CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 794

Query: 428  CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
            C  GY   P+G+   C+ V+ C + D    HG    CLNT+ SF C C+ G+       +
Sbjct: 795  CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 850

Query: 482  CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
            C  VD C   D      C N D SF C CP GH    D  +C  +D C   G   C    
Sbjct: 851  CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 910

Query: 540  CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
            C +S  S+ C   C  GY    +G TC   D CQ  ++G E      C N+  SY C   
Sbjct: 911  CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 967

Query: 592  CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
            C  G++    G  C+  D C++    G   +C N   S+ C C +G+  A DGR C    
Sbjct: 968  CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1026

Query: 651  E 651
            E
Sbjct: 1027 E 1027



 Score =  179 bits (455), Expect = 8e-45
 Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GS+ C C  G+        C+  D CA     C    C N  GSF C C  G+  
Sbjct: 659  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 718

Query: 312  AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
               G  C  VD C  ENH  C   ECVN+ GS+ C+ C  G  L+  +  CT +D C+S 
Sbjct: 719  NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 774

Query: 369  NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
               C     C NT+ S+ C C  G+     +   C  +N C        H EC+N + S+
Sbjct: 775  APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 834

Query: 425  YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
             C C  GY   P G +C  VD C+++D     +C NT+ SF C C  G     DL +C  
Sbjct: 835  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 894

Query: 485  VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
            VD C      L     CE    N   S+ C   C  G+    +G TC  +D C   G   
Sbjct: 895  VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 949

Query: 536  C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
            C    C ++  S+ C   C  GY        +D   CR +  C     G   +C N   S
Sbjct: 950  CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1004

Query: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
            + C C +G+  A DG+ C   + C++    C   +C N   S++C C
Sbjct: 1005 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1051



 Score =  127 bits (318), Expect = 6e-29
 Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)

Query: 253  CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
            C N  GS+ C C  GY   S       D   C   D C          C+N  GSF C C
Sbjct: 784  CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 838

Query: 306  YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
              GY     G  C+ VD C+ E+      C N DGS+ C C  G    PD  +C  +D C
Sbjct: 839  APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 898

Query: 366  ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
                        C N+  SY C   C  G+   P+  TC  ++ C    P       C N
Sbjct: 899  RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 957

Query: 420  MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
               SY C   C  GY   P G  C  VD C  +   G   +C N   SF C C +G+   
Sbjct: 958  TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016

Query: 477  EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
             D + C  V+ C      C  + C N++ SF C CP
Sbjct: 1017 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1052



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)

Query: 250  AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
            A  C N PGSY C   C  GY         D   CR +  C         +C N+PGSF 
Sbjct: 952  AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1006

Query: 303  CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
            C C  GY  A DG+ CV V+ C +    C    C N +GS+LC C +     +P    C 
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066

Query: 361  KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
                 A +  G Q +   +                              C+         
Sbjct: 1067 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1126

Query: 396  DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
            D    R + +    C + +    GC   +C   E + Y   C   RGY L P+G    R 
Sbjct: 1127 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1185

Query: 444  -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
             VD C   +D  C+  +C+NT   + C CS G+  +     C   D C   +  CE   C
Sbjct: 1186 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1245

Query: 500  VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
            VN   S+ C C    VL    + C   +S +L D+             C H  +  + ++
Sbjct: 1246 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1305

Query: 548  V-CQCFEGYILREDGKTCRRKD 568
              C C  G     D   C  +D
Sbjct: 1306 TECCCLYGEAWGMDCALCPAQD 1327



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
            CS  +   +  C N  GS+ C C  G+    D  +C   D C          Q C N PG
Sbjct: 857  CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 916

Query: 300  SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
            S+ C   C  GY    +G  C  VD C  + +G E      C N  GSY C   C  G+ 
Sbjct: 917  SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 973

Query: 352  LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
              P    C  +D C + +  G    C N   S+ C C +G+    D + C  +N C   +
Sbjct: 974  PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1032

Query: 411  PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
              C    C N+E S+ C C +     DP    C      A    G +             
Sbjct: 1033 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1092

Query: 459  ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
                L    S   Q   G    E   D       D  L  +   +  C  +   +   C 
Sbjct: 1093 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1151

Query: 512  EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
               + +  G   A+  S  L  HG  +   S + S      E  + R+  + C +  VC 
Sbjct: 1152 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1204

Query: 572  AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
                G    C N    +T   EC++              D C      CE   CVN   S
Sbjct: 1205 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1251

Query: 629  YICKCSEGFVLAEDGRRC 646
            Y C C    VL    RRC
Sbjct: 1252 YHCTCEPPLVLDGSQRRC 1269



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
           C+S    + C C  G+ L   G  C   D C+ +   C    C NS  S+ C C  GFR 
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553

Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
                 C   D C      C+   C N   S++C C  G+  A  G  C+   +CT+ P
Sbjct: 554 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 612



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
            C N+PGS+ C C QGY    D   C   + C      C   LC NV GSF+C C  S   
Sbjct: 998  CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1057

Query: 311  LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
                  RCV     A    G + +   +                        GS   +C+
Sbjct: 1058 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1117

Query: 348  EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
               A  PD       +  T  + C +   G    C+  +C  T+ + Y   C  G     
Sbjct: 1118 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1176

Query: 393  LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
             + D    R ++ C L +   C+   CVN    Y C C  GY        C   D CA +
Sbjct: 1177 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1236

Query: 451  DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
            +  CE   C+NT  S+ C C    +++   + C   +   L D+        G +  C +
Sbjct: 1237 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1296

Query: 502  --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
              +DR      C C  G     D   C   DS
Sbjct: 1297 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1328



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 283  CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
            C + D      CV VP  F C+C+ GY L      CV ++ C    A+        C+N 
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529

Query: 339  DGSYLCQCHEGFA 351
            DGS+ C C  GFA
Sbjct: 1530 DGSFRCICRPGFA 1542



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 412  GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
            GC +  CV + E + CRC  GY LD     C  ++ C + +          CLNT+ SF 
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534

Query: 467  CQCSEGF 473
            C C  GF
Sbjct: 1535 CICRPGF 1541



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)

Query: 519  DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
            + + C  LD C  G       CV   + F C+CF+GY L      C      D  +A   
Sbjct: 1466 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1519

Query: 576  GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
             C +  C+N+D S+ C C  GF        C
Sbjct: 1520 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)

Query: 330  GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
            GC +  CV     + C+C +G+ L+  +  C  I+ C    A+S       C+NTD S+ 
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534

Query: 385  CHCLKGF 391
            C C  GF
Sbjct: 1535 CICRPGF 1541



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)

Query: 239  AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
            A  C  L+      C+ +P  + CRC  GY L+  +  C   + C    A         C
Sbjct: 1467 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1526

Query: 295  VNVPGSFVCQCYSGYALAEDGKRC 318
            +N  GSF C C  G+A       C
Sbjct: 1527 LNTDGSFRCICRPGFAPTHQPHHC 1550



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)

Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
           L + +  CR   L A   H+C QLC         V+ P      C +G+        C  
Sbjct: 238 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 290

Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
           VD CA+    C+H EC N  G Y C C +GF L+  + +C
Sbjct: 291 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 329



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
           +C  +D CA+    CQH EC NT   Y+C C  GF L+  + +C
Sbjct: 287 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 329



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 371  GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
            GC +  CV   + ++C C  G+ L+  +  C  IN C       P C +  C+N + S+ 
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534

Query: 426  CRCHRGY 432
            C C  G+
Sbjct: 1535 CICRPGF 1541



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)

Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
           H C+     +  S     P+G       R +G +C  +D CA G   C+H  C ++   +
Sbjct: 255 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 312

Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
            C C +G++L     +C  + V       C                  FR+  DG     
Sbjct: 313 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 349

Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
                    GC    + N    IC CS   V    GR C+ C
Sbjct: 350 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 380



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)

Query: 570  CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
            C  +D      CV   + +TC C +G+RL      C   + C         C +  C+N 
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529

Query: 626  GNSYICKCSEGFVLAEDGRRC 646
              S+ C C  GF        C
Sbjct: 1530 DGSFRCICRPGFAPTHQPHHC 1550



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)

Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
           +C  VD CA         C NT   + C C +GFL++    +C  +   ++S+   +  C
Sbjct: 287 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 342

Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
             + R   C  P   +LR+  K   C      A G  GC+       + F  +C    GY
Sbjct: 343 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 398



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)

Query: 445  DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
            + C   D      C+   + F C+C +G+ ++     C  ++ C      S       C+
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1527

Query: 501  NMDRSFACQCPEGHVLRSDGKTCA 524
            N D SF C C  G         CA
Sbjct: 1528 NTDGSFRCICRPGFAPTHQPHHCA 1551



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)

Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
           +C  ++ CA     C+H EC N    Y C C  G+ LD +  +C      ++        
Sbjct: 287 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 345

Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
            +D GC    L      +C CS
Sbjct: 346 LRDGGCSLPILRNITKQICCCS 367



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)

Query: 488  CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
            C + D      CV +   F C+C +G+ L      C  ++ C   +     C ++ C+++
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529

Query: 544  EDSFVCQCFEGY 555
            + SF C C  G+
Sbjct: 1530 DGSFRCICRPGF 1541



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)

Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
           C H  C N  G Y C C  G++L+S +++C  Q + +     C
Sbjct: 300 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 342


>gi|110347412 latent transforming growth factor beta binding protein
           4 isoform b [Homo sapiens]
          Length = 1587

 Score =  193 bits (491), Expect = 6e-49
 Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
           CI+ P  Y C C  G+ L+   T C   D C      C    C N PGSF C C  G+  
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583

Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
                 C+ VD C      C+   C N  GS+LC C  G+   P   +C  +D C  S  
Sbjct: 584 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 643

Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
            C +  C N   S+ C C  GF  +  ++    ++ CA   P C    C N   S++C C
Sbjct: 644 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 700

Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
             G+     G  C  VD CA+    C    C NTE SF C C  GF  N     C  VD 
Sbjct: 701 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 760

Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
           C   L+  G E  CVN   SF C+ CP GH L      C  +D C+ G   C     C +
Sbjct: 761 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 816

Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
           +E SF C C  GY           D   C   D C    HG    C+N+D S+ C C  G
Sbjct: 817 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 871

Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
           +R    G  C   D C         IC N   S+ C C  G     D   C
Sbjct: 872 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 922



 Score =  188 bits (478), Expect = 2e-47
 Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N+PGS+ C C  G+  ++ +      D CA E   C    C N  GSF C C +G+  
Sbjct: 650  CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 706

Query: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
               G  C  VD CA     C +  C N +GS+ C C  GF  N     C  +D C +   
Sbjct: 707  RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 766

Query: 371  GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
                ECVN+  S+ C  C  G  L+  +  C  ++ C+   P C     C N E S+ C 
Sbjct: 767  CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 824

Query: 428  CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
            C  GY   P+G+   C+ V+ C + D    HG    CLNT+ SF C C+ G+       +
Sbjct: 825  CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 880

Query: 482  CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
            C  VD C   D      C N D SF C CP GH    D  +C  +D C   G   C    
Sbjct: 881  CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 940

Query: 540  CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
            C +S  S+ C   C  GY    +G TC   D CQ  ++G E      C N+  SY C   
Sbjct: 941  CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 997

Query: 592  CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
            C  G++    G  C+  D C++    G   +C N   S+ C C +G+  A DGR C    
Sbjct: 998  CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1056

Query: 651  E 651
            E
Sbjct: 1057 E 1057



 Score =  179 bits (455), Expect = 8e-45
 Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GS+ C C  G+        C+  D CA     C    C N  GSF C C  G+  
Sbjct: 689  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 748

Query: 312  AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
               G  C  VD C  ENH  C   ECVN+ GS+ C+ C  G  L+  +  CT +D C+S 
Sbjct: 749  NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 804

Query: 369  NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
               C     C NT+ S+ C C  G+     +   C  +N C        H EC+N + S+
Sbjct: 805  APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 864

Query: 425  YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
             C C  GY   P G +C  VD C+++D     +C NT+ SF C C  G     DL +C  
Sbjct: 865  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 924

Query: 485  VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
            VD C      L     CE    N   S+ C   C  G+    +G TC  +D C   G   
Sbjct: 925  VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 979

Query: 536  C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
            C    C ++  S+ C   C  GY        +D   CR +  C     G   +C N   S
Sbjct: 980  CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1034

Query: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
            + C C +G+  A DG+ C   + C++    C   +C N   S++C C
Sbjct: 1035 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081



 Score =  127 bits (318), Expect = 6e-29
 Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)

Query: 253  CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
            C N  GS+ C C  GY   S       D   C   D C          C+N  GSF C C
Sbjct: 814  CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 868

Query: 306  YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
              GY     G  C+ VD C+ E+      C N DGS+ C C  G    PD  +C  +D C
Sbjct: 869  APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 928

Query: 366  ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
                        C N+  SY C   C  G+   P+  TC  ++ C    P       C N
Sbjct: 929  RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 987

Query: 420  MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
               SY C   C  GY   P G  C  VD C  +   G   +C N   SF C C +G+   
Sbjct: 988  TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1046

Query: 477  EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
             D + C  V+ C      C  + C N++ SF C CP
Sbjct: 1047 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1082



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)

Query: 250  AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
            A  C N PGSY C   C  GY         D   CR +  C         +C N+PGSF 
Sbjct: 982  AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1036

Query: 303  CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
            C C  GY  A DG+ CV V+ C +    C    C N +GS+LC C +     +P    C 
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096

Query: 361  KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
                 A +  G Q +   +                              C+         
Sbjct: 1097 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1156

Query: 396  DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
            D    R + +    C + +    GC   +C   E + Y   C   RGY L P+G    R 
Sbjct: 1157 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1215

Query: 444  -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
             VD C   +D  C+  +C+NT   + C CS G+  +     C   D C   +  CE   C
Sbjct: 1216 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1275

Query: 500  VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
            VN   S+ C C    VL    + C   +S +L D+             C H  +  + ++
Sbjct: 1276 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1335

Query: 548  V-CQCFEGYILREDGKTCRRKD 568
              C C  G     D   C  +D
Sbjct: 1336 TECCCLYGEAWGMDCALCPAQD 1357



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
            CS  +   +  C N  GS+ C C  G+    D  +C   D C          Q C N PG
Sbjct: 887  CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 946

Query: 300  SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
            S+ C   C  GY    +G  C  VD C  + +G E      C N  GSY C   C  G+ 
Sbjct: 947  SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1003

Query: 352  LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
              P    C  +D C + +  G    C N   S+ C C +G+    D + C  +N C   +
Sbjct: 1004 PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1062

Query: 411  PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
              C    C N+E S+ C C +     DP    C      A    G +             
Sbjct: 1063 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1122

Query: 459  ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
                L    S   Q   G    E   D       D  L  +   +  C  +   +   C 
Sbjct: 1123 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1181

Query: 512  EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
               + +  G   A+  S  L  HG  +   S + S      E  + R+  + C +  VC 
Sbjct: 1182 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1234

Query: 572  AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
                G    C N    +T   EC++              D C      CE   CVN   S
Sbjct: 1235 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1281

Query: 629  YICKCSEGFVLAEDGRRC 646
            Y C C    VL    RRC
Sbjct: 1282 YHCTCEPPLVLDGSQRRC 1299



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
           C+S    + C C  G+ L   G  C   D C+ +   C    C NS  S+ C C  GFR 
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583

Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
                 C   D C      C+   C N   S++C C  G+  A  G  C+   +CT+ P
Sbjct: 584 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 642



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
            C N+PGS+ C C QGY    D   C   + C      C   LC NV GSF+C C  S   
Sbjct: 1028 CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1087

Query: 311  LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
                  RCV     A    G + +   +                        GS   +C+
Sbjct: 1088 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1147

Query: 348  EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
               A  PD       +  T  + C +   G    C+  +C  T+ + Y   C  G     
Sbjct: 1148 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1206

Query: 393  LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
             + D    R ++ C L +   C+   CVN    Y C C  GY        C   D CA +
Sbjct: 1207 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1266

Query: 451  DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
            +  CE   C+NT  S+ C C    +++   + C   +   L D+        G +  C +
Sbjct: 1267 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1326

Query: 502  --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
              +DR      C C  G     D   C   DS
Sbjct: 1327 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1358



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 283  CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
            C + D      CV VP  F C+C+ GY L      CV ++ C    A+        C+N 
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559

Query: 339  DGSYLCQCHEGFA 351
            DGS+ C C  GFA
Sbjct: 1560 DGSFRCICRPGFA 1572



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 412  GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
            GC +  CV + E + CRC  GY LD     C  ++ C + +          CLNT+ SF 
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564

Query: 467  CQCSEGF 473
            C C  GF
Sbjct: 1565 CICRPGF 1571



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)

Query: 519  DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
            + + C  LD C  G       CV   + F C+CF+GY L      C      D  +A   
Sbjct: 1496 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1549

Query: 576  GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
             C +  C+N+D S+ C C  GF        C
Sbjct: 1550 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)

Query: 330  GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
            GC +  CV     + C+C +G+ L+  +  C  I+ C    A+S       C+NTD S+ 
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564

Query: 385  CHCLKGF 391
            C C  GF
Sbjct: 1565 CICRPGF 1571



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)

Query: 239  AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
            A  C  L+      C+ +P  + CRC  GY L+  +  C   + C    A         C
Sbjct: 1497 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1556

Query: 295  VNVPGSFVCQCYSGYALAEDGKRC 318
            +N  GSF C C  G+A       C
Sbjct: 1557 LNTDGSFRCICRPGFAPTHQPHHC 1580



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)

Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
           L + +  CR   L A   H+C QLC         V+ P      C +G+        C  
Sbjct: 268 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 320

Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
           VD CA+    C+H EC N  G Y C C +GF L+  + +C
Sbjct: 321 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 359



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
           +C  +D CA+    CQH EC NT   Y+C C  GF L+  + +C
Sbjct: 317 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 359



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 371  GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
            GC +  CV   + ++C C  G+ L+  +  C  IN C       P C +  C+N + S+ 
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564

Query: 426  CRCHRGY 432
            C C  G+
Sbjct: 1565 CICRPGF 1571



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)

Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
           H C+     +  S     P+G       R +G +C  +D CA G   C+H  C ++   +
Sbjct: 285 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 342

Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
            C C +G++L     +C  + V       C                  FR+  DG     
Sbjct: 343 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 379

Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
                    GC    + N    IC CS   V    GR C+ C
Sbjct: 380 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 410



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)

Query: 570  CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
            C  +D      CV   + +TC C +G+RL      C   + C         C +  C+N 
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559

Query: 626  GNSYICKCSEGFVLAEDGRRC 646
              S+ C C  GF        C
Sbjct: 1560 DGSFRCICRPGFAPTHQPHHC 1580



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)

Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
           +C  VD CA         C NT   + C C +GFL++    +C  +   ++S+   +  C
Sbjct: 317 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 372

Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
             + R   C  P   +LR+  K   C      A G  GC+       + F  +C    GY
Sbjct: 373 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 428



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)

Query: 445  DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
            + C   D      C+   + F C+C +G+ ++     C  ++ C      S       C+
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1557

Query: 501  NMDRSFACQCPEGHVLRSDGKTCA 524
            N D SF C C  G         CA
Sbjct: 1558 NTDGSFRCICRPGFAPTHQPHHCA 1581



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)

Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
           +C  ++ CA     C+H EC N    Y C C  G+ LD +  +C      ++        
Sbjct: 317 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 375

Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
            +D GC    L      +C CS
Sbjct: 376 LRDGGCSLPILRNITKQICCCS 397



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)

Query: 488  CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
            C + D      CV +   F C+C +G+ L      C  ++ C   +     C ++ C+++
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559

Query: 544  EDSFVCQCFEGY 555
            + SF C C  G+
Sbjct: 1560 DGSFRCICRPGF 1571



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)

Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
           C H  C N  G Y C C  G++L+S +++C  Q + +     C
Sbjct: 330 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 372


>gi|110347431 latent transforming growth factor beta binding protein
           4 isoform a [Homo sapiens]
          Length = 1624

 Score =  193 bits (491), Expect = 6e-49
 Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
           CI+ P  Y C C  G+ L+   T C   D C      C    C N PGSF C C  G+  
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620

Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
                 C+ VD C      C+   C N  GS+LC C  G+   P   +C  +D C  S  
Sbjct: 621 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 680

Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
            C +  C N   S+ C C  GF  +  ++    ++ CA   P C    C N   S++C C
Sbjct: 681 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 737

Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
             G+     G  C  VD CA+    C    C NTE SF C C  GF  N     C  VD 
Sbjct: 738 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 797

Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
           C   L+  G E  CVN   SF C+ CP GH L      C  +D C+ G   C     C +
Sbjct: 798 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 853

Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
           +E SF C C  GY           D   C   D C    HG    C+N+D S+ C C  G
Sbjct: 854 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 908

Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
           +R    G  C   D C         IC N   S+ C C  G     D   C
Sbjct: 909 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 959



 Score =  188 bits (478), Expect = 2e-47
 Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N+PGS+ C C  G+  ++ +      D CA E   C    C N  GSF C C +G+  
Sbjct: 687  CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 743

Query: 312  AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
               G  C  VD CA     C +  C N +GS+ C C  GF  N     C  +D C +   
Sbjct: 744  RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 803

Query: 371  GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
                ECVN+  S+ C  C  G  L+  +  C  ++ C+   P C     C N E S+ C 
Sbjct: 804  CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 861

Query: 428  CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
            C  GY   P+G+   C+ V+ C + D    HG    CLNT+ SF C C+ G+       +
Sbjct: 862  CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 917

Query: 482  CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
            C  VD C   D      C N D SF C CP GH    D  +C  +D C   G   C    
Sbjct: 918  CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 977

Query: 540  CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
            C +S  S+ C   C  GY    +G TC   D CQ  ++G E      C N+  SY C   
Sbjct: 978  CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 1034

Query: 592  CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
            C  G++    G  C+  D C++    G   +C N   S+ C C +G+  A DGR C    
Sbjct: 1035 CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1093

Query: 651  E 651
            E
Sbjct: 1094 E 1094



 Score =  179 bits (455), Expect = 8e-45
 Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
            C N  GS+ C C  G+        C+  D CA     C    C N  GSF C C  G+  
Sbjct: 726  CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785

Query: 312  AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
               G  C  VD C  ENH  C   ECVN+ GS+ C+ C  G  L+  +  CT +D C+S 
Sbjct: 786  NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 841

Query: 369  NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
               C     C NT+ S+ C C  G+     +   C  +N C        H EC+N + S+
Sbjct: 842  APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 901

Query: 425  YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
             C C  GY   P G +C  VD C+++D     +C NT+ SF C C  G     DL +C  
Sbjct: 902  ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 961

Query: 485  VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
            VD C      L     CE    N   S+ C   C  G+    +G TC  +D C   G   
Sbjct: 962  VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 1016

Query: 536  C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
            C    C ++  S+ C   C  GY        +D   CR +  C     G   +C N   S
Sbjct: 1017 CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1071

Query: 588  YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
            + C C +G+  A DG+ C   + C++    C   +C N   S++C C
Sbjct: 1072 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1118



 Score =  127 bits (318), Expect = 6e-29
 Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)

Query: 253  CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
            C N  GS+ C C  GY   S       D   C   D C          C+N  GSF C C
Sbjct: 851  CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 905

Query: 306  YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
              GY     G  C+ VD C+ E+      C N DGS+ C C  G    PD  +C  +D C
Sbjct: 906  APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 965

Query: 366  ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
                        C N+  SY C   C  G+   P+  TC  ++ C    P       C N
Sbjct: 966  RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 1024

Query: 420  MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
               SY C   C  GY   P G  C  VD C  +   G   +C N   SF C C +G+   
Sbjct: 1025 TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1083

Query: 477  EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
             D + C  V+ C      C  + C N++ SF C CP
Sbjct: 1084 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1119



 Score = 93.6 bits (231), Expect = 8e-19
 Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)

Query: 250  AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
            A  C N PGSY C   C  GY         D   CR +  C         +C N+PGSF 
Sbjct: 1019 AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1073

Query: 303  CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
            C C  GY  A DG+ CV V+ C +    C    C N +GS+LC C +     +P    C 
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133

Query: 361  KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
                 A +  G Q +   +                              C+         
Sbjct: 1134 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1193

Query: 396  DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
            D    R + +    C + +    GC   +C   E + Y   C   RGY L P+G    R 
Sbjct: 1194 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1252

Query: 444  -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
             VD C   +D  C+  +C+NT   + C CS G+  +     C   D C   +  CE   C
Sbjct: 1253 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1312

Query: 500  VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
            VN   S+ C C    VL    + C   +S +L D+             C H  +  + ++
Sbjct: 1313 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1372

Query: 548  V-CQCFEGYILREDGKTCRRKD 568
              C C  G     D   C  +D
Sbjct: 1373 TECCCLYGEAWGMDCALCPAQD 1394



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)

Query: 242  CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
            CS  +   +  C N  GS+ C C  G+    D  +C   D C          Q C N PG
Sbjct: 924  CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 983

Query: 300  SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
            S+ C   C  GY    +G  C  VD C  + +G E      C N  GSY C   C  G+ 
Sbjct: 984  SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1040

Query: 352  LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
              P    C  +D C + +  G    C N   S+ C C +G+    D + C  +N C   +
Sbjct: 1041 PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1099

Query: 411  PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
              C    C N+E S+ C C +     DP    C      A    G +             
Sbjct: 1100 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1159

Query: 459  ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
                L    S   Q   G    E   D       D  L  +   +  C  +   +   C 
Sbjct: 1160 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1218

Query: 512  EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
               + +  G   A+  S  L  HG  +   S + S      E  + R+  + C +  VC 
Sbjct: 1219 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1271

Query: 572  AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
                G    C N    +T   EC++              D C      CE   CVN   S
Sbjct: 1272 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1318

Query: 629  YICKCSEGFVLAEDGRRC 646
            Y C C    VL    RRC
Sbjct: 1319 YHCTCEPPLVLDGSQRRC 1336



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
           C+S    + C C  G+ L   G  C   D C+ +   C    C NS  S+ C C  GFR 
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620

Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
                 C   D C      C+   C N   S++C C  G+  A  G  C+   +CT+ P
Sbjct: 621 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 679



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
            C N+PGS+ C C QGY    D   C   + C      C   LC NV GSF+C C  S   
Sbjct: 1065 CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1124

Query: 311  LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
                  RCV     A    G + +   +                        GS   +C+
Sbjct: 1125 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1184

Query: 348  EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
               A  PD       +  T  + C +   G    C+  +C  T+ + Y   C  G     
Sbjct: 1185 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1243

Query: 393  LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
             + D    R ++ C L +   C+   CVN    Y C C  GY        C   D CA +
Sbjct: 1244 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1303

Query: 451  DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
            +  CE   C+NT  S+ C C    +++   + C   +   L D+        G +  C +
Sbjct: 1304 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1363

Query: 502  --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
              +DR      C C  G     D   C   DS
Sbjct: 1364 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1395



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)

Query: 283  CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
            C + D      CV VP  F C+C+ GY L      CV ++ C    A+        C+N 
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596

Query: 339  DGSYLCQCHEGFA 351
            DGS+ C C  GFA
Sbjct: 1597 DGSFRCICRPGFA 1609



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 412  GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
            GC +  CV + E + CRC  GY LD     C  ++ C + +          CLNT+ SF 
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601

Query: 467  CQCSEGF 473
            C C  GF
Sbjct: 1602 CICRPGF 1608



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)

Query: 519  DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
            + + C  LD C  G       CV   + F C+CF+GY L      C      D  +A   
Sbjct: 1533 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1586

Query: 576  GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
             C +  C+N+D S+ C C  GF        C
Sbjct: 1587 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)

Query: 330  GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
            GC +  CV     + C+C +G+ L+  +  C  I+ C    A+S       C+NTD S+ 
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601

Query: 385  CHCLKGF 391
            C C  GF
Sbjct: 1602 CICRPGF 1608



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)

Query: 239  AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
            A  C  L+      C+ +P  + CRC  GY L+  +  C   + C    A         C
Sbjct: 1534 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1593

Query: 295  VNVPGSFVCQCYSGYALAEDGKRC 318
            +N  GSF C C  G+A       C
Sbjct: 1594 LNTDGSFRCICRPGFAPTHQPHHC 1617



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)

Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
           L + +  CR   L A   H+C QLC         V+ P      C +G+        C  
Sbjct: 305 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 357

Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
           VD CA+    C+H EC N  G Y C C +GF L+  + +C
Sbjct: 358 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 396



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
           +C  +D CA+    CQH EC NT   Y+C C  GF L+  + +C
Sbjct: 354 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 396



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)

Query: 371  GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
            GC +  CV   + ++C C  G+ L+  +  C  IN C       P C +  C+N + S+ 
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601

Query: 426  CRCHRGY 432
            C C  G+
Sbjct: 1602 CICRPGF 1608



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)

Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
           H C+     +  S     P+G       R +G +C  +D CA G   C+H  C ++   +
Sbjct: 322 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 379

Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
            C C +G++L     +C  + V       C                  FR+  DG     
Sbjct: 380 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 416

Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
                    GC    + N    IC CS   V    GR C+ C
Sbjct: 417 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 447



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)

Query: 570  CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
            C  +D      CV   + +TC C +G+RL      C   + C         C +  C+N 
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596

Query: 626  GNSYICKCSEGFVLAEDGRRC 646
              S+ C C  GF        C
Sbjct: 1597 DGSFRCICRPGFAPTHQPHHC 1617



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)

Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
           +C  VD CA         C NT   + C C +GFL++    +C  +   ++S+   +  C
Sbjct: 354 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 409

Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
             + R   C  P   +LR+  K   C      A G  GC+       + F  +C    GY
Sbjct: 410 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 465



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)

Query: 445  DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
            + C   D      C+   + F C+C +G+ ++     C  ++ C      S       C+
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1594

Query: 501  NMDRSFACQCPEGHVLRSDGKTCA 524
            N D SF C C  G         CA
Sbjct: 1595 NTDGSFRCICRPGFAPTHQPHHCA 1618



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)

Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
           +C  ++ CA     C+H EC N    Y C C  G+ LD +  +C      ++        
Sbjct: 354 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 412

Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
            +D GC    L      +C CS
Sbjct: 413 LRDGGCSLPILRNITKQICCCS 434



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)

Query: 488  CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
            C + D      CV +   F C+C +G+ L      C  ++ C   +     C ++ C+++
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596

Query: 544  EDSFVCQCFEGY 555
            + SF C C  G+
Sbjct: 1597 DGSFRCICRPGF 1608



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)

Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
           C H  C N  G Y C C  G++L+S +++C  Q + +     C
Sbjct: 367 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 409


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  187 bits (476), Expect = 3e-47
 Identities = 127/415 (30%), Positives = 173/415 (41%), Gaps = 53/415 (12%)

Query: 263  RCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
            +C  G+ L+S    C  +D CA   + C   C N  G++ C C  G  +A DG+ C  +D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAA-GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 323  YCASENHGCE--HECVNADGSYLC--QCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
             CA   H C    +C N  GSY C  +C  GF    D  +C  I+ C  S+  C   C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQRCFN 5208

Query: 379  TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC--RCHRGYTLDP 436
               S+ C C  G+ L   K  C  +N C  N    +  C N    Y C   C  G T   
Sbjct: 5209 AIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266

Query: 437  NGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHG 494
            NG TC  +D C    H C   Q+C NT  S+ C C  G+      + C  ++ C      
Sbjct: 5267 NG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKP 5325

Query: 495  CEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVS------------ 542
            C + C N   SF C CP G  L  DGK+CA L+   L ++G ++S  +            
Sbjct: 5326 CAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQ 5383

Query: 543  -----SEDSFVCQCFEGY---------ILREDGKTC-----RRKDVCQAIDH-----GCE 578
                  + S +   +  Y           R   KTC        D C  ID       C+
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQ 5443

Query: 579  HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC--KSTHHGCEHICVNNGNSYIC 631
            H C N+  SY C C  G++L  +GK C+  D C  ++ H G   +C N   SY C
Sbjct: 5444 HECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQC 5498



 Score =  182 bits (462), Expect = 1e-45
 Identities = 128/415 (30%), Positives = 174/415 (41%), Gaps = 65/415 (15%)

Query: 304  QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
            QC SG+ L   G  C   D CA+ N  C H C NA G+Y C C +G  +  D +TC  ID
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149

Query: 364  YCASSNHGCQ--HECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
             CA   H C    +C NT  SY C   C  GF    D  +C+ IN C  + P C   C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQRCFN 5208

Query: 420  MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVC--QCSEGFLINE 477
               S++C C  GY L   G+ C  V+ C Q     +Q C NT   + C   C  G    E
Sbjct: 5209 AIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266

Query: 478  DLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
            +  TC  +D C    H C Y+  C N   S+ C CP G+  +  G+ C  ++ C      
Sbjct: 5267 N-GTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKP 5325

Query: 536  CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSD---------- 585
            C H C ++  SF C C  G  L  DGK+C   +  +  ++G ++   N            
Sbjct: 5326 CAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQ 5383

Query: 586  ------------DSYT-----------------CECLEGFRLAEDGKRCRRKDVCKSTHH 616
                         SY+                   C EG   + D   C   D C++T  
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENT-D 5440

Query: 617  GCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTE-----GPIDLVFVIDGS 663
             C+H C N   SY C C  G+ L  +G+ C+   +C E     GP  + F + GS
Sbjct: 5441 ACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGS 5495



 Score =  179 bits (453), Expect = 1e-44
 Identities = 120/391 (30%), Positives = 163/391 (41%), Gaps = 58/391 (14%)

Query: 249  CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVC--Q 304
            C+H C N  G+Y C C +G  + +D  TC+  D CA+  H C   Q C N  GS+ C  +
Sbjct: 5117 CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVR 5176

Query: 305  CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDY 364
            C SG+    DG  C  ++ C  E+  C   C NA GS+ C C  G+ L   K  C  ++ 
Sbjct: 5177 CGSGFRRTSDGLSCQDINEC-QESSPCHQRCFNAIGSFHCGCEPGYQLKGRK--CMDVNE 5233

Query: 365  CASSNHGCQHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGCEHE--CVNM 420
            C  +       C NT   Y C   C  G T   +  TC  I+ C      C +   C N 
Sbjct: 5234 CRQNVCRPDQHCKNTRGGYKCIDLCPNGMT-KAENGTCIDIDECKDGTHQCRYNQICENT 5292

Query: 421  EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
              SY C C RGY     G+ C  ++ C Q    C   C NT  SF C C  G  +  D K
Sbjct: 5293 RGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGK 5352

Query: 481  TCSRVDYCLLSDHGCEYSCVNM-------------------------------------- 502
            +C+ ++   L ++G +YS  N+                                      
Sbjct: 5353 SCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410

Query: 503  -DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDG 561
              R+    CPEG     D  TC  +D C   D  C+H C ++  S+ C C  GY L  +G
Sbjct: 5411 TRRTIRKTCPEGSEASHD--TCVDIDECENTD-ACQHECKNTFGSYQCICPPGYQLTHNG 5467

Query: 562  KTCRRKDVC--QAIDHGCEHICVNSDDSYTC 590
            KTC+  D C  Q +  G   +C N   SY C
Sbjct: 5468 KTCQDIDECLEQNVHCGPNRMCFNMRGSYQC 5498



 Score =  144 bits (363), Expect = 4e-34
 Identities = 91/281 (32%), Positives = 125/281 (44%), Gaps = 14/281 (4%)

Query: 374  HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
            H  ++  D  S  C  GFTL+     C   + CA   P C H C N   +YYC C +G T
Sbjct: 5080 HASISKGDR-SNQCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLT 5137

Query: 434  LDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLKTCSRVDYCL 489
            +  +G+TC  +D CA   H C   Q C NT  S+ C  +C  GF    D  +C  ++ C 
Sbjct: 5138 IAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ 5197

Query: 490  LSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVC 549
             S   C   C N   SF C C  G+ L+  G+ C  ++ C       +  C ++   + C
Sbjct: 5198 ESSP-CHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKC 5254

Query: 550  --QCFEGYILREDGKTCRRKDVCQAIDHGCEH--ICVNSDDSYTCECLEGFRLAEDGKRC 605
               C  G    E+G TC   D C+   H C +  IC N+  SY C C  G+R    G+ C
Sbjct: 5255 IDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPC 5313

Query: 606  RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
               + C+     C H C N   S+ C C  G  L  DG+ C
Sbjct: 5314 MDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSC 5354



 Score =  117 bits (293), Expect = 5e-26
 Identities = 92/319 (28%), Positives = 127/319 (39%), Gaps = 64/319 (20%)

Query: 237  CTAHMCSTLEHNCAHFCINIPGSYVC--RCKQGYILNSDQTTCRIQDLCAMEDHNCE--Q 292
            C  ++C   +H     C N  G Y C   C  G +  ++  TC   D C    H C   Q
Sbjct: 5234 CRQNVCRPDQH-----CKNTRGGYKCIDLCPNG-MTKAENGTCIDIDECKDGTHQCRYNQ 5287

Query: 293  LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFAL 352
            +C N  GS+ C C  GY     G+ C+ ++ C      C H+C N  GS+ C C  G  L
Sbjct: 5288 ICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHL 5347

Query: 353  NPDKKTCTKIDYCASSNHGCQHECVNTD----------------------DSYSCH---- 386
              D K+C  ++     N+G Q+   N                         SYS +    
Sbjct: 5348 LGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSR 5405

Query: 387  -------------CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
                         C +G   + D  TC  I+ C  N   C+HEC N   SY C C  GY 
Sbjct: 5406 TSLSRTRRTIRKTCPEGSEASHD--TCVDIDECE-NTDACQHECKNTFGSYQCICPPGYQ 5462

Query: 434  LDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC---QCSEGF----LINEDLKTCSR 484
            L  NGKTC  +D C +Q+  C   ++C N   S+ C    C   +    +    LK C  
Sbjct: 5463 LTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPP 5522

Query: 485  VDY-CLLSDHGCEYSCVNM 502
             D  C LS +  EY  V++
Sbjct: 5523 NDLECALSPYALEYKLVSL 5541


>gi|194328809 latent transforming growth factor beta binding protein 3
            isoform 1 [Homo sapiens]
          Length = 1303

 Score =  182 bits (461), Expect = 2e-45
 Identities = 130/452 (28%), Positives = 182/452 (40%), Gaps = 60/452 (13%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309
            FCIN PG Y C C  GY L + +   C   D C       +  C N PGSF C  C  GY
Sbjct: 675  FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734

Query: 310  ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
              ++ G  C  V+ CA  +      C N  GS+ C C +G+A  PD ++C  +D C + +
Sbjct: 735  R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793

Query: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
                  C NT  S+ C CL G+ L+ D+  C  I+ C         +C+N   SY C C 
Sbjct: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853

Query: 430  RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
            +G+ L   G+ C  +D C+Q    C     C N + S+VC C EGF   +D   C  V+ 
Sbjct: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912

Query: 488  ------CLLS-----------------------------DHGCEYSC-VNMDRSFACQCP 511
                  C L+                             DH   Y C V     F   CP
Sbjct: 913  PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972

Query: 512  EGHVLRSDGKTC-------AKLDSCAL-GDHGC-EHSCVSSEDSFVCQCFEGYILREDGK 562
            +G     D             +D C L G   C E  CV+++  + C C +G+    DG 
Sbjct: 973  DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY--DGN 1030

Query: 563  TCRRKDVCQAIDH-GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-----DVCKSTH 615
                 DV + +D   C + +C N+   Y C C      +   ++C        D C+   
Sbjct: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA 1090

Query: 616  HGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647
                  CVN   SY C+C   +V    GR C+
Sbjct: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ 1122



 Score =  176 bits (446), Expect = 9e-44
 Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)

Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
           C   ++ C H  C+  P  Y C C  GY  +     C   + C  E     + +C+N  G
Sbjct: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637

Query: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355
           S+ C C  GY L     G+ CV ++ CA + H C     C+N  G Y C C+ G+ L   
Sbjct: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696

Query: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
           +   C  ID C   +     +C N   S+ C   +    +     CR +N CA   P   
Sbjct: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756

Query: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474
             C N+  S+ C C +GY   P+G++C  VD C   D     +C NT  SF CQC  G+ 
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816

Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
           ++ D   C  +D C          C+N + S+ C CP+GH L   G+ C  +D C+    
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875

Query: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591
            C    +C + + S+VC C EG+   +D   C   +      H  +   +N DD+  C+
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930



 Score =  171 bits (434), Expect = 2e-42
 Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)

Query: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379
           D C    + C H ECV     Y C C+ G+  +P  + C  ++ C +   G  +  C+NT
Sbjct: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635

Query: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434
             SY+CHC +G+ L+     ++C  +N CA  KP   G    C+N    Y C C+ GY L
Sbjct: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693

Query: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492
             +    C  +D C       +  C N   SF C  C  G+  ++    C  V+ C    
Sbjct: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752

Query: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552
                 C N+  SF C C +G+    DG++C  +D C  GD      C ++  SF CQC 
Sbjct: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812

Query: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612
            GY L  D   C   D C          C+N++ SY C C +G RL   G++C+  D C 
Sbjct: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871

Query: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
                C     C N   SY+C C EGF   +D   C++
Sbjct: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909



 Score =  152 bits (384), Expect = 1e-36
 Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)

Query: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417
           T+ D C  + + C H ECV     YSCHC  G+  +P  + C  +N C     G     C
Sbjct: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632

Query: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
           +N   SY C C+RGY L     G++C  ++ CA + H C     C+N    + C C  G+
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691

Query: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532
            +       C  +D C       +  C N   SF C   +       G  C  ++ CA G
Sbjct: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751

Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
                  C +   SF C C +GY    DG++C   D C+A D     IC N+  S+ C+C
Sbjct: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811

Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649
           L G+ L+ D   C   D C          C+N   SY C C +G  L   GR+C+   +C
Sbjct: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870

Query: 650 TEGP 653
           ++ P
Sbjct: 871 SQDP 874



 Score =  125 bits (314), Expect = 2e-28
 Identities = 128/540 (23%), Positives = 179/540 (33%), Gaps = 145/540 (26%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
            +C N+PGS+ C C QGY    D  +C   D C   D     +C N PGSF CQC SGY L
Sbjct: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817

Query: 312  AED----------------------------------------GKRCVAVDYCASENHGC 331
            + D                                        G++C  +D C+ +   C
Sbjct: 818  SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLC 877

Query: 332  --EHECVNADGSYLCQCHEGFALNPDKKTCTKID----------------YCAS---SNH 370
                 C N  GSY+C C EGF    D+  C +++                +C S   +N 
Sbjct: 878  LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937

Query: 371  GCQHECVNTDDSYSCHCL-------------------KGFT-----LNPDKKTCRRINYC 406
              Q  C +    +  HC                    KG+T     +N      R I+ C
Sbjct: 938  TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997

Query: 407  AL--NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDS 464
             L  ++   E +CVN +  Y C C +G+  D N   C  VD C  + +    +C NT   
Sbjct: 998  MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGG 1057

Query: 465  FVCQCSEGFLINEDLKTCSR-----VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSD 519
            + C C+     +   + C       VD C          CVN+  S+ C+C    V    
Sbjct: 1058 YRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPS 1117

Query: 520  GKTCAKLDSCALGDHGCEHSCVSS--EDSFVCQCFEGYILREDGKTCRR----------- 566
            G+ C   +S A         C S   ED        G  L  D   CR+           
Sbjct: 1118 GRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC 1177

Query: 567  ---------------------------------KDVCQAIDHGCEHI---CVNSDDSYTC 590
                                             +D  +     C  +   CV       C
Sbjct: 1178 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVC 1237

Query: 591  ECLEGFRLAEDGKRCRRKDVCKSTHHG---CE-HICVNNGNSYICKCSEGFVLAEDGRRC 646
            EC  GF+L     RC   D C+  +     C+   CVN   S+ C C  GF  +     C
Sbjct: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)

Query: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298
           H C  L++        + G     C QGY  LNS  T C+  + CAM        C+N P
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374

Query: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350
           GS+ C C  G++L     +C+A        C    S  H C+H         LC C  G 
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434

Query: 351 ALNPDKKTC 359
           A     + C
Sbjct: 435 AWGARCQRC 443



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308
            C+  PG  VC C  G+ L++ +  C   D C   +     C+ + CVN  GSF C C +G
Sbjct: 1228 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287

Query: 309  YALAEDGKRCV 319
            +A +     CV
Sbjct: 1288 FARSRPHGACV 1298



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)

Query: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
           H C QL          V G     C  GY    +   C  ++ CA     C H +C+N  
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374

Query: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390
           GSY C C  G +L P +  C      +   C    S  H CQH          C C  G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605
           C +GY  R +   C+  + C A+   C H  C+N+  SY C C  G  L     +C    
Sbjct: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652
              K +C    S  H C+H         +C CS G      G RC++C T+G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)

Query: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449
           C+ IN CA+  PG C H +C+N   SY C C  G++L P+   C        S       
Sbjct: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410

Query: 450 QDHGCEQLCLNTEDSFVCQCSEG 472
            +H C+          +C CS G
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)

Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375
           +C  + Y   +  G     V AD      C +G+    +   C  I+ CA     C+H +
Sbjct: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369

Query: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400
           C+N   SY C C  G +L P +  C
Sbjct: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)

Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564
           CP+G+  R +   C  ++ CA+    C H  C+++  S+ C C  G+ L      C    
Sbjct: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
              K +C  +   +H C+H          C C  G      G RC+R
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)

Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531
           +D+  C+    C   D      C+N   S+ C CP GH L      C   K +  +L   
Sbjct: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407

Query: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572
               +H C+H   +     +C C  G   +  G  C+R         K++C A
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)

Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
           C ++ Y  + KPG     V  +      C +GY    N   C  ++ CA         CL
Sbjct: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371

Query: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511
           N   S+ C C  G  +      C         + + L+S +H C++          C C 
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431

Query: 512 EG 513
            G
Sbjct: 432 VG 433


>gi|18497288 latent transforming growth factor beta binding protein
           3 isoform 2 [Homo sapiens]
          Length = 1256

 Score =  176 bits (446), Expect = 9e-44
 Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)

Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
           C   ++ C H  C+  P  Y C C  GY  +     C   + C  E     + +C+N  G
Sbjct: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637

Query: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355
           S+ C C  GY L     G+ CV ++ CA + H C     C+N  G Y C C+ G+ L   
Sbjct: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696

Query: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
           +   C  ID C   +     +C N   S+ C   +    +     CR +N CA   P   
Sbjct: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756

Query: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474
             C N+  S+ C C +GY   P+G++C  VD C   D     +C NT  SF CQC  G+ 
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816

Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
           ++ D   C  +D C          C+N + S+ C CP+GH L   G+ C  +D C+    
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875

Query: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591
            C    +C + + S+VC C EG+   +D   C   +      H  +   +N DD+  C+
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930



 Score =  175 bits (444), Expect = 2e-43
 Identities = 120/411 (29%), Positives = 172/411 (41%), Gaps = 26/411 (6%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309
            FCIN PG Y C C  GY L + +   C   D C       +  C N PGSF C  C  GY
Sbjct: 675  FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734

Query: 310  ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
              ++ G  C  V+ CA  +      C N  GS+ C C +G+A  PD ++C  +D C + +
Sbjct: 735  R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793

Query: 370  HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
                  C NT  S+ C CL G+ L+ D+  C  I+ C         +C+N   SY C C 
Sbjct: 794  VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853

Query: 430  RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
            +G+ L   G+ C  +D C+Q    C     C N + S+VC C EGF   +D   C  V+ 
Sbjct: 854  QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE- 911

Query: 488  CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSD--GKTCAKLDSCALGDHGCEHSC-VSSE 544
                 H  +   +N D +  C      VL ++   + C        GDH   + C V S 
Sbjct: 912  ---QPHHKKECYLNFDDTVFCD----SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964

Query: 545  DSFVCQCFEGYILREDGKTCR-----RKDVCQAIDHGCEHI----CVNSDDSYTCECLEG 595
              F   C +G    +D           +D+ + +  G E      CVN+   Y C C +G
Sbjct: 965  AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQG 1024

Query: 596  FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
            F    +   C   D C    +    +C N    Y C C+     +   R+C
Sbjct: 1025 FYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQC 1075



 Score =  171 bits (434), Expect = 2e-42
 Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)

Query: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379
           D C    + C H ECV     Y C C+ G+  +P  + C  ++ C +   G  +  C+NT
Sbjct: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635

Query: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434
             SY+CHC +G+ L+     ++C  +N CA  KP   G    C+N    Y C C+ GY L
Sbjct: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693

Query: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492
             +    C  +D C       +  C N   SF C  C  G+  ++    C  V+ C    
Sbjct: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752

Query: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552
                 C N+  SF C C +G+    DG++C  +D C  GD      C ++  SF CQC 
Sbjct: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812

Query: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612
            GY L  D   C   D C          C+N++ SY C C +G RL   G++C+  D C 
Sbjct: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871

Query: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
                C     C N   SY+C C EGF   +D   C++
Sbjct: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909



 Score =  152 bits (384), Expect = 1e-36
 Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)

Query: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417
           T+ D C  + + C H ECV     YSCHC  G+  +P  + C  +N C     G     C
Sbjct: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632

Query: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
           +N   SY C C+RGY L     G++C  ++ CA + H C     C+N    + C C  G+
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691

Query: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532
            +       C  +D C       +  C N   SF C   +       G  C  ++ CA G
Sbjct: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751

Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
                  C +   SF C C +GY    DG++C   D C+A D     IC N+  S+ C+C
Sbjct: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811

Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649
           L G+ L+ D   C   D C          C+N   SY C C +G  L   GR+C+   +C
Sbjct: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870

Query: 650 TEGP 653
           ++ P
Sbjct: 871 SQDP 874



 Score =  132 bits (332), Expect = 2e-30
 Identities = 131/504 (25%), Positives = 177/504 (35%), Gaps = 120/504 (23%)

Query: 252  FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
            +C N+PGS+ C C QGY    D  +C   D C   D     +C N PGSF CQC SGY L
Sbjct: 758  WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817

Query: 312  AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS--- 368
            + D   C  +D C         +C+N +GSY C C +G  L   +K C  ID C+     
Sbjct: 818  SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSL 876

Query: 369  ---------------------------NHGCQH--------EC-VNTDDSYSC------- 385
                                        HGC+         EC +N DD+  C       
Sbjct: 877  CLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN 936

Query: 386  ----------------HCL-------------------KGFT-----LNPDKKTCRRINY 405
                            HC                    KG+T     +N      R I+ 
Sbjct: 937  VTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDE 996

Query: 406  CAL--NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTED 463
            C L  ++   E +CVN +  Y C C +G+  D N   C  VD C  + +    +C NT  
Sbjct: 997  CMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRG 1056

Query: 464  SFVCQCSEGFLINEDLKTC----------SRVDYCLLSDHGCEYSCVNMDRSFA-----C 508
             + C C+     +   + C           R D C  S  G +  C       A     C
Sbjct: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW-SQRGEDGMCAGPLAGPALTFDDC 1115

Query: 509  QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGYILREDGKTCRR 566
             C +G   R  G  C        G H C  S  S  +SF        G   R++  +   
Sbjct: 1116 CCRQG---RGWGAQCRPCPPRGAGSH-CPTS-QSESNSFWDTSPLLLGKPPRDEDSSEED 1170

Query: 567  KDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CE-HIC 622
             D C+ +   C    V       CEC  GF+L     RC   D C+  +     C+   C
Sbjct: 1171 SDECRCVSGRC----VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1226

Query: 623  VNNGNSYICKCSEGFVLAEDGRRC 646
            VN   S+ C C  GF  +     C
Sbjct: 1227 VNTSGSFRCVCKAGFARSRPHGAC 1250



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)

Query: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298
           H C  L++        + G     C QGY  LNS  T C+  + CAM        C+N P
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374

Query: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350
           GS+ C C  G++L     +C+A        C    S  H C+H         LC C  G 
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434

Query: 351 ALNPDKKTC 359
           A     + C
Sbjct: 435 AWGARCQRC 443



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)

Query: 253  CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308
            C+  PG  VC C  G+ L++ +  C   D C   +     C+ + CVN  GSF C C +G
Sbjct: 1181 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1240

Query: 309  YALAEDGKRCV 319
            +A +     CV
Sbjct: 1241 FARSRPHGACV 1251



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)

Query: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
           H C QL          V G     C  GY    +   C  ++ CA     C H +C+N  
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374

Query: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390
           GSY C C  G +L P +  C      +   C    S  H CQH          C C  G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605
           C +GY  R +   C+  + C A+   C H  C+N+  SY C C  G  L     +C    
Sbjct: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652
              K +C    S  H C+H         +C CS G      G RC++C T+G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)

Query: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449
           C+ IN CA+  PG C H +C+N   SY C C  G++L P+   C        S       
Sbjct: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410

Query: 450 QDHGCEQLCLNTEDSFVCQCSEG 472
            +H C+          +C CS G
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVG 433



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)

Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375
           +C  + Y   +  G     V AD      C +G+    +   C  I+ CA     C+H +
Sbjct: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369

Query: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400
           C+N   SY C C  G +L P +  C
Sbjct: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)

Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564
           CP+G+  R +   C  ++ CA+    C H  C+++  S+ C C  G+ L      C    
Sbjct: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398

Query: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
              K +C  +   +H C+H          C C  G      G RC+R
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)

Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531
           +D+  C+    C   D      C+N   S+ C CP GH L      C   K +  +L   
Sbjct: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407

Query: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572
               +H C+H   +     +C C  G   +  G  C+R         K++C A
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)

Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
           C ++ Y  + KPG     V  +      C +GY    N   C  ++ CA         CL
Sbjct: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371

Query: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511
           N   S+ C C  G  +      C         + + L+S +H C++          C C 
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431

Query: 512 EG 513
            G
Sbjct: 432 VG 433


>gi|19743803 fibulin 5 precursor [Homo sapiens]
          Length = 448

 Score =  171 bits (433), Expect = 3e-42
 Identities = 95/338 (28%), Positives = 156/338 (46%), Gaps = 64/338 (18%)

Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLC------ 344
           LC+  PG+   QC +G+ L     +C+ +D C +    C  +  CVN +G YLC      
Sbjct: 15  LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74

Query: 345 -------------------------------------QCHEGFALNPDKKTCTKIDYCAS 367
                                                 C  G+ ++ +   C  +D CA+
Sbjct: 75  VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECAT 133

Query: 368 SNHGCQ--HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
            +H C     C+NT+  Y+C C  G+ L   +  C  I+ C      C+  C N+  SY 
Sbjct: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYS 189

Query: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
           C C+ G+TL+ +G++C  V+ CA  ++ C Q C+NT  SF+C+C  G+ + ED   CS +
Sbjct: 190 CTCNPGFTLNEDGRSCQDVNECA-TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDM 248

Query: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
           D C  S+  C++ CVN   ++ C CP G++L  D ++C  ++ C   +H C  + +C + 
Sbjct: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308

Query: 544 EDSFVC----QCFEGYILREDGKTCRRKDVCQAIDHGC 577
           +  F C    +C E Y+   D +      +C A + GC
Sbjct: 309 QGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341



 Score =  167 bits (424), Expect = 3e-41
 Identities = 102/334 (30%), Positives = 153/334 (45%), Gaps = 25/334 (7%)

Query: 335 CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC-----HC 387
           C+ + G+   QC  GF L+     C  ID C +    C+ +  CVN +  Y C       
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
            +G   NP   T     Y A   P        +     CR   GY +D + + C  VD C
Sbjct: 76  YRGPYSNP-YSTPYSGPYPAAAPPLSAPNYPTISRPLICRF--GYQMDESNQ-CVDVDEC 131

Query: 448 AQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRS 505
           A   H C   Q+C+NTE  + C C++G+ + E    C  +D C      C+  C N+  S
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGY--CQQLCANVPGS 187

Query: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
           ++C C  G  L  DG++C  ++ CA  ++ C  +CV++  SF+C+C  GY L EDG  C 
Sbjct: 188 YSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCS 246

Query: 566 RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICV 623
             D C   +  C+H CVN   +Y C C  G+ L +D + C+  + C+  +H C  +  C 
Sbjct: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306

Query: 624 NNGNSYIC----KCSEGFVLAEDGRRCKKCTEGP 653
           N    + C    +C E ++   D  RC    E P
Sbjct: 307 NLQGGFKCIDPIRCEEPYLRISD-NRCMCPAENP 339



 Score =  164 bits (415), Expect = 4e-40
 Identities = 96/337 (28%), Positives = 148/337 (43%), Gaps = 64/337 (18%)

Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVC------- 303
           C+  PG+   +C  G+ L+     C   D C      C  + +CVN  G ++C       
Sbjct: 16  CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75

Query: 304 ------------------------------------QCYSGYALAEDGKRCVAVDYCASE 327
                                                C  GY + ++  +CV VD CA++
Sbjct: 76  YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATD 134

Query: 328 NHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC 385
           +H C     C+N +G Y C C +G+ L   +  C  ID C      CQ  C N   SYSC
Sbjct: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYSC 190

Query: 386 HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVD 445
            C  GFTLN D ++C+ +N CA   P C   CVN   S+ CRC  GY L+ +G  CS +D
Sbjct: 191 TCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249

Query: 446 HCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMD 503
            C+  +  C+  C+N   ++ C C  G+++ +D ++C  ++ C   +H C  + +C N+ 
Sbjct: 250 ECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQ 309

Query: 504 RSFAC----QCPEGHVLRSDGKTCAKLDSCALGDHGC 536
             F C    +C E ++  SD +       C   + GC
Sbjct: 310 GGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341



 Score =  153 bits (387), Expect = 6e-37
 Identities = 84/221 (38%), Positives = 110/221 (49%), Gaps = 18/221 (8%)

Query: 242 CSTLEHNC--AHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
           C+T  H C     CIN  G Y C C  GY L   Q  C   D C      C+QLC NVPG
Sbjct: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPG 186

Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
           S+ C C  G+ L EDG+ C  V+ CA+EN  C   CVN  GS++C+C  G+ L  D   C
Sbjct: 187 SYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEEDGVHC 245

Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EHEC 417
           + +D C+ S   CQHECVN   +Y C C  G+ L  D ++C+ IN C      C  +  C
Sbjct: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305

Query: 418 VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGC 454
            N++  + C    RC   Y L  +   C     C  ++ GC
Sbjct: 306 YNLQGGFKCIDPIRCEEPY-LRISDNRCM----CPAENPGC 341



 Score =  135 bits (341), Expect = 1e-31
 Identities = 65/174 (37%), Positives = 86/174 (49%), Gaps = 12/174 (6%)

Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
           C   C N+PGSY C C  G+ LN D  +C+  + CA E+  C Q CVN  GSF+C+C  G
Sbjct: 177 CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPG 235

Query: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
           Y L EDG  C  +D C+     C+HECVN  G+Y C C  G+ L  D ++C  I+ C   
Sbjct: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295

Query: 369 NHGC--QHECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
           NH C  Q  C N    + C     C + +    D +       C    PGC  +
Sbjct: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGCRDQ 344



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)

Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
           C+T E+ C   C+N  GS++CRC  GY L  D   C   D C+  +  C+  CVN PG++
Sbjct: 211 CAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY 269

Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPD 355
            C C  GY L +D + C  ++ C   NH C  +  C N  G + C    +C E +    D
Sbjct: 270 FCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISD 329

Query: 356 KKTCTKIDYCASSNHGCQHE 375
            +       C + N GC+ +
Sbjct: 330 NRC-----MCPAENPGCRDQ 344



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)

Query: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC 631
           +C+ S  +   +C  GF L     +C   D C++    C  + +CVN    Y+C
Sbjct: 15  LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,871,961
Number of Sequences: 37866
Number of extensions: 1882053
Number of successful extensions: 12803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 193
Number of HSP's that attempted gapping in prelim test: 4513
Number of HSP's gapped (non-prelim): 2704
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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