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Search of human proteins with 62548862
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
(937 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 1954 0.0
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 1942 0.0
gi|11321565 matrilin 3 precursor [Homo sapiens] 363 e-100
gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens] 360 4e-99
gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens] 309 9e-84
gi|56237021 fibrillin 3 precursor [Homo sapiens] 290 4e-78
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 277 4e-74
gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens] 276 5e-74
gi|66346695 fibrillin 2 precursor [Homo sapiens] 276 8e-74
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 273 7e-73
gi|10190748 CEGP1 protein [Homo sapiens] 255 1e-67
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 249 6e-66
gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens] 246 5e-65
gi|24430141 fibrillin 1 precursor [Homo sapiens] 245 2e-64
gi|46249414 latent transforming growth factor beta binding prote... 238 2e-62
gi|46249412 latent transforming growth factor beta binding prote... 238 2e-62
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 231 3e-60
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 219 7e-57
gi|4557733 latent transforming growth factor beta binding protei... 218 3e-56
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 207 3e-53
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 207 4e-53
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 206 8e-53
gi|34734066 fibulin 1 isoform D [Homo sapiens] 206 8e-53
gi|110347437 latent transforming growth factor beta binding prot... 193 6e-49
gi|110347412 latent transforming growth factor beta binding prot... 193 6e-49
gi|110347431 latent transforming growth factor beta binding prot... 193 6e-49
gi|118572606 hemicentin 1 [Homo sapiens] 187 3e-47
gi|194328809 latent transforming growth factor beta binding prot... 182 2e-45
gi|18497288 latent transforming growth factor beta binding prote... 176 9e-44
gi|19743803 fibulin 5 precursor [Homo sapiens] 171 3e-42
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 1954 bits (5062), Expect = 0.0
Identities = 937/937 (100%), Positives = 937/937 (100%)
Query: 1 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
Sbjct: 1 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
Query: 61 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
Sbjct: 61 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
Query: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
Sbjct: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
Query: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
Sbjct: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
Query: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
Sbjct: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
Sbjct: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
Sbjct: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
Query: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
Query: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
Sbjct: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
Query: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
Sbjct: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
Query: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE
Sbjct: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
Query: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937
NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
Sbjct: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 1942 bits (5032), Expect = 0.0
Identities = 937/956 (98%), Positives = 937/956 (98%), Gaps = 19/956 (1%)
Query: 1 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF
Sbjct: 1 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 60
Query: 61 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV
Sbjct: 61 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 120
Query: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV
Sbjct: 121 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 180
Query: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH
Sbjct: 181 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 240
Query: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS
Sbjct: 241 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT
Sbjct: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM
Sbjct: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 420
Query: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK
Sbjct: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
Query: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC
Sbjct: 481 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 540
Query: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI
Sbjct: 601 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 660
Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK
Sbjct: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS
Sbjct: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED
Sbjct: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
Query: 841 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH 881
SDGRQDSPAGELPKTVQQPT VQHRYLFEEDNLLRSTQKLSH
Sbjct: 841 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH 900
Query: 882 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 937
STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR
Sbjct: 901 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 956
>gi|11321565 matrilin 3 precursor [Homo sapiens]
Length = 486
Score = 363 bits (932), Expect = e-100
Identities = 196/417 (47%), Positives = 254/417 (60%), Gaps = 26/417 (6%)
Query: 10 LLILGQIVLLPAEA----------RERSRGRSISRGRH------------ARTHPQTALL 47
LL+L ++LLP+ A R +RG S GR + P A
Sbjct: 14 LLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARG 73
Query: 48 ESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKN 107
C+++ DLVFIIDSSRSV ++ KVK F+ I+ LDIGP TRV ++ Y STVK
Sbjct: 74 AGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKI 133
Query: 108 EFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMI 167
EF L+ + K +++AV R+ LSTGTM+GLAIQ A++ AF+ GAR N+P+V +I
Sbjct: 134 EFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAII 193
Query: 168 VTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIET 227
VTDGRPQD V EVAA+A+ +GI ++A+GV + D +LK + SEP E+HVF V + IE
Sbjct: 194 VTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEK 253
Query: 228 LTSVFQKKLCTAHMCSTLEHNCAHFCINI-PGSYVCRCKQGYILNSDQTTCRIQDLCAME 286
L+S FQ+ C C H C H CI+ G + C C QGY LN+D+ TC D CA+
Sbjct: 254 LSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALN 313
Query: 287 DHNCEQLCVN-VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVN-ADGSYLC 344
H CE +CVN GS+ C+CY GY L ED K C A D CA HGC+H CVN GS+ C
Sbjct: 314 THGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHC 373
Query: 345 QCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTC 400
+C+EG+ LN DKKTC+ D CA +HGCQH CV+ SY C C G+TLN DKKTC
Sbjct: 374 ECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTC 430
Score = 172 bits (435), Expect = 2e-42
Identities = 83/199 (41%), Positives = 114/199 (57%), Gaps = 12/199 (6%)
Query: 356 KKTCTKIDYCASSNHGCQHECVNTDDS-YSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
++T +D C H CQH C++ + + C C +G+TLN DKKTC ++ CALN GCE
Sbjct: 259 QETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCE 318
Query: 415 HECVN-MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTE-DSFVCQCSEG 472
H CVN SY+C C+ GYTL+ + KTCS D CA HGC+ +C+N S C+C EG
Sbjct: 319 HICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEG 378
Query: 473 FLINEDLKTCSRVDYCLLSDHGCEYSCVNMD-RSFACQCPEGHVLRSDGKTCAKLDSCAL 531
+ +N D KTCS D C L HGC++ CV+ S+ C C G+ L D KTC+ +
Sbjct: 379 YTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEA-- 436
Query: 532 GDHGCEHSCVSSEDSFVCQ 550
VS+ED+ C+
Sbjct: 437 ------RRLVSTEDACGCE 449
Score = 171 bits (432), Expect = 4e-42
Identities = 79/176 (44%), Positives = 106/176 (60%), Gaps = 4/176 (2%)
Query: 480 KTCSRVDYCLLSDHGCEYSCVNM-DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
+T +D C+L H C++ C++ + C+C +G+ L +D KTC+ LD CAL HGCEH
Sbjct: 260 ETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEH 319
Query: 539 SCVSSED-SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNS-DDSYTCECLEGF 596
CV+ S+ C+C+EGY L ED KTC +D C HGC+HICVN S+ CEC EG+
Sbjct: 320 ICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGY 379
Query: 597 RLAEDGKRCRRKDVCKSTHHGCEHICVNNG-NSYICKCSEGFVLAEDGRRCKKCTE 651
L D K C +D C HGC+HICV++G SY C C G+ L ED + C E
Sbjct: 380 TLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEE 435
Score = 154 bits (389), Expect = 4e-37
Identities = 75/187 (40%), Positives = 121/187 (64%)
Query: 649 CTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFT 708
C P+DLVF+ID S+S+ F VK FV+ IID+L I P RV ++ Y++ V EF
Sbjct: 77 CKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQ 136
Query: 709 LRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTD 768
L+ + + +K+AV + + G+M+GLA++ + +FT GAR S+ +P+ AI+ TD
Sbjct: 137 LQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTD 196
Query: 769 GRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISE 828
GR QD V+E A++A+A+GI +YAVGV +A L+ +ASEP +H+FY E + ++++S
Sbjct: 197 GRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSS 256
Query: 829 KLKKGIC 835
+ ++ C
Sbjct: 257 RFQETFC 263
>gi|13699830 matrilin 4 isoform 1 precursor [Homo sapiens]
Length = 581
Score = 360 bits (923), Expect = 4e-99
Identities = 180/419 (42%), Positives = 250/419 (59%), Gaps = 48/419 (11%)
Query: 516 LRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
L+ + CA +D CA G HGCEH CV+S S+ C C G++L++D ++CR D C +H
Sbjct: 207 LQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNH 265
Query: 576 GCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSE 635
C+H CV++ C C EG L DG+ C+ +D+C HGCE CV+ G SY C C E
Sbjct: 266 SCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPE 325
Query: 636 GFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVG 695
G L DG+ C +C EG +DLV ++DGSKS+ +NFE+VK+FV I+D L +SP+ RVG
Sbjct: 326 GRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVG 385
Query: 696 LLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPL 755
L+Q+S++V TEF L + +A ++K+AV ++YM +G+MTGLAL+HM E SF++ +GARP
Sbjct: 386 LVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPR 445
Query: 756 STRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLF 815
+ VPR +VFTDGR+QDD+S WA++AK GI MYAVGVGKA+E EL+EIASEP H+
Sbjct: 446 ALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVS 505
Query: 816 YAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRS 875
YA DF TM + E L+ IC E+ +
Sbjct: 506 YAPDFGTMTHLLENLRGSIC--------------------------------PEEGISAG 533
Query: 876 TQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRL 934
T E C+CE+L+ FQ + LT L ++T R+E LEN+L
Sbjct: 534 T---------------ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQL 577
Score = 320 bits (821), Expect = 3e-87
Identities = 150/319 (47%), Positives = 210/319 (65%)
Query: 43 QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
Q L C DLVF+IDSSRSV ++ +++F++ +L+ L++GP+ TRVG++QY
Sbjct: 20 QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79
Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
S V++ F L+ F R+ ++ERA++ + L+ GTMTGLAIQYA+N+AFS AEGARP E VP
Sbjct: 80 SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139
Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
RV +IVTDGRPQD VAEVAA+AR GI I+A+GV + D +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199
Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
I+ FQ +LC +C+ H C H C+N PGSY C C+ G++L DQ +CR D
Sbjct: 200 DLIQEFGLQFQSRLCAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDY 259
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSY 342
C+ +H+C+ CV+ PG C C G+ L DG+ C D C +HGCE +CV+ SY
Sbjct: 260 CSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSY 319
Query: 343 LCQCHEGFALNPDKKTCTK 361
C C EG L D K+C +
Sbjct: 320 RCLCPEGRQLQADGKSCNR 338
Score = 169 bits (427), Expect = 1e-41
Identities = 81/188 (43%), Positives = 126/188 (67%)
Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
+C GP+DLVFVID S+S+ FE ++QF+ G++ L + P A RVG++QYS+QV + F
Sbjct: 27 RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86
Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
LR F+ +DM++A+ + + +G+MTGLA+++ +F+ EGARP RVPR A++ T
Sbjct: 87 PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146
Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
DGR QD V+E A++A+A GI +YAVGV +A L+ +AS P ++H+F E F + E
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206
Query: 828 EKLKKGIC 835
+ + +C
Sbjct: 207 LQFQSRLC 214
Score = 155 bits (393), Expect = 1e-37
Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)
Query: 51 CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
C DLV ++D S+SV ++ VK F+ I+ FLD+ P+ TRVGL+Q+ S V+ EF
Sbjct: 339 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 398
Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
L + +EV++AV + ++ GTMTGLA+++ + +FSEA+GARP NVPRV ++ TD
Sbjct: 399 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 458
Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
GR QD ++ AA+A++ GI+++A+GVG+ L+ I SEP E HV +F + L
Sbjct: 459 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 518
Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
+ +C S L C + + LN Q T R++DL
Sbjct: 519 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 573
Score = 142 bits (358), Expect = 1e-33
Identities = 60/127 (47%), Positives = 77/127 (60%)
Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
R A+D CA HGCEH CVN+ GSY C C GF L D+++C IDYC+ NH CQHEC
Sbjct: 212 RLCAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHEC 271
Query: 377 VNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDP 436
V+T CHC +G L PD ++C+ + C GCE +CV+ SY C C G L
Sbjct: 272 VSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQA 331
Query: 437 NGKTCSR 443
+GK+C+R
Sbjct: 332 DGKSCNR 338
Score = 134 bits (336), Expect = 5e-31
Identities = 62/148 (41%), Positives = 82/148 (55%), Gaps = 6/148 (4%)
Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
F L + C ID CA HGC+H CVN+ SY CHC GF L D+++CR I+YC+
Sbjct: 205 FGLQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFG 263
Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
C+HECV+ C C G+ L P+G++C D C DHGCE C++ S+ C C
Sbjct: 264 NHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLC 323
Query: 470 SEGFLINEDLKTCSR-----VDYCLLSD 492
EG + D K+C+R VD LL D
Sbjct: 324 PEGRQLQADGKSCNRCREGHVDLVLLVD 351
Score = 128 bits (322), Expect = 2e-29
Identities = 53/123 (43%), Positives = 74/123 (60%)
Query: 444 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503
+D CA+ HGCE C+N+ S+ C C GF++ +D ++C +DYC +H C++ CV+
Sbjct: 216 IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTP 275
Query: 504 RSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT 563
C C EGH L+ DG++C D C DHGCE CVS S+ C C EG L+ DGK+
Sbjct: 276 GGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKS 335
Query: 564 CRR 566
C R
Sbjct: 336 CNR 338
Score = 120 bits (300), Expect = 8e-27
Identities = 52/136 (38%), Positives = 77/136 (56%), Gaps = 1/136 (0%)
Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
++ F L + C I+ CA GCEH CVN SY+C C G+ L + ++C +D+C
Sbjct: 202 IQEFGLQFQSRLCA-IDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYC 260
Query: 448 AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
+ +H C+ C++T C C EG + D ++C D C DHGCE+ CV+ S+
Sbjct: 261 SFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYR 320
Query: 508 CQCPEGHVLRSDGKTC 523
C CPEG L++DGK+C
Sbjct: 321 CLCPEGRQLQADGKSC 336
>gi|13699834 matrilin 4 isoform 2 precursor [Homo sapiens]
Length = 540
Score = 309 bits (791), Expect = 9e-84
Identities = 157/367 (42%), Positives = 216/367 (58%), Gaps = 47/367 (12%)
Query: 568 DVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGN 627
D C +H C+H CV++ C C EG L DG+ C+ +D+C HGCE CV+ G
Sbjct: 217 DYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGL 276
Query: 628 SYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTI 687
SY C C EG L DG+ C +C EG +DLV ++DGSKS+ +NFE+VK+FV I+D L +
Sbjct: 277 SYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDV 336
Query: 688 SPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFT 747
SP+ RVGL+Q+S++V TEF L + +A ++K+AV ++YM +G+MTGLAL+HM E SF+
Sbjct: 337 SPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFS 396
Query: 748 QGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIAS 807
+ +GARP + VPR +VFTDGR+QDD+S WA++AK GI MYAVGVGKA+E EL+EIAS
Sbjct: 397 EAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIAS 456
Query: 808 EPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLF 867
EP H+ YA DF TM + E L+ IC
Sbjct: 457 EPAELHVSYAPDFGTMTHLLENLRGSIC-------------------------------- 484
Query: 868 EEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRM 927
E+ + T E C+CE+L+ FQ + LT L ++T R+
Sbjct: 485 PEEGISAGT---------------ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARL 529
Query: 928 EALENRL 934
E LEN+L
Sbjct: 530 EDLENQL 536
Score = 269 bits (688), Expect = 8e-72
Identities = 131/276 (47%), Positives = 184/276 (66%)
Query: 43 QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
Q L C DLVF+IDSSRSV ++ +++F++ +L+ L++GP+ TRVG++QY
Sbjct: 20 QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79
Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
S V++ F L+ F R+ ++ERA++ + L+ GTMTGLAIQYA+N+AFS AEGARP E VP
Sbjct: 80 SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139
Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
RV +IVTDGRPQD VAEVAA+AR GI I+A+GV + D +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199
Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
I+ FQ +LC CS H+C H C++ PG C C++G+ L D +C+++DL
Sbjct: 200 DLIQEFGLQFQSRLCAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDL 259
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
C DH CE CV+ S+ C C G L DGK C
Sbjct: 260 CNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 295
Score = 169 bits (427), Expect = 1e-41
Identities = 81/188 (43%), Positives = 126/188 (67%)
Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
+C GP+DLVFVID S+S+ FE ++QF+ G++ L + P A RVG++QYS+QV + F
Sbjct: 27 RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86
Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
LR F+ +DM++A+ + + +G+MTGLA+++ +F+ EGARP RVPR A++ T
Sbjct: 87 PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146
Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
DGR QD V+E A++A+A GI +YAVGV +A L+ +AS P ++H+F E F + E
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206
Query: 828 EKLKKGIC 835
+ + +C
Sbjct: 207 LQFQSRLC 214
Score = 155 bits (393), Expect = 1e-37
Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)
Query: 51 CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
C DLV ++D S+SV ++ VK F+ I+ FLD+ P+ TRVGL+Q+ S V+ EF
Sbjct: 298 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 357
Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
L + +EV++AV + ++ GTMTGLA+++ + +FSEA+GARP NVPRV ++ TD
Sbjct: 358 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 417
Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
GR QD ++ AA+A++ GI+++A+GVG+ L+ I SEP E HV +F + L
Sbjct: 418 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 477
Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
+ +C S L C + + LN Q T R++DL
Sbjct: 478 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 532
Score = 91.3 bits (225), Expect = 4e-18
Identities = 38/86 (44%), Positives = 50/86 (58%)
Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHEC 376
R A+DYC+ NH C+HECV+ G C C EG L PD ++C D C +HGC+ +C
Sbjct: 212 RLCAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQC 271
Query: 377 VNTDDSYSCHCLKGFTLNPDKKTCRR 402
V+ SY C C +G L D K+C R
Sbjct: 272 VSEGLSYRCLCPEGRQLQADGKSCNR 297
Score = 87.8 bits (216), Expect = 4e-17
Identities = 40/94 (42%), Positives = 53/94 (56%), Gaps = 1/94 (1%)
Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
F L + C IDYC+ NH CQHECV+T CHC +G L PD ++C+ + C
Sbjct: 205 FGLQFQSRLCA-IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGV 263
Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR 443
GCE +CV+ SY C C G L +GK+C+R
Sbjct: 264 DHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 297
Score = 85.9 bits (211), Expect = 2e-16
Identities = 37/82 (45%), Positives = 48/82 (58%)
Query: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
+DYC +H C++ CV+ C C EGH L+ DG++C D C DHGCE CVS
Sbjct: 216 IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEG 275
Query: 545 DSFVCQCFEGYILREDGKTCRR 566
S+ C C EG L+ DGK+C R
Sbjct: 276 LSYRCLCPEGRQLQADGKSCNR 297
Score = 79.3 bits (194), Expect = 2e-14
Identities = 32/80 (40%), Positives = 48/80 (60%)
Query: 444 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD 503
+D+C+ +H C+ C++T C C EG + D ++C D C DHGCE+ CV+
Sbjct: 216 IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEG 275
Query: 504 RSFACQCPEGHVLRSDGKTC 523
S+ C CPEG L++DGK+C
Sbjct: 276 LSYRCLCPEGRQLQADGKSC 295
Score = 78.6 bits (192), Expect = 3e-14
Identities = 40/110 (36%), Positives = 57/110 (51%), Gaps = 6/110 (5%)
Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
++ F L + C I+YC+ C+HECV+ C C G+ L P+G++C D C
Sbjct: 202 IQEFGLQFQSRLCA-IDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLC 260
Query: 448 AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-----VDYCLLSD 492
DHGCE C++ S+ C C EG + D K+C+R VD LL D
Sbjct: 261 NGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVD 310
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 290 bits (742), Expect = 4e-78
Identities = 158/429 (36%), Positives = 215/429 (50%), Gaps = 25/429 (5%)
Query: 242 CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
C C H C N GS+ C C G+ L++ + C D C + C Q CVN PG
Sbjct: 990 CKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPG 1049
Query: 300 SFVCQCYSGYALAEDG----KRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNP 354
SF C+C+ GY E G K C+ VD CA + C C N DGSY CQC G L
Sbjct: 1050 SFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTA 1106
Query: 355 DKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
C ID C+ S+ C H +CVN ++ C C GF PD++ C IN C + GC
Sbjct: 1107 KGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGC 1166
Query: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEG 472
+ C+N E SY C C +GY+L P+G+ C+ VD C + C+Q C N C C +G
Sbjct: 1167 DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDG 1226
Query: 473 FLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCAL 531
F+ D++TC VD C L+ H C + C N SF C C G+++R C+ +D C +
Sbjct: 1227 FMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEV 1286
Query: 532 GDHGCEH--SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDS 587
G H C+ SC++ SF C+C G++ DG C D C + +H C C+N S
Sbjct: 1287 GGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGS 1344
Query: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646
Y C C +GF A DG C +D C C++ C+N Y C+C GF ED R C
Sbjct: 1345 YRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRAC 1402
Query: 647 K---KCTEG 652
+ +C +G
Sbjct: 1403 QDVDECAQG 1411
Score = 216 bits (551), Expect = 6e-56
Identities = 136/447 (30%), Positives = 184/447 (41%), Gaps = 40/447 (8%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVP 298
CS CA C N GSY+C C GY L D CR D CA +C C N+
Sbjct: 2170 CSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
Query: 299 GSFVCQCYSGYA-LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDK 356
G+F C C G L G+ C + C ++ C + CVN GS+ C C EGF +P
Sbjct: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2289
Query: 357 KTCTKIDYCASSNHGCQHECVNTDDSYS------CHCLKGFTLNPDKKTC---------- 400
C I Q C + S C C G P + C
Sbjct: 2290 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRK 2349
Query: 401 ------------RRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
R ++ C + C H EC+N S+ C C GYT D TC +D C
Sbjct: 2350 LCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC 2409
Query: 448 AQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFA 507
+Q C LC NT+ SF+C C G+L+ ED +TC +D C H C++ CVN +F
Sbjct: 2410 SQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFT 2469
Query: 508 CQCPEGHVLRSDGKTCAKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
C+CP G + C D C+ G G C ++ SF C+C +G+ L G C
Sbjct: 2470 CRCPPG--FTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE 2527
Query: 566 RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVN 624
+ C H C+H C N Y C C +GF +C ++ C + C C N
Sbjct: 2528 DVNECDG-PHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRN 2586
Query: 625 NGNSYICKCSEGFVLAEDGRRCKKCTE 651
+ C C GF + C++ E
Sbjct: 2587 TLGGFRCVCPSGFDFDQALGGCQEVDE 2613
Score = 205 bits (521), Expect = 2e-52
Identities = 131/421 (31%), Positives = 189/421 (44%), Gaps = 33/421 (7%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVP 298
C H C H C N GS+VC C+ GY++ T C D C + HNC+ C+N+P
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
Query: 299 GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDK 356
GSF C+C G+ DG C +D C S+ H C +C+N GSY C C +GFA D
Sbjct: 1302 GSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFA--GDG 1357
Query: 357 KTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH 415
C D CA + C + +C+N Y C C GF D + C+ ++ CA
Sbjct: 1358 FFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFG 1417
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
C N+ + C C+ GY LD G C+ ++ CA + +C+NT S++C C + F +
Sbjct: 1418 SCENLPGMFRCICNGGYELDRGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFEL 1477
Query: 476 NEDLKTC--SRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG- 532
N C +R C L H D +C G G T A C+LG
Sbjct: 1478 NPSGVGCVDTRAGNCFLETHD------RGDSGISCSAEIG-----VGVTRASC-CCSLGR 1525
Query: 533 --DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV--CQAIDHGCE-HICVNSDDS 587
+ CE +++ + C G + + T +D+ CQ + C+ CVN+ S
Sbjct: 1526 AWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGS 1585
Query: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAEDGRR 645
+ CEC G+ L+E + C D C STH G C N +Y C C ++ G
Sbjct: 1586 FQCECPPGYHLSEHTRICEDIDEC-STHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNN 1644
Query: 646 C 646
C
Sbjct: 1645 C 1645
Score = 201 bits (511), Expect = 3e-51
Identities = 132/454 (29%), Positives = 184/454 (40%), Gaps = 48/454 (10%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGS 300
C C CIN GSY C C QGY L D C D C C+Q C N+PG
Sbjct: 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGG 1218
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
C CY G+ D + CV VD C H C H +C N GS++C C G+ + C
Sbjct: 1219 HRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGC 1278
Query: 360 TKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-- 415
+ +D C H C C+N S+SC CL G+ D C ++ C + C
Sbjct: 1279 SDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWV--GDGFECHDLDECVSQEHRCSPRG 1336
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474
+C+N+ SY C C +G+ D G C D CA+ C+ CLN + C+C GF
Sbjct: 1337 DCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFD 1394
Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
ED + C VD C + SC N+ F C C G+ L G C ++ CA +
Sbjct: 1395 PTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECADPVN 1454
Query: 535 GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564
C+++ S++C C + + L G C
Sbjct: 1455 CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGV 1514
Query: 565 RRKDVC----QAIDHGCEHICVNSDDSYTCECL--EGFRLAEDGKRCRRKDVCKSTHHGC 618
R C +A + CE + + Y C EGF+ D C+ C
Sbjct: 1515 TRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC 1574
Query: 619 EH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
+ CVN S+ C+C G+ L+E R C+ E
Sbjct: 1575 QGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE 1608
Score = 198 bits (503), Expect = 2e-50
Identities = 130/408 (31%), Positives = 173/408 (42%), Gaps = 43/408 (10%)
Query: 281 DLCAMEDHNC-EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNA 338
D+C + C C+ P S+ C+C GY G+ C+ VD C S C H +CVN
Sbjct: 410 DICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSP--CHHGDCVNI 466
Query: 339 DGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQ-HECVNTDDSYSCHCLKGFTLNPDK 397
G+Y C+C+ GF P ++ C +D C S C CVNT+ S+ C C GF L+PD
Sbjct: 467 PGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDG 526
Query: 398 KTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL 457
K C N CA + C+N + S+ C C G+ L P G C +D C
Sbjct: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
Query: 458 CLNTEDSFVCQCSEGFLINEDLKTC-----SRVDYCLLSDHGC-----------EYSCVN 501
C NTE SF CQC G + D + C Y + C E C N
Sbjct: 587 CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
Query: 502 MDRSFA--CQ-------------CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSED 545
D F CQ C G + +DG+ ++ CAL C + C +
Sbjct: 647 PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGR---DINECALDPEVCANGVCENLRG 703
Query: 546 SFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKR 604
S+ C C GY GK C D C C++ C NS SY+C C GF +D +
Sbjct: 704 SYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 763
Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
C+ D C S+ +C N SY CKC G L G C T+G
Sbjct: 764 CKDVDECLSS-PCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKG 810
Score = 197 bits (500), Expect = 5e-50
Identities = 110/314 (35%), Positives = 142/314 (45%), Gaps = 8/314 (2%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
C L H CAH CIN GS+ C C+ GY ++ TTC D C+ C LC N GS
Sbjct: 2367 CRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGS 2426
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
F+C C GY L EDG+ C +D C S H C+ CVN G++ C+C GF + + C
Sbjct: 2427 FLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQH--HQACF 2484
Query: 361 KIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
D C++ C C NT S+ C C +GFTL C +N C C+H C
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD-GPHRCQHGCQ 2543
Query: 419 NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQL-CLNTEDSFVCQCSEGFLINE 477
N Y C C +G+T C + CA C C NT F C C GF ++
Sbjct: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQ 2603
Query: 478 DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-SCALGDHGC 536
L C VD C C YSC N F C CP+G+ G + L S D
Sbjct: 2604 ALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQDTPD 2663
Query: 537 EHSCVSSEDSFVCQ 550
+ +SSE + C+
Sbjct: 2664 KEELLSSEACYECK 2677
Score = 191 bits (485), Expect = 3e-48
Identities = 148/515 (28%), Positives = 201/515 (39%), Gaps = 95/515 (18%)
Query: 228 LTSVFQKKLCTAHMCSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME 286
LT + K C + CA+ CIN GS+ C C G+ NS C D C
Sbjct: 1711 LTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSR 1770
Query: 287 DHNCEQL--CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYL 343
+ C+Q C+N+PGS+ C+C GY L+ G CV + C + C H +C++ +GSY+
Sbjct: 1771 ESPCQQNADCINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYM 1829
Query: 344 CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI 403
C CH GF + D+ C ID C G C N SY+C C GF + C
Sbjct: 1830 CLCHRGFQASADQTLCMDIDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVT-HNGDCVDF 1887
Query: 404 NYC-ALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLN 460
+ C L C C+N S++C C G+ L +GK C + C C C N
Sbjct: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQN 1947
Query: 461 TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSD 519
E SF C C GF + D C +D C + C + +C N SF C CP G VL +
Sbjct: 1948 LEGSFRCICPPGFQVQSD--HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDN 2005
Query: 520 GKTC-------------------------AKLDSCALGDHG------CEHSCVSSEDSF- 547
G C K C G CE +F
Sbjct: 2006 GHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQ 2065
Query: 548 -VCQCFEGYILREDGKTCRRKDVCQAIDHG--CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
+C G + G R+DV + ++ C + +CVN+D S+ CEC G+ L G
Sbjct: 2066 ELCPFGHGAV---PGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGI 2122
Query: 604 RCRRKDVCKSTH---------------------------HGCEHI-------------CV 623
C D C H CE I C
Sbjct: 2123 NCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCH 2182
Query: 624 NNGNSYICKCSEGFVLAEDGRRCK---KCTEGPID 655
N SY+C C G+ L EDG C+ +C +G D
Sbjct: 2183 NTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQD 2217
Score = 189 bits (481), Expect = 8e-48
Identities = 137/455 (30%), Positives = 188/455 (41%), Gaps = 63/455 (13%)
Query: 249 CAHF--------CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
C HF C+ P SY C C GY + + + + H+ + CVN+PG+
Sbjct: 412 CRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD--CVNIPGT 469
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTC 359
+ C+CY G+ + CV VD C C CVN +GS+ C C+ GF L+PD K C
Sbjct: 470 YHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC 529
Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
+ CA+S C+N D S+SC C GF L P C I+ C C N
Sbjct: 530 VDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTN 589
Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDH-----------------------------CAQQ 450
E S+ C+C G + +G+ C VD CA
Sbjct: 590 TEGSFRCQCLGGLAVGTDGRVC--VDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANP 647
Query: 451 DHG----CEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRS 505
DHG C+ F CS G I D + ++ C L C C N+ S
Sbjct: 648 DHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRD---INECALDPEVCANGVCENLRGS 704
Query: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC 564
+ C C G+ + GK C +D CAL C++ C +S S+ C C G+ +D + C
Sbjct: 705 YRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEIC 764
Query: 565 RRKDVCQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC--KSTHHGCE 619
KDV + + C +C N SYTC+C G RL G C K C K CE
Sbjct: 765 --KDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCE 822
Query: 620 HICVN-NGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
VN G S +C + A G C++C P
Sbjct: 823 ---VNLQGASLRSECC-ATLGAAWGSPCERCEIDP 853
Score = 184 bits (467), Expect = 3e-46
Identities = 118/402 (29%), Positives = 168/402 (41%), Gaps = 47/402 (11%)
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHEC-VNADGSY---LCQCHEG 349
CVN GSF C+C G L G+ CV V E EC V G Y +C C G
Sbjct: 885 CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG 944
Query: 350 FALNPDKKTC---TKIDYCASSNHG---------------------------CQH-ECVN 378
+ + C +++ + G C H C N
Sbjct: 945 AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRN 1004
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPN 437
T S+ C C GF L+ ++ C I+ C ++ C + CVN S+ C C GY +
Sbjct: 1005 TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGY---ES 1061
Query: 438 G----KTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD 492
G K C VD CA+ C C NT+ S+ CQC G + C +D C LSD
Sbjct: 1062 GFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSD 1121
Query: 493 HGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
C + CVN+ +F C C G D + C ++ C + + GC+ C+++E S+ C C
Sbjct: 1122 GLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSC 1181
Query: 552 FEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDV 610
+GY L DG+ C D C+ C+ C N + C C +GF D + C D
Sbjct: 1182 GQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241
Query: 611 CKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
C H C H C N S++C C G+++ + C E
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDE 1283
Score = 180 bits (457), Expect = 5e-45
Identities = 139/497 (27%), Positives = 196/497 (39%), Gaps = 91/497 (18%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMED------------- 287
C + + C+H C++ GSY+C C +G+ ++DQT C D C +
Sbjct: 1809 CREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSY 1868
Query: 288 -----------HN--------CEQL---------CVNVPGSFVCQCYSGYALAEDGKRCV 319
HN C L C+N GSF C C G+ L DGK CV
Sbjct: 1869 NCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV 1928
Query: 320 AVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECV 377
+ C S C C N +GS+ C C GF + D C ID C+ + C C
Sbjct: 1929 DTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCT 1986
Query: 378 NTDDSYSCHCLKGFTLNPDKKTC-------------------------RRINYCALNKPG 412
N+ S+ C C GF L+ + C + C +PG
Sbjct: 1987 NSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPG 2046
Query: 413 ------CEHECVNMEESYYCRCHRGYTLDPNGKTCSR--VDHCAQQDHGCEQ-LCLNTED 463
CE ++ C G+ P G SR V+ CA+ C +C+NT+
Sbjct: 2047 EGWGDPCELCPQEGSAAFQELCPFGHGAVP-GPDDSREDVNECAENPGVCTNGVCVNTDG 2105
Query: 464 SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDG--K 521
SF C+C G+ ++ C D C + + +C N+ F C C +G G
Sbjct: 2106 SFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGF---EPGLMM 2162
Query: 522 TCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI- 580
TC +D C+L C C ++E S++C C GY LREDG CR D C C
Sbjct: 2163 TCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARG 2222
Query: 581 --CVNSDDSYTCECLEGFR-LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEG 636
C N ++ C C G R L G+ C + C + C + CVN S+ C C EG
Sbjct: 2223 MECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEG 2282
Query: 637 FVLAEDGRRCKKCTEGP 653
F + C +GP
Sbjct: 2283 FQPSPTLTECHDIRQGP 2299
Score = 167 bits (424), Expect = 3e-41
Identities = 133/475 (28%), Positives = 189/475 (39%), Gaps = 82/475 (17%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
+C N PGSY C C G+ D C+ D C + +C N+ GS+ C+C G L
Sbjct: 739 WCQNSPGSYSCSCPPGFHFWQDTEICKDVDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRL 797
Query: 312 AEDGKRCV----AVDYCASENHGCEHECVNADGSYL---------------CQ------- 345
G C+ + + CE VN G+ L C+
Sbjct: 798 DPSGTFCLDSTKGTCWLKIQESRCE---VNLQGASLRSECCATLGAAWGSPCERCEIDPA 854
Query: 346 CHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRI- 403
C GFA TC ++ C S C + CVNT S+ C C +G L+ + C +
Sbjct: 855 CARGFA-RMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVR 913
Query: 404 ----------NYCALNKPG------------------CEHECVNMEE-SYYCRCHRGYTL 434
+ C + PG CE C + E + C RG
Sbjct: 914 LEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-ACPDPESLEFASLCPRGLGF 972
Query: 435 DPNGKTCSR-----VDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC 488
R V+ C C C NT SF C C+ GF ++ + C+ +D C
Sbjct: 973 ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDEC 1032
Query: 489 LLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDG----KTCAKLDSCALGDHGCE-HSCVS 542
+S C + +CVN SF C+C G+ G K C +D CA C +C +
Sbjct: 1033 RISPDLCGQGTCVNTPGSFECECFPGY---ESGFMLMKNCMDVDECARDPLLCRGGTCTN 1089
Query: 543 SEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAED 601
++ S+ CQC G+ L G C D C D C H CVN ++ C C GF+ D
Sbjct: 1090 TDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPD 1149
Query: 602 GKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC---KKCTEGP 653
+ C + C+ + GC+ C+N SY C C +G+ L DGR C +C E P
Sbjct: 1150 RQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
Score = 157 bits (398), Expect = 3e-38
Identities = 120/406 (29%), Positives = 171/406 (42%), Gaps = 47/406 (11%)
Query: 242 CSTLEHNCAH-FCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHN--CE-QLCVN 296
CST C C N G+Y C C Y+ +N ++ +N C+ +L N
Sbjct: 1609 CSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFN 1668
Query: 297 VPGSFVCQCYS-GYALAEDGKRC---VAVDY---CASENHG------------------- 330
V C Y+ G A + C ++ DY C ++ G
Sbjct: 1669 VTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEI 1728
Query: 331 ---CEHE-CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH--ECVNTDDSYS 384
C + C+N GS+ C+C GF N C +D C S CQ +C+N SY
Sbjct: 1729 PAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYR 1788
Query: 385 CHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR 443
C C +G+ L+P C N C C H +C++ E SY C CHRG+ + C
Sbjct: 1789 CKCTRGYKLSPG-GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMD 1847
Query: 444 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYS-CVN 501
+D C +Q G C N S+ C C GF++ + C D C L C + C+N
Sbjct: 1848 IDECDRQPCG-NGTCKNIIGSYNCLCFPGFVVTHN-GDCVDFDECTTLVGQVCRFGHCLN 1905
Query: 502 MDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILRED 560
SF C C +G L +DGK C + C +L +C + E SF C C G+ ++ D
Sbjct: 1906 TAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSD 1965
Query: 561 GKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
C D C + C C NS S+ C C GF L+++G RC
Sbjct: 1966 --HCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
Score = 150 bits (379), Expect = 5e-36
Identities = 146/556 (26%), Positives = 205/556 (36%), Gaps = 138/556 (24%)
Query: 235 KLCTAHM-CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293
K C H C+T C+N GS+ C CK G++L C D C
Sbjct: 527 KNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGH 586
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCV----------AVD-----------------YCAS 326
C N GSF CQC G A+ DG+ CV A++ CA+
Sbjct: 587 CTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCAN 646
Query: 327 ENHG----CE---------------------------HECV------------NADGSYL 343
+HG C+ +EC N GSY
Sbjct: 647 PDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYR 706
Query: 344 CQCHEGFALNPDKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRR 402
C C+ G+ K CT +D CA ++ C + C N+ SYSC C GF D + C+
Sbjct: 707 CVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKD 766
Query: 403 INYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC--SRVDHC--AQQDHGCE--- 455
++ C L+ P C N+ SY C+C G LDP+G C S C Q+ CE
Sbjct: 767 VDEC-LSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNL 825
Query: 456 -------QLC--LNTEDSFVCQ-------CSEGFLINEDLKTCSRVDYCLLSDHGCEYS- 498
+ C L C+ C+ GF + TC V+ C C
Sbjct: 826 QGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGV-TCDDVNECESFPGVCPNGR 884
Query: 499 CVNMDRSFACQCPEGHVLRSDGKTC--AKLDSCAL--GDHGCEHSCVSSEDSFVCQCFEG 554
CVN SF C+CPEG +L + G+ C +L+ C L + C + VC C G
Sbjct: 885 CVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIG 944
Query: 555 YILREDGKTCR----------------------------RKDV--CQAIDHGCEH-ICVN 583
+ + + C KDV C+ C H C N
Sbjct: 945 AVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRN 1004
Query: 584 SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC----SEGFV 638
+ S+ C C GF L + C D C+ + C + CVN S+ C+C GF+
Sbjct: 1005 TVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFM 1064
Query: 639 LAEDGRRCKKCTEGPI 654
L ++ +C P+
Sbjct: 1065 LMKNCMDVDECARDPL 1080
Score = 150 bits (378), Expect = 7e-36
Identities = 115/436 (26%), Positives = 163/436 (37%), Gaps = 57/436 (13%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C+N PG Y C C+ G+ D C+ D CA + C N+PG F C C GY L
Sbjct: 1378 CLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELD 1437
Query: 313 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYCASSNH 370
G C ++ CA + C+N GSYLC C + F LNP C T+ C H
Sbjct: 1438 RGGGNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETH 1497
Query: 371 GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKP---GCEHECVNMEESYYCR 427
D SC G + + +C C+L + CE + Y
Sbjct: 1498 D------RGDSGISCSAEIG--VGVTRASC----CCSLGRAWGNPCELCPMANTTEYRTL 1545
Query: 428 CHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C G PN T +D C + C+ C+NT SF C+C G+ ++E + C
Sbjct: 1546 CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICED 1605
Query: 485 VDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH---GCEHSC 540
+D C C +C N ++ C CP ++ + G C + H C++
Sbjct: 1606 IDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNEL 1665
Query: 541 VSSEDSFVCQCFE--GYILREDGKTCRRK----------------------------DVC 570
+ +C C G + C D C
Sbjct: 1666 AFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDEC 1725
Query: 571 QAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICVNNGN 627
I C + IC+N S+ CEC GF C D C S C+ C+N
Sbjct: 1726 GEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPG 1785
Query: 628 SYICKCSEGFVLAEDG 643
SY CKC+ G+ L+ G
Sbjct: 1786 SYRCKCTRGYKLSPGG 1801
Score = 137 bits (344), Expect = 6e-32
Identities = 123/470 (26%), Positives = 170/470 (36%), Gaps = 91/470 (19%)
Query: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
C++G+I N C+ D C C+ CVN+ GSF C+C G+ L++ C D
Sbjct: 232 CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC--ED 289
Query: 323 Y----CASENHG--CEHECVNADGSYLCQCHEG--FALNPDKKTCTKIDYCASSNHGCQH 374
Y C S G C + C C G +A P + C ++ Q
Sbjct: 290 YRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP-----PRGSNEFQQ 344
Query: 375 ECVNTDDSYSCH-----CLKGF------------TLNPDKKTCR----------RINYCA 407
C H L GF LNP R I
Sbjct: 345 LCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTAT 404
Query: 408 LNK--PGCEH--------ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGCE 455
LN+ C H C+ SY C C+ GYT D G+ C VD C HG
Sbjct: 405 LNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGE-CIDVDECTSSPCHHGD- 462
Query: 456 QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGH 514
C+N ++ C+C GF + C VD C++S C CVN + SF C C G
Sbjct: 463 --CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGF 520
Query: 515 VLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAID 574
L DGK C + CA C++ + SF C C G++L G C D CQ
Sbjct: 521 ELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPG 580
Query: 575 HGCEHICVNSDDSYTCECLEGFRLAEDGKRC---------------------------RR 607
C N++ S+ C+CL G + DG+ C +
Sbjct: 581 ICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKS 640
Query: 608 KDVCKSTHHG----CEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
+ C + HG C+ + + CS G + DGR +C P
Sbjct: 641 ECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDP 690
Score = 136 bits (343), Expect = 8e-32
Identities = 91/336 (27%), Positives = 135/336 (40%), Gaps = 41/336 (12%)
Query: 362 IDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVN 419
ID C + C + C+ T SY C C G+T + + C ++ C + C H +CVN
Sbjct: 409 IDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDV-RGECIDVDECTSSP--CHHGDCVN 465
Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINED 478
+ +Y+CRC+ G+ P + C VD C C C+NTE SF C C+ GF ++ D
Sbjct: 466 IPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPD 525
Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
K C + C S C+N D SF+C C G +L G C +D C
Sbjct: 526 GKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNG 585
Query: 539 SCVSSEDSFVCQCFEGYILREDGKTC---------------------------RRKDVCQ 571
C ++E SF CQC G + DG+ C + + C
Sbjct: 586 HCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCA 645
Query: 572 AIDHG----CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNG 626
DHG C+ + C G + DG+ C C + +C N
Sbjct: 646 NPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINE---CALDPEVCANGVCENLR 702
Query: 627 NSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDG 662
SY C C+ G+ G+ C E ++ + +G
Sbjct: 703 GSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNG 738
Score = 113 bits (283), Expect = 7e-25
Identities = 105/409 (25%), Positives = 154/409 (37%), Gaps = 63/409 (15%)
Query: 281 DLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
+LC + H C + F+ ++G C VD C + C+ CVN
Sbjct: 223 ELCPAQPHPCRR-------GFIPNIHTG--------ACQDVDECQAVPGLCQGGSCVNMV 267
Query: 340 GSYLCQCHEGFALNPDKKTCT--KIDYCASSNHG--CQHECVNTDDSYSCHCLKG--FTL 393
GS+ C+C G L+ C + C S G C + C C +G +
Sbjct: 268 GSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAA 327
Query: 394 NPDKKTC--RRIN----YCAL------NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
P + C R N CA PG + + L+P+G
Sbjct: 328 GPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDA 387
Query: 442 -------------------SRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLINEDLK- 480
+D C + C CL T S+ C+C+ G+ +D++
Sbjct: 388 RGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY--TQDVRG 445
Query: 481 TCSRVDYCLLS--DHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE- 537
C VD C S HG CVN+ ++ C+C G + C +D C + C
Sbjct: 446 ECIDVDECTSSPCHHG---DCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHL 502
Query: 538 HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFR 597
CV++E SF C C G+ L DGK C + C +C+N D S++C C GF
Sbjct: 503 GRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFL 562
Query: 598 LAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
LA G C D C++ C N S+ C+C G + DGR C
Sbjct: 563 LAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVC 611
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/211 (28%), Positives = 74/211 (35%), Gaps = 46/211 (21%)
Query: 346 CHEGFALNPDKKTC---TKIDYCA-SSNHGCQHECVN--TDDSYSCHCLKGFTLNPDKKT 399
C EGF P+ TC T C S GC C+N T SC C KG+T
Sbjct: 90 CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT----- 144
Query: 400 CRRINYCALNKPGCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQ--DHGC 454
+P C+ C N C C G+ + P + R C Q GC
Sbjct: 145 -------VCGQPICDRGCHNGGRCIGPNRCACVYGF-MGPQCERDYRTGPCFGQVGPEGC 196
Query: 455 EQ----------LCLNTED---SFVCQ--------CSEGFLINEDLKTCSRVDYCLLSDH 493
+ LC T C+ C GF+ N C VD C
Sbjct: 197 QHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPG 256
Query: 494 GCEY-SCVNMDRSFACQCPEGHVLRSDGKTC 523
C+ SCVNM SF C+CP GH L C
Sbjct: 257 LCQGGSCVNMVGSFHCRCPVGHRLSDSSAAC 287
Score = 49.3 bits (116), Expect = 2e-05
Identities = 66/265 (24%), Positives = 92/265 (34%), Gaps = 47/265 (17%)
Query: 387 CLKGFTLNPDKKTCRRINY---CALNK-PGCEHECVNME--ESYYCRCHRGYTLDPNGKT 440
C +GF P+ TC C +++ GC C+N C C +GYT G
Sbjct: 90 CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
Query: 441 CSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL--LSDHGCE 496
C + C D GC C+ C C GF+ + R C + GC+
Sbjct: 146 CGQ-PIC---DRGCHNGGRCIGPNR---CACVYGFM-GPQCERDYRTGPCFGQVGPEGCQ 197
Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYI 556
+ + + A C V R+ G C + C H C G+I
Sbjct: 198 HQLTGLVCTKALCCAT--VGRAWGLPC---ELCPAQPHPCRR---------------GFI 237
Query: 557 LREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR--RKDVCKS 613
C+ D CQA+ C+ CVN S+ C C G RL++ C R C S
Sbjct: 238 PNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFS 297
Query: 614 THHG--CEHICVNNGNSYICKCSEG 636
G C + C C G
Sbjct: 298 VLFGGRCAGDLAGHYTRRQCCCDRG 322
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/219 (25%), Positives = 81/219 (36%), Gaps = 50/219 (22%)
Query: 469 CSEGFLINEDLKTCSR---VDYCLLS-DHGCEYSCVNMD--RSFACQCPEGHVLRSDGKT 522
C EGF +L TC+ C +S GC SC+N R +C C +G+ G
Sbjct: 90 CGEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYT----GTV 145
Query: 523 CAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRK---DVC--QAIDH 575
C + + D GC + C+ C C G++ G C R C Q
Sbjct: 146 CGQ----PICDRGCHNGGRCIGPNR---CACVYGFM----GPQCERDYRTGPCFGQVGPE 194
Query: 576 GCEH-----ICVNSDDSYT--------CE--------CLEGFRLAEDGKRCRRKDVCKST 614
GC+H +C + T CE C GF C+ D C++
Sbjct: 195 GCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAV 254
Query: 615 HHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
C+ CVN S+ C+C G L++ C+ G
Sbjct: 255 PGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAG 293
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 277 bits (708), Expect = 4e-74
Identities = 140/369 (37%), Positives = 193/369 (52%), Gaps = 17/369 (4%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN--CEQLCVNVPGSFVCQCYSGYA 310
C N P SY C CK GY + C D C + +N C C+N+PG++ C C+ G+
Sbjct: 50 CQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFM 107
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCA 366
LA DG C+ VD C N GC+ CVNA GSY CQCH GF L+ ++ TC C
Sbjct: 108 LAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCM 167
Query: 367 SSNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
+ +HGC H C T +C C GF L ++K C C GC+H C + +
Sbjct: 168 NKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSCEDTDTGPT 225
Query: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
C CH+ Y L +G+TC ++ CA + GC++ C +T C C GF + D KTC +
Sbjct: 226 CGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDI 283
Query: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSED 545
+ CL+++ GC++ C N SF C C +G+ L +D +TC +D C+ + C+H C++S
Sbjct: 284 NECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSF-ERTCDHICINSPG 342
Query: 546 SFVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
SF C C GYIL G T C D C + C+ CVN+ SY C C G RL +GK
Sbjct: 343 SFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKD 400
Query: 605 CRRKDVCKS 613
C C S
Sbjct: 401 CVETGKCLS 409
Score = 254 bits (649), Expect = 3e-67
Identities = 129/368 (35%), Positives = 189/368 (51%), Gaps = 15/368 (4%)
Query: 286 EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE--NHGCEHECVNADGSYL 343
+D + + +C N P S+ C C GY +GK+C +D C ++ N GC HEC+N G+Y
Sbjct: 42 DDCHIDAICQNTPKSYKCLCKPGYK--GEGKQCEDIDECENDYYNGGCVHECINIPGNYR 99
Query: 344 CQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-RR 402
C C +GF L D C +D C +N GCQ CVN SY C C GF L+ ++ TC R
Sbjct: 100 CTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHR 159
Query: 403 INY---CALNKPGCEHECVNMEES-YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC 458
N C GC H C + C C G+ L N K C+ C + GC+ C
Sbjct: 160 SNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT--CNYGNGGCQHSC 217
Query: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518
+T+ C C + + ++ D +TC ++ C +++ GC+ +C + C CP G L+
Sbjct: 218 EDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQP 275
Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE 578
DGKTC ++ C + + GC+H C ++ SF C C +GY L D +TC+ D C + + C+
Sbjct: 276 DGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC-SFERTCD 334
Query: 579 HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFV 638
HIC+NS S+ C C G+ L C D C ++ C+ CVN SY C C G
Sbjct: 335 HICINSPGSFQCLCHRGYILYGT-THCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRR 393
Query: 639 LAEDGRRC 646
L +G+ C
Sbjct: 394 LHWNGKDC 401
Score = 250 bits (639), Expect = 4e-66
Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 13/328 (3%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
C H CINIPG+Y C C G++L D C D C + C+Q+CVN GS+ CQC+SG
Sbjct: 87 CVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146
Query: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
+ L+++ C+ C +++HGC H C G C C GF L ++K CT
Sbjct: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLT- 205
Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
C N GCQH C +TD +C C + + L+ D +TC I CA+N GC+ C +
Sbjct: 206 -CNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATG 262
Query: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
C C G+TL P+GKTC ++ C + GC+ C NT SF C C +G+ + D +TC
Sbjct: 263 VRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQ 322
Query: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSCVS 542
+D C + C++ C+N SF C C G++L G T C +D C++ + C+ CV+
Sbjct: 323 DIDECSF-ERTCDHICINSPGSFQCLCHRGYILY--GTTHCGDVDECSMSNGSCDQGCVN 379
Query: 543 SEDSFVCQCFEGYILREDGKTCRRKDVC 570
++ S+ C C G L +GK C C
Sbjct: 380 TKGSYECVCPPGRRLHWNGKDCVETGKC 407
Score = 201 bits (510), Expect = 3e-51
Identities = 100/299 (33%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPGCEHEC 417
+D C+ C + C NT SY C C G+ + K C I+ C + GC HEC
Sbjct: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGY--KGEGKQCEDIDECENDYYNGGCVHEC 91
Query: 418 VNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINE 477
+N+ +Y C C G+ L +G C VD C + GC+Q+C+N S+ CQC GF +++
Sbjct: 92 INIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSD 151
Query: 478 DLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDSCALG 532
+ TC C+ DHGC + C + AC C G L + K C +C G
Sbjct: 152 NQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTL--TCNYG 209
Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
+ GC+HSC ++ C C + Y L DG+TC + C + GC+ C ++ C C
Sbjct: 210 NGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCI--ETCAVNNGGCDRTCKDTATGVRCSC 267
Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
GF L DGK C+ + C + GC+H C N S+ C C +G+ L D R C+ E
Sbjct: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDE 326
>gi|13699836 matrilin 4 isoform 3 precursor [Homo sapiens]
Length = 499
Score = 276 bits (707), Expect = 5e-74
Identities = 146/344 (42%), Positives = 202/344 (58%), Gaps = 48/344 (13%)
Query: 591 ECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
+ ++ F L + C R D+C HGCE CV+ G SY C C EG L DG+ C +C
Sbjct: 200 DLIQEFGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCR 258
Query: 651 EGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLR 710
EG +DLV ++DGSKS+ +NFE+VK+FV I+D L +SP+ RVGL+Q+S++V TEF L
Sbjct: 259 EGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLG 318
Query: 711 NFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGR 770
+ +A ++K+AV ++YM +G+MTGLAL+HM E SF++ +GARP + VPR +VFTDGR
Sbjct: 319 RYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGR 378
Query: 771 AQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKL 830
+QDD+S WA++AK GI MYAVGVGKA+E EL+EIASEP H+ YA DF TM + E L
Sbjct: 379 SQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENL 438
Query: 831 KKGICEALEDSDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPL 890
+ IC E+ + T
Sbjct: 439 RGSIC--------------------------------PEEGISAGT-------------- 452
Query: 891 EEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRL 934
E C+CE+L+ FQ + LT L ++T R+E LEN+L
Sbjct: 453 -ELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQL 495
Score = 227 bits (578), Expect = 4e-59
Identities = 111/235 (47%), Positives = 161/235 (68%)
Query: 43 QTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYG 102
Q L C DLVF+IDSSRSV ++ +++F++ +L+ L++GP+ TRVG++QY
Sbjct: 20 QLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYS 79
Query: 103 STVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVP 162
S V++ F L+ F R+ ++ERA++ + L+ GTMTGLAIQYA+N+AFS AEGARP E VP
Sbjct: 80 SQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVP 139
Query: 163 RVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANF 222
RV +IVTDGRPQD VAEVAA+AR GI I+A+GV + D +L+++ S P ++HVFLV +F
Sbjct: 140 RVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESF 199
Query: 223 SQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC 277
I+ FQ +LC +C+ ++H C C++ SY C C +G L +D +C
Sbjct: 200 DLIQEFGLQFQSRLCVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 254
Score = 169 bits (427), Expect = 1e-41
Identities = 81/188 (43%), Positives = 126/188 (67%)
Query: 648 KCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEF 707
+C GP+DLVFVID S+S+ FE ++QF+ G++ L + P A RVG++QYS+QV + F
Sbjct: 27 RCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVF 86
Query: 708 TLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFT 767
LR F+ +DM++A+ + + +G+MTGLA+++ +F+ EGARP RVPR A++ T
Sbjct: 87 PLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVT 146
Query: 768 DGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEIS 827
DGR QD V+E A++A+A GI +YAVGV +A L+ +AS P ++H+F E F + E
Sbjct: 147 DGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFG 206
Query: 828 EKLKKGIC 835
+ + +C
Sbjct: 207 LQFQSRLC 214
Score = 155 bits (393), Expect = 1e-37
Identities = 87/235 (37%), Positives = 133/235 (56%), Gaps = 3/235 (1%)
Query: 51 CENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFS 110
C DLV ++D S+SV ++ VK F+ I+ FLD+ P+ TRVGL+Q+ S V+ EF
Sbjct: 257 CREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFP 316
Query: 111 LKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTD 170
L + +EV++AV + ++ GTMTGLA+++ + +FSEA+GARP NVPRV ++ TD
Sbjct: 317 LGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTD 376
Query: 171 GRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTS 230
GR QD ++ AA+A++ GI+++A+GVG+ L+ I SEP E HV +F + L
Sbjct: 377 GRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLE 436
Query: 231 VFQKKLCTAHMCST---LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDL 282
+ +C S L C + + LN Q T R++DL
Sbjct: 437 NLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDL 491
Score = 52.0 bits (123), Expect = 3e-06
Identities = 22/44 (50%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 480 KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
+ C R D C DHGCE+ CV+ S+ C CPEG L++DGK+C
Sbjct: 212 RLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSC 254
Score = 46.6 bits (109), Expect = 1e-04
Identities = 23/51 (45%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 516 LRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR 566
L+ + C + D C DHGCE CVS S+ C C EG L+ DGK+C R
Sbjct: 207 LQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
+ L + CV D C +HGCE +CV+ SY C C EG L D K+C +
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/53 (37%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRR 402
F L + C + D C +HGC+ +CV+ SY C C +G L D K+C R
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/66 (37%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 432 YTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-----VD 486
+ L + C R D C DHGCE C++ S+ C C EG + D K+C+R VD
Sbjct: 205 FGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVD 263
Query: 487 YCLLSD 492
LL D
Sbjct: 264 LVLLVD 269
Score = 38.1 bits (87), Expect = 0.039
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR 443
++ F L + C R + C GCE +CV+ SY C C G L +GK+C+R
Sbjct: 202 IQEFGLQFQSRLCVR-DLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNR 256
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 276 bits (705), Expect = 8e-74
Identities = 147/413 (35%), Positives = 210/413 (50%), Gaps = 21/413 (5%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GS+ CRC G+ L+ ++ C D C + C +CVN PGSF C+C+ GY
Sbjct: 1089 CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGY-- 1146
Query: 312 AEDG----KRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
E G K C+ +D C C CVN +GS+ C C G L+P ++ C I+ C+
Sbjct: 1147 -ESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECS 1205
Query: 367 SSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
S++ C++ +CVN +Y C C G+ PD++ C I+ C + GC+ +C N E SY
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYE 1265
Query: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C C GY L P+G++C+ +D C C+ C N + C C +GF+ + D+KTC
Sbjct: 1266 CSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCID 1325
Query: 485 VDYCLLSDHGCEY-SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE--HSCV 541
V+ C L+ + C + C N SF C C G+ ++ C +D C +G H C+ SC+
Sbjct: 1326 VNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL 1385
Query: 542 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC--EHICVNSDDSYTCECLEGFRLA 599
+ SF C C EG+I +G C D C H C CVN+ SY C C EGF
Sbjct: 1386 NIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--T 1441
Query: 600 EDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
DG C D C + CE+ C+N +Y C+C GF A D R C+ E
Sbjct: 1442 GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDE 1494
Score = 259 bits (662), Expect = 8e-69
Identities = 143/417 (34%), Positives = 205/417 (49%), Gaps = 16/417 (3%)
Query: 253 CINIPGSYVCRCKQGYILN-SDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYA 310
C+N PGS+ C C +GY C D C C CVN GSF C C G+
Sbjct: 1131 CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
Query: 311 LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
L+ + CV ++ C+ ++ C + +CVN G+Y C C+ G+ PD++ CT ID C N
Sbjct: 1191 LSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
Query: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-HECVNMEESYYCRC 428
GC +C N++ SY C C +G+ L PD ++C I+ C N C+ +C N+ Y C C
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLC 1310
Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
+ G+ + KTC V+ C + C C NT+ SF+C C G+ + + C+ VD
Sbjct: 1311 YDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDE 1370
Query: 488 CLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
C + H C+ SC+N+ SF C C EG + +G C LD C+ G H C CV++
Sbjct: 1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWI--GNGIKCIDLDECSNGTHQCSINAQCVNT 1428
Query: 544 EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDG 602
S+ C C EG+ DG TC D C + CE+ C+N +Y CEC GF A D
Sbjct: 1429 PGSYRCACSEGF--TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDS 1486
Query: 603 KRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE--GPIDLV 657
+ C+ D C + C N + C C +G+ L G C E PI+ V
Sbjct: 1487 RSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCV 1543
Score = 253 bits (645), Expect = 8e-67
Identities = 142/422 (33%), Positives = 199/422 (47%), Gaps = 12/422 (2%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C+N GS+ C C G+ L+ + C + C++ D+ C CVN+ G++ C C GY
Sbjct: 1174 CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQA 1233
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
D + C +D C N GC+ +C N++GSY C C EG+AL PD ++C ID C ++
Sbjct: 1234 TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDI 1293
Query: 372 CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCH 429
C +C N Y C C GF + D KTC +N C LN C EC N + S+ C C
Sbjct: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQ 1353
Query: 430 RGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
GY++ C+ VD C H C+ CLN SF C C EG++ N +K C +D
Sbjct: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGN-GIK-CIDLDE 1411
Query: 488 CLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSE 544
C H C + CVN S+ C C EG DG TC+ +D CA + CE+ C++
Sbjct: 1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAENINLCENGQCLNVP 1469
Query: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
++ C+C G+ D ++C+ D C + C N + C C +G+ L G
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529
Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSK 664
C D C + +CVN Y C C F L G C G L F G
Sbjct: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
Query: 665 SL 666
SL
Sbjct: 1590 SL 1591
Score = 234 bits (598), Expect = 2e-61
Identities = 139/443 (31%), Positives = 191/443 (43%), Gaps = 48/443 (10%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ---LCVNVPGSFVCQC 305
CA C+N GSY C C GY L DQ C+ D CA H+CE +C N+ G+F+C C
Sbjct: 2264 CAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCIC 2323
Query: 306 YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----- 359
G A DG+ CV + C ++ CE+ CVN GSY C+C+EGF + C
Sbjct: 2324 PPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQ 2383
Query: 360 ----------------------TKIDYCASSNHGCQHEC----VNTDDSYSCHCLKGFTL 393
TK + C G H+C + Y C G
Sbjct: 2384 GLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY 2443
Query: 394 NPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
D R I+ C + C + +C+N S+ C C GYT D +G +C +D C+Q
Sbjct: 2444 TTDG---RDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPK 2500
Query: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
C +C NTE S+ C C G+++ ED KTC +D C H C++ CVN F C+CP
Sbjct: 2501 PCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPP 2560
Query: 513 G----HVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
G H D C S G + C ++ SF C+C G+ L G C D
Sbjct: 2561 GFTQHHTACIDNNECGSQPSLC----GAKGICQNTPGSFSCECQRGFSLDATGLNCEDVD 2616
Query: 569 VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
C +H C+H C N Y C C +G+ +C ++ C + + C N S
Sbjct: 2617 ECDG-NHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGS 2675
Query: 629 YICKCSEGFVLAEDGRRCKKCTE 651
Y C C GF + C E
Sbjct: 2676 YKCACPSGFSFDQFSSACHDVNE 2698
Score = 211 bits (538), Expect = 2e-54
Identities = 135/460 (29%), Positives = 197/460 (42%), Gaps = 60/460 (13%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300
C + C C N GSY C C +GY L D +C D C C+ C N+PG
Sbjct: 1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
+ C CY G+ + D K C+ V+ C ++ C EC N GS++C C G+++ C
Sbjct: 1306 YRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC 1365
Query: 360 TKIDYCASSNHGC--QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EH 415
T +D C H C C+N S+ C C +G+ N K C ++ C+ C
Sbjct: 1366 TDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIK--CIDLDECSNGTHQCSINA 1423
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFL 474
+CVN SY C C G+T D G TCS VD CA+ + CE CLN ++ C+C GF
Sbjct: 1424 QCVNTPGSYRCACSEGFTGD--GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT 1481
Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
D ++C +D C + +C N+ F C C +G+ L G C +D CA +
Sbjct: 1482 PASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPIN 1541
Query: 535 GCEHSCVSSEDSFVCQCFEGYILREDGKTC------------------------------ 564
CV++ + C C + L G C
Sbjct: 1542 CVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1601
Query: 565 RRKDVCQAIDHGCEHIC-----VNSDDSYT-CECLEGFR------LAEDGKRCRR-KDVC 611
R C ++ + C VNS + YT C EGFR + ED C+ +C
Sbjct: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661
Query: 612 KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
+ + C+N S+ C+C +G+ L+ED R C+ E
Sbjct: 1662 QGGN------CINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
Score = 211 bits (537), Expect = 3e-54
Identities = 138/489 (28%), Positives = 209/489 (42%), Gaps = 97/489 (19%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTC---RIQDLCAMEDHNCEQLCVN-VPGSF---VCQC 305
C+N GS+ C C +G L+ C R++ D E C++ VPG F C C
Sbjct: 971 CVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD---EDECIHPVPGKFRMDACCC 1027
Query: 306 YSGYALAEDGKRCVA-------------------------------VDYCASENHGCEH- 333
G A + + C ++ C + C +
Sbjct: 1028 AVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG 1087
Query: 334 ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH------------------- 374
+C N GS+ C+C+ GFAL+ +++ CT ID C S C
Sbjct: 1088 KCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE 1147
Query: 375 -------------------------ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
CVNT+ S+ C C G L+P ++ C IN C+L+
Sbjct: 1148 SGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLS 1207
Query: 410 KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
C + +CVNM +Y C C+ GY P+ + C+ +D C + GC+ C N+E S+ C
Sbjct: 1208 DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECS 1267
Query: 469 CSEGFLINEDLKTCSRVDYCLLSDHGCE-YSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 527
CSEG+ + D ++C+ +D C + C+ C N+ + C C +G + D KTC ++
Sbjct: 1268 CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN 1327
Query: 528 SCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
C L + C C +++ SF+C C GY +++ C D C+ H C+ C+N
Sbjct: 1328 ECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
Query: 585 DDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICKCSEGFVLAED 642
S+ C C EG+ +G +C D C + H C CVN SY C CSEGF D
Sbjct: 1388 PGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGD 1443
Query: 643 GRRCKKCTE 651
G C E
Sbjct: 1444 GFTCSDVDE 1452
Score = 207 bits (528), Expect = 3e-53
Identities = 119/380 (31%), Positives = 167/380 (43%), Gaps = 40/380 (10%)
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
C+N GSF C+C GY L G RCV D C+ N C N GS+ C C+EGF
Sbjct: 2187 CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG 2246
Query: 354 PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
P C I+ CA + C C+NT SY C C G+ L D+K C+ ++ CA C
Sbjct: 2247 P-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
Query: 414 EHE---CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQC 469
E C N+ ++ C C G P+G+ C + C + CE C+N S+ C+C
Sbjct: 2306 ESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCEC 2365
Query: 470 SEGFLINEDLKTC--SRVDYCLLS-----------------------------DHGCEYS 498
+EGF + C +R C H CE
Sbjct: 2366 NEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELC 2425
Query: 499 CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYIL 557
+ + CP G +DG+ +D C + + C + C+++ SF C C GY
Sbjct: 2426 PLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTT 2482
Query: 558 REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG 617
G +C D C C +IC N++ SY C C G+ L EDGK C+ D C++ H
Sbjct: 2483 DISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHN 2542
Query: 618 CEHICVNNGNSYICKCSEGF 637
C+ +CVN + CKC GF
Sbjct: 2543 CQFLCVNTLGGFTCKCPPGF 2562
Score = 207 bits (527), Expect = 4e-53
Identities = 138/452 (30%), Positives = 205/452 (45%), Gaps = 55/452 (12%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
C N GS++C C+ GY + T C D C + HNC+ C+N+PGSF C C G+
Sbjct: 1341 CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWI 1400
Query: 311 LAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
+G +C+ +D C++ H C +CVN GSY C C EGF D TC+ +D CA +
Sbjct: 1401 --GNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT--GDGFTCSDVDECAEN 1456
Query: 369 NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427
+ C++ +C+N +Y C C GFT D ++C+ I+ C+ C N+ ++C
Sbjct: 1457 INLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI 1516
Query: 428 CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485
C GY LD G C+ +D CA + LC+NT + C C F +N C +RV
Sbjct: 1517 CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRV 1576
Query: 486 DYCLLS---DHGCEYSC-----VNMDRSFACQCPEGHVLRSDGKTCAKLDS------CAL 531
C L SC V + RS +C C G + +TC ++S C
Sbjct: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRS-SCCCSLGKAWGNPCETCPPVNSTEYYTLCPG 1635
Query: 532 GD--------------HGCEH--------SCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569
G+ C+ +C+++ SF C+C +GY L ED + C D
Sbjct: 1636 GEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE 1695
Query: 570 CQAIDHGC-EHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG--CEHICVN 624
C A C C N+ +YTC C + G C RK C +++G CE+
Sbjct: 1696 CFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPF 1755
Query: 625 NGNSYICKCSEGFVLAEDGRRCKKC-TEGPID 655
N +C C+ A + + C+ C T G D
Sbjct: 1756 NVTKRMCCCTYNVGKAWN-KPCEPCPTPGTAD 1786
Score = 188 bits (478), Expect = 2e-47
Identities = 133/434 (30%), Positives = 186/434 (42%), Gaps = 37/434 (8%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
F + G+ V QG I+ + D+C + C C+ S+ C+C GY
Sbjct: 467 FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYK 526
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
+G C+ VD C S N +CVN GSY C+CH GF P K+ C ID C +
Sbjct: 527 QDANGD-CIDVDECTS-NPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGV 584
Query: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
C++ CVNTD S+ C C GF L D K C + C C+N + S+ C C
Sbjct: 585 LCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICK 644
Query: 430 RGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS------ 483
G+ L PNG+ C+ VD C C+N+E SF C C G + D + C
Sbjct: 645 PGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRS 704
Query: 484 ------RVDYCLLSDHGC----EYSCVNMDRSFA--CQ-CP-----EGHVLRSDGKTCA- 524
+ C+ G E C N D F CQ CP E H L S G
Sbjct: 705 TCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV 764
Query: 525 ---KLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH- 579
++ CAL C + C + S+ C C GY G+ C D C C++
Sbjct: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG 824
Query: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFV 638
+C N+ SY+C C G+ + + C + C+S + C + C NN S+ C+CS G
Sbjct: 825 LCRNTPGSYSCTCPPGYVFRTETETCEDINECES--NPCVNGACRNNLGSFNCECSPGSK 882
Query: 639 LAEDGRRCKKCTEG 652
L+ G C +G
Sbjct: 883 LSSTGLICIDSLKG 896
Score = 187 bits (476), Expect = 3e-47
Identities = 138/493 (27%), Positives = 202/493 (40%), Gaps = 86/493 (17%)
Query: 242 CSTLEHNCAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
C + + C+H C+++ GSY C C G+ + DQT C D C E H C C N G
Sbjct: 1896 CLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTVG 1953
Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEH-ECVNADGSYLCQCHEGFALNPDKK 357
S+ C CY G+ L + C+ +D C+S C + C N GS+ C C+EG+ L PD K
Sbjct: 1954 SYNCLCYPGFELTHNND-CLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGK 2012
Query: 358 TCTKIDYCAS-----SNHGCQH------------------------------------EC 376
C + C + S CQ+ C
Sbjct: 2013 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSC 2072
Query: 377 VNTDDSYSCHCLKGFTLNPDKKTC--RRINYCALN-----------------------KP 411
NT + C C GF L+ + + C R ++C N P
Sbjct: 2073 TNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMP 2132
Query: 412 G------CEHECVNMEESYYCRCHRGYTLDPN-GKTCSRVDHCAQQDHGCEQ-LCLNTED 463
G CE + E ++ C G+ P+ T V+ C + C C+NT+
Sbjct: 2133 GEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDG 2192
Query: 464 SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
SF C+C G+ ++ C D C + + +C N+ SF C C EG C
Sbjct: 2193 SFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFE-PGPMMNC 2251
Query: 524 AKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH---I 580
++ CA C C+++ S+ C C GY LRED K C+ D C H CE +
Sbjct: 2252 EDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
Query: 581 CVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVL 639
C N ++ C C G DG+ C ++ C++ CE+ CVN SY C+C+EGF
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQS 2371
Query: 640 AEDGRRCKKCTEG 652
+ G C +G
Sbjct: 2372 SSSGTECLDNRQG 2384
Score = 182 bits (462), Expect = 1e-45
Identities = 127/468 (27%), Positives = 191/468 (40%), Gaps = 69/468 (14%)
Query: 237 CTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCV 295
CT++ C+ + C+N PGSY C+C G+ + C D C C+ CV
Sbjct: 539 CTSNPCTNGD------CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCV 592
Query: 296 NVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPD 355
N GSF C C +G+ L DGK CV D C + N C+N DGS+ C C GF L P+
Sbjct: 593 NTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPN 652
Query: 356 KKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNK 410
+ CT +D C + C+N++ S+ C C G + D + C R Y + K
Sbjct: 653 GRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKK 712
Query: 411 PGC-----------EHECVNME---------------ESYYCRCHRGYTLDPNGKTCSRV 444
C E C N + ++ C G + +G+ +
Sbjct: 713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRD---I 769
Query: 445 DHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNM 502
+ CA C +C N S+ C C+ G+ + + C +D CL++ C+ C N
Sbjct: 770 NECALDPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNT 829
Query: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDG 561
S++C CP G+V R++ +TC ++ C + C + +C ++ SF C+C G L G
Sbjct: 830 PGSYSCTCPPGYVFRTETETCEDINECE--SNPCVNGACRNNLGSFNCECSPGSKLSSTG 887
Query: 562 KTC--RRKDVC--QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-----K 612
C K C D CE + C G +RC C +
Sbjct: 888 LICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLAR 947
Query: 613 STHHGCEHI--------------CVNNGNSYICKCSEGFVLAEDGRRC 646
CE + CVN+ S+ C+C EG L GR C
Sbjct: 948 IKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVC 995
Score = 182 bits (462), Expect = 1e-45
Identities = 122/401 (30%), Positives = 172/401 (42%), Gaps = 46/401 (11%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GS+ C C +GY L D C + C +C C N+ GSF C C GY +
Sbjct: 1990 CFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEV 2049
Query: 312 AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC----------- 359
+ C+ ++ C + + C C N G + C C GF L+ + + C
Sbjct: 2050 KSEN--CIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN 2107
Query: 360 --------------TKIDYCASSNHG------CQHECVNTDDSYSCHCLKGFTLNPDKKT 399
TK C S G C+ + + ++ C G P
Sbjct: 2108 FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHD 2167
Query: 400 CRR-INYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456
R +N C L PG C + +C+N + S+ C C GY LD G C D C+ +
Sbjct: 2168 TREDVNEC-LESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226
Query: 457 LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVL 516
C N SF C C+EGF + C ++ C + C + C+N S+ C CP G+ L
Sbjct: 2227 TCTNVIGSFECNCNEGFEPG-PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYAL 2285
Query: 517 RSDGKTCAKLDSCALGDHGCEH---SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI 573
R D K C LD CA G H CE C + +F+C C G R DG+ C ++ C+
Sbjct: 2286 REDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTK 2345
Query: 574 DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVC 611
CE+ CVN SY CEC EGF+ + G C R+ +C
Sbjct: 2346 PGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386
Score = 182 bits (461), Expect = 2e-45
Identities = 101/322 (31%), Positives = 145/322 (45%), Gaps = 12/322 (3%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
C + + C + CIN GS+ C CK GY + T+C D C+ C +C N GS
Sbjct: 2453 CKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGS 2512
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
+ C C GY L EDGK C +D C ++ H C+ CVN G + C+C GF + C
Sbjct: 2513 YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH--HTACI 2570
Query: 361 KIDYCAS--SNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
+ C S S G + C NT S+SC C +GF+L+ C ++ C N C+H C
Sbjct: 2571 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHR-CQHGCQ 2629
Query: 419 NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
N+ Y C C +GY C + C+ + C NT S+ C C GF ++
Sbjct: 2630 NILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQF 2689
Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA-----KLDSCALGD 533
C V+ C S + C Y C N + + C CP G+ G + K +L
Sbjct: 2690 SSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDT 2749
Query: 534 HGCEHSCVSSEDSFVCQCFEGY 555
E + +S E + C+ GY
Sbjct: 2750 EVDEENALSPEACYECK-INGY 2770
Score = 181 bits (460), Expect = 2e-45
Identities = 128/461 (27%), Positives = 189/461 (40%), Gaps = 70/461 (15%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTC--RIQDLCAM--EDHNCEQLCVNVPGSFV---CQC 305
C N GS+ C C G L+S C ++ C + +D CE VN+ G+ + C
Sbjct: 866 CRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE---VNINGATLKSECCA 922
Query: 306 YSGYALAEDGKRCVAVDYC-----------ASENHGCE--------HECVNADGSYLCQC 346
G A +RC C + + CE CVN+ GS+ C+C
Sbjct: 923 TLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCEC 982
Query: 347 HEGFALNPDKKTCTKID----YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC-- 400
EG L+ + C I Y C H +C C G + + C
Sbjct: 983 PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPK 1042
Query: 401 -----------------------------RRINYCALNKPGCEH-ECVNMEESYYCRCHR 430
+ IN C C + +C N S+ CRC+
Sbjct: 1043 PGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNS 1102
Query: 431 GYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFLIN-EDLKTCSRVDYC 488
G+ LD + C+ +D C C +C+NT SF C+C EG+ +K C +D C
Sbjct: 1103 GFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDEC 1162
Query: 489 LLSDHGCE-YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDS 546
+ C +CVN + SF C CP GH L + C ++ C+L D+ C + CV+ +
Sbjct: 1163 ERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGT 1222
Query: 547 FVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCR 606
+ C C GY D + C D C ++ GC+ C NS+ SY C C EG+ L DG+ C
Sbjct: 1223 YQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1282
Query: 607 RKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRC 646
D C++ C+ C N Y C C +GF+ + D + C
Sbjct: 1283 DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Score = 157 bits (396), Expect = 6e-38
Identities = 114/440 (25%), Positives = 170/440 (38%), Gaps = 65/440 (14%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C+N+PG+Y C C+ G+ SD +C+ D C+ ++ C N+PG F C C GY L
Sbjct: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
Query: 313 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC--TKIDYC----- 365
G C +D CA + CVN G Y C C F LNP C ++ C
Sbjct: 1525 RTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFG 1584
Query: 366 --ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
+ C E SC C G +TC +N
Sbjct: 1585 PRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN----------------STE 1628
Query: 424 YYCRCHRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLK 480
YY C G PN T +D C + C+ C+NT SF C+C +G+ ++ED +
Sbjct: 1629 YYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTR 1688
Query: 481 TCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKL--DSCALGDHG-- 535
C +D C C +C N ++ C CP ++ + G C + C +G
Sbjct: 1689 ICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTT 1748
Query: 536 CEHSCVSSEDSFVCQC-----------------------------FEGYILREDGKTCRR 566
CE+ + +C C G+
Sbjct: 1749 CENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVD 1808
Query: 567 KDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH--ICV 623
D C+ I C + +C+N S+ CEC GF + C D C + + C+ C+
Sbjct: 1809 IDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
Query: 624 NNGNSYICKCSEGFVLAEDG 643
N+ SY C+C+ GF L+ +G
Sbjct: 1869 NSPGSYRCECAAGFKLSPNG 1888
Score = 155 bits (392), Expect = 2e-37
Identities = 127/466 (27%), Positives = 176/466 (37%), Gaps = 79/466 (16%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C N+PG + C C GY L+ C D CA + LCVN PG + C C + L
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLN 1565
Query: 313 EDGKRCV------------------------------AVDYCASENHGCEHEC-----VN 337
G CV C S + C VN
Sbjct: 1566 PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVN 1625
Query: 338 ADGSY-LCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNP 395
+ Y LC EGF NP ID C CQ C+NT S+ C C +G+ L+
Sbjct: 1626 STEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSE 1685
Query: 396 DKKTCRRINYCALNKPGC-EHECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDH 452
D + C I+ C + C C N +Y C C Y G C R C + +
Sbjct: 1686 DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYN 1745
Query: 453 G--CE---------QLCLNTED--------------------SFVCQCSEGFLINEDLKT 481
G CE ++C T + +C GF +
Sbjct: 1746 GTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1805
Query: 482 CSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS- 539
+D C C C+N SF C+CP G C +D C+ GD+ C+ +
Sbjct: 1806 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1865
Query: 540 -CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFR 597
C++S S+ C+C G+ L +G C ++ C I + C H +CV+ SY C C GF+
Sbjct: 1866 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1924
Query: 598 LAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAED 642
++D C D C+ H C + C N SY C C GF L +
Sbjct: 1925 ASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLCYPGFELTHN 1968
Score = 127 bits (319), Expect = 5e-29
Identities = 79/270 (29%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLI 475
C+ SY C C+ GY D NG C VD C + C C+NT S+ C+C GF
Sbjct: 510 CIPTVSSYRCECNMGYKQDANG-DCIDVDECT--SNPCTNGDCVNTPGSYYCKCHAGFQR 566
Query: 476 NEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
+ C +D C+ + C+ CVN D SF C C G L +DGK C D C +
Sbjct: 567 TPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNM 626
Query: 535 GCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLE 594
C++ + SF C C G++L +G+ C D CQ C+NS+ S+ C+C
Sbjct: 627 CLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPP 686
Query: 595 GFRLAEDGKRC------------RRKDVCKSTHHG-------------------CEHICV 623
G + DG+ C +K VC G C+
Sbjct: 687 GLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPA 746
Query: 624 NNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
N + CS G + DGR +C P
Sbjct: 747 KNSAEFHGLCSSGVGITVDGRDINECALDP 776
Score = 79.3 bits (194), Expect = 2e-14
Identities = 77/311 (24%), Positives = 111/311 (35%), Gaps = 67/311 (21%)
Query: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354
NV GS F C G+ G +C+ V C + C +GF P
Sbjct: 87 NVCGSRFHSYCCPGWKTLPGGNQCI-VPICRNS------------------CGDGFCSRP 127
Query: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI---NYCALNKP 411
+ TC+ ++ +C S C+ G T D C++ YC +P
Sbjct: 128 NMCTCSSGQISSTCGSKSIQQC-------SVRCMNGGTCADDHCQCQKGYIGTYCG--QP 178
Query: 412 GCEHECVNMEESY---YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
CE+ C N C C G+T P + R C Q + Q+C VC
Sbjct: 179 VCENGCQNGGRCIGPNRCACVYGFT-GPQCERDYRTGPCFTQVNN--QMCQGQLTGIVCT 235
Query: 469 -------------------------CSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVNM 502
C GF+ N C VD C C+ +C+N
Sbjct: 236 KTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINT 295
Query: 503 DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDG 561
SF C+CP GH + C +D C++ CE C ++ S+ C C GY+ DG
Sbjct: 296 VGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDG 355
Query: 562 KTC--RRKDVC 570
C +R +C
Sbjct: 356 SRCIDQRTGMC 366
Score = 70.1 bits (170), Expect = 9e-12
Identities = 49/166 (29%), Positives = 69/166 (41%), Gaps = 11/166 (6%)
Query: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
V K LC C+T+ H C P C++G+I N C+ D C C
Sbjct: 233 VCTKTLC----CATIGRAWGHPCEMCPAQPQ-PCRRGFIPNIRTGACQDVDECQAIPGIC 287
Query: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348
+ C+N GSF C+C +G+ +E ++C +D C+ CE EC N GSY C C
Sbjct: 288 QGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPR 347
Query: 349 GFALNPDKKTC----TKIDYCASSNHGCQHECVNTDDSYSCHCLKG 390
G+ + D C T + + N C E C C G
Sbjct: 348 GYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPG 393
Score = 67.8 bits (164), Expect = 5e-11
Identities = 69/257 (26%), Positives = 88/257 (34%), Gaps = 49/257 (19%)
Query: 426 CR--CHRGYTLDPNGKTCSR---VDHCAQQD-HGCEQLCLN--TEDSFVCQCSEGFLINE 477
CR C G+ PN TCS C + C C+N T CQC +G++
Sbjct: 115 CRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGT- 173
Query: 478 DLKTCSRVDYCLLSDHGCEYSCVNMDRSFA---CQCPEGHVL------------------ 516
YC CE C N R C C G
Sbjct: 174 ---------YC--GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNN 222
Query: 517 -----RSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ G C K CA H C C G+I C+ D CQ
Sbjct: 223 QMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ-PQPCRRGFIPNIRTGACQDVDECQ 281
Query: 572 AIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSY 629
AI C+ C+N+ S+ C C G + +E ++C D C CE C N SY
Sbjct: 282 AIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSY 341
Query: 630 ICKCSEGFVLAEDGRRC 646
C C G+V + DG RC
Sbjct: 342 FCVCPRGYVTSTDGSRC 358
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 273 bits (697), Expect = 7e-73
Identities = 141/370 (38%), Positives = 191/370 (51%), Gaps = 17/370 (4%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDH-NCEQLCVNVPGSFVCQCYSGYAL 311
C N P SY C CK GY D C+ D C ED+ C CVN+PG++ C CY G+ L
Sbjct: 46 CQNTPRSYKCICKSGY--TGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHL 103
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
A DG C+ VD CA N GC+ CVN GSY C C EGF L+ ++ TC + C +
Sbjct: 104 AHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMN 163
Query: 368 SNHGCQHECVNT-DDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
NHGC H C T +C C GF L +++ C+ C GC+H C + E+ C
Sbjct: 164 KNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRC 221
Query: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
CH + L +GKTC ++ CA + GC+ C + C C GF++ D KTC +D
Sbjct: 222 GCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDID 279
Query: 487 YCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDS 546
C L++ GC++ C N SF C C +G+ L + + C +D C+ D C+H CV++ S
Sbjct: 280 ECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSF-DRTCDHICVNTPGS 338
Query: 547 FVCQCFEGYILREDGKT-CRRKDVCQAIDHGCEHICVNSDDSYTCECLEG-FRLAEDGKR 604
F C C GY+L G T C D C GC C+N+ SY C C G RL +GK
Sbjct: 339 FQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKD 396
Query: 605 CRRKDVCKST 614
C C+ +
Sbjct: 397 CTEPLKCQGS 406
Score = 258 bits (659), Expect = 2e-68
Identities = 141/382 (36%), Positives = 186/382 (48%), Gaps = 24/382 (6%)
Query: 281 DLCAMEDHNC--EQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
D C NC + +C N P S+ C C SGY DGK C VD C E N GC H+CVN
Sbjct: 31 DECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCVN 88
Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
G+Y C C++GF L D C +D CA N GCQ CVN SY CHC +GF L+ ++
Sbjct: 89 IPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQ 148
Query: 398 KTC----RRINYCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
TC C GC H C + C C G+ L N + C C +
Sbjct: 149 HTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT--CNYGNG 206
Query: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE 512
GC+ C +TE C C F+++ D KTC ++ C +++ GC+ C + C CP
Sbjct: 207 GCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGVHCTCPV 264
Query: 513 GHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQA 572
G +L+ D KTC +D C L + GC+H C ++ SF C C +GY L + + C+ D C +
Sbjct: 265 GFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDEC-S 323
Query: 573 IDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICK 632
D C+HICVN+ S+ C C G+ L C D C GC C+N SY C
Sbjct: 324 FDRTCDHICVNTPGSFQCLCHRGY-LLYGITHCGDVDECSINRGGCRFGCINTPGSYQCT 382
Query: 633 CSEGFVLAEDGR---RCKKCTE 651
C G GR K CTE
Sbjct: 383 CPAG-----QGRLHWNGKDCTE 399
Score = 235 bits (600), Expect = 1e-61
Identities = 122/332 (36%), Positives = 170/332 (51%), Gaps = 18/332 (5%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
C H C+NIPG+Y C C G+ L D C D CA + C+Q CVN+ GS+ C C G
Sbjct: 82 CVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREG 141
Query: 309 YALAEDGKRCVAVD----YCASENHGCEHEC-VNADGSYLCQCHEGFALNPDKKTCTKID 363
+ L+++ C+ C ++NHGC H C G C+C GF L +++ C
Sbjct: 142 FFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT- 200
Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEES 423
C N GCQH C +T+ C C F L+ D KTC I CA+N GC+ +C +
Sbjct: 201 -CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATG 257
Query: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF--LINEDLKT 481
+C C G+ L P+ KTC +D C + GC+ +C NT SF C C +G+ LINE +
Sbjct: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINE--RN 315
Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKT-CAKLDSCALGDHGCEHSC 540
C +D C D C++ CVN SF C C G++L G T C +D C++ GC C
Sbjct: 316 CQDIDECSF-DRTCDHICVNTPGSFQCLCHRGYLLY--GITHCGDVDECSINRGGCRFGC 372
Query: 541 VSSEDSFVCQCFEGY-ILREDGKTCRRKDVCQ 571
+++ S+ C C G L +GK C CQ
Sbjct: 373 INTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404
Score = 216 bits (550), Expect = 8e-56
Identities = 110/311 (35%), Positives = 160/311 (51%), Gaps = 13/311 (4%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTC--RIQD--LCAMEDHNCEQLCVNV 297
C+ C C+N+ GSY C C++G+ L+ +Q TC R ++ C ++H C +C
Sbjct: 116 CAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 175
Query: 298 P-GSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDK 356
P G C+C G+ L ++ + C C N GC+H C + + C CH F L+ D
Sbjct: 176 PKGGIACECRPGFELTKNQRDCKLT--CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDG 233
Query: 357 KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
KTC I+ CA +N GC +C + C C GF L PD+KTC+ I+ C LN GC+H
Sbjct: 234 KTC--IETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHI 291
Query: 417 CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLIN 476
C N S+ C C +GY L N + C +D C+ D C+ +C+NT SF C C G+L+
Sbjct: 292 CRNTVGSFECSCKKGYKLLINERNCQDIDECS-FDRTCDHICVNTPGSFQCLCHRGYLL- 349
Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH-VLRSDGKTCAKLDSCALGDHG 535
+ C VD C ++ GC + C+N S+ C CP G L +GK C + C G G
Sbjct: 350 YGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPG 408
Query: 536 CEHSCVSSEDS 546
+ +S S
Sbjct: 409 ASKAMLSCNRS 419
Score = 202 bits (513), Expect = 2e-51
Identities = 104/307 (33%), Positives = 155/307 (50%), Gaps = 14/307 (4%)
Query: 357 KTCTKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCAL-NKPGC 413
K +D C C + C NT SY C C G+T D K C+ ++ C + GC
Sbjct: 25 KAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGC 82
Query: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
H+CVN+ +Y C C+ G+ L +G C VD CA+ + GC+Q C+N S+ C C EGF
Sbjct: 83 VHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGF 142
Query: 474 LINEDLKTCSRVDY----CLLSDHGCEYSCVNMDRS-FACQCPEGHVLRSDGKTCAKLDS 528
++++ TC + C+ +HGC + C + AC+C G L + + C KL +
Sbjct: 143 FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDC-KL-T 200
Query: 529 CALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSY 588
C G+ GC+H+C +E C C ++L DGKTC + C + GC+ C ++
Sbjct: 201 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCI--ETCAVNNGGCDSKCHDAATGV 258
Query: 589 TCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
C C GF L D K C+ D C+ + GC+HIC N S+ C C +G+ L + R C+
Sbjct: 259 HCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQD 318
Query: 649 CTEGPID 655
E D
Sbjct: 319 IDECSFD 325
Score = 114 bits (285), Expect = 4e-25
Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 13/219 (5%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
C+ C C + C C G++L D+ TC+ D C + + C+ +C N GSF
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSF 299
Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
C C GY L + + C +D C S + C+H CVN GS+ C CH G+ L C
Sbjct: 300 ECSCKKGYKLLINERNCQDIDEC-SFDRTCDHICVNTPGSFQCLCHRGYLLY-GITHCGD 357
Query: 362 IDYCASSNHGCQHECVNTDDSYSCHCLKG-FTLNPDKKTCRRINYCALNKPGCEHECVNM 420
+D C+ + GC+ C+NT SY C C G L+ + K C C PG ++
Sbjct: 358 VDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ-GSPGASKAMLS- 415
Query: 421 EESYYCRCHRGYTLDPNGKTC-SRVDHCAQQDHGCEQLC 458
C+R D TC SR + ++G C
Sbjct: 416 -------CNRSGKKDTCALTCPSRARFLPESENGFTVSC 447
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 255 bits (652), Expect = 1e-67
Identities = 133/388 (34%), Positives = 189/388 (48%), Gaps = 42/388 (10%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAME-DHNCEQLCVNVPGSFVCQCYSGYAL 311
C N P SY C CK GY + C D C E + C C+N+PG++ C C+ G+ L
Sbjct: 62 CQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFML 119
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID----YCAS 367
A DG C+ VD C N GC+H CVN GSY C C EGF L+ ++ TC C +
Sbjct: 120 AHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMN 179
Query: 368 SNHGCQHECVNTD-DSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC 426
+HGC H C S +C C GF L +++ C I C GC+H C + + C
Sbjct: 180 KDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNGGCQHSCDDTADGPEC 237
Query: 427 RCHRGYTLDPNGKTCSR----------------------------VDHCAQQDHGCEQLC 458
CH Y + +G++C ++ CA + GC++ C
Sbjct: 238 SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTC 297
Query: 459 LNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS 518
+T C C GF + D KTC +D C + GC++ C N+ SF C C +G L +
Sbjct: 298 KDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLT 357
Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKT-CRRKDVCQAIDHGC 577
D K+C +D C+L D C+HSC++ +F C C GY L G T C + C + GC
Sbjct: 358 DEKSCQDVDECSL-DRTCDHSCINHPGTFACACNRGYTLY--GFTHCGDTNECSINNGGC 414
Query: 578 EHICVNSDDSYTCECLEGFRLAEDGKRC 605
+ +CVN+ SY C+C G++L + K C
Sbjct: 415 QQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 245 bits (626), Expect = 1e-64
Identities = 128/402 (31%), Positives = 192/402 (47%), Gaps = 42/402 (10%)
Query: 281 DLCA--MEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASE-NHGCEHECVN 337
D CA ++D + + LC N P S+ C C GY +G++C +D C +E N GC H+C+N
Sbjct: 47 DECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCLN 104
Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDK 397
G+Y C C +GF L D C +D C +N GCQH CVN SY C C +GF L+ ++
Sbjct: 105 IPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQ 164
Query: 398 KTCRRIN----YCALNKPGCEHECVNMEE-SYYCRCHRGYTLDPNGKTCSRVDHCAQQDH 452
TC + C GC H C S C C G+ L N + C + C +
Sbjct: 165 HTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGNG 222
Query: 453 GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR---------------------------- 484
GC+ C +T D C C + ++ D ++C
Sbjct: 223 GCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLL 282
Query: 485 VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSE 544
++ C +++ GC+ +C + C CP G L+ DGKTC +D C + GC+H C +
Sbjct: 283 METCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIV 342
Query: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKR 604
SF C C +G+ L D K+C+ D C ++D C+H C+N ++ C C G+ L
Sbjct: 343 GSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTL-YGFTH 400
Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
C + C + GC+ +CVN SY C+C G+ L + + C
Sbjct: 401 CGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 235 bits (600), Expect = 1e-61
Identities = 122/354 (34%), Positives = 175/354 (49%), Gaps = 39/354 (11%)
Query: 245 LEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ 304
L C H C+NIPG+Y C C G++L D C D C + C+ CVNV GS+ C
Sbjct: 94 LNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECC 153
Query: 305 CYSGYALAEDGKRCVAVD----YCASENHGCEHECVNAD-GSYLCQCHEGFALNPDKKTC 359
C G+ L+++ C+ C +++HGC H C A GS C+C GF L +++ C
Sbjct: 154 CKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC 213
Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC------------------- 400
I C N GCQH C +T D C C + ++ D ++C
Sbjct: 214 --ILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVV 271
Query: 401 -------RRI--NYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
RR+ CA+N GC+ C + +C C G+TL +GKTC +D C ++
Sbjct: 272 DGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRN 331
Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
GC+ C N SF C C +GF + D K+C VD C L D C++SC+N +FAC C
Sbjct: 332 GGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSL-DRTCDHSCINHPGTFACACN 390
Query: 512 EGHVLRSDGKT-CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
G+ L G T C + C++ + GC+ CV++ S+ CQC GY L + K C
Sbjct: 391 RGYTLY--GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDC 442
Score = 191 bits (485), Expect = 3e-48
Identities = 100/330 (30%), Positives = 150/330 (45%), Gaps = 40/330 (12%)
Query: 362 IDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN-KPGCEHECV 418
+D CA C + C NT SY C C G+ + + C I+ C GC H+C+
Sbjct: 46 VDECAQGLDDCHADALCQNTPTSYKCSCKPGY--QGEGRQCEDIDECGNELNGGCVHDCL 103
Query: 419 NMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
N+ +Y C C G+ L +G C VD C + + GC+ C+N S+ C C EGF ++++
Sbjct: 104 NIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDN 163
Query: 479 LKTCSRVDY----CLLSDHGCEYSCVNMDR-SFACQCPEGHVLRSDGKTCAKLDSCALGD 533
TC C+ DHGC + C R S AC+C G L + + C + +C G+
Sbjct: 164 QHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDC--ILTCNHGN 221
Query: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD------------------------- 568
GC+HSC + D C C Y + DG++C ++
Sbjct: 222 GGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRL 281
Query: 569 ---VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNN 625
C + GC+ C ++ C C GF L DGK C+ D C++ + GC+H C N
Sbjct: 282 LMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNI 341
Query: 626 GNSYICKCSEGFVLAEDGRRCKKCTEGPID 655
S+ C C +GF L D + C+ E +D
Sbjct: 342 VGSFDCGCKKGFKLLTDEKSCQDVDECSLD 371
Score = 173 bits (439), Expect = 6e-43
Identities = 88/274 (32%), Positives = 131/274 (47%), Gaps = 35/274 (12%)
Query: 242 CSTLEHNCAHFCINIP-GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 300
C +H C+H C P GS C C+ G+ L +Q C + C + C+ C +
Sbjct: 177 CMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL--TCNHGNGGCQHSCDDTADG 234
Query: 301 FVCQCYSGYALAEDGKRC----------------------------VAVDYCASENHGCE 332
C C+ Y + DG+ C + ++ CA N GC+
Sbjct: 235 PECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCD 294
Query: 333 HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFT 392
C + C C GF L D KTC ID C + N GC H C N S+ C C KGF
Sbjct: 295 RTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFK 354
Query: 393 LNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKT-CSRVDHCAQQD 451
L D+K+C+ ++ C+L++ C+H C+N ++ C C+RGYTL G T C + C+ +
Sbjct: 355 LLTDEKSCQDVDECSLDRT-CDHSCINHPGTFACACNRGYTL--YGFTHCGDTNECSINN 411
Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
GC+Q+C+NT S+ CQC G+ ++ + K C V
Sbjct: 412 GGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV 445
Score = 119 bits (299), Expect = 1e-26
Identities = 68/218 (31%), Positives = 94/218 (43%), Gaps = 20/218 (9%)
Query: 234 KKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL 293
K+ C+ C C + C C G+ L D TC+ D C + C+
Sbjct: 278 KRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHF 337
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
C N+ GSF C C G+ L D K C VD C S + C+H C+N G++ C C+ G+ L
Sbjct: 338 CKNIVGSFDCGCKKGFKLLTDEKSCQDVDEC-SLDRTCDHSCINHPGTFACACNRGYTLY 396
Query: 354 PDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
C + C+ +N GCQ CVNT SY C C G+ L+ +KK C + G
Sbjct: 397 -GFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVK-------GL 448
Query: 414 EHECVNMEESYYC-----------RCHRGYTLDPNGKT 440
V+ S +C RCH G L + T
Sbjct: 449 LPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTT 486
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 249 bits (637), Expect = 6e-66
Identities = 133/357 (37%), Positives = 174/357 (48%), Gaps = 24/357 (6%)
Query: 261 VCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVN----VPGSFV-CQCYSGYALAEDG 315
V RC +G++ D+ C + A LC + VPGS C C G+ G
Sbjct: 107 VLRCCRGWMQQPDEEGCLSAECSA-------SLCFHGGRCVPGSAQPCHCPPGF----QG 155
Query: 316 KRC-VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH 374
RC VD C + N GC+H CVN GSYLC+C GF L+ D +TC I+ CA N GCQH
Sbjct: 156 PRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQH 215
Query: 375 ECVN-TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
CV T + C C GF L D + C R + CA C H C + C CH GY
Sbjct: 216 HCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQ 275
Query: 434 LDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY-----C 488
L +GK C VD CA C CLNT+ SF C C G+ + D + C R++ C
Sbjct: 276 LAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSC 335
Query: 489 LLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFV 548
++ GC + C + C CP G+ L +D +TC +D CA C+ C ++ +
Sbjct: 336 EANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCA-DSPCCQQVCTNNPGGYE 394
Query: 549 CQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC 605
C C+ GY L DG C D C + GCEH C N S+ C C G+RL ED + C
Sbjct: 395 CGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGC 451
Score = 242 bits (617), Expect = 1e-63
Identities = 128/363 (35%), Positives = 173/363 (47%), Gaps = 16/363 (4%)
Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDKKTC 359
V +C G+ D + C++ + AS C H CV C C GF +
Sbjct: 107 VLRCCRGWMQQPDEEGCLSAECSASL---CFHGGRCVPGSAQP-CHCPPGFQ---GPRCQ 159
Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
+D C + N GCQH CVNT SY C C GF L+ D +TC IN CAL GC+H CV
Sbjct: 160 YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219
Query: 420 MEESYY-CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINED 478
+ + + C+C G+ L +G+ C R CA ++ C C C+C G+ + D
Sbjct: 220 LTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAAD 279
Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD-----SCALGD 533
K C VD C C + C+N SF C C G+ L +DG+ C +++ SC +
Sbjct: 280 GKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANN 339
Query: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECL 593
GC H C + +C C GY L D +TC D C A C+ +C N+ Y C C
Sbjct: 340 GGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDC-ADSPCCQQVCTNNPGGYECGCY 398
Query: 594 EGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGP 653
G+RL+ DG C D C S+ GCEH C N S+ C C G+ L ED R C E
Sbjct: 399 AGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPM 458
Query: 654 IDL 656
+DL
Sbjct: 459 VDL 461
Score = 239 bits (610), Expect = 9e-63
Identities = 143/446 (32%), Positives = 198/446 (44%), Gaps = 44/446 (9%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS- 300
C T C H C+N PGSY+C CK G+ L++D TC + CA+ + C+ CV + +
Sbjct: 165 CRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITR 224
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 360
CQC G+ L EDG+ CV CA+ N C H C G C+CH G+ L D K C
Sbjct: 225 HRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE 284
Query: 361 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRI-----NYCALNKPGCEH 415
+D CA+ C H C+NT S+ C C G+ L D + C RI N C N GC H
Sbjct: 285 DVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSH 344
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLI 475
C + C C RGY LD + +TC VD CA C+Q+C N + C C G+ +
Sbjct: 345 GCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSP-CCQQVCTNNPGGYECGCYAGYRL 403
Query: 476 NEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
+ D C VD C S GCE+ C N+ SF C C G+ L D + C+ L+ + G
Sbjct: 404 SADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDG 463
Query: 536 -------CEHSCVSSEDSFVCQCFEGYILREDGK--------TCRRKDVC--QAIDHGCE 578
H V ++ + Q F+ + D + T K VC + H C
Sbjct: 464 ELPFVRPLPHIAVLQDE--LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCS 521
Query: 579 HICVNSDDSYT-------CECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGN---- 627
C + + T C+C EG+ + C K+ C C N G
Sbjct: 522 LTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCS--CQNGGTCDSV 579
Query: 628 SYICKCSEGFVLAEDGRRCKK-CTEG 652
+ C+C G G C+ C +G
Sbjct: 580 TGACRCPPGV----SGTNCEDGCPKG 601
Score = 97.8 bits (242), Expect = 4e-20
Identities = 127/514 (24%), Positives = 160/514 (31%), Gaps = 137/514 (26%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
C C N PG Y C C GY L++D C D CA CE C N+ GSF C C +G
Sbjct: 382 CQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAG 441
Query: 309 YALAEDGKRC----------------------VAV------------------------- 321
Y L ED + C +AV
Sbjct: 442 YRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRG 501
Query: 322 DYCASENHGCEHECVNADGSYLCQ-CHEGFA--LNPDKKTCTKIDYCASSNHGCQHECVN 378
++ +E C + D S C C G L D C + N C +
Sbjct: 502 EHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFG 561
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG--CEHECVNMEESYYCR--------- 427
+ S+SC C G T + CR C G CE C +CR
Sbjct: 562 KNCSFSCSCQNGGTCDSVTGACR----CPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRG 617
Query: 428 -CHRGY---TLDPN---------------GKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ 468
CHR Y DP G CS C Q Q C + S C
Sbjct: 618 RCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPH---TQSCDKRDGS--CS 672
Query: 469 CSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKL-- 526
C GF R + C CE AC CP G S C K
Sbjct: 673 CKAGF----------RGERCQAE---CELGYFGPGCWQACTCPVGVACDSVSGECGKRCP 719
Query: 527 ---------DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDV-------- 569
C +G G S S C G G+T +
Sbjct: 720 AGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWG 779
Query: 570 --CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEH--ICV 623
CQ I C+H ++ C CL GF G RC +DVC + +G C+ C
Sbjct: 780 LGCQEICPACQHAARCDPETGACLCLPGF----VGSRC--QDVCPAGWYGPSCQTRCSCA 833
Query: 624 NNGNSY----ICKCSEGFVLAEDGRRCKKCTEGP 653
N+G+ + C C+ G+ R C GP
Sbjct: 834 NDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGP 867
Score = 68.6 bits (166), Expect = 3e-11
Identities = 107/456 (23%), Positives = 154/456 (33%), Gaps = 99/456 (21%)
Query: 249 CAH--FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCY 306
C H C ++ G+ C C G+ T C +C C N C
Sbjct: 919 CQHGAACDHVSGA--CTCPAGW----RGTFCEHACPAGFFGLDCRSAC-NCTAGAACDAV 971
Query: 307 SGYALAEDGKRCV-AVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC------ 359
+G L G+R + C + +G H C A C C G + +P C
Sbjct: 972 NGSCLCPAGRRGPRCAETCPAHTYG--HNCSQA-----CACFNGASCDPVHGQCHCAPGW 1024
Query: 360 ---TKIDYCASSNHG--CQHECV----NTDDSYS--CHCLKGFTLNPDKKTC--RRINYC 406
+ + C + +G C+H C+ T D S C C +G+ +K C R +
Sbjct: 1025 MGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAG 1084
Query: 407 ALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR---VDHCAQQDHGCEQLCLNTED 463
+ GC + + + C C G+T D C R + CAQ+ C
Sbjct: 1085 CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQR-CSCPPGAACHHV 1143
Query: 464 SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC----VNMDRSFACQCP-EGHVLRS 518
+ C+C GF + GCE +C D + CQCP E
Sbjct: 1144 TGACRCPPGF-----------------TGSGCEQACPPGSFGEDCAQMCQCPGENPACHP 1186
Query: 519 DGKTCAKLDSCALGDH---------------GCEHSC------VSSEDSFVCQCFEGYIL 557
TC SCA G H GCE C + C+C G++
Sbjct: 1187 ATGTC----SCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLG 1242
Query: 558 REDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK---RCRRKDVCKST 614
+ TC + C H+C C+ + G L G+ RC R
Sbjct: 1243 TDCNLTCPQ----GRFGPNCTHVC-GCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRF 1297
Query: 615 HHGCEHICVNNGNSYICKCSEGFV---LAEDGRRCK 647
GCEH C + N +C S G L GR C+
Sbjct: 1298 GVGCEHTC-SCRNGGLCHASNGSCSCGLGWTGRHCE 1332
Score = 65.9 bits (159), Expect = 2e-10
Identities = 118/516 (22%), Positives = 165/516 (31%), Gaps = 145/516 (28%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQ---------TTCRIQDLCAMEDH---- 288
C + C H P + C C G++ + Q +C+ + CA + H
Sbjct: 782 CQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPA 841
Query: 289 --------------------------NCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
+C C G C SG L E G +
Sbjct: 842 TGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCE 901
Query: 323 YCASENH---GCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG--CQHEC- 376
+ H GCE CQC G A + CT C + G C+H C
Sbjct: 902 QQCPQGHFGPGCEQR---------CQCQHGAACDHVSGACT----CPAGWRGTFCEHACP 948
Query: 377 ---VNTDDSYSCHCLKGFTLNPDKKTC-----RRINYCALNKPG--CEHECVNMEESYYC 426
D +C+C G + +C RR CA P H C S C
Sbjct: 949 AGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNC-----SQAC 1003
Query: 427 RCHRGYTLDPNGKTCSRVDHCAQQDHG--CEQLCL------NTEDSFVCQ---------- 468
C G + DP C HCA G C Q C N S +CQ
Sbjct: 1004 ACFNGASCDPVHGQC----HCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSG 1059
Query: 469 ---CSEGFLINEDLKTCSRVDYCLLSDHGCEYS--CVN----MDRSFACQCPEGHV---- 515
C EG+ K C D GC +S C+N + C CP G
Sbjct: 1060 HCACPEGWAGLACEKECLPRDV----RAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKC 1115
Query: 516 ----LRS-DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
LR G+ CA+ SC G C H + C+C G+ G C +
Sbjct: 1116 QSPCLRGWFGEACAQRCSCPPG-AACHHV------TGACRCPPGF----TGSGCEQACPP 1164
Query: 571 QAIDHGCEHICVNSDD-------SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHI-- 621
+ C +C + + TC C G+ G C+++ GCE +
Sbjct: 1165 GSFGEDCAQMCQCPGENPACHPATGTCSCAAGYH----GPSCQQRCPPGRYGPGCEQLCG 1220
Query: 622 CVNNGN----SYICKCSEGFVLAEDGRRCKKCTEGP 653
C+N G+ + C+C GF+ + C + GP
Sbjct: 1221 CLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGP 1256
Score = 55.1 bits (131), Expect = 3e-07
Identities = 104/427 (24%), Positives = 132/427 (30%), Gaps = 101/427 (23%)
Query: 259 SYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
S+ C C+ G +S CR + NCE C GY GK C
Sbjct: 565 SFSCSCQNGGTCDSVTGACRCPP--GVSGTNCED-----------GCPKGYY----GKHC 607
Query: 319 VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
CA N G H A C C G TC + GC EC
Sbjct: 608 RKKCNCA--NRGRCHRLYGA-----CLCDPGLYGRFCHLTCPPWAF----GPGCSEEC-- 654
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY-------CRCHRG 431
C++ T + DK+ C+ EC E Y+ C C G
Sbjct: 655 -------QCVQPHTQSCDKRDGSCSCKAGFRGERCQAEC---ELGYFGPGCWQACTCPVG 704
Query: 432 YTLDPNGKTCSRVDHCAQQDHGCEQLC----LNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
D C + Q C Q C S C C G + C
Sbjct: 705 VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCG-GAPCHGVTGQCR---- 759
Query: 488 CLLSDHG--CEYSCVNMDRSFACQ--CPE-GHVLRSDGKTCAKL-----------DSCAL 531
C G CE C CQ CP H R D +T A L D C
Sbjct: 760 CPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPA 819
Query: 532 GDHG--CEHSCVSSEDSFV------CQCFEGYILREDGKTCRRKDVCQAIDHG--CEHIC 581
G +G C+ C + D C C G+ G +C+R C G C H C
Sbjct: 820 GWYGPSCQTRCSCANDGHCHPATGHCSCAPGWT----GFSCQR--ACDTGHWGPDCSHPC 873
Query: 582 VNSDDSYTCECLEGFRLAED---GKRCRRKDVCKSTHHG--------CEHICVNNGNSYI 630
S +C+ + G L E G RC ++ C H G C+H + S
Sbjct: 874 NCSAGHGSCDAISGLCLCEAGYVGPRCEQQ--CPQGHFGPGCEQRCQCQHGAACDHVSGA 931
Query: 631 CKCSEGF 637
C C G+
Sbjct: 932 CTCPAGW 938
Score = 53.5 bits (127), Expect = 9e-07
Identities = 87/355 (24%), Positives = 111/355 (31%), Gaps = 82/355 (23%)
Query: 257 PGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF------VCQCYSGYA 310
P + C C GY S Q C CEQLC + G C+C +G+
Sbjct: 1186 PATGTCSCAAGYHGPSCQQRCPP----GRYGPGCEQLCGCLNGGSCDAATGACRCPTGFL 1241
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCAS--S 368
G C N C + +++C C +G A +P TC A
Sbjct: 1242 ----GTDC---------NLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRC 1288
Query: 369 NHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG--CEHEC----VNMEE 422
GC ++C C G + +C C L G CE C
Sbjct: 1289 ERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCS----CGLGWTGRHCELACPPGRYGAAC 1344
Query: 423 SYYCRCHRGYTLDPNGKTC--------SRVDH-CAQQDH--GCEQLCLNTED------SF 465
C CH T +P TC +H C H GC+ LC S
Sbjct: 1345 HLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISG 1404
Query: 466 VCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQ-------CPEGHVLRS 518
C C GF + + C + GC C + D C CP G
Sbjct: 1405 RCLCPAGFHGHFCERGCEPGSF----GEGCHQRC-DCDGGAPCDPVTGLCLCPPGR---- 1455
Query: 519 DGKTCAKLDSCALGDHG--------CEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
G TC LD C G G C S C C +GY+ G TCR
Sbjct: 1456 SGATC-NLD-CRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYM----GPTCR 1504
>gi|4505111 matrilin 1, cartilage matrix protein [Homo sapiens]
Length = 496
Score = 246 bits (629), Expect = 5e-65
Identities = 137/332 (41%), Positives = 191/332 (57%), Gaps = 63/332 (18%)
Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG----PIDLVFVI 660
C D+C + H CE +C+++ SY C C EGF L DG+ C C+ G DLVF+I
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLI 280
Query: 661 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 720
DGSKS+ ENFE+VK+F++ I+D+L +S K A+VGL+QYS+ V EF L F++ KD+K
Sbjct: 281 DGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKA 340
Query: 721 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 780
AV +M YM KG+MTG ALK++ + SFT GARP + +V IVFTDGR+QD +++ A
Sbjct: 341 AVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKV---GIVFTDGRSQDYINDAAK 397
Query: 781 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 840
KAK G M+AVGVG A+E+EL+EIASEP +H FY DF T+++I +KL+K IC
Sbjct: 398 KAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKIC----- 452
Query: 841 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 900
EED C CE
Sbjct: 453 --------------------------VEED-------------------------PCACE 461
Query: 901 NLIMFQNLANEEVRKLTQRLEEMTQRMEALEN 932
+L+ FQ ++ LT++LE +++R+ LEN
Sbjct: 462 SLVKFQAKVEGLLQALTRKLEAVSKRLAILEN 493
Score = 243 bits (619), Expect = 8e-64
Identities = 126/273 (46%), Positives = 179/273 (65%), Gaps = 21/273 (7%)
Query: 8 CFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRS 67
C LL+L Q + P A + SRG RT P DLVF++DSSRS
Sbjct: 12 CSLLLLLQALCSPGLAPQ-------SRGHLCRTRP-------------TDLVFVVDSSRS 51
Query: 68 VNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRM 127
V ++ KVK F+ +++ LD+GP+ TRVG++ Y STVK EFSL+ K+ + +AV+R+
Sbjct: 52 VRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRI 111
Query: 128 RHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDT 187
+ LSTGTMTGLAIQ+A+ AF +AEG R ++ +V+++VTDGRPQDSV +V+A+AR +
Sbjct: 112 QPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARAS 171
Query: 188 GILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLC-TAHMCSTLE 246
G+ +FAIGVG VD TL+ I SEP ++HV V ++S IE L+ FQ+ C + +C+T +
Sbjct: 172 GVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGD 231
Query: 247 HNCAHFCINIPGSYVCRCKQGYILNSDQTTCRI 279
H+C CI+ PGSY C C +G+ LNSD TC +
Sbjct: 232 HDCEQVCISSPGSYTCACHEGFTLNSDGKTCNV 264
Score = 153 bits (386), Expect = 8e-37
Identities = 76/203 (37%), Positives = 125/203 (61%), Gaps = 3/203 (1%)
Query: 633 CSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAA 692
CS G G C+ P DLVFV+D S+S+ FE VK F++ +I+SL + P A
Sbjct: 22 CSPGLAPQSRGHLCRT---RPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNAT 78
Query: 693 RVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGA 752
RVG++ Y++ V EF+LR S + +AV ++ + G+MTGLA++ ++F EG
Sbjct: 79 RVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGG 138
Query: 753 RPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNK 812
R S + + IV TDGR QD V + +++A+A+G+ ++A+GVG + L++IASEP ++
Sbjct: 139 RSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDE 198
Query: 813 HLFYAEDFSTMDEISEKLKKGIC 835
H+ Y E +S ++++S K ++ C
Sbjct: 199 HVDYVESYSVIEKLSRKFQEAFC 221
Score = 147 bits (371), Expect = 5e-35
Identities = 74/181 (40%), Positives = 113/181 (62%), Gaps = 3/181 (1%)
Query: 57 DLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKR 116
DLVF+ID S+SV ++ VK+FI I+ LD+ + +VGL+QY S+V+ EF L F
Sbjct: 275 DLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHT 334
Query: 117 KSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDS 176
K +++ AV+ M ++ GTMTG A++Y ++ +F+ + GARP +V ++ TDGR QD
Sbjct: 335 KKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARP---GAQKVGIVFTDGRSQDY 391
Query: 177 VAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKL 236
+ + A KA+D G +FA+GVG + L+ I SEP +H F A+F I + QKK+
Sbjct: 392 INDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKI 451
Query: 237 C 237
C
Sbjct: 452 C 452
Score = 62.8 bits (151), Expect = 1e-09
Identities = 24/42 (57%), Positives = 29/42 (69%)
Query: 318 CVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
CV D CA+ +H CE C+++ GSY C CHEGF LN D KTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
Score = 58.9 bits (141), Expect = 2e-08
Identities = 23/42 (54%), Positives = 26/42 (61%)
Query: 523 CAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC 564
C D CA GDH CE C+SS S+ C C EG+ L DGKTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
Score = 54.3 bits (129), Expect = 5e-07
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 3/49 (6%)
Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA 407
C D CA+ +H C+ C+++ SY+C C +GFTLN D KTC N C+
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC---NVCS 266
Score = 53.9 bits (128), Expect = 7e-07
Identities = 21/43 (48%), Positives = 28/43 (65%)
Query: 441 CSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
C D CA DH CEQ+C+++ S+ C C EGF +N D KTC+
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCN 263
Score = 50.1 bits (118), Expect = 1e-05
Identities = 20/42 (47%), Positives = 23/42 (54%)
Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC 523
C D C DH CE C++ S+ C C EG L SDGKTC
Sbjct: 221 CVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTC 262
Score = 47.8 bits (112), Expect = 5e-05
Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY 432
Q E V+ +SYS ++ + + C + CA CE C++ SY C CH G+
Sbjct: 196 QDEHVDYVESYSV--IEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGF 253
Query: 433 TLDPNGKTCS 442
TL+ +GKTC+
Sbjct: 254 TLNSDGKTCN 263
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 245 bits (625), Expect = 2e-64
Identities = 140/396 (35%), Positives = 188/396 (47%), Gaps = 14/396 (3%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GSY C C G+ L+ + + C + C + H C CVN+ G + C C GY
Sbjct: 1129 CHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHS 1188
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
D CV +D C+ N GCE C N++GSY C C GFAL PD+++CT ID C + +
Sbjct: 1189 TPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNI 1248
Query: 372 CQ-HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRCH 429
C +C N Y C C GF + D KTC +N C LN C C N + S+ C C
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCD 1308
Query: 430 RGYTLDPNGKT-CSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVD 486
GY+ GKT C+ ++ C H C +C NT SF C CS G+ I + +K C+ +D
Sbjct: 1309 MGYS-GKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW-IGDGIK-CTDLD 1365
Query: 487 YCLLSDHGCEY--SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSS 543
C H C C N S+ C C EG+ DG TC LD C+ + C + C+++
Sbjct: 1366 ECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSENLNLCGNGQCLNA 1423
Query: 544 EDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGK 603
+ C+C G++ DGK C D C + C N + CEC G+ L G
Sbjct: 1424 PGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGG 1483
Query: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVL 639
C + C CVN SYIC C F L
Sbjct: 1484 NCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL 1519
Score = 240 bits (612), Expect = 5e-63
Identities = 137/441 (31%), Positives = 204/441 (46%), Gaps = 44/441 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL---CVNVPGSFVCQC 305
CA C+N GSY C+C GY+L D+ C+ +D C H+C + C N+ G+++C C
Sbjct: 2217 CAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCIC 2276
Query: 306 YSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC--TKI 362
GY DG+ CV + C ++ CE+ C+N GSY C+C++GF +P++ C +
Sbjct: 2277 GPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNRE 2336
Query: 363 DYCASS--NHGCQHECVNTDD--SYSCHCLKGFTLNPD------------KKTCRR---- 402
YC + + CQ N + C C G P KK C
Sbjct: 2337 GYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGF 2396
Query: 403 ------INYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE 455
I+ C + C + ECVN SY+C C GYT D G +C ++ C Q C
Sbjct: 2397 MTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCN 2456
Query: 456 QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEG-- 513
+C NTE S+ C C +G+++ ED ++C +D C H C++ CVN F C+CP G
Sbjct: 2457 FICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFT 2516
Query: 514 --HVLRSDGKTC-AKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC 570
H D C + ++ C G + C ++ SF C+C G+ L + G +C D C
Sbjct: 2517 QHHTSCIDNNECTSDINLC-----GSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDEC 2571
Query: 571 QAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
+ +H C+H C N Y C C +G+ +C ++ C S H C N SY
Sbjct: 2572 EG-NHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYK 2630
Query: 631 CKCSEGFVLAEDGRRCKKCTE 651
C C GF + C+ E
Sbjct: 2631 CMCPAGFQYEQFSGGCQDINE 2651
Score = 214 bits (546), Expect = 2e-55
Identities = 143/445 (32%), Positives = 200/445 (44%), Gaps = 53/445 (11%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
CIN GSY C CK GY S C ++ C + C C++ GSF C C++G+
Sbjct: 1824 CINTAGSYRCDCKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKT 1882
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
+D C+ ++ C + G C N GS+ C+C+ GF L+ + C +D CAS N
Sbjct: 1883 NDDQTMCLDINECERDACG-NGTCRNTIGSFNCRCNHGFILSHNND-CIDVDECASGNGN 1940
Query: 372 -CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRC 428
C++ +C+NT S+ C C +G+ + PD +TC IN C L C C N++ SY C C
Sbjct: 1941 LCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCIC 2000
Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS--RV 485
GY+L + C +D C ++ C C NTE SF C C EGF ++ + C R+
Sbjct: 2001 PPGYSLQ--NEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRM 2058
Query: 486 DYCLLSDHG----------------------------CEYSCVNMDRSFACQCPEGH-VL 516
YC G CE D +F CP G ++
Sbjct: 2059 SYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGII 2118
Query: 517 RSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
+ +D C D C+H C++++ S+ C+C GYIL G C D C +
Sbjct: 2119 VGPDDSAVDMDECKEPDV-CKHGQCINTDGSYRCECPFGYILA--GNECVDTDECSVGNP 2175
Query: 576 GCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDV--CKSTHHGCEHICVNNGNSYICKC 633
C N + C C EGF E G +D+ C C CVN SY CKC
Sbjct: 2176 CGNGTCKNVIGGFECTCEEGF---EPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKC 2232
Query: 634 SEGFVLAEDGRRCK---KCTEGPID 655
G+VL ED R CK +C EG D
Sbjct: 2233 PVGYVLREDRRMCKDEDECEEGKHD 2257
Score = 214 bits (546), Expect = 2e-55
Identities = 144/498 (28%), Positives = 218/498 (43%), Gaps = 100/498 (20%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
C + + C+H CI+ GS+ C C G+ N DQT C D+ E C C N G
Sbjct: 1853 CQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCL--DINECERDACGNGTCRNTIG 1910
Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHG-CEH-ECVNADGSYLCQCHEGFALNPDKK 357
SF C+C G+ L+ + C+ VD CAS N C + +C+N GS+ CQC+EG+ + PD +
Sbjct: 1911 SFNCRCNHGFILSHNND-CIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR 1969
Query: 358 TCTKIDYCASSNHGC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE-H 415
TC I+ C C C N D SY C C G++L +K C I+ C C
Sbjct: 1970 TCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEK--CEDIDECVEEPEICALG 2027
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCS--RVDHCAQQDHG-------------------- 453
C N E S+ C C G++L +G+ C R+ +C + G
Sbjct: 2028 TCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCAL 2087
Query: 454 --------CEQLCLNTEDSF--VCQCSEGFLINE-----DLKTCSRVDYCLLSDHGCEYS 498
CE +++F +C G ++ D+ C D C HG
Sbjct: 2088 KGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVC---KHG---Q 2141
Query: 499 CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGD---HG-------------------- 535
C+N D S+ C+CP G++L G C D C++G+ +G
Sbjct: 2142 CINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPG 2199
Query: 536 -----------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC- 577
C CV++ S+ C+C GY+LRED + C+ +D C+ H C
Sbjct: 2200 PMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCT 2259
Query: 578 --EHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEH-ICVNNGNSYICKCS 634
+ C N +Y C C G++ DG+ C ++ C++ CE+ C+N SY C+C+
Sbjct: 2260 EKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECN 2319
Query: 635 EGFVLAEDGRRCKKCTEG 652
+GF + + C EG
Sbjct: 2320 DGFTASPNQDECLDNREG 2337
Score = 199 bits (506), Expect = 1e-50
Identities = 130/455 (28%), Positives = 188/455 (41%), Gaps = 49/455 (10%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPGS 300
CS + C FC N GSY C C+ G+ L DQ +C D C + C+ C N+PG
Sbjct: 1201 CSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGE 1260
Query: 301 FVCQCYSGYALAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQCHEGFALNPDKKTC 359
+ C CY G+ +ED K CV V+ C + C C N GS++C C G++ K C
Sbjct: 1261 YRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGC 1320
Query: 360 TKIDYCASSNHGCQHE--CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-- 415
T I+ C H C C NT S+ C C G+ D C ++ C+ C
Sbjct: 1321 TDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHA 1378
Query: 416 ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGFL 474
+C N SY C C GYT D G TC+ +D C++ + C CLN + C+C GF+
Sbjct: 1379 DCKNTMGSYRCLCKEGYTGD--GFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFV 1436
Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
+ D K C +D C L + +C N+ F C+C G+ L G C ++ C
Sbjct: 1437 PSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTT 1496
Query: 535 GCEHSCVSSEDSFVCQCFEGYILR----------------------EDGKTCRRKDVCQA 572
+CV++ S++C C + L ++G T ++
Sbjct: 1497 CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVG 1556
Query: 573 IDHG-------------CEHICVNSDDSYTCECL--EGFRLAEDGKRCRRKDVCKSTHHG 617
+ CE + Y C EGFR D C+
Sbjct: 1557 VSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGL 1616
Query: 618 CE-HICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
C+ C+N S+ C+C G+ L ED R C E
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651
Score = 184 bits (468), Expect = 3e-46
Identities = 132/476 (27%), Positives = 194/476 (40%), Gaps = 66/476 (13%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTC--RIQDLC--AMEDHNCE----------QLCVNVP 298
C N PGS++C C L+ +T C I+ C + D CE Q C ++
Sbjct: 821 CKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLG 880
Query: 299 GSF-----VCQ----CYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQCHE 348
++ +CQ C GY+ + G +C +D C C++ CVN GS+ CQC
Sbjct: 881 AAWGSPCTLCQVDPICGKGYSRIK-GTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPS 939
Query: 349 GFALNPDKKTCTKI------------------------DYCASS------NHGCQHECVN 378
G L+ + C I D C S C+ +
Sbjct: 940 GMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMR 999
Query: 379 TDDSYSCHCLKG-----FTLNPDKKTCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGY 432
Y C +G + K + IN C + C H +C N S+ CRC G+
Sbjct: 1000 NTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGF 1059
Query: 433 TLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLIN-EDLKTCSRVDYCLL 490
LD + C+ +D C C + C+NT F C+C EG+ +K C +D C
Sbjct: 1060 ALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQR 1119
Query: 491 SDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFV 548
C C N + S+ C+CP GH L + C ++ C L H C + CV+ +
Sbjct: 1120 DPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQ 1179
Query: 549 CQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRK 608
C C GY D C D C ++ GCE C NS+ SY C C GF L D + C
Sbjct: 1180 CACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDI 1239
Query: 609 DVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGS 663
D C+ + C+ C N Y C C +GF+ +ED + C E ++ + G+
Sbjct: 1240 DECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGT 1295
Score = 184 bits (466), Expect = 4e-46
Identities = 128/464 (27%), Positives = 190/464 (40%), Gaps = 54/464 (11%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
C N GS++C C GY +T C + C + HNC + +C N GSF C C G+
Sbjct: 1296 CENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI 1355
Query: 311 LAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
DG +C +D C++ H C +C N GSY C C EG+ D TCT +D C+ +
Sbjct: 1356 --GDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT--GDGFTCTDLDECSEN 1411
Query: 369 NHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCR 427
+ C + +C+N Y C C GF + D K C I+ C+L C N+ + C
Sbjct: 1412 LNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCE 1471
Query: 428 CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTC--SRV 485
C GY LD +G C+ V+ C C+NT S++C C F +N C +R
Sbjct: 1472 CEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRS 1531
Query: 486 DYCLL-----SDHG----------------------------CEYSCVNMDRSFACQCPE 512
C L D+G CE + CP
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPG 1591
Query: 513 GHVLRSDGKT--CAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCRRKDV 569
G R + T +D C C+ C+++ SF C+C GY L ED + C +
Sbjct: 1592 GEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651
Query: 570 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRC--RRKDVCKSTHHG----CEHICV 623
C+ C N+ +YTC C + G C R+ +C ++ C+ +
Sbjct: 1652 CETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELL 1711
Query: 624 NNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLG 667
N +C CS A + + C++C D + GS+ G
Sbjct: 1712 FNMTKKMCCCSYNIGRAWN-KPCEQCPIPSTDEFATLCGSQRPG 1754
Score = 182 bits (462), Expect = 1e-45
Identities = 135/435 (31%), Positives = 190/435 (43%), Gaps = 66/435 (15%)
Query: 290 CEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQC 346
CE +C+N+ GSF C+C G+ + C +D C + C+ EC+N GSY C C
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN-GPVCQRNAECINTAGSYRCDC 1835
Query: 347 HEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINY 405
G+ + C + C + C H +C++T S+ C C GF N D+ C IN
Sbjct: 1836 KPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINE 1894
Query: 406 CALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG-CEQ-LCLNTED 463
C + G C N S+ CRC+ G+ L N C VD CA + C C+NT
Sbjct: 1895 CERDACG-NGTCRNTIGSFNCRCNHGFILSHN-NDCIDVDECASGNGNLCRNGQCINTVG 1952
Query: 464 SFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKT 522
SF CQC+EG+ + D +TC ++ CLL C +C N+D S+ C CP G+ L+++
Sbjct: 1953 SFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE--K 2010
Query: 523 CAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILREDGKTCR--RKDVCQAIDHG--- 576
C +D C C +C ++E SF C C EG+ L G+ C+ R C A G
Sbjct: 2011 CEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKC 2070
Query: 577 -------------------------CEHICVNSDDSYTCECLEGFRL-------AEDGKR 604
CE D+++ C G + A D
Sbjct: 2071 SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130
Query: 605 CRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE-------GPIDLV 657
C+ DVCK HG C+N SY C+C G++LA G C E G
Sbjct: 2131 CKEPDVCK---HG---QCINTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCK 2182
Query: 658 FVIDGSKSLGEENFE 672
VI G + EE FE
Sbjct: 2183 NVIGGFECTCEEGFE 2197
Score = 177 bits (450), Expect = 3e-44
Identities = 98/300 (32%), Positives = 143/300 (47%), Gaps = 15/300 (5%)
Query: 261 VCRCKQGYILN-SDQTTCR-IQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC 318
+C +G++ N +D C+ I D+C + CVN GS+ C C +GY G C
Sbjct: 2389 LCPHGRGFMTNGADIDECKVIHDVCRNGE------CVNDRGSYHCICKTGYTPDITGTSC 2442
Query: 319 VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
V ++ C C C N +GSY C C +G+ L D ++C +D CA+ H CQ CVN
Sbjct: 2443 VDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVN 2502
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCA--LNKPGCEHECVNMEESYYCRCHRGYTLDP 436
T ++C C GFT + +C N C +N G + C N S+ C C RG++LD
Sbjct: 2503 TIGGFTCKCPPGFTQH--HTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQ 2560
Query: 437 NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
G +C VD C + +H C+ C N + C C +G+L + C + CL S H C
Sbjct: 2561 TGSSCEDVDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECL-SAHICG 2618
Query: 497 -YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGY 555
SC N S+ C CP G C ++ C C + C ++E ++C C GY
Sbjct: 2619 GASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 176 bits (445), Expect = 1e-43
Identities = 116/384 (30%), Positives = 167/384 (43%), Gaps = 37/384 (9%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE-QLCVNVPG 299
C + + C + CI PGS C C +G+ L+ + C D C E + C C+N G
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDL-RGECIDVDEC--EKNPCAGGECINNQG 509
Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKT 358
S+ CQC +GY C +D C C + C+N DGS+ C C+ GF + D K
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN 569
Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECV 418
C +D C+ N C+N D S+ C C GF L D + C+ IN C CV
Sbjct: 570 CEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCV 629
Query: 419 NMEESYYCRCHRGYTLDPNGKTC------------SRVDHCAQQDHGC----EQLCLNTE 462
N + SY C C G + +G+ C + C + G E C +TE
Sbjct: 630 NTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTE 689
Query: 463 DSF--VCQCSEGFLINEDLKTCSR----------VDYCLLSDHGCEYS-CVNMDRSFACQ 509
+F CQ E CS ++ C L C C N+ ++ C
Sbjct: 690 YAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCI 749
Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
C G+ + S GK C ++ C L C++ C ++ SFVC C +G+I + D KTC D
Sbjct: 750 CNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDID 809
Query: 569 VCQAIDHGCEHICVNSDDSYTCEC 592
C++ +C NS S+ CEC
Sbjct: 810 ECES-SPCINGVCKNSPGSFICEC 832
Score = 172 bits (436), Expect = 1e-42
Identities = 114/406 (28%), Positives = 177/406 (43%), Gaps = 35/406 (8%)
Query: 279 IQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVN 337
+ D C + + C+ C+ PGS C+C G+ L G+ C+ VD C +N EC+N
Sbjct: 449 VTDYCQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGE-CIDVDEC-EKNPCAGGECIN 506
Query: 338 ADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPD 396
GSY CQC G+ + C ID C + C + C+NTD S+ C C GF + D
Sbjct: 507 NQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRD 566
Query: 397 KKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ 456
K C ++ C++ C+N + S+ C C G+ L +G+ C ++ C
Sbjct: 567 GKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNG 626
Query: 457 LCLNTEDSFVCQCSEGFLINEDLKTC------------SRVDYCLLSDHGC----EYSCV 500
C+NT+ S+ C+C G + D + C + C+ G E C
Sbjct: 627 RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCA 686
Query: 501 NMDRSFA--CQ-CP-----EGHVLRSDG----KTCAKLDSCALGDHGCEHS-CVSSEDSF 547
+ + +F CQ CP E L S G + ++ CAL C + C + ++
Sbjct: 687 STEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTY 746
Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCR 606
C C GY + GK C + C C++ C N+ S+ C C +GF D K C
Sbjct: 747 KCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCE 806
Query: 607 RKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEG 652
D C+S+ +C N+ S+IC+CS L C + +G
Sbjct: 807 DIDECESS-PCINGVCKNSPGSFICECSSESTLDPTKTICIETIKG 851
Score = 157 bits (398), Expect = 3e-38
Identities = 117/442 (26%), Positives = 170/442 (38%), Gaps = 65/442 (14%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C+N PG Y C C G++ ++D C D C++ + C N+PG F C+C GY L
Sbjct: 1420 CLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELD 1479
Query: 313 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGC 372
G C V+ C CVN GSY+C C F LNP + C + + C
Sbjct: 1480 RSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVD-----TRSGNC 1534
Query: 373 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCEH-ECVNMEESYYCRC 428
+ D+ C + K +C C+L K CE VN E Y C
Sbjct: 1535 YLDIRPRGDNGDTACSNEIGVGVSKASC----CCSLGKAWGTPCEMCPAVNTSE-YKILC 1589
Query: 429 HRGYTLDPNGKT--CSRVDHCAQQDHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
G PN T +D C + C+ C+NT SF C+C G+ +NED + C V
Sbjct: 1590 PGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDV 1649
Query: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTC---------------------- 523
+ C +C N ++ C CP ++ + G C
Sbjct: 1650 NECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGE 1709
Query: 524 ------AKLDSCALG-----DHGCEHSCVSSEDSFVCQCFE---GYILREDGKTCRRKDV 569
K+ C+ + CE + S D F C G+++ D
Sbjct: 1710 LLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDE 1769
Query: 570 CQAIDHGCEH-ICVNSDDSYTCECLEGF------RLAEDGKRCRRKDVCKSTHHGCEHIC 622
C+ I CE+ +C+N S+ CEC GF + ED C+ VC+ C
Sbjct: 1770 CREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE-----C 1824
Query: 623 VNNGNSYICKCSEGFVLAEDGR 644
+N SY C C G+ G+
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTGQ 1846
Score = 156 bits (394), Expect = 1e-37
Identities = 77/234 (32%), Positives = 107/234 (45%), Gaps = 5/234 (2%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
C+ C C N GSY C C +GYIL D +C+ D CA + HNC+ LCVN G F
Sbjct: 2448 CNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGF 2507
Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPDKKTC 359
C+C G+ + C+ + C S+ + C + C N GS+ C+C GF+L+ +C
Sbjct: 2508 TCKCPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSC 2565
Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
+D C NH CQH C N Y C C +G+ + C N C C N
Sbjct: 2566 EDVDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHN 2624
Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGF 473
SY C C G+ + C ++ C C C NTE ++C C G+
Sbjct: 2625 TLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Score = 78.6 bits (192), Expect = 3e-14
Identities = 52/171 (30%), Positives = 76/171 (44%), Gaps = 11/171 (6%)
Query: 231 VFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
V K LC C+T+ H C P C++G+I N C+ D C C
Sbjct: 203 VCTKTLC----CATVGRAWGHPCEMCPAQ-PHPCRRGFIPNIRTGACQDVDECQAIPGLC 257
Query: 291 EQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHE 348
+ C+N GSF C+C +G+ L E ++C +D C++ CE EC N SY C+C
Sbjct: 258 QGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPP 317
Query: 349 GFALNPDKKTCTKID----YCASSNHGCQHECVNTDDSYSCHCLKGFTLNP 395
GF +PD C + Y A +N C ++ + C C G +P
Sbjct: 318 GFYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSP 368
Score = 77.0 bits (188), Expect = 8e-14
Identities = 77/279 (27%), Positives = 101/279 (36%), Gaps = 58/279 (20%)
Query: 387 CLKGFTLNPDKKTC-----------RRINYC---ALNKPGCEHECVNMEESYYCRCHRGY 432
C GF P+ TC R I +C +N C + +C C +GY
Sbjct: 89 CGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD--------HCLCQKGY 140
Query: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFV---CQCSEGFLINEDLKTCSRVDYCL 489
HC Q CE CLN C C+ GF + C R DY
Sbjct: 141 I----------GTHCGQPV--CESGCLNGGRCVAPNRCACTYGFTGPQ----CER-DYRT 183
Query: 490 LSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVC 549
C + + CQ + G C K CA H C
Sbjct: 184 -------GPCFTVISNQMCQG------QLSGIVCTKTLCCATVGRAWGHPCEMCPAQ-PH 229
Query: 550 QCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK 608
C G+I C+ D CQAI C+ C+N+ S+ C+C G +L E ++C
Sbjct: 230 PCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDI 289
Query: 609 DVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRC 646
D C + CE C N +SY CKC GF + DG RC
Sbjct: 290 DECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTRC 328
Score = 73.6 bits (179), Expect = 8e-13
Identities = 72/304 (23%), Positives = 104/304 (34%), Gaps = 67/304 (22%)
Query: 296 NVPGS-FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNP 354
NV GS + C G+ G +C+ C H C +GF P
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGNQCIVPI--------CRHSC-----------GDGFCSRP 97
Query: 355 DKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN--KPG 412
+ TC S C + C+ G + + D C++ Y + +P
Sbjct: 98 NMCTCPSGQIAPSCGSRSIQHC-------NIRCMNGGSCSDDHCLCQK-GYIGTHCGQPV 149
Query: 413 CEHECVN-----MEESYYC-------RCHRGYTLDP--------------NGKTCSRVDH 446
CE C+N C +C R Y P +G C++
Sbjct: 150 CESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLC 209
Query: 447 CAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY-SCVN 501
CA H CE C GF+ N C VD C C+ +C+N
Sbjct: 210 CATVGRAWGHPCEMCPAQPHP-----CRRGFIPNIRTGACQDVDECQAIPGLCQGGNCIN 264
Query: 502 MDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCE-HSCVSSEDSFVCQCFEGYILRED 560
SF C+CP GH L + C +D C+ CE C ++ S+ C+C G+ D
Sbjct: 265 TVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPD 324
Query: 561 GKTC 564
G C
Sbjct: 325 GTRC 328
Score = 39.7 bits (91), Expect = 0.013
Identities = 64/281 (22%), Positives = 97/281 (34%), Gaps = 64/281 (22%)
Query: 383 YSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCS 442
Y+ +C G+ KT N C + P C H C + G+ PN TC
Sbjct: 63 YNAYCCPGW------KTLPGGNQCIV--PICRHSCGD-----------GFCSRPNMCTCP 103
Query: 443 R---VDHCAQQD-HGCEQLCLN----TEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHG 494
C + C C+N ++D C C +G++ +C
Sbjct: 104 SGQIAPSCGSRSIQHCNIRCMNGGSCSDDH--CLCQKGYIGT----------HC--GQPV 149
Query: 495 CEYSCVNMDRSFA---CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQC 551
CE C+N R A C C G G C + D+ C + + +CQ
Sbjct: 150 CESGCLNGGRCVAPNRCACTYGFT----GPQCER-------DYRTG-PCFTVISNQMCQ- 196
Query: 552 FEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC 611
G + G C + C + H C + C GF C+ D C
Sbjct: 197 --GQL---SGIVCTKTLCCATVGRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDEC 250
Query: 612 KSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
++ C+ C+N S+ CKC G L E ++C+ E
Sbjct: 251 QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDE 291
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 238 bits (607), Expect = 2e-62
Identities = 144/446 (32%), Positives = 212/446 (47%), Gaps = 36/446 (8%)
Query: 223 SQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ 280
SQ+ T V + CT + +C A CIN+P Y C C +GY + Q C
Sbjct: 864 SQVIAPTQVTEINECTVNPDICG------AGHCINLPVRYTCICYEGYRFSEQQRKCVDI 917
Query: 281 DLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNAD 339
D C H C Q C N GSF+C C +G+ +E+G C+ VD C + E CVN
Sbjct: 918 DECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTV 977
Query: 340 GSYLCQ-CHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC-HCLKGF------ 391
G++ C+ C G+ + + C ID C + + +CVN+ SY C C +GF
Sbjct: 978 GAFRCEYCDSGYRMT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 1036
Query: 392 TLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
L+ D+ C N CA +C N+E SY C CH+GYT P+ K C +D C Q +
Sbjct: 1037 CLDVDE--CLEPNVCA------NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 1088
Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL---LSDHGCEYSCVNMDRSFAC 508
C NTE SF C C +G+ ++ C +D C L HG C N + SF C
Sbjct: 1089 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHG---QCRNTEGSFQC 1145
Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRK 567
C +G+ G C ++ C C+ C+++ S+ C C +G+ L +D KTC+
Sbjct: 1146 VCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDI 1204
Query: 568 DVCQAID-HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNN 625
+ C+ G + C+N++ S+ C C +GF ++ DG+ C D C +T C N
Sbjct: 1205 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNT 1264
Query: 626 GNSYICKCSEGFVLAEDGRRCKKCTE 651
S+ C C +GF +DG+ C E
Sbjct: 1265 AGSFRCLCYQGFQAPQDGQGCVDVNE 1290
Score = 237 bits (605), Expect = 3e-62
Identities = 137/413 (33%), Positives = 199/413 (48%), Gaps = 17/413 (4%)
Query: 233 QKKLCTAHMCSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE 291
Q+K C+ ++H C+ C N GS++C C G++ + + T C D C D E
Sbjct: 911 QRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGE 970
Query: 292 QLCVNVPGSFVCQ-CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEG 349
CVN G+F C+ C SGY + + G RC +D C + + + +CVN+ GSY C C EG
Sbjct: 971 GHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEG 1029
Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
F C +D C N +C N + SY C C KG+T PD K CR I+ C
Sbjct: 1030 F--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG 1087
Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
+C N E S+ C C +GY L C +D C + C NTE SF C C
Sbjct: 1088 NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVC 1147
Query: 470 SEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
+G+ + C ++ CL C+ C+N S+ C CP+G L D KTC ++
Sbjct: 1148 DQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINE 1206
Query: 529 CAL-GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ----AIDHGCEHICVN 583
C G G + C+++E SF C C +G+ + DG+TC D C HG C N
Sbjct: 1207 CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDN 1263
Query: 584 SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCSE 635
+ S+ C C +GF+ +DG+ C + C+ C E C N S++C C++
Sbjct: 1264 TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 1316
Score = 190 bits (482), Expect = 6e-48
Identities = 133/466 (28%), Positives = 193/466 (41%), Gaps = 74/466 (15%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C N+ GSY+C C +GY D CR D C + C N GSF C C GY L+
Sbjct: 1054 CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 1113
Query: 313 EDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
+C +D C H C H +C N +GS+ C C +G+ + C I+ C
Sbjct: 1114 AAKDQCEDIDEC-QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 1172
Query: 372 CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCR 427
CQ +C+NT SY C C GF L+ D KTC+ IN C PG + EC+N E S++C
Sbjct: 1173 CQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINEC--EHPGLCGPQGECLNTEGSFHCV 1229
Query: 428 CHRGYTLDPNGKTCSRVDHCAQQ----DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
C +G+++ +G+TC +D C HG C NT SF C C +GF +D + C
Sbjct: 1230 CQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDNTAGSFRCLCYQGFQAPQDGQGCV 1286
Query: 484 RVDYCLLSDHGC-EYSCVNMDRSFACQCP------------------------------- 511
V+ C L C E C N++ SF C C
Sbjct: 1287 DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1346
Query: 512 --EGHVLRSDGKTC--------AKLDSCALGDHGCEHSCV--------SSEDSFVCQCFE 553
E + +D C K + C G +C ++E + +C +
Sbjct: 1347 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1406
Query: 554 GYILRED------GKTCRRKDVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
G++ + G+ + D C C++ C+N+ Y C C +G +C
Sbjct: 1407 GFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC 1466
Query: 606 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
D C+ + CVN SY C C+ VL +RC + E
Sbjct: 1467 FDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1512
Score = 120 bits (300), Expect = 8e-27
Identities = 121/496 (24%), Positives = 183/496 (36%), Gaps = 110/496 (22%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
C+N GS+ C C+QG+ +++D TC D C + + C+ C N GSF C CY G+
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1277
Query: 311 LAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQC-HEGFALNP-------------- 354
+DG+ CV V+ C + C E C N +GS+LC C E +P
Sbjct: 1278 APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1337
Query: 355 --------DKKTC------------------TKIDYCASSNHGCQHEC------VNTDDS 382
+KK C TK + C +S G C V
Sbjct: 1338 VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1397
Query: 383 YSCHCLKGFTLNPDKKTCRRI---NY-----CAL-NKPGCEHE-CVNMEESYYCRCHRGY 432
++ C KG P ++ NY C L + C++ C+N Y C C +G
Sbjct: 1398 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGT 1457
Query: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-------- 484
DP C +D C + C+NTE S+ C C+ +++ K C R
Sbjct: 1458 YYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1517
Query: 485 ------VDYC---LLSDHGCEYSCVNMDRSFA-CQCPEGHVLRSDGKTCAKLDS------ 528
D C L ++ C V ++ C C G C DS
Sbjct: 1518 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQL 1577
Query: 529 CALGDHG-------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
C + G E ++ F+ F + C I +
Sbjct: 1578 CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEEC-------GILN 1630
Query: 576 GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNNGNSYI 630
GCE+ CV + YTC+C +G+ L C + C ++ C++ C+N SY
Sbjct: 1631 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1690
Query: 631 CKCSEGFVLAEDGRRC 646
C C G+V ++ C
Sbjct: 1691 CLCLPGYVPSDKPNYC 1706
Score = 74.7 bits (182), Expect = 4e-13
Identities = 71/277 (25%), Positives = 104/277 (37%), Gaps = 43/277 (15%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
FC+N Y C CKQG + + C D C + CVN GS+ C C L
Sbjct: 1441 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1500
Query: 312 AEDGKRCVAV--------------DYC---ASENHGCEHECVNADGSYL-CQCHEGFALN 353
KRC+ D C S+ + C V +Y C C G A
Sbjct: 1501 DASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWG 1560
Query: 354 PDKKTCTKIDYCASSNHG--CQHECVNTDDSYSCHCLKGFT------LNPDKKTCRRINY 405
C D S ++ C Y L F+ +P R +N
Sbjct: 1561 MQCALCPLKD---SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNS 1617
Query: 406 --------CALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG--- 453
C + GCE+ CV ++E Y C C GY LD TC V+ C + ++
Sbjct: 1618 FEELQAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSL 1676
Query: 454 CEQL-CLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL 489
C+ C+NT+ S+ C C G++ ++ C+ ++ L
Sbjct: 1677 CKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713
Score = 67.0 bits (162), Expect = 8e-11
Identities = 61/271 (22%), Positives = 99/271 (36%), Gaps = 37/271 (13%)
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
C+N + C C G +C +D C + + +CVN +GSY C C L+
Sbjct: 1442 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD 1501
Query: 354 PDKKTCTKI--------------DYC---ASSNHGCQHECVNTDDSYS-CHCLKG----- 390
+K C + D C S + C V +Y+ C CL G
Sbjct: 1502 ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1561
Query: 391 -FTLNPDKKTCRRINYCAL-----NKPGCEHECVNMEESYYCRCHRGYTLDP--NGKTCS 442
L P K + C + +P V+ E Y + D N
Sbjct: 1562 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1621
Query: 443 RVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY---- 497
+ + C + GCE C+ ++ + C C +G+ ++ TC V+ C ++
Sbjct: 1622 QAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1680
Query: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
C+N D S+ C C G+V C L++
Sbjct: 1681 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNT 1711
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/211 (27%), Positives = 89/211 (42%), Gaps = 37/211 (17%)
Query: 224 QIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYV-CRCKQGYILNSDQTTCRIQDL 282
QIE T V+Q LC H+ E+ C+ + +Y C C G C ++D
Sbjct: 1516 QIEE-TDVYQD-LCWEHLSD--EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD- 1570
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------VAVDY 323
+ QLC N+P + Q Y AL + ++ + +
Sbjct: 1571 ----SDDYAQLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEE 1625
Query: 324 CASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVN 378
C N GCE+ CV Y C C +G+ L+ K TC ++ C N+ C++ +C+N
Sbjct: 1626 CGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
TD SY C CL G+ + C +N ALN
Sbjct: 1685 TDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1714
Score = 37.0 bits (84), Expect = 0.086
Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 12/114 (10%)
Query: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
+C GY + C ++ C + EC+N GSY C C GF +P +C
Sbjct: 611 ECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 669
Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCE 414
S G + V S C+ +++ K+ C C++ K P CE
Sbjct: 670 PVISEEKGPCYRLV----SSGRQCMHPLSVHLTKQLC----CCSVGKAWGPHCE 715
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 387 CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
CL G+ + C+ IN C L EC+N SY C C G+ DP +C
Sbjct: 612 CLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665
Score = 31.6 bits (70), Expect = 3.6
Identities = 25/98 (25%), Positives = 33/98 (33%), Gaps = 17/98 (17%)
Query: 273 DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG-- 330
D C++Q +C + C+N GS+ C C G+ CV SE G
Sbjct: 626 DINECQLQGVCPNGE------CLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679
Query: 331 ---------CEHECVNADGSYLCQCHEGFALNPDKKTC 359
C H LC C G A P + C
Sbjct: 680 YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC 717
Score = 30.4 bits (67), Expect = 8.1
Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 7/121 (5%)
Query: 437 NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
N C ++ C Q CLNT S+ C C GF + +C + + G
Sbjct: 620 NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 679
Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEG 554
Y V+ R QC + + C A G H CE + +F +C G
Sbjct: 680 YRLVSSGR----QCMHPLSVHLTKQLCCCSVGKAWGPH-CEKCPLPGTAAFKEICPGGMG 734
Query: 555 Y 555
Y
Sbjct: 735 Y 735
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 238 bits (607), Expect = 2e-62
Identities = 144/446 (32%), Positives = 212/446 (47%), Gaps = 36/446 (8%)
Query: 223 SQIETLTSVFQKKLCTAH--MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ 280
SQ+ T V + CT + +C A CIN+P Y C C +GY + Q C
Sbjct: 538 SQVIAPTQVTEINECTVNPDICG------AGHCINLPVRYTCICYEGYRFSEQQRKCVDI 591
Query: 281 DLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNAD 339
D C H C Q C N GSF+C C +G+ +E+G C+ VD C + E CVN
Sbjct: 592 DECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTV 651
Query: 340 GSYLCQ-CHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC-HCLKGF------ 391
G++ C+ C G+ + + C ID C + + +CVN+ SY C C +GF
Sbjct: 652 GAFRCEYCDSGYRMT-QRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 710
Query: 392 TLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD 451
L+ D+ C N CA +C N+E SY C CH+GYT P+ K C +D C Q +
Sbjct: 711 CLDVDE--CLEPNVCA------NGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 762
Query: 452 HGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL---LSDHGCEYSCVNMDRSFAC 508
C NTE SF C C +G+ ++ C +D C L HG C N + SF C
Sbjct: 763 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHG---QCRNTEGSFQC 819
Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEH-SCVSSEDSFVCQCFEGYILREDGKTCRRK 567
C +G+ G C ++ C C+ C+++ S+ C C +G+ L +D KTC+
Sbjct: 820 VCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDI 878
Query: 568 DVCQAID-HGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNN 625
+ C+ G + C+N++ S+ C C +GF ++ DG+ C D C +T C N
Sbjct: 879 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNT 938
Query: 626 GNSYICKCSEGFVLAEDGRRCKKCTE 651
S+ C C +GF +DG+ C E
Sbjct: 939 AGSFRCLCYQGFQAPQDGQGCVDVNE 964
Score = 237 bits (605), Expect = 3e-62
Identities = 137/413 (33%), Positives = 199/413 (48%), Gaps = 17/413 (4%)
Query: 233 QKKLCTAHMCSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE 291
Q+K C+ ++H C+ C N GS++C C G++ + + T C D C D E
Sbjct: 585 QRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGE 644
Query: 292 QLCVNVPGSFVCQ-CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEG 349
CVN G+F C+ C SGY + + G RC +D C + + + +CVN+ GSY C C EG
Sbjct: 645 GHCVNTVGAFRCEYCDSGYRMTQRG-RCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEG 703
Query: 350 FALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
F C +D C N +C N + SY C C KG+T PD K CR I+ C
Sbjct: 704 F--RGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQG 761
Query: 410 KPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQC 469
+C N E S+ C C +GY L C +D C + C NTE SF C C
Sbjct: 762 NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVC 821
Query: 470 SEGFLINEDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
+G+ + C ++ CL C+ C+N S+ C CP+G L D KTC ++
Sbjct: 822 DQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQL-DDNKTCQDINE 880
Query: 529 CAL-GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ----AIDHGCEHICVN 583
C G G + C+++E SF C C +G+ + DG+TC D C HG C N
Sbjct: 881 CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDN 937
Query: 584 SDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCSE 635
+ S+ C C +GF+ +DG+ C + C+ C E C N S++C C++
Sbjct: 938 TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 990
Score = 190 bits (482), Expect = 6e-48
Identities = 133/466 (28%), Positives = 193/466 (41%), Gaps = 74/466 (15%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C N+ GSY+C C +GY D CR D C + C N GSF C C GY L+
Sbjct: 728 CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLS 787
Query: 313 EDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG 371
+C +D C H C H +C N +GS+ C C +G+ + C I+ C
Sbjct: 788 AAKDQCEDIDEC-QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 846
Query: 372 CQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC---EHECVNMEESYYCR 427
CQ +C+NT SY C C GF L+ D KTC+ IN C PG + EC+N E S++C
Sbjct: 847 CQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINEC--EHPGLCGPQGECLNTEGSFHCV 903
Query: 428 CHRGYTLDPNGKTCSRVDHCAQQ----DHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
C +G+++ +G+TC +D C HG C NT SF C C +GF +D + C
Sbjct: 904 CQQGFSISADGRTCEDIDECVNNTVCDSHG---FCDNTAGSFRCLCYQGFQAPQDGQGCV 960
Query: 484 RVDYCLLSDHGC-EYSCVNMDRSFACQCP------------------------------- 511
V+ C L C E C N++ SF C C
Sbjct: 961 DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEE 1020
Query: 512 --EGHVLRSDGKTC--------AKLDSCALGDHGCEHSCV--------SSEDSFVCQCFE 553
E + +D C K + C G +C ++E + +C +
Sbjct: 1021 KKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGK 1080
Query: 554 GYILRED------GKTCRRKDVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGKRC 605
G++ + G+ + D C C++ C+N+ Y C C +G +C
Sbjct: 1081 GFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQC 1140
Query: 606 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
D C+ + CVN SY C C+ VL +RC + E
Sbjct: 1141 FDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE 1186
Score = 120 bits (300), Expect = 8e-27
Identities = 121/496 (24%), Positives = 183/496 (36%), Gaps = 110/496 (22%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--LCVNVPGSFVCQCYSGYA 310
C+N GS+ C C+QG+ +++D TC D C + + C+ C N GSF C CY G+
Sbjct: 893 CLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQ 951
Query: 311 LAEDGKRCVAVDYCASENHGC-EHECVNADGSYLCQC-HEGFALNP-------------- 354
+DG+ CV V+ C + C E C N +GS+LC C E +P
Sbjct: 952 APQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLD 1011
Query: 355 --------DKKTC------------------TKIDYCASSNHGCQHEC------VNTDDS 382
+KK C TK + C +S G C V
Sbjct: 1012 VDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAE 1071
Query: 383 YSCHCLKGFTLNPDKKTCRRI---NY-----CAL-NKPGCEHE-CVNMEESYYCRCHRGY 432
++ C KG P ++ NY C L + C++ C+N Y C C +G
Sbjct: 1072 FTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGT 1131
Query: 433 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR-------- 484
DP C +D C + C+NTE S+ C C+ +++ K C R
Sbjct: 1132 YYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQI 1191
Query: 485 ------VDYC---LLSDHGCEYSCVNMDRSFA-CQCPEGHVLRSDGKTCAKLDS------ 528
D C L ++ C V ++ C C G C DS
Sbjct: 1192 EETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQL 1251
Query: 529 CALGDHG-------------CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDH 575
C + G E ++ F+ F + C I +
Sbjct: 1252 CNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEEC-------GILN 1304
Query: 576 GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNNGNSYI 630
GCE+ CV + YTC+C +G+ L C + C ++ C++ C+N SY
Sbjct: 1305 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1364
Query: 631 CKCSEGFVLAEDGRRC 646
C C G+V ++ C
Sbjct: 1365 CLCLPGYVPSDKPNYC 1380
Score = 74.7 bits (182), Expect = 4e-13
Identities = 71/277 (25%), Positives = 104/277 (37%), Gaps = 43/277 (15%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
FC+N Y C CKQG + + C D C + CVN GS+ C C L
Sbjct: 1115 FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVL 1174
Query: 312 AEDGKRCVAV--------------DYC---ASENHGCEHECVNADGSYL-CQCHEGFALN 353
KRC+ D C S+ + C V +Y C C G A
Sbjct: 1175 DASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWG 1234
Query: 354 PDKKTCTKIDYCASSNHG--CQHECVNTDDSYSCHCLKGFT------LNPDKKTCRRINY 405
C D S ++ C Y L F+ +P R +N
Sbjct: 1235 MQCALCPLKD---SDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNS 1291
Query: 406 --------CALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG--- 453
C + GCE+ CV ++E Y C C GY LD TC V+ C + ++
Sbjct: 1292 FEELQAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSL 1350
Query: 454 CEQL-CLNTEDSFVCQCSEGFLINEDLKTCSRVDYCL 489
C+ C+NT+ S+ C C G++ ++ C+ ++ L
Sbjct: 1351 CKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387
Score = 67.0 bits (162), Expect = 8e-11
Identities = 61/271 (22%), Positives = 99/271 (36%), Gaps = 37/271 (13%)
Query: 294 CVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALN 353
C+N + C C G +C +D C + + +CVN +GSY C C L+
Sbjct: 1116 CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD 1175
Query: 354 PDKKTCTKI--------------DYC---ASSNHGCQHECVNTDDSYS-CHCLKG----- 390
+K C + D C S + C V +Y+ C CL G
Sbjct: 1176 ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM 1235
Query: 391 -FTLNPDKKTCRRINYCAL-----NKPGCEHECVNMEESYYCRCHRGYTLDP--NGKTCS 442
L P K + C + +P V+ E Y + D N
Sbjct: 1236 QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL 1295
Query: 443 RVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEY---- 497
+ + C + GCE C+ ++ + C C +G+ ++ TC V+ C ++
Sbjct: 1296 QAEECGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNA 1354
Query: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
C+N D S+ C C G+V C L++
Sbjct: 1355 KCINTDGSYKCLCLPGYVPSDKPNYCTPLNT 1385
Score = 62.8 bits (151), Expect = 1e-09
Identities = 59/211 (27%), Positives = 89/211 (42%), Gaps = 37/211 (17%)
Query: 224 QIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYV-CRCKQGYILNSDQTTCRIQDL 282
QIE T V+Q LC H+ E+ C+ + +Y C C G C ++D
Sbjct: 1190 QIEE-TDVYQD-LCWEHLSD--EYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKD- 1244
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------VAVDY 323
+ QLC N+P + Q Y AL + ++ + +
Sbjct: 1245 ----SDDYAQLC-NIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEE 1299
Query: 324 CASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVN 378
C N GCE+ CV Y C C +G+ L+ K TC ++ C N+ C++ +C+N
Sbjct: 1300 CGILN-GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALN 409
TD SY C CL G+ + C +N ALN
Sbjct: 1359 TDGSYKCLCLPGYVPSDKPNYCTPLN-TALN 1388
Score = 37.0 bits (84), Expect = 0.086
Identities = 29/114 (25%), Positives = 45/114 (39%), Gaps = 12/114 (10%)
Query: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
+C GY + C ++ C + EC+N GSY C C GF +P +C
Sbjct: 285 ECLPGYKRVNN-TFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDP 343
Query: 364 YCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK---PGCE 414
S G + V S C+ +++ K+ C C++ K P CE
Sbjct: 344 PVISEEKGPCYRLV----SSGRQCMHPLSVHLTKQLC----CCSVGKAWGPHCE 389
Score = 36.2 bits (82), Expect = 0.15
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 387 CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTC 441
CL G+ + C+ IN C L EC+N SY C C G+ DP +C
Sbjct: 286 CLPGYK-RVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339
Score = 31.6 bits (70), Expect = 3.6
Identities = 25/98 (25%), Positives = 33/98 (33%), Gaps = 17/98 (17%)
Query: 273 DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG-- 330
D C++Q +C + C+N GS+ C C G+ CV SE G
Sbjct: 300 DINECQLQGVCPNGE------CLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353
Query: 331 ---------CEHECVNADGSYLCQCHEGFALNPDKKTC 359
C H LC C G A P + C
Sbjct: 354 YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKC 391
Score = 30.4 bits (67), Expect = 8.1
Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 7/121 (5%)
Query: 437 NGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCE 496
N C ++ C Q CLNT S+ C C GF + +C + + G
Sbjct: 294 NNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPC 353
Query: 497 YSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEG 554
Y V+ R QC + + C A G H CE + +F +C G
Sbjct: 354 YRLVSSGR----QCMHPLSVHLTKQLCCCSVGKAWGPH-CEKCPLPGTAAFKEICPGGMG 408
Query: 555 Y 555
Y
Sbjct: 409 Y 409
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 231 bits (588), Expect = 3e-60
Identities = 147/466 (31%), Positives = 201/466 (43%), Gaps = 69/466 (14%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRI----------------------------- 279
C H CIN GSY C C G+ L D TCR
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 280 ---QDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE-- 334
Q ++ C+Q+C V GS +C C+ GYA+ DG C D C H C
Sbjct: 676 PLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQF 735
Query: 335 CVNADGSYLC-----QCHEGFALNPDKKTCTKIDYCASSNHGCQ--HECVNTDDSYSCHC 387
CVN GS+ C C +G+ LN +K C I+ C + H C CVNT S+ HC
Sbjct: 736 CVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHCVNTLGSF--HC 792
Query: 388 LKGFTLNP----DKKTCRRINYCALNKPGCE--HECVNMEESYYC----RCHRGYTLDPN 437
K T P C ++ CA+ C+ C N + S+YC RC G+ DP
Sbjct: 793 YKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE 852
Query: 438 GKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ-----CSEGFLINEDLKTCSRVDYCLL 490
G C ++ C C C+NT S+ CQ C+ G+ ++D C V+ C
Sbjct: 853 G-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECET 911
Query: 491 SDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-ALGDHGCEHSCVSSEDSF 547
H C C N+ S+ C C G + G+ C ++ C A C+H+C ++ S+
Sbjct: 912 GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSY 971
Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
C C G++L DGK C + C+A C C N SY C C +G++LAEDG C
Sbjct: 972 RCSCASGFLLAADGKRCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTD 1029
Query: 608 KDVC-KSTHHGCEHICVNNGNSYICKCSE-GFVLAEDGRRCKKCTE 651
D C + C C+N SY C C E G+ + +GR CK E
Sbjct: 1030 IDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE 1075
Score = 221 bits (562), Expect = 3e-57
Identities = 143/438 (32%), Positives = 195/438 (44%), Gaps = 43/438 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVC--- 303
C C + GS +C C GY + +D +C QD C M H+C Q CVN GSF C
Sbjct: 689 CKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNH 748
Query: 304 --QCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLC----QCHEGFALNPD 355
C GY L ++CV ++ C ++ H C CVN GS+ C C G+AL
Sbjct: 749 TVLCADGYIL-NAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDG 807
Query: 356 KKTCTKIDYCASSNHGCQ--HECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALN 409
+ C +D CA H CQ C NT S+ C C+ GF +P+ C IN C
Sbjct: 808 E--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE-GNCVDINECTSL 864
Query: 410 KPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLN 460
C C+N SY C+ C RGY +G C V+ C H C Q+C N
Sbjct: 865 SEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHN 924
Query: 461 TEDSFVCQCSEGFLINEDLKTCSRVDYCLLS-DHGCEYSCVNMDRSFACQCPEGHVLRSD 519
S+ C C GF + + C V+ C S C+++C N S+ C C G +L +D
Sbjct: 925 LPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAAD 984
Query: 520 GKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVC-QAIDHGCE 578
GK C ++ C C C + S+ C C +GY L EDG TC D C Q C
Sbjct: 985 GKRCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCT 1042
Query: 579 HICVNSDDSYTCECLE-GFRLAEDGKRCRRKDVCKSTHHGCE--HICVNNGNSYIC---K 632
C+N SY C C E G+ + +G+ C+ D C H C C N S+ C +
Sbjct: 1043 FRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFE 1102
Query: 633 CSEGFVLAEDGRRCKKCT 650
C +V +C++ T
Sbjct: 1103 CPPNYVQVSK-TKCERTT 1119
Score = 207 bits (526), Expect = 5e-53
Identities = 136/438 (31%), Positives = 185/438 (42%), Gaps = 71/438 (16%)
Query: 280 QDLCAM-EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------- 318
QD C + C+ LC+N GS+ C C+ G++L +DG+ C
Sbjct: 605 QDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSE 664
Query: 319 ------------VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
+ +N C+ C GS +C C G+A+ D +C D C
Sbjct: 665 FSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECL 724
Query: 367 SSNHGCQHE--CVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALNKPGCE--HEC 417
H C CVNT S+ C C G+ LN +K C IN C + C C
Sbjct: 725 MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRGEHC 783
Query: 418 VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ--- 468
VN S++C C GY L C VD CA H C+ LC NT+ SF CQ
Sbjct: 784 VNTLGSFHCYKALTCEPGYALKDG--ECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQ 841
Query: 469 -CSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEGHVLRSDG 520
C +GFL + + C ++ C C +SC+N S+ CQ C G+ DG
Sbjct: 842 RCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDG 900
Query: 521 KTCAKLDSCALGDHGCEHS--CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAI-DHGC 577
C ++ C G H C C + S+ C C G+ G+ C + C A C
Sbjct: 901 TKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLC 960
Query: 578 EHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGF 637
+H C N+ SY C C GF LA DGKRC + C++ C C N SY C C +G+
Sbjct: 961 QHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQGY 1018
Query: 638 VLAEDGRRC---KKCTEG 652
LAEDG C +C +G
Sbjct: 1019 QLAEDGHTCTDIDECAQG 1036
Score = 178 bits (452), Expect = 2e-44
Identities = 109/315 (34%), Positives = 144/315 (45%), Gaps = 30/315 (9%)
Query: 242 CSTLEHNC--AHFCINIPGSYVC----RCKQGYILNSDQTTCRIQDLCAMEDHNCEQ--L 293
C+ H C C N GS+ C RC G++ + + I + C C
Sbjct: 815 CAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINE-CTSLSEPCRPGFS 873
Query: 294 CVNVPGSFVCQ-----CYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQC 346
C+N GS+ CQ C GY ++DG +CV V+ C + H C C N GSY C C
Sbjct: 874 CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933
Query: 347 HEGFALNPDKKTCTKIDYC-ASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINY 405
GF + + C ++ C AS CQH C NT SY C C GF L D K C +N
Sbjct: 934 KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNE 993
Query: 406 CALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDS 464
C + C EC N+ SY C C +GY L +G TC+ +D CAQ C CLN S
Sbjct: 994 CEAQR--CSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1051
Query: 465 FVCQCSE-GFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFAC---QCPEGHVLRS 518
+ C C E G+ + + ++C VD C L H C +C N+ SF C +CP +V S
Sbjct: 1052 YQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVS 1111
Query: 519 DGK----TCAKLDSC 529
K TC C
Sbjct: 1112 KTKCERTTCHDFLEC 1126
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 219 bits (559), Expect = 7e-57
Identities = 144/463 (31%), Positives = 196/463 (42%), Gaps = 67/463 (14%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRI----------------------------- 279
C H CIN GSY C C G+ L D TCR
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 280 ---QDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HE 334
Q ++ C+Q+C V GS +C C+ GYA+ DG C ++ C ++ H C
Sbjct: 676 PLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEH 735
Query: 335 CVNADGSYLC----QCHEGFALNPDKKTCTKIDYCASSNHGCQ--HECVNTDDSYSC--- 385
CVN GS+ C C G+AL + C +D CA H CQ C NT S+ C
Sbjct: 736 CVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 793
Query: 386 -HCLKGFTLNPDKKTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPN 437
C+ GF +P+ C IN C C C+N SY C+ C RGY +
Sbjct: 794 QRCMDGFLQDPE-GNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDD 852
Query: 438 GKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLS-DHG 494
G C V+ C H C Q+C N S+ C C GF + + C V+ C S
Sbjct: 853 GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRL 912
Query: 495 CEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEG 554
C+++C N S+ C C G +L +DGK C ++ C C C + S+ C C +G
Sbjct: 913 CQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQECANIYGSYQCYCRQG 970
Query: 555 YILREDGKTCRRKDVC-QAIDHGCEHICVNSDDSYTCECLE-GFRLAEDGKRCRRKDVCK 612
Y L EDG TC D C Q C C+N SY C C E G+ + +G+ C+ D C
Sbjct: 971 YQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECA 1030
Query: 613 STHHGCE--HICVNNGNSYIC---KCSEGFVLAEDGRRCKKCT 650
H C C N S+ C +C +V +C++ T
Sbjct: 1031 LGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSK-TKCERTT 1072
Score = 204 bits (518), Expect = 4e-52
Identities = 127/429 (29%), Positives = 185/429 (43%), Gaps = 62/429 (14%)
Query: 280 QDLCAM-EDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRC-------------------- 318
QD C + C+ LC+N GS+ C C+ G++L +DG+ C
Sbjct: 605 QDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSE 664
Query: 319 ------------VAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
+ +N C+ C GS +C C G+A+ D +C I+ C
Sbjct: 665 FSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECV 724
Query: 367 SSNHGCQ--HECVNTDDSYSCHCLKGFTLNP----DKKTCRRINYCALNKPGCE--HECV 418
+ H C CVNT S+ HC K T P C ++ CA+ C+ C
Sbjct: 725 TDLHTCSRGEHCVNTLGSF--HCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQ 782
Query: 419 NMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQ---- 468
N + S+YC RC G+ DP G C ++ C C C+NT S+ CQ
Sbjct: 783 NTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841
Query: 469 -CSEGFLINEDLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAK 525
C+ G+ ++D C V+ C H C C N+ S+ C C G + G+ C
Sbjct: 842 ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 901
Query: 526 LDSC-ALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNS 584
++ C A C+H+C ++ S+ C C G++L DGK C + C+A C C N
Sbjct: 902 VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEA--QRCSQECANI 959
Query: 585 DDSYTCECLEGFRLAEDGKRCRRKDVC-KSTHHGCEHICVNNGNSYICKCSE-GFVLAED 642
SY C C +G++LAEDG C D C + C C+N SY C C E G+ + +
Sbjct: 960 YGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTAN 1019
Query: 643 GRRCKKCTE 651
GR CK E
Sbjct: 1020 GRSCKDVDE 1028
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/113 (27%), Positives = 45/113 (39%), Gaps = 34/113 (30%)
Query: 577 CEHICVNSDDSYTCECLEGFRLAEDGKRCR------------------------------ 606
C+H+C+N+ SY C C GF L +DG+ CR
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 607 ---RKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
+ + CK + C+ +C G S IC C G+ + DG C+ E DL
Sbjct: 676 PLPQPNTCKD-NGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDL 727
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 218 bits (554), Expect = 3e-56
Identities = 131/403 (32%), Positives = 185/403 (45%), Gaps = 15/403 (3%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
C+N+P Y C C GY L+ Q C + C + + C+N GS+ C CY GY LA
Sbjct: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920
Query: 313 EDG--KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
G + C ++ C +C N +GSY C+C +G+ + K C I+ C
Sbjct: 921 TSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM-VRKGHCQDINECRHPGT 979
Query: 371 GCQHECVNTDDSYSC-HCLKGFTLNPDKKTCRRINYCALNKPG-CEH-ECVNMEESYYCR 427
CVN+ SY+C C +G+ +C +N C PG C H +C N+E S+ C
Sbjct: 980 CPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035
Query: 428 CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTCSRVD 486
C +GY + + K C VD CA + LCLNTE SF C C G+ +NED C +D
Sbjct: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLD 1095
Query: 487 YCLLSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC-EHSCVSSE 544
C C N SF+C+ C G+ G +C +D C C C ++
Sbjct: 1096 ECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
Query: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGK 603
S+ C C +G+ L +G C + C +H H C+NS S+ C C GF AE G
Sbjct: 1156 GSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGT 1214
Query: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
C+ D C +T CVN S+ C C GF + + C
Sbjct: 1215 SCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGEC 1257
Score = 206 bits (525), Expect = 6e-53
Identities = 134/419 (31%), Positives = 182/419 (43%), Gaps = 35/419 (8%)
Query: 253 CINIPGSYVCRCKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCY 306
C N GSY C C QGYI+ D CR C + CVN PGS+ C C
Sbjct: 945 CTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCP------DGRCVNSPGSYTCLACE 998
Query: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
GY + G CV V+ C + +C N +GS+ C C +G+ + D+K C +D CA
Sbjct: 999 EGYR-GQSGS-CVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
Query: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
S C+NT+ S++C C G+ +N D C ++ CA C N S+
Sbjct: 1057 SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFS 1116
Query: 426 CR-CHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF-----LINED 478
C+ C GY P G +C VD C C C NT S+ C C +GF + ED
Sbjct: 1117 CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCED 1176
Query: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
+ C ++C + HG C+N SF C C G V G +C +D CA D
Sbjct: 1177 VNECMGEEHC--APHG---ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGG 1231
Query: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI----CVNSDDSYTCE--C 592
CV++E SF C C G+ + C D C+ D+G C NS SY C C
Sbjct: 1232 HCVNTEGSFNCLCETGFQPSPESGECVDIDECE--DYGDPVCGTWKCENSPGSYRCVLGC 1289
Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
GF +A +G + T G C N S+ C C +GF ++ G C E
Sbjct: 1290 QPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348
Score = 194 bits (493), Expect = 3e-49
Identities = 126/396 (31%), Positives = 175/396 (44%), Gaps = 21/396 (5%)
Query: 253 CINIPGSYVC-RCKQGYILNS----DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307
C+N PGSY C C++GY S D C +CA C N+ GSF C C
Sbjct: 985 CVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCA------HGKCTNLEGSFRCSCEQ 1038
Query: 308 GYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCA 366
GY + D K C VD CAS C+N +GS+ C C G+ +N D C +D CA
Sbjct: 1039 GYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA 1098
Query: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESY 424
C NT S+SC C G+ +P +C ++ C + C EC N SY
Sbjct: 1099 FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY 1158
Query: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS 483
C C +G+ L NG C V+ C ++H CLN+ SF C C+ GF+ E +C
Sbjct: 1159 QCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217
Query: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHSCV 541
VD C +D CVN + SF C C G + C +D C GD C C
Sbjct: 1218 DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCE 1277
Query: 542 SSEDSFVCQ--CFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599
+S S+ C C G+ + +G + G C N+D S+ C C +GF ++
Sbjct: 1278 NSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEIS 1337
Query: 600 EDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCS 634
G C + C+ C +C N S++C C+
Sbjct: 1338 PSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373
Score = 189 bits (480), Expect = 1e-47
Identities = 121/360 (33%), Positives = 168/360 (46%), Gaps = 23/360 (6%)
Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ-CY 306
CAH C N+ GS+ C C+QGY + SD+ C+ D CA LC+N GSF C C
Sbjct: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079
Query: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYC 365
+GY + EDG C +D CA C N GS+ C+ C G+ +P +C +D C
Sbjct: 1080 NGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDEC 1139
Query: 366 ASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEES 423
C EC NT SY C C +GF L + C +N C + H EC+N S
Sbjct: 1140 EDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGS 1198
Query: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
++C C G+ G +C VD CA D C+NTE SF C C GF + + C
Sbjct: 1199 FFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258
Query: 484 RVDYCLLSDHG---C-EYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSCA----LGD 533
+D C D+G C + C N S+ C C G + +G C +D CA G
Sbjct: 1259 DIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGS 1315
Query: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCEC 592
HG C +++ SF C C +G+ + G C + C+ + C +C N + S+ C C
Sbjct: 1316 HG---FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC 1372
Score = 167 bits (424), Expect = 3e-41
Identities = 141/474 (29%), Positives = 188/474 (39%), Gaps = 75/474 (15%)
Query: 253 CINIPGSYVCR-CKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
C N GS+ C+ C GY + +C D C +C C N GS+ C C G+
Sbjct: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
Query: 311 LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
LA +G C V+ C E H H EC+N+ GS+ C C GF +C +D CA+++
Sbjct: 1168 LA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTD 1226
Query: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA-LNKPGC-EHECVNMEESYYC- 426
CVNT+ S++C C GF +P+ C I+ C P C +C N SY C
Sbjct: 1227 PCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV 1286
Query: 427 -RCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C G+ + PNG C +D CA G C NT+ SF C C +GF I+ C
Sbjct: 1287 LGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345
Query: 485 VDYCLLSDHGCEYS-CVNMDRSFACQCP---------EGHVLRSDGKTCAKLDSCALGDH 534
V+ C L C + C N++ SF C C EGH R G + GDH
Sbjct: 1346 VNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQSMSEAPTGDH 1404
Query: 535 G----------------------------CEHSCV----------------SSEDSFVCQ 550
E C S+E S +C
Sbjct: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
Query: 551 CFEGYILREDGKTCRRK-----DVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
+GYI E T + D C G C + C+N+ Y C C GF K
Sbjct: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524
Query: 604 RCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
+C D C+ CE+ CVN S+ C CS L +RC T DL
Sbjct: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDL 1576
Score = 97.8 bits (242), Expect = 4e-20
Identities = 104/437 (23%), Positives = 167/437 (38%), Gaps = 66/437 (15%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---C-EQLCVNV 297
C+T + C+N GS+ C C+ G+ + + C D C ED+ C C N
Sbjct: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDEC--EDYGDPVCGTWKCENS 1279
Query: 298 PGSFVC--QCYSGYALAEDGKRCVAVDYCASENH-GCEHECVNADGSYLCQCHEGFALNP 354
PGS+ C C G+ +A +G C+ +D CA++ G C N DGS+ C C +GF ++P
Sbjct: 1280 PGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISP 1338
Query: 355 DKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
C ++ C C C N + S+ C C ++ + +C G
Sbjct: 1339 SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL-----EEYDAQEGHCRPRGAGG 1393
Query: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVD-HCAQQDHG-CEQLCLNTEDSFVCQCSE 471
+ +M E+ + +R+D + Q+ H C + C C++
Sbjct: 1394 Q----SMSEA---------PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440
Query: 472 GFLINEDLKTCSRVDYCLLSD---HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
G + C D S+ G Y V +F G + +D C
Sbjct: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTF------GQTMYTDADECV---- 1490
Query: 529 CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDD 586
G C + C+++ +VC C G+ K C D CQ D CE+ CVN++
Sbjct: 1491 -IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--DLACENGECVNTEG 1547
Query: 587 SYTCECLEGFRLAEDGKRCRRK--------------DVC--KSTHHGCEHICVNNGNSYI 630
S+ C C L +RC D+C K T+ C + +Y
Sbjct: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607
Query: 631 -CKCSEGFVLAEDGRRC 646
C C +G ++ C
Sbjct: 1608 ECCCQDGEAWSQQCALC 1624
Score = 70.9 bits (172), Expect = 5e-12
Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYIL 557
+CVN+ + C C G+ L C + C + C++ S+ C C+ GY L
Sbjct: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919
Query: 558 REDGKTCRRKDVCQAIDHG-CE-HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
G T +D+ + G C C N++ SY CEC +G+ + G C+ + C+
Sbjct: 920 ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPG 978
Query: 616 HGCEHICVNNGNSYIC-KCSEGF 637
+ CVN+ SY C C EG+
Sbjct: 979 TCPDGRCVNSPGSYTCLACEEGY 1001
Score = 52.8 bits (125), Expect = 2e-06
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 329 HGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVNTDDSY 383
+GCE+ CV Y C C EGF L+ C ++ C N C H C NT+ SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 384 SCHCLKGFTLNPDKKTC 400
CHC G+ C
Sbjct: 1801 RCHCSPGYVAEAGPPHC 1817
Score = 52.0 bits (123), Expect = 3e-06
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 370 HGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC-ALNKPG--CEH-ECVNMEESY 424
+GC++ CV + Y+C C +GF L+ C +N C LN P C H C N E SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 425 YCRCHRGYTLDPNGKTCS 442
C C GY + C+
Sbjct: 1801 RCHCSPGYVAEAGPPHCT 1818
Score = 48.5 bits (114), Expect = 3e-05
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 11/80 (13%)
Query: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD-------HGCEQLCLNTED 463
GCE+ CV + E Y C C G+ LD C V+ C + HG C NTE
Sbjct: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTEG 1798
Query: 464 SFVCQCSEGFLINEDLKTCS 483
S+ C CS G++ C+
Sbjct: 1799 SYRCHCSPGYVAEAGPPHCT 1818
Score = 47.0 bits (110), Expect = 8e-05
Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 288 HNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG---CEH-ECVNADGSY 342
+ CE CV V + C C+ G+ L CV V+ C N C H C N +GSY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 343 LCQCHEGFALNPDKKTCT 360
C C G+ CT
Sbjct: 1801 RCHCSPGYVAEAGPPHCT 1818
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 575 HGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEH-ICVNNGNSY 629
+GCE+ CV + YTC+C EGF+L C + C + C H C N SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 630 ICKCSEGFVLAEDG 643
C CS G+V AE G
Sbjct: 1801 RCHCSPGYV-AEAG 1813
Score = 44.7 bits (104), Expect = 4e-04
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 534 HGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG---CEH-ICVNSDDSY 588
+GCE+ CV + + C CFEG+ L C + C ++ C H C N++ SY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 589 TCECLEGFRLAEDGKRCRRKD 609
C C G+ C K+
Sbjct: 1801 RCHCSPGYVAEAGPPHCTAKE 1821
Score = 44.3 bits (103), Expect = 5e-04
Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 6/115 (5%)
Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
C+ IN C + ECVN SY C C G LDP+ C D G LC
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS-DKAISMLQG---LCY 675
Query: 460 NTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH 514
+ C I + + CSRV S+ CE + +F CP GH
Sbjct: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFREICPAGH 728
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 452 HGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-------LLSDHGCEYSCVNMD 503
+GCE C+ + + C C EGF ++ C V+ C +L HG C N +
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
Query: 504 RSFACQCPEGHVLRSDGKTC 523
S+ C C G+V + C
Sbjct: 1798 GSYRCHCSPGYVAEAGPPHC 1817
Score = 40.4 bits (93), Expect = 0.008
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 11/84 (13%)
Query: 493 HGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-------ALGDHGCEHSCVSSE 544
+GCE CV + + C C EG L + C ++ C L HG C ++E
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
Query: 545 DSFVCQCFEGYILREDGKTCRRKD 568
S+ C C GY+ C K+
Sbjct: 1798 GSYRCHCSPGYVAEAGPPHCTAKE 1821
Score = 40.0 bits (92), Expect = 0.010
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 11/61 (18%)
Query: 304 QCYSGYAL-----AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKT 358
+C GY +D C+ + C + ECVN GSYLC C G L+P +
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCK------DAECVNTRGSYLCTCRPGLMLDPSRSR 660
Query: 359 C 359
C
Sbjct: 661 C 661
Score = 37.0 bits (84), Expect = 0.086
Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 8/74 (10%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL------CVNVPGSFVCQCY 306
C+ + Y C C +G+ L++ C D+ +D N + C N GS+ C C
Sbjct: 1748 CVRVREGYTCDCFEGFQLDAAHMAC--VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCS 1805
Query: 307 SGYALAEDGKRCVA 320
GY C A
Sbjct: 1806 PGYVAEAGPPHCTA 1819
Score = 35.8 bits (81), Expect = 0.19
Identities = 16/42 (38%), Positives = 20/42 (47%)
Query: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
C I+ C + ECVNT SY C C G L+P + C
Sbjct: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 33.5 bits (75), Expect = 0.95
Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 11/61 (18%)
Query: 591 ECLEGFRL-----AEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRR 645
EC +G++ +D C +CK CVN SY+C C G +L R
Sbjct: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAE------CVNTRGSYLCTCRPGLMLDPSRSR 660
Query: 646 C 646
C
Sbjct: 661 C 661
Score = 32.7 bits (73), Expect = 1.6
Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVA 320
C QGY + T C+ + C + CVN GS++C C G L RCV+
Sbjct: 608 CPQGY-KRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS 663
Score = 32.0 bits (71), Expect = 2.8
Identities = 10/25 (40%), Positives = 17/25 (68%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTC 277
C+N GSY+C C+ G +L+ ++ C
Sbjct: 637 CVNTRGSYLCTCRPGLMLDPSRSRC 661
Score = 31.6 bits (70), Expect = 3.6
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 249 CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQD 281
C H +C N GSY C C GY+ + C ++
Sbjct: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
Score = 31.2 bits (69), Expect = 4.7
Identities = 30/139 (21%), Positives = 52/139 (37%), Gaps = 9/139 (6%)
Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
+CP+G+ R + C ++ C + CV++ S++C C G +L C
Sbjct: 607 ECPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
Query: 569 VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
+ + +C S TC R+ + C R V K+ CE + +
Sbjct: 666 AISML----QGLCYRSLGPGTCTLPLAQRITKQICCCSR--VGKAWGSECEKCPLPGTEA 719
Query: 629 Y--ICKCSEGFVLAEDGRR 645
+ IC G+ A R
Sbjct: 720 FREICPAGHGYTYASSDIR 738
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 207 bits (528), Expect = 3e-53
Identities = 132/390 (33%), Positives = 179/390 (45%), Gaps = 36/390 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 581 CVNSDDSYTC---ECLEGFRLAEDGKRCRR 607
C N + C EC E +R + RC R
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSA-ATRCER 570
Score = 194 bits (493), Expect = 3e-49
Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)
Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 622 CVNNGNSYIC---KCSEGF 637
C N + C +C E +
Sbjct: 542 CFNIQGGFRCLAFECPENY 560
Score = 172 bits (435), Expect = 2e-42
Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)
Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 466 VC---QCSEGF 473
C +C E +
Sbjct: 550 RCLAFECPENY 560
Score = 161 bits (407), Expect = 3e-39
Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
C ++ C H + C G L ++Q C D ++E ++ C
Sbjct: 61 CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
Query: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
C C G A G+ C + V Y C C E + D L + + +
Sbjct: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
Query: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
+++ D C C+ +C +T D C C G+ L D +C +N C
Sbjct: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
C C+N S+ C+ C GY L + +C +D C H C + +C NT S
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
Query: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
F C QC GF I + L C ++ CL C ++C+N + S+ CQ C G
Sbjct: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
Query: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ L +G C +D CA C H CV+S SF C+C GY + C + CQ
Sbjct: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
C H C N+ SY C C GFRL+ DG+ C + C S+ C C N SY
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
Query: 631 CKCSEGFVLAE-DGRRCKKCTE 651
C C G+ L++ DG C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 140 bits (353), Expect = 6e-33
Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)
Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
C+ +C + + C C GY L +G +C V+ C H C + C+NT SF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
C G+ + ED +C +D C H C ++ C N SF C QC G + + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
C ++ C C H+C+++E S+ CQ C GY L E+G C D C
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
C H CVNS S+ CEC G+ + C + C+ + G C H C N SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422
Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
+C CS GF L+ DGR C+ +C+ P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 207 bits (527), Expect = 4e-53
Identities = 133/404 (32%), Positives = 183/404 (45%), Gaps = 38/404 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 581 CVNSDDSYTC---ECLEGFR---LAEDGKRCRRKDVCKSTHHGC 618
C N + C EC E +R + K+ R+ S+ C
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDC 585
Score = 195 bits (496), Expect = 1e-49
Identities = 125/390 (32%), Positives = 173/390 (44%), Gaps = 35/390 (8%)
Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 622 CVNNGNSYIC---KCSEGFVLAEDGRRCKK 648
C N + C +C E + + ++ KK
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATQKSKK 571
Score = 172 bits (435), Expect = 2e-42
Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)
Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 466 VC---QCSEGF 473
C +C E +
Sbjct: 550 RCLAFECPENY 560
Score = 140 bits (353), Expect = 6e-33
Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)
Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
C+ +C + + C C GY L +G +C V+ C H C + C+NT SF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
C G+ + ED +C +D C H C ++ C N SF C QC G + + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
C ++ C C H+C+++E S+ CQ C GY L E+G C D C
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
C H CVNS S+ CEC G+ + C + C+ + G C H C N SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422
Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
+C CS GF L+ DGR C+ +C+ P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 14/124 (11%)
Query: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
D C G C+ C + D VC CF GY L DG +C + C H C C+N+
Sbjct: 178 DRCR-GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 585 DDSYTCE----CLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICK----CS 634
S+ C+ C G+ L ED C+ D C+S H C + IC N S+ C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 635 EGFV 638
GF+
Sbjct: 296 SGFI 299
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 206 bits (524), Expect = 8e-53
Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 581 CVNSDDSYTC---ECLEGFR 597
C N + C EC E +R
Sbjct: 542 CFNIQGGFRCLAFECPENYR 561
Score = 194 bits (493), Expect = 3e-49
Identities = 123/379 (32%), Positives = 168/379 (44%), Gaps = 35/379 (9%)
Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 622 CVNNGNSYIC---KCSEGF 637
C N + C +C E +
Sbjct: 542 CFNIQGGFRCLAFECPENY 560
Score = 172 bits (435), Expect = 2e-42
Identities = 96/251 (38%), Positives = 127/251 (50%), Gaps = 21/251 (8%)
Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 466 VC---QCSEGF 473
C +C E +
Sbjct: 550 RCLAFECPENY 560
Score = 161 bits (407), Expect = 3e-39
Identities = 125/442 (28%), Positives = 181/442 (40%), Gaps = 50/442 (11%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQ--DLCAMEDHNCEQLCVNVPG 299
C ++ C H + C G L ++Q C D ++E ++ C
Sbjct: 61 CRMVQEQCCHSQLE-----ELHCATGISLANEQDRCATPHGDNASLEATFVKRCCH---- 111
Query: 300 SFVCQCYSGYALAEDGKRC---VAVDY-CASENHGC---EHECVNADGSYLCQCHEGFAL 352
C C G A G+ C + V Y C C E + D L + + +
Sbjct: 112 ---C-CLLGRAAQAQGQSCEYSLMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEV 167
Query: 353 NPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPG 412
+++ D C C+ +C +T D C C G+ L D +C +N C
Sbjct: 168 EEEQEDPYLNDRCRGGGP-CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHS 226
Query: 413 CE--HECVNMEESYYCR----CHRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDS 464
C C+N S+ C+ C GY L + +C +D C H C + +C NT S
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDN-SCKDIDECESGIHNCLPDFICQNTLGS 285
Query: 465 FVC----QCSEGFLINEDLKTCSRVDYCLLSDHGCE--YSCVNMDRSFACQ-----CPEG 513
F C QC GF I + L C ++ CL C ++C+N + S+ CQ C G
Sbjct: 286 FRCRPKLQCKSGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRG 344
Query: 514 HVLRSDGKTCAKLDSCALGDHGCE--HSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ L +G C +D CA C H CV+S SF C+C GY + C + CQ
Sbjct: 345 YHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ 404
Query: 572 AIDHG-CEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYI 630
C H C N+ SY C C GFRL+ DG+ C + C S+ C C N SY
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSP--CSQECANVYGSYQ 462
Query: 631 CKCSEGFVLAE-DGRRCKKCTE 651
C C G+ L++ DG C+ E
Sbjct: 463 CYCRRGYQLSDVDGVTCEDIDE 484
Score = 140 bits (353), Expect = 6e-33
Identities = 88/267 (32%), Positives = 124/267 (46%), Gaps = 29/267 (10%)
Query: 413 CEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQ-- 468
C+ +C + + C C GY L +G +C V+ C H C + C+NT SF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 469 --CSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMDRSFAC----QCPEGHVLRSDG 520
C G+ + ED +C +D C H C ++ C N SF C QC G + + G
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG 304
Query: 521 KTCAKLDSCALGDHGCE--HSCVSSEDSFVCQ-----CFEGYILREDGKTCRRKDVCQAI 573
C ++ C C H+C+++E S+ CQ C GY L E+G C D C
Sbjct: 305 N-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 574 DHGCE--HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG--CEHICVNNGNSY 629
C H CVNS S+ CEC G+ + C + C+ + G C H C N SY
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQR-YPGRLCGHKCENTLGSY 422
Query: 630 ICKCSEGFVLAEDGRRCK---KCTEGP 653
+C CS GF L+ DGR C+ +C+ P
Sbjct: 423 LCSCSVGFRLSVDGRSCEDINECSSSP 449
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 206 bits (524), Expect = 8e-53
Identities = 129/380 (33%), Positives = 175/380 (46%), Gaps = 35/380 (9%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVCQ-- 304
C C + VC C GY L SD +C + C H+C + C+N GSF CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 305 --CYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPDK 356
C +GY L ED C +D C S H C + C N GS+ C QC GF +
Sbjct: 246 SSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 357 KTCTKIDYCASSNHGCQ--HECVNTDDSYSC-----HCLKGFTLNPDKKTCRRINYCALN 409
C I+ C S + C H C+NT+ SY+C +C +G+ LN + C ++ CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 410 KPGC--EHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-QDHGCEQLCLNTEDSFV 466
C H CVN S+ C C GY D + C V+ C + C C NT S++
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 467 CQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRS-DGKTCAK 525
C CS GF ++ D ++C ++ C S C C N+ S+ C C G+ L DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINEC--SSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 526 LDSCAL--GDHGCEHSCVSSEDSFVCQC-FEGYILREDGKTCRRKDVCQAIDHGC--EHI 580
+D CAL G H C + C++ SF C C GY L +G+ C+ D C H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 581 CVNSDDSYTC---ECLEGFR 597
C N + C EC E +R
Sbjct: 542 CFNIQGGFRCLAFECPENYR 561
Score = 194 bits (494), Expect = 2e-49
Identities = 130/409 (31%), Positives = 177/409 (43%), Gaps = 44/409 (10%)
Query: 290 CEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQ-- 345
C+Q C + VC C+ GY L DG C V+ C + +H C C+N GS+ CQ
Sbjct: 186 CKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRD 245
Query: 346 --CHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC----HCLKGFTLNPDK 397
C G+ L D +C ID C S H C + C NT S+ C C GF +
Sbjct: 246 SSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGF-IQDAL 303
Query: 398 KTCRRINYCALNKPGCE--HECVNMEESYYCR-----CHRGYTLDPNGKTCSRVDHCAQQ 450
C IN C C H C+N E SY C+ C RGY L+ G C VD CA
Sbjct: 304 GNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPP 363
Query: 451 DHGCEQ--LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-LLSDHGCEYSCVNMDRSFA 507
C + C+N+ SF C+C G+ + + C V+ C C + C N S+
Sbjct: 364 AEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYL 423
Query: 508 CQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILRE-DGKTCRR 566
C C G L DG++C ++ C+ C C + S+ C C GY L + DG TC
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECS--SSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCED 481
Query: 567 KDVC--QAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDVCKSTHHGC--EHI 621
D C H C + C+N S+ C C G+RLA +G+ C+ D C + H C
Sbjct: 482 IDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINET 541
Query: 622 CVNNGNSYIC---KCSEGFVLA--------EDGRRC-KKCTEGPIDLVF 658
C N + C +C E + + D RC K C + VF
Sbjct: 542 CFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVF 590
Score = 173 bits (439), Expect = 6e-43
Identities = 103/285 (36%), Positives = 138/285 (48%), Gaps = 27/285 (9%)
Query: 242 CSTLEHNC--AHFCINIPGSYVCR-----CKQGYILNSDQTTCRIQDLCAMEDHNCEQ-- 292
C ++ C H CIN GSY C+ C +GY LN + T C D CA C +
Sbjct: 312 CLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCAS-ENHGCEHECVNADGSYLCQCHEGFA 351
CVN PGSF C+C +GY + CV V+ C C H+C N GSYLC C GF
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 352 LNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNP-DKKTCRRINYCALNK 410
L+ D ++C I+ C+SS C EC N SY C+C +G+ L+ D TC I+ CAL
Sbjct: 432 LSVDGRSCEDINECSSS--PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPT 489
Query: 411 PG--CEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSF 465
G C + C+N+ S+ C C GY L PNG+ C +D C H C + C N + F
Sbjct: 490 GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGF 549
Query: 466 VC---QCSEGF------LINEDLKTCSRVDYCLLSDHGCEYSCVN 501
C +C E + L E T + C +D C + V+
Sbjct: 550 RCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVH 594
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/124 (33%), Positives = 57/124 (45%), Gaps = 14/124 (11%)
Query: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCE--HICVNS 584
D C G C+ C + D VC CF GY L DG +C + C H C C+N+
Sbjct: 178 DRCR-GGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 585 DDSYTCE----CLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYICK----CS 634
S+ C+ C G+ L ED C+ D C+S H C + IC N S+ C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTEDNS-CKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 635 EGFV 638
GF+
Sbjct: 296 SGFI 299
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 193 bits (491), Expect = 6e-49
Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
CI+ P Y C C G+ L+ T C D C C C N PGSF C C G+
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553
Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
C+ VD C C+ C N GS+LC C G+ P +C +D C S
Sbjct: 554 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 613
Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
C + C N S+ C C GF + ++ ++ CA P C C N S++C C
Sbjct: 614 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 670
Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
G+ G C VD CA+ C C NTE SF C C GF N C VD
Sbjct: 671 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 730
Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
C L+ G E CVN SF C+ CP GH L C +D C+ G C C +
Sbjct: 731 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 786
Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
+E SF C C GY D C D C HG C+N+D S+ C C G
Sbjct: 787 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 841
Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
+R G C D C IC N S+ C C G D C
Sbjct: 842 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 892
Score = 188 bits (478), Expect = 2e-47
Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N+PGS+ C C G+ ++ + D CA E C C N GSF C C +G+
Sbjct: 620 CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 676
Query: 312 AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
G C VD CA C + C N +GS+ C C GF N C +D C +
Sbjct: 677 RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 736
Query: 371 GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
ECVN+ S+ C C G L+ + C ++ C+ P C C N E S+ C
Sbjct: 737 CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 794
Query: 428 CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
C GY P+G+ C+ V+ C + D HG CLNT+ SF C C+ G+ +
Sbjct: 795 CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 850
Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
C VD C D C N D SF C CP GH D +C +D C G C
Sbjct: 851 CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 910
Query: 540 CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
C +S S+ C C GY +G TC D CQ ++G E C N+ SY C
Sbjct: 911 CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 967
Query: 592 CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
C G++ G C+ D C++ G +C N S+ C C +G+ A DGR C
Sbjct: 968 CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1026
Query: 651 E 651
E
Sbjct: 1027 E 1027
Score = 179 bits (455), Expect = 8e-45
Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GS+ C C G+ C+ D CA C C N GSF C C G+
Sbjct: 659 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 718
Query: 312 AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
G C VD C ENH C ECVN+ GS+ C+ C G L+ + CT +D C+S
Sbjct: 719 NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 774
Query: 369 NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
C C NT+ S+ C C G+ + C +N C H EC+N + S+
Sbjct: 775 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 834
Query: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C C GY P G +C VD C+++D +C NT+ SF C C G DL +C
Sbjct: 835 ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 894
Query: 485 VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
VD C L CE N S+ C C G+ +G TC +D C G
Sbjct: 895 VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 949
Query: 536 C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
C C ++ S+ C C GY +D CR + C G +C N S
Sbjct: 950 CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1004
Query: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
+ C C +G+ A DG+ C + C++ C +C N S++C C
Sbjct: 1005 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1051
Score = 127 bits (318), Expect = 6e-29
Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)
Query: 253 CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
C N GS+ C C GY S D C D C C+N GSF C C
Sbjct: 784 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 838
Query: 306 YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
GY G C+ VD C+ E+ C N DGS+ C C G PD +C +D C
Sbjct: 839 APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 898
Query: 366 ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
C N+ SY C C G+ P+ TC ++ C P C N
Sbjct: 899 RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 957
Query: 420 MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
SY C C GY P G C VD C + G +C N SF C C +G+
Sbjct: 958 TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1016
Query: 477 EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
D + C V+ C C + C N++ SF C CP
Sbjct: 1017 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1052
Score = 93.6 bits (231), Expect = 8e-19
Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)
Query: 250 AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
A C N PGSY C C GY D CR + C +C N+PGSF
Sbjct: 952 AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1006
Query: 303 CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
C C GY A DG+ CV V+ C + C C N +GS+LC C + +P C
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066
Query: 361 KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
A + G Q + + C+
Sbjct: 1067 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1126
Query: 396 DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
D R + + C + + GC +C E + Y C RGY L P+G R
Sbjct: 1127 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1185
Query: 444 -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
VD C +D C+ +C+NT + C CS G+ + C D C + CE C
Sbjct: 1186 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1245
Query: 500 VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
VN S+ C C VL + C +S +L D+ C H + + ++
Sbjct: 1246 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1305
Query: 548 V-CQCFEGYILREDGKTCRRKD 568
C C G D C +D
Sbjct: 1306 TECCCLYGEAWGMDCALCPAQD 1327
Score = 77.8 bits (190), Expect = 4e-14
Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
CS + + C N GS+ C C G+ D +C D C Q C N PG
Sbjct: 857 CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 916
Query: 300 SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
S+ C C GY +G C VD C + +G E C N GSY C C G+
Sbjct: 917 SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 973
Query: 352 LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
P C +D C + + G C N S+ C C +G+ D + C +N C +
Sbjct: 974 PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1032
Query: 411 PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
C C N+E S+ C C + DP C A G +
Sbjct: 1033 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1092
Query: 459 ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
L S Q G E D D L + + C + + C
Sbjct: 1093 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1151
Query: 512 EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ + G A+ S L HG + S + S E + R+ + C + VC
Sbjct: 1152 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1204
Query: 572 AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
G C N +T EC++ D C CE CVN S
Sbjct: 1205 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1251
Query: 629 YICKCSEGFVLAEDGRRC 646
Y C C VL RRC
Sbjct: 1252 YHCTCEPPLVLDGSQRRC 1269
Score = 65.9 bits (159), Expect = 2e-10
Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
C+S + C C G+ L G C D C+ + C C NS S+ C C GFR
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 553
Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
C D C C+ C N S++C C G+ A G C+ +CT+ P
Sbjct: 554 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 612
Score = 63.5 bits (153), Expect = 9e-10
Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
C N+PGS+ C C QGY D C + C C LC NV GSF+C C S
Sbjct: 998 CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1057
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
RCV A G + + + GS +C+
Sbjct: 1058 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1117
Query: 348 EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
A PD + T + C + G C+ +C T+ + Y C G
Sbjct: 1118 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1176
Query: 393 LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
+ D R ++ C L + C+ CVN Y C C GY C D CA +
Sbjct: 1177 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1236
Query: 451 DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
+ CE C+NT S+ C C +++ + C + L D+ G + C +
Sbjct: 1237 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1296
Query: 502 --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
+DR C C G D C DS
Sbjct: 1297 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1328
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
C + D CV VP F C+C+ GY L CV ++ C A+ C+N
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529
Query: 339 DGSYLCQCHEGFA 351
DGS+ C C GFA
Sbjct: 1530 DGSFRCICRPGFA 1542
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
GC + CV + E + CRC GY LD C ++ C + + CLNT+ SF
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534
Query: 467 CQCSEGF 473
C C GF
Sbjct: 1535 CICRPGF 1541
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)
Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
+ + C LD C G CV + F C+CF+GY L C D +A
Sbjct: 1466 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1519
Query: 576 GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
C + C+N+D S+ C C GF C
Sbjct: 1520 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 330 GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
GC + CV + C+C +G+ L+ + C I+ C A+S C+NTD S+
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534
Query: 385 CHCLKGF 391
C C GF
Sbjct: 1535 CICRPGF 1541
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)
Query: 239 AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
A C L+ C+ +P + CRC GY L+ + C + C A C
Sbjct: 1467 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1526
Query: 295 VNVPGSFVCQCYSGYALAEDGKRC 318
+N GSF C C G+A C
Sbjct: 1527 LNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)
Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
L + + CR L A H+C QLC V+ P C +G+ C
Sbjct: 238 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 290
Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
VD CA+ C+H EC N G Y C C +GF L+ + +C
Sbjct: 291 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 41.2 bits (95), Expect = 0.005
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
+C +D CA+ CQH EC NT Y+C C GF L+ + +C
Sbjct: 287 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 329
Score = 40.4 bits (93), Expect = 0.008
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
GC + CV + ++C C G+ L+ + C IN C P C + C+N + S+
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1534
Query: 426 CRCHRGY 432
C C G+
Sbjct: 1535 CICRPGF 1541
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)
Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
H C+ + S P+G R +G +C +D CA G C+H C ++ +
Sbjct: 255 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 312
Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
C C +G++L +C + V C FR+ DG
Sbjct: 313 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 349
Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
GC + N IC CS V GR C+ C
Sbjct: 350 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 380
Score = 38.1 bits (87), Expect = 0.039
Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)
Query: 570 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
C +D CV + +TC C +G+RL C + C C + C+N
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529
Query: 626 GNSYICKCSEGFVLAEDGRRC 646
S+ C C GF C
Sbjct: 1530 DGSFRCICRPGFAPTHQPHHC 1550
Score = 37.4 bits (85), Expect = 0.066
Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)
Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
+C VD CA C NT + C C +GFL++ +C + ++S+ + C
Sbjct: 287 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 342
Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
+ R C P +LR+ K C A G GC+ + F +C GY
Sbjct: 343 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 398
Score = 36.2 bits (82), Expect = 0.15
Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)
Query: 445 DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
+ C D C+ + F C+C +G+ ++ C ++ C S C+
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1527
Query: 501 NMDRSFACQCPEGHVLRSDGKTCA 524
N D SF C C G CA
Sbjct: 1528 NTDGSFRCICRPGFAPTHQPHHCA 1551
Score = 34.7 bits (78), Expect = 0.43
Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)
Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
+C ++ CA C+H EC N Y C C G+ LD + +C ++
Sbjct: 287 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 345
Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
+D GC L +C CS
Sbjct: 346 LRDGGCSLPILRNITKQICCCS 367
Score = 34.3 bits (77), Expect = 0.56
Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)
Query: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
C + D CV + F C+C +G+ L C ++ C + C ++ C+++
Sbjct: 1470 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1529
Query: 544 EDSFVCQCFEGY 555
+ SF C C G+
Sbjct: 1530 DGSFRCICRPGF 1541
Score = 32.3 bits (72), Expect = 2.1
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
C H C N G Y C C G++L+S +++C Q + + C
Sbjct: 300 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 342
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 193 bits (491), Expect = 6e-49
Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
CI+ P Y C C G+ L+ T C D C C C N PGSF C C G+
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583
Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
C+ VD C C+ C N GS+LC C G+ P +C +D C S
Sbjct: 584 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 643
Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
C + C N S+ C C GF + ++ ++ CA P C C N S++C C
Sbjct: 644 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 700
Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
G+ G C VD CA+ C C NTE SF C C GF N C VD
Sbjct: 701 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 760
Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
C L+ G E CVN SF C+ CP GH L C +D C+ G C C +
Sbjct: 761 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 816
Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
+E SF C C GY D C D C HG C+N+D S+ C C G
Sbjct: 817 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 871
Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
+R G C D C IC N S+ C C G D C
Sbjct: 872 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 922
Score = 188 bits (478), Expect = 2e-47
Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N+PGS+ C C G+ ++ + D CA E C C N GSF C C +G+
Sbjct: 650 CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 706
Query: 312 AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
G C VD CA C + C N +GS+ C C GF N C +D C +
Sbjct: 707 RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 766
Query: 371 GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
ECVN+ S+ C C G L+ + C ++ C+ P C C N E S+ C
Sbjct: 767 CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 824
Query: 428 CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
C GY P+G+ C+ V+ C + D HG CLNT+ SF C C+ G+ +
Sbjct: 825 CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 880
Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
C VD C D C N D SF C CP GH D +C +D C G C
Sbjct: 881 CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 940
Query: 540 CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
C +S S+ C C GY +G TC D CQ ++G E C N+ SY C
Sbjct: 941 CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 997
Query: 592 CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
C G++ G C+ D C++ G +C N S+ C C +G+ A DGR C
Sbjct: 998 CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1056
Query: 651 E 651
E
Sbjct: 1057 E 1057
Score = 179 bits (455), Expect = 8e-45
Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GS+ C C G+ C+ D CA C C N GSF C C G+
Sbjct: 689 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 748
Query: 312 AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
G C VD C ENH C ECVN+ GS+ C+ C G L+ + CT +D C+S
Sbjct: 749 NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 804
Query: 369 NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
C C NT+ S+ C C G+ + C +N C H EC+N + S+
Sbjct: 805 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 864
Query: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C C GY P G +C VD C+++D +C NT+ SF C C G DL +C
Sbjct: 865 ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 924
Query: 485 VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
VD C L CE N S+ C C G+ +G TC +D C G
Sbjct: 925 VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 979
Query: 536 C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
C C ++ S+ C C GY +D CR + C G +C N S
Sbjct: 980 CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1034
Query: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
+ C C +G+ A DG+ C + C++ C +C N S++C C
Sbjct: 1035 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1081
Score = 127 bits (318), Expect = 6e-29
Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)
Query: 253 CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
C N GS+ C C GY S D C D C C+N GSF C C
Sbjct: 814 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 868
Query: 306 YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
GY G C+ VD C+ E+ C N DGS+ C C G PD +C +D C
Sbjct: 869 APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 928
Query: 366 ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
C N+ SY C C G+ P+ TC ++ C P C N
Sbjct: 929 RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 987
Query: 420 MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
SY C C GY P G C VD C + G +C N SF C C +G+
Sbjct: 988 TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1046
Query: 477 EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
D + C V+ C C + C N++ SF C CP
Sbjct: 1047 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1082
Score = 93.6 bits (231), Expect = 8e-19
Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)
Query: 250 AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
A C N PGSY C C GY D CR + C +C N+PGSF
Sbjct: 982 AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1036
Query: 303 CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
C C GY A DG+ CV V+ C + C C N +GS+LC C + +P C
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096
Query: 361 KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
A + G Q + + C+
Sbjct: 1097 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1156
Query: 396 DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
D R + + C + + GC +C E + Y C RGY L P+G R
Sbjct: 1157 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1215
Query: 444 -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
VD C +D C+ +C+NT + C CS G+ + C D C + CE C
Sbjct: 1216 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1275
Query: 500 VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
VN S+ C C VL + C +S +L D+ C H + + ++
Sbjct: 1276 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1335
Query: 548 V-CQCFEGYILREDGKTCRRKD 568
C C G D C +D
Sbjct: 1336 TECCCLYGEAWGMDCALCPAQD 1357
Score = 77.8 bits (190), Expect = 4e-14
Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
CS + + C N GS+ C C G+ D +C D C Q C N PG
Sbjct: 887 CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 946
Query: 300 SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
S+ C C GY +G C VD C + +G E C N GSY C C G+
Sbjct: 947 SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1003
Query: 352 LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
P C +D C + + G C N S+ C C +G+ D + C +N C +
Sbjct: 1004 PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1062
Query: 411 PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
C C N+E S+ C C + DP C A G +
Sbjct: 1063 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1122
Query: 459 ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
L S Q G E D D L + + C + + C
Sbjct: 1123 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1181
Query: 512 EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ + G A+ S L HG + S + S E + R+ + C + VC
Sbjct: 1182 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1234
Query: 572 AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
G C N +T EC++ D C CE CVN S
Sbjct: 1235 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1281
Query: 629 YICKCSEGFVLAEDGRRC 646
Y C C VL RRC
Sbjct: 1282 YHCTCEPPLVLDGSQRRC 1299
Score = 65.9 bits (159), Expect = 2e-10
Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
C+S + C C G+ L G C D C+ + C C NS S+ C C GFR
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 583
Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
C D C C+ C N S++C C G+ A G C+ +CT+ P
Sbjct: 584 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 642
Score = 63.5 bits (153), Expect = 9e-10
Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
C N+PGS+ C C QGY D C + C C LC NV GSF+C C S
Sbjct: 1028 CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1087
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
RCV A G + + + GS +C+
Sbjct: 1088 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1147
Query: 348 EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
A PD + T + C + G C+ +C T+ + Y C G
Sbjct: 1148 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1206
Query: 393 LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
+ D R ++ C L + C+ CVN Y C C GY C D CA +
Sbjct: 1207 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1266
Query: 451 DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
+ CE C+NT S+ C C +++ + C + L D+ G + C +
Sbjct: 1267 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1326
Query: 502 --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
+DR C C G D C DS
Sbjct: 1327 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1358
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
C + D CV VP F C+C+ GY L CV ++ C A+ C+N
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559
Query: 339 DGSYLCQCHEGFA 351
DGS+ C C GFA
Sbjct: 1560 DGSFRCICRPGFA 1572
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
GC + CV + E + CRC GY LD C ++ C + + CLNT+ SF
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564
Query: 467 CQCSEGF 473
C C GF
Sbjct: 1565 CICRPGF 1571
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)
Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
+ + C LD C G CV + F C+CF+GY L C D +A
Sbjct: 1496 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1549
Query: 576 GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
C + C+N+D S+ C C GF C
Sbjct: 1550 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 330 GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
GC + CV + C+C +G+ L+ + C I+ C A+S C+NTD S+
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564
Query: 385 CHCLKGF 391
C C GF
Sbjct: 1565 CICRPGF 1571
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)
Query: 239 AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
A C L+ C+ +P + CRC GY L+ + C + C A C
Sbjct: 1497 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1556
Query: 295 VNVPGSFVCQCYSGYALAEDGKRC 318
+N GSF C C G+A C
Sbjct: 1557 LNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)
Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
L + + CR L A H+C QLC V+ P C +G+ C
Sbjct: 268 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 320
Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
VD CA+ C+H EC N G Y C C +GF L+ + +C
Sbjct: 321 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 41.2 bits (95), Expect = 0.005
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
+C +D CA+ CQH EC NT Y+C C GF L+ + +C
Sbjct: 317 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 359
Score = 40.4 bits (93), Expect = 0.008
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
GC + CV + ++C C G+ L+ + C IN C P C + C+N + S+
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1564
Query: 426 CRCHRGY 432
C C G+
Sbjct: 1565 CICRPGF 1571
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)
Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
H C+ + S P+G R +G +C +D CA G C+H C ++ +
Sbjct: 285 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 342
Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
C C +G++L +C + V C FR+ DG
Sbjct: 343 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 379
Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
GC + N IC CS V GR C+ C
Sbjct: 380 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 410
Score = 38.1 bits (87), Expect = 0.039
Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)
Query: 570 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
C +D CV + +TC C +G+RL C + C C + C+N
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559
Query: 626 GNSYICKCSEGFVLAEDGRRC 646
S+ C C GF C
Sbjct: 1560 DGSFRCICRPGFAPTHQPHHC 1580
Score = 37.4 bits (85), Expect = 0.066
Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)
Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
+C VD CA C NT + C C +GFL++ +C + ++S+ + C
Sbjct: 317 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 372
Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
+ R C P +LR+ K C A G GC+ + F +C GY
Sbjct: 373 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 428
Score = 36.2 bits (82), Expect = 0.15
Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)
Query: 445 DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
+ C D C+ + F C+C +G+ ++ C ++ C S C+
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1557
Query: 501 NMDRSFACQCPEGHVLRSDGKTCA 524
N D SF C C G CA
Sbjct: 1558 NTDGSFRCICRPGFAPTHQPHHCA 1581
Score = 34.7 bits (78), Expect = 0.43
Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)
Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
+C ++ CA C+H EC N Y C C G+ LD + +C ++
Sbjct: 317 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 375
Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
+D GC L +C CS
Sbjct: 376 LRDGGCSLPILRNITKQICCCS 397
Score = 34.3 bits (77), Expect = 0.56
Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)
Query: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
C + D CV + F C+C +G+ L C ++ C + C ++ C+++
Sbjct: 1500 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1559
Query: 544 EDSFVCQCFEGY 555
+ SF C C G+
Sbjct: 1560 DGSFRCICRPGF 1571
Score = 32.3 bits (72), Expect = 2.1
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
C H C N G Y C C G++L+S +++C Q + + C
Sbjct: 330 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 372
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 193 bits (491), Expect = 6e-49
Identities = 134/411 (32%), Positives = 166/411 (40%), Gaps = 29/411 (7%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
CI+ P Y C C G+ L+ T C D C C C N PGSF C C G+
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620
Query: 312 AEDGKRCVAVDYCASENHGCE-HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
C+ VD C C+ C N GS+LC C G+ P +C +D C S
Sbjct: 621 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPG 680
Query: 371 GC-QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESYYCRC 428
C + C N S+ C C GF + ++ ++ CA P C C N S++C C
Sbjct: 681 LCGRGACKNLPGSFRCVCPAGFRGSACEED---VDECAQEPPPCGPGRCDNTAGSFHCAC 737
Query: 429 HRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
G+ G C VD CA+ C C NTE SF C C GF N C VD
Sbjct: 738 PAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDE 797
Query: 488 CL--LSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVS 542
C L+ G E CVN SF C+ CP GH L C +D C+ G C C +
Sbjct: 798 CENHLACPGQE--CVNSPGSFQCRTCPSGHHLHRG--RCTDVDECSSGAPPCGPHGHCTN 853
Query: 543 SEDSFVCQCFEGYILRE-------DGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEG 595
+E SF C C GY D C D C HG C+N+D S+ C C G
Sbjct: 854 TEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFC--FPHG---ECLNTDGSFACTCAPG 908
Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
+R G C D C IC N S+ C C G D C
Sbjct: 909 YRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASC 959
Score = 188 bits (478), Expect = 2e-47
Identities = 138/421 (32%), Positives = 185/421 (43%), Gaps = 35/421 (8%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N+PGS+ C C G+ ++ + D CA E C C N GSF C C +G+
Sbjct: 687 CKNLPGSFRCVCPAGFRGSACEEDV---DECAQEPPPCGPGRCDNTAGSFHCACPAGFRS 743
Query: 312 AEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
G C VD CA C + C N +GS+ C C GF N C +D C +
Sbjct: 744 RGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLA 803
Query: 371 GCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC--EHECVNMEESYYCR 427
ECVN+ S+ C C G L+ + C ++ C+ P C C N E S+ C
Sbjct: 804 CPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCS 861
Query: 428 CHRGYTLDPNGKT--CSRVDHCAQQD----HGCEQLCLNTEDSFVCQCSEGFLINEDLKT 481
C GY P+G+ C+ V+ C + D HG CLNT+ SF C C+ G+ +
Sbjct: 862 CAPGYRA-PSGRPGPCADVNECLEGDFCFPHG---ECLNTDGSFACTCAPGYRPGPRGAS 917
Query: 482 CSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHS 539
C VD C D C N D SF C CP GH D +C +D C G C
Sbjct: 918 CLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQR 977
Query: 540 CVSSEDSFVC--QCFEGYILREDGKTCRRKDVCQAIDHGCE----HICVNSDDSYTCE-- 591
C +S S+ C C GY +G TC D CQ ++G E C N+ SY C
Sbjct: 978 CENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQ--EYGPEICGAQRCENTPGSYRCTPA 1034
Query: 592 CLEGFRLAEDGKRCRRKDVCKSTHH-GCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCT 650
C G++ G C+ D C++ G +C N S+ C C +G+ A DGR C
Sbjct: 1035 CDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVN 1093
Query: 651 E 651
E
Sbjct: 1094 E 1094
Score = 179 bits (455), Expect = 8e-45
Identities = 128/407 (31%), Positives = 174/407 (42%), Gaps = 40/407 (9%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPGSFVCQCYSGYAL 311
C N GS+ C C G+ C+ D CA C C N GSF C C G+
Sbjct: 726 CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQP 785
Query: 312 AEDGKRCVAVDYCASENH-GCE-HECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCASS 368
G C VD C ENH C ECVN+ GS+ C+ C G L+ + CT +D C+S
Sbjct: 786 NTAGSECEDVDEC--ENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSG 841
Query: 369 NHGC--QHECVNTDDSYSCHCLKGFTLNPDKK-TCRRINYCALNKPGCEH-ECVNMEESY 424
C C NT+ S+ C C G+ + C +N C H EC+N + S+
Sbjct: 842 APPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSF 901
Query: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
C C GY P G +C VD C+++D +C NT+ SF C C G DL +C
Sbjct: 902 ACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLD 961
Query: 485 VDYC------LLSDHGCEYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSC-ALGDHG 535
VD C L CE N S+ C C G+ +G TC +D C G
Sbjct: 962 VDECRERGPALCGSQRCE----NSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEI 1016
Query: 536 C-EHSCVSSEDSFVC--QCFEGYILR-----EDGKTCRRKDVCQAIDHGCEHICVNSDDS 587
C C ++ S+ C C GY +D CR + C G +C N S
Sbjct: 1017 CGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFC-----GAHAVCQNLPGS 1071
Query: 588 YTCECLEGFRLAEDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKC 633
+ C C +G+ A DG+ C + C++ C +C N S++C C
Sbjct: 1072 FQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVC 1118
Score = 127 bits (318), Expect = 6e-29
Identities = 87/276 (31%), Positives = 109/276 (39%), Gaps = 24/276 (8%)
Query: 253 CINIPGSYVCRCKQGYILNS-------DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQC 305
C N GS+ C C GY S D C D C C+N GSF C C
Sbjct: 851 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGE-----CLNTDGSFACTC 905
Query: 306 YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYC 365
GY G C+ VD C+ E+ C N DGS+ C C G PD +C +D C
Sbjct: 906 APGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDEC 965
Query: 366 ASSNHGC--QHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGC--EHECVN 419
C N+ SY C C G+ P+ TC ++ C P C N
Sbjct: 966 RERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEG-TCDDVDECQEYGPEICGAQRCEN 1024
Query: 420 MEESYYCR--CHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLIN 476
SY C C GY P G C VD C + G +C N SF C C +G+
Sbjct: 1025 TPGSYRCTPACDPGYQPTPGGG-CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGA 1083
Query: 477 EDLKTCSRVDYCLLSDHGCEYS-CVNMDRSFACQCP 511
D + C V+ C C + C N++ SF C CP
Sbjct: 1084 RDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCP 1119
Score = 93.6 bits (231), Expect = 8e-19
Identities = 99/382 (25%), Positives = 138/382 (36%), Gaps = 69/382 (18%)
Query: 250 AHFCINIPGSYVCR--CKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFV 302
A C N PGSY C C GY D CR + C +C N+PGSF
Sbjct: 1019 AQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCG-----AHAVCQNLPGSFQ 1073
Query: 303 CQCYSGYALAEDGKRCVAVDYCASENHGCEHE-CVNADGSYLCQC-HEGFALNPDKKTCT 360
C C GY A DG+ CV V+ C + C C N +GS+LC C + +P C
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133
Query: 361 KIDYCASSNHGCQHECVNT-------------------------DDSYSCHCLKGFTLNP 395
A + G Q + + C+
Sbjct: 1134 PPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDAC 1193
Query: 396 DKKTCRRINY----CALNK---PGCE-HECVNMEESYY---CRCHRGYTLDPNGKTCSR- 443
D R + + C + + GC +C E + Y C RGY L P+G R
Sbjct: 1194 DNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGY-LAPSGDLSLRR 1252
Query: 444 -VDHCAQ-QDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYS-C 499
VD C +D C+ +C+NT + C CS G+ + C D C + CE C
Sbjct: 1253 DVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRC 1312
Query: 500 VNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH------------GCEHSCVSSEDSF 547
VN S+ C C VL + C +S +L D+ C H + + ++
Sbjct: 1313 VNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATY 1372
Query: 548 V-CQCFEGYILREDGKTCRRKD 568
C C G D C +D
Sbjct: 1373 TECCCLYGEAWGMDCALCPAQD 1394
Score = 77.8 bits (190), Expect = 4e-14
Identities = 110/438 (25%), Positives = 149/438 (34%), Gaps = 58/438 (13%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPG 299
CS + + C N GS+ C C G+ D +C D C Q C N PG
Sbjct: 924 CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 983
Query: 300 SFVC--QCYSGYALAEDGKRCVAVDYCASENHGCE----HECVNADGSYLC--QCHEGFA 351
S+ C C GY +G C VD C + +G E C N GSY C C G+
Sbjct: 984 SYRCVRDCDPGYHAGPEG-TCDDVDEC--QEYGPEICGAQRCENTPGSYRCTPACDPGYQ 1040
Query: 352 LNPDKKTCTKIDYCASSNH-GCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNK 410
P C +D C + + G C N S+ C C +G+ D + C +N C +
Sbjct: 1041 PTPG-GGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1099
Query: 411 PGCEHE-CVNMEESYYCRC-HRGYTLDPNGKTCSRVDHCAQQDHGCEQLC---------- 458
C C N+E S+ C C + DP C A G +
Sbjct: 1100 GVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARP 1159
Query: 459 ----LNTEDSFVCQCSEGFLINE---DLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCP 511
L S Q G E D D L + + C + + C
Sbjct: 1160 PPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGC- 1218
Query: 512 EGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQ 571
+ + G A+ S L HG + S + S E + R+ + C + VC
Sbjct: 1219 --RIQQCPGTETAEYQS--LCPHGRGYLAPSGDLSLRRDVDECQLFRD--QVC-KSGVCV 1271
Query: 572 AIDHGCEHICVNSDDSYT--CECLEGFRLAEDGKRCRRKDVCKSTHHGCE-HICVNNGNS 628
G C N +T EC++ D C CE CVN S
Sbjct: 1272 NTAPGYSCYCSNGYYYHTQRLECID-------------NDECADEEPACEGGRCVNTVGS 1318
Query: 629 YICKCSEGFVLAEDGRRC 646
Y C C VL RRC
Sbjct: 1319 YHCTCEPPLVLDGSQRRC 1336
Score = 65.9 bits (159), Expect = 2e-10
Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 540 CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRL 598
C+S + C C G+ L G C D C+ + C C NS S+ C C GFR
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRA 620
Query: 599 AEDGKRCRRKDVCKSTHHGCE-HICVNNGNSYICKCSEGFVLAEDGRRCK---KCTEGP 653
C D C C+ C N S++C C G+ A G C+ +CT+ P
Sbjct: 621 GPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSP 679
Score = 63.5 bits (153), Expect = 9e-10
Identities = 83/332 (25%), Positives = 117/332 (35%), Gaps = 57/332 (17%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQC-YSGYA 310
C N+PGS+ C C QGY D C + C C LC NV GSF+C C S
Sbjct: 1065 CQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEE 1124
Query: 311 LAEDGKRCVAVDYCASENHGCEHECVNAD-----------------------GSYLCQCH 347
RCV A G + + + GS +C+
Sbjct: 1125 FDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECY 1184
Query: 348 EGFALNPDK------KTCTKIDYCASSNHG----CQ-HECVNTDDS-YSCHCLKG---FT 392
A PD + T + C + G C+ +C T+ + Y C G
Sbjct: 1185 FDTAA-PDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLA 1243
Query: 393 LNPDKKTCRRINYCALNKPG-CEHE-CVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQ 450
+ D R ++ C L + C+ CVN Y C C GY C D CA +
Sbjct: 1244 PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADE 1303
Query: 451 DHGCE-QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDH--------GCEYSCVN 501
+ CE C+NT S+ C C +++ + C + L D+ G + C +
Sbjct: 1304 EPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSH 1363
Query: 502 --MDRSFA---CQCPEGHVLRSDGKTCAKLDS 528
+DR C C G D C DS
Sbjct: 1364 PRLDRQATYTECCCLYGEAWGMDCALCPAQDS 1395
Score = 52.4 bits (124), Expect = 2e-06
Identities = 26/73 (35%), Positives = 34/73 (46%), Gaps = 4/73 (5%)
Query: 283 CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYC----ASENHGCEHECVNA 338
C + D CV VP F C+C+ GY L CV ++ C A+ C+N
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596
Query: 339 DGSYLCQCHEGFA 351
DGS+ C C GFA
Sbjct: 1597 DGSFRCICRPGFA 1609
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHG----CEQLCLNTEDSFV 466
GC + CV + E + CRC GY LD C ++ C + + CLNT+ SF
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601
Query: 467 CQCSEGF 473
C C GF
Sbjct: 1602 CICRPGF 1608
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 10/91 (10%)
Query: 519 DGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTC---RRKDVCQAIDH 575
+ + C LD C G CV + F C+CF+GY L C D +A
Sbjct: 1533 EAEECGILDGCTNG------RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASP 1586
Query: 576 GCEHI-CVNSDDSYTCECLEGFRLAEDGKRC 605
C + C+N+D S+ C C GF C
Sbjct: 1587 LCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 5/67 (7%)
Query: 330 GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYC----ASSNHGCQHECVNTDDSYS 384
GC + CV + C+C +G+ L+ + C I+ C A+S C+NTD S+
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601
Query: 385 CHCLKGF 391
C C GF
Sbjct: 1602 CICRPGF 1608
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 33/84 (39%), Gaps = 4/84 (4%)
Query: 239 AHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLC----AMEDHNCEQLC 294
A C L+ C+ +P + CRC GY L+ + C + C A C
Sbjct: 1534 AEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARC 1593
Query: 295 VNVPGSFVCQCYSGYALAEDGKRC 318
+N GSF C C G+A C
Sbjct: 1594 LNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/100 (32%), Positives = 44/100 (44%), Gaps = 18/100 (18%)
Query: 270 LNSDQTTCRIQDLCAMEDHNCEQLC---------VNVPGSFVCQCYSGYALAEDGKRCVA 320
L + + CR L A H+C QLC V+ P C +G+ C
Sbjct: 305 LRTQEVCCRGAGL-AWGVHDC-QLCSERLGNSERVSAPDG---PCPTGFERVNGS--CED 357
Query: 321 VDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTC 359
VD CA+ C+H EC N G Y C C +GF L+ + +C
Sbjct: 358 VDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 41.2 bits (95), Expect = 0.005
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 358 TCTKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTC 400
+C +D CA+ CQH EC NT Y+C C GF L+ + +C
Sbjct: 354 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSC 396
Score = 40.4 bits (93), Expect = 0.008
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 371 GCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC---ALNKPGCEH-ECVNMEESYY 425
GC + CV + ++C C G+ L+ + C IN C P C + C+N + S+
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFR 1601
Query: 426 CRCHRGY 432
C C G+
Sbjct: 1602 CICRPGF 1608
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/162 (23%), Positives = 56/162 (34%), Gaps = 41/162 (25%)
Query: 493 HGCEYSCVNMDRSFACQCPEGHVL----RSDGKTCAKLDSCALGDHGCEH-SCVSSEDSF 547
H C+ + S P+G R +G +C +D CA G C+H C ++ +
Sbjct: 322 HDCQLCSERLGNSERVSAPDGPCPTGFERVNG-SCEDVDECATGGR-CQHGECANTRGGY 379
Query: 548 VCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
C C +G++L +C + V C FR+ DG
Sbjct: 380 TCVCPDGFLLDSSRSSCISQHVISEAKGPC------------------FRVLRDG----- 416
Query: 608 KDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC 649
GC + N IC CS V GR C+ C
Sbjct: 417 ---------GCSLPILRNITKQICCCSR--VGKAWGRGCQLC 447
Score = 38.1 bits (87), Expect = 0.039
Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 4/81 (4%)
Query: 570 CQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEHI-CVNN 625
C +D CV + +TC C +G+RL C + C C + C+N
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596
Query: 626 GNSYICKCSEGFVLAEDGRRC 646
S+ C C GF C
Sbjct: 1597 DGSFRCICRPGFAPTHQPHHC 1617
Score = 37.4 bits (85), Expect = 0.066
Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 12/120 (10%)
Query: 440 TCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSC 499
+C VD CA C NT + C C +GFL++ +C + ++S+ + C
Sbjct: 354 SCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSC--ISQHVISE--AKGPC 409
Query: 500 VNMDRSFACQCPEGHVLRSDGK--TCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGY 555
+ R C P +LR+ K C A G GC+ + F +C GY
Sbjct: 410 FRVLRDGGCSLP---ILRNITKQICCCSRVGKAWG-RGCQLCPPFGSEGFREICPAGPGY 465
Score = 36.2 bits (82), Expect = 0.15
Identities = 20/84 (23%), Positives = 31/84 (36%), Gaps = 4/84 (4%)
Query: 445 DHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC----LLSDHGCEYSCV 500
+ C D C+ + F C+C +G+ ++ C ++ C S C+
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCL 1594
Query: 501 NMDRSFACQCPEGHVLRSDGKTCA 524
N D SF C C G CA
Sbjct: 1595 NTDGSFRCICRPGFAPTHQPHHCA 1618
Score = 34.7 bits (78), Expect = 0.43
Identities = 22/82 (26%), Positives = 33/82 (40%), Gaps = 11/82 (13%)
Query: 399 TCRRINYCALNKPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQ-------- 449
+C ++ CA C+H EC N Y C C G+ LD + +C ++
Sbjct: 354 SCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRV 412
Query: 450 -QDHGCEQLCLNTEDSFVCQCS 470
+D GC L +C CS
Sbjct: 413 LRDGGCSLPILRNITKQICCCS 434
Score = 34.3 bits (77), Expect = 0.56
Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 4/72 (5%)
Query: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG---CEHS-CVSS 543
C + D CV + F C+C +G+ L C ++ C + C ++ C+++
Sbjct: 1537 CGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNT 1596
Query: 544 EDSFVCQCFEGY 555
+ SF C C G+
Sbjct: 1597 DGSFRCICRPGF 1608
Score = 32.3 bits (72), Expect = 2.1
Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC 290
C H C N G Y C C G++L+S +++C Q + + C
Sbjct: 367 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPC 409
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 187 bits (476), Expect = 3e-47
Identities = 127/415 (30%), Positives = 173/415 (41%), Gaps = 53/415 (12%)
Query: 263 RCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVD 322
+C G+ L+S C +D CA + C C N G++ C C G +A DG+ C +D
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAA-GNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149
Query: 323 YCASENHGCE--HECVNADGSYLC--QCHEGFALNPDKKTCTKIDYCASSNHGCQHECVN 378
CA H C +C N GSY C +C GF D +C I+ C S+ C C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQRCFN 5208
Query: 379 TDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYC--RCHRGYTLDP 436
S+ C C G+ L K C +N C N + C N Y C C G T
Sbjct: 5209 AIGSFHCGCEPGYQLKGRK--CMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266
Query: 437 NGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHG 494
NG TC +D C H C Q+C NT S+ C C G+ + C ++ C
Sbjct: 5267 NG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKP 5325
Query: 495 CEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVS------------ 542
C + C N SF C CP G L DGK+CA L+ L ++G ++S +
Sbjct: 5326 CAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQ 5383
Query: 543 -----SEDSFVCQCFEGY---------ILREDGKTC-----RRKDVCQAIDH-----GCE 578
+ S + + Y R KTC D C ID C+
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQ 5443
Query: 579 HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVC--KSTHHGCEHICVNNGNSYIC 631
H C N+ SY C C G++L +GK C+ D C ++ H G +C N SY C
Sbjct: 5444 HECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQC 5498
Score = 182 bits (462), Expect = 1e-45
Identities = 128/415 (30%), Positives = 174/415 (41%), Gaps = 65/415 (15%)
Query: 304 QCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKID 363
QC SG+ L G C D CA+ N C H C NA G+Y C C +G + D +TC ID
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149
Query: 364 YCASSNHGCQ--HECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVN 419
CA H C +C NT SY C C GF D +C+ IN C + P C C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSP-CHQRCFN 5208
Query: 420 MEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVC--QCSEGFLINE 477
S++C C GY L G+ C V+ C Q +Q C NT + C C G E
Sbjct: 5209 AIGSFHCGCEPGYQL--KGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAE 5266
Query: 478 DLKTCSRVDYCLLSDHGCEYS--CVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHG 535
+ TC +D C H C Y+ C N S+ C CP G+ + G+ C ++ C
Sbjct: 5267 N-GTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKP 5325
Query: 536 CEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSD---------- 585
C H C ++ SF C C G L DGK+C + + ++G ++ N
Sbjct: 5326 CAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQ 5383
Query: 586 ------------DSYT-----------------CECLEGFRLAEDGKRCRRKDVCKSTHH 616
SY+ C EG + D C D C++T
Sbjct: 5384 PQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDECENT-D 5440
Query: 617 GCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KCTE-----GPIDLVFVIDGS 663
C+H C N SY C C G+ L +G+ C+ +C E GP + F + GS
Sbjct: 5441 ACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGS 5495
Score = 179 bits (453), Expect = 1e-44
Identities = 120/391 (30%), Positives = 163/391 (41%), Gaps = 58/391 (14%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCE--QLCVNVPGSFVC--Q 304
C+H C N G+Y C C +G + +D TC+ D CA+ H C Q C N GS+ C +
Sbjct: 5117 CSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVR 5176
Query: 305 CYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDY 364
C SG+ DG C ++ C E+ C C NA GS+ C C G+ L K C ++
Sbjct: 5177 CGSGFRRTSDGLSCQDINEC-QESSPCHQRCFNAIGSFHCGCEPGYQLKGRK--CMDVNE 5233
Query: 365 CASSNHGCQHECVNTDDSYSC--HCLKGFTLNPDKKTCRRINYCALNKPGCEHE--CVNM 420
C + C NT Y C C G T + TC I+ C C + C N
Sbjct: 5234 CRQNVCRPDQHCKNTRGGYKCIDLCPNGMT-KAENGTCIDIDECKDGTHQCRYNQICENT 5292
Query: 421 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 480
SY C C RGY G+ C ++ C Q C C NT SF C C G + D K
Sbjct: 5293 RGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGK 5352
Query: 481 TCSRVDYCLLSDHGCEYSCVNM-------------------------------------- 502
+C+ ++ L ++G +YS N+
Sbjct: 5353 SCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSR 5410
Query: 503 -DRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDG 561
R+ CPEG D TC +D C D C+H C ++ S+ C C GY L +G
Sbjct: 5411 TRRTIRKTCPEGSEASHD--TCVDIDECENTD-ACQHECKNTFGSYQCICPPGYQLTHNG 5467
Query: 562 KTCRRKDVC--QAIDHGCEHICVNSDDSYTC 590
KTC+ D C Q + G +C N SY C
Sbjct: 5468 KTCQDIDECLEQNVHCGPNRMCFNMRGSYQC 5498
Score = 144 bits (363), Expect = 4e-34
Identities = 91/281 (32%), Positives = 125/281 (44%), Gaps = 14/281 (4%)
Query: 374 HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
H ++ D S C GFTL+ C + CA P C H C N +YYC C +G T
Sbjct: 5080 HASISKGDR-SNQCPSGFTLDSVGPFCADEDECAAGNP-CSHSCHNAMGTYYCSCPKGLT 5137
Query: 434 LDPNGKTCSRVDHCAQQDHGCE--QLCLNTEDSFVC--QCSEGFLINEDLKTCSRVDYCL 489
+ +G+TC +D CA H C Q C NT S+ C +C GF D +C ++ C
Sbjct: 5138 IAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQ 5197
Query: 490 LSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVC 549
S C C N SF C C G+ L+ G+ C ++ C + C ++ + C
Sbjct: 5198 ESSP-CHQRCFNAIGSFHCGCEPGYQLK--GRKCMDVNECRQNVCRPDQHCKNTRGGYKC 5254
Query: 550 --QCFEGYILREDGKTCRRKDVCQAIDHGCEH--ICVNSDDSYTCECLEGFRLAEDGKRC 605
C G E+G TC D C+ H C + IC N+ SY C C G+R G+ C
Sbjct: 5255 IDLCPNGMTKAENG-TCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPC 5313
Query: 606 RRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
+ C+ C H C N S+ C C G L DG+ C
Sbjct: 5314 MDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSC 5354
Score = 117 bits (293), Expect = 5e-26
Identities = 92/319 (28%), Positives = 127/319 (39%), Gaps = 64/319 (20%)
Query: 237 CTAHMCSTLEHNCAHFCINIPGSYVC--RCKQGYILNSDQTTCRIQDLCAMEDHNCE--Q 292
C ++C +H C N G Y C C G + ++ TC D C H C Q
Sbjct: 5234 CRQNVCRPDQH-----CKNTRGGYKCIDLCPNG-MTKAENGTCIDIDECKDGTHQCRYNQ 5287
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFAL 352
+C N GS+ C C GY G+ C+ ++ C C H+C N GS+ C C G L
Sbjct: 5288 ICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHL 5347
Query: 353 NPDKKTCTKIDYCASSNHGCQHECVNTD----------------------DSYSCH---- 386
D K+C ++ N+G Q+ N SYS +
Sbjct: 5348 LGDGKSCAGLE--RLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSR 5405
Query: 387 -------------CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYT 433
C +G + D TC I+ C N C+HEC N SY C C GY
Sbjct: 5406 TSLSRTRRTIRKTCPEGSEASHD--TCVDIDECE-NTDACQHECKNTFGSYQCICPPGYQ 5462
Query: 434 LDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVC---QCSEGF----LINEDLKTCSR 484
L NGKTC +D C +Q+ C ++C N S+ C C + + LK C
Sbjct: 5463 LTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPP 5522
Query: 485 VDY-CLLSDHGCEYSCVNM 502
D C LS + EY V++
Sbjct: 5523 NDLECALSPYALEYKLVSL 5541
>gi|194328809 latent transforming growth factor beta binding protein 3
isoform 1 [Homo sapiens]
Length = 1303
Score = 182 bits (461), Expect = 2e-45
Identities = 130/452 (28%), Positives = 182/452 (40%), Gaps = 60/452 (13%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309
FCIN PG Y C C GY L + + C D C + C N PGSF C C GY
Sbjct: 675 FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
Query: 310 ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
++ G C V+ CA + C N GS+ C C +G+A PD ++C +D C + +
Sbjct: 735 R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
Query: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
C NT S+ C CL G+ L+ D+ C I+ C +C+N SY C C
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
Query: 430 RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
+G+ L G+ C +D C+Q C C N + S+VC C EGF +D C V+
Sbjct: 854 QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ 912
Query: 488 ------CLLS-----------------------------DHGCEYSC-VNMDRSFACQCP 511
C L+ DH Y C V F CP
Sbjct: 913 PHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCP 972
Query: 512 EGHVLRSDGKTC-------AKLDSCAL-GDHGC-EHSCVSSEDSFVCQCFEGYILREDGK 562
+G D +D C L G C E CV+++ + C C +G+ DG
Sbjct: 973 DGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYY--DGN 1030
Query: 563 TCRRKDVCQAIDH-GCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-----DVCKSTH 615
DV + +D C + +C N+ Y C C + ++C D C+
Sbjct: 1031 LLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPA 1090
Query: 616 HGCEHICVNNGNSYICKCSEGFVLAEDGRRCK 647
CVN SY C+C +V GR C+
Sbjct: 1091 ACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQ 1122
Score = 176 bits (446), Expect = 9e-44
Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
C ++ C H C+ P Y C C GY + C + C E + +C+N G
Sbjct: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
Query: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355
S+ C C GY L G+ CV ++ CA + H C C+N G Y C C+ G+ L
Sbjct: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
Query: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
+ C ID C + +C N S+ C + + CR +N CA P
Sbjct: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756
Query: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474
C N+ S+ C C +GY P+G++C VD C D +C NT SF CQC G+
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816
Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
++ D C +D C C+N + S+ C CP+GH L G+ C +D C+
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875
Query: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591
C +C + + S+VC C EG+ +D C + H + +N DD+ C+
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930
Score = 171 bits (434), Expect = 2e-42
Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)
Query: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379
D C + C H ECV Y C C+ G+ +P + C ++ C + G + C+NT
Sbjct: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
Query: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434
SY+CHC +G+ L+ ++C +N CA KP G C+N Y C C+ GY L
Sbjct: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693
Query: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492
+ C +D C + C N SF C C G+ ++ C V+ C
Sbjct: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752
Query: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552
C N+ SF C C +G+ DG++C +D C GD C ++ SF CQC
Sbjct: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812
Query: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612
GY L D C D C C+N++ SY C C +G RL G++C+ D C
Sbjct: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871
Query: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
C C N SY+C C EGF +D C++
Sbjct: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909
Score = 152 bits (384), Expect = 1e-36
Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)
Query: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417
T+ D C + + C H ECV YSCHC G+ +P + C +N C G C
Sbjct: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
+N SY C C+RGY L G++C ++ CA + H C C+N + C C G+
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691
Query: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532
+ C +D C + C N SF C + G C ++ CA G
Sbjct: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751
Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
C + SF C C +GY DG++C D C+A D IC N+ S+ C+C
Sbjct: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811
Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649
L G+ L+ D C D C C+N SY C C +G L GR+C+ +C
Sbjct: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870
Query: 650 TEGP 653
++ P
Sbjct: 871 SQDP 874
Score = 125 bits (314), Expect = 2e-28
Identities = 128/540 (23%), Positives = 179/540 (33%), Gaps = 145/540 (26%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
+C N+PGS+ C C QGY D +C D C D +C N PGSF CQC SGY L
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817
Query: 312 AED----------------------------------------GKRCVAVDYCASENHGC 331
+ D G++C +D C+ + C
Sbjct: 818 SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLC 877
Query: 332 --EHECVNADGSYLCQCHEGFALNPDKKTCTKID----------------YCAS---SNH 370
C N GSY+C C EGF D+ C +++ +C S +N
Sbjct: 878 LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
Query: 371 GCQHECVNTDDSYSCHCL-------------------KGFT-----LNPDKKTCRRINYC 406
Q C + + HC KG+T +N R I+ C
Sbjct: 938 TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
Query: 407 AL--NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDS 464
L ++ E +CVN + Y C C +G+ D N C VD C + + +C NT
Sbjct: 998 MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGG 1057
Query: 465 FVCQCSEGFLINEDLKTCSR-----VDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSD 519
+ C C+ + + C VD C CVN+ S+ C+C V
Sbjct: 1058 YRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPS 1117
Query: 520 GKTCAKLDSCALGDHGCEHSCVSS--EDSFVCQCFEGYILREDGKTCRR----------- 566
G+ C +S A C S ED G L D CR+
Sbjct: 1118 GRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPC 1177
Query: 567 ---------------------------------KDVCQAIDHGCEHI---CVNSDDSYTC 590
+D + C + CV C
Sbjct: 1178 PPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVC 1237
Query: 591 ECLEGFRLAEDGKRCRRKDVCKSTHHG---CE-HICVNNGNSYICKCSEGFVLAEDGRRC 646
EC GF+L RC D C+ + C+ CVN S+ C C GF + C
Sbjct: 1238 ECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1297
Score = 47.4 bits (111), Expect = 6e-05
Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)
Query: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298
H C L++ + G C QGY LNS T C+ + CAM C+N P
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374
Query: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350
GS+ C C G++L +C+A C S H C+H LC C G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434
Query: 351 ALNPDKKTC 359
A + C
Sbjct: 435 AWGARCQRC 443
Score = 45.1 bits (105), Expect = 3e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308
C+ PG VC C G+ L++ + C D C + C+ + CVN GSF C C +G
Sbjct: 1228 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1287
Query: 309 YALAEDGKRCV 319
+A + CV
Sbjct: 1288 FARSRPHGACV 1298
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)
Query: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
H C QL V G C GY + C ++ CA C H +C+N
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374
Query: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390
GSY C C G +L P + C + C S H CQH C C G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)
Query: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605
C +GY R + C+ + C A+ C H C+N+ SY C C G L +C
Sbjct: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
Query: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652
K +C S H C+H +C CS G G RC++C T+G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447
Score = 38.5 bits (88), Expect = 0.030
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)
Query: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449
C+ IN CA+ PG C H +C+N SY C C G++L P+ C S
Sbjct: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
Query: 450 QDHGCEQLCLNTEDSFVCQCSEG 472
+H C+ +C CS G
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVG 433
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)
Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375
+C + Y + G V AD C +G+ + C I+ CA C+H +
Sbjct: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369
Query: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400
C+N SY C C G +L P + C
Sbjct: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 35.4 bits (80), Expect = 0.25
Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)
Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564
CP+G+ R + C ++ CA+ C H C+++ S+ C C G+ L C
Sbjct: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
Query: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
K +C + +H C+H C C G G RC+R
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442
Score = 33.9 bits (76), Expect = 0.73
Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)
Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531
+D+ C+ C D C+N S+ C CP GH L C K + +L
Sbjct: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
Query: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572
+H C+H + +C C G + G C+R K++C A
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457
Score = 32.0 bits (71), Expect = 2.8
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)
Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
C ++ Y + KPG V + C +GY N C ++ CA CL
Sbjct: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371
Query: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511
N S+ C C G + C + + L+S +H C++ C C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431
Query: 512 EG 513
G
Sbjct: 432 VG 433
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 176 bits (446), Expect = 9e-44
Identities = 106/359 (29%), Positives = 158/359 (44%), Gaps = 15/359 (4%)
Query: 242 CSTLEHNCAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-LCVNVPG 299
C ++ C H C+ P Y C C GY + C + C E + +C+N G
Sbjct: 578 CRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG 637
Query: 300 SFVCQCYSGYAL--AEDGKRCVAVDYCASENHGCEHE--CVNADGSYLCQCHEGFALNPD 355
S+ C C GY L G+ CV ++ CA + H C C+N G Y C C+ G+ L
Sbjct: 638 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 696
Query: 356 K-KTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
+ C ID C + +C N S+ C + + CR +N CA P
Sbjct: 697 RPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSP 756
Query: 415 HECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFL 474
C N+ S+ C C +GY P+G++C VD C D +C NT SF CQC G+
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYH 816
Query: 475 INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDH 534
++ D C +D C C+N + S+ C CP+GH L G+ C +D C+
Sbjct: 817 LSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGRKCQDIDECSQDPS 875
Query: 535 GC--EHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCE 591
C +C + + S+VC C EG+ +D C + H + +N DD+ C+
Sbjct: 876 LCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQ----PHHKKECYLNFDDTVFCD 930
Score = 175 bits (444), Expect = 2e-43
Identities = 120/411 (29%), Positives = 172/411 (41%), Gaps = 26/411 (6%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQT-TCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCYSGY 309
FCIN PG Y C C GY L + + C D C + C N PGSF C C GY
Sbjct: 675 FCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGY 734
Query: 310 ALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
++ G C V+ CA + C N GS+ C C +G+A PD ++C +D C + +
Sbjct: 735 R-SQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGD 793
Query: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCH 429
C NT S+ C CL G+ L+ D+ C I+ C +C+N SY C C
Sbjct: 794 VCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCP 853
Query: 430 RGYTLDPNGKTCSRVDHCAQQDHGC--EQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDY 487
+G+ L G+ C +D C+Q C C N + S+VC C EGF +D C V+
Sbjct: 854 QGHRL-VGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVE- 911
Query: 488 CLLSDHGCEYSCVNMDRSFACQCPEGHVLRSD--GKTCAKLDSCALGDHGCEHSC-VSSE 544
H + +N D + C VL ++ + C GDH + C V S
Sbjct: 912 ---QPHHKKECYLNFDDTVFCD----SVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSS 964
Query: 545 DSFVCQCFEGYILREDGKTCR-----RKDVCQAIDHGCEHI----CVNSDDSYTCECLEG 595
F C +G +D +D+ + + G E CVN+ Y C C +G
Sbjct: 965 AEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQG 1024
Query: 596 FRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
F + C D C + +C N Y C C+ + R+C
Sbjct: 1025 FYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQC 1075
Score = 171 bits (434), Expect = 2e-42
Identities = 105/338 (31%), Positives = 150/338 (44%), Gaps = 15/338 (4%)
Query: 322 DYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG-CQHECVNT 379
D C + C H ECV Y C C+ G+ +P + C ++ C + G + C+NT
Sbjct: 576 DECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNT 635
Query: 380 DDSYSCHCLKGFTLN--PDKKTCRRINYCALNKP---GCEHECVNMEESYYCRCHRGYTL 434
SY+CHC +G+ L+ ++C +N CA KP G C+N Y C C+ GY L
Sbjct: 636 GGSYNCHCNRGYRLHVGAGGRSCVDLNECA--KPHLCGDGGFCINFPGHYKCNCYPGYRL 693
Query: 435 DPN-GKTCSRVDHCAQQDHGCEQLCLNTEDSFVC-QCSEGFLINEDLKTCSRVDYCLLSD 492
+ C +D C + C N SF C C G+ ++ C V+ C
Sbjct: 694 KASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYR-SQGGGACRDVNECAEGS 752
Query: 493 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF 552
C N+ SF C C +G+ DG++C +D C GD C ++ SF CQC
Sbjct: 753 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCL 812
Query: 553 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK 612
GY L D C D C C+N++ SY C C +G RL G++C+ D C
Sbjct: 813 SGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDECS 871
Query: 613 STHHGC--EHICVNNGNSYICKCSEGFVLAEDGRRCKK 648
C C N SY+C C EGF +D C++
Sbjct: 872 QDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEE 909
Score = 152 bits (384), Expect = 1e-36
Identities = 93/304 (30%), Positives = 133/304 (43%), Gaps = 12/304 (3%)
Query: 360 TKIDYCASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHE-C 417
T+ D C + + C H ECV YSCHC G+ +P + C +N C G C
Sbjct: 573 TETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 418 VNMEESYYCRCHRGYTL--DPNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
+N SY C C+RGY L G++C ++ CA + H C C+N + C C G+
Sbjct: 633 MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGY 691
Query: 474 LINEDL-KTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALG 532
+ C +D C + C N SF C + G C ++ CA G
Sbjct: 692 RLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEG 751
Query: 533 DHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC 592
C + SF C C +GY DG++C D C+A D IC N+ S+ C+C
Sbjct: 752 SPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQC 811
Query: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCK---KC 649
L G+ L+ D C D C C+N SY C C +G L GR+C+ +C
Sbjct: 812 LSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLV-GGRKCQDIDEC 870
Query: 650 TEGP 653
++ P
Sbjct: 871 SQDP 874
Score = 132 bits (332), Expect = 2e-30
Identities = 131/504 (25%), Positives = 177/504 (35%), Gaps = 120/504 (23%)
Query: 252 FCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYAL 311
+C N+PGS+ C C QGY D +C D C D +C N PGSF CQC SGY L
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHL 817
Query: 312 AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS--- 368
+ D C +D C +C+N +GSY C C +G L +K C ID C+
Sbjct: 818 SRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRK-CQDIDECSQDPSL 876
Query: 369 ---------------------------NHGCQH--------EC-VNTDDSYSC------- 385
HGC+ EC +N DD+ C
Sbjct: 877 CLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATN 936
Query: 386 ----------------HCL-------------------KGFT-----LNPDKKTCRRINY 405
HC KG+T +N R I+
Sbjct: 937 VTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDE 996
Query: 406 CAL--NKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTED 463
C L ++ E +CVN + Y C C +G+ D N C VD C + + +C NT
Sbjct: 997 CMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRG 1056
Query: 464 SFVCQCSEGFLINEDLKTC----------SRVDYCLLSDHGCEYSCVNMDRSFA-----C 508
+ C C+ + + C R D C S G + C A C
Sbjct: 1057 GYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCW-SQRGEDGMCAGPLAGPALTFDDC 1115
Query: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSF--VCQCFEGYILREDGKTCRR 566
C +G R G C G H C S S +SF G R++ +
Sbjct: 1116 CCRQG---RGWGAQCRPCPPRGAGSH-CPTS-QSESNSFWDTSPLLLGKPPRDEDSSEED 1170
Query: 567 KDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CE-HIC 622
D C+ + C V CEC GF+L RC D C+ + C+ C
Sbjct: 1171 SDECRCVSGRC----VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERC 1226
Query: 623 VNNGNSYICKCSEGFVLAEDGRRC 646
VN S+ C C GF + C
Sbjct: 1227 VNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 47.4 bits (111), Expect = 6e-05
Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 11/129 (8%)
Query: 240 HMCSTLEHNCAHFCINIPGSYVCRCKQGYI-LNSDQTTCRIQDLCAMEDHNCEQLCVNVP 298
H C L++ + G C QGY LNS T C+ + CAM C+N P
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS--THCQDINECAMPGVCRHGDCLNNP 374
Query: 299 GSFVCQCYSGYALAEDGKRCVA-----VDYC---ASENHGCEHECVNADGSYLCQCHEGF 350
GS+ C C G++L +C+A C S H C+H LC C G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGK 434
Query: 351 ALNPDKKTC 359
A + C
Sbjct: 435 AWGARCQRC 443
Score = 45.1 bits (105), Expect = 3e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 4/71 (5%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---CE-QLCVNVPGSFVCQCYSG 308
C+ PG VC C G+ L++ + C D C + C+ + CVN GSF C C +G
Sbjct: 1181 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG 1240
Query: 309 YALAEDGKRCV 319
+A + CV
Sbjct: 1241 FARSRPHGACV 1251
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/119 (28%), Positives = 42/119 (35%), Gaps = 18/119 (15%)
Query: 288 HNCEQLCVN-------VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEH-ECVNAD 339
H C QL V G C GY + C ++ CA C H +C+N
Sbjct: 317 HKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL-NSTHCQDINECAMPGV-CRHGDCLNNP 374
Query: 340 GSYLCQCHEGFALNPDKKTC-----TKIDYC---ASSNHGCQHECVNTDDSYSCHCLKG 390
GSY C C G +L P + C + C S H CQH C C G
Sbjct: 375 GSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG 433
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/112 (30%), Positives = 48/112 (42%), Gaps = 15/112 (13%)
Query: 551 CFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRC---- 605
C +GY R + C+ + C A+ C H C+N+ SY C C G L +C
Sbjct: 341 CPQGY-KRLNSTHCQDINEC-AMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
Query: 606 -RRKDVC---KSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKC-TEG 652
K +C S H C+H +C CS G G RC++C T+G
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAW---GARCQRCPTDG 447
Score = 38.5 bits (88), Expect = 0.030
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)
Query: 400 CRRINYCALNKPG-CEH-ECVNMEESYYCRCHRGYTLDPNGKTC--------SRVDHCAQ 449
C+ IN CA+ PG C H +C+N SY C C G++L P+ C S
Sbjct: 353 CQDINECAM--PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVS 410
Query: 450 QDHGCEQLCLNTEDSFVCQCSEG 472
+H C+ +C CS G
Sbjct: 411 PEHQCQHPLTTRLTRQLCCCSVG 433
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/85 (28%), Positives = 36/85 (42%), Gaps = 9/85 (10%)
Query: 317 RCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQH-E 375
+C + Y + G V AD C +G+ + C I+ CA C+H +
Sbjct: 318 KCPQLQYTGVQKPGPVRGEVGAD------CPQGYK-RLNSTHCQDINECAMPGV-CRHGD 369
Query: 376 CVNTDDSYSCHCLKGFTLNPDKKTC 400
C+N SY C C G +L P + C
Sbjct: 370 CLNNPGSYRCVCPPGHSLGPSRTQC 394
Score = 35.4 bits (80), Expect = 0.25
Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%)
Query: 510 CPEGHVLRSDGKTCAKLDSCALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTC---- 564
CP+G+ R + C ++ CA+ C H C+++ S+ C C G+ L C
Sbjct: 341 CPQGYK-RLNSTHCQDINECAMPGV-CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK 398
Query: 565 -RRKDVCQAI---DHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRR 607
K +C + +H C+H C C G G RC+R
Sbjct: 399 PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQR 442
Score = 33.9 bits (76), Expect = 0.73
Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 26/113 (23%)
Query: 477 EDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCA--KLDSCAL--- 531
+D+ C+ C D C+N S+ C CP GH L C K + +L
Sbjct: 354 QDINECAMPGVCRHGD------CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
Query: 532 ---GDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRR---------KDVCQA 572
+H C+H + +C C G + G C+R K++C A
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVG---KAWGARCQRCPTDGTAAFKEICPA 457
Score = 32.0 bits (71), Expect = 2.8
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 15/122 (12%)
Query: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
C ++ Y + KPG V + C +GY N C ++ CA CL
Sbjct: 319 CPQLQYTGVQKPGPVRGEVGAD------CPQGYKR-LNSTHCQDINECAMPGVCRHGDCL 371
Query: 460 NTEDSFVCQCSEGFLINEDLKTC-------SRVDYCLLS-DHGCEYSCVNMDRSFACQCP 511
N S+ C C G + C + + L+S +H C++ C C
Sbjct: 372 NNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS 431
Query: 512 EG 513
G
Sbjct: 432 VG 433
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 171 bits (433), Expect = 3e-42
Identities = 95/338 (28%), Positives = 156/338 (46%), Gaps = 64/338 (18%)
Query: 293 LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHE--CVNADGSYLC------ 344
LC+ PG+ QC +G+ L +C+ +D C + C + CVN +G YLC
Sbjct: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
Query: 345 -------------------------------------QCHEGFALNPDKKTCTKIDYCAS 367
C G+ ++ + C +D CA+
Sbjct: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD-ESNQCVDVDECAT 133
Query: 368 SNHGCQ--HECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
+H C C+NT+ Y+C C G+ L + C I+ C C+ C N+ SY
Sbjct: 134 DSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYS 189
Query: 426 CRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRV 485
C C+ G+TL+ +G++C V+ CA ++ C Q C+NT SF+C+C G+ + ED CS +
Sbjct: 190 CTCNPGFTLNEDGRSCQDVNECA-TENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDM 248
Query: 486 DYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGC--EHSCVSS 543
D C S+ C++ CVN ++ C CP G++L D ++C ++ C +H C + +C +
Sbjct: 249 DECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNL 308
Query: 544 EDSFVC----QCFEGYILREDGKTCRRKDVCQAIDHGC 577
+ F C +C E Y+ D + +C A + GC
Sbjct: 309 QGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341
Score = 167 bits (424), Expect = 3e-41
Identities = 102/334 (30%), Positives = 153/334 (45%), Gaps = 25/334 (7%)
Query: 335 CVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHE--CVNTDDSYSC-----HC 387
C+ + G+ QC GF L+ C ID C + C+ + CVN + Y C
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHC 447
+G NP T Y A P + CR GY +D + + C VD C
Sbjct: 76 YRGPYSNP-YSTPYSGPYPAAAPPLSAPNYPTISRPLICRF--GYQMDESNQ-CVDVDEC 131
Query: 448 AQQDHGCE--QLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRS 505
A H C Q+C+NTE + C C++G+ + E C +D C C+ C N+ S
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEG--QCLDIDECRYGY--CQQLCANVPGS 187
Query: 506 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR 565
++C C G L DG++C ++ CA ++ C +CV++ SF+C+C GY L EDG C
Sbjct: 188 YSCTCNPGFTLNEDGRSCQDVNECAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCS 246
Query: 566 RKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICV 623
D C + C+H CVN +Y C C G+ L +D + C+ + C+ +H C + C
Sbjct: 247 DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCY 306
Query: 624 NNGNSYIC----KCSEGFVLAEDGRRCKKCTEGP 653
N + C +C E ++ D RC E P
Sbjct: 307 NLQGGFKCIDPIRCEEPYLRISD-NRCMCPAENP 339
Score = 164 bits (415), Expect = 4e-40
Identities = 96/337 (28%), Positives = 148/337 (43%), Gaps = 64/337 (18%)
Query: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNC--EQLCVNVPGSFVC------- 303
C+ PG+ +C G+ L+ C D C C + +CVN G ++C
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPV 75
Query: 304 ------------------------------------QCYSGYALAEDGKRCVAVDYCASE 327
C GY + ++ +CV VD CA++
Sbjct: 76 YRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQM-DESNQCVDVDECATD 134
Query: 328 NHGCE--HECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSC 385
+H C C+N +G Y C C +G+ L + C ID C CQ C N SYSC
Sbjct: 135 SHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRYGY--CQQLCANVPGSYSC 190
Query: 386 HCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVD 445
C GFTLN D ++C+ +N CA P C CVN S+ CRC GY L+ +G CS +D
Sbjct: 191 TCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPGYELEEDGVHCSDMD 249
Query: 446 HCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGC--EYSCVNMD 503
C+ + C+ C+N ++ C C G+++ +D ++C ++ C +H C + +C N+
Sbjct: 250 ECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQ 309
Query: 504 RSFAC----QCPEGHVLRSDGKTCAKLDSCALGDHGC 536
F C +C E ++ SD + C + GC
Sbjct: 310 GGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGC 341
Score = 153 bits (387), Expect = 6e-37
Identities = 84/221 (38%), Positives = 110/221 (49%), Gaps = 18/221 (8%)
Query: 242 CSTLEHNC--AHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPG 299
C+T H C CIN G Y C C GY L Q C D C C+QLC NVPG
Sbjct: 131 CATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQ--CLDIDECRY--GYCQQLCANVPG 186
Query: 300 SFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTC 359
S+ C C G+ L EDG+ C V+ CA+EN C CVN GS++C+C G+ L D C
Sbjct: 187 SYSCTCNPGFTLNEDGRSCQDVNECATEN-PCVQTCVNTYGSFICRCDPGYELEEDGVHC 245
Query: 360 TKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC--EHEC 417
+ +D C+ S CQHECVN +Y C C G+ L D ++C+ IN C C + C
Sbjct: 246 SDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTC 305
Query: 418 VNMEESYYC----RCHRGYTLDPNGKTCSRVDHCAQQDHGC 454
N++ + C RC Y L + C C ++ GC
Sbjct: 306 YNLQGGFKCIDPIRCEEPY-LRISDNRCM----CPAENPGC 341
Score = 135 bits (341), Expect = 1e-31
Identities = 65/174 (37%), Positives = 86/174 (49%), Gaps = 12/174 (6%)
Query: 249 CAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSG 308
C C N+PGSY C C G+ LN D +C+ + CA E+ C Q CVN GSF+C+C G
Sbjct: 177 CQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENP-CVQTCVNTYGSFICRCDPG 235
Query: 309 YALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASS 368
Y L EDG C +D C+ C+HECVN G+Y C C G+ L D ++C I+ C
Sbjct: 236 YELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHR 295
Query: 369 NHGC--QHECVNTDDSYSC----HCLKGFTLNPDKKTCRRINYCALNKPGCEHE 416
NH C Q C N + C C + + D + C PGC +
Sbjct: 296 NHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRC-----MCPAENPGCRDQ 344
Score = 97.8 bits (242), Expect = 4e-20
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
C+T E+ C C+N GS++CRC GY L D C D C+ + C+ CVN PG++
Sbjct: 211 CAT-ENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTY 269
Query: 302 VCQCYSGYALAEDGKRCVAVDYCASENHGC--EHECVNADGSYLC----QCHEGFALNPD 355
C C GY L +D + C ++ C NH C + C N G + C +C E + D
Sbjct: 270 FCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISD 329
Query: 356 KKTCTKIDYCASSNHGCQHE 375
+ C + N GC+ +
Sbjct: 330 NRC-----MCPAENPGCRDQ 344
Score = 35.4 bits (80), Expect = 0.25
Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 580 ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC 631
+C+ S + +C GF L +C D C++ C + +CVN Y+C
Sbjct: 15 LCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,871,961
Number of Sequences: 37866
Number of extensions: 1882053
Number of successful extensions: 12803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 193
Number of HSP's that attempted gapping in prelim test: 4513
Number of HSP's gapped (non-prelim): 2704
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.